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Sample records for aplasia efficacite therapeutique

  1. Therapeutic efficiency of synthokine SC-55494, a human IL-3 receptor agonist, in a nonhuman primate model of HIGH dose, sublethal, radiation-induced marrow aplasia; Efficacite therapeutique d`un variant d`interleukine-3 chez des macaques irradies

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    Herodin, F.; Farese, A.; Grab, L.; McKearn, J.P.; Mestries, J.C.; McVittie, T.J.

    1994-12-31

    The synthetic cytokine (Synthokine) SC-55494 is a high affinity IL-3 receptor ligand. The therapeutic administration of Synthokine to total body irradiated (TBI) monkeys (7 Gy gamma) from day 1 post TBI for 23 days, significantly enhanced platelet recovery and modulated aneutrophil nadir. (author). 6 refs.

  2. Radiological Findings of Michel Aplasia

    Science.gov (United States)

    Umul, Ayse; Demirtas, Hakan; Celik, Ahmet Orhan

    2016-01-01

    Introduction: Congenital abnormalities of the inner ear is the most common cause of neurosensory hearing loss. Michel inner ear deformity is a rare developmental anomaly refers to the total aplasia of the inner ear. It is caused by developmental arrest of otic placode early during the third week of gestational age. Case report: We have discussed here that three year old girl diagnosed Michel aplasia with temporal bone computed tomography (CT) and temporal magnetic resonance imaging (MRI) findings. PMID:27482139

  3. Autoimmune Lymphoproliferative Syndrome with Red Cell Aplasia.

    Science.gov (United States)

    Meena, K R; Bisht, Supriya; Tamaria, K C

    2015-12-01

    Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare inherited disorder of abnormal lymphocyte apoptosis, leading to chronic lymphoproliferation. It presents as lymphadenopathy, hepatosplenomegaly and autoimmune phenomena. Pure red cell aplasia is characterized by normochromic normocytic anemia, reticulocytopenia, and absence of erythroblasts from a normal bone marrow. Only few lymphoproliferative disorders have been associated with erythroid aplasia. The authors are reporting a case of ALPS associated with red cell aplasia in a 7-y-old girl.

  4. Condylar Aplasia and Hypoplasia: A Rare Case

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    Peeyush Shivhare

    2013-01-01

    Full Text Available Aplasia of condyle is very rare, when this condition not seen as a part of a syndrome. We report a case of condylar aplasia on the right side and hypoplasia on the left side in a 21-year-old female. The patient reported to the department with a chief complaint of underdeveloped lower jaw. Clinical examination, conventional radiographs, and 3D CBCT images revealed complete absence of condyle on the right side and hypoplasia on the left side.

  5. Diphenylhydantoin-induced pure red cell aplasia.

    Science.gov (United States)

    Rusia, Usha; Malhotra, Purnima; Joshi, Panul

    2006-01-01

    Pure red cell aplasia is an uncommon complication of diphenylhydantoin therapy. It has not been reported in Indian literature. Awareness of the entity helps in establishing the cause of anaemia in these patients and alerts the physicians to the need of comprehensive haematological monitoring in these patients. A case of 58-year-old male who developed pure red cell aplasia following three months of diphenylhydantoin therapy is reported here.

  6. Aplasia of major pectoral muscle combined with renal aplasia and cystic malformation of common iliac vein

    DEFF Research Database (Denmark)

    Qvist, N; Nielsen, K; Christensen, P V

    1987-01-01

    We report a case of an eighteen-year-old male with combined aplasia of the major pectoral muscle, renal aplasia, and malformation of the common iliac vein. The possibility of a common genesis is discussed on the basis of embryology....

  7. Nonsyndromic Facial Asymmetry with Unilateral Condylar Aplasia

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    Ranganadh Nallamothu

    2013-01-01

    Full Text Available Introduction. The temporomandibular joint (TMJ is the most complex elegantly designed joint in the human body. Abnormal development and growth of TMJ may lead to condyle aplasia present in several syndromes expressions, but it is extremely rare when not connected to any underlying pathological disorder or in conjunction with any syndrome. Objective. A rare case of aplasia of the mandibular condyle is presented, along with 3D computed tomography (3D CT findings. Conclusion. Based on clinical and radiological findings we suggest the abnormal development of the TMJ as the origin. The 3D CT has provided high-quality images, which made diagnosis and a prompt treatment plan possible.

  8. Aplasias Medulares Congénitas

    OpenAIRE

    A. Esteves; O. FREITAS; Almeida, T.; Rosado, L

    2010-01-01

    Las aplasias medulares congénitas constituyen un grupo heterogéneo de enfermedades que se caracterizan por insuficiencia medular, asociadas frecuentemente a una o más anomalías somáticas y con riesgo elevado de neoplasias.Son enfermedades raras, generalmente diagnosticadas en la edad pediátrica, y con una mortalidad prematura importante. Los autores presentan 11 casos de aplasia medular congénita,8 deanemia de Fanconiy 3 de disqueratosis congénita. Estos casos fueron diagnostic...

  9. A. Bandura. Auto-efficacité. Le sentiment d’efficacité personnelle

    OpenAIRE

    Rondier, Maïlys

    2009-01-01

    Albert Bandura est docteur en psychologie et enseigne à l’université de Stanford (Californie). Il est l’auteur de L’Apprentissage social (Mardaga, 1985). Depuis les années 80, Albert Bandura s’intéresse au sentiment d’efficacité personnelle. Ce concept s’inscrit dans le cadre de la théorie sociocognitive (théorie issue du béhaviorisme et du cognitivisme). Selon cette théorie, le fonctionnement et le développement psychologique doivent être compris en considérant trois facteurs en interaction ...

  10. Acquired pure red cell aplasia in children

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    Sujata R Dafale

    2012-01-01

    Full Text Available Acquired Pure Red Cell Aplasia (PRCA is a rare occurrence in children.This is a case of an eight year old girl child who developed acquired PRCA secondary to long term intake of sodium Valproate. This case is reported to review the causes of PRCA in children and to reconsider the use of drugs of longer duration in children and adults.

  11. Unilateral optic nerve aplasia associated with microphthalmos

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    Stanković-Babić Gordana

    2012-01-01

    Full Text Available Intraduction. Optic nerve aplasia is a rare developmental anomaly characterised by the congenital absence of the optic nerve, central retinal vessels and retinal ganglion cells that is seen most often in a unilaterally malformed eye. Case report. We reported a girl with a very rare anomaly of the eye, unilateral aplasia of the optic nerve and microphthalmia. We carried out a complete ophthalmological examination, A- and Bscan ultrasonography, magnetic resonance imaging (MRI of the orbit and brain, pediatrician, neurological examinations and karyotype determination. The examined child was a third child from the third regular pregnancy, born at term (39 GS, BM 3100 g. Family ocular history was negative. The right corneal diameter was 7.5 mm and left 10 mm. On dilated fundus examination, the right eye showed the absence of optic nerve and central retinal vessels. B-scan echography showed a small right globe (axial length 13.80 mm, normal size left globe (axial length 18.30 mm and the absence of optic nerve on the right eye. Physical and neurological findings and karyotype was normal. MRI of the orbits and brain marked asymmetry of globe size and unilateral absence of the optic nerve. The patient is under the control of a competent ophthalmologist and prosthetic. Conclusion. Further aesthetic and functional development of a young person is the primary goal in tracking this rare congenital optic nerve anomalies in the malformed eye.

  12. Pulmonary Aplasia in an Adult : A Case Report

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    Nurettin Yiyit

    2016-01-01

    Full Text Available Pulmonary aplasia is a rare congenital anomaly in which there are absence of pulmonary vessels, bronchus and parenchyma. It is distinguished from pulmonary agenesis by the presence of rudimentary stump bronchus. Patients are usually diagnosed in childhood. Patients without additional anomaly and the patients with mild disease can be diagnosed in adulthood. The left lung was not observed at the chest X-ray of 19-year-old male patient with respiratory distress in exercise. Left lung aplasia was diagnosed by computed tomography and ventilation perfusion scintigraphy. The patients with lung aplasia have an increased risk of infections. Therefore the follow-up of the patients is important.

  13. Oral complications associated with idiopathic medullary aplasia: case report.

    Science.gov (United States)

    Clercq, Marcel; Gagné-Tremblay, Mélanie

    2008-05-01

    This article describes a patient who experienced serious oral sequelae after severe oral hemorrhage associated with medullary aplasia. These complications required medical, surgical and prosthetic treatments necessitating dental expertise in the hospital setting.

  14. Aplasia Cutis Congenita Association with Fetus Papyraceus

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    Ahmet Özdemir

    2015-08-01

    Full Text Available Aplasia cutis congenita (ACC is a rare malformation characterized by localized or a wide area absence of tissue. The disease may involve any site of the body, although usually seen on the scalp. Observed one in 10.000 births, it can occur as the ACC as an isolated lesion and may be associated with cleft palate/lip, syndactyly, absence of fingers, eye abnormalities and congenital heart disease. ACC’s a rare form due to intrauterine twin, which is a form of ex. Large lesions that require surgical repair small defects heal spontaneously with re-epithelialization. We present a rare case of newborn male with truncal ACC associated with fetus papyraceus.

  15. Pure White Cell Aplasia and Necrotizing Myositis

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    Peter Geon Kim

    2016-01-01

    Full Text Available Pure white cell aplasia (PWCA is a rare hematologic disorder characterized by the absence of neutrophil lineages in the bone marrow with intact megakaryopoiesis and erythropoiesis. PWCA has been associated with autoimmune, drug-induced, and viral exposures. Here, we report a case of a 74-year-old female who presented with severe proximal weakness without pain and was found to have PWCA with nonspecific inflammatory necrotizing myositis and acute liver injury on biopsies. These findings were associated with a recent course of azithromycin and her daily use of a statin. Myositis improved on prednisone but PWCA persisted. With intravenous immunoglobulin and granulocyte-colony stimulating factor therapies, her symptoms and neutrophil counts improved and were sustained for months.

  16. Acquired pure megakaryocytic aplasia successfully treated with cyclosporine

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    Halima El Omri

    2010-12-01

    Full Text Available Acquired pure megakaryocytic aplasia is a rare hematological disorder characterized by thrombocytopenia with absent or markedly reduced megakaryocytes in the bone marrow. We report a case of a 25-year-old male diagnosed as acquired pure megakaryocytic aplasia. Treatment with prednisone and intravenous immunoglobulin failed, but he was successfully treated with cyclosporine, with complete remission after 90 days and normal platelet count maintained thereafter.

  17. MANAGEMENT DE L’EFFICACITE ENERGETIQUE DANS LE BATIMENT

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    DJERROUFI, Mohammed El Amin

    2014-01-01

    Le travail présenté ci-après porte sur le management de l’efficacité énergétique dans les projets de construction et de réhabilitation des bâtiments, en adoptent une démarche managériale et environnementale qui nous permettra de réduire les consommations énergétique et limité l’impact environnemental. Pour cela à on a commencé par définir les concepts énergétique et environnemental, en s’intéressant de près à l’efficacité énergétique dans les bâtiments, afin d’assurer à l’usager un confort du...

  18. From labyrinthine aplasia to otocyst deformity

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    Giesemann, Anja Maria; Goetz, Friedrich; Lanfermann, Heinrich [Hannover Medical School, Department of Diagnostic and Interventional Neuroradiology, Hannover (Germany); Neuburger, Juergen; Lenarz, Thomas [Hannover Medical School, Department of Otorhinolaryngology, Hannover (Germany)

    2010-02-15

    Inner ear malformations (IEMs) are rare and it is unusual to encounter the rarest of them, namely labyrinthine aplasia (LA) and otocyst deformity. They do, however, provide useful pointers as to the early embryonic development of the ear. LA is characterised as a complete absence of inner ear structures. While some common findings do emerge, a clear definition of the otocyst deformity does not exist. It is often confused with the common cavity first described by Edward Cock. Our purpose was to radiologically characterise LA and otocyst deformity. Retrospective analysis of CT and MRI data from four patients with LA or otocyst deformity. Middle and inner ear findings were categorised by two neuroradiologists. The bony carotid canal was found to be absent in all patients. Posterior located cystic structures were found in association with LA and otocyst deformity. In the most severe cases, only soft tissue was present at the medial border of the middle ear cavity. The individuals with otocyst deformity also had hypoplasia of the petrous apex bone. These cases demonstrate gradual changes in the two most severe IEMs. Clarification of terms was necessary and, based on these findings, we propose defining otocyst deformity as a cystic structure in place of the inner ear, with the cochlea, IAC and carotid canal absent. This condition needs to be differentiated from the common cavity described by Edward Cook. A clear definition of inner ear malformations is essential if outcomes following cochlear implantation are to be compared. (orig.)

  19. Pulmonary Aplasia with Unusual Associations in a Woman

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    Arshad Altaf Bachh

    2014-03-01

    Full Text Available Failure of development of the primitive lung bud leads to an extremely rare congenital anomaly with a prevalence of 34 per 10 lac live births termed pulmonary aplasia. In half of such cases, associated congenital malformations of the cardiovascular, skeletal, gastrointestinal, or genitourinary systems are present. The Mayer-Rokitansky-Küster-Hauser (MRKH syndrome is defined as the congenital aplasia of the uterus and the upper two thirds of the vagina with normal secondary sexual characteristics, ovaries, and a normal karyotype (46, XX. We report an extremely rare association of right lung aplasia, MRKH syndrome, and right renal agenesis with left pelvic kidney, which to the best of our knowledge is the first such association reported.

  20. Aplasia of the parotid glands with accessory parotid tissue

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    Higley, Meghan J.; Walkiewicz, Thomas W.; Miller, Jeffrey H.; Curran, John G.; Towbin, Richard B. [Phoenix Children' s Hospital, Department of Radiology, Phoenix, AZ (United States)

    2010-03-15

    Congenital absence of the parotid gland is a rare entity. Absence is most commonly unilateral, and is not associated with accessory glandular tissue. In the majority of reported cases, parotid gland aplasia is seen with craniofacial abnormalities or hypoplasia of other ectodermal structures, particularly the lacrimal glands. We present a 14-year-old male with bilateral parotid gland aplasia detected incidentally on MRI of the brain and then confirmed on neck CT. The studies also revealed accessory parotid tissue superficial to the left masseter muscle. There were no associated craniofacial abnormalities. The lacrimal glands and submandibular glands were normal. (orig.)

  1. Non-syndromic bilateral condylar aplasia: A rare case

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    Peeyush Shivhare

    2015-01-01

    Full Text Available The temporomandibular joint is one of the most complex joints of the human body. It consists of the mandibular condyle, glenoid fossa and the articular eminence of the temporal bone. Aplasia of the condyle is usually seen as part of a syndrome otherwise it is rare. We report a case of bilateral condylar aplasia in a 20-year-old male not associated with any syndrome. The patient reported to the department with a chief complaint of the underdeveloped lower jaw. Clinical examination, conventional radiographs, and 3D computer tomography images revealed a complete absence of condyle on the right and left sides.

  2. Aplasia and hypoplasia of the maxillary sinus: A case series

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    Nasim Jafari-Pozve

    2014-01-01

    Full Text Available Maxillary sinus aplasia and hypoplasia are rare conditions that can cause symptoms such as headaches and voice alteration. The majority of patients are asymptomatic, but these conditions must be noticed for importance of differential diagnosis such as infection and neoplasms. Conventional radiographs could not differentiate between inflammatory mucosal thickening, neoplasm, and hypoplasia of the sinus. Computed tomography (CT and also cone beam computed tomography (CBCT are the proper modalities to detect these conditions. In the present study, CBCT findings of three cases with maxillary sinus hypoplasia and aplasia are reported.

  3. [Unilateral pulmonary agenesis, aplasia and dysplasia].

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    Dembinski, J; Kroll, M; Lewin, M; Winkler, P

    2009-04-01

    Unilateral pulmonary anomalies are rare events of unknown etiology and large clinical variability. Neonatal history does not allow for a reliable prognosis. Interdisciplinary mangament includes prenatal diagnostics and obstetrics, genetics, neonatology, pediatric cardiology and surgery as well as pediatric orthopedics. Neonatal history and long-term follow-up in three patients are presented here including a discussion of prenatal diagnostics and the embryo-genetic basics of lung development. In three term neonates the diagnoses of unilateral pulmonary agenesis, aplasia and dysplasia, respectively, were based on angiography, MRI and bronchoscopy. Neonatal presentation and long-term consequences were studied in the context of the current literature. Neonatal complications ranged from mild repiratory distress to pulmonary failure requiring mechanical ventilation. One patient developed scoliosis on long-term follow-up. Cardiac failure or pulmonary hypertension did not occur during follow-up, in one case lung malformation was accompanied by VACTER-association. Unilateral lung malformation is frequently associated with other, singular or complex anomalies (e.g., renal and vascular). A possible relationship to disrupted regulation of embryo-genetic factors such as T-BOX genes, PITX2 and growth factors ( FGF10), which regulate ASYMMETRICAL pulmonary morphogenesis is discussed. Disruptive unilateral pulmonary malformations may serve as a model for embryological lung development and other anomalies (e.g., congenital diaphragmatic hernia, unilateral hypoplasia and CCAM). Prenatal diagnosis is characterized by unilateral hyperechogenicity of the affected lung. Neonatal presentation is determined by mediastinal shift which may be corrected by tissue-expander implantation. Associated anomalies require cytogenetic analysis and sequencing of currently known mutations. Long-term follow-up by echocardiography and pulmonary function testing is mandatory in these patients.

  4. Pure Red Cell Aplasia Following Interleukin-2 Therapy

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    Janice P. Dutcher MD

    2016-04-01

    Full Text Available A 61-year-old woman with metastatic renal cell carcinoma underwent systemic treatment with high-dose interleukin-2 (IL-2. Anemia requiring transfusion of 1 unit of packed red blood cells (PRBCs was required during the second week of IL-2 therapy. One month following completion of high-dose IL-2 treatment, she was hospitalized for severe, symptomatic anemia and received 5 units of PRBCs. She was referred back for evaluation. A complete hematologic evaluation was performed including antiviral serology, evaluation for hemolysis, complete iron studies, and finally bone marrow aspiration and biopsy. The diagnosis was pure red cell aplasia, and no inciting viral cause could be ascertained. She required PRBCs for 5 months following IL-2 therapy. It was concluded that IL-2 was the cause of her red cell aplasia. This subsequently resolved spontaneously, and she had normal hemoglobin and hematocrit, respectively, 1 and 2 years after treatment.

  5. Primary cutaneous aspergillosis and idiopathic bone marrow aplasia*

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    Furlan, Karina Colossi; Pires, Mario Cezar; Kakizaki, Priscila; Chartuni, Juliana Cabral Nunes; Valente, Neusa Yuriko Sakai

    2016-01-01

    We describe the case of a 9-year-old boy with idiopathic bone marrow aplasia and severe neutropenia, who developed skin ulcers under cardiac monitoring electrodes. The diagnosis of primary cutaneous aspergillosis was made after the second biopsy and culture. Imaging investigation did not reveal internal fungal infection. The child was treated, but did not improve and died 3 months after admission. The report highlights and discusses the preventable risk of aspergillus skin infection in immunocompromised patients. PMID:27438213

  6. Pure Red Cell Aplasia with Adult Onset Still's Disease

    OpenAIRE

    Nicholas Robillard; Paul Nguyen; Robert Wistaff; Mikhael Laskine

    2013-01-01

    Adult Onset Still’s Disease (AOSD) is a rare inflammatory syndrome mostly seen in young adults. Known for its wide range of clinical manifestations, AOSD often presents with nonremitting systemic signs and symptoms. Many rare case associations have been described with AOSD, but only few with pure red cell aplasia (PRCA). We are presenting a fourth known case of a young female adult with AOSD and PRCA in the literature.

  7. CT and MR Imagings of Semicircular Canal Aplasia

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    Shin, Chung Hee; Hong, Hyun Sook; Yi, Beom Ha; Cha, Jang Gyu; Park, Seong Jin; Kim, Dae Ho; Lee, Hae Kyung; Kim, Shi Chan [Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of)

    2009-07-15

    To evaluate the clinical, CT and MR imaging findings of semicircular canal (SCC) aplasia and to evaluate if a correlation exists between these findings and the associated anomalies or syndromes. This study retrospectively reviewed the CT and MRI findings of five patients with SCC aplasia. The CT and MR findings were analyzed for SCC, direction of facial nerve canal, cochlea, vestibule, oval or round window, middle ear ossicles, and internal auditory canal (IAC). The subjects included three boys and two girls ranging in age from one to 120 months (mean age; 51 months). Four of the subjects had the CHARGE syndrome, and one had the Goldenhar syndrome. Moreover, four subjects had sensorineural hearing loss and one had combined hearing loss. The course of the facial nerve canal was abnormal in all five cases. Moreover, trapped cochlea and dysplastic modiolus were each observed in one case. Four subjects had atresia of the oval window; whereas ankylosis of the ossicles was present in three subjects. IAC stenosis was present in one patient with the CHARGE syndrome. The aberrant course of the facial nerve canal, atresia of the oval window, and abnormal ossicles were frequently associated in patients with SCC aplasia. In addition, the Goldenhar and CHARGE syndromes were also commonly associated syndromes.

  8. Conférence sur l'efficacité

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    Jullien, François

    2005-01-01

    Philosophe et sinologue, François Jullien présente ici une conférence qu'il a prononcée auprès de chefs d'entreprise et dans le milieu du management. D'un côté, la conception européenne de l'efficacité est liée à la modélisation comme à la finalité et revendique l'action jusqu'à l'héroïsme ; de l'autre, la pensée chinoise de l'efficience, indirecte et discrète, s'appuie sur le potentiel de situation et induit des " transformations silencieuses ", sans éclat ni même événement. Par-delà cet écart, il s'agira d'interroger la nature de l'effectivité ; ou comment l'intervention humaine réussit à se brancher sur la propension des choses et s'y laisse intégrer. Ce propos se garde donc de séparer tant soit peu l'art d'opérer sur des situations et l'exercice de la philosophie ; en résultent des effets de lecture portant sur l'histoire du XXe siècle ainsi que la géopolitique - et géoéthique - à venir.

  9. The newly recognised limb/pelvis-hypoplasia/aplasia syndrome: report of a Bedouin patient and review.

    Science.gov (United States)

    Farag, T I; al-Awadi, S A; Marafie, M J; Bastaki, L; al-Othman, S A; Mohammed, F M; AlSuliman, I S; Murthy, D S

    1993-01-01

    A Bedouin infant born to consanguineous parents and grandparents is reported. She had Müllerian aplasia and the phenotypic features of the limb/pelvis-hypoplasia/aplasia syndrome (MIM 276820). Phenotypic variability of this newly recognised syndrome is briefly discussed.

  10. Electroconvulsive Therapy and Corpus Callosum Aplasia: A 3-Year Followup

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    Ulrich Palm

    2011-01-01

    Full Text Available Electroconvulsive Therapy (ECT is a powerful treatment option in severe or chronic catatonic states and has been reported to be useful in oligophrenic patients. We report the followup medical history of a patient with corpus callosum aplasia (or agenesis who was continuously treated with ECT over three years. First, he improved considerably after a series of ECT, but relapses of catatonia made a continuous, weekly ECT necessary. Due to the severity of the brain malformation, an add-on medication with benzodiazepines and second generation antipsychotics was necessary to treat catatonic symptoms. This case emphasises the benefits of long-term ECT in oligophrenic patients.

  11. Aplasia Cutis Congenita of the Scalp with a Familial Pattern

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    Waleed AlShehri

    2016-01-01

    Full Text Available Aplasia Cutis Congenita (ACC is a condition characterized by congenital absence of skin, usually on the scalp. ACC can occur as an isolated condition or in the presence of other congenital anomalies. Here we describe a case of a 16-day-old baby girl with an isolated ACC of the scalp. Her elder two siblings have been diagnosed with ACC with concomitant cardiac or limb anomalies. The patient was managed conservatively until the defect has formed scar tissue 6 months later.

  12. THE PURE RED BLOOD CELL APLASIA IN RENAL TRANSPLANT RECIPIENT

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    B. T. Dzumabaeva

    2011-01-01

    Full Text Available The pure red blood cell aplasia of renal transplant recipients caused by parvovirus B19 (PB19 is characterized by persistent anemia which resistant to erythropoietin therapy, lack of reticulocytes, bone marrow hypoplasia, and clinically accompanied by severe recurrent bacterial, fungal and viral infection. In case of reactivation PB19 it is necessarv, first of all, eliminate the causes activation of this virus and to cancel or reduce the dose of drugs which depressed the normal hematopoiesis germs, thus to reduce the pancytopenia associating complications in this population. 

  13. A case of congenital aplasia of the epiglottis in an adult.

    Science.gov (United States)

    Kim, Yang Jae; Myung, Nam Suk; Lee, Hyoung Ju; Koo, Soo Kweon

    2014-01-01

    Aplasia or hypoplasia of the epiglottis in an adult is rarely reported congenital anomaly of the larynx. Most patients with epiglottic aplasia have presented fatal symptom of respiratory distress and severe aspiration in infancy or childhood. We present a case of congenital absence of the epiglottis found in a 33-year-old woman complaining of recurrent lingual tonsillitis. Laryngoscopic finding and CT scan revealed an isolated epiglottic aplasia and normal appearance of other laryngeal structure. This is the first description of physiologic evaluation in an epiglottic anomaly to find the compensatory mechanism of aspiration prevention. We discussed this case with a review of literature.

  14. Recurrent thymoma with stiff-person syndrome and pure red blood cell aplasia.

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    Kobayashi, Rei; Kaji, Masahiro; Horiuchi, Sho; Miyahara, Naofumi; Hino, Yumi; Suemasu, Keiichi

    2014-05-01

    Stiff-person syndrome (formerly known as stiff-man syndrome) is a very rare autoimmune and neurogenic disorder, thought to present as a paraneoplastic variant in association with thymoma. Pure red blood cell aplasia is also a paraneoplastic disorder associated with thymoma. Although separate cases of stiff-person syndrome and pure red blood cell aplasia have been reported, we describe here what is to our knowledge the first case of recurrent thymoma with both stiff-person syndrome and pure red blood cell aplasia. We describe the successful treatment of the neurogenic symptoms of stiff-person syndrome and the progressive anemia associated with pure red blood cell aplasia by tumor excision.

  15. Lack of Erythropoietic Inhibitory Effect of Serum From Patients with Congenital Pure Red Cell Aplasia

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    Geller, Gary; And Others

    1975-01-01

    Serum of five children ages 1 to 19 months with congenital pure red cell aplasia (incomplete or defective development of red blood cells) was injected in normal mice to determine possible inhibition of red blood cell formulating stimulants. (CL)

  16. Pediatric red cell disorders and pure red cell aplasia.

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    Perkins, Sherrie L

    2004-12-01

    Anemia in children may arise from a wide variety of pathogenetic mechanisms that include congenital and acquired disorders. Often the diagnostic considerations include disorders that are not seen commonly in adults and lifelong disorders that arise in children and persist throughout life. Consideration of diverse causes of anemia such as red cell membrane disorders, red cell enzymopathies, congenital dyserythropoietic anemias, congenital sideroblastic anemias, and hereditary pure red cell aplasia (Diamond-Blackfan anemia), as well as infectious causes such as parvovirus B19 infection, often is required when diagnosing anemia in an infant or young child. Knowledge of these entities that are important causes of anemia in the pediatric population, including clinical manifestations and laboratory workup, will aid in recognition of the specific disease entities and effective workup of pediatric red cell disorders.

  17. Pure red cell aplasia following autoimmune hemolytic anemia: An enigma

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    M Saha

    2013-01-01

    Full Text Available A 26-year-old previously healthy female presented with a 6-month history of anemia. The laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. With a diagnosis of autoimmune hemolytic anemia (AIHA, prednisolone was started but was ineffective after 1 month of therapy. A bone marrow trephine biopsy revealed pure red cell aplasia (PRCA showing severe erythroid hypoplasia. The case was considered PRCA following AIHA. This combination without clear underlying disease is rare. Human parvovirus B19 infection was not detected in the marrow aspirate during reticulocytopenia. The patient received azathioprine, and PRCA improved but significant hemolysis was once again documented with a high reticulocyte count. The short time interval between AIHA and PRCA phase suggested an increased possibility of the evolution of a single disease.

  18. Pure red cell aplasia following autoimmune hemolytic anemia: an enigma.

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    Saha, M; Ray, S; Kundu, S; Chakrabarti, P

    2013-01-01

    A 26-year-old previously healthy female presented with a 6-month history of anemia. The laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. With a diagnosis of autoimmune hemolytic anemia (AIHA), prednisolone was started but was ineffective after 1 month of therapy. A bone marrow trephine biopsy revealed pure red cell aplasia (PRCA) showing severe erythroid hypoplasia. The case was considered PRCA following AIHA. This combination without clear underlying disease is rare. Human parvovirus B19 infection was not detected in the marrow aspirate during reticulocytopenia. The patient received azathioprine, and PRCA improved but significant hemolysis was once again documented with a high reticulocyte count. The short time interval between AIHA and PRCA phase suggested an increased possibility of the evolution of a single disease.

  19. Medullary aplasia secondary to an irradiation accident: Treatment options and evolution of the concepts; L'aplasie medullaire secondaire a un accident d'irradiation : options therapeutiques et evolution des concepts

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, T. [Service d' Hematologie, HIA Percy, et Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Fagot, T.; Souleau, B. [Service d' Hematologie, HIA Percy, Clamart (France); Dormont, D. [Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Nedellec, G. [Service d' Hematologie, HIA Percy, Clamart (France)

    2002-07-01

    Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods. (author)

  20. Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast

    Directory of Open Access Journals (Sweden)

    Francesca Labbadia

    2012-09-01

    Full Text Available A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

  1. High incidence of recurrent copy number variants in patients with isolated and syndromic Mullerian aplasia

    OpenAIRE

    2011-01-01

    Abstract Background: Congenital malformations involving the Mullerian ducts are observed in around 5% of infertile women. Complete aplasia of the uterus, cervix, and upper vagina, also termed Mullerian aplasia or Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome occurs with an incidence of around 1 in 4,500 female births, and occurs in both isolated and syndromic forms. Previous reports have suggested that a proportion of cases, especially syndromic cases, are caused by variation in c...

  2. Pure red cell aplasia and lymphoproliferative disorders: an infrequent association.

    Science.gov (United States)

    Vlachaki, Efthymia; Diamantidis, Michael D; Klonizakis, Philippos; Haralambidou-Vranitsa, Styliani; Ioannidou-Papagiannaki, Elizabeth; Klonizakis, Ioannis

    2012-01-01

    Pure red cell aplasia (PRCA) is a rare bone marrow failure syndrome defined by a progressive normocytic anaemia and reticulocytopenia without leukocytopenia and thrombocytopenia. Secondary PRCA can be associated with various haematological disorders, such as chronic lymphocytic leukaemia (CLL) or non-Hodgkin lymphoma (NHL). The aim of the present review is to investigate the infrequent association between PRCA and lymphoproliferative disorders. PRCA might precede the appearance of lymphoma, may present simultaneously with the lymphoid neoplastic disease, or might appear following the lymphomatic disorder. Possible pathophysiological molecular mechanisms to explain the rare association between PRCA and lymphoproliferative disorders are reported. Most cases of PRCA are presumed to be autoimmune mediated by antibodies against either erythroblasts or erythropoietin, by T-cells secreting factors selectively inhibiting erythroid colonies in the bone marrow or by NK cells directly lysing erythroblasts. Finally, focus is given to the therapeutical approach, as several treatment regimens have failed for PRCA. Immunosuppressive therapy and/or chemotherapy are effective for improving anaemia in the majority of patients with lymphoma-associated PRCA. Further investigation is required to define the pathophysiology of PRCA at a molecular level and to provide convincing evidence why it might appear as a rare complication of lymphoproliferative disorders.

  3. A Patient with Unilateral Tibial Aplasia and Accessory Scrotum: A Pure Coincidence or Nonfortuitous Association?

    Directory of Open Access Journals (Sweden)

    Zoran Gucev

    2010-01-01

    Full Text Available Tibial aplasia is an uncommon lower limb malformation that can occur isolated or be part of a more complex malformation pattern. We describe a 9-year-old boy born after uneventful pregnancy and delivery. Family history was negative for maternal diabetes and other malformations. The patient presented with left tibial aplasia and homolateral prexial foot polydactyly. He also displayed enamel dysplasia and bifid scotum with cryptorchidism. Literature review failed to identify a significant syndromic association between lower limb defects of the tibial type and the genital anomalies reported here. The combination of tibial aplasia with midline genital malformations further supports the hypothesis that the tibial ray development mirrors the morphogenetic process of the radial structures. Accordingly, the malformation pattern observed in the present patient may be pathogenetically explained by an insult occurring during late blastogenesis.

  4. Anti-Erythropoietin Antibody Associated Pure Red Cell Aplasia Resolved after Liver Transplantation

    Directory of Open Access Journals (Sweden)

    Annie K. Hung

    2015-01-01

    Full Text Available Patients undergoing antiviral therapy for chronic hepatitis C often develop anemia secondary to ribavirin and interferon. Recombinant erythropoietin has been used to improve anemia associated with antiviral therapy and to minimize dose reductions, which are associated with decreased rates of sustained virologic response. A rare potential side effect of recombinant erythropoietin is anti-erythropoietin antibody associated pure red cell aplasia. In chronic kidney disease patients with this entity, there have been good outcomes associated with renal transplant and subsequent immunosuppression. In this case, a chronic liver disease patient developed anti-erythropoietin associated pure red cell aplasia and recovered after liver transplantation and immunosuppression. It is unclear whether it is the transplanted organ, the subsequent immunosuppression, or the combination that contributed to the response. In conclusion, anti-erythropoietin associated pure red cell aplasia is a serious complication of erythropoietin therapy, but this entity should not be considered a contraindication for solid organ transplantation.

  5. Treatment of pure red-cell aplasia with cyclosporine in a renal transplant patient.

    Science.gov (United States)

    Yildirim, Rahsan; Bilen, Yusuf; Keles, Mustafa; Uyanik, Abdullah; Gokbulut, Puren; Aydinli, Bulent

    2013-02-01

    Acquired pure red-cell aplasia is a rare disorder that can be either idiopathic or associated with certain autoimmune diseases, pregnancy, lymphoproliferative disorders, nutritional deficiencies, or medicines. We present a deceased-donor renal transplant patient who developed pure red-cell aplasia associated with mycophenolate mofetil or tacrolimus and was treated with cyclosporine. A 20-year-old woman was transplanted from a deceased donor 1 month earlier and presented to us with symptoms of fatigue, prostration, and palpitation. The results of a laboratory examination revealed anemia. A diagnostic work-up resulted in a diagnosis of pure red-cell aplasia. Mycophenolate mofetil was discontinued. Tacrolimus also was replaced with cyclosporine 2 months after mycophenolate mofetil was halted because of a lack of improvement in anemia. Three months later, her anemia improved with cyclosporine. Starting cyclosporine instead of tacrolimus or mycophenolate mofetil showed good improvement in our patient within 6 months of therapy.

  6. Congenital aplasia of the optic chiasm and esophageal atresia: a case report

    Directory of Open Access Journals (Sweden)

    Madonia Maurizio

    2011-08-01

    Full Text Available Abstract Introduction The complete absence of the chiasm (chiasmal aplasia is a rare clinical condition. Hypoplasia of the optic nerve and congenital nystagmus are almost invariably associated characteristics. Microphthalmos or anophthalmos are common features in chiasmal aplasia, while central nervous system abnormalities are less frequent. Esophageal atresia can be isolated or syndromic. In syndromic cases, it is frequently associated with cardiac, limb, renal or vertebral malformations and anal atresia. More rarely, esophageal atresia can be part of anophthalmia-esophageal-genital syndrome, which comprises anophthalmia or microphthalmia, genital abnormalities, vertebral defects and cerebral malformations. Here, a previously unreported case of chiasmal aplasia presenting without microphthalmos and associated with esophageal atresia is described. Case presentation Aplasia of the optic chiasm was identified in a Caucasian Italian 8-month-old boy with esophageal atresia. An ultrasound examination carried out at 21 weeks' gestation revealed polyhydramnios. Intrauterine growth retardation, esophageal atresia and a small atrial-septal defect were subsequently detected at 28 weeks' gestation. Repair of the esophageal atresia was carried out shortly after birth. A jejunostomy was carried out at four months to facilitate enteral feeding. The child was subsequently noted to be visually inattentive and to be neurodevelopmentally delayed. Magnetic resonance imaging revealed chiasmal aplasia. No other midline brain defects were found. His karyotype was normal. Conclusion If achiasmia is a spectrum, our patient seems to depict the most severe form, since he appears to have an extremely severe visual impairment. This is in contrast to most of the cases described in the literature, where patients maintain good--or at least useful-- visual function. To the best of our knowledge, the association of optic nerve hypoplasia, complete chiasmal aplasia, esophageal

  7. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.ABO incompatibility in allogeneic bone marrow transplantation may be associated with incomplete or delayed erythroid engraftment, being pure red cell aplasia (PRCA the most severe complication in this setting. Attempts for the treatment of PRCA have been made with erythropoietin or with plasmapheresis with relative success, and some authors have reported the reversibility of PRCA with antilymphocyte globulin (ALG or ATG, based on the assumption that PRCA might be immunologically mediated. We report herewith a patient with acute leukemia who developed post - BMT pure red cell aplasia. His sibling donor (sister was HLA identical and ABO incompatible, having low agglutinin

  8. Galactose-1-phosphate uridyl transferase deficiency is not associated with Mullerian aplasia in Dutch patients.

    NARCIS (Netherlands)

    Nijland, R.; Hartog, F.E.; Wevers, R.A.; Wanders, R.J.; Willemsen, W.N.P.

    2009-01-01

    STUDY OBJECTIVE: To study whether a deficiency in galactose-1-phosphate uridyl transferase (GALT) activity of mothers was an explanation for the occurrence of Mullerian aplasia of their daughters. DESIGN: A case control study. SETTING: The patients were selected from the outpatient clinic of the Uni

  9. [Bilateral deep venous thrombosis and vena cava aplasia treated with local thrombolysis

    DEFF Research Database (Denmark)

    Pelta, A.M.; Jørgensen, Maja; Just, Sven Richardt Lundgren;

    2008-01-01

    In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete...

  10. Reconstruction of bilateral tibial aplasia and split hand-foot syndrome in a father and daughter

    Directory of Open Access Journals (Sweden)

    Ali Al Kaissi

    2014-01-01

    Full Text Available Background: Tibial aplasia is of heterogeneous aetiology, the majority of reports are sporadic. We describe the reconstruction procedures in two subjects - a daughter and father manifested autosomal dominant (AD inheritance of the bilateral tibial aplasia and split hand-foot syndrome. Materials and Methods: Reconstruction of these patients required multiple surgical procedures and orthoprosthesis was mandatory. The main goal of treatment was to achieve walking. Stabilization of the ankle joint by fibular-talar-chondrodesis on both sides, followed by bilateral Brown-procedure at the knee joint level has been applied accordingly. Results: The outcome was with improved function of the deformed limbs and walking was achieved with simultaneous designation of orthotic fitting. Conclusion: This is the first study encompassing the diagnosis and management of a father and daughter with bilateral tibial aplasia associated with variable split hand/foot deformity without foot ablation. Our patients showed the typical AD pattern of inheritance of split-hand/foot and tibial aplasia.

  11. RETREATMENT WITH FLUDARABINE AND CYCLOSPORINE FOR ONE CASE OF REFRACTORY PURE RED CELL APLASIA

    Institute of Scientific and Technical Information of China (English)

    Guang-sheng He; Xiang Zhang; De-pei Wu; Ai-ning Sun; Miao Miao; Xiu-li Wang; Zheng-ming Jin

    2008-01-01

    @@ MANY cases of pure red cell aplasia (PRCA) were mediated by over-function of immune cells, and responded well to immunosuppres-sive therapy.1 Sometimes refractory cases also arose. Fludara-bine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia (CLL) and other hematological malignancies.

  12. Les secrets de l'efficacité en faire plus... en moins de temps

    CERN Document Server

    Savoyat, Bruno

    2006-01-01

    Comment gagner en efficacité grâce à une meilleure organisation et à une utilisation plus performante de l'informatique. Ce livre, rédigé par un spécialiste internationalement reconnu des méthodes d'optimisation du travail, vous fournit £ une méthode de hiérarchisation des tâches et 0 les règles qui vous permettront d'acquérir une meilleure organisation personnelle et collective. Il montre également % comment utiliser au mieux les outils informatiques (Internet, Intranet, groupware) pour parvenir à gagner en efficacité au bureau. Parce que les techniques qu'il propose ont été appliquées avec succès par plus d'1 million de personnes dans le monde, ce livre vous aidera vraiment. Grâce à ce livre vous apprendrez à : ° Mieux gérer votre emploi du temps en fonction de vos priorités, de vos responsabilités et de vos objectifs en établissant votre «carte de responsabilités» et en apprenant à déléguer. ° Mieux organiser le rangement des documents sur votre bureau, dans votre messag...

  13. Anterior Pituitary Aplasia in an Infant with Ring Chromosome 18p Deletion

    Directory of Open Access Journals (Sweden)

    Edward J. Bellfield

    2016-01-01

    Full Text Available We present the first reported case of an infant with 18p deletion syndrome with anterior pituitary aplasia secondary to a ring chromosome. Endocrine workup soon after birth was reassuring; however, repeat testing months later confirmed central hypopituitarism. While MRI reading initially indicated no midline defects, subsequent review of the images confirmed anterior pituitary aplasia with ectopic posterior pituitary. This case demonstrates how deletion of genetic material, even if resulting in a chromosomal ring, still results in a severe syndromic phenotype. Furthermore, it demonstrates the necessity of close follow-up in the first year of life for children with 18p deletion syndrome and emphasizes the need to verify radiology impressions if there is any doubt as to the radiologic findings.

  14. Bilateral posterior semicircular canal aplasia and atypical paroxysmal positional vertigo: a case report

    OpenAIRE

    Walther, LE; Nath, V.; Krombach, GA; Di Martino, E

    2008-01-01

    Isolated congenital malformations of semicircular canals are rare abnormalities. Most inner ear abnormalities occur in syndromes and are associated with hearing loss. Unilateral or bilateral single aplasia of one semicircular canal does not usually result in vertigo, but these become clinically important if there are clinical complaints of vertigo. Computed tomography imaging and high resolution magnetic resonance imaging may reveal inner ear abnormalities. The case is presented here of a 46-...

  15. [Acute hepatitis-associated pure red cell aplasia: a case report].

    Science.gov (United States)

    Della Loggia, Paolo; Cremonini, Laura

    2002-12-01

    After a holiday in Egypt, a 57-year-old caucasian woman developed acute hepatitis A. The illness seemed initially to have a benign course, with a decreasing trend of hepatic enzymes and an apparent recovery. Three weeks later a relapse occurred. Recurrence of symptoms and aminotransferase elevation were associated with severe anemia; a hyporegenerative anemia was diagnosed and all laboratory findings were consistent with pure red cell aplasia. The haematologic disorder was successfully treated with red cell transfusion and glucocorticoids.

  16. Aplasia cutis congenita er en sjælden og mulig overset kongenit anomali

    DEFF Research Database (Denmark)

    E Rogvi, Rasmus; Sommerlund, Mette; Vestergaard, Esben Thyssen

    2014-01-01

    Aplasia cutis congenita (ACC) is a rare congenital defect of the skin. In this study we present the diagnosis and management of the condition. In 1997-2009 a total of 65 ACC cases were registered in the Danish National Patient Registry (1:13.000 births). The mortality among these cases was 1.......6% (one case) though the death was not attributable to ACC, which is far lower than described in international studies....

  17. What Is Expected of the Facial Nerve in Michel Aplasia? Anatomic Variation

    OpenAIRE

    2010-01-01

    We sought better understanding about the facial nerve anatomy in the rare inner ear Michel anomaly to help better define this aplasia and prevent potential complications in surgery on these patients. The data from computed tomography scans and magnetic resonance images of six Michel aplastic ears (three patients) were evaluated for a facial nerve course. Facial nerve course and anatomic landmarks were noted. Based on data obtained from this group of very rare patients, three different facial ...

  18. [Risk factors for teeth aplasia and hypoplasia in cleft lip and palate children].

    Science.gov (United States)

    Korolenkova, M V; Starikova, N V; Ageeva, L V

    2016-01-01

    The aim of the study was to assess the significance of environmental risk factors for teeth aplasia and hypoplasia in cleft lip and palate children. Two hundred and forty-seven cleft lip and palate (CLP) children were enrolled in the study including 105 (42.5%) with bilateral CLP and 57.5% with unilateral CLP. The mean age was 11.2±4.9 years. Teeth condition was assessed clinically and radiologically. The impact of risk factors for teeth anomalies was analyzed by retrospective data obtained from computer database (absence of preoperative orthopedic treatment, palatal defects after primary palatoplasty and type of primary procedures). Surgical trauma by early periosteoplasty (at the age of 3-4 months), excessive scarring and tissue traction due to absence of early orthopedic treatment and palatal defect were associated with significantly higher incidence of incisors hypoplasia (both developmental enamel defects and microdentia) and aplasia of central incisors not seen in the other study subgroups. Incisors aplasia and hypoplasia in CLP patients do not always have disembryogenic origin but may depend on external environmental factors, including surgical trauma.

  19. The role of diclofenack on inducing of aplasia cutis congenita: a case report

    Science.gov (United States)

    2009-01-01

    Background Aplasia cutis congenita is a disorder where e newborn child is missing skin from certain areas. It is a rare condition with no particular race or sex more at risk. May occur by itself or be associated with other physical syndromes or disorders. A classification system exists for aplasia cutis congenital consisting of 9 groups, based on the number and location of the skin defects and the presence or absence of other malformations. Causes of aplasia congenital could be heredity, teratogenic substances, placental infarcts, intrauterine infections, ectodermal dysplasias etc. Diagnosis is made based on the clinical findings. Prognosis depends of the other organs malfunction level and lesions size. Case report Our case was an 22 months old Albanian girl, who was recommended to dermatology for a consultation by a pediatric surgeon because of the changes she had on her parietal part of the scalp with missing hair areas. The child has stenosis congenita ani and to her was installed stoma. In order to investigate other accompanied anomalies of the disease, there are made specific consults by neurologist, orthopedist, cardiologist, nephrologists and citogenetics. Conclusion It was found out a minor visual discoordination, Sy Floppy, Digiti V superductus pedis bill. Laxitas articularum generalisata. It was a great challenge for us to find out that during the first trimester of the pregnancy (unplanned pregnancy), her mother used Diclofenac. Since there is limited information regarding to teratogenic effects of diclofenac, we considered it interesting to present this case. PMID:19946521

  20. APLASIA CUTIS CONGÉNITA – UM CASO CLÍNICO

    Directory of Open Access Journals (Sweden)

    Mónica Costeira

    2016-07-01

    Comentários: A aplasia cutis congénita é uma lesão que pode ser causadora de grande ansiedade parental, pelo que é importante ao Pediatra o seu reconhecimento e devido esclarecimento. Apesar de se tratar, na maioria das vezes, de um defeito benigno, é importante o conhecimento da sua relação com outras anomalias e síndromes de forma a otimizar a sua orientação precoce e adequada. Da mesma forma, é importante o aconselhamento genético, nos casos que assim o justifiquem.

  1. Pure red cell aplasia due to azathioprine therapy for Crohn′s disease

    Directory of Open Access Journals (Sweden)

    Nagesh Kamath

    2016-01-01

    Full Text Available Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD, drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA therapy are well documented, but drug-associated pure red cell aplasia (PRCA is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn′s disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.

  2. Pure red cell aplasia due to azathioprine therapy for Crohn's disease.

    Science.gov (United States)

    Kamath, Nagesh; Pai, C Ganesh; Deltombe, Thylbert

    2016-01-01

    Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD), drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA) therapy are well documented, but drug-associated pure red cell aplasia (PRCA) is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn's disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.

  3. Prenatal ultrasonography of trisomy 18 with radial aplasia: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jee Young; Lee, Yeon Hee [Dankook University College of Medicine, Seoul (Korea, Republic of)

    2002-06-15

    Trisomy 18 (Edward syndrome) is the second most common chromosomal anomaly of the autosomal trisomy. Prenatal diagnosis of trisomy 18 is extremely important because of the complex malformations and lethal prognosis. Prenatal sonographic findings at 17 weeks of gestation showing radial aplasia with upper limb contracture, omphalocele, and suspicious esophageal atresia suggested the diagnosis and led to amniocentesis. Karyotyping revealed trisomy 18 (47 XX, +18, and characteristic autopsy findings were identified. We report a case of prenatally diagnosed trisomy 18 with a review of literatures.

  4. Bilateral posterior semicircular canal aplasia and atypical paroxysmal positional vertigo: a case report.

    Science.gov (United States)

    Walther, L E; Nath, V; Krombach, G A; Di Martino, E

    2008-04-01

    Isolated congenital malformations of semicircular canals are rare abnormalities. Most inner ear abnormalities occur in syndromes and are associated with hearing loss. Unilateral or bilateral single aplasia of one semicircular canal does not usually result in vertigo, but these become clinically important if there are clinical complaints of vertigo. Computed tomography imaging and high resolution magnetic resonance imaging may reveal inner ear abnormalities. The case is presented here of a 46-year-old male with a 10-year history of recurrent positional vertigo with strong onset when changing position to the left side. Magnetic resonance imaging of the inner ear showed a bilateral posterior semicircular canal aplasia as well as an enlarged vestibule on both sides. Dix-Hallpike positional manoeuvre revealed a positional nystagmus in the left head-hanging position of short duration and latency of a few seconds. When rising, vertigo occurred, but no nystagmus was visible. The fast phase of the nystagmus was mainly vertical down-beating with a slight torsional component to the uppermost ear. Although benign paroxysmal vertigo of the anterior canal was suspected, physical therapy was not effective using a modified liberatory manoeuvre. Brandt-Daroff therapy was effective permanently.

  5. What is expected of the facial nerve in michel aplasia? Anatomic variation.

    Science.gov (United States)

    Zarandy, Masoud Motasaddi; Kouhi, Ali; Kashany, Shervin Sharif; Rabiei, Sohrab; Hajimohamadi, Fatemeh; Rabbani-Anari, Mahtab

    2010-11-01

    We sought better understanding about the facial nerve anatomy in the rare inner ear Michel anomaly to help better define this aplasia and prevent potential complications in surgery on these patients. The data from computed tomography scans and magnetic resonance images of six Michel aplastic ears (three patients) were evaluated for a facial nerve course. Facial nerve course and anatomic landmarks were noted. Based on data obtained from this group of very rare patients, three different facial nerve anatomies were encountered. The first patient had normal-looking mastoid cells, normal middle ear ossicles, and a completely formed facial nerve canal through the middle ear. The second patient had pneumatized mastoid air cells despite an anomalous ossicular chain. This patient also had a facial nerve canal but not through the middle ear. In the third patient, although mastoid cells were present, neither ossicles nor a definite facial nerve canal could be detected. With guidance provided by the anatomy of the other parts of the ear, such as air cells and the ossicular chain, the danger zones posing a high probability of facial nerve injury can be predicted. Although all Michel aplasias may have aplastic petrous bone in common, there are some degrees of variation.

  6. Brachyphalangy, polydactyly and tibial aplasia/hypoplasia syndrome (OMIM 609945): case report and review of the literature.

    Science.gov (United States)

    Shafeghati, Yousef; Kahrizi, Kimia; Najmabadi, Hossein; Kuss, Andreas Walter; Ropers, Hans-Hilger; Tzschach, Andreas

    2010-12-01

    Brachyphalangy, polydactyly and tibial aplasia/hypoplasia syndrome (OMIM 609945) is a rare congenital disorder. Only seven patients have been reported to date, and the etiology of this syndrome is unknown. Autosomal dominant inheritance with variable expression has been suggested based on the presence of minor features in some parents and the fact that neither parental consanguinity nor pairs of affected siblings were observed. We report on the first patient with this syndrome who was born to consanguineous parents. Neither the mother nor the father, who were first cousins, had clinical features suggestive of a manifestation of brachyphalangy, polydactyly and tibial aplasia/hypoplasia syndrome. The patient had no siblings, and the family history was unremarkable. Clinical problems included brachydactyly of hands and feet, splaying of fingers and toes, preaxial polydactyly of feet, bilateral tibial aplasia, shortened radius and ulna, and characteristic facial dysmorphic signs. The detailed description of this patient adds to our knowledge of the clinical manifestations of brachyphalangy, polydactyly and tibial aplasia/hypoplasia syndrome and will eventually also contribute to the elucidation of the underlying gene defects.

  7. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.

  8. Influence de facteurs biotiques et abiotiques, induits et naturels, sur l'efficacité larvicide de Bacillus sphaericus Neide, 1904

    OpenAIRE

    Monteny, Nicole

    1990-01-01

    Après les problèmes apparus suite à l'utilisation des insecticides chimiques (résistance, pollution), l'alternative de la lutte biologique s'est imposée. #Bacillus sphaericus$ est une bactérie entomopathogène active essentiellement sur des larves du genre #Culex$. Son utilisation en milieu naturel révèle une perte d'efficacité imputable à des facteurs environnementaux. L'analyse de l'effet inactivant de diverses bandes spectrales de l'énergie solaire attribue ce rôle aux rayons U.V.A. (315 à ...

  9. PROPOSITION D'UN MODELE DE L'EFFICACITE DU CO-COMMISSARIAT AUX COMPTES DANS LES SOCIETES ANONYMES COTEES FRANÇAISES

    OpenAIRE

    Bennecib, Jeannette

    2002-01-01

    International audience; Si le commissariat aux comptes est une institution reconnue par un large public, le co-commissariat aux comptes semble ignoré. Dans un contexte de remise en cause de la crédibilité des informations financières et de l'opinion de l'auditeur, nous nous interrogeons sur l'efficacité d'un double contrôle dans les SA cotées françaises. A partir du cadre conceptuel normatif de l'efficacité du cocommissariat aux comptes, nous proposons un modèle explicatif fondé sur le princi...

  10. Limb-pelvis hypoplasia/aplasia: a discrete entity in the fibuloulnar developmental field complex.

    Science.gov (United States)

    Genuardi, M; Gasparini, P; Neri, G; Zelante, L

    1997-01-20

    The limb-pelvis hypoplasia/aplasia (LPHA) syndrome is a rare condition of skeletal malformations affecting the ulnae, pelvic bones, fibulae and femora, sometimes associated with extraskeletal defects. Most reported patients are from the Middle East, and autosomal recessive inheritance was clearly demonstrated on the basis of multiple occurrences of affected sibs born to consanguineous matings. Here we report on a baby girl presenting with the phenotypic characteristics of LPHA. This is second observation of LPHA from Italy, and the fourth outside the Middle East. A paternal first cousin once removed had unilateral fibular hypoplasia and absence of the the 4th and 5th digital rays. The possible link between these cases is discussed in the light of the developmental field theory.

  11. Successful rescue of pure red cell aplasia in two aged patients undergoing pancrease-kindey transplantation

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yin-fu; YANG Tong-han; WANG Qing-yu; Wang Ping-xian; Fan Ming-qi; Feng Jia-yu

    2001-01-01

    To explore the correlation between hypoimmunity and the occurrence of pure red cell aplasia (PRCA) in senile patients undergoing combined pancrease-kindey transplantation. Methods: PRCA occurred in 2 patients out of 5 who were performed combined pancrease-kindey transplantation.The general scheme of treatment mainly included selective administration of immunosuppressants and antivirus drugs, infusion of red blood cells on the basis of surveillance of parvorirus B19 and the ratio of T4 and T8 as well as the changes of the myelogram.Results: The myelogram of the patients returned to normal in 2 and 3 weeks after operation, respectively, and subsequent follow-up revealed no recurrence. Conclusion: This series illustrate the point that advanced age, hypo immunity, parvorirus B19 and immunosuppressants are vulnerable to PRCA. Combined treatment is an effectiveremedy for these patients.

  12. The MURCS Association: Mullerian Duct Aplasia, Renal Hypoplasia and Cervicothoracic Somite Dysplasia - A Case Report.

    Science.gov (United States)

    Akhter, N; Begum, B N; Newaz, M

    2015-07-01

    We report on a 22 years old lady with aplasia of uterus and most of the vagina with normal secondary sexual characteristics, unilateral renal hypoplasia and anomalies of cervico throacic somites (MURCS Association), growth retardation, cardiac defect and congenital urethrovaginal fistula. Although there is a broad spectrum of anomalies described with MURCS association genitourinary fistula is not yet reported and reviewed in published articles. The relevance of this paper is to show the importance of further investigation in cases of primary amenorrhoea with mullerian agenesis to establish that the patient has MURCS association and not simply MRKH (Mayer Rokitansky-Kusterhauser Syndrome) syndrome. Consequently we should provide guidance to the patients and their families about the best way to conduct the case including genetic counseling and family screening.

  13. A novel mutation in IRF6 resulting in VWS-PPS spectrum disorder with renal aplasia.

    Science.gov (United States)

    de Medeiros, Filipe; Hansen, Lars; Mawlad, Evete; Eiberg, Hans; Asklund, Camilla; Tommerup, Niels; Jakobsen, Linda P

    2008-06-15

    Popliteal pterygium syndrome (PPS) and Van der Woude syndrome (VWS) are caused by mutations in the gene interferon regulatory factor 6 (IRF6). Skeletal, genital malformations and involvement of the skin occur in PPS and orofacial clefting and lip pits occur in both. We report on a patient with unilateral cleft lip and palate, ankyloblepharon, paramedian lip pits, unilateral renal aplasia, and a coronal hypospadias. By sequencing IRF6, we detected a novel missense mutation (Arg339Ile). The other family members were unaffected and had no IRF6 mutations, including the patient's brother who was also born with hypospadias. The patient and his brother were both conceived by in vitro fertilization (IVF). It is discussed whether the renal malformation in the patient is related to the IVF procedure or to the IRF6 mutation.

  14. Antiepoetin antibody-related pure red cell aplasia: successful remission with cessation of recombinant erythropoietin alone.

    Science.gov (United States)

    Katagiri, Daisuke; Shibata, Maki; Katsuki, Takashi; Masumoto, Shoichi; Katsuma, Ai; Minami, Eri; Hoshino, Taro; Inoue, Tsuyoshi; Tada, Manami; Hinoshita, Fumihiko

    2010-10-01

    An elderly patient with pure red cell aplasia (PRCA) with antierythropoietin (anti-EPO) antibodies is described. PRCA due to alloimmunization is a rare and severe complication of recombinant human erythropoietin (rHu-EPO) therapy. Most reported patients with PRCA were cured primarily by immunosuppressive drug therapy. The patient in this case, however, did not want to receive any immunosuppressive drugs. Therefore, rHu-EPO injection was simply discontinued, the severe anemia gradually improved, and the hemoglobin approached normal range. This case is very rare and significant in that there have been few such elderly patients with rHu-EPO-induced PRCA in whom PRCA remission was achieved, with decreasing antibody titers, after cessation of rHu-EPO alone. Further cases are needed to assess how PRCA should be treated in patients with anti-EPO antibodies.

  15. Aplasia cutis congenita of the scalp with large underlying skull defect: a case report.

    Science.gov (United States)

    Leboucq, N; Montoya y Mártínez, P; Montoya-Vigo, F; Catan, P

    1994-08-01

    Localised agenesis of the scalp is the most frequent pattern in aplasia cutis congenita (ACC), a congenital absence of the skin and occasionally of deeper layers. Several clinical groups are characterised by the location and pattern of skin defects, associated malformations and the mode of inheritance. Death occurs in 20% of cases, secondary to the associated anomalies, to infections or to haemorrhage from ulceration of the sagittal sinus when there is also a defect of the underlying skull. In this latter case, we close the defect by two rotational scalp flaps (Orticochea technique) at birth. A three-dimensional CT study is useful for showing the extent of the skull defect and the deformity of the craniofacial complex and the changes in the bone after treatment.

  16. Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A.

    Science.gov (United States)

    Chang, Hyo Jeong; Sinn, Dong Hyun; Cho, Sung Gyun; Oh, Tae Hoon; Jeon, Tae Joo; Shin, Won Chang; Choi, Won Choong

    2014-06-01

    Pure red cell aplasia (PRCA) and autoimmune hemolytic anemia (AIHA) have rarely been reported as an extrahepatic manifestation of acute hepatitis A (AHA). We report herein a case of AHA complicated by both PRCA and AIHA. A 49-year-old female with a diagnosis of AHA presented with severe anemia (hemoglobin level, 6.9 g/dL) during her clinical course. A diagnostic workup revealed AIHA and PRCA as the cause of the anemia. The patient was treated with an initial transfusion and corticosteroid therapy. Her anemia and liver function test were completely recovered by 9 months after the initial presentation. We review the clinical features and therapeutic strategies for this rare case of extrahepatic manifestation of AHA.

  17. Bilateral submandibular gland aplasia with clinico-radiological mass due to prolapsing sublingual salivary tissue through mylohyoid boutonniere: a case report and review.

    Science.gov (United States)

    Ahmed, M; Strauss, M; Kassaie, A; Shotelersuk, V; DeGuzman, R

    2009-02-01

    Aplasia of major salivary glands is very rare. Compensatory hypertrophy of the rest of the glands can result in clinico-radiological masses. We present a report of a rare case of non-syndromic bilateral submandibular gland aplasia with hypertrophied sublingual salivary tissue, the latter herniating through mylohyoid boutonnière to present as a palpable mass on the left side with corresponding CT findings. Multiplanar evaluation is emphasised by utilizing multidetector CT.

  18. Prevention of pure red cell aplasia after major or bidirectional ABO blood group incompatible hematopoietic stem cell transplantation by pretransplant reduction of host anti-donor isoagglutinins

    OpenAIRE

    Stussi, G.; Halter, J; Bucheli, E; Valli, P V; Seebach, L; Gmür, J; Gratwohl, A; Passweg, J. R.; Seebach, J.D.

    2009-01-01

    BACKGROUND: Persistent anti-donor isoagglutinins after major ABO blood group incompatible hematopoietic stem cell transplantation may cause delayed red blood cell engraftment and post-transplant pure red cell aplasia. DESIGN AND METHODS: We investigated the effect of pretransplant anti-donor isoagglutinin reduction by in vivo absorption and/or plasmapheresis on the incidence of pure red cell aplasia and the time to red blood cell engraftment in 153 hematopoietic stem cell transplant recipient...

  19. Incidental finding of unilateral isolated aplasia of serratus anterior muscle and winged scapula on chest radiograph: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Joon Sung; Park, Hyun Jin; Ko, Jeong Min [Dept. of Radiology, St. Vincent' s Hospital, College of Medicine, The Catholic University of Korea, Suwon (Korea, Republic of)

    2014-10-15

    The isolated aplasia of the serratus anterior muscle with winging of scapula is very rare, and only a few cases are reported. Here, we present a case of a 30-year-old Korean male who initially presented with a left flank pain. His physical exam did not show any significant finding in his right shoulder. However, his chest radiograph showed absence of right serratus anterior muscle and slightly elevated and medially rotated right scapula. Subsequent CT scan showed the right serratus anterior muscle aplasia and medial winging of the right scapula. This case is unique in two aspects. First, the combination of abnormalities is different from the typical congenital abnormalities involving shoulder girdle, such as Sprengel deformity or Poland syndrome. Secondly, this was incidentally diagnosed with chest radiograph, without clinical impression. Careful reading of chest radiograph can help the radiologists to detect such clinically silent abnormalities.

  20. Pure red cell aplasia associated with recombinant erythropoietin: a case report and brief review of the literature.

    Science.gov (United States)

    Mohd Slim, M Atif; Shaik, Riaz

    2013-11-22

    Pure red cell aplasia (PRCA) is a rare adverse effect of recombinant erythropoietin (rEPO). Affected patients rapidly become transfusion-dependent, with many requiring immunosuppressive therapy for remission. We report a confirmed case in an elderly female, possibly the first of its kind in New Zealand, who was started on rEPO for anaemia of chronic kidney disease. We also briefly review current literature on rEPO-associated PRCA.

  1. Further development of a model of chronic bone marrow aplasia in the busulphan-treated mouse.

    Science.gov (United States)

    Turton, John A; Sones, William R; Andrews, Charles M; Pilling, Andrew M; Williams, Thomas C; Molyneux, Gemma; Rizzo, Sian; Gordon-Smith, Edward C; Gibson, Frances M

    2006-02-01

    Aplastic anaemia (AA) in man is an often fatal disease characterized by pancytopenia of the peripheral blood and aplasia of the bone marrow. AA is a toxic effect of many drugs and chemicals (e.g. chloramphenicol, azathioprine, phenylbutazone, gold salts, penicillamine and benzene). However, there are no widely used or convenient animal models of drug-induced AA. Recently, we reported a new model of chronic bone marrow aplasia (CBMA = AA) in the busulphan (BU)-treated mouse: eight doses of BU (10.50 mg/kg) were administered to female BALB/c mice over a period of 23 days; CBMA was evident at day 91/112 post-dosing with significantly reduced erythrocytes, platelets, leucocytes and nucleated bone marrow cell counts. However, mortality was high (49.3%). We have now carried out a study to modify the BU-dosing regime to induce CBMA without high mortality, and investigated the patterns of cellular responses in the blood and marrow in the post-dosing period. Mice (n = 64/65) were dosed 10 times with BU at 0 (vehicle control), 8.25, 9.0 and 9.75 mg/kg over 21 days and autopsied at day 1, 23, 42, 71, 84, 106 and 127 post-dosing (n = 7-15); blood and marrow samples were examined. BU induced a predictable bone marrow depression at day 1 post-dosing; at day 23/42 post-dosing, parameters were returning towards normal during a period of recovery. At day 71, 84, 106 and 127 post-dosing, a stabilized, late-stage, nondose-related CBMA was evident in BU-treated mice, with decreased erythrocytes, platelets and marrow cell counts, and increased MCV. At day 127 post-dosing, five BU-treated mice showed evidence of lymphoma. In this study, mortality was low, ranging from 3.1% (8.25 mg/kg BU) to 12.3% (9.75 mg/kg BU). It is concluded that BU at 9.0 mg/kg (or 9.25 mg/kg) is an appropriate dose level to administer (10 times over 21 days) to induce CBMA at approximately day 50-120 post-dosing.

  2. Aplasia transitória da série vermelha na anemia falciforme Transient red cell aplasia in sickle cell disease

    Directory of Open Access Journals (Sweden)

    Mônica P. A. Veríssimo

    2007-09-01

    Full Text Available A doença falciforme, devido à vida média encurtada das hemácias, pelo quadro de hemólise crônica, pode apresentar um quadro clínico grave de anemia quando ocorre supressão da eritropoese devida à infecção pelo Parvovírus humano B19. O quadro clínico apresenta-se com febre, que pode preceder a anemia grave, fraqueza e mal- estar, além de sinais laboratoriais como queda da hemoglobina e reticulocitopenia importante. Diagnóstico laboratorial pode ser por imunofluorescência ou ensaio enzimático. O tratamento é a transfusão de concentrado de hemácias. Pode haver complicações associadas a esta infecção, tais como seqüestro esplênico, seqüestro hepático, síndrome torácica aguda, síndrome nefrótica, meningoencefalite e acidente vascular cerebral. Estratégias de prevenção poderão mudar a morbi-mortalidade desta condição no paciente portador de doença falciforme.Sickle cell disease due to shortened life span of red blood cells by hemolysis, may present with severe anemia when erythropoietic suppression occurs due to infection by the Human parvovirus B19. The clinical presentation presents with fever, which may precede transient red cell aplasia, as well as laboratorial signs such as a drop in hemoglobin and significant reticulo cytopenia. Laboratorial diagnosis may be by immunofluorescence or enzymatic assays. Treatment is achieved by transfusion of packed red blood cells. Complications may be associated to this infection, including splenic and hepatic sequestration, acute chest syndrome, nephrotic syndrome, meningoencephalitis and strokes. Strategies of prevention are able to change the morbidity and mortality of this condition in sickle cell disease patients.

  3. Absence of Clinical and Hemodynamic Consequences due to Posterior Tibial Artery Congenital Aplasia

    Directory of Open Access Journals (Sweden)

    Georgios Karaolanis

    2015-01-01

    Full Text Available The exact knowledge of popliteal artery and its branches’ anatomic variations is important for the clinical practice of angiology, vascular surgery, and interventional procedures. Congenital absence of the artery leads, in some cases, to early malformations of the extremity in the childhood; however, it may also remain asymptomatic. We present an unusual case of a 76-year-old male patient complaining of paraesthesia in both limbs and bilateral aplasia of posterior tibial artery (PTA. Physical examination, ankle-brachial indexes, before and after exercise, arterial duplex scan, and magnetic resonance arteriography were performed. Arterial pulses for PTA at the level of the ankle were normal; arterial duplex study showed biphasic arterial flow at the level of the ankle. Color duplex ultrasound as well as magnetic resonance arteriography revealed the absence of the PTA in both limbs. The vascularization of the fibula was bilaterally normal. The patient underwent also neurological examination and electromyography, which were normal. The evaluation of the possible clinical signs and symptoms and the hemodynamic consequences of this condition are further discussed.

  4. [Relapse of autoimmune hemolytic anemia in Evans syndrome after thymectomy for pure red cell aplasia].

    Science.gov (United States)

    Higuchi, Masakazu; Osaki, Koichi; Yamano, Yujiro

    2007-06-01

    A 81-year-old woman was referred to our hospital with pure red cell aplasia (PRCA) associated with a thymoma in May 2005. She had previously suffered from Evans syndrome which had been improved by prednisolone in 1999. She underwent a thymectomy, however her anemia subsequently got worse. Reticulocytopenia was noted and a marrow erythroid series was aplastic. Furthermore, both direct and indirect Coombs tests were positive, and the serum haptoglobin level was low. Based on these findings, the patient was diagnosed as having PRCA complicated with relapsed autoimmune hemolytic anemia (AIHA). The PRCA and AIHA were successfully treated with prednisolone and cyclosporine. To our knowledge, only one case of the PRCA complicated with AIHA after thymectomy has been reported. FoxP3 positive regulatory T-cells (Treg), which maintain immunological self-tolerance, were readily detectable in the excised thymoma. Thus, thymectomy resulted in removal of the Treg pool and might explain the autoimmune activation, believed to be one of the mechanisms of the post-thymectomy recurrence of the AIHA in this case.

  5. [Pure red cell aplasia and hypogammaglobulinemia after administration of Dioscorea rhizome and Poria cocos].

    Science.gov (United States)

    Sato, Takayuki; Ueda, Yasunori

    2015-11-01

    A 56-year-old woman was referred to our department for detailed examination of anemia. She was diagnosed with pure red cell aplasia (PRCA) associated with severe reticulocytopenia based on blood testing and severe erythroblastopenia based on bone marrow aspiration. Blood tests revealed severe hypogammaglobulinemia, but monoclonal protein was not detected in either serum or urine by immunoelectrophoresis. Plasma cells were not increased in bone marrow aspirates or the biopsy specimen. Neither osteolytic lesions nor plasmacytoma was detected by computed tomography. We thus ruled out multiple myeloma. She had been treated with various Chinese herbal medicines prescribed at the referring hospital. We suspected PRCA induced by one of the Chinese herbal medicines and completely discontinued all of these herbal preparations. Hematologic testing revealed that the reticulocyte count and hemoglobin concentration began to recover on day 7 and the hemoglobin concentration and IgG levels had reached reference ranges on day 73 after discontinuation of the Chinese herbal medicines. We suspected Sanyaku (Dioscorea rhizome) or Bukuryou (Poria cocos) to have induced PRCA and hypogammaglobulinemia in this patient. To the best of our knowledge, this is the first report of PRCA and hypogammaglobulinemia induced by a Chinese herbal medicine. Clinicians must consider the possibility of drug-induced PRCA and hypogammaglobulinemia in patients taking Chinese herbal preparations.

  6. Alberto Fujimori : le populisme de l’efficacité

    Directory of Open Access Journals (Sweden)

    Diana Burgos-Vigna

    2005-09-01

    Full Text Available À la tête du Pérou de 1990 à 2000, Alberto Fujimori a su rester populaire en combinant les recettes traditionnelles et nouvelles du populisme. Le discrédit des partis politiques et des syndicats a constitué un contexte favorable à l’arrivée et au maintien au pouvoir de ce non-professionnel de la politique, auquel des valeurs d’honnêteté et de compétence ont été spontanément prêtées. Le chef d’Etat péruvien a construit en outre, tout au long de ses mandats successifs, une stratégie politique destinée à asseoir sa légitimité. Cette stratégie s’est fondée sur des actions telles que : la mise en place d’une relation directe et quasi affective avec les couches les plus défavorisées de la population par le biais de pratiques clientélistes ; la déstructuration du tissu social dans l’objectif d’éviter toute opposition et de renforcer le pouvoir du chef de l’Etat ; l’instrumentalisation de certains groupes d’acteurs, notamment par l’intermédiaire des programmes sociaux ; enfin, le contrôle permanent, et sans cesse renforcé, de l’information, via la surveillance des médias et des opposants. Fondée sur une image d’efficacité, la gestion politique d’Alberto Fujimori est demeurée populaire jusqu’à la fin des années 1990, lorsque la révélation d’affaires de corruption a accéléré la chute de son régime.Presidente de Perú de 1990 a 2000, Alberto Fujimori supo conservar su popularidad mezclando viejas y nuevas recetas del populismo. El descrédito de los partidos políticos y de los sindicatos dibujó el contexto idóneo a la llegada y al mantenimiento al poder de este outsider de la política, al cual muy pronto fueron asociados valores de honestidad y de competencia. El jefe del Estado peruano supo además, a lo largo de sus mandatos sucesivos, construir una estrategia política cuyo objetivo era el asentamiento de su legitimidad. Esta estrategia se fundó principalmente en las

  7. PROPOSITION D'UN MODELE DE L'EFFICACITE DU CO-COMMISSARIAT AUX COMPTES DANS LES SOCIETES ANONYMES COTEES FRANÇAISES

    OpenAIRE

    Jeannette Bennecib

    2002-01-01

    Si le commissariat aux comptes est une institution reconnue par un large public, le co-commissariat aux comptes semble ignoré. Dans un contexte de remise en cause de la crédibilité des informations financières et de l'opinion de l'auditeur, nous nous interrogeons sur l'efficacité d'un double contrôle dans les SA cotées françaises. A partir du cadre conceptuel normatif de l'efficacité du cocommissariat aux comptes, nous proposons un modèle explicatif fondé sur le principe d'indépendance en app...

  8. Une mesure par simulations de l'efficacité de distribution de la liquidité dans les réseaux interbancaires

    OpenAIRE

    Stéphane Vivier-Lirimont; Anton Granik

    2011-01-01

    Cet article vise à discriminer les réseaux interbancaires dans leur efficacité relative à distribuer la liquidité entre les banques en fonction de différentes architectures de réseaux possibles. L’analyse réalisée par simulations dans une économie bancaire fictive simplifiée se fonde sur deux indicateurs d’efficacité relative : l’une en termes de processus, l’autre en termes de résultats. Les vitesses de transactions, le nombre d’échanges et le rythme de décroissance du nombre de banques illi...

  9. Etude microdosimetrique de l'influence des materiaux sur l'efficacite biologique d'une source d'iode-125

    Science.gov (United States)

    Taschereau, Richard

    Cette these concerne les implants permanents pour la prostate. Les isotopes employes, le 103Pd et l'125I, semblent produire les memes resultats cliniques: le premier a cause d'une radiation plus efficace et le second a cause de sa demi-vie plus longue. La recherche utilise le cadre theorique de la microdosimetrie et des simulations Monte Carlo. Elle propose d'employer le spectre d'ejection dans le calcul de l'efficacite; ce changement fait passer l'efficacite relative du 103Pd de 10% a 5%. Elle montre ensuite qu'il est possible d'ameliorer l'efficacite de la radiation de 125I par l'exploitation des rayons X caracteristiques de la capsule. Une source amelioree faite de molybdene et d'yttrium est donnee en exemple. Elle procure une radiation de 5--7% plus efficace, ce qui surclasse les deux sources existantes. Les applications ne se limitent pas au traitement de la prostate; le traitement du melanome oculaire et la curietherapie endovasculaire pourraient en beneficier.

  10. Améliorer votre efficacité techniques d'aujourd'hui pour en faire plus en moins de temps

    CERN Document Server

    Savoyat, Bruno

    2012-01-01

    Quels que soient votre fonction, votre métier ou votre mission dans l'entreprise, ce livre pragmatique peut vous ouvrir les chemins d'une nouvelle vie. Il a été conçu et écrit pour vous rendre service et pour vous aider à gagner en efficacité. Les meilleures pratiques y ont été retenues pour vous. Certaines sont utilisées avec succès par plus d'un million de personnes à travers le monde. Leur mise en oeuvre est simple pour un impact maximal sur votre productivité, sur la qualité de votre travail et sur la satisfaction que vous retirerez de votre quotidien professionnel. Les principes et les conseils d'efficacité décrits dans ce livre peuvent être appliqués seul comme en équipe, et être généralisés à l'ensemble d'une entreprise. Vous pouvez choisir de les découvrir par une lecture du début à la fin, qui vous permettra une révision systématique de votre manière de travailler et de votre potentiel de gains en efficacité. Mais vous pouvez également opter pour une découverte théma...

  11. Noncanonical Wnt5a-Ca(2+) -NFAT signaling axis in pesticide induced bone marrow aplasia mouse model: A study to explore the novel mechanism of pesticide toxicity.

    Science.gov (United States)

    Chattopadhyay, Sukalpa; Chatterjee, Ritam; Law, Sujata

    2016-10-01

    According to case-control studies, long-term pesticide exposure can cause bone marrow aplasia like hematopoietic degenerative disease leading to impaired hematopoiesis and increased risk of aplastic anemia in human subjects. However, the exact mechanism of pesticide mediated hematotoxicity still remains elusive. In this study, we investigated the role of noncanonical Wnt signaling pathway, a crucial regulator of adult hematopoiesis, in pesticide induced bone marrow aplasia mouse model. Aplasia mouse model was developed following inhalation and dermal exposure of 5% aqueous mixture of common agriculturally used pesticides for 6 h/day for 5 days a week up to 90 days. After that, blood hemogram, marrow smear, cellularity, scanning electron microscopy, extramedullary hematopoiesis and flowcytometric expression analysis of noncanonical Wnt signaling components, such as Wnt 5a, fzd5, NFAT, IFN-γ, intracellular Ca(2+) level were evaluated in the bone marrow hematopoietic stem/progenitor compartment of the control and pesticide induced aplasia groups of animals. Results showed that pesticide exposed mice were anemic with peripheral blood pancytopenia, hypocellular degenerative marrow, and extramedullary hematopoiesis in the spleen. Upon pesticide exposure, Wnt 5a expression was severely downregulated with a decline in intracellular Ca(2+) level. Moreover, downstream of Wnt5a, we observed sharp downregulation of NFATc2 transcription factor expression, the major target of pesticide toxicity and its target molecule IFN-γ. Taken together, our result suggests that deregulation of Wnt5a-Ca(2+) -NFAT signaling axis in the hematopoietic stem/progenitor compartment plays a crucial role behind the pathogenesis of pesticide mediated bone marrow aplasia by limiting primitive hematopoietic stem cells' ability to maintain hematopoietic homeostasis and reconstitution mechanism in vivo during xenobiotic stress leading to ineffective hematopoiesis and evolution of bone marrow aplasia.

  12. A patient with isochromosome 18q, radial-thumb aplasia, thrombocytopenia, and an unbalanced 10;18 chromosome translocation.

    Science.gov (United States)

    Sahoo, Trilochan; Naeem, Rizwan; Pham, Kim; Chheng, Sou; Noblin, Sarah T; Bacino, Carlos A; Gambello, Michael J

    2005-02-15

    We report on the clinical and cytogenetic findings in a newborn with a de novo isochromosome 18q. Radial/thumb aplasia and thrombocytopenia were significant features in addition to multiple congenital anomalies. Comparison with reported cases suggests that the genes for such features are located on the 18q arm. An additional finding of a non-reciprocal translocation between chromosome 18p telomere and chromosome 10q telomere was also observed in a majority of cells examined. This additional rearrangement likely has minimal phenotypic consequences, but does raise the possibility that cryptic translocations of telomeric ends of the deleted arm in isochromosome cases may be more common than appreciated.

  13. Linezolid-induced pure red cell aplasia in a patient with Staphylococcus epidermidis infection after allogeneic stem cell transplantation.

    Science.gov (United States)

    Waki, F; Ohnishi, H; Shintani, T; Uemura, M; Matsumoto, K; Fukumoto, T; Kitanaka, A; Kubota, Y; Tanaka, T; Ishida, T; Matsunaga, T

    2012-08-01

    Linezolid (LZD) is the first oxazolidinone antibiotic that is effective against drug-resistant gram-positive organisms. Hematological toxicities such as thrombocytopenia, anemia, and leukocytopenia are common in LZD therapy. However, LZD-induced pure red cell aplasia (PRCA) is very rare. A 56-year-old man with myelodysplastic syndrome underwent allogeneic bone marrow transplantation from a human leukocyte antigen-matched and ABO blood type-matched unrelated male donor. He had bacteremia caused by Staphylococcus epidermidis after engraftment of neutrophils and red blood cells. We first administered vancomycin, but then changed to intravenous LZD because of kidney damage. Two weeks after LZD therapy, the patient's hemoglobin and reticulocyte levels were 6.8 g/dL and 0.3%, respectively. Bone marrow examination revealed red blood cell aplasia (myeloid/erythroid ratio was 402). The patient showed rapid recovery of normal erythropoiesis within 2 weeks of LZD cessation. It is important to be aware of the hematological effects associated with LZD in the setting of stem cell transplantation,particularly for those with pre-existing myelosuppression, renal insufficiency, and those receiving concomitant drugs that produce bone marrow suppression. We advocate that a reticulocyte count be performed periodically for detecting bone marrow suppression, including PRCA, during LZD therapy.

  14. Aplasia medular após transplante hepático em pediatria Aplastic anemia after pediatric liver transplantation

    Directory of Open Access Journals (Sweden)

    Marlene P. Garanito

    2009-01-01

    Full Text Available A aplasia de medula é uma das mais raras (Aplastic anemia (AA is one of the rarest (<1% and most serious complications of liver transplantation for fulminant non-A, non-B and non-C hepatitis. It was first described in 1987 by Stock; the mechanism involved is an immunologically mediated condition secondary to an unknown viral infection. The disease is associated with a dismal prognosis. Spontaneous recovery from acquired AA is very rare however some patients (50-70% recover after immunosuppressive therapy, such as Cyclosporin A (CsA and Antithymocyte globulin (ATG, even after liver transplantation. Another treatment option is bone marrow transplantation. We report on a child who developed AA following liver transplantation for fulminant viral hepatitis that was treated with intensive immunosuppression including CsA and ATG and achieved complete recovery.

  15. Deferasirox treatment improved hematopoiesis and led to complete remission in a patient with pure red cell aplasia.

    Science.gov (United States)

    Kojima, Minoru; Machida, Shinichiro; Sato, Ai; Miyamoto, Mitsuki; Moriuchi, Makiko; Ohbayashi, Yoshiaki; Ando, Kiyoshi

    2013-12-01

    A 64-year-old woman developed pure red cell aplasia (PRCA) 4 years after thymectomy for thymoma. During anti-thymocyte globulin treatment, the patient developed cytomegalovirus pneumonia and was thus unable to continue immunosuppressive therapy and became transfusion dependent. Deferasirox was started for treatment with iron overload when serum ferritin increased to >1000 ng/mL. Seven months after initiation of deferasirox treatment, serum ferritin level decreased the normal range and the patient has remained transfusion independent thereafter. Deferasirox was discontinued when serum ferritin level decreased below 500 ng/mL, and she has maintained in complete remission over the last 15 months. Hypotheses have been raised regarding the improvement of hematopoiesis by deferasirox treatment, but the mechanism whereby this might be achieved remains unclear. Deferasirox treatment may be clinically beneficial both by reducing iron overload and by improving hematopoiesis in patients with PRCA.

  16. Utero-vaginal aplasia (Mayer-Rokitansky-Küster-Hauser syndrome associated with deletions in known DiGeorge or DiGeorge-like loci

    Directory of Open Access Journals (Sweden)

    Odent Sylvie

    2011-03-01

    Full Text Available Abstract Background Mayer-Rokitansky-Küster-Hauser (MRKH syndrome is characterized by congenital aplasia of the uterus and the upper part of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. The uterovaginal aplasia is either isolated (type I or more frequently associated with other malformations (type II or Müllerian Renal Cervico-thoracic Somite (MURCS association, some of which belong to the malformation spectrum of DiGeorge phenotype (DGS. Its etiology remains poorly understood. Thus the phenotypic manifestations of MRKH and DGS overlap suggesting a possible genetic link. This would potentially have clinical consequences. Methods We searched DiGeorge critical chromosomal regions for chromosomal anomalies in a cohort of 57 subjects with uterovaginal aplasia (55 women and 2 aborted fetuses. For this candidate locus approach, we used a multiplex ligation-dependent probe amplification (MLPA assay based on a kit designed for investigation of the chromosomal regions known to be involved in DGS. The deletions detected were validated by Duplex PCR/liquid chromatography (DP/LC and/or array-CGH analysis. Results We found deletions in four probands within the four chromosomal loci 4q34-qter, 8p23.1, 10p14 and 22q11.2 implicated in almost all cases of DGS syndrome. Conclusion Uterovaginal aplasia appears to be an additional feature of the broad spectrum of the DGS phenotype. The DiGeorge critical chromosomal regions may be candidate loci for a subset of MRKH syndrome (MURCS association individuals. However, the genes mapping at the sites of these deletions involved in uterovaginal anomalies remain to be determined. These findings have consequences for clinical investigations, the care of patients and their relatives, and genetic counseling.

  17. Energy efficiency; Efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-06-15

    This road-map proposes by the Group Total aims to inform the public on the energy efficiency. It presents the energy efficiency and intensity around the world with a particular focus on Europe, the energy efficiency in industry and Total commitment. (A.L.B.)

  18. Amelioration de l'efficacite energetique du procede d'electrolyse de l'aluminium conception d'un nouveau bloc cathodique

    Science.gov (United States)

    Blais, Mathieu

    Au Quebec, les alumineries sont de grandes consommatrices d'energie electrique, soit pres de 14 % de la puissance installee d'Hydro-Quebec. Dans ce contexte, des petits gains en efficacite energetique des cuves d'electrolyse pourraient avoir un impact important sur la reduction globale de la consommation d'electricite. Le projet de maitrise decrit dans cette etude repond a la problematique suivante : comment l'optimisation de la geometrie d'un bloc cathodique en vue d'uniformiser la densite de courant peut augmenter l'efficacite energetique et la duree de vie de la cuve d'aluminium? Le but premier du projet est de modifier la geometrie en vue d'ameliorer le comportement thermoelectrique des blocs cathodiques et d'accroitre par le fait meme l'efficacite energetique du procede de production d'aluminium. La mauvaise distribution de la densite de courant dans la cuve est responsable de certains problemes energetiques ayant des impacts negatifs sur l'economie et l'environnement. Cette non-uniformite de la distribution du courant induit une usure prematuree de la surface de la cathode et contribue a reduire la stabilite magnetohydrodynamique de la nappe de metal liquide. Afin de quantifier les impacts que peut avoir l'uniformisation de la densite de courant a travers le bloc cathodique, un modele d'un bloc cathodique d'une cuve de la technologie AP-30 a ete concu et analyse par elements finis. A partir de son comportement thermoelectrique et de donnees experimentales d'une cuve AP-30 tirees de la litterature, une correlation entre le profil de densite de courant a la surface du bloc et le taux d'erosion local au meme endroit a ete creee. Cette relation correspond au modele predictif de la duree de vie de tout bloc du meme materiau a partir de son profil de densite de courant. Ensuite, une programmation a ete faite incorporant dans une meme fonction cout les impacts economiques de la duree de vie, de la chute de voltage cathodique et de l'utilisation de nouveaux materiaux

  19. Metabolism of {sup 137}cesium, {sup 137}barium in the rat. Therapeutics of the contamination; Metabolisme du {sup 137}cesium, {sup 137}baryum chez le rat. Therapeutique de la contamination

    Energy Technology Data Exchange (ETDEWEB)

    Remy, J.; Philippon, A.; Lafuma, J.; Walter, C. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Departement de la Protection Sanitaire, Laboratoire de Radiopathologie

    1967-07-01

    'elimination du {sup 137}Cs - {sup 137}Ba chez le rat. Ils montrent l'independance de ces phenomenes vis-a-vis des modalites d'une administration unique. La distribution tend dans tous les cas vers un schema type qui se maintient ensuite identique a lui-meme en fonction de la charge corporelle. L'analyse biochimique de l'etat du cesium dans les milieux biologiques montre qu'il y est transporte sous une forme libre et ionisee. Abordant le probleme du mode de penetration de l'ion cesium dans le milieu intracellulaire et notamment par l'etude cinetique du systeme plasma-hematie in vivo et in vitro, les auteurs adoptent l'hypothese d'un transport actif du cesium par la membrane cellulaire. Ils en arrivent ainsi a un schema general de la distribution du cesium dans l'organisme, essentiellement caracterise par un equilibre dynamique de repartition entre deux compartiments: 99 pour cent du cesium est accumule dans le pool intracellulaire, 1 pour cent dans les liquides extracellulaires. Ce dernier compartiment est ouvert sur les emonctoires. Du fait du transport actif par les membranes cellulaires, la charge du pool intracellulaire est rapide, mais la decharge est lente. Ce phenomene est le facteur limitant de la decroissance de la charge corporelle. De ce schema les auteurs deduisent les raisons de l'echec relatif des diverses voies therapeutiques explorees a ce jour par eux-memes, et par d'autres auteurs. La stimulation des emonctoires naturels, dans le cas des diuretiques par exemple, ne saurait accroitre que l'epuration du compartiment extracellulaire. Or ce dernier ne contient que 1 pour cent de la charge corporelle et sa recharge est lente. En outre, les procedes visant a contrarier ou inhiber le transport actif du cesium par la membrane cellulaire restent, a ce jour, incompatibles avec la survie de la cellule. (auteurs)

  20. Pure red cell aplasia accompanied by autoimmune hemolytic anemia in a patient with type A viral hepatitis.

    Science.gov (United States)

    Koiso, Hiromi; Kobayashi, Satsuki; Ueki, Kazue; Hamada, Tetsuya; Tsukamoto, Norifumi; Karasawa, Masamitsu; Murakami, Hirokazu; Nojima, Yoshihisa

    2009-05-01

    A rare case of acute hepatitis A associated with autoimmune hemolytic anemia (AIHA) and pure red cell aplasia (PRCA) is reported. A 55-year-old woman consulted a doctor because of common cold-like symptoms and she was referred to our hospital in January 2007. Laboratory findings showed a marked elevation of serum transaminase and total bilirubin levels (AST 9,605 IU/l, ALT 5,546 IU/l and T-bil 4.14 mg/dl), and prolonged prothrombin time, findings which suggested the risk of progression to fulminant hepatitis, and she was treated with plasmapheresis and hemodialysis filtration on the first and second hospital days. She was diagnosed with severe acute hepatitis A based on the elevation of serum IgM anti-hepatitis A virus. On the 20th hospital day, her hemoglobin level began to decrease in spite of improving transaminase levels without any signs of gastrointestinal bleeding. Bilirubin and LDH elevation, haptoglobin decline and a positive direct Coombs test were detected and these findings indicated AIHA complication; however, the reticulocyte count decreased and bone marrow showed marked erythroid hypoplasia so the co-existence of PRCA was diagnosed. After oral prednisolone administration (1 mg/kg/day), her hemolytic anemia rapidly improved.

  1. Analyse de l'activité et développement de l'auto-efficacité : Un levier pour la professionnalisation des étudiants en sciences infirmières au Liban

    OpenAIRE

    Khawand Ayle, Ghada; Nagels, Marc

    2014-01-01

    International audience; Dans le cadre de la réingénierie de la formation infirmière dans une université au Liban, l’étude montre que l’analyse de l’activité est un facteur de développement de l’auto-efficacité pour la conception d’un projet de soins chez les étudiants. L'auto-efficacité d’un individu se présente essentiellement comme une évaluation personnelle de sa compétence pour agir dans une classe de situations donnée. Ce sentiment de compétence perçue par le professionnel ou l’étudiant ...

  2. Alteration of hedgehog signaling by chronic exposure to different pesticide formulations and unveiling the regenerative potential of recombinant sonic hedgehog in mouse model of bone marrow aplasia.

    Science.gov (United States)

    Chaklader, Malay; Law, Sujata

    2015-03-01

    Chronic pesticide exposure-induced downregulation of hedgehog signaling and its subsequent degenerative effects on the mammalian hematopoietic system have not been investigated yet. However a number of concurrent studies have pointed out the positive correlation between chronic pesticide exposure induced bone marrow failure and immune suppression. Here, we have given an emphasis on the recapitulation of human marrow aplasia like condition in mice by chronic mixed pesticide exposures and simultaneously unravel the role of individual pesticides in the said event. Unlike the effect of mixed pesticide, individual pesticides differentially alter the hedgehog signaling in the bone marrow primitive hematopoietic compartment (Sca1 + compartment) and stromal compartment. Individually, hexaconazole disrupted hematopoietic as well as stromal hedgehog signaling activation through inhibiting SMO and facilitating PKC δ expression. On contrary, both chlorpyriphos and cypermethrin increased the sequestration and degradation of GLI1 by upregulating SU(FU) and βTrCP, respectively. However, cypermethrin-mediated inhibition of hedgehog signaling has partly shown to be circumvented by non-canonical activation of GLI1. Finally, we have tested the regenerative response of sonic hedgehog and shown that in vitro supplemented recombinant SHH protein augmented clonogenic stromal progenitors (CFU-F) as well as primitive multipotent hematopoietic clones including CFU-GEMM and CFU-GM of mixed pesticide-induced aplastic marrow. It is an indication of the marrow regeneration. Finally, our findings provide a gripping evidence that downregulated hedgehog signaling contribute to pesticide-mediated bone marrow aplasia but it could be recovered by proper supplementation of recombinant SHH along with hematopoietic base cocktail. Furthermore, SU(FU) and GLI1 can be exploited as future theradiagnostic markers for early marrow aplasia diagnosis.

  3. Pure red cell aplasia caused by pegylated interferon-α-2a plus ribavirin in the treatment of chronic hepatitis C

    Institute of Scientific and Technical Information of China (English)

    Cheng-Shyong Chang; Sheng-Lei Yan; Hsuan-Yu Lin; Fu-Lien Yu; Chien-Yu Tsai

    2011-01-01

    Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia, reticulocytopenia and almost complete absence of erythroid precursors in bone marrow. The pathophysiology of PRCA may be congenital or acquired. To our knowledge, there is only one case report in the English literature of PRCA after pegylated interferon combination therapy for chronic hepatitis C. We report a second case of PRCA after pegylated interferon combination treatment for chronic hepatitis C. The diagnosis of PRCA was confirmed by the typical findings of bone marrow biopsy. The possible etiologies of our case are also discussed in this paper.

  4. Coombs-negative Autoimmune Hemolytic Anemia Followed by Anti-erythropoetin Receptor Antibody-associated Pure Red Cell Aplasia: A Case Report and Review of Literature.

    Science.gov (United States)

    Yoshimi, Mayumi; Kadowaki, Yutaka; Kikuchi, Yuji; Takahashi, Tsuyoshi

    2016-01-01

    A 76-year-old woman was referred to our hospital because of anemia. The laboratory findings revealed hemolysis. Although a direct Coombs test was negative, a high titer of RBC-bound IgG was detected, and a diagnosis of Coombs-negative autoimmune hemolytic anemia was made. She was successfully treated with prednisolone. One year and five months later, she again presented anemia and was diagnosed with pure red cell aplasia. Anti-erythropoietin receptor antibody was detected in the serum. She was treated with cyclosporine and obtained prompt recovery. We herein report this rare case and review the pertinent literature.

  5. Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia.

    Science.gov (United States)

    Dao, An T T; Yamazaki, Hirohito; Takamatsu, Hiroyuki; Sugimori, Chiharu; Katagiri, Takamasa; Maruyama, Hiroyuki; Zaimoku, Yoshitaka; Maruyama, Kana; Ly, Trung Q; Espinoza, Luis; Nakao, Shinji

    2016-04-01

    Most patients with acquired pure red cell aplasia (PRCA) and some with acquired aplastic anemia (AA) respond well to cyclosporine (CsA), but thereafter often show CsA dependency. The mechanism underlying this dependency remains unknown. We established a reliable method for measuring the regulatory T cell (Treg) count using FoxP3 and Helios expression as markers and determined the balance between Tregs and other helper T cell subsets in 16 PRCA and 29 AA patients. The ratios of interferon-γ-producing CD4(+) (Th1) T cells to Tregs in untreated patients and CsA-dependent patients were significantly higher (PRCA 5.77 ± 1.47 and 7.38 ± 2.58; AA 6.18 ± 2.35 and 8.94 ± 4.06) than in healthy volunteers (HVs; 3.33 ± 0.90) due to the profound decrease in the percentage of Tregs. In contrast, the ratios were comparable to HVs in convalescent CsA-treated AA patients (4.74 ± 2.10) and AA patients in remission after the cessation of CsA treatment (4.24 ± 1.67). Low-dose CsA (100 ng/ml) inhibited the proliferation of conventional T cells (Tconv) to a similar degree to the inhibition by Tregs in a co-culture with a 1:1 Treg/Tconv ratio. The data suggest that CsA may reverse the hematopoietic suppression in PRCA and AA patients by compensating for the inadequate immune regulatory function that occurs due to a profound decrease in the Treg count.

  6. Analysis of the energy efficiency of the transport system in Algeria; Analyse de l'efficacite energetique du systeme de transport en Algerie

    Energy Technology Data Exchange (ETDEWEB)

    Hamdani, Sid Ahmed

    2010-09-15

    The objective of this communication is analyze the energy efficiency of the transport system in Algeria and to show the areas of possible rationalization in this sector. Our approach is to analyze the existing configuration of the sector and its impact on energy consumption, by developing a sectional model Bottom Up, where the transport park has been modified by the means used. We have shown that the potential to improve the transport system energy efficiency is important and have recommended some options aimed at the sector organisation and aimed at increasing the relative part of transport systems to make it more energy efficient. [French] L'objectif de cette communication est d'analyser l'efficacite energetique du systeme de transport algerien et de montrer les gisements de rationalisation possibles dans ce secteur. Notre approche consiste a analyser la configuration existante du secteur et son impact sur la consommation d'energie, en elaborant un modele sectoriel Bottom Up, ou le parc de transport a ete desagrege par moyen utilise. Nous avons montre que le potentiel d'amelioration de la performance energetique du systeme de transport est important et avons recommande quelques options ciblant l'organisation du secteur et visant a augmenter la part relative de moyens de transport plus efficace energetiquement.

  7. New experimental approach to treatment of radiation-induced bone marrow aplasia: ex vivo expansion of hematopoietic cells; Nouvelle approche experimentale du traitement de l`aplasie medullaire radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Mathieu, J.; Drouet, M.; Grenier, N.; Grange, L.; Bourin, P.; Vetillard, J.; Thierry, D.; Mestries, J.C.

    1995-12-31

    The management of bone marrow aplasia secondary to accidental exposure to high doses of ionizing radiations requires new therapeutic protocols in addition to cytokine therapy. The in vitro incubation of hematopoietic stem and progenitor cells from irradiated nonhuman primates with negative and positive regulators of hematopoiesis may lead to helpful products of transfusion. (author).

  8. L’efficacité du conseil d’administration dans les sociétés anonymes au Cameroun: Une lecture par l’hétérogénéité des administrateurs

    Directory of Open Access Journals (Sweden)

    Georges Kriyoss Mfouapon

    2013-12-01

    Full Text Available Le but de cet article est d’analyser l’effet de l’homogénéité ou de l’hétérogénéité du profil des administrateurs sur l’efficacité de leur conseil d’administration (CA. Les données analysées sont collectées auprès de 386 administrateurs répartis sur un échantillon de 64 CA des sociétés anonymes (SA installées au Cameroun. Les résultats obtenus indiquent que l’homogénéité socioprofessionnelle, de l’indépendance et clanique du CA sont d’une influence notable sur leur efficacité. Ces résultats montrent, en fait que, l’hétérogénéité du CA est source d’efficacité supérieure dans les choix stratégiques, et d’inefficacité dans les opérations de contrôle et de surveillance de l’équipe dirigeante. Ces résultats s’inscrivent dans la même perspective que les travaux d’Hambrick & Mason (1984 sur la Upper Echelons Research, la théorie de la régulation clanique d’Ouchi (1980 et constituent en même temps une confirmation des résultats de Jensen (1993.

  9. Efficacité des moyens de traitement physiothérapeutiques pour l'équilibre assis dynamique chez les patients souffrant d'une lésion médullaire

    OpenAIRE

    Laurent, Ailsa; Morel, Florence; Currat, Damien

    2014-01-01

    Introduction : afin d’acquérir et de maintenir leur autonomie, les patients souffrant de lésion médullaire doivent améliorer leur équilibre assis, pré requis pour réaliser les Activités de la Vie Quotidienne. Notre objectif est de déterminer quels sont les moyens physiothérapeutiques à disposition pour travailler l’équilibre assis dynamique chez cette population et quelles sont leurs preuves d’efficacité selon le stade de réadaptation (aigu/chronique). Méthodologie : nous avons inclus des étu...

  10. Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab.

    Science.gov (United States)

    Kako, Shinichi; Kanda, Yoshinobu; Oshima, Kumi; Nishimoto, Nahoko; Sato, Hiroyuki; Watanabe, Takuro; Hosoya, Noriko; Motokura, Toru; Miyakoshi, Shigesaburo; Taniguchi, Shuichi; Kamijo, Aki; Takahashi, Koki; Chiba, Shigeru; Kurokawa, Mineo

    2008-03-01

    Hemolytic anemia and pure red cell aplasia (PRCA) after allogeneic hematopoietic stem cell transplantation (HSCT) have been reported to be mainly related to ABO-incompatibility between donor and recipient. Autoimmune hemolytic anemia (AIHA) without ABO-incompatibility has been also reported after allogeneic HSCT, especially with T-cell depletion. However, optimal management of AIHA or PRCA remains unclear. A 54-year-old male with myelodysplastic syndrome (MDS) underwent haploidentical human leukocyte antigen-mismatched HSCT using in vivo alemtuzumab and developed AIHA and PRCA simultaneously 15 months after transplantation, following the administration of cidofovir and probenecid for persistent cytomegalovirus (CMV) antigenemia and retinitis. AIHA was successfully treated with rituximab, and subsequently PRCA with cyclosporine without relapse of MDS or recurrence of CMV infection. The clinical course suggested that AIHA was mainly caused by humoral immune response, while PRCA was mainly caused by cell-mediated immune response in this patient, although these immune responses might be related to each other.

  11. Primary Sjögren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis.

    Science.gov (United States)

    Komaru, Yohei; Higuchi, Takakazu; Koyamada, Ryosuke; Haji, Youichiro; Okada, Masato; Kamesaki, Toyomi; Okada, Sadamu

    2013-01-01

    A 36-year-old woman presented with hemolytic anemia without a reticulocyte response 38 days after delivery. A marked reduction in erythroid cells and an increase in macrophages with active hemophagocytosis were noted in the bone marrow. While conventional Coombs' tests were negative, the level of red blood cell (RBC)-bound immunoglobulin G (IgG) was increased. The patient was diagnosed with primary Sjögren syndrome (pSS) based on her symptoms, positive anti-SS-A antibodies, Coombs-negative autoimmune hemolytic anemia and pure red cell aplasia associated with RBC-bound IgG and hemophagocytosis. The unique presentation was considered to be a consequence of immunological derangement associated with pSS, pregnancy and delivery.

  12. Bone marrow pathology in dogs and cats with non-regenerative immune-mediated haemolytic anaemia and pure red cell aplasia.

    Science.gov (United States)

    Weiss, D J

    2008-01-01

    Many dogs and cats with immune-mediated haemolytic anaemia (IMHA) lack a bone marrow erythroid regenerative response. To better understand the failure of the bone marrow to respond to the anaemia, bone marrow pathology associated with non-regenerative IMHA and pure red cell aplasia (PRCA) was reviewed. Eighty-two affected dogs and 57 affected cats were identified from a population presenting to a referral hospital over a 10-year period. Fifty-five dogs had non-regenerative IMHA (38 had bone marrow erythroid hyperplasia and 17 had erythroid maturation arrest) and 27 had pure red cell aplasia (PRCA). Twenty-eight cats had non-regenerative IMHA (24 had erythroid hyperplasia and 4 had erythroid maturation arrest) and 29 had PRCA. A variety of pathological changes were observed in bone marrow aspirates and core biopsy specimens taken from these animals. These changes included dysmyelopoiesis, myelonecrosis, myelofibrosis, interstitial oedema, haemorrhage, acute inflammation, haemophagocytic syndrome, lymphocyte aggregation, and lymphocyte or plasma cell hyperplasia. In both dogs and cats, dysmyelopoiesis, myelonecrosis, myelofibrosis, interstitial oedema, haemorrhage, acute inflammation and haemophagocytic syndrome were primarily noted in bone marrow specimens where there was evidence of erythroid hyperplasia. These animals were also more often neutropenic and thrombocytopenic, and had decreased 60 day survival when compared with dogs or cats with non-regenerative anaemia associated with erythroid maturation arrest or PRCA. Therefore, the pathogenesis of the non-regenerative anaemia in non-regenerative IMHA may involve both antibody-mediated destruction of bone marrow precursor cells and pathological events within the bone marrow that result in ineffective erythropoiesis.

  13. Clinical efficacy and safety of recombinant canine erythropoietin in dogs with anemia of chronic renal failure and dogs with recombinant human erythropoietin-induced red cell aplasia.

    Science.gov (United States)

    Randolph, John E; Scarlett, Janet; Stokol, Tracy; MacLeod, James N

    2004-01-01

    The efficacy and safety of recombinant canine erythropoietin (rcEPO) therapy was evaluated in 19 dogs with anemia of chronic renal failure (group 1) and 6 dogs with chronic renal failure and recombinant human erythropoietin (rhEPO)-induced red cell aplasia (group 2). Hematocrit (Hct) and absolute reticulocyte count (ARC) were monitored weekly for the first 8 weeks, CBC (including ARC) and serum iron profiles were evaluated monthly, and serum biochemical analyses were performed every 2 months for 6 (group 2) to 12 (group 1) months. For group 1 dogs, median Hct and ARC increased significantly during the 1st week of rcEPO treatment, and median Hct was sustained at >35% after week 5. In contrast, median Hct and ARC for group 2 did not change significantly with rcEPO treatment, even with doses greater than those used in group 1. Nevertheless, 2 (33%) of the 6 dogs in group 2 developed erythroid hyperplasia, reticulocytosis, and increases in Hct with rcEPO treatment. Although median systolic blood pressure did not change significantly in either group, 5 dogs developed systolic blood pressures > or = 180 mm Hg during the study. Appetite and energy level improved in most group 1 dogs with increases in Hct. Recombinant cEPO stimulated erythrocyte production in dogs with nonregenerative anemia secondary to chronic renal failure without causing the profound erythroid hypoplasia that can occur in rhEPO-treated dogs. Unfortunately, rcEPO was not as effective in restoring erythrocyte production in dogs that had previously developed rhEPO-induced red cell aplasia.

  14. S’auto évaluer pour agir : rôle du sentiment d’efficacité personnelle dans les pratiques d’enseignement

    Directory of Open Access Journals (Sweden)

    Sandra Safourcade

    2011-01-01

    Full Text Available Dans son quotidien, l’enseignant est amené à prendre des décisions, évaluer les éléments favorables du contexte, mobiliser des ressources afin d’organiser l’activité pédagogique. L’ensemble de ces choix tactiques ou stratégiques est sous-tendu par un processus d’auto-évaluation de son action que nous avons souhaité analyser. Au sein du collège les enseignants vivent en direct la nécessaire adaptation de leur projet pédagogique à la spécificité des élèves et à la différenciation de leurs actes. Ces enseignants, entre deux rives, ont au quotidien à la fois, à conduire leur activité, à auto évaluer celle-ci et à construire des pratiques efficaces. Notre recherche nous permet de décrire et d’expliquer le rôle des processus internes d’auto-évaluation des actions professionnelles. Ces procédures sont en interaction avec la construction chez l’enseignant d’un sentiment d’auto-efficacité qui, au-delà de renforcer l’estime de soi, est un véritable moteur de la valorisation et de la production des actes d’enseignement.In their day to day work, teachers are required to make decisions, evaluate the positive elements in their environment and mobilize resources in order to organize their pedagogical activity. All of these tactical or strategic choices are underlain by a self-evaluation process of their action that we have chosen to analyze. In junior high school, teachers get to see how it is necessary to adapt their pedagogical projects to students’ specificity and to differentiated acts. Daily, these teachers have, at the same time, to conduct their activity, to self-evaluate it and to conceive efficient practices. This study enables us to better describe and explain the role of internal self-assessment processes of professional actions. These self-evaluation processes interact with the building of a sense of efficiency that, beyond strengthening teachers’ self-esteem, is a true engine of

  15. Pyridoxal phosphate-responsive seizures in a patient with cerebral folate deficiency (CFD) and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM).

    Science.gov (United States)

    Dill, Patricia; Schneider, Jacques; Weber, Peter; Trachsel, Daniel; Tekin, Mustafa; Jakobs, Cornelis; Thöny, Beat; Blau, Nenad

    2011-11-01

    We present an 8-year-old boy with folate receptor alpha (FRα) defect and congenital deafness with labyrinthine aplasia, microtia and microdontia (LAMM syndrome). Both conditions are exceptionally rare autosomal recessive inherited diseases mapped to 11q13. Our patient was found to have novel homozygous nonsense mutations in the FOLR1 gene (p.R204X), and FGF3 gene (p.C50X). While the FRα defect is a disorder of brain-specific folate transport accompanied with cerebral folate deficiency (CFD) causing progressive neurological symptoms, LAMM syndrome is a solely malformative condition, with normal physical growth and cognitive development. Our patient presented with congenital deafness, hypotonia, dysphygia and ataxia in early childhood. At the age of 6 years he developed intractable epilepsy, and deteriorated clinically with respiratory arrest and severe hypercapnea at the age of 8 years. In contrast to the previously published patients with a FOLR1 gene defect, our patient presented with an abnormal l-dopa metabolism in CSF and high 3-O-methyl-dopa. Upon oral treatment with folinic acid the boy regained consciousness while the epilepsy could be successfully managed only with additional pyridoxal 5'-phosphate (PLP). This report pinpoints the importance of CSF folate investigations in children with unexplained progressive neurological presentations, even if a malformative syndrome is obviously present, and suggests a trial with PLP in folinic acid-unresponsive seizures.

  16. Rare birth defects associated with Morgagni hernia and segmental aplasia of uterine horn in bitch: Case reportDefeitos congênitos raros em cadela – relato de caso

    Directory of Open Access Journals (Sweden)

    Ricardo Santana de Lima

    2013-09-01

    Full Text Available Birth defects, deformities or abnormalities are terms used to describe developmental defects present at birth, most of which are rare in bitches. We report the case of a six-month old mongrel bitch corpse, which, when subjected to an anatomotopographic study revealed the presence of rare birth defects as Morgagni hernia and segmental aplasia of the right uterine horn with its attachment to the transverses muscle of abdominis. In association with HM, we observed the presence of dextrocardia and a defect of the abdominal wall supraumbilical characteristic of incompletely Pentalogy of Cantrell’s, syndrome so far described only in humans. In association with segmental aplasia of the uterine horn, we observed the ipsilateral presence of the renal hypoplasia and ureteral agenesis. The diagnosis of those abnormalities was based on anatomical findings and confirmed histologically. Despite the rarity and complexity of the abnormalities first described in bitches, the literature suggested that the prognosis may be favorable to the life of the animal. However, early diagnosis is essential to avoid the potential complications of those diseasesDefeitos congênitos, deformidades ou anormalidades são termos usados para descrever defeitos no desenvolvimento presentes ao nascimento. A maioria destes, como a aplasia segmentar uterina, é de ocorrência rara em cadelas. Relata-se o caso de um cadáver de cadela, sem raça definida, de seis meses de idade, que ao ser submetido ao estudo anatomotopográfico revelou a presença de aplasia segmentar uterina (ASU associada à hérnia de Morgagni (HM, agenesia ureteral (AU e hipoplasia renal direita (HR. Além destas anormalidades, foi observada a presença de dextrocardia e de um defeito da parede abdominal supraumbilical, que caracterizam a forma incompleta da pentalogia de Cantrell, só descrita em humanos. O diagnóstico destas anormalidades foi baseado nos achados anatômicos e confirmado histologicamente. A

  17. Hematopoiesis stimulation test by interleukin 1{alpha} gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation; Essais de stimulation de l'hematopoiese par le transfert de gene de l'interleukine-1{alpha} chez le macaque cynomolgus: application a l'aplasie medullaire secondaire a une irradiation accidentelle

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, Th.

    2002-12-15

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  18. Rechallenge with intravenous recombinant human erythropoietin can be successful following the treatment of anti-recombinant erythropoietin associated pure red cell aplasia.

    Science.gov (United States)

    Praditpornsilpa, Kearkiat; Tiranathanakul, Khajohn; Jootar, Saengsuree; Tungsanga, Kriang; Eiam-Ong, Somchai

    2014-05-01

    Anti recombinant human erythropoietin (r-HuEpo) associated pure red cell aplasia (PRCA) is an immunologic adverse effect of using subcutaneous r-HuEpo. Immunosuppressive agents have been suggested as treatment of this serious complication. After the reversal of anti-r-HuEpo antibody, the patients continue to have renal anemia and require long-term blood transfusion, albeit less frequently than when the antibody is positive. It is controversial whether re-challenging the patients with r-HuEpo is appropriate because re-challenging may cause the reappearance of the antibody. To balance the risk of antir-HuEpo antibody reappearance and longterm blood transfusion complications, we re-challenged r-HuEpo in five anti-r-HuEpo associated PRCA cases after a successful reversal of antibody using prednisolone in combination with cyclophosphamide. The rechallenge was performed intravenously since there were no reports of anti-r-HuEpo associated PRCA cases using this administration route. The duration after the reversal of antibody was 2.4 months before the re-challenge. Two patients were immediately re-challenged as soon as the antibodies reversed. After rechallenge with intravenous r-HuEpo, all patients responded to r-HuEpo: target level of Hb was maintained, blood transfusion was not required, and anti-r-HuEpo was consistently negative. All patients were followed for at least 6 months after re-challenge. Our data suggest that re-challenge with intravenous r-HuEpo can successfully treat anti- r-HuEpo associated PRCA.

  19. Very Long Segment Congenital Thoracoabdominal Aortic Coarctation (Diffuse Aortic Dysplasia) with Infrarenal Aortobi-Iliac and Cavobi-Iliac Aplasia in a 30-Year-Old Patient.

    Science.gov (United States)

    Mamopoulos, Apostolos; Luther, Bernd

    2015-10-01

    Congenital dysplastic aortic syndromes range from coarctation at the aortic isthmus to more extended aortic disease (midaortic syndrome). The latter is usually restricted to dysplastic aortic segments of up to 15 cm. Long segment dysplasia of the entire abdominal or thoracic aorta is extremely rare. This case of a 30-year-old patient with a very long segment congenital thoracoabdominal aortic coarctation and infrarenal aortobi-iliac and cavobi-iliac aplasia represents to our knowledge the most extended congenital vascular malformation in a surviving adult patient. The developed extensive collateral pathways ensured the survival of the patient, so that the main clinical manifestation was a refractory hypertension. Because of the extent of the disease, open surgery represented the only viable option. Interestingly, after 30 years of uncontrollable hypertension, the patient's blood pressure promptly responded to surgical treatment. A concomitant infrarenal aplasia of both the aorta and cava vein is also very unusual and points to a major developmental deficit during vascular embryogenesis.

  20. Étude préliminaire des pratiques de navigation dans un environnement d’apprentissage informatique et mesure de leur efficacité pédagogique

    Directory of Open Access Journals (Sweden)

    Gilles Lavigne

    2008-01-01

    Full Text Available Inscrite dans une expérience plus vaste centrée sur l’à-propos d’introduire des objets d’apprentissage dans la formation en statistique des étudiants de premier cycle, cette recherche vise plus précisément à étudier l’usage effectif des ressources accessibles dans un environnement informatisé d’apprentissage. L’analyse met en jeu le registre des logs fournis par la plateforme Moodle. Les résultats montrent que l’analyse de la navigation recèle une information à portée pédagogique intéressante, relative à la définition de stratégies d’apprentissage en ligne et à la mesure de l’efficacité pédagogique de ces dernières. Il semble exister, en effet, une relation entre l’intensité d’utilisation des ressources en ligne et la note obtenue à la fin de la formation.

  1. Élaboration et validation de l’échelle de la perception et du sentiment d’auto-efficacité en vidéocommunication (ÉPAV .

    Directory of Open Access Journals (Sweden)

    Patrick Giroux

    2008-01-01

    Full Text Available L’article présente le processus d’élaboration et de validation de l’échelle de la perception et du sentiment d’auto-efficacité des apprenants vis-à-vis de la vidéocommunication (ÉPAV. Basée sur la théorie sociocognitive de Bandura (1977, 1982, 1997/2007, cette échelle permet d’évaluer deux dimensions: la perception générale de la vidéocommunication et celle que l’individu a de son propre niveau de compétence dans ce contexte. Les résultats soutiennent la structure bidimensionnelle ainsi que la cohérence interne de l’ÉPAV. Des corrélations avec des mesures de la motivation et de l’expérience en vidéocommunication ainsi qu’avec des mesures de l’attention en appuient la validité.

  2. Effect of ionizing radiation on hematopoietic stem cells and progenitor cells: Role of apoptosis and potential therapeutic significance of anti-apoptotic treatments; Effet des rayonnements ionisants sur les cellules souches et progeniteurs hematopoietiques : place de l'apoptose et interet therapeutique potentiel des traitements antiapoptotiques

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mourcin, F.; Grenier, N.; Mayol, J.F.; Leroux, V. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France); Sotto, J.J. [Inst. Albert Bonniot, La Tronche (France); Herodin, F. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    Bone marrow aplasia observed following ionizing radiation exposure (Total Body Irradiation; gamma dose range: 2-10 Gy) is a result, in particular, of the radiation-induced (RI) apoptosis in hematopoietic stem and progenitor cells (HSPC). We have previously shown in a baboon model of mobilized peripheral blood CD34{sup +} cell irradiation in vitro that RI apoptosis in HSPC was an early event, mostly occurring within the first 24 hours, which involves the CD95 Fas pathway. Apoptosis may be significantly reduced with a combination of 4 cytokines (4F): Stem Cell Factor (SCF), FLT-3 Ligand (FL), thrombopoietin (TPO), and interleukin-3 (IL-3), each at 50 ng{center_dot}mL{sup -1} (15% survival versus <3% untreated cells, 24 h post-irradiation at 2.5 Gy). In this study we show that addition of TNF-{alpha}(800 IU/ml) induces an increase in 4F efficacy in terms of cell survival 24 h after incubation (26% survival after 24 h irradiation exposure at 2.5 Gy) and amplification (k) of CD34{sup +} cells after 6 days in a serum free culture medium (SFM) (k{sub CD34{sup +}} = 4.3 and 6.3 respectively for 4F and successive 4F + TNF-{alpha}/4F treatments). In addition, the 4F combination allows culture on pre-established allogenic irradiated stromal cells in vitro at 4 Gy (k{sub CD34{sup +}} = 4.5). Overall this study suggests (i) the potential therapeutic interest for an early administration of anti-apoptotic cytokines with or without hematopoiesis inhibitors (emergency cytokine therapy) and (ii) the feasibility in the accidentally irradiated individual, of autologous cell therapy based on ex vivo expansion in order to perform autograft of residual HSPC collected after the accident. (author)

  3. Le Sentiment d’Efficacité Professionnelle, un indicateur pour connaître le développement professionnel des « nouveaux » professeurs de l’enseignement agricole français

    Directory of Open Access Journals (Sweden)

    Jean-François Marcel

    2011-06-01

    Full Text Available Cet article est structuré autour d’un indicateur visant à appréhender le développement professionnel dans une perspective heuristique. Il s’agit du Sentiment d’Efficacité Professionnelle emprunté à Bandura (2003. Cet indicateur se positionne le long d’un continuum allant de la théorie à l’empirie et en assume la cohérence et la consistance. Ainsi, il s’ancre dans un cadre théorique (le développement professionnel perçu et, au travers d’un dispositif méthodologique, permet d’accéder à l’empirie. L’enquête par questionnaire est conduite auprès d’une population de nouveaux professeurs de l’enseignement agricole français. Elle permet de mettre au jour un panorama du développement professionnel perçu par ces enseignants, d’alimenter une analyse critique de l’indicateur proposé et de dresser quelques perspectives pour les recherches à venir.The article is based on an indicator aiming at understanding teachers’ professional development in a heuristic perspective: professional self efficacy borrowed from Bandura (2003. This indicator is situated in a continuum going from theory to empirical data and maintains both its consistency and substance. It is thus, part of a theoretical framework (perceived professional development and permits, through a methodological process, to reach empirical elements. A survey by questionnaire was carried out among new teachers of French agricultural education. The study brings to light an overview of the professional development perceived by these teachers, it permits to build a critical analysis of the indicator in question and draw up new prospects for future research.

  4. One-Dimensional Modelling of Polymer Flood Performance. Analytical and Graphical Solutions Modélisation de l'efficacité du déplacement unidimensionnel par injection de polymères. Solutions analytiques et graphiques

    Directory of Open Access Journals (Sweden)

    Grattoni C. A.

    2006-11-01

    Full Text Available A graphical method for simulating linear polymer flooding is proposed. The method is based upon the analytical solution of Darcy's law and continuity equation which describe the two-phase, one-dimensional, incompressible flow of oil and polymer solution through the reservoir rock. Continuous polymer injection and polymer slug injection are considered. Several physical mechanisms determining microscopic displacement efficiency are taken into account: resistance factor, residual resistance factor, retention composed by adsorption and mechanical entrapment, and inaccessible pore volume. Other properties are not considered: mixing and dispersion, shear and thermal degradation. This analytical-graphical model closely reproduces linear laboratory oil displacement experiments. Consequently, it can be used by the Field Engineer to rapidly estimate the additional oil recoverable by a linear polymer flood. On propose dans cet article une méthode graphique de simulation de l'injection de polymères dans le cas unidimensionnel. Cette méthode est basée sur la solution analytique de la loi de Darcy et de l'équation de continuité qui décrivent l'écoulement diphasique incompressible unidimen-sionnel d'huile et d'une solution de polymères à travers la roche réservoir. On examine l'injection continue et l'injection de bouchons de polymères. On prend en compte plusieurs mécanismes physiques qui déterminent l'efficacité du déplacement microscopique : facteur de ré-sistance, facteur de résistance résiduel, rétention due à l'adsorption et au piégeage mécanique et, enfin, volume des pores inacessibles. On ne tient pas compte des autres propriétés : mélange et dispersion, dégradation mécanique et thermique. Ce modèle analytique et graphique reproduit très directement les expériences de laboratoire de déplacement d'huile en milieu unidimensionnel. II peut donc être utilisé par l'ingénieur de chantier pour une estimation rapide de l

  5. Efficacité du renforcement des poutres en béton armé par des matériaux composites Efficiency of strengthening concrete beams using FRP

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    Chemrouk M

    2012-09-01

    Full Text Available Pour réduire le coût et assurer un comportement relativement plus ductile pour des éléments en béton armés renforcés, l’addition des fibres de verre pourrait être considérée comme solution de rechange, puisqu’elles sont relativement plus déformables et meilleur marché que la fibre de carbone. Dans ce sens, le travail actuel vise à évaluer l’efficacité du renfort externe sur les poutres renforcées par le tissu de FRP (verre-carbone. Un total de sept poutres en béton armé a été renforcé en flexion et en cisaillement, et testé sous un chargement quatre points cyclique statique. Les champs des contraintes et de déformation ont été contrôlés par un système de caméra numérique “Gom-Aramis”. Les résultats ont été analysés en termes de résistance, rigidité, ductilité et mode de rupture. To reduce the cost and to ensure a behavior relatively more ductile for concrete strengthening elements, the addition of glass fibers could be regarded as solution of replacement, since they are relatively more deformable and cheaper than carbon fiber. In this sense, current work aims at evaluating the effectiveness of the external reinforcement on the beams strengthened by fabric of FRP (glass – carbon. Seven concrete beams reinforced were strengthening in bending and shearing, and were testing under four point cyclic static. The fields of the stresses and deformation were controlled by a numerical system of camera “Gom-Aramis”. The results were analyzing in term of resistance, rigidity, ductility and mode of failure

  6. Relative biological efficiency of 592 MeV protons. Analysis of the biological effect of secondary radiation; Efficacite biologique relative des protons de 592 MeV. Analyse de l'effet biologique du aux rayonnements secondaires

    Energy Technology Data Exchange (ETDEWEB)

    Legeay, G.; Baarli, J. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires; European Organization for Nuclear Research, Geneva (Switzerland)

    1968-07-01

    The relative biological efficiency (RBE) of high energy protons is of importance because of their effects in the field of radioprotection around large accelerators and during space-flights. The nature of the interactions between 592 MeV protons and biological tissues makes it necessary to take into consideration the contribution of secondary radiation to the biological effect. Since it is not possible to obtain from a synchrotron a beam having a sufficiently large cross-section to irradiate large animals, one has to resort to certain devices concerning the mode of exposure when small laboratory animals are used. By irradiating rats individually and in groups, and by using the lethal test as a function of time, the authors show that the value of the RBE is different for animals of the same species having the same biological parameters. Thus there appears an increase in the biological effect due to secondary radiation produced in nuclear cascades which develop in a large volume, for example that of a human being. (author) [French] L'efficacite biologique relative des protons de haute energie doit etre etudiee en raison de leur incidence sur la radioprotection autour des grands accelerateurs et lors des vols spatiaux. La nature des interactions des protons de 592 MeV avec les tissus biologiques rend necessaire d'envisager la contribution des rayonnements secondaires a l'effet biologique. Ne pouvant obtenir aupres d'un synchrotron un faisceau de section importante pour irradier de gros animaux, il est necessaire de faire appel a des artifices portant sur le mode d'exposition lorsque l'on utilise les petits animaux de laboratoire. En irradiant des rats individuellement et en groupe et en utilisant le test de letalite en fonction du temps, les auteurs montrent que la valeur de l'EBR est differente sur des animaux de la meme espece presentant les memes parametres biologiques. Il apparait ainsi un accroissement de l'effet biologique

  7. Aspergillosis in immunocompromised children acute myeloid leukemia and bone marrow aplasia.: Report of two cases Aspergilose em crianças imunocomprometidas com leucemia mielóide aguda e aplasta de medula óssea: Registro de 2 casos

    Directory of Open Access Journals (Sweden)

    Maria Zilda de Aquino

    1994-10-01

    Full Text Available Two cases of Aspergillosis in immunocompromised children are reported. Both were caused by Aspergillns flavus. Early diagnosis and treatment led to the remission of the process. One patient had acute myeloid leukemia; the fungus was isolated from the blood. The other patient with bone marrow aplasia, presented an invasive aspergillosis of the paranasal sinuses with dissemination of fungal infection; the diagnosis was obtained by histology and culture of biopsied tissue from a palatal ulceration.No presente trabalho são registrados dois casos de aspergilose em crianças imunocomprometidas. O estudo micológico completo identificou Aspergillus flavus como agente dos dois processos. A presença cada vez mais frequente da aspergilose invasiva deve-se ao número crescente de pacientes imunocomprometidos, muitos com hemopatias graves submetidos à quimioterapia. O diagnóstico precoce em um dos casos possibilitou remissão do processo. Tratava-se de paciente com leucemia mielóide aguda, tendo sido isolado o fungo do sangue circulante. O segundo caso evoluiu para óbito, com infecção fúngica generalizada.

  8. B lymphocyte differentiation in lethally irradiated and reconstituted mice. I. The effect of strontium-89 induced bone marrow aplasia on the recovery of the B cell compartment in the spleen

    Energy Technology Data Exchange (ETDEWEB)

    Rozing, J.; Buurman, W.A.; Benner, R.

    1976-06-01

    The influence of /sup 89/Sr-treatment on the recovery of the B cell compartment in lethally irradiated, fetal liver reconstituted mice was studied by means of membrane fluorescence, /sup 89/Sr is a bone-seeking radio-isotope which causes in a dose of 3 ..mu..Ci /sup 89/Sr/g body weight a depletion of all nucleated cells, including immunoglobulin-bearing (B) cells, of the bone marrow. Treatment of irradiated and fetal liver reconstituted mice with 3 ..mu..Ci /sup 89/Sr/g body weight immediately and at 17 days after irradiation and reconstitution prevented recovery of the nucleated cell population, including B cells, in the bone marrow. In the spleen of such mice both nucleated cells and B cells reappeared at day 7 and 14 respectively. The B cell population in the spleen did not recover up to normal values during the experimental period of 45 days. It is concluded that B cell differentiation in lethally irradiated, fetal liver reconstituted mice can take place outside the bone marrow. The efficiency of this extra-medullary differentiation is discussed. The conclusion was drawn that mice with a /sup 89/Sr-induced bone marrow aplasia are able to generate B lymphocytes. Consequently the bone marrow microenvironment seems not to be obligate to the differentiation of B lymphocytes. The peripheral lymphoid organs of such mice were found to be unable to compensate completely for the absence of B lymphocyte production in the bone marrow.

  9. A case of recurrent autoimmune hemolytic anemia during remission associated with acute pure red cell aplasia and hemophagocytic syndrome due to human parvovirus B19 infection successfully treated by steroid pulse therapy with a review of the literature.

    Science.gov (United States)

    Sekiguchi, Yasunobu; Shimada, Asami; Imai, Hidenori; Wakabayashi, Mutsumi; Sugimoto, Keiji; Nakamura, Noriko; Sawada, Tomohiro; Komatsu, Norio; Noguchi, Masaaki

    2014-01-01

    The patient was a 47-year-old man diagnosed as having autoimmune hemolytic anemia (AIHA) in April 2011. He also had a congenital chromosomal abnormality, a balanced translocation. Treatment with prednisolone (PSL) 60 mg/day resulted in resolution of the AIHA, and the treatment was completed in November 2011. While the patient no longer had anemia, the direct and indirect Coombs tests remained positive. In May 2013, he developed recurrent AIHA associated with acute pure red cell aplasia (PRCA) and hemophagocytic syndrome (HPS) caused by human parvovirus B19 (HPV B19) infection. Tests for anti-erythropoietin and anti-erythropoietin receptor antibodies were positive. Steroid pulse therapy resulted in resolution of the AIHA, PRCA, as well as HPS. The serum test for anti-erythropoietin antibodies also became negative after the treatment. However, although the serum was positive for anti-HPV B19 IgG antibodies, the patient continued to have a low CD4 lymphocyte count (CD4, <300/μL) and persistent HPV B19 infection (HPV B19 DNA remained positive), suggesting the risk of recurrence and bone marrow failure.

  10. Etude longitudinale rétrospective sur l'efficacité externe et l'équité d'accomplissement des diplômés sénégalais de l'ENSETP de 1981 à 1994

    OpenAIRE

    Fadiga, Maïmouna

    2003-01-01

    La présente recherche est une étude portant sur l'évaluation de l'efficacité externe et de l'équité d'accomplissement des diplômés sénégalais sortis de l'Ecole Normale Supérieure d'Enseignement Technique et Professionnel (ENSETP) de 1981 à 1994. Malgré de nombreux dysfonctionnements notés au niveau des systèmes éducatifs de la plupart des pays d'Afrique subsaharienne, l'enseignement technique et la formation professionnelle semblaient y constituer des voies de salut dans la dynamique de le...

  11. Influence de l'énergie de surface d'un tambour deshuileur sur son efficacité de relevage Influence of the Surface Energy of a Deoiling Drum on Its Gathering Efficiency

    Directory of Open Access Journals (Sweden)

    Aurelle Y.

    2006-11-01

    Full Text Available Au cours de cette étude est analysée l'influence de l'énergie de surface d'un tambour déshuileur sur son efficacité et sa sélectivité de relevage. Quatre tambours en acier inoxydable, en polychlorure de vinyle, en polypropylène et en dérivé fluorocarboné de tensions critiques de mouillage différentes sont testés comparativement en fonction de l'histoire de leur expositionvis-à-vis de phases hydrocarbure (kérosène et eau. Les essais réalisés montrent que seuls les tambours en dérivé fluorocarboné de très faible tension critique de mouillage s'avèrent intéressants pour des utilisations industrielles. En effet, ils présentent un comportement indépendant de l'histoire de leur exposition ce qui les rend très faciles à utiliser, sans précautions particulières, du fait de leur très grande sélectivité vis-à-vis des hydrocarbures. Par contre, les autres tambours, qui présentent des contributions polaires non négligeables à leur énergie de surface, ont des comportements vis-à-vis des hydrocarbures fonction de l'histoire de leur exposition et ne s'avèrent pas sélectifs vis-à-vis des hydrocarbures à récupérer. The aim of this article is to analyze the influence of the surface energy of a deoiling drum on its gathering efficiency and selectivity. The project consists in testing drums having the same size but made of materials having different surface energies so as to evaluate the influence of this key parameter that had previously been poorly analyzed. Four materials were chosen : stainless steel, polyvinyl chloride, polypropylene, and a fluorocarbon derivative. These materials are representative, a priori, of the behavior of most materials because of the position of their critical wetting tension (gamma c compared to the superficial tension values of water (72 dyn/cm and the hydrocarbon phases to be gathered (25 to 35 dyn/cm (Fig. 1. It should be noted that the fluorocarbon derivative drum tested was patented by

  12. Clinical importance of digitized chest X-ray for detection of pulmonary infiltrations in bone marrow transplant patients during aplasia; Wertigkeit der digitalen Thoraxaufnahme bei der Detektion von Lungeninfiltraten knochenmarktransplantierten Patienten in der Aplasie

    Energy Technology Data Exchange (ETDEWEB)

    Weber, C.; Maas, R.; Steiner, P.; Kramer, J.; Bumann, D.; Buecheler, E. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Abt. fuer Roentgendiagnostik; Zander, A.R. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Zentrum fuer Knochenmarktransplantation

    1999-10-01

    Purpose: Evaluation of digitized chest X-ray for the detection of pulmonary infiltrations in bone marrow transplant patients during aplasia. Methods: Digitized chest X-rays of 40 patients (21 female, 19 male) with 'Fever of unknown origin' (FUO) were evaluated concerning radiological signs of pulmonary infiltrations and correlated to clinical findings, blood chemistry, microbiology and bronchoscopy. Additionally, an individual risk profile was established. Results: In 11/40 patients pulmonary infiltrations were detected in digitized chest X-rays (group 1). 10/11 developed an infectious pulmonary infiltration. 29/40 patients developed no pulmonary infiltration (group 2). When fever increased for the first time (initial chest X-ray) a sensitivity, specificity, positive and negative predictive value of 46%, 86%, 56%, 81% and for the chest X-rays in process of 61%, 79%, 68% and 73% was found. C-reactive protein and temperature increase occured statistically significantly earlier (p<0.05) in group 1 compared to group 2. The average latency of digital chest X-rays in comparison to c-reactive protein and temperature increase was 6 days. The incidence of risk factors was significantly higher in group 1 in comparison to group 2 (p<0.05). Conclusion: Digitized chest X-rays are not a reliable method for primary detection of pulmonary infiltrations after bone marrow transplantation. Individual risk factors have to be taken into consideration to indicate further diagnostic methods such as computed tomography at an earlier time. (orig.) [German] Ziel: Wertigkeit der digitalen Thoraxaufnahme bei der Detektion pulmonaler Infiltrate bei knochenmarktransplantierten Patienten in der Aplasie. Methoden: Digitale Thoraxaufnahmen von 40 Patienten (21 Frauen, 19 Maenner) in Aplasie mit Fieber unklarer Genese wurden nach Zeichen pulmonaler Infiltrate ausgewertet und mit klinischen, laborchemischen, mikrobiologischen und bronchoskopischen Befunden korreliert. Zusaetzlich wurde ein

  13. Featares of T-cell large granular lymphocytic leukemia with pure red cell aplasia%T大颗粒淋巴细胞白血病伴纯红细胞再生障碍特征与治疗

    Institute of Scientific and Technical Information of China (English)

    王建宁; 傅行财; 孟庆奇; 宋敏; 候艳秋; 张柳波; 包红雨

    2013-01-01

    Objective:To explore the clinical features and treatment of T-cell large granular lymphocytic leukemia(T-LGLL) associated with pure red cell aplasia(PRCA).Methods:Two cases of T-LGLL with PRCA were reported and the related articles were reviewed.Results:Two elder female patients had indolent process,mainly presenting with anemia.Clinic examination showed no lymphadenopathy and hepatosplenomegaly.The patients had no recurrent infections and rheumatoid arthritis.Peripheral blood smear showed predominance of mature lymphocytic cells,with most showing characteristic large granular lymphocytic morphology.Flowcytometric immunophenotypic analyses were done and peripheral lymphocytes showed abnormal immunophenotypes which were compatible with T-LGLL.Clonality could be proven on detecting gene rearrangement of T-cell recepter γchain.Bone marrow aspirate smears showed markedly decreased erythroid series.Conclusion:T-LGLL is a rare disease.The clinic characteristics of Asian patients were markedly different from Western patients.Especially,Asian patients had more anemia attributing to a high incidence of PRCA.The findings suggested that T-LGLL with PRCA may be prognostic of a good response to immunosuppression.%目的:探讨T-大颗粒淋巴细胞白血病(T-LGLL)伴纯红细胞再生障碍(PRCA)的临床特征与治疗.方法:报告2例T-LGLL合并PRCA并结合文献进行复习.结果:患者为老年女性,临床进展缓慢,主要表现为贫血,无淋巴结和肝脾肿大,无反复感染和类风湿性关节炎表现,血涂片以大颗粒淋巴细胞为主,免疫分型符合T-LGLL,TCRγ基因重排阳性,骨髓红系细胞明显减少.结论:T-LGLL为少见疾病,亚洲患者临床特征与西方患者有明显差异,尤其是合并PRCA的发生率高,对免疫抑制剂治疗反应良好.

  14. Avaliação hematológica dos pacientes diagnosticados com aplasia medular do ambulatório de hematologia e hemoterapia do Conjunto Hospitalar de Sorocaba (CHS

    Directory of Open Access Journals (Sweden)

    Ivan Fernandes Filho

    2014-10-01

    Full Text Available Introdução: Aplasia Medular (AM é um distúrbio de produção de células hematopoiéticas decorrentes da perda de tecido medular caracterizado clinicamente por astenia, petéquias, dispneia, equimoses, cefaleia e hemorragias. Objetivos: avaliar os prontuários dos pacientes com AM através da investigação do perfil clínico de cada paciente, as possíveis etiologias da doença, tratamentos realizados e sua evolução. Métodos: analisamos os prontuários de 11 pacientes diagnosticados com AM no momento do diagnóstico e da última consulta, recolhendo informações quanto à etiologia, aos achados laboratoriais e à evolução dos pacientes em cada tratamento. Resultados: A proporção entre homens e mulheres era 63/77. A idade média foi de 31,36 anos. Houve VCM (Máximo=122,64 fL; Mínimo=80,5 fL, Ht (Máximo=31%; Mínimo=6%, leucócitos (Máximo= 7640/μL; Mínimo=800/μL, segmentados (Máximo=3590/μL; Mínimo=161/μL, média de 72401,8 plaquetas/mm3 e mediana de 16000 plaquetas /mm3. 45% dos pacientes foram submetidos ao transplante de medula óssea, sendo que todos se encontram, no momento, vivos e sem a doença. No tratamento com ciclosporina A 300mg+Prednisona 80mg (20% dos pacientes, 50% dos pacientes estão vivos e sem a doença. Conclusão: As etiologias e classificação da doença mostraram que a maioria dos pacientes apresentou AM idiopática em sua forma grave com evolução hematológica satisfatória durante o tratamento.

  15. Collection efficiency of charges in ionization chambers in presence of constant or variable radiation intensity; Efficacite de la collection des charges dans les chambres d'ionisation en presence d'une intensite de rayonnement ionisant constante ou variable

    Energy Technology Data Exchange (ETDEWEB)

    Decuyper, J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1970-07-01

    The theoretical and experimental study of the collection of carriers built up by ionization in standard chambers, is made by varying the value of different acting parameters. In the presence of constant ionization intensity and under a D.C. and A.C. voltage, the effect of geometry, recombination, diffusion and attachment is analyzed. The compensation of thermal neutron D.C. chambers is equally considered. Under a time dependent ionization intensity and D.C. voltage, is then studied the effect of recombination on current response, and on the collection efficiency of all formed charges. (author) [French] L'etude theorique et experimentale de la collection des porteurs crees par ionisation dans les chambres couramment utilisees est entreprise en fonction de la valeur des differents parametres agissants. En presence d'une ionisation constante et sous une tension d'alimentation d'abord continue puis alternative, on analyse l'influence de la geometrie, de la recombinaison, de la diffusion et de l'attachement. La compensation des chambres a courant continu de mesure neutronique est egalement examinee. Ensuite, sous une intensite d'ionisation variable dans le temps et en alimentation continue, on etudie l'effet de la recombinaison sur la reponse en courant et sur l'efficacite de la collection de la charge totale liberee. (auteur)

  16. Efficacité de la prévention de la transmission mère-enfant du Virus de l'Immunodéficience Humaine par le protocole 2010 de l'Organisation Mondiale de la Santé au Centre Médical Saint Camille de Ouagadougou (Burkina Faso)

    Science.gov (United States)

    OuédraogoYugbaré, Solange Odile; Zagré, Nikaise; Koueta, Fla; Dao, Lassina; Kam, Ludovic; Ouattara, Diarra Yé; Simporé, Jacques

    2015-01-01

    L’épidémie du Virus de l'Immunodéficience Humaine en milieu pédiatrique est surtout le résultat de la transmission mère-enfant. Notre étude a pour objectif de décrire l'efficacité de la prévention de la transmission mère-enfant du Virus de l'Immunodéficience Humaine par le protocole OMS 2010 (Option A et trithérapie) au centre médical saint Camille de Ouagadougou. Nous avons mené une étude d'une cohorte d'enfants suivis dans le cadre de la prévention de la transmission mère-enfant du Virus de l'Immunodéficience Humaine au centre médical saint Camille de Ouagadougou sur une période de 2 ans allant du 1er Janvier 2012 au 31 Décembre 2013. Nous avons obtenu l'accord de 4900 femmes enceintes pour le dépistage de l'infection du Virus de l'Immunodéficience Humaine et 238 gestantes ont été diagnostiquées séropositives soit 4,86% de séroprévalence. Les femmes étaient surtout infectées par le Virus de l'Immunodéficience Humaine avec de type I (95,38%)). La majorité était sous trithérapie (74,3%) et (25,7%) sous prophylaxie (option A). Les nouveau-nés (92,5%) ont reçu un traitement antirétroviral à base de névirapine dans les 72 heures après la naissance. L'allaitement sécurisé a été appliquée dans 78% des cas. Le taux global de transmission mère-enfant du VIH était de 3,6% avec 3% de transmission chez les enfants nés de mères sous trithérapie antirétrovirale et 6,3% dans les cas de prophylaxie antirétrovirale. Le facteur de risque de transmission a été le long délai du début d'administration des antirétroviraux chez le nouveau-né. La mortalité infantile à un an était de 3,5%. Cette étude a révélé l'efficacité de l'Option A et conforté celle de la trithérapie, le passage à l'Option B+ serait donc plus bénéfique. PMID:26966499

  17. Evaluation of the Energy Efficiency of a Fleet of Electric Vehicle for Eco-Driving Application Évaluation de l’efficacité énergétique d’une flotte de véhicules électriques dédiée à une application d’éco-conduite

    Directory of Open Access Journals (Sweden)

    Dib W.

    2012-09-01

    Full Text Available In this paper, an approach to evaluate the energy efficiency of an electrical vehicle during a short trip is addressed. This approach provides metrics that can be used to evaluate the potential of improvement achievable via intelligent eco-driving techniques and the performance actually achieved by any of them. It can be the basis for an evaluation of a fleet of vehicles and of a whole city for which an energy efficiency map could be derived, depending for instance of traffic management strategy. Experimental data are provided to illustrate the approach for a fleet of electric vehicles in an urban environment. The methods proposed are intended to be the basis of a driver assistance system oriented to optimal eco-driving. Dans cet article, nous proposons une approche pour évaluer l’efficacité énergétique d’un véhicule électrique lors d’un déplacement urbain. Cette approche fournit des outils permettant d’évaluer le gain énergétique réalisable par l’intermédiaire des techniques intelligentes d’éco-conduite. Cette approche peut être utilisée pour évaluer une flotte de véhicules, ainsi que pour élaborer une cartographie énergétique d’une ville. Des données expérimentales sont fournies pour illustrer cette approche sur une flotte de véhicules électriques dans un environnement urbain. Les méthodes d’éco-conduite proposées sont destinées à constituer la base d’un système d’assistance au conducteur.

  18. Highly Relevant Mentoring (HRM as a Faculty Development Model for Web-Based Instruction / Highly Relevant Mentoring (HRM (mentorat haute efficacité, un modèle de formation du corps professoral à l’enseignement en réseau

    Directory of Open Access Journals (Sweden)

    Lorraine Carter

    2012-02-01

    Full Text Available This paper describes a faculty development model called the highly relevant mentoring (HRM model; the model includes a framework as well as some practical strategies for meeting the professional development needs of faculty who teach web-based courses. The paper further emphasizes the need for faculty and administrative buy-in for HRM and examines relevant theories that may be used to guide HRM in web-based teaching environments. Of note is that HRM was conceived by the instructional design staff who contributed to this paper before the concept of high impact mentoring appeared in the recent literature (2009. While the model is appropriate in various disciplines and professions, the examples and scenarios provided are drawn from a Canadian university’s experience of using HRM, in conjunction with a pedagogical approach called ICARE, in a variety of nursing courses and programs. Cet article décrit un modèle de formation du personnel enseignant intitulé « highly relevant mentoring (HRM » (mentorat haute efficacité; ce modèle comprend une structure et des stratégies pratiques visant à combler les besoins en formation du corps professoral d’une faculté offrant des cours en réseau. L’article souligne la nécessité d’un appui facultaire et administratif au HRM et étudie les théories pertinentes pouvant servir à guider le HRM dans des milieux d’enseignement en réseau. On notera que le HRM a été conçu par l’équipe de conception de matériel pédagogique qui a contribué à cet article avant l’apparition, dans les publications récentes (2009, du concept de « high impact mentoring » (mentorat à haut rendement. Bien que ce dernier modèle convienne à diverses disciplines et professions, les exemples et les scénarios fournis ici sont tirés de l’expérience d’utilisation du HRM dans une université canadienne, conjointement à une approche pédagogique appelée ICARE, dans une variété de cours et de programmes

  19. Variabilité selon le captureur de l'efficacité de répulsifs à base d'huiles végétales dans la protection individuelle contre les piqûres de Simulium damnosum s. l.

    Directory of Open Access Journals (Sweden)

    Sylla M.

    2002-12-01

    Full Text Available Dans le présent article, nous faisons état de la variabilité selon le captureur de l'efficacité de répulsifs à base d'huiles végétales appliquées sur la peau contre les piqûres de Simulium damnosum s. l. Les expérimentations ont été effectuées en zones de savane (Chaussée-Niaka et de forêt (Soubré de Côte d'Ivoire. Les formulations (lotions, crèmes] testées lors de ces travaux ont été obtenues à partir d'huiles d'amande de palme (Elaeis guineensis, de coco (Cocos nucifera et de gobi (Carapa procera. La technique classique de capture sur homme à l'aide de tubes à hémolyse en matière plastique a été utilisée. Pour chaque journée d'expérimentation, un captureur non traité (jambes non enduites de répulsif servait de témoin. Les résultats indiquent qu'en savane, quels que soient le répulsif et le captureur, la densité simulidienne se situait de 1 à 4, 1 à 6 et de 2 à 10 simulies par homme et par jour lorsque le captureur était respectivement protégé avec le coco, le palmiste et le gobi. Avec les mêmes répulsifs, en zone de forêt, l'agressivité simulidienne variait de 9 à 16, de 2 à 30 et de 8 à 49 piqûres par jour. En comparaison, le témoin recevait de 67 à 90 et de 310 à 533 piqûres par jour, respectivement en zones de savane et de forêt. Malgré les variations importantes dans le nombre de simulies capturées en fonction du captureur choisi, nos résultats montrent que quels que soient le répulsif et l'espèce simulidienne, une protection similaire est conférée à tous les captureurs. Ils indiquent également que le recours à des substances naturelles locales, utilisées comme répulsifs en application dermique, est l'une des meilleures méthodes de protection personnelle contre les simulies.

  20. Therapeutic management of locally unresectable pancreatic cancer; Adenocarcinomes du pancreas localement evolues: modalites therapeutiques actuelles

    Energy Technology Data Exchange (ETDEWEB)

    Lombard-Bohas, C.; Saurin, J.C. [Centre Hospitalier Universitaire Edouard-Herriot, 69 - Lyon (France); Mornex, F. [Centre Hospitalier Universitaire Lyon-Sud, 69 - Pierre-Benite (France)

    1997-12-31

    Pancreatic cancer still have bad prognosis. At the time of diagnosis, less than 10 % of patients can undergo surgery with an overall 5-year survival rate of less than 2 %. For patients with localized pancreatic adenocarcinoma, the combination of radiation therapy and chemotherapy has been shown to control symptoms and to enhance patient survival. This treatment should be proposed to all the patients with good performance status and without icterus. Pain management should be optimized and often need morphinic and co-antalgic (anticonvulsants, steroids) consumption. The celiac plexus block with alcohol gives an excellent pain relief and should be more frequently used. (author)

  1. Therapy choice for rectum neoplasm; Le choix des therapeutiques du cancer du rectum

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1995-06-01

    The tumour extension degree is given essentially by the rectal palpation and endo-rectal echography. The recent surgical technologies allow more and more often to keep the anal sphincter. The surgical ablation quality is a remote factor prognostic. The treatment decisions must be taken by trained pluridisciplinar teams.

  2. Microparticules magnetiques therapeutiques pour la chimio-embolisation ciblee du foie

    Science.gov (United States)

    Pouponneau, Pierre

    The proposed project introduces a therapeutic vector for the liver tumor treatment based on a new magnetic targeting strategy. The hypothesis of this thesis is that it is possible to design a therapeutic vector compatible with the constraints of liver chemoembolization and MRN in the hepatic artery to target the right/left lobe of the liver. This vector, referred to as therapeutic magnetic microcarriers (TMMC) is loaded with an antitumor drug and magnetic nanoparticles. A design study, based on a mathematical modeling of microparticle steering and a literature review on the chemoembolization, was done to optimize TMMC properties (diameter, Ms, nanoparticle choice and loading). Iron-cobalt (FeCo) nanoparticles were synthesized and annealed under inert conditions to improve their magnetic properties. These ferromagnetic nanoparticles possessed a mean diameter of 200 nm, measured by transmission electronic microscopy, and an Ms of 205 emu g-1, determined with a vibrating sample magnetometer. These nanoparticles, by their high Ms, allowed reducing by half the magnetic material loading in TMMC compared with the encapsulation of iron oxide nanoparticles. The nanoparticles coated with 10-nm graphite shell were protected from oxidation and thus they maintained their excellent magnetic properties. The design study was experimentally confirmed by the encapsulation of FeCo nanoparticles into poly(lactic-co-glycolic acid (PLGA) biodegradable microparticles. The latter were steered in vitro in a phantom mimicking the hepatic artery and its right/left bifurcation. The steering efficiency was determined by steering video analysis and the iron and cobalt ion concentrations were assayed by atomic absorption spectrometry in each bifurcation. FeCo nanoparticles were then co-encapsulated with doxorubicin (DOX) into PLGA microparticles. DOX is an antitumor drug widely used for HCC treatments. TMMC possessed a mean diameter of 52 mum, an Ms of 72 emu g-1 and they were loaded with 37% (w/w) of nanoparticles and 3% (w/w) of DOX. In vitro, after 3 days of elution in phosphate buffered saline solution, 54% of the DOX encapsulated remained in the TMMC. The elution was characterized by a fast release phase during one hour and then a slow kinetics. The steering was evaluated in vitro in a phantom mimicking the hepatic artery under physiological and interventional radiology conditions (injection by catheter, variation of distance between the catheter and the bifurcation from 30 to 20 mm, magnetic gradient from 200 to 400 mT m -1, flow velocity from 7.5 to 12 cm s-1). Steering efficiency was defined as the reduction of the TMMC (or drug) dose in the untargeted area in the presence of magnetic steering versus the negative control (no steering). The steering efficiency increased when the magnetic gradient increased. The efficiency decreased when the flow velocity increased and the catheter was closer to the bifurcation. The efficiency decreased with microparticles with lower steering properties (diameter of 30 mum and Ms of 49 emu g-1). This result confirmed that the TMMC properties were specific to the vascular network being targeted. In the optimal conditions, the steering efficiency reached 70%. The steering of TMMC was measured in vivo. An interventional radiology protocol compatible with MRN was developed to place the catheters, to reduce the hepatic artery blood velocity during the steering and to determine the MRI sequence parameters. TMMC induced signal loss on T2*-weighted magnetic resonance images because of their high Ms which allowed their easy localization in the tissues. The embolization of the hepatic artery branches by TMMC was confirmed by histological analysis. The sustained release of DOX was verified by measuring its plasmatic concentration. TMMC distribution in the tissues was determined by the histological analysis and DOX and cobalt concentration measurements. A significant difference in the TMMC distribution in the liver lobes between the group with MRN and the control group was obtained. The MRN allowed reducing the microparticl

  3. Energy efficiency: utopia or reality?; Efficacite energetique: utopie ou realite?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2006-04-15

    In its 2006 allocution the world council on the energy WEC, analyzes the role of the energy efficiency in the energy life cycle. In spite of different objectives followed by the developing and developed countries, implement a world energy efficiency economy is a challenge possible by the cooperation.The WEC is an ideal forum for the information and experience exchange. (A.L.B.)

  4. Smart Battery Thermal Management for PHEV Efficiency Une gestion avancée de la thermique de la batterie basse tension de traction pour optimiser l’efficacité d’un véhicule hybride électrique rechargeable

    Directory of Open Access Journals (Sweden)

    Lefebvre L.

    2013-03-01

    la disponibilité d’énergie de traction électrique et la durabilité de la batterie. La conception du système de gestion thermique de la batterie basse tension doit donc prendre en compte les exigences requises de la chaîne de traction et du véhicule, la conception et l’architecture du pack batterie, les contraintes d’environnement, au moindre coût et au moindre poids, etc., tout en optimisant les compromis entre ces paramètres souvent antagonistes. Le processus de conception du thermomanagement de la batterie basse tension de traction fait l’objet de la première partie de cet article. Ce processus sera illustré par deux exemples, l’un mettant en oeuvre l’air en provenance de l’habitacle du véhicule et l’autre, par un refroidissement direct via le circuit de réfrigération du véhicule. Pour une application concrète, le processus de décision doit intégrer l’ensemble des modes de thermomanagement étudiés dans ce contexte et les différents paramètres et exigences pris en compte en tant que données d’entrée. La seconde partie de l’article présente un modèle de simulation thermoélectrique simplifié de la batterie basse tension de traction. Quelques résultats de calculs seront présentés à titre d’exemples dans deux perspectives différentes, d’une part, le dimensionnement thermique du système de thermomanagement, et d’autre part, l’optimisation du bilan énergétique du véhicule. Par ailleurs, ce modèle de simulation simplifié a également permis d’identifier et d’évaluer plusieurs stratégies pertinentes de gestion thermique de la batterie. Ces stratégies visent à améliorer l’efficacité et la performance du véhicule tout en ménageant la durée de vie de la batterie. La troisième partie présente certaines de ces stratégies. Parmi celles-ci, le post-refroidissement et le préconditionnement thermique de la batterie basse tension de traction, en préchauffage par conditions froides et en

  5. Lung Aplasia with Pulmonary Artery Sling Like Anomaly

    Directory of Open Access Journals (Sweden)

    Onur Isik

    2016-04-01

    Full Text Available Unilateraly pulmonary agenesis is an extremely rare documented congenital anomaly. It may be defined as total absence of the pulmonary parencilyma, its vascular supporting structure, and bronchi beyond the bifurcation. The present case with reconstructed images is one of the different cases of agenesis reported in the literature.

  6. Targeted therapies and radiotherapy in lung cancer; Les therapeutiques ciblees en association avec la radiotherapie dans le cancer bronchique

    Energy Technology Data Exchange (ETDEWEB)

    Hennequin, C. [Hopital Saint-Louis (APHP), Serv. de Cancerologie-radiotherapie, 75 - Paris (France); Institut Curie-Orsay, Unite Inserm 612, Centre Universitaire, 91 - Orsay (France)

    2007-01-15

    Targeted therapies are now more often used in lung cancer. Inhibitors of EGFR and of angiogenesis have demonstrated a certain activity in this disease. Some experimental in vitro or in vivo studies are in favour of combined targeted therapies and radiation. For example, additive or supra-additive effects have been shown when inhibitors of the EGFR tyrosine kinase were given with radiation. In advanced lung cancer, the combination of bevacizumab with chemotherapy was demonstrated to produce better survival outcomes. But a high rate of fatal hemoptysis was reported with this drug, particularly for central and squamous tumors. This could be a limitation for its use in combination with radiation. Drugs with multiple targets are becoming available; their association with radiation seems to be promising. (author)

  7. Le Sommeil et l’Age: de la Physiopathologie a la Therapeutique (Sleep and Age: From Physiopathology to Therapeutics)

    Science.gov (United States)

    2000-08-01

    34 ; ceux du matin paradoxal, ne sont pas alterds de la m~me faqon par le supportant momns bien le travail postd. Avec: l’Age. les processus de...Echelles Visuelles netironales et dans les connections chuinlques avec le Analogiques). Les vdtdrans, peut- etre en raison de leur noyau suprachiasmatique...semble etre influencde de fagon negative -u acucseetd ~id par le vieillissement, et peut devenir responsable 11 un raccou mniricisemnstade p mrisdembebe

  8. Investigation of Methane Hydrate Formation in a Recirculating Flow Loop: Modeling of the Kinetics and Tests of Efficiency of Chemical Additives on Hydrate Inhibition Étude de la formation de l'hydrate de méthane dans une conduite de recirculation : modélisation de la cinétique et tests d'efficacité d'additifs chimiques inhibiteurs d'hydrates de gaz

    Directory of Open Access Journals (Sweden)

    Peytavy J. L.

    2006-12-01

    obstruer les lignes de transport et les installations de traitement d'effluents pétroliers. Pour contrôler ces dépôts d'hydrates, on utilise fréquemment, comme inhibiteurs, le méthanol ou les glycols. Aujourd'hui, les équilibres thermodynamiques des hydrates de gaz sont bien connus ; par contre, les cinétiques de formation et de croissance doivent être étudiées afin de mettre en évidence de nouveaux moyens de contrôle grâce à l'étude des mécanismes de formation des hydrates hors équilibre. Le présent travail propose une étude de la cinétique de formation de l'hydrate de méthane dans une boucle de recirculation de laboratoire dans laquelle le mélange liquide, saturé de méthane, circule à une pression maximum de 75 bar. La pression constante au cours des expériences est maintenue par ajout de gaz frais. Dans un premier temps, nous avons étudié les effets de la pression (35-75 bar, de la vitesse d'écoulement du liquide (0,5-3 m/s, de la rampe de refroidissement (2-15°C/h et de la quantité d'hydrocarbure présent dans la charge (0-96 % sur les cinétiques de formation de l'hydrate. Nous proposons ensuite une nouvelle méthode de prédiction, en premier lieu, des conditions thermodynamiques (pression et température correspondant aux valeurs de vitesse de croissance maximum de l'hydrate, puis de ces vitesses de croissance maximum. Nous avons obtenu un bon accord entre valeurs expérimentales et calculées. Enfin, nous avons évalué, en utilisant la procédure expérimentale décrite précédemment, l'efficacité de quelques inhibiteurs cinétiques et tensioactifs mis au point pour éviter, soit la nucléation, soit la croissance des cristaux et l'agglomératon de particules d'hydrates de méthane.

  9. Analysis and observation of T lymphocyte subsets and curative effects in patients with acquired pure red cell aplasia%获得性纯红细胞再生障碍性贫血患者的T淋巴细胞亚群分析及疗效观察

    Institute of Scientific and Technical Information of China (English)

    朱琳; 安利; 王增胜; 富玲

    2016-01-01

    Objectives To investigate distribution of T lymphocyte subsets,absolute value and proportion of large granular lymphocyte(LGL) in peripheral blood and bone marrow of acquired pure red cell aplasia (PRCA) patients,and to evaluate patients' immune function and efficacy of immunosuppressive agents.Methods From January 2002 to November 2015,a total of 25 patients with acquired PRCA who were treated at Department of Hematology,People's Hospital of Xinjiang Uygur Autonomous Region at first-visit were enrolled into this study,as study group.Inclusion criteria of study group:patients' diagnoses were conformed to the diagnostic criteria of PRCA in Diagnosis and Curative Effect of Hematology (3rd edition) and clinical data were complete.Exclusion criteria:other anemia disease and clinical data were not complete.In 25 cases of PRCA patients,5 cases were secondary PRCA with T celllarge granular lymphocyte leukemia (T-LGLL),other 20 cases were primary PRCA.And 25 cases of health people who were receiving physical examination at the People's Hospital of Xinjiang Uygur Autonomous Region during the same period were recruited into control group randomly,by simple random method.Inclusion criteria of control group:no abnormality in blood routine examination and biochemical test.Exclusion criteria:abnormality in blood routine examination,and suffering from immune disease,tumor.T lymphocyte subsets of subjects in study group and control group were detected by flow cytometry.Blood routine examination and bone marrow examination were carried out in study group before and after treatment.Then absolute value and proportion of LGL in bone marrow,peripheral blood and curative effect after drug treatment of cyclosporine A and so on of 25 acquired PRCA patients were analyzed retrospectively and compared statistically.The study protocol was approved by the Ethical Review Board of Investigation in Human at People's Hospital of Xinjiang Uygur Autonomous Region.There were no statistically

  10. La bonne ponctuation clarté, précision, efficacité de vos phrases

    CERN Document Server

    Doppagne, A

    1984-01-01

    Une faute d'orthographe peut ne mettre en cause qu'une information plus ou moins conventionnelle ; une faute de ponctuation est presque nécessairement une faute contre la logique, et c'est plus grave.

  11. La miraculeuse efficacité de la théorie quantique

    CERN Document Server

    Miné, Philippe

    2014-01-01

    Avec les théories de la relativité, la physique quantique est une de ces révolutions conceptuelles qui ont, au cours du XXe siècle, tout changé à notre compréhension de la nature. Si fascinantes que soient ses applications – laser, cryptographie, GPS, ordinateur, imagerie médicale –, la physique quantique fait cependant intervenir des paradoxes déroutants pour notre logique ordinaire. Pénétrer les arcanes du monde quantique, c’est donc aussi accepter d’utiliser le langage des équations, dont les auteurs donnent ici une approche accessible et graduée, n’excédant pas le niveau du premier cycle universitaire et n’oubliant jamais les vertus de l’approche historique. Se révèle ainsi l’univers fabuleux des particules élémentaires, des forces fondamentales de la nature, de la cosmologie et des énigmes de l’espace-temps, thèmes sur lesquels doit s’édifier toute réflexion moderne sur la nature et ses lois. Mais acquérir une certaine familiarité avec le monde quantique ne sig...

  12. L’INFLUENCE DU FLUX SOLAIRE SUR L’EFFICACITE DU CONVERTISSEUR SOLAIRE PLAN

    Directory of Open Access Journals (Sweden)

    Nadir BELLEL

    2010-06-01

    Full Text Available Le solaire thermique est une énergie gratuite, nous présentons dans cette travail une application de cette énergie. Notre étude consiste à maître en présence l’influence du flux solaire Sur la température de sortie du fluide caloporteur et le la température de la plaque d'absorbeur d’un capteur solaire plan incliné. On découper le capteur en tranches fictives dans le sens de l’écoulement du fluide caloporteur et à établir les bilans des échanges qui interviennent aux niveaux des noeuds considérés : l’extérieure de la vitre, l’intérieur de la vitre, l’absorbeur, dans le fluide colporteur ainsi que l’intérieure et l’extérieur de l’isolant. Il est commode pour cela d’utiliser l’analogie qui existe entre les transferts de chaleur et les lois électrique, les profils des températures au niveau des noeuds principaux résultats commentés. Le programme élaboré a été validé par l’étude comparative des résultats théoriques et expérimentaux pris dans les mêmes conditions.

  13. The nuclear debate: ethics versus effectiveness; Morale et efficacite dans le debat nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, D

    2009-04-15

    Following some political maneuvering, a new debate on the future of nuclear deterrence is about to resurface. And a first deadline has been set by the need to restore the strategic balance between the United States and Russia before the START Treaty ends on 5 December 2009, as well as by preparation for the next NPT Review Conference. Perception of the main threat has changed, but so have concepts of deterrence. Far from outmoded, deterrence forms part of a broader vision in which realism has the edge over idealism. (author)

  14. Electricity: France tries to restore efficiency; Electricite: la France tente de retablir l'efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Chauveau, L.; Mulot, R.

    2012-02-15

    While recalling some data regarding the French energy consumption and its costs for the French households, the authors evoke Premio, the oldest experimental smart grid in Europe, and describe its operation. They comment the experience made in Brittany where households are warned when a consumption peak occurs, and will be equipped with devices which will automatically cut the electricity in this situation. They outline the role smart grids could have in energy savings. They also comment the possibilities of the Linky smart meter and the associated network security problems

  15. Social accommodation and energy efficiency dossier; Dossier habitat social et efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Despretz, H. [Agence de l' Environnement et de la Maitrise de l' Energie, ADEME, 75 - Paris (France); Morlot, R. [Centre Scientifique et Technique du Batiment, (CSTB), 75 - Paris (France); Gibert, M. [OPAC 38, Grenoble (France); Marichez, J.M. [CDHR 62 - Arras (France); Bouchardeau, Ph. [ADIL 26 (France); Sidler, O. [Enertech, 26 - Felines sur Rimandoule (France); Hamadou, H. [Mouvement pour les Villages d' Enfants, MVE (France)

    2001-09-01

    This dossier takes stock of the experiences and programs in progress in some French regions about the enforcement of the new thermal regulation from June 2001 in social accommodations: recall of the principles of the new regulation, practices and needs for renewable energy uses in accommodations for underprivileged people; campaign of sensitization to water, electricity and heat saving; the energy policy of the OPAC 38, a social accommodation organization of Grenoble (SE France); the energy mastery in Northern France rural accommodations; the social stake of energy mastery, its impact on standard of living, health and public finances; the first lessons gained from the scheduled operations of improvement of accommodations (rehabilitation of private buildings) in Drome region (SE France); the electricity mastery action of Montreuil-Vincennes Energie organization for the evaluation of the different specific uses of electricity in common and private parts of social apartment buildings. (J.S.)

  16. Combined population balance-energy efficiency approach; Approche couplee bilan de population-efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Touil, D.; Frances, Ch. [Ecole Nationale Superieure des Ingenieurs en Arts Chimique Et Technologiques (ENSIACET), Lab. de Genie Chimique, UMR CNRS 5503, 31 - Toulouse (France); Belaadi, S. [Houari Boumediene Univ., Dept. de Chimie Industrielle, Alger (Algeria)

    2006-06-15

    The batch grinding of clinker in a laboratory ball grinding mill fitted with a device to measure the load torque is analysed in the following article. The specific speeds for the primary grinding of different particle sizes of this material are decided upon at different levels of specific consumption and for different ball diameters. On a kinetic level and based upon the population balance model, we can see that the specific selection function depends upon the ball dimensions, offering a specific maximum for a certain particle size. (authors)

  17. Energy efficiency: rehabilitation action in public housing project; Efficacite energetique: operation de rehabilitation en HLM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This document presents an operation of rehabilitation in public buildings near Paris (Montreuil). The chosen building is a four floor building built in 1969, showing a favorable solar exposition. Using a bio-climatic and a high environmental quality, the project realized 30% of energy conservation, 30% of water conservation, poor emissivity glass for windows, an outdoor insulation, vitreous balconies and the use of recycled materials. (A.L.B.)

  18. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees

    Energy Technology Data Exchange (ETDEWEB)

    Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

    2008-01-15

    Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

  19. La varicocèle de l’adulte: aspects anatomo-cliniques et resultats therapeutiques au service d’urologie-andrologie du CHU de Conakry, Guinee

    Directory of Open Access Journals (Sweden)

    A.B. Diallo

    2015-06-01

    Conclusion: La varicocèle est une pathologie fréquente dans notre pratique quotidienne; l’infertilité du couple en est la forme de découverte la plus fréquente. Le profil spermatique est celui d’une oligoasthénotératozoospermie. La cure chirurgicale améliore de façon significative la fertilité des patients hypofertiles.

  20. Indications of hematopoietic stem cell transplantations and therapeutic strategies of accidental irradiations; Indications des greffes de cellules souches hematopoietiques et strategies therapeutiques des irradiations accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Produced by a group of experts, this document first discusses the issue of accidental irradiations in terms of medical management. They notably outline the peculiar characteristics of these irradiations with respect to therapeutic irradiations. They agreed on general principles regarding casualty sorting criteria and process, and their medical treatment (systematic hematopoiesis stimulation, allogeneic transplantation of hematopoietic stem cells). They discuss some practical aspects of these issues: casualty sorting within a therapeutic perspective (actions to be performed within 48 hours), therapeutic strategies (support therapy, use of cytokines, and therapy by hematopoietic stem cell transplant). They state a set of recommendations regarding the taking into care and diagnosis, therapeutic strategies, research perspectives, and teaching

  1. Positron Emission Tomography and head and neck cancers: Recurrence and post-treatment surveillance; TEP au {sup 18}-FDG et cancers ORL: recidive et surveillance post-therapeutique

    Energy Technology Data Exchange (ETDEWEB)

    Colavolpe, C.; Guedj, E.; Tessonnier, L.; Mundler, O. [CHU La Timone, Service Central de Biophysique et de Medecine Nucleaire, 13 - Marseille (France); Fakhry, N.; Zanaret, M. [CHU La Timone, Service d' ORL et de Chirurgie Cervicofaciale, 13 - Marseille (France)

    2008-08-15

    Recurrence of head and neck squamous cell carcinomas occurs early and currently, with poor prognosis. Post-therapeutic surveillance aims to diagnose a recurrence as early as possible in order to perform curative salvage therapy. The risk of recurrence is highest in locally advanced cancers. Morphological imaging, including Computed Tomography (CT Scan) and magnetic resonance imaging, can be limited by the anatomic changes following surgery and radiotherapy, and sometimes cannot provide early diagnosis of recurrence. Histology presents some risk of morbidity, especially in irradiated tissues, and sampling error. Positron Emission Tomography (PET) with {sup 18}F-fluorodeoxyglucose (F.D.G.) is superior to conventional imaging for the diagnosis and staging of recurrence, especially when it is performed three months after the end of treatments. F.D.G.-PET has high sensitivity and negative predictive value for recurrence, so that further morphological and invasive investigations should not be performed in case of negative examination. On the other hand, because of its limited specificity and positive predictive value, any positive PET finding should be documented, in order to avoid false positives findings. The diagnosis of recurrence is the field of application in which F.D.G.-PET has the greatest impact on head and neck cancer management: it is considered as a standard. However, the interest of F.D.G.-PET during systematic follow-up has not yet been confirmed. PET should only be performed in difficult cases and within evaluation protocols. (authors)

  2. Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology; Immunovectorisation de radioelements emetteurs de particules alpha: une nouvelle voie therapeutique en cancerologie

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeois, M

    2007-05-15

    The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the {sup 131}iodine or the{sup 90}yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

  3. Mast Cell Growth Factor Enhances Multilineage Hematopoietic Recovery in Vivo Following Radiation-Induced Aplasia

    Science.gov (United States)

    1994-01-01

    lymphocyte, monocyte, tributing to morbidity and mortality associated with hemato- eosinophil , and basophil numbers, as well as an increase in...factor (ligand for c-kit) administered in murine mast cell growth factor (c-kit figand) on colony vivo to mice either alone or in combination with granu

  4. Genetics Home Reference: congenital deafness with labyrinthine aplasia, microtia, and microdontia

    Science.gov (United States)

    ... SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of ... Institutes of Health National Library of Medicine Lister Hill National Center for Biomedical Communications 8600 Rockville Pike, ...

  5. Aplasia e hipoplasia del nervio auditivo : correlación anatómico-funcional

    OpenAIRE

    Paula Vernetta, Carlos de

    2014-01-01

    La hipoacusia neurosensorial es uno de los problemas más frecuentes que afectan al recien nacido, llegando a afectar a entre 1,5 y 6 niños por cada 1000 recien nacidos vivos (Domínguez, 2011). Aunque la pérdida auditiva puede originarse en cualquier lugar de la vía auditiva es de todos conocido que la afectación más frecuente ya sea de causa congénita o adquirida se va a localizar a nivel coclear y en concreto a nivel de la célula ciliada. Estudios recientes sugieren que la disfunción del n...

  6. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia.

    Science.gov (United States)

    Bär, Christian; Povedano, Juan Manuel; Serrano, Rosa; Benitez-Buelga, Carlos; Popkes, Miriam; Formentini, Ivan; Bobadilla, Maria; Bosch, Fatima; Blasco, Maria A

    2016-04-07

    Aplastic anemia is a fatal bone marrow disorder characterized by peripheral pancytopenia and marrow hypoplasia. The disease can be hereditary or acquired and develops at any stage of life. A subgroup of the inherited form is caused by replicative impairment of hematopoietic stem and progenitor cells due to very short telomeres as a result of mutations in telomerase and other telomere components. Abnormal telomere shortening is also described in cases of acquired aplastic anemia, most likely secondary to increased turnover of bone marrow stem and progenitor cells. Here, we test the therapeutic efficacy of telomerase activation by using adeno-associated virus (AAV)9 gene therapy vectors carrying the telomerase Tert gene in 2 independent mouse models of aplastic anemia due to short telomeres (Trf1- and Tert-deficient mice). We find that a high dose of AAV9-Tert targets the bone marrow compartment, including hematopoietic stem cells. AAV9-Tert treatment after telomere attrition in bone marrow cells rescues aplastic anemia and mouse survival compared with mice treated with the empty vector. Improved survival is associated with a significant increase in telomere length in peripheral blood and bone marrow cells, as well as improved blood counts. These findings indicate that telomerase gene therapy represents a novel therapeutic strategy to treat aplastic anemia provoked or associated with short telomeres.

  7. Improving the Organisational Effectiveness of Coalition Operations (Amelioration de l’efficacite structurelle des operations en coalition)

    Science.gov (United States)

    2012-11-01

    integration and dissatisfaction with increasing cultural diversity, which in turn negatively impacts the team’s effectiveness [42],[57],[82]. Thus...integration problems, low cohesion, and dissatisfaction , which in turn can affect the team’s effectiveness negatively [42],[82]. An organisational culture...peacekeeping, thereby possibly affecting the HQ’s working processes and division of labour . Drawing on other organisational research, what is considered

  8. Energy efficiency. Buildings in the heart of the European challenge; Efficacite energetique. Le batiment au coeur du defi europeen

    Energy Technology Data Exchange (ETDEWEB)

    Rognon, C.

    2002-11-01

    The European parliament has adopted a new directive which aims at reducing the emissions of greenhouse gases in the sector of new and existing buildings. The directive requires that air-conditioning and space-heating systems must be submitted to a regular control and to an evaluation of their energy performances. Short paper. (J.S.)

  9. Energy efficiency in buildings with the natural gas; L'efficacite energetique dans le batiment avec le gaz naturel

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-11-01

    This document summarizes the content of a conference-debate organized by Cegibat, the information service of Gaz de France (GdF) for building engineering professionals, about the improvement of the energy efficiency of buildings thanks to the use of natural gas: 1 - the environmental stakes of energy savings in buildings; 2 -evolution of the regulatory context; 3 - the R and D answers of appliance manufacturers; 4 - GdF's choices and commitments; 5 - efficiency analysis (technical inspections and audits); 6 - efficiency maintenance (renovation and follow-up); 7 - conclusions. (J.S.)

  10. Technical Evaluation Report on the Flight Mechanics Panel Symposium on Piloted Simulation Effectiveness (L’Efficacite de la Simulation Pilotee)

    Science.gov (United States)

    1992-04-01

    d’importance. ,il Flight Mechanics Panel Chairman: ICA J.-M. Duc Deputy Chairman: Prof. L.M.B.da Costa Campos Directeur Pavilhio de Maquinas Affaires...that these programmes benefitted from having two levels of simulation: a simple standard, for preliminary investigations, and a more complete and...8217iISDaV. tocion syste’ rerormance, accuracy or odellinz, ano temporal rieiiCl’ All of tnese issues are complex and cona’z:onai. so -hac simple criteria

  11. Improving Human Effectiveness Through Embedded Virtual Simulation (Amelioration de l’efficacite humaine grace a la simulation virtuelle integree)

    Science.gov (United States)

    2014-01-01

    environment and direct their activity towards achieving goals (Russell & Norvig , 2003). In computer-based tutors, learning agents observe and act upon... Norvig , P. (2003). Artificial Intelligence: A Modern Approach (2nd ed.). Upper Saddle River, New Jersey: Prentice Hall, ISBN 0-13-790395-2

  12. Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks. From Contamination Analysis to the Collective Whistle-Blowing Process Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des ÉPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    Directory of Open Access Journals (Sweden)

    Alain Garrigou

    2008-05-01

    processus de certification des EPI (équipements de protection individuelle. Sur ces bases, la question des EPI sera alors abordée sous l’angle d’un transfert de technologie entre des milieux industriels et les réalités des situations agricoles. Ceci conduit à un diagnostic très préoccupant en matière d’efficacité réelle des combinaisons. Nous aborderons aussi les questions des responsabilités juridiques soulevées par de tels manquements. Enfin, nous détaillerons le rôle de whistler blower (Vaugan, 1996 que nous avons décidé de jouer ainsi que le processus d’alerte que nous avons construit afin de poser autrement le problème des EPI et intéresser l’ensemble des acteurs.El objetivo de este artículo es presentar los resultados recientes de una investigación/acción en ergotoxicología sobre los riesgos relacionados con el uso de productos fitosanitarios. Esta investigación propone una doble articulación : la primera, entre resultados que emergen de análisis realizados en situaciones de trabajo sobre la contaminación externa de los viticultores y resultados provenientes de tests de laboratorio sobre la permeabilidad de la vestimenta de protección. La segunda articulación trata de la relación entre el conjunto de resultados ya citados y un análisis de los fallos técnicos y organizacionales del diseño y de los procesos de certificación de los EPI (equipos de protección individual. La problemática de los EPI será abordada desde el ángulo de una transferencia de tecnología entre los medios industriales y las realidades de las situaciones agrícolas. Esto conduce a un diagnóstico muy preocupante sobre la eficacia real de las vestimentas de protección. Abordaremos también las preguntas sobre la responsabilidad jurídica que emergen de estas carencias. Finalmente, explicaremos el rol de whistler blower (Vaugan, 1996 que decidimos jugar y el proceso de alerta que construimos para plantear de otra manera el problema de los EPI y hacer

  13. Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des EPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks:From Contamination Analysis to the Collective Whistle-Blowing Process Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    Directory of Open Access Journals (Sweden)

    Alain Garrigou

    2008-05-01

    Full Text Available L’objectif de cet article est de présenter des résultats récents d’une recherche/action en ergotoxicologie concernant les risques liés à l’usage des produits phytosanitaires. Cette recherche propose une double articulation : la première entre des résultats issus d’analyses en situations de travail portant sur la contamination externe des viticulteurs et des résultats issus de tests en laboratoire portant sur la perméation des combinaisons. La seconde articulation concerne le lien entre l’ensemble des résultats cités ci-dessus et une analyse des failles techniques et organisationnelles de la conception et des processus de certification des EPI (équipements de protection individuelle. Sur ces bases, la question des EPI sera alors abordée sous l’angle d’un transfert de technologie entre des milieux industriels et les réalités des situations agricoles. Ceci conduit à un diagnostic très préoccupant en matière d’efficacité réelle des combinaisons. Nous aborderons aussi les questions des responsabilités juridiques soulevées par de tels manquements. Enfin, nous détaillerons le rôle de whistler blower (Vaugan, 1996 que nous avons décidé de jouer ainsi que le processus d’alerte que nous avons construit afin de poser autrement le problème des EPI et intéresser l’ensemble des acteurs.This paper presents the results of an ergotoxicologic study on the effectiveness, in real-life conditions, of the protective suits recommended by preventionists. The arguments presented in the paper are based on the Pestexpo study conducted by Isabelle Baldi (Baldi et al. (2002 and Baldi et al. (2006, which involved analyzing the exposure of vineyard workers to plant protection products by using an ergo-toxicologic approach. The point is to identify different types of exposure by taking into account the characteristics of the actual work (as opposed to what the operators are supposed to be doing as an outcome of personal

  14. Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.

    Directory of Open Access Journals (Sweden)

    Kentaro Suzuki

    Full Text Available Sirenomelia, also known as mermaid syndrome, is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Most affected infants are stillborn, and the few born alive rarely survive beyond the neonatal period. Despite the many clinical studies of sirenomelia in humans, little is known about the pathogenic developmental mechanisms that cause the complex array of phenotypes observed. Here, we provide new evidences that reduced BMP (Bone Morphogenetic Protein signaling disrupts caudal body formation in mice and phenocopies sirenomelia. Bmp4 is strongly expressed in the developing caudal body structures including the peri-cloacal region and hindlimb field. In order to address the function of Bmp4 in caudal body formation, we utilized a conditional Bmp4 mouse allele (Bmp4(flox/flox and the Isl1 (Islet1-Cre mouse line. Isl1-Cre is expressed in the peri-cloacal region and the developing hindimb field. Isl1Cre;Bmp4(flox/flox conditional mutant mice displayed sirenomelia phenotypes including hindlimb fusion and pelvic/urogenital organ dysgenesis. Genetic lineage analyses indicate that Isl1-expressing cells contribute to both the aPCM (anterior Peri-Cloacal Mesenchyme and the hindlimb bud. We show Bmp4 is essential for the aPCM formation independently with Shh signaling. Furthermore, we show Bmp4 is a major BMP ligand for caudal body formation as shown by compound genetic analyses of Bmp4 and Bmp7. Taken together, this study reveals coordinated development of caudal body structures including pelvic/urogenital organs and hindlimb orchestrated by BMP signaling in Isl1-expressing cells. Our study offers new insights into the pathogenesis of sirenomelia.

  15. Conformal radiotherapy to 76 Gy in localized prostate cancer. Therapeutic modalities and preliminary results; Radiotherapie conformationnelle a 76 Gy des cancers localises de la prostate. Modalites therapeutiques et resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Pontvert, D.; Mammar, H. [Institut Curie, Dept. d' Oncologie Radiotherapique, 75 - Paris (France); Flam, T.; Debre, B. [Hopital Cochin-Saint-Vincent-de-Paul, Service d' Urologie, 75 - Paris (France); Thiounn, N. [Hopital Necker-Enfants-Malades, Service d' Urologie, 75 - Paris (France); Gaboriaud, G. [Institut Curie, Service de Physique Medicale, 75 - Paris (France); Jourdan-Da Silvae, N. [Institut Curie, Service de Biostatistique et d' evaluation clinique, 75 - Paris (France); Beuzeboc, P. [Institut Curie, Dept. d' Oncologie Medicale, 75 - Paris (France)

    2008-03-15

    Purpose: to describe therapeutic modalities for localized prostate cancer treated by conformal radiation to 76 Gy with or without androgen ablation. To evaluate the preliminary results in terms of survival, biological control and toxicity. Patients and method: between January 1998 and June 2001, 321 patients with localized prostate cancer were irradiated at Institut Curie. Tumors were stratified into the three Memorial Sloan-Kettering Cancer Center prognostic groups (1998) for analysis: favorable risk group (F.G.) 23%, intermediate risk group (I.G.) 36.5%, unfavorable risk group (U.G.) 40.5%. Androgen deprivation, mainly neo-adjuvant, less or equal to one year was prescribed to 93.8% of patients (72.6% less or equal to six months). Planning target volume prescription doses were: prostate: 76 Gy, seminal vesicles: 56 to 76 Gy, and pelvic lymph nodes: 44 Gy to 16.8% of patients. Results: the five-year actuarial overall survival was 94% (95% I.C.: 90-97%). The median post-therapeutic follow-up was 36 months (nine to 60 months). The 48-month actuarial rates of biochemical control for the three prognostic groups were statistically different according to both the American Society for Therapeutic Radiology and Oncology consensus (A.S.T.R.O. 1997) and the Fox Chase Cancer Center definitions of biochemical failure (F.C.C.C. 2000) with respectively 87 and 94% for F.G., 78 and 84% for I.G., 54 and 58% for U.G. (P < 10-6 and P < 10-8). At time of our analysis, late post-treatment rectal and bladder bleedings were 17,4 and 13,6%, respectively. According to a 1-4 scale adapted from M.D. Anderson Cancer Center criteria: rectal bleedings were grade 1 (9.6%), grade 2 (6.2%) and grade 3 (1.6%). Bladder bleedings were grade 2 (13%) and grade 3 (0.6%). Analysis of rectal bleeding risk factors showed significant correlations with pelvic lymph nodes irradiation for grade 2 and 3, (P = 0.02), and for all grades, a correlation with smaller rectal wall volumes (P = 0.03), and greater percentages of rectal wall irradiated to higher doses: 65, 70, 72 and 75 Gy (P = 0.02, P = 0.01, P = 0.0007 and P 0.003, respectively). Conclusions: these results are comparable to those previously reported with the same follow-up. Impact of dose escalation with short androgen deprivation on local control, survival and complications needs longer follow-up and further analysis. (authors)

  16. New procedures to measure synthase and phosphatase activities of bis-phosphoglycerate mutase. Interest for development of therapeutic drugs; Nouveaux procedes pour mesurer les activites synthase et phosphatase de la bisphosphoglycerate mutase. Interet pour le developpement de drogues therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Ravel, P.; Garel, M.C. [Hopital Henri-Mondor, 94 - Creteil (France); Toullec, D. [Laboratoire Glaxo Wellcome, 91- Les Ulis (France)

    1997-12-31

    In red blood cells, a modulation of the level of the allosteric effector of hemoglobin, 2,3-diphosphoglycerate (2,3-DPG) would have implications in the treatment of ischemia and sickle cell anemia. Its concentrations is determined by the relative activities of the synthase and phosphatase reactions of the multifunctional bis-phosphoglycerate mutase (BPGM). In this report we develop first a more direct synthase assay which uses glyceraldehyde phosphate to suppress the aldolase and triose phosphate isomerase reactions. Secondly we propose a radioactive phosphatase assay coupled to chromatographic separation and identification of the reaction products by paper electrophoresis. Such identification of these products allows us to show that the multifunctional BPGM expresses its mutase instead of its phosphatase activity in conditions of competition between the 3-phosphoglycerate and the 2-phospho-glycolate activator in the phosphatase reaction. These two more precise procedures could be used to study the effects of substrate and cofactor analogues regarding potential therapeutic approaches and could be used for clinical analyses to detect deficiency of BPGM. (author)

  17. To understand and manage the digestive radiation injuries: importance of the mucous reaction and new therapy orientations; Apprehender et gerer les lesions radiques digestives: importance de la reaction muqueuse et nouvelles orientations therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Francois, A

    2007-09-15

    Actually the radiotherapy that concerns 50% of anti tumoral treatments is accompanied by side effects. The evolution of this therapy turns towards the limitation of the early effects but also the delayed effects in order to improve the quality of life of patients. The first answer was to reduce the radiation doses and the irradiated volume. Three directions are to be kept in mind concerning the digestive tissues: Fight against the break of the epithelial homeostasis by increasing the pool of cells before irradiation and by facilitating the processes of restoration and epithelial regeneration by the stimulation of the proliferation of the cells of progenitor compartments; Fight against the phenotype changes of the cells, and more globally against the cellular activation and its consequences: activation of the vascular endothelium and the initiation of the inflammatory and thrombosis processes; activation of the vascular smooth muscular cells and stenosis; oxidative stress and tissue hypoxia; recruitment and activation of the mesenchyme cells and matrix unbalance; to consider the global nature of the secondary effects, and become aware that there is, besides the physical twilight connected to the irradiation configuration, a biological twilight, that is to say a potential repercussion of the irradiation effects out of the field, on the global nature of an organ even an organism, and this in the therapy and accident configurations. (N.C.)

  18. A prospective study of the early clinical symptoms following a 2 Gy therapeutic whole-body irradiation; Etude prospective de la symptomatologie clinique precoce apres irradiation corporelle totale therapeutique de 2 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Fizazi, K.; Chaillet, M.P.; Fourquet, A.; Jammet, P.; Cosset, J.M. [Institut Curie, 75 - Paris (France)

    1995-10-01

    Early human tolerance following total body irradiation (TBI) according to the dose received is still poorly known. Thirteen selected patients were prospectively evaluated for clinical side effects during the first 10 hours following a 2 Gy TBI prior to bone marrow transplantation. All of them but one were treated for haematological malignancies and were in clinical remission at the date of TBI. There were 10 males and 3 females, with a median age of 43 y (range 16*61) and a good performance status (WHO 0-1). They received granisetron (3 mg) injected intravenously 1 h before the time of TBI in order to prevent nausea and vomiting. The main symptoms consisted in drowsiness (69%), headache (62%), xerostomia (62%), nausea and vomiting (46%), anorexia (38%), parotid gland pain (23%) and abdominal pain (8%). Their intensity was always moderate, except for 2 patients who experimented severe vomiting. The incidence rate and the time-course of the symptoms of the prodromal phase may proved to be helpful for early clinical evaluation and triage of victims of an accidental irradiation. In particular, absence of fever at the 6{sup th} h after TBI supports the assumption of an estimated exposure dose below 2 Gy. (authors). 23 refs., 2 tabs.

  19. Pediatric nasopharyngeal carcinoma: Anatomo-clinic aspects, therapeutic results and progressive particularities;Le cancer du cavum de l'enfant et l'adulte jeune: aspects anatomocliniques, therapeutiques et particularites evolutives

    Energy Technology Data Exchange (ETDEWEB)

    Frikha, M.; Toumi, N. [Service de carcinologie medicale, CHU Habib-Bourguiba, Sfax (Tunisia); Ghorbel, L.; Ben Salah, H.; Daoud, J. [Service de carcinologie radiotherapie, CHU Habib-Bourguiba, Sfax, (Tunisia); Khabir, A.; Boudawara, T. [Service d' anatomopathologie, CHU Habib-Bourguiba, Sfax (Tunisia); Karray, H. [Service de virologie, CHU Habib-Bourguiba, Sfax (Tunisia); Gargouri, R. [Centre de biotechnologie, Sfax (Tunisia); Ghorbel, A. [Service d' ORL, CHU Habib-Bourguiba, Sfax (Tunisia)

    2010-06-15

    Purpose We retrospectively analyzed anatomo-clinic, therapeutic and progressive particularities of 74 young patients (= 20 years) with nasopharyngeal carcinoma treated between 1993 and 2005. Patients and methods Initial work-up included a fiberoptic naso-fiberscopy with biopsy, computed tomography and/or MRI of nasopharynx and neck, chest X-ray, abdominal ultrasonography and bone scan. Patients were treated with either primary chemotherapy (epirubicin and cisplatin) followed by radiotherapy or concomitant radio chemotherapy (five fluorouracil and cisplatin). Radiotherapy was delivered to a total dose of 70 to 75 Gy to nasopharynx and involved cervical lymph nodes and 50 Gy to the remainder cervical areas. Results The median age was 16 years. Sixty-three percent of patients had undifferentiated tumors. Sixty-six percent had locally advanced tumor. With a median follow-up of 107 months, one patient presented a local relapse, 24 patients developed distant metastases with a median delay of 7 months. The 5 years overall survival and disease-free survival were 66 and 65 %. Late complications were dominated by dry mouth and endocrine disorders. Comments Pediatric nasopharyngeal carcinoma is characterized by an early metastatic diffusion. Local control is excellent but with severe late toxicities. New techniques of radiotherapy and new molecules of chemotherapy could improve these results. (authors)

  20. Place of the radiotherapy in the care of the extra-mammary Paget disease; Place de la radiotherapie dans la prise en charge therapeutique de la maladie de Paget extramammaire

    Energy Technology Data Exchange (ETDEWEB)

    Yanes, B.; Notter, M.; Dragusanu, D. [Hopital Neuchatelois, La Chaux-De-Fonds (Switzerland)

    2007-11-15

    The cutaneous tolerance of the radiotherapy was satisfactory and the treatment took place continuously at all the patient's. A patient is always in situation of clinical forgiveness, 3 years after the irradiation and another waits after two years, and finally a extra-mammary disease of Paget did it again 1 year after the irradiation and was treated by surgery of correction. It is still too much early to estimate the last two patients, treated in 2007. (N.C.)

  1. What is the future of the children after therapeutic irradiation of their mother during their pregnancy?; Que deviennent les enfants dont les meres ont ete irradiees a visee therapeutique pendant leur grossesse?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2008-12-15

    Abnormalities in children exposed to radiation during gestation occur more specially when the mother irradiation is made between the third and the eleventh week of pregnancy. However a case is reported through a child irradiated in utero and whom development is normal. So, more than a proposition of abortion to the parents it would be convenient to propose a long term surveillance by pediatricians and register these cases in a national data base, this rounding up of knowledge will allow to consolidate the advices that could be given to the parents on taking any precaution in this particularly difficult context. (N.C.)

  2. Energy sources consumption: end uses, efficiency and productivity; La consommation des sources d'energie: utilisations finales, efficacite et productivite

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J.M. [Institut d' Economie et de Politique de l' Energie (CNRS- UPMF), 38 - Grenoble (France)

    2005-07-01

    This document analyzes the impact of the choices made by all actors, from the energy producers to the process and infrastructure designers and the end users, in the evolution of energy consumptions. Some very little improvements made in the energy efficiency of appliances can become equivalent to the production of several oil fields or power plants at the world scale. More efficient energy uses will not replace the additional productions but they must be considered together to be compared. The energy files are first analyzed as a whole in order to show the hidden field of energy choices. In this framework, users, designers and fitters have to face very different choices because they consider efficiency improvements under different aspects: scientifical, technical, economical and social (public information and habits). These differences in efficiency uses have a time and spatial impact on the growth of energy consumption. The economical and social factors influence the collective way to consume energy and are expressed by the energy intensity of the economic activity. The last part of this document analyzes the influence of this notion on the world energy consumption scenarios at the 2050 prospects. (J.S.)

  3. Saving energy in China; Perspectives de la Chine: efficacite energetique, emissions de gaz a effet de serre et environnement. La filiere charbonniere et l'habitat

    Energy Technology Data Exchange (ETDEWEB)

    Bourrelier, P.H.

    2002-10-01

    Will China's impressive prospects for growth steeply increase emissions of greenhouse gases? Unfortunately, yes, given that its major source of energy is coal. An assessment of happenings in the field and the results of an underway program supported by the French World Environment Fund (FFEM) show, however, that China has a wider range of possibilities than developed countries. Since the beginning of the nineties Chinese authorities have been leading a program in order to tackle the chronic problems that originate in an obsolete coal industry: massive deficit of public mine utilities, congested rail transport, high level of pollution in urban areas, dramatic environmental impacts in rural zones, energy resources wasting and accidents. The main measure was to create a coal market promoting quality standards. This measure has led to the closure of thousands of small mine companies that were unable to modernize. The result was also a dramatic drop in the coal consumption: from more than 1 milliard tons a year to less than 800 million tons, this reduction had no impact on the gross national product that has continued increasing at a good pace. Another problem concerning energy consumption is the low quality of accommodation in terms of energy conservation. FFEM has launched a cooperation program between western experts and Chinese property developers, the aim is to cut by half heating bills in new housing with an extra building cost of only 10%. (A.C.)

  4. Energy efficiency at the St-Guillaume cheese factory, a profitable choice; L'efficacite energetique a la fromagerie St-Guillaume, un choix profitable

    Energy Technology Data Exchange (ETDEWEB)

    Tremblay, P.; La Roche, R. [Fromagerie St-Guillaume, Saint-Guillaume, PQ (Canada)

    2009-12-15

    The Co-op Agrilait de St-Guillaume is located at near Drummondville, Quebec. The facility employs 160 people to produce 3 million kilograms of cheese annually. In addition, 21 million litres of whey are produced. This sub-product of cheese is turned into powder to make ice cream, protein shakes, energy drinks, and feed for animals. The cost of transforming whey had gone up over the last five years, which also cut into the operating budget. Whey transformation also consumed large amounts of well water. In order to address these challenges, the energy consumption of the facility was evaluated in an effort to lower the energy costs by 30 per cent, lower water consumption and reduce water pollution. The study identified and measured the energy consumption for each activity related to the whey transformation process. The equipment and procedures used in the facility were subsequently modernized and the air quality in the facility was also improved. The improvement in whey transformation rendered the facility profitable again. The project was financed by capital loans over a ten year period, and the money saved during the first year was over $400,000. The money saved over the next 10 years will be more than 2 million dollars. 5 figs.

  5. Modélisation Bond Graphs en vue de l'efficacité énergétique du bâtiment

    OpenAIRE

    Abdelatif, Merabtine

    2012-01-01

    2012; Our works focus on the setting of reliable tools able to analyze the interaction between the building envelope and HVAC systems. The developed approach is based on Bond Graphs methodology, a graphical modeling language which is particularly suitable for energy exchanges. A numerical model gathering, under the same simulation environment, sub-models representing the building envelope, the solar gains, the floor heating, the chilled ceiling and the ventilation system, is developed in orde...

  6. L'efficacité de l'aromathérapie en élevage caprin pour lutter contre le parasitisme interne

    OpenAIRE

    Lèbre, Amélie

    2015-01-01

    Le parasitisme interne est une maladie infectieuse qui impacte la productivité des animaux et dégrade leur état sanitaire. Ces dernières décennies, de nombreux cas de résistance des strongles aux anthelminthiques conventionnels ont été observés, notamment chez les petits ruminants. Ce phénomène est devenu une préoccupation majeure des éleveurs qui doivent se tourner vers des méthodes de lutte alternatives. Dans le Sud de la France, où la production de plantes médicinales est importante, des t...

  7. The energy of a building : the simplicity and efficiency of a hybrid system; Energie de batiment : simplicite et efficacite d'un systeme hybride

    Energy Technology Data Exchange (ETDEWEB)

    Beaule, C. [SNC-Lavalin, Montreal, PQ (Canada)

    2007-06-15

    Hydronic hybrid heat pump (HHHP) systems are suitable for recuperating the energy from air conditioners and transferring it to the perimeter of buildings. This principal can be applied when interior air conditioning is required throughout the year in a building, while the periphery of the building requires air conditioning or heating during specific times of the year. The transfer of heat from the air conditioner to the periphery of buildings can be compared to a type of internal geothermal system. This article presented two case studies involving extensive heating ventilation and air conditioning (HVAC) retrofits. They both had different needs. The 7-storey Hotel Place D'Armes in Montreal is 135 years old, and uses electricity and natural gas as source of energy. It was important to choose an HVAC system that would be in accordance with the architectural style of the building while facilitating repair and upkeep of a sustainable HVAC system. The 7-storey Isabella-Decarie office building is 45 years old and also uses electricity and natural gas. The requirements of this building were to adapt the new HVAC system into the restrained space on each level; reduce HVAC energy costs; reduce the size of the mechanical rooms to simplify upkeep; retrofit without disturbing the clientele; upgrade thermal comfort; select a sustainable HVAC system that could be readily adapted to the building's future energy needs; and, stay within the budget. The historical and patrimonial aspects of the building were the main constraints in the renovation projects. The 3 major factors that led to the selection of the HHHP system were: (1) the modular HVAC units could be repaired by staff within 30 minutes and the installation of cooling pipes for the ventilation shafts were readily adaptable to the historical building, (2) the cooling system was composed of two pipes rather than four, requiring a less cumbersome installation of HVAC ducts, thereby reducing mechanical installation costs, and (3) the flexibility of the modular HVAC systems permitted the expansion of the network without affecting the operation of the rest of the building. In the end, the energy performance of the HHHP was different for each building. The energy consumption of natural gas for the heating portion was reduced by 70 per cent for the Isabella-Decarie building. Also, beyond the energy savings, the thermal comfort for the occupants was significantly improved. 9 figs.

  8. Improved efficiency thanks to modulated power - Exergy analyses show the way; Une meilleure efficacite grace au reglage continu de la puissance. Des analyses exergetiques montrent le chemin

    Energy Technology Data Exchange (ETDEWEB)

    Wellstein, J.

    2009-07-01

    This article summarizes the results of two research projects conducted at the University of Applied Sciences in Lucerne, Switzerland and supported by the Swiss Federal Office of Energy. Following the rapid development of the heat pump market for space heating in the past decades in Switzerland, the improvement of the heat pump coefficient of performance COP becomes a highly relevant issue. The problem is especially acute for air/water heat pumps, due to the fact that the COP significantly decreases when the outdoor air temperature decreases. However, laboratory measurements show that the COP could be much higher at intermediate heat load if less irreversibility in the thermodynamic cycle would occur. The Lucerne researchers have identified the exergy loss origins. Continuous heat power modulation instead of ON/OFF control of the heat pump compressor is one way for COP improvement. Another need for optimization was found in the construction of the finned lamellar heat exchanger used as evaporator. This can significantly reduce fin icing and, consequently, the power consumption during deicing.

  9. Comparison of the efficiency of several methods of surface decontamination; comparaison de l'efficacite de quelques procedes de decontamination surfacique

    Energy Technology Data Exchange (ETDEWEB)

    Duigou, A.; Fattahi, M. [Subatech, Ecole des Mines de Nantes, 44 (France); Fazileabasse, J. [Electricite de France (EDF R and D), Dept. Simulation et Traitement de l' Information pour l' Exploitation des Systemes de Production, 78 - Chatou (France)

    2009-07-15

    The study of surface decontamination of radioactive waste packages is an important project for EDF in the context of decommissioning. This study has two objectives: firstly, to reduce dosimetry due to the control of non-contaminated area of radioactive waste packages and secondly to ensure the non-contamination of surface parcels as they are sent to their final destination (treatment site and/or storage). This serves to avoid the suspension and the filling of labile activity in the transport of packages that could lead to locally exceeding the regulatory surface contamination threshold. For that purpose, a bibliographical study of the methods of decontaminations proposed in the literature was made. This study allowed seeing if techniques could answer the chosen criteria. Techniques seeming to be able to answer the requirements were then tested to estimate their efficiency. The bibliographical study and the tries of qualification showed that a method seemed more adapted than the others to our problem.

  10. The fight against the greenhouse effect. Equity and efficiency; La lutte contre l'effet de serre. Equite et efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Vallee, A. [Paris-12 Univ., 94 - Creteil (France)

    2003-07-01

    The author discusses the definition of an equitable division rule of the global effort of greenhouse gases emissions decrease, the research of the economic efficiency, the flexibility mechanisms and the emissions trading. (A.L.B.)

  11. Presented at the AGARD Conference on Piloted Simulation Effectiveness, held in Brussels, Belgium on 14-17 October 1991 (L’Efficacite de la Simulation Pilotee)

    Science.gov (United States)

    1992-02-01

    l’avion pendant Ia phase inforimations de pilotffe 6fe 3). L ia simule an de tir air-sol, trois concepts ont Wt examin~s. tableau de bord sizpii...conclusion c eat quo Ie Principe de pilotage a. en place droite, avec one planclie do bord classi- direct des pa~rarmeres pnte/routc/wtessc initdresse...simulation dans le cadre des activitds d’autorisation de vol; - l’emploi de la simulation pour r’entrainement au pilotage ; - l’emploi et le potentiel

  12. Nouveaux critères pour juger de l'efficacité d'un fourneau à la combustion du charbon de bois

    Directory of Open Access Journals (Sweden)

    Ndaysenga, M.

    1994-01-01

    Full Text Available New Criteria to Judge Stove Efficiency in the Charcoal Combustion. The water boil test efficiency for choosing the most economic stove in combustion is estimated on the basis of four stoves. In addition to the heating and boiling energy usually considered as selection criterion, other criteria such as the boiling time and the combustion rate have been taken to indicate efficiency. Strangely, it appeared that the stove which maintains water at its boiling point for a long time and has the lowest combustion rate doesn 't valorize fuel energy efficiently if you only keep to the heating and boiling energy. The cooking test made it possible to explain that apparent contradiction : the fuel energy fraction which doesn't enter in the calculation of the heating and boiling energy isn't really lost. A low combustion rate associated with a long boiling time proved to be the best criteria of choosing the most economic stove in fuel. Therefore, the only water boil test doesn't make it possible to identify the most economically efficient stove. Resorting to the cooking test is compelling.

  13. Lavage de sols pollués par des métaux lourds : efficacité et optimisation du procédé

    OpenAIRE

    Ferraro, Alberto

    2015-01-01

    The object of the present research work is the optimization of soil-washing processes applied to heavy metal contaminated soils. The work focuses on the whole cycle of these treatments, including the possible recovery and the proper disposal of the used washing solution. Both the design and the exploitation of a soil washing treatment are investigated, in order to maximize their efficacy, in terms of cost and process efficiency. At this aim process parameters and reactor configurations are st...

  14. Mieux parler pour ensuite apprendre à lire. Mesure de l'efficacité de l'action Coup de Pouce LANGAGE

    OpenAIRE

    Canut, Emmanuelle

    2010-01-01

    L'article présente une première synthèse de résultats obtenus sur une période de deux ans (2007-2009) dans cinq villes permet de confirmer les résultats issus de l'expérimentation initiale menée à Angers et de mettre en évidence l'impact du Coup de Pouce LANGAGE sur le développement langagier et le rapport à l'écrit ainsi que les implications en termes de comportement scolaire

  15. L'"efficacité paradoxale" de la médiation esthétique et le rôle du conflit

    OpenAIRE

    Servais, Christine

    2015-01-01

    Il s’agit ici de montrer que le concept de médiation a une portée critique, qu’il s’agit d’un concept propre à séparer, à distinguer, à révéler des enjeux politiques, qu’il n’est pas seulement propre à décrire des pratiques, mais également à les interroger. Le concept de médiation a une portée critique dès lors qu’il questionne le rapport entre communication et politique, notamment à travers la question des normes communes, du “sens commun”, de la transmission, du rôle du conflit, etc. En...

  16. Presentation of the national program for the improvement of the energy efficiency; Presentation du programme national d'amelioration de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    This paper is the presentation of the energy mastership national program. It deals with the actions leading to the development of the enterprises and household demand, the increase of the actions in favor of the energy, the actions in the transportation sector, the actions in the habitat domain, the mastership of the energy consumption for the industrial and service sector industries, the renewable energies development, the ADEME devices. (A.L.B.)

  17. Climatic change and energy efficiency: what kind of stakes for the building?; Changement climatique et efficacite energetique: quels enjeux dans le batiment?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    More than 22% of the greenhouse gases are emitted by the building sector. In a context of a climatic change preoccupation, the authors wonder on the possibilities to reduce these emissions in the construction industry. The energy sources and the works on standards elaboration are discussed. (A.L.B.)

  18. Paramètres pour une efficacité accrue de la lecture hypertextuelle en langue seconde Paths Towards Efficient Hypertext Reading in a Second Language

    Directory of Open Access Journals (Sweden)

    Linda de Serres

    2004-12-01

    Full Text Available Tant la lecture à l’écran que celle sur papier occupent une place importante dans nos activités quotidiennes. Toutefois, comme praticien, les avons-nous déjà comparées ? Avons-nous tenté de circonscrire en quoi l’une peut différer de l’autre ? Sans prétendre à une quelconque exhaustivité des différences possibles entre ces deux supports de lecture, nous nous sommes prêtée à l’exercice. Il en ressort une vingtaine de différences. De là, nous nous interrogeons à savoir comment le praticien peut aider le lecteur-navigateur en langue seconde à lire plus efficacement à l’écran ? À partir des protocoles oraux de huit étudiants francophones de 1er cycle ayant lu un hypertexte en anglais langue seconde (L2, nous dégagerons des éléments de réponse. Par le biais d’extraits des verbalisations introspectives des participants nous mettrons en évidence des paramètres à considérer dans cette tâche exigeante qu’est la lecture à l’écran en L2. Nous espérons que ces paramètres soutiennent le praticien désireux de poser des choix éclairés dans un cadre où il évolue avec des lecteurs en L2, dans un cadre où en ce début de XXIe siècle, la lecture à l’écran et la L2 font souvent tandem.Both reading on screen and reading on paper are now of great importance in our daily activities. However, as practitioners, have we ever thought of comparing them? In the present article, we will first compare these two types of reading by considering 20 possible differences. This comparison will lead us to a question: how can we help the second language reader to be more efficient when reading on screen? Suggestions will be made based on ideas drawn from introspective verbal protocols collected during an experiment involving eight French-speaking undergraduate students who were met on an individual basis and who were asked to read a hypertext in English. Pragmatic avenues for practitioners will be suggested. At the turn of the twenty-first century, when an increasing number of undergraduate students must cope not only with hypertext reading but also with a second language, being acquainted with ways of helping them is becoming essential.

  19. Etude de l'efficacité des antibiotiques dans le traitement des infections cérébrales a germes non isolées

    OpenAIRE

    Benedict, Mandizvidza Mutimba; Bouderga, Soufyane

    2013-01-01

    Avant de choisir un antibactérien, le clinicien doit d'abord tenir compte de deux facteurs: • Le patient • L'agent causal connu ou probable. Les facteurs liés au patient devant être considérés sont les antécédents d'allergie, la fonction rénale et hépatique, la résistance à l'infection (si immunodéprimé), la capacité à tolérer les médicaments par voie orale, la gravité de la maladie, l'origine ethnique, l'âge et si c'est une femme, le fait qu'elle soit enceinte, qu'elle alla...

  20. Etude comparative relative à l’efficacité énergétique de deux appartements situés à Béchar, Algérie

    OpenAIRE

    BENOUDJAFER, I.; Ghomari, F.; Mokhtari, A.

    2012-01-01

    The aim of this paper is the Comparative Study on Energy Efficiency of two apartments which is located in Bechar (Algeria). In this regard, simulations were performed using the software simulation of thermal behavior in dynamic ‘TRNSYS 16’ with the numerical model type 56. This project is the introduction of insulating materials in buildings to improve thermal comfort and reduce energy consumption. Various solutions have been proposed or variants, which can make a relevant choice...

  1. Energy efficiency drivers in Europe. Regulations and other instruments open new horizons for energy management in buildings; Batiments intelligents, confort et efficacite energetique active. Leviers d'efficacite energetique en Europe. Les reglementations et autres instruments incitatifs ouvrent de nouveaux horizons pour la gestion de l'energie dans les batiments

    Energy Technology Data Exchange (ETDEWEB)

    Obara, H. [Schneider Electric, 92 - Rueil-Malmaison (France)

    2010-09-15

    Curbing climate change and global warming will be one of the major challenges of the 21. Century.The very survival of our society could be at stake. Greenhouse gases including CO{sub 2} have been identified as the culprits and the vast majority of industrialized countries have agreed to cut emissions drastically over coming decades. Buildings account for nearly 40% of the energy used in most countries and are responsible for a similar level of global CO{sub 2} emissions. Energy efficiency in buildings is therefore one of the keys to reducing green-house emissions. The main driving force to achieve the ambitious goals that have been set for the reduction of greenhouse gases will come from energy efficiency regulations, building codes, standards, labels, certifications, obligations and incentives, all of which have been multiplying steadily over recent decades. International institutions are rolling out energy efficiency directives and standards that set minimum requirements for buildings.They are gradually being taken into account in national regulations and building codes. Today, most energy efficiency regulations concern building design. They hardly touch on Energy Management aspects that can generate major operational gains with relatively low investments and quick payback. Beyond regulations that focus on minimum requirements, environmental performance labels use building rating criteria that can take energy efficiency much further.They offer a practical way of assigning value to energy efficiency and in this way represent powerful market drivers. Moreover, the important benefits of Energy Management can be easily integrated in the rating criteria of these far-reaching schemes. Indeed, through effective building measurement, monitoring and control systems, Energy Management is one of the keys to rapidly reducing carbon emissions and achieving climate change targets. (author)

  2. Treatment of patients with a congenital transversal vaginal septum or a partial aplasia of the vagina. The vaginal pull-through versus the push-through technique.

    NARCIS (Netherlands)

    Bijsterveldt, C.D. van; Willemsen, W.N.P.

    2009-01-01

    STUDY OBJECTIVE: The aim of this study is to describe the different modalities of congenital obstructing vaginal malformations and the evaluation of techniques to solve the problem. DESIGN: A retrospective study. SETTING: The University Hospital Nijmegen, the Netherlands. PARTICIPANTS: The medical r

  3. Isolated right pulmonary artery agenesis with aplasia of right upper lobe and with anomalous arterial supply from celiac axis, anomalous venous drainage

    Directory of Open Access Journals (Sweden)

    Tushar Madhav Kalekar

    2015-01-01

    Full Text Available Pulmonary artery agenesis is the complete absence of the right or left pulmonary artery. This lesion is commonly associated with other cardiac anomalies and is usually diagnosed incidentally. Unilateral absence of pulmonary artery with lung hypoplasia is very rare. Ipsilateral hypoplastic or absent central pulmonary artery in these patients will have a systemic arterial supply to peripheral pulmonary arteries of the affected lung from the descending thoracic or upper abdominal aorta. These findings are usually characterized as pulmonary veno lobar syndrome or scimitar syndrome when associated with ipsilateral total or partial anomalous pulmonary venous return from the lower lobe which drains into the inferior vena cava or less commonly to the hepatic, azygous, or portal vein, or into the right atrium and lung agenesis/hypoplasia.

  4. Autologous cell therapy as a new approach to treatment of radiation-induced bone marrow aplasia: preliminary study in a baboon model

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Drouet, M. [Radiohematology Unit, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    The sparing of viable hematopoietic stem and progenitor cells located in underexposed bone marrow territories associated with the relative radioresistance of certain stem cell populations is the rationale for autologous cell therapy consisting of ex vivo expansion of residual cells after collection postirradiation. The feasibility of this treatment mainly depends on time constraints and hematopoietic cell threshold. We showed in this study that in the absence of early-acting mobilizing agent administration, subliminar amounts of CD34{sup +} cells can be collected (1 x 10{sup 6} CD34{sup +} cells/100 mL bone marrow or for 1 L apheresis) from 6-Gy {gamma} globally irradiated baboons. Residual CD34{sup +} cells were successfully expanded in serum-free medium in the presence of antiapoptotic cytokine combination (stem cell factor + FLT-3 ligand + thrombopoietin + interleukin 3, 50 ng/mL each, i.e., 4F): K{sub CD34{sup +}} = x2.8 and x13.7 (n=2). Moreover, we demonstrated the short-term neutrophil engraftment potential of a low-size mixed expanded graft (1.5 x 10{sup 6} final CD34{sup +}cells/kg) issued from the coculture of unirradiated (20%) and 2.5-Gy in vitro irradiated (80%) CD34{sup +} cells on an allogeneic stromal cell layer in the presence of 4F. Further preclinical research needs to be performed to clearly establish this therapeutic approach that could be optimized by the early administration of antiapoptotic cytokines. (author)

  5. Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract.

    Science.gov (United States)

    Tham, Ching S; Chakravarthi, Srikumar; Haleagrahara, Nagaraja; DE Alwis, Ranjit

    2013-02-01

    Lead causes damage to the body by inducing oxidative stress. The sites of damage include the bone marrow, where marrow hypoplasia and osteosclerosis may be observed. Leaves of Carica papaya, which have antioxidant and haemopoietic properties, were tested against the effect of lead acetate in experimental rats. The rats were divided into 8 groups; control, lead acetate only, Carica papaya (50 mg and 200 mg), post-treatment with Carica papaya (50 mg and 200 mg) following lead acetate administration and pre-treatment with Carica papaya (50 mg and 200 mg) followed by lead acetate administration. The substances were administered for 14 days. The effects were evaluated by measuring protein carbonyl content (PCC) and glutathione content (GC) in the bone marrow. Histological changes in the bone marrow were also observed. The results showed that Carica papaya induced a significant reduction in the PCC activity and significantly increased the GC in the bone marrow. Carica papaya also improved the histology of the bone marrow compared with that of the lead acetate-treated group. In summary, Carica papaya was effective against the oxidative damage caused by lead acetate in the bone marrow and had a stimulatory effect on haemopoiesis.

  6. Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection.

    Science.gov (United States)

    Sreedharanunni, S; Sachdeva, Mus; Prakash, G; Das, R

    2016-01-01

    The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings.

  7. Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection

    Directory of Open Access Journals (Sweden)

    S Sreedharanunni

    2016-01-01

    Full Text Available The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings.

  8. Disease: H00847 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available (description) Camera G, Ferraiolo G, Leo D, Spaziale A, Pozzolo S Limb/pelvis-hypoplasia/aplasia syndrome (A...Raas-Rothschild (limb/pelvis/uterus-hypoplasia/aplasia) syndrome and WNT7A mutati

  9. Disease: H00846 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00846 Fuhrmann syndrome; Fibular aplasia or hypoplasia, femoral bowing and poly-, ...syn-, and oligodactyly Fuhrmann syndrome is a non-lethal limb malformation disorder with various degrees of limb aplasia/hypoplasia... and joint dysplasia. Major manifestations include hypoplasia of the pelvis, aplasia or hypoplasia...ption) Fuhrmann W, Fuhrmann-Rieger A, de Sousa F Poly-, syn- and oligodactylyl, aplasia or hypoplasia of fibula, hypoplasia

  10. Rational and progress of the phase 3 trial: intensification of the treatment of locally advanced squamous cell carcinoma of the anal canal; Rationnel et deroulement de l'essai de phase 3: localement therapeutique des cancers epidermoides du canal anal localement evolues (FNCLCC/ACCORD 03, FFCD/9802, SFRO)

    Energy Technology Data Exchange (ETDEWEB)

    Peiffert, D. [Centre Alexis-Vautrin, 54 - Vandoeuvre-les-Nancy (France)

    2003-11-01

    Concomitant radiotherapy (5FU -MMC) was proved to be useful in locally advanced anal canal carcinoma. Nevertheless. it remains 30 % of failures after this conservative treatment. The tolerance and efficiency of a neo-adjuvant chemotherapy (5-FU-CDDP) were validated by a phase II trial including 80 patients, which obtained 73 % of colostomy free survival and 70 % of relapse free survival at 3-year follow-up. its usefulness is studied in an ongoing phase III trial, as well as the dose escalation of the boost, from 15 Gy to 25-25 Gy. The results of the 101 first included patients are studied by an intermediate analyze. In July 2003, 222 patients were enrolled by 33 investigating centres out of the 350 planned patients until the end of the trial in December 2004. (author)

  11. Cost evaluation of the enslaved to breathing radiotherapy as part of support program to innovative and expensive therapies; Evaluation du cout de la radiotherapie asservie a la respiration dans le cadre d'un programme de soutien aux therapeutiques innovantes et couteuses

    Energy Technology Data Exchange (ETDEWEB)

    Remonnay, R.; Morelle, M.; Carrere, M.O. [Lyon Univ., 69 (France); GATE, CNRS, UMR 5824, 69 - Ecully (France); ENS LSH, 69 - Lyon (France); Centre Leon-Berard, 69 - Lyon (France); Giraud, P. [Hopital Europeen Georges-Pompidou, Faculte Rene-Descartes, Service d' Oncologie Radiotherapie, Paris V, 75 - Paris (France)

    2009-10-15

    This study had for objective to evaluate the consequences of the implementation of the enslaved breathing on the cost of production of radiotherapy, relatively to the conformal radiotherapy without enslaved breathing (witness group) in the bronchopulmonary cancers and the breast cancers. The tariff aspect was studied. The estimation of the complete cost of the treatment enlighten the inadequacy of the pricing for innovation. (N.C.)

  12. Brain metastases: epidemiological profile and therapeutic results, about a cohort of patients treated in a radiotherapy department in Algiers; Les metastases cerebrales: profil epidemiologique et resultats therapeutiques, a propos d'une serie de patients traites dans un service de radiotherapie a Alger

    Energy Technology Data Exchange (ETDEWEB)

    Chami, S.; Mekki, F. [Service de radiotherapie, hopital d' Alger, Alger (Algeria)

    2010-10-15

    The authors report a retrospective study of the epidemiological profile, clinic characteristics, and mainly palliative therapeutic treatments, more particularly in terms of life quality, and improvement of clinic symptomatology and performance index. This study is based on 38 patients (17 women and 21 men), with a median age of 58.6, and a Karnofsky index greater than 70 per cent. Various data have been collected: brain metastasis number and topography, time interval between cancer diagnosis and metastasis diagnosis, impact on neuro-cognitive function. Survival has been analysed with the Kaplan-Meier method. Short communication

  13. Impact of additional cervical dedicated {sup 18}FDG-PET-CT on the management of head and neck squamous cell carcinoma; Impact therapeutique de l'acquisition cervicale dediee en [{sup 18}F]-FDG-TEP-TDM sur la prise en charge des carcinomes epidermoides de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Queneau, M.; Tourdias, T.; Guyot, M.; Allard, M.; Fernandez, P. [CHU Pellegrin-Tripode, Service de Medecine Nucleaire, 33 - Bordeaux (France); Houliat, H. [CHU Pellegrin-Tripode, Service d' Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale du Pr Bebear, 33 - Bordeaux (France)

    2008-09-15

    Aim of the study: To investigate the therapeutic impact of additional cervical dedicated {sup 18}F.D.G.-PET-CT on the management of head and neck squamous cell carcinoma (H.N.S.C.C.). Materials and methods: Thirty patients with H.N.S.C.C. underwent a [{sup 18}F]-F.D.G.-PET-CT standard, whole-body scan completed by a cervical dedicated protocol. Two physicians blindly reviewed the exams and the results were discussed with surgeons to determine the therapeutic impact of the dedicated protocol. Result: Among 30 patients, only four (13%) discordant results were registered by the both observers, and two more by only one observer (k = 0.75, S.D. = 0.08). As to the four patients: 1) a N0 staged patient on whole body (W.B.) exam was upstaged to N2b in cervical PET (obese patient, whole-body exam with poor quality), 2) for a second patient, no node was described on whole-body scan, but one lymph node in each cervical chain was observed in focused PET, with low standardized uptake value (S.U.V. value), 3) in the other two cases, cervical PET scan upstaged from N2a to N2b and from N2a to N2c (S.U.V. < 3), without any influence on treatment management. Conclusion: Our results show that additional cervical dedicated PET-CT does not modify the management of patients with H.N.S.C.C. when compared to whole-body PET-CT, except for particular obese or N0 patients, allowing to reduce patient CT radiation dose and time-consuming PET acquisition. (authors)

  14. FDG PET/CT in initial staging and early response to chemotherapy assessment of paediatric rhabdomyosarcomas; Apport de la TEP/TDM au {sup 18}FDG dans la stadification initiale et l'evaluation precoce de la reponse therapeutique des rhabdomyosarcomes pediatriques

    Energy Technology Data Exchange (ETDEWEB)

    Eugene, T.; Ansquer, C.; Oudoux, A.; Carlier, T.; Kraeber-Bodere, T.; Bodet-Milin, C. [Services de medecine nucleaire, CHU Hotel Dieu, 44 - Nantes (France); Corradini, N.; Thomas, C. [Services d' oncologie pediatrique, CHU Hotel Dieu, 44 - Nantes (France); Dupas, B. [Service de radiologie, CHU Hotel Dieu, 44 - Nantes (France)

    2010-12-15

    Purpose: The objective of this study was to retrospectively evaluate the impact of positron emission tomography/computed tomography (PET/CT) using fluorine-18-fluorodeoxyglucose (FDG), in comparison with conventional imaging modalities (CIM), for initial staging and early therapy assessment in paediatric rhabdomyosarcoma. Patients and methods: Prior to treatment, 18 patients (age range, 9 months to 18 years) with histologically proven rhabdomyosarcoma underwent FDG PET/CT in addition to CIM (magnetic resonance imaging of primary site, whole body CT and bone scintigraphy). After three courses of chemotherapy, 12 patients underwent FDG PET/CT in addition to CIM. RECIST criteria and visual analysis of FDG uptake were used for assessment of response. The standard of reference was determined by an interdisciplinary tumor board based on imaging material, histopathology and follow-up data (median = 5 years). Results: PET/CT sensitivity was superior to CIM's concerning lymph node involvement (100% versus 83%, respectively) and metastases detection (100% versus 50%, respectively). PET/CT results changed therapeutic management in 11% of cases. After three courses of chemotherapy, the rate of complete response was 66% with PET/CT versus 8% with CIM. Five percent of patients relapsed during follow-up (median = 5 years). Conclusion: This study confirms that PET/CT depicts important additional information in initial staging of paediatric rhabdomyosarcomas and suggests a superior prognostic value of PET/CT in early response to chemotherapy assessment. (authors)

  15. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  16. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  17. Thyroid medullar carcinoma and therapy follow up with the help of PET/T.D.M. with {sup 18}F-DOPA: about four cases; Carcinome medullaire de la thyroide et suivi therapeutique a l'aide de la TEP-TDM a la 18F-DOPA: a propos de quatre cas

    Energy Technology Data Exchange (ETDEWEB)

    Imperiale, A.; Ben-sellem, D.; Keomany, J.; Constantinesco, A. [Biophysique et medecine nucleaire, CHU de Strasbourg, (France); Detour, J.; Beretz, L. [radiopharmacie, CHU de Strasbourg, (France); Chabrier, G.; Goichot, B. [medecine interne et nutrition, CHU de Strasbourg, (France)

    2009-05-15

    The objective was to study the contribution of the PET-T.D.M. to the dihydro phenylalanine labelled with {sup 18}F ({sup 18}F-DOPA) in the therapy follow up of patients with antecedents of thyroid medullar carcinomas and suspicion of biological recurrence. In spite of the very preliminary character of these results, these first cases show the interest of the PET-T.D.M. with {sup 18}F-DOPA in the therapy follow up and the coverage of patients reached by thyroid medullar carcinoma in biological recurrence. (N.C.)

  18. Place of imaging in the evaluation of treatment response in breast cancer;Place de l'imagerie dans l'evaluation de l'efficacite des traitements dans le cancer du sein

    Energy Technology Data Exchange (ETDEWEB)

    Brunotte, F.; Berriolo-Riedinger, A.; Cochet, A.; Toubeau, M.; Dygai-Cochet, I.; Riedinger, J.M. [Centre Georges-Francois-Leclerc, Service de medecine nucleaire, 21 - Dijon (France); Brunotte, F.; Cochet, A. [Universite de Bourgogne, UMR CNRS 5158, laboratoire electronique, informatique et image, 21 - Dijon (France)

    2010-01-15

    This paper describes, from the current literature, the role of various imaging methods to assess the response to therapy in breast cancer. Two different clinical situations are considered: neo-adjuvant chemotherapy of locally advanced breast cancer and the metastatic breast cancer. Significant clinical data are available for three criteria: the volume of the tumour, the uptake of fluorodeoxyglucose using PET and the perfusion of the tumor evaluated either by dynamic contrast-enhanced magnetic resonance imaging (D.C.E.-MRI) or by PET using {sup 15}O water. {sup 18}F F.D.G. PET allows prediction of the response after one or two cycles of neo-adjuvant chemotherapy. New approaches will offer opportunities to refine the role of imaging in monitoring the response to chemotherapy. PET using thymidine as bio marker is promising in assessing the tissular proliferation. Estrogen analogs could be used to predict hormonally responsive breast cancer. Many other approaches, although less developed, might offer new insights in the response to therapy of breast cancer like magnetic resonance spectroscopy or optical imaging of hemoglobin oxygenation. Imaging also offers potential of monitoring the down-regulation of specialized receptors of the cell membrane in response to treatment: the most studied receptor in preclinical model has been the human epidermal growth factor receptor type 2 (HER2). Integrin, a family of cell adhesion receptor, is also an important target for imaging. Apoptosis, multidrug resistance and hypoxia can also be studied using appropriate bio markers. To allow reliable multicenter trials of new drugs, these different imaging approaches still require an improved standardization of image acquisition and processing. (authors)

  19. Assessment of ventilation efficiency for the study of indoor air quality; Appreciation de l'efficacite de la ventilation pour l'etude de la qualite de l'air interieur

    Energy Technology Data Exchange (ETDEWEB)

    Akoua, A.A.

    2004-10-15

    An efficient ventilation system provides a good indoor air quality by eliminating air pollutants and ensuring a satisfactory air renewal. Unlike most research works that deal with test cells with controlled boundary conditions, our study focuses on ventilation efficiency in a real environment. In situ experiments are performed and provide the boundary conditions necessary for CFD (Computational Fluid Dynamics) computations. Using CFD for predicting indoor air quality in a real environment is thus analyzed. The influence of permeability on numerical predictions quality is shown. Unfortunately, it is difficult to quantify accurately the air leakages and their airflow rates. Our study proposes a simplified model that includes air infiltration rates in the CFD computations, and that yields satisfactory results. A critical analysis of ventilation efficiency indices is then performed. It is shown that it is currently impossible to evaluate the air change efficiency ( a e ) in an occupied zone. Concerning the air pollutants removal effectiveness, it is shown that the usual index C e is not suited to ventilation systems with variable airflow rates. For such cases, a new formulation of this index is given. The ratio between the airflow rate and the nominal airflow rate of the ventilation system is also taken into consideration. A coupled analysis of this new index and of this airflow rate ratio enables us to assess the air pollutants removal effectiveness while considering the energetic cost of ventilation. We finally show that there is no universal index. The choice of the index depends on the pollutant, on the pollutant concentration, and on the airflow rate. A tool of decision-making aid is thus proposed in order to evaluate the air pollutants removal effectiveness for various ventilation systems. This tool is flexible and rather simple to use. (author)

  20. Étude des conditions d'efficacité d'une analogie mécanique instrumentée pour l'enseignement de l'électrocinétique en terminale scientifique

    OpenAIRE

    Mercier-Dequidt, Clotilde

    2015-01-01

    For over thirty years, research in didactics of physics have shown in many countries that students encounter learning difficulties in electricity and that, regardless of the grade level. These difficulties can be especially explained by a number of misconceptions that prevent the understanding of electrical phenomena. To overcome these difficulties, researchers in didactics and teachers use analogies which are more or less adapted and powerful. To achieve our research, we study an innovative ...

  1. Standards, options and recommendations for brachytherapy of prostate cancer: efficacy and toxicity; Standards, options et recommandations pour la curietherapie des patients atteints de cancer de la prostate: efficacite et toxicite

    Energy Technology Data Exchange (ETDEWEB)

    Pommier, P. [Centre de Lutte Contre le Cancer Leon-Berard, 69 - Lyon (France); Villers, A. [Centre Hospitalier Universitaire, Hopital Huriez, 59 - Lille (France); Bataillard, A. [Federation Nationale des Centres de Lutte Contre le Cancer, FNCLCC, 75 - Paris (France)] [and others

    2001-12-01

    Context. - The 'Standards, Options and Recommendations' (SOR) collaborative project was initiated in 1993 by the Federation of the French Cancer Centres (FNCLCC), with the 20 French Regional Cancer Centres, several French public university and general hospitals, as well as private clinics and medical specialty societies. Its main objective is the development of serviceable clinical practice guidelines in order to improve the quality of health care and the outcome of cancer patients. The methodology is based on a literature review, followed by a critical appraisal by a multidisciplinary group of experts. Draft guidelines are produced, then validated by specialists in cancer care delivery. Objectives. - Produce technical practice guidelines for the brachytherapy of prostate cancer using the methodology developed by the Standards, Options and Recommendations project. Methods. - The FNCLCC and the French Urology Association (AFU) first designated the multidisciplinary group of experts. Available data were collected by a search of Medline and lists selected by experts in the group. A first draft of the guidelines was written, they validated by independent reviewers. Results. - The main recommendations are: 1/ Brachytherapy with permanent seeds alone is a possible curative treatment for prostate cancer patients with the following prognosis factors: tumour stage T1 or T2a (TNM 1992), Gleason score {<=} 6 and PSA < 10 {mu}g/L. 2/ Combined treatment with brachytherapy and hormonal therapy could be more efficient than brachytherapy alone for prostate cancer patients with Gleason score > 7 and/or PSA > 10. 3/ Combination of brachytherapy and external beam radiation therapy can be proposed to prostate cancer patients with intermediate prognosis. 4/ Before and after seed implantation, risks of infection must be prevented by appropriate antibiotic therapy (recommendation). 5/ Brachytherapy must not be performed within 2 months of trans-urethral prostate resection. 6/The height of the urethra receiving more than 200 of the prescribed dose must be reported. The portion of the rectum receiving 100 and 120 % of the prescribed dose must be limited to 10 and 5 mm length, respectively. (authors)

  2. After Kyoto: equity stakes and efficiency in the negotiation on the climatic change; Au-dela de Kyoto: enjeux d'equite et d'efficacite dans la negociation sur le changement climatique

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, O.; Criqui, P.; Viguier, L. [Institut d' Economie et de Politique de l' Energie - IEPE-CNRS/ Universite Pierre Mendes-France, 38 - Grenoble (France); Trommetter, M. [Institut National de Recherches Agronomiques (INRA), 38 - Grenoble (France)

    2000-07-01

    The first difficulty to get over in the international negotiation on the climatic change, has been and still remain the distribution of the efforts and the research of the equity in the objective determination. This paper aims to show that facing the different interests of each countries, a single rule of differentiation is not possible. The first part is a review of the different charts of the objectives differentiation discussed or proposed in the international negotiation process on the greenhouse effect. It aims to find a bond between the the charts and the equity. The second part proposes the quantification of a scenario of the emission licenses attribution for 2030 for all the world countries. (A.L.B.)

  3. Melanoma vectorized radiotherapy: anti tumoral efficiency of a new marker labelled by iodine 131; Radiotherapie vectorisee du melanome: efficacite antitumorale d'un nouveau vecteur marque par l'Iode 131

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet-Duquennoy, M.; Papon, J.; Miot-Noirault, E.; Madelmont, J.C.; Chezal, J.M.; Moins, N. [EA4231, universite d' Auvergne, Clermont-Ferrand, (France); Mishellany, F.; Cayre, A. [laboratoire d' anatomopathologie, centre Jean-Perrin, Clermont-Ferrand, (France); Maublant, J. [service de medecine nucleaire, centre Jean-Perrin, Clermont-Ferrand, (France); Guerquin-Kern, J.L. [Inserm U759, laboratoire de microscopie ionique, institut Curie, Orsay, (France)

    2009-05-15

    The melanoma is an invasive pathology for which no treatment is efficient on the disseminated form. The works of the Laboratory aim to conceive molecules presenting a specific affinity for the melanoma by targeting the melanin. The aim of this project is to evaluate for the mouse, the anti tumoral effect of vectorized {sup 131}I by the tracer ICF01012 that presents a durable and specific tumor concentration adapted to an application in internal vectorized radiotherapy. Conclusions: A significant anti tumoral effect of the internal vectorized radiotherapy using the compound {sup 131}I-ICF01012 is demonstrated on two models of melanomas whatever their aggressive potential is. This effect is associated to a inhibition of the tumor cells dissemination towards lungs. The optimization of the therapy protocol is running in order to get a maximal therapy efficiency associated to a controlled toxicity of non-targeted pigmented organs. (N.C.)

  4. Ruser sans mentir, de la casuistique aux sciences sociales : le recours à l’équivocité, entre efficacité pragmatique et souci éthique

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Cavaillé

    2010-01-01

    Full Text Available Il s’agit de confronter ici deux domaines qui ne le sont presque jamais : les études contemporaines en sciences sociales sur la communication équivoque et la communication déceptive et les très riches querelles au sujet de la licéité de l’usage des équivoques et des restrictions mentales au début de l’époque moderne qui, à partir de la casuistique, ont investi tous les domaines de l’action. En ces deux domaines, j’envisage la raison rusée dans une perspective où, quel que soit le propos décla...

  5. L'efficacité d'usage énergétique : pour une meilleure gestion de l'énergie électrique intégrant les occupants dans les bâtiments

    OpenAIRE

    Chenailler, Hervé

    2012-01-01

    Energy consumption, particularly electric consumption, in buildings is greatly influenced by the behavior of its occupants. The analysis of the electrical uses thanks to a feedback performed on a test-building platform makes it possible to identify different forms of user satisfaction calling into question the notion of energy efficiency in buildings. In order to take into account the human actors in the design of building systems, it is proposed to define the notion of energy use efficiency ...

  6. L'efficacité d'usage énergétique : pour une meilleure gestion de l'énergie électrique intégrant l'usager dans les bâtiments

    OpenAIRE

    Chenailler, Hervé

    2012-01-01

    Energy consumption, particularly electric consumption, in buildings is greatly influenced by the behavior of its occupants. The analysis of the electrical uses thanks to a feedback performed on a test-building platform makes it possible to identify different forms of user satisfaction calling into question the notion of energy efficiency in buildings. In order to take into account the human actors in the design of building systems, it is proposed to define the notion of energy use efficiency ...

  7. Evaluation de l'efficacité des extraits aqueux de graines de papaye (Carica papaya L. dans le traitement de la coccidiose caecale à Eimeria tenella chez le poulet de chair

    Directory of Open Access Journals (Sweden)

    Akoa Etoa, JM.

    2003-01-01

    Full Text Available Evaluation of the Efficiency of Aqueous Extracts of Papaw Seeds (Carica papaya L. for the Treatment of Caecum Eimeria tenella Coccidiosis in Broiler Chicken. A study was carried out to study the efficiency of aqueous extracts of papaw seeds for the treatment of caecum Eimeria tenella coccidiosis in broiler chicken. Eighty eight 37-day old caged ISA15 VEDETTE broiler chickens were inoculated with a suspension of 3500 ± 1050 E. tenella oocysts/ml. The birds then divided into 4 groups of 22 birds received 10 days later either 0 (D0 dose, 10 (D10 dose, 20 (D20 dose or 40 g/l (D40 dose of aqueous extracts of papaw seeds. Mortality rates of 45.5%, 34.8%, 18.2% and 9.1% were recorded for D0, D10, D20 and D40 groups respectively. As compared to infestation rate before treatment, the reduction rate of the number of oocysts/g of faeces was respectively 6.6%, 42.8%, 73.6% and 91.8% for D0, D10, D20 and D40. Average daily weight gain was 42.7 g, 47.8 g, 69.8 g and 86 g for treatments D0, D10, D20 and D40, respectively while average weekly feed efficiency ratio values of 3.9, 4.1, 2.4 and 1.9 were respectively recorded for D0, D10, D20 and D40 treatments. Aqueous extracts of papaw seeds seemed to be efficient in the treatment of caecum E. tenella coccidiosis in broiler chickens.

  8. Energy efficiency: EDF Optimal Solutions improves the l'Oreal firm of Vichy; Efficacite energetique: EDF Optimal Solutions ameliore l'usine l'Oreal de Vichy

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2011-09-15

    The l'Oreal CAP site has inaugurated its energetic eco-efficiency installations realized by EDF Optimal Solutions. This solution combines several techniques and makes possible to halve its yearly CO{sub 2} releases. (O.M.)

  9. Efficacité du traitement par calcimimétiques dans l'hyperparathyroïdie néonatale sévère, associée à des mutations du calcium sensing receptor (CaSR)

    OpenAIRE

    Wilhelm-Bals, Alexandra Marina

    2013-01-01

    L'Hyperparathyroïdie néonatale sévère (NPHT) est associée à des mutations homozygotes inactivatrices du récepteur du calcium (CaSR). Le CaSR est exprimé majoritairement dans les glandes parathyroïdes et les reins où il régule l'homéostasie du calcium en modulant la sécrétion de PTH et la réabsorption rénale du calcium. L'NPHT se présente avec une hypercalcémie sévère mettant en jeu le pronostic vital. La chirurgie est le traitement de choix. Les bisphosphonates offrent une bonne alternative d...

  10. Mesure de l’efficacité d’identification des électrons et recherche de SUSY dans le canal 2 leptons avec le détecteur ATLAS

    CERN Document Server

    Serre, Thomas

    ATLAS experiment at LHC has, during this three operating years, open access to energy of the order of magnitude of the TeV. In this context, the work has been devoted to the study of the detector performance and the analysis of the data collected. In this thesis, the first part is dedicated to the measure of the electron identification efficiency. Details of the measurement method and first results in two dimensions are presented. The second part shows the search for Supersymmetry in the 2 lepton channel. The full 2012 dataset allows to exclude charginos with a mass lower than 180 GeV in the hypothesis of a massless neutralino.

  11. Energy efficiency in the European Union: overview of policies and good practices; L'efficacite energetique dans l'Union europeenne: panorama des politiques et des bonnes pratiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The world is facing increasing energy prospects and stakes, in terms of energy supply security and safety, environmental impact as well as economic and social costs. In Europe, these fast-growing concerns have led to the adoption of new energy efficiency policies at national and European levels: legislation, regulations, institutional measures, awareness-raising and training campaigns, financial incentives, investment schemes, etc. As in other sectors and at each stage of European development, knowledge and experience feedback drive the Member States towards a growing harmonization of national policies: the most encouraging national measures may be adopted by other countries and even implemented at a European level. The valorization and exchange of best practices therefore contributes to the fulfilment of European commitments on energy efficiency and greenhouse gas emissions reduction. All these schemes are integrally part of a common European energy policy to be applied to energy production, transportation and distribution - the supply side - as well as to all social and economic activities which make up the demand side, and which is the subject of this document. The presentation hereafter provides an overview of energy efficiency policies and programs implemented in the European Union and in the Member States. It shows the diversity of available means of action and strategic choices within the different countries whilst highlighting the most innovative and significant measures. The various tools available are of course used in different ways in each country depending on their characteristics. Economic structure, for example, can explain the differences in the implementation of certain measures as it results in concentrating on the sectors which produce the most greenhouse gases - and which differ from one country to another. Energy balances -energy-producing countries or energy-dependent countries - and political contexts - with more or less liberal governments - can also influence the policy instruments chosen. Comparing national policies requires caution when it comes to detailed comparative analysis. This overview of energy efficiency policies is not exhaustive. In order to best illustrate those policies and present the most meaningful measures, the document distinguishes between the economic sectors, which are prevalent in terms of energy efficiency. This screening leads to the selection of nine themes, each of them corresponding to a chapter: buildings, energy efficient equipments, exemplariness of the public sector, fuel poverty, industry, small and medium enterprises, transportation, agriculture and cross-cutting measures. A first general chapter presents the key figures of European energy efficiency and the policies carried out at the European Union level. In addition to that, eighteen particularly interesting measures will be detailed; those eighteen measures have been selected according to criteria such as energy impact, implementation coherence, financing schemes or valid past evaluation

  12. Contribution to the study of hybrid ventilation system effectiveness in office and educational buildings; Contribution a l'etude de l'efficacite des systemes de ventilation hybride dans les batiments du secteur tertiaire

    Energy Technology Data Exchange (ETDEWEB)

    Cron, F.

    2004-06-15

    This study is part of the International Energy Agency Annex 35, 'Hybrid Ventilation in New and Retro-fitted Office Buildings', also called the HybVent Project. It presents the numerical analyses of a number of hybrid ventilation systems and their potential for several buildings in relation to local climate characteristics. The first part of this work reviews the state-of-the-art of existing ventilation systems and details the principles, expectations and features of hybrid ventilation systems. This first section also examines some examples of hybrid systems extracted from the collection of Annex 35 case studies. A comprehensive bibliography of numerical tools available for this type of analysis is given in the second section. The numerical models for building simulation and the object-oriented environment used to develop our simulation tool are presented in this section as well. Two single-zone studies undertaken in this project are reported in the third section. The first study concerns an experimental cell simulation. Numerical results are compared to experimental data to validate the use of the simulation tool developed. The second single-zone study predicts the potential of a specific hybrid ventilation system in a typical classroom, given climatic conditions. Finally, the last section presents a more complete study - a multi-zone study of the Tonga school, an Annex 35 case study located in Sweden. Three rooms were modelled initially to compare numerical results to experimental data and then to analyse the performance of the existing hybrid ventilation system and two other systems. This final study was completed for three European cities with very different climates. The overall analysis of the potential of the hybrid ventilation systems considered and the perspective for future work are outlined in the conclusion. (author)

  13. The economical impact and the environmental efficiency of the ISO 14001/EMAS certification of industrial companies; L'impact economique et l'efficacite environnementale de la certification ISO 14001/EMAS des entreprises industrielles

    Energy Technology Data Exchange (ETDEWEB)

    Backer, P. de

    1999-07-01

    The 1836/93 EMAS is the European regulation on environmental management and auditing scheme. Its aim is to answer the precise requirements of a standard for the management of the environmental impacts of industrial activities. The ISO 14001 standard defines the requirements of an environmental management policy at the international scale. The aim of this study is to make a statement of the enforcement of the ISO 14001 and EMAS environmental management systems in France in terms of results and with respect to the help provided by public authorities. The following aspects are analyzed successively: the aim of the study (context, global goal, hypotheses, cost-benefit analysis, qualitative appraisal); the methodological aspects (selection of sites, sectoral distribution, geographical, legal and financial aspects, data collection, analysis and synthesis); the motivation of companies (sectoral analysis, business aspects, reduction of operation costs, personnel motivation); the objectives of the environmental management system (conformability analysis, environmental goals, effluents, soil pollution, energy and water conservation, wastes, consumption of raw materials, noise and other pollutants); economical aspects (cost, personnel training, audits, benefits, minimization of environmental impacts, reduction of energy, water and materials consumption); cost-benefit evaluation; environmental efficiency of the environmental management system; attitude of other companies; comparison with other European countries; synthesis and proposals. (J.S.)

  14. Les aliments issus de plantes génétiquement modifiées : équivalence, efficacité et sécurité chez les animaux de la ferme

    OpenAIRE

    2002-01-01

    On affirme, même sans preuve avérée, que les aliments issus de la transformation génétique des plantes présentent des risques pour l’homme et les animaux. On reconnaît seulement les avantages agronomiques des plantes génétiquement modifiées (GM) ayant fait l’objet d’une autorisation de dissémination. L’équivalence en substance (composition chimique), la sécurité et l’innocuité ont pourtant été vérifiées préalablement à leur autorisation. C’est seulement récemment que l’on a démontré chez les ...

  15. Optimizing the efficiency of a diesel engine for a hybrid wind-diesel experimental validation; Optimisation de l'efficacite du moteur diesel pour un systeme hybride eolien-diesel-validation experimentale

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, H.; Dimitrova, M. [TechnoCentre Eolien, Murdochville, PQ (Canada); Ilinca, A. [Quebec Univ., Rimouski, PQ (Canada); Perron, J. [Quebec Univ., Chicoutimi, PQ (Canada)

    2010-07-01

    This study examined the feasibility of using a wind-diesel compressed air storage system in large-scale gas turbines at remote sites where a good wind resource is available. Studies have shown that the system can increase the wind energy penetration rate, particularly when combined with a turbo diesel engine. The system increases the power and performance of the diesel engine and reduces fuel consumption and emissions of greenhouse gases greenhouse gases (GHG). This study included a comparison of different technical solutions for the compressed air energy storage system, and described the one that optimized the performance and cost of the overall system. The optimal solution allowed the turbocharger to operate independently of the engine due to the energy provided by the compressed air in the air turbine. Optimization required maximizing the compressor power as an objective function. The energy balance of the engine itself had to be taken into account, along with the turbo charging system. 12 refs., 2 tabs., 16 figs.

  16. Réponses agro-physiologiques et efficacité d'utilisation de l'eau chez le maïs (Zea mays L. - cv. Synthetic-C soumis au déficit hydrique

    Directory of Open Access Journals (Sweden)

    Diouf, M.

    2001-01-01

    Full Text Available Agrophysiological Responses and Water Use Efficiency of Maize (Zea mays L. - cv. Synthetic-C in Water Deficit Conditions. Senegal is known to have very tow rainfall with high probability of drought occurring du ring crop development. The study on the growth of maize under water deficit conditions aimed at characterising its agro-physiological responses and the evaluation of its water use efficiency (WUE. A water deficit was applied respectively during the vegetative phase (T1, at flowering start (T3 and both during the vegetative phase and at flowering start (T2 with a period of rewatering between these two phases. For the control (TO water was applied by irrigation to maintain optimal water conditions for growth. The amount of water to complete (in low rainfall conditions during the cycle was determined by measuring "bac" evapotranspiration and using crop coefficient (Kc for maize during the different phases. The results show that Synthetic-C variety was sensitive to water deficit during the flowering phase. Actually, the relative water content (RWC, leaf water potential and crop water stress index (CWSI were less sensitive to water deficit during the flowering phase than during the vegetative phase. These parameters showed a higher rate of decrease during the vegetative phase. On the other hand, gazeous exchanges [stomatal conductance (Gs and transpiration (Tr] were found to be more sensitive to water deficit during the reproductive stage. Moreover, significantly low grain yield and WUE were observed during this phase of development. However, on the basis of physiological parameters and productivity, Synthetic-C showed a good capacity to resume its physiological activities after rewatering during the vegetative phase, similar to a good plasticity of the control.

  17. Sentiment d’auto-efficacité des enseignant-e-s au travers… des émotions !: Du côté des états physiologiques et émotionnels

    OpenAIRE

    Chervet, Anne; Jordan, Aurélie; Puozzo Capron, Isabelle

    2016-01-01

    Les émotions ont été observées au fil du temps, particulièrement depuis le 19e siècle (Damasio, 2010/2010 ; Reeve, 2012 ; Vygotski, 2003 ; Wood et al., 2009). Il s’agit d’un concept difficile à définir (Audigier, 2004 ; Reeve, 2012 ; Ria, 2005), car il peut être considéré du point de vue biologique, psychologique, des neurosciences, etc. Une émotion est un état affectif soudain, intense et de courte durée, activé physiologiquement, exprimé corporellement et qui active des processus mentaux (W...

  18. Nouvelle technique d'élevage de l'acarien phyllophage Tetranychus urticae Koch (Acari : Tetranychidae et son application à l'étude de l'efficacité de quelques acaricides sur pomme de terre (Solarium tuberosum L.

    Directory of Open Access Journals (Sweden)

    Badegana, AM.

    2000-01-01

    Full Text Available A New Rearing Technique of Phytophagous Mite Tetranychus urticae Koch (Acari : Tetranychida and its Application in the Study of the Efficacy of some Acaricides on Potato [Solanum tuberosum L.. A 5 cm diameter leaf disc of potato or another host plant (or four on 2.5 cm diameter was used in a Petri dish of 9 cm diameter for the rearing technique. This leaf disc, pierced in its centre, slides along a rustproof pin and floats on a 1 mm thick lamina of demineralized fresh water. Water is a "strong barrier" which confines the tetranychid mites on the leaf disc, even if this one does not corne from a host plant (tetranychid mites deprived of food. This rearing technique was used as a bioassay to test the effectiveness of acaricides (pyrimiphos-methyl, bromopropylate, fenpropathrin, dienochlor on the developmental stages of Tetranychus urticae. The ovicidal activity against the eggs of one, three, seven days old (the eggs incubation duration being 8.1 ±0.15 days was also studied. The results obtained show that bromopropylate, fenpropathrin and dienochlor have an ovicidal activity against the eggs of the different ages, but dienochlor has the highest efficiency (90 % mortality. Pyrimiphos-methyl is only active against the seven-day old eggs and bromopropylate has a high efficiency only on the one-day old eggs. Concerning the other developmental stages such as chrysalis (protochrysalis, deu-tochrysalis, teleiochrysalis and mobile stages (larva, protonymph, deutonymph and adult female, pyrimiphos-methyl has de highest efficiency (90 % mortality ; dienochlor also, except mobile stages. Bromopropylate has no activity against the chrysalis and mobile stages and fenpropathrin has a remarkable repulsive effect.

  19. Efficacité de la roche phosphatée de Matongo au travers d'un compostage sur une culture de pomme de terre sur un sol acide de Rabiro (Burundi

    Directory of Open Access Journals (Sweden)

    Van den Berghe, C.

    1993-01-01

    Full Text Available Efficiency of phosphatic rock from Matongo applied in the composting process on potatoes on an acid soil of Rabiro. In the frame of the Cooperation between the CVHA (Cultures Vivrieres de Haute Altitute Project and the Program of Fertilisation of the Agro-systems on Altitude (FAVA of the Faculty of Agricultural Sciences in Burundi, the local phosphatic rock from Matongo has been compared to diammonium-phosphate when added in the composting process. The field trials with potatoes have shown that both phosphate sources have the same fertilizing value when the enriched compost was applied at the dose of 20 t/ha. It is very interesting from agricultural and economical viewpoint to use this phosphatic rock in combination with compost.

  20. Fission product removal by containment spray - influence of the distance between the drops on the aerosol collection efficiency; Influence de la densite spatiale des gouttes d'aspersion sur l'efficacite de collecte des produits de fission

    Energy Technology Data Exchange (ETDEWEB)

    Gauchet, N

    2000-07-01

    This work is within the framework of the studies that are conducted at the IPSN concerning the loss of coolant in a nuclear reactor. During this kind of accident, a spray system in the reactor containment induces the scrubbing of fission products in the atmosphere, and allows the decrease of their concentration in the containment. Our objective is to study the influence of the distance between the drops of their aerosol collection efficiency. This is not taken into account in the existing models. We stimulate the various aerosol collection mechanisms with one free falling drop using computational fluid dynamics codes. The mechanisms are: deposition by brownian diffusion, impaction and interception of the particles by the drop, and collection of particles in the presence of steam condensation at the surface of the drop. These phenomena are studied for drops ranging in diameter from 100 to 700 micrometers, falling in a saturated air-steam mixture whose temperature varies between 20 and 140 degrees Celsius, and total pressure varies between 1 and 5 bars. We validate these models with results available in the literature and with experimental results CARAIDAS. Then we apply these models to the case of three aligned drops, which constitutes a case for which the proximity of the drops has a strong influence on the collection of aerosols. While varying the distance between the drop from 5 to 25 drop diameters, we can highlight the modification of the collection efficiency of each mechanism related to the disturbance of the velocity and concentration fields in the vicinity of the drops. We note that the strongest variations of efficiency observed are in the field of impaction, and that the steam condensation at the surface of the drops limits the decrease. (authors)

  1. Étude de l'efficacité des modes de Lamb dans la signature acoustique V(z) d'une couche mince par la théorie de la résonance

    Science.gov (United States)

    Ramdani, Abderrafi; Augereau, Franck; Despaux, Gilles

    1996-05-01

    Experimental acoustic signatures measured on thin films are perturbated by an interference process between the different Lamb waves generated at various incident angular values. This disables the correct determination of the layer's acoustic parameters and for this reason, it is helpful to develop a powerful method to study the influence of each layer parameter on these modes. For this purpose, a technique based on the calculation of the half-height width on resonance peaks of the reflectance power has been elaborated. From these simulations, we may determine which modes will be more efficiently extracted from acoustic signatures for steel and glass films. This result has been confirmed experimentally using ultrasonic frequencies optimized versus the sample thicknesses for glass and steel plates. Indeed, from experimental acoustic signatures, we have next been able to retrieve the acoustic parameters of these samples. Les relevés expérimentaux des signatures acoustiques sur des couches minces sont difficiles à interpréter car tous les modes de Lamb générés à differents angles d'incidence vont interférer, ce qui rend impossible toute détermination des paramètres acoustiques de la couche. Il est alors nécessaire de mettre en oeuvre une méthode d'analyse rapide afin d'étudier l'influence de chacun des paramètres de la couche sur ces modes afin de déterminer les conditions optimales de mesure. La méthode d'analyse basée sur la détermination de la largeur à mi-hauteur des pics de résonance du pouvoir réflecteur est un moyen original de résolution du problème direct, qui permet de montrer que certains modes sont plus efficaces que d'autres, et donc plus faciles à détecter sur les signatures expérimentales. Grâce aux résulats théoriques obtenus, les fréquences d'observation ont pu être optimisées pour des épaisseurs de plaques d'acier et de verre utilisées dans la partie expérimentale de ce travail. De ces mesures et en utilisant notre modèle de simulation de la signature acoustique, nous avons résolu le problème inverse et ainsi avons pu déterminer les paramètres acoustiques de ces couches.

  2. Etude sur l'efficacité de dispositifs amortisseurs à base d'AMF, pour atténuer la vibration de câbles : méthodologie de traitement et analyse de données

    OpenAIRE

    HELBERT, Guillaume; INSTITUT FRANCAIS DES SCIENCES ET TECHNOLOGIES DES TRANSPORTS, DE L'AMENAGEMENT ET DES RESEAUX - IFSTTAR; ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET D'AEROTECHNIQUE DE POITIERS - ENSMA

    2011-01-01

    Les câbles de pont, qui permettent d'assurer la tenue mécanique des ouvrages d'art, sont confrontés à des sollicitations extérieures conduisant à leur mise en vibration et donc à un potentiel phénomène de fatigue. L'unité de recherche SMC travaille sur le développement d'un amortisseur à base d'alliages à mémoire de forme, pour ces câbles, afin augmenter leur durabilité. Des essais, réalisés en 2010, consistent à mettre un câble en vibration et à étudier son déplacement en présence ou non du ...

  3. Efficacité de quelques séquences d’herbicides contre les mauvaises herbes du pois chiche et de la féverole conduits en semis direct

    Directory of Open Access Journals (Sweden)

    Badr HAJJAJ

    2016-12-01

    Full Text Available In order to evaluate the efficacy of 18 sequences of pre and post emergence herbicides on weeds of no till faba bean and chickpea and their impact on crops grain yield, two trials were conducted during 2014-2015 growing season at Sidi El Aidi INRA research station and at a farmer’s farm in Ouled Said (Settat. Dominant species of weed flora in chickpea in Sidi El Aidi were: Bromus rigidus, Lolium rigidum, Avena sterilis, Cichorium endivia, Centaurea diluta, Emex spinosa and Papaver rhoeas. Dominant species of weed flora in faba bean at Ouled Said were: Avena sterilis, Plantago afra, Chrysanthemum coronarium, Centaurea diluta, Sonchus oleraceus and Silybum marianum. The obtained results showed that herbicides react differently on weed and crops. Treatments which showed good weed control and better selectivity provided the best crop yield. “Pendimethalin (1258,5 g/ha + Bentazon (960 g/ha” and “Acetochlor (2100 g/ha + Bentazon (960 g/ha” provided good weed control and good selectivity in horse bean crop. “Pendimethalin (1258,5 g/ha + Bentazon (960 g/ha” needs to be more tested on chickpea before its recommendation on this crop.

  4. Efficacité de la synchronisation des chaleurs et insémination artificielle chez le bovin Azawak: intérêt du profil de progestérone

    Directory of Open Access Journals (Sweden)

    Marichatou, H.

    2010-01-01

    Full Text Available Efficiency of Estrous Synchronization and Artificial Insemination in Azawak Cows: Interest of the Progesterone Profile. For a few years, the sperm of selected Azawak bull has been used in artificial insemination (AI on the local bovine races of Niger, to improve the potential of production. Two methods of estrous and ovulation synchronization are compared: vaginal spirals PRID (Progesterone Vaginal Intra Device and intra muscular injection of GnRH (Gonadotropin Releasing Hormon. For this purpose, seven and six Azawak Females were successively used by treatment. AI were carried out twice at 56 h and 68 h for the PRID, and 20 h and 44 h for the GnRH, after stop of the treatment. Heats appearance was controlled by direct observation during the 7 days following the end of the treatment. Blood were carried out for ten females (5 of each batch three times per day from J9 to J16, then once daily until J27, and finally at twice-weekly intervals during the 5 weeks which followed, in order to establish a profile of plasmatic progesterone by animal. In addition, a pregnant diagnosis was carried out per transrectal palpation, three months after AI. For each of the two treatments, three females expressed estrus, including two before the first AI, and the third later (1 and 5 days respectively for the PRID and GnRH. The increase of plasmatic progesterone rate of these two cows, occurred in the two days after the first AI, with a pregnant on both for the PRID, and two for GnRH. The three whose heats were not noted, were not pregnant in both cases, and had an increase in the plasmatic progesterone rate 3 and 8 days after the first AI respectively for the PRID and GnRH. In conclusion, we did not observe a difference in the answers of two treatments. Moreover, the females without estrus observed, were showed a normal cycle (by the progesterone profile but with late ovulations that have not allowed fecundation. These results suggest us once more, to make the first IA as of the appearance of heats, and in addition, to inseminate only on heats observed.

  5. Efficacité de la technique d'induction florale d'Ananas comosus (L. Merr. au moyen de charbon actif enrichi à l'éthylène (TIFBio

    Directory of Open Access Journals (Sweden)

    Lebeau F.

    2009-01-01

    Full Text Available Efficiency of the Ananas comosus (L. Merr. flower induction treatment based on ethylene enriched activated carbon (TIFBio. Pineapple is an important export crop for tropical countries. The flower induction treatments are essential to the pineapple production for economical and social reasons. For conventional agriculture, many chemicals are available but for organic farming ethylene is the only allowed product. A new flower induction method suited to small organic growers has been developed by the Pesticides Initiative Programme of the Coleacp funded by the European Development Fund. The trials conducted proved that the method reaches more than 80% efficiency at 10 weeks for the different application methods evaluated. The wet application trials show a doses response effect as well as effect of the application replication at 2 days interval. The flowering rate culminates at 100% after 8 weeks for the best results, obtained with the wet treatment at 250 mg per plant applied two times at 2 days interval. The different dry treatments tested gave all 85 – 90% flowering rates at 10 weeks, suggesting the presence of an undetermined limitation factor in the conditions prevailing for the trial. The time of application during the day shows no significant effect. It is concluded that the growers can use the TIFBio technique for production control. It is recommended to evaluate the most suited application technique according to their particular case as environmental effect can affect the efficiency.

  6. Une verification de l'efficacite de la methode verbo-tonale: apprentissage du /y/ francais par des americanophones (Testing of the Efficiency of the Verbo-Tonal Method: The learning of the French /y/ by Speakers of American English)

    Science.gov (United States)

    Fort, Paul; And Others

    1976-01-01

    This article describes a study designed to test the basic notions of the verbo-tonal method of error correction in second language learning, a method based on an awareness of the phonological system of the speaker's native language and its influence on the phonological system of the target language. (Text is in French.) (CLK)

  7. A new experimental approach for the measurement of the efficiency of fiber filters under low pressure; Une nouvelle approche experimentale de la mesure de l`efficacite des filtres a fibres a basse pression

    Energy Technology Data Exchange (ETDEWEB)

    Attoui, M.

    1995-12-31

    Theoretically, the permeance of a fibrous filter decreases with falling pressure. However, few experimental studies have been drawn to verify this theory. Our work has objectively measured the permeance of a fibrous filter to pressures in order of 10 hPa (1 kPa), such that comparisons could be made with the theoretical results. After a literature search of existing knowledge on filtration, we adapted the most advanced theoretical model, the model of S. Payet, for the low-end pressures. Secondly, we developed an original method of experimental measurements for the permeance of a filter, allowing us to twist around the problems associated with aerosol metrology at the lower end pressures. To this effect, we realised a form of tests to completely adapt to these problems. We validated our method by comparing these results to those given by the classic method under atmospheric pressure. Finally, it was possible for us to show the reduction of permeance (and thus the increase of the efficiency) of `formettes` filters for 6 diameters of DOP aerosols, from 4 10-2 {mu} to 0.3 {mu}m, and for filtration velocities between 2 and 40 cm/s. We showed that our experimental results agreed well, according to our theory, up until 50 hPa (5 kPa). (author). 119 refs., 39 figs., 5 appends.

  8. Military Command Team Effectiveness: Model and Instrument for Assessment and Improvement (L’efficacite des Equipes de Commandement Militaires: un Modele et un Instrument Pour L’evaluation et L’amelioration)

    Science.gov (United States)

    2005-04-01

    8, Boulevard Victor F-00303 Armées – France Panel Executive Col. Carel E.M. BANSE, MA BP 25 92201 Neuilly-sur-Seine – France Tel: +33 1 55...The model of Vroom and Yetton (1973) deals with the problem of leaders making decisions in different situations. A participative approach of...design, (c) mission clarity, (d) autonomy, (e) rewards, (f) performance feedback, (g) training/consultation, and ( h ) physical environment. Janz

  9. Clinical, histological and histochemical efficiency of Biafin on the skin effects of the external cervical radiotherapy; Efficacite clinique, histologique et histochimique de la biafine sur les effets cutanes de la radiotherapie externe cervicale

    Energy Technology Data Exchange (ETDEWEB)

    Nizri, D.; Boisnic, S.; Benslama, L.; Branchet, C.; Bervialle, C. [Groupe de la Pitie-Salpetriere, 75 - Paris (France); Cassam-Chenai, A.; Bergogne, F. [MEDIX, 78 - Houdan (France); Kappler, M. [UMANIS, 92 - Levallois-Perret (France); Atlan, D. [Johnson et Johnson Janssen, 92 - Issy-Les-Moulineaux (France)

    2006-11-15

    The Biafin is an efficient complement of prevention for erythema during and after the radiotherapy of cancers of superior aero digestive tracts but also on the dryness and skin elasticity and on the histological level with vasodilation reduction and endothelial regeneration. (N.C.)

  10. Fluid Displacement Efficiency in Layered Porous Media. Mobility Ratio Influence Efficacité de déplacement de fluides en milieu poreux stratifié. Influence du rapport de mobilité

    Directory of Open Access Journals (Sweden)

    Wright R. J.

    2006-11-01

    Full Text Available Important effects of petroleum reservoir stratification upon chemical enhanced oil recovery processes have been modelled using systems containing layers of two different permeabilities. Experimentally, visual models composed of glass bead packings have been exploited and miscible matched-density displacements performed. The results show a strong sensitivity to fluid mobility ratio. Flow pattern observation and mathematical analysis have shown that complex viscous crossflow processes are very influential. We present a non-empirical mathematical model for dual layer systems. Our calculation of crossflow effects using this analytical method compares favourably with experimental results from varions sources. Finally, we show how to apply this model to multilayer cross-sectional and three-dimensional problems. Des effets majeurs de la stratification de réservoirs pétroliers sur les procédés chimiques de récupération assistée du pétrole ont été modélisés au moyen de systèmes comprenant des couches à deux perméabilités différentes. Pour l'approche expérimentale, nous avons eu recours à des modèles d'observation composés de billes de verre où des déplacements de fluides miscibles de densités ajustées ont été réalisés. Les résultats indiquent une forte sensibilité au rapport de mobilité des fluides. L'observation du schéma d'écoulement et son analyse mathématique ont montré que des phénomènes d'écoulement visqueux interbancs ont une très grande influence. Nous présentons un modèle mathématique non empirique de systèmes à double couche. Nos calculs des effets des écoulements transversaux avec des méthodes analytiques sont bien vérifiés par les résultats expérimentaux provenant de sources diverses. Nous montrons enfin comment appliquer ce modèle à des problèmes à plusieurs bancs avec échanges entre couches et à trois dimensions.

  11. Quel est l'impact des registres sémiotiques sur l'efficacité d'une séquence d'enseignement sur les gaz pour des élèves de Seconde ?

    OpenAIRE

    Givry, Damien; Delserieys, Alice

    2013-01-01

    This research be interested in written language and sign systems in learning scientific concepts. It will show that the effectiveness of teaching about the gas on students varies with semiotic registers, as text or diagram. Our theoretical framework is in physics education and adopts a socio-constructivist approach using work on the semiotic. Based on a pre and post test (using text and diagram) given to 90 students at the upper-secondary school level (Grade 10 [15-year-old students]), we ana...

  12. Efficacité comparée de deux méthodes de maîtrise de la reproduction de la brebis Djalonké, variété 'Mossi'

    Directory of Open Access Journals (Sweden)

    Boly, H.

    2000-01-01

    Full Text Available Estrous Synchronisation in Djalonke, var. 'Mossi' Ewes : Comparison of Hormonal Treatment and Ram Effect. Zootechnical (ram effect and hormonal (Fluoro Gestone Acetate or FGA, and Pregnant Mare Serum Gonodotropin or PMSG methods on estrous and parturition synchronisation were tested on 24 Djalonke var. 'Mossi' ewes. The use of ram jumping combined with plasma progesterone assay showed that the zootechnical method using male effect provides better estrous synchronisation (4.8 + 2.2 days for estrous delay and better gathering of parturition (within 8 days. The hormonal method by FGA + PMSG provide good estrous synchronisation (3.1 + 20days but lead to a weak lam-bing gathering (within 21 days. After hormonal induction of estrous, a lower fertility was observed and seems to be related to the doses of FGA and PMSG with were relatively high for these small format of Djalonke var. 'Mossi' breed.

  13. Strategy and development means of the energy efficiency and renewable energies sources in France; Strategie et moyens de developpement de l'efficacite energetique et des sources d'energies renouvelables en France

    Energy Technology Data Exchange (ETDEWEB)

    Cochet, Y.

    2000-09-01

    In the framework of the renewable energies development policy and the energy mastership wanted by the Government, a document has been asked by the Prime Minister. It evaluates the development prospects at long and medium dated, of the main chains of renewable energies production taking into account the national developable deposits size, the technologies assessment, the environmental impacts and the competition facing the traditional energies. It evaluates the measures leading to an increasing efficiency. Measures concerning the regulations, the budget, and the fiscality are also discussed. From these analysis, a national strategy for actions in favor the renewable energies, are proposed. (A.L.B.)

  14. Efficacité des huiles essentielles d'Eucalyptus camaldulensis et de Cymbopogon citratus dans la protection des stocks de riz contre Sitophilus oryzae (Coleoptera: Curculionidae) et Sitotroga cerealella (Lepidoptera: Gelechiidae)

    OpenAIRE

    Togola, A.; Silvie, Pierre; Seck, P.A.; Menozzi, P.; Nwilene, F. E.; Glitho, I.A.; Chougourou, D.

    2014-01-01

    L'augmentation de la production rizicole en Afrique Subsaharienne et la recrudescence conséquente des ravageurs de stocks tels que Sitophilus oryzae et Sitotroga cerealella nécessitent des actions d'accompagnement de la recherche afin de préserver la qualité et la quantité des récoltes entreposées. Les méthodes de lutte les plus largement utilisées en milieu paysan dans le cadre de la protection des stocks sont les méthodes chimiques. Il apparaît nécessaire de développer de nouvelles mesures ...

  15. Effet du mode de conservation de l'huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L. Walp. au Niger

    Directory of Open Access Journals (Sweden)

    Abdoul Habou, Z.

    2014-01-01

    Full Text Available Influence of the Conservation Mode of Jatropha curcas L. oil on its Efficacy in the Control of Major Insect Pests of Cowpea (Vigna unguiculata (L. Walp in Niger. Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to light and the other kept in the dark. The insecticidal efficacy was evaluated in a field with three concentrations (5, 10 and 15% trial on the main pests of Cowpea (Vigna unguiculata (L. Walp and in a laboratory test on Megalurothrips sjostedti Trybon (Thysanoptera: Thripidae with different concentrations of crude oil (50; 100; 150 and 200 µl. No difference in insecticidal effect was found between the two modes of oil conservation, both in the laboratory and in the field. In the field, regardless of the mode of conservation, the concentrations of 10% of J. curcas oil enables a reduction of over than 80% of thrips, aphids, and bugs compared to the control. Its increased seeds yield more than 50%. The concentration of 15% gives an insecticidal effect comparable to that of the reference treatment (deltaméthrine but induces phytotoxicity symptoms on the leaves of Cowpea.

  16. Células tronco imaturas de polpa dentária humana: uma nova estratégia terapêutica para o tratamento da aplasia de medula óssea em modelo animal.

    OpenAIRE

    Vivian Fonseca Gonzaga

    2016-01-01

    AA é uma doença grave caracterizada por pancitopenia e hipocelularidade medular, que pode levar a morte. Em casos severos os tratamentos são restritos ao transplante alogênico de MO e/ou uso de imunossupressores. Para isso, deve ser tipado o HLA entre doador e beneficiário. Com isso, as CTM são fontes celulares candidatas para este propósito, pois são praticamente não imunogênicas devido à sua ação parácrina de imunomodulação. Além disso, as CTM possuem um importante papel na hematopoiese. Pa...

  17. A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)

  18. Interaction entre différentes souches de Rhizobium lupini et les espèces ou cultivars de lupin (Lupinus albus, Lupinus luteus et Lupinus mutabilis)

    OpenAIRE

    LAGACHERIE, Bernard; Bours, Michele; Giraud, J Jacques; SOMMER, Georges

    1983-01-01

    L’efficacité fixatrice de souches de Rhizobium lupini a été mesurée en serre sur Lupinus albus, luteus et mutabilis. De fortes interactions se manifestent : 86 p. 100 des souches testées ont une bonne efficacité sur L. albus, 52 p. 100 sur L. mutabilis et 40 p. 100 sur L. luteus ; 22 p. 100 des souches ont une bonne efficacité fixatrice sur les trois espèces. Les interactions observées en serre se conservent au champ où les souches fixatrices augmentent le rendement en grain et la teneur ...

  19. Adjuvant irradiation in breast cancer patients with A.T.M. gene heterozygous mutations: Special focus on clinical efficacy/toxicity; Toxicite et efficacite de la radiotherapie adjuvante chez les patientes traitees pour un cancer du sein et porteuses d'une mutation heterozygote du gene de l'ataxie-telangiectasie

    Energy Technology Data Exchange (ETDEWEB)

    Chargari, C.; Kirova, Y.M.; Even, C.; Monnier, L.; Dendale, R.; Campana, F.; Fourquet, A. [institut Curie, Dept. de Radiotherapie, 75 - Paris (France); Chargari, C. [Hopital d' Instruction des Armees du Val-de-Grace, Service d' Oncologie Radiotherapie, 75 - Paris (France)

    2009-06-15

    Dysfunction of the ataxia telangiectasia mutated (A.T.M.) gene has been related to defective cell cycle control and genomic instability due to the impaired repair of DNA double strand breaks. Although increased radiosensitivity in A.T.M. heterozygous patients has been suggested in preclinical data, clinical implication of A.T.M. variant remains debated. Despite frequent in vitro hypersensitivity in patients with severe radiation-induced delayed toxicity, heterozygoty for A.T.M. gene does not represent the major cause of unexpected complications after radiation therapy. This might be partially due to potential coexistence of alterations in additional genes that would play a role in development of late radiation-induced adverse response. Although several data suggest that some A.T.M. polymorphisms would increase grade 3 subcutaneous fibrosis at lower doses compared with patients who did not possess these genetic alterations, the relationship between the presence of A.T.M. mutations or sequence variants and radiation-induced toxicity remains controversial in part because of their biological and functional significance. Considering the lack of prospective data, patients with A.T.M. mutation should be considered as candidates for both dose volume and dose reduction clinical trials. (authors)

  20. Etude technico‐économique de l'efficacité énergétique de l'aérogare passagers de l'aéroport de Lesquin : Gestion des consommations énergétiques et analyse thermique du bâtiment

    OpenAIRE

    Duch Parera, Ivette

    2008-01-01

    Ce projet fin d’étude est une partie du projet Solairport, qui est un programme de recherche au niveau du laboratoire énergétique de l’ENSAM Lille en accord avec le département du Nord et l’aéroport de Lille‐Lesquin. Il s’agit d’implanter 100.000 m² de panneaux photovoltaïques afin de couvrir en partie les besoins d’électricité de l’aéroport. En parallèle, il a été décidé de mener une étude sur les aspects consommations de chauffage. Le présent projet s’inscrit dans ce cadre. ...

  1. CTEF 2.0 - Assessment and Improvement of Command Team Effectiveness: Verification of Model and Instrument (CTEF 2.0 - Diagnostic et Amelioration de l’Efficacite d’un Team de Commandement: Verification du Modele et de l’Instrument)

    Science.gov (United States)

    2010-09-01

    regression technique specified by Baron and Kenny (1986). In the first step, the relationship is assessed between the predictor and criterion (i.e., X Y...PA: AMOS Development Corporation. [2] Baron , R.M. and Kenny , D.A. (1986), The moderator-mediator variable distinction in social- psychological...operational staff, with multiple teams and dynamic sub-groups, is appealing. This might require an additional development of CTEF which is beyond our

  2. Efficiency of the metabolic radiotherapy with {sup 177}Lu Octreotate in the case of gastric endocrine tumor with hepatic metastases; Efficacite de la radiotherapie metabolique au{sup 177}Lu Octreotate dans le cas d'une tumeur endocrine gastrique avec metastases hepatiques

    Energy Technology Data Exchange (ETDEWEB)

    Leghzali Moise, H.; Besse, H.; Stievenart, J.L [Medecine nucleaire, hopital Beaujon, AP-HP, (France); Scigliano, S. [service hospitalier Frederic-Joliot, Orsay, (France); Mortazavi Jehannod, N.; Lebtahid, R.; Le Guludec, D. [medecine nucleaire, hopital Bichat, AP-HP, (France); Ruszniewski, P. [pancreato-gastroenterologie, hopital Beaujon, AP-HP, (France)

    2009-05-15

    The therapy means of evolved, metastases or inoperable forms of digestive endocrine tumors are limited. we illustrate a case of treatment efficiency by {sup 177}Lu-Octreotate of a well differentiated gastric endocrine tumor with hepatic metastases. conclusions: the metabolic radiotherapy of endocrine tumors constitute a new alternative of conventional treatments, showing the achievement of objective tumor responses at advanced stages, and in failure of conventional treatments. it is necessary to identify the predictive factors of the therapy response in order to optimize the results and to limit the toxicity. (N.C.)

  3. Relationship Between Chemical Structure and Effectiveness of Some Metallic Dialkyl and Diaryldithiophosphates in Different Lubricated Mechanisms Relations entre la structure chimique et l'efficacité de quelques dialkyles et dialkylaryldithiophosphates métalliques dans différents mécanismes lubrifiés

    Directory of Open Access Journals (Sweden)

    Born M.

    2006-11-01

    Full Text Available The antiwear (AW and extreme-pressure (EP properties of some metallic dialkyl and diaryidithiophosphates (MDTP, including zinc, have been studied in different metal/metal contact conditions : four-ball and FZG rigs. We have noted :- With pure dialkyldithiophosphates of different divalent metals (Zn, Cd, Cu, Pb, Ni, Co, prepared from the same alcohol :(a On the four-ball rig, EP results, expressed in terms of load-wear index, show that the highest performances are obtained with ZnDTP, but statistically the higher the ionic radius of the metal, the better the performance. EP results, expressed in terms of weld load, do not show any difference between these MDTP. (b On the four-ball rig, AW results, expressed in terms of wear scar, show that the highest performances are obtaine with ZnDTP; beyond a certain value these performances with Zn and Pb are almost independent of the concentration. For the other metallic DTP, there is a very close relationship between performance and concentration. (c On the FZG gear rig, EP-AW results, expressed in terms of failure load stage and specific wear, show that statistically, the higher the ionic radius of the metal, the better the performance. - With ZnDTP :(a On the four-ball rig, EP results, expressed in terms of load wear index, do not depend on the chemical structure of the alcohol used for synthetized ZnDTP, but if results are expressed in terms of weld load, better performances are obtained with ZnDTP synthetized from secondary alcohols. AW results show that the effectiveness of ZnDTP from secondary alcohols is slightly higher when the alcohols used contain less than six carbon atoms. Beyond six carbon atoms in primary or secondary alcohol molecules, performances decrease. (b On the FZG gear rig, EP-AW results show that performances do not depend on the primary or secondary nature of the alcohols used, and that the smaller the hydrocarbon chain of these alcohols, the better the performances. The results of this work indicate that ZnDTP is the most effective of the MDTP we have studied. For ZnDTP prepared from different alcohols and alkylphenols the performances depend not only on the chemical structure of the additive, but also on contact conditions (kinematic, material types, etc. , and on the criteria considered (seizure load, weld load, wear, etc. Cet article apporte une contribution aux connaissances sur les performances antiusure et extrême-pression des dialkyldithiophosphates métalliques en général, et des dialkyldithiophosphates de zinc en particulier. Elle montre les différences de comportement antiusure et extrême-pression de ces composés dans des contacts métalliques lubrifiés caractéristiques tels que la classique machine 4 Billes et, ce qui constitue en soit une originalité, la machine à engrenages FZG. Elle souligne aussi que les performances enregistrées, sur une machine d'essais donnée, dépendent des critères d'appréciation choisis.

  4. Intelligent networks: evolution or revolution? Source of energy efficiency or economical optimisation? For who's benefit?; Reseaux intelligents: evolution ou revolution? Source d'efficacite energetique et/ou d'optimisation economique? Au benefice de qui?

    Energy Technology Data Exchange (ETDEWEB)

    Fontaine, Christian

    2010-09-15

    The electricity sector has experienced a slow evolution. Renewable production developments and telecommunications and computers usage will bring major changes with hard to predict effects. Computerized management of production and local storage combined to a certain mastering of the allowed consumption by home automation could improve reliability and the final price for consumers. This change offers great opportunities but also risks of failures, both financial and technical. The regulators have a major role to play in order to understand the concrete gains of the technological propositions and to regulate the investment costs involved. [French] Le secteur de l'electricite a connu une evolution lente. Le developpements des productions renouvelables, l'utilisation des telecommunications et de l'informatique provoquera un bouleversement majeur dont il est difficile de prevoir l'ampleur. La gestion automatisee des productions et stockages locaux combinee a une certaine maitrise de la consommation permise par la domotique pourrait ameliorer la fiabilite et le prix final pour les consommateurs. Ce changement presente de grandes opportunites mais aussi des risques d'echecs, tant financiers que techniques. Les regulateurs ont un role majeur a jouer pour comprendre les gains concrets des propositions technologiques et reguler les couts d'investissement qu'elles impliquent.

  5. Délivrance orale d'insuline par double encapsulation : développement et évaluation de l'efficacité et de la sécurité des systèmes entériques et nanoparticulaires

    OpenAIRE

    Guhmann, Pauline

    2013-01-01

    Up to date, the subcutaneous injection of insulin is the sole way available on market for blood glucose control in type 1 diabetic patients. This doctoral thesis is part of in ORAIL project, which aim is to develop a system for oral insulin delivery using double encapsulation, and validate its efficiency and safety in vitro, using an intestinal epithelium model, and in vivo in rats. The pharmaceutical carrier developed here in, comprises a capsule containing nanoparticles (NPs) of insulin for...

  6. Prognosis value of the COX-2 expression on radiotherapy efficiency and on survival without progression of patients reached by an unoperative glioblastoma; Valeur pronostique de l'expression de COX-2 sur l'efficacite de la radiotherapie et sur la survie sans progression des patients atteints d'un glioblastome inoperable

    Energy Technology Data Exchange (ETDEWEB)

    Simon, J.M.; Mazeron, J.J. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Service de Radiotherapie Oncologique, 75 - Paris (France); Mokhtari, K. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Lab. de Neuropathologie, 75 - Paris (France); Genestie, C. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Lab. d' Anatomie Pathologique, 75 - Paris (France); Bissery, A. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Dept. de biostatistiques et d' Anformation Medicale, 75 - Paris (France); Jaillon, P. [Hopital Saint-Antoine, Service de Pharmacologie, 75 - Paris (France)

    2006-11-15

    The expression of COX-2 is a prediction factor of the lack of response to the radiotherapy of glioblastomas and a less good survival rate without tumor progression, aside other known prognosis factors. These results suggest a selective treatment by an anti-COX-2 could have a radiosensitizer contribution during the radiotherapy of glioblastomas. (N.C.)

  7. Energie-Cites opinion on the directive project of CHP. To meet urban energy requirements with optimal energy efficiency and production closer to residents; Avis d'Energie-Cites sur le project de directive cogeneration. Satisfaire les besoins energetiques urbains avec la meilleure efficacite energetique et une production plus proche des habitants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-01-01

    The Directive on ''the promotion of cogeneration based on a useful heat demand in the internal energy market'' should be adopted very soon. The initial aim of the Directive is to strengthen existing measures to promote CHP in line with the Community target of doubling the share of CHP in EU electricity generation from 9% in 1994 to 18% by 2010. But no target has been mentioned. Energie-Cites states, in this document, its opinion of this draft proposal. Cogeneration is a well-tried and proven technology which has achieved tangible results and is one of the more efficient ways for the EU to fulfill the commitments it made under the Kyoto Protocol. (A.L.B.)

  8. Opinion of Energie-Cites on: Proposals for a directive of the European Parliament and of the Council; Avis d'Energie-Cites sur la: proposition de directive du parlement europeen et du conseil relative a l'efficacite energetique dans les utilisations finales et aux services energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-01

    The Proposal for a Directive on energy end-use efficiency and energy services, published in December 2003, is intended to develop and encourage energy efficiency on the demand side, in particular that provided by utilities and related services companies in the form of energy services, since promoting energy services is an important element for reducing greenhouse gas emissions. This proposal, focusing on the promotion of end-use efficiency, should be regarded as a necessary instrument to complement the recently adopted legislation on the opening of the internal energy market, which mainly leads to efficiency improvements on the supply side. (A.L.B.)

  9. Opinion of Energie-Cites on: proposal for a directive of the European parliament and of the council; Avis d'Energie-Cites sur la: proposition de directive du parlement Europeen et du conseil relative a l'efficacite energetique dans les utilisations finales et aux services energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-01

    This proposal, focusing on the promotion of end-use efficiency, should be regarded as a necessary instrument to complement the recently adopted legislation on the opening of the internal energy market, which mainly leads to efficiency improvements on the supply side. Memorandum Considering that the functioning of the energy market does not allow ''market forces to allocate economic and natural resources effectively'' and that measures should be taken to improve this, the Commission draws up a list of the main obstacles and presents objectives. The technical potential for savings is at about 40%. The economic cost-effective savings potential is at about 20%, 22% in the buildings sector. The general target is 1 % savings per year. The 1,5 % target in the public sector is therefore more ambitious that the general target. According to the Commission, energy efficiency is a strategy to deal with scarce public funds while at the same time addressing serious energy and climate challenges, using the concept of leadership by example. It presents also the economic impact of energy savings targets and explains the reasons why the local authorities are affected by the proposed directive (Municipalities are energy consumers, the municipalities are energy distributors and/or retailers, the municipalities are planners/investors, the municipalities are motivators and local growth and employment are of concern to local authorities). (A.L.B.)

  10. Meels: municipalities and energy efficiency in a liberalized system. Guidelines for municipalities: adapting to new roles in a liberalized market; Meels: les municipalites et l'efficacite energetique dans un systeme liberalise. Recommandations detinees aux municipalites: comment peuvent-elles s'adapter a leurs nouveaux roles dans un marche liberalise?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Even if the liberalization of energy markets seems to make it more difficult, it also creates opportunities for the committed local authority. Local authorities fulfill their functions in the energy sphere via a number of roles: as a consumer of energy, as a producer of energy, as a distributor of energy, as a trader of energy, as a regulator, planner and policy maker regarding energy using activities, as an awareness tool of the issues relating to energy use and as a provider of incentives to improve energy performance. There are impacts of liberalization on each of these roles. In most, liberalization has not actually changed what they do, only the degree of attention that should be given to it. Only in those areas where trading is involved are new skills necessary, for instance in purchasing energy, in transporting one own energy and in trading energy. In this framework, the following topics are successively analyzed: Improving performance as an energy consumer, improving performance as an energy producer, improving performance as an energy trader, improving performance as an energy distributor, improving performance in delivering sustainable, energy policies at local level and improving performance as a facilitator and awareness programs. (A.L.B.)

  11. Etude de l'efficacité de la fonctionnalisation des acides aminés au MTBSTFA après hydrolyse acide et dans différentes matrices minérales analogues martiennes : application aux expériences Sample Analysis at Mars (SAM) et Mars Organic Molecule Analyzer (MOMA)

    OpenAIRE

    Brault, Amaury

    2015-01-01

    Three main ways of study allow us to search for traces of life in the Universe: remote analysis, laboratory analysis of extraterrestrial material fallen or brought back to Earth, and in situ analysis. In association with chemical derivatization, Gas Chromatography coupled to Mass Spectrometry (GC-MS) is the method of predilection used for the separation and identification of organic compounds of astrobiological interest, whether on Earth or beyond. This work firstly deals with the impact of s...

  12. L'impact d'un Système Public d'Information sur l'intégration et l'efficacité des marchés : une application du modèle "Parity Bounds" au cas du maïs au Bénin

    Directory of Open Access Journals (Sweden)

    Kpenavoun Chogou, S.

    2013-01-01

    Full Text Available Measuring the impact of Public Market Information Systems on market integration and efficiency: an application of the Parity Bounds Model in maize markets in Benin. During the 1990s, agricultural market reforms prevailed within the economic liberalization undertaken in many sub-Saharan countries. In these countries, government intervention in the commodity markets through marketing boards or parastatal organizations was abandoned in favor of new market reforms. Public Market Information Systems (PMIS thus emerged as part of these reforms. Even though great positive impacts were expected from these reforms, little empirical work has been carried out to evaluate their effects. This article investigates how PMIS has affected the market performance of maize, a major staple food crop in Benin. We use a modified version of the Parity Bounds Model (PBM. This method allows the estimation of the rates of spatial market efficiency or integration, but also the estimation of the rates of market arbitrage, autarky, profitable opportunities and the violation of market arbitrage conditions. Results showed that Benin's agricultural sector suffered from a lack of quality training in how to follow the government-supported market information system implemented in the early 1990s. Subsequently, PMIS did not significantly improve the degree of market integration, although the reforms did induce new marketing opportunities. Results also showed that the impact of PMIS is limited by other market imperfections, such as entry barriers for non-residents or for persons not in local informal trade organizations, and the non-transparent enforcement of formal regulations. This study therefore recommends the implementation of more efficiency-raising policies in order to encourage competition and to allow PMIS to fulfill the expectations of farmers and consumers. Improving food producers and traders' access to reliable information will allow them to better exploit the market opportunities induced by the reforms.

  13. Efficacité comparée de divers procédés physiques de séparation des argiles d'un sable de gisement A Comparison of Different Physical Processes for the Recovery of Clays from an Unconsolidated Sandstone

    Directory of Open Access Journals (Sweden)

    Yvon J.

    2006-11-01

    Full Text Available Divers procédés physiques (mixage, attrition, vibration ultra-sonique ont été utilisés pour désagréger et disperser les argiles d'un sable de gisement. Le traitement aux ultra-sons s'est avéré le plus efficace : après 10 min de vibration on récupère environ 1,5 fois plus de particules fines ( The characterizing of clays is an essential operation for understanding many problems encountered in production. It goes via a preliminary phase in which species are separated quickly and effectively without altering their nature. Chemical processes disperse clays by solubilizing their cements, amorphous compounds and poorly crystallized oxyhydroxides. But they attack fragile species and lead to mistaken results. Therefore, we have chosen various physical processes (mixing, attrition, ultrasonic vibration and compared their efficacy with a reservoir sand. This sand was a quartzose arenite in which 96. 6 % of the grains were between 63 µm and 2 mm. The < 40 µm fine fraction, obtained by wet sieving, represented 2. 44 % of the unprocessed sand, and the clayey fraction (kaolinite, illite, montmorillonite, interstratified illite-montmorillonite was 1. 20%. Mixing was done with a bladed stirer. 40 g of sand and 100 cm³ of demineralized water were stirred for 3 min at a speed of 3000 rpm. Attrition was done by two devices :(1 For attrition by rotation, 400 g of sand and 0. 5 liter of demineralized water were placed in a porcelain jar rotating at a speed of 37 rpm. Tests were performed with water alone and with the adding of a dispersant (0. 3 % sodium hexametaphosphate and a surfactant (0. 6 mole/liter of sodium sulfonate paraoctylphenyl. (2 Attrition by a Turbula TC2 mixer, which gave the jar a complex rotation movement including shaking and rhythmic rocking. 500 g of sand were thus processed in 1 literof 3 % sodium hexametaphosphate solution for varying times. Ultrasonic processing was done with a Sonifer 830 device. The probe was plunged into a suspension made up of 440 g of sand and 300 cm³ of demineralized water processed for times varying from 5 to 100 min. The efficacy of the processing was measured by the weight percent of the < 40 µm fraction. This percentage was 2. 08 % on the average for mixing, 2. 60 % for simple rotation and 2. 87% for rotation by the Turbula device. The adding of dispersant or surfactant had no significant effect. Increasing the rotation time had a minimal effect, in that the percentage of particles recovered went from 2. 21 to 2. 60 % when time increased from 6 to 24 h. Ultrasonic processing was by far the most efficacious and fastest. Indeed, after 5min, an average of 3. 60% of < 40 µm particles was recovered, 4. 10 % after 10 min and7. 18 % after 100 min. The SEM examination of the fractions processed showed that only ultrasonic processing was capable of recovering all of the free clays, either pellicular or trapped in the dissolution cavities or cracks of the quartz grains, i. e. the so-called activeclays. It was also found that this recovery is selective. Montmorillonite and illite are set free at the beginning, while kaolinite is released all during the tests. At the beginning, it was disordered kaolinite, but after 15-20 min of processing, it was ordered kaolinite coming from the microdivision of mica crystals with which it had been associated. This microdivision is clearly visible, moreover, on the cumulative grain-size curve of the < 40µm particles recovered after ultrasonic processing. This curve has two parts:(1 The first part has a steep positive slope linked to the recovery of activeclays. (2 The second part has a much gentler slope linked to the recovery of clayey aggregates and mica and quartz grains microdivided by ultrasounds. The tests performed and a bibliographic study of various processes and operating conditions led us to choose ultrasounds as the process for separating clays from a reservoir sand. The best results were obtained with the following experimental conditions : instrument frequence = 200 kHz, instrument power = 210 W, suspension = 40 g of sand in 300 ml of demineralized water, processing time = 10 min. This quick and efficacious processing preserves the mineral species.

  14. In vivo preclinical low field MRI monitoring of tumor growth following a suicide gene therapy in an ortho-topic mice model of human glioblastoma;Controle par IRM bas champ in vivo de l'efficacite d'une therapie genique par gene suicide dans un modele murin de glioblastome orthotopique

    Energy Technology Data Exchange (ETDEWEB)

    Breton, E.; Goetz, Ch.; Aubertin, G.; Constantinesco, A.; Choquet, Ph. [Service de biophysique et medecine nucleaire, hopital de Hautepierre, CHRU de Strasbourg, 67 - Strasbourg (France); Institut de mecanique des fluides et des solides, CNRS, universite de Strasbourg, 67 - Strasbourg (France); Kintz, J.; Accart, N.; Grellier, B.; Erbs, Ph.; Rooke, R. [Transgene SA, parc d' innovation, 67 - Illkirch Graffenstaden (France)

    2010-03-15

    Purpose The aim of this study was to monitor in vivo with low field MRI growth of a murine ortho-topic glioma model following a suicide gene therapy. Methods The gene therapy consisted in the stereotactic injection in the mice brain of a modified vaccinia virus Ankara (M.V.A.) vector encoding for a suicide gene (FCU1) that transforms a non toxic pro-drug 5-fluoro-cytosine (5-F.C.) to its highly cytotoxic derivatives 5-fluorouracil (5-F.U.) and 5-fluoro-uridine-5 monophosphate (5-F.U.M.P.). Using a warmed-up imaging cell, sequential 3D T1 and T2 0.1T MRI brain examinations were performed on 16 Swiss female nu/nu mice bearing ortho-topic human glioblastoma (U 87-MG cells). The 6-week in vivo MRI follow-up consisted in a weekly measurement of the intracerebral tumor volume leading to a total of 65 examinations. Mice were divided in four groups: sham group (n = 4), sham group treated with 5-F.C. only (n = 4), sham group with injection of M.V.A.-FCU1 vector only (n = 4), therapy group administered with M.V.A.-FCU1 vector and 5-F.C. (n = 4). Measurements of tumor volumes were obtained after manual segmentation of T1- and T2-weighted images. Results Intra-observer and inter-observer tumor volume measurements show no significant differences. No differences were found between T1 and T2 volume tumor doubling times between the three sham groups. A significant statistical difference (p < 0.05) in T1 and T2 volume tumor doubling times between the three sham groups and the animals treated with the intratumoral injection of M.V.A.-FCU1 vector in combination with 2 weeks per os 5-F.C. administration was demonstrated. Conclusion Preclinical low field MRI was able to monitor efficacy of suicide gene therapy in delaying the tumor growth in an in vivo mouse model of ortho-topic glioblastoma. (authors)

  15. Security of energy supplies: the arguments of Mrs Loyola de Palacio. Nuclear energy: exit or restart. The Europe of renewable energies and energy efficiency; Securite d'approvisionnement energetique: les arguments de Mme Loyola de Palacio. Energie nucleaire: sortie ou relance. L'Europe des energies renouvelables et de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Palacio, L. de [Commission Europeenne de l' Energie et des Transports, 75 - Paris (France); Pierret, C. [Ministere de l' economie, des finances et de l' industrie, 75 - Paris (France); Schwartzenberg, R.G. [Ministere de la recherche, 75 - Paris (France); Bataille, C. [Assemblee Nationale, 75 - Paris (France); Bisson, E. [Direction Generale de l' Energie et des Matieres Premieres, 75 - Paris (France)

    2002-07-01

    This issue of Energies et Matieres Premieres journal comprises 3 articles. The first article is a reprint of the talk given by Mrs Loyola de Palacio at the French Institute of International Relations (IFRI) on July 5, 2001 about a safe and durable European strategy of energy supplies based on energy saving, on the development of renewable energy sources and on the role of nuclear energy in the fight against climate changes. The second article is a reprint of the talks given by C. Pierret (French State Secretary of Industry), by R.G. Schwartzenberg (French Minister of Research), by C. Bataille (Depute of the Nord region) and by the different participants to the round table of the colloquium on nuclear energy organized on November 6, 2001. The aim of the colloquium was to debate of the role the nuclear energy will have in the future energy and environmental challenges considering the increasing world energy demand and the reduction of greenhouse gases emissions. The last article deals with the 5. and 6. European R and D programs for the sustain of renewable energies and energy mastery. (J.S.)

  16. Monte Carlo molecular simulations: improving the statistical efficiency of samples with the help of artificial evolution algorithms; Simulations moleculaires de Monte Carlo: amelioration de l'efficacite statistique de l'echantillonnage grace aux algorithmes d'evolution artificielle

    Energy Technology Data Exchange (ETDEWEB)

    Leblanc, B.

    2002-03-01

    Molecular simulation aims at simulating particles in interaction, describing a physico-chemical system. When considering Markov Chain Monte Carlo sampling in this context, we often meet the same problem of statistical efficiency as with Molecular Dynamics for the simulation of complex molecules (polymers for example). The search for a correct sampling of the space of possible configurations with respect to the Boltzmann-Gibbs distribution is directly related to the statistical efficiency of such algorithms (i.e. the ability of rapidly providing uncorrelated states covering all the configuration space). We investigated how to improve this efficiency with the help of Artificial Evolution (AE). AE algorithms form a class of stochastic optimization algorithms inspired by Darwinian evolution. Efficiency measures that can be turned into efficiency criteria have been first searched before identifying parameters that could be optimized. Relative frequencies for each type of Monte Carlo moves, usually empirically chosen in reasonable ranges, were first considered. We combined parallel simulations with a 'genetic server' in order to dynamically improve the quality of the sampling during the simulations progress. Our results shows that in comparison with some reference settings, it is possible to improve the quality of samples with respect to the chosen criterion. The same algorithm has been applied to improve the Parallel Tempering technique, in order to optimize in the same time the relative frequencies of Monte Carlo moves and the relative frequencies of swapping between sub-systems simulated at different temperatures. Finally, hints for further research in order to optimize the choice of additional temperatures are given. (author)

  17. The School of Veterinary Medicine in St-Hyacinthe : energy efficiency and air quality, an inherent part of the new facility; Le CHUV de St-Hyacinthe : l'efficacite energetique et qualite de l'air, partie inherente des nouvelles installations

    Energy Technology Data Exchange (ETDEWEB)

    Havard, R. [SNC Lavalin, Montreal, PQ (Canada)

    2010-09-15

    This article described the expansion and modernization of the Centre Hospitalier Universitaire Veterinaire (CHUV) at the University of Montreal. The $74 million retrofit project at the School of Veterinary Medicine began in 2001 and was completed in 2008. The facility is considered to be a forerunner in the agribusiness. The facility can accommodate over 400 students at 3 different types of hospitals for pets, birds of prey, exotic animals, farm animals and equidae. Many challenges were addressed, including indoor air quality which requires specialized control for air temperature, humidity, and rigorous control of the dispersion of contaminants to ensure safety in each space. In addition to reliability, the infrastructure plan had to ensure exemplary energy performance and a reduction in costs. The energy system relies on a combination of electricity, natural gas and heat pumps for heating and cooling the premises. A novel ventilation system was designed to keep the operating rooms free of contaminants and to block contaminants from adjoining rooms. Contagious rooms requiring isolation are kept in slightly negative pressure, and air from these rooms is vented to the outside. It was concluded that the newly modernized facility meets the stringent conditions for thermal comfort in an energy efficiency manner. 3 figs.

  18. Effectiveness diagnostic of prostate specific antigen (P.S.A.) radioimmunoassay and the P.S.A. density to assess prostatic state of Ivorian patients; Efficacite diagnostique du dosage radio-isotopique et de la densite de l'antigene specifique de la prostate (P.S.A.) dans le bilan prostatique des sujets ivoiriens

    Energy Technology Data Exchange (ETDEWEB)

    Aboukoua-Kouassi, N.; Kouame-Koutouan, A.; Zunon-Kipre, E.; Achy, O.B.; Ndrin, N.K. [Cocody Univ., UFR sciences Medicales (SMA), Service de Biophysique et Medecine Nucleaire, Abidjan (Cote d' Ivoire); Achy, O.B.; Gnagne, Y.M. [Cocody Univ., Service d' Urologie, UFR/SMA, Abidjan (Cote d' Ivoire)

    2009-10-15

    By this first assay realized during two years, the authors wanted to assess the diagnostic performances of radioimmunoassay P.S.A., still unknown by Ivorian prescribers. It was about 78 patients who presented prostatic affections confirmed by histology. The dosages showed that, in prostate adenoma, a P.S.A. level was 9.5 ng/ml with P.S.A. density (P.S.A.D.) at 0.3. In prostate cancer, a P.S.A. level at 64.9 ng/ml with P.S.A.D. at 1.68. P.S.A. sensibility was good (91%) in spite of the value used, its specificity was about 94% for a level of 20 ng/ml. The predictive positive value was excellent with 20 ng/ml (95%). The risk to have prostate cancer with P.S.A. level of 10 ng/ml was 73.8% when rectal route (R.R.) was abnormal. The risk was low to 14.28% when the R.R. was normal. The radioimmunoassay of P.S.A. and P.S.A.D. rate improved significantly diagnostic indications in prostatic affections. Consequently, it must form part of first-line examination to the health assessment of old patients for a better prostatic lesions management. (authors)

  19. High efficiency technical solutions for domestic tumble dryer design and modeling of a dryer - with mechanical very humic air compression; Evaluation des solutions techniques a haute efficacite energetique pour les seche-linges domestiques - conception et modelisation d'un seche-linge a re-compression mecanique d'air tres humide

    Energy Technology Data Exchange (ETDEWEB)

    Palandre, L.

    2005-12-15

    The aim of this work is to evaluate high efficiency solutions for domestic tumble dryers. A specific analysis focuses on the thermodynamic cycle with very humid air compression. The main components are designed. In a first time, two technologies of dryers are studied: evacuation dryer, and condensation dryer. Drying cycles are measured and analyzed. The energy consumption for the standard 5 kg cotton cycle is in the range of 3.3 kWh and 3.6 kWh. Two alternative solutions are proposed to reduce significantly the energy consumption: a heat pump dryer with R-134a, or an open cycle using steam or very humid air as refrigerant. In both cases, the energy consumption is cut by a factor 2. The measurement of convective heat transfer coefficients between linen and humid air has allowed to elaborate a correlation giving the Lewis function evolution with very high absolute humidity. Heat exchanges in the tumble have been characterized. A correlation giving the heat transfer coefficient in function of air mass flow rate, linen mass, and its relative humidity, is developed. An unsteady-state model is developed. It gives the drying cycle of the tumble dryer with mechanical very humid air compression. Simulations show that drying time could be reduced to 1 hour using this process compared to 2 hours with R-134a heat pump dryers. (author)

  20. Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients. Results of the French RTF1 phase 2 trial; Tolerance et efficacite de la radiotherapie de conformation en cas de carcinome hepatocellulaire chez le patient cirrhotique. Resultats de l'essai de phase II RTF1

    Energy Technology Data Exchange (ETDEWEB)

    Mornex, F.; Girard, N.; Wautot, V.; Khodri, M. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Merle, P.; Kubas, A.; Trepo, C. [Hopital de l' Hotel-Dieu, Service d' hepatogastroenterologie, 69 - Lyon (France); Beziat, C. [Hopital de l' Hotel-Dieu, Dept. de Radiologie, 69 - Lyon (France)

    2005-11-15

    Purpose. - While some patients presenting with hepatocellular carcinoma (HCC) benefit from curative therapies (transplantation, surgery, percutaneous ablation), others are only candidates for palliative options such as chemo-embolization or symptomatic care. Although conventional external-beam radiotherapy of the liver is regarded as little efficient and potentially toxic in cirrhotic patients, 3-dimensional conformal radiotherapy (CRT), by decreasing the amount of normal liver included in the radiation portal, allows dose escalation to occur without increasing the risk of radiation-induced hepatitis. This trial was designed to assess the efficacy and tolerance of CRT for small-size HCC in cirrhotic patients. Patients and methods. - Prospective phase II trial including stage A/B cirrhotic patients with small-size HCC not suitable for curative treatments; CRT consisted in a standard fractionation radiation, with a total dose of 66 Gy. Results. - Twenty-seven patients were included, 15 of whom had previously been treated for HCC; mean age was 68. Among the 23 assessable patients, 18 (78%) presented with complete response, 3 (13%) with partial response, and 2 with no response. Acute complications occurred in 24 patients, and were mainly acceptable (grade 1/2: 22 patients, grade 3/4: 11 patients, 4 (15%) of whom had clinical and/or hematological toxicities). Only 2 (9%) grade 3/4 clinical and/or hematological late toxicities are reported. Conclusion. - CRT is a non-invasive curative technique highly suitable for small-size HCC in cirrhotic patients; further investigations are needed to compare it to the other available treatments, and to integrate it into the curative therapeutic algorithm of HCC. (author)

  1. Analyse de l'efficacité des stratégies de travail d'étudiants Lansad à distance dans un dispositif hybride – Étape d'une recherche-action Action research to evaluate ESP students' off site working strategies in a blended learning environment – interim report

    Directory of Open Access Journals (Sweden)

    Cédric Brudermann

    2010-05-01

    Full Text Available Cet article se propose de revenir sur la conception et l'utilisation d'un centre de ressources en ligne visant à mettre en œuvre des expériences d'apprentissage (Bange, 1992 potentiellement favorables à l'acquisition de l'anglais langue étrangère, dans un dispositif hybride d'enseignement / apprentissage des langues pour spécialistes d'autres disciplines (désormais Lansad. Une recherche expérimentale menée à l'institut universitaire de formation des maîtres (désormais IUFM de Perpignan auprès d'un public de professeurs des écoles de niveau B1 / B2 au cours de l'année universitaire 2007-2008 a permis de recueillir des données plus précises quant aux besoins des apprenants au cours de la réalisation de tâches écrites et orales à distance. Leur traitement a montré que la plupart des obstacles provenaient d'aspects de la langue anglaise de niveau A2 / B1 qui avaient déjà été travaillés par les apprenants lors de leurs études dans le secondaire. Pour les aider, un "centre de ressources en ligne" fonctionnant d'après leurs besoins en L2 a été conçu (Brudermann, 2008, de façon à leur laisser toute latitude pour se prendre en charge dans un climat sécurisé lors de la réalisation de ces travaux et les conduire à réinvestir leurs acquis dans l'élaboration de tâches ultérieures (Van Harmelen, 2006.This article deals with the implementation of an online database of pedagogical resources in a blended learning device, in order to lead ESP students to a potential improvement of their English as a foreign language knowledge. Action research was carried out in 2007-2008 in a French University (Perpignan amongst B1/B2 teachers-to-be ESP students. The data collected showed that most linguistic obstacles derived from A2/B1 elements they had already been taught during their secondary education. A database of pedagogical resources was set up online to provide students with relevant items and links when needed, whilst doing tasks and help them reinvest and reflect upon their FL knowledge (Van Harmelen, 2006.

  2. AQME memorandum to better understand the complexity of energy efficiency and its contribution to Quebec's energy sector; AQME memoire pour mieux comprendre la complexite de l'efficacite energetique et sa contribution au secteur energetique du Quebec

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-12-23

    This memorandum is the result of consultations that were undertaken in Quebec with respect to the energy sector. The report discusses energy safety both from a local and international perspective. It also examines several issues related to energy efficiency including: energy prices; barriers to energy efficiency; energy efficiency in buildings; energy efficiency in the public, commercial, and the residential sectors; as well as energy building regulations both for existing and new buildings. Energy efficiency is also examined from the perspectives of the industrial sector and the transport sector and from a public sensitization perspective. Last the report presents a national energy efficiency plan including a potential evaluation and discusses recommendations for partnerships to improve energy effectiveness. 4 tabs., figs.

  3. Patients volontaires présentant un épisode de toux sèche et venant consulter en médecine générale. | EU Clinical Trials Register [EU Clinical Trials Register

    Lifescience Database Archive (English)

    Full Text Available e l’efficacité d’Helicidine® versus Sirop à base de dextromethorphane sur la toux sèche des patients pris en....1Main objective of the trial Evaluer la non-infériorité d’Helicidine® versus Sirop à base de dextromethor...phane sur une durée de 5 jours de l’efficacité sur la toux sèche évalué par le scor

  4. Bart syndrome

    Directory of Open Access Journals (Sweden)

    Gaikwad Anil

    1993-01-01

    Full Text Available An infant presenting with extensive aplasia cutis on lower extremities later developed blisters on skin and mucous membrane. Clinical features and histopathological examination of skin favoured the diagnosis of Bart syndrome.

  5. Disease: H00637 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available autosomal dominant disorder caused by haploinsufficiency of the TBX3 gene. It is characterized by bilateral hypoplasia... or aplasia of upper limbs on the ulnar side, mammary and apocrine gland hypoplasia, and genital

  6. 75 FR 26258 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-05-11

    ..., pure red cell aplasia in immunosuppressed patients, and hydrops fetalis during ] pregnancy. In children... have duel functions as an initiator of TH1-type (cellular immunity) immune responses and as...

  7. Syndrome de Smith-Lemli-Opitz

    DEFF Research Database (Denmark)

    Pelluard-Nehmé, Fanny; Carles, Dominique; Alberti, Eve Marie;

    2005-01-01

    toe, postaxial polydactyly and genital anomalies with sexual ambiguity. We report a fetal case with intrauterine growth retardation, genital anomalies, multiple malformations with cardiac anomalies, renal aplasia and facial anomalies detected by prenatal ultrasound. Medical abortion was induced at 24...

  8. Spiral CT in aplasia of the pre-renal inferior vena cava as a cause of phlebothrombosis from the femoral veins to the inferior vena cava; Spiral-CT einer Aplasie der praerenalen Vena cava inferior als Ursache einer Phlebothrombose von den Oberschenkelvenen bis in die Vena cava inferior

    Energy Technology Data Exchange (ETDEWEB)

    Schweiger, U. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Freie Univ. Berlin (Germany); Schedel, H. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Freie Univ. Berlin (Germany); Thiede, U. [Deutsches Herzzentrum Berlin (Germany). Arbeitsgruppe Digitale Bildbearbeitung; Felix, R. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Freie Univ. Berlin (Germany)

    1994-12-31

    The case report focuses on the computed tomography of the thrombotic okklusion of the inferior vena cava, venae iliacae and femorales communes due to congenital interruption of the prerenal inferior vena cava. The embryology of the abnormality was discussed. (orig.) [Deutsch] Anhand einer Fallstudie wurden die Moeglichkeiten der computertomographischen Diagnostik bei einer durch Teilplasie der `praerenalen` Vena cava inferior hervorgerufenen Thrombose der Vv. femorales superficiales et profundae, der grossen Beckenvenen und der Vena cava inferior erlaeutert. In der Diskussion wurde auf die Embryologie der Missbildung eingegangen. (orig.)

  9. Clinical Study on Men's Pure Red Cell Aplasia Treated with Congrong Yishen Granule and Ciclosporina A%苁蓉益肾颗粒联合环孢菌素A治疗男性纯红细胞再生障碍的临床研究

    Institute of Scientific and Technical Information of China (English)

    吴佳丽; 成志; 俞聘; 陈均法

    2009-01-01

    目的:探讨苁蓉益肾颗粒联合环孢菌素A治疗男性纯红细胞再生障碍的疗效和机制.方法:48例患者随机分为两组,治疗组(24例)用苁蓉益肾颗粒联合环孢菌素A治疗,对照组(24例)用安特尔联合环孢菌素A治疗,两组均治疗12周,观察治疗前后两组相关临床指标(包括血红蛋白、红细胞、红细胞压积、睾酮、雌二醇、泌乳素、淋巴细胞亚群)的变化.结果:治疗12周后两组贫血指标均比治疗前有明显改善,两组疗效无明显差异.治疗后两组雌二醇、泌乳素水平较治疗前下降,睾酮水平较治疗前明显上升,两组对比无明显差异.淋巴细胞亚群分析表明治疗后两组CD+3、CD+8T淋巴细胞较治疗前明显下降,CD+4T淋巴细胞、CD4/CD8比值较治疗前明显上升(P<0.01),治疗后两组对比有统计学差异.结论:苁蓉益肾颗粒联合环孢菌素A治疗男性纯红细胞再生障碍有良好疗效,苁蓉益肾颗粒可通过促进睾酮分泌,刺激红细胞生成,并具有免疫调节作用.

  10. NEOPLASMS

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920632 Phenotypic analysis of T lympho-cytes from the patient with thymoma com-plicated with pure red cell aplasia. LIUBai(刘白), et al. Beijing Med Univ. Chin J Hema-tol 1992; 13(5): 244-246. The thymocytes in thymoma tissue and mono-nuclear cells in peripheral blood and bone marrowwere obtained from a patient with thymomacomplicated with pure red cell aplasia. The

  11. Report made on behalf of the inquiry commission for the enforcement of the measures preconized for the safety of the maritime transport of hazardous or polluting products and for the evaluation of their efficiency; Rapport fait au nom de la commission d'enquete sur l'application des mesures preconisees en matiere de securite du transport maritime des produits dangereux ou polluants et l'evaluation de leur efficacite

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    On February 5, 2003, three years after the creation of an inquiry commission about the Erika tanker-ship wreck, the principle of a new inquiry commission about the safety of maritime transports was decided by the French house of commons. Its mission is: to evaluate the efficiency of the existing measures of prevention of marine pollution by hydrocarbons, to examine if the preconized safety measures for the transport of dangerous or polluting products are effectively enforced, and to evaluate the status of the transposition of the European directives relative to the control of hazardous ships. This document is the first tome of the report made on behalf of this inquiry commission. It comprises four parts dealing with: 1 - the Prestige tanker-ship wreck and the pollution of Spanish and French coasts: similarities with the Erika wreck but differences in the conditions of crisis management, diverging accident analyses, problems encountered in Spain, a significantly improved management of the crisis by the French administration, the public opinion and the local economy, the global increase of maritime transport and the reduction of accidents frequency; 2 - the real improvements after the Erika wreck: the significant advances but their partial implementation, the acceleration of actions following the Prestige wreck; 3 - the expected and realistic perspectives: the sustain of the political will at the national scale, the concretizing of the European decisions and the follow up of the retained trends, the need for more outstanding evolutions at the international scale; 4 - the international liability and compensation regime: its limitation to the hydrocarbons pollution, the lack of victims indemnification in the case of chemical pollution, the need for an increase of the liability of all actors of the maritime transport and the improvement of the compensation system, a community compensation fund to compensate the inefficiencies of the international compensation mechanisms. (J.S.)

  12. Intra-operative implantation of Gliadel (BCNU, carmustine) wafers in patients suffering from a multiform glioblastoma and which are to be submitted to a concomitant radiotherapy and chemotherapy by temozolomide according to the Stupp protocol: efficiency and toxicity; Implanation peroperatoire de pastilles de Gliadel (BCNU, carmustine) chez des patients atteints d'un glioblatome multiforme devant recevoir par la suite une radiotherapie et une chimiotherapie concomitante par temozolomide selon le protocole de Stupp: efficacite et toxicite

    Energy Technology Data Exchange (ETDEWEB)

    Miglierini, P.; Bouchekoua, M.; Rousseau, B.; Malhaire, J.P.; Pradier, O. [Service de radiotherapie, ICH, CHU Morvan, 29 - Brest (France)

    2010-10-15

    The author report a study aimed at assessing the tolerance and efficiency of a technique which has been used for some years and which comprises the implantation of Gliadel wafers in the operative bed before performing a concomitant radiotherapy and chemotherapy with temozolomide, followed by six adjuvant chemotherapy sessions with the Stupp protocol. Four women and seven men have been implanted with Gliadel wafers. Only one patient did not have the concomitant chemo-radiotherapy. The global survival and global survival without progression have been assessed. Even though the obtained results are encouraging, the concomitant chemo-radiotherapy had to be stopped for three patients due to haematological consequences. Short communication

  13. Energy management in the patrimonial buildings of European territorial organizations in the framework of markets liberalization. Economic study of financial incentive mechanisms in favor of energy efficiency investment; Gestion de l'energie au sein du patrimoine bati des collectivites territoriales europeennes dans le cadre de la liberalisation des marches. Etude economique des mecanismes financiers favorisant l'investissement dans l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Gayral, L

    2005-12-15

    The territorial and patrimonial components of energy savings are not well developed because many barriers - political, organisational and financial - prevent investments in energy efficiency. Although investing in the improvement of the energy efficiency of their public buildings is a rational process, the local authorities are far from systematically carrying out this type of investment. Their limited investment capacity, associated to the lack of spare capital to finance their projects leads them to a 'vicious circle of energy wasting'. Our thesis analyzes the economic and financial tools a local authority can use to invest and enter a 'virtuous circle of energy efficiency'. Our topic deals with the financing of energy efficiency investments at a local level. We describe with details the functioning of each financial mechanism indexed. We illustrate their implementation within European municipalities through many case studies. Finally, we suggest recommendations for their broad reproducibility within French local authorities. (author)

  14. New modalities (setting, fractionation) of radioimmunotherapy by {sup 90}Y-ibritumomab tiuxetan ({sup 90}Y zevalin) in first line treatment of follicular type non Hodgkin malignant lymphomas: efficiency, toxicity and personalized dosimetry approach; Nouvelles modalites (consolidation, fractionnement) de radioimmunotherapie par {sup 90}Y-ibritumomab tiuxetan (Zevalin) en traitement de premiere ligne des lymphomes malin non hodgkiniens de type folliculaire: efficacite, toxicite et approche dosimetrique personnalisee

    Energy Technology Data Exchange (ETDEWEB)

    Morschhauser, F

    2008-12-15

    Rationale: radioimmunotherapy (R.I.T.) with {sup 90}Y-ibritumomab tiuxetan ([{sup 90}Y] Zevalin ) is a new treatment option for patients with relapsed/refractory non Hodgkin follicular lymphoma (F.L.). Efficacy increases when Zevalin is used earlier in the disease course. Currently, Zevalin dosage is based on weight and not dosimetry. This most likely results in a wide range of absorbed dose to critical organs and tumor, which in turn translates in unpredictable efficacy and toxicity. Optimizing R.I.T. with [{sup 90}Y] Zevalin will require its use as part of first-line therapy and implementation of patient-specific dosimetry methods in clinical trials. Objectives and methods: we have consecutively studied 2 new modalities of using Zevalin in first line therapy of F.L.. First, we conducted an international, randomized, phase 3 trial to evaluate the efficacy and safety of consolidation with Zevalin(15 MBq/Kg) in patients with advanced-stage F.L. achieving at least a partial response after induction immuno chemotherapy. A second approach consisted of evaluating a fractionated schedule with 2 doses of Zevalin (11.1 MBq/kg each), 9 to 13 weeks apart, as front line therapy in F.L. patients with high tumor burden. As part of this second approach, we designed a refined imaging-based (planar and 3-dimensional) dosimetry protocol to improve prediction of dose efficacy and toxicity after each dose of zevalin. Data acquisition was performed in 3 centers (Lille, Nantes and Manchester) while data treatment and specific dose calculations for major organ, tumor masses and bone marrow were centralized. Conclusion: Consolidation of first remission with {sup 90}Y-ibritumomab tiuxetan in advanced-stage follicular lymphoma is highly effective with no unexpected toxicities, prolonging P.F.S. by 2 years and resulting in high P.R.-to-C.R. conversion rates regardless of type of first-line induction treatment. Preliminary data show the feasibility of front line fractionated R.I.T. with Zevalin in patient with high tumor burden and of implementing a standardized refined data acquisition/treatment protocol for imaging-based dosimetry in the multicenter setting. Dosimetry results obtained for 6 patients who underwent patient-specific quantitative planar imaging after both Zevalin fractions will be presented. (author)

  15. Quebec's energy sector : context, issues and questions for a Quebec energy policy based on sustainable development and energy efficiency : memoire submitted by Vivre en Ville to the Quebec Commission of Economy and Labour; Le secteur energetique au Quebec : contexte, enjeux et questionnements pour une politique energetique quebecoise basee sur le developpement durable et l'efficacite energetique : memoire depose par Vivre en Ville au Quebec Commission de l'economie et du travail

    Energy Technology Data Exchange (ETDEWEB)

    Jampierre, V.; Vaillancourt, J.; Wright-Larin, I. [Vivre en Ville, Montreal, PQ (Canada)

    2005-01-11

    Vivre en Ville is a group of 225 activists from Quebec's health, environment, transportation and education sectors that promote sustainable living in the urban areas of the province. Their recommendations to save energy are based on principles of energy efficiency and combining resources to promote the use of common transportation corridors, diversified urban living and the protection and renovation of heritage sites. In addition to promoting the creation of parks and green spaces in urban areas, the group encourages residents to engage in municipal affairs by demanding solutions to transportation problems. Among their recommendations are a moratorium on the construction of new highways; upgrade existing mass transit systems to minimize personal vehicle use; increase funding for public transport; promote light rail transit to suburban areas; and devote special road lanes to collective transport such as taxis, buses and car pools. Other recommendations include the creation of more bicycle paths and centres that offer bikers shower and locker facilities. The group also believes that companies with more than 30 employees should be required to have transportation policies for its employees, such as organized car pools. Vivre en Quebec claims that too much energy has already been wasted and more action should be taken to implement these recommendations. tabs.

  16. Agenesis of the lung--a rare congenital anomaly of the lung.

    Science.gov (United States)

    De, Arun

    2013-01-01

    Pulmonary agenesis is a very rare condition and many of them are associated with a variety of cardiac and non-cardiac malformations. We report an eight-month old girl with chronic lung infection due to right sided pulmonary agenesis without any associated major cardiac or non-cardiac abnormalities. The case brings in forth the importance of investigating any infant presenting with features of chronic lung infection for any congenital abnormality of the lung including aplasia of the lung. This case also emphasizes that mildness of the attack does not exclude right sided aplasia of the lung.

  17. Agenesis of the Lung: A Rare Congenital Anomaly of the Lung

    Directory of Open Access Journals (Sweden)

    Arun De

    2013-01-01

    Full Text Available Pulmonary agenesis is a very rare condition and many of them are associated with a variety of cardiac and non-cardiac malformations. We report an eight-month old girl with chronic lung infection due to right sided pulmonary agenesis without any associated major cardiac or non-cardiac abnormalities. The case brings in forth the importance of investigating any infant presenting with features of chronic lung infection for any congenital abnormality of the lung including aplasia of the lung. This case also emphasizes that mildness of the attack does not exclude right sided aplasia of the lung.

  18. Narrow, duplicated internal auditory canal

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, T. [Servico de Neurorradiologia, Hospital Garcia de Orta, Avenida Torrado da Silva, 2801-951, Almada (Portugal); Shayestehfar, B. [Department of Radiology, UCLA Oliveview School of Medicine, Los Angeles, California (United States); Lufkin, R. [Department of Radiology, UCLA School of Medicine, Los Angeles, California (United States)

    2003-05-01

    A narrow internal auditory canal (IAC) constitutes a relative contraindication to cochlear implantation because it is associated with aplasia or hypoplasia of the vestibulocochlear nerve or its cochlear branch. We report an unusual case of a narrow, duplicated IAC, divided by a bony septum into a superior relatively large portion and an inferior stenotic portion, in which we could identify only the facial nerve. This case adds support to the association between a narrow IAC and aplasia or hypoplasia of the vestibulocochlear nerve. The normal facial nerve argues against the hypothesis that the narrow IAC is the result of a primary bony defect which inhibits the growth of the vestibulocochlear nerve. (orig.)

  19. School Choice Options Limit Access to Higher Education for Various Groups of Students in Quebec

    Science.gov (United States)

    Labrosse, Julie; Gaudreault, Marco; Picard, France

    2017-01-01

    The choice of selected school options by pupils in secondary school, particularly mathematics and physical sciences, have implications for future educational pathways in higher education [Felouzis, G. (1997). "L'efficacité des enseignants, Sociologie de la relation pédagogique." Paris: Presses Universitaires de France; Moreau, G. (2005).…

  20. Informatique: tous pour un ... projet

    CERN Multimedia

    Delétraz, F; Requin, J-M

    2004-01-01

    "Pour des raisons de coût et d'efficacité, les chercheurs font de plus en plus travailler ensemble des ordinateurs éparpillés sur tous les continents. Pour faire avancer la science, tous les moyens et tous les réseaux sont bons" (1 page)

  1. [Malaria and the work of two writer-physicians: Louis Ferdinand Celine and Carlo Levi].

    Science.gov (United States)

    Theodorides, J

    1999-01-01

    Malaria rarely mentioned in literary works has been dealt with by the two writers, both physicians, studied here. Louis-Ferdinand Destouches (1894-1961) alias Celine, studied medicine in Rennes and Paris from 1921 to 1924. He had been previously engaged by the Rockefeller Foundation to lecture on tuberculosis in Brittany. He later worked for the Commission of Hygiene of the League of Nations in Geneva and took part in 1925 to a long voyage in America (Cuba, United States) and Italy where malaria was still occurring. In 1926 he published a book: La quinine en therapeutique and participated to another voyage in West Africa where he contracted malaria. Numerous hints to this disease inspired to Celine by his first trip to Africa (Cameroun) in 1916-17 are found in Voyage au bout de la nuit (1932). Carlo Levi (1902-1975) studied medicine in Torino from 1919 to 1924. Painter and writer he wrote there his masterpiece: Christ has stopped in Eboli (1945). Malaria which then decimated a very poor population of peasants abandoned to themselves represents the background of the book and it is as a competent and human physician that C. Levi gained the friendship of the inhabitants of this remote and inhospitable province.

  2. Macro economic model in agriculture domain for the analysis of the climatic change impact and policies effects in term of efficiency and equity. Short version of the final report at the GICC, february 2002; Modele macro-economique a dominante agricole pour l'analyse de l'impact du changement climatique et des effets des politiques en terme d'efficacite et d'equite. Version abregee du rapport de fin d'etude au GICC, fevrier 2002

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, F.; Piketty, M.G.; Boussard, J.M

    2002-02-15

    The aim of the study is the determination of a detailed model of the world economy, allowing the simulation of the effect of numerous economic policies, especially those which are involved at a world scale to avoid the greenhouse effect gases emissions. This model is based on the previous model, as the GTAP from which the data are used. (A.L.B.)

  3. Air quality. How to give it back its original purity? The proliferation of air cleansers. Filters must be changed regularly. Measurement of the filtering efficiency of air treatment systems. The air treatment plants on the way of certification. Essential oils in a high building; Qualite de l'air. Comment lui rendre sa purete originelle? La proliferation des purificateurs d'air. Il faut changer les filtres regulierement. Mesure de l'efficacite de filtration des systemes de traitement d'air. Les centrales de traitement d'air sur la voie de la certification. Des huiles essentielles dans un immeuble de grande hauteur

    Energy Technology Data Exchange (ETDEWEB)

    Grumel, N.

    2000-07-01

    Outside air is polluted while the ambient indoor air is saturated with microorganisms. Inside buildings, the aeraulic networks are the link between both environments and the privileged place to clean the air using filtering systems. However, the notion of air quality is still badly perceived by owners, in particular in tertiary buildings. In France, efforts have to be made on the maintenance of aeraulic networks by hygiene specialists. Air quality inside buildings must be taken into consideration using communication and regulations. This dossier takes stock of the problem of air quality and of the available means to ensure a good air quality inside residential and tertiary buildings. The maintenance of air filters in one of the key points. It should be integrated in the general maintenance concept of buildings. The dossier includes a study of the in-situ measurement of the filtering efficiency of air treatment systems. This method is described in the Eurovent recommendation 4/10 of 1996. It has been experimented by the French technical centre of aeraulic and thermal industries (Cetiat) and the results are reported in the study. The performances of air treatment plants are now certified by Eurovent. This European organization has defined a program of tests which is conformable with the European EN 1886 and EN 13053 European standards. Finally, a new protocol of air decontamination based on the micronizing of essential oils in the aeraulic network of a 29 floors building is presented. (J.S.)

  4. Maxillary sinus agenesis - report of two cases; Agenesia do seio maxilar - relato de dois casos

    Energy Technology Data Exchange (ETDEWEB)

    Pierre, Jorge Henrique Arraes de Alencar; Santana, Expedito Araujo

    2000-04-01

    Agenesis or aplasia of the maxillary sinuses is an extremely rare condition, and only eight cases have been reported in the world medical literature. These malformations may arise as a result of developmental defects. Two cases of unilateral agenesis of the maxillary sinus are presented and the radiological abnormalities and the embryology are discussed. The literature is also reviewed. (author)

  5. Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

    Science.gov (United States)

    2005-06-23

    Purpura, Schoenlein-Henoch; Graft Versus Host Disease; Anemia, Hemolytic, Autoimmune; Rheumatoid Arthritis; Churg-Strauss Syndrome; Hypersensitivity Vasculitis; Wegener's Granulomatosis; Systemic Lupus Erythematosus; Giant Cell Arteritis; Pure Red Cell Aplasia; Juvenile Rheumatoid Arthritis; Polyarteritis Nodosa; Autoimmune Thrombocytopenic Purpura; Takayasu Arteritis

  6. Thymoma associated with severe diarrhoea and anaemia

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ About 40% of patients with thymoma have one or more paraneoplastic syndromes, including myasthenia gravis, pure red cell aplasia (PRCA) or hypogammaglobulinaemia, but Good syndrome occurs in only 5% of these conditions. To our knowledge, only 11 patients (including our cases) of thymoma accompanied with PRCA and Good syndrome have been reported,1 however, no such case was reported in China before 2000.

  7. Disease: H00464 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ndrome; Ear-patella-short statute syndrome Patella dysplasias are a group of disorders that include aplasia/hypoplasia...oplasia: a rare constituent of congenital syndromes. Acta Orthop Belg 69:29-34 (200... the nail-patella syndrome. Pediatr Radiol. 27:432-5 (1997) PMID:12666288 (description) Sferopoulos NK, Tsitouridis I Ischiopubic hyp

  8. Mutations in different components of FGF signaling in LADD syndrome.

    NARCIS (Netherlands)

    Rohmann, E.; Brunner, H.G.; Kayserili, H.; Uyguner, O.; Nurnberg, G.; Lew, E.D.; Dobbie, A.; Eswarakumar, V.P.; Uzumcu, A.; Ulubil-Emeroglu, M.; Leroy, J.G.; Li, Y.; Becker, C.; Lehnerdt, K.; Cremers, C.W.R.J.; Yuksel-Apak, M.; Nurnberg, P.; Kubisch, C.; Schlessinger, J.; Bokhoven, J.H.L.M. van; Wollnik, B.

    2006-01-01

    Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3

  9. Laparoscopy in 100 consecutive patients with 128 impalpable testes

    DEFF Research Database (Denmark)

    Cortes, D; Thorup, J M; Lenz, K

    1995-01-01

    neoplasia (carcinoma in situ) was found. Germ cell hypoplasia or aplasia was demonstrated in 95% of patients with testicular parenchyma. Additional diagnoses were made in 49% of patients with bilaterally undescended testes (one or both of which were impalpable). CONCLUSION: We recommend laparoscopy...

  10. Laparoskopi af 100 konsekutive patienter med 128 ikkepalpable testes

    DEFF Research Database (Denmark)

    Cortes, D; Thorup, J M; Lenz, K

    1996-01-01

    . No intratubular germ cell neoplasia (carcinoma in situ) was proved. Germ cell hypoplasia or aplasia was demonstrated in 95% of cases with testicular parenchyma. We recommend laparoscopy as a safe procedure which leads to a diagnosis in patients with impalpable testes; the advent of laparoscopic procedure makes...

  11. The morphology of the sella turcica in velocardiofacial syndrome suggests involvement of a neural crest developmental field

    DEFF Research Database (Denmark)

    Mølsted, Kirsten; Boers, Maria; Kjaer, Inger

    2010-01-01

    . The deviations were mostly in the posterior part of the dorsum sellae. Individuals with VCFS had increased cranial base angles. The results of this study combined with the information in the literature on the main defects in VCFS (palatal abnormalities, cardiac anomalies, thymic hypoplasia or aplasia...

  12. Cleidocranial dysostosis: a report on two familial cases

    Directory of Open Access Journals (Sweden)

    Carlos Guilherme Gaelzer Porciuncula

    2013-12-01

    Full Text Available Cleidocranial dysostosis is a rare genetic syndrome with an autosomal dominant inheritance pattern. The most common manifestations include clavicular aplasia or hypoplasia, open fontanelles and abnormal dentition. The present report describes two familial cases whose late diagnosis was made by means of clinical and radiographic findings. The treatment was radical, with complete surgical teeth extraction and making of total dental prosthesis.

  13. Bilateral duplication of the internal auditory canal

    Energy Technology Data Exchange (ETDEWEB)

    Weon, Young Cheol; Kim, Jae Hyoung; Choi, Sung Kyu [Seoul National University College of Medicine, Department of Radiology, Seoul National University Bundang Hospital, Seongnam-si (Korea); Koo, Ja-Won [Seoul National University College of Medicine, Department of Otolaryngology, Seoul National University Bundang Hospital, Seongnam-si (Korea)

    2007-10-15

    Duplication of the internal auditory canal is an extremely rare temporal bone anomaly that is believed to result from aplasia or hypoplasia of the vestibulocochlear nerve. We report bilateral duplication of the internal auditory canal in a 28-month-old boy with developmental delay and sensorineural hearing loss. (orig.)

  14. Holt Oram syndrome: a registry-based study in Europe

    DEFF Research Database (Denmark)

    Barisic, Ingeborg; Boban, Ljubica; Greenlees, Ruth

    2014-01-01

    were reported in all cases. Agenesis/hypoplasia of radius was present in 49.2% (30/61), ulnar aplasia/hypoplasia in 24.6% (15/61) and humerus hypoplasia/phocomelia in 42.6% (26/61) of patients. Congenital heart defects (CHD) were recorded in 78.7% (48/61) of patients. Isolated septal defects were...

  15. Tracheobronchial Branching Anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Min Ji; Kim, Young Tong; Jou, Sung Shick [Soonchunhyang University, Cheonan Hospital, Cheonan (Korea, Republic of); Park, A Young [Soonchunhyang University College of Medicine, Asan (Korea, Republic of)

    2010-04-15

    There are various congenital anomalies with respect to the number, length, diameter, and location of tracheobronchial branching patterns. The tracheobronchial anomalies are classified into two groups. The first one, anomalies of division, includes tracheal bronchus, cardiac bronchus, tracheal diverticulum, pulmonary isomerism, and minor variations. The second one, dysmorphic lung, includes lung agenesis-hypoplasia complex and lobar agenesis-aplasia complex

  16. Bilateral dyb venos trombose og vena cava-aplasi behandlet med lokal trombolyse

    DEFF Research Database (Denmark)

    Pelta, A.M.; Jorgensen, M.; Jensen, L.P.;

    2008-01-01

    In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete...

  17. Increasing Access to Modern Multidisciplinary Breast Cancer Care

    Science.gov (United States)

    1999-08-01

    less common breast tumors (tubular, medullary , papillary, mucinous). The good news is that the less common tumors are easier to cure. Often women who...Ratio 95% Cl hematological toxicity reached WHO grade 3-4 in 69% of cycles for neutrope- I nia, with 5 febrile aplasia but without anemia and

  18. AFRRI Reports, Third Quarter 1994

    Science.gov (United States)

    1994-10-01

    provided indirect evidence that reconstitution of medullary and extramedullary hematopoiesis after sublethal irradia- tion is mediated by...hemopoietic aplasia . Exp. Hematol. 21:338. 10. Schuening. F. G., F. R. Appelbaum, H. J. Deeg, M. Sullivan-Pepe, T. C Graham, R. Hackman, K. M. Zsebo

  19. Gene Expression of Hematoregulatory Cytokines is Elevated Endogenously After Sublethal Gamma Irradiation and is Differentially Enhanced by Therapeutic Administration of Biologic Response Modifiers

    Science.gov (United States)

    1994-01-01

    reconstitution of medullary Days After Irradiation and extramedullary hematopoiesis after sublethal irradia- FIGURE 7. Comparative elects of BRMs on 30-day...stimulating factor on recovery from radiation-induced hcmopoi,:tic Other studies have documented the absence of myeloid aplasia . EAp. henatoL 21:33W

  20. Publications and Technical Reports of the United States Army Research Institute of Environmental Medicine, 1961-1992

    Science.gov (United States)

    1992-09-30

    1092-1095, 1975. 427. Steffin, M. An oxygen dependent current in aplasia neurons: An approach to the question of cellular hypoxic adaptation... medullary response patterns. Journal of Avplied Phvsiologv, 70:8-14, 1991. 1167. Kraemer, W.J., S.E. Gordon, S.J. Fleck, L.J. Marchitelli, R. Mello, J.E

  1. The Effect of Irradiation on Bone Remodelling and the Structural Integrity of the Vertebral Column

    Science.gov (United States)

    1990-01-01

    1965. Schantz, A, AL Schiller and SP Kadish. Localized aplasia in irradiated vertebral bone marrow: A frequently overlooked gross observation. Arch...undergo the bone remodelling sequence together bone marrow-the soft, fatty substance filling the medullary cavaties and spongy extremities of the long

  2. [Amyoplasia congenita: a serious congenital abnormality with a relatively favorable prognosis

    NARCIS (Netherlands)

    Petru, R.; Verrips, A.; Ravenswaaij-Arts, C.M.A. van

    2002-01-01

    After an uneventful pregnancy a girl was born with serious joint contractures and several fractures of the long bones. The family history was negative for congenital abnormalities. Based on the distinct clinical presentation the diagnosis was 'amyoplasia', which is a partial aplasia of skeletal musc

  3. How bio-questionable are the different recombinant human erythropoietin copy products in Thailand?

    NARCIS (Netherlands)

    Halim, Liem Andhyk; Brinks, Vera; Jiskoot, Wim; Romeijn, Stefan; Praditpornsilpa, Kearkiat; Assawamakin, Anunchai; Schellekens, Huub

    2014-01-01

    PURPOSE: The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market. This study aims to assess the quality of

  4. mRNA translation regulation in Diamond Blackfan Anaemia

    NARCIS (Netherlands)

    R. Horos (Rastislav)

    2013-01-01

    textabstractDiamond Blackfan Anemia is a bone marrow failure syndrome in which patients lack erythroid precursor cells in the bone marrow. Therefore, it is also designated as pure red cell aplasia, as other hematological indices are at normal levels. Around half of DBA patients bear an autosomal dom

  5. Mutations in the human TBX4 gene cause small patella syndrome.

    NARCIS (Netherlands)

    Bongers, M.H.F.; Duijf, P.H.; Beersum, S.E.C. van; Schoots, J.; Kampen, A. van; Burckhardt, A.; Hamel, B.C.J.; Losan, F.; Hoefsloot, L.H.; Yntema, H.G.; Knoers, N.V.A.M.; Bokhoven, J.H.L.M. van

    2004-01-01

    Small patella syndrome (SPS) is an autosomal-dominant skeletal dysplasia characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami. We identified an SPS critical region of 5.6 cM on chromosome 17q22

  6. Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.

    NARCIS (Netherlands)

    Munnik, S.A. de; Bicknell, L.S.; Aftimos, S.; Al-Aama, J.Y.; Bever, Y. Van; Bober, M.B.; Clayton-Smith, J.; Edrees, A.Y.; Feingold, M.; Fryer, A.; Hagen, J.M. van; Hennekam, R.C.M.; Jansweijer, M.C.E.; Johnson, D.; Kant, S.G.; Opitz, J.M.; Ramadevi, A.R.; Reardon, W.; Ross, A.; Sarda, P.; Schrander-Stumpel, C.T.R.M.; Schoots, J.; Temple, I.K.; Terhal, P.A.; Toutain, A.; Wise, C.A.; Wright, M.; Skidmore, D.L.; Samuels, M.E.; Hoefsloot, L.H.; Knoers, N.V.A.M.; Brunner, H.G.; Jackson, A.P.; Bongers, M.H.F.

    2012-01-01

    Meier-Gorlin syndrome (MGS) is an autosomal recessive disorder characterized by microtia, patellar aplasia/hypoplasia, and short stature. Recently, mutations in five genes from the pre-replication complex (ORC1, ORC4, ORC6, CDT1, and CDC6), crucial in cell-cycle progression and growth, were identifi

  7. Clinical and molecular characterisation of human syndromes with congenital patellar malformations

    NARCIS (Netherlands)

    Bongers, M.H.F.

    2006-01-01

    In this thesis the results are described of clinical and molecular investigation of human syndromes with congenital patellar malformations as a hallmark feature, with emphasis on nail patella syndrome, small patella syndrome, isolated patellar aplasia or hypoplasia, and Meier-Gorlin syndrome. The el

  8. Meier-Gorlin syndrome: report of eight additional cases and review.

    NARCIS (Netherlands)

    Bongers, M.H.F.; Opitz, J.M.; Fryer, A.; Sarda, P.; Hennekam, R.C.M.; Hall, B.D.; Superneau, D.W.; Harbison, M.; Poss, A.; Bokhoven, J.H.L.M. van; Hamel, B.C.J.; Knoers, N.V.A.M.

    2001-01-01

    The Meier-Gorlin syndrome or ear, patella, short stature syndrome (MIM 224690) is a rare autosomal recessive disorder, characterized by the association of bilateral microtia, aplasia/hypoplasia of the patellae, and severe pre- and postnatal growth retardation. Twenty-one cases have been reported in

  9. Microphthalmia with linear skin defects syndrome.

    Science.gov (United States)

    García-Rabasco, Ana; De-Unamuno, Blanca; Martínez, Francisco; Febrer-Bosch, Isabel; Alegre-de-Miquel, Víctor

    2013-01-01

    Microphthalmia with linear skin defects (MLS) or microcornea, dermal aplasia and sclerocornea (MIDAS) syndrome is a rare X-linked-dominant disorder. We present a patient with agenesis of corpus callosum, ocular abnormalities, and multiple skin defects. The cytogenetic studies of the MLS critical region (Xp22.2) were normal, but a skewed X-chromosome inactivation pattern (85:15) was observed.

  10. Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway

    NARCIS (Netherlands)

    Heijnen, Harry F; van Wijk, Richard; Pereboom, Tamara C; Goos, Yvonne J; Seinen, Cor W; van Oirschot, Brigitte A; van Dooren, Rowie; Gastou, Marc; Giles, Rachel H; van Solinge, Wouter; Kuijpers, Taco W; Gazda, Hanna T; Bierings, Marc B; Da Costa, Lydie; MacInnes, Alyson W

    2014-01-01

    Mutations affecting the ribosome lead to several diseases known as ribosomopathies, with phenotypes that include growth defects, cytopenia, and bone marrow failure. Diamond-Blackfan anemia (DBA), for example, is a pure red cell aplasia linked to the mutation of ribosomal protein (RP) genes. Here we

  11. Pulsatile enophthalmos, severe esotropia, kinked optic nerve and visual loss in neurofibromatosis type-1

    Directory of Open Access Journals (Sweden)

    Virender Sachdeva

    2015-01-01

    Full Text Available Neurofibromatosis Type I if associated with aplasia of greater wing of sphenoid may be associated with a pulsatile exophthalmos. However, very rarely it may be associated with a pulsatile enophthalmos. This clinical image describes a rare presentation with pulsatile enophthalmos, esotropia and kinking of the optic nerve due to neurofibomatosis type I.

  12. Congenital inner ear malformation: three dimensional volume rendering image using MR CISS sequence

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jong Woon; Lee, In Sook; Kim, Hak Jin; Goh, Eui Kyung; Kim, Lee Suk [College of Medicine, Pusan National Univ., Pusan (Korea, Republic of)

    2003-10-01

    To evaluate three-dimensional volume-rendering of congenital inner-ear malformations using the MR CISS(Constructive Interference in Steady State) sequence. MR CISS images of 30 inner ears of 15 patients (M:F=10.5; mean age, 6.5years) in whom inner-ear malformation was suspected were obtained using a superconducting Magnetom Vision System (Simens, Erlangen, Germany), with TR/TE/FA parameters of 12.25 ms/5.9 ms/70.deg.. The images obtained were processed by means of the volume rendering technique at an advanced workstation (Voxtol 3.0.0; GE Systems, advanced workstation, volume analysis). The cochlea and three semicircular canals were morphologically evaluated. Volume-rendered images of 25 inner ears of 13 patients demonstrated cochlear anomalies in the form of incomplete partition (n=18), hypoplasia (n=2), and severe hypoplasia (n=5). For the superior semicircular canal, findings were normal in 15 ears, though common crus aplasia (n=6), hypoplasia (n=4), aplasia (n=3), and a short and broad shape (n=2) were also observed. The posterior semicircular canal of 13 ears was normal, but common crus aplasia (n=6), a short and broad shape (n=5), aplasia (n=4), hypoplasia (n=3) were also identified. Twelve lateral semicircular canals, were normal, but other images depicted a short and broad shape (n=7), a dilated crus (n=5), a broad shape (n=4), and aplasia (n=2). In 14 patients the anomalies were bilateral, and in seven, the same anomalies affected both ears. Three-dimensional volume rendering images of the inner ear depicted various morphological abnormalities of the cochlea and semicircular canals. At that locations, anomalies were more complicated and varied than in the cochlea. Three-dimensional volume rendering imaging using the MR CISS technique provides anatomical information regarding the membranous labyrinth, and we consider this useful in the evaluation of congenital inner ear malformations.

  13. Cognitive Effectiveness of CF18 Instructor Pilots during Routine Training

    Science.gov (United States)

    2007-02-01

    FASTTM). Sur la foi des données de sommeil et de vigilance, le programme prédit l’efficacité cognitive. Résultats. L’analyse FASTTM a prédit une...cognitive les plus faibles prévus (pendant la période de service de ces pilotes) avaient été causée par un sommeil insuffisant la nuit précédant les...World Safari. L’efficacité cognitive est déterminée par l’entrée de données quotidiennes sur le sommeil dans un programme de modélisation récemment

  14. Test des photomultiplicateurs en silicium couplés à un scintillateur plastique pour la nouvelle Tape Station

    CERN Document Server

    sekal, Smain

    2014-01-01

    L’une des parties essentielles de la l’installation ISOLDE est la tape Station (contrôleur de bandes), qui permet la vérification de la qualité du faisceau délivré aux expériences. On prévoit à ISOLDE de remplacer l’ancienne Tape Station, par une nouvelle Tape station; et l’un des paramètres essentiels pour la performance de la tape Station est l’efficacité de détection. Le but de ce travail est de vérifier l’efficacité des détecteurs de particules bêta, composés par l’association des photomultiplicateurs en Silicium à un scintillateur plastique pour differentes distances.

  15. Pertinence d’une représentation 3D d’un projet de rénovation de bâtiment en réalité augmentée mobile

    OpenAIRE

    LANDRIEU, Jérémie; NUGRAHA BAHAR, Yudi; Père, Christian; Merienne, Frédéric; Nicolle, Christophe

    2012-01-01

    National audience; Cet article aborde la possibilité de disposer de la maquette numérique d’un projet de construction sur le lieu même du déroulement des opérations. Le cas d’étude considère des travaux de rénovation sur des fenêtres anciennes dont il convient d’améliorer l’efficacité énergétique.

  16. Propagation Influences on Digital Transmission Systems: Problems and Solutions Held at Athens, Greece on 4-8 June 1984.

    Science.gov (United States)

    1984-06-08

    positive. Cos remarquos sont importantes pour la conception des modulatours -demodulateurs 4uoaapais EVALUATION EMPIRIQUE DE LA BANDE DE COHERENCE La...example of this is shown itc I() Fi ,uru _10(a) shows the refractive inidex profiles measured by radiosonde at the term- ;11i " a tesi littk Ii southerni...conno que, In ban- de lde fri~qunllce ) utiliqer 6tant dbtermin ,e, l’efficacit6 spectrale (nombre de communications par hertz) ceri plus importante si

  17. Du ralentissement de la croissance de l'économie francaise%评法国经济增长趋缓的原因

    Institute of Scientific and Technical Information of China (English)

    闫沐新

    2002-01-01

    le ralentissement de la croissance economique francaise depuis ces trente demieres annees est dO a l'insuffisance de la demande, des investissements, des progres technologiques, ainsi qu'a la rigidite des interventions de l'Etat. La relance economique a long terme exige une reduction de l'interventionisme de l'Etat et une ame1ioration de l'efficacite du marche, un choix politique.

  18. Clinical and symptomatological study of pigs subjected to a lethal dose of integral gamma irradiation; Etude clinique et symptomatologique chez le porc soumis a une irradiation gamma totale a dose letale

    Energy Technology Data Exchange (ETDEWEB)

    Vaiman, M.; Guenet, J.-L.; Maas, J.; Nizza, P

    1966-05-01

    Results are reported from a clinical and haematological study on a Corsican species of pigs wholly exposed to an approximately lethal dose of {gamma} radiation. The aim of this work was to examine the changes in the irradiation syndrome of irradiation for pigs to make it thus possible to devise further experiments, in particular in the therapeutic field. The dose received was 285 rads (measured as the absorption in the vertical antero-posterior medial plane). Data are presented on cyto-haematological changes in the blood circulating immediately after irradiation, and followed up to death, and changes in the medullary cytology after irradiation. The clinical picture of lethal radiation injury in swine is described. (authors) [French] Les auteurs rapportent les resultats d'une etude clinique et hematologique chez des porcs de race corse irradies in toto a dose sensiblement letale. Le but de cette etude etait de connaitre l'evolution du syndrome aigu d'irradiation chez le porc et de permettre ainsi le developpement d'experimentations ulterieures, en particulier dans le domaine therapeutique. La dose delivree etait de 285 rad (en dose absorbee au niveau du plan median vertical anteroposterieur. L'etude a porte essentiellement: 1. Sur les modifications cyclo-hematologiques du sang circulant immediatement apres l'irradiation, pour les differentes lignees cellulaires; l'evolution de ces modifications a ete notee jusqu'a la mort; 2. Sur les modifications de la cytologie medullaire apres irradiation (evolution du myelogramme et essai d'evaluation de la cellularite de la moelle osseuse);: 3. Sur les signes cliniques, d'ailleurs tres discrets, observes chez les porcs apres irradiation. (auteurs)

  19. Prevalence and patient characteristics of Mayer-Rokitansky-Küster-Hauser syndrome

    DEFF Research Database (Denmark)

    Herlin, Morten; Bjørn, Anne-Mette Bay; Rasmussen, Maria;

    2016-01-01

    to be around 1 in 4000-5000 females. However, population-based prevalence studies of MRKH syndrome are sparse. Moreover, population-based data on patient characteristics are lacking. STUDY DESIGN, SIZE, DURATION: This retrospective cohort study used the Danish National Patient Registry (DNPR) to identify...... a nationwide population-based cohort of patients with MRKH syndrome. Subsequently, patients were linked to the Danish Cytogenetic Central Registry (DCCR) and patient medical records in order to validate the diagnoses. PARTICIPANTS/MATERIALS, SETTING, METHODS: Hospitalizations and outpatient visits from 1994...... MRKH syndrome/Müllerian duct aplasia, Renal aplasia, and Cervicothoracic Somite dysplasia association were present in 56.5% and 43.5% of the patients, respectively. Kidney malformations were the most prevalent extragenital malformations, described in 38 of 111 patients (34.2%). However, in 57 patients...

  20. Cochlear implant: what the radiologist should know; Implante coclear: o que o radiologista precisa saber

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Natalia Delage; Couto, Caroline Laurita Batista; Gaiotti, Juliana Oggioni; Costa, Ana Maria Doffemond; Ribeiro, Marcelo Almeida; Diniz, Renata Lopes Furletti Caldeira, E-mail: nataliadelagegomes@gmail.com [Hospital Mater Dei, Belo Horizonte, MG (Brazil). Unidade de Radiologia e Diagnostico por Imagem

    2013-05-15

    Cochlear implant is the method of choice in the treatment of deep sensorineural hypoacusis, particularly in patients where conventional amplification devices do not imply noticeable clinical improvement. Imaging findings are crucial in the indication or contraindication for such surgical procedure. In the assessment of the temporal bone, radiologists should be familiar with relative or absolute contraindication factors, as well as with factors that might significantly complicate the implantation. Some criteria such as cochlear nerve aplasia, labyrinthine and/or cochlear aplasia are still considered as absolute contraindications, in spite of studies bringing such criteria into question. Cochlear dysplasias constitute relative contraindications, among them labyrinthitis ossificans is highlighted. Other alterations may be mentioned as complicating agents in the temporal bone assessment, namely, hypoplasia of the mastoid process, aberrant facial nerve, otomastoiditis, otosclerosis, dehiscent jugular bulb, enlarged endolymphatic duct and sac. The experienced radiologist assumes an important role in the evaluation of this condition. (author)

  1. Cochlear implant: what the radiologist should know

    Directory of Open Access Journals (Sweden)

    Natalia Delage Gomes

    2013-06-01

    Full Text Available Cochlear implant is the method of choice in the treatment of deep sensorineural hypoacusis, particularly in patients where conventional amplification devices do not imply noticeable clinical improvement. Imaging findings are crucial in the indication or contraindication for such surgical procedure. In the assessment of the temporal bone, radiologists should be familiar with relative or absolute contraindication factors, as well as with factors that might significantly complicate the implantation. Some criteria such as cochlear nerve aplasia, labyrinthine and/or cochlear aplasia are still considered as absolute contraindications, in spite of studies bringing such criteria into question. Cochlear dysplasias constitute relative contraindications, among them labyrinthitis ossificans is highlighted. Other alterations may be mentioned as complicating agents in the temporal bone assessment, namely, hypoplasia of the mastoid process, aberrant facial nerve, otomastoiditis, otosclerosis, dehiscent jugular bulb, enlarged endolymphatic duct and sac. The experienced radiologist assumes an important role in the evaluation of this condition.

  2. Oculoectodermal syndrome: twentieth described case with new manifestations*

    Science.gov (United States)

    Figueiras, Daniela de Almeida; Leal, Deborah Maria de Castro Barbosa; Kozmhinsky, Valter; Querino, Marina Coutinho Domingues; Regueira, Marina Genesia da Silva; Studart, Maria Gabriela de Morais

    2016-01-01

    Oculoectodermal syndrome is a rare disease characterized by the association of aplasia cutis congenita, epibulbar dermoids, and other abnormalities. This report describes the twentieth case of the disease. We report a 4-year-old female child who presented with the classical features of the syndrome: aplasia cutis congenita and epibulbar dermoids. Our case expands the clinical spectrum of the disease to include: diffuse hyperpigmentation (some following the Blaschko´s lines); hypopigmented skin areas on the trunk; arachnoid cyst on the right fronto-parietal border; rounded left side of the hippocampus; and dermoid cyst underlying the bulb-medullary transition. Our patient also reported infantile hemangioma on the right wrist and verrucous hemangioma on the left leg, the latter not previously described in the literature.

  3. CAR T-cells merge into the fast lane of cancer care.

    Science.gov (United States)

    Frey, Noelle V; Porter, David L

    2016-01-01

    Chimeric antigen receptors (CARs) can be introduced into T-cells redirecting them to target specific tumor antigens. CAR-modified T cells targeting CD19 have shown remarkable activity against CD19+ malignancies including B cell acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphomas (NHL). Complete remission rates as high as 90% have been observed for patients with relapsed and refractory ALL and greater than 50% response rates have been seen in heavily pre-treated CLL and NHL. Excitingly, some remissions have been durable without any additional therapy, a finding which correlates with in-vivo T-cell persistence and B-cell aplasia. The major treatment related toxicities include B-cell aplasia, neurologic toxicities, and a potentially severe cytokine release syndrome. This review summarizes outcomes for patients treated with CD19-CAR T-cells while exploring the field's challenges and future directions.

  4. Evaluation d'une approche pedagogique respectant les facons d'apprendre des filles en sciences et en TIC en 9e annee au Nouveau-Brunswick

    Science.gov (United States)

    Lirette-Pitre, Nicole T.

    2009-07-01

    La reussite scolaire des filles les amene de plus en plus a poursuivre une formation postsecondaire et a exercer des professions qui demandent un haut niveau de connaissances et d'expertise scientifique. Toutefois, les filles demeurent toujours tres peu nombreuses a envisager une carriere en sciences (chimie et physique), en ingenierie ou en TIC (technologie d'information et de la communication), soit une carriere reliee a la nouvelle economie. Pour plusieurs filles, les sciences et les TIC ne sont pas des matieres scolaires qu'elles trouvent interessantes meme si elles y reussissent tres bien. Ces filles admettent que leurs experiences d'apprentissage en sciences et en TIC ne leur ont pas permis de developper un interet ni de se sentir confiante en leurs habiletes a reussir dans ces matieres. Par consequent, peu de filles choisissent de poursuivre leurs etudes postsecondaires dans ces disciplines. La theorie sociocognitive du choix carriere a ete choisie comme modele theorique pour mieux comprendre quelles variables entrent en jeu lorsque les filles choisissent leur carriere. Notre etude a pour objet la conception et l'evaluation de l'efficacite d'un materiel pedagogique concu specifiquement pour ameliorer les experiences d'apprentissage en sciences et en TIC des filles de 9e annee au Nouveau-Brunswick. L'approche pedagogique privilegiee dans notre materiel a mis en oeuvre des strategies pedagogiques issues des meilleures pratiques que nous avons identifiees et qui visaient particulierement l'augmentation du sentiment d'auto-efficacite et de l'interet des filles pour ces disciplines. Ce materiel disponible par Internet a l'adresse http://www.umoncton.ca/lirettn/scientic est directement en lien avec le programme d'etudes en sciences de la nature de 9e annee du Nouveau-Brunswick. L'evaluation de l'efficacite de notre materiel pedagogique a ete faite selon deux grandes etapes methodologiques: 1) l'evaluation de l'utilisabilite et de la convivialite du materiel et 2

  5. Prenatal diagnosis of a case with anencephaly-omphalocele-unilateral absent radial ray.

    Science.gov (United States)

    Ceylaner, S; Ceylaner, G; Altun, M; Coşkun, A; Danisman, N

    2009-01-01

    We report here a female fetus with anencephaly, omphalocele and unilateral radial aplasia. The combination of two of these three malformations were reported in a number of patients diagnosed as Gershoni-Barush syndrome, ORR phenotype, VATER association, Schisis association, OEIS complex, Schinzel phocomelia syndrome and Acalvaria but they have not been reported all together in the same patient up to date. We hypothesize that, some or all these syndromes given above may be related etiologically.

  6. Scientific works of research workers of the army health service; Travaux scientifiques des chercheurs du service de sante des armees

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Ten articles about the effects of gamma radiation on human or animal cells are studied here. Regulation of cytokines, effect of interleukin 6, expression of the C-fos protein, interest of the study of a biological check up after an accidental irradiation, interaction and transport of cysteamine( radioprotector), approach of a treatment of radioinduced medullary aplasia, expression of TNF alpha and gelatinase B, are the subjects related here. (N.C.).

  7. Parvovirus-induced dyserythropoeisis in a child

    Directory of Open Access Journals (Sweden)

    Jain Deepali

    2008-07-01

    Full Text Available Most persons with parvovirus B19 infection are asymptomatic or exhibit mild, nonspecific, cold-like symptoms. However, hematologic problems associated with the infection include transient aplastic crisis, chronic red cell aplasia, mild neutropenia and thrombocytopenia. A rare hematologic manifestation is in the form of dyserythropoeisis. Herein, we present the case of a 9-year-old female with severe dyserythropoeisis associated with parvovirus infection.

  8. Creation of a Neovagina by Laparoscopic Modified Vecchietti Technique: Anatomic and Functional Results.

    Science.gov (United States)

    Baptista, Eduardo; Carvalho, Giselda; Nobre, Carlos; Dias, Isabel; Torgal, Isabel

    2016-09-01

    Purpose To evaluate the anatomic and functional results of a laparoscopic modified Vecchietti technique for the creation of a neovagina in patients with congenital vaginal aplasia. Methods Retrospective study of nine patients with congenital vaginal aplasia submitted to the laparoscopic Vecchietti procedure, in our department, between 2006 and 2013. The anatomical results were evaluated by assessing the length, width and epithelialization of the neovagina at the postoperative visits. The functional outcome was evaluated using the Rosen Female Sexual Function Index (FSFI) questionnaire and comparing the patients' results to those of a control group of 20 healthy women. The statistical analysis was performed using SPSS Statistics version 19.0 (IBM, Armonk, NY, USA), Student t-test, Mann-Whitney U test and Fisher exact test. Results The condition underlying the vaginal aplasia was Mayer-Rokitansky-Küster-Hauser syndrome in eight cases, and androgen insensitivity syndrome in one case. The average preoperative vaginal length was 2.9 cm. At surgery, the mean age of the patients was 22.2 years. The surgery was performed successfully in all patients and no intra or postoperative complications were recorded. At the first postoperative visit (6 to 8 weeks after surgery), the mean vaginal length was 8.1 cm. In all cases, the neovagina was epithelialized and had an appropriate width. The mean FSFI total and single domain scores did not differ significantly from those of the control group: 27.5 vs. 30.6 (total); 4.0 vs. 4.2 (desire); 4.4 vs. 5.2 (arousal); 5.2 vs. 5.3 (lubrication); 4.2 vs. 5.0 (orgasm); 5.3 vs. 5.5 (satisfaction) and 4.4 vs. 5.4 (comfort). Conclusions This modified laparoscopic Vecchietti technique is a simple, safe and effective procedure, which allows patients with congenital vaginal aplasia to have a satisfactory sexual activity, comparable to that of normal controls.

  9. Medical imaging for congenital anomalies of the lung. Focused on tracheobronchial and parenchymal anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Kohda, Ehiichi; Shiraga, Nobuyuki; Higuchi, Mutsumi; Ishibashi, Ryouchi [Tachikawa Hospital, Tokyo (Japan)

    2003-02-01

    This is a review of medical imaging studies for congenital anomalies of the lung focused on tracheobronchial and parenchymal anomalies. It is important to know the findings of these developmental anomalies, because they are frequently manifested as infectious diseases or mass. Documented details are pulmonary agenesis, aplasia, pulmonary hypoplasia, tracheal agenesis, bridging bronchus, tracheal bronchus, congenital tracheal stenosis, bronchial atresia, bronchobiliary fistula, bronchogenic cyst, bronchopulmonary sequestration, congenital cystic adenomatoid malformation, and pulmonary lymphangiectasia. (author)

  10. Conservative Treatment of a Patient with Epidermolysis Bullosa Presenting as Bart Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Samet Vasfi Kuvat

    2010-01-01

    Full Text Available We presented a case of a newborn male with aplasia cutis congenita on the lower limb. The case was treated with conservative method. As for the conservative treatment, daily hydrodebridement with 1/200 diluted povidone-iodine and serum physiologic was performed, followed by closure of the wound with a dexpanthenol + chlorhexidine + fusidic acid-impregnated sterile gauze bandage. the followup that occured after three weeks, the wound was completely epithelialized, but a hypopigmented scar remained in the limb.

  11. [Computed tomography and magnetic resonance imaging of congenital abnormalities of the temporal bone].

    Science.gov (United States)

    Czerny, C; Gstöttner, W; Imhof, H

    2003-03-01

    Congenital abnormalities of the temporal bone are mostly accompanied by conductive or sensori-neural hearing loss. Before any therapeutic procedures are done high resolution CT (HRCT) and magnetic resonance imaging (MRI) should be performed to establish the correct diagnosis and to plan the potentially surgical intervention. HRCT best depicts osseous changes especially those of the external auditory canal and the middle ear containing the ossicles and the osseous structures of the temporal bone and the petrous bone containing the inner ear. MRI excellently shows soft tissue changes of the inner ear especially on the high resolution 3DT2-weighted sequences which give a superb contrast between the nerves and the cerebro-spinal fluid. Malformations of the external auditory canal consists of aplasia or hypoplasia and those of the middle ear range form extreme hypoplasia or aplasia to very mild deformations of the ossicles. Malformations of the inner ear also range form complete aplasia to very mild hypoplasia of the organs of the inner ear as well as malformations concerning the nerves in the internal auditory canal range from aplasia to hypoplasia. Malformations of the temporal bone can either occur isolated or in combination in which malformations of the external and middle ear may be accompanied by those of the inner ear. Furthermore, malformations of the temporal bone may also occur in otofacial, otocervical or otoskeletal syndromes. These syndromes may be accompanied by certain malformations of the temporal bone. HRCT and MRI are both excellent methods to depict congenital abnormalities of the temporal bone and of the inner ear and should be used as complementary methods because HRCT best depicts osseous changes and MRI superbly depicts soft tissue changes. Both methods are important to establish the correct diagnosis to plan the therapeutic procedures.

  12. Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia.

    Science.gov (United States)

    Tekin, M; Oztürkmen Akay, H; Fitoz, S; Birnbaum, S; Cengiz, F B; Sennaroğlu, L; Incesulu, A; Yüksel Konuk, E B; Hasanefendioğlu Bayrak, A; Sentürk, S; Cebeci, I; Utine, G E; Tunçbilek, E; Nance, W E; Duman, D

    2008-06-01

    Homozygous mutations in the fibroblast growth factor 3 (FGF3) gene have recently been discovered in an autosomal recessive form of syndromic deafness characterized by complete labyrinthine aplasia (Michel aplasia), microtia, and microdontia (OMIM 610706 - LAMM). In order to better characterize the phenotypic spectrum associated with FGF3 mutations, we sequenced the FGF3 gene in 10 unrelated families in which probands had congenital deafness associated with various inner ear anomalies, including Michel aplasia, with or without tooth or external ear anomalies. FGF3 sequence changes were not found in eight unrelated probands with isolated inner ear anomalies or with a cochlear malformation along with auricle and tooth anomalies. We identified two new homozygous FGF3 mutations, p.Leu6Pro (c.17T>C) and p. Ile85MetfsX15 (c.254delT), in four subjects from two unrelated families with LAMM. The p.Leu6Pro mutation occurred within the signal site of FGF3 and is predicted to impair its secretion. The c.254delT mutation results in truncation of FGF3. Both mutations completely co-segregated with the phenotype, and heterozygotes did not have any of the phenotypic findings of LAMM. Some affected children had large skin tags on the upper side of the auricles, which is a distinctive clinical component of the syndrome. Enlarged collateral emissary veins associated with stenosis of the jugular foramen were noted on computerized tomographies of most affected subjects with FGF3 mutations. However, similar venous anomalies were also detected in persons with non-syndromic Michel aplasia, suggesting that a direct causative role of impaired FGF3 signaling is unlikely.

  13. Experiences from Cochlear Implantation and Auditory Brainstem Implantation in Adults and Children : Electrophysiological Measurements, Hearing Outcomes and Patient Satisfaction

    OpenAIRE

    Lundin, Karin

    2016-01-01

    Cochlear implants (CIs) and auditory brainstem implants (ABIs) are prostheses for hearing used in patients with profound hearing impairment. A CI requires an operational cochlear nerve to function in contrast to an ABI. ABIs were initially designed for adult patients with neurofibromatosis type 2 (NF2), suffering from bilateral vestibular schwannomas. Now ABIs are also used for patients, both adults and children, with congenital cochlear malformations, cochlear nerve hypoplasia/aplasia, and c...

  14. Chromosome and p63 Gene Analysis of an Infant with Ectrodactyly–Split Hand and Foot Malformation

    OpenAIRE

    DEMİRHAN, Osman

    2007-01-01

    Aim: Split hand-split foot malformation (SHFM) results from central ray reduction and presents as median clefts of the hands and feet, syndactyly, aplasia or hypoplasia of the phalanges, metacarpals and metatarsals, which are frequently associated with other phenotypic abnormalities. We aimed to investigate the genetic pathway of SHFM in a child. Materials and methods: Cytogenetic and molecular genetic analysis was performed in a 10-day-old boy with split-syndactyly hand and flat-syndactyly...

  15. 3D spheroid defects in NPHP knockdown cells are rescued by the somatostatin receptor agonist octreotide

    OpenAIRE

    Ghosh, Amiya K.; Hurd, Toby; Hildebrandt, Friedhelm

    2012-01-01

    Ciliopathies are a heterogeneous group of diseases that exhibit broad clinical phenotypes, including renal cysts, retinal degeneration, and cerebellar vermis aplasia. Nephronophthisis (NPHP) is a renal ciliopathy that causes chronic kidney disease and is characterized by kidney cysts at the cortico-medullary border. Among the 10 different disease-causing genes (NPHP1-NPHP10), mutations in NPHP3, NPHP6, or NPHP8 cause the most severe ciliopathy variants of NPHP, Joubert syndrome, and Meckel Sy...

  16. AFRRI (Armed Forces Radiobiology Research Institute) Annual Research Report 1 October 1981-30 September 1982.

    Science.gov (United States)

    1982-09-30

    activity were found in the kidney cortex after irradiation, but at 6 hours postirradiation, the values for the medullary Na-dependent, K-ATPase...induced lymphomyelopoietic aplasia and its attendant cellular and hunoral immune dysfunctions. Specific objec- tives include Novel applications of...The splenectomy emphasizes the medullary response to an intraperitoneal injection of 10 p’g Escherichia coli (LPS-W). Significant differences were

  17. Nuclear Weapon Effect Research at PSR (Pacific-Sierra Research Corporation) - 1983. Symptomatology of Acute Radiation Effects in Humans after Exposure to Doses of 75 to 4500 Rads (cGy) Free-in-Air

    Science.gov (United States)

    1984-08-31

    oblongata, the reflex is initiated by chemicals transported in the blood, impulses carried by autonomic fibers from abduminal organs to the medullary ...result not from direct radiation effects on the nervous system but from chemical compounds acting mainly on the medullary trigger zone.ý It is thought... aplasia and subsequent pancytopenia. References 14, 85. References 7, 65, 107. tReferences 13, 85. Reference 16. t t References 42, 50, 65, 81

  18. Annual Research Progress Report. Fiscal Year 1989. Volume 1

    Science.gov (United States)

    1989-10-01

    Patients Suspected of Having Pheochromocytoma, Paraganglioma or Medullary Hyperplasia. (0) C-58-89 Neuroimaging in Tourette Syndrome. (See C-57-89) (0...Assessment of Difluorodeoxycytidine (LY188011). Am. Soc. Clin. Onc., May 1989. (C) Vukelja, S.J., Kirshnan, J., et al. Resolution of Pure Red Cell Aplasia ...Evaluation of 13il-miBG ( Ji-meta-iodobenzylguanidine sulfate) in Patients Suspected of Having Pheochromocytoma, Paraganglioma or Medullary Hyperplasia

  19. AFRRI (Armed Forces Radiobiology Research Institute) Reports, January-March 1985

    Science.gov (United States)

    1985-01-01

    stains for cell sorting 56 genesis 213 Anticoagulants long-term hematopoiesis, role :472 granulocytic diffeentiation 56 medullary vs.extramedullary 215...functional ability of the mononuclear and macro- phage progeny of the M-CFC derived from the bone marrow and extra- medullary sources. The point to be...hemopoictic aplasia , the implications vival2’. The exact correlation between giucan’s hemo- and possible applications of glueall treatment are in- poietic

  20. USAFSAM Review and Analysis of Radiofrequency Radiation Bioeffects Literature. Fifth Report.

    Science.gov (United States)

    1985-03-01

    and the associated defects of protruding 0 tongue and aplasia of the upper cranial bones were evident in 17-22% of the fetuses; and other severe...focal vascular congestion. The cut surfaces of the kidneys showed congestion at the cortico- medullary junction and in the medulla. One tumor, a nodular...hypothalamic and medullary temperatures always above corresponding colonic temperatures. The plotted temperature data (brain vs colonic temperature) indicate a

  1. A Literature Review - Problem Definition Studies on Selected Toxic Chemicals. Volume 3. Occupational Health and Safety Aspects of 2,4,6-Trinitrotoluene (TNT)

    Science.gov (United States)

    1978-04-01

    observed (79). CLINICAL MANIFESTATIONS OF’TNT TOXICITY The main pathological manifestations of TNT toxicity are acute yellow atrophy of the liver, aplasia ...epithelium of the convuluted tubules. Straight tubules in the medullary zone contained brownish material. No fat globules were observed in the glomerult...heavily loaded with fat globules; the medullary portion, on the other hand, contained some brownish material which did not stain as hemosiderin. No

  2. BIZARRE CASE OF POLYDACTYLY WITH RIGHT MIRROR FOOT

    Directory of Open Access Journals (Sweden)

    Saif Omar

    2014-06-01

    Full Text Available Mirror foot, a form of polydactyly, is a rare congenital anomaly. In this form of congenital anomaly, there are several additional digits with accessory tarsal bones. It may be associated with fibular dimelia, tibial aplasia and tibial dysplasia. Cause of such anomaly is not known. On experimental basis it appears to involve ectopic SHH (Sonic hedgehog signaling in the limb bud mesenchyme

  3. Bone Marrow Transplantation for Severe Aplastic Anemia Secondary to Temozolomide

    OpenAIRE

    Morris, E. Brannon; Kasow, Kimberly; Reiss, Ulrike; Ellison, David; Broniscer, Alberto

    2008-01-01

    Radiotherapy (RT) and concomitant/adjuvant therapy with temozolomide (Temodar) is a common treatment regimen for children and adults with glioma. Although temozolomide is generally well tolerated with temporary myelosuppression as the primary dose-limiting toxicity, irreversible bone-marrow aplasia after treatment with temozolomide has been reported. We report the case of an adolescent patient with a high-grade glioma who, after > 2 years of event-free survival, underwent successful bone marr...

  4. Bronchiolitis as a feature of kartagener syndrome: a case report.

    Science.gov (United States)

    Ozkaya, Sevket; Sahin, Unal; Gumus, Aziz; Taşç, Filiz; Cnarka, Halit; Yavuz, Asiye

    2011-01-01

    Kartagener syndrome (KS), also known as immotile cilia syndrome or as a primary ciliary dyskinesia, is characterized by the triad of situs inversus, bronchiectasis, and chronic pansinusitis. A few studies reported that diffuse bronchiolitis might be one of the characteristic features of the lung in KS. We aimed to present the radiologic characteristics of KS, including diffuse bronchiolitis, sinus aplasia, and situs inversus totalis in a single case.

  5. Bilateral Carotid and Vertebral Rete Mirabile Presenting with a Prominent Anterior Spinal Artery Mimicking a Spinal Dural AV Fistula at MRI

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Young; Cha, Sang Hoon [Chungbuk National University College of Medicine, Iksan (Korea, Republic of)

    2011-11-15

    Bilateral carotid and vertebral rete mirabile (CVRM) is a very rare condition. We report a new case of CVRM initially detected by magnetic resonance imaging (MRI) of the cervical spine. MRI demonstrated tortuous vascular signal voids limited to the anterior cerebrospinal fluid space mimicking spinal dural arteriovenous fistula. A diagnosis of CVRM was confirmed on the basis of angiographic findings of rete formation associated with bilateral aplasia of the cavernous internal carotid and vertebral arteries without abnormal arteriovenous connection.

  6. 新生儿皮肤再生不良二例

    Institute of Scientific and Technical Information of China (English)

    王丹; 钱燕

    2009-01-01

    新生儿皮肤再生不良(aplasia cutis congential,ACC)是一种罕见的先天性皮肤局限或广泛缺损性疾病,以一定部位的皮肤缺损为特征,可伴有其他发育异常,现报道2例新生儿ACC。

  7. Quilopericárdio idiopático

    Directory of Open Access Journals (Sweden)

    Fernandes Fábio

    1998-01-01

    Full Text Available Descrevemos um caso de derrame pericárdico idiopático em que, durante investigação diagnóstica, foi constatado ser um quilopericárdio. A linfografia mostrou aplasia parcial do ducto torácico. Realizamos uma breve revisão da etiopatogenia, quadro clínico, métodos diagnósticos complementares e possibilidades terapêuticas do quilopericárdio.

  8. Chromosome 18q22.2-->qter deletion and a congenital anomaly syndrome with multiple vertebral segmentation defects.

    OpenAIRE

    Dowton, S B; Hing, A V; Sheen-Kaniecki, V; Watson, M. S.

    1997-01-01

    Multiple vertebral segmentation defects occur in a group of conditions variably associated with anomalies of other organ systems. This report describes a female child in whom a deletion of chromosome 18 (18q22.2-->qter) is associated with congenital anomalies including multiple vertebral segmentation defects resembling sporadic spondylocostal dysplasia. The child also has unilateral renal agenesis and unilateral fibular aplasia. The association of severe multiple vertebral segmentation defect...

  9. Poland syndrome with absent ribs

    OpenAIRE

    Rupam Kumar Ta; Kaushik Saha; Arnab Saha; Santanu Ghosh; Mrinmoy Mitra

    2014-01-01

    Poland syndrome is a rare congenital disorder characterized by ipsilateral absence of pectoralis major muscle. This syndrome is associated with various anomalies such as ipsilateral syndactyly, brachidactyly, dextrocardia, herniation of lung, underdevelopment of upper ribs, aplasia or hypoplasia of breast, etc. Only few cases had been reported with absent ribs in Poland syndrome. We report a rare case of Poland syndrome presented to us with mal-development of his right hemithorax and weakness...

  10. Poland syndrome with absent ribs

    Directory of Open Access Journals (Sweden)

    Rupam Kumar Ta

    2014-01-01

    Full Text Available Poland syndrome is a rare congenital disorder characterized by ipsilateral absence of pectoralis major muscle. This syndrome is associated with various anomalies such as ipsilateral syndactyly, brachidactyly, dextrocardia, herniation of lung, underdevelopment of upper ribs, aplasia or hypoplasia of breast, etc. Only few cases had been reported with absent ribs in Poland syndrome. We report a rare case of Poland syndrome presented to us with mal-development of his right hemithorax and weakness of right hand.

  11. Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária

    Directory of Open Access Journals (Sweden)

    R. C. N. Cubel

    1992-10-01

    Full Text Available Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia.

  12. Unilateral dysgenesis of the internal carotid artery: spectrum of imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    De Mendonca, J.L.F.; Viana, S.L.; Freitas, F.M.O.; Matos, V.L. [Magnetic Resonance Dept., Clinica Radiologica Vila Rica, Brasilia (Brazil)], E-mail: radiolog@uol.com.br; Viana, M.A.C.B. [Hospital de Base do Distrito Federal, Brasilia (Brazil); Silva, R.F. [Diagnostik, Hospital das Clinicas de Brasilia, Brasilia (Brazil); Quaglia, L.A.N. [Hospital Santa Lucia, Brasilia (Brazil); Guerra, J.G. [Hospital Regional de Taguatinga, Brasilia (Brazil)

    2008-04-15

    Dysgenesis of the internal carotid artery (ICA) is a broad term comprising hypoplasia, aplasia and agenesis of the vessel. It is a rare anomaly, often clinically silent, that can be confidently diagnosed by means of noninvasive imaging methods. After a review of teaching files, 7 patients with unilateral carotid dysgenesis were found, 2 with agenesis of the ICA, 3 with carotid aplasia, and 2 with hypoplasia of the vessel. Computed tomography (CT) and magnetic resonance angiography (MRA) of the brain were performed in all patients, with a complete magnetic resonance of the brain in 3 of them, a CT angiography of the brain in one, and MRA of the cervical arteries in 3. The fetal pattern of arterial circulation was found in 3 patients with agenesis/aplasia of the ICA and the adult pattern was found in 2 patients, being the brain circulation of normal pattern in the patients with hypoplasia of the ICA. Two patients presented signs of reduced flow to the brain hemisphere ipsilateral to the carotid dysgenesis; one of them with an old homolateral brain infarction. Far from being just an anatomic curiosity, the dysgenesis of the ICA may have serious consequences if not recognized prior to endarterectomies, carotid ligation or transsphenoidal surgery. As much as one-third of these patients will have intracranial aneurysms as well. The imaging methods, instead being mutually exclusive, are complementary in the evaluation of carotid dysgenesis. (author)

  13. Structures de données et méthodes formelles

    CERN Document Server

    Guyomard, Marc

    2011-01-01

    Ce livre porte sur l tude des structures de donn es, savoir des constituants logiciels dont la qualit conditionne le bon fonctionnement et l efficacit des applications informatiques. L originalit de cet ouvrage r side essentiellement dans le lien qu il tablit avec la discipline des m thodes formelles pour le g nie logiciel. Il montre comment il est possible de calculer les op rations qui accompagnent une structure de donn es partir d une sp cification rigoureuse. L auteur adopte la fois une perspective historique et une d marche fonctionnelle. La premi re partie de l ouvrage pr sente les bases

  14. Prise en compte de la performance des proof tests sur celle des systèmes instrumentés de sécurité

    OpenAIRE

    Mechri, Walid; Simon, Christophe; Bicking, Frédérique; Ben Othman, Kamel

    2015-01-01

    International audience; Cet article propose une approche pour analyser l'effet des proof tests dans l'évaluation de la performance des systèmes instrumentés de sécurité (SIS). L'analyse est basée sur les chaînes de Markov multiphases intégrant plusieurs paramètres tels que les défaillances de causes communes (DCC), le taux de couverture de diagnostic, les proofs tests, etc. Nous accordons une attention particulière à la performance et à l'efficacité des proof tests. Les concepts de base des c...

  15. Spot SAR ATR Using Wavelet Features and Neural Network Classifier

    Science.gov (United States)

    2005-10-01

    figur6s au moyen de courbes FER ( fonction d’efficacit6 du rdcepteur ) et de matrices de confusion. Les rdsultats analys6s montrent que les...feature variability for similar target types, and the highest variability for different target types. The ATR algorithm was implemented in Matlab using...neuronal MLP permet ensuite d’identifier les types d’une cible donn~e en fonction de ces signatures. On a d~termin6 I’ondelette optimale pour

  16. Les acteurs de l’aide au développement face à la montée de l’insécurité dans les pays du Sahel

    OpenAIRE

    Véron, Jean-Bernard

    2011-01-01

    « Terre d’humanitaire », le Sahel l’est aussi, et sans doute depuis plus longtemps encore, de « développement ». La montée de l’insécurité dans la région interroge autant l’efficacité des actions entreprises jusqu’à présent, que les modalités que peuvent mettre en œuvre les acteurs du développement pour contrarier cette spirale insécuritaire dont les premières victimes seraient les populations.

  17. Maniement des médicaments en néonatologie

    OpenAIRE

    Bouskhouri, Wissem; KHEDIM, Naziha

    2013-01-01

    Les essais cliniques permettent de tester l'efficacité et la toxicité des médicaments et de mettre ainsi au point des médicaments adaptés aux nouveau-nés en termes de posologie et de forme galénique. Mais pour cette population particulière, continuellement en maturation, leur réalisation est compliquée d'un point de vue éthique mais surtout peu rentable pour les firmes pharmaceutiques. Les soignants doivent ainsi utiliser les médicaments disponibles pour l'adulte, qui bien souv...

  18. The Relationship between Work-Life Conflict/Work-Life Balance and Operational Effectiveness in the Canadian Forces

    Science.gov (United States)

    2006-12-01

    fins de ce document, l’efficacité opérationnelle désigne les intentions de mouvement , le degré d’engagement envers le travail, la santé physique et...accroissement du rythme des affectations tient à une foule de facteurs, et notamment à la diminution de la taille des FC consécutive à la réduction par le...pendant l’instruction – désigne les intentions de mouvement , le degré d’engagement envers le travail, le rendement au travail, la santé physique et

  19. Etude simulée d'un système de dessalement d'eau de mer et de production de froid par thermofrigopompe couplée à des panneaux solaires

    OpenAIRE

    Byrne, Paul; Miriel, Jacques; Serres, Laurent; Ghoubali, Redouane

    2012-01-01

    International audience; L'accès à l'eau potable est un des enjeux majeurs des prochaines decennies. La recherche sur les technologies de dessalement à forte efficacité énergétique doit donc être particulièrement active. Cet article présente un système de thermofrigopompe produisant simultanément du froid pour une enceinte réfrigérée et de la chaleur utilisée par une unité de dessalement par distillation membranaire. L'énergie électrique est fournie par des panneaux photovoltaïques pour une po...

  20. Ruse, système et opportunité

    OpenAIRE

    2011-01-01

    Les musiciens professionnels de Roumanie portent un soin particulier à rendre leur jeu attachant, pénétrant et convaincant. Dans leurs commentaires, il est rare qu'ils attribuent cette efficacité à des règles, des systèmes ou des modèles mélodiques. D'après eux, les valeurs centrales pour la comprendre sont la ruse, la malice, l'adaptation et l'astuce. Liées à une conception interactionniste des performances musicales, ces notions invitent à reconsidérer le statut de la musique en général. Pl...

  1. Effects of Sea Motion on the Crew of the Petro Canada Terra Nova FPSO (Floating, Production, Storage and Offloading) Vessel

    Science.gov (United States)

    2004-10-01

    d’équipage souffrent de problèmes divers : troubles du sommeil , difficulté de terminer leurs tâches, perte d’efficacité, perte de concentration...performance dans ce type d’environnement. Un questionnaire sur les effets du mouvement – troubles du sommeil , symptômes et sévérité du mal de mer et...étaient peu nombreux, mais, comme prévu, les cas de troubles du sommeil , de la prise de décision et de la mémoire étaient beaucoup plus fréquents

  2. Alternative Submarine Watch Systems: Recommendation for a New CF Submarine Watch Schedule (Systemes Differents d’Horaire de Garde a Bord des Sous-Marins: Nouvel Horaire Recommande Pour les Sous-Marins des FC)

    Science.gov (United States)

    2010-01-01

    certains horaires peuvent nuire au sommeil et hypothéquer le rendement au travail. L’évaluation des horaires de garde à bord des sous-marins des FC...réalisée en 2007 a révélé des problèmes chroniques de sommeil et des niveaux dangereusement faibles d’efficacité cognitive chez les membres de l’équipage...du sommeil , le groupe de chercheurs a évalué trois horaires de garde différents, soit l’horaire à 1 tour sur trois de huit heures exigeant trois

  3. Free cash flow, gouvernance et politique financière des entreprises françaises

    OpenAIRE

    Mehdi Nekhili; Afifa Wali Siala; Dhikra Chebbi

    2009-01-01

    (VF)La limitation du problème du free cash flow dépend de l’efficacité des mécanismes de gouvernance. Dans notre étude, nous supposons que les mécanismes de gouvernance peuvent agir directement sur le niveau du free cash flow ou indirectement à travers les politiques d’endettement et de distribution de dividendes. Sur la base d’un échantillon de 123 entreprises françaises en 2004, les résultats montrent que c’est la distribution soutenue des dividendes, et non le niveau d’endettement, qui per...

  4. Cellules solaires photovoltaïques plastiques enjeux et perspectives

    Science.gov (United States)

    Sicot, L.; Dumarcher, V.; Raimond, P.; Rosilio, C.; Sentein, C.; Fiorini, C.

    2002-04-01

    Après avoir détaillé le fonctionnement d'une cellule photovoltaïque plastique et les paramètres photovoltaïques permettant de caractéiser son efficacité, un état de l'art des technologies de fabrication des cellules est présenté. Des moyens d'amélioration des performances des cellules photovoltaïques organiques sont ensuite illustrés par l'étude de dispositifs développés au Laboratoire Composants Organiques (LCO) du CEA Saclay.

  5. Le clonage somatique : un état des lieux chez les bovins et les petits ruminants

    OpenAIRE

    Heyman, Yvan; Chavatte-Palmer, Pascale; Vignon, Xavier; Richard, Christophe; Renard, Jean Paul

    2005-01-01

    Parmi les récentes biotechnologies de la reproduction chez les mammifères d’élevage, le clonage par transfert de noyaux somatiques constitue un pas en avant depuis la naissance de la brebis Dolly. Cet article fait le point sur les résultats actuels obtenus dans le monde chez les bovins et les petits ruminants, les limites de la technique et les applications potentielles. L’efficacité globale du clonage (nombre de jeunes nés /nombre d’embryons reconstitués) reste encore faible (≤ 7 %), mais el...

  6. Analysis of Governance and Management (GM) Approach Agility During the Vancouver 2010 Olympic Games

    Science.gov (United States)

    2011-10-01

    d’organisations doit être capable d’adopter une approche de gouvernance et de gestion (GG) adaptée à la complexité de la situation. Des changements...d’organisations doit être capable d’adopter une approche de gouvernance et de gestion (GG) adaptée à la complexité de la situation. Des changements, ou des...efficacité et efficience avec ces entreprises complexes, le groupe d’organisations doit être capable d’adopter une approche de gouvernance et de

  7. Assessing Vulnerability of Biometric Technologies for Identity Management Applications

    Science.gov (United States)

    2011-10-01

    télésurveillance et acquisition de données), et les services e- gouvernement , l’équipe d’étude pour PTSP-02-336BIOM a élaboré un cadre pour s’attaquer aux...cadre d’assurance de l’identité en ce qui concerne les systèmes informatiques, y compris les systèmes SCADA et des services e- gouvernement , et des...Les agences et ministères du gouvernement du Canada ont besoin d’information sur la performance, les vulnérabilités et l’efficacité des solutions

  8. Une nouvelle façon de gérer l'Etat et l'Administration : contrôle interne et audit publics

    OpenAIRE

    Cohen, Alain-Gérard

    2011-01-01

    Un nouveau modèle à vocation universelle Depuis une dizaine d'années se développe quasiment partout dans le monde, une réforme des Administrations publiques qui consiste à s'inspirer des méthodes de gestion du secteur privé : budget par objectifs, gestion axée sur les résultats, recherche de l'efficacité et de l'économie et non plus seulement respect de la régularité, évaluation des actions et des politiques publiques, volonté de transparence, responsabilisation des fonctionnaires, etc. Certe...

  9. Enterprise Risk Management: The Way Ahead for DRDC within the DND Enterprise

    Science.gov (United States)

    2010-03-01

    pas un nouveau domaine, mais plutôt une activité qui doit être intégrée à tous les niveaux et secteurs du Ministère pour en assurer l’efficacité...are some risk factors for which risk identification and assessment is a well developed art or science (e.g. financial) while there are other factors...will ensure that any proposals developed are benchmarked against Allied best practice and benefit from exposure to the state of the art thinking in

  10. Supply chain management et tableau de bord prospectif : à la recherche de synergies

    OpenAIRE

    MORANA, Joelle; Paché, Gilles

    2000-01-01

    National audience; Face à un environnement de plus en plus complexe et turbulent, des publications relativement onvergentes tendent à indiquer que l'efficacité d'une chaîne logistique globale se mesure à l'aune de son niveau de réactivité, de reconfiguration rapide des processus, d'élimination des gaspillages etd'intelligence. Si un relatif consensus se dégage ainsi sur les facteurs-clés de succès d'un supply chain management, force est de reconnaître que peu de hoses ont été dites et écrites...

  11. LE BALANCED SCORECARD REVISITE : DYNAMIQUE STRATEGIQUE ET PILOTAGE DE PERFORMANCE EXEMPLE D'UNE ENTREPRISE ENERGETIQUE

    OpenAIRE

    Lorino, Philippe

    2001-01-01

    International audience; Le tableau de bord (TdB) repose sur des jugements managériaux ayant trait à la pertinence stratégique des indicateurs (liaison cause-effet avec les objectifs stratégiques), leur pertinence opérationnelle (validité pour " mesurer " un type précis d'action) et leur efficacité cognitive (aptitude à " faire signe " pour les acteurs). Il semble donc plus pertinent de structurer le TdB sur la base des axes stratégiques, des processus d'action et de l'ergonomie cognitive, plu...

  12. Mise en place d'une veille mutualisée par le biais d'une plateforme de veille : conditions de mise en œuvre et impact sur la fonction documentaire. Le cas du Bureau de la documentation du Commissariat général au Développement durable

    OpenAIRE

    Castanet, Caroline

    2010-01-01

    Choisir d'utiliser une plateforme de veille pour mutualiser moyens humains et informationnels permet d'envisager des gains en efficacité et en qualité de service. C'est vers ce choix que s'est orienté le Bureau de la documentation du Commissariat général au Développement durable pour mieux répondre aux besoins de ses utilisateurs. Si les perspectives ouvertes par les fonctionnalités de ce type d'outil sont séduisantes, il faut néanmoins avoir conscience des enjeux humains et organisationnels ...

  13. Caroline Datchary, La Dispersion au travail

    Directory of Open Access Journals (Sweden)

    Guillaume Lecoeur

    2012-12-01

    Full Text Available Impression de ne pas pouvoir faire totalement son travail, insatisfaction, Trouble Musculo- Squelettique, mais aussi sentiment d’efficacité, d’excitation et parfois de plénitude. Ces sensations, bien qu’ambivalentes, ont néanmoins un point commun selon Caroline Datchary : elles sont engendrées par des situations de « dispersion au travail ». Mutation du travail oblige, les toujours Nouvelles Technologies de l’Information et de la Communication (NTIC ont fait leur apparition, la pression conc...

  14. Les représentations sociales de l'hypnose: une réflexion sur son acceptation dans les soins

    OpenAIRE

    Descloux, Fanny; Grosjean, Aïcha; Staffoni-Donadini, Liliana

    2013-01-01

    Introduction : De récentes études scientifiques ont prouvé l’efficacité de l’hypnose notamment pour la gestion des douleurs. Cependant elle est encore peu répandue dans les services hospitaliers en Suisse Romande. Les représentations sociales, façons personnelles de se représenter et d’interpréter le monde orientent le comportement humain. Concernant l’hypnose, elles jouent un rôle central dans les attitudes du patient et du thérapeute face à l’acceptation du phénomène. Objectif : Identifier ...

  15. Hypnose et douleurs chroniques: "est-ce que l'hypnose peut améliorer la qualité de vie des patients douloureux chroniques ?"

    OpenAIRE

    Granger, Julie; Duc, Céline; Hilfiker, Roger

    2012-01-01

    Au travers de cette revue systématique, nous souhaitons confirmer l’efficacité de l’hypnose dans le traitement de la douleur chronique. Nous avons recherché des études comparant deux groupes, l’un recevant uniquement des traitements physiothérapeutiques et l’autre de l’hypnose combinée à des traitements physiothérapeutiques. Mit dieser Systematischen Literaturübersicht möchten wir die Effizienz der Hypnose die Behandlung chronischer Schmerzen untersuchen. Wir haben Studien gesucht, die 2 G...

  16. Les tendinopathies et desmopathies des régions métacarpienne et –tarsienne: revue des thérapies actuelles. Seconde partie : les traitements

    OpenAIRE

    Verwilghen, Denis; Caudron, Isabelle; Van Galen, Gaby; Gabriel, Annick; Grulke, Sigrid; Serteyn, Didier

    2010-01-01

    Les lésions tendineuses sont fréquentes chez le cheval. Elles figurent en bonne place parmi les causes de mise à la retraite anticipée tant du cheval de sport que du cheval de loisir. Depuis des décennies l’homme est à la recherche de traitements « miracles » pour soigner les tendinites. La plupart des traitements utilisés jusqu’à présent étaient malheureusement empiriques et peu d’entre eux ont pu réellement prouver leur efficacité. Les techniques de diagnostic comme l’échographie permettent...

  17. L’application d’outils marketing au sein des associations touristiques

    OpenAIRE

    Pontier, Monique

    2011-01-01

    Au sein d’un contexte devenu concurrentiel, les associations touristiques se trouvent aujourd’hui face à des problématiques de recherche d’efficacité et de rentabilité nécessaires à leur survie, mais pouvant remettre en cause leur légitimité dans un secteur non lucratif. Des outils marketing sont ainsi mis en place afin de présenter aux publics une offre de qualité. Parmi ces méthodes, le marketing interne conduit les membres de l’association à devenir eux-mêmes acteurs de la commercialisatio...

  18. Exercices supervisés, à domicile ou manipulations (chiropraxie) pour les lombalgies chroniques

    OpenAIRE

    Duyver, Corentin

    2012-01-01

    Analyse de Bronfort G, Maiers MJ, Evans RL, et al. Supervised exercise, spinal manipulation, and home exercise for chronic low back pain: a randomized clinical trial. Spine 2011;11:585–98. Question clinique Quelle est l’efficacité à court et long terme d’un traitement basé sur des exercices supervisés versus des manipulations vertébrales (chiropraxie) et versus des exercices à domicile chez des patients présentant des lombalgies chroniques ? Conclusion Minerva Cette RCT ne montre pas de plus-...

  19. Coalition Battle Management Language (C-BML) (Language de gestion du champ de bataille (C-BML)

    Science.gov (United States)

    2012-02-01

    la plupart des nations participantes. Ils ont joué un rôle déterminant lors des exercices regroupés au sein de l’expérimentation finale. En accord...les systèmes C2 et les simulations afin d’améliorer l’efficacité et le bon déroulement des forces opérant en coalition lors des exercices ...robotic systems in the NATO context.” The primary objective of this TAP is stated as: “...to provide a NATO C-BML specification by analysing and

  20. Sleep and Modeled Performance of Arctic Patrollers during Operation Nunalivut 2010

    Science.gov (United States)

    2011-07-01

    l’efficacité cognitive pour chacun des 23 patrouilleurs de l’Arctique. Résultats et analyses : Les Rangers inuits ont dormi davantage dans leurs...pour les exercices dans l’Arctique doivent comprendre les répercussions du manque de sommeil sur l’état de préparation opérationnelle et planifier en...rythme opérationnel pour les exercices dans l’Arctique peut prévenir le manque de sommeil chez les patrouilleurs. Perspectives: Les planificateurs

  1. Protection biologique contre ravageurs aériens sur tomate sous abris : compte-rendu d'essai 2005

    OpenAIRE

    Mazollier, Catherine; Lambion, Jérôme; Ranc, Nicolas

    2006-01-01

    En agriculture biologique, les moyens de protection contre les ravageurs aériens sont coûteux et leur efficacité est parfois insuffisante. La pratique des brumisations sous abris réduit les températures et augmente l’hygrométrie, et peut améliorer la protection contre l’acarien Tetranychus urticae, comme l'ont montré les essais du GRAB conduits de 2002 à 2004 sur melon, aubergine et concombre. Cet essai a pour objectif d’étudier l’intérêt de la brumisation et de la lutte biologique contre l'e...

  2. Effet des Plastifiants sur la Temperature de Transition Vitreuse, Tg, du Butadiene a Terminaison Hydroxy et du Polyazoture de Glycidyle - Simulations et Experiences (Effect of the Plasticizers on the Vitreous Transition Temperature, Tg, of the Butadiene to Termination Hydroxy and the Polyazoture of Glycidyle - Simulations and Experiences)

    Science.gov (United States)

    2008-09-01

    se tourne vers les methodes mathematiques iteratives conduisant au minimum local. Afin de maximiser l’efficacite des calculs, on determine...coordonnees rt de l’atome. dV d2rt dr, ’ dt2 D’un point de vue mathematique , la principale difficulty de ces methodes est l’impossibilite...nombre d’atomes N, le volume Vet 1’energie E sont maintenus constants. C’est la methode la plus rapide mathematiquement , mais la moins utile pour la

  3. « Quantification des politiques versus Démocratisation de la mesure : la gestion publique par les indicateurs à l’épreuve de la participation. les indicateurs sont-ils solubles dans la participation ?

    OpenAIRE

    Fallon, Catherine

    2014-01-01

    L'évaluation des politiques publiques contribue à la fois à l’efficacité de l'action publique et à sa légitimation, en déployant une double logique pour renforcer l’intelligibilité et l’acceptabilité de la gestion publique. Cette démarche recourt de plus en plus souvent à des indicateurs de performances, sans questionner le caractère contingent et construit de leur émergence et le sacrifice de la complexité sociale qu'ils induisent. Une double dynamique est perceptible depuis quelques ann...

  4. Évaluation comparée de deux dispositifs scolaires destinés à des élèves ayant des troubles d’apprentissage

    OpenAIRE

    Tremblay, Philippe

    2013-01-01

    Cet article traite de la comparaison de l’efficacité de deux dispositifs scolaires (inclusion et enseignement spécialisé) destinés à des élèves ayant des difficultés ou des troubles d’apprentissage. Douze classes inclusives (groupe expérimental) et treize classes d’enseignement spécialisé (groupe contrôle) ont participé à la recherche. Les résultats montrent que les deux dispositifs se distinguent peu en ce qui concerne leur population et les ressources qui leur sont attribuées. Toutefois des...

  5. Modèles et mesures de l'influence de la communication : Nouvelles perspectives ouvertes par la psychologie sociale

    OpenAIRE

    Courbet, Didier; Fourquet-Courbet, Marie-Pierre

    2008-01-01

    International audience; La question de l'efficacité des actions de communication est au coeur des préoccupations des praticiens de la communication et du marketing. Pour concevoir des modèles d'aide à la décision, les chercheurs mobilisent souvent la psychologie sociale. L'objectif de l'article est de montrer comment de récentes recherches dans les domaines de la socio-cognition implicite et de la psychologie cognitive et linguistique ont été appliquées aux communications publicitaire et poli...

  6. La prise en charge de la douleur chronique chez les personnes âgées par les interventions infirmières de confort: massage, musicothérapie et imagerie guidée

    OpenAIRE

    Qaderdan, Wazhma; Torny, Cindy; Gueniat, Christophe

    2015-01-01

    Problématique : La douleur chronique est un problème bien réel chez les personnes âgées. Elle affecte les dimensions physiologique, psychique, sociale et spirituelle ainsi qu’engendre de nombreuses conséquences sur la qualité de vie. Les polypathologies affectant cette population, l’amène à la prise de nombreux médicaments, ce qui engendre entre autre, divers effets secondaires. But : L’objectif de ce travail est d’évaluer l’efficacité des interventions non-pharmacologiques que peuvent utilis...

  7. Application des techniques multiporteuses de type OFDM pour les futurs systèmes de télécommunications par satellite

    OpenAIRE

    Ho, Anh Tai

    2009-01-01

    Cette thèse étudie la possibilité d'appliquer les techniques de modulations multiporteuses de type OFDM dans les futurs systèmes de communications par satellite. Elle traite notamment du problème de synchronisation au niveau récepteur pour les systèmes de diffusion par satellite en bande Ka. L'objectif est de proposer une structure de réception ayant besoin du moins de ressources possibles pour synchroniser afin d'optimiser l'efficacité spectrale du système et obtenir un gain par rapport à un...

  8. Assessment of the impact of adherence and other predictors during HAART on various CD4 cell responses in resource-limited settings

    Directory of Open Access Journals (Sweden)

    Abrogoua DP

    2012-03-01

    Full Text Available Danho Pascal Abrogoua1,2, Brou Jerome Kablan1, Boua Alexis Thierry Kamenan1,3, Gilles Aulagner4, Konan N'Guessan1, Christian Zohoré11Laboratoire de Pharmacie Clinique, Pharmacologie et Therapeutique – UFR Sciences Pharmaceutiques et Biologiques, 2Laboratoire de Pharmacologie Clinique, CHU de Cocody, 3Service de Pharmacie, CHU de Cocody, Abidjan, Cote d'Ivoire, 4Service Pharmaceutique Hopital Louis Pradel, Lyon, FranceObjective: The aim of this study was to quantify, by modeling, the impact of significant predictors on CD4 cell response during antiretroviral therapy in a resource-limited setting.Methods: Modeling was used to determine which antiretroviral therapy response predictors (baseline CD4 cell count, clinical state, age, and adherence significantly influence immunological response in terms of CD4 cell gain compared to a reference value at different periods of monitoring.Results: At 6 months, CD4 cell response was significantly influenced by baseline CD4 count alone. The probability of no increase in CD4 cells was 2.6 higher in patients with a baseline CD4 cell count of ≥200/mm3. At 12 months, CD4 cell response was significantly influenced by both baseline CD4 cell count and adherence. The probability of no increase in CD4 cells was three times higher in patients with a baseline CD4 cell count of ≥200/mm3 and 0.15 times lower with adherent patients. At 18 months, CD4 cell response was also significantly influenced by both baseline CD4 cell count and adherence. The probability of no increase in CD4 cells was 5.1 times higher in patients with a baseline CD4 cell count of ≥200/mm3 and 0.28 times lower with adherent patients. At 24 months, optimal CD4 cell response was significantly influenced by adherence alone. Adherence increased the probability (by 5.8 of an optimal increase in CD4 cells. Age and baseline clinical state had no significant influence on immunological response.Conclusion: The relationship between adherence and CD4

  9. Ehrlichia canis infection in a dog with no history of travel outside the United Kingdom.

    Science.gov (United States)

    Wilson, H E; Mugford, A R; Humm, K R; Kellett-Gregory, L M

    2013-08-01

    A two-year-old female neutered Tibetan terrier was referred following a one-month history of lethargy, inappetence and pancytopenia, which had been poorly responsive to immunosuppressive and fluoroquinolone treatment. The dog was diagnosed with pure red cell aplasia and was found to be positive for Ehrlichia canis by both antibody titre measurement and polymerase chain reaction. The dog lived in London and had not travelled outside the UK. The dog was treated with doxycycline, prednisolone and ciclosporin, but died as a result of gastrointestinal tract haemorrhage. To the authors' knowledge, this represents the first reported case of Ehrlichia canis in a dog in the UK with no previous travel history.

  10. Ectodermal dysplasia - Maxillary and mandibular alveolar reconstruction with dental rehabilitation: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Deshpande Sanjeev

    2010-01-01

    Full Text Available Ectodermal dysplasia is a rare group of inherited disorders characterized by aplasia or dysplasia of tissues of ectodermal origin, such as hair, nails, teeth and skin. Dental manifestations include hypodontia, complete anodontia or malformed teeth. Oral rehabilitation is the major surgical challenge in such patients. It frequently requires alveolar reconstruction followed by dental implants. We report a case of hypohidrotic ectodermal dysplasia, which was managed with reconstruction of both the upper and the lower alveolus using free fibula flaps with dental rehabilitation using osseointegrated implants.

  11. [Management of pectus excavatum].

    Science.gov (United States)

    Gonzalez, Michel; Perentes, Jean Yannis; Abdelnour, Etienne; Wang, Yabo; Ris, Hans-Beat; Krueger, Thorsten

    2013-06-19

    Management of pectus excavatum Congenital chest wall deformities are considered to be anomalies in chest wall growth related to excessive or insufficient growth (aplasia or dysplasia) of the osseous or cartilaginous structures or the rib cage. These deformities are associated in 95% to overgrowth leading into depression (pectus excavatum) or protuberance of the sternum (pectus carinatum). Pectus excavatum may lead to cardiopulmonary disorder or impact on patient's self-esteem. The management of pectus excavatum has evolved this last decade with minimal invasive repair.

  12. Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma

    Institute of Scientific and Technical Information of China (English)

    Bernhard Glodny; Alexandar Tzankov; Germar-Michael Pinggera; Johannes Petersen; Ralf Herwig

    2006-01-01

    A 32-year-old man recovered completely from hypokalemic hypertension that had been caused by primary reninism after the ablation of an ectopic left testis, epididymis and ductus deferens. For several years, severe hypertension has been resistant to treatment, even the concurrent administration of up to seven antihypertensive agents. In this case,cryptorchidism was associated with an indirect inguinal hernia and an open peritoneo-vaginal process on both sides,aplasia of the posterior wall of the inguinal canal on the right side, an umbilical hernia, and a retroperitoneal tendrillar hemangioma.

  13. Carcinoma de células escamosas da hipofaringe em mulher jovem com anemia de Fanconi Squamous cell carcinoma of the hypopharynx in a young woman with Fanconi’s anemia

    OpenAIRE

    Henrique de Lins e Horta; Fernando Fernandes Guimarães; Luiz Otávio Savassi Rocha; Roberto Eustáquio Santos Guimarães; Eugênia Ribeiro Valadares

    2006-01-01

    A anemia de Fanconi é um raro distúrbio autossômico recessivo caracterizado por malformações congênitas, aplasia da medula óssea e instabilidade genômica, com predisposição ao desenvolvimento de neoplasias malignas, em especial as leucemias e os tumores do trato aerodigestivo alto. Em razão de características inerentes à síndrome em questão, o tratamento de tais neoplasias é particularmente difícil. Relata-se o caso de anemia de Fanconi uma jovem de 24 anos, que desenvolveu carcinoma de célul...

  14. Alteraciones cromosómicas estructurales inducidas por bioflavonoides de la dieta en linfocitos de anemia de Fanconi

    OpenAIRE

    Galeano, Liliana; Guevara, Gonzalo

    2010-01-01

    Introducción La anemia de Fanconi es una enfermedad genética con herencia autosómica recesiva caracterizada por aplasia medular, predisposición a leucemia mieloide aguda, tumores sólidos y aumento en la inestabilidad cromosómica. Este síndrome puede considerarse como modelo biológico para analizar sustancias naturales con posible efecto genotóxico, difíciles de evaluar en células normales. Los objetivos de este estudio son describir y cuantificar las alteraciones cromosómicas estructurales in...

  15. Right lung agenesis

    Directory of Open Access Journals (Sweden)

    Kumar B

    2008-01-01

    Full Text Available Congenital pulmonary agenesis or aplasia is extremely rare. Although more than fifty percent of patients die before first five years of age, some individuals may remain asymptomatic throughout their life. A three-month-old female child with right pulmonary agenesis presented to us with severe respiratory distress. She was misdiagnosed as a case of foreign body bronchus at the peripheral health centre. Bronchoscopy confirmed the diagnosis and relieved the symptoms. It is recommended that invasive diagnostic procedures and prophylactic surgery should not be done in asymptomatic cases.

  16. Prolonged gestation in two Holstein cows: transabdominal ultrasonographic findings in late pregnancy and pathologic findings in the fetuses.

    Science.gov (United States)

    Buczinski, S; Bélanger, A-M; Fecteau, G; Roy, J-P

    2007-12-01

    Prolonged pregnancy in cattle is a rare condition that is commonly accompanied with fetal adenohypophyseal hypoplasia. The final diagnosis is often challenging as breeding date error remains possible in virtually all situations. In this report, fetal wellbeing assessment is depicted in two Holstein cows suffered from prolonged pregnancy. Transabdominal ultrasonographic findings were compatible with healthy non-stressed fetuses. The clinical and pathologic findings encountered in both fetuses expelled after corticosteroid induction of parturition consisted of adenohypophyseal aplasia and hydronephrosis. Other nervous system anomalies (hydrocephaly or holocephaly) were observed. Tetralogy of Fallot was also found in one calf.

  17. Ultrasonography of various thyroid diseases in children and adolescents: A pictorial essay

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Sook; Lee, Eun Hye; Jeong, Sun Hye; Park, Ji Sang; Lee, Heon [Dept. of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon (Korea, Republic of)

    2015-04-15

    Thyroid imaging is indicated to evaluate congenital hypothyroidism during newborn screening or in cases of a palpable thyroid mass in children and adolescents. This pictorial essay reviews the ultrasonography (US) of thyroid diseases in children and adolescents, including normal thyroid gland development, imaging features of congenital thyroid disorders (dysgenesis, [aplasia, ectopy, hypoplasia], dyshormonogenesis, transient hypothyroidism, thyroglossal duct cyst), diffuse thyroid disease (Grave's disease, Hashimoto's thyroiditis, and suppurative thyroiditis), and thyroid nodules. The primary imaging modalities for evaluating thyroid diseases are US and radionuclide scintigraphy. Additionally, US can be used to guide aspiration of detected nodules.

  18. A Narrow Internal Auditory Canal with Duplication in a Patient with Congenital Sensorineural Hearing Loss

    Energy Technology Data Exchange (ETDEWEB)

    Baik, Hye Won; Yu, Hye On; Kim, Kyung Soo; Kim, Gi Hyeon [Chung-Ang University Hospital, College of Medicine, Seoul (Korea, Republic of)

    2008-07-15

    A narrow internal auditory canal (IAC) with duplication is a rare anomaly of the temporal bone. It is associated with congenital sensorineural hearing loss. Aplasia or hypoplasia of the vestibulocochlear nerve may cause the hearing loss. We present an unusual case of an isolated narrow IAC with duplication that was detected by a CT scan. In this case, the IAC was divided by a bony septum into an empty stenotic inferoposterior portion and a large anterosuperior portion containing the facial nerve that was clearly delineated on MRI.

  19. CT study of 17 cases of congenital cochlear abnormality. Embryologic and anatomo-functional relationship

    OpenAIRE

    Maurício, JC; Biscoito, L; Branco, G.

    1993-01-01

    In this review of cochlear malformations, 17 cases were studied by CT scan (high resolution-target program) including 10 males and 7 females. The anomaly was bilateral in 12 cases and unilateral in 7 (the latter included 2 Mondini type aplasias and one Michel). The cochlear malformation (whose most frequent expression was the cochlear hypoplasia with 1 or 1 1/2 spires-65% of the cases) was associated to semicircular canals and/or vestibular aqueduct anomaly in 82% of the patients; it was excl...

  20. Cochlear Implantation in Children with Cochlear Malformation.

    Science.gov (United States)

    Saikawa, Etsuko; Takano, Kenichi; Ogasawara, Noriko; Tsubomatsu, Chieko; Takahashi, Nozomi; Shirasaki, Hideaki; Himi, Tetsuo

    2016-01-01

    Cochlear implantation (CI) has proven to be an effective treatment for severe bilateral sensorineural hearing loss (SNHL). Inner ear malformation is a rare anomaly and occurs in approximately 20% of cases with congenital SNHL. In cases with cochlear malformation, CI can be successfully performed in nearly all patients, the exceptions being those with complete labyrinthine and cochlear aplasia. It is important to evaluate the severity of inner ear deformity and other associated anomalies during the preimplantation radiological assessment in order to identify any complication that may potentially occur during the surgery and subsequent patient management.

  1. Infecção por Chryseobacterium indologenes: relato de um caso Chryseobacterium indologenes infection: a case report

    OpenAIRE

    Renata de Souza Ferreira; Fabiana Ferreira Barbosa Brandão; Suzana Margareth Lobo

    2010-01-01

    Relatamos um caso de infecção por Chryseobacterium indologenes, presente na cultura de aspirado traqueal em paciente sob ventilação mecânica invasiva, revisando os aspectos epidemiológicos, microbiológicos e o tratamento na unidade de terapia intensiva. Paciente do sexo masculino, 30 anos, internado com quadro de aplasia de medula idiopática e neutropenia febril foi transferido para a unidade de terapia intensiva com quadro de broncopneumonia e sepse grave de origem pulmonar. A maioria dos ca...

  2. Reações adversas em pacientes com doença de Chagas tratados com benzonidazol, no Estado do Ceará Adverse reactions in Chagas disease patients treated with benznidazole, in the State of Ceará

    OpenAIRE

    Vânia Maria Oliveira de Pontes; Alcidésio Sales de Souza Júnior; Francisco Marcondes Tavares da Cruz; Helena Lutéscia Luna Coelho; Aparecida Tiemi Nagao Dias; Ivo Castelo Branco Coêlho; Maria de Fátima Oliveira

    2010-01-01

    INTRODUÇÃO: A doença de Chagas, causada pelo Trypanosoma cruzi, é tratada com benzonidazol, tendo o inconveniente de apresentar efetividade parcial e alta toxicidade, que varia desde reações de hipersensibilidade a aplasia medular. O objetivo foi descrever e avaliar a ocorrência de reações adversas em pacientes chagásicos em tratamento com benzonidazol em Fortaleza, Ceará. MÉTODOS: Estudo descritivo prospectivo envolvendo 32 pacientes chagásicos crônicos tratados com benzonidazol entre janeir...

  3. A rare case of Mayer-Rokitansky-Kuster-Hauser syndrome with multiple leiomyomas in hypoplastic uterus

    Directory of Open Access Journals (Sweden)

    Maithili Mandar Kulkarni

    2015-01-01

    Full Text Available Mayer-Rokitansky-Kuster-Hauser (MRKH syndrome is a rare disorder described as aplasia or hypoplasia of uterus and vagina due to an early arrest in development of mullerian ducts. Women with this syndrome are characterized by the presence of 46 XX karyotype, normal female secondary sex characters, normal ovarian functions, and underdeveloped vagina. The presence of leiomyoma in MRKH syndrome is very rare, and only few cases have been reported in the literature. Here, we report a case of MRKH syndrome with multiple leiomyomas originating from the rudimentary horn of uterus in 25 years married, phenotypically female patient.

  4. Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.

    LENUS (Irish Health Repository)

    Kelly, Kevin

    2008-12-01

    Aplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.

  5. The Effects of Nerve Growth Factor on Skin Healing and Blood Recovery in Irradiated Mice

    Institute of Scientific and Technical Information of China (English)

    史春梦; 程天民; 屈纪富

    2002-01-01

    @@ It is known that radiation could cause bone marrow aplasia and delay wound healing.To promote cellular proliferation and blood recovery are 2 major goals in the treatment of radiation injury.We have observed that the expression of nerve growth factor (NGF) gene decreased greatly in the wound tissue of irradiated animals by immunohistochemistry and in situ hybridization methods.This study was designed to elucidate the effects of NGF on the skin wound healing and blood recovery in mice after total body irradiation.

  6. Evaluation of cleft lip and palate by computed tomography with 2 mm thin slice scanning, 2

    Energy Technology Data Exchange (ETDEWEB)

    Uchiyama, Mayuki; Tanaka, Hiroshi; Harada, Junta (Jikei Univ., Tokyo (Japan). School of Medicine)

    1992-06-01

    Computed tomography was performed on 104 patients with cleft lip and palate by continuous 2 mm slice scanning. The type of hard palate was classified as normal, hypoplasia and aplasia, depending on its developmental degree. The shape of alveolus was also classified as circular, triangular and asymmetric forms for the evaluation of the maxillary development. The hard palate development correlated with the shape of the alveolus, the diameter of maxillary and mandibular bone, and frequency of sinusitis and otitis media. Evaluation of the hard palate by thin slice scanning is useful in presumption of future fecial development. (author).

  7. Terrorist threat, chemical, biological, radiological, nuclear medical approach; Menace terroriste, approche medicale nucleaire, radiologique, biologique, chimique

    Energy Technology Data Exchange (ETDEWEB)

    Revel, Th. de [Hopital d' Instruction des Armees Percy, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Clamart (France); Vidal, D. [Centre de Recherche du Service de Sante des Armees, 38 - La Tronche (France); Renaudeau, C. [Ecole du Val de Grace, 92 - Clamart (France)

    2005-07-01

    The different aspects linked to the use of nuclear, radiological, biological and or chemical weapons are gathered in this work. They concern history, fundamental aspect, diagnosis, therapy and prevention. The part devoted to the nuclear aspect concern the accidents in relation with ionizing radiations, the radiation syndrome, the contribution and limits of dosimetry, the treatment of medullary aplasia, the evaluation and treatment of an internal contamination, new perspectives on the use of cytokine for the treatment of accidental irradiated persons, alternative to the blood transfusion. (N.C.)

  8. Ankylosis of primary molar along with congenitally missing first permanent molar

    Directory of Open Access Journals (Sweden)

    Suprabha B

    2006-05-01

    Full Text Available Ankylosis of primary mandibular molars has been routinely found to be associated with various developmental disturbances in permanent dentition such as aplasia of the succedaneous tooth, ectopic eruption of the premolar, infraoclusion of the ankylosed tooth leading to tipping of the first permanent molar etc. This article describes a rare case where there was ankylosis of a mandibular second primary molar along with congenitally missing first permanent molar which resulted in the transposition of second premolar. Treatment options and prognosis of the case are discussed.

  9. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab.

    Science.gov (United States)

    Krishnan, Suresh K; Hill, Anita; Hillmen, Peter; Arnold, Louise M; Brooksbank, Gemma L; Wood, Alex; Scarsbrook, Andrew; Davies, Mervyn H; Kelly, Richard J

    2013-12-01

    Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which reduced the size of the spleen and improved his blood count to the point that blood transfusions were no longer necessary. Splenic embolization was chosen over splenectomy due to the potential postoperative complications of splenectomy, especially that of thrombosis.

  10. MURCS association--a review of 7 cases.

    Directory of Open Access Journals (Sweden)

    Mahajan P

    1992-07-01

    Full Text Available MURCS association (Mullerian hypoplasia/aplasia, renal agenesis and cervicothoracic somite dysplasia is emerging as the second most frequent cause of primary amenorrhoea after Turner syndrome. Seven cases have been described and analysed. All cases had absence of uterus and tubes 85% had cervical spine abnormalities such as vertebral fusion, hypoplasia of vertebrae or butterfly vertebrae and short stature and 28% had renal agenesis or ectopy. The latter finding is in contrast to the reports in world literature where the frequency of renal agenesis is higher. There was no familial incidence in these seven cases lending credence to the belief that the association is essentially sporadic.

  11. Developmental defects of the lungs

    Energy Technology Data Exchange (ETDEWEB)

    DaCosta, H.; Pathak, A.; Noronha, O.; Dalal, S.; Shah, K.; Merchant, S.

    1981-06-01

    Poor lung development was first noted on scintigraphy using sup(99m)Tc-phytate in 32 children. They had all been referred for a hepatosplenic scan but the initial circulatory phase of the radiopharmaceutical was also recorded as a routine procedure. In 3 patients it revealed aplasia of an entire lung; bilateral pulmonary hypolplasia was observed in 14 of 16 patients with diaphragmatic herniae. Six patients with congenital heart enlargement showed a poorly developed ipsilateral lung; 5 of 6 patients with dextrocardia without an intracardiac defect had a larger left lung compared with the right lung; both pulmonary beds appeared equal in a patient with mesocardia.

  12. [A new (?) multiple abnormality complex similar to the Poland syndrome].

    Science.gov (United States)

    Gugliantini, P; Saguì, L; Parri, C; Seganti, G; Cavalletti, P

    1984-01-01

    The report describes a case Poland's Syndrome - like in which the hypoplasia of the left major pectoralis muscle was associated with: subtotal aplasia of sternal body, severe hypoplasia of the ipsilateral scapula, humerus and forearm bones, tetradactyly in the ipsilateral hand, partial defect of the diaphragm with thoracic migration of the left hepatic lobe and secondary dextrocardia (false dextrocardia). Syndactyly was absent. The contribution is aimed to join out the radiological characteristics of the syndrome as well as the specific contribution provided in the case by Ultrasounds and aortography. Furthermore, the analysis of the case seems to indicate a strict relationship between the abnormalities of diaphragm, pectoralis muscle and homolateral upper limb.

  13. El síndrome de Kallmann. Correlación fenotipo-genotípica.

    OpenAIRE

    García Piñero, Alfonso José

    2015-01-01

    El Síndrome de Kallmann (SK) es una enfermedad genética del desarrollo, que asocia un hipogonadismo hipogonadotrópico (HH) congénito con pérdida total (anosmia) o parcial (hiposmia) del olfato. La alteración olfativa es secundaria a la aplasia o hipoplasia de las estructuras olfatorias (bulbos, tractos y surcos cerebrales olfatorios). El HH se debe a la deficiencia en la hormona liberadora de gonadotropinas hipotalámica (GnRH) como resultado del fallo en la migración de las neuronas productor...

  14. Congenital malformation of the vaginal orifice, imperforate vagina, in the common marmoset (Callithrix jacchus).

    Science.gov (United States)

    Niimi, Kimie; Oguchi, Ayaka; Nishio, Kenji; Okano, Yasushi; Takahashi, Eiki

    2015-03-01

    The following is a report on a congenital vaginal malformation, imperforate vagina, in the common marmoset (Callithrix jacchus). This anomaly was observed for the first time in an adult female in our research colony. There was no uterine and vaginal aplasia or atresia in her grossly normal genital tract. The plasma progesterone concentration suggested that the ovarian cycle had ceased. However, this may not be related to a functional anomaly, but rather to suppressed ovulation resulting from subordination to cagemates considering the various stages of follicular development observed.

  15. Sarcoidosis presenting with severe hypocalcaemia.

    LENUS (Irish Health Repository)

    Saeed, A

    2012-01-31

    Disorders of calcium metabolism, especially hypercalcemia and hypercalceuria, are common in sarcoidosis. They are caused by extra renal unsuppressed production of 1,25 dihydroxy vitamin D at the level of the sarcoid granuloma. Hormonal changes during pregnancy have a physiological synergistic effect on this mechanism, which is primarily parathyroid hormone (PTH) dependant. However, the combination of primary hypoparathyroidism with hypocalcemia and sarcoidosis is rare. Di George syndrome, is a dysmorphic disorder characterised by aplasia\\/hypoplasia of thymus and parathyroid glands in addition to aortic arch anamolies and facial dysmorphia. After commencing appropriate treatment this lady made excellent recovary.

  16. Unilateral agenesis of the abdominal wall musculature: An early muscle deficiency.

    Science.gov (United States)

    Gerard-Blanluet, Marion; Port-Lis, Marylin; Baumann, Clarisse; Perrin-Sabourin, Laurence; Ebrad, Patrick; Audry, Georges; Delezoide, Anne-Lise; Verloes, Alain

    2010-11-01

    Prune-belly sequence (PBS) usually results from early urethral obstruction. In rare cases, PBS seems to be due to a faulty primary development of the parietal mesenchyme leading to underdevelopment of the abdominal wall musculature, and disorganization of the smooth muscles in the urinary tract. We report on two patients with segmental, unilateral wall musculature deficiency associated with homolateral agenesis of ribs. One patient also had hemivertebrae and the other one ipsilateral diaphragmatic eventration and aplasia cutis. This combination of anomalies may represent a localized deficiency in the development of somitic mesoderm mesenchyme during early embryogenesis.

  17. SÍNDROME DE MAYER-ROKITANSKY-KÜSTER-HAUSER TIPO II: REPORTE DE UN CASO Y REVISIÓN DE OPCIONES TERAPÉUTICAS

    OpenAIRE

    Héctor Silva Cárcamo; José Luis Arita Erazo; Juan Carlos Fúnez

    2016-01-01

    El Síndrome de Mayer-Rokitansky-Küster-Hauser, es una anomalía poco frecuente, causada por aplasia de conductos de Müller, se caracteriza por ausencia congénita de vagina, alteraciones uterinas (variedad tipo I), acompañada de alteraciones renales y/o esqueléticas (variedad tipo II), con fenotipo femenino y función ovárica normal. Su incidencia es 1 en 4000-5000 mujeres. Caso clínico: Segundo caso reportado en Honduras, paciente femenina, 17 años de edad, acude por presentar amenorrea primar...

  18. TREATMENT OF 30 CASES OF INFANTILE HIGH FEVER WITH ERJIAN-POINT BLOOD-LETTING METHOD

    Institute of Scientific and Technical Information of China (English)

    李赛玲; 朱军

    2001-01-01

    High fever is referred to that the body temperature exceeds 39℃. Due to aplasia of the cerebral nerve system during infantile stage, continuous high fever may induce temporary functional disturbance of the brain, manifesting as sudden and transient loss of consciousness and local or general muscular spasm that is termed as infantile convulsion. The authors find in clinical practice that sometimes, administration of antipyretics as compound aspirin (APC), compound aminopyrine, etc. has no effect on infantile high fever, if treated with Erjian (MA-H 6) bleeding method, the body temperature may be decreased by 0.5~1.0℃. Here is the report.

  19. How many breaks do we need to CATCH on 22q11?

    Energy Technology Data Exchange (ETDEWEB)

    Dallapiccola, B.; Pizzuti, A.; Novelli, G. [Univ. of Rome, Rome (Italy)]|[Univ. of Milan (Italy)]|[CSS IRCCS Hospital, San Giovanni Rotondo (Italy)

    1996-07-01

    The major clinical manifestations of DiGeorge syndrome (DGS; MIM 188400), which reflect developmental abnormalities of the 3d and 4th pharyngeal pouch derivatives, include thymus- and parathyroid-gland aplasia or hypoplasia and conotruncal cardiac malformations. The additional dysmorphic facial features, such as hypertelorism, cleft lip and palate, bifid uvula, and small/low-set ears, which are also common, presumably reflect the same defect. The DGS phenotype has been associated with chromosome abnormalities and, sometimes, is the effect of teratogenic agents such as retinoic acid and alcohol. 53 refs., 1 fig.

  20. Chromosome 18q22.2-->qter deletion and a congenital anomaly syndrome with multiple vertebral segmentation defects.

    Science.gov (United States)

    Dowton, S B; Hing, A V; Sheen-Kaniecki, V; Watson, M S

    1997-05-01

    Multiple vertebral segmentation defects occur in a group of conditions variably associated with anomalies of other organ systems. This report describes a female child in whom a deletion of chromosome 18 (18q22.2-->qter) is associated with congenital anomalies including multiple vertebral segmentation defects resembling sporadic spondylocostal dysplasia. The child also has unilateral renal agenesis and unilateral fibular aplasia. The association of severe multiple vertebral segmentation defects with 18q- in this patient suggests the possibility that a gene important for somite formation or vertebral differentiation maps to this segment of chromosome 18.

  1. Evolutions et enjeux de la coopération internationale au développement

    Directory of Open Access Journals (Sweden)

    Gérard Perroulaz

    2010-03-01

    Full Text Available Le volume de l’aide publique au développement (APD fournie par les pays de l’OCDE atteint de nouveaux records. Les flux enregistrés au titre de l’APD incluent toutefois des catégories de dépenses qui ne concourent pas à l’objectif de réduction de la pauvreté dans les pays en développement. Les économies émergentes et les donateurs privés procurent une part croissante de l’aide. Des progrès ont été réalisés dans la mise en œuvre de la Déclaration de Paris sur l’efficacité de l’aide dans quelques domaines comme le déliement de l’aide, mais les résultats ne sont pas à la hauteur des attentes. L’approche demeure trop souvent techniciste et élude les dynamiques politiques qui ont une incidence majeure sur l’efficacité de l’aide. La question de la cohérence des politiques publiques au service du développement revient sur le devant de la scène, alors que les débats sur le changement climatique appellent à reconsidérer certains objectifs et stratégies des agences de coopération.

  2. Optimization of flight control parameters of an aircraft using genetic algorithms

    Science.gov (United States)

    Garcia Aguilar, Sixto Ernesto

    Ce travail presente de nouvelles methodes pour ameliorer la performance des algorithmes genetiques pour l'optimisation des gains du controleur d'un systeme de vol electrique des avions commerciaux. Nous avons combine les caracteristiques de deux operateurs de mutation, uniforme et non uniforme, au sein d'un nouvel operateur, de type periodique. Nous avons propose un nouveau modele avec contraintes et nous avons fait la conception d'un nouvel operateur de selection stochastique pour augmenter l'efficacite d'un algorithme genetique du codage reel (RGA) applique aux problemes d'optimisation avec contraintes. Pour la conception de l'operateur de selection sous contraintes, nous avons applique une methode qui peut manipuler la proportion d'individus faisables et non faisables sans negliger le comportement dynamique du GA. Finalement, nous avons reduit de 25% le temps d'execution original et ameliore l'efficacite des RGAs en combinant l'application d'un index de diversite d'une population d'un algorithme genetique ainsi qu'un reseau de Bayes (BN).

  3. L’Europe des lipides : enjeux et méthode

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    Parmentier Michel

    2000-03-01

    Full Text Available Ce n’est pas la première fois que les chercheurs et les industriels européens tentent de s’organiser dans le but de s’identifier et de se renforcer, face à la puissance et l’organisation du grand partenaire américain. L’AOCS (American oil chemists Society, dont tous les Européens connaissent l’efficacité et utilisent les services, possède en effet une image irremplaçable dans le secteur : ses journaux, ses congrès, sa présence dans l’ISF (International society for fat research, toute la communication « Lipides » qu’elle véhicule sont pour le chercheur européen une aide précieuse. Ce devrait être également pour tous une incitation à la fois forte et récurrente à une affirmation de l’identité et de l’autonomie du Vieux continent. Inconsciemment ou consciemment, comme dans de nombreux (pour ne pas dire tous domaines scientifiques et techniques, l’Amérique nous aiguillonne, nous impressionne, nous culpabilise dans notre atavique incapacité à monter dans le même train de l’efficacité et de la puissance affirmée.

  4. Mutations in KCTD1 cause scalp-ear-nipple syndrome.

    Science.gov (United States)

    Marneros, Alexander G; Beck, Anita E; Turner, Emily H; McMillin, Margaret J; Edwards, Matthew J; Field, Michael; de Macena Sobreira, Nara Lygia; Perez, Ana Beatriz A; Fortes, Jose A R; Lampe, Anne K; Giovannucci Uzielli, Maria Luisa; Gordon, Christopher T; Plessis, Ghislaine; Le Merrer, Martine; Amiel, Jeanne; Reichenberger, Ernst; Shively, Kathryn M; Cerrato, Felecia; Labow, Brian I; Tabor, Holly K; Smith, Joshua D; Shendure, Jay; Nickerson, Deborah A; Bamshad, Michael J

    2013-04-04

    Scalp-ear-nipple (SEN) syndrome is a rare, autosomal-dominant disorder characterized by cutis aplasia of the scalp; minor anomalies of the external ears, digits, and nails; and malformations of the breast. We used linkage analysis and exome sequencing of a multiplex family affected by SEN syndrome to identify potassium-channel tetramerization-domain-containing 1 (KCTD1) mutations that cause SEN syndrome. Evaluation of a total of ten families affected by SEN syndrome revealed KCTD1 missense mutations in each family tested. All of the mutations occurred in a KCTD1 region encoding a highly conserved bric-a-brac, tram track, and broad complex (BTB) domain that is required for transcriptional repressor activity. KCTD1 inhibits the transactivation of the transcription factor AP-2α (TFAP2A) via its BTB domain, and mutations in TFAP2A cause cutis aplasia in individuals with branchiooculofacial syndrome (BOFS), suggesting a potential overlap in the pathogenesis of SEN syndrome and BOFS. The identification of KCTD1 mutations in SEN syndrome reveals a role for this BTB-domain-containing transcriptional repressor during ectodermal development.

  5. Combined Use of Frontal Sinus and Nasal Septum Patterns as an Aid in Forensics: A Digital Radiographic Study

    Science.gov (United States)

    Verma, Pradhuman; Verma, Kanika Gupta; Khosa, Rameen; Kumar, Sandeep; Basavaraju, Suman; Patwardhan, Nitin

    2015-01-01

    Background: Skull radiographic examination is a potentially useful procedure for the personal identification in cases where fragments of skull persist with no likelihood of identification based on dental arch. Aims: The study was to determine the uniqueness and reliability of combined frontal sinus (FS) and nasal septum (NS) patterns as observed on posterioanterior (PA) cephalograms for personal identification. Materials and Methods: The randomly selected 149 digital PA cephalograms taken on Kodak 8000C Digital Panoramic and Cephalometric system were evaluated for patterns of FS and NS. Also the distribution of lobulations, area, and ratio of height/width of FS was calculated. The data obtained was statistical analyzed using Pearson's coefficient correlation. Results: FS symmetry was observed in 78.5% and asymmetry in 7.3% subjects. Bilateral aplasia was noticed in 5.3% and unilateral aplasia in 8.7% of subjects. The total lobulation of FS was noted more in males on both sides while center lobes were observed slightly more in females. The straight NS was maximally seen followed by reverse sigmoid. The mean ratio of width/height of FS was observed more in males and highly significant correlation was observed with both sexes. The mean area of FS was noted more in males. There was significant correlation found between patterns of NS and FS except in right dominated asymmetrical FS. Conclusion: The combined use of FS and NS patterns could be used as method for identification by exclusion in forensics. PMID:25789248

  6. Combined use of frontal sinus and nasal septum patterns as an aid in forensics: A digital radiographic study

    Directory of Open Access Journals (Sweden)

    Pradhuman Verma

    2015-01-01

    Full Text Available Background: Skull radiographic examination is a potentially useful procedure for the personal identification in cases where fragments of skull persist with no likelihood of identification based on dental arch. Aims: The study was to determine the uniqueness and reliability of combined frontal sinus (FS and nasal septum (NS patterns as observed on posterioanterior (PA cephalograms for personal identification. Materials and Methods: The randomly selected 149 digital PA cephalograms taken on Kodak 8000C Digital Panoramic and Cephalometric system were evaluated for patterns of FS and NS. Also the distribution of lobulations, area, and ratio of height/width of FS was calculated. The data obtained was statistical analyzed using Pearson′s coefficient correlation. Results: FS symmetry was observed in 78.5% and asymmetry in 7.3% subjects. Bilateral aplasia was noticed in 5.3% and unilateral aplasia in 8.7% of subjects. The total lobulation of FS was noted more in males on both sides while center lobes were observed slightly more in females. The straight NS was maximally seen followed by reverse sigmoid. The mean ratio of width/height of FS was observed more in males and highly significant correlation was observed with both sexes. The mean area of FS was noted more in males. There was significant correlation found between patterns of NS and FS except in right dominated asymmetrical FS. Conclusion: The combined use of FS and NS patterns could be used as method for identification by exclusion in forensics.

  7. Prenatal Diagnosis of Bilateral Ectrodactyly and Radial Agenesis Associated with Trisomy 10 Mosaicism

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    Jonathan Lévy

    2013-01-01

    Full Text Available Ectrodactyly or split hand and foot malformations (SHFMs are rare malformations of the limbs, characterized by median clefts of the hands and feet, syndactyly, and aplasia and/or hypoplasia of the phalanges. They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. Bilateral radial ray defects comprise also a large heterogenous group of disorders, including trisomy 18, Fanconi anemia, and thrombocytopenia-absent-radius syndrome, not commonly associated with ectrodactyly. The present paper describes a case of ectrodactyly associated with bilateral radial ray defects, diagnosed in the first trimester of pregnancy, in a fetus affected by trisomy 10. Only four cases of sporadic and isolated ectrodactyly, diagnosed by ultrasonography between 14 and 22 weeks’ gestation, have been reported. To our knowledge, the present case is the first report of mosaic trisomy 10 associated with SHFM and radial aplasia. Trisomy 10 is a rare lethal chromosomal abnormality, most frequently found in abortion products. Only six liveborn mosaic trisomy 10 infants, with severe malformations, dead in early infancy, have been reported. A severe clinical syndrome can be defined, comprising ear abnormalities, cleft lip/palate, malformations of eyes, heart, and kidneys, and deformity of hands and feet and most often associated with death neonatally or in early infancy.

  8. Impact of anatomical variations of the circle of Willis on the incidence of aneurysms and their recurrence rate following endovascular treatment

    Energy Technology Data Exchange (ETDEWEB)

    Songsaeng, D. [Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto (Canada); Department of Radiology, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok (Thailand); Geibprasert, S.; Willinsky, R. [Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto (Canada); Tymianski, M. [Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto (Canada); TerBrugge, K.G. [Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto (Canada); Krings, T., E-mail: timo.krings@uhn.on.c [Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto (Canada)

    2010-11-15

    Aim: To analyse the impact of anatomical variations of the parent arteries on the incidence and recurrence rate following coil embolization of aneurysms of the anterior (AcoA), posterior communicating artery (PcoA) and basilar artery (BA) tip. Methods: Two hundred and two (96 AcoA, 67 PcoA, and 29 BA) aneurysms in 200 patients were treated with coil embolization between January 2000 and April 2008. Parent artery variations at each location were classified as: AcoA: A1 aplasia versus hypoplasia versus symmetrical size; PcoA: foetal origin versus medium versus small size, BA: cranial versus caudal versus asymmetrical fusion. The incidence of aneurysms and difference between recurrence rates for each group were recorded on follow-up. Results: AcoA, PcoA, and BA aneurysms were more often associated with embryonically earlier vessel wall dispositions (A1 aplasia, foetal PcoA, asymmetrical fusion). Two of these variations were also associated with aneurysm recurrence following coil embolization: asymmetrical A1 segment (p = 0.01), and asymmetrical BA tip (p = 0.02). Conclusions: AcoA, PcoA, and BA tip aneurysms tend to occur more often in anatomically variant parent artery dispositions, some of which are related to aneurysm recurrence following coil embolization. This may relate to a more fragile vessel disposition as it is not fully matured or to altered haemodynamics secondary to the anatomical variations.

  9. Infecção por Chryseobacterium indologenes: relato de um caso Chryseobacterium indologenes infection: a case report

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    Renata de Souza Ferreira

    2010-03-01

    Full Text Available Relatamos um caso de infecção por Chryseobacterium indologenes, presente na cultura de aspirado traqueal em paciente sob ventilação mecânica invasiva, revisando os aspectos epidemiológicos, microbiológicos e o tratamento na unidade de terapia intensiva. Paciente do sexo masculino, 30 anos, internado com quadro de aplasia de medula idiopática e neutropenia febril foi transferido para a unidade de terapia intensiva com quadro de broncopneumonia e sepse grave de origem pulmonar. A maioria dos casos já relatados de pacientes com infecção por Chryseobacterium indologenes apresentavam patologias graves associadas e infecções polimicrobianas que podem dificultar a interpretação da efetividade da terapia antimicrobiana contra este agente.A case of Chryseobacterium indologenes infection is reported, identified in an invasive mechanic ventilation patient's tracheal aspiration material. Epidemiological, microbiological, and intensive care unit therapy aspects are discussed. The patient was a 30 years-old male, admitted with idiopathic medullary aplasia and febrile neutropenia, referred to the intensive care unit with severe bronchopneumonia and sepsis of pulmonary origin. Most of the previously reported Chryseobacterium indologenes infection cases were associated with severe diseases and polymicrobial infections which could make difficult interpreting antimicrobial therapy options against this agent.

  10. SÍNDROME DE MAYER-ROKITANSKY-KÜSTER-HAUSER TIPO II: REPORTE DE UN CASO Y REVISIÓN DE OPCIONES TERAPÉUTICAS

    Directory of Open Access Journals (Sweden)

    Héctor Silva Cárcamo

    2016-07-01

    Full Text Available El Síndrome de Mayer-Rokitansky-Küster-Hauser, es una anomalía poco frecuente, causada por aplasia de conductos de Müller, se caracteriza por ausencia congénita de vagina, alteraciones uterinas (variedad tipo I, acompañada de alteraciones renales y/o esqueléticas (variedad tipo II, con fenotipo femenino y función ovárica normal. Su incidencia es 1 en 4000-5000 mujeres. Caso clínico: Segundo caso reportado en Honduras, paciente femenina, 17 años de edad, acude por presentar amenorrea primaria, dolor pélvico intenso, sin atenuantes coincidiendo una vez al mes. Al examen físico encontramos presentes características sexuales secundarias, genitales femeninos externos normales, ausencia total del conducto vaginal que imposibilita realizar tacto vaginal. Se realizan estudios de imagen como USG, pielograma intravenoso reportando: útero didelfo infantil y ectopia renal. La laparotomía exploratoria revela alteraciones renales y trompas rudimentarias. Discusión: El tratamiento indicado es la colpopoiesis o neovagina con diferentes métodos quirúrgicos o no quirúrgicos para el completo desarrollo sexual y psicológico de la paciente. Palabras Clave: Amenorrea, conductos de Müller, Aplasia

  11. CT myelography characteristics of spinal dysraphism in a young mixed breed dog Características de mielografía con TC de una disrafia espinal en un perro mestizo joven

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    M Gómez

    2012-01-01

    Full Text Available Spinal dysraphism is a congenital defect of the vertebral column and spinal cord secondary to imperfect closure of the caudal neuropore of the developing neural tube. This report describes computed tomographic myelography (Myelo-CT characteristics of spina bifida occulta, spinal cord aplasia/hypoplasia and split cord malformation type II (diplomyelia in the caudal lumbar area of a 2 month old mixed breed dog.La disrafia espinal es un defecto congénito de la columna vertebral y la médula espinal secundaria a un cierre imperfecto del neuroporo caudal del tubo neural en desarrollo. Este reporte describe las características observadas en una mielografía por tomografía computarizada (mielo-TC de una espina bífida oculta, aplasia/hipoplasia segmentaria de médula espinal y duplicación de médula espinal tipo II (diplomielia en el segmento lumbar caudal de un perro mestizo de dos meses de edad.

  12. Pectus excavatum, pectus carinatum and other forms of thoracic deformities

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    Saxena Amulya

    2005-01-01

    Full Text Available This review article covers the spectrum of congenital thoracic wall deformities along with their historical background. Willital′s classification divides these deformities into 11 types - funnel chest (4 types, pigeon chest (4 types, and combination of funnel and pigeon chest, chest wall aplasia and cleft sternum. Records of patients at our center comprised 90% depression deformities, 6% protrusion deformities, 3% combined depression-protrusion deformities and 1% other forms. Mild forms of abnormalities warrant the wait- and-watch approach during the first 4-5 years. The deformities manifest primarily during the pubertal spurt often with rapid progression with subjective complaints like dyspnea, cardiac dysthesia, limited work performance and secondary changes. Operative correction in young adults is more favorable in mild cases. The Willital technique has been the standard technique for the correction of pectus excavatum, pectus carinatum and other combined forms of deformities at our center with excellent long term results. The Nuss procedure and the Pectus Less Invasive Extrapleural Repair (PLIER technique for pectus excavatum and pectus carinatum have also been described in this article. Surgical correction for Poland′s syndrome is reserved for patients with severe aplasia of the ribs with major depression deformity. Sternal defects including various types of ectopia cordis are discussed. Even after surgical correction, there is significant reduction in the total capacity and inspiratory vital capacity of the lungs, probably a result of the decreased compliance of the chest wall. However, the efficiency of breathing at maximal exercise improves significantly after operation.

  13. Expanding the phenotype of 22q11 deletion syndrome: the MURCS association.

    Science.gov (United States)

    Uliana, Vera; Giordano, Nicola; Caselli, Rossella; Papa, Filomena Tiziana; Ariani, Francesca; Marcocci, Claudio; Gianetti, Elena; Martini, Giuseppe; Papakostas, Panagiotis; Rollo, Fabio; Meloni, Ilaria; Mari, Francesca; Priolo, Manuela; Renieri, Alessandra; Nuti, Ranuccio

    2008-01-01

    The MURCS association [Müllerian Duct aplasia or hypoplasia (M), unilateral renal agenesis (UR) and cervicothoracic somite dysplasia (CS)] manifests itself as Müllerian Duct aplasia or hypoplasia, unilateral renal agenesis and cervicothoracic somite dysplasia. We report on a 22-year-old woman with bicornuate uterus, right renal agenesis, C2-C3 vertebral fusion (MURCS association) and 22q11.2 deletion. Angio-MRI revealed the aberrant origin of arch arteries. Hashimoto thyroiditis, micropolycystic ovaries with a dermoid cyst in the right ovary and mild osteoporosis were also diagnosed. Accurate revision of radiographs enabled us also to identify thoracolumbar and lumbosacral vertebral-differentiation defects. Audiometry and echocardiogram were normal. Bone densitometry showed osteoporosis. As per our evaluation, the patient had short stature, obesity (BMI 30.7) and facial features suggestive of the 22q11 deletion syndrome. Multiplex ligation-dependent probe amplification analysis showed a de-novo 22q11.2 deletion confirmed by array-comparative genomic hybridization analysis. We discuss whether this is a casual association or whether it is an additional syndrome owing to the well known phenotype extensive variability of the 22q11 deletion syndrome.

  14. Ectrodactilia em cão (Canis domestica Ectrodactilia in dog (Canis domestica

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    Daniela Oliveira

    2002-12-01

    Full Text Available O presente trabalho relata o caso de uma cadela sem raça definida, adulta, com deformidade na região distal do membro torácico esquerdo, a qual consistia de duplicidade do osso acessório do carpo, aplasia do primeiro carpiano, ausência dos ligamentos interósseos entre o terceiro e o quarto dígitos, alterações ósseas no quarto dígito e presença de um dígito supranumerário incompleto adjacente ao quarto dígito. Após análise dos defeitos concluiu-se tratar de uma malformação congênita, hereditária em cães, denominada ectrodactilia, associada à existência de um dígito supranumerário.This paper describes a case of an adult mongrel bitch with a deformity in the distal area of the left forelimb, which was based on duplicity of the accessory carpal bone, aplasia of the first carpal bone, nonexistence of the interosseus ligament between digits 3 and 4, bony alterations in digit 4 and presence of an incomplete supernumerary digit adjacent to digit 4. After analysis of defects it was concluded to be a hereditary congenital malformation named ectrodactyly, associated to the existence of a supernumerary digit.

  15. MURCS association and anorectal malformation: Case report of a female newborn

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    Sofia Morão

    2017-03-01

    Full Text Available MURCS association is rare, first described by Duncan et al. in 1979, including Müllerian duct aplasia, renal aplasia and cervicothoracic somite dysplasia. Levitt and Peña described in 2007 a classification of syndromic anorectal malformation (ARM that associates these two entities. The reported case is the first one described in neonatal period. We describe a case of a female newborn with suspected diagnosis of anorectal and renal malformations. Physical and radiologic investigation revealed agenesis of sacrum and coccyx, tethered cord, left multicystic renal dysplasia, absence of vaginal orifice and hymen, normally placed urethral orifice and abnormal anal opening at the vaginal introitus as a rectovestibular type fistula. Also, she had right uterine, tube and ovary agenesis with a normal 46, XX female karyotype. A left diversing colostomy was done in first day of life and four months later, was performed a posterior sagittal anorectoplasty (PSARP, with intra-operative identification of a duplication of the distal rectum (related with caudal regression syndrome type 2. There were no complications in postoperative period. A staged management strategy is a viable option avoiding further complications in an already poor prognosis situation.

  16. Você conhece esta síndrome? Do you know this syndrome?

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    Maurício Pedreira Paixão

    2007-06-01

    Full Text Available A síndrome oculoauriculovertebral, mais comumente conhecida como síndrome de Goldenhar, pode ser diagnosticada pelo dermatologista. Achados como hipoplasia/aplasia de pavilhão auricular e alterações vertebrais, e a presença de trago acessório encontrados no paciente são elementos-chave para a suspeita da síndrome. Sua identificação é de suma importância dada a possibilidade de outras alterações sistêmicas, com impacto até no prognóstico do paciente. Após a confirmação diagnóstica, é interessante a abordagem multidisciplinar e integral em função da potencial pluralidade de manifestações que podem ocorrer na síndrome.The Oculoauriculovertebral Syndrome, more commonly known as the Goldenhar Syndrome, can be diagnosed by the dermatologist. Findings such as hypoplasia/aplasia of the auricular pavilion, vertebral alterations and accessory tragi are the key elements for the suspicion of the syndrome. Its identification is of utmost importance, given the possibility of other systemic alterations, with impact also on the patient's prognosis. After confirmation of the diagnosis, an integral and multidisciplinary attention is important, because of the plurality of manifestations that can occur in the syndrome.

  17. Você conhece esta síndrome? Do you know this syndrome?

    Directory of Open Access Journals (Sweden)

    Fernanda Assis Ottoni

    2006-10-01

    Full Text Available Descreve-se caso de anemia de Fanconi com manifestações cutâneas típicas de hiperpigmentação difusa e manchas café-com-leite. Apresentava ainda hipoplasia de polegar, baixa estatura, catarata, hipoacusia, rins pélvicos e quebras cromossômicas. Atualmente com 30 anos, o paciente se mantém estável, com leucopenia e macrocitose sem repercussão clínica, contrariando o prognóstico da síndrome, usualmente letal em idade precoce, por complicações de aplasia de medula, leucemia e tumores sólidos.A case of Fanconi anemia is reported, with typical cutaneous manifestations of diffuse hyperpigmentation and café-au-lait spots. He also presented thumb hypoplasia, short stature, cataract, hypoacusis, pelvic kidneys and chromosome breakage. Presently 30-years-old, the patient is stable, with leukopenia and macrocytosis without clinical symptoms, in contrast to usual prognosis of this syndrome, which involves early death due to complications of bone marrow aplasia, leukemia and solid tumors.

  18. Parvovirus-B19 and hematologic disorders

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    Sevgi Yetgin

    2010-12-01

    Full Text Available Parvovirus-B19 (PV-B19 is a member of Parvoviridae, which is one of the smallest DNA viruses. PV-B19-associated diseases usually serve as a good representation of the balance of virus, host response and the immune system. The diseases manifested with PV-B19 are erythema infectiosum, which is common in children, hydrops fetalis, transient pure red cell aplasia in patients with chronic hemolytic anemia, arthralgia - mostly observed in women, and chronic pure red cell aplasia in immunocompromised individuals. Cytopenia (bicytopenia, monocytopenia or pancytopenia may also accompany the diseases mentioned above. On the other hand, there are many diseases, including neurologic, vasculitic, hepatic, rheumatoid, nephritic, autoimmune, myocardial, and others in which the mechanisms of the diseases are not clear, which may be associated with PV-B19. The virus may manifest with unexpected and unexplained clinical pictures and lead to misdiagnosis. Therefore, hematologic disorders in any unestablished clinical diagnosis should be investigated for PV-B19 infection. However, serologic examination for PV-B19 diagnosis is not sufficient in immunocompromised status. The virus can be determined with polymerase chain reaction (PCR in the serum or tissue samples. Supportive therapy, blood transfusion and immunoglobulin are the conventional therapeutic interventions for PV-B19 today. Vaccination studies are under examination.

  19. Les médicaments à libération prolongée pour les enfants et les adolescents ayant un trouble de déficit de l’attention avec hyperactivité

    Science.gov (United States)

    Feldman, M; Bélanger, S

    2009-01-01

    Le trouble de déficit de l’attention avec hyperactivité (TDAH) touche un enfant canadien sur 20 et s’associe à un dossier scolaire et à un registre d’emploi défavorables, à des taux élevés de blessures et de consommation de drogues ou d’alcool, à des relations interpersonnelles médiocres, à de mauvaises issues en santé mentale et à une qualité de vie insatisfaisante. Des essais contrôlés démontrent que les médica-ments sont efficaces pour traiter les symptômes de TDAH tandis que des études d’observation indiquent qu’ils s’associent à de meilleures issues sociales et de santé. De nombreuses familles, ainsi que leur médecin traitant, préfèrent les médicaments à libération prolongée (LP) contre le TDAH aux médicaments à libération immédiate (LI) et à action brève. Toutefois, les préparations à LP sont souvent inabor-dables pour les familles, dont un nombre disproportionné fait partie de la strate à faible statut socioéconomique. Le présent document de principes vise à proposer une évaluation critique des données probantes sur l’efficacité relative des médicaments à LP par rapport aux médicaments à LI ainsi que des recommandations au sujet de leur utilisation convenable dans le traitement du TDAH. Lorsque les médicaments sont indiqués, il faut envisager d’utiliser des préparations à LP comme traitement de première intention contre le TDAH parce qu’elles sont plus efficaces et moins susceptibles d’être détournées. Les futures recherches et les analyses coûts-avantages doivent tenir compte à la fois de l’efficacité de médicaments dans des études contrôlées et de leur efficacité clinique en situation réelle ainsi que du potentiel de détournement et de mésusage de ces médicaments. L’industrie, les sociétés d’assurance et le gouvernement doivent collaborer pour rendre ces médicaments accessibles à tous les enfants et adolescents ayant un TDAH.

  20. SOS français : Conception et évaluation d’un didacticiel d’aide à la rédaction interactif

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    Gerard Laetitia

    2012-07-01

    Full Text Available L’objectif de la présente contribution est double. D’une part, nous présentons un nouveau didacticiel d’aide à la rédaction destiné à des apprenants de français langue étrangère ou seconde, SOS français, que nous situons par rapport aux correcteurs orthographiques et grammaticaux existants. SOS français fournit un contrôle de texte axé sur les principaux items orthographiques, grammaticaux et lexicaux réputés difficiles et sources d’erreurs fréquentes et récurrentes. Il se caractérise par un feedback très développé destiné à aider les apprenants à développer leurs compétences langagières. Une description grammaticale est également intégrée. Un deuxième volet de notre contribution est consacré à une étude d’efficacité. Nous y posons trois questions de recherche, portant sur l’efficacité de SOS français lors de la correction de textes, sur l’impact que peut avoir un tel outil sur la maîtrise du français à court et à moyen terme et sur la corrélation entre l’efficacité de l’aide et le type d’item grammatical. Nous avons pour cela mis en place une étude auprès de quelque 200 étudiants de première année universitaire. Dans la contribution, nous présentons la méthodologie suivie et les tout premiers résultats de cette étude, qui montrent l’intérêt de ce type d’outil tout en confirmant les constatations faites dans d’autres études quant à la difficulté de corriger les problèmes de grammaire.

  1. Rôle des additifs anti-usure des huiles lubrifiantes dans un teste de frottement simulant le contact segment-chemise Role of Antiwear Additives for Lube Oils in a Friction Test Simulating Ring-Liner Contact

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    Martin J. M.

    2006-11-01

    Full Text Available Nous avons mis en oeuvre un test de frottement dans lequel les conditions tribologiques sont voisines de celles existant au niveau segment-chemise des moteurs à explosion. Nous avons éprouvé différentes huiles commerciales ainsi que des additifs purs. Ayant choisi la température comme paramètre variable au cours de ce test nous pouvons déterminer pour chaque lubrifiant une plage de température correspondant à une zone d'efficacité maximale de l'additif anti-usure qu'il contient. La température correspondant à la limite inférieure de cette plage est liée à la nature chimique de l'additif. De plus lorsqu'un gradient de température existe entre les deux pièces en frottement, on observe, dans la zone d'efficacité maximale du lubrifiant, un phénomène de pulsations verticales de la goutte d'huile placée dans le contact. Des éléments d'interprétation, expliquant ces deux phénomènes, sont proposés et conduisent à relier l'efficacité anti-usure d'un additif à ses propriétés d'adsorption à la surface des pièces frottantes. The tribological conditions in the test used were similar to these existing in the ringliner area. of explosion engines. Different commercial cils were tested along with pure additives. Since temperature was chosen as a variable parameter during these tests, it was possible to determine a temperature range for each lubricant, corresponding to the maximum efficiency zone for the antiwear additive it contained. The temperature corresponding to the lower limit of this range is linked to the chemical nature of the additive. Likewise, when a temperature gradient exists between two rubbing parts, a vertical pulsation phenomenon of the drop of cil n the contact area occurs in the maximum efficiency zone of the lubricant. Interpretation elements explaining these two phenomena are proposed and lead to linking the antiwear efficiency of an additive to its adsorption properties on the surface of rubbing parts.

  2. Inhibition de la corrosion d'acier au carbone en milieu H3PO4 2M par des composés organiques de type ``triazine''

    Science.gov (United States)

    Bekkouch, K.; Aouniti, A.; Hammouti, B.; Kertit, S.

    1999-05-01

    The effect of addition of some triazine compounds on the corrosion behaviour of steel in 2M H3PO4 has been studied by weight loss and electrochemical polarisation methods. Both methods showed that the dissolution rate was dependent on the chemical properties and concentration of the product. From comparison of results, it was found that 6-azathymine (T6) is the best inhibitor and its inhibition efficiency reaches a maximum value of 86% at 10-3 M. Polarisation measurements indicated that T6 acts as cathodic inhibitor by merely blocking the reaction sites without changing the mechanism of the hydrogen evolution reaction. It was found that T6 was adsorbed on steel surface according to a Langmuir isotherm model. The effect of temperature indicated that inhibition efficiency of T6 is dependent on the temperature in the range 25-50 circC. L'effet de l'addition de certains composés organiques de type triazine sur la corrosion d'un acier en milieu H3PO4 2M a été étudié à l'aide des méthodes électrochimiques et gravimétriques. Les résultats obtenus ont montré que la vitesse de dissolution de l'acier dépend de la structure moléculaire et de la concentration du produit. La comparaison des efficacités inhibitrices montre que le 6-azathymine (T6) est le meilleur inhibiteur de la série des triazines testés. L'efficacité inhibitrice du T6 atteint une valeur maximale de 86 % à 10-3 M. L'allure des courbes de polarisation indique que le T6 agit essentiellement comme inhibiteur de type cathodique par adsorption à la surface de l'acier selon le modèle de l'isotherme de Langmuir. L'efficacité inhibitrice du T6 dépend de la température dans le domaine allant de 25 à 50 circC.

  3. Fiabilité intra- et inter-examinateur du dynamomètre MicroFET2 pour la flexion et l'extension du genou: une étude transversale avec répétition des mesures

    OpenAIRE

    Indermühle, Caroline; Henguely, Dunja; Mittaz Hager, Anne-Gabrielle

    2016-01-01

    L’évaluation de la force musculaire est un élément essentiel de la prise en charge physiothérapeutique. Le testing manuel se révèle subjectif et peu précis pour quantifier la force lorsqu’elle est élevée. L’objectivité est pourtant nécessaire et dépend de la qualité des mesures. Les dynamomètres manuels, tels que le microFET2 ont été développés afin de démontrer l’efficacité des traitements de manière objective. Notre objectif est donc de conduire une étude, avec un protocole standardisé...

  4. Evaluation du coût de la prise en charge des enfants infectés par le VIH à Abidjan (Côte d'Ivoire) en 1996-1997

    OpenAIRE

    Giraudon, I; Leroy, V.; Msellati, Philippe; Elenga, N.; Ramon, R.; C. Welffens-Ekra; Dabis, F.

    1999-01-01

    Le coût de la prise en charge d'un enfant infecté par le VIH en Afrique est mal connu mais cette variable doit être prise en compte dans les analyses coût-efficacité des stratégies visant à réduire la transmission verticale du VIH. L'objectif de ce travail était de mesurer, à Abdijan (Côte d'Ivoire), le coût direct de la prise en charge médicale pendant leur première année de vie des enfants nés de mères infectées par le VIH1 (VIH+) et d'estimer le surcoût lié à l'infection pédiatrique à VIH ...

  5. De l’intérêt croissant des bailleurs humanitaires pour l’environnement

    OpenAIRE

    Renaudin, Blanche

    2014-01-01

    Une étude portant sur l’intégration de l’environnement dans le secteur humanitaire a été commanditée par l’une des coordinations stratégiques des bailleurs humanitaires, la Good Humanitarian Donorship Initiative (GHDI), en prévision de la définition de son plan d’action pour l’amélioration de la qualité et de l’efficacité des actions humanitaires. Cette commande témoigne d’une prise de conscience forte et collective de la part des bailleurs humanitaires quant à la nécessité de mieux intégrer ...

  6. La sécurité des humanitaires en question

    OpenAIRE

    Vinhas, Stéphane

    2014-01-01

    La sécurité est devenue une donnée incontournable dans la mise en place des missions d’aide internationale. Mais lorsque l’action humanitaire est empêchée ou menacée, comment assurer son efficacité et sa qualité ? Comment répondre à ce dilemme de l’éthique humanitaire ? Longtemps volontaire sur le terrain puis salarié au siège de Médecins du Monde, Stéphane Vinhas partage ici ses expériences et réflexions personnelles sur ce sujet. Nombre de penseurs ont théorisé une vision pessimiste de l’Ho...

  7. L’humanitaire à venir

    OpenAIRE

    Ahmed, Manzoor; Arki, Annabelle; Benboubetra, Sonia; Bernard, Olivier; Boinet, Alain; Collette, Pauline; Corty, Jean-François; Costantinos, Berhe Tesfu; David, Bruno; Denormandie, Ninon; Donini, Antonio; Eloy, David; Gallien, Pierre; Luminet, Béatrice; Persichino, Roger

    2010-01-01

    Presque 40 ans après le lancement de l’aventure « French doctors » pour faire face aux crises naturelles ou provoquées par l’homme, des progrès importants ont été réalisés en matière d’efficacité de l’aide aux populations, par exemple dans les domaines de la santé nutritionnelle, de la mortalité infantile ou du sida. Pour autant, il nous faut appréhender avec lucidité les changements qui ont accompagné le développement du champ humanitaire. Dans le contexte de reconfiguration géostratégique n...

  8. Améliorer une présentation PowerPoint - Étude de l’impact d’une formation sur la qualité de 10 diaporamas

    OpenAIRE

    Clémence Feyens; Dominique Verpoorten

    2005-01-01

    [Français] Ce texte décrit un dispositif de formation visant l’amélioration des présentations PowerPoint. Mis en œuvre par le LabSET (Université de Liège) pour une importante agence de la Commission européenne, il a donné lieu, à son démarrage et à son terme, à un audit approfondi de 10 diaporamas (346 diapositives). La grille d’évaluation utilisée réinvestit les travaux de S. Villeneuve (2004) tels que décrits dans l’article « Les logiciels de présentation en pédagogie. Efficacité de l’utili...

  9. Reconstruction du ligament croisé antérieur et entraînement neuromusculaire

    OpenAIRE

    Cruchon, Alexandra; Samin, Christophe; Balthazard, Pierre

    2014-01-01

    Introduction La rupture du ligament croisé antérieur (LCA) est une blessure très fréquente nécessitant régulièrement une intervention chirurgicale. L’entrainement neuromusculaire fait partie intégrante de la prise en charge du physiothérapeute lors d’une reconstruction du LCA. De nombreuses études ont mis en évidence son efficacité, cependant, peu d’études s’intéressent aux modalités d’application et plus précisément au moment où il doit être entrepris. Ce travail de bachelor a pour objectif ...

  10. Jean-Marc Lorach, Etienne de Quatrebarbes, 2002, Guide du territoire durable – L’Agenda 21 territorial pour les collectivités locales et leurs partenaires, Pearson Education France, Paris, 416 P.

    Directory of Open Access Journals (Sweden)

    Bertrand Zuindeau

    2003-09-01

    Full Text Available Les Agendas 21 locaux proposés dès 1992 dans le cadre du Sommet de la Terre, mais dont la mise en œuvre s’est opérée assez tardivement en France, ont suscité deux types de littératures : d’une part, des ouvrages d’évaluation qui s’intéressent aux conditions de réalisation de cet outil territorial de développement durable et à son efficacité d’ensemble ; d’autre part, des contributions porteuses de méthodes d’aide à l’élaboration d’Agendas 21 locaux. C’est probablement dans ce second registre ...

  11. Le zona ophtalmique: une dermatose rare chez l'enfant

    Science.gov (United States)

    Zakia, Douhi; Meziane, Marieme; Salim, Gallouj; Zahra, Mernissi Fatima

    2015-01-01

    Le zona est dû a une réactivation du virus varicelle-zona (VZV) qui reste quiescent dans les ganglions sensitifs dorsaux après la varicelle. Le zona de l'enfant est rare et particulièrement la forme ophtalmique, qui peut être responsable de complications oculaires graves nécessitant une prise en charge adéquate et précoce. Il est parfois associé à des douleurs post-zostériennes dont le traitement est difficile. L'aciclovir per os administré dans les 72 heures après l’éruption a prouvé son efficacité dans la prévention des complications oculaires. Nous en rapportant un nouveaux cas chez un garçon immunocompétent de 9 ans, sans notion de varicelle antérieure. PMID:26955408

  12. Influence of radiation dose distribution in radiobiological modifications after Gamma Knife radiosurgery

    OpenAIRE

    Massager, Nicolas

    2008-01-01

    La radiochirurgie par Gamma Knife constitue une modalité thérapeutique reconnue de certaines affections cérébrales. Le traitement se base sur l’administration d’un rayonnement focalisé au niveau d’une cible intracrânienne. L’efficacité de ce traitement repose sur la délivrance d’une dose d’irradiation efficace au sein d’un volume-cible associé à la délivrance d’une dose d’irradiation négligeable à l’extérieur de ce même volume-cible. En pratique, la dose d’irradiation administrée à l’intérieu...

  13. Analytical development and traceability in food chemistry: examples of application to Swiss and foreign Emmental cheese

    OpenAIRE

    Pillonel, Laurent; Tabacchi, Raphaël

    2004-01-01

    La présente thèse de doctorat est divisée en quatre parties principales. Dans la première partie, la problématique de la préconcentration des composés volatils est traitée de manière à étendre le champ d'application des nez électroniques (ENs). Un article de revue fait ressortir les avantages des techniques à équipement portatif telles que la micro-extraction en phase solide (SPME) et l'extraction dynamique en phase solide (SPDE). Toutes deux ont montré une efficacité comparable avec l'équipe...

  14. Effets d´un entraînement informatisé sur la compréhension en lecture des élèves de 11- 12 ans

    OpenAIRE

    Goumi, Antonine; Rouet, Jean-François; Maniez, Audrey

    2007-01-01

    International audience; L´objectif de cette étude est d´évaluer l´efficacité d´un environnement informatisé, le système LIRALEC, pour l´entraînement des capacités de compréhension en lecture des élèves de Sixième (11-12 ans). LIRALEC a été conçu en référence aux théories psycholinguistiques de la lecture et de la compréhension. Il comporte plusieurs scénarios d´exercices visant à favoriser la production d´inférences et le contrôle de la compréhension. Les élèves d´un collège expérimental ont ...

  15. Audit énergétique du Centre sportif de Combremont de la commune de Riddes

    OpenAIRE

    Briguet, Lionel; Genoud, Stéphane

    2016-01-01

    L’objectif de ce travail est la réalisation d’un audit énergétique du Centre sportif de Combremont à Riddes. Le but étant d’analyser les consommations électriques et thermiques de l’établissement en vue d’apporter des recommandations d’amélioration de l’efficacité énergétique. Tout d’abord, une analyse de l’éclairage du site sera effectuée. Puis, les déperditions thermiques de l’enveloppe de la bâtisse seront déterminées. Une observation des différentes installations techniques sera fait...

  16. Inegalites sociales et scolaires dans l’enseignement agricole

    OpenAIRE

    Minassian, Laure

    2015-01-01

    Les formations par alternance sont souvent invoquées pour faire réussir des élèves en échec dans les dispositifs plus classiques. Mais leurs effets sont-ils ceux escomptés ? Deux écoles qui relèvent de deux systèmes pédagogiques d’alternance dans l’enseignement agricole sont comparés. L’analyse comparative est centrée sur les productions écrites de ces derniers en début et en fin de formation. Les résultats de l’enquête remettent en cause la croyance en l’efficacité de certains dispositifs re...

  17. Combinação de adsorção por carvão ativado com Processo Oxidativo Avançado (POA) para tratamento de efluentes contendo fenol

    OpenAIRE

    Muranaka, Cínthia Tiemi

    2010-01-01

    L'adsorption sur charbon actif est une technique relativement répandue de post-traitement des effluents aqueux. Cependant il ne s'agit pas d'un traitement ultime, puisque les polluants restent concentrés sur la surface solide. Des techniques de régénération doivent donc être mises en œuvre. C'est dans ce contexte qu'ont été étudiés ici les procédés d'oxydation avancée Fenton et photo-Fenton, dont l'efficacité est reconnue pour éliminer la pollution organique. Plus précisément, l'objet de cett...

  18. L'effet coup de fouet dans la chaîne logistique : une littérature contingente et incomplète

    OpenAIRE

    Giard, Vincent; Sali, Mustapha

    2012-01-01

    L'effet coût de fouet (ECF) correspond au phénomène d'amplification croissante de la variabilité de la demande en remontant le long de la chaîne logistique (CL). Il fait l'objet d'une attention soutenue par les chercheurs depuis une quinzaine d'années et préoccupe les gestionnaires de CL parce qu'il est une cause importante de perte d'efficacité et d'efficience dans la CL. Le partage d'informations entre acteurs de la CL est généralement considéré comme l'un des principaux moyens de réduction...

  19. Les « étrangers » du roi

    OpenAIRE

    Glesener, Thomas

    2010-01-01

    Cet article s’interroge sur les modifications qui se sont produites entre le xviie et le xviiie siècle quant à la place et au rôle des « nations » dans la Maison militaire des rois d’Espagne. La militarisation des corps de garde rompt avec la fonction représentative des « nations » à la Cour. Le recours aux vassaux européens du roi d’Espagne se fait désormais uniquement dans un but d’efficacité militaire. Toutefois, au sein de l’entourage français du roi d’Espagne, deux conceptions s’affronte...

  20. Enveloppe hybride pour bâtiment économe

    OpenAIRE

    Joussellin, Florence; Faure, Xavier; Johannes, Kévyn; Pierson, Patrick; Quénard, Daniel

    2008-01-01

    National audience; Pour réduire les consommations énergétiques dans les bâtiments, des solutions passives ont été développées en augmentant fortement l'isolation des parois extérieures. Un des moyens d'améliorer l'efficacité énergétique du bâti est de concevoir des façades multifonctionnelles qui permettent de capter les énergies disponibles localement : c'est le principe des enveloppes hybrides, capable à la fois d'isoler, de protéger, mais aussi de capter, stocker, transporter l'énergie. L'...

  1. Etude pour quantifier la part des apports internes dans bâtiment tertiaire BBC. Application au bâtiment de PREDIS

    OpenAIRE

    Chenailler, Hervé; Wurtz, Frédéric; Ploix, Stéphane; Joussellin, Florence; Bontemps, André

    2010-01-01

    National audience; La conception de bâtiments a longtemps été réduite à la conception de leurs enveloppes, reléguant ainsi la représentation des usages à des courbes d'apports internes gratuits. Or, la recherche de meilleures performances en termes d'efficacité énergétique, qui se traduit par le rapport entre les besoins en énergie non gratuite sur le confort pour les occupants, pose le problème de conception en des termes nouveaux. Il s'agit dès lors de vérifier que l'énergie consommée corre...

  2. La maîtrise de l’énergie dans le domaine du bâtiment et des équipements

    OpenAIRE

    2013-01-01

    La question de la maîtrise de la demande d’énergie et de l’efficacité énergétique dans le bâtiment est fondamentale, compte tenu de l’importance des gisements évalués et, surtout, du champ d’action possible. En effet, grâce à la disponibilité immédiate de technologies et de techniques matures, le secteur du bâtiment peut contribuer efficacement à résoudre les défis environnementaux auxquels nous devons faire face. Toutefois, c’est un secteur réputé lent à évoluer à cause de la durée de vie de...

  3. Evaluation du probiotique bactérien Pediococcus acidilactici MA18/5M chez la crevette pénéide Litopenaeus stylirostris en Nouvelle- Calédonie

    OpenAIRE

    Castex, Mathieu

    2009-01-01

    Pediococcus acidilacticii MA18/5M est un probiotique bactérien (BACTOCELL®) qui a démontré son efficacité chez plusieurs espèces d'animaux terrestres et aquatiques. Cette thèse avait pour objectif d'investiguer plus en détails les effets de ce probiotique chez les crevettes pénéides d'élevage. Pour cette étude, nous avons choisi une approche globale replaçant la problématique dans un modèle d'interactions entre trois compartiments : la crevette, sa microflore intestinale et le probiotique. Ap...

  4. Simulation aux grandes échelles du craquage thermique dans l'industrie pétrochimique

    OpenAIRE

    Zhu, Manqi

    2015-01-01

    Pour améliorer l'efficacité des procédés thermiques de craquages et réduire les phénomènes de cokage liés à la température de paroi trop élevée, l'utilisation de tubes nervurés est une technique potentiellement car elle permet d'améliorer le mélange et d'augmenter les transferts de chaleur. Cependant, la perte de charge est significativement augmentée. En raison de la complexité de l'écoulement turbulent, du système chimique et du couplage turbulencechimie, il est difficile d'estimer a priori...

  5. Intelligence stratégique et dissimulation dans les outils de géovisualisation en ligne

    Directory of Open Access Journals (Sweden)

    Samuel Challéat

    2014-06-01

    Full Text Available Les portails de géovisualisation interactive, mis en place sur Internet à la suite de l'emblématique Google Maps, sont plébiscités par le public. Ils donnent à voir d'en haut la surface de notre planète, et plus spécifiquement du territoire français dans le cas du Géoportail. Pourtant, il est interdit de s'approcher trop près de certains objets: sur le territoire national, quelque 150 sites sont dissimulés par l'IGN. Nous questionnons ici la pertinence et l'efficacité de cette opération imposée au principal organisme de production et de diffusion d'informations géographiques en France, en comparaison avec les moyens mis en œuvre par d'autres pays.

  6. Fatigue Assessment in Camp Mirage CC130 Aircrew: Recommendations for Pharmacologic Intervention

    Science.gov (United States)

    2004-02-20

    relève sont affectés par roulement au transport aérien tactique après deux nuits de sommeil inadéquat au CM. La difficulté à dormir est due au...désynchronisme circadien découlant de vols transméridiens d’une telle durée. Au cours de leur deuxième nuit de sommeil au CM (c’est-à-dire de la nuit...précédant leur première mission), les membres de l’équipage nouvellement arrivé ont dormi en moyenne 3,4 heures, ce qui donne une efficacité de sommeil de

  7. Effets du chlorure de cadmium et du chromate de plomb sur deux mollusques bivalves

    OpenAIRE

    Ballan-dufrancais, C.; Jeantet, A.y.; Martoja, R; Truchet, M

    1985-01-01

    La contamination expérimentale d'huîtres par le chlorure de cadmium (500 µg/1 pendant 7 et 26 jours) ne cause aucune lésion histologique ou cytologique, mais elle accélère la déplétion testiculaire et, dans quelques cas, s'oppose au stockage du glycogène. L'excellente résistance des huîtres est due à l'efficacité de deux types de mécanismes de détoxication. Le premier consiste en une immobilisation du cadmium, dans les organes absorbants, dans un état chimique stable et inerte sur le plan mét...

  8. Quality evaluation of two school devices - special education and inclusion in mainstream education - for students of primary education with learning disabilities-difficulties

    OpenAIRE

    Tremblay, Philippe

    2010-01-01

    Cette thèse traite de l’évaluation comparée de la qualité de deux dispositifs scolaires d’intervention auprès d’élèves ayant des troubles d’apprentissage. Pour ce faire, nous avons élaboré et utilisé un modèle multidimensionnel d’évaluation de la qualité composé de neuf dimensions (pertinence, congruité, adéquation, synergie, efficacité, efficience, impact, fiabilité, flexibilité et bien-fondé) s’inspirant du modèle multidimensionnel développé par Bouchard et Plante (2002). Il nous a permis d...

  9. Finlande, Genève : quels modes de prévention et de gestion de l'échec scolaire ? Etude comparative de deux systèmes d'enseignement contrastés

    OpenAIRE

    Ganour, Leila; Niclasse, Marie

    2011-01-01

    L'efficacité et l'équité des systèmes éducatifs sont devenues une préoccupation majeure des chercheurs en Sciences de l'éducation et, dans la foulée, des responsables politiques. En effet, ces indicateurs permettent d'évaluer la capacité des systèmes éducatifs à conduire l’ensemble des élèves vers la maîtrise d'un socle minimal de compétences, tout en réduisant les inégalités scolaires. Or, tous les systèmes ne sont pas aussi efficaces et équitables. Afin d'approfondir cette question, au coeu...

  10. Images du Valais

    Directory of Open Access Journals (Sweden)

    Micheline COSINSCHI

    1995-06-01

    Full Text Available Une étude des revenus fiscaux ventilés par branches économiques permet de clore un ouvrage portant sur ce canton alpin suisse par excellence qu’est le Valais. Pris comme traceurs de l’activité régionale, l’analyse de leurs configurations spatiales permet une évaluation pouvant être considérée comme une mesure de l’efficacité différentielle du système socio-spatial valaisan. L’article décrit certains processus qui ont permis la réalisation du dernier chapitre d’un atlas portant sur le Valais.

  11. Nécrose pancréatique infectieuse des salmonidés : évaluation de méthodes destinées à couper la transmission par l'oeuf

    Directory of Open Access Journals (Sweden)

    DORSON M.

    1996-01-01

    Full Text Available Des ovules de truites Arc-en-Ciel ont été fécondés par des spermatozoïdes de la même espèce traités par l'iode suivant différents protocoles afin de couper la transmission de la nécrose pancréatique infectieuse (NPI des salmonidés. L'efficacité de l'iode a été évaluée en parallèle par neutralisation du virus en 1 mn. Le protocole conseillé pour la solution d'iode disponible dans le commerce (ovules égouttés, puis recouverts de solution- iodée et sperme ajouté immédiatement a d'abord été utilisé. A pH compris entre 5 et 8 et pour des concentrations en iode de 15, 25 et 35 mg/l, le pourcentage de fécondation est inférieur à 10 et ne remonte qu'à pH 9 (69 % pour 25 mg/l. Par contre, l'efficacité contre le virus décroît rapidement pour des pH supérieurs à 7, et aucun pH n'a permis de concilier efficacité et innocuité. Le même protocole'utilisé avec 10 spermes individuels a montré des différences de sensibilité individuelle marquées (pourcentages de fécondation de 1,6 à 37 % pour 25 mg/l d'iode à pH8, qui ne sont pas en corrélation avec la qualité des spermes appréciée par la concentration de la protéine de membrane 42 kDa dans le liquide séminal. Les différents essais de préincubation du sperme (de quelques secondes à 1 minute ont donné des rendements de fécondation nuls, sauf pour un large excès de sperme, qui entraînait aussi la perte de l'efficacité de l'iode contre le virus. Deux expériences de transmission expérimentale ont été réalisées en incubant les spermatozoïdes avec du virus concentré. L'élimination systématique des oeufs morts et anormaux suivie d'une désinfection externe des oeufs (50 mg/l d'iode, 15 mn avant l'éclosion n'a pas permis dé couper la transmission, ce qui laisse supposer que le virus peut être transmis sans infecter l'embryon de façon létale.

  12. Mesure de la qualité des services d’enseignement et restructuration des secteurs éducatifs

    OpenAIRE

    Vinokur, Annie

    2012-01-01

    L’article de Romuald Normand a décrit la genèse, aux États-Unis, du mouvement de mobilisation des technologies de mesure de la qualité pour rationaliser la pédagogie scolaire sur le modèle industriel. Ce modèle tend maintenant à s’étendre à l’évaluation de la qualité des producteurs de services d’enseignement et à se déployer à l’échelle mondiale dans le but d’accroître l’efficacité des secteurs éducatifs et de réguler leur transnationalisation. On tente ici d’en montrer la fonctionnalité – m...

  13. Mesurer la performance des chercheurs, au risque de la bureaucratie

    OpenAIRE

    Berland, Nicolas; Dreveton, Benjamin

    2012-01-01

    Nous sommes entrés dans l'ère des sociétés de la connaissance qui nous amène à considérer les activités de recherche avec une acuité nouvelle. Exercée jusqu'alors en marge de la société productive, la recherche s'est vue demandée des comptes sur son efficacité et son utilité. Les chercheurs sont devenus " accountable " (Osterloh et al., 2008). Des pratiques de contrôle qui existaient déjà se sont durcies, professionnalisées et institutionnalisées. Dans le cadre de cet article, nous chercheron...

  14. C. Marcigny, E. Ghesquière, dir., L'île de Tatihou (Manche à l'âge du Bronze. Habitats et occupation du sol, DAF n° 96

    Directory of Open Access Journals (Sweden)

    Pierre-Yves Milcent

    2006-05-01

    Full Text Available L'ouvrage consacré à l'îlot de Tatihou illustre l'efficacité de la politique d'archéologie préventive initiée en Basse-Normandie ces dernières années. Il n'est pas inutile de se souvenir que la Protohistoire dans cette région faisait figure de parent pauvre par le passé, au point qu'il était extrêmement difficile d'articuler les données archéologiques armoricaines à celles que l'on connaissait pour le centre et le nord du Bassin parisien. En limite du Massif armoricain et près de la pointe no...

  15. Bivalves: Indicateurs de pollution microbienne des eaux littorales

    OpenAIRE

    Plusquellec, A; Beucher, M; Legal, Y

    1984-01-01

    Une étude a été réalisée en baie de Concarneau (France), dans le but de comparer la contamination de l'eau et de moules d'un même site naturel par le dénombrement des indicateurs fécaux usuels : Coliformes fécaux et Streptocoques fécaux. La concentration par les bivalves est importante, mais diffère pour les deux indicateurs bactériens. Le dénombrement des Streptocoques fécaux dans les bivalves permet d'annuler une partie des variations observées dans l'eau. L'efficacité des moules comme maté...

  16. Partenariats public-privé et investissements de fin de contrat : le cas de l'industrie de l'eau en France

    OpenAIRE

    2010-01-01

    L’efficacité des partenariats public-privé (PPP) dans les industries de service public en réseau a été remise en cause par de nombreux auteurs. Une des défaillances majeure reprochée à ce type d’accords concerne le manque d’incitation de l’opérateur en place à investir en fin de contrat. Le but de cet article est double. Tout d’abord, nous expliquons pourquoi l’industrie française de l’eau se caractérise par une logique de sous investissement en fin de contrat. Ensuite en utilisant une base d...

  17. Modes d'Organisation et Distribution de l'eau: Une Evaluation empirique de la Performance par les Méthodes des frontières de production

    OpenAIRE

    2014-01-01

    Cette thèse est une contribution à l’analyse empirique de la performance (efficacité technique et effectivité) dans le secteur de la distribution de l’eau en Afrique Subsaharienne. Nous cherchons à répondre à la question de l’impact des modes d’organisation (participation du secteur privé, régulation et une combinaison de deux) sur l’amélioration de la performance dans ce secteur. Notre analyse s’appuie sur les données issues de la base des données de l’AICD pour la période 2000 à 2005. P...

  18. Les kystes hydatiques du foie rompus dans les voies biliaires: a propos de 120 cas

    Directory of Open Access Journals (Sweden)

    Mountassir Moujahid

    2011-11-01

    Full Text Available s et une anastomose bilio digestive choledoco duodenale dans 10 cas. La duree moyenne d�hospitalisation etait de 20jours. Nous deplorons deux deces par choc septique et un troisieme par encephalopathie secondaire a une cirrhose biliaire. La morbidite etait representee par huit abces sous phrenique, douze fistules biliaires prolongees et deux occlusions intestinales. Les kystes hydatiques rompus dans les voies biliaires representent la complication la plus grave de cette pathologie benigne. Le traitement repose sur des methodes radicales qui sont d�une efficacite reconnue, mais de realisation dangereuse et les methodes conservatrices, en particulier la deconnexion kysto biliaire qui est une methode simple et qui donne de bons resultas a court et a long terme.

  19. La construcción de eficiencias colectivas en redes de PyMES

    OpenAIRE

    Obeso, María de Jesús

    2014-01-01

    Cet article présente les résultats d’un réseau de petits et moyens producteurs de l’aquaculture au Mexique qui, après avoir travaillé ensemble, ont atteint l’efficacité collective. La stratégie méthodologique utilisée est l’étude de cas. Des aspects conceptuels et théoriques des réseaux et l’action collective ont été considérés pour expliquer le processus d’interaction entre les acteurs et ce qui a été la base de leurs interdépendances. Le modèle de coopération que nous étudions privilégie le...

  20. Traitement de l’ambiguïté dans les logiciels de traduction automatique en ligne

    Directory of Open Access Journals (Sweden)

    Jean Ntakirutimana

    2010-05-01

    Full Text Available Il existe de nos jours plusieurs logiciels de traduction automatique et bon nombre d’entre eux sont accessibles sur l’internet. Ainsi, des moteurs de recherche comme AltaVista ou Yahoo proposent aux internautes d’afficher les pages Web cibles en versions traduites instantanément dans la langue de choix de l’utilisateur. À l’instar d’autres gadgets issus des nouvelles technologies de l’information et de la communication (NTIC, les logiciels de traduction automatique sont largement utilisés partout dans le monde, et certains utilisateurs ne s’interrogent même pas sur l’efficacité réelle de ces nouveaux outils langagiers. L’on comprend alors pourquoi la traduction automatique génère ci et là, et de façon quasi anodine, des perles langagières du genre.