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Sample records for aplasia efficacite therapeutique

  1. Radiological Findings of Michel Aplasia

    Science.gov (United States)

    Umul, Ayse; Demirtas, Hakan; Celik, Ahmet Orhan

    2016-01-01

    Introduction: Congenital abnormalities of the inner ear is the most common cause of neurosensory hearing loss. Michel inner ear deformity is a rare developmental anomaly refers to the total aplasia of the inner ear. It is caused by developmental arrest of otic placode early during the third week of gestational age. Case report: We have discussed here that three year old girl diagnosed Michel aplasia with temporal bone computed tomography (CT) and temporal magnetic resonance imaging (MRI) findings. PMID:27482139

  2. Aplasia of major pectoral muscle combined with renal aplasia and cystic malformation of common iliac vein

    DEFF Research Database (Denmark)

    Qvist, N; Nielsen, K; Christensen, P V

    1987-01-01

    We report a case of an eighteen-year-old male with combined aplasia of the major pectoral muscle, renal aplasia, and malformation of the common iliac vein. The possibility of a common genesis is discussed on the basis of embryology....

  3. Ectrodactyly with fibular aplasia : A separate entity?

    NARCIS (Netherlands)

    Menke, Leonie A.; Bijlsma, Emilia K.; van Essen, Anthonie J.; van den Boogaard, Marie-Jose H.; van Rijn, Rick R.; Cobben, Jan Maarten

    2008-01-01

    E/FA is the combination of ectrodactyly (split hand/foot malformation, SHFM) and fibular aplasia. It is a rare disorder considered to be inherited in an autosomal dominant fashion with reduced penetrance and variable expression. In order to determine recurrence risks for the two patients we describe

  4. Unilateral optic nerve aplasia associated with microphthalmos

    Directory of Open Access Journals (Sweden)

    Stanković-Babić Gordana

    2012-01-01

    Full Text Available Intraduction. Optic nerve aplasia is a rare developmental anomaly characterised by the congenital absence of the optic nerve, central retinal vessels and retinal ganglion cells that is seen most often in a unilaterally malformed eye. Case report. We reported a girl with a very rare anomaly of the eye, unilateral aplasia of the optic nerve and microphthalmia. We carried out a complete ophthalmological examination, A- and Bscan ultrasonography, magnetic resonance imaging (MRI of the orbit and brain, pediatrician, neurological examinations and karyotype determination. The examined child was a third child from the third regular pregnancy, born at term (39 GS, BM 3100 g. Family ocular history was negative. The right corneal diameter was 7.5 mm and left 10 mm. On dilated fundus examination, the right eye showed the absence of optic nerve and central retinal vessels. B-scan echography showed a small right globe (axial length 13.80 mm, normal size left globe (axial length 18.30 mm and the absence of optic nerve on the right eye. Physical and neurological findings and karyotype was normal. MRI of the orbits and brain marked asymmetry of globe size and unilateral absence of the optic nerve. The patient is under the control of a competent ophthalmologist and prosthetic. Conclusion. Further aesthetic and functional development of a young person is the primary goal in tracking this rare congenital optic nerve anomalies in the malformed eye.

  5. Pulmonary Aplasia in an Adult : A Case Report

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    Nurettin Yiyit

    2016-01-01

    Full Text Available Pulmonary aplasia is a rare congenital anomaly in which there are absence of pulmonary vessels, bronchus and parenchyma. It is distinguished from pulmonary agenesis by the presence of rudimentary stump bronchus. Patients are usually diagnosed in childhood. Patients without additional anomaly and the patients with mild disease can be diagnosed in adulthood. The left lung was not observed at the chest X-ray of 19-year-old male patient with respiratory distress in exercise. Left lung aplasia was diagnosed by computed tomography and ventilation perfusion scintigraphy. The patients with lung aplasia have an increased risk of infections. Therefore the follow-up of the patients is important.

  6. A. Bandura. Auto-efficacité. Le sentiment d’efficacité personnelle

    OpenAIRE

    Rondier, Maïlys

    2009-01-01

    Albert Bandura est docteur en psychologie et enseigne à l’université de Stanford (Californie). Il est l’auteur de L’Apprentissage social (Mardaga, 1985). Depuis les années 80, Albert Bandura s’intéresse au sentiment d’efficacité personnelle. Ce concept s’inscrit dans le cadre de la théorie sociocognitive (théorie issue du béhaviorisme et du cognitivisme). Selon cette théorie, le fonctionnement et le développement psychologique doivent être compris en considérant trois facteurs en interaction ...

  7. Genetics Home Reference: Müllerian aplasia and hyperandrogenism

    Science.gov (United States)

    Skip to main content Your Guide to Understanding Genetic Conditions Enable Javascript for addthis links to activate. ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions Müllerian aplasia and hyperandrogenism Müllerian ...

  8. Laparoscopic Morcellation of Didelphic Uterus With Cervical and Renal Aplasia

    OpenAIRE

    Altchek, Albert; Brodman, Michael; Schlosshauer, Peter; Deligdisch, Liane

    2009-01-01

    This is a case report (and review of the literature) of a 12-year and 10-month-old girl with a rare congenital anomaly of uterus didelphys, unilateral cervix aplasia, and ipsilateral renal aplasia. She had severe dysmenorrhea from the first menses. In an effort to preserve fertility, a cervical fistula was made that closed over. A laparoscopic hemi-hysterectomy was done successfully and rapidly with laparoscopic morcellation. Because no ureter was present, it was not necessary to trace it. Fo...

  9. Acquired pure megakaryocytic aplasia successfully treated with cyclosporine

    Directory of Open Access Journals (Sweden)

    Halima El Omri

    2010-12-01

    Full Text Available Acquired pure megakaryocytic aplasia is a rare hematological disorder characterized by thrombocytopenia with absent or markedly reduced megakaryocytes in the bone marrow. We report a case of a 25-year-old male diagnosed as acquired pure megakaryocytic aplasia. Treatment with prednisone and intravenous immunoglobulin failed, but he was successfully treated with cyclosporine, with complete remission after 90 days and normal platelet count maintained thereafter.

  10. From labyrinthine aplasia to otocyst deformity

    Energy Technology Data Exchange (ETDEWEB)

    Giesemann, Anja Maria; Goetz, Friedrich; Lanfermann, Heinrich [Hannover Medical School, Department of Diagnostic and Interventional Neuroradiology, Hannover (Germany); Neuburger, Juergen; Lenarz, Thomas [Hannover Medical School, Department of Otorhinolaryngology, Hannover (Germany)

    2010-02-15

    Inner ear malformations (IEMs) are rare and it is unusual to encounter the rarest of them, namely labyrinthine aplasia (LA) and otocyst deformity. They do, however, provide useful pointers as to the early embryonic development of the ear. LA is characterised as a complete absence of inner ear structures. While some common findings do emerge, a clear definition of the otocyst deformity does not exist. It is often confused with the common cavity first described by Edward Cock. Our purpose was to radiologically characterise LA and otocyst deformity. Retrospective analysis of CT and MRI data from four patients with LA or otocyst deformity. Middle and inner ear findings were categorised by two neuroradiologists. The bony carotid canal was found to be absent in all patients. Posterior located cystic structures were found in association with LA and otocyst deformity. In the most severe cases, only soft tissue was present at the medial border of the middle ear cavity. The individuals with otocyst deformity also had hypoplasia of the petrous apex bone. These cases demonstrate gradual changes in the two most severe IEMs. Clarification of terms was necessary and, based on these findings, we propose defining otocyst deformity as a cystic structure in place of the inner ear, with the cochlea, IAC and carotid canal absent. This condition needs to be differentiated from the common cavity described by Edward Cook. A clear definition of inner ear malformations is essential if outcomes following cochlear implantation are to be compared. (orig.)

  11. Acquired pure red cell aplasia in a child.

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    Sharma R

    2002-01-01

    Full Text Available Primary acquired pure red cell aplasia is a rare occurrence in childhood. An eleven-year old boy presented to us with pallor, which required multiple packed red cell transfusions. He did not have hepatosplenomegaly, jaundice or lymphadenopathy. Bone marrow examination revealed the diagnosis of pure red cell aplasia. All possible investigations were done to exclude secondary causes of pure red cell aplasia. No secondary cause was found on investigations. Rheumatoid factor and anti-nuclear antibodies were positive. He was started on oral steroids, to which he did not respond. He was then given cyclosporine A. Response to cyclosporine was dramatic and the child now does not require any transfusions.

  12. Aplasia and hypoplasia of the maxillary sinus: A case series

    Directory of Open Access Journals (Sweden)

    Nasim Jafari-Pozve

    2014-01-01

    Full Text Available Maxillary sinus aplasia and hypoplasia are rare conditions that can cause symptoms such as headaches and voice alteration. The majority of patients are asymptomatic, but these conditions must be noticed for importance of differential diagnosis such as infection and neoplasms. Conventional radiographs could not differentiate between inflammatory mucosal thickening, neoplasm, and hypoplasia of the sinus. Computed tomography (CT and also cone beam computed tomography (CBCT are the proper modalities to detect these conditions. In the present study, CBCT findings of three cases with maxillary sinus hypoplasia and aplasia are reported.

  13. Radial aplasia and chromosome 22q11 deletion.

    Science.gov (United States)

    Digilio, M C; Giannotti, A; Marino, B; Guadagni, A M; Orzalesi, M; Dallapiccola, B

    1997-01-01

    We report on a neonate with deletion 22q11 (del22q11) presenting with facial dysmorphism, ocular coloboma, congenital heart defect, urogenital malformations, and unilateral radial aplasia. This malformation complex includes features frequently occurring in velocardiofacial syndrome as well as findings described in the CHARGE and VACTERL associations. To our knowledge, the present case is the first report of radial aplasia in del22q11. This observation further supports and extends the clinical variability of del22q11. Images PMID:9391893

  14. Primary cutaneous aspergillosis and idiopathic bone marrow aplasia*

    Science.gov (United States)

    Furlan, Karina Colossi; Pires, Mario Cezar; Kakizaki, Priscila; Chartuni, Juliana Cabral Nunes; Valente, Neusa Yuriko Sakai

    2016-01-01

    We describe the case of a 9-year-old boy with idiopathic bone marrow aplasia and severe neutropenia, who developed skin ulcers under cardiac monitoring electrodes. The diagnosis of primary cutaneous aspergillosis was made after the second biopsy and culture. Imaging investigation did not reveal internal fungal infection. The child was treated, but did not improve and died 3 months after admission. The report highlights and discusses the preventable risk of aspergillus skin infection in immunocompromised patients. PMID:27438213

  15. The association of aplasia cutis congenita with therapy of maternal thyroid disease.

    Science.gov (United States)

    Kalb, R E; Grossman, M E

    1986-09-01

    Aplasia cutis congenita, the localized absence of skin at birth, usually is an isolated scalp defect. We examined an infant with aplasia cutis congenita associated with maternal Grave's disease and the use of methimazole during pregnancy. This association was reported twice before. It has certain implications with respect to therapy of pregnant hyperthyroid women. PMID:3774652

  16. Electroconvulsive Therapy and Corpus Callosum Aplasia: A 3-Year Followup

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    Ulrich Palm

    2011-01-01

    Full Text Available Electroconvulsive Therapy (ECT is a powerful treatment option in severe or chronic catatonic states and has been reported to be useful in oligophrenic patients. We report the followup medical history of a patient with corpus callosum aplasia (or agenesis who was continuously treated with ECT over three years. First, he improved considerably after a series of ECT, but relapses of catatonia made a continuous, weekly ECT necessary. Due to the severity of the brain malformation, an add-on medication with benzodiazepines and second generation antipsychotics was necessary to treat catatonic symptoms. This case emphasises the benefits of long-term ECT in oligophrenic patients.

  17. THE PURE RED BLOOD CELL APLASIA IN RENAL TRANSPLANT RECIPIENT

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    B. T. Dzumabaeva

    2011-01-01

    Full Text Available The pure red blood cell aplasia of renal transplant recipients caused by parvovirus B19 (PB19 is characterized by persistent anemia which resistant to erythropoietin therapy, lack of reticulocytes, bone marrow hypoplasia, and clinically accompanied by severe recurrent bacterial, fungal and viral infection. In case of reactivation PB19 it is necessarv, first of all, eliminate the causes activation of this virus and to cancel or reduce the dose of drugs which depressed the normal hematopoiesis germs, thus to reduce the pancytopenia associating complications in this population. 

  18. Pure red cell aplasia induced by epoetin zeta.

    Science.gov (United States)

    Panichi, Vincenzo; Ricchiuti, Guido; Scatena, Alessia; Del Vecchio, Lucia; Locatelli, Francesco

    2016-08-01

    Pure red cell aplasia (PRCA) may develop in patients with chronic kidney disease receiving erythropoiesis-stimulating agents (ESA). We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-titre neutralizing anti-erythropoietin antibodies (Ab), a diagnosis of Ab-mediated PRCA was made. Epoetin zeta was discontinued and the patient was given steroids. This was associated with anaemia recovery. To our knowledge this is the first PRCA case related to epoetin zeta. PMID:27478604

  19. Pure red cell aplasia following autoimmune hemolytic anemia: An enigma

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    M Saha

    2013-01-01

    Full Text Available A 26-year-old previously healthy female presented with a 6-month history of anemia. The laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. With a diagnosis of autoimmune hemolytic anemia (AIHA, prednisolone was started but was ineffective after 1 month of therapy. A bone marrow trephine biopsy revealed pure red cell aplasia (PRCA showing severe erythroid hypoplasia. The case was considered PRCA following AIHA. This combination without clear underlying disease is rare. Human parvovirus B19 infection was not detected in the marrow aspirate during reticulocytopenia. The patient received azathioprine, and PRCA improved but significant hemolysis was once again documented with a high reticulocyte count. The short time interval between AIHA and PRCA phase suggested an increased possibility of the evolution of a single disease.

  20. Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast

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    Francesca Labbadia

    2012-09-01

    Full Text Available A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

  1. Uterine horn aplasia with complications in two mixed-breed bitches : case report

    OpenAIRE

    M.L. Schulman; L.A. Bolton

    1997-01-01

    Unilateral segmental uterine horn aplasia was found in 2 mixed-breed bitches. The 1st bitch was presented with clinical signs of acute abdominal pain, and pyometra was suspected. Pyometra was confirmed surgically with rupture of a blind-ending cranial portion of the anomalous right uterine horn, which had resulted in peritonitis. The 2nd bitch was presented for routine ovariohysterectomy. The right uterine horn was affected by segmental aplasia, with mucometra of the cranial portion of the af...

  2. Conférence sur l'efficacité

    CERN Document Server

    Jullien, François

    2005-01-01

    Philosophe et sinologue, François Jullien présente ici une conférence qu'il a prononcée auprès de chefs d'entreprise et dans le milieu du management. D'un côté, la conception européenne de l'efficacité est liée à la modélisation comme à la finalité et revendique l'action jusqu'à l'héroïsme ; de l'autre, la pensée chinoise de l'efficience, indirecte et discrète, s'appuie sur le potentiel de situation et induit des " transformations silencieuses ", sans éclat ni même événement. Par-delà cet écart, il s'agira d'interroger la nature de l'effectivité ; ou comment l'intervention humaine réussit à se brancher sur la propension des choses et s'y laisse intégrer. Ce propos se garde donc de séparer tant soit peu l'art d'opérer sur des situations et l'exercice de la philosophie ; en résultent des effets de lecture portant sur l'histoire du XXe siècle ainsi que la géopolitique - et géoéthique - à venir.

  3. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

    OpenAIRE

    E. Bulliorsky; C. Shanley; G. Stemmelin; J. Ceresetto; O. Rabinovich

    2002-01-01

    El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH) con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoy...

  4. Aggressive large cell lymphoma: early assessment of therapeutic efficacy by positron emission tomography; Lymphome agressif a grandes cellules: appreciation precoce de l'efficacite therapeutique par la TEP au [{sup 18}F]-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Itti, E.; Maignan, M. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Medecine Nucleaire, 94 - Creteil (France); Haioun, C.; Reyes, F. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service d' Hematologie Clinique, 94 - Creteil (France); Rahmouni, A. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Radiologie, 94 - Creteil (France)

    2004-07-01

    The international prognostic index is a well-established tool for stratifying patients with aggressive non-Hodgkin's lymphoma scheduled for tailored therapy. Early FDG-PET imaging could play a major predictive role for patient survival by providing functional information about lymphoma chemo-sensitivity. We present here the results of the interim analysis (about SD patients) of a prospective multi-centre study (national PHRC), the goals of which were to correlate PET response after 2 induction cycles 1) to the therapeutic response assessed by conventional diagnostic methods and 2) to event free survival and global survival. (author)

  5. Marrow fat cell: response to x-ray induced aplasia

    International Nuclear Information System (INIS)

    Adipose tissue is an integral structural component of normal rabbit marrow and is believed to behave primarily as a cushion in response to hemopoietic proliferation, accommodating to changes in hemopoiesis by change in either size or number or both of the fat cells in order to maintain constancy of the marrow volume. To test this hypothesis, aplasia of the right femur of New Zealand white rabbits was induced by x irradiation with 8000 rads; the left unirradiated limb served as control. Twenty-four hours before sacrifice 50 μCi of palmitate-114C was administered intravenously and the marrow of both femurs removed. Samples of perinephric fat were taken for comparison. Fat cell volume, C14 palmitate turnover and fatty acid composition were determined. The total number of fat cells in the entire marrow of both femurs was calculated. The measurements showed no difference in size or fatty acid turnover of the fat cells in the irradiated aplastic marrow from the cells of the control marrow. The number of fat cells in both the irradiated and the unirradiated control femurs was essentially the same. These findings do not support the view that marrow fat cells respond to diminished hematopoiesis by either increase in their volume or number. In addition, the findings suggest that both marrow and subcutaneous fat cells are fairly resistant to high doses of x-ray irradiation

  6. Medullary aplasia secondary to an irradiation accident: Treatment options and evolution of the concepts; L'aplasie medullaire secondaire a un accident d'irradiation : options therapeutiques et evolution des concepts

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, T. [Service d' Hematologie, HIA Percy, et Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Fagot, T.; Souleau, B. [Service d' Hematologie, HIA Percy, Clamart (France); Dormont, D. [Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Nedellec, G. [Service d' Hematologie, HIA Percy, Clamart (France)

    2002-07-01

    Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods. (author)

  7. A Patient with Unilateral Tibial Aplasia and Accessory Scrotum: A Pure Coincidence or Nonfortuitous Association?

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    Zoran Gucev

    2010-01-01

    Full Text Available Tibial aplasia is an uncommon lower limb malformation that can occur isolated or be part of a more complex malformation pattern. We describe a 9-year-old boy born after uneventful pregnancy and delivery. Family history was negative for maternal diabetes and other malformations. The patient presented with left tibial aplasia and homolateral prexial foot polydactyly. He also displayed enamel dysplasia and bifid scotum with cryptorchidism. Literature review failed to identify a significant syndromic association between lower limb defects of the tibial type and the genital anomalies reported here. The combination of tibial aplasia with midline genital malformations further supports the hypothesis that the tibial ray development mirrors the morphogenetic process of the radial structures. Accordingly, the malformation pattern observed in the present patient may be pathogenetically explained by an insult occurring during late blastogenesis.

  8. Uterine horn aplasia with complications in two mixed-breed bitches : case report

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    M.L. Schulman

    1997-07-01

    Full Text Available Unilateral segmental uterine horn aplasia was found in 2 mixed-breed bitches. The 1st bitch was presented with clinical signs of acute abdominal pain, and pyometra was suspected. Pyometra was confirmed surgically with rupture of a blind-ending cranial portion of the anomalous right uterine horn, which had resulted in peritonitis. The 2nd bitch was presented for routine ovariohysterectomy. The right uterine horn was affected by segmental aplasia, with mucometra of the cranial portion of the affected horn. Histopathology demonstrated both uteri to have diffuse cystic endometrial hyperplasia. It is postulated that cystic endometrial hyperplasia, together with the congenital anomaly, resulted in pyometra in one case and in mucometra in the other case. This is believed to be the 1st report of uterine horn aplasia in the bitch in association with clinical signs and lesions other than infertility.

  9. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.ABO incompatibility in allogeneic bone marrow transplantation may be associated with incomplete or delayed erythroid engraftment, being pure red cell aplasia (PRCA the most severe complication in this setting. Attempts for the treatment of PRCA have been made with erythropoietin or with plasmapheresis with relative success, and some authors have reported the reversibility of PRCA with antilymphocyte globulin (ALG or ATG, based on the assumption that PRCA might be immunologically mediated. We report herewith a patient with acute leukemia who developed post - BMT pure red cell aplasia. His sibling donor (sister was HLA identical and ABO incompatible, having low agglutinin

  10. Congenital aplasia of the optic chiasm and esophageal atresia: a case report

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    Madonia Maurizio

    2011-08-01

    Full Text Available Abstract Introduction The complete absence of the chiasm (chiasmal aplasia is a rare clinical condition. Hypoplasia of the optic nerve and congenital nystagmus are almost invariably associated characteristics. Microphthalmos or anophthalmos are common features in chiasmal aplasia, while central nervous system abnormalities are less frequent. Esophageal atresia can be isolated or syndromic. In syndromic cases, it is frequently associated with cardiac, limb, renal or vertebral malformations and anal atresia. More rarely, esophageal atresia can be part of anophthalmia-esophageal-genital syndrome, which comprises anophthalmia or microphthalmia, genital abnormalities, vertebral defects and cerebral malformations. Here, a previously unreported case of chiasmal aplasia presenting without microphthalmos and associated with esophageal atresia is described. Case presentation Aplasia of the optic chiasm was identified in a Caucasian Italian 8-month-old boy with esophageal atresia. An ultrasound examination carried out at 21 weeks' gestation revealed polyhydramnios. Intrauterine growth retardation, esophageal atresia and a small atrial-septal defect were subsequently detected at 28 weeks' gestation. Repair of the esophageal atresia was carried out shortly after birth. A jejunostomy was carried out at four months to facilitate enteral feeding. The child was subsequently noted to be visually inattentive and to be neurodevelopmentally delayed. Magnetic resonance imaging revealed chiasmal aplasia. No other midline brain defects were found. His karyotype was normal. Conclusion If achiasmia is a spectrum, our patient seems to depict the most severe form, since he appears to have an extremely severe visual impairment. This is in contrast to most of the cases described in the literature, where patients maintain good--or at least useful-- visual function. To the best of our knowledge, the association of optic nerve hypoplasia, complete chiasmal aplasia, esophageal

  11. RETREATMENT WITH FLUDARABINE AND CYCLOSPORINE FOR ONE CASE OF REFRACTORY PURE RED CELL APLASIA

    Institute of Scientific and Technical Information of China (English)

    Guang-sheng He; Xiang Zhang; De-pei Wu; Ai-ning Sun; Miao Miao; Xiu-li Wang; Zheng-ming Jin

    2008-01-01

    @@ MANY cases of pure red cell aplasia (PRCA) were mediated by over-function of immune cells, and responded well to immunosuppres-sive therapy.1 Sometimes refractory cases also arose. Fludara-bine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia (CLL) and other hematological malignancies.

  12. Reconstruction of bilateral tibial aplasia and split hand-foot syndrome in a father and daughter

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    Ali Al Kaissi

    2014-01-01

    Full Text Available Background: Tibial aplasia is of heterogeneous aetiology, the majority of reports are sporadic. We describe the reconstruction procedures in two subjects - a daughter and father manifested autosomal dominant (AD inheritance of the bilateral tibial aplasia and split hand-foot syndrome. Materials and Methods: Reconstruction of these patients required multiple surgical procedures and orthoprosthesis was mandatory. The main goal of treatment was to achieve walking. Stabilization of the ankle joint by fibular-talar-chondrodesis on both sides, followed by bilateral Brown-procedure at the knee joint level has been applied accordingly. Results: The outcome was with improved function of the deformed limbs and walking was achieved with simultaneous designation of orthotic fitting. Conclusion: This is the first study encompassing the diagnosis and management of a father and daughter with bilateral tibial aplasia associated with variable split hand/foot deformity without foot ablation. Our patients showed the typical AD pattern of inheritance of split-hand/foot and tibial aplasia.

  13. APLASIA CUTIS CONGENITAL WITH AMNIOTIC BAND DISRUPTION COMPLEX: A RARE CASE REPORT

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    Pradipprava

    2015-09-01

    Full Text Available Aplasia cutis congenita (ACC is congenital absence of skin, most commonly affecting scalp. Etiology is multifactorial like intrauterine infection, teratogens, vascular causes, genetic syndromes etc. We here represent an infant with ACC involving extremities and associated with amniotic band disruption complex. He was treated conservatively and discharged.

  14. Segmental aplasia of the uterine horn with ipsilateral renal agenesis in a cat.

    Science.gov (United States)

    Chang, Jinhwa; Jung, Joo-hyun; Yoon, Junghee; Choi, Min-cheol; Park, Jae Hak; Seo, Kang-Moon; Jeong, Seong Mok

    2008-06-01

    A nine-month-old domestic short haired cat was admitted with the history of acute vomiting, depression and shivering. Abdominal ultrasonography revealed minimum enlargement of the right uterine horn filled with anechoic fluid. On excretory urography, functionally and anatomically normal, enlarged left kidney was found, but right kidney was absent. It was preliminary diagnosed as hydrometra with right renal agenesis. Aiming at the correction of hydrometra, we performed ovariohysterectomy. During spaying, we found a missing segment of distal part of the right uterine horn and absence of ipsilateral kidney and ureter. Compressed uterine structure and segmental aplasia of right uterine horn were found in histopathological investigation. Taken together, it was diagnosed as a segmental aplasia of uterine horn with ipsilateral renal agenesis. PMID:18628611

  15. Pulmonary Sequestration with Renal Aplasia and Elevated SUV Level in PET/CT

    Directory of Open Access Journals (Sweden)

    Serdar Şen

    2012-01-01

    Full Text Available Extralobar sequestration with other bronchopulmonary malformations is commonly seen; however, the association of extralobar sequestration with renal aplasia is very rare. A 75-year-old female patient was admitted with back pain. Ultrasonography revealed aplasia of the left kidney and tomography showed 6×4.5 cm sized tumor in the left hemithorax at the posterobasal area. The lesion has focally increased glycolytic activity (SUVmax: 3.2 at the left upper pole on positron emission tomography scan (PET/CT. Sequestrectomy was performed after the confirmation by frozen section that the lesion was benign and of extrapulmonary sequestration. No complication occurred during postoperative and 50-month follow-up period.

  16. [Acute hepatitis-associated pure red cell aplasia: a case report].

    Science.gov (United States)

    Della Loggia, Paolo; Cremonini, Laura

    2002-12-01

    After a holiday in Egypt, a 57-year-old caucasian woman developed acute hepatitis A. The illness seemed initially to have a benign course, with a decreasing trend of hepatic enzymes and an apparent recovery. Three weeks later a relapse occurred. Recurrence of symptoms and aminotransferase elevation were associated with severe anemia; a hyporegenerative anemia was diagnosed and all laboratory findings were consistent with pure red cell aplasia. The haematologic disorder was successfully treated with red cell transfusion and glucocorticoids.

  17. Anti-Erythropoietin Antibody Associated Pure Red Cell Aplasia Resolved after Liver Transplantation

    OpenAIRE

    Hung, Annie K.; Jennifer Guy; Behler, Caroline M.; Lee, Eugene E.

    2015-01-01

    Patients undergoing antiviral therapy for chronic hepatitis C often develop anemia secondary to ribavirin and interferon. Recombinant erythropoietin has been used to improve anemia associated with antiviral therapy and to minimize dose reductions, which are associated with decreased rates of sustained virologic response. A rare potential side effect of recombinant erythropoietin is anti-erythropoietin antibody associated pure red cell aplasia. In chronic kidney disease patients with this enti...

  18. [Risk factors for teeth aplasia and hypoplasia in cleft lip and palate children].

    Science.gov (United States)

    Korolenkova, M V; Starikova, N V; Ageeva, L V

    2016-01-01

    The aim of the study was to assess the significance of environmental risk factors for teeth aplasia and hypoplasia in cleft lip and palate children. Two hundred and forty-seven cleft lip and palate (CLP) children were enrolled in the study including 105 (42.5%) with bilateral CLP and 57.5% with unilateral CLP. The mean age was 11.2±4.9 years. Teeth condition was assessed clinically and radiologically. The impact of risk factors for teeth anomalies was analyzed by retrospective data obtained from computer database (absence of preoperative orthopedic treatment, palatal defects after primary palatoplasty and type of primary procedures). Surgical trauma by early periosteoplasty (at the age of 3-4 months), excessive scarring and tissue traction due to absence of early orthopedic treatment and palatal defect were associated with significantly higher incidence of incisors hypoplasia (both developmental enamel defects and microdentia) and aplasia of central incisors not seen in the other study subgroups. Incisors aplasia and hypoplasia in CLP patients do not always have disembryogenic origin but may depend on external environmental factors, including surgical trauma.

  19. Les secrets de l'efficacité en faire plus... en moins de temps

    CERN Document Server

    Savoyat, Bruno

    2006-01-01

    Comment gagner en efficacité grâce à une meilleure organisation et à une utilisation plus performante de l'informatique. Ce livre, rédigé par un spécialiste internationalement reconnu des méthodes d'optimisation du travail, vous fournit £ une méthode de hiérarchisation des tâches et 0 les règles qui vous permettront d'acquérir une meilleure organisation personnelle et collective. Il montre également % comment utiliser au mieux les outils informatiques (Internet, Intranet, groupware) pour parvenir à gagner en efficacité au bureau. Parce que les techniques qu'il propose ont été appliquées avec succès par plus d'1 million de personnes dans le monde, ce livre vous aidera vraiment. Grâce à ce livre vous apprendrez à : ° Mieux gérer votre emploi du temps en fonction de vos priorités, de vos responsabilités et de vos objectifs en établissant votre «carte de responsabilités» et en apprenant à déléguer. ° Mieux organiser le rangement des documents sur votre bureau, dans votre messag...

  20. Actualites therapeutiques en pneumologie

    OpenAIRE

    Louis, Renaud; Bosquee, Léon; DUYSINX, Bernard; Corhay, Jean-Louis

    2007-01-01

    We review what we think to be the major advances in the field of respiratory medicine over the last ten years. We concentrate here on four major diseases i.e. asthma, chronic obstructive pulmonary disease (COPD), lung cancer and chronic respiratory insufficiency due to restrictive disorders. Therapeutic advances are based either on new drugs or on new disease management concepts and, in some cases, on new medical devices. These advances have allowed a reduction in mortality and morbidity in a...

  1. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells; Approches therapeutiques du syndrome hematopoietique apres irradiation globale accidentelle grave. Interet de l`expansion ex vivo des cellules hematopoietiques

    Energy Technology Data Exchange (ETDEWEB)

    Thierry, D.

    1994-12-31

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too.

  2. A case of severe congenital kyphoscoliosis secondary to multiple bilateral thoracic pedicle aplasia

    Energy Technology Data Exchange (ETDEWEB)

    Geoffray, Anne; Leloutre, Beatrice; Albertario, Marco; Bechard-Sevette, Nancy [Fondation Lenval Children' s Hospital, Department of Pediatric Imaging, Nice (France); Clement, Jean-Luc [Fondation Lenval Children' s Hospital, Department of Orthopedic and Spine Surgery, Nice (France)

    2008-07-15

    A 9-month-old boy with congenital kyphoscoliosis secondary to multiple bilateral thoracic pedicle aplasias is presented. This anomaly has rarely been described in the literature. Plain films showed absence of thoracic pedicles bilaterally from T2 to T9, which was better demonstrated on CT multiplanar and 3-D reformatted images. There were no neurological symptoms even though the deformity progressed rapidly. Congenital kyphosis or kyphoscoliosis is often related to spinal anomalies that are located on the anterior aspect of the vertebrae. However, posterior anomalies may also be responsible and should be recognized before neurological complications occur. (orig.)

  3. Prenatal ultrasonography of trisomy 18 with radial aplasia: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jee Young; Lee, Yeon Hee [Dankook University College of Medicine, Seoul (Korea, Republic of)

    2002-06-15

    Trisomy 18 (Edward syndrome) is the second most common chromosomal anomaly of the autosomal trisomy. Prenatal diagnosis of trisomy 18 is extremely important because of the complex malformations and lethal prognosis. Prenatal sonographic findings at 17 weeks of gestation showing radial aplasia with upper limb contracture, omphalocele, and suspicious esophageal atresia suggested the diagnosis and led to amniocentesis. Karyotyping revealed trisomy 18 (47 XX, +18, and characteristic autopsy findings were identified. We report a case of prenatally diagnosed trisomy 18 with a review of literatures.

  4. [Aplasia and hypoplasia of the side of the nose in the Mocha Period and today].

    Science.gov (United States)

    Pirsig, W

    1989-01-01

    In earthenware vessels from the Moche period (200-700 A.D.) pathological findings of nasal deformities have been depicted in a realistic manner. By means of two recent casuistics and of two portrait vessels of Old Peru it is demonstrated how exactly the nasal pathology was observed by the artists of the Moche period. The first example shows a unilateral hypoplasia of the nasal ala due to injury in early childhood, the second example shows a bilateral aplasia of the nasal alae due to an intrauterine growth disturbance. PMID:2690796

  5. [Bilateral deep venous thrombosis and vena cava aplasia treated with local thrombolysis

    DEFF Research Database (Denmark)

    Pelta, A.M.; Jørgensen, Maja; Just, Sven Richardt Lundgren;

    2008-01-01

    In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete thr...... thrombus resolution and no valvular incompetence at three months follow-up. In our opinion this treatment should be offered even in complex cases of acute proximal deep venous thrombosis Udgivelsesdato: 2008/5/19...

  6. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    OpenAIRE

    E. Bulliorsky; C. Shanley; G. Stemmelin; J. Ceresetto; O. Rabinovich

    2002-01-01

    El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH) con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoy...

  7. [Aplasia and hypoplasia of the optic nerve. Comparison of 2 cases].

    Science.gov (United States)

    Pisaturo, C; Dolci, A; Pessagno, A; Padua, G L; Dassio, D A; De Negri, M

    1996-10-01

    Hypoplasia and aplasia of the optic nerve are congenital anomalies characterized respectively by a marked volume reduction (very small papilla, often identifiable only as a rosy-yellowish area from which the retinal vessels emerge) and by the absence of the optic disk (absence of the nerve and mainly of its vessels) and of the visual functions. These anomalies are often associated with malformations of the central nervous system and of the ocular structures. The defects originate in the embryonal period due to the arrested development of the mesodermal component towards the head of the optic nerve. The aim of this study is to try to interpret the different clinical manifestations of the disease by observing two cases (a female and a male) with a clinical picture of aplasia and hypoplasia of the optic nerve respectively. Both cases presented the following clinical characteristics: developmental defects of the optic nerve, severe microcephaly, positive IgG antibodies against CMV. The association of the optic nerve defect with microcephaly is due to the embryogenic origin of the optic vescicle by prosencephalon. The resulting clinical picture is probably the outcome of an interfering process that the authors have presumed in CMV intrauterine infection, after having excluded the most frequent teratogenic agents (maternal diabetes, tabagism, intake of alcohol ad drugs). Moreover, the different degree of ocular involvement and the different time of onset of the intrauterine pathogenic insult in the two cases could account for the different clinical pictures. PMID:9053727

  8. Introduction : sentiments d’efficacité personnelle et orientation scolaire et professionnelle1

    OpenAIRE

    Blanchard, Serge

    2011-01-01

    Ce numéro spécial poursuit quatre objectifs : Présenter la théorie des sentiments d’efficacité personnelle (SEP) – qui s’insère dans le cadre plus général de la théorie sociale cognitive (TSC) d’Albert Bandura – et les principaux résultats des recherches qu’elle a suscitées depuis vingt-cinq ans aux États-Unis dans le domaine de l’orientation scolaire et professionnelle.L’article de Stephen Brewer présente d’abord une biographie d’Albert Bandura puis une brève introduction à ses travaux. Il d...

  9. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.

  10. Estimation de l'efficacité de systèmes ternaires Estimating the Efficiency of Tenary Systems

    Directory of Open Access Journals (Sweden)

    Castells Pique F.

    2006-11-01

    Full Text Available Les efficacités de Murphree et de vaporisation d'un système ternaire (Benzène-Heptane-Toluène sont déterminées expérimentalement et à partir de corrélations, en fonction de nombres sans dimension, établies pour les trois binaires correspondants. Les profils de concentration mesurés dans une colonne pilote de 10 plateaux perforés et les profils calculés en tenant compte de l'efficacité estimée à l'aide des corrélations sont en bon accord, ce qui permet d'envisager l'utilisation de certaines méthodes de prédiction d'efficacité de systèmes binaires pour des systèmes complexes. Murphree and vaporisation efficiency for a ternary system (Benzène-Heptane-Toluene are determined byexperimentsand from dimensionless correlations established for the three corresponding binary systems. Calculated and experiment concentration profiles are compared for a perforated plate pilot column. Calculated profiles are determined with efficiency estimated from the binary system efficiency correlations. Comparison givesa good concordance, sa its possible ta ihink of using someof binary efficiency prediction methods for multicomponent systems.

  11. Successful rescue of pure red cell aplasia in two aged patients undergoing pancrease-kindey transplantation

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yin-fu; YANG Tong-han; WANG Qing-yu; Wang Ping-xian; Fan Ming-qi; Feng Jia-yu

    2001-01-01

    To explore the correlation between hypoimmunity and the occurrence of pure red cell aplasia (PRCA) in senile patients undergoing combined pancrease-kindey transplantation. Methods: PRCA occurred in 2 patients out of 5 who were performed combined pancrease-kindey transplantation.The general scheme of treatment mainly included selective administration of immunosuppressants and antivirus drugs, infusion of red blood cells on the basis of surveillance of parvorirus B19 and the ratio of T4 and T8 as well as the changes of the myelogram.Results: The myelogram of the patients returned to normal in 2 and 3 weeks after operation, respectively, and subsequent follow-up revealed no recurrence. Conclusion: This series illustrate the point that advanced age, hypo immunity, parvorirus B19 and immunosuppressants are vulnerable to PRCA. Combined treatment is an effectiveremedy for these patients.

  12. Post renal transplant pure red cell aplasia-is tacrolimus a culprit?

    Science.gov (United States)

    Patil, Malagouda R; Choudhury, Arpita Roy; Chohwanglim, Manong; Divyaveer, Smita; Mahajan, Chetan; Pandey, Rajendra

    2016-08-01

    Anemia is not uncommon in the post-renal transplant period and has been reported in up to 40% of renal transplant recipients. It is commonly due to drugs and infections. While post-transplantation anemia is usually due to graft dysfunction and drugs such as mycophenolate and cotrimoxazole, tacrolimus is an uncommon cause. Tacrolimus is usually not believed to be significantly myelosuppressive, but it can cause anemia due to thrombotic microangiopathy. A literature review shows a very small number of reported cases of pure red cell aplasia (PRCA) where tacrolimus seemed to be a causative agent. We report a case series of three renal transplant recipients who were on tacrolimus and presented with chronic transfusion requiring anemia due to PRCA. PMID:27478605

  13. MURCS (Müllerian duct aplasia-renal agenesis-cervicothoracic somite dysplasia): a rare cause of primary amenorrhoea.

    Science.gov (United States)

    Kumar, Sunil; Sharma, Shruti

    2016-04-01

    The agenesis of the Müllerian duct is the second most common cause of primary amenorrhoea after Turner syndrome. The abnormal development of Müllerian duct often associates with the urinary tract and skeletal abnormalities. MURCS (Müllerian duct aplasia-renal agenesis-cervicothoracic somite dysplasia) association is a unique and rare developmental disorder with four common features of uterine hypoplasia or aplasia, renal agenesis or ectopy, vertebral anomalies and short stature. We report a case of young female with primary amenorrhoea. She had well-developed secondary sexual characteristics along with multiple congenital developmental abnormalities such as the absence of uterus, ectopic kidney, cervical vertebral fusion, hemivertebrae, scoliosis, cervical rib, facial asymmetry and growth retardation. Our case highlights the rarity and clinical importance of this syndrome. For the evaluation of primary amenorrhoea in a female with well-developed secondary sexual characteristics, congenital anomalies should be ruled out before hormone and karyotype analyses. PMID:27099773

  14. Incidental finding of unilateral isolated aplasia of serratus anterior muscle and winged scapula on chest radiograph: A case report

    International Nuclear Information System (INIS)

    The isolated aplasia of the serratus anterior muscle with winging of scapula is very rare, and only a few cases are reported. Here, we present a case of a 30-year-old Korean male who initially presented with a left flank pain. His physical exam did not show any significant finding in his right shoulder. However, his chest radiograph showed absence of right serratus anterior muscle and slightly elevated and medially rotated right scapula. Subsequent CT scan showed the right serratus anterior muscle aplasia and medial winging of the right scapula. This case is unique in two aspects. First, the combination of abnormalities is different from the typical congenital abnormalities involving shoulder girdle, such as Sprengel deformity or Poland syndrome. Secondly, this was incidentally diagnosed with chest radiograph, without clinical impression. Careful reading of chest radiograph can help the radiologists to detect such clinically silent abnormalities.

  15. Aplasia transitória da série vermelha na anemia falciforme Transient red cell aplasia in sickle cell disease

    Directory of Open Access Journals (Sweden)

    Mônica P. A. Veríssimo

    2007-09-01

    Full Text Available A doença falciforme, devido à vida média encurtada das hemácias, pelo quadro de hemólise crônica, pode apresentar um quadro clínico grave de anemia quando ocorre supressão da eritropoese devida à infecção pelo Parvovírus humano B19. O quadro clínico apresenta-se com febre, que pode preceder a anemia grave, fraqueza e mal- estar, além de sinais laboratoriais como queda da hemoglobina e reticulocitopenia importante. Diagnóstico laboratorial pode ser por imunofluorescência ou ensaio enzimático. O tratamento é a transfusão de concentrado de hemácias. Pode haver complicações associadas a esta infecção, tais como seqüestro esplênico, seqüestro hepático, síndrome torácica aguda, síndrome nefrótica, meningoencefalite e acidente vascular cerebral. Estratégias de prevenção poderão mudar a morbi-mortalidade desta condição no paciente portador de doença falciforme.Sickle cell disease due to shortened life span of red blood cells by hemolysis, may present with severe anemia when erythropoietic suppression occurs due to infection by the Human parvovirus B19. The clinical presentation presents with fever, which may precede transient red cell aplasia, as well as laboratorial signs such as a drop in hemoglobin and significant reticulo cytopenia. Laboratorial diagnosis may be by immunofluorescence or enzymatic assays. Treatment is achieved by transfusion of packed red blood cells. Complications may be associated to this infection, including splenic and hepatic sequestration, acute chest syndrome, nephrotic syndrome, meningoencephalitis and strokes. Strategies of prevention are able to change the morbidity and mortality of this condition in sickle cell disease patients.

  16. Further development of a model of chronic bone marrow aplasia in the busulphan-treated mouse.

    Science.gov (United States)

    Turton, John A; Sones, William R; Andrews, Charles M; Pilling, Andrew M; Williams, Thomas C; Molyneux, Gemma; Rizzo, Sian; Gordon-Smith, Edward C; Gibson, Frances M

    2006-02-01

    Aplastic anaemia (AA) in man is an often fatal disease characterized by pancytopenia of the peripheral blood and aplasia of the bone marrow. AA is a toxic effect of many drugs and chemicals (e.g. chloramphenicol, azathioprine, phenylbutazone, gold salts, penicillamine and benzene). However, there are no widely used or convenient animal models of drug-induced AA. Recently, we reported a new model of chronic bone marrow aplasia (CBMA = AA) in the busulphan (BU)-treated mouse: eight doses of BU (10.50 mg/kg) were administered to female BALB/c mice over a period of 23 days; CBMA was evident at day 91/112 post-dosing with significantly reduced erythrocytes, platelets, leucocytes and nucleated bone marrow cell counts. However, mortality was high (49.3%). We have now carried out a study to modify the BU-dosing regime to induce CBMA without high mortality, and investigated the patterns of cellular responses in the blood and marrow in the post-dosing period. Mice (n = 64/65) were dosed 10 times with BU at 0 (vehicle control), 8.25, 9.0 and 9.75 mg/kg over 21 days and autopsied at day 1, 23, 42, 71, 84, 106 and 127 post-dosing (n = 7-15); blood and marrow samples were examined. BU induced a predictable bone marrow depression at day 1 post-dosing; at day 23/42 post-dosing, parameters were returning towards normal during a period of recovery. At day 71, 84, 106 and 127 post-dosing, a stabilized, late-stage, nondose-related CBMA was evident in BU-treated mice, with decreased erythrocytes, platelets and marrow cell counts, and increased MCV. At day 127 post-dosing, five BU-treated mice showed evidence of lymphoma. In this study, mortality was low, ranging from 3.1% (8.25 mg/kg BU) to 12.3% (9.75 mg/kg BU). It is concluded that BU at 9.0 mg/kg (or 9.25 mg/kg) is an appropriate dose level to administer (10 times over 21 days) to induce CBMA at approximately day 50-120 post-dosing.

  17. High dose ionizing irradiation induces an early and transient increase in peripheral blood hematopoietic progenitor cells; L`exposition aigue aux radiations ionisantes induit un recrutement transitoire des progeniteurs hematopoietiques au niveau du sang peripherique: implications therapeutiques potentielles

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Vetillard, J.; Chauvelot, F.; Thierry, D.; Mestries, J.C.; Herodin, F. [Centre de Recherches du Service de Sante des Armees, La Tronche, 38 - Grenoble (France)]|[Centre de Recherches du Service de Sante des Armees - Centre d`Etudes Nucleaires de Fontenay-aux-Roses, 92 (France)

    1997-12-31

    Nonhuman primates exposed to ionizing radiation exhibit an early and transient increase in peripheral blood committed hematopoietic progenitor cells. The management of bone marrow aplasia secondary to accidental irradiation could be based in part on the re-infusion of those circulating autologous progenitors following a period of ex vivo expansion with cytokines. (authors)

  18. Spontaneous hematologic recovery from bone marrow aplasia after accidental tenfold overdosage with radiophosphorus

    Energy Technology Data Exchange (ETDEWEB)

    Gmuer, J.; Bischof, B.; Coninx, S.; Bucher, U.; Poretti, G.; Henrichs, K.; Kaul, A.; Roedler, H.D.; Buettner, K.; Frick, P.G.

    1983-04-01

    Two patients with polycythemia vera received intravenously an accidental tenfold overdosage of radiophosphorus therapy (60 and 50 mCi 32P, respectively). In both patients, the occurrence of hemorrhagic complications 3 wk after the 32P medication led to detection of the error and referral to our hospital. Upon admission they showed an agranulocytosis, severe thrombocytopenia, and bone marrow aplasia. In both cases, spontaneous recovery of the hematopoiesis was observed from day 40 posttreatment onward. In one patient, a slow but ultimately complete normalization of blood counts and marrow morphology took place, whereas in the other, a mild thrombocytopenia persists. Nearly 5 yr after the accidental overdosage, both patients are clinically well. Symptoms of polycythemia vera have not reappeared up to now. Attempts were made to evaluate the radiation dose absorbed by the bone marrow. In the first patient, the daily 32P excretion was determined from day 22 to day 60, whereas in the other patient a whole body count was performed on day 78 after administration. From these results, an approximate cumulative bone marrow dose of 10 Sv (1000 rem) could be calculated.

  19. Common crus aplasia: diagnosis by 3D volume rendering imaging using 3DFT-CISS sequence

    Energy Technology Data Exchange (ETDEWEB)

    Kim, H.J. E-mail: hakjink@pusan.ac.kr; Song, J.W.; Chon, K.-M.; Goh, E.-K

    2004-09-01

    AIM: The purpose of this study was to evaluate the findings of three-dimensional (3D) volume rendering (VR) imaging in common crus aplasia (CCA) of the inner ear. MATERIALS AND METHODS: Using 3D VR imaging of temporal bone constructive interference in steady state (CISS) magnetic resonance (MR) images, we retrospectively reviewed seven inner ears of six children who were candidates for cochlear implants and who had been diagnosed with CCA. As controls, we used the same method to examine 402 inner ears of 201 patients who had no clinical symptoms or signs of sensorineural hearing loss. Temporal bone MR imaging (MRI) was performed with a 1.5 T MR machine using a CISS sequence, and VR of the inner ear was performed on a work station. Morphological image analysis was performed on rotation views of 3D VR images. RESULTS: In all seven cases, CCA was diagnosed by the absence of the common crus. The remaining superior semicircular canal (SCC) was normal in five and hypoplastic in two inner ears, while the posterior SCC was normal in all seven. One patient showed bilateral symmetrical CCA. Complicated combined anomalies were seen in the cochlea, vestibule and lateral SCC. CONCLUSION: 3D VR imaging findings with MR CISS sequence can directly diagnose CCA. This technique may be useful in delineating detailed anomalies of SCCs.

  20. Unilateral multifocal testicular biopsies in 320 patients with germ cell aplasia

    Directory of Open Access Journals (Sweden)

    D Jamali Zavareii. M

    2007-05-01

    Full Text Available Background: Germ cell aplasia (G.C.A is one of the most important testicular causes of infertility and azospermia.In this condition the seminiferous tubules are only lined by a single layer of sertoli cell. In some cases, there is focal area with spermatogenic activity. Methods: We studied infertile men with G.C.A referred to Jahade Daneshgahi of Iran during 1381-82, retrospectively. All the cases had more than one biopsy of one testis. Results: In 11.6٪ of 320 cases, comparison of multiple biopsy sites of a testis revealed: when one site showed G.C.A, another site revealed areas with spermatogenic activity. Considering the cases who showed germ cells in both sites, 15.3٪ of cases multiple biopsy sites appeared to have focal spermatogenesis, better maturation of germ cells or higher scoring area for urologic operation. Conclusion: According to new techniques in treatment of infertility with ICSI (intra cytoplasmic sperm injection in which fertility is possible with one spermatozoa or even spermatid (after recovery, biopsy of multiple sites instead of only one site is highly recommended in azospermic patient.

  1. Analyse de l'efficacité de l'accoutumance à l'eau chez l'enfant préscolaire

    OpenAIRE

    Mornard, Manhattan; Deflandre, Dorian; Delvaux, Anne; Cloes, Marc; Jidovtseff, Boris

    2014-01-01

    L'accoutumance à l'eau apparaît comme un prérequis indispensable à l'apprentissage des techniques de nage. Après différents tests chez des enfants en bas âge, l'étude confirme l'efficacité à l'accoutumance à l'eau. Peer reviewed

  2. Epoetin-associated pure red cell aplasia: past, present, and future considerations

    Science.gov (United States)

    McKoy, June M.; Stonecash, Robin E.; Cournoyer, Denis; Rossert, Jerome; Nissenson, Allen R.; Raisch, Dennis W.; Casadevall, Nicole; Bennett, Charles L.

    2009-01-01

    BACKGROUND Since 1988, millions of patients have received epoetin products intravenously (IV) and subcutaneously. In 1998, epoetin-associated pure red cell aplasia (PRCA) was first reported and causation was attributed to formulations without human serum albumin (HSA), subcutaneous administration, and uncoated rubber stoppers. STUDY DESIGN AND METHODS Data on erythropoietin (EPO)-associated PRCA were obtained from the Food and Drug Administration (FDA), regulatory authorities in other countries, and the manufacturers of epoetin alfa, epoetin beta, and darbepoetin. The data included information on numbers of PRCA cases and estimated exposure-adjusted incidence rates by EPO product, anemia etiology, administration route, country of PRCA identification, and date reported. RESULTS In 1999, academicians in Paris identified 12 EPO-treated patients with antibody-mediated PRCA; 11 of these patients were on hemodialysis and had received subcutaneous Eprex (Johnson & Johnson). In 2002, authorities in Europe, Australia, Singapore, and Canada mandated Eprex by IV route to hemodialysis patients, and the relevant manufacturers added Teflon coating to prefilled syringes of Eprex; PRCA cases subsequently decreased by 90 percent. By 2003, 180 Eprex-associated PRCA cases were identified in Europe, Canada, Australia, and Asia, despite improvements in handling. Since 2002, FDA safety databases include information on 59 new cases of antibody-associated PRCA, primarily associated with subcutaneous epoetin alfa and darbepoetin that does not contain HSA. CONCLUSION Independent actions by regulatory authorities, manufacturers, and academic researchers identified significant numbers of PRCA cases between 1998 and 2003 and characterized the probable etiology. Today, antibody-mediated PRCA is an infrequent class toxicity occurring among some hemodialysis patients on EPOs. PMID:18482185

  3. A patient with isochromosome 18q, radial-thumb aplasia, thrombocytopenia, and an unbalanced 10;18 chromosome translocation.

    Science.gov (United States)

    Sahoo, Trilochan; Naeem, Rizwan; Pham, Kim; Chheng, Sou; Noblin, Sarah T; Bacino, Carlos A; Gambello, Michael J

    2005-02-15

    We report on the clinical and cytogenetic findings in a newborn with a de novo isochromosome 18q. Radial/thumb aplasia and thrombocytopenia were significant features in addition to multiple congenital anomalies. Comparison with reported cases suggests that the genes for such features are located on the 18q arm. An additional finding of a non-reciprocal translocation between chromosome 18p telomere and chromosome 10q telomere was also observed in a majority of cells examined. This additional rearrangement likely has minimal phenotypic consequences, but does raise the possibility that cryptic translocations of telomeric ends of the deleted arm in isochromosome cases may be more common than appreciated.

  4. Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management.

    Science.gov (United States)

    Sawlani, Kamal Kumar; Chaudhary, Shyam Chand; Singh, Jitendra; Raja, Deep Chandh; Mishra, Sanjay; Goel, Madhu Mati

    2016-01-01

    Dapsone (4,4'- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone. PMID:27512715

  5. Noncanonical Wnt5a-Ca(2+) -NFAT signaling axis in pesticide induced bone marrow aplasia mouse model: A study to explore the novel mechanism of pesticide toxicity.

    Science.gov (United States)

    Chattopadhyay, Sukalpa; Chatterjee, Ritam; Law, Sujata

    2016-10-01

    According to case-control studies, long-term pesticide exposure can cause bone marrow aplasia like hematopoietic degenerative disease leading to impaired hematopoiesis and increased risk of aplastic anemia in human subjects. However, the exact mechanism of pesticide mediated hematotoxicity still remains elusive. In this study, we investigated the role of noncanonical Wnt signaling pathway, a crucial regulator of adult hematopoiesis, in pesticide induced bone marrow aplasia mouse model. Aplasia mouse model was developed following inhalation and dermal exposure of 5% aqueous mixture of common agriculturally used pesticides for 6 h/day for 5 days a week up to 90 days. After that, blood hemogram, marrow smear, cellularity, scanning electron microscopy, extramedullary hematopoiesis and flowcytometric expression analysis of noncanonical Wnt signaling components, such as Wnt 5a, fzd5, NFAT, IFN-γ, intracellular Ca(2+) level were evaluated in the bone marrow hematopoietic stem/progenitor compartment of the control and pesticide induced aplasia groups of animals. Results showed that pesticide exposed mice were anemic with peripheral blood pancytopenia, hypocellular degenerative marrow, and extramedullary hematopoiesis in the spleen. Upon pesticide exposure, Wnt 5a expression was severely downregulated with a decline in intracellular Ca(2+) level. Moreover, downstream of Wnt5a, we observed sharp downregulation of NFATc2 transcription factor expression, the major target of pesticide toxicity and its target molecule IFN-γ. Taken together, our result suggests that deregulation of Wnt5a-Ca(2+) -NFAT signaling axis in the hematopoietic stem/progenitor compartment plays a crucial role behind the pathogenesis of pesticide mediated bone marrow aplasia by limiting primitive hematopoietic stem cells' ability to maintain hematopoietic homeostasis and reconstitution mechanism in vivo during xenobiotic stress leading to ineffective hematopoiesis and evolution of bone marrow aplasia.

  6. Hematopoiesis stimulation test by interleukin 1α gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation

    International Nuclear Information System (INIS)

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  7. Alberto Fujimori : le populisme de l’efficacité

    Directory of Open Access Journals (Sweden)

    Diana Burgos-Vigna

    2005-09-01

    Full Text Available À la tête du Pérou de 1990 à 2000, Alberto Fujimori a su rester populaire en combinant les recettes traditionnelles et nouvelles du populisme. Le discrédit des partis politiques et des syndicats a constitué un contexte favorable à l’arrivée et au maintien au pouvoir de ce non-professionnel de la politique, auquel des valeurs d’honnêteté et de compétence ont été spontanément prêtées. Le chef d’Etat péruvien a construit en outre, tout au long de ses mandats successifs, une stratégie politique destinée à asseoir sa légitimité. Cette stratégie s’est fondée sur des actions telles que : la mise en place d’une relation directe et quasi affective avec les couches les plus défavorisées de la population par le biais de pratiques clientélistes ; la déstructuration du tissu social dans l’objectif d’éviter toute opposition et de renforcer le pouvoir du chef de l’Etat ; l’instrumentalisation de certains groupes d’acteurs, notamment par l’intermédiaire des programmes sociaux ; enfin, le contrôle permanent, et sans cesse renforcé, de l’information, via la surveillance des médias et des opposants. Fondée sur une image d’efficacité, la gestion politique d’Alberto Fujimori est demeurée populaire jusqu’à la fin des années 1990, lorsque la révélation d’affaires de corruption a accéléré la chute de son régime.Presidente de Perú de 1990 a 2000, Alberto Fujimori supo conservar su popularidad mezclando viejas y nuevas recetas del populismo. El descrédito de los partidos políticos y de los sindicatos dibujó el contexto idóneo a la llegada y al mantenimiento al poder de este outsider de la política, al cual muy pronto fueron asociados valores de honestidad y de competencia. El jefe del Estado peruano supo además, a lo largo de sus mandatos sucesivos, construir una estrategia política cuyo objetivo era el asentamiento de su legitimidad. Esta estrategia se fundó principalmente en las

  8. Aplasia medular após transplante hepático em pediatria Aplastic anemia after pediatric liver transplantation

    Directory of Open Access Journals (Sweden)

    Marlene P. Garanito

    2009-01-01

    Full Text Available A aplasia de medula é uma das mais raras (Aplastic anemia (AA is one of the rarest (<1% and most serious complications of liver transplantation for fulminant non-A, non-B and non-C hepatitis. It was first described in 1987 by Stock; the mechanism involved is an immunologically mediated condition secondary to an unknown viral infection. The disease is associated with a dismal prognosis. Spontaneous recovery from acquired AA is very rare however some patients (50-70% recover after immunosuppressive therapy, such as Cyclosporin A (CsA and Antithymocyte globulin (ATG, even after liver transplantation. Another treatment option is bone marrow transplantation. We report on a child who developed AA following liver transplantation for fulminant viral hepatitis that was treated with intensive immunosuppression including CsA and ATG and achieved complete recovery.

  9. Améliorer votre efficacité techniques d'aujourd'hui pour en faire plus en moins de temps

    CERN Document Server

    Savoyat, Bruno

    2012-01-01

    Quels que soient votre fonction, votre métier ou votre mission dans l'entreprise, ce livre pragmatique peut vous ouvrir les chemins d'une nouvelle vie. Il a été conçu et écrit pour vous rendre service et pour vous aider à gagner en efficacité. Les meilleures pratiques y ont été retenues pour vous. Certaines sont utilisées avec succès par plus d'un million de personnes à travers le monde. Leur mise en oeuvre est simple pour un impact maximal sur votre productivité, sur la qualité de votre travail et sur la satisfaction que vous retirerez de votre quotidien professionnel. Les principes et les conseils d'efficacité décrits dans ce livre peuvent être appliqués seul comme en équipe, et être généralisés à l'ensemble d'une entreprise. Vous pouvez choisir de les découvrir par une lecture du début à la fin, qui vous permettra une révision systématique de votre manière de travailler et de votre potentiel de gains en efficacité. Mais vous pouvez également opter pour une découverte théma...

  10. A rare presentation of aplasia cutis congenita after feto-reduction in a trichorionic-triamniotic pregnancy.

    Science.gov (United States)

    Vettori, D J; Jairath, P

    2015-01-01

    Aplasia cutis congenita (ACC) is rare skin disorder of newborns that has been linked to both assisted reproductive technology (ART) and feto-reduction procedures. ACC is characterized by well-demarcated lesions that are devoid of all skin layers. Group-V ACC presents with a distinctive and symmetrical distribution pattern. It is thought to result from an insult to the fetus after concomitant twin demise and is almost exclusively reported in monochorionic gestations.A 41-year-old female with an in vitro fertilization (IVF) assisted tri-chorionic gestation subsequently underwent selective feto-reduction of Fetus C. The patient delivered two pre-term neonates secondary to pre-eclampsia. The initial exam of Twin B showed extensive, well-demarcated, symmetrical areas devoid of any skin over the anterior and lateral trunk, extending up the lateral thoracic walls. Chest and abdominal viscera were visible through a thin fibrous membrane. The skin defects were managed conservatively with twice-daily dressings of Aquaphor, and Vaseline gauze. The areas of aplasia slowly contracted, though residual scarring was noted. After four weeks in the NICU, most of the areas were healed.ACC in multi-fetal pregnancies is a rare, but well-described complication. This is, to our knowledge, the first reported case in a tri-chorionic IVF gestation after feto-reduction. With increased incidence of ART-associated pregnancies and the use of feto-reduction for higher order gestations, this may become more common. Neonates often require specialized intensive care. Conservative management usually will suffice, although surgical grafting may be required. Physicians should be aware of this condition and counsel their feto-reduction patients of the risk. PMID:26485557

  11. CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia.

    Directory of Open Access Journals (Sweden)

    Marco L Davila

    Full Text Available Although many adults with B cell acute lymphoblastic leukemia (B-ALL are induced into remission, most will relapse, underscoring the dire need for novel therapies for this disease. We developed murine CD19-specific chimeric antigen receptors (CARs and an immunocompetent mouse model of B-ALL that recapitulates the disease at genetic, cellular, and pathologic levels. Mouse T cells transduced with an all-murine CD3ζ/CD28-based CAR that is equivalent to the one being used in our clinical trials, eradicate B-ALL in mice and mediate long-term B cell aplasias. In this model, we find that increasing conditioning chemotherapy increases tumor eradication, B cell aplasia, and CAR-modified T cell persistence. Quantification of recipient B lineage cells allowed us to estimate an in vivo effector to endogenous target ratio for B cell aplasia maintenance. In mice exhibiting a dramatic B cell reduction we identified a small population of progenitor B cells in the bone marrow that may serve as a reservoir for long-term CAR-modified T cell stimulation. Lastly, we determine that infusion of CD8+ CAR-modified T cells alone is sufficient to maintain long-term B cell eradication. The mouse model we report here should prove valuable for investigating CAR-based and other therapies for adult B-ALL.

  12. Clinical importance of digitized chest X-ray for detection of pulmonary infiltrations in bone marrow transplant patients during aplasia

    International Nuclear Information System (INIS)

    Purpose: Evaluation of digitized chest X-ray for the detection of pulmonary infiltrations in bone marrow transplant patients during aplasia. Methods: Digitized chest X-rays of 40 patients (21 female, 19 male) with 'Fever of unknown origin' (FUO) were evaluated concerning radiological signs of pulmonary infiltrations and correlated to clinical findings, blood chemistry, microbiology and bronchoscopy. Additionally, an individual risk profile was established. Results: In 11/40 patients pulmonary infiltrations were detected in digitized chest X-rays (group 1). 10/11 developed an infectious pulmonary infiltration. 29/40 patients developed no pulmonary infiltration (group 2). When fever increased for the first time (initial chest X-ray) a sensitivity, specificity, positive and negative predictive value of 46%, 86%, 56%, 81% and for the chest X-rays in process of 61%, 79%, 68% and 73% was found. C-reactive protein and temperature increase occured statistically significantly earlier (p<0.05) in group 1 compared to group 2. The average latency of digital chest X-rays in comparison to c-reactive protein and temperature increase was 6 days. The incidence of risk factors was significantly higher in group 1 in comparison to group 2 (p<0.05). Conclusion: Digitized chest X-rays are not a reliable method for primary detection of pulmonary infiltrations after bone marrow transplantation. Individual risk factors have to be taken into consideration to indicate further diagnostic methods such as computed tomography at an earlier time. (orig.)

  13. Improvement in Erythropoieis-stimulating Agent-induced Pure Red-cell Aplasia by Introduction of Darbepoetin-α When the Anti-erythropoietin Antibody Titer Declines Spontaneously

    OpenAIRE

    Lee, Hajeong; Yang, Jaeseok; Kim, Hyosang; Kwon, Ju Won; Oh, Kook-Hwan; Joo, Kwon Wook; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Kim, Suhnggwon

    2010-01-01

    Anti-erythropoietin antibodies usually cross-react with all kinds of recombinant erythropoietins; therefore, erythropoiesis-stimulating agent (ESA)-induced pure red-cell aplasia (PRCA) is not rescued by different ESAs. Here, we present a case of ESA-induced PRCA in a 36-yr-old woman with chronic kidney disease, whose anemic condition improved following reintroduction of darbepoetin-α. The patient developed progressive, severe anemia after the use of erythropoietin-α. As the anemia did not imp...

  14. Amelioration de l'efficacite energetique du procede d'electrolyse de l'aluminium conception d'un nouveau bloc cathodique

    Science.gov (United States)

    Blais, Mathieu

    Au Quebec, les alumineries sont de grandes consommatrices d'energie electrique, soit pres de 14 % de la puissance installee d'Hydro-Quebec. Dans ce contexte, des petits gains en efficacite energetique des cuves d'electrolyse pourraient avoir un impact important sur la reduction globale de la consommation d'electricite. Le projet de maitrise decrit dans cette etude repond a la problematique suivante : comment l'optimisation de la geometrie d'un bloc cathodique en vue d'uniformiser la densite de courant peut augmenter l'efficacite energetique et la duree de vie de la cuve d'aluminium? Le but premier du projet est de modifier la geometrie en vue d'ameliorer le comportement thermoelectrique des blocs cathodiques et d'accroitre par le fait meme l'efficacite energetique du procede de production d'aluminium. La mauvaise distribution de la densite de courant dans la cuve est responsable de certains problemes energetiques ayant des impacts negatifs sur l'economie et l'environnement. Cette non-uniformite de la distribution du courant induit une usure prematuree de la surface de la cathode et contribue a reduire la stabilite magnetohydrodynamique de la nappe de metal liquide. Afin de quantifier les impacts que peut avoir l'uniformisation de la densite de courant a travers le bloc cathodique, un modele d'un bloc cathodique d'une cuve de la technologie AP-30 a ete concu et analyse par elements finis. A partir de son comportement thermoelectrique et de donnees experimentales d'une cuve AP-30 tirees de la litterature, une correlation entre le profil de densite de courant a la surface du bloc et le taux d'erosion local au meme endroit a ete creee. Cette relation correspond au modele predictif de la duree de vie de tout bloc du meme materiau a partir de son profil de densite de courant. Ensuite, une programmation a ete faite incorporant dans une meme fonction cout les impacts economiques de la duree de vie, de la chute de voltage cathodique et de l'utilisation de nouveaux materiaux

  15. Évaluation expérimentale de l'efficacité d'un candidat vaccin sous-unitaire contre le virus respiratoire syncytial bovin

    OpenAIRE

    Soulestin , Marion

    2009-01-01

    Une étude récente a démontré qu’un candidat vaccin sous unitaire composé d’anneaux formés par la nucléoprotéine recombinante du virus respiratoire syncytial humain (nanoparticules N-SRS) pouvait protéger des souris contre une inoculation d’épreuve (Roux et al., 2008). L’objectif de ce projet était d’évaluer l’efficacité de ce vaccin chez le veau, espèce cible naturelle du virus respiratoire syncytial bovin. Pour cela, 24 veaux séronégatifs vis-à-vis du virus et indemnes d’infectio...

  16. L’évolution des lithométéores en Mauritanie confirme une plus grande efficacité de l’action éolienne

    OpenAIRE

    Nouaceur, Zeineddine

    2001-01-01

    L’étude des lithométéores vise à donner un bilan chiffré de la situation en Mauritanie. L’observation de ces phénomènes atteste d’une tendance à la hausse très nette depuis les années soixante-dix, période à laquelle s’amorçaient les conditions pluviométriques drastiques. Dans la plupart des cas, une liaison étroite associe variabilité pluviométrique et fluctuation des observations des lithométéores. Cette tendance confirme une plus grande efficacité de l’action éolienne sur des substrats pro...

  17. Effets de l'adjonction de lipides dans la ration sur les performances de ponte et l'efficacité alimentaire de poules normales ou naines

    OpenAIRE

    Mérat P; Bordas A; El-Attar A

    1986-01-01

    Les performances de ponte et d’efficacité alimentaire ont été comparées pour des poules Leghorn de taille normale (Dw+) ou naines (dw) en présence de 2 régimes à teneurs différentes en lipides totaux. Le régime le plus riche a, dans l’ensemble, un effet négatif sur la variation de poids corporel des pondeuses, du moins pour les poules de taille normale. Pour les poules naines, d’autre part, l’intensité de ponte semble comparativement un peu plus améliorée par le régime enrichi en lipides q...

  18. Gouvernance et efficacité missionnaire de la Compagnie de Jésus : les enseignements d'une théorie élargie de la gouvernance

    OpenAIRE

    Wirtz, Peter

    2013-01-01

    La gouvernance de la Compagnie de Jésus se caractérise dès ses débuts par un certain nombre de particularités, dont le vœu d'obéissance au pape, l'importante autorité du préposé général, ainsi que l'esprit ignatien qui est transmis à travers les exercices spirituels à toutes les générations de jésuites. Dans le présent article, nous montrons que le système particulier de gouvernance de la jeune Compagnie joue un rôle déterminant dans l'efficacité missionnaire de l'ordre, grâce, notamment, à s...

  19. Energy efficiency; Efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-06-15

    This road-map proposes by the Group Total aims to inform the public on the energy efficiency. It presents the energy efficiency and intensity around the world with a particular focus on Europe, the energy efficiency in industry and Total commitment. (A.L.B.)

  20. New experimental approach to treatment of radiation-induced bone marrow aplasia: ex vivo expansion of hematopoietic cells; Nouvelle approche experimentale du traitement de l`aplasie medullaire radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Mathieu, J.; Drouet, M.; Grenier, N.; Grange, L.; Bourin, P.; Vetillard, J.; Thierry, D.; Mestries, J.C.

    1995-12-31

    The management of bone marrow aplasia secondary to accidental exposure to high doses of ionizing radiations requires new therapeutic protocols in addition to cytokine therapy. The in vitro incubation of hematopoietic stem and progenitor cells from irradiated nonhuman primates with negative and positive regulators of hematopoiesis may lead to helpful products of transfusion. (author).

  1. Metabolism of {sup 137}cesium, {sup 137}barium in the rat. Therapeutics of the contamination; Metabolisme du {sup 137}cesium, {sup 137}baryum chez le rat. Therapeutique de la contamination

    Energy Technology Data Exchange (ETDEWEB)

    Remy, J.; Philippon, A.; Lafuma, J.; Walter, C. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Departement de la Protection Sanitaire, Laboratoire de Radiopathologie

    1967-07-01

    'elimination du {sup 137}Cs - {sup 137}Ba chez le rat. Ils montrent l'independance de ces phenomenes vis-a-vis des modalites d'une administration unique. La distribution tend dans tous les cas vers un schema type qui se maintient ensuite identique a lui-meme en fonction de la charge corporelle. L'analyse biochimique de l'etat du cesium dans les milieux biologiques montre qu'il y est transporte sous une forme libre et ionisee. Abordant le probleme du mode de penetration de l'ion cesium dans le milieu intracellulaire et notamment par l'etude cinetique du systeme plasma-hematie in vivo et in vitro, les auteurs adoptent l'hypothese d'un transport actif du cesium par la membrane cellulaire. Ils en arrivent ainsi a un schema general de la distribution du cesium dans l'organisme, essentiellement caracterise par un equilibre dynamique de repartition entre deux compartiments: 99 pour cent du cesium est accumule dans le pool intracellulaire, 1 pour cent dans les liquides extracellulaires. Ce dernier compartiment est ouvert sur les emonctoires. Du fait du transport actif par les membranes cellulaires, la charge du pool intracellulaire est rapide, mais la decharge est lente. Ce phenomene est le facteur limitant de la decroissance de la charge corporelle. De ce schema les auteurs deduisent les raisons de l'echec relatif des diverses voies therapeutiques explorees a ce jour par eux-memes, et par d'autres auteurs. La stimulation des emonctoires naturels, dans le cas des diuretiques par exemple, ne saurait accroitre que l'epuration du compartiment extracellulaire. Or ce dernier ne contient que 1 pour cent de la charge corporelle et sa recharge est lente. En outre, les procedes visant a contrarier ou inhiber le transport actif du cesium par la membrane cellulaire restent, a ce jour, incompatibles avec la survie de la cellule. (auteurs)

  2. Efficacité technique des unités de production informelles: une approche de régressions quantiles. Le cas de l'agglomération d'Antananarivo

    OpenAIRE

    Faly Henry Rakotomanana

    2010-01-01

    Cette étude a pour objet d’analyser le degré l’efficacité technique des unités de production informelles et ses déterminants dans le cas de l’agglomération d’Antananarivo à Madagascar en utilisant les bases de données issues d’une série d’enquête de type 1-2-3 sur le secteur informel réalisées en 2001 et 2004. La méthode de la régression par quantile est retenue dans les modèles pour tenir compte des fortes disparités des unités en termes de performances. Le degré d’efficacité des unités de p...

  3. Quelle est l'efficacité et l'innocuité de l'utilisation de l'homéopathie en période périnatale ?: travail de Bachelor

    OpenAIRE

    Progin, Delphine; Hernandez, Marion; Nunno, Catia

    2013-01-01

    Ce travail a pour objectif d’évaluer l’efficacité et l’innocuité de l’homéopathie utilisée pendant la période périnatale, pour pouvoir permettre aux professionnels de la santé et plus particulièrement aux sages-femmes de conseiller et diriger avec plus de certitudes leurs patientes, qui en sont de grandes utilisatrices.

  4. Bone marrow pathology in dogs and cats with non-regenerative immune-mediated haemolytic anaemia and pure red cell aplasia.

    Science.gov (United States)

    Weiss, D J

    2008-01-01

    Many dogs and cats with immune-mediated haemolytic anaemia (IMHA) lack a bone marrow erythroid regenerative response. To better understand the failure of the bone marrow to respond to the anaemia, bone marrow pathology associated with non-regenerative IMHA and pure red cell aplasia (PRCA) was reviewed. Eighty-two affected dogs and 57 affected cats were identified from a population presenting to a referral hospital over a 10-year period. Fifty-five dogs had non-regenerative IMHA (38 had bone marrow erythroid hyperplasia and 17 had erythroid maturation arrest) and 27 had pure red cell aplasia (PRCA). Twenty-eight cats had non-regenerative IMHA (24 had erythroid hyperplasia and 4 had erythroid maturation arrest) and 29 had PRCA. A variety of pathological changes were observed in bone marrow aspirates and core biopsy specimens taken from these animals. These changes included dysmyelopoiesis, myelonecrosis, myelofibrosis, interstitial oedema, haemorrhage, acute inflammation, haemophagocytic syndrome, lymphocyte aggregation, and lymphocyte or plasma cell hyperplasia. In both dogs and cats, dysmyelopoiesis, myelonecrosis, myelofibrosis, interstitial oedema, haemorrhage, acute inflammation and haemophagocytic syndrome were primarily noted in bone marrow specimens where there was evidence of erythroid hyperplasia. These animals were also more often neutropenic and thrombocytopenic, and had decreased 60 day survival when compared with dogs or cats with non-regenerative anaemia associated with erythroid maturation arrest or PRCA. Therefore, the pathogenesis of the non-regenerative anaemia in non-regenerative IMHA may involve both antibody-mediated destruction of bone marrow precursor cells and pathological events within the bone marrow that result in ineffective erythropoiesis.

  5. Analysis of the energy efficiency of the transport system in Algeria; Analyse de l'efficacite energetique du systeme de transport en Algerie

    Energy Technology Data Exchange (ETDEWEB)

    Hamdani, Sid Ahmed

    2010-09-15

    The objective of this communication is analyze the energy efficiency of the transport system in Algeria and to show the areas of possible rationalization in this sector. Our approach is to analyze the existing configuration of the sector and its impact on energy consumption, by developing a sectional model Bottom Up, where the transport park has been modified by the means used. We have shown that the potential to improve the transport system energy efficiency is important and have recommended some options aimed at the sector organisation and aimed at increasing the relative part of transport systems to make it more energy efficient. [French] L'objectif de cette communication est d'analyser l'efficacite energetique du systeme de transport algerien et de montrer les gisements de rationalisation possibles dans ce secteur. Notre approche consiste a analyser la configuration existante du secteur et son impact sur la consommation d'energie, en elaborant un modele sectoriel Bottom Up, ou le parc de transport a ete desagrege par moyen utilise. Nous avons montre que le potentiel d'amelioration de la performance energetique du systeme de transport est important et avons recommande quelques options ciblant l'organisation du secteur et visant a augmenter la part relative de moyens de transport plus efficace energetiquement.

  6. Linking Drugs to Obscure Illnesses: Lessons from Pure Red Cell Aplasia, Nephrogenic Systemic Fibrosis, and Reye’s Syndrome. A Report From the Southern Network on Adverse Reactions (SONAR)

    OpenAIRE

    Bennett, Charles L.; Starko, Karen M.; Thomsen, Henrik S; Cowper, Shawn; Sartor, Oliver; Macdougall, Iain C.; Qureshi, Zaina P; Bookstaver, P. Brandon; Miller, April D; Norris, LeAnn B.; Xirasagar, Sudha; Trenery, Alyssa; Lopez, Isaac; Kahn, Adam; Murday, Alanna

    2012-01-01

    Identification of serious adverse drug reactions (sADRS) associated with commonly used drugs can elude detection for years. Reye’s syndrome (RS), nephrogenic systemic fibrosis (NSF), and pure red cell aplasia (PRCA) among chronic kidney disease (CKD) patients were recognized in 1951, 2000, and 1998, respectively. Reports associating these syndromes with aspirin, gadodiamide, and epoetin, were published 29, 6, and 4 years later, respectively. We obtained primary information from clinicians who...

  7. Pure red cell aplasia due to parvovirus B19 infection after liver transplantation: A case report and review of the literature

    Institute of Scientific and Technical Information of China (English)

    Ting-Bo Liang; Shu-Sen Zheng; Dong-Lin Li; Jun Yu; Xue-Li Bai; Liang Liang; Shi-Guo Xu; Wei-Lin Wang; Yan Shen; Min Zhang

    2007-01-01

    Pure red cell aplasia (PRCA) due to parvovirus B19(PVB19) infection after solid organ transplantation has been rarely reported and most of the cases were renal transplant recipients. Few have been described after liver transplantation. Moreover, little information on the management of this easily recurring disease is available at present. We describe the first case of a Chinese liver transplant recipient with PVB19-induced PRCA during immunosuppressive therapy. The patient suffered from progressive anemia with the lowest hemoglobin level of 21 g/L. Bone marrow biopsy showed selectively inhibited erythropoiesis with giant pronormoblasts. Detection of PVB19-DNA in serum with quantitative polymerase chain reaction (PCR) revealed a high level of viral load.After 2 courses of intravenous immunoglobulin (IVIG)therapy, bone marrow erythropoiesis recovered with his hemoglobin level increased to 123 g/L. He had a lowlevel PVB19 load for a 5-mo follow-up period without recurrence of PRCA, and finally the virus was cleared.Our case indicates that clearance of PVB19 by IVIG in transplant recipients might be delayed after recovery of anemia.

  8. Rare birth defects associated with Morgagni hernia and segmental aplasia of uterine horn in bitch: Case reportDefeitos congênitos raros em cadela – relato de caso

    Directory of Open Access Journals (Sweden)

    Ricardo Santana de Lima

    2013-09-01

    Full Text Available Birth defects, deformities or abnormalities are terms used to describe developmental defects present at birth, most of which are rare in bitches. We report the case of a six-month old mongrel bitch corpse, which, when subjected to an anatomotopographic study revealed the presence of rare birth defects as Morgagni hernia and segmental aplasia of the right uterine horn with its attachment to the transverses muscle of abdominis. In association with HM, we observed the presence of dextrocardia and a defect of the abdominal wall supraumbilical characteristic of incompletely Pentalogy of Cantrell’s, syndrome so far described only in humans. In association with segmental aplasia of the uterine horn, we observed the ipsilateral presence of the renal hypoplasia and ureteral agenesis. The diagnosis of those abnormalities was based on anatomical findings and confirmed histologically. Despite the rarity and complexity of the abnormalities first described in bitches, the literature suggested that the prognosis may be favorable to the life of the animal. However, early diagnosis is essential to avoid the potential complications of those diseasesDefeitos congênitos, deformidades ou anormalidades são termos usados para descrever defeitos no desenvolvimento presentes ao nascimento. A maioria destes, como a aplasia segmentar uterina, é de ocorrência rara em cadelas. Relata-se o caso de um cadáver de cadela, sem raça definida, de seis meses de idade, que ao ser submetido ao estudo anatomotopográfico revelou a presença de aplasia segmentar uterina (ASU associada à hérnia de Morgagni (HM, agenesia ureteral (AU e hipoplasia renal direita (HR. Além destas anormalidades, foi observada a presença de dextrocardia e de um defeito da parede abdominal supraumbilical, que caracterizam a forma incompleta da pentalogia de Cantrell, só descrita em humanos. O diagnóstico destas anormalidades foi baseado nos achados anatômicos e confirmado histologicamente. A

  9. Hematopoiesis stimulation test by interleukin 1{alpha} gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation; Essais de stimulation de l'hematopoiese par le transfert de gene de l'interleukine-1{alpha} chez le macaque cynomolgus: application a l'aplasie medullaire secondaire a une irradiation accidentelle

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, Th.

    2002-12-15

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  10. Measurement of Anti-Erythropoiesis-Stimulating Agent IgG4 Antibody as an Indicator of Antibody-Mediated Pure Red Cell Aplasia

    Science.gov (United States)

    Weeraratne, Dohan K.; Kuck, Andrew J.; Chirmule, Narendra

    2013-01-01

    Patients treated with erythropoietin-based erythropoiesis-stimulating agents (ESAs) can develop a rare but life-threatening condition called antibody-mediated pure red cell aplasia (amPRCA). The antibody characteristics in a nephrology patient with amPRCA include high antibody concentrations with neutralizing activity and a mixed IgG subclass including anti-ESA IgG4 antibodies. In contrast, anti-ESA IgG4 antibody is generally not detected in baseline samples and antibody-positive non-PRCA patients. Therefore, we validated a highly sensitive immunoassay on the ImmunoCAP 100 instrument to quantitate anti-ESA IgG4 antibodies using a human recombinant anti-epoetin alfa (EPO) IgG4 antibody as a calibrator. The biotinylated ESA was applied to a streptavidin ImmunoCAP, and bound anti-ESA IgG4 antibodies were detected using a β-galactosidase-conjugated mouse anti-human IgG4 antibody. The validated assay was used to detect anti-ESA IgG4 in amPRCA and non-PRCA patients. The immunoassay detected 15 ng/ml of human anti-EPO IgG4 antibody in the presence of a 200 M excess of human anti-ESA IgG1, IgG2, or IgM antibody and tolerated 2 μg/ml of soluble erythropoietin. All patient samples with confirmed amPRCA had measurable anti-ESA IgG4 antibodies. In addition, 94% (17/18) of non-PRCA patient samples were antibody negative or had below 15 ng/ml of anti-ESA IgG4 antibodies. This novel immunoassay can measure low-nanogram quantities of human anti-ESA IgG4 antibodies in the presence of other anti-ESA antibodies. An increased concentration of anti-ESA IgG4 antibody is associated with the development of amPRCA. We propose that the measurement of anti-ESA specific IgG4 antibodies may facilitate early detection of amPRCA in patients receiving all ESAs structurally related to human erythropoietin. PMID:23114696

  11. Efficacité de l’endossement par les célébrité en publicité : Rôle médiateur de la congruence avec l’image de soi

    OpenAIRE

    Jaoued-Abassi, Leyla; Chandon, Jean-Louis

    2006-01-01

    Cet article montre que les caractéristiques de la célébrité (crédibilité et congruence avec la marque) influencent l’efficacité de l’endossement. Il met également en avant le rôle médiateur de la congruence avec l’image de soi ainsi que le rôle modérateur de l’implication dans la catégorie de produit, le contexte de consommation du produit et l’attitude envers la marque antérieure à l’exposition. Les variables dépendantes du modèle sont l’attitude envers l’annonce, l’attitude envers la marque...

  12. Influence de la fréquence et de la période de nourrissage sur la croissance et l'efficacité alimentaire d'un silure africain, Heterobranchus longifilis (Teleostei, Clariidae)

    OpenAIRE

    Kerdchuen, N.; Legendre, Marc

    1991-01-01

    L'influence de la période (jour, nuit) et de la fréquence d'alimentation (1 à 4 repas fractionnés ou alimentation continue) a été étudiée sur la croissance et l'efficacité alimentaire chez un silure africain (#Heterobranchus longifilis$). L'expérience, d'une durée de 56 jours, a été réalisée sur des poissons de 74 g de poids moyen initial. Avec un même taux de rationnement (3% du poids moyen vif/jour), les poissons nourris la nuit ont une croissance significativement plus élevée que ceux nour...

  13. L'efficacité d'usage énergétique : pour une meilleure gestion de l'énergie électrique intégrant l'usager dans les bâtiments

    OpenAIRE

    Chenailler, Hervé

    2012-01-01

    La consommation énergétique, et en particulier électrique, des bâtiments est grandement influencée par le comportement de ses usagers. L'analyse de l'usage électrique au travers d'un retour d'expérience réalisé sur une plateforme bâtiment-test nous a permis d'identifier qu'il pouvait exister différentes formes de satisfactions des usagers remettant en question la notion même d'efficacité énergétique d'un bâtiment. Afin de pouvoir intégrer l'acteur humain dans la conception de systèmes complex...

  14. L'efficacité d'usage énergétique : pour une meilleure gestion de l'énergie électrique intégrant les occupants dans les bâtiments

    OpenAIRE

    Chenailler, Hervé

    2012-01-01

    La consommation énergétique, et en particulier électrique, des bâtiments est grandement influencée par le comportement de ses usagers. L'analyse de l'usage électrique au travers d'un retour d'expérience réalisé sur une plateforme bâtiment-test nous a permis d'identifier qu'il pouvait exister différentes formes de satisfactions des usagers remettant en question la notion même d'efficacité énergétique d'un bâtiment. Afin de pouvoir intégrer l'acteur humain dans la conception de systèmes complex...

  15. Le Sentiment d’Efficacité Professionnelle, un indicateur pour connaître le développement professionnel des « nouveaux » professeurs de l’enseignement agricole français

    OpenAIRE

    Jean-François Marcel

    2011-01-01

    Cet article est structuré autour d’un indicateur visant à appréhender le développement professionnel dans une perspective heuristique. Il s’agit du Sentiment d’Efficacité Professionnelle emprunté à Bandura (2003). Cet indicateur se positionne le long d’un continuum allant de la théorie à l’empirie et en assume la cohérence et la consistance. Ainsi, il s’ancre dans un cadre théorique (le développement professionnel perçu) et, au travers d’un dispositif méthodologique, permet d’accéder à l’empi...

  16. Variabilité génétique de l'efficacité alimentaire en régime alimentaire suboptimal chez le poulet de chair : perspectives pour la sélection

    OpenAIRE

    Mignon-Grasteau, Sandrine; Narcy, Agnès; Tran, Thanh-Son; de Verdal, Hugues; Bastianelli, Denis; Juin, Herve; Carré, Bernard

    2013-01-01

    Le coût de l’aliment représente une part prépondérante des coûts de production du poulet de chair. L’efficacité alimentaire est donc un élément clé de la rentabilité de la production avicole. La sélection génétique des poulets de chair a résulté en une amélioration considérable de l’indice de consommation, en utilisant des régimes alimentaires de bonne qualité. De nos jours, alors que le prix des matières premières de bonne qualité et que la population humaine augmentent, l’intérêt d’une séle...

  17. Castration du porcelet : évaluation de l'efficacité analgésique per-opératoire de l'huile essentielle Mentha arvensis (menthe des champs) par l'analyse des vocalisations

    OpenAIRE

    Zbik, Marion

    2013-01-01

    La castration des porcelets mâles est légalement pratiquée avant l'âge de 7 jours sans analgésie ni anesthésie, Cette castration chirurgicale cause une douleur importante aux porcelets. Dans un contexte où le bien-être animal a une place importante, et où l'engouement pour les "médecines alternatives" prend de l'ampleur, l'objet de notre projet est d'évaluer l'efficacité analgésique de l'huile essentielle de menthe des champs en application topique avant la castration, L'outil choisi pour éva...

  18. « Premier principe : je crois en moi... parce que c’est aussi dans mon intérêt » : une formation pour renforcer les sentiments d’efficacité

    OpenAIRE

    Nota, Laura; Soresi, Salvatore; Ferrari, Lea

    2011-01-01

    La théorie sociale cognitive qui analyse les processus de choix en relation avec les intentions d’avenir met l’accent sur le caractère dynamique du comportement humain et sur le rôle actif que les individus ont sur la détermination de leurs actions. Les croyances d’efficacité jouent à cet égard un rôle important et influencent les processus à l’œuvre dans le choix d’une profession. Permettre aux personnes de mieux contrôler leur propre comportement et les aider à jouer un rôle actif peut auss...

  19. Evaluation à échelle réduite de l'efficacité d'insecticides régulateurs de croissance sur les larves du complexe Simulium damnosum (Diptera : Simuliidae)

    OpenAIRE

    Doannio, J.M.C.; Dossou-Yovo, J.; Duval, Jacques; Hougard, Jean-Marc

    1992-01-01

    L'efficacité de formulations de régulateurs de croissance des insectes a été testée à échelle réduite sur des larves du complexe #Simulium damnosum$ en Côte d'Ivoire. Trois des composés testés appartiennent au groupe des benzoyphényl-urée substitués, inhibiteurs de synthèse de la chitine (OMS 2015 (triflumuron), OMS 3009 (téflubenzuron), OMS 3013 (chlorfluazuron)). Deux autres appartiennent au groupe des analogues synthétiques de l'hormone juvénile (OMS 3007 et OMS 3019). Le dernier est un ph...

  20. Aspergillosis in immunocompromised children acute myeloid leukemia and bone marrow aplasia.: Report of two cases Aspergilose em crianças imunocomprometidas com leucemia mielóide aguda e aplasta de medula óssea: Registro de 2 casos

    Directory of Open Access Journals (Sweden)

    Maria Zilda de Aquino

    1994-10-01

    Full Text Available Two cases of Aspergillosis in immunocompromised children are reported. Both were caused by Aspergillns flavus. Early diagnosis and treatment led to the remission of the process. One patient had acute myeloid leukemia; the fungus was isolated from the blood. The other patient with bone marrow aplasia, presented an invasive aspergillosis of the paranasal sinuses with dissemination of fungal infection; the diagnosis was obtained by histology and culture of biopsied tissue from a palatal ulceration.No presente trabalho são registrados dois casos de aspergilose em crianças imunocomprometidas. O estudo micológico completo identificou Aspergillus flavus como agente dos dois processos. A presença cada vez mais frequente da aspergilose invasiva deve-se ao número crescente de pacientes imunocomprometidos, muitos com hemopatias graves submetidos à quimioterapia. O diagnóstico precoce em um dos casos possibilitou remissão do processo. Tratava-se de paciente com leucemia mielóide aguda, tendo sido isolado o fungo do sangue circulante. O segundo caso evoluiu para óbito, com infecção fúngica generalizada.

  1. Long-term outcome of individuals with pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant epoetin: a follow-up report from the Research on Adverse Drug Events and Reports (RADAR) Project

    Science.gov (United States)

    Bennett, Charles L.; Cournoyer, Denis; Carson, Kenneth R.; Rossert, Jerome; Luminari, Stefano; Evens, Andrew M.; Locatelli, Francesco; Belknap, Steven M.; McKoy, June M.; Lyons, E. Alison; Kim, Benjamin; Sharma, Rishi; Costello, Stacey; Toffelmire, Edwin B.; Wells, George A.; Messner, Hans A.; Yarnold, Paul R.; Trifilio, Steven M.; Raisch, Dennis W.; Kuzel, Timothy M.; Nissenson, Allen; Lim, Lay-Cheng; Tallman, Martin S.; Casadevall, Nicole

    2005-01-01

    Since its introduction in 1988, recombinant human erythropoietin (epoetin) has been standard treatment for patients with anemia due to chronic kidney disease. From 1998 to 2004, nearly 200 epoetin-treated persons with chronic kidney disease developed antibodies to epoetin, resulting in pure red cell aplasia (PRCA). The majority of these patients received Eprex, an epoetin alfa product marketed exclusively outside the United States. Herein, we report on the long-term outcome of these individuals. For 170 chronic kidney disease patients who developed epoetin-associated PRCA and had 3 months or more follow-up information available, case reports from the Food and Drug Administration and epoetin manufacturers were reviewed for information on clinical characteristics of the patients, immunosuppressive treatments, epoetin responsiveness, and hematologic recovery. Overall, 64% of the PRCA patients received immunosuppressive therapy, including 19 who also underwent a renal transplantation. Thirty-seven percent experienced a hematologic recovery, with higher hematologic recovery rates among PRCA patients who received immunosuppressive therapy (57% vs 2%, P < .001). Among 34 patients who received epoetin after the onset of PRCA, 56% regained epoetin responsiveness. The highest rates of epoetin responsiveness were observed among persons whose antierythropoietin antibodies were undetectable when epoetin was administered (89%). Among chronic kidney disease patients with epoetin-associated PRCA, epoetin discontinuation and immunosuppressive therapy or renal transplantation is necessary for hematologic recovery. Reinitiation of epoetin therapy among individuals could be considered if antierythropoietin antibodies are undetectable. PMID:16099877

  2. Effect of ionizing radiation on hematopoietic stem cells and progenitor cells: Role of apoptosis and potential therapeutic significance of anti-apoptotic treatments; Effet des rayonnements ionisants sur les cellules souches et progeniteurs hematopoietiques : place de l'apoptose et interet therapeutique potentiel des traitements antiapoptotiques

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mourcin, F.; Grenier, N.; Mayol, J.F.; Leroux, V. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France); Sotto, J.J. [Inst. Albert Bonniot, La Tronche (France); Herodin, F. [Unite de Radiohematologie experimentale, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    Bone marrow aplasia observed following ionizing radiation exposure (Total Body Irradiation; gamma dose range: 2-10 Gy) is a result, in particular, of the radiation-induced (RI) apoptosis in hematopoietic stem and progenitor cells (HSPC). We have previously shown in a baboon model of mobilized peripheral blood CD34{sup +} cell irradiation in vitro that RI apoptosis in HSPC was an early event, mostly occurring within the first 24 hours, which involves the CD95 Fas pathway. Apoptosis may be significantly reduced with a combination of 4 cytokines (4F): Stem Cell Factor (SCF), FLT-3 Ligand (FL), thrombopoietin (TPO), and interleukin-3 (IL-3), each at 50 ng{center_dot}mL{sup -1} (15% survival versus <3% untreated cells, 24 h post-irradiation at 2.5 Gy). In this study we show that addition of TNF-{alpha}(800 IU/ml) induces an increase in 4F efficacy in terms of cell survival 24 h after incubation (26% survival after 24 h irradiation exposure at 2.5 Gy) and amplification (k) of CD34{sup +} cells after 6 days in a serum free culture medium (SFM) (k{sub CD34{sup +}} = 4.3 and 6.3 respectively for 4F and successive 4F + TNF-{alpha}/4F treatments). In addition, the 4F combination allows culture on pre-established allogenic irradiated stromal cells in vitro at 4 Gy (k{sub CD34{sup +}} = 4.5). Overall this study suggests (i) the potential therapeutic interest for an early administration of anti-apoptotic cytokines with or without hematopoiesis inhibitors (emergency cytokine therapy) and (ii) the feasibility in the accidentally irradiated individual, of autologous cell therapy based on ex vivo expansion in order to perform autograft of residual HSPC collected after the accident. (author)

  3. Efficacité d'un exutoire de dévalaison et d'une barrière acoustique pour les smolts de saumon atlantique (Salmo salar L. à l'aménagement hydroélectrique de St. Cricq sur le gave d'Ossau.

    Directory of Open Access Journals (Sweden)

    TRAVADE F.

    1999-04-01

    Full Text Available Une expérimentation a été conduite en 1996 au niveau de l'aménagement hydroélectrique de St. Cricq (gave d'Ossau dans le but de tester deux dispositifs de dévalaison destinés à éviter le passage dans les turbines des smolts de saumon atlantique (Salmo sala L.. Le premier, localisé au barrage, consiste en une barrière acoustique répulsive destinée à détourner les smolts vers un clapet de décharge. Le champ sonore, généré par 16 émetteurs immergés, est dans la gamme de fréquence 100-600 Hz avec un niveau sonore maximal de 120-130 dB. Le deuxième dispositif, localisé à l'usine, consiste en un exutoire de surface situé en rive, à proximité immédiate de la grille de prise d'eau. L'efficacité des deux dispositifs a été évaluée par marquage-recapture et le comportement des smolts a été suivi par radiotélémétrie. Les passages de smolts par le clapet du barrage varient de 20 % à 60 % ; cette efficacité résulte essentiellement du débit élevé transitant par le clapet. Les tests effectués avec et sans barrière acoustique n'ont mis en évidence aucun effet significatif du champ sonore. L'efficacité de l'exutoire du bassin de mise en charge est d'environ 80 %. La faible largeur de la prise d'eau (11 m, le faible espacement des barreaux de la grille de prise d'eau (2,5 cm, les conditions hydrauliques devant la grille qui guident rapidement les poissons vers l'entrée de l'exutoire, et la configuration de l'entrée de l'exutoire qui crée un écoulement à faible gradient de vitesse peuvent expliquer l'efficacité élevée de ce dispositif.

  4. Le Sentiment d’Efficacité Professionnelle, un indicateur pour connaître le développement professionnel des « nouveaux » professeurs de l’enseignement agricole français

    Directory of Open Access Journals (Sweden)

    Jean-François Marcel

    2011-06-01

    Full Text Available Cet article est structuré autour d’un indicateur visant à appréhender le développement professionnel dans une perspective heuristique. Il s’agit du Sentiment d’Efficacité Professionnelle emprunté à Bandura (2003. Cet indicateur se positionne le long d’un continuum allant de la théorie à l’empirie et en assume la cohérence et la consistance. Ainsi, il s’ancre dans un cadre théorique (le développement professionnel perçu et, au travers d’un dispositif méthodologique, permet d’accéder à l’empirie. L’enquête par questionnaire est conduite auprès d’une population de nouveaux professeurs de l’enseignement agricole français. Elle permet de mettre au jour un panorama du développement professionnel perçu par ces enseignants, d’alimenter une analyse critique de l’indicateur proposé et de dresser quelques perspectives pour les recherches à venir.The article is based on an indicator aiming at understanding teachers’ professional development in a heuristic perspective: professional self efficacy borrowed from Bandura (2003. This indicator is situated in a continuum going from theory to empirical data and maintains both its consistency and substance. It is thus, part of a theoretical framework (perceived professional development and permits, through a methodological process, to reach empirical elements. A survey by questionnaire was carried out among new teachers of French agricultural education. The study brings to light an overview of the professional development perceived by these teachers, it permits to build a critical analysis of the indicator in question and draw up new prospects for future research.

  5. One-Dimensional Modelling of Polymer Flood Performance. Analytical and Graphical Solutions Modélisation de l'efficacité du déplacement unidimensionnel par injection de polymères. Solutions analytiques et graphiques

    Directory of Open Access Journals (Sweden)

    Grattoni C. A.

    2006-11-01

    Full Text Available A graphical method for simulating linear polymer flooding is proposed. The method is based upon the analytical solution of Darcy's law and continuity equation which describe the two-phase, one-dimensional, incompressible flow of oil and polymer solution through the reservoir rock. Continuous polymer injection and polymer slug injection are considered. Several physical mechanisms determining microscopic displacement efficiency are taken into account: resistance factor, residual resistance factor, retention composed by adsorption and mechanical entrapment, and inaccessible pore volume. Other properties are not considered: mixing and dispersion, shear and thermal degradation. This analytical-graphical model closely reproduces linear laboratory oil displacement experiments. Consequently, it can be used by the Field Engineer to rapidly estimate the additional oil recoverable by a linear polymer flood. On propose dans cet article une méthode graphique de simulation de l'injection de polymères dans le cas unidimensionnel. Cette méthode est basée sur la solution analytique de la loi de Darcy et de l'équation de continuité qui décrivent l'écoulement diphasique incompressible unidimen-sionnel d'huile et d'une solution de polymères à travers la roche réservoir. On examine l'injection continue et l'injection de bouchons de polymères. On prend en compte plusieurs mécanismes physiques qui déterminent l'efficacité du déplacement microscopique : facteur de ré-sistance, facteur de résistance résiduel, rétention due à l'adsorption et au piégeage mécanique et, enfin, volume des pores inacessibles. On ne tient pas compte des autres propriétés : mélange et dispersion, dégradation mécanique et thermique. Ce modèle analytique et graphique reproduit très directement les expériences de laboratoire de déplacement d'huile en milieu unidimensionnel. II peut donc être utilisé par l'ingénieur de chantier pour une estimation rapide de l

  6. Clinical importance of digitized chest X-ray for detection of pulmonary infiltrations in bone marrow transplant patients during aplasia; Wertigkeit der digitalen Thoraxaufnahme bei der Detektion von Lungeninfiltraten knochenmarktransplantierten Patienten in der Aplasie

    Energy Technology Data Exchange (ETDEWEB)

    Weber, C.; Maas, R.; Steiner, P.; Kramer, J.; Bumann, D.; Buecheler, E. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Abt. fuer Roentgendiagnostik; Zander, A.R. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Zentrum fuer Knochenmarktransplantation

    1999-10-01

    Purpose: Evaluation of digitized chest X-ray for the detection of pulmonary infiltrations in bone marrow transplant patients during aplasia. Methods: Digitized chest X-rays of 40 patients (21 female, 19 male) with 'Fever of unknown origin' (FUO) were evaluated concerning radiological signs of pulmonary infiltrations and correlated to clinical findings, blood chemistry, microbiology and bronchoscopy. Additionally, an individual risk profile was established. Results: In 11/40 patients pulmonary infiltrations were detected in digitized chest X-rays (group 1). 10/11 developed an infectious pulmonary infiltration. 29/40 patients developed no pulmonary infiltration (group 2). When fever increased for the first time (initial chest X-ray) a sensitivity, specificity, positive and negative predictive value of 46%, 86%, 56%, 81% and for the chest X-rays in process of 61%, 79%, 68% and 73% was found. C-reactive protein and temperature increase occured statistically significantly earlier (p<0.05) in group 1 compared to group 2. The average latency of digital chest X-rays in comparison to c-reactive protein and temperature increase was 6 days. The incidence of risk factors was significantly higher in group 1 in comparison to group 2 (p<0.05). Conclusion: Digitized chest X-rays are not a reliable method for primary detection of pulmonary infiltrations after bone marrow transplantation. Individual risk factors have to be taken into consideration to indicate further diagnostic methods such as computed tomography at an earlier time. (orig.) [German] Ziel: Wertigkeit der digitalen Thoraxaufnahme bei der Detektion pulmonaler Infiltrate bei knochenmarktransplantierten Patienten in der Aplasie. Methoden: Digitale Thoraxaufnahmen von 40 Patienten (21 Frauen, 19 Maenner) in Aplasie mit Fieber unklarer Genese wurden nach Zeichen pulmonaler Infiltrate ausgewertet und mit klinischen, laborchemischen, mikrobiologischen und bronchoskopischen Befunden korreliert. Zusaetzlich wurde ein

  7. Contribution à la statistique des diffusions. Estimation semiparamétrique et efficacité au second ordre.
    Agrégation et réduction de dimension pour le modèle de régression.

    OpenAIRE

    Dalalyan, Arnak S.

    2007-01-01

    Ce texte constitue une synthèse de mes travaux de recherche menés depuis 2000 en statistique mathématique. Ces travaux s'articulent autour de 4 thèmes: la statistique non paramétrique pour les processus de diffusion, efficacité au second ordre pour l'estimation semiparamétrique, agrégation par des poids exponentiels et réduction de dimension pour la régression non paramétrique. Le premier chapitre contient une description générale des résultats obtenus en les replaçant dans un contexte histor...

  8. Influence de l'énergie de surface d'un tambour deshuileur sur son efficacité de relevage Influence of the Surface Energy of a Deoiling Drum on Its Gathering Efficiency

    Directory of Open Access Journals (Sweden)

    Aurelle Y.

    2006-11-01

    Full Text Available Au cours de cette étude est analysée l'influence de l'énergie de surface d'un tambour déshuileur sur son efficacité et sa sélectivité de relevage. Quatre tambours en acier inoxydable, en polychlorure de vinyle, en polypropylène et en dérivé fluorocarboné de tensions critiques de mouillage différentes sont testés comparativement en fonction de l'histoire de leur expositionvis-à-vis de phases hydrocarbure (kérosène et eau. Les essais réalisés montrent que seuls les tambours en dérivé fluorocarboné de très faible tension critique de mouillage s'avèrent intéressants pour des utilisations industrielles. En effet, ils présentent un comportement indépendant de l'histoire de leur exposition ce qui les rend très faciles à utiliser, sans précautions particulières, du fait de leur très grande sélectivité vis-à-vis des hydrocarbures. Par contre, les autres tambours, qui présentent des contributions polaires non négligeables à leur énergie de surface, ont des comportements vis-à-vis des hydrocarbures fonction de l'histoire de leur exposition et ne s'avèrent pas sélectifs vis-à-vis des hydrocarbures à récupérer. The aim of this article is to analyze the influence of the surface energy of a deoiling drum on its gathering efficiency and selectivity. The project consists in testing drums having the same size but made of materials having different surface energies so as to evaluate the influence of this key parameter that had previously been poorly analyzed. Four materials were chosen : stainless steel, polyvinyl chloride, polypropylene, and a fluorocarbon derivative. These materials are representative, a priori, of the behavior of most materials because of the position of their critical wetting tension (gamma c compared to the superficial tension values of water (72 dyn/cm and the hydrocarbon phases to be gathered (25 to 35 dyn/cm (Fig. 1. It should be noted that the fluorocarbon derivative drum tested was patented by

  9. Collection efficiency of charges in ionization chambers in presence of constant or variable radiation intensity; Efficacite de la collection des charges dans les chambres d'ionisation en presence d'une intensite de rayonnement ionisant constante ou variable

    Energy Technology Data Exchange (ETDEWEB)

    Decuyper, J. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1970-07-01

    The theoretical and experimental study of the collection of carriers built up by ionization in standard chambers, is made by varying the value of different acting parameters. In the presence of constant ionization intensity and under a D.C. and A.C. voltage, the effect of geometry, recombination, diffusion and attachment is analyzed. The compensation of thermal neutron D.C. chambers is equally considered. Under a time dependent ionization intensity and D.C. voltage, is then studied the effect of recombination on current response, and on the collection efficiency of all formed charges. (author) [French] L'etude theorique et experimentale de la collection des porteurs crees par ionisation dans les chambres couramment utilisees est entreprise en fonction de la valeur des differents parametres agissants. En presence d'une ionisation constante et sous une tension d'alimentation d'abord continue puis alternative, on analyse l'influence de la geometrie, de la recombinaison, de la diffusion et de l'attachement. La compensation des chambres a courant continu de mesure neutronique est egalement examinee. Ensuite, sous une intensite d'ionisation variable dans le temps et en alimentation continue, on etudie l'effet de la recombinaison sur la reponse en courant et sur l'efficacite de la collection de la charge totale liberee. (auteur)

  10. Evaluation of the Energy Efficiency of a Fleet of Electric Vehicle for Eco-Driving Application Évaluation de l’efficacité énergétique d’une flotte de véhicules électriques dédiée à une application d’éco-conduite

    Directory of Open Access Journals (Sweden)

    Dib W.

    2012-09-01

    Full Text Available In this paper, an approach to evaluate the energy efficiency of an electrical vehicle during a short trip is addressed. This approach provides metrics that can be used to evaluate the potential of improvement achievable via intelligent eco-driving techniques and the performance actually achieved by any of them. It can be the basis for an evaluation of a fleet of vehicles and of a whole city for which an energy efficiency map could be derived, depending for instance of traffic management strategy. Experimental data are provided to illustrate the approach for a fleet of electric vehicles in an urban environment. The methods proposed are intended to be the basis of a driver assistance system oriented to optimal eco-driving. Dans cet article, nous proposons une approche pour évaluer l’efficacité énergétique d’un véhicule électrique lors d’un déplacement urbain. Cette approche fournit des outils permettant d’évaluer le gain énergétique réalisable par l’intermédiaire des techniques intelligentes d’éco-conduite. Cette approche peut être utilisée pour évaluer une flotte de véhicules, ainsi que pour élaborer une cartographie énergétique d’une ville. Des données expérimentales sont fournies pour illustrer cette approche sur une flotte de véhicules électriques dans un environnement urbain. Les méthodes d’éco-conduite proposées sont destinées à constituer la base d’un système d’assistance au conducteur.

  11. Variabilité selon le captureur de l'efficacité de répulsifs à base d'huiles végétales dans la protection individuelle contre les piqûres de Simulium damnosum s. l.

    Directory of Open Access Journals (Sweden)

    Sylla M.

    2002-12-01

    Full Text Available Dans le présent article, nous faisons état de la variabilité selon le captureur de l'efficacité de répulsifs à base d'huiles végétales appliquées sur la peau contre les piqûres de Simulium damnosum s. l. Les expérimentations ont été effectuées en zones de savane (Chaussée-Niaka et de forêt (Soubré de Côte d'Ivoire. Les formulations (lotions, crèmes] testées lors de ces travaux ont été obtenues à partir d'huiles d'amande de palme (Elaeis guineensis, de coco (Cocos nucifera et de gobi (Carapa procera. La technique classique de capture sur homme à l'aide de tubes à hémolyse en matière plastique a été utilisée. Pour chaque journée d'expérimentation, un captureur non traité (jambes non enduites de répulsif servait de témoin. Les résultats indiquent qu'en savane, quels que soient le répulsif et le captureur, la densité simulidienne se situait de 1 à 4, 1 à 6 et de 2 à 10 simulies par homme et par jour lorsque le captureur était respectivement protégé avec le coco, le palmiste et le gobi. Avec les mêmes répulsifs, en zone de forêt, l'agressivité simulidienne variait de 9 à 16, de 2 à 30 et de 8 à 49 piqûres par jour. En comparaison, le témoin recevait de 67 à 90 et de 310 à 533 piqûres par jour, respectivement en zones de savane et de forêt. Malgré les variations importantes dans le nombre de simulies capturées en fonction du captureur choisi, nos résultats montrent que quels que soient le répulsif et l'espèce simulidienne, une protection similaire est conférée à tous les captureurs. Ils indiquent également que le recours à des substances naturelles locales, utilisées comme répulsifs en application dermique, est l'une des meilleures méthodes de protection personnelle contre les simulies.

  12. MASTURBATION ET THERAPEUTIQUE : L'EXEMPLE DU TRAITEMENT DES AUTEURS D'AGRESSIONS A CARACTERE SEXUEL

    OpenAIRE

    Le Bodic, Cédric

    2009-01-01

    Dans cet article, nous proposons de nous attarder sur le passage de la masturbation pathogène à la masturbation comme technique thérapeutique, dans le cadre particulier de l'agression sexuelle. Dans son cours consacré aux anormaux, Foucault renseigne sur la figure du masturbateur et propose, derrière une archéologie de l'anomalie, de concevoir que l'anormal tel qu'il se construit au XIXe siècle, naît de trois figures : le monstre, l'individu à corriger et le masturbateur ou l'enfant masturbat...

  13. Diabete et grossesse: impact de l'inertie medicale et de l'observance therapeutique.

    OpenAIRE

    Pintiaux, Axelle; Chabbert-Buffet, N.; Philips , Jean-Christophe; Scheen, André; Foidart, Jean-Michel

    2010-01-01

    Pregnancy and infant outcomes are related to maternal blood glucose profile. Managing preexisting diabetes and achieving euglycaemia before and during the pregnancy reduce the risk for complications. Screening, diagnosis and treatment of gestational diabetes are important issues from a public health point of view, more particularly because of the progression of this disease due to obesity epidemics among young people. Pregnancy in a diabetic woman is a critical situation where neither clinica...

  14. Energy efficiency: utopia or reality?; Efficacite energetique: utopie ou realite?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2006-04-15

    In its 2006 allocution the world council on the energy WEC, analyzes the role of the energy efficiency in the energy life cycle. In spite of different objectives followed by the developing and developed countries, implement a world energy efficiency economy is a challenge possible by the cooperation.The WEC is an ideal forum for the information and experience exchange. (A.L.B.)

  15. Smart Battery Thermal Management for PHEV Efficiency Une gestion avancée de la thermique de la batterie basse tension de traction pour optimiser l’efficacité d’un véhicule hybride électrique rechargeable

    Directory of Open Access Journals (Sweden)

    Lefebvre L.

    2013-03-01

    la disponibilité d’énergie de traction électrique et la durabilité de la batterie. La conception du système de gestion thermique de la batterie basse tension doit donc prendre en compte les exigences requises de la chaîne de traction et du véhicule, la conception et l’architecture du pack batterie, les contraintes d’environnement, au moindre coût et au moindre poids, etc., tout en optimisant les compromis entre ces paramètres souvent antagonistes. Le processus de conception du thermomanagement de la batterie basse tension de traction fait l’objet de la première partie de cet article. Ce processus sera illustré par deux exemples, l’un mettant en oeuvre l’air en provenance de l’habitacle du véhicule et l’autre, par un refroidissement direct via le circuit de réfrigération du véhicule. Pour une application concrète, le processus de décision doit intégrer l’ensemble des modes de thermomanagement étudiés dans ce contexte et les différents paramètres et exigences pris en compte en tant que données d’entrée. La seconde partie de l’article présente un modèle de simulation thermoélectrique simplifié de la batterie basse tension de traction. Quelques résultats de calculs seront présentés à titre d’exemples dans deux perspectives différentes, d’une part, le dimensionnement thermique du système de thermomanagement, et d’autre part, l’optimisation du bilan énergétique du véhicule. Par ailleurs, ce modèle de simulation simplifié a également permis d’identifier et d’évaluer plusieurs stratégies pertinentes de gestion thermique de la batterie. Ces stratégies visent à améliorer l’efficacité et la performance du véhicule tout en ménageant la durée de vie de la batterie. La troisième partie présente certaines de ces stratégies. Parmi celles-ci, le post-refroidissement et le préconditionnement thermique de la batterie basse tension de traction, en préchauffage par conditions froides et en

  16. Targeted therapies and radiotherapy in lung cancer; Les therapeutiques ciblees en association avec la radiotherapie dans le cancer bronchique

    Energy Technology Data Exchange (ETDEWEB)

    Hennequin, C. [Hopital Saint-Louis (APHP), Serv. de Cancerologie-radiotherapie, 75 - Paris (France); Institut Curie-Orsay, Unite Inserm 612, Centre Universitaire, 91 - Orsay (France)

    2007-01-15

    Targeted therapies are now more often used in lung cancer. Inhibitors of EGFR and of angiogenesis have demonstrated a certain activity in this disease. Some experimental in vitro or in vivo studies are in favour of combined targeted therapies and radiation. For example, additive or supra-additive effects have been shown when inhibitors of the EGFR tyrosine kinase were given with radiation. In advanced lung cancer, the combination of bevacizumab with chemotherapy was demonstrated to produce better survival outcomes. But a high rate of fatal hemoptysis was reported with this drug, particularly for central and squamous tumors. This could be a limitation for its use in combination with radiation. Drugs with multiple targets are becoming available; their association with radiation seems to be promising. (author)

  17. The non-conventional therapeutical indications of I 131; Les indications therapeutiques non conventionnelles de l`I 131

    Energy Technology Data Exchange (ETDEWEB)

    Delisle, M.J.; Schvartz, C.; Maes, B.; Vaudrey, C.; Pochart, J.M. [I.J.G. BP 171, 51056 Reims (France)

    1997-12-31

    In our therapeutic activity the non-conventional indications represent 5-10% relative to the indisputable indications which the hyperthyroidism in the second half of the life and the differential thyroid cancers are. In this paper our experience since 1966 is revised and confronted with the data of international literature. In the last almost 40 years we have treated 178 hyperthyroidism of which 17 were youngsters between 16 and 20 years old, 17 multi-nodular euthyroid goiters (MEG), 85 advanced cardiopathies and 8 Cordarone cardiopathies. The indications are precise: relapses after ATS or surgery in young subjects, counter-indications or surgery refusal for the MEGs and cardiologic indications. The long term surveillance was managed by an adequate code. Immediate morbidity is null. The efficiency is high in the hyperthyroidism treatment. The hypothyroidism is diagnosed and early treated. The reduction of the MEG mass is significant. An objective amelioration of the heart state was obtained (23%). The evaluation of the preventive effect of induced hyperthyroidism by Cordarone is underway. In conclusion, the enlargement of indications concerns mainly the hyperthyroidism in young subjects. In order to avoid carcinogenic risks we excluded the children under 16 years, excepting for special situations. This extension to the procreation age imposes a rigorous application of contraception and radiation protection instructions and needs a prolonged evaluation of results

  18. Investigation of Methane Hydrate Formation in a Recirculating Flow Loop: Modeling of the Kinetics and Tests of Efficiency of Chemical Additives on Hydrate Inhibition Étude de la formation de l'hydrate de méthane dans une conduite de recirculation : modélisation de la cinétique et tests d'efficacité d'additifs chimiques inhibiteurs d'hydrates de gaz

    Directory of Open Access Journals (Sweden)

    Peytavy J. L.

    2006-12-01

    obstruer les lignes de transport et les installations de traitement d'effluents pétroliers. Pour contrôler ces dépôts d'hydrates, on utilise fréquemment, comme inhibiteurs, le méthanol ou les glycols. Aujourd'hui, les équilibres thermodynamiques des hydrates de gaz sont bien connus ; par contre, les cinétiques de formation et de croissance doivent être étudiées afin de mettre en évidence de nouveaux moyens de contrôle grâce à l'étude des mécanismes de formation des hydrates hors équilibre. Le présent travail propose une étude de la cinétique de formation de l'hydrate de méthane dans une boucle de recirculation de laboratoire dans laquelle le mélange liquide, saturé de méthane, circule à une pression maximum de 75 bar. La pression constante au cours des expériences est maintenue par ajout de gaz frais. Dans un premier temps, nous avons étudié les effets de la pression (35-75 bar, de la vitesse d'écoulement du liquide (0,5-3 m/s, de la rampe de refroidissement (2-15°C/h et de la quantité d'hydrocarbure présent dans la charge (0-96 % sur les cinétiques de formation de l'hydrate. Nous proposons ensuite une nouvelle méthode de prédiction, en premier lieu, des conditions thermodynamiques (pression et température correspondant aux valeurs de vitesse de croissance maximum de l'hydrate, puis de ces vitesses de croissance maximum. Nous avons obtenu un bon accord entre valeurs expérimentales et calculées. Enfin, nous avons évalué, en utilisant la procédure expérimentale décrite précédemment, l'efficacité de quelques inhibiteurs cinétiques et tensioactifs mis au point pour éviter, soit la nucléation, soit la croissance des cristaux et l'agglomératon de particules d'hydrates de méthane.

  19. Chirurgie filtrante du glaucome: sécurité et efficacité

    OpenAIRE

    Varga, Zsolt

    2015-01-01

    Le Glaucome est l’une des causes principales de cécité dans le monde. Le nombre de personnes atteintes devrait presque doubler d’ici 25 ans en raison du vieillissement de la population. La chirurgie du glaucome est effectuée pour réduire la pression intraoculaire et arrêter ou ralentir la progression du glaucome avancé non-contrôlé, afin d’éviter la perte de vision et préserver la qualité de vie. De nouvelles interventions chirurgicales ont été développées avec pour objectif de réduire le tau...

  20. Nuclear efficiency against global warming; L'efficacite du nucleaire contre le rechauffement climatique

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2007-09-15

    The nuclear power is capable of contributing in important proportions for the fight against the global warming. With regard to fossil fuels power plants, nuclear power pants allow to avoid every year the release of 2 milliards tons of carbon dioxide that is about 10 % of the world emissions. Energy savings and development of the renewable energies are only a part of the solution, their contribution will be precious but insufficient. It is the nuclear addition with renewable energies that appears as the key solution to slow down the escalation of the greenhouse effect. (N.C.)

  1. La miraculeuse efficacité de la théorie quantique

    CERN Document Server

    Miné, Philippe

    2014-01-01

    Avec les théories de la relativité, la physique quantique est une de ces révolutions conceptuelles qui ont, au cours du XXe siècle, tout changé à notre compréhension de la nature. Si fascinantes que soient ses applications – laser, cryptographie, GPS, ordinateur, imagerie médicale –, la physique quantique fait cependant intervenir des paradoxes déroutants pour notre logique ordinaire. Pénétrer les arcanes du monde quantique, c’est donc aussi accepter d’utiliser le langage des équations, dont les auteurs donnent ici une approche accessible et graduée, n’excédant pas le niveau du premier cycle universitaire et n’oubliant jamais les vertus de l’approche historique. Se révèle ainsi l’univers fabuleux des particules élémentaires, des forces fondamentales de la nature, de la cosmologie et des énigmes de l’espace-temps, thèmes sur lesquels doit s’édifier toute réflexion moderne sur la nature et ses lois. Mais acquérir une certaine familiarité avec le monde quantique ne sig...

  2. The nuclear debate: ethics versus effectiveness; Morale et efficacite dans le debat nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, D

    2009-04-15

    Following some political maneuvering, a new debate on the future of nuclear deterrence is about to resurface. And a first deadline has been set by the need to restore the strategic balance between the United States and Russia before the START Treaty ends on 5 December 2009, as well as by preparation for the next NPT Review Conference. Perception of the main threat has changed, but so have concepts of deterrence. Far from outmoded, deterrence forms part of a broader vision in which realism has the edge over idealism. (author)

  3. Le vaccin antipneumococcique. L'efficacité chez les 55 ans et plus.

    OpenAIRE

    MARCHAND, R

    1993-01-01

    Three recent articles are examined in which research using the double-blind randomised clinical trial, the case control study, and the quasi-cohort study is described. Understanding the advantages and disadvantages of these methods makes it easier to grasp the pneumococcal vaccine controversy and make an informed choice.

  4. Etude in vitro de l'efficacité antifongique de la Piroctone olamine sur Malassezia pachydermatis

    OpenAIRE

    Tané, Elisabeth

    2006-01-01

    Le but de cette étude est d évaluer l'action antifongique de la Piroctone olamine sur Malassezia pachydermatis in vitro. De la Piroctone olamine en poudre, à différentes concentrations allant de 43 à 344 mg/m , est solubilisée puis déposée sur des boîtes de Pétri. Dans un premier temps, l'auteur étudie l'effet préventif antifongique de la Piroctone olamine en répartissant le principe actif sur la gélose de Sabouraud, avant d'ensemencer les levures. Dans un deuxième temps, il applique la Piroc...

  5. Méta-analyse et efficacité des psychothérapies : Faits et fictions

    OpenAIRE

    Zimmermann G.; Pomini V.

    2013-01-01

    In a political environment increasingly concerned with the problem of escalating health care costs, the issue of psychotherapy efficacy evaluation is still debated. Historically, this debate started after Eysenck (1952) published a famous article suggesting that average improvement from pre- to post-therapy has nothing to do with psychotherapy participation, but something that would tend to happen anyway ("spontaneous remission"). Wanting to prove that psychotherapy was effective (Glass, 2000...

  6. Corporate gouvernance: l’efficacité juridique et marketing des codes de conduite

    OpenAIRE

    Sylvie AVIGNON; Dominique BONET FERNANDEZ

    2014-01-01

    Corporate social responsibility and ethics are part of business governance today and represents new ways of market adjustment for companies in quest of legitimacy in an uncertain environment. Tools such as codes of conduct or charts aim at clarifying busi

  7. La bonne ponctuation clarté, précision, efficacité de vos phrases

    CERN Document Server

    Doppagne, A

    1984-01-01

    Une faute d'orthographe peut ne mettre en cause qu'une information plus ou moins conventionnelle ; une faute de ponctuation est presque nécessairement une faute contre la logique, et c'est plus grave.

  8. Le Conseil d'État, frein à l'efficacité administrative ?

    Directory of Open Access Journals (Sweden)

    Odile Daurmont

    2011-09-01

    Full Text Available IntroductionLe lecteur ne trouvera pas ci-après de réponse positive ou négative à la question posée dans l'intitulé. Le but de cette communication n'étant pas de faire l'apologie du Conseil d'État ni l'inverse d'ailleurs mais seulement de fournir des éléments d'information et de réflexion qui permettront au lecteur de se forger une opinion en meilleure connaissance de cause.Il est en effet manifeste que nombreux sont ceux qui ignorent le rôle réel du Conseil d'État ou qui n'ont qu'une informa...

  9. Electricity: France tries to restore efficiency; Electricite: la France tente de retablir l'efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Chauveau, L.; Mulot, R.

    2012-02-15

    While recalling some data regarding the French energy consumption and its costs for the French households, the authors evoke Premio, the oldest experimental smart grid in Europe, and describe its operation. They comment the experience made in Brittany where households are warned when a consumption peak occurs, and will be equipped with devices which will automatically cut the electricity in this situation. They outline the role smart grids could have in energy savings. They also comment the possibilities of the Linky smart meter and the associated network security problems

  10. Les facteurs influençant l'efficacité du marketing relationnel : une approche dyadique

    OpenAIRE

    Lussier, Bruno

    2014-01-01

    A company's success is guaranteed by its relational approach, that is, its ability to establish, develop and maintain new business relationships that are mutually beneficial over time. The seller becomes the centrepiece of the firm, since almost all of his time is spent in contact with customers. This relational approach in a sales context is actually at the heart of successful business. Nevertheless, some businesses have been disappointed with the results of their investment in the relationa...

  11. Energy efficiency: rehabilitation action in public housing project; Efficacite energetique: operation de rehabilitation en HLM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This document presents an operation of rehabilitation in public buildings near Paris (Montreuil). The chosen building is a four floor building built in 1969, showing a favorable solar exposition. Using a bio-climatic and a high environmental quality, the project realized 30% of energy conservation, 30% of water conservation, poor emissivity glass for windows, an outdoor insulation, vitreous balconies and the use of recycled materials. (A.L.B.)

  12. When does action comprehension need motor involvement? Evidence from upper limb aplasia.

    Science.gov (United States)

    Vannuscorps, Gilles; Andres, Michael; Pillon, Agnesa

    2013-01-01

    Motor theories of action comprehension claim that comprehending the meaning of an action performed by a conspecific relies on the perceiver's own motor representation of the same action. According to this view, whether an action belongs to the motor repertoire of the perceiver should impact the ease by which this action is comprehended. We tested this prediction by assessing the ability of an individual (D.C.) born without upper limbs to comprehend actions involving hands (e.g., throwing) or other body parts (e.g., jumping). The tests used a range of different visual stimuli differing in the kind of information provided. The results showed that D.C. was as accurate and fast as control participants in comprehending natural video and photographic presentations of both manual and nonmanual actions, as well as pantomimes. However, he was selectively impaired at identifying point-light animations of manual actions. This impairment was not due to a difficulty in processing kinematic information per se. D.C. was indeed as accurate as control participants in two additional tests requiring a fine-grained analysis of an actor's arm or whole-body movements. These results challenge motor theories of action comprehension by showing that the visual analysis of body shape and motion provides sufficient input for comprehending observed actions. However, when body shape information is sparsely available, motor involvement becomes critical to interpret observed actions. We suggest that, with natural human movement stimuli, motor representations contribute to action comprehension each time visual information is incomplete or ambiguous. PMID:24215324

  13. Medullary aplasia secondary to an irradiation accident: Treatment options and evolution of the concepts

    International Nuclear Information System (INIS)

    Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods. (author)

  14. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees

    Energy Technology Data Exchange (ETDEWEB)

    Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

    2008-01-15

    Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

  15. Indications of hematopoietic stem cell transplantations and therapeutic strategies of accidental irradiations; Indications des greffes de cellules souches hematopoietiques et strategies therapeutiques des irradiations accidentelles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Produced by a group of experts, this document first discusses the issue of accidental irradiations in terms of medical management. They notably outline the peculiar characteristics of these irradiations with respect to therapeutic irradiations. They agreed on general principles regarding casualty sorting criteria and process, and their medical treatment (systematic hematopoiesis stimulation, allogeneic transplantation of hematopoietic stem cells). They discuss some practical aspects of these issues: casualty sorting within a therapeutic perspective (actions to be performed within 48 hours), therapeutic strategies (support therapy, use of cytokines, and therapy by hematopoietic stem cell transplant). They state a set of recommendations regarding the taking into care and diagnosis, therapeutic strategies, research perspectives, and teaching

  16. Therapeutic results and prognostic factors after irradiation of loco-regional prostate cancer. La radiotherapie du cancer de la prostate au stade locoregional: resultats therapeutiques et facteurs pronostiques

    Energy Technology Data Exchange (ETDEWEB)

    Debrigode, C.; Dubois, J.; Hay, H.M.; Astre, C. (CRLC Val d' Aurelle, 34 -Montpellier (France)); Savu, N.M. (Institut d' Oncologie, Bucharest (Romania))

    1994-01-01

    The present study concerns 140 patients with loco-regional prostatic cancer, treated with external beam irradiation at the CRLC Val-d'Aurelle in Montpellier, France, between 1982 and 1988, with a minimum of 54 months follow-up. The local control after radiotherapy is 78.6%, all stages and histological grades combined. The median overall survival is 114 months and the median disease-free survival 59 months. The most frequent modality of treatment failure is metastatic disease, isolated (32.8%) or combined to local relapse (10%). The rate of urinary intolerance symptoms during treatment was 87.1 and 80.6% for the digestive ones. The late urinary complications and sequellae rate was 21.4% for the cystitis-type and 12.9% for post-radiotherapy urethral structures; the latter has imposed in 2/3 of cases one or more trans-urethral resections that never showed pathological signs of recurrence. Digestive complications and sequellae occurred in 31.3% of the patients; in the latter group there were two internal digestive fistulae which needed surgical treatment and three postradiotherapeutic stenosis of the anal canal. The prognostic factors revealed by statistical analysis are clinical stage, pathological grade for overall and disease-free survival, age for overall survival and trans-urethral resection for disease-free survival, the latter being equally a risk factor for cystitis-type complications and urethral structures. (authors). 26 refs., 8 figs., 7 tabs.

  17. Retrospective evaluation of diagnosis and therapy impact of DaTSCAN;Evaluation retrospective de l'impact diagnostique et therapeutique du DaTSCAN

    Energy Technology Data Exchange (ETDEWEB)

    Tabouret-Viaud, C.; Salmon, F.; Perdrisot, R. [CHU de Poitiers, Service de medecine nucleaire, 86 - Poitiers (France); Du Boisgueheneuc, F. [CHU de Poitiers, Service de neurologie, CM2R, 86 - Poitiers (France); Simmat, G. [CHHL Poitiers, service de neurophysiologie clinique, 86 - Poitiers (France); Merlet-Chicoine, I.; Paccalin, M. [CHU de Poitiers, Service de geriatrie, 86 - Poitiers (France); Tournoux-Facon, C. [CHU de Poitiers, centre d' investigation clinique P802, 86 - Poitiers (France)

    2010-05-15

    The objective is to evaluate the clinical impact of the cerebral scintigraphy with DaTSCAN. The evaluation criteria are changing the diagnosis orientation and changing the therapeutic management. Conclusions: In this series of 70 patients, DaTSCAN contributed to a change or a diagnostic accuracy in 66% of patients and a change of in drug therapy in 68% of patients.These results support the use of this expensive drug. (N.C.)

  18. A new therapeutic approach of keloids in Cameroon: post-operative radiotherapy. Une nouvelle approche therapeutique des cheloides au Cameroun: la radiotherapie postoperatoire

    Energy Technology Data Exchange (ETDEWEB)

    Mouele Sone, A.; Ntone Ntone, F.; Ngbangako, M.C. (Hopital General, Douala (Cameroon))

    1993-01-01

    A new therapeutic approach of keloids has been introduced since the establishment of Radiation therapy in Cameroon. Seventeen patients have been treated since April 1989 by surgical excision followed within 24 - 72 hours by external radiotherapy with a total dose of 12 to 20 Gy administered in 3 -5 fractions. All the patients were irradiated with cobalt 60. Fourteen patients were observed 6 months after treatment; 12 of them (85%) were free of the disease. One year after, 6 patients out of 8 no longer presented out of keloids. The secondary effects observed within 2 months after treatment were a mild inflammation of the breast after partial irradiation of the mammary gland and a delayed healing after excision of the keloid with electrical cauterization. All symptoms disappeared without any sequelae.

  19. Immuno-vectorization of radioelements emitters of alpha particles: a new therapy in cancerology; Immunovectorisation de radioelements emetteurs de particules alpha: une nouvelle voie therapeutique en cancerologie

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeois, M

    2007-05-15

    The radio-immunotherapy is an anti cancerous therapy which consists in vectorising with immuno-specific agents very radio toxic radioelements on tumors or in their environment to destroy them. The first part of this report presents the different characteristics of antibodies as well as their means of production under monoclonal shapes specifically steered against a tumoral antigen of interest. The second part of this report replaces the importance of the immunological vectors in the context of the nuclear medicine. It is notably described that the different methods which allow to radio-label the vector, as well as the different ways of optimization which were envisaged to improve the targeting of radioelements on a tumor. These different developments allow to define the potential place of the alpha radio-immunotherapy in treatments and so re-place the interest of the experimental part. If the radio-immunotherapy, using beta emitters isotopes as the {sup 131}iodine or the{sup 90}yttrium, is today current in anti cancerous therapy, it finds limits because of the disintegration characteristics of the isotopes it uses. Indeed, compared with alpha particles, the beta particles deposit less energy by unit of length in the crossed material.The experimental part of this report aims at studying the feasibility of the coupling between an immunological vector and an alpha emitter isotope.The different tests led on the bismuth 213, the bismuth 212, the lead 212 and the astatine 211 demonstrated that the fixation of these radionuclides was possible. This research theme is strengthened by the construction in Nantes of a cyclotron with high energy ( A.R.R.O.N.A.X.) and the optimization of the obtained promising results should allow a therapeutic use in oncology of the alpha radio-immunotherapy. (N.C.)

  20. Fonctionnement et efficacité du comité d’audit : une analyse des interactions entre les participants

    OpenAIRE

    Compernolle, Tiphaine

    2011-01-01

    This research tries to understand audit committee’s working and effectiveness. It aims to open the audit committee black box by analyzing the interactions between participants. The approach is comprehensive, based on analysis of 59 interviews with attendees of 32 CAC 40 companies’ audit committees. Impression management is a central phenomenon in such committee’s meetings. The risk of losing face, which is not felt in the same way by the attendees depending on their status, is a central motiv...

  1. Localisation dans les Réseaux de Capteurs: Protocoles de Communication et Efficacité Energétique

    OpenAIRE

    Tanvir, Sadaf

    2010-01-01

    This thesis deals with localization and energy consumption in Wireless Sensor Networks (WSN). Communication cost is the major source of energy consumption during localization process in WSN. Carrying out WSN localization is a cooperative process throughout the whole network. There are many ways of organizing this cooperation. We propose three such possibilities in the form of our contributed protocols. Cooperation among distributed nodes generates many radio transmissions. Radio broadcasting ...

  2. FEATURES OF THE X-RAY ANATOMICAL CONDITIONS OF THE FOOT AND ANKLE IN CHILDREN WITH FIBULAR APLASIA

    Directory of Open Access Journals (Sweden)

    Дмитрий Степанович Буклаев

    2013-03-01

    Full Text Available The article contains the results of the analysis of radiographs of the foot and ankle in 84 children with malformations of the fibula. We found that infants’ relation to the ankle joint is often normal, as in the sagittal and frontal planes. With increasing age the number of posterior subluxation increases as well as anteriorly, laterally. Also dislocations of the foot were presented. The most significant relationships were violations of the subtalar joint. There were pronation, supinatsion, positions of calcaneus bone and its lateroposition, which was the most frequent cause of valgus deformity. Also we found a violation of the form of the talus such as a flattening of the block, smoothing of the neck. In rare cases of the varus deformity of the foot abnormalities of the tarsal bones were observed.

  3. Allogeneic Th1 Cells Home to Host Bone Marrow and Spleen and Mediate IFNγ-Dependent Aplasia

    OpenAIRE

    Chewning, Joseph H.; Zhang, Weiwei; Randolph, David A.; Swindle, C. Scott; Schoeb, Trenton R.; Weaver, Casey T.

    2013-01-01

    Bone marrow graft failure and poor graft function are frequent complications following hematopoietic stem cell transplantation and result in significant morbidity and mortality. Both conditions are associated with graft versus host disease (GVHD), although the mechanism remains undefined. Here we show in two distinct murine models of GVHD (complete MHC- and class II-disparate) that mimic human peripheral blood stem cell transplantation that Th1 CD4+ cells induce bone marrow failure in allogen...

  4. Gene therapy strategy to reduced bone marrow aplasia: evaluation in cynomolgus macaque exposed to a gamma total body irradiation

    International Nuclear Information System (INIS)

    The aim of this work was to assess whether direct intra-marrow injection of an adeno-viral vector expressing human IL-1α gene stimulates hematopoiesis in healthy non-irradiated and gamma irradiated cynomolgus macaques. In the first hand, we have evaluated the feasibility of this gene therapy strategy in two healthy non-irradiated macaques. In this work, we have observed an increase of neutrophil, monocyte and platelets in the two animals treated with the therapeutic construct. This effect was associated with no abnormal clinical side effect. On the other hand, we have evaluated this strategy in non-human primate exposed to a sublethal gamma irradiation. Two of three animals treated by the therapeutic construct reduced significantly the neutropenia, thrombocytopenia and anemia radio-induced. In conclusion, this gene therapy strategy gave a similar clinical benefit comparatively to systemic administration of huIL-1α but without severe side effect. (author)

  5. Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.

    Directory of Open Access Journals (Sweden)

    Kentaro Suzuki

    Full Text Available Sirenomelia, also known as mermaid syndrome, is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Most affected infants are stillborn, and the few born alive rarely survive beyond the neonatal period. Despite the many clinical studies of sirenomelia in humans, little is known about the pathogenic developmental mechanisms that cause the complex array of phenotypes observed. Here, we provide new evidences that reduced BMP (Bone Morphogenetic Protein signaling disrupts caudal body formation in mice and phenocopies sirenomelia. Bmp4 is strongly expressed in the developing caudal body structures including the peri-cloacal region and hindlimb field. In order to address the function of Bmp4 in caudal body formation, we utilized a conditional Bmp4 mouse allele (Bmp4(flox/flox and the Isl1 (Islet1-Cre mouse line. Isl1-Cre is expressed in the peri-cloacal region and the developing hindimb field. Isl1Cre;Bmp4(flox/flox conditional mutant mice displayed sirenomelia phenotypes including hindlimb fusion and pelvic/urogenital organ dysgenesis. Genetic lineage analyses indicate that Isl1-expressing cells contribute to both the aPCM (anterior Peri-Cloacal Mesenchyme and the hindlimb bud. We show Bmp4 is essential for the aPCM formation independently with Shh signaling. Furthermore, we show Bmp4 is a major BMP ligand for caudal body formation as shown by compound genetic analyses of Bmp4 and Bmp7. Taken together, this study reveals coordinated development of caudal body structures including pelvic/urogenital organs and hindlimb orchestrated by BMP signaling in Isl1-expressing cells. Our study offers new insights into the pathogenesis of sirenomelia.

  6. Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks. From Contamination Analysis to the Collective Whistle-Blowing Process Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des ÉPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    Directory of Open Access Journals (Sweden)

    Alain Garrigou

    2008-05-01

    processus de certification des EPI (équipements de protection individuelle. Sur ces bases, la question des EPI sera alors abordée sous l’angle d’un transfert de technologie entre des milieux industriels et les réalités des situations agricoles. Ceci conduit à un diagnostic très préoccupant en matière d’efficacité réelle des combinaisons. Nous aborderons aussi les questions des responsabilités juridiques soulevées par de tels manquements. Enfin, nous détaillerons le rôle de whistler blower (Vaugan, 1996 que nous avons décidé de jouer ainsi que le processus d’alerte que nous avons construit afin de poser autrement le problème des EPI et intéresser l’ensemble des acteurs.El objetivo de este artículo es presentar los resultados recientes de una investigación/acción en ergotoxicología sobre los riesgos relacionados con el uso de productos fitosanitarios. Esta investigación propone una doble articulación : la primera, entre resultados que emergen de análisis realizados en situaciones de trabajo sobre la contaminación externa de los viticultores y resultados provenientes de tests de laboratorio sobre la permeabilidad de la vestimenta de protección. La segunda articulación trata de la relación entre el conjunto de resultados ya citados y un análisis de los fallos técnicos y organizacionales del diseño y de los procesos de certificación de los EPI (equipos de protección individual. La problemática de los EPI será abordada desde el ángulo de una transferencia de tecnología entre los medios industriales y las realidades de las situaciones agrícolas. Esto conduce a un diagnóstico muy preocupante sobre la eficacia real de las vestimentas de protección. Abordaremos también las preguntas sobre la responsabilidad jurídica que emergen de estas carencias. Finalmente, explicaremos el rol de whistler blower (Vaugan, 1996 que decidimos jugar y el proceso de alerta que construimos para plantear de otra manera el problema de los EPI y hacer

  7. Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des EPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks:From Contamination Analysis to the Collective Whistle-Blowing Process Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    Directory of Open Access Journals (Sweden)

    Alain Garrigou

    2008-05-01

    Full Text Available L’objectif de cet article est de présenter des résultats récents d’une recherche/action en ergotoxicologie concernant les risques liés à l’usage des produits phytosanitaires. Cette recherche propose une double articulation : la première entre des résultats issus d’analyses en situations de travail portant sur la contamination externe des viticulteurs et des résultats issus de tests en laboratoire portant sur la perméation des combinaisons. La seconde articulation concerne le lien entre l’ensemble des résultats cités ci-dessus et une analyse des failles techniques et organisationnelles de la conception et des processus de certification des EPI (équipements de protection individuelle. Sur ces bases, la question des EPI sera alors abordée sous l’angle d’un transfert de technologie entre des milieux industriels et les réalités des situations agricoles. Ceci conduit à un diagnostic très préoccupant en matière d’efficacité réelle des combinaisons. Nous aborderons aussi les questions des responsabilités juridiques soulevées par de tels manquements. Enfin, nous détaillerons le rôle de whistler blower (Vaugan, 1996 que nous avons décidé de jouer ainsi que le processus d’alerte que nous avons construit afin de poser autrement le problème des EPI et intéresser l’ensemble des acteurs.This paper presents the results of an ergotoxicologic study on the effectiveness, in real-life conditions, of the protective suits recommended by preventionists. The arguments presented in the paper are based on the Pestexpo study conducted by Isabelle Baldi (Baldi et al. (2002 and Baldi et al. (2006, which involved analyzing the exposure of vineyard workers to plant protection products by using an ergo-toxicologic approach. The point is to identify different types of exposure by taking into account the characteristics of the actual work (as opposed to what the operators are supposed to be doing as an outcome of personal

  8. New procedures to measure synthase and phosphatase activities of bis-phosphoglycerate mutase. Interest for development of therapeutic drugs; Nouveaux procedes pour mesurer les activites synthase et phosphatase de la bisphosphoglycerate mutase. Interet pour le developpement de drogues therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Ravel, P.; Garel, M.C. [Hopital Henri-Mondor, 94 - Creteil (France); Toullec, D. [Laboratoire Glaxo Wellcome, 91- Les Ulis (France)

    1997-12-31

    In red blood cells, a modulation of the level of the allosteric effector of hemoglobin, 2,3-diphosphoglycerate (2,3-DPG) would have implications in the treatment of ischemia and sickle cell anemia. Its concentrations is determined by the relative activities of the synthase and phosphatase reactions of the multifunctional bis-phosphoglycerate mutase (BPGM). In this report we develop first a more direct synthase assay which uses glyceraldehyde phosphate to suppress the aldolase and triose phosphate isomerase reactions. Secondly we propose a radioactive phosphatase assay coupled to chromatographic separation and identification of the reaction products by paper electrophoresis. Such identification of these products allows us to show that the multifunctional BPGM expresses its mutase instead of its phosphatase activity in conditions of competition between the 3-phosphoglycerate and the 2-phospho-glycolate activator in the phosphatase reaction. These two more precise procedures could be used to study the effects of substrate and cofactor analogues regarding potential therapeutic approaches and could be used for clinical analyses to detect deficiency of BPGM. (author)

  9. A prospective study of the early clinical symptoms following a 2 Gy therapeutic whole-body irradiation; Etude prospective de la symptomatologie clinique precoce apres irradiation corporelle totale therapeutique de 2 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Fizazi, K.; Chaillet, M.P.; Fourquet, A.; Jammet, P.; Cosset, J.M. [Institut Curie, 75 - Paris (France)

    1995-10-01

    Early human tolerance following total body irradiation (TBI) according to the dose received is still poorly known. Thirteen selected patients were prospectively evaluated for clinical side effects during the first 10 hours following a 2 Gy TBI prior to bone marrow transplantation. All of them but one were treated for haematological malignancies and were in clinical remission at the date of TBI. There were 10 males and 3 females, with a median age of 43 y (range 16*61) and a good performance status (WHO 0-1). They received granisetron (3 mg) injected intravenously 1 h before the time of TBI in order to prevent nausea and vomiting. The main symptoms consisted in drowsiness (69%), headache (62%), xerostomia (62%), nausea and vomiting (46%), anorexia (38%), parotid gland pain (23%) and abdominal pain (8%). Their intensity was always moderate, except for 2 patients who experimented severe vomiting. The incidence rate and the time-course of the symptoms of the prodromal phase may proved to be helpful for early clinical evaluation and triage of victims of an accidental irradiation. In particular, absence of fever at the 6{sup th} h after TBI supports the assumption of an estimated exposure dose below 2 Gy. (authors). 23 refs., 2 tabs.

  10. Conformal radiotherapy to 76 Gy in localized prostate cancer. Therapeutic modalities and preliminary results; Radiotherapie conformationnelle a 76 Gy des cancers localises de la prostate. Modalites therapeutiques et resultats preliminaires

    Energy Technology Data Exchange (ETDEWEB)

    Pontvert, D.; Mammar, H. [Institut Curie, Dept. d' Oncologie Radiotherapique, 75 - Paris (France); Flam, T.; Debre, B. [Hopital Cochin-Saint-Vincent-de-Paul, Service d' Urologie, 75 - Paris (France); Thiounn, N. [Hopital Necker-Enfants-Malades, Service d' Urologie, 75 - Paris (France); Gaboriaud, G. [Institut Curie, Service de Physique Medicale, 75 - Paris (France); Jourdan-Da Silvae, N. [Institut Curie, Service de Biostatistique et d' evaluation clinique, 75 - Paris (France); Beuzeboc, P. [Institut Curie, Dept. d' Oncologie Medicale, 75 - Paris (France)

    2008-03-15

    Purpose: to describe therapeutic modalities for localized prostate cancer treated by conformal radiation to 76 Gy with or without androgen ablation. To evaluate the preliminary results in terms of survival, biological control and toxicity. Patients and method: between January 1998 and June 2001, 321 patients with localized prostate cancer were irradiated at Institut Curie. Tumors were stratified into the three Memorial Sloan-Kettering Cancer Center prognostic groups (1998) for analysis: favorable risk group (F.G.) 23%, intermediate risk group (I.G.) 36.5%, unfavorable risk group (U.G.) 40.5%. Androgen deprivation, mainly neo-adjuvant, less or equal to one year was prescribed to 93.8% of patients (72.6% less or equal to six months). Planning target volume prescription doses were: prostate: 76 Gy, seminal vesicles: 56 to 76 Gy, and pelvic lymph nodes: 44 Gy to 16.8% of patients. Results: the five-year actuarial overall survival was 94% (95% I.C.: 90-97%). The median post-therapeutic follow-up was 36 months (nine to 60 months). The 48-month actuarial rates of biochemical control for the three prognostic groups were statistically different according to both the American Society for Therapeutic Radiology and Oncology consensus (A.S.T.R.O. 1997) and the Fox Chase Cancer Center definitions of biochemical failure (F.C.C.C. 2000) with respectively 87 and 94% for F.G., 78 and 84% for I.G., 54 and 58% for U.G. (P < 10-6 and P < 10-8). At time of our analysis, late post-treatment rectal and bladder bleedings were 17,4 and 13,6%, respectively. According to a 1-4 scale adapted from M.D. Anderson Cancer Center criteria: rectal bleedings were grade 1 (9.6%), grade 2 (6.2%) and grade 3 (1.6%). Bladder bleedings were grade 2 (13%) and grade 3 (0.6%). Analysis of rectal bleeding risk factors showed significant correlations with pelvic lymph nodes irradiation for grade 2 and 3, (P = 0.02), and for all grades, a correlation with smaller rectal wall volumes (P = 0.03), and greater percentages of rectal wall irradiated to higher doses: 65, 70, 72 and 75 Gy (P = 0.02, P = 0.01, P = 0.0007 and P 0.003, respectively). Conclusions: these results are comparable to those previously reported with the same follow-up. Impact of dose escalation with short androgen deprivation on local control, survival and complications needs longer follow-up and further analysis. (authors)

  11. What is the future of the children after therapeutic irradiation of their mother during their pregnancy?; Que deviennent les enfants dont les meres ont ete irradiees a visee therapeutique pendant leur grossesse?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2008-12-15

    Abnormalities in children exposed to radiation during gestation occur more specially when the mother irradiation is made between the third and the eleventh week of pregnancy. However a case is reported through a child irradiated in utero and whom development is normal. So, more than a proposition of abortion to the parents it would be convenient to propose a long term surveillance by pediatricians and register these cases in a national data base, this rounding up of knowledge will allow to consolidate the advices that could be given to the parents on taking any precaution in this particularly difficult context. (N.C.)

  12. To understand and manage the digestive radiation injuries: importance of the mucous reaction and new therapy orientations; Apprehender et gerer les lesions radiques digestives: importance de la reaction muqueuse et nouvelles orientations therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Francois, A

    2007-09-15

    Actually the radiotherapy that concerns 50% of anti tumoral treatments is accompanied by side effects. The evolution of this therapy turns towards the limitation of the early effects but also the delayed effects in order to improve the quality of life of patients. The first answer was to reduce the radiation doses and the irradiated volume. Three directions are to be kept in mind concerning the digestive tissues: Fight against the break of the epithelial homeostasis by increasing the pool of cells before irradiation and by facilitating the processes of restoration and epithelial regeneration by the stimulation of the proliferation of the cells of progenitor compartments; Fight against the phenotype changes of the cells, and more globally against the cellular activation and its consequences: activation of the vascular endothelium and the initiation of the inflammatory and thrombosis processes; activation of the vascular smooth muscular cells and stenosis; oxidative stress and tissue hypoxia; recruitment and activation of the mesenchyme cells and matrix unbalance; to consider the global nature of the secondary effects, and become aware that there is, besides the physical twilight connected to the irradiation configuration, a biological twilight, that is to say a potential repercussion of the irradiation effects out of the field, on the global nature of an organ even an organism, and this in the therapy and accident configurations. (N.C.)

  13. Amélioration de l’efficacité de l’absorption du rayonnement solaire photovoltaïque par utilisation des nanostructures.

    OpenAIRE

    TRAORE Soumaïla, Amara

    2014-01-01

    L’absorption complète de la lumière solaire dans le silicium cristallin nécessite une épaisseur de matériau de l’ordre de 500 microns, une large fraction de la lumière est perdue par transmission lorsque l’épaisseur de matériau diminue en deçà de 10 microns. Les cellules photovoltaïques en couches minces (cellules de 2ème génération) tentent de contourner les difficultés rencontrées par cette traditionnelle technologie en minimisant la quantité de matière active semi-conductrice par kWh insta...

  14. Evaluation experimentale de l'efficacite des gants de protection contre les nanoparticules de dioxyde de titane dans des conditions de travail

    Science.gov (United States)

    Vinches, Ludwig

    Manufactured titanium dioxide nanoparticles (nTiO2) enter into the formulation of several commercial products including cosmetics, paints, varnishes or food. An increasing number of people will be exposed to nanoparticles (NP), in particular, scientists during their research and workers in companies. As such, they are an emerging source of hazard. Indeed, an increasing number of studies are warning against their likely harmful effects on health. The International Agency for Research against Cancer has classified nTiO2 as being possibly carcinogenic to humans. Furthermore some studies have shown that the skin is not an impervious membrane to the NP and that NP penetration is possible when the skin is injured by abrasion, after repeated flexions or even intact. Therefore, dermal protection will be necessary in order to thoroughly protect NP users. Based upon the precautionary principle, gloves should be used as protection against chemicals. However, to the best of our knowledge, no study on their resistance towards NP has been conducted. In this study, the performance of protective gloves was evaluated with respect to nTiO2 solutions and powders, under conditions simulating occupational use. Mechanical deformations, simulating those produced by hand flexing, were applied to nitrile and butyl rubber and latex samples that were in contact with nTiO2 in water, in propylene glycol or in powder form. nTiO 2 penetration through the protective gloves was determined after deformations of the materials. Following these results, the physicochemical and mechanical phenomena that facilitate the penetration of nTiO2 were identified and studied. It was shown that mechanical deformations caused both damage to the sample surface but also a change in the degree of crystallinity of the glove material. Strain energy was also measured. It decreased significantly in presence and absence of nTiO2, indicating a weakening of the polymer chains. A qualitative study showed that repetitive deformations also lead to a decrease in the size of the agglomerates that were contained in the nTiO2 powder. Glove materials that were in contact with colloidal solutions produced a swelling phenomenon. Finally, measurements of the elongation of glove samples immersed in colloidal solutions were used to determine diffusion coefficients across the materials. The transport of the nanoparticles was driven by that of the carrier liquid (water or propylene glycol). Given the carrier solutions and nanoparticles could be transported through the gloves, exposure to skin could occur.

  15. Observateur et contrôle optimal : améliorer l'efficacité de la conduite automobile avec Kalman et Pontryagin

    OpenAIRE

    Sebesta, Kenneth

    2010-01-01

    The PhD presents a combined approach to improving individual car efficiency. An optimal observer, the Extended Kalman Filter, is used to create an efficiency model for the car. Particular attention was paid to handling the asynchronous and redundant nature of the measurement data. A low-cost sensor suite developed to measure data is described. This sensor suite was installed on multiple vehicles to good success. It employsan accelerometer, gps, fuel injector timer, and Vss input to measure al...

  16. Etude comparative relative à l’efficacité énergétique de deux appartements situés à Béchar, Algérie

    OpenAIRE

    BENOUDJAFER, I.; Ghomari, F.; Mokhtari, A.

    2012-01-01

    The aim of this paper is the Comparative Study on Energy Efficiency of two apartments which is located in Bechar (Algeria). In this regard, simulations were performed using the software simulation of thermal behavior in dynamic ‘TRNSYS 16’ with the numerical model type 56. This project is the introduction of insulating materials in buildings to improve thermal comfort and reduce energy consumption. Various solutions have been proposed or variants, which can make a relevant choice...

  17. Optimisation de la qualité et de l'efficacité des dispositifs médicaux de perfusion simple et complexe

    OpenAIRE

    Lannoy, Damien

    2010-01-01

    Intravenous infusion, whether used continuously or intermittently, is a common feature in healthcare, although not without risk. Various medical devices can be used to administer the infusion, sometimes simultaneously, of several active substances . These devices, because of their characteristics, may generate more or less significant variations in drug mass flow rate, which is the amount of drug delivered per unit of time to the patient. The first part of this work on these medical devices f...

  18. Validation expérimentale des critères de persuasion interactive : analyse de leur efficacité à inspecter la persuasion dans des interfaces

    OpenAIRE

    Brangier, Eric; Alexandra, Nemery; Séverine, SCHMITT

    2015-01-01

    International audience; The objective of this article is to present a study that has been made about the use of the interactive persuasion criteria grid in order to identify persuasiveelements in the interfaces. Two groups have been created, “criteria” and “control”. Both should identify persuasive elements of two interfaces: social network (Facebook) and e-commerce (Cdiscount). During the second phase of the experiment, the “criteria” group had an access to the grid. 27 participants were rec...

  19. Nouveaux critères pour juger de l'efficacité d'un fourneau à la combustion du charbon de bois

    OpenAIRE

    Ndaysenga, M.; Croiset, G.; Cordier, Y.

    1994-01-01

    New Criteria to Judge Stove Efficiency in the Charcoal Combustion. The water boil test efficiency for choosing the most economic stove in combustion is estimated on the basis of four stoves. In addition to the heating and boiling energy usually considered as selection criterion, other criteria such as the boiling time and the combustion rate have been taken to indicate efficiency. Strangely, it appeared that the stove which maintains water at its boiling point for a long time and has the lowe...

  20. Méthodes d’optimisation dynamique de systèmes à plusieurs états pour l'efficacité énergétique automobile

    OpenAIRE

    Maamria, Djamaleddine

    2015-01-01

    La gestion énergétique (EMS) pour véhicules hybrides a pour objectif de déterminer la répartition de puissance entre les différentes sources d'énergie de manière à minimiser la consommation de carburant et/ou les émissions polluantes. L'objectif de cette thèse est de développer un EMS en prenant en compte des températures internes (la température du moteur et/ou la température du système de post-traitement). Dans une première partie et en utilisant une connaissance préalable du cycle de condu...

  1. Presentation of the national program for the improvement of the energy efficiency; Presentation du programme national d'amelioration de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    This paper is the presentation of the energy mastership national program. It deals with the actions leading to the development of the enterprises and household demand, the increase of the actions in favor of the energy, the actions in the transportation sector, the actions in the habitat domain, the mastership of the energy consumption for the industrial and service sector industries, the renewable energies development, the ADEME devices. (A.L.B.)

  2. Energy efficiency at the St-Guillaume cheese factory, a profitable choice; L'efficacite energetique a la fromagerie St-Guillaume, un choix profitable

    Energy Technology Data Exchange (ETDEWEB)

    Tremblay, P.; La Roche, R. [Fromagerie St-Guillaume, Saint-Guillaume, PQ (Canada)

    2009-12-15

    The Co-op Agrilait de St-Guillaume is located at near Drummondville, Quebec. The facility employs 160 people to produce 3 million kilograms of cheese annually. In addition, 21 million litres of whey are produced. This sub-product of cheese is turned into powder to make ice cream, protein shakes, energy drinks, and feed for animals. The cost of transforming whey had gone up over the last five years, which also cut into the operating budget. Whey transformation also consumed large amounts of well water. In order to address these challenges, the energy consumption of the facility was evaluated in an effort to lower the energy costs by 30 per cent, lower water consumption and reduce water pollution. The study identified and measured the energy consumption for each activity related to the whey transformation process. The equipment and procedures used in the facility were subsequently modernized and the air quality in the facility was also improved. The improvement in whey transformation rendered the facility profitable again. The project was financed by capital loans over a ten year period, and the money saved during the first year was over $400,000. The money saved over the next 10 years will be more than 2 million dollars. 5 figs.

  3. L'ammoniac NH3 une clé pour comprendre l'efficacité des supergranules d'urée en riziculture irriguée

    OpenAIRE

    Gaudin, Rémi

    1988-01-01

    7 International audience Une petite bougie en céramique poreuse placée au contact d'un supergranule d'urée de 2 g et utilisée comme préleveur, a permis de montrer que quatre jours après le placement de l'engrais azoté, il reste dans la solution du sol 180 mg/L d'azote uréique contre 4000 mg/L d'azote ammoniacal. Cette hydrolyse très rapide se traduit par une augmentation du pH qui atteint presque le pKa de l'ammoniaque (9,25). L'analyse de l'évolution de la concentration en azote ammoni...

  4. Paramètres pour une efficacité accrue de la lecture hypertextuelle en langue seconde Paths Towards Efficient Hypertext Reading in a Second Language

    Directory of Open Access Journals (Sweden)

    Linda de Serres

    2004-12-01

    Full Text Available Tant la lecture à l’écran que celle sur papier occupent une place importante dans nos activités quotidiennes. Toutefois, comme praticien, les avons-nous déjà comparées ? Avons-nous tenté de circonscrire en quoi l’une peut différer de l’autre ? Sans prétendre à une quelconque exhaustivité des différences possibles entre ces deux supports de lecture, nous nous sommes prêtée à l’exercice. Il en ressort une vingtaine de différences. De là, nous nous interrogeons à savoir comment le praticien peut aider le lecteur-navigateur en langue seconde à lire plus efficacement à l’écran ? À partir des protocoles oraux de huit étudiants francophones de 1er cycle ayant lu un hypertexte en anglais langue seconde (L2, nous dégagerons des éléments de réponse. Par le biais d’extraits des verbalisations introspectives des participants nous mettrons en évidence des paramètres à considérer dans cette tâche exigeante qu’est la lecture à l’écran en L2. Nous espérons que ces paramètres soutiennent le praticien désireux de poser des choix éclairés dans un cadre où il évolue avec des lecteurs en L2, dans un cadre où en ce début de XXIe siècle, la lecture à l’écran et la L2 font souvent tandem.Both reading on screen and reading on paper are now of great importance in our daily activities. However, as practitioners, have we ever thought of comparing them? In the present article, we will first compare these two types of reading by considering 20 possible differences. This comparison will lead us to a question: how can we help the second language reader to be more efficient when reading on screen? Suggestions will be made based on ideas drawn from introspective verbal protocols collected during an experiment involving eight French-speaking undergraduate students who were met on an individual basis and who were asked to read a hypertext in English. Pragmatic avenues for practitioners will be suggested. At the turn of the twenty-first century, when an increasing number of undergraduate students must cope not only with hypertext reading but also with a second language, being acquainted with ways of helping them is becoming essential.

  5. Energy sources consumption: end uses, efficiency and productivity; La consommation des sources d'energie: utilisations finales, efficacite et productivite

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J.M. [Institut d' Economie et de Politique de l' Energie (CNRS- UPMF), 38 - Grenoble (France)

    2005-07-01

    This document analyzes the impact of the choices made by all actors, from the energy producers to the process and infrastructure designers and the end users, in the evolution of energy consumptions. Some very little improvements made in the energy efficiency of appliances can become equivalent to the production of several oil fields or power plants at the world scale. More efficient energy uses will not replace the additional productions but they must be considered together to be compared. The energy files are first analyzed as a whole in order to show the hidden field of energy choices. In this framework, users, designers and fitters have to face very different choices because they consider efficiency improvements under different aspects: scientifical, technical, economical and social (public information and habits). These differences in efficiency uses have a time and spatial impact on the growth of energy consumption. The economical and social factors influence the collective way to consume energy and are expressed by the energy intensity of the economic activity. The last part of this document analyzes the influence of this notion on the world energy consumption scenarios at the 2050 prospects. (J.S.)

  6. A medium size hotel in Toronto displays the advantages of energy efficiency; Un hotel de taille moyenne de Toronto demontre les avantages de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2000-09-01

    The Four Points Hotel is located in Toronto and possesses 296 rooms. The annual budget devoted to energy costs was 460 500 dollars. In 1998, the hotel management team met with an energy management team to devise an energy efficiency plan. Approximately one year later, renovation and upgrading work began with the help of the Energy Innovators Initiative from the Office of Energy Efficiency, Natural Resources Canada. The electricity bill represented 73 per cent of the annual energy budget of the hotel. Therefore, lighting seemed like a logical starting point. Each of the 2 700 lamps in the building was replaced with energy efficient lighting. Lighting levels were maintained, and were even improved, as was the case in the interior parking garage. The heating boiler was replaced by an energy efficient one, on the advice of the energy efficiency team. Five heating, ventilation, and air conditioning systems located on the roof, were replaced by energy efficient systems which optimized the ventilation in the hotel. Energy costs were down, as well as the maintenance costs, and the reliability was greatly improved. Energy management is centrally controlled by a computer system called LONWorks. The customers have the possibility of setting their room thermostat between 19 and 24 Celsius. The biggest advantage of the system is the wireless communication between the main building and the parking garage. The parking garage therefore benefits from the same control system without the additional costs associated with the installation of cables. At the start, the expected energy savings were 20 per cent. The management team discovered that the energy savings were more in the order of 35 per cent. In other words, it means 653,000 kWh of electricity and 878,530 hours in gas savings. The first seven months after the completion of the work yielded 52,680 dollars in savings. The hotel business represents a sector where energy efficiency yields big savings, in addition to helping the country meet its goals in terms of climate change. Additional information on the Energy Innovators Initiative is available from Natural Resources Canada.

  7. Efficiency of scintigraphy for leakage diagnosis: clinical reports; Efficacite de la scintigraphie dans le diagnostic de breches: illustration a l'aide de cas cliniques

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Ph.; Jeandot, R.; Cazeau, A.L.; Guyot, M.; Basse-Cathalinat, B. [Hopital Pellegrin, 33 - Bordeaux (France)

    2002-09-01

    In many clinical circumstances (cranial traumatisms, renal dialysis, renal graft complications, or reconstructive surgery), leakage diagnosis is often difficult to prove for clinician. In this way, interest of scintigraphic methods is not often well known. Literature review shows many papers concerning leakage diagnosis but essentially in neurology, digestive reconstructions or renal transplantation surgery. Nevertheless, through our own experience, we show particular cases, for example uro-colic fistula, where isotopic method can be of great interest to clarify complex clinical situations. So, close collaboration is necessary between clinician and nuclear medicine who will adapt methodology to diagnose chidden leakage. (authors)

  8. HEPATOSTAT : EVALUATION DE L'EFFICACITE ET LA TOLERANCE DE LA BITHERAPIE CHEZ LES PATIENTS MAROCAINS TRAITES DE L'HEPATITE C

    OpenAIRE

    El Malki, Ghassan; Ahid, Samir

    2013-01-01

    National audience Title: Evaluation of the efficacy and safety of bitherapy on Moroccan patients treated from hepatitis C. Dr ghassan Elmalki 1, Pr Samir Ahid 1, and Pr Yahia Cherrahn1 1 Research Team of Pharmacoepidemiology & Pharmacoeconomics. Laboratory of Pharmacology - Toxicology, Faculty of Medecine and Pharmacy, Rabat, Rabat, Morocco. Background: In Morocco studies estimate a prevalence of HCV to 3,5% for the whole population, and 5% for the age group between 45 and 75 years. Accord...

  9. Neoplasms radiosensitivity: how to increase the efficiency of radiotherapy. Radiosensibilite des tumeurs: comment augmenter l'efficacite de la radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Calais, G. (Hopital Bretonneau, 37 - Tours (FR))

    1991-12-01

    The hypoxia in the neoplasms is a radioresistance factor. This article is about the methods able to reduce the hypoxia in tumors: use of hyperbaric oxygen, radiosensitizers (as metronidazole), hyperthermia and modification of oxygen release in the tissues in modifying the blood flow and in reducing the hemoglobin affinity for oxygen.

  10. Nouveaux critères pour juger de l'efficacité d'un fourneau à la combustion du charbon de bois

    Directory of Open Access Journals (Sweden)

    Ndaysenga, M.

    1994-01-01

    Full Text Available New Criteria to Judge Stove Efficiency in the Charcoal Combustion. The water boil test efficiency for choosing the most economic stove in combustion is estimated on the basis of four stoves. In addition to the heating and boiling energy usually considered as selection criterion, other criteria such as the boiling time and the combustion rate have been taken to indicate efficiency. Strangely, it appeared that the stove which maintains water at its boiling point for a long time and has the lowest combustion rate doesn 't valorize fuel energy efficiently if you only keep to the heating and boiling energy. The cooking test made it possible to explain that apparent contradiction : the fuel energy fraction which doesn't enter in the calculation of the heating and boiling energy isn't really lost. A low combustion rate associated with a long boiling time proved to be the best criteria of choosing the most economic stove in fuel. Therefore, the only water boil test doesn't make it possible to identify the most economically efficient stove. Resorting to the cooking test is compelling.

  11. The fight against the greenhouse effect. Equity and efficiency; La lutte contre l'effet de serre. Equite et efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Vallee, A. [Paris-12 Univ., 94 - Creteil (France)

    2003-07-01

    The author discusses the definition of an equitable division rule of the global effort of greenhouse gases emissions decrease, the research of the economic efficiency, the flexibility mechanisms and the emissions trading. (A.L.B.)

  12. Faut-il réfléchir pour être performant en groupe ?: les conditions de l’efficacité de la réflexivité

    OpenAIRE

    Facchin, Stéphanie; Tschan, Franziska

    2009-01-01

    In this dissertation I concentrate on some of the boundary conditions of reflexivity in teams. Research has shown that reflexivity (collectively reflecting on the teams’ objectives, strategies, and processes and adapting them accordingly) can enhance team performance and innovation. This effect, however, may have boundary conditions. Indeed, prior research has shown that the positive effects of reflexivity were often not straightforward, but depended on other variables. Given the many variabl...

  13. Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection

    Science.gov (United States)

    Sreedharanunni, S; Sachdeva, MUS; Prakash, G; Das, R

    2016-01-01

    The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings. PMID:26515990

  14. Treatment of patients with a congenital transversal vaginal septum or a partial aplasia of the vagina. The vaginal pull-through versus the push-through technique.

    NARCIS (Netherlands)

    Bijsterveldt, C.D. van; Willemsen, W.N.P.

    2009-01-01

    STUDY OBJECTIVE: The aim of this study is to describe the different modalities of congenital obstructing vaginal malformations and the evaluation of techniques to solve the problem. DESIGN: A retrospective study. SETTING: The University Hospital Nijmegen, the Netherlands. PARTICIPANTS: The medical r

  15. Autologous cell therapy as a new approach to treatment of radiation-induced bone marrow aplasia: preliminary study in a baboon model

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Drouet, M. [Radiohematology Unit, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    The sparing of viable hematopoietic stem and progenitor cells located in underexposed bone marrow territories associated with the relative radioresistance of certain stem cell populations is the rationale for autologous cell therapy consisting of ex vivo expansion of residual cells after collection postirradiation. The feasibility of this treatment mainly depends on time constraints and hematopoietic cell threshold. We showed in this study that in the absence of early-acting mobilizing agent administration, subliminar amounts of CD34{sup +} cells can be collected (1 x 10{sup 6} CD34{sup +} cells/100 mL bone marrow or for 1 L apheresis) from 6-Gy {gamma} globally irradiated baboons. Residual CD34{sup +} cells were successfully expanded in serum-free medium in the presence of antiapoptotic cytokine combination (stem cell factor + FLT-3 ligand + thrombopoietin + interleukin 3, 50 ng/mL each, i.e., 4F): K{sub CD34{sup +}} = x2.8 and x13.7 (n=2). Moreover, we demonstrated the short-term neutrophil engraftment potential of a low-size mixed expanded graft (1.5 x 10{sup 6} final CD34{sup +}cells/kg) issued from the coculture of unirradiated (20%) and 2.5-Gy in vitro irradiated (80%) CD34{sup +} cells on an allogeneic stromal cell layer in the presence of 4F. Further preclinical research needs to be performed to clearly establish this therapeutic approach that could be optimized by the early administration of antiapoptotic cytokines. (author)

  16. The study on the preparation of rhIL-6 and its effects on recovery of mice from radiation-induced hematopoietic aplasia

    International Nuclear Information System (INIS)

    The E coil highly expressing rhIL-6 constructed by our department was fermented and rhIL-6 products were extracted and purified. The specific activity of the purified rhIL-6 products reached 4.83 x 108 IU/mg. The rhIL-6 products were used to treat BALB/c mice injured by 60Co irradiation for six days (2 μg/big/each). The results showed that the bleeding time, coagulation time and prothrombin time of the rhIL-6 treatment group were significantly shorter than those of the control group (P<0.01), the platelet count and WBC increased by 130% and 165% in the treatment group as compared with the control, the numbers of CFU-Mix cultured in vitro and CFU-s in spleen were significantly higher than those in the control group (P<0.01). These results suggest that rhIL-6 exerts beneficial effects on the recovery of mice from radiation-induced injuries of hematopoietic stem/progenitor cells, and thus helps recovery from radiation injury of bone marrow and hematopoietic function. (17 refs., 4 figs., 5 tabs.)

  17. Morphological study of bone marrow to assess the effects of lead acetate on haemopoiesis and aplasia and the ameliorating role of Carica papaya extract.

    Science.gov (United States)

    Tham, Ching S; Chakravarthi, Srikumar; Haleagrahara, Nagaraja; DE Alwis, Ranjit

    2013-02-01

    Lead causes damage to the body by inducing oxidative stress. The sites of damage include the bone marrow, where marrow hypoplasia and osteosclerosis may be observed. Leaves of Carica papaya, which have antioxidant and haemopoietic properties, were tested against the effect of lead acetate in experimental rats. The rats were divided into 8 groups; control, lead acetate only, Carica papaya (50 mg and 200 mg), post-treatment with Carica papaya (50 mg and 200 mg) following lead acetate administration and pre-treatment with Carica papaya (50 mg and 200 mg) followed by lead acetate administration. The substances were administered for 14 days. The effects were evaluated by measuring protein carbonyl content (PCC) and glutathione content (GC) in the bone marrow. Histological changes in the bone marrow were also observed. The results showed that Carica papaya induced a significant reduction in the PCC activity and significantly increased the GC in the bone marrow. Carica papaya also improved the histology of the bone marrow compared with that of the lead acetate-treated group. In summary, Carica papaya was effective against the oxidative damage caused by lead acetate in the bone marrow and had a stimulatory effect on haemopoiesis.

  18. Energy efficiency drivers in Europe. Regulations and other instruments open new horizons for energy management in buildings; Batiments intelligents, confort et efficacite energetique active. Leviers d'efficacite energetique en Europe. Les reglementations et autres instruments incitatifs ouvrent de nouveaux horizons pour la gestion de l'energie dans les batiments

    Energy Technology Data Exchange (ETDEWEB)

    Obara, H. [Schneider Electric, 92 - Rueil-Malmaison (France)

    2010-09-15

    Curbing climate change and global warming will be one of the major challenges of the 21. Century.The very survival of our society could be at stake. Greenhouse gases including CO{sub 2} have been identified as the culprits and the vast majority of industrialized countries have agreed to cut emissions drastically over coming decades. Buildings account for nearly 40% of the energy used in most countries and are responsible for a similar level of global CO{sub 2} emissions. Energy efficiency in buildings is therefore one of the keys to reducing green-house emissions. The main driving force to achieve the ambitious goals that have been set for the reduction of greenhouse gases will come from energy efficiency regulations, building codes, standards, labels, certifications, obligations and incentives, all of which have been multiplying steadily over recent decades. International institutions are rolling out energy efficiency directives and standards that set minimum requirements for buildings.They are gradually being taken into account in national regulations and building codes. Today, most energy efficiency regulations concern building design. They hardly touch on Energy Management aspects that can generate major operational gains with relatively low investments and quick payback. Beyond regulations that focus on minimum requirements, environmental performance labels use building rating criteria that can take energy efficiency much further.They offer a practical way of assigning value to energy efficiency and in this way represent powerful market drivers. Moreover, the important benefits of Energy Management can be easily integrated in the rating criteria of these far-reaching schemes. Indeed, through effective building measurement, monitoring and control systems, Energy Management is one of the keys to rapidly reducing carbon emissions and achieving climate change targets. (author)

  19. Application de la resolution de probleme dans une unite de suicidants et suicidaires: premiers resultats aupres de 53 patients hospitalises

    OpenAIRE

    2009-01-01

    Resume La gestion de la crise suicidaire est abordee de plusieurs angles therapeutiques afin de prevenir les recidives. L?accompagnement psychologique des personnes qui percoivent le suicide comme une solution a leur desespoir et a leurs problemes psychosociaux est consideree comme indispensable par les cliniciens. Mais parfois decus de ne pas trouver des reponses rapides a leur detresse, les patients abandonnent souvent leur suivi apres un leger mieux. Nous nous sommes interroges ...

  20. Insight, obsession et verification dans le trouble obsessionnel-compulsif

    OpenAIRE

    Jaafari, N.; Daniel, M.-L.; Lacoste, J.; Bacconnier, M.; Belin, D; Rotge, J.Y.

    2011-01-01

    Resume Introduction ? L?insight a une place centrale dans le trouble obsessionnel compulsif (TOC), il conditionne la prise en charge diagnostique et therapeutique du patient. Cependant, le role de l?insight dans l?emergence des symptomes obsessionnels compulsifs demeure controverse. Dans le but de clarifier le role de l?insight dans le TOC, nous avons evalue la relation entre le degre d?insight et certaines alterations cognitives qui font le lit de l?expression symptomatique. Pour ...

  1. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  2. Cost evaluation of the enslaved to breathing radiotherapy as part of support program to innovative and expensive therapies; Evaluation du cout de la radiotherapie asservie a la respiration dans le cadre d'un programme de soutien aux therapeutiques innovantes et couteuses

    Energy Technology Data Exchange (ETDEWEB)

    Remonnay, R.; Morelle, M.; Carrere, M.O. [Lyon Univ., 69 (France); GATE, CNRS, UMR 5824, 69 - Ecully (France); ENS LSH, 69 - Lyon (France); Centre Leon-Berard, 69 - Lyon (France); Giraud, P. [Hopital Europeen Georges-Pompidou, Faculte Rene-Descartes, Service d' Oncologie Radiotherapie, Paris V, 75 - Paris (France)

    2009-10-15

    This study had for objective to evaluate the consequences of the implementation of the enslaved breathing on the cost of production of radiotherapy, relatively to the conformal radiotherapy without enslaved breathing (witness group) in the bronchopulmonary cancers and the breast cancers. The tariff aspect was studied. The estimation of the complete cost of the treatment enlighten the inadequacy of the pricing for innovation. (N.C.)

  3. FDG PET/CT in initial staging and early response to chemotherapy assessment of paediatric rhabdomyosarcomas; Apport de la TEP/TDM au {sup 18}FDG dans la stadification initiale et l'evaluation precoce de la reponse therapeutique des rhabdomyosarcomes pediatriques

    Energy Technology Data Exchange (ETDEWEB)

    Eugene, T.; Ansquer, C.; Oudoux, A.; Carlier, T.; Kraeber-Bodere, T.; Bodet-Milin, C. [Services de medecine nucleaire, CHU Hotel Dieu, 44 - Nantes (France); Corradini, N.; Thomas, C. [Services d' oncologie pediatrique, CHU Hotel Dieu, 44 - Nantes (France); Dupas, B. [Service de radiologie, CHU Hotel Dieu, 44 - Nantes (France)

    2010-12-15

    Purpose: The objective of this study was to retrospectively evaluate the impact of positron emission tomography/computed tomography (PET/CT) using fluorine-18-fluorodeoxyglucose (FDG), in comparison with conventional imaging modalities (CIM), for initial staging and early therapy assessment in paediatric rhabdomyosarcoma. Patients and methods: Prior to treatment, 18 patients (age range, 9 months to 18 years) with histologically proven rhabdomyosarcoma underwent FDG PET/CT in addition to CIM (magnetic resonance imaging of primary site, whole body CT and bone scintigraphy). After three courses of chemotherapy, 12 patients underwent FDG PET/CT in addition to CIM. RECIST criteria and visual analysis of FDG uptake were used for assessment of response. The standard of reference was determined by an interdisciplinary tumor board based on imaging material, histopathology and follow-up data (median = 5 years). Results: PET/CT sensitivity was superior to CIM's concerning lymph node involvement (100% versus 83%, respectively) and metastases detection (100% versus 50%, respectively). PET/CT results changed therapeutic management in 11% of cases. After three courses of chemotherapy, the rate of complete response was 66% with PET/CT versus 8% with CIM. Five percent of patients relapsed during follow-up (median = 5 years). Conclusion: This study confirms that PET/CT depicts important additional information in initial staging of paediatric rhabdomyosarcomas and suggests a superior prognostic value of PET/CT in early response to chemotherapy assessment. (authors)

  4. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  5. Brain metastases: epidemiological profile and therapeutic results, about a cohort of patients treated in a radiotherapy department in Algiers; Les metastases cerebrales: profil epidemiologique et resultats therapeutiques, a propos d'une serie de patients traites dans un service de radiotherapie a Alger

    Energy Technology Data Exchange (ETDEWEB)

    Chami, S.; Mekki, F. [Service de radiotherapie, hopital d' Alger, Alger (Algeria)

    2010-10-15

    The authors report a retrospective study of the epidemiological profile, clinic characteristics, and mainly palliative therapeutic treatments, more particularly in terms of life quality, and improvement of clinic symptomatology and performance index. This study is based on 38 patients (17 women and 21 men), with a median age of 58.6, and a Karnofsky index greater than 70 per cent. Various data have been collected: brain metastasis number and topography, time interval between cancer diagnosis and metastasis diagnosis, impact on neuro-cognitive function. Survival has been analysed with the Kaplan-Meier method. Short communication

  6. Stratégies basées sur les brevets et efficacité de la R&D lorsque les innovations sont cumulatives et complémentaires

    OpenAIRE

    Ménière, Yann

    2005-01-01

    La théorie économique aborde généralement le brevet comme un droit exclusif temporaire portant sur un produit ou un procédé, et conférant de ce fait un profit de monopole à l'innovateur. Cette approche permet notamment de mettre en évidence le rôle incitatif du brevet, qui permet de rentabiliser à posteriori les investissements nécessaires à l'innovation. Elle ne permet cependant pas de rendre compte correctement de la réalité des brevets dans de nombreux secteurs, où : - un produit donné peu...

  7. Evaluer l'efficacité d'une campagne de valorisation du bénévolat : Les enseignements de deux expériences contrôlées sur le marché du travail

    OpenAIRE

    Brodaty, Thomas; Emond, Céline; L'Horty, Yannick; Du Parquet, Loïc; Petit, Pascale

    2013-01-01

    2011 a consacré l'Année Européenne du Bénévolat et du Volontariat. Au cours de cette année, les associations ont œuvré pour sensibiliser les entreprises aux compétences développées par les jeunes bénévoles et redéployables dans leur activité professionnelle. Cette campagne de sensibilisation a pris deux formes : d'une part la mise en évidence dans le cadre d'entretiens qualitatifs, des compétences redéployables pouvant être développées par les jeunes dans le cadre de leurs activités de bénévo...

  8. La nécessaire évolution des impératifs d'équité et d'efficacité dans la gestion de l'eau potable en Tunisie

    OpenAIRE

    Touzi, Sarra

    2009-01-01

    The water service in Tunisia has been managed for more than forty years by a public company. A social policy, based on a progressive charging system and a national cross-subsidization had accompanied the service development throughout this period. The sector shows currently good performances with access of the entire urban population and about 92% of the rural population to safe water drinking according to 2007 data. It enters thus in a new phase of development. The aim to increase the supply...

  9. Contribution to the study of hybrid ventilation system effectiveness in office and educational buildings; Contribution a l'etude de l'efficacite des systemes de ventilation hybride dans les batiments du secteur tertiaire

    Energy Technology Data Exchange (ETDEWEB)

    Cron, F.

    2004-06-15

    This study is part of the International Energy Agency Annex 35, 'Hybrid Ventilation in New and Retro-fitted Office Buildings', also called the HybVent Project. It presents the numerical analyses of a number of hybrid ventilation systems and their potential for several buildings in relation to local climate characteristics. The first part of this work reviews the state-of-the-art of existing ventilation systems and details the principles, expectations and features of hybrid ventilation systems. This first section also examines some examples of hybrid systems extracted from the collection of Annex 35 case studies. A comprehensive bibliography of numerical tools available for this type of analysis is given in the second section. The numerical models for building simulation and the object-oriented environment used to develop our simulation tool are presented in this section as well. Two single-zone studies undertaken in this project are reported in the third section. The first study concerns an experimental cell simulation. Numerical results are compared to experimental data to validate the use of the simulation tool developed. The second single-zone study predicts the potential of a specific hybrid ventilation system in a typical classroom, given climatic conditions. Finally, the last section presents a more complete study - a multi-zone study of the Tonga school, an Annex 35 case study located in Sweden. Three rooms were modelled initially to compare numerical results to experimental data and then to analyse the performance of the existing hybrid ventilation system and two other systems. This final study was completed for three European cities with very different climates. The overall analysis of the potential of the hybrid ventilation systems considered and the perspective for future work are outlined in the conclusion. (author)

  10. Bird and chiroptera inventories in Quebec : efficiency of a tried and tested method; Les inventaires d'oiseaux et de chiropteres au Quebec : l'efficacite d'une methode eprouvee

    Energy Technology Data Exchange (ETDEWEB)

    Castonguay, M. [Pesca Environnement, Maria, PQ (Canada)

    2007-07-01

    Environmental monitoring at wind turbine arrays is needed before, during and after project development. Pesca Environmental evaluates the impact of proposed wind turbine arrays on birds and chiroptera by examining their migration patterns through visual and auditory observations during the springtime reproductive and nesting season as well as in the autumn. In order to complete a feasibility study, spring migration patterns of birds and chiroptera must be documented and characterized. In addition to building an inventory of birds and chiroptera, Pesca examines bird behaviour and flight patterns and nesting locations. figs.

  11. Efficacité d'une intervention tutorale sur la progression en anglais des étudiants en première année de sciences humaines et sociales

    OpenAIRE

    Entenmann, Frédéric; Cannard, Christine

    2012-01-01

    International audience This exploratory study aims to measure and understand the nature of the impact of proactive in-class tutoring group sessions on the development of first-year Social Sciences students'English skills. Ten tutorials based on a corpus of texts studied in lectures were offered to them between a pretest and a posttest. Even though the results should be interpreted with great care, this paper shows that the students who attended these tutoring sessions obtain better grades ...

  12. Fission product removal by containment spray - influence of the distance between the drops on the aerosol collection efficiency; Influence de la densite spatiale des gouttes d'aspersion sur l'efficacite de collecte des produits de fission

    Energy Technology Data Exchange (ETDEWEB)

    Gauchet, N

    2000-07-01

    This work is within the framework of the studies that are conducted at the IPSN concerning the loss of coolant in a nuclear reactor. During this kind of accident, a spray system in the reactor containment induces the scrubbing of fission products in the atmosphere, and allows the decrease of their concentration in the containment. Our objective is to study the influence of the distance between the drops of their aerosol collection efficiency. This is not taken into account in the existing models. We stimulate the various aerosol collection mechanisms with one free falling drop using computational fluid dynamics codes. The mechanisms are: deposition by brownian diffusion, impaction and interception of the particles by the drop, and collection of particles in the presence of steam condensation at the surface of the drop. These phenomena are studied for drops ranging in diameter from 100 to 700 micrometers, falling in a saturated air-steam mixture whose temperature varies between 20 and 140 degrees Celsius, and total pressure varies between 1 and 5 bars. We validate these models with results available in the literature and with experimental results CARAIDAS. Then we apply these models to the case of three aligned drops, which constitutes a case for which the proximity of the drops has a strong influence on the collection of aerosols. While varying the distance between the drop from 5 to 25 drop diameters, we can highlight the modification of the collection efficiency of each mechanism related to the disturbance of the velocity and concentration fields in the vicinity of the drops. We note that the strongest variations of efficiency observed are in the field of impaction, and that the steam condensation at the surface of the drops limits the decrease. (authors)

  13. Efficacités et fonctions de la convention collective de travail : étude comparative de l'intervention légale en France et en Espagne

    OpenAIRE

    Cialti, Pierre-Henri

    2013-01-01

    Ce travail vise à réaliser une approche globale des systèmes de négociation collective français et espagnol au travers d’une approche comparative. Dans ce cadre, il apparaît que la loi joue, dans les deux pays, un rôle central. L’appréciation de la portée de son intervention doit cependant conduire, de manière préalable, à envisager le cadre constitutionnel dans lequel elle peut intervenir. Une fois cette étape franchie, suivant la distinction classique entre approche dynamique et statique de...

  14. Assessment of ventilation efficiency for the study of indoor air quality; Appreciation de l'efficacite de la ventilation pour l'etude de la qualite de l'air interieur

    Energy Technology Data Exchange (ETDEWEB)

    Akoua, A.A.

    2004-10-15

    An efficient ventilation system provides a good indoor air quality by eliminating air pollutants and ensuring a satisfactory air renewal. Unlike most research works that deal with test cells with controlled boundary conditions, our study focuses on ventilation efficiency in a real environment. In situ experiments are performed and provide the boundary conditions necessary for CFD (Computational Fluid Dynamics) computations. Using CFD for predicting indoor air quality in a real environment is thus analyzed. The influence of permeability on numerical predictions quality is shown. Unfortunately, it is difficult to quantify accurately the air leakages and their airflow rates. Our study proposes a simplified model that includes air infiltration rates in the CFD computations, and that yields satisfactory results. A critical analysis of ventilation efficiency indices is then performed. It is shown that it is currently impossible to evaluate the air change efficiency ( a e ) in an occupied zone. Concerning the air pollutants removal effectiveness, it is shown that the usual index C e is not suited to ventilation systems with variable airflow rates. For such cases, a new formulation of this index is given. The ratio between the airflow rate and the nominal airflow rate of the ventilation system is also taken into consideration. A coupled analysis of this new index and of this airflow rate ratio enables us to assess the air pollutants removal effectiveness while considering the energetic cost of ventilation. We finally show that there is no universal index. The choice of the index depends on the pollutant, on the pollutant concentration, and on the airflow rate. A tool of decision-making aid is thus proposed in order to evaluate the air pollutants removal effectiveness for various ventilation systems. This tool is flexible and rather simple to use. (author)

  15. Les réseaux sur le marché du travail sud-africain. Une efficacité inégale selon le sexe et l'ethnie

    OpenAIRE

    Gaëlle Ferrant

    2012-01-01

    This paper provides evidence that local social interactions within ethnic groups may explain the puzzling variations in labour-market outcomes across individuals. Being surrounded by working peers increases the probability to be employed and wages. This effect differs through a selection effect : gender and ethnic groups who are discriminated against, benefit most from peer effects. The problems of endogeneity and simultaneity of local peer effects are addressed by using data aggregated at th...

  16. Strategy and development means of the energy efficiency and renewable energies sources in France; Strategie et moyens de developpement de l'efficacite energetique et des sources d'energies renouvelables en France

    Energy Technology Data Exchange (ETDEWEB)

    Cochet, Y.

    2000-09-01

    In the framework of the renewable energies development policy and the energy mastership wanted by the Government, a document has been asked by the Prime Minister. It evaluates the development prospects at long and medium dated, of the main chains of renewable energies production taking into account the national developable deposits size, the technologies assessment, the environmental impacts and the competition facing the traditional energies. It evaluates the measures leading to an increasing efficiency. Measures concerning the regulations, the budget, and the fiscality are also discussed. From these analysis, a national strategy for actions in favor the renewable energies, are proposed. (A.L.B.)

  17. Efficacité comparée de deux méthodes de maîtrise de la reproduction de la brebis Djalonké, variété 'Mossi'

    Directory of Open Access Journals (Sweden)

    Boly, H.

    2000-01-01

    Full Text Available Estrous Synchronisation in Djalonke, var. 'Mossi' Ewes : Comparison of Hormonal Treatment and Ram Effect. Zootechnical (ram effect and hormonal (Fluoro Gestone Acetate or FGA, and Pregnant Mare Serum Gonodotropin or PMSG methods on estrous and parturition synchronisation were tested on 24 Djalonke var. 'Mossi' ewes. The use of ram jumping combined with plasma progesterone assay showed that the zootechnical method using male effect provides better estrous synchronisation (4.8 + 2.2 days for estrous delay and better gathering of parturition (within 8 days. The hormonal method by FGA + PMSG provide good estrous synchronisation (3.1 + 20days but lead to a weak lam-bing gathering (within 21 days. After hormonal induction of estrous, a lower fertility was observed and seems to be related to the doses of FGA and PMSG with were relatively high for these small format of Djalonke var. 'Mossi' breed.

  18. Efficacité de la roche phosphatée de Matongo au travers d'un compostage sur une culture de pomme de terre sur un sol acide de Rabiro (Burundi

    Directory of Open Access Journals (Sweden)

    Van den Berghe, C.

    1993-01-01

    Full Text Available Efficiency of phosphatic rock from Matongo applied in the composting process on potatoes on an acid soil of Rabiro. In the frame of the Cooperation between the CVHA (Cultures Vivrieres de Haute Altitute Project and the Program of Fertilisation of the Agro-systems on Altitude (FAVA of the Faculty of Agricultural Sciences in Burundi, the local phosphatic rock from Matongo has been compared to diammonium-phosphate when added in the composting process. The field trials with potatoes have shown that both phosphate sources have the same fertilizing value when the enriched compost was applied at the dose of 20 t/ha. It is very interesting from agricultural and economical viewpoint to use this phosphatic rock in combination with compost.

  19. Efficacité du vétiver (Vetiveria zizanioides) pour limiter la dispersion de trois micropolluants dans les sols cotonniers et maraîchers du Burkina Faso : endosulfan, cuivre et cadmium

    OpenAIRE

    Ondo Zue Abaga, Norbert

    2012-01-01

    Vetiver was chosen to form hedges around the cotton crops and market gardens in Burkina Faso, in order to limit pollutants dispersal towards plants, surface water and groundwater. The influence of vetiver on the fate of two heavy metals (Cu and Cd) and an insecticide (endosulfan) in the soil-water-vetiver system was studied in two representative soils of Burkina Faso, a vertisol and a lixisol. Batch adsorption coefficient measurements, pot and leaching experiments, under phytotronic and outdo...

  20. Optimizing the efficiency of a diesel engine for a hybrid wind-diesel experimental validation; Optimisation de l'efficacite du moteur diesel pour un systeme hybride eolien-diesel-validation experimentale

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, H.; Dimitrova, M. [TechnoCentre Eolien, Murdochville, PQ (Canada); Ilinca, A. [Quebec Univ., Rimouski, PQ (Canada); Perron, J. [Quebec Univ., Chicoutimi, PQ (Canada)

    2010-07-01

    This study examined the feasibility of using a wind-diesel compressed air storage system in large-scale gas turbines at remote sites where a good wind resource is available. Studies have shown that the system can increase the wind energy penetration rate, particularly when combined with a turbo diesel engine. The system increases the power and performance of the diesel engine and reduces fuel consumption and emissions of greenhouse gases greenhouse gases (GHG). This study included a comparison of different technical solutions for the compressed air energy storage system, and described the one that optimized the performance and cost of the overall system. The optimal solution allowed the turbocharger to operate independently of the engine due to the energy provided by the compressed air in the air turbine. Optimization required maximizing the compressor power as an objective function. The energy balance of the engine itself had to be taken into account, along with the turbo charging system. 12 refs., 2 tabs., 16 figs.

  1. Marketing social et efficacité des campagnes de prévention de santé publique : apports et implications des récents modèles de la communication persuasive

    OpenAIRE

    Marchioli, Audrey

    2006-01-01

    National audience Illustrating an example of persuasive communication applied to marketing, the article shows how research in public health communication can help social marketing to change health behaviors and increase campaign's effectiveness. According to a both scientific and operational objective, the article considers, after a presentation of the recent persuasive models, their contributions to social marketing as well as useful implications for practitioners. Illustrant un exempl...

  2. Melanoma vectorized radiotherapy: anti tumoral efficiency of a new marker labelled by iodine 131; Radiotherapie vectorisee du melanome: efficacite antitumorale d'un nouveau vecteur marque par l'Iode 131

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet-Duquennoy, M.; Papon, J.; Miot-Noirault, E.; Madelmont, J.C.; Chezal, J.M.; Moins, N. [EA4231, universite d' Auvergne, Clermont-Ferrand, (France); Mishellany, F.; Cayre, A. [laboratoire d' anatomopathologie, centre Jean-Perrin, Clermont-Ferrand, (France); Maublant, J. [service de medecine nucleaire, centre Jean-Perrin, Clermont-Ferrand, (France); Guerquin-Kern, J.L. [Inserm U759, laboratoire de microscopie ionique, institut Curie, Orsay, (France)

    2009-05-15

    The melanoma is an invasive pathology for which no treatment is efficient on the disseminated form. The works of the Laboratory aim to conceive molecules presenting a specific affinity for the melanoma by targeting the melanin. The aim of this project is to evaluate for the mouse, the anti tumoral effect of vectorized {sup 131}I by the tracer ICF01012 that presents a durable and specific tumor concentration adapted to an application in internal vectorized radiotherapy. Conclusions: A significant anti tumoral effect of the internal vectorized radiotherapy using the compound {sup 131}I-ICF01012 is demonstrated on two models of melanomas whatever their aggressive potential is. This effect is associated to a inhibition of the tumor cells dissemination towards lungs. The optimization of the therapy protocol is running in order to get a maximal therapy efficiency associated to a controlled toxicity of non-targeted pigmented organs. (N.C.)

  3. Une verification de l'efficacite de la methode verbo-tonale: apprentissage du /y/ francais par des americanophones (Testing of the Efficiency of the Verbo-Tonal Method: The learning of the French /y/ by Speakers of American English)

    Science.gov (United States)

    Fort, Paul; And Others

    1976-01-01

    This article describes a study designed to test the basic notions of the verbo-tonal method of error correction in second language learning, a method based on an awareness of the phonological system of the speaker's native language and its influence on the phonological system of the target language. (Text is in French.) (CLK)

  4. L’azathioprine dans les maladies inflammatoires chroniques intestinales : impact de son métabolisme sur l’efficacité et la sécurité thérapeutique

    OpenAIRE

    Dewit, Olivier

    2012-01-01

    Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. TP metabolism is complex and many enzymes are involved. Among them, Thiopurine methyl transferase is the only one routinely measured by pheno- or genotyping. A decreased TPMT activity results in a potential overdosing of TP drugs leadin...

  5. Les conditions d'efficacité et d'inefficacité de l'intégration d'élèves en situation de handicap, à l'école primaire: point de vue d'enseignants

    OpenAIRE

    Michaud, Nadia; Doudin, Pierre-André

    2015-01-01

    L'intégration scolaire est un sujet très sensible auprès des enseignants. En effet, les réticences pour accueillir un élève en situation de handicap dans les classes peuvent être nombreuses. D’un point de vue légal, l’Accord Intercantonal sur la collaboration dans le domaine de la pédagogie spécialisée a vu le jour en janvier 2011. Il incite les cantons à préférer les solutions intégratives aux solutions séparatives. On tend ainsi de plus en plus vers le concept de « l’école pour tous ». La p...

  6. Efficacité de la synchronisation des chaleurs et insémination artificielle chez le bovin Azawak: intérêt du profil de progestérone

    Directory of Open Access Journals (Sweden)

    Marichatou, H.

    2010-01-01

    Full Text Available Efficiency of Estrous Synchronization and Artificial Insemination in Azawak Cows: Interest of the Progesterone Profile. For a few years, the sperm of selected Azawak bull has been used in artificial insemination (AI on the local bovine races of Niger, to improve the potential of production. Two methods of estrous and ovulation synchronization are compared: vaginal spirals PRID (Progesterone Vaginal Intra Device and intra muscular injection of GnRH (Gonadotropin Releasing Hormon. For this purpose, seven and six Azawak Females were successively used by treatment. AI were carried out twice at 56 h and 68 h for the PRID, and 20 h and 44 h for the GnRH, after stop of the treatment. Heats appearance was controlled by direct observation during the 7 days following the end of the treatment. Blood were carried out for ten females (5 of each batch three times per day from J9 to J16, then once daily until J27, and finally at twice-weekly intervals during the 5 weeks which followed, in order to establish a profile of plasmatic progesterone by animal. In addition, a pregnant diagnosis was carried out per transrectal palpation, three months after AI. For each of the two treatments, three females expressed estrus, including two before the first AI, and the third later (1 and 5 days respectively for the PRID and GnRH. The increase of plasmatic progesterone rate of these two cows, occurred in the two days after the first AI, with a pregnant on both for the PRID, and two for GnRH. The three whose heats were not noted, were not pregnant in both cases, and had an increase in the plasmatic progesterone rate 3 and 8 days after the first AI respectively for the PRID and GnRH. In conclusion, we did not observe a difference in the answers of two treatments. Moreover, the females without estrus observed, were showed a normal cycle (by the progesterone profile but with late ovulations that have not allowed fecundation. These results suggest us once more, to make the first IA as of the appearance of heats, and in addition, to inseminate only on heats observed.

  7. Efficacy of ondansetron in the management of radiotherapy induced emesis: a review. Efficacite de l'ondansetron dans les nausees et vomissements radio-induits: revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. (Hopital Henri-Mondor, 94 - Creteil (France)); Paillarse, J.M.; Votan, B. (Laboratoires Glaxo, 75 - Paris (France))

    1994-01-01

    Radiotherapy-induced emesis depends on the site of irradiation, the field size and the dose per fraction and is generally less intense than chemotherapy-induced emesis. Established anti-emetic drugs offer only limited symptom control (50%). Ondansetron, a 5HT[sub 3] receptors antagonist, had proven a complete or a major control efficacy (0-2 emetic episodes) of 68 to 95% in three pilot studies (fractionated, single-dose and total body irradiations). In controlled studies, ondansetron efficacy was significantly higher than placebo, metoclopramide and prochlorperazine. The treatment was well tolerated in the different studies. (authors). 23 refs., 2 figs., 1 tab.

  8. Efficacité de la technique d'induction florale d'Ananas comosus (L. Merr. au moyen de charbon actif enrichi à l'éthylène (TIFBio

    Directory of Open Access Journals (Sweden)

    Lebeau F.

    2009-01-01

    Full Text Available Efficiency of the Ananas comosus (L. Merr. flower induction treatment based on ethylene enriched activated carbon (TIFBio. Pineapple is an important export crop for tropical countries. The flower induction treatments are essential to the pineapple production for economical and social reasons. For conventional agriculture, many chemicals are available but for organic farming ethylene is the only allowed product. A new flower induction method suited to small organic growers has been developed by the Pesticides Initiative Programme of the Coleacp funded by the European Development Fund. The trials conducted proved that the method reaches more than 80% efficiency at 10 weeks for the different application methods evaluated. The wet application trials show a doses response effect as well as effect of the application replication at 2 days interval. The flowering rate culminates at 100% after 8 weeks for the best results, obtained with the wet treatment at 250 mg per plant applied two times at 2 days interval. The different dry treatments tested gave all 85 – 90% flowering rates at 10 weeks, suggesting the presence of an undetermined limitation factor in the conditions prevailing for the trial. The time of application during the day shows no significant effect. It is concluded that the growers can use the TIFBio technique for production control. It is recommended to evaluate the most suited application technique according to their particular case as environmental effect can affect the efficiency.

  9. L'efficacité énergétique des protocoles de transport fiables pour les réseaux sans fil à faible consommation d'énergie

    OpenAIRE

    Ayadi, Ahmed

    2012-01-01

    Low power and Lossy Networks (LLNs) such as wireless sensor networks are currently used in many important applications fields such as remote environment monitoring and target tracking. This deployment has been enabled by the availability, especially in recent years, of embedded micro-controller devices that are smaller and cheaper. These devices are equipped with wireless interfaces, with which they can communicate with each other to form a network. In this thesis we focus on studying the ene...

  10. Efficacité de la synchronisation des chaleurs et insémination artificielle chez le bovin Azawak: intérêt du profil de progestérone

    OpenAIRE

    H. Marichatou; Issa, M.; Hamadou, I.; Assane, M; Semita, C.

    2010-01-01

    Efficiency of Estrous Synchronization and Artificial Insemination in Azawak Cows: Interest of the Progesterone Profile. For a few years, the sperm of selected Azawak bull has been used in artificial insemination (AI) on the local bovine races of Niger, to improve the potential of production. Two methods of estrous and ovulation synchronization are compared: vaginal spirals PRID (Progesterone Vaginal Intra Device) and intra muscular injection of GnRH (Gonadotropin Releasing Hormon). For this p...

  11. Apport des techniques électrochimiques pour l'amélioration de l'estimation de l'efficacité de la protection cathodique des canalisations enterrées

    OpenAIRE

    Barbalat, Maud

    2012-01-01

    Buried gas transmission lines are protected against external corrosion by organic coatings. Cathodic protection (CP) is designed and operated with the aim to mitigate corrosion where coating is faulty. The EN 12954: 2001 standard specifies reference values of the protection potentials according to soil conditions. However some kind of soils, like silt and clay with high resistivity, are not considered by this standard. Moreover, it is necessary to estimate the residual dissolution rate of the...

  12. Etude des facteurs contrôlant l'efficacité de la sélection génomique chez le palmier à huile (Elaeis guineensis Jacq.)

    OpenAIRE

    Cros, David

    2014-01-01

    La production agricole doit augmenter à un rythme jamais atteint pour faire face à la forte hausse attendue de la demande alimentaire. La sélection génomique (SG) pourrait y contribuer en donnant la possibilité de sélectionner des individus uniquement sur leur génotype, rendant ainsi l’amélioration génétique des rendements plus efficace. L’amélioration actuelle de la production du palmier à huile, première plante oléagineuse au monde, se fait par sélection récurrente réciproque pour produire ...

  13. Effet du mode de conservation de l'huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L. Walp. au Niger

    Directory of Open Access Journals (Sweden)

    Abdoul Habou, Z.

    2014-01-01

    Full Text Available Influence of the Conservation Mode of Jatropha curcas L. oil on its Efficacy in the Control of Major Insect Pests of Cowpea (Vigna unguiculata (L. Walp in Niger. Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to light and the other kept in the dark. The insecticidal efficacy was evaluated in a field with three concentrations (5, 10 and 15% trial on the main pests of Cowpea (Vigna unguiculata (L. Walp and in a laboratory test on Megalurothrips sjostedti Trybon (Thysanoptera: Thripidae with different concentrations of crude oil (50; 100; 150 and 200 µl. No difference in insecticidal effect was found between the two modes of oil conservation, both in the laboratory and in the field. In the field, regardless of the mode of conservation, the concentrations of 10% of J. curcas oil enables a reduction of over than 80% of thrips, aphids, and bugs compared to the control. Its increased seeds yield more than 50%. The concentration of 15% gives an insecticidal effect comparable to that of the reference treatment (deltaméthrine but induces phytotoxicity symptoms on the leaves of Cowpea.

  14. Energy efficiency: EDF Optimal Solutions improves the l'Oreal firm of Vichy; Efficacite energetique: EDF Optimal Solutions ameliore l'usine l'Oreal de Vichy

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2011-09-15

    The l'Oreal CAP site has inaugurated its energetic eco-efficiency installations realized by EDF Optimal Solutions. This solution combines several techniques and makes possible to halve its yearly CO{sub 2} releases. (O.M.)

  15. Place of imaging in the evaluation of treatment response in breast cancer;Place de l'imagerie dans l'evaluation de l'efficacite des traitements dans le cancer du sein

    Energy Technology Data Exchange (ETDEWEB)

    Brunotte, F.; Berriolo-Riedinger, A.; Cochet, A.; Toubeau, M.; Dygai-Cochet, I.; Riedinger, J.M. [Centre Georges-Francois-Leclerc, Service de medecine nucleaire, 21 - Dijon (France); Brunotte, F.; Cochet, A. [Universite de Bourgogne, UMR CNRS 5158, laboratoire electronique, informatique et image, 21 - Dijon (France)

    2010-01-15

    This paper describes, from the current literature, the role of various imaging methods to assess the response to therapy in breast cancer. Two different clinical situations are considered: neo-adjuvant chemotherapy of locally advanced breast cancer and the metastatic breast cancer. Significant clinical data are available for three criteria: the volume of the tumour, the uptake of fluorodeoxyglucose using PET and the perfusion of the tumor evaluated either by dynamic contrast-enhanced magnetic resonance imaging (D.C.E.-MRI) or by PET using {sup 15}O water. {sup 18}F F.D.G. PET allows prediction of the response after one or two cycles of neo-adjuvant chemotherapy. New approaches will offer opportunities to refine the role of imaging in monitoring the response to chemotherapy. PET using thymidine as bio marker is promising in assessing the tissular proliferation. Estrogen analogs could be used to predict hormonally responsive breast cancer. Many other approaches, although less developed, might offer new insights in the response to therapy of breast cancer like magnetic resonance spectroscopy or optical imaging of hemoglobin oxygenation. Imaging also offers potential of monitoring the down-regulation of specialized receptors of the cell membrane in response to treatment: the most studied receptor in preclinical model has been the human epidermal growth factor receptor type 2 (HER2). Integrin, a family of cell adhesion receptor, is also an important target for imaging. Apoptosis, multidrug resistance and hypoxia can also be studied using appropriate bio markers. To allow reliable multicenter trials of new drugs, these different imaging approaches still require an improved standardization of image acquisition and processing. (authors)

  16. Réponses agro-physiologiques et efficacité d'utilisation de l'eau chez le maïs (Zea mays L. - cv. Synthetic-C soumis au déficit hydrique

    Directory of Open Access Journals (Sweden)

    Diouf, M.

    2001-01-01

    Full Text Available Agrophysiological Responses and Water Use Efficiency of Maize (Zea mays L. - cv. Synthetic-C in Water Deficit Conditions. Senegal is known to have very tow rainfall with high probability of drought occurring du ring crop development. The study on the growth of maize under water deficit conditions aimed at characterising its agro-physiological responses and the evaluation of its water use efficiency (WUE. A water deficit was applied respectively during the vegetative phase (T1, at flowering start (T3 and both during the vegetative phase and at flowering start (T2 with a period of rewatering between these two phases. For the control (TO water was applied by irrigation to maintain optimal water conditions for growth. The amount of water to complete (in low rainfall conditions during the cycle was determined by measuring "bac" evapotranspiration and using crop coefficient (Kc for maize during the different phases. The results show that Synthetic-C variety was sensitive to water deficit during the flowering phase. Actually, the relative water content (RWC, leaf water potential and crop water stress index (CWSI were less sensitive to water deficit during the flowering phase than during the vegetative phase. These parameters showed a higher rate of decrease during the vegetative phase. On the other hand, gazeous exchanges [stomatal conductance (Gs and transpiration (Tr] were found to be more sensitive to water deficit during the reproductive stage. Moreover, significantly low grain yield and WUE were observed during this phase of development. However, on the basis of physiological parameters and productivity, Synthetic-C showed a good capacity to resume its physiological activities after rewatering during the vegetative phase, similar to a good plasticity of the control.

  17. Evaluation de l’efficacité d’un module d’enseignement à distance centré sur l’analyse de tâche et l’émission de feed-back

    OpenAIRE

    Lenzen, Benoît; Gustin, Frédéric; Cloes, Marc

    2006-01-01

    L’importance du feedback dans la relation pédagogique d’enseignement a été mise en évidence dans de nombreuses recherches de type « processus-produit » et les mécanismes relatifs à son émission ont par ailleurs été bien définis. La question qui se pose est la suivante : Comment intervenir dans la formation initiale des enseignants en éducation physique et des entraîneurs afin de développer chez eux l’aptitude à corriger les performances motrices des apprenants ? Peer reviewed...

  18. After Kyoto: equity stakes and efficiency in the negotiation on the climatic change; Au-dela de Kyoto: enjeux d'equite et d'efficacite dans la negociation sur le changement climatique

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, O.; Criqui, P.; Viguier, L. [Institut d' Economie et de Politique de l' Energie - IEPE-CNRS/ Universite Pierre Mendes-France, 38 - Grenoble (France); Trommetter, M. [Institut National de Recherches Agronomiques (INRA), 38 - Grenoble (France)

    2000-07-01

    The first difficulty to get over in the international negotiation on the climatic change, has been and still remain the distribution of the efforts and the research of the equity in the objective determination. This paper aims to show that facing the different interests of each countries, a single rule of differentiation is not possible. The first part is a review of the different charts of the objectives differentiation discussed or proposed in the international negotiation process on the greenhouse effect. It aims to find a bond between the the charts and the equity. The second part proposes the quantification of a scenario of the emission licenses attribution for 2030 for all the world countries. (A.L.B.)

  19. Efficacité en pépinière forestière d'un inoculum de champignon ectomycorhizien produit en fermenteur et inclus dans une matrice de polymères

    OpenAIRE

    Le Tacon, François

    1983-01-01

    Pure culture inocula of ectomycorrhizal fungi are usually produced on a vermiculite peat mixture. They can also be prepared by cultivating the fungus in a fermentor and entrapping it in a polymeric gel as proposed by DOMMERGUES et al. (1979) for bacteria and Jung et al. (1981) for different microorganisms. We have prepared different types of inoculum of Hebeloma cylindrosporum as follows : - non washed peat vermiculite inoculum ; - washed peat vermiculite inoculum ; - pellets of myce...

  20. Radio active's risk assessment and management following the death of a patient who received a therapeutic dose of iodine-131 as part of a treatment by radioimmunotherapy; Evaluation et gestion du risque radioactif suite au deces d'un patient ayant recu une dose therapeutique d'iode-131 dans le cadre d'un traitement en radiotherapie metabolique

    Energy Technology Data Exchange (ETDEWEB)

    Djoumessi, C.F.; Prunier, C.; Baulieu, J.L.; Besnard, J.C. [CHU de Tours, Service de Medecine Nucleaire, 37 - Tours (France); Djoumessi, C.F.; Bramoulle, C. [CHRU de Tours, Unite de Radiophysique, Clinique d' Oncologie et de Radiotherapie, 37 - Tours (France)

    2009-07-15

    A patient treated with meta-iodobenzylguanidine (Mibg) marked with iodine-131 for malignant pheochromocytoma died three hours after injection. To minimize radioactive risks, the decision to keep the remains for sixteen days was taken. This paper presents the levels of exposure of different persons involved in the care of the patient since his hospitalization until his funeral and the measures taken to prevent radioactive spread and contamination. (authors)

  1. CONGENITAL ABSENCE OF THE VAGINA - RESULTS OF CONSERVATIVE TREATMENT

    NARCIS (Netherlands)

    LAPPOHN, RE

    1995-01-01

    Objective: To assess the efficacy of a combination of Frank's mold therapy with intercourse as a treatment for congenital vaginal aplasia. Study design: From 1973-1993, thirty-three patients with congenital aplasia of vagina and uterus were seen by one gynecologist. Patients with a partner were inst

  2. L'évaluation peut-elle être un outil de la gouvernance territoriale ?

    OpenAIRE

    Méasson, Ludovic

    2008-01-01

    National audience Ce texte discute de l'intérêt et des limites de la manière dont l'évaluation des politiques publiques aborde actuellement les politiques territoriales. Il montre comment l'évaluation peut dans certains cas être facteur d'incertitude pour les élus, plus qu'un outil de management de celle-ci. Il propose enfin de distinguer deux formes d'efficacité - l'efficacité des politiques et l'efficacité politique - dont l'évaluation pourrait accompagner la co-construction que l'on app...

  3. Energie-Cites opinion on the directive project of CHP. To meet urban energy requirements with optimal energy efficiency and production closer to residents; Avis d'Energie-Cites sur le project de directive cogeneration. Satisfaire les besoins energetiques urbains avec la meilleure efficacite energetique et une production plus proche des habitants

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-01-01

    The Directive on ''the promotion of cogeneration based on a useful heat demand in the internal energy market'' should be adopted very soon. The initial aim of the Directive is to strengthen existing measures to promote CHP in line with the Community target of doubling the share of CHP in EU electricity generation from 9% in 1994 to 18% by 2010. But no target has been mentioned. Energie-Cites states, in this document, its opinion of this draft proposal. Cogeneration is a well-tried and proven technology which has achieved tangible results and is one of the more efficient ways for the EU to fulfill the commitments it made under the Kyoto Protocol. (A.L.B.)

  4. Régime alimentaire et déplacements des macaques à queue de cochon (Macaca leonina) : impact sur leur efficacité dans la dispersion des graines et sur leur contribution écologique dans une forêt tropicale du parc national de Khao Yai, Thaïlande

    OpenAIRE

    Albert, Aurélie

    2012-01-01

    Southeast Asia experiences an exceptional loss of natural habitat due to a deforestation rate that strongly increased during the last decades. The first consequence is the loss of many animal and plant species, threatened by their habitat degradation and by the loss of interactions necessary to the survival of the whole ecosystem. Large mammals and birds populations, the principal dispersal agent of some plant species, already collapsed massively due to hunting and habitat fragmentation and n...

  5. Banques et transmission monétaire dans l'UEMOA : effets des bilans bancaires, de la concentration bancaire et de l'excès de liquidité bancaire sur l'efficacité de la politique monétaire de la BCEAO

    OpenAIRE

    Ouédraogo, Seydou,

    2011-01-01

    This thesis examines the double underperformance of financial liberalization policies in the WAEMU : the low bank credit and ineffectiveness of the monetary policy. Precisely it studies the impact of bank resilience on bank lending and on the monetary transmission.The thesis provides the following results : 1/ bank balance sheets alter the monetary transmission, small banks, less capitalized and less liquid banks, transmit more fully the monetary shocks 2/ bank concentration weakens the bank ...

  6. Meels: municipalities and energy efficiency in a liberalized system. Guidelines for municipalities: adapting to new roles in a liberalized market; Meels: les municipalites et l'efficacite energetique dans un systeme liberalise. Recommandations detinees aux municipalites: comment peuvent-elles s'adapter a leurs nouveaux roles dans un marche liberalise?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Even if the liberalization of energy markets seems to make it more difficult, it also creates opportunities for the committed local authority. Local authorities fulfill their functions in the energy sphere via a number of roles: as a consumer of energy, as a producer of energy, as a distributor of energy, as a trader of energy, as a regulator, planner and policy maker regarding energy using activities, as an awareness tool of the issues relating to energy use and as a provider of incentives to improve energy performance. There are impacts of liberalization on each of these roles. In most, liberalization has not actually changed what they do, only the degree of attention that should be given to it. Only in those areas where trading is involved are new skills necessary, for instance in purchasing energy, in transporting one own energy and in trading energy. In this framework, the following topics are successively analyzed: Improving performance as an energy consumer, improving performance as an energy producer, improving performance as an energy trader, improving performance as an energy distributor, improving performance in delivering sustainable, energy policies at local level and improving performance as a facilitator and awareness programs. (A.L.B.)

  7. L'impact d'un Système Public d'Information sur l'intégration et l'efficacité des marchés : une application du modèle "Parity Bounds" au cas du maïs au Bénin

    Directory of Open Access Journals (Sweden)

    Kpenavoun Chogou, S.

    2013-01-01

    Full Text Available Measuring the impact of Public Market Information Systems on market integration and efficiency: an application of the Parity Bounds Model in maize markets in Benin. During the 1990s, agricultural market reforms prevailed within the economic liberalization undertaken in many sub-Saharan countries. In these countries, government intervention in the commodity markets through marketing boards or parastatal organizations was abandoned in favor of new market reforms. Public Market Information Systems (PMIS thus emerged as part of these reforms. Even though great positive impacts were expected from these reforms, little empirical work has been carried out to evaluate their effects. This article investigates how PMIS has affected the market performance of maize, a major staple food crop in Benin. We use a modified version of the Parity Bounds Model (PBM. This method allows the estimation of the rates of spatial market efficiency or integration, but also the estimation of the rates of market arbitrage, autarky, profitable opportunities and the violation of market arbitrage conditions. Results showed that Benin's agricultural sector suffered from a lack of quality training in how to follow the government-supported market information system implemented in the early 1990s. Subsequently, PMIS did not significantly improve the degree of market integration, although the reforms did induce new marketing opportunities. Results also showed that the impact of PMIS is limited by other market imperfections, such as entry barriers for non-residents or for persons not in local informal trade organizations, and the non-transparent enforcement of formal regulations. This study therefore recommends the implementation of more efficiency-raising policies in order to encourage competition and to allow PMIS to fulfill the expectations of farmers and consumers. Improving food producers and traders' access to reliable information will allow them to better exploit the market opportunities induced by the reforms.

  8. Efficacité des méthodes de lutte contre le développement de cinq espèces de plantes invasives amphibies : Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides et Myriophyllum aquaticum (synthèse bibliographique)

    OpenAIRE

    Delbart, E.; Mahy, G.; Monty, A.

    2013-01-01

    Effectiveness of techniques used to control the development of five invasive amphibious plant species: Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides and Myriophyllum aquaticum. A review. Among rapidly spreading invasive species in Europe, amphibious plants are particularly problematic. These plants are capable of developing a photosynthetic activity both below and above the water surface, and they typically form dense floating populations. Controlling a...

  9. Efficacité des méthodes de lutte contre le développement de cinq espèces de plantes invasives amphibies : Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides et Myriophyllum aquaticum (synthèse bibliographique

    Directory of Open Access Journals (Sweden)

    Delbart, E.

    2013-01-01

    Full Text Available Effectiveness of techniques used to control the development of five invasive amphibious plant species: Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides and Myriophyllum aquaticum. A review. Among rapidly spreading invasive species in Europe, amphibious plants are particularly problematic. These plants are capable of developing a photosynthetic activity both below and above the water surface, and they typically form dense floating populations. Controlling amphibious plants, whether for the purposes of total eradication or for the regulation of their spread, represents an important challenge for managers. A literature review of existing control methods for Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides and Myriophyllum aquaticu was carried out, taking into account efficiency and costs. Of the 87 studies analyzed, a great variation was evident in the research efforts undertaken (number and spatial scale of studies between species and between control methods. However, overall, the different control methods described showed a similar level of efficiency between species. Reports of total eradication of amphibious plants were rare. Such cases resulted from the application of mechanical or chemical methods, most often coupled with complementary methods such as manual finishing. The use of chemical control methods (less laborious and costly than others was found to be frequently documented in the literature. However, except in the case of some active substances, such chemical methods were found to provide low control efficiency. Similarly, to date, biological control has not been found to provide convincing results. In addition, it should be noted that several biological control agents are considered as invasive species in Europe. On the other hand, although little related research has been carried out, methods such as manual or mechanical removal with manual finishing have often been found to result in satisfactory control levels. Aware of the difficulty of controlling amphibious plants, as well as the potential collateral damage caused by control methods to aquatic ecosystems, we argue that consensus still needs to be found between scientists, decision-makers and managers before decisions at regional or national scale can be made.

  10. Effectiveness of Exchange Rate Policy for Trade Account Adjustment (Efficacité la politique en matière de taux de change pour l'ajustement du solde commercial) (Efecto de la política de tipos de cambio en el ajuste de la balanza comercial)

    OpenAIRE

    Alfred Steinherr

    1981-01-01

    In the past, exchange rate policy has often failed to redress the current account within a medium-run framework of three to six years and in some cases has even led to an accentuation of the imbalance. Typical examples are Japan, the Federal Republic of Germany, and the United States during the late 1960s up to the late 1970s. It is not easy to understand these "perverse" or sluggish effects of exchange rate policy on the basis of existing economic theory. The only explanations offered by thi...

  11. Traitement diététique de l'hypercholestérolémie légère à modérée. Efficacité de différentes interventions.

    OpenAIRE

    Gosselin, P.; Verreault, R.; Gaudreault, C.; Guillemette, J.

    1996-01-01

    OBJECTIVE: To compare the efficacy of brief dietary intervention by family physicians in their daily practice and in group sessions to standard dietetic treatment in mild to moderate hypercholesterolemia. DESIGN: Randomised clinical trial. SETTING: Family practice clinic in a remote community. PARTICIPANTS: Between September 1, 1991 and September 30, 1992, 135 men and women between 20 and 60 years old with mild to moderate hypercholesterolemia were recruited and randomly assigned to three tre...

  12. Efficacité comparée de divers procédés physiques de séparation des argiles d'un sable de gisement A Comparison of Different Physical Processes for the Recovery of Clays from an Unconsolidated Sandstone

    Directory of Open Access Journals (Sweden)

    Yvon J.

    2006-11-01

    Full Text Available Divers procédés physiques (mixage, attrition, vibration ultra-sonique ont été utilisés pour désagréger et disperser les argiles d'un sable de gisement. Le traitement aux ultra-sons s'est avéré le plus efficace : après 10 min de vibration on récupère environ 1,5 fois plus de particules fines ( The characterizing of clays is an essential operation for understanding many problems encountered in production. It goes via a preliminary phase in which species are separated quickly and effectively without altering their nature. Chemical processes disperse clays by solubilizing their cements, amorphous compounds and poorly crystallized oxyhydroxides. But they attack fragile species and lead to mistaken results. Therefore, we have chosen various physical processes (mixing, attrition, ultrasonic vibration and compared their efficacy with a reservoir sand. This sand was a quartzose arenite in which 96. 6 % of the grains were between 63 µm and 2 mm. The < 40 µm fine fraction, obtained by wet sieving, represented 2. 44 % of the unprocessed sand, and the clayey fraction (kaolinite, illite, montmorillonite, interstratified illite-montmorillonite was 1. 20%. Mixing was done with a bladed stirer. 40 g of sand and 100 cm³ of demineralized water were stirred for 3 min at a speed of 3000 rpm. Attrition was done by two devices :(1 For attrition by rotation, 400 g of sand and 0. 5 liter of demineralized water were placed in a porcelain jar rotating at a speed of 37 rpm. Tests were performed with water alone and with the adding of a dispersant (0. 3 % sodium hexametaphosphate and a surfactant (0. 6 mole/liter of sodium sulfonate paraoctylphenyl. (2 Attrition by a Turbula TC2 mixer, which gave the jar a complex rotation movement including shaking and rhythmic rocking. 500 g of sand were thus processed in 1 literof 3 % sodium hexametaphosphate solution for varying times. Ultrasonic processing was done with a Sonifer 830 device. The probe was plunged into a suspension made up of 440 g of sand and 300 cm³ of demineralized water processed for times varying from 5 to 100 min. The efficacy of the processing was measured by the weight percent of the < 40 µm fraction. This percentage was 2. 08 % on the average for mixing, 2. 60 % for simple rotation and 2. 87% for rotation by the Turbula device. The adding of dispersant or surfactant had no significant effect. Increasing the rotation time had a minimal effect, in that the percentage of particles recovered went from 2. 21 to 2. 60 % when time increased from 6 to 24 h. Ultrasonic processing was by far the most efficacious and fastest. Indeed, after 5min, an average of 3. 60% of < 40 µm particles was recovered, 4. 10 % after 10 min and7. 18 % after 100 min. The SEM examination of the fractions processed showed that only ultrasonic processing was capable of recovering all of the free clays, either pellicular or trapped in the dissolution cavities or cracks of the quartz grains, i. e. the so-called activeclays. It was also found that this recovery is selective. Montmorillonite and illite are set free at the beginning, while kaolinite is released all during the tests. At the beginning, it was disordered kaolinite, but after 15-20 min of processing, it was ordered kaolinite coming from the microdivision of mica crystals with which it had been associated. This microdivision is clearly visible, moreover, on the cumulative grain-size curve of the < 40µm particles recovered after ultrasonic processing. This curve has two parts:(1 The first part has a steep positive slope linked to the recovery of activeclays. (2 The second part has a much gentler slope linked to the recovery of clayey aggregates and mica and quartz grains microdivided by ultrasounds. The tests performed and a bibliographic study of various processes and operating conditions led us to choose ultrasounds as the process for separating clays from a reservoir sand. The best results were obtained with the following experimental conditions : instrument frequence = 200 kHz, instrument power = 210 W, suspension = 40 g

  13. Efficiency of the metabolic radiotherapy with {sup 177}Lu Octreotate in the case of gastric endocrine tumor with hepatic metastases; Efficacite de la radiotherapie metabolique au{sup 177}Lu Octreotate dans le cas d'une tumeur endocrine gastrique avec metastases hepatiques

    Energy Technology Data Exchange (ETDEWEB)

    Leghzali Moise, H.; Besse, H.; Stievenart, J.L [Medecine nucleaire, hopital Beaujon, AP-HP, (France); Scigliano, S. [service hospitalier Frederic-Joliot, Orsay, (France); Mortazavi Jehannod, N.; Lebtahid, R.; Le Guludec, D. [medecine nucleaire, hopital Bichat, AP-HP, (France); Ruszniewski, P. [pancreato-gastroenterologie, hopital Beaujon, AP-HP, (France)

    2009-05-15

    The therapy means of evolved, metastases or inoperable forms of digestive endocrine tumors are limited. we illustrate a case of treatment efficiency by {sup 177}Lu-Octreotate of a well differentiated gastric endocrine tumor with hepatic metastases. conclusions: the metabolic radiotherapy of endocrine tumors constitute a new alternative of conventional treatments, showing the achievement of objective tumor responses at advanced stages, and in failure of conventional treatments. it is necessary to identify the predictive factors of the therapy response in order to optimize the results and to limit the toxicity. (N.C.)

  14. Opinion of Energie-Cites on: proposal for a directive of the European parliament and of the council; Avis d'Energie-Cites sur la: proposition de directive du parlement Europeen et du conseil relative a l'efficacite energetique dans les utilisations finales et aux services energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-01

    This proposal, focusing on the promotion of end-use efficiency, should be regarded as a necessary instrument to complement the recently adopted legislation on the opening of the internal energy market, which mainly leads to efficiency improvements on the supply side. Memorandum Considering that the functioning of the energy market does not allow ''market forces to allocate economic and natural resources effectively'' and that measures should be taken to improve this, the Commission draws up a list of the main obstacles and presents objectives. The technical potential for savings is at about 40%. The economic cost-effective savings potential is at about 20%, 22% in the buildings sector. The general target is 1 % savings per year. The 1,5 % target in the public sector is therefore more ambitious that the general target. According to the Commission, energy efficiency is a strategy to deal with scarce public funds while at the same time addressing serious energy and climate challenges, using the concept of leadership by example. It presents also the economic impact of energy savings targets and explains the reasons why the local authorities are affected by the proposed directive (Municipalities are energy consumers, the municipalities are energy distributors and/or retailers, the municipalities are planners/investors, the municipalities are motivators and local growth and employment are of concern to local authorities). (A.L.B.)

  15. Opinion of Energie-Cites on: Proposals for a directive of the European Parliament and of the Council; Avis d'Energie-Cites sur la: proposition de directive du parlement europeen et du conseil relative a l'efficacite energetique dans les utilisations finales et aux services energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-01

    The Proposal for a Directive on energy end-use efficiency and energy services, published in December 2003, is intended to develop and encourage energy efficiency on the demand side, in particular that provided by utilities and related services companies in the form of energy services, since promoting energy services is an important element for reducing greenhouse gas emissions. This proposal, focusing on the promotion of end-use efficiency, should be regarded as a necessary instrument to complement the recently adopted legislation on the opening of the internal energy market, which mainly leads to efficiency improvements on the supply side. (A.L.B.)

  16. Security of energy supplies: the arguments of Mrs Loyola de Palacio. Nuclear energy: exit or restart. The Europe of renewable energies and energy efficiency; Securite d'approvisionnement energetique: les arguments de Mme Loyola de Palacio. Energie nucleaire: sortie ou relance. L'Europe des energies renouvelables et de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Palacio, L. de [Commission Europeenne de l' Energie et des Transports, 75 - Paris (France); Pierret, C. [Ministere de l' economie, des finances et de l' industrie, 75 - Paris (France); Schwartzenberg, R.G. [Ministere de la recherche, 75 - Paris (France); Bataille, C. [Assemblee Nationale, 75 - Paris (France); Bisson, E. [Direction Generale de l' Energie et des Matieres Premieres, 75 - Paris (France)

    2002-07-01

    This issue of Energies et Matieres Premieres journal comprises 3 articles. The first article is a reprint of the talk given by Mrs Loyola de Palacio at the French Institute of International Relations (IFRI) on July 5, 2001 about a safe and durable European strategy of energy supplies based on energy saving, on the development of renewable energy sources and on the role of nuclear energy in the fight against climate changes. The second article is a reprint of the talks given by C. Pierret (French State Secretary of Industry), by R.G. Schwartzenberg (French Minister of Research), by C. Bataille (Depute of the Nord region) and by the different participants to the round table of the colloquium on nuclear energy organized on November 6, 2001. The aim of the colloquium was to debate of the role the nuclear energy will have in the future energy and environmental challenges considering the increasing world energy demand and the reduction of greenhouse gases emissions. The last article deals with the 5. and 6. European R and D programs for the sustain of renewable energies and energy mastery. (J.S.)

  17. Prognosis value of the COX-2 expression on radiotherapy efficiency and on survival without progression of patients reached by an unoperative glioblastoma; Valeur pronostique de l'expression de COX-2 sur l'efficacite de la radiotherapie et sur la survie sans progression des patients atteints d'un glioblastome inoperable

    Energy Technology Data Exchange (ETDEWEB)

    Simon, J.M.; Mazeron, J.J. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Service de Radiotherapie Oncologique, 75 - Paris (France); Mokhtari, K. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Lab. de Neuropathologie, 75 - Paris (France); Genestie, C. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Lab. d' Anatomie Pathologique, 75 - Paris (France); Bissery, A. [Groupe Hospitalier de la Pitie-Salepetriere, APHP, Dept. de biostatistiques et d' Anformation Medicale, 75 - Paris (France); Jaillon, P. [Hopital Saint-Antoine, Service de Pharmacologie, 75 - Paris (France)

    2006-11-15

    The expression of COX-2 is a prediction factor of the lack of response to the radiotherapy of glioblastomas and a less good survival rate without tumor progression, aside other known prognosis factors. These results suggest a selective treatment by an anti-COX-2 could have a radiosensitizer contribution during the radiotherapy of glioblastomas. (N.C.)

  18. In vivo preclinical low field MRI monitoring of tumor growth following a suicide gene therapy in an ortho-topic mice model of human glioblastoma;Controle par IRM bas champ in vivo de l'efficacite d'une therapie genique par gene suicide dans un modele murin de glioblastome orthotopique

    Energy Technology Data Exchange (ETDEWEB)

    Breton, E.; Goetz, Ch.; Aubertin, G.; Constantinesco, A.; Choquet, Ph. [Service de biophysique et medecine nucleaire, hopital de Hautepierre, CHRU de Strasbourg, 67 - Strasbourg (France); Institut de mecanique des fluides et des solides, CNRS, universite de Strasbourg, 67 - Strasbourg (France); Kintz, J.; Accart, N.; Grellier, B.; Erbs, Ph.; Rooke, R. [Transgene SA, parc d' innovation, 67 - Illkirch Graffenstaden (France)

    2010-03-15

    Purpose The aim of this study was to monitor in vivo with low field MRI growth of a murine ortho-topic glioma model following a suicide gene therapy. Methods The gene therapy consisted in the stereotactic injection in the mice brain of a modified vaccinia virus Ankara (M.V.A.) vector encoding for a suicide gene (FCU1) that transforms a non toxic pro-drug 5-fluoro-cytosine (5-F.C.) to its highly cytotoxic derivatives 5-fluorouracil (5-F.U.) and 5-fluoro-uridine-5 monophosphate (5-F.U.M.P.). Using a warmed-up imaging cell, sequential 3D T1 and T2 0.1T MRI brain examinations were performed on 16 Swiss female nu/nu mice bearing ortho-topic human glioblastoma (U 87-MG cells). The 6-week in vivo MRI follow-up consisted in a weekly measurement of the intracerebral tumor volume leading to a total of 65 examinations. Mice were divided in four groups: sham group (n = 4), sham group treated with 5-F.C. only (n = 4), sham group with injection of M.V.A.-FCU1 vector only (n = 4), therapy group administered with M.V.A.-FCU1 vector and 5-F.C. (n = 4). Measurements of tumor volumes were obtained after manual segmentation of T1- and T2-weighted images. Results Intra-observer and inter-observer tumor volume measurements show no significant differences. No differences were found between T1 and T2 volume tumor doubling times between the three sham groups. A significant statistical difference (p < 0.05) in T1 and T2 volume tumor doubling times between the three sham groups and the animals treated with the intratumoral injection of M.V.A.-FCU1 vector in combination with 2 weeks per os 5-F.C. administration was demonstrated. Conclusion Preclinical low field MRI was able to monitor efficacy of suicide gene therapy in delaying the tumor growth in an in vivo mouse model of ortho-topic glioblastoma. (authors)

  19. Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients. Results of the French RTF1 phase 2 trial; Tolerance et efficacite de la radiotherapie de conformation en cas de carcinome hepatocellulaire chez le patient cirrhotique. Resultats de l'essai de phase II RTF1

    Energy Technology Data Exchange (ETDEWEB)

    Mornex, F.; Girard, N.; Wautot, V.; Khodri, M. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Merle, P.; Kubas, A.; Trepo, C. [Hopital de l' Hotel-Dieu, Service d' hepatogastroenterologie, 69 - Lyon (France); Beziat, C. [Hopital de l' Hotel-Dieu, Dept. de Radiologie, 69 - Lyon (France)

    2005-11-15

    Purpose. - While some patients presenting with hepatocellular carcinoma (HCC) benefit from curative therapies (transplantation, surgery, percutaneous ablation), others are only candidates for palliative options such as chemo-embolization or symptomatic care. Although conventional external-beam radiotherapy of the liver is regarded as little efficient and potentially toxic in cirrhotic patients, 3-dimensional conformal radiotherapy (CRT), by decreasing the amount of normal liver included in the radiation portal, allows dose escalation to occur without increasing the risk of radiation-induced hepatitis. This trial was designed to assess the efficacy and tolerance of CRT for small-size HCC in cirrhotic patients. Patients and methods. - Prospective phase II trial including stage A/B cirrhotic patients with small-size HCC not suitable for curative treatments; CRT consisted in a standard fractionation radiation, with a total dose of 66 Gy. Results. - Twenty-seven patients were included, 15 of whom had previously been treated for HCC; mean age was 68. Among the 23 assessable patients, 18 (78%) presented with complete response, 3 (13%) with partial response, and 2 with no response. Acute complications occurred in 24 patients, and were mainly acceptable (grade 1/2: 22 patients, grade 3/4: 11 patients, 4 (15%) of whom had clinical and/or hematological toxicities). Only 2 (9%) grade 3/4 clinical and/or hematological late toxicities are reported. Conclusion. - CRT is a non-invasive curative technique highly suitable for small-size HCC in cirrhotic patients; further investigations are needed to compare it to the other available treatments, and to integrate it into the curative therapeutic algorithm of HCC. (author)

  20. Absorption Physique de Composés Organiques Volatils par Pulvérisation d'Emulsion d'Huile dans l'Eau (Etude thermodynamique et hydrodynamique - Application au calcul des efficacités d'abattement de COV sur effluents synthétiques et réels)

    OpenAIRE

    TATIN, Romuald

    2008-01-01

    Les Composés Organiques Volatils peuvent être des composés malodorants, cancérigènes, tératogènes ou mutagènes. En France, la pollution odorante représente le second motif de plainte après le bruit. En conséquence, des réglementations de plus en plus strictes sont imposées aux industriels en termes d’émission de COV. Dans les stations d’épuration, les composés de nature lipophile ne sont pas bien traités par les tours de lavage chimique de la filière de désodorisation. L’élimination de ces co...

  1. The School of Veterinary Medicine in St-Hyacinthe : energy efficiency and air quality, an inherent part of the new facility; Le CHUV de St-Hyacinthe : l'efficacite energetique et qualite de l'air, partie inherente des nouvelles installations

    Energy Technology Data Exchange (ETDEWEB)

    Havard, R. [SNC Lavalin, Montreal, PQ (Canada)

    2010-09-15

    This article described the expansion and modernization of the Centre Hospitalier Universitaire Veterinaire (CHUV) at the University of Montreal. The $74 million retrofit project at the School of Veterinary Medicine began in 2001 and was completed in 2008. The facility is considered to be a forerunner in the agribusiness. The facility can accommodate over 400 students at 3 different types of hospitals for pets, birds of prey, exotic animals, farm animals and equidae. Many challenges were addressed, including indoor air quality which requires specialized control for air temperature, humidity, and rigorous control of the dispersion of contaminants to ensure safety in each space. In addition to reliability, the infrastructure plan had to ensure exemplary energy performance and a reduction in costs. The energy system relies on a combination of electricity, natural gas and heat pumps for heating and cooling the premises. A novel ventilation system was designed to keep the operating rooms free of contaminants and to block contaminants from adjoining rooms. Contagious rooms requiring isolation are kept in slightly negative pressure, and air from these rooms is vented to the outside. It was concluded that the newly modernized facility meets the stringent conditions for thermal comfort in an energy efficiency manner. 3 figs.

  2. Etude de l'efficacité de la fonctionnalisation des acides aminés au MTBSTFA après hydrolyse acide et dans différentes matrices minérales analogues martiennes : application aux expériences Sample Analysis at Mars (SAM) et Mars Organic Molecule Analyzer (MOMA)

    OpenAIRE

    Brault, Amaury

    2015-01-01

    Three main ways of study allow us to search for traces of life in the Universe: remote analysis, laboratory analysis of extraterrestrial material fallen or brought back to Earth, and in situ analysis. In association with chemical derivatization, Gas Chromatography coupled to Mass Spectrometry (GC-MS) is the method of predilection used for the separation and identification of organic compounds of astrobiological interest, whether on Earth or beyond. This work firstly deals with the impact of s...

  3. Adjuvant irradiation in breast cancer patients with A.T.M. gene heterozygous mutations: Special focus on clinical efficacy/toxicity; Toxicite et efficacite de la radiotherapie adjuvante chez les patientes traitees pour un cancer du sein et porteuses d'une mutation heterozygote du gene de l'ataxie-telangiectasie

    Energy Technology Data Exchange (ETDEWEB)

    Chargari, C.; Kirova, Y.M.; Even, C.; Monnier, L.; Dendale, R.; Campana, F.; Fourquet, A. [institut Curie, Dept. de Radiotherapie, 75 - Paris (France); Chargari, C. [Hopital d' Instruction des Armees du Val-de-Grace, Service d' Oncologie Radiotherapie, 75 - Paris (France)

    2009-06-15

    Dysfunction of the ataxia telangiectasia mutated (A.T.M.) gene has been related to defective cell cycle control and genomic instability due to the impaired repair of DNA double strand breaks. Although increased radiosensitivity in A.T.M. heterozygous patients has been suggested in preclinical data, clinical implication of A.T.M. variant remains debated. Despite frequent in vitro hypersensitivity in patients with severe radiation-induced delayed toxicity, heterozygoty for A.T.M. gene does not represent the major cause of unexpected complications after radiation therapy. This might be partially due to potential coexistence of alterations in additional genes that would play a role in development of late radiation-induced adverse response. Although several data suggest that some A.T.M. polymorphisms would increase grade 3 subcutaneous fibrosis at lower doses compared with patients who did not possess these genetic alterations, the relationship between the presence of A.T.M. mutations or sequence variants and radiation-induced toxicity remains controversial in part because of their biological and functional significance. Considering the lack of prospective data, patients with A.T.M. mutation should be considered as candidates for both dose volume and dose reduction clinical trials. (authors)

  4. Analyse de l'efficacité des stratégies de travail d'étudiants Lansad à distance dans un dispositif hybride – Étape d'une recherche-action Action research to evaluate ESP students' off site working strategies in a blended learning environment – interim report

    Directory of Open Access Journals (Sweden)

    Cédric Brudermann

    2010-05-01

    Full Text Available Cet article se propose de revenir sur la conception et l'utilisation d'un centre de ressources en ligne visant à mettre en œuvre des expériences d'apprentissage (Bange, 1992 potentiellement favorables à l'acquisition de l'anglais langue étrangère, dans un dispositif hybride d'enseignement / apprentissage des langues pour spécialistes d'autres disciplines (désormais Lansad. Une recherche expérimentale menée à l'institut universitaire de formation des maîtres (désormais IUFM de Perpignan auprès d'un public de professeurs des écoles de niveau B1 / B2 au cours de l'année universitaire 2007-2008 a permis de recueillir des données plus précises quant aux besoins des apprenants au cours de la réalisation de tâches écrites et orales à distance. Leur traitement a montré que la plupart des obstacles provenaient d'aspects de la langue anglaise de niveau A2 / B1 qui avaient déjà été travaillés par les apprenants lors de leurs études dans le secondaire. Pour les aider, un "centre de ressources en ligne" fonctionnant d'après leurs besoins en L2 a été conçu (Brudermann, 2008, de façon à leur laisser toute latitude pour se prendre en charge dans un climat sécurisé lors de la réalisation de ces travaux et les conduire à réinvestir leurs acquis dans l'élaboration de tâches ultérieures (Van Harmelen, 2006.This article deals with the implementation of an online database of pedagogical resources in a blended learning device, in order to lead ESP students to a potential improvement of their English as a foreign language knowledge. Action research was carried out in 2007-2008 in a French University (Perpignan amongst B1/B2 teachers-to-be ESP students. The data collected showed that most linguistic obstacles derived from A2/B1 elements they had already been taught during their secondary education. A database of pedagogical resources was set up online to provide students with relevant items and links when needed, whilst doing tasks and help them reinvest and reflect upon their FL knowledge (Van Harmelen, 2006.

  5. Intelligent networks: evolution or revolution? Source of energy efficiency or economical optimisation? For who's benefit?; Reseaux intelligents: evolution ou revolution? Source d'efficacite energetique et/ou d'optimisation economique? Au benefice de qui?

    Energy Technology Data Exchange (ETDEWEB)

    Fontaine, Christian

    2010-09-15

    The electricity sector has experienced a slow evolution. Renewable production developments and telecommunications and computers usage will bring major changes with hard to predict effects. Computerized management of production and local storage combined to a certain mastering of the allowed consumption by home automation could improve reliability and the final price for consumers. This change offers great opportunities but also risks of failures, both financial and technical. The regulators have a major role to play in order to understand the concrete gains of the technological propositions and to regulate the investment costs involved. [French] Le secteur de l'electricite a connu une evolution lente. Le developpements des productions renouvelables, l'utilisation des telecommunications et de l'informatique provoquera un bouleversement majeur dont il est difficile de prevoir l'ampleur. La gestion automatisee des productions et stockages locaux combinee a une certaine maitrise de la consommation permise par la domotique pourrait ameliorer la fiabilite et le prix final pour les consommateurs. Ce changement presente de grandes opportunites mais aussi des risques d'echecs, tant financiers que techniques. Les regulateurs ont un role majeur a jouer pour comprendre les gains concrets des propositions technologiques et reguler les couts d'investissement qu'elles impliquent.

  6. Relationship Between Chemical Structure and Effectiveness of Some Metallic Dialkyl and Diaryldithiophosphates in Different Lubricated Mechanisms Relations entre la structure chimique et l'efficacité de quelques dialkyles et dialkylaryldithiophosphates métalliques dans différents mécanismes lubrifiés

    Directory of Open Access Journals (Sweden)

    Born M.

    2006-11-01

    Full Text Available The antiwear (AW and extreme-pressure (EP properties of some metallic dialkyl and diaryidithiophosphates (MDTP, including zinc, have been studied in different metal/metal contact conditions : four-ball and FZG rigs. We have noted :- With pure dialkyldithiophosphates of different divalent metals (Zn, Cd, Cu, Pb, Ni, Co, prepared from the same alcohol :(a On the four-ball rig, EP results, expressed in terms of load-wear index, show that the highest performances are obtained with ZnDTP, but statistically the higher the ionic radius of the metal, the better the performance. EP results, expressed in terms of weld load, do not show any difference between these MDTP. (b On the four-ball rig, AW results, expressed in terms of wear scar, show that the highest performances are obtaine with ZnDTP; beyond a certain value these performances with Zn and Pb are almost independent of the concentration. For the other metallic DTP, there is a very close relationship between performance and concentration. (c On the FZG gear rig, EP-AW results, expressed in terms of failure load stage and specific wear, show that statistically, the higher the ionic radius of the metal, the better the performance. - With ZnDTP :(a On the four-ball rig, EP results, expressed in terms of load wear index, do not depend on the chemical structure of the alcohol used for synthetized ZnDTP, but if results are expressed in terms of weld load, better performances are obtained with ZnDTP synthetized from secondary alcohols. AW results show that the effectiveness of ZnDTP from secondary alcohols is slightly higher when the alcohols used contain less than six carbon atoms. Beyond six carbon atoms in primary or secondary alcohol molecules, performances decrease. (b On the FZG gear rig, EP-AW results show that performances do not depend on the primary or secondary nature of the alcohols used, and that the smaller the hydrocarbon chain of these alcohols, the better the performances. The results of this work indicate that ZnDTP is the most effective of the MDTP we have studied. For ZnDTP prepared from different alcohols and alkylphenols the performances depend not only on the chemical structure of the additive, but also on contact conditions (kinematic, material types, etc. , and on the criteria considered (seizure load, weld load, wear, etc. Cet article apporte une contribution aux connaissances sur les performances antiusure et extrême-pression des dialkyldithiophosphates métalliques en général, et des dialkyldithiophosphates de zinc en particulier. Elle montre les différences de comportement antiusure et extrême-pression de ces composés dans des contacts métalliques lubrifiés caractéristiques tels que la classique machine 4 Billes et, ce qui constitue en soit une originalité, la machine à engrenages FZG. Elle souligne aussi que les performances enregistrées, sur une machine d'essais donnée, dépendent des critères d'appréciation choisis.

  7. AQME memorandum to better understand the complexity of energy efficiency and its contribution to Quebec's energy sector; AQME memoire pour mieux comprendre la complexite de l'efficacite energetique et sa contribution au secteur energetique du Quebec

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-12-23

    This memorandum is the result of consultations that were undertaken in Quebec with respect to the energy sector. The report discusses energy safety both from a local and international perspective. It also examines several issues related to energy efficiency including: energy prices; barriers to energy efficiency; energy efficiency in buildings; energy efficiency in the public, commercial, and the residential sectors; as well as energy building regulations both for existing and new buildings. Energy efficiency is also examined from the perspectives of the industrial sector and the transport sector and from a public sensitization perspective. Last the report presents a national energy efficiency plan including a potential evaluation and discusses recommendations for partnerships to improve energy effectiveness. 4 tabs., figs.

  8. Monte Carlo molecular simulations: improving the statistical efficiency of samples with the help of artificial evolution algorithms; Simulations moleculaires de Monte Carlo: amelioration de l'efficacite statistique de l'echantillonnage grace aux algorithmes d'evolution artificielle

    Energy Technology Data Exchange (ETDEWEB)

    Leblanc, B.

    2002-03-01

    Molecular simulation aims at simulating particles in interaction, describing a physico-chemical system. When considering Markov Chain Monte Carlo sampling in this context, we often meet the same problem of statistical efficiency as with Molecular Dynamics for the simulation of complex molecules (polymers for example). The search for a correct sampling of the space of possible configurations with respect to the Boltzmann-Gibbs distribution is directly related to the statistical efficiency of such algorithms (i.e. the ability of rapidly providing uncorrelated states covering all the configuration space). We investigated how to improve this efficiency with the help of Artificial Evolution (AE). AE algorithms form a class of stochastic optimization algorithms inspired by Darwinian evolution. Efficiency measures that can be turned into efficiency criteria have been first searched before identifying parameters that could be optimized. Relative frequencies for each type of Monte Carlo moves, usually empirically chosen in reasonable ranges, were first considered. We combined parallel simulations with a 'genetic server' in order to dynamically improve the quality of the sampling during the simulations progress. Our results shows that in comparison with some reference settings, it is possible to improve the quality of samples with respect to the chosen criterion. The same algorithm has been applied to improve the Parallel Tempering technique, in order to optimize in the same time the relative frequencies of Monte Carlo moves and the relative frequencies of swapping between sub-systems simulated at different temperatures. Finally, hints for further research in order to optimize the choice of additional temperatures are given. (author)

  9. NEOPLASMS

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920632 Phenotypic analysis of T lympho-cytes from the patient with thymoma com-plicated with pure red cell aplasia. LIUBai(刘白), et al. Beijing Med Univ. Chin J Hema-tol 1992; 13(5): 244-246. The thymocytes in thymoma tissue and mono-nuclear cells in peripheral blood and bone marrowwere obtained from a patient with thymomacomplicated with pure red cell aplasia. The

  10. Radial, renal and craniofacial anomalies: Baller-Gerold syndrome

    Directory of Open Access Journals (Sweden)

    Murthy Jyotsna

    2008-01-01

    Full Text Available The Baller-Gerold syndrome is a rare syndrome with very few cases published in literature. Craniosynostosis and radial aplasia are striking features, easy to diagnose. However, there are many differential diagnoses. Often, the question raised is whether the Baller-Gerald syndrome is a distinct entity. We report a patient with findings of craniosynostosis and radial aplasia consistent with the diagnosis of the Baller-Gerold syndrome. Genotypic heterogeneity could possibly underlie the phenotypic variability exhibited by these cases.

  11. Intra-operative implantation of Gliadel (BCNU, carmustine) wafers in patients suffering from a multiform glioblastoma and which are to be submitted to a concomitant radiotherapy and chemotherapy by temozolomide according to the Stupp protocol: efficiency and toxicity; Implanation peroperatoire de pastilles de Gliadel (BCNU, carmustine) chez des patients atteints d'un glioblatome multiforme devant recevoir par la suite une radiotherapie et une chimiotherapie concomitante par temozolomide selon le protocole de Stupp: efficacite et toxicite

    Energy Technology Data Exchange (ETDEWEB)

    Miglierini, P.; Bouchekoua, M.; Rousseau, B.; Malhaire, J.P.; Pradier, O. [Service de radiotherapie, ICH, CHU Morvan, 29 - Brest (France)

    2010-10-15

    The author report a study aimed at assessing the tolerance and efficiency of a technique which has been used for some years and which comprises the implantation of Gliadel wafers in the operative bed before performing a concomitant radiotherapy and chemotherapy with temozolomide, followed by six adjuvant chemotherapy sessions with the Stupp protocol. Four women and seven men have been implanted with Gliadel wafers. Only one patient did not have the concomitant chemo-radiotherapy. The global survival and global survival without progression have been assessed. Even though the obtained results are encouraging, the concomitant chemo-radiotherapy had to be stopped for three patients due to haematological consequences. Short communication

  12. Report made on behalf of the inquiry commission for the enforcement of the measures preconized for the safety of the maritime transport of hazardous or polluting products and for the evaluation of their efficiency; Rapport fait au nom de la commission d'enquete sur l'application des mesures preconisees en matiere de securite du transport maritime des produits dangereux ou polluants et l'evaluation de leur efficacite

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    On February 5, 2003, three years after the creation of an inquiry commission about the Erika tanker-ship wreck, the principle of a new inquiry commission about the safety of maritime transports was decided by the French house of commons. Its mission is: to evaluate the efficiency of the existing measures of prevention of marine pollution by hydrocarbons, to examine if the preconized safety measures for the transport of dangerous or polluting products are effectively enforced, and to evaluate the status of the transposition of the European directives relative to the control of hazardous ships. This document is the first tome of the report made on behalf of this inquiry commission. It comprises four parts dealing with: 1 - the Prestige tanker-ship wreck and the pollution of Spanish and French coasts: similarities with the Erika wreck but differences in the conditions of crisis management, diverging accident analyses, problems encountered in Spain, a significantly improved management of the crisis by the French administration, the public opinion and the local economy, the global increase of maritime transport and the reduction of accidents frequency; 2 - the real improvements after the Erika wreck: the significant advances but their partial implementation, the acceleration of actions following the Prestige wreck; 3 - the expected and realistic perspectives: the sustain of the political will at the national scale, the concretizing of the European decisions and the follow up of the retained trends, the need for more outstanding evolutions at the international scale; 4 - the international liability and compensation regime: its limitation to the hydrocarbons pollution, the lack of victims indemnification in the case of chemical pollution, the need for an increase of the liability of all actors of the maritime transport and the improvement of the compensation system, a community compensation fund to compensate the inefficiencies of the international compensation mechanisms. (J.S.)

  13. New modalities (setting, fractionation) of radioimmunotherapy by {sup 90}Y-ibritumomab tiuxetan ({sup 90}Y zevalin) in first line treatment of follicular type non Hodgkin malignant lymphomas: efficiency, toxicity and personalized dosimetry approach; Nouvelles modalites (consolidation, fractionnement) de radioimmunotherapie par {sup 90}Y-ibritumomab tiuxetan (Zevalin) en traitement de premiere ligne des lymphomes malin non hodgkiniens de type folliculaire: efficacite, toxicite et approche dosimetrique personnalisee

    Energy Technology Data Exchange (ETDEWEB)

    Morschhauser, F

    2008-12-15

    Rationale: radioimmunotherapy (R.I.T.) with {sup 90}Y-ibritumomab tiuxetan ([{sup 90}Y] Zevalin ) is a new treatment option for patients with relapsed/refractory non Hodgkin follicular lymphoma (F.L.). Efficacy increases when Zevalin is used earlier in the disease course. Currently, Zevalin dosage is based on weight and not dosimetry. This most likely results in a wide range of absorbed dose to critical organs and tumor, which in turn translates in unpredictable efficacy and toxicity. Optimizing R.I.T. with [{sup 90}Y] Zevalin will require its use as part of first-line therapy and implementation of patient-specific dosimetry methods in clinical trials. Objectives and methods: we have consecutively studied 2 new modalities of using Zevalin in first line therapy of F.L.. First, we conducted an international, randomized, phase 3 trial to evaluate the efficacy and safety of consolidation with Zevalin(15 MBq/Kg) in patients with advanced-stage F.L. achieving at least a partial response after induction immuno chemotherapy. A second approach consisted of evaluating a fractionated schedule with 2 doses of Zevalin (11.1 MBq/kg each), 9 to 13 weeks apart, as front line therapy in F.L. patients with high tumor burden. As part of this second approach, we designed a refined imaging-based (planar and 3-dimensional) dosimetry protocol to improve prediction of dose efficacy and toxicity after each dose of zevalin. Data acquisition was performed in 3 centers (Lille, Nantes and Manchester) while data treatment and specific dose calculations for major organ, tumor masses and bone marrow were centralized. Conclusion: Consolidation of first remission with {sup 90}Y-ibritumomab tiuxetan in advanced-stage follicular lymphoma is highly effective with no unexpected toxicities, prolonging P.F.S. by 2 years and resulting in high P.R.-to-C.R. conversion rates regardless of type of first-line induction treatment. Preliminary data show the feasibility of front line fractionated R.I.T. with Zevalin in patient with high tumor burden and of implementing a standardized refined data acquisition/treatment protocol for imaging-based dosimetry in the multicenter setting. Dosimetry results obtained for 6 patients who underwent patient-specific quantitative planar imaging after both Zevalin fractions will be presented. (author)

  14. Quebec's energy sector : context, issues and questions for a Quebec energy policy based on sustainable development and energy efficiency : memoire submitted by Vivre en Ville to the Quebec Commission of Economy and Labour; Le secteur energetique au Quebec : contexte, enjeux et questionnements pour une politique energetique quebecoise basee sur le developpement durable et l'efficacite energetique : memoire depose par Vivre en Ville au Quebec Commission de l'economie et du travail

    Energy Technology Data Exchange (ETDEWEB)

    Jampierre, V.; Vaillancourt, J.; Wright-Larin, I. [Vivre en Ville, Montreal, PQ (Canada)

    2005-01-11

    Vivre en Ville is a group of 225 activists from Quebec's health, environment, transportation and education sectors that promote sustainable living in the urban areas of the province. Their recommendations to save energy are based on principles of energy efficiency and combining resources to promote the use of common transportation corridors, diversified urban living and the protection and renovation of heritage sites. In addition to promoting the creation of parks and green spaces in urban areas, the group encourages residents to engage in municipal affairs by demanding solutions to transportation problems. Among their recommendations are a moratorium on the construction of new highways; upgrade existing mass transit systems to minimize personal vehicle use; increase funding for public transport; promote light rail transit to suburban areas; and devote special road lanes to collective transport such as taxis, buses and car pools. Other recommendations include the creation of more bicycle paths and centres that offer bikers shower and locker facilities. The group also believes that companies with more than 30 employees should be required to have transportation policies for its employees, such as organized car pools. Vivre en Quebec claims that too much energy has already been wasted and more action should be taken to implement these recommendations. tabs.

  15. MR tomography of bone marrow changes after high-dose chemotherapy and autologous peripheral stem cell transplantation

    International Nuclear Information System (INIS)

    Purpose: Evaluation of MR standard imaging and short time inversion recovery (STIR) imaging to assess changes in red bone marrow cellularity after high-dose chemotherapy (HDC) and peripheral blood stem cells transplantation (PBSCT). Results: STIR sequences demonstrated marked changes in signal intensity not only until the aplasia occurred but also during bone marrow repopulation. An increased signal intensity was observed after HDC in 13/15 patients (87%), followed by a decrease in signal intensity immediately after aplasia in 14/15 patients (93%). Signal intensity further changed parallel to marrow engraftment in 11/15 patients (73%). T2-TSE only showed clear changes during repopulation in 8/15 patients (53%). The individual course of the signal in T1-TSE was markedly inhomogeneous. Conclusions: STIR sequences show bone marrow edema during aplasia and marrow cellularity during reconstitution and are suitable for characterisation of red bone marrow after HDC and autologous PBSCT. (orig.)

  16. Narrow, duplicated internal auditory canal

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, T. [Servico de Neurorradiologia, Hospital Garcia de Orta, Avenida Torrado da Silva, 2801-951, Almada (Portugal); Shayestehfar, B. [Department of Radiology, UCLA Oliveview School of Medicine, Los Angeles, California (United States); Lufkin, R. [Department of Radiology, UCLA School of Medicine, Los Angeles, California (United States)

    2003-05-01

    A narrow internal auditory canal (IAC) constitutes a relative contraindication to cochlear implantation because it is associated with aplasia or hypoplasia of the vestibulocochlear nerve or its cochlear branch. We report an unusual case of a narrow, duplicated IAC, divided by a bony septum into a superior relatively large portion and an inferior stenotic portion, in which we could identify only the facial nerve. This case adds support to the association between a narrow IAC and aplasia or hypoplasia of the vestibulocochlear nerve. The normal facial nerve argues against the hypothesis that the narrow IAC is the result of a primary bony defect which inhibits the growth of the vestibulocochlear nerve. (orig.)

  17. Radiographically visualized skeletal changes associated with mucopolysaccharidosis VI in cats

    International Nuclear Information System (INIS)

    The radiographic skeletal form and structure of all cats with mucopolysaccharidosis VI is described. Common manifestations included epiphyseal dysplasia, generalized osteoporosis, abnormal nasal turbinate development, his subluxation, impaired development of skeletal growth, pectus excavatum, hyoid hypoplasia, aplasia, hypoplasia and fragmentation or abnormal ossification of the dens, and aplasia or hypoplasia of frontal and sphenoid sinuses. The skeletal measurements of two affected cats were compared with those of normal, sex-matched littermates, and the measurements of two affected female cats were compared with those of a normal male littermate

  18. Le candidat vaccin SPf66 contre Plasmodium falciparum : mythe ou réalité ?

    OpenAIRE

    Robert, F; Gazin, Pierre

    1996-01-01

    Le candidat vaccin SPf66 contre #Plasmodium falciparum$ n'a jusqu'à présent pas fait la preuve de son efficacité. Il est cependant une voie de recherche intéressante méritant d'être approfondie. (Résumé d'auteur)

  19. Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

    Science.gov (United States)

    2005-06-23

    Purpura, Schoenlein-Henoch; Graft Versus Host Disease; Anemia, Hemolytic, Autoimmune; Rheumatoid Arthritis; Churg-Strauss Syndrome; Hypersensitivity Vasculitis; Wegener's Granulomatosis; Systemic Lupus Erythematosus; Giant Cell Arteritis; Pure Red Cell Aplasia; Juvenile Rheumatoid Arthritis; Polyarteritis Nodosa; Autoimmune Thrombocytopenic Purpura; Takayasu Arteritis

  20. Genitourinary dysplasia in a cat

    International Nuclear Information System (INIS)

    A six-month-old kitten had congenital urethral sphincter mechanism incompetence due to urethral hypoplasia and associated uterine hypoplasia and vaginal aplasia. Diagnosis was based on radiographic examination, surgical exploration and histological examination of the lower urinary tract. Surgical correction resulted in a marked clinical improvement. The cat became fully continent following treatment with phenylpropanolamine

  1. Mutations in the human TBX4 gene cause small patella syndrome.

    NARCIS (Netherlands)

    Bongers, M.H.F.; Duijf, P.H.; Beersum, S.E.C. van; Schoots, J.; Kampen, A. van; Burckhardt, A.; Hamel, B.C.J.; Losan, F.; Hoefsloot, L.H.; Yntema, H.G.; Knoers, N.V.A.M.; Bokhoven, J.H.L.M. van

    2004-01-01

    Small patella syndrome (SPS) is an autosomal-dominant skeletal dysplasia characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami. We identified an SPS critical region of 5.6 cM on chromosome 17q22

  2. How bio-questionable are the different recombinant human erythropoietin copy products in Thailand?

    NARCIS (Netherlands)

    Halim, Liem Andhyk; Brinks, Vera; Jiskoot, Wim; Romeijn, Stefan; Praditpornsilpa, Kearkiat; Assawamakin, Anunchai; Schellekens, Huub

    2014-01-01

    PURPOSE: The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market. This study aims to assess the quality of

  3. Tracheobronchial Branching Anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Min Ji; Kim, Young Tong; Jou, Sung Shick [Soonchunhyang University, Cheonan Hospital, Cheonan (Korea, Republic of); Park, A Young [Soonchunhyang University College of Medicine, Asan (Korea, Republic of)

    2010-04-15

    There are various congenital anomalies with respect to the number, length, diameter, and location of tracheobronchial branching patterns. The tracheobronchial anomalies are classified into two groups. The first one, anomalies of division, includes tracheal bronchus, cardiac bronchus, tracheal diverticulum, pulmonary isomerism, and minor variations. The second one, dysmorphic lung, includes lung agenesis-hypoplasia complex and lobar agenesis-aplasia complex

  4. Maxillary sinus agenesis - report of two cases; Agenesia do seio maxilar - relato de dois casos

    Energy Technology Data Exchange (ETDEWEB)

    Pierre, Jorge Henrique Arraes de Alencar; Santana, Expedito Araujo

    2000-04-01

    Agenesis or aplasia of the maxillary sinuses is an extremely rare condition, and only eight cases have been reported in the world medical literature. These malformations may arise as a result of developmental defects. Two cases of unilateral agenesis of the maxillary sinus are presented and the radiological abnormalities and the embryology are discussed. The literature is also reviewed. (author)

  5. Exencephaly in araucana chickens and silkie bantams.

    Science.gov (United States)

    Griffiths, G L; Softly, A

    1985-01-01

    Exencephaly and hydranencephaly were diagnosed in two 6-week-old araucana chickens (Gallus domesticus) and one adult silkie bantam (Gallus domesticus). The chickens were presented with large, subcutaneous, cranial soft-tissue masses and exhibited neurological signs. There was partial aplasia of the frontal bones, resulting in herniation of the cerebral hemispheres. PMID:4026741

  6. Cerebellar dermoid tumor and occipital meningocele in a monozygotic twin : clues to the embryogenesis of craniospinal dysraphism

    NARCIS (Netherlands)

    Groen, R J; van Ouwerkerk, W J

    1995-01-01

    A case of monochorionic/monoamnionic twin with discordant occipital developmental malformations is presented. One female twin appeared to have an occipital meningocele with cerebellar aplasia and died immediately after birth. The other twin presented with signs and symptoms of raised intracranial pr

  7. Birth defects after early pregnancy use of antithyroid drugs

    DEFF Research Database (Denmark)

    Andersen, Stine Linding; Olsen, Jørn; Wu, Chunsen;

    2013-01-01

    OR of birth defects. MMI/CMZ and PTU were associated with urinary system malformation, and PTU with malformations in the face and neck region. Choanal atresia, esophageal atresia, omphalocele, omphalomesenteric duct anomalies, and aplasia cutis were common in MMI/CMZ-exposed children (combined, adjusted...

  8. mRNA translation regulation in Diamond Blackfan Anaemia

    NARCIS (Netherlands)

    R. Horos (Rastislav)

    2013-01-01

    textabstractDiamond Blackfan Anemia is a bone marrow failure syndrome in which patients lack erythroid precursor cells in the bone marrow. Therefore, it is also designated as pure red cell aplasia, as other hematological indices are at normal levels. Around half of DBA patients bear an autosomal dom

  9. Bacterial flora of the sigmoid neovagina

    NARCIS (Netherlands)

    T.A. Toolenaar; I. Freundt (Ingrid); J.H. Wagenvoort; F.J. Huikeshoven (Frans); M. Vogel; J. Jeekel (Hans); A.C. Drogendijk

    1993-01-01

    textabstractThe bacterial microbiota of 15 sigmoid neovaginas, created in patients with congenital vaginal aplasia or male transsexualism, was studied. No specimen was sterile, and only normal inhabitants of the colon were cultured. The total counts of bacteria were low

  10. Mutations in different components of FGF signaling in LADD syndrome.

    NARCIS (Netherlands)

    Rohmann, E.; Brunner, H.G.; Kayserili, H.; Uyguner, O.; Nurnberg, G.; Lew, E.D.; Dobbie, A.; Eswarakumar, V.P.; Uzumcu, A.; Ulubil-Emeroglu, M.; Leroy, J.G.; Li, Y.; Becker, C.; Lehnerdt, K.; Cremers, C.W.R.J.; Yuksel-Apak, M.; Nurnberg, P.; Kubisch, C.; Schlessinger, J.; Bokhoven, J.H.L.M. van; Wollnik, B.

    2006-01-01

    Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3

  11. THE EFFECT OF CYCLOSPORINE ON HEMATOLOGICAL PARAMETERS IN PATIENTS WITH PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA

    NARCIS (Netherlands)

    VANKAMP, H; VANIMHOFF, GW; DEWOLF, JTM; SMIT, JW; HALIE, MR; VELLENGA, E

    1995-01-01

    Four patients with paroxysmal nocturnal haemoglobinuria (PNH) were treated with cyclosporine. The treatment with cyclosporine was based on the hypothesis that immune-mediated bone-marrow damage is the common pathogenetic mechanism of aplasia and PNH, with lack of GPI-linked ligands for an immune att

  12. Radiologic findings of nail-pateIIa syndrome: case report

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sung Bin [Seoul Regional Military Manpower Office, Seoul (Korea, Republic of); Yoo, Jeong Su [Military Manpower Administration, Daejeon (Korea, Republic of)

    2004-09-01

    Nail-patella syndrome is a rare autosomal dominant pleiotropic disorder characterized by dysplasia of the nails, pateller aplasia or hypoplasia, iliac horns, and dysplasia or dislocation of the elbow. We experienced a case of nail-patella syndrome. NPS is a relatively uncommon disease; however, an understanding of the typical radiologic findings is useful in establishing the diagnosis and guiding the treatment.

  13. Bilateral ectrodactyly and spinal deformation in a mixed-breed dog

    OpenAIRE

    Carvallo, Francisco R.; Domínguez, Antonio S.; Morales, Pamela C.

    2011-01-01

    A 3-year-old, female mixed-breed dog had malformations of both thoracic limbs and the vertebral column. Radiographs of the forelimbs showed bilateral development of 2 digits and aplasia of 3 carpal bones. Kyphosis, scoliosis, and deformed vertebrae were present in the thoracolumbar vertebral column.

  14. Ectrodactyly/split hand feet malformation

    OpenAIRE

    Jindal Geetanjali; Parmar Veena; Gupta Vipul

    2009-01-01

    Split-hand/split-foot malformation is a rare limb malformation with median clefts of the hands and feet and aplasia/hypoplasia of the phalanges, metacarpals and metatarsals. When present as an isolated anomaly, it is usually inherited as an autosomal dominant form. We report a case of autosomal recessive inheritance and discuss the antenatal diagnosis, genetic counseling and treatment for the malformation.

  15. Microphthalmia with linear skin defects syndrome.

    Science.gov (United States)

    García-Rabasco, Ana; De-Unamuno, Blanca; Martínez, Francisco; Febrer-Bosch, Isabel; Alegre-de-Miquel, Víctor

    2013-01-01

    Microphthalmia with linear skin defects (MLS) or microcornea, dermal aplasia and sclerocornea (MIDAS) syndrome is a rare X-linked-dominant disorder. We present a patient with agenesis of corpus callosum, ocular abnormalities, and multiple skin defects. The cytogenetic studies of the MLS critical region (Xp22.2) were normal, but a skewed X-chromosome inactivation pattern (85:15) was observed.

  16. In utero phthalate effects in the female rat: a model for MRKH syndrome##

    Science.gov (United States)

    Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by uterine and vaginal canal aplasia in normal karyotype human females and is a syndrome with poorly defined etiology. Reproductive toxicity of phthalate esters (PEs) occurs in rat offspring exposed in utero, a phen...

  17. In Utero Phthalate Effects in the Female Rat: A Model for MRKH Syndrome

    Science.gov (United States)

    Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by uterine and vaginal canal aplasia in normal karyotype human females and is a syndrome with poorly define etiology. Reproductive toxicity of phthlate esters (PEs) occurs in rat offspring exposed in utero. a phenome...

  18. Thymoma associated with severe diarrhoea and anaemia

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ About 40% of patients with thymoma have one or more paraneoplastic syndromes, including myasthenia gravis, pure red cell aplasia (PRCA) or hypogammaglobulinaemia, but Good syndrome occurs in only 5% of these conditions. To our knowledge, only 11 patients (including our cases) of thymoma accompanied with PRCA and Good syndrome have been reported,1 however, no such case was reported in China before 2000.

  19. Macro economic model in agriculture domain for the analysis of the climatic change impact and policies effects in term of efficiency and equity. Short version of the final report at the GICC, february 2002; Modele macro-economique a dominante agricole pour l'analyse de l'impact du changement climatique et des effets des politiques en terme d'efficacite et d'equite. Version abregee du rapport de fin d'etude au GICC, fevrier 2002

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, F.; Piketty, M.G.; Boussard, J.M

    2002-02-15

    The aim of the study is the determination of a detailed model of the world economy, allowing the simulation of the effect of numerous economic policies, especially those which are involved at a world scale to avoid the greenhouse effect gases emissions. This model is based on the previous model, as the GTAP from which the data are used. (A.L.B.)

  20. Air quality. How to give it back its original purity? The proliferation of air cleansers. Filters must be changed regularly. Measurement of the filtering efficiency of air treatment systems. The air treatment plants on the way of certification. Essential oils in a high building; Qualite de l'air. Comment lui rendre sa purete originelle? La proliferation des purificateurs d'air. Il faut changer les filtres regulierement. Mesure de l'efficacite de filtration des systemes de traitement d'air. Les centrales de traitement d'air sur la voie de la certification. Des huiles essentielles dans un immeuble de grande hauteur

    Energy Technology Data Exchange (ETDEWEB)

    Grumel, N.

    2000-07-01

    Outside air is polluted while the ambient indoor air is saturated with microorganisms. Inside buildings, the aeraulic networks are the link between both environments and the privileged place to clean the air using filtering systems. However, the notion of air quality is still badly perceived by owners, in particular in tertiary buildings. In France, efforts have to be made on the maintenance of aeraulic networks by hygiene specialists. Air quality inside buildings must be taken into consideration using communication and regulations. This dossier takes stock of the problem of air quality and of the available means to ensure a good air quality inside residential and tertiary buildings. The maintenance of air filters in one of the key points. It should be integrated in the general maintenance concept of buildings. The dossier includes a study of the in-situ measurement of the filtering efficiency of air treatment systems. This method is described in the Eurovent recommendation 4/10 of 1996. It has been experimented by the French technical centre of aeraulic and thermal industries (Cetiat) and the results are reported in the study. The performances of air treatment plants are now certified by Eurovent. This European organization has defined a program of tests which is conformable with the European EN 1886 and EN 13053 European standards. Finally, a new protocol of air decontamination based on the micronizing of essential oils in the aeraulic network of a 29 floors building is presented. (J.S.)

  1. [Adapted Physical Activity for patients with chronic diseases in a therapeutic community].

    Science.gov (United States)

    Bouricha, Rémy; Thöni, Gilles; Raffard, Laurence; Cochet, Laurence; Saucourt, Vincent; Tirode, Véronique

    2015-01-01

    The French therapeutic communities ("Appartements de Coordination Therapeutique (ACT)") are mostly members of the "National Federation of Accommodation for HIV+ and other chronic diseases. They provide accommodation for people living with chronic conditions (HIV hepatitis, cancers...) and in a situation of high psychosocial frailty. As a result of their coordinated multidisciplinary intervention, these structures provide the required support to access health care and facilitate social inclusion. They are designed to provide an appropriate response to people with cumulative medical and social conditions (chronic diseases, precariousness, addictions and other comorbidities). Our innovative local experiment integrates Adapted Physical Activities (APA) into the global medical and social follow-up, in line with the patient's individual health care project. The characteristics of each APA project (nature of the activities proposed, intensity, duration, frequency, individual vs. team activity and accompanying methods) are defined on an individual basis, according to the user's motivations and inputs from the support team (medical, psychological and social coordination). The follow-up ensured by our APA professionals allows the residents to participate in a regular and attractive physical activity and could contribute to their social inclusion. The multidisciplinary approach proposed by ACTs determines the beneficial effects observed in such vulnerable patients. PMID:26168635

  2. Test des photomultiplicateurs en silicium couplés à un scintillateur plastique pour la nouvelle Tape Station

    CERN Document Server

    sekal, Smain

    2014-01-01

    L’une des parties essentielles de la l’installation ISOLDE est la tape Station (contrôleur de bandes), qui permet la vérification de la qualité du faisceau délivré aux expériences. On prévoit à ISOLDE de remplacer l’ancienne Tape Station, par une nouvelle Tape station; et l’un des paramètres essentiels pour la performance de la tape Station est l’efficacité de détection. Le but de ce travail est de vérifier l’efficacité des détecteurs de particules bêta, composés par l’association des photomultiplicateurs en Silicium à un scintillateur plastique pour differentes distances.

  3. Etude et mise au point d'une cellule à électrodes poreuses pour la récupération d'ions métalliques en solution/study of an electrochemical cell with porous electrodes for an environmental application

    OpenAIRE

    Vande Vyver, Olivier

    2008-01-01

    Les procédés électrochimiques présentent beaucoup d’avantages dans le domaine du traitement et de la récupération de matière d’effluents industriels. Cependant, dans le cas de solutions diluées en ions métalliques, les électrodes classiques sont fortement limitées par leur efficacité ainsi que par leur taille. Dès lors, les électrodes poreuses, de par leur surface spécifique importante et de par leur structure particulière qui améliore le transport de matière et donc l’efficacité de l’électro...

  4. Maladies telluriques : Les champignons n'auront pas le dernier mot

    OpenAIRE

    Bressoud, Frederique

    2009-01-01

    Des systèmes de culture salade-tomate intensifs ont été mis au banc d'essai afin de tester sur le long terme les effets de la solarisation et des engrais verts en alternative aux désinfections chimiques de sol. Des facteurs favorisant les maladies telluriques et l'efficacité des techniques de remédiation ont pu être mis en évidence.

  5. Place de la physiothérapie dans la prise en charge de la maladie de Legg-Perthes-Calve: analyse critique de la littérature : travail de Bachelor

    OpenAIRE

    Zimmermann, Deborah; Leperlier, Laura; Bürge, Elisabeth

    2013-01-01

    La maladie de Legg-Perthes-Calvé (LPC) occupe en fréquence la deuxième place des altérations orthopédiques pédiatriques. Le principal risque à long terme est la coxarthrose précoce. Le but principal de cette revue est d’évaluer l’efficacité de la physiothérapie dans le traitement de la maladie de LPC.

  6. Prevalence and patient characteristics of Mayer-Rokitansky-Küster-Hauser syndrome

    DEFF Research Database (Denmark)

    Herlin, Morten; Bjørn, Anne-Mette Bay; Rasmussen, Maria;

    2016-01-01

    to be around 1 in 4000-5000 females. However, population-based prevalence studies of MRKH syndrome are sparse. Moreover, population-based data on patient characteristics are lacking. STUDY DESIGN, SIZE, DURATION: This retrospective cohort study used the Danish National Patient Registry (DNPR) to identify...... a nationwide population-based cohort of patients with MRKH syndrome. Subsequently, patients were linked to the Danish Cytogenetic Central Registry (DCCR) and patient medical records in order to validate the diagnoses. PARTICIPANTS/MATERIALS, SETTING, METHODS: Hospitalizations and outpatient visits from 1994...... MRKH syndrome/Müllerian duct aplasia, Renal aplasia, and Cervicothoracic Somite dysplasia association were present in 56.5% and 43.5% of the patients, respectively. Kidney malformations were the most prevalent extragenital malformations, described in 38 of 111 patients (34.2%). However, in 57 patients...

  7. Cochlear implant: what the radiologist should know

    Directory of Open Access Journals (Sweden)

    Natalia Delage Gomes

    2013-06-01

    Full Text Available Cochlear implant is the method of choice in the treatment of deep sensorineural hypoacusis, particularly in patients where conventional amplification devices do not imply noticeable clinical improvement. Imaging findings are crucial in the indication or contraindication for such surgical procedure. In the assessment of the temporal bone, radiologists should be familiar with relative or absolute contraindication factors, as well as with factors that might significantly complicate the implantation. Some criteria such as cochlear nerve aplasia, labyrinthine and/or cochlear aplasia are still considered as absolute contraindications, in spite of studies bringing such criteria into question. Cochlear dysplasias constitute relative contraindications, among them labyrinthitis ossificans is highlighted. Other alterations may be mentioned as complicating agents in the temporal bone assessment, namely, hypoplasia of the mastoid process, aberrant facial nerve, otomastoiditis, otosclerosis, dehiscent jugular bulb, enlarged endolymphatic duct and sac. The experienced radiologist assumes an important role in the evaluation of this condition.

  8. Cleidocranial dysplasia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Duk; Lee, Chang Yul; You, Choong Hyun [Chosun University College of Medicine, Gwangju (Korea, Republic of)

    2004-03-15

    Cleidocranial dysplasia is a rare and autosomal dominant disorder characterized by aplasia or hypoplasia of the clavicles, an open fontanelle, dental abnormalities, and short stature. A 17-year-old female who presented with short stature and subsequent delay in eruption of permanent teeth is described. she showed the abnormal hypermobility of the shoulder, ocular hypertelorism and concave nasal bridge. Radiographs revealed the underdeveloped maxilla, defect of the cranium in the fontanelle region, and aplasia of the clavicles. Characteristically, panoramic view revealed near parallel-sided borders of the ascending ramus and downward curvature of the zygomatic arch with hypoplasia. The prolonged retention of deciduous teeth with delayed eruption of permanent teeth and multiple embedded supernumerary teeth were striking. Radiographic and clinical investigations revealed Cleidocranial dysplasia.

  9. Cretinism revisited

    Directory of Open Access Journals (Sweden)

    Ankit Srivastav

    2012-01-01

    Full Text Available Objective: Cretinism is a condition of severely stunted physical and mental growth due to untreated congenital hypothyroidism. It has been largely eliminated in the developed world, though we still continue to see cases in India. Case Report: A 22-year-old male was brought to our Endocrine clinic by his brother due to his "not growing up." The patient was 83 cm in height (SDS - 16.98 and weighed 13.9 kg (150 IU/ml, free T4 and T3 below the assay range. Ultrasound of neck showed absent thyroid tissue in neck. Iodine-131 uptake scan was consistent with thyroid aplasia. Diagnosis was myxematous cretinism due to thyroid aplasia was made, and patient was started on thyroxine supplementation. Conclusion: This case represents the most severe form of untreated congenital hypothyroidism presenting as severely stunted physical and mental growth with delayed bone and sexual maturation.

  10. Cochlear implant: what the radiologist should know; Implante coclear: o que o radiologista precisa saber

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Natalia Delage; Couto, Caroline Laurita Batista; Gaiotti, Juliana Oggioni; Costa, Ana Maria Doffemond; Ribeiro, Marcelo Almeida; Diniz, Renata Lopes Furletti Caldeira, E-mail: nataliadelagegomes@gmail.com [Hospital Mater Dei, Belo Horizonte, MG (Brazil). Unidade de Radiologia e Diagnostico por Imagem

    2013-05-15

    Cochlear implant is the method of choice in the treatment of deep sensorineural hypoacusis, particularly in patients where conventional amplification devices do not imply noticeable clinical improvement. Imaging findings are crucial in the indication or contraindication for such surgical procedure. In the assessment of the temporal bone, radiologists should be familiar with relative or absolute contraindication factors, as well as with factors that might significantly complicate the implantation. Some criteria such as cochlear nerve aplasia, labyrinthine and/or cochlear aplasia are still considered as absolute contraindications, in spite of studies bringing such criteria into question. Cochlear dysplasias constitute relative contraindications, among them labyrinthitis ossificans is highlighted. Other alterations may be mentioned as complicating agents in the temporal bone assessment, namely, hypoplasia of the mastoid process, aberrant facial nerve, otomastoiditis, otosclerosis, dehiscent jugular bulb, enlarged endolymphatic duct and sac. The experienced radiologist assumes an important role in the evaluation of this condition. (author)

  11. Chronic meningitis and central nervous system vasculopathy related to Epstein Barr virus

    Directory of Open Access Journals (Sweden)

    Anil Kumar B Patil

    2012-01-01

    Full Text Available Chronic active Epstein Barr virus (EBV infection causes a wide spectrum of manifestation, due to meningeal, parenchymal and vascular involvement. An 11-year-old boy presented with chronic headache, fever and seizures of 18 months duration. His magnetic resonance imaging Brain showed fusiform aneurysmal dilatations of arteries of both the anterior and posterior cerebral circulation. Cerebrospinal fluid (CSF showed persistent lymphocytic pleocytosis, raised proteins and low sugar with positive polymerase chain reaction for EBV. He later developed pancytopenia due to bone marrow aplasia, with secondary infection and expired. From clinical, imaging and CSF findings, he had chronic lymphocytic meningitis with vasculopathy, which was isolated to the central nervous system. He later had marrow aplasia probably due to X-linked lymphoproliferative disorder related to EBV infection. Vasculopathy, especially diffuse fusiform aneurysmal dilatation associated with chronic EBV infection, is rare, but has been described, similar to our case report.

  12. Quantitative analysis of human herpesvirus-6 genome in blood and bone marrow samples from Tunisian patients with acute leukemia: a follow-up study

    OpenAIRE

    Faten, Nefzi; Agnès, Gautheret-Dejean; Nadia, Ben Fredj; Nabil, Abid Ben Salem; Monia, Zaier; Abderrahim, Khelif; Henri, Agut; Salma, Feki; Mahjoub, Aouni

    2012-01-01

    Background Infectious etiology in lymphoproliferative diseases has always been suspected. The pathogenic roles of human herpesvirus-6 (HHV-6) in acute leukemia have been of great interest. Discordant results to establish a link between HHV-6 activation and the genesis of acute leukemia have been observed. The objective of this study was to evaluate a possible association between HHV-6 infection and acute leukemia in children and adults, with a longitudinal follow-up at diagnosis, aplasia, rem...

  13. Radiographic findings in the nail-patella syndrome

    OpenAIRE

    West, James A.; Louis, Thomas H.

    2015-01-01

    Nail-patella syndrome is a rare disorder characterized classically by the tetrad of nail hypoplasia or aplasia, aplastic or hypoplastic patellae, elbow dysplasia, and the presence of iliac horns. Iliac horns are considered pathognomonic, and the presence of hypoplastic or aplastic patellae in conjunction with nail abnormalities is a cardinal feature of diagnosis. Elbow dysplasia is present in most cases and can exhibit features typical of the syndrome. Herein we present the radiographic findi...

  14. Parvovirus-induced dyserythropoeisis in a child

    Directory of Open Access Journals (Sweden)

    Jain Deepali

    2008-07-01

    Full Text Available Most persons with parvovirus B19 infection are asymptomatic or exhibit mild, nonspecific, cold-like symptoms. However, hematologic problems associated with the infection include transient aplastic crisis, chronic red cell aplasia, mild neutropenia and thrombocytopenia. A rare hematologic manifestation is in the form of dyserythropoeisis. Herein, we present the case of a 9-year-old female with severe dyserythropoeisis associated with parvovirus infection.

  15. Proboscis Lateralis of Nose—A Case Report

    OpenAIRE

    Magadum, Sunil Bajarang; Khairnar, Prashant; Hirugade, Shivprasad; Kassa, Vijay

    2011-01-01

    Lateral proboscis is a rare craniofacial malformation characterized by a rudimentary tubular, nose-like structure located off-center from the vertical midline of the face, and occur in association with a wide spectrum of other anomalies, including heminasal aplasia spectrum,mental retardation, callosal agenesis, heminasal hypoplasia, microphthalmia, and atypical clefting syndrome. Evaluation of a patient should include CT scan examination to look for growth of facial and skull bones. Reconstr...

  16. In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature

    OpenAIRE

    Esther N Pesciotta; Ho-Sun Lam; Andrew Kossenkov; Jingping Ge; Showe, Louise C.; Mason, Philip J.; Monica Bessler; Speicher, David W.

    2015-01-01

    Diamond Blackfan Anemia (DBA) is a rare, congenital erythrocyte aplasia that is usually caused by haploinsufficiency of ribosomal proteins due to diverse mutations in one of several ribosomal genes. A striking feature of this disease is that a range of different mutations in ribosomal proteins results in similar disease phenotypes primarily characterized by erythrocyte abnormalities and macrocytic anemia, while most other cell types in the body are minimally affected. Previously, we analyzed ...

  17. Anaesthetic Management for Cataract Surgery in VACTERL Syndrome Case Report

    Directory of Open Access Journals (Sweden)

    Sonal S Khatavkar

    2009-01-01

    Full Text Available Eight year old girl, weighing 14 kg with VACTERL syndrome V: Vertebral anomalies, A: Anal malformation, C: Cardiovascular defect, TE: Tracheal and esophageal malformation, R:Renal agenesis, L: Limb anomalies., underwent cataract surgery under general anaesthesia. She had multiple congenital anomalies like esophageal atresia, imperfo-rate anus (corrected, single kidney& radial aplasia. Anticipating problems of gastro-esophageal reflux& chronic renal failure, successful management was done.

  18. PCI-32765, the First BTK (Bruton’s Tyrosine Kinase) Inhibitor in Clinical Trials

    OpenAIRE

    Brown, Jennifer R

    2013-01-01

    Ibrutinib is a potent covalent kinase inhibitor that targets BTK. BTK, or Bruton’s tyrosine kinase, is an obvious target for therapy of B cell diseases because inactivating mutations lead to B cell aplasia in humans and the disease X-linked agammaglobulinemia. Ibrutinib has modest cytotoxicity against CLL cells in vitro but also blocks trophic stimuli from the microenvironment. As with other inhibitors of the BCR pathway, ibrutinib causes rapid nodal reduction and response associated with rap...

  19. Conservative Treatment of a Patient with Epidermolysis Bullosa Presenting as Bart Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Samet Vasfi Kuvat

    2010-01-01

    Full Text Available We presented a case of a newborn male with aplasia cutis congenita on the lower limb. The case was treated with conservative method. As for the conservative treatment, daily hydrodebridement with 1/200 diluted povidone-iodine and serum physiologic was performed, followed by closure of the wound with a dexpanthenol + chlorhexidine + fusidic acid-impregnated sterile gauze bandage. the followup that occured after three weeks, the wound was completely epithelialized, but a hypopigmented scar remained in the limb.

  20. BIZARRE CASE OF POLYDACTYLY WITH RIGHT MIRROR FOOT

    Directory of Open Access Journals (Sweden)

    Saif Omar

    2014-06-01

    Full Text Available Mirror foot, a form of polydactyly, is a rare congenital anomaly. In this form of congenital anomaly, there are several additional digits with accessory tarsal bones. It may be associated with fibular dimelia, tibial aplasia and tibial dysplasia. Cause of such anomaly is not known. On experimental basis it appears to involve ectopic SHH (Sonic hedgehog signaling in the limb bud mesenchyme

  1. Prenatal Diagnosis of Bilateral Ectrodactyly and Radial Agenesis Associated with Trisomy 10 Mosaicism

    OpenAIRE

    Jonathan Lévy; Jean-Marie Jouannic; Julien Saada; Ferdinand Dhombres; Jean-Pierre Siffroi; Marie-France Portnoï

    2013-01-01

    Ectrodactyly or split hand and foot malformations (SHFMs) are rare malformations of the limbs, characterized by median clefts of the hands and feet, syndactyly, and aplasia and/or hypoplasia of the phalanges. They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. Bilateral radial ray defects compris...

  2. Chromosome and p63 Gene Analysis of an Infant with Ectrodactyly–Split Hand and Foot Malformation

    OpenAIRE

    DEMİRHAN, Osman

    2007-01-01

    Aim: Split hand-split foot malformation (SHFM) results from central ray reduction and presents as median clefts of the hands and feet, syndactyly, aplasia or hypoplasia of the phalanges, metacarpals and metatarsals, which are frequently associated with other phenotypic abnormalities. We aimed to investigate the genetic pathway of SHFM in a child. Materials and methods: Cytogenetic and molecular genetic analysis was performed in a 10-day-old boy with split-syndactyly hand and flat-syndactyly...

  3. Three new patients with FATCO: fibular agenesis with ectrodactyly.

    Science.gov (United States)

    Bieganski, Tadeusz; Jamsheer, Aleksander; Sowinska, Anna; Baranska, Dobromila; Niedzielski, Kryspin; Kozlowski, Kazimierz; Czarny-Ratajczak, Malwina

    2012-07-01

    We document three new patients with fibular agenesis, tibial campomelia, and oligosyndactyly (FATCO). Two of these individuals had tetramelic manifestations while the third had bilateral abnormalities of the lower limbs. These patients and others reported as FATCO seem to belong to the phenotype "fibular aplasia with ectrodactyly." Genetic screening for CNVs and mutations in the TP63 and WNT10B genes did not show any genetic abnormalities. © PMID:22628253

  4. MEDICAL MYSTERY: ECTRODACTYLY A CASE REPORT

    OpenAIRE

    Subhra Mandal; Prabir Mandal; Panchanan Kundu

    2015-01-01

    Congenital absence of all or part of one or more fingers or toes is defined as Ectrodactyly. It is the word derived from Greek ektroma meaning “abortion” and dactyly meaning digits. Also called split hand or foot malformation (SHFM), Ectrodactyly is a rare limb malformation with median cleft of hand and foot and aplasia or hypoplasia of the phalanges, metacarpals and metatarsals. Irregular pattern of inheritance exists for ectrodactyly; may be autosomal dominant, autosomal recessive or X link...

  5. Ectrodactyly/split hand feet malformation

    Directory of Open Access Journals (Sweden)

    Jindal Geetanjali

    2009-01-01

    Full Text Available Split-hand/split-foot malformation is a rare limb malformation with median clefts of the hands and feet and aplasia/hypoplasia of the phalanges, metacarpals and metatarsals. When present as an isolated anomaly, it is usually inherited as an autosomal dominant form. We report a case of autosomal recessive inheritance and discuss the antenatal diagnosis, genetic counseling and treatment for the malformation.

  6. Unilateral Ectrodactyly in a Newborn with Trisomy 18 Syndrome: An Unusual Association.

    Science.gov (United States)

    Kislal, Fatih Mehmet; Altuntas, Nilgun; Ozdemir, Osman; Ceylaner, Serdar; Kislal, Mustafa Hayri; Andiran, Nesibe

    2015-08-01

    The case of a newborn male with trisomy 18 syndrome, having bilateral syndactyly, aplasia and hypoplasia of the foot digits, unilateral ectrodactyly of the left foot and a prominently dorsiflexed hallux, clenched hand with overlapping fingers and general hypertonia, is presented. There are only 5 cases of trisomy 18 syndrome associated with ectrodactyly in the literature. We present a case of trisomy 18 syndrome with unilateral ectrodactyly of the left foot, which is an infrequent association. PMID:26305313

  7. Limb mammary syndrome: a new genetic disorder with mammary hypoplasia, ectrodactyly, and other Hand/Foot anomalies maps to human chromosome 3q27.

    OpenAIRE

    Van Bokhoven, H.; Jung, M; Smits, A P; van Beersum, S.; Rüschendorf, F; Van Steensel, M; Veenstra, M; Tuerlings, J.H.; Mariman, E.C.; Brunner, H.G.; Wienker, T. F.; Reis, A.; Ropers, H H; Hamel, B C

    1999-01-01

    We report on a large Dutch family with a syndrome characterized by severe hand and/or foot anomalies, and hypoplasia/aplasia of the mammary gland and nipple. Less frequent findings include lacrimal-duct atresia, nail dysplasia, hypohydrosis, hypodontia, and cleft palate with or without bifid uvula. This combination of symptoms has not been reported previously, although there is overlap with the ulnar mammary syndrome (UMS) and with ectrodactyly, ectodermal dysplasia, and clefting syndrome. Al...

  8. Familial Ectrodactyly Syndrome in a Nigerian Child: A Case Report

    OpenAIRE

    Abdulrasheed Adegboye; Olugbenga Ayodeji Mokuolu; Samuel Kolade Ernest; Omotayo Adesiyun; Adeline Adaje; Sefiyah Yahaya-Kongoila; Muhammed Adeboye; Mathew Durowaye

    2011-01-01

     Ectrodactyly, also known as Split-Hand/Split-Foot Malformation (SHFM) is a rare genetic condition characterized by defects of the central elements of the autopod. It has a prevalence of 1:10,000-1:90,000 worldwide. The X-linked and autosomal dominant types have been described. It can occur as an isolated malformation or in combination with other anomalies, such as tibial aplasia, craniofacial defects, and genitourinary abnormalities. Ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC) ...

  9. Scientific works of research workers of the army health service; Travaux scientifiques des chercheurs du service de sante des armees

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Ten articles about the effects of gamma radiation on human or animal cells are studied here. Regulation of cytokines, effect of interleukin 6, expression of the C-fos protein, interest of the study of a biological check up after an accidental irradiation, interaction and transport of cysteamine( radioprotector), approach of a treatment of radioinduced medullary aplasia, expression of TNF alpha and gelatinase B, are the subjects related here. (N.C.).

  10. A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy

    Directory of Open Access Journals (Sweden)

    Hinkes Bernward

    2012-05-01

    Full Text Available Abstract Background Microdeletions on chromosome 17q12 cause of diverse spectrum of disorders and have only recently been identified as a rare cause of Mayer-Rokitansky-Kuester-Hauser-Syndrome (MRKH, which is characterized by uterus aplasia ± partial/complete vaginal aplasia in females with a regular karyotype. For the first time we report about a patient with a 17q12 microdeletion who is affected by MRKH in combination with a vascular and soft tissue disorder. Repeatedly she suffered from kidney transplant failure caused by consuming membranous nephropathy. Case presentation A 38-year-old female patient had been diagnosed with right kidney aplasia, left kidney dysplasia and significantly impaired renal function during infancy. Aged 16 she had to start hemodialysis. Three years later she received her first kidney transplant. Only then she was diagnosed with MRKH. The kidney transplant was lost due to consuming nephrotic syndrome caused by de novo membranous nephropathy, as was a second kidney transplant years later. In addition, a hyperelasticity syndrome affects the patient with congenital joint laxity, kyphoscoliosis, bilateral hip dysplasia, persistent hypermobility of both elbows, knees and hips. Her clinical picture resembles a combination of traits of a hypermobile and a vascular form of Ehlers-Danlos-Syndrome, but no mutations in the COL3A1 gene was underlying. Instead, array-based comparative genomic hybridisation (CGH detected a heterozygous 1.43 Mb deletion on chromosome 17q12 encompassing the two renal developmental genes HNF1β and LHX1. Conclusions Deletions of HNF1β have recently drawn significant attention in pediatric nephrology as an important cause of prenatally hyperechogenic kidneys, renal aplasia and renal hypodysplasia. In contrast, membranous nephropathy represents an often-unaccounted cause of nephrotic syndrome in the adult population. A causative connection between theses two conditions has never been postulated, but

  11. Scientific works of research workers of the army health service

    International Nuclear Information System (INIS)

    Ten articles about the effects of gamma radiation on human or animal cells are studied here. Regulation of cytokines, effect of interleukin 6, expression of the C-fos protein, interest of the study of a biological check up after an accidental irradiation, interaction and transport of cysteamine( radioprotector), approach of a treatment of radioinduced medullary aplasia, expression of TNF alpha and gelatinase B, are the subjects related here. (N.C.)

  12. The Baller-Gerold syndrome.

    OpenAIRE

    Maldergem, L. van; Verloes, A.; Lejeune, L.; Gillerot, Y.

    1992-01-01

    A case of severe craniosynostosis-radial aplasia (Baller-Gerold) syndrome is described in a newborn male, following a pregnancy complicated by polyhydramnios and intrauterine growth retardation. Death occurred after two hours owing to a prolonged apnoeic spell. Extensive agenesis of the frontal and parietal bones, resulting in a very large fontanelle, in addition to coronal bilateral craniosynostosis was observed at necropsy. There was also bilateral radial agenesis, oligodactyly of the hands...

  13. Congenital deformities and developmental abnormalities of the mandibular condyle in the temporomandibular joint.

    Science.gov (United States)

    Kaneyama, Keiseki; Segami, Natsuki; Hatta, Toshihisa

    2008-09-01

    The temporomandibular joint (TMJ) consists of the mandibular condyle and the articular eminence of the temporal bone. The morphological development of the TMJ during prenatal life lags behind other joints in terms of both the timing of its appearance and its progress. At birth, the joint is still largely underdeveloped. There are many causes of the various growth disturbances and abnormalities of the mandibular condyle and related structures. Growth disturbances in the development of the mandibular condyle may occur in utero late in the first trimester and may result in disorders such as aplasia or hypoplasia of the mandibular condyle. Meanwhile, hyperplasia of the mandibular condyle is not visible at birth and seems to be gradually acquired during growth. In the present review article, the congenital abnormalities of the mandibular condyle are classified morphologically into three major groups and two subgroups from a clinical standpoint: (1) hypoplasia or aplasia of the mandibular condyle, including (i) primary condylar aplasia and hypoplasia, (ii) secondary condylar hypoplasia; (2) hyperplasia; and (3) bifidity. In addition, the molecular-based etiology of anomalies of the mandibular condyle is also discussed. PMID:18778456

  14. Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária

    Directory of Open Access Journals (Sweden)

    R. C. N. Cubel

    1992-10-01

    Full Text Available Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia.

  15. Medical management of accidentally exposed individuals

    International Nuclear Information System (INIS)

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Whilst transfusion and bone marrow transplantation have been used with some success starting with the first treatments of accident victims, other therapeutic strategies are needed. With the development of experimental and clinical haematology, promising new approaches to the treatment of aplasia have appeared. New trends for the treatment of haemopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. Haemopoietic growth factors stimulate the proliferation and/or differentiation of haemopoietic progenitors and, possibly, stem cells. Furthermore, they act on the functions of mature cells. Currently, they have specific uses in haematology related to their role in the regulation of growth and in the differentiation of haemopoietic progenitor cells. Growth factors have already been used for the treatment of accidental radiation induced aplasia and lessons have been learned from their medical management and followup. (author)

  16. Unilateral dysgenesis of the internal carotid artery: spectrum of imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    De Mendonca, J.L.F.; Viana, S.L.; Freitas, F.M.O.; Matos, V.L. [Magnetic Resonance Dept., Clinica Radiologica Vila Rica, Brasilia (Brazil)], E-mail: radiolog@uol.com.br; Viana, M.A.C.B. [Hospital de Base do Distrito Federal, Brasilia (Brazil); Silva, R.F. [Diagnostik, Hospital das Clinicas de Brasilia, Brasilia (Brazil); Quaglia, L.A.N. [Hospital Santa Lucia, Brasilia (Brazil); Guerra, J.G. [Hospital Regional de Taguatinga, Brasilia (Brazil)

    2008-04-15

    Dysgenesis of the internal carotid artery (ICA) is a broad term comprising hypoplasia, aplasia and agenesis of the vessel. It is a rare anomaly, often clinically silent, that can be confidently diagnosed by means of noninvasive imaging methods. After a review of teaching files, 7 patients with unilateral carotid dysgenesis were found, 2 with agenesis of the ICA, 3 with carotid aplasia, and 2 with hypoplasia of the vessel. Computed tomography (CT) and magnetic resonance angiography (MRA) of the brain were performed in all patients, with a complete magnetic resonance of the brain in 3 of them, a CT angiography of the brain in one, and MRA of the cervical arteries in 3. The fetal pattern of arterial circulation was found in 3 patients with agenesis/aplasia of the ICA and the adult pattern was found in 2 patients, being the brain circulation of normal pattern in the patients with hypoplasia of the ICA. Two patients presented signs of reduced flow to the brain hemisphere ipsilateral to the carotid dysgenesis; one of them with an old homolateral brain infarction. Far from being just an anatomic curiosity, the dysgenesis of the ICA may have serious consequences if not recognized prior to endarterectomies, carotid ligation or transsphenoidal surgery. As much as one-third of these patients will have intracranial aneurysms as well. The imaging methods, instead being mutually exclusive, are complementary in the evaluation of carotid dysgenesis. (author)

  17. Unilateral dysgenesis of the internal carotid artery: spectrum of imaging findings

    International Nuclear Information System (INIS)

    Dysgenesis of the internal carotid artery (ICA) is a broad term comprising hypoplasia, aplasia and agenesis of the vessel. It is a rare anomaly, often clinically silent, that can be confidently diagnosed by means of noninvasive imaging methods. After a review of teaching files, 7 patients with unilateral carotid dysgenesis were found, 2 with agenesis of the ICA, 3 with carotid aplasia, and 2 with hypoplasia of the vessel. Computed tomography (CT) and magnetic resonance angiography (MRA) of the brain were performed in all patients, with a complete magnetic resonance of the brain in 3 of them, a CT angiography of the brain in one, and MRA of the cervical arteries in 3. The fetal pattern of arterial circulation was found in 3 patients with agenesis/aplasia of the ICA and the adult pattern was found in 2 patients, being the brain circulation of normal pattern in the patients with hypoplasia of the ICA. Two patients presented signs of reduced flow to the brain hemisphere ipsilateral to the carotid dysgenesis; one of them with an old homolateral brain infarction. Far from being just an anatomic curiosity, the dysgenesis of the ICA may have serious consequences if not recognized prior to endarterectomies, carotid ligation or transsphenoidal surgery. As much as one-third of these patients will have intracranial aneurysms as well. The imaging methods, instead being mutually exclusive, are complementary in the evaluation of carotid dysgenesis. (author)

  18. Clinical and symptomatological study of pigs subjected to a lethal dose of integral gamma irradiation; Etude clinique et symptomatologique chez le porc soumis a une irradiation gamma totale a dose letale

    Energy Technology Data Exchange (ETDEWEB)

    Vaiman, M.; Guenet, J.-L.; Maas, J.; Nizza, P

    1966-05-01

    Results are reported from a clinical and haematological study on a Corsican species of pigs wholly exposed to an approximately lethal dose of {gamma} radiation. The aim of this work was to examine the changes in the irradiation syndrome of irradiation for pigs to make it thus possible to devise further experiments, in particular in the therapeutic field. The dose received was 285 rads (measured as the absorption in the vertical antero-posterior medial plane). Data are presented on cyto-haematological changes in the blood circulating immediately after irradiation, and followed up to death, and changes in the medullary cytology after irradiation. The clinical picture of lethal radiation injury in swine is described. (authors) [French] Les auteurs rapportent les resultats d'une etude clinique et hematologique chez des porcs de race corse irradies in toto a dose sensiblement letale. Le but de cette etude etait de connaitre l'evolution du syndrome aigu d'irradiation chez le porc et de permettre ainsi le developpement d'experimentations ulterieures, en particulier dans le domaine therapeutique. La dose delivree etait de 285 rad (en dose absorbee au niveau du plan median vertical anteroposterieur. L'etude a porte essentiellement: 1. Sur les modifications cyclo-hematologiques du sang circulant immediatement apres l'irradiation, pour les differentes lignees cellulaires; l'evolution de ces modifications a ete notee jusqu'a la mort; 2. Sur les modifications de la cytologie medullaire apres irradiation (evolution du myelogramme et essai d'evaluation de la cellularite de la moelle osseuse);: 3. Sur les signes cliniques, d'ailleurs tres discrets, observes chez les porcs apres irradiation. (auteurs)

  19. Evaluaton de l'éfficacité antimicrobienne (Concentration Mhirnae et Concentration Minimale Bactéricie) de quatre conservateurs

    OpenAIRE

    bensabeur slimane, fatima zohra

    2015-01-01

    Les conservateurs constituent un thème récurrent d'interrogations et de débat Présents dans les aliments, les produits cosmétiques ou les médicaments, h conservateurs sont omniprésents. Ces conservateurs jouent un rôle essentiel dans la conservation des produit cosmétiques en empêchant les proliférations microbiennes. L'objectif de notre étude est d'évaluer l'efficacité antimicrobienne (Concentratio Minimale Inhibitrice et Concentration Minimale Bactéricide) de quatre conser...

  20. Mieux assumer les paradoxes d’une formation professionnelle et universitaire des enseignants d’éducation musicale : analyse de quelques « notions fondamentales » au regard des idéologies de la nature-source

    OpenAIRE

    GUIRARD, laurent

    2011-01-01

    International audience L’éducation musicale souffre d’une difficulté didactique courante mais possiblement aggravée par son statut d’art d’agrément : le manque d’accord entre une pratique de terrain que peut légitimement gouverner un critère d’efficacité relativement autonome (les élèves font ou entendent de la musique et en éprouveraient « simplement du plaisir »), et des outils théoriques épars qui permettraient de comprendre ou d’éclairer cette pratique à partir d’une position d’autorit...

  1. La recherche pour l'innovation ou l'innovation pour la recherche? Le développement du photovoltaïque en Polynésie

    OpenAIRE

    Akrich, Madeleine

    1988-01-01

    National audience A partir d'une étude de cas, l'implantation d'un programme d'électrification photovoltaïque en Polynésie, cet article s'interroge sur rôle de la recherche dans l'innovation industrielle: on montre que, dans ce cas particulier, cela revient à se poser la question de l'efficacité relative des multiples moyens d'accès au "réel" dont disposent les innovateurs pour ajuster la forme de l'objet technique au milieu auquel il est destiné. L'effort de description porte sur la resti...

  2. Les collectivités : une source de déchets organiques et une voie de valorisation de la chaleur pour la méthanisation agricole ?

    Directory of Open Access Journals (Sweden)

    LEVASSEUR, Pascal ; CHARPIOT, Alicia ; LE GUEN, Gaëlle

    2013-10-01

    Full Text Available Un des intérêts de la méthanisation est qu'elle peut participer à un recyclage extrêmement rentable des déchets. De fait, les collectivités ont un rôle à jouer dans ce processus car elles génèrent de nombreux types de déchets. Mais dans quelles mesures leur participation est-elle actuellement intéressante ? La volonté d'aboutir à une plus grande efficacité induit des changements de comportement de la part des foyers et des institutions. Quels sont-ils?

  3. Conduite de la reproduction des mammifères domestiques : présent et futur

    OpenAIRE

    COUROT, M.; Volland-Nail, Patricia

    1991-01-01

    International audience; Les techniques modernes de reproduction appliquées aux mammifères domestiques ont pour but d'accroître l'efficacité de la production de jeunes dans les conditions choisies par les éleveurs. Cette revue présente les différentes techniques disponibles pour atteindre un tel objectif. Pour les mâles, en plus de l'utilisation de semence par insémination artificielle désormais possible chez toutes les espèces domestiques, l'accent est mis sur deux stratégies : d'une part dis...

  4. Synthesis and investigation of new large self-assembled supramolecules as potential electron emitters

    OpenAIRE

    Alameddine, Bassam; Jenny, Titus

    2007-01-01

    La nanotechnologie, domaine de recherche qui couvre plusieurs branches scientifiques en Médecine, Biologie, Physique et Chimie, est en pleine expansion dans les institutions de recherche et suscite un vif intérêt dans l’industrie vu ses prometteuses applications. Ceci est dû à plusieurs raisons, parmi lesquelles, on note le control à une échelle moléculaire ce qui augmente l’efficacité du procédé et diminue le coût en matière première. L’auto-assemblage moléculaire, phénomène qui implique les...

  5. Analyser l'innovation dans un Système agroalimentaire localisé : construction interdisciplinaire en Languedoc

    OpenAIRE

    Touzard, Jean-Marc; Chiffoleau, Yuna; Dreyfus, Fabrice

    2008-01-01

    L'article analyse les processus d'innovation dans les coopératives viticoles du Languedoc en associant trois approches de l'innovation croisant économie et sociologie. L'analyse économique et statistique montre la diversité de combinaisons d'innovations élémentaires et leur efficacité lorsqu'elles couvrent différentes étapes de la production. L'analyse longitudinale de systèmes d'action innovants souligne l'importance des connaissances et relations construites dans des processus soumis à de n...

  6. Pour l'effectivité du droit du travail : quel système d'inspection et quelle indépendance des inspecteurs ?

    OpenAIRE

    Auvergnon, Philippe

    2006-01-01

    L'effectivité du droit du droit du travail est-elle réellement possible dans un système généraliste d'inspection du travail couvrant l'ensemble des secteurs ? Ou plutôt trouve-t-elle sa place dans un système indépendant reposant sur un fondement normatif dans lequel le contrôle s'exerce loin de toute influence extérieure pouvant nuire à la réalité et l'efficacité de la mission fondamentale d'application du droit du travail ?

  7. Une approche comparative de la question de l'effectivité du droit du travail

    OpenAIRE

    Auvergnon, Philippe

    2006-01-01

    La question de l'effectivité du droit du travail n'est pas nouvelle. Toutefois, une approche comparative, à partir de différents systèmes juridiques et de relations professionnelles, permet utilement de la revisiter. Qu'entend-on par effectivité du droit ? Ne confond-on pas aujourd'hui souvent effectivité et efficacité ? Le droit du travail est-il particulièrement exposé à l'ineffectivité du fait des rapports de pouvoir prévalant dans les relations de travail subordonné ? L'analyse des effect...

  8. Le clonage somatique : un état des lieux chez les bovins et les petits ruminants

    OpenAIRE

    Heyman, Yvan; Chavatte-Palmer, Pascale; Vignon, Xavier; Richard, Christophe; Renard, Jean Paul

    2005-01-01

    Parmi les récentes biotechnologies de la reproduction chez les mammifères d’élevage, le clonage par transfert de noyaux somatiques constitue un pas en avant depuis la naissance de la brebis Dolly. Cet article fait le point sur les résultats actuels obtenus dans le monde chez les bovins et les petits ruminants, les limites de la technique et les applications potentielles. L’efficacité globale du clonage (nombre de jeunes nés /nombre d’embryons reconstitués) reste encore faible (≤ 7 %), mais el...

  9. Chapitre V. Moderniser la régie des Contributions indirectes 1959-1962

    OpenAIRE

    2014-01-01

    Ma première mission à la DGI se situe dans les services des contributions indirectes. Robert Blot m’avait fixé un programme précis : moderniser cette vieille administration, sans lui faire perdre les qualités, originales, qui faisaient son efficacité dans la lutte contre la fraude. La régie des Contributions indirectes était une très ancienne administration, attachée à son histoire, et marquée par ses origines. Sous l’Ancien Régime, les aides, impôts de consommation sur divers produits tels q...

  10. Cellules solaires photovoltaïques plastiques enjeux et perspectives

    Science.gov (United States)

    Sicot, L.; Dumarcher, V.; Raimond, P.; Rosilio, C.; Sentein, C.; Fiorini, C.

    2002-04-01

    Après avoir détaillé le fonctionnement d'une cellule photovoltaïque plastique et les paramètres photovoltaïques permettant de caractéiser son efficacité, un état de l'art des technologies de fabrication des cellules est présenté. Des moyens d'amélioration des performances des cellules photovoltaïques organiques sont ensuite illustrés par l'étude de dispositifs développés au Laboratoire Composants Organiques (LCO) du CEA Saclay.

  11. Etude préliminaire de l'influence des disponibilités alimentaires et des activités humaines sur l’utilisation spatiale de l’habitat par les chimpanzés et les bonobos1

    OpenAIRE

    Narat, Victor; Cibot, Marie; Bokika Ngawolo, Jean Christophe; Dumez, Richard; Krief, Sabrina

    2012-01-01

    L’étude des interactions existant entre les populations locales, l’environnement et les grands singes est indispensable pour une meilleure compréhension des capacités d'adaptation des grands singes aux perturbations de l’habitat et pour l’évaluation des menaces spécifiques au contexte local. De telles études peuvent contribuer à améliorer l’efficacité et la durabilité des actions de conservation ainsi que le développement des populations locales. Cette étude préliminaire compare l’influence d...

  12. Comportement alimentaire, quantités ingérées et performances des bovins conduits en groupe

    OpenAIRE

    Ingrand, Stéphane

    2000-01-01

    La hiérarchie sociale et les effets d’entraînement sont deux composantes importantes du comportement social qui influencent fortement le niveau d’ingestion et le comportement alimentaire des bovins conduits en groupe. Cet effet se traduit pour des animaux à besoins nutritionnels élevés (animaux laitiers ou en croissance) par des niveaux d’ingestion supérieurs et une moindre efficacité alimentaire par rapport à des situations où les animaux sont alimentés individuellement (à l’attache ou en bo...

  13. Des rites pour vivre en fin de vie: enjeux pour le soin et les soins palliatifs

    OpenAIRE

    Jacquemin, Dominique

    2011-01-01

    C'est la présence du professionnel -sans oublier ici les accompagnants bénévoles- qui permettra au malade de vivre le soin comme rite, c’est-à-dire passage où des dimensions de l’existence habituellement non dites et vécues en opposition -vie/mort, efficacité/lâché prise, objectivation/subjectivation, bonheur/malheur- puissent se vivre et donner au soin sa dimension ultime, restant dans sa pleine dimension médicale.

  14. Consequences of the presence of politicians or employees in the board of directors on the efficiency of firms

    OpenAIRE

    Lyon-Caen, Clément

    2015-01-01

    Cette thèse étudie l’impact de la composition du conseil d’administration sur la performance financière d’une entreprise. Elle est composée de trois chapitres. Dans le premier chapitre, nous effectuons une revue de la littérature sur les conseils d’administration. Nous pointons l’évolution de la gouvernance des entreprises au cours des dernières décennies, et montrons en quoi l’efficacité des conseils d’administration est devenue un sujet majeur de ce champ de recherche et une préoccupation i...

  15. Fusions et acquisitions et richesse des actionnaires : le cas des banques européennes

    OpenAIRE

    Diaw, Abdourahmane

    2012-01-01

    Cette thèse porte sur le lien entre fusions et acquisitions et création de valeur actionnariale. La problématique consiste à analyser ce paradoxe qui est le recours des banques aux fusions et acquisitions en dépit des résultats des recherches scientifiques qui en démontrent le peu d’efficacité en termes de rentabilité actionnariale. De prime abord nous procédons à une analyse théorique des fusions et acquisitions bancaires en insistant sur des aspects particuliers comme l’évolution du phénomè...

  16. Effectiveness of interventions targeting frequent users of emergency departments: a systematic review

    OpenAIRE

    Althaus F.

    2012-01-01

    L'article publié de le cadre de cette thèse est intitulé "Effectiveness of interventions targeting frequent users of emergency departments: A systematic review." Il a été publié par les "Annals of Emergency Medicine (AEM)" en juillet 2011. Le titre en français pourrait être: "Efficacité des interventions ciblant les utilisateurs fréquents des services d'urgence: Une revue systématique." Le titre du journal américain pourrait être: "Annales de Médecine d'Urgence". Il s'agit du journal du "Coll...

  17. Etude simulée d'un système de dessalement d'eau de mer et de production de froid par thermofrigopompe couplée à des panneaux solaires

    OpenAIRE

    Byrne, Paul; Miriel, Jacques; Serres, Laurent; Ghoubali, Redouane

    2012-01-01

    International audience; L'accès à l'eau potable est un des enjeux majeurs des prochaines decennies. La recherche sur les technologies de dessalement à forte efficacité énergétique doit donc être particulièrement active. Cet article présente un système de thermofrigopompe produisant simultanément du froid pour une enceinte réfrigérée et de la chaleur utilisée par une unité de dessalement par distillation membranaire. L'énergie électrique est fournie par des panneaux photovoltaïques pour une po...

  18. Musique et pouvoirs

    OpenAIRE

    Aubert, Laurent; Bois, Pierre; Borel, François; Brandily, Monique; CAUFRIEZ, Anne; Cheyronnaud, Jacques; Crowe, Peter; Desjacques, Alain; During, Jean; Erguner, Ahmed Kudsi; Helffer, Mireille; Howard, Keith; Leymarie, Isabelle; Lortat-Jacob, Bernard; Mesnil, Marianne

    2015-01-01

    Selon une croyance quasi universelle, certaines musiques sont investies de pouvoirs, d'où leur efficacité dans des rites permettant à l'individu ou à la collectivité de communiquer avec le monde invisible. D'autres musiques sont porteuses de messages subliminaux et d'effets, dans la mesure où leurs formes sont adaptées à leur finalité. Ainsi, l'usage de la musique à des fins politiques est fréquent, en tant que signe du pouvoir ou que de véhicule de sa propagation. Cette relation peut d'aille...

  19. L'acide linoléique conjugué en nutrition porcine

    OpenAIRE

    C. Corino; G. Pastorelli; Douard, Véronique; Rossi, R; MUSELLA, M.; Mourot, Jacques

    2006-01-01

    Les CLA ont plusieurs effets biologiques intéressants vis-à-vis de la santé : ils ont une propriété anticarcinogène, une activité anti-athérosclérose et antioxydante. Ils diminuent l’obésité et apparaissent comme un facteur capable de stimuler la réponse immunitaire. En nutrition porcine, l’influence sur les performances de croissance est limitée et on peut observer seulement un faible effet positif sur l’efficacité alimentaire. La composition corporelle et les paramètres de la qualité de la ...

  20. Le marketing responsable, un outil de management de la qualité et de promotion de l'innovation responsable

    OpenAIRE

    BARTHEL, Patrick

    2013-01-01

    L'objectif de ce papier est de décrire brièvement le modèle d'un marketing responsable élaboré sur la base de nombreuses études empiriques auprès de consommateurs et de responsables d'entreprise ; il vise surtout à montrer en quoi une telle orientation marketing participe de l'efficacité du management de la qualité tout en favorisant la promotion de l'innovation, et plus précisément l'innovation dite responsable.

  1. NOUVELLES TECHNOLOGIES EDUCATIVES, RISQUES PEDAGOGIQUES ET CONTROLE DE GESTION

    OpenAIRE

    Bescos, Pierre-Laurent

    2000-01-01

    International audience Les Nouvelles Technologies Educatives (NTE) peuvent être très utiles pour augmenter l'efficacité pédagogique et l'implication des étudiants, notamment pour des cours en comptabilité ou contrôle de gestion. Mais leur utilisation ne se fait pas sans certains risques, à partir du moment où cela s'accompagne nécessairement de nouvelles approches pédagogiques et du fait de la dépendance vis-à-vis des diverses technologies employées. A partir d'une expérimentation sur un c...

  2. ANALYSE DE L'ENCODAGE DES SIGNAUX DE PAROLE DANS LE TRONC CEREBRAL (SPEECH AUDITORY BRAINSTEM RESPONSE)

    OpenAIRE

    Akhoun, Idrick

    2008-01-01

    Les Speech ABR sont un outil prometteur d'exploration fonctionnelle auditive, qui pourrait à terme être implémenté en routine clinique afin de dépister la surdité et d'évaluer l'efficacité des techniques de réhabilitation auditive. Dans la Partie 1, nous présentons d'abord (i) une étude paramétrique quantifiant les effets de l'artefact électromagnétique, issu du couplage entre la chaine de stimulation et d'acquisition, sur le Speech ABR. Puis nous discutons (ii) les avantages de la représenta...

  3. Les représentations sociales de l'hypnose: une réflexion sur son acceptation dans les soins

    OpenAIRE

    Descloux, Fanny; Grosjean, Aïcha; Staffoni-Donadini, Liliana

    2013-01-01

    Introduction : De récentes études scientifiques ont prouvé l’efficacité de l’hypnose notamment pour la gestion des douleurs. Cependant elle est encore peu répandue dans les services hospitaliers en Suisse Romande. Les représentations sociales, façons personnelles de se représenter et d’interpréter le monde orientent le comportement humain. Concernant l’hypnose, elles jouent un rôle central dans les attitudes du patient et du thérapeute face à l’acceptation du phénomène. Objectif : Identifier ...

  4. Hypnose et douleurs chroniques: "est-ce que l'hypnose peut améliorer la qualité de vie des patients douloureux chroniques ?"

    OpenAIRE

    Granger, Julie; Duc, Céline; Hilfiker, Roger

    2012-01-01

    Au travers de cette revue systématique, nous souhaitons confirmer l’efficacité de l’hypnose dans le traitement de la douleur chronique. Nous avons recherché des études comparant deux groupes, l’un recevant uniquement des traitements physiothérapeutiques et l’autre de l’hypnose combinée à des traitements physiothérapeutiques. Mit dieser Systematischen Literaturübersicht möchten wir die Effizienz der Hypnose die Behandlung chronischer Schmerzen untersuchen. Wir haben Studien gesucht, die 2 G...

  5. Encore un effort pour rendre la gouvernance démocratique !

    OpenAIRE

    Pinson, Gilles

    2008-01-01

    Même s'il est souvent critiqué, le terme de «gouvernance» permet de rendre compte de réalités nouvelles : à l'échelle internationale ou locale, l'action publique s'est complexifiée. On ne commande plus si facilement aux hommes et aux choses. Mais la gouvernance sans gouvernement pose autant de problèmes qu'elle n'en résout puisque c'est son fonctionnement opaque, consensuel, à l'abri des regards, qui semble le garant de son efficacité.

  6. Conservation Priorities when Species Interact: The Noah's Ark Metaphor Revisited

    OpenAIRE

    Courtois, Pierre; Figuieres, Charles; Mulier, Chloé

    2014-01-01

    Cette note intègre les interactions écologiques dans le problème Arche de Noé [ML Weitzman, The Noah's Arch problem, Econometrica 66 (6) (1998) 1279-1298]. Ce faisant, nous arrivons à un modèle général pour étudier le classement des projets de conservation in situ pour des espèces en interactions, et nous offrons une méthode coût-efficacité opérationnelle afin de mieux préserver la diversité sous une contrainte de budget.

  7. Structures de données et méthodes formelles

    CERN Document Server

    Guyomard, Marc

    2011-01-01

    Ce livre porte sur l tude des structures de donn es, savoir des constituants logiciels dont la qualit conditionne le bon fonctionnement et l efficacit des applications informatiques. L originalit de cet ouvrage r side essentiellement dans le lien qu il tablit avec la discipline des m thodes formelles pour le g nie logiciel. Il montre comment il est possible de calculer les op rations qui accompagnent une structure de donn es partir d une sp cification rigoureuse. L auteur adopte la fois une perspective historique et une d marche fonctionnelle. La premi re partie de l ouvrage pr sente les bases

  8. Sarcoidosis presenting with severe hypocalcaemia.

    LENUS (Irish Health Repository)

    Saeed, A

    2012-01-31

    Disorders of calcium metabolism, especially hypercalcemia and hypercalceuria, are common in sarcoidosis. They are caused by extra renal unsuppressed production of 1,25 dihydroxy vitamin D at the level of the sarcoid granuloma. Hormonal changes during pregnancy have a physiological synergistic effect on this mechanism, which is primarily parathyroid hormone (PTH) dependant. However, the combination of primary hypoparathyroidism with hypocalcemia and sarcoidosis is rare. Di George syndrome, is a dysmorphic disorder characterised by aplasia\\/hypoplasia of thymus and parathyroid glands in addition to aortic arch anamolies and facial dysmorphia. After commencing appropriate treatment this lady made excellent recovary.

  9. The Effects of Nerve Growth Factor on Skin Healing and Blood Recovery in Irradiated Mice

    Institute of Scientific and Technical Information of China (English)

    史春梦; 程天民; 屈纪富

    2002-01-01

    @@ It is known that radiation could cause bone marrow aplasia and delay wound healing.To promote cellular proliferation and blood recovery are 2 major goals in the treatment of radiation injury.We have observed that the expression of nerve growth factor (NGF) gene decreased greatly in the wound tissue of irradiated animals by immunohistochemistry and in situ hybridization methods.This study was designed to elucidate the effects of NGF on the skin wound healing and blood recovery in mice after total body irradiation.

  10. Disease: H00847 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00847 Al-Awadi/Raas-Rothschild syndrome; Ulna and fibula, absence of, with sever l...imb deficiency Al-Awadi/Raas-Rothschild syndrome is a limb malformation disorder that has overlapping phenot...7A function in Al-Awadi/Raas-Rothschild syndrome whereas impairment is partial in...(description) Camera G, Ferraiolo G, Leo D, Spaziale A, Pozzolo S Limb/pelvis-hypoplasia/aplasia syndrome (Al-Awadi/Raas-Rothschild...range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia sy

  11. The role of human ribosomal proteins in the maturation of rRNA and ribosome production

    OpenAIRE

    Robledo, Sara; Rachel A Idol; Crimmins, Dan L.; Ladenson, Jack H.; Mason, Philip J.; Bessler, Monica

    2008-01-01

    Production of ribosomes is a fundamental process that occurs in all dividing cells. It is a complex process consisting of the coordinated synthesis and assembly of four ribosomal RNAs (rRNA) with about 80 ribosomal proteins (r-proteins) involving more than 150 nonribosomal proteins and other factors. Diamond Blackfan anemia (DBA) is an inherited red cell aplasia caused by mutations in one of several r-proteins. How defects in r-proteins, essential for proliferation in all cells, lead to a hum...

  12. MURCS association--a review of 7 cases.

    Directory of Open Access Journals (Sweden)

    Mahajan P

    1992-07-01

    Full Text Available MURCS association (Mullerian hypoplasia/aplasia, renal agenesis and cervicothoracic somite dysplasia is emerging as the second most frequent cause of primary amenorrhoea after Turner syndrome. Seven cases have been described and analysed. All cases had absence of uterus and tubes 85% had cervical spine abnormalities such as vertebral fusion, hypoplasia of vertebrae or butterfly vertebrae and short stature and 28% had renal agenesis or ectopy. The latter finding is in contrast to the reports in world literature where the frequency of renal agenesis is higher. There was no familial incidence in these seven cases lending credence to the belief that the association is essentially sporadic.

  13. Derrame pleural en enfermedad de Milroy

    OpenAIRE

    Juan José Celis-Jiménez; María Daniela Barrios-Morales; Lorena Verónica Martínez-Zamora; Sara Inés Briceño Berbesí; José David Betancourt Salinas; Francisco R. Cammarata Scalisi

    2013-01-01

    La enfermedad de Milroy, también conocida como linfedema congénito primario, fue descrita inicialmente en 1892 por William Forsyth Milroy. Es una afección que se presenta generalmente en el nacimiento, o bien durante la infancia, de origen genético con patrón de herencia autosómico dominante, causada por un defecto en el receptor 3 del factor de crecimiento endotelial vascular VEGFR3, lo que conlleva a hipoplasia o aplasia de vasos linfáticos, mayormente de miembros inferiores hecho que se ma...

  14. Screening for neonatal hypothyroidism using filter paper spot TSH (RIA) in Beijing

    International Nuclear Information System (INIS)

    From May 1985 to December 1987, a survey of 15500 newborns for neonatal hypothyroidism using filter paper spot RIA for TSH and T4 was carried out in Beijing. Those infants with TSH values higher than 25 mU/L and/or T4 values lower than 3 μg/dl were recalled for further examination. The recall rate was 0.56%. Two infants were confirmed to have congenital hypothyroidism by serum TSH, T4(RIA) and thyroid scintigraphy wity 99mTc pertechnetate. One showed thyroid aplasia and the other ectopic thyroid. The incidence of hypothyroidism was 1:7750

  15. Ectodermal dysplasia - Maxillary and mandibular alveolar reconstruction with dental rehabilitation: A case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Deshpande Sanjeev

    2010-01-01

    Full Text Available Ectodermal dysplasia is a rare group of inherited disorders characterized by aplasia or dysplasia of tissues of ectodermal origin, such as hair, nails, teeth and skin. Dental manifestations include hypodontia, complete anodontia or malformed teeth. Oral rehabilitation is the major surgical challenge in such patients. It frequently requires alveolar reconstruction followed by dental implants. We report a case of hypohidrotic ectodermal dysplasia, which was managed with reconstruction of both the upper and the lower alveolus using free fibula flaps with dental rehabilitation using osseointegrated implants.

  16. Tratamiento de las hipoplasias severas del pulgar mediante modificaciones a la técnica de Buck-Gramcko

    OpenAIRE

    Peña Marrero, Liván

    2008-01-01

    En este trabajo se evalúa la efectividad de una modificación diseñada por el autor a la técnica de pulgarización del dedo índice descrita por Dieter Buck-Gramcko para el tratamiento de las hipoplasias y aplasias del pulgar. Se realizó un estudio prospectivo longitudinal en 17 pacientes distribuidos en dos grupos. El grupo A estuvo constituido por 9 pacientes (10 manos operadas) a quienes se le aplicó como tratamiento la técnica original de Buck-Gramcko. El grupo B estuvo integrado por 8 pacie...

  17. The athymic nude rat. Immunobiological characteristics with special reference to establishment of non-antigen-specific T-cell reactivity and induction of antigen-specific immunity

    DEFF Research Database (Denmark)

    Hougen, H P

    1991-01-01

    white pulp, and the interfollicular areas of Peyer's patches, are severely cell-depleted in the athymic nude rat. The lower lymphocyte content of these organs is not reflected in the lymphocyte counts of peripheral blood, but the lymphocyte counts of thoracic duct lymph are much lower than those found...... the thymic aplasia. Normal B-lymphocyte function has been found in both in vitro and in vivo tests, whereas the T-cell function is virtually absent both in vitro and in vivo. Non-MHC-restricted cells with killer activity like NK cells are present in the nude rat, and these cells function normally both...

  18. Prolonged gestation in two Holstein cows: transabdominal ultrasonographic findings in late pregnancy and pathologic findings in the fetuses.

    Science.gov (United States)

    Buczinski, S; Bélanger, A-M; Fecteau, G; Roy, J-P

    2007-12-01

    Prolonged pregnancy in cattle is a rare condition that is commonly accompanied with fetal adenohypophyseal hypoplasia. The final diagnosis is often challenging as breeding date error remains possible in virtually all situations. In this report, fetal wellbeing assessment is depicted in two Holstein cows suffered from prolonged pregnancy. Transabdominal ultrasonographic findings were compatible with healthy non-stressed fetuses. The clinical and pathologic findings encountered in both fetuses expelled after corticosteroid induction of parturition consisted of adenohypophyseal aplasia and hydronephrosis. Other nervous system anomalies (hydrocephaly or holocephaly) were observed. Tetralogy of Fallot was also found in one calf.

  19. Infecção por Chryseobacterium indologenes: relato de um caso Chryseobacterium indologenes infection: a case report

    OpenAIRE

    Renata de Souza Ferreira; Fabiana Ferreira Barbosa Brandão; Suzana Margareth Lobo

    2010-01-01

    Relatamos um caso de infecção por Chryseobacterium indologenes, presente na cultura de aspirado traqueal em paciente sob ventilação mecânica invasiva, revisando os aspectos epidemiológicos, microbiológicos e o tratamento na unidade de terapia intensiva. Paciente do sexo masculino, 30 anos, internado com quadro de aplasia de medula idiopática e neutropenia febril foi transferido para a unidade de terapia intensiva com quadro de broncopneumonia e sepse grave de origem pulmonar. A maioria dos ca...

  20. Hematopoietic Stem Cell Transplantation and History

    Directory of Open Access Journals (Sweden)

    Atila Tanyeli

    2014-02-01

    Full Text Available Attemps to employ marrow stem cell for therapeutic purpose began in 1940’s. Marrow transplantation might be of use not only in irradiation protection, but also with therapeutic aim to marrow aplasia, leukemia and other diseases. The use and defining tissue antigens in humans were crucial to the improving of transplantation. The administration of methotrexate for GVHD improved the long term survival. Conditioning regimens for myeloablation designed according to diseases. Cord blood and peripheral blood stem cells were used for transplantion after 1980’s. Cord blood and bone marrow stem cell banks established to find HLA matched donor.

  1. How many breaks do we need to CATCH on 22q11?

    Energy Technology Data Exchange (ETDEWEB)

    Dallapiccola, B.; Pizzuti, A.; Novelli, G. [Univ. of Rome, Rome (Italy)]|[Univ. of Milan (Italy)]|[CSS IRCCS Hospital, San Giovanni Rotondo (Italy)

    1996-07-01

    The major clinical manifestations of DiGeorge syndrome (DGS; MIM 188400), which reflect developmental abnormalities of the 3d and 4th pharyngeal pouch derivatives, include thymus- and parathyroid-gland aplasia or hypoplasia and conotruncal cardiac malformations. The additional dysmorphic facial features, such as hypertelorism, cleft lip and palate, bifid uvula, and small/low-set ears, which are also common, presumably reflect the same defect. The DGS phenotype has been associated with chromosome abnormalities and, sometimes, is the effect of teratogenic agents such as retinoic acid and alcohol. 53 refs., 1 fig.

  2. Developmental defects of the lungs

    Energy Technology Data Exchange (ETDEWEB)

    DaCosta, H.; Pathak, A.; Noronha, O.; Dalal, S.; Shah, K.; Merchant, S.

    1981-06-01

    Poor lung development was first noted on scintigraphy using sup(99m)Tc-phytate in 32 children. They had all been referred for a hepatosplenic scan but the initial circulatory phase of the radiopharmaceutical was also recorded as a routine procedure. In 3 patients it revealed aplasia of an entire lung; bilateral pulmonary hypolplasia was observed in 14 of 16 patients with diaphragmatic herniae. Six patients with congenital heart enlargement showed a poorly developed ipsilateral lung; 5 of 6 patients with dextrocardia without an intracardiac defect had a larger left lung compared with the right lung; both pulmonary beds appeared equal in a patient with mesocardia.

  3. [A new (?) multiple abnormality complex similar to the Poland syndrome].

    Science.gov (United States)

    Gugliantini, P; Saguì, L; Parri, C; Seganti, G; Cavalletti, P

    1984-01-01

    The report describes a case Poland's Syndrome - like in which the hypoplasia of the left major pectoralis muscle was associated with: subtotal aplasia of sternal body, severe hypoplasia of the ipsilateral scapula, humerus and forearm bones, tetradactyly in the ipsilateral hand, partial defect of the diaphragm with thoracic migration of the left hepatic lobe and secondary dextrocardia (false dextrocardia). Syndactyly was absent. The contribution is aimed to join out the radiological characteristics of the syndrome as well as the specific contribution provided in the case by Ultrasounds and aortography. Furthermore, the analysis of the case seems to indicate a strict relationship between the abnormalities of diaphragm, pectoralis muscle and homolateral upper limb.

  4. Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma

    Institute of Scientific and Technical Information of China (English)

    Bernhard Glodny; Alexandar Tzankov; Germar-Michael Pinggera; Johannes Petersen; Ralf Herwig

    2006-01-01

    A 32-year-old man recovered completely from hypokalemic hypertension that had been caused by primary reninism after the ablation of an ectopic left testis, epididymis and ductus deferens. For several years, severe hypertension has been resistant to treatment, even the concurrent administration of up to seven antihypertensive agents. In this case,cryptorchidism was associated with an indirect inguinal hernia and an open peritoneo-vaginal process on both sides,aplasia of the posterior wall of the inguinal canal on the right side, an umbilical hernia, and a retroperitoneal tendrillar hemangioma.

  5. Mutations in different components of FGF signaling in LADD syndrome.

    Science.gov (United States)

    Rohmann, Edyta; Brunner, Han G; Kayserili, Hülya; Uyguner, Oya; Nürnberg, Gudrun; Lew, Erin D; Dobbie, Angus; Eswarakumar, Veraragavan P; Uzumcu, Abdullah; Ulubil-Emeroglu, Melike; Leroy, Jules G; Li, Yun; Becker, Christian; Lehnerdt, Kai; Cremers, Cor W R J; Yüksel-Apak, Memnune; Nürnberg, Peter; Kubisch, Christian; Kubisch, Chriütian; Schlessinger, Joseph; van Bokhoven, Hans; Wollnik, Bernd

    2006-04-01

    Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3) in LADD families, and in one further LADD family, we detected a mutation in the gene encoding fibroblast growth factor 10 (FGF10), a known FGFR ligand. These findings increase the spectrum of anomalies associated with abnormal FGF signaling. PMID:16501574

  6. Ultrasonography of various thyroid diseases in children and adolescents: A pictorial essay

    International Nuclear Information System (INIS)

    Thyroid imaging is indicated to evaluate congenital hypothyroidism during newborn screening or in cases of a palpable thyroid mass in children and adolescents. This pictorial essay reviews the ultrasonography (US) of thyroid diseases in children and adolescents, including normal thyroid gland development, imaging features of congenital thyroid disorders (dysgenesis, [aplasia, ectopy, hypoplasia], dyshormonogenesis, transient hypothyroidism, thyroglossal duct cyst), diffuse thyroid disease (Grave's disease, Hashimoto's thyroiditis, and suppurative thyroiditis), and thyroid nodules. The primary imaging modalities for evaluating thyroid diseases are US and radionuclide scintigraphy. Additionally, US can be used to guide aspiration of detected nodules.

  7. Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma.

    Science.gov (United States)

    Glodny, Bernhard; Tzankov, Alexandar; Pinggera, Germar-Michael; Petersen, Johannes; Herwig, Ralf

    2006-03-01

    A 32-year-old man recovered completely from hypokalemic hypertension that had been caused by primary reninism after the ablation of an ectopic left testis, epididymis and ductus deferens. For several years, severe hypertension has been resistant to treatment, even the concurrent administration of up to seven antihypertensive agents. In this case, cryptorchidism was associated with an indirect inguinal hernia and an open peritoneo-vaginal process on both sides, aplasia of the posterior wall of the inguinal canal on the right side, an umbilical hernia, and a retroperitoneal tendrillar hemangioma. PMID:16491279

  8. TREATMENT OF 30 CASES OF INFANTILE HIGH FEVER WITH ERJIAN-POINT BLOOD-LETTING METHOD

    Institute of Scientific and Technical Information of China (English)

    李赛玲; 朱军

    2001-01-01

    High fever is referred to that the body temperature exceeds 39℃. Due to aplasia of the cerebral nerve system during infantile stage, continuous high fever may induce temporary functional disturbance of the brain, manifesting as sudden and transient loss of consciousness and local or general muscular spasm that is termed as infantile convulsion. The authors find in clinical practice that sometimes, administration of antipyretics as compound aspirin (APC), compound aminopyrine, etc. has no effect on infantile high fever, if treated with Erjian (MA-H 6) bleeding method, the body temperature may be decreased by 0.5~1.0℃. Here is the report.

  9. Terrorist threat, chemical, biological, radiological, nuclear medical approach

    International Nuclear Information System (INIS)

    The different aspects linked to the use of nuclear, radiological, biological and or chemical weapons are gathered in this work. They concern history, fundamental aspect, diagnosis, therapy and prevention. The part devoted to the nuclear aspect concern the accidents in relation with ionizing radiations, the radiation syndrome, the contribution and limits of dosimetry, the treatment of medullary aplasia, the evaluation and treatment of an internal contamination, new perspectives on the use of cytokine for the treatment of accidental irradiated persons, alternative to the blood transfusion. (N.C.)

  10. Multifocal Aeromonas Osteomyelitis in a Child with Leukemia

    Directory of Open Access Journals (Sweden)

    Dimitrios Doganis

    2016-01-01

    Full Text Available Aeromonas hydrophila is a Gram negative organism causing both intestinal and extraintestinal disease. The case of a 14-year-old girl with underlying immunodeficiency and leukemia who developed systemic A. hydrophila infection is described in this report. While in deep bone marrow aplasia she developed fever, severe pain in the lower extremities, and swelling of the left femur. Blood culture showed Escherichia coli and A. hydrophila whereas pus culture from the soft tissue swelling showed the presence of A. hydrophila. Imaging studies showed diffuse osteolytic lesions. Patient received 5 months of intravenous and oral antibiotics and she improved clinically whereas the radiology findings persisted.

  11. El síndrome de Kallmann. Correlación fenotipo-genotípica.

    OpenAIRE

    García Piñero, Alfonso José

    2015-01-01

    El Síndrome de Kallmann (SK) es una enfermedad genética del desarrollo, que asocia un hipogonadismo hipogonadotrópico (HH) congénito con pérdida total (anosmia) o parcial (hiposmia) del olfato. La alteración olfativa es secundaria a la aplasia o hipoplasia de las estructuras olfatorias (bulbos, tractos y surcos cerebrales olfatorios). El HH se debe a la deficiencia en la hormona liberadora de gonadotropinas hipotalámica (GnRH) como resultado del fallo en la migración de las neuronas productor...

  12. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab.

    Science.gov (United States)

    Krishnan, Suresh K; Hill, Anita; Hillmen, Peter; Arnold, Louise M; Brooksbank, Gemma L; Wood, Alex; Scarsbrook, Andrew; Davies, Mervyn H; Kelly, Richard J

    2013-12-01

    Paroxysmal nocturnal hemoglobinuria is a rare acquired stem cell disorder characterized by intravascular hemolysis, aplasia and an increased risk of thrombosis. We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly. The patient underwent two separate splenic embolizations, which reduced the size of the spleen and improved his blood count to the point that blood transfusions were no longer necessary. Splenic embolization was chosen over splenectomy due to the potential postoperative complications of splenectomy, especially that of thrombosis.

  13. [Non-steroidal antirheumatics: side-effects and interactions].

    Science.gov (United States)

    Felder, M

    1982-08-28

    Side effects of non-steroidal antirheumatic drugs (NSAD) may occur in any organ system, since the prostaglandins, the synthesis of which is inhibited by NSAD, play a role in numerous adverse cellular processes throughout the body. Besides these physiologic regulations there are adverse effects of NSAD, such as bone marrow aplasia, of unexplained etiology. The interactions of NSAD are of clinical relevance in drug types such as the salicylates, pyrazolons and fenamic acids (e.g. interactions with cumarin derivatives). The clinically relevant interactions of NSAD are discussed in detail. PMID:6982512

  14. Bilateral dyb venos trombose og vena cava-aplasi behandlet med lokal trombolyse

    DEFF Research Database (Denmark)

    Pelta, A.M.; Jorgensen, M.; Jensen, L.P.;

    2008-01-01

    In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete thr...... thrombus resolution and no valvular incompetence at three months follow-up. In our opinion this treatment should be offered even in complex cases of acute proximal deep venous thrombosis Udgivelsesdato: 2008/5/19...

  15. Ehrlichia canis infection in a dog with no history of travel outside the United Kingdom.

    Science.gov (United States)

    Wilson, H E; Mugford, A R; Humm, K R; Kellett-Gregory, L M

    2013-08-01

    A two-year-old female neutered Tibetan terrier was referred following a one-month history of lethargy, inappetence and pancytopenia, which had been poorly responsive to immunosuppressive and fluoroquinolone treatment. The dog was diagnosed with pure red cell aplasia and was found to be positive for Ehrlichia canis by both antibody titre measurement and polymerase chain reaction. The dog lived in London and had not travelled outside the UK. The dog was treated with doxycycline, prednisolone and ciclosporin, but died as a result of gastrointestinal tract haemorrhage. To the authors' knowledge, this represents the first reported case of Ehrlichia canis in a dog in the UK with no previous travel history.

  16. Disease: H00464 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00464 Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patel...la-short statute syndrome Patella dysplasias are a group of disorders that include aplasia/hypoplasia of patel...lar. Small patella syndrome is a skeletal dysplasia with anomalies of the pelvis. Ossific...ation of the ischia and inferior pubic rami is also disrupted in patients with small patel...la syndrome. Nail-patella syndrome is a condition caused by mutation in LMX1B that regulates COL4A4

  17. Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.

    LENUS (Irish Health Repository)

    Kelly, Kevin

    2008-12-01

    Aplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.

  18. Ultrasonography of various thyroid diseases in children and adolescents: A pictorial essay

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Sook; Lee, Eun Hye; Jeong, Sun Hye; Park, Ji Sang; Lee, Heon [Dept. of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon (Korea, Republic of)

    2015-04-15

    Thyroid imaging is indicated to evaluate congenital hypothyroidism during newborn screening or in cases of a palpable thyroid mass in children and adolescents. This pictorial essay reviews the ultrasonography (US) of thyroid diseases in children and adolescents, including normal thyroid gland development, imaging features of congenital thyroid disorders (dysgenesis, [aplasia, ectopy, hypoplasia], dyshormonogenesis, transient hypothyroidism, thyroglossal duct cyst), diffuse thyroid disease (Grave's disease, Hashimoto's thyroiditis, and suppurative thyroiditis), and thyroid nodules. The primary imaging modalities for evaluating thyroid diseases are US and radionuclide scintigraphy. Additionally, US can be used to guide aspiration of detected nodules.

  19. Evolutions et enjeux de la coopération internationale au développement

    Directory of Open Access Journals (Sweden)

    Gérard Perroulaz

    2010-03-01

    Full Text Available Le volume de l’aide publique au développement (APD fournie par les pays de l’OCDE atteint de nouveaux records. Les flux enregistrés au titre de l’APD incluent toutefois des catégories de dépenses qui ne concourent pas à l’objectif de réduction de la pauvreté dans les pays en développement. Les économies émergentes et les donateurs privés procurent une part croissante de l’aide. Des progrès ont été réalisés dans la mise en œuvre de la Déclaration de Paris sur l’efficacité de l’aide dans quelques domaines comme le déliement de l’aide, mais les résultats ne sont pas à la hauteur des attentes. L’approche demeure trop souvent techniciste et élude les dynamiques politiques qui ont une incidence majeure sur l’efficacité de l’aide. La question de la cohérence des politiques publiques au service du développement revient sur le devant de la scène, alors que les débats sur le changement climatique appellent à reconsidérer certains objectifs et stratégies des agences de coopération.

  20. Optimization of flight control parameters of an aircraft using genetic algorithms

    Science.gov (United States)

    Garcia Aguilar, Sixto Ernesto

    Ce travail presente de nouvelles methodes pour ameliorer la performance des algorithmes genetiques pour l'optimisation des gains du controleur d'un systeme de vol electrique des avions commerciaux. Nous avons combine les caracteristiques de deux operateurs de mutation, uniforme et non uniforme, au sein d'un nouvel operateur, de type periodique. Nous avons propose un nouveau modele avec contraintes et nous avons fait la conception d'un nouvel operateur de selection stochastique pour augmenter l'efficacite d'un algorithme genetique du codage reel (RGA) applique aux problemes d'optimisation avec contraintes. Pour la conception de l'operateur de selection sous contraintes, nous avons applique une methode qui peut manipuler la proportion d'individus faisables et non faisables sans negliger le comportement dynamique du GA. Finalement, nous avons reduit de 25% le temps d'execution original et ameliore l'efficacite des RGAs en combinant l'application d'un index de diversite d'une population d'un algorithme genetique ainsi qu'un reseau de Bayes (BN).

  1. L’Europe des lipides : enjeux et méthode

    Directory of Open Access Journals (Sweden)

    Parmentier Michel

    2000-03-01

    Full Text Available Ce n’est pas la première fois que les chercheurs et les industriels européens tentent de s’organiser dans le but de s’identifier et de se renforcer, face à la puissance et l’organisation du grand partenaire américain. L’AOCS (American oil chemists Society, dont tous les Européens connaissent l’efficacité et utilisent les services, possède en effet une image irremplaçable dans le secteur : ses journaux, ses congrès, sa présence dans l’ISF (International society for fat research, toute la communication « Lipides » qu’elle véhicule sont pour le chercheur européen une aide précieuse. Ce devrait être également pour tous une incitation à la fois forte et récurrente à une affirmation de l’identité et de l’autonomie du Vieux continent. Inconsciemment ou consciemment, comme dans de nombreux (pour ne pas dire tous domaines scientifiques et techniques, l’Amérique nous aiguillonne, nous impressionne, nous culpabilise dans notre atavique incapacité à monter dans le même train de l’efficacité et de la puissance affirmée.

  2. Assessment of the impact of adherence and other predictors during HAART on various CD4 cell responses in resource-limited settings

    Directory of Open Access Journals (Sweden)

    Abrogoua DP

    2012-03-01

    Full Text Available Danho Pascal Abrogoua1,2, Brou Jerome Kablan1, Boua Alexis Thierry Kamenan1,3, Gilles Aulagner4, Konan N'Guessan1, Christian Zohoré11Laboratoire de Pharmacie Clinique, Pharmacologie et Therapeutique – UFR Sciences Pharmaceutiques et Biologiques, 2Laboratoire de Pharmacologie Clinique, CHU de Cocody, 3Service de Pharmacie, CHU de Cocody, Abidjan, Cote d'Ivoire, 4Service Pharmaceutique Hopital Louis Pradel, Lyon, FranceObjective: The aim of this study was to quantify, by modeling, the impact of significant predictors on CD4 cell response during antiretroviral therapy in a resource-limited setting.Methods: Modeling was used to determine which antiretroviral therapy response predictors (baseline CD4 cell count, clinical state, age, and adherence significantly influence immunological response in terms of CD4 cell gain compared to a reference value at different periods of monitoring.Results: At 6 months, CD4 cell response was significantly influenced by baseline CD4 count alone. The probability of no increase in CD4 cells was 2.6 higher in patients with a baseline CD4 cell count of ≥200/mm3. At 12 months, CD4 cell response was significantly influenced by both baseline CD4 cell count and adherence. The probability of no increase in CD4 cells was three times higher in patients with a baseline CD4 cell count of ≥200/mm3 and 0.15 times lower with adherent patients. At 18 months, CD4 cell response was also significantly influenced by both baseline CD4 cell count and adherence. The probability of no increase in CD4 cells was 5.1 times higher in patients with a baseline CD4 cell count of ≥200/mm3 and 0.28 times lower with adherent patients. At 24 months, optimal CD4 cell response was significantly influenced by adherence alone. Adherence increased the probability (by 5.8 of an optimal increase in CD4 cells. Age and baseline clinical state had no significant influence on immunological response.Conclusion: The relationship between adherence and CD4

  3. Une porte optique intensificatrice picoseconde a gain eleve: Caracterisation et application potentielle en imagerie de petits objets places dans des milieux diffusants

    Science.gov (United States)

    Marengo, Stephanie

    Dans cette etude, nous avons developpe un amplificateur a colorant possedant ces deux caracteristiques. Le colorant choisi, l'iodure de 3,3'-dimethyloxatricarbocyanine (methyl-DOTCI), possede un epaulement dans la bande d'absorption a 620 nm ce qui convient bien a notre pompe femtoseconde. De plus, son maximum de fluorescence est a 720 nm ce qui est particulierement interessant dans le cas des etudes avec des tissus biologiques humains. En effet, la fenetre dite "therapeutique" se situe dans les longueurs d'onde rouge et proche infrarouge. Le phenomene d'amplification, qui se produit dans des conditions experimentales precises, est en fait une emission stimulee du colorant qui est largement favorisee par rapport a sa fluorescence naturelle (emission spontanee). L'arrivee du signal incident, dont la longueur d'onde correspond au saut energetique entre l'etat fondamental et l'etat excite ou se trouvent les molecules, provoque une avalanche coherente de celles-ci vers l'etat fondamental generant ainsi l'emission stimulee. Une des conditions necessaires pour l'obtention d'un gain eleve est que la duree de l'impulsion de pompe soit inferieure au temps de relaxation des molecules ainsi qu'inferieure au temps requis pour effectuer un trajet dans la cellule de colorant. Ceci nous a permis d'amplifier un signal incident par un facteur entre 103 et 104. De plus, ce gain eleve n'est observe qu'a l'interieur d'une fenetre temporelle d'environ 10 picosecondes. Nous avons integre cet amplificateur a notre montage de transillumination afin d'acquerir des images d'un patron de lignes opaques immerge dans un milieu diffusant liquide. Des images de lignes ayant une resolution spatiale de 200 mum ont ete obtenues. La cible etait placee au centre d'un melange contenant des proportions variables de lait et d'eau. Deux longueurs de trajet optique dans la solution ont ete utilisees: 30 et 50 mm. Pour determiner les proprietes optiques de notre milieu diffusant, nous avons mis au point

  4. SÍNDROME DE MAYER-ROKITANSKY-KÜSTER-HAUSER TIPO II: REPORTE DE UN CASO Y REVISIÓN DE OPCIONES TERAPÉUTICAS

    Directory of Open Access Journals (Sweden)

    Héctor Silva Cárcamo

    2016-07-01

    Full Text Available El Síndrome de Mayer-Rokitansky-Küster-Hauser, es una anomalía poco frecuente, causada por aplasia de conductos de Müller, se caracteriza por ausencia congénita de vagina, alteraciones uterinas (variedad tipo I, acompañada de alteraciones renales y/o esqueléticas (variedad tipo II, con fenotipo femenino y función ovárica normal. Su incidencia es 1 en 4000-5000 mujeres. Caso clínico: Segundo caso reportado en Honduras, paciente femenina, 17 años de edad, acude por presentar amenorrea primaria, dolor pélvico intenso, sin atenuantes coincidiendo una vez al mes. Al examen físico encontramos presentes características sexuales secundarias, genitales femeninos externos normales, ausencia total del conducto vaginal que imposibilita realizar tacto vaginal. Se realizan estudios de imagen como USG, pielograma intravenoso reportando: útero didelfo infantil y ectopia renal. La laparotomía exploratoria revela alteraciones renales y trompas rudimentarias. Discusión: El tratamiento indicado es la colpopoiesis o neovagina con diferentes métodos quirúrgicos o no quirúrgicos para el completo desarrollo sexual y psicológico de la paciente. Palabras Clave: Amenorrea, conductos de Müller, Aplasia

  5. CT myelography characteristics of spinal dysraphism in a young mixed breed dog Características de mielografía con TC de una disrafia espinal en un perro mestizo joven

    Directory of Open Access Journals (Sweden)

    M Gómez

    2012-01-01

    Full Text Available Spinal dysraphism is a congenital defect of the vertebral column and spinal cord secondary to imperfect closure of the caudal neuropore of the developing neural tube. This report describes computed tomographic myelography (Myelo-CT characteristics of spina bifida occulta, spinal cord aplasia/hypoplasia and split cord malformation type II (diplomyelia in the caudal lumbar area of a 2 month old mixed breed dog.La disrafia espinal es un defecto congénito de la columna vertebral y la médula espinal secundaria a un cierre imperfecto del neuroporo caudal del tubo neural en desarrollo. Este reporte describe las características observadas en una mielografía por tomografía computarizada (mielo-TC de una espina bífida oculta, aplasia/hipoplasia segmentaria de médula espinal y duplicación de médula espinal tipo II (diplomielia en el segmento lumbar caudal de un perro mestizo de dos meses de edad.

  6. Pectus excavatum, pectus carinatum and other forms of thoracic deformities

    Directory of Open Access Journals (Sweden)

    Saxena Amulya

    2005-01-01

    Full Text Available This review article covers the spectrum of congenital thoracic wall deformities along with their historical background. Willital′s classification divides these deformities into 11 types - funnel chest (4 types, pigeon chest (4 types, and combination of funnel and pigeon chest, chest wall aplasia and cleft sternum. Records of patients at our center comprised 90% depression deformities, 6% protrusion deformities, 3% combined depression-protrusion deformities and 1% other forms. Mild forms of abnormalities warrant the wait- and-watch approach during the first 4-5 years. The deformities manifest primarily during the pubertal spurt often with rapid progression with subjective complaints like dyspnea, cardiac dysthesia, limited work performance and secondary changes. Operative correction in young adults is more favorable in mild cases. The Willital technique has been the standard technique for the correction of pectus excavatum, pectus carinatum and other combined forms of deformities at our center with excellent long term results. The Nuss procedure and the Pectus Less Invasive Extrapleural Repair (PLIER technique for pectus excavatum and pectus carinatum have also been described in this article. Surgical correction for Poland′s syndrome is reserved for patients with severe aplasia of the ribs with major depression deformity. Sternal defects including various types of ectopia cordis are discussed. Even after surgical correction, there is significant reduction in the total capacity and inspiratory vital capacity of the lungs, probably a result of the decreased compliance of the chest wall. However, the efficiency of breathing at maximal exercise improves significantly after operation.

  7. Prenatal Diagnosis of Bilateral Ectrodactyly and Radial Agenesis Associated with Trisomy 10 Mosaicism

    Directory of Open Access Journals (Sweden)

    Jonathan Lévy

    2013-01-01

    Full Text Available Ectrodactyly or split hand and foot malformations (SHFMs are rare malformations of the limbs, characterized by median clefts of the hands and feet, syndactyly, and aplasia and/or hypoplasia of the phalanges. They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. Bilateral radial ray defects comprise also a large heterogenous group of disorders, including trisomy 18, Fanconi anemia, and thrombocytopenia-absent-radius syndrome, not commonly associated with ectrodactyly. The present paper describes a case of ectrodactyly associated with bilateral radial ray defects, diagnosed in the first trimester of pregnancy, in a fetus affected by trisomy 10. Only four cases of sporadic and isolated ectrodactyly, diagnosed by ultrasonography between 14 and 22 weeks’ gestation, have been reported. To our knowledge, the present case is the first report of mosaic trisomy 10 associated with SHFM and radial aplasia. Trisomy 10 is a rare lethal chromosomal abnormality, most frequently found in abortion products. Only six liveborn mosaic trisomy 10 infants, with severe malformations, dead in early infancy, have been reported. A severe clinical syndrome can be defined, comprising ear abnormalities, cleft lip/palate, malformations of eyes, heart, and kidneys, and deformity of hands and feet and most often associated with death neonatally or in early infancy.

  8. Combined use of frontal sinus and nasal septum patterns as an aid in forensics: A digital radiographic study

    Directory of Open Access Journals (Sweden)

    Pradhuman Verma

    2015-01-01

    Full Text Available Background: Skull radiographic examination is a potentially useful procedure for the personal identification in cases where fragments of skull persist with no likelihood of identification based on dental arch. Aims: The study was to determine the uniqueness and reliability of combined frontal sinus (FS and nasal septum (NS patterns as observed on posterioanterior (PA cephalograms for personal identification. Materials and Methods: The randomly selected 149 digital PA cephalograms taken on Kodak 8000C Digital Panoramic and Cephalometric system were evaluated for patterns of FS and NS. Also the distribution of lobulations, area, and ratio of height/width of FS was calculated. The data obtained was statistical analyzed using Pearson′s coefficient correlation. Results: FS symmetry was observed in 78.5% and asymmetry in 7.3% subjects. Bilateral aplasia was noticed in 5.3% and unilateral aplasia in 8.7% of subjects. The total lobulation of FS was noted more in males on both sides while center lobes were observed slightly more in females. The straight NS was maximally seen followed by reverse sigmoid. The mean ratio of width/height of FS was observed more in males and highly significant correlation was observed with both sexes. The mean area of FS was noted more in males. There was significant correlation found between patterns of NS and FS except in right dominated asymmetrical FS. Conclusion: The combined use of FS and NS patterns could be used as method for identification by exclusion in forensics.

  9. CT characterization of developmental variations of the paranasal sinuses in cystic fibrosis

    International Nuclear Information System (INIS)

    Purpose: To describe variations of paranasal sinus development in patients with cystic fibrosis (CF) and in non-CF patients examined for inflammatory sinonasal disease. We focused on anatomic variants that predispose to orbital and cerebral penetration during functional endoscopic sinus surgery (FESS), e.g. hypoplasia of the maxillary sinus and low ethmoid roof. Material and Methods: One hundred and sixteen CF patients (3-54 years, median 18) and 136 control patients (7-51 years, median 31) were examined with coronal CT of the paranasal sinuses. CF patients were grouped according to number of confirmed mutations: CF-2 (n=70), CF-1 (n=32), CF-0 (n=14). CT images were evaluated with respect to paranasal sinus development, pneumatization variants and bony variants. Results: Frontal sinus aplasia and maxillary, ethmoid, and sphenoid sinus hypoplasia were markedly more frequent in CF-2 than in control patients. No CF-2 patient had pneumatization variants such as Haller cells or concha bullosa. Low ethmoid roof was seen in 30% of CF-2 children, but in no control children. CF-1 and CF-0 groups had prevalences of aplasia and hypoplasia intermediate to that of CF-2 and control patients. Conclusion: Genetically verified CF patients had less developed sinuses, lacked pneumatization variants, and more often had anatomic variants that predispose to complications during FESS. Normally developed sinuses and pneumatization variants in some genetically unverified CF patients (CF-1, CF-0) suggest that these patients may be erroneously diagnosed

  10. Infecção por Chryseobacterium indologenes: relato de um caso Chryseobacterium indologenes infection: a case report

    Directory of Open Access Journals (Sweden)

    Renata de Souza Ferreira

    2010-03-01

    Full Text Available Relatamos um caso de infecção por Chryseobacterium indologenes, presente na cultura de aspirado traqueal em paciente sob ventilação mecânica invasiva, revisando os aspectos epidemiológicos, microbiológicos e o tratamento na unidade de terapia intensiva. Paciente do sexo masculino, 30 anos, internado com quadro de aplasia de medula idiopática e neutropenia febril foi transferido para a unidade de terapia intensiva com quadro de broncopneumonia e sepse grave de origem pulmonar. A maioria dos casos já relatados de pacientes com infecção por Chryseobacterium indologenes apresentavam patologias graves associadas e infecções polimicrobianas que podem dificultar a interpretação da efetividade da terapia antimicrobiana contra este agente.A case of Chryseobacterium indologenes infection is reported, identified in an invasive mechanic ventilation patient's tracheal aspiration material. Epidemiological, microbiological, and intensive care unit therapy aspects are discussed. The patient was a 30 years-old male, admitted with idiopathic medullary aplasia and febrile neutropenia, referred to the intensive care unit with severe bronchopneumonia and sepsis of pulmonary origin. Most of the previously reported Chryseobacterium indologenes infection cases were associated with severe diseases and polymicrobial infections which could make difficult interpreting antimicrobial therapy options against this agent.

  11. Ectrodactilia em cão (Canis domestica Ectrodactilia in dog (Canis domestica

    Directory of Open Access Journals (Sweden)

    Daniela Oliveira

    2002-12-01

    Full Text Available O presente trabalho relata o caso de uma cadela sem raça definida, adulta, com deformidade na região distal do membro torácico esquerdo, a qual consistia de duplicidade do osso acessório do carpo, aplasia do primeiro carpiano, ausência dos ligamentos interósseos entre o terceiro e o quarto dígitos, alterações ósseas no quarto dígito e presença de um dígito supranumerário incompleto adjacente ao quarto dígito. Após análise dos defeitos concluiu-se tratar de uma malformação congênita, hereditária em cães, denominada ectrodactilia, associada à existência de um dígito supranumerário.This paper describes a case of an adult mongrel bitch with a deformity in the distal area of the left forelimb, which was based on duplicity of the accessory carpal bone, aplasia of the first carpal bone, nonexistence of the interosseus ligament between digits 3 and 4, bony alterations in digit 4 and presence of an incomplete supernumerary digit adjacent to digit 4. After analysis of defects it was concluded to be a hereditary congenital malformation named ectrodactyly, associated to the existence of a supernumerary digit.

  12. Prenatal diagnosis of bilateral ectrodactyly and radial agenesis associated with trisomy 10 mosaicism.

    Science.gov (United States)

    Lévy, Jonathan; Jouannic, Jean-Marie; Saada, Julien; Dhombres, Ferdinand; Siffroi, Jean-Pierre; Portnoï, Marie-France

    2013-01-01

    Ectrodactyly or split hand and foot malformations (SHFMs) are rare malformations of the limbs, characterized by median clefts of the hands and feet, syndactyly, and aplasia and/or hypoplasia of the phalanges. They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. Bilateral radial ray defects comprise also a large heterogenous group of disorders, including trisomy 18, Fanconi anemia, and thrombocytopenia-absent-radius syndrome, not commonly associated with ectrodactyly. The present paper describes a case of ectrodactyly associated with bilateral radial ray defects, diagnosed in the first trimester of pregnancy, in a fetus affected by trisomy 10. Only four cases of sporadic and isolated ectrodactyly, diagnosed by ultrasonography between 14 and 22 weeks' gestation, have been reported. To our knowledge, the present case is the first report of mosaic trisomy 10 associated with SHFM and radial aplasia. Trisomy 10 is a rare lethal chromosomal abnormality, most frequently found in abortion products. Only six liveborn mosaic trisomy 10 infants, with severe malformations, dead in early infancy, have been reported. A severe clinical syndrome can be defined, comprising ear abnormalities, cleft lip/palate, malformations of eyes, heart, and kidneys, and deformity of hands and feet and most often associated with death neonatally or in early infancy. PMID:23401811

  13. SOS français : Conception et évaluation d’un didacticiel d’aide à la rédaction interactif

    Directory of Open Access Journals (Sweden)

    Gerard Laetitia

    2012-07-01

    Full Text Available L’objectif de la présente contribution est double. D’une part, nous présentons un nouveau didacticiel d’aide à la rédaction destiné à des apprenants de français langue étrangère ou seconde, SOS français, que nous situons par rapport aux correcteurs orthographiques et grammaticaux existants. SOS français fournit un contrôle de texte axé sur les principaux items orthographiques, grammaticaux et lexicaux réputés difficiles et sources d’erreurs fréquentes et récurrentes. Il se caractérise par un feedback très développé destiné à aider les apprenants à développer leurs compétences langagières. Une description grammaticale est également intégrée. Un deuxième volet de notre contribution est consacré à une étude d’efficacité. Nous y posons trois questions de recherche, portant sur l’efficacité de SOS français lors de la correction de textes, sur l’impact que peut avoir un tel outil sur la maîtrise du français à court et à moyen terme et sur la corrélation entre l’efficacité de l’aide et le type d’item grammatical. Nous avons pour cela mis en place une étude auprès de quelque 200 étudiants de première année universitaire. Dans la contribution, nous présentons la méthodologie suivie et les tout premiers résultats de cette étude, qui montrent l’intérêt de ce type d’outil tout en confirmant les constatations faites dans d’autres études quant à la difficulté de corriger les problèmes de grammaire.

  14. L’apport d’exercices en voix chantée pour la correction phonétique en langue étrangère : le cas du français langue étrangère appliqué à des apprenants italiens d’âge adulte

    OpenAIRE

    CORNAZ, Sandra; Henrich, Nathalie; Vallée, Nathalie

    2014-01-01

    Divers travaux ont établi que la musique favorise le processus acquisitionnel. En didactique des langues, le rôle positif de la chanson sur la perception des éléments prosodiques est bien connu et il a d’ailleurs été récemment montré que la reconnaissance syllabique d’une langue étrangère est facilitée par le chant. Des investigations de terrain menées en 2006 à l’Université Stendhal de Grenoble ont révélé l’efficacité de la voix chantée pour la correction phonético-phonologique du français l...

  15. L’apport d’exercices en voix chantée pour la correction phonétique en langue étrangère : le cas du français langue étrangère appliqué à des apprenants italiens d’âge adulte Using singing exercises as a tool for improving phonetic correction in foreign language teaching and learning: the case of French as a foreign language for native adult speakers of Italian

    OpenAIRE

    Nathalie Vallée; Nathalie Henrich; Sandra Cornaz

    2012-01-01

    Divers travaux ont établi que la musique favorise le processus acquisitionnel. En didactique des langues, le rôle positif de la chanson sur la perception des éléments prosodiques est bien connu et il a d’ailleurs été récemment montré que la reconnaissance syllabique d’une langue étrangère est facilitée par le chant. Des investigations de terrain menées en 2006 à l’Université Stendhal de Grenoble ont révélé l’efficacité de la voix chantée pour la correction phonético-phonologique du français l...

  16. L'Intelligence Compétitive 2.0 pour le pilotage des projets e-Marketing

    OpenAIRE

    Bruyère, Sébastien

    2010-01-01

    Ce projet de recherche appliquée a été initié afin d'optimiser la mesure et le pilotage de la performance e-Marketing dans un contexte évolutif lié aux mutations perpétuelles du Web (réseaux sociaux, Web 2.0 ...) et des modèles d‟affaires associés. Il vise à identifier des solutions organisationnelles et technologiques pour pallier aux difficultés rencontrées par l'équipe e-Marketing de l'agence interactive BleuRoy.com (groupe HighCo) tout en optimisant l'efficacité et la rentabilité des acti...

  17. L'utilité pour la continuité de la recherche clinique et des soins de santé primaire, des systèmes d'information scientique

    OpenAIRE

    Wulff Barreiro, Enrique; Rodríguez del Castillo, Mercedes

    2009-01-01

    OBJECTIFS: Le but principal de cette enquête est de bien connaître tant l'efficacité comme les limites découlant des systèmes d'informationscientifique, dans le cadre de la coordination et la continuité entre la recherche clinique et en matière de santé primaire, c'est-à-dire,dans la mise en oeuvre des résultats de la recherche à la pratique des soins. Pour ce faire, le deuxième but est l'évaluation de tendancesen matière de publications au cours de la période comprise entre 2002 et 2007.MÉTH...

  18. La G.R.H. : tentative d’application à une collectivité locale, la commune de Jette

    OpenAIRE

    Paul-Marie Empain

    2012-01-01

     « Au commencement était la modernisation … », à moins que ce ne soit la motivation … ? Suite aux assauts violents que connut l’organisation bureaucratique au cours des années 80, le paradigme à la mode les rendit indissociables. Les résultats d'une enquête internationale ont révélé les attentes principales des citoyens sont : l’efficacité et la productivité (83 %), la qualité du service (77 %) et la transparence (70 %). Pour les collectivités locales, dont la spécificité sera montrée dans l’...

  19. L’usage de l’argumentation en publicité

    OpenAIRE

    Desîlets, Christian; Gauthier, Gilles

    2014-01-01

    Les professionnels de la publicité désignent par les locutions « argument publicitaire » ou « argument de vente » tout aspect du message ayant pour fonction de le livrer avec efficacité. L’a priori des auteurs est que cette conception très large est inadéquate en ce qu’elle ne permet pas de rendre compte de la spécificité de l’argumentation en publicité. Leur objectif est de cerner techniquement ce qu’est un argument publicitaire et, plus largement, l’usage de l’argumentation en publicité. Le...

  20. Evaluation de la performance et de l'impact de la veille

    OpenAIRE

    Bezençon, Christophe; Roulet, Aurélie; Madinier, Hélène

    2014-01-01

    Ce travail de recherche, réalisé dans le cadre du Master en Information documentaire de la Haute école de gestion de Genève, développe, dans un premier temps, une réflexion sur la mesure de l’efficacité et l’impact de la veille issue de la littérature sur le sujet et d’entretiens menés auprès de praticiens. Dans un second temps, il propose une version bêta d’un outil générique permettant de mettre en place ce type de mesures par une cellule de veille. L’état de l’art, basé tant sur la littéra...

  1. ETUDE ENERGETIQUE DE CHAUFFAGE, RAFRAICHISSEMENT ET EAU CHAUDE SANITAIRE D’UNE MAISON TYPE EN ALGERIE.

    OpenAIRE

    KHARCHI, RAZIKA

    2014-01-01

    Le bâtiment à haute efficacité énergétique est la seule solution afin de diminuer les dépenses énergétiques et les émissions des gaz à effet de serre. Ce travail consiste à étudier le comportement thermique et énergétique d’une maison construite avec des matériaux locaux et selon les normes algériennes de construction. Une bonne isolation de l’enveloppe ainsi que le double vitrage sont appliqués sur l’habitat étudié. La méthode des degrés jours est utilisée pour l’analyse de la...

  2. Le bruit urbain : encore du travail en perspective

    OpenAIRE

    Vincent, B.; Lambert, J.; Vallet, M.

    2004-01-01

    Le bruit urbain, qui existe depuis tous temps et qui est considéré comme plus ou moins inévitable, n'est pas très bien pris en compte par les réglementations en vigueur. Cependant des tentatives de réduction du bruit urbain ont été appliquées : zones 30, revêtements absorbants, journée sans voitures : l'efficacité en est toutefois réduite. La directive européenne sur le bruit de l'environnement de 2002 va donner une nouvelle dimension au contrôle du bruit urbain, qui concerne une population i...

  3. Etude de la sensibilité de sexués de termites Macrotermitinae à une infestation par des nématodes entomopathogènes des genres Heterorhabditis et Steinernema

    OpenAIRE

    Rouland, C.; Ben Moussa, D.; Reversat, Georges; Laumond, C.

    1996-01-01

    Des termites sexués de 2 espèces de termites champignonnistes, #Pseudacanthotermes spiniger$ et #Ancistrotermes guineensis$, ravageurs de cultures tropicales, ont été utilisés pour tester l'efficacité de 3 souches de nématodes entomopathogènes des genres #Heterorhabditis$ et #Steinernema$. Un fort effet létal a été obtenu sur les 2 espèces quelle que soit la souche de nématodes utilisée, les nématodes du genre #Steinernema$ étant cependant les plus actifs. Pour la première fois chez un termit...

  4. Méthodologies de Conception Optimale des Composants Electromagnétiques

    OpenAIRE

    Gillon, Frédéric

    2009-01-01

    La conception des composants et systèmes électriques est en pleine évolution, poussée par les besoins sociétaux en terme d'environnement et d'efficacité énergétique. Notre société est basée sur une énergie bon marché et facilement accessible, ce que nous procure, entre autres, l'électricité. Les composants et systèmes électriques font partis de notre quotidien et permettent de faire fonctionner la totalité de nos moyens de production. Ils sont tellement présents, qu'ils pourraient presque pas...

  5. Dosimétrie électronique et métrologie neutrons par capteur CMOS a pixels actifs

    OpenAIRE

    Vanstalle, Marie

    2011-01-01

    Ce travail vise à démontrer la faisabilité d'un dosimètre opérationnel neutrons basé sur la technologie CMOS. Le capteur utilisé (MIMOSA-5) doit pour cela être transparent aux γ et pouvoir détecter les neutrons sur une large gamme d'énergie en gardant évidemment une bonne efficacité de détection. La réponse du système de détection, constitué du capteur CMOS adjoint d'un matériau convertisseur (polyéthylène pour les neutrons rapides, 10B pour les neutrons thermiques), a été confrontée à des si...

  6. Description des documents électroniques et les besoins des utilisateurs

    CERN Document Server

    Witt, M

    2001-01-01

    Pour évaluer, avec précision, la demande et les besoins en information, l'efficacité et la pertinence des informations, les usages qui en sont faits et le degré de satisfaction des usagers il faut, bien entendu, mener des études basées sur plusieurs méthodes. Malheureusement, je n ai pas à vous présenter de résultats d'enquêtes mais je vais en revanche faire quelques observations menées ponctuellement dans les bibliothèques publiques et évoquer l'état de l'accès aux documents électroniques dans les bibliothèques françaises. Je vais m'appuyer aussi sur les réflexions trouvées à ce sujet dans la littérature professionnelle, dont celle publiée en France.

  7. Comment protéger la santé des travailleurs dans un système qui ne repose pas sur les notions d’aptitude et d’inaptitude ? How to protect workers’ health in a system that is not based on the concepts of “capacity” and “incapacity” Cómo proteger la salud de los trabajadores en un sistema que no se basa en los conceptos de aptitud et ineptitud ?

    OpenAIRE

    Robert Plante; Luc Bherer; Michel Vézina

    2010-01-01

    Au Québec, en santé au travail, l’approche de santé publique a été privilégiée à l’approche médicale individuelle, parce qu’elle est conséquente aux objectifs de la loi, à savoir la prise en charge par le milieu de ses problèmes et la diminution, voire l’élimination des dangers. Quant aux activités médicales individuelles, elles ne sont réalisées que lorsqu’elles sont légitimes, c’est-à-dire lorsque leur pertinence et leur efficacité sur le plan de la prévention ont été démontrées. Quelques é...

  8. Des hystériques en mouvement : d’une assignation à une libération des corps ? Engagement des médecins et discours thérapeutiques dans la seconde moitié du XIXe siècle en France

    OpenAIRE

    Quin, Grégory; Bohuon, Anaïs

    2013-01-01

    Tout au long du XIXe siècle, une partie substantielle du champ médical se focalise sur cette « pathologie » aux contours troubles qu’est l’hystérie. Elle produit une littérature médicale, intéressante du point de vue de l’histoire des corps féminins en mouvement et de la manière dont les acteurs de l’époque mobilisent les « théories » biologiques - et donc du genre -, sur fond de métamorphoses de l’épistémologie médicale. Au sujet de l’hystérie, mouvements des corps et efficacité thérapeutiqu...

  9. Laraisonlointaine. Internet, rationalité encyclopédique et rationalité télématique

    OpenAIRE

    Quintili, Paolo

    2006-01-01

    La télématique et l’Internet impliquent une appréhension (màthesis) à distance (télé), qui contient des potentialités inconnues, dépassant de bien loin l’efficacité du livre électronique (CD Rom) non modifiable et plus rigide. L’appréhension télématique, tout en allégeant le travail de recherche, exige un effort d’intelligence inter- et métatextuelle qui met à l’abri des illusions de facilité que le virtuel suscite, avec ses « vices » (éliminer la lecture réelle). La rationalité télématique e...

  10. Broyage ultrafin de carbonates naturels‎ : Paramétrisation, modélisation et conséquences physico-chimiques

    OpenAIRE

    Clerc, Laurent

    1992-01-01

    163 pages No English abstract Ce travail sur le broyage micronique de la dolomie a permis d'étudier le comportement de deux nouveaux broyeurs: le broyeur RSK LAB 10-25 MATTER PARTNER à billes humides (broyeur à circulation forcée) et le broyeur alpine AFG 100-50 ATP (voie sèche à jets d'air). L'étude sur le broyage par voie humide a permis d'apprécier la grande efficacité de ce broyeur. Les paramètres essentiels sont la vitesse de rotation et le débit d'alimentation. Les granulométries ...

  11. Preclinical studies on a new strategy combining the Bacillus of Calmette-Guérin with plasmid DNA-based subunit vaccines against tuberculosis/Etudes précliniques sur une nouvelle stratégie de vaccination contre la tuberculose combinant le Bacille de Calmette-Guérin avec des vaccins à ADN plasmidique

    OpenAIRE

    Bruffaerts, Nicolas

    2015-01-01

    La tuberculose est une maladie contagieuse causée par les bactéries appartenant au complexe Mycobacterium tuberculosis. On estime près de neuf millions de nouveaux cas et un million de décès chaque année dans le monde. De plus, approximativement un tiers de la population mondiale est infecté de manière latente, donc à risque de développer la maladie. Le seul vaccin préventif jusqu’à présent disponible est le Bacille de Calmette-Guérin (BCG). Cependant, son efficacité contre la forme pulmonair...

  12. Identifier les déficiences énergétiques des bâtiments du Service de l’Agriculture du Canton du Valais (SCA)

    OpenAIRE

    Bagnoud, Maxime; Imboden, Serge

    2014-01-01

    Le but de ce travail est d’améliorer le rapport à la norme ISO 14'001. Cette dernière est basée sur l’environnement et l’écologie. Je vais donc trouver les éléments produisant les plus grosses pertes des bâtiments et proposer des solutions pour améliorer l’efficacité énergétique. De ce fait, la consommation d’énergie fossile, soit du gaz naturel, sera diminuée. De plus, je vais me pencher sur les différentes solutions de remplacement de chauffage afin de diminuer cette consommation et essayer...

  13. Modélisation de la faillite d'exploitations agricoles : comparaison de méthodes de régression non linéaire avec R

    OpenAIRE

    Laurent, Thibault

    2009-01-01

    L'idée de cet article est d'essayer des méthodes de régression non paramétriques pour le ``scoring'' et de vérifier leur efficacité en terme de taux de mal classés. Les méthodes approchées sont le modèle additif généralisé introduit par Hastie et Tibshirani (1986), le bagging et les forêts aléatoires proposés par Breiman~(1996, 2001). On essaira également les Support Vecteur Machines proposés par Vapnik (1999). Nous poursuivons les travaux de Desbois (2008) qui a modélisé les probabilités de ...

  14. Établissement d’un critère de qualité des taillants diamant/WC-Co pour l’excavation de formations rocheuses

    OpenAIRE

    Yahiaoui, Malik; Gerbaud, Laurent; Paris, Jean-Yves; Delbé, Karl; Denape, Jean; Dourfaye, Alfazazi

    2012-01-01

    Sous des conditions géologiques extrêmes, les outils de forage composés d’inserts en diamant polycristallins (PDC) sont particulièrement intéressants au vu de leur performance de coupe [1]. La qualité des matériaux innovants utilisés pour la fabrication de ces outils PDC doit être déterminée avec précision par la mesure de leur efficacité de coupe et de leur résistance à l’usure. Un banc d’usure (tour) composé de roches formées par un mortier spécifique a été utilisé pour réaliser les expérie...

  15. Lutte contre les nématodes a galles : test de différents engrais verts nématicides : compte-rendu d'essai 2005

    OpenAIRE

    Védie, Hélène; Geffroy, Thomas; Lambion, Jérôme

    2006-01-01

    Différents engrais verts sont réputés pour leur propriétés nématicides. Le GRAB a étudié plusieurs espèces : crotalaires (en partenariat avec l'IRD de Montpellier), Tagetes patula et minuta, Mucuna, dont l’efficacité se heurte souvent à des problèmes de réalisation technique, notamment de concurrence avec les adventices. L’objectif du présent essai est d’évaluer : - la faisabilité de nouvelles espèces d’engrais verts sélectionnées dans la bibliographie. Il s’agit de voir si les espèces ret...

  16. Politiques publiques de développement à la frontière franco-brésilienne : une ignorance mutuelle

    OpenAIRE

    d’Hautefeuille, Madeleine Boudoux

    2013-01-01

    De nombreux espaces frontaliers périphériques des États nationaux font l’objet, de par le monde, de politiques publiques de développement territorialisées. La frontière franco-brésilienne, entre la Guyane française, département-région d’outre-mer français, et l’Amapá, État fédéré brésilien, constitue le cas d’étude sur lequel nous examinons ici ces politiques en nous intéressant non à leur efficacité mais à leur coïncidence. Cet examen révèle un différentiel politique majeur entre France et B...

  17. Socio-Economic impacts of the deployment of improved Fuel Efficient Stoves: the ILF Uganda Commercialization Program

    OpenAIRE

    Wiedmer, Damien; Jouslin-de-Noray, Pauline; Graveaud, Fabiola; Jahangiri, Vahid

    2015-01-01

    La biomasse représente 91 % de l'énergie totale utilisée en Ouganda, mais elle est souvent utilisée de façon non durable. Si la déforestation se poursuit au rythme actuel, elle pourrait conduire à la destruction de toutes les forêts ougandaises d'ici 2050. En conséquence, le bois et le charbon de bois sont de plus en plus rares et leur prix augmente. Les cuisinières à haute efficacité énergétique sont un moyen de s'attaquer à ces questions en diminuant la quantité de biomasse utilisée pour la...

  18. Modélisation et automatisation des procédés d’écriture et de production de supports de formation numérisés - Le modèle M.A.Ï.HEU.T.I.C. de la CCI de Paris

    OpenAIRE

    José Martin

    2005-01-01

    [Français] Cet article expose les conclusions d’un projet de recherche de la Direction de l’Enseignement de la Chambre de Commerce et d’Industrie de Paris (CCIP), mené de 2003 à 2005, dont l’aboutissement est un modèle didactique de production de contenus de cours numérisés, baptisé M.A.Ï.HEU.T.I.C. (Modèle Appliqué d’Interprétation Heuristique des Technologies de l’Information et de la Communication). Ce modèle recherche l’efficacité formative par une articulation didactique des contenus, do...

  19. La gestion des populations. Intérêt possible des biotechnologies de l’embryon pour la sélection des bovins laitiers

    OpenAIRE

    Colleau, J Jacques

    1992-01-01

    Les effets possibles d’une utilisation de la transplantation embryonnaire dans les schémas de sélection des bovins laitiers sont décrits. La perspective est étendue au cas de l’utilisation d’embryons sexés ou sexés et clonés bien que les techniques correspondantes soient encore en cours de développement. Ces effets sont décrits en termes de génétique des populations où plusieurs paramètres très différents contribuent à l’efficacité globale des programmes de sélection. Leur résultat net est qu...

  20. Virtual Composition of EMF Models

    OpenAIRE

    Clasen, Cauê; Jouault, Frédéric; Cabot, Jordi

    2011-01-01

    La composition de modèles est une tâche de modélisation très importante car elle permet de combiner différents points de vue d'un système (qui est représenté par divers modèles) en une seule vue spécialisée (un modèle composé). Plusieurs approches ont été proposées pour aborder ce problème, mais elles présentent d'importantes limitations concernant l'efficacité, l'interopérabilité, et/ou les problèmes de synchronisation (principalement en raison du mécanisme de clonage d'éléments utilisé pour...

  1. La place du droit du travail dans la lutte contre la pauvreté

    OpenAIRE

    Reis, Patrice

    2006-01-01

    PLAN I) Le respect des droits fondamentaux au travail, socle du droit à un travail décent. A) Une affirmation incomplète des droits sociaux fondamentaux 1) Les droits sociaux fondamentaux consacrés par l'organisation internationale du travail. 2) Des droits sociaux fondamentaux à réaffirmer et à promouvoir B) L'absence d'efficacité des mécanismes de contrôle. 1) L'inefficacité de l'OIT. 2) Le reflux des contrôles effectués par les autorités publiques. II) Le dépassement des droits sociaux fon...

  2. Stratégies d'optimisation mixte en Génie des Procédés – Application à la conception d'ateliers discontinus

    OpenAIRE

    Ponsich, Antonin

    2005-01-01

    La conception d'ateliers discontinus implique généralement la résolution de problèmes d'optimisation non-linéaire en variables mixtes. L'objectif de ce travail est de proposer une méthodologie adaptée pour leur traitement en évaluant les performances de deux méthodes déterministes de l'environnement GAMS et un algorithme génétique (AG), sur un jeu d'exemples de complexité croissante. Avec la formulation de Programmation Mathématique retenue, les résultats numériques vérifient l'efficacité de ...

  3. Dépistage de la consommation d’alcool et intervention brève parmi des patients dépendants aux opiacés et à la cocaïne : étude contrôlée et randomisée

    OpenAIRE

    Feldman, Nelson

    2013-01-01

    Cette recherche clinique décrit la prévalence de la consommation d’alcool parmi des patients en traitement ambulatoire pour dépendance aux opiacés et à la cocaïne dans le Service d’Addictologie des HUG avec l’utilisation de l’AUDIT et évalue l’efficacité de l’Intervention Brève chez les buveurs excessifs et les patients alcoolo-dépendants. Les sujets inclus dans cette étude étaient 254 patients toxicodépendants entre 2003 et 2005. Cette étude a montré une prévalence élevée (44%) de la consomm...

  4. L’outarde et le TGV : une controverse sur les compensations pour atteintes à la biodiversité

    OpenAIRE

    Vandevelde, Jean-Christophe

    2013-01-01

    Le principe de compensation des atteintes à la biodiversité consiste pour les aménageurs à rembourser leur « dette » résiduelle de biodiversité constituée par les impacts de leur projet, après qu’ils aient mis en œuvre des actions pour éviter et réduire au maximum ces impacts. Néanmoins, la réalisation concrète de ces compensations est chargée d’incertitudes quant à leur efficacité réelle et les compensations sont devenues un objet de controverses. L’examen des différentes phases d’une contro...

  5. Traitement de l’ambiguïté dans les logiciels de traduction automatique en ligne

    Directory of Open Access Journals (Sweden)

    Jean Ntakirutimana

    2010-05-01

    Full Text Available Il existe de nos jours plusieurs logiciels de traduction automatique et bon nombre d’entre eux sont accessibles sur l’internet. Ainsi, des moteurs de recherche comme AltaVista ou Yahoo proposent aux internautes d’afficher les pages Web cibles en versions traduites instantanément dans la langue de choix de l’utilisateur. À l’instar d’autres gadgets issus des nouvelles technologies de l’information et de la communication (NTIC, les logiciels de traduction automatique sont largement utilisés partout dans le monde, et certains utilisateurs ne s’interrogent même pas sur l’efficacité réelle de ces nouveaux outils langagiers. L’on comprend alors pourquoi la traduction automatique génère ci et là, et de façon quasi anodine, des perles langagières du genre.

  6. Les régimes internationaux de l’environnement

    Directory of Open Access Journals (Sweden)

    Jean-Frédéric Morin

    2015-01-01

    Full Text Available Le concept de « régime international » est utilisé dans tous les domaines des relations internationales. C’est néanmoins en politique internationale de l’environnement qu’il connaît le plus d’écho et qu’il semble le plus fécond. Il permet de rendre compte à la fois de la prolifération exceptionnelle du nombre d’accords multilatéraux sur l’environnement et de l’absence d’organisation multilatérale qui chapeauterait tous ces accords. Cet article passe en revue les débats sur la signification, l’émergence, le développement et l’efficacité des régimes environnementaux internationaux.

  7. Individual Responsibility and the Funding of Collective Goods

    OpenAIRE

    Lévy-Garboua, Louis; Montmarquette, Claude; Villeval, Marie Claire

    2007-01-01

    Un déficit dans le financement d'un bien collectif est généralement couvert soit par un accroissement des impôts, soit par un rationnement des usagers. Cet article compare l'efficacité de ces institutions. Nous présentons les résultats d'une expérience de laboratoire qui s'appuie sur un jeu dans la première étape duquel les sujets peuvent contribuer volontairement au financement d'un bien collectif destiné à indemniser les victimes d'un dommage. Dans la deuxième étape du jeu, en cas de défici...

  8. Développement de nouveaux bétons ''accumulateurs d'énergie'' : investigations expérimentale, probabiliste et numérique du comportement thermique

    OpenAIRE

    Drissi, Sarra

    2015-01-01

    A l'heure actuelle, les nouvelles contraintes de la réglementation thermique en vigueur ne cessent de s'adapter au contexte économique global pour lequel la recherche d'une efficacité énergétique dans le bâtiment est devenue incontournable. Pour répondre à ces défis, des Matériaux intelligents à Changement de Phase (MCP) ont fait leur apparition sur le marché de la construction. Grâce à leur capacité de stockage de l'énergie, les MCP sont de plus en plus associés aux matériaux de construction...

  9. Evaluation du probiotique bactérien Pediococcus acidilactici MA18/5M chez la crevette pénéide Litopenaeus stylirostris en Nouvelle- Calédonie

    OpenAIRE

    Castex, Mathieu

    2009-01-01

    Pediococcus acidilacticii MA18/5M est un probiotique bactérien (BACTOCELL®) qui a démontré son efficacité chez plusieurs espèces d'animaux terrestres et aquatiques. Cette thèse avait pour objectif d'investiguer plus en détails les effets de ce probiotique chez les crevettes pénéides d'élevage. Pour cette étude, nous avons choisi une approche globale replaçant la problématique dans un modèle d'interactions entre trois compartiments : la crevette, sa microflore intestinale et le probiotique. Ap...

  10. Le bois raméal fragmenté (BRF) en végétalisation pour la lutte contre l'érosion de surface

    OpenAIRE

    Rey, F.; Breton, V; Meistermann, S.; Crosaz, Y.

    2009-01-01

    / L'érosion de surface constitue un phénomène naturel aux conséquences souvent préoccupantes et dommageables. Si la végétation peut jouer un rôle très efficace de protection des sols contre l'érosion, les conditions de milieu ne permettent pas toujours son bon développement. L'une des pistes entrevues serait d'utiliser le Bois Raméal Fragmenté (BRF). L'objectif de ce projet était de déterminer l'efficacité de ce matériau pour : 1/ la lutte contre l'érosion en contexte torrentiel ; 2/ la facil...

  11. Sociologie de la star et plaisir cinématographiqueEnquête sur les films de Sarah Bernhardt

    OpenAIRE

    Leveratto, Jean-Marc

    2014-01-01

    L’article s’efforce de dépasser les limites de l’approche sociologique traditionnelle de la star en France en s’intéressant au processus d’émergence du star-system cinématographique dans les années 1910 à travers la naissance du feature film. L’observation de la réception des films de Sarah Bernhardt aux Etats-Unis, la confrontation du discours critique porté sur la performance de la star en France et aux Etats-Unis, autorise une analyse sociologique de l’efficacité esthétique de la star pren...

  12. Photosynthetic characteristics of five high light and low light exposed microalgaea as measured with 14C-uptake and oxygen electrode techniques

    OpenAIRE

    Grobbelaar, J.U.; Schanz, F.; Dubinsky, Z.; M. M. Tilzer; Burger-Wiersma, T; Rijkeboer, M.; Lemoalle, Jacques; Falkowski, P. G.

    1992-01-01

    #Tetraselmis suecica$, #Thalassiosira pseudonana$, #Chaetoceros calcitrans$, #Isochrysis galbana$ et #Microcystis sp.$ ont été utilisées pour déterminer leurs capacités d'adaptation et pour tester les différences entre les deux méthodes de mesure. Les cultures avaient été exposées à un éclairement fort (HL) ou à un éclairement faible (LL) pendant deux jours avant l'expérience. L'efficacité de la conversion de la lumière (...) et l'activité photosynthétique spécifique maximale par unité de chl...

  13. Quelle ergonomie pour la pratique postéditrice des textes traduits ?

    OpenAIRE

    Brunette, Louise; O’Brien, Sharon

    2011-01-01

    Peu importe ce que l’étiquette postédition a désigné depuis 30 ans, cette pratique traductive n’a jamais fait l’objet d’études à caractère ergonomique. À ce jour, seule a importé l’efficacité mesurable de l’opération. On peut se risquer à dire que c’est là d’ailleurs l’histoire de toute l’informatisation de la traduction, qui s’est faite sans consultation des traducteurs, à de rares exceptions près. Dans l’optique de l’intégration des postéditeurs dans la chaîne de production des logiciels ou...

  14. Le tubage gastrique chez les poissons : mise au point d'un équipement et test chez le chabot Cottus gobio L.

    OpenAIRE

    GAUDIN P.; Martin, E.; CAILLERE L.

    1981-01-01

    Un système de vidange stomacale a été mis au point dans le but de préciser le régime alimentaire d'une petite population de chabots (Cottus gobio L.). Le matériel et les principes d'utilisation sont décrits. La méthode a été testée au laboratoire et sur le terrain. L'expérimentation réalisée au laboratoire montre que : 1 — l'efficacité de la vidange stomacale est très satisfaisante (98,2 % ) , 2 — le taux de réalimentation est très élevé 24 heures après la vidange, 3 — la survie, un mois aprè...

  15. Caractérisation du système Himawari du vivarium Elapsoidea de Meyrin

    OpenAIRE

    Ineichen, Pierre; Pampaloni, Eric; Bouvier, S

    1994-01-01

    Les mesures que nous avons effectuées sur le système Himawari durant une période restreinte de 2 semaines ont donné les résultats suivants: le système fonctionne de façon satisfaisante en cas de bon ensoleillement, avec une efficacité globale de 14% (le fabricant donne 28%), sur la période étudiée, la poursuite du soleil s'est faite correctement, la dispersion entre les mesures effectuées par le système et celles effectuées par notre chaîne en ville de Genève est de 3.3% pour de beaux jou...

  16. Étude du pamphlet luthérien du prêtre-imprimeur Sebastián Martínez. Texte et contexte d’un écrit hérétique (Tolède, septembre 1559)

    OpenAIRE

    Saez, Ricardo

    2016-01-01

    Le présent article repose sur un pamphlet antipapiste, daté du mois de septembre 1559, répandu, tout d’abord, dans les rues de Tolède et, ultérieurement, dans celles d’Ávila et de Séville. Son intérêt tient, sans nul doute, non plus à la répression que l’Inquisition espagnole a déployée avec une redoutable efficacité contre les mouvements hérétiques modernes mais au constat que, contrairement à l’illuminisme et à l’érasmisme, le luthéranisme est une hérésie érigée, désormais, en Église. L’étu...

  17. La récupération des terres dégradées: un enjeu socio-environnemental prioritaire en Amazonie brésilienne

    OpenAIRE

    Richard Pasquis; Luciana de Oliveira Machado

    2007-01-01

    L’Amazonie est connue pour ses taux alarmants de déforestation. Le plus dramatique est que la forêt laisse place à des systèmes extensifs répondant le plus souvent à une stratégie essentiellement foncière. Cette stratégie à un coût. Les terres dégradées, abandonnées, ou sous-utilisées atteignent maintenant 25% des espaces défrichés. Alors que les méthodes classiques de contrôle de la déforestation n’ont montré aucune efficacité, paradoxalement, la récupération et l’intensification de ces terr...

  18. Lutte biologique contre le papillon palmivore (Paysandisia archon) à l'aide de parasitoïdes oophages

    OpenAIRE

    Cabrol, Bastien; Colombel, Etty; Buradino, Maurane; GAGLIO, Jean Claude; Martin, Jean Claude,; Tabone, Elisabeth

    2014-01-01

    Originaire d’Argentine, le papillon palmivore Paysandisia archon (Burmeister) poursuit sa progression en région méditerranéenne en entrainant des dégâts considérables sur les palmiers et des pertes économiques importantes. Il est donc urgent de trouver une solution biologique pour contrôler ce ravageur, en respectant l’environnement et la santé humaine. Les trichogrammes, dont l’efficacité a déjà été prouvée en lutte biologique sur différentes cultures, ont été testés au laboratoire et sur le...

  19. Développement d'un programme de lutte biologique contre le ravageur du palmier Paysandisia archon à l'aide de parasitoïdes oophages

    OpenAIRE

    Cabrol, Bastien; Colombel, Etty; Buradino, Maurane; GAGLIO, Jean Claude; Martin, Jean Claude,; Tabone, Elisabeth

    2014-01-01

    Originaire d'Argentine, le papillon palmivore Paysandisia archon (Burmeister) poursuit sa progression en région méditerranéenne en entrainant des dégâts considérables sur les palmiers et des pertes économiques importantes. Il est donc urgent de trouver une solution biologique pour contrôler ce ravageur, en respectant l'environnement et la santé humaine. Les Trichogrammes, dont l'efficacité a déjà été prouvée en lutte biologique sur différentes cultures, ont été testés au laboratoire et sur le...

  20. Operational Models for Improving the Targeting Efficiency of Development Policies: A Systematic Comparison of Different Estimation Methods Using Out-of-sample Tests

    OpenAIRE

    Nazaire Houssou; Manfred Zeller

    2012-01-01

    Selon une croyance de longue date, un ciblage précis des pauvres peut améliorer l′efficacité des politiques de développement. Alors qu′un certain nombre de facteurs, tels que la mauvaise gouvernance, les méthodes de ciblage inadéquates, l′ingérence ou le manque de volonté politique, peuvent expliquer le faible taux de ciblage des programmes de développement, cet article cherche à améliorer les modèles conçus à partir d'indicateurs socio-économiques pouvant identifier plus précisement des ména...

  1. Effet d'un bombardement ionique de très basse énergie sur la barrière de Schottky métal-GaAs

    OpenAIRE

    Neffati, T.; Barret, C.; Lu, G.N.; Maaref, H.

    1988-01-01

    Une étude systématique du comportement électrique de diodes Schottky obtenues par évaporation d'aluminium et d'or sur GaAs de type N nettoyé par bombardement ionique dans la gamme d'énergie 0-200 V est effectuée. Les principaux résulats sont que : i) La barrière de Schottky décroît lorsque l'énergie des ions augmente et devient indépendante du métal déposé. ii) L'efficacité d'un traitement thermique postmétallisation pour restaurer la barrière initiale décroît lorsque l'énergie des ions augme...

  2. Etude de la flore bactérienne contaminant les téléphones mobiles avant et après la désinfection: comparaison entre les professionnels soignants de l'hôpital militaire d'instruction Mohammed V de Rabat et les témoins

    OpenAIRE

    Uwingabiye, Jean; Moustanfii, Wafaa; Chadli, Meryem; Sekhsokh, Yassine

    2015-01-01

    Introduction L'objectif de notre travail était évaluer la contamination microbienne des téléphones mobiles utilisés par les personnels soignants des différents services de l'hôpital militaire d'instructions Mohammed V de Rabat et la comparer à celui d'une population témoin et aussi démontrer l'efficacité des solutions hydroalcoolique dans la désinfection de ces téléphones mobiles. Méthodes Il s'agit d'une étude descriptive transversale réalisée sur une période de 9 mois entre septembre 2010 e...

  3. : FRACTALOPOLIS MODEL - ACCESSIBILITY, EVALUATION & MORPHOLOGICAL RULES

    OpenAIRE

    Czerkauer-Yamu, Claudia; Frankhauser, Pierre

    2012-01-01

    Une stratégie d'aménagement durable représente un enjeu important pour le développement des agglomérations contemporaines. L'aménagement durable implique le développement de stratégies visant à réduire l'utilisation des ressources, accroître l'efficacité économique et améliorer l'intégration des aspects sociaux (ex. environnements conviviaux pour les piétons, équilibre entre modes de transport public/privé, réseaux routiers performants, viabilisation des terres agricoles, économie du mouvemen...

  4. Les comités de santé et de sécurité dans les petites entreprises multiethniques de Montréal

    OpenAIRE

    Legendre, Gabrielle; Gravel, Sylvie; Rhéaume, Jacques

    2014-01-01

    Il existe une littérature importante sur les comités de santé et de sécurité (CSS) et leur efficacité, toutefois aucune étude ne s’est intéressée aux CSS dans les petites entreprises (PE) multiethniques, et ce, malgré l'importance de ces dernières dans les métropoles comme Montréal. Le présent article traite des facteurs favorisant la présence et le fonctionnement des CSS dans les PE multiethniques de Montréal. Des entrevues auprès des responsables de la SST de 28 PE montréalaises et avec les...

  5. Audit énergétique du Centre sportif de Combremont de la commune de Riddes

    OpenAIRE

    Briguet, Lionel; Genoud, Stéphane

    2016-01-01

    L’objectif de ce travail est la réalisation d’un audit énergétique du Centre sportif de Combremont à Riddes. Le but étant d’analyser les consommations électriques et thermiques de l’établissement en vue d’apporter des recommandations d’amélioration de l’efficacité énergétique. Tout d’abord, une analyse de l’éclairage du site sera effectuée. Puis, les déperditions thermiques de l’enveloppe de la bâtisse seront déterminées. Une observation des différentes installations techniques sera fait...

  6. Introduction et utilisation des TIC dans les PME tunisiennes

    OpenAIRE

    Chaabouni, Jamil; Zghal, Riadh

    2014-01-01

    Les technologies de l’information et de la communication (Tic) sont présentées par de nombreux auteurs comme une opportunité qui permettrait aux entreprises de l’« ancienne économie » (old economy) d’accroître leur efficacité et leur efficience. Le concept de « nouvelle économie » (new economy) dont l’origine est boursière, se base en partie sur une croissance forte de la productivité et des profits (P. Löpfe, 2001). R. Ergenzinger et J. S. Krulis-Randa (2001, 88) relèvent que old economy et ...

  7. Lutter contre l'éjaculation précoce

    OpenAIRE

    Kempeneers, Philippe; Bauwens, Sabrina; Andrianne, Robert

    2015-01-01

    Aujourd’hui, environ un homme sur cinq se plaint d’éjaculer trop rapidement. Face à ce constat, les auteurs ont rédigé un guide pratique, le premier publié en langue française dont l’efficacité à été démontrée par des études cliniques. Cet ouvrage peut être assimilé à un véritable traitement car il offre à tous les hommes et à tous les couples confrontés à ce problème, des information et des conseils afin de tenter d’y remédier. Ce guide intéressera également les intervenants en santé sou...

  8. UNE APPROCHE TECHNOLOGIQUE D'AUTOEVALUATION FORMATIVE EN COMPTABILITE : D'UNE LOGIQUE DE TRANSMISSION DE CONNAISSANCES COMPTABLES A UNE LOGIQUE DE DEVELOPPEMENT DE COMPETENCES EN COMPTABILITE.

    OpenAIRE

    Montalan, Marie-Annick

    2002-01-01

    International audience La recherche de l'efficacité de l'individu par l'amélioration de sa compétence professionnelle ne peut être dissociée de celle de l'amélioration de la formation de cette compétence. La démarche retenue consiste à faire de la compétence le principe organisateur et régulateur d'une formation centrée évaluation et à recourir aux technologies de l'information et de la communication (TIC) pour penser un système d'auto-évaluation formative des compétences comptables. Cet a...

  9. Enherbement des sols : quels effets possibles sur le devenir environnemental des pesticides ?

    OpenAIRE

    Benoit, Pierre

    2010-01-01

    La synthèse des études en cours montre que la mise en place de surfaces en herbe (dans la rotation ou en tant que bandes enherbées) permet tout d’abord de réduire les quantités de pesticides utilisées à l’hectare et, par ailleurs, de réduire les transferts hors des parcelles agricoles, en retardant le déclenchement du ruissellement et en favorisant l’infiltration et la rétention des contaminants. Le risque pour les eaux souterraines peut également être réduit selon l’efficacité des processus ...

  10. Der Kluge reist im Zuge

    OpenAIRE

    Jaques, Pierre-Emmanuel

    2016-01-01

    L’efficacité du slogan Der Kluge reist im Zuge (et le fait qu’on s’en souvienne encore actuellement !), témoigne de l’inventivité des campagnes publicitaires menées par les Chemins de fer fédéraux. Encore aujourd’hui, les affiches et les spots publicitaires font preuve d’une recherche approfondie dans le marketing et la construction de l’image de cette entreprise. D’une part, on a fait appel à des artistes renommés pour certaines campagnes, d’autre part, on a établi des stratégies en vue d’at...

  11. Un nouvel outil de régulation de la pyrale du buis, Cydalima perspectalis (Walker): un kit piège et phéromone hautement attractif

    OpenAIRE

    Martin, Jean Claude; Brinquin, Anne Sophie; Morel, Estelle; Tabone, Elisabeth

    2015-01-01

    La pyrale du buis, Cydalima perspectalis (Walker), est un lépidoptère envahissant dont les chenilles sont responsables d'importants dégâts sur le buis. Pour cette première année du projet SaveBuxus, des test d'efficacité des pièges à lépidoptères ainsi que des test comparatifs d'attractivité des diffuseurs de phéromones sexuelles ont été effectués. Un prototype de piège mis au point par l'INRA, utilisable sans ajout d'eau, a également été testé ainsi que la persistance d'action du diffuseur l...

  12. Is employee ownership so senseless ?

    OpenAIRE

    Aubert, Nicolas; Bernard, Grand; Lapied, André; Rousseau, Patrick

    2009-01-01

    Depuis Enron et la ruine de milliers de ses employés, l'actionnariat salarié est critiqué. Investir son épargne en actions de son entreprise équivaudrait à parier sur un seul actif. De plus, l'efficacité contestée de l'actionnariat salarié ne justifierait pas que les entreprises distribuent des actions à leurs salariés. Pourtant, l'actionnariat salarié est adopté par des milliers d'entreprises et des millions de salariés à travers le monde. Cet article propose un modèle d'aléa moral où un ent...

  13. Synthèse d'observateurs d'ordre réduit, application à une éolienne

    OpenAIRE

    Ezzine, Montassar; Souley Ali, Harouna; Darouach, Mohamed; Messaoud, Hassani

    2009-01-01

    Nous appliquons, dans cet article, deux méthodes de synthèse d'observateurs d'ordre réduit à entrées inconnues pour estimer les états d'une éolienne. La première méthode est une approche temporelle où après avoir donné les conditions d'existence et de stabilité de l'observateur, nous donnons un algorithme de synthèse. Puis nous donnons l'algorithme concernant l'approche fréquentielle avant de montrer l'efficacité de ces deux méthodes sur un modèle d'éolienne.

  14. Prophylaxie de la maladie thromboembolique en soins palliatifs oncologiques: contexte général, étude clinique et difficultés de la recherche

    OpenAIRE

    Weber, Catherine; Zulian, Gilbert

    2006-01-01

    Le nombre de patients souffrant d'un cancer en soins palliatifs ne cesse d'augmenter. Pour que la prise en charge de ces patients soit optimale, la médecine palliative doit pouvoir être basée sur l'évidence à partir d'études cliniques. L'utilité d'une prophylaxie anti-thrombotique n'est actuellement pas prouvée chez ce type de patients. L'étude prospective SPOT, randomisée en simple aveugle, a pour but d'étudier l'efficacité, les risques et les effets secondaires de l'administration d'une hép...

  15. Prophylaxie de la maladie thromboembolique en soins palliatifs oncologiques : contexte général, étude clinique et difficultés de la recherche

    OpenAIRE

    Weber, Catherine

    2006-01-01

    Le nombre de patients souffrant d'un cancer en soins palliatifs ne cesse d'augmenter. Pour que la prise en charge de ces patients soit optimale, la médecine palliative doit pouvoir être basée sur l'évidence à partir d'études cliniques. L'utilité d'une prophylaxie anti-thrombotique n'est actuellement pas prouvée chez ce type de patients. L'étude prospective SPOT, randomisée en simple aveugle, a pour but d'étudier l'efficacité, les risques et les effets secondaires de l'administration d'une hép...

  16. La théorie de l'enrichissement cognitif à travers la stimulation physique : activité physique traditionnelle versus exergames

    OpenAIRE

    Maillot, Pauline; Perrot, Alexandra

    2012-01-01

    L'hypothèse de l'enrichissement cognitif suggère que l'ensemble des comportements et conduites adoptés par l'individu au cours de sa vie aurait un impact positif sur le niveau d'efficacité cognitive en avançant en âge. Cet article vise à argumenter ce concept en présentant des travaux réalisés dans le domaine de la stimulation physique. En effet, plusieurs études interventionnistes ont fait état d'améliorations cognitives chez des personnes âgées suite à une sollicitation physique, et ce, soi...

  17. Intelligence stratégique et dissimulation dans les outils de géovisualisation en ligne

    Directory of Open Access Journals (Sweden)

    Samuel Challéat

    2014-06-01

    Full Text Available Les portails de géovisualisation interactive, mis en place sur Internet à la suite de l'emblématique Google Maps, sont plébiscités par le public. Ils donnent à voir d'en haut la surface de notre planète, et plus spécifiquement du territoire français dans le cas du Géoportail. Pourtant, il est interdit de s'approcher trop près de certains objets: sur le territoire national, quelque 150 sites sont dissimulés par l'IGN. Nous questionnons ici la pertinence et l'efficacité de cette opération imposée au principal organisme de production et de diffusion d'informations géographiques en France, en comparaison avec les moyens mis en œuvre par d'autres pays.

  18. Lutte biologique contre la fusariose vasculaire de la tomate. Resultats en serre de production

    OpenAIRE

    COUTEAUDIER, Yvonne; Letard, M. (collab.); Alabouvette, Claude; Louvet, J.

    1985-01-01

    Les connaissances acquises au cours de l’étude de la résistance des sols de Châteaurenard ont permis d’élaborer en conditions expérimentales 2 méthodes de lutte biologique contre les fusarioses vasculaires. Après avoir obtenu de bons résultats en conditions expérimentales, l’efficacité de ces procédés a été testée dans une serre dont le sol est très infesté par Fusarium oxysporum f. sp. lycopersici. La première méthode consiste à mélanger à un sol préalablement traité à la chaleur une ter...

  19. CATEVA CONSIDERATII PRIVIND PRESIUNEA FISCALA ASUPRA AGENTILOR ECONOMICI

    OpenAIRE

    Anca Georoceanu

    2008-01-01

    L’évolution de la fiscalité est en liaison directe avec l’évolution de l’Etat et de ses fonctions; l’analyse de la notion de fiscalité est non seulement importante, mais aussi nécessaire, parce que, de la façon dont celle-ci est conçue et fonctionne, on peut tirer deux conclusions a l’égard de la pression fiscale, de la politique fiscale et de l’efficacité de l’implication du pouvoir public dans la vie économique et sociale d’une société. La fiscalité, en principe, a pour but la réalisation d...

  20. Stations de ski en crise et construction territoriale en Catalogne française

    OpenAIRE

    Vlès, Vincent

    2012-01-01

    L’efficacité de l’intercommunalité dans la reconversion de l’économie des territoires touristiques montagnards se prête particulièrement bien à une analyse en termes de gouvernance. Mettre l’accent sur les processus de négociation, de concertation, de coopération entre les sphères publiques, privées et les réseaux permet d’évaluer les liens de solidarité dans la gestion des crises, notamment lors de l’accompagnement du désarmement de petites stations de ski ou de leur adaptation à un hypothét...

  1. Une évaluation expérimentale des modes électroniques de résolution des litiges

    OpenAIRE

    Gabuthy, Yannick; Jacquemet, Nicolas

    2007-01-01

    Le développement très important de l'Internet et du commerce électronique s'est accompagné de l'émergence de modes électroniques de résolution des litiges. L'objectif du article est d'évaluer expérimentalement l'efficacité économique d'une procédure novatrice, la négociation électronique, qui intègre la technologie comme acteur actif dans le traitement des conflits : les propositions des parties sont reçues et évaluées par un logiciel informatique qui introduit un mécanisme de convergence dan...

  2. Conception d'Antenne Spirale intégrée sur SOI à 60 GHz

    OpenAIRE

    Barakat, Moussa; Delaveaud, Christophe; Dussopt, Laurent; Ndagijimana, Fabien

    2009-01-01

    La conception d'une antenne spirale intégrée sur SOI est décrite. L'impact de la structure d'alimentation de l'antenne spirale à double brin sur le coefficient de réflexion et le rapport axial est analysé. Un bon coefficient de réflexion avec une bande passante de 35 GHz à -10 dB et une bonne polarisation circulaire couvrant une intervalle d'angle élévation de 120° indépendamment de l'angle d'azimut sont obtenus. L'efficacité de rayonnement simulée est de 80 % avec un gain simulé de 4.3 dBi....

  3. Communication évaluée dans le service d’assistance téléphonique

    OpenAIRE

    Maj, Magdalena

    2011-01-01

    L’impératif de la communication organisée contraint les organisations de services aux personnes à mettre en place des stratégies de communication cohérentes qui contribuent à créer une image homogène de l’organisation. L’efficacité des pratiques communicatives instaurées par l’organisation est constamment suivie grâce au dispositif d’évaluation très développé. En prenant appui sur l’exemple d’une compagnie aérienne d’origine nord-américaine, cet article analyse les méthodes d’évaluation inter...

  4. Profils de virulence et de résistance aux B-lactamines de souches cliniques de Klebsiellapneumoniae isolées de sondes endotrachéales

    OpenAIRE

    BELAID, KHADIDJA

    2015-01-01

    La présence étude visait à détecter les facteurs de virulence et de résistance aux B-lactamines des souches cliniques de Kiebsiella pneumoniae isolées des prélèvements à partir des sondes d'aspiration trachéale. Au totale, 10 souches de K. pneumoniae ont été isolées, identifiées, et - testés leurs résistances vis-à-vis de 7 antibiotiques (B-Iactamine). Les antibiotiques qui présentent le plus d'efficacité sont: Imipenème et Cefoxitine. La résistance a l'Ampiciline et Ticarcilli...

  5. Le système d’identification automatique (AIS)

    OpenAIRE

    Serry, Arnaud; Lévêque, Laurent

    2015-01-01

    Le système automatique d’identification (AIS) des navires est un outil destiné à accroitre la sécurité de la navigation et l’efficacité de la gestion du trafic maritime. Son utilisation renforce à la fois la sécurité et la sureté maritime. Ses apports sont indéniables malgré quelques carences et limites techniques. Cet article présente les apports et les utilisations de la technologie AIS à l’origine d’une importante manne d’informations riches pour l’étude et la compréhension des circulation...

  6. Suivi des volumes plasmatique, interstitiel et intracelullaire pendant l'hémodialyse par bioimpédance multifréquence et mesure d'hématocrite

    OpenAIRE

    Fenech, Marianne

    2003-01-01

    Le suivi des volumes hydriques du patient hémodialysé permet d'accroître l'efficacité des traitements et d'aider à la détermination du poids sec. Le but de cette thèse est d'améliorer les techniques d'évaluation des volumes hydriques du corps en hémodialyse. Les volumes extra et intracellulaires sont obtenus par bioimpédance, le volume plasmatique par mesures d'hématocrite optique ou ultrasonore. La précision des mesures d'hématocrite par ultrason pu être améliorée grâce à une modélisation pr...

  7. Focus : Un essai de mise en politique de l’eau potable : l’atelier citoyen Dem’eau

    Directory of Open Access Journals (Sweden)

    BARBIER, Rémi ; BEDU, Clémence

    2013-03-01

    Full Text Available L'atelier citoyen Dem'eau, mis en œuvre à Nantes Métropole, avait pour but d'instaurer une interaction entre experts, élus, associations et citoyens les plus divers possibles sur le thème du service public de l'eau. Bien que la plupart de ces groupes aient de nombreux doutes et a priori au sujet de l'efficacité de ce projet, il a permis de mettre en lumière les rapports entre les différents acteurs de la gestion locale et, ainsi, des possibilités d'amélioration de ceux-ci pour l'avenir.

  8. Décentraliser la gestion de réseaux grâce aux agents mobiles

    OpenAIRE

    Galtier, Virginie

    1998-01-01

    Stage de DEA. Rapport de stage.; Dans un contexte où les réseaux informatiques et de télécommunications prennent une importance toujours plus critique, la gestion de réseaux devient une activité cruciale. Mais les systèmes inspirés du modèle centralisé de l'OSI et largement utilisés s'adaptent mal aux nouvelles caractéristiques des réseaux actuels (de plus en plus évolutifs). Utiliser les agents mobiles pour décentraliser cette gestion permettrait de gagner en efficacité en distribuant la tâc...

  9. Contribution à l’amélioration de la lutte contre le paludisme en République Démocratique du Congo (RDC) :Efficacité du traitement préventif intermittent (TPI) de la femme enceinte à la sulfadoxine-pyriméthamine (SP) en contexte d’émergence de la résistance du Plasmodium falciparum, Adhérence des prestataires de soins et des patients à l’association artesunate-amodiaquine (AS-AQ) après changement de la politique nationale de traitement du paludisme simple, Paludisme sévère chez l’enfant à Kisangani (aspects cliniques et évolutifs). / Contribution to the improvement of malaria control in Democratic Republic of Congo (DRC): Effectiveness of intermittent preventive treatment (IPT) for pregnant women with sulfadoxine-pyrimethamine (SP) in the context of emergence of resistance of Plasmodium falciparum, Adherence of healthcare providers and patients to artesunate-amodiaquine (AS-AQ) after the changement of national policy for treatment of uncomplicated malaria, Severe malaria in children in Kisangani (clinical and evolutive aspects).

    OpenAIRE

    Losimba Likwela, Joris

    2012-01-01

    Deuxième pays le plus endémique pour le paludisme au monde, la république démocratique du Congo (RDC) a adopté officiellement l’initiative Faire Reculer le Paludisme en 2001 et depuis, aligne sa politique de lutte contre le paludisme sur les directives de l’OMS dont les orientations les plus récentes consistent en 3 stratégies :[1] assurer aux malades un accès rapide à un traitement efficace et abordable, [2] assurer aux personnes exposées au risque, notamment les jeunes enfants et les femmes...

  10. Inhibition of corrosion of copper in nitric acid solution by some arylmethylene cyanothioacetamide derivatives

    Science.gov (United States)

    Fouda, A. S.; Mohamed, A. K.; Mostafa, H. A.

    1998-01-01

    The inhibition of corrosion of copper in 2M HNO3 solution by some arylmethylene cyanothioacetamide derivatives was tested using polarization measurements. The results showed that these compounds act as mixed type inhibitors and inhibition efficiencies up to 90% can be obtained. The inhibition was assumed to occur via physical adsorption of the inhibitor molecules fitting a Frumkin isotherm. The influence of the substituent group on the inhibition efficiency of the inhibitor was explained in terms of the density of the electron cloud on the cyanothioacetamide moiety and the mode of adsorption. The increase in temperature was found to increase the corrosion in absence and in presence of inhibitors. Some thermodynamic functions were also computed and discussed. L'inhibition de la corrosion du cuivre dans des solutions 2M HNO3 par quelques dérivés d'arylméthylène cyanothioacétamides a été testée par des mesures de polarisation. Les résultats montrent que ces composés se comportent comme des inhibiteurs mixtes. Des efficacités d'inhibition jusqu'à 90 % peuvent être obtenues. L'inhibition est supposée se produire par l'adsorption des molécules d'inhibiteur suivant une isotherme de Frumkin. L'influence de groupe substituant sur l'efficacité de l'inhibiteur a été interprétée en terme de densité du nuage électronique sur la partie cyanothioacétamide et de mode d'adsorption. L'augmentation de la température augmente la corrosion en l'absence et en présence d'inhibiteur. Certaines fonctions thermodynamiques ont également été calculées et discutées.

  11. L’inspection spéciale des impôts et la loi sur la publicité de l’administration

    Directory of Open Access Journals (Sweden)

    Karim Hachimi

    2012-02-01

    Full Text Available L’Inspection Spéciale des Impôts (I.S.I. est l’administration d’élite du Ministère des Finances. Elle considère que la loi du 11 avril 1994 relative à la publicité de l’administration permet aux contribuables malhonnêtes de prendre connaissance du degré d’information de l’I.S.I. quant à leur situation financière. Cette information leur permet de dissimuler au mieux les informations dont l’I.S.I. ne dispose pas encore et qu’elle s’apprêtait à quérir auprès d’eux. Cet état de fait réduit d’autant le redressement fiscal et l’amende qu’ils encourent. Partant du principe que cette loi réduit son efficacité dans la poursuite d’une éventuelle fraude fiscale, l’I.S.I. a décidé de ne pas appliquer la loi. Il n’y a donc plus de garantie juridique pour le contribuable. L’un d’entre eux a porté l’affaire devant le Conseil d’État en juin 1997. L’arrêt rendu fait aujourd’hui encore jurisprudence.Le but de cette petite étude est de décortiquer les arguments de l’I.S.I. et ceux du Conseil d’État pour en retirer une solution permettant à l’I.S.I. de continuer à fonctionner avec autant d’efficacité, tout en respectant la règle de droit.

  12. Quantitative analysis of human herpesvirus-6 genome in blood and bone marrow samples from Tunisian patients with acute leukemia: a follow-up study

    Directory of Open Access Journals (Sweden)

    Faten Nefzi

    2012-11-01

    Full Text Available Abstract Background Infectious etiology in lymphoproliferative diseases has always been suspected. The pathogenic roles of human herpesvirus-6 (HHV-6 in acute leukemia have been of great interest. Discordant results to establish a link between HHV-6 activation and the genesis of acute leukemia have been observed. The objective of this study was to evaluate a possible association between HHV-6 infection and acute leukemia in children and adults, with a longitudinal follow-up at diagnosis, aplasia, remission and relapse. Methods HHV-6 load was quantified by a quantitative real-time PCR in the blood and bone marrow samples from 37 children and 36 adults with acute leukemia: 33 B acute lymphoblastic leukemia (B-ALL, 6 T acute lymphoblastic leukemia (T-ALL, 34 acute myeloid leukemia (AML. Results HHV-6 was detected in 15%, 8%, 30% and 28% of the blood samples at diagnosis, aplasia, remission and relapse, respectively. The median viral loads were 138, 244, 112 and 78 copies/million cells at diagnosis, aplasia, remission and relapse, respectively. In the bone marrow samples, HHV-6 was detected in 5%, 20% and 23% of the samples at diagnosis, remission and relapse, respectively. The median viral loads were 34, 109 and 32 copies/million cells at diagnosis, remission and relapse, respectively. According to the type of leukemia at diagnosis, HHV-6 was detected in 19% of the blood samples and in 7% of the bone marrow samples (with median viral loads at 206 and 79 copies/million cells, respectively from patients with B-ALL. For patients with AML, HHV-6 was present in 8% of the blood samples and in 4% of the bone marrow samples (with median viral loads at 68 and 12 copies/million cells, respectively. HHV-6 was more prevalent in the blood samples from children than from adults (25% and 9%, respectively and for the bone marrow (11% and 0%, respectively. All typable HHV-6 were HHV-6B species. No link was shown between neither the clinical symptoms nor the

  13. Possible complications of erythropoietin therapy in patients with chronic renal failure

    Directory of Open Access Journals (Sweden)

    Plješa Steva J.

    2004-01-01

    Full Text Available Introduction There have been many publications in the past 20 years about positive effects of human recombinant erythropoietin, which is used in treatment of anemia, especially in patients on dialysis. Complications The most important complications in patients treated with erythropoietin include: hypertensive reactions; thrombosis of AV fistula in patients on hemodialysis and appearance of severe anemia as a part of Pure Red Cell Aplasia (PRCA. The first two complications were managed quite easily with adequate erythropoietin dosage, and slower establishment of normal hemoglobin kevel, hematocrit level and red blood cell count, (our "target" Hb varied between 100 and 110 g/dl. Pure Red Cell Aplasia (PRCA Pure Red Cell Aplasia is a progressive, marked anemia with sudden appearance of signifacnt loss or complete absence of erythrocyte precursor cells in normal bone marrow. In patients with end stage renal disease treated with erythropoietin PRCA appears in acute form as a consequence of production of neutralizing antibodies to erythropoietin. Time period between the beginning of erythropoietin therapy and appearance of PRCA is from 3 weeks to approximately 9 months. Symptoms and signs PRCA is characterized by sudden appearance of anemia in patients who had a satisfactory response to erythropoietin therapy till that moment. In PRCA, anemia is normocytic, normochromic with normal survival of red blood cells, without deficit in components such as iron, folic acid or vitamin B12, low reticulocyte count, decrease in Hg and normal platelet count. Diagnosis Diagnosis is based on clinical data (marked anemia, bone marrow biopsy, which shows a lower number of precursor red blood cells and presence of antibodies against erythropoietin. Before PRCA is diagnosed, all other causes for erythropoietin resistance must be excluded. Therapy Therapy of PRCA is based on cessation of erythropoietin therapy (all kinds, and correction of anemia with blood transfusions

  14. Severe lymphedema caused by repeated self-injury.

    Science.gov (United States)

    Mihara, M; Hara, H; Murai, N; Todokoro, T; Iida, T; Narushima, M; Koshima, I

    2011-12-01

    Lymphedema is divided into primary and secondary forms. Primary lymphedema often develops in young people and may be caused by lymphvascular aplasia, hypoplasia, and hyperplasia. The most frequent cause of secondary lymphedema after lymphatic filariasis is regional lymph node dissection for treatment of a malignant tumor, and this complication occurs most frequently in middle aged or older patients. Here, we describe a relatively young patient (27 years old) in whom collecting lymph vessels in the upper limb were disrupted by repeated self-injury, with resultant lymphedema. There have been very few reports on lymphedema caused by self-induced trauma. This case report illustrates that secondary lymphedema should also be considered and evaluated appropriately when diagnosed in a relatively young patient without a history of cancer or infection. PMID:22458120

  15. Prenatal diagnosis of proximal focal femoral deficiency: Literature review of prenatal sonographic findings.

    Science.gov (United States)

    D'Ambrosio, Valentina; Pasquali, Gaia; Squarcella, Antonia; Marcoccia, Eleonora; Filippis, Angela De; Gatto, Silvia; Camilla, Aliberti; Pizzuti, Antonio; Torre, Renato La; Giancotti, Antonella

    2016-05-01

    Proximal focal femoral deficiency (PFFD) is a rare musculoskeletal malformation that occurs in 0.11-0.2 per 10,000 live births. This congenital anomaly involves the pelvis and proximal femur with widely variable manifestations, from mild femoral shortening and hypoplasia to the absence of any functional femur and acetabular aplasia. Prenatal diagnosis of PFFD is still a challenge, but early recognition of this malformation could provide useful information to both parents and physicians concerning management and therapeutic planning. For this review, we analyzed all the cases of prenatally diagnosed PFFD that were reported in the literature from 1990 to 2014 and provide a description of the most common prenatal sonographic findings. © 2015 Wiley Periodicals, Inc. J Clin Ultrasound 44:252-259, 2016. PMID:26408260

  16. Invasive pulmonary aspergillosis in acute leukemia: Contribution of CT to early diagnosis and aggressive management

    International Nuclear Information System (INIS)

    More than 80% of patients with invasive pulmonary aspergillosis (IPA) who received antileukemic chemotherapy survived the infection as a result of early diagnosis and aggressive therapy. CT helped to establish the early diagnosis of IPA in these patients. Since first describing the CT findings of IPA, the authors have added ten new cases, each subsequently confirmed. The CT ''halo sign,'' a zone of lower attenuation surrounding a pulmonary mass, was seen in eight of nine patients on early scans obtained during aplasia. A characteristic progression from multiple fluffy masses to cavitation suggested IPA in five of seven patients. CT findings affected patient management in seven of ten patients and were one criterion for increasing antifungal therapy. The CT appearance of healing IPA resembled that of resolving pulmonary infarcts, and was used to monitor disease activity in the long term

  17. Autoimmune Cytopenias in Chronic Lymphocytic Leukemia

    Directory of Open Access Journals (Sweden)

    Giovanni D'Arena

    2013-01-01

    Full Text Available The clinical course of chronic lymphocytic leukemia (CLL may be complicated at any time by autoimmune phenomena.The most common ones are hematologic disorders, such as autoimmune hemolytic anemia (AIHA and immune thrombocytopenia (ITP. Pure red cell aplasia (PRCA and autoimmune agranulocytosis (AG are, indeed, more rarely seen. However, they are probably underestimated due to the possible misleading presence of cytopenias secondary to leukemic bone marrow involvement or to chemotherapy cytotoxicity. The source of autoantibodies is still uncertain, despite the most convincing data are in favor of the involvement of resting normal B-cells. In general, excluding the specific treatment of underlying CLL, the managementof these complications is not different from that of idiopathic autoimmune cytopenias or of those associated to other causes. Among different therapeutic approaches, monoclonal antibody rituximab, given alone or in combination, has shown to be very effective.

  18. Você conhece esta síndrome? Do you know this syndrome?

    Directory of Open Access Journals (Sweden)

    Nadia Aparecida Pereira de Almeida

    2010-02-01

    Full Text Available A síndrome de Bart é caracterizada pela tríade de manifestações clínicas: epidermólise bolhosa, aplasia de cútis e anormalidades ungueais. Presume-se que a ausência congênita de pele segue as linhas de Blaschko. O tratamento visa a evitar infecções secundárias. O prognóstico é bom e depende da cicatrização das bolhas.Bart's syndrome is characterized by three clinical manifestations: epidermolysis bullosa, congenital absence of skin, and nail abnormalities. It is believed that congenital skin absence follows the patterns of Blaschko's lines. Treatment seeks to prevent secondary infection. Prognosis is favorable and depends upon the healing of lesions.

  19. Proboscis lateralis of nose-a case report.

    Science.gov (United States)

    Magadum, Sunil Bajarang; Khairnar, Prashant; Hirugade, Shivprasad; Kassa, Vijay

    2012-04-01

    Lateral proboscis is a rare craniofacial malformation characterized by a rudimentary tubular, nose-like structure located off-center from the vertical midline of the face, and occur in association with a wide spectrum of other anomalies, including heminasal aplasia spectrum,mental retardation, callosal agenesis, heminasal hypoplasia, microphthalmia, and atypical clefting syndrome. Evaluation of a patient should include CT scan examination to look for growth of facial and skull bones. Reconstruction should start at an early age. Proboscis itself is the best option for heminose formation. Cartilaginous or bony support can be planned later in the late teens. Esthetic and psychological problems are often concern of the patient and families. Here we presented a male infant of 2 months with Proboscis Lateralis. There was no e/o cleft lip or cleft palate. Staged repair was done at an early age to avoid anxiety of parents and to allow proportionate growth of nose and face. PMID:23543614

  20. Unusual association between cardiac, skeletal, urogenital and renal abnormalities.

    Science.gov (United States)

    Goryaeva, Maria; Sykes, Mark Christopher; Lau, Benjamin; West, Simon

    2016-01-01

    We present a 33-year-old woman with an array of congenital abnormalities. She has been diagnosed with polycystic kidney disease (PCKD) with no detectable mutations in PKD1 or PKD2, spina bifida occulta, thoracic skeletal abnormalities, a uterus didelphys and a patent foramen ovale (PFO). There are several associations reported in the literature that include abnormalities similar to the patient's, but none describe her presentation in its entirety. The MURCS association is characterised by (MU)llerian duct aplasia, (R)enal dysplasia and (C)ervical (S)omite anomalies and goes some way in explaining these condition. Patients with both MURCS and PCKD have not been described in current literature. Through this report, we hope to bring a potential diagnosis to light and provide the patient with an improved understanding of her health. PMID:27402585

  1. Linking Drugs to Obscure Illnesses

    DEFF Research Database (Denmark)

    Bennett, Charles L; Starko, Karen M; Thomsen, Henrik S;

    2012-01-01

    Identification of serious adverse drug reactions (sADRS) associated with commonly used drugs can elude detection for years. Reye's syndrome (RS), nephrogenic systemic fibrosis (NSF), and pure red cell aplasia (PRCA) among chronic kidney disease (CKD) patients were recognized in 1951, 2000, and 1998......, in 1996, the Danish Medicine Agency approved high-dose gadodiamide administration to chronic kidney disease (CKD) patients undergoing MR scans. Overall, 88 % of Danish NSF cases were from two hospitals and 97 % of United States' NSF cases were from 60 hospitals. These hospitals frequently administered......-savings considerations, and a European regulatory requirement requiring removal of albumin as a stabilizer, led to toxicity. Overall, 81, 13, and 17 years elapsed between drug introduction into practice and identification of a causal relationship for aspirin, erythropoietin, and gadodiamide, respectively. A substantial...

  2. Spectrum of bronchopulmonary anomalies associated with tracheoesophageal malformations

    Energy Technology Data Exchange (ETDEWEB)

    Benson, J.E.; Fletcher, B.D.; Olsen, M.

    1985-09-01

    The combination of tracheoesophageal and pulmonary malformations is unusual and reportedly carries a high mortality. We have observed six patients with esophageal atresia and tracheoesophageal fistula and one with a bronchoesophageal fistula who had associated bronchopulmonary anomalies ranging from lobar hypoplasia and agenesis to unilateral pulmonary hypoplasia or agenesis. All of the pulmonary malformations were right-sided. Vertebral or rib anomalies were present in five patients, congenital heart disease in two, imperforate anus in one and one patient had radial aplasia and Pierre Robin syndrome. The bronchopulmonary anomalies complicated the surgical care of tracheoesophageal malformations and required radiologic differentiation from aspiration pneumonia and atelectasis. Six of the seven patients survived. Mortality and morbidity were related to complications and associated cardiac anomalies as well as severity of the lung anomaly.

  3. Medical program in radiation protection from the Argentine Nuclear Regulatory Authority

    International Nuclear Information System (INIS)

    This program is carried out by the Radio pathology Laboratory, belonging to the Nuclear Regulatory Authority. The program includes the following aspects: 1) planning and organization of medical response in radiological emergencies. A three-level system of medical assistance has been developed considering: a- determination of each level of care and their potential roles; b- choice of medical facilities for medical assistance; c- preparedness for medical response (equipment s, logistic support, human resources, training). 2) scientific research activities related to radio pathology subjects: a- hematological indicators in radioinduced aplasia; b- biological and biophysical dosimeters; c- radiation effects on the developing brain. 3) edition of practical guidelines for diagnostic and treatment: a- external and internal radioactive contamination; b- acute radiation syndrome; c- radiological burns. 4) medical advising in radioprotection (risk assessment in radiation workers, medical exposures, potential effects of prenatal irradiation). 5) international interactions: activities related with the constitution of a Latin American radio pathology network, linkage with international reference centers. (author)

  4. Congenital absence of uterine cervix

    Directory of Open Access Journals (Sweden)

    Selvaraj Ravi Lakshmy

    2016-10-01

    Full Text Available Cervical agenesis or dysgenesis is an extremely rare congenital anomaly. Patients with congenital absence of the cervix present with primary amenorrhea and infertility. Though it poses a diagnostic challenge to the clinician, correct diagnosis prior to surgery is possible with the help of ultrasound. Early diagnosis offers significant advantages in patient care and effective presurgical planning. This case report reviews two cases of cervical agenesis diagnosed with the help of ultrasound and later confirmed with the help of MRI. Ultrasonography is the modality of choice to define the internal genital anatomy and helps us to classify the level of obstruction or aplasia in obstructive uterine anomalies. [Int J Reprod Contracept Obstet Gynecol 2016; 5(10.000: 3634-3636

  5. Use of radiotherapy for consolidation of remission in lymphogranulomatosis of the stages IIIB-IV

    International Nuclear Information System (INIS)

    Three different patterns of combined therapy of 81 patients in stages IIIB-IV of lymphogranulomatosis were comparatively analyzed. The irradiation of all earlier affected regions and of the adjacent lymph vessels with a total tumor dose of 20 - 25 Gy following a 6-series polychemotherapy with incomplete lymph node regression the dose was increased to 40 Gy proved to be most effective. In cases of smaller tumor spread, when all the affected areas could be simultaneously irradiated, radiotherapy was successfully performed after 3 series of chemotherapy. The irradiation of all affected lymph vessels with 40 Gy total tumor dose is not useful as it leads to a constant bone marrow aplasia in the exposed bones which hinders the effective treatment of later recidivations

  6. Oral and Dental Manifestations of Diamond-Blackfan Anemia: Case Reports

    Science.gov (United States)

    Ozden, Feyza Otan; Gunduz, Kaan; Ozden, Bora; Isci, K. Devrim; Fisgin, Tunc

    2011-01-01

    Diamond-Blackfan Anemia (DBA) is a red cell aplasia characterized with physical abnormalities. The incidence of the disease is reported to be five to seven (5–7) cases per million births in Europe and 4–5 per million live births in the UK and Netherlands with equal sex ratio. It was first recognized in 1938 but an exact pathophysiology of the disease has not been described yet. These abnormalities are well known, however, detailed oral and dental conditions related with the disease have not been described previously. We herein presented two cases of DBA together with oral and dental findings. Our study is first to report the gingival status of the patients with a complete investigation of any orthodontic or dental abnormalities in these kind of patients. A careful follow up and preventive therapies should not be missed in these kind of patients. PMID:21769279

  7. Hypoplasia of exocrine pancreas with myocardial necrosis

    Institute of Scientific and Technical Information of China (English)

    Xiang Sheng Zhang; Xin Xiu Xu; Yan Zhang; Sbu Hua Wu

    2000-01-01

    AIM To study the clinical and pathological features of hypoplasia of exocrine pancreas with myocardialnecrosis.METHODS One ease of hypoplasia of exocrine pancreas with myocardial necrosis was autopsied. Theclinical signs and pathological changes were analyzed.RESULTS A 15-month-old boy with hypoplasia of exocrine pancreas was reported. The main clinicalfeatures were steatorrhea and marked underdevelopment. He died of acute heart failure afterhospitalization. Autopsy showed that there were aplasia of exocrine portion and fatty metaplasia ofpancreas, the myocardium revealed focal necrosis and sear formation.CONCLUSION Atrophy of exocrine pancreas and myocardial necrosis exist at the same time, suggestingthat there may be some relationship between them. It was likely that the damaged pancreatic tissue releasedsome active materials that may harm the myocardium or decrease pancreatic juice that results in lack ofnutrient and myocardial necrosis.

  8. Basic conditions for radioimmunoassay of erythropoietin, and plasma levels of erythropoietin in normal subjects and anemic patients

    Energy Technology Data Exchange (ETDEWEB)

    Mizoguchi, Hideaki; Ohta, Kazuo; Suzuki, Toshiaki; Murakami, Akihiko; Ueda, Masatsugu; Sasaki, Ryuzou; Chiba, Hideo

    1987-02-01

    We have developed a specific and sensitive radioimmunoassay for erythropoietin. The sensitivity of our assay is 0.5 mU or 5 mU/ml and is sufficient to detect normal plasma erythropoietin levels. The mean plasma erythropoietin titer of normal Japanese with our radioimmunoassay was found to be 21.9 +- 12.0 mU/ml (n = 199). The validity of the method was further confirmed by the observations that the plasma erythropoietin titers were inversely related to hemoglobin levels in patients with nonuremic anemias, lower in uremic patients than in patients with nonuremic anemias with similar hemoglobin levels, markedly elevated in patients with aplastic anemia and pure red cell aplasia, and in a low normal range in patients with polycythemia vera.

  9. Hematologycal disorders in mice of C57BL family exposed to full body radiation by Radioactive Cobalt

    International Nuclear Information System (INIS)

    Seven groups of 5C57B1 mice were submitted to full body radiation ina a single dose of 1.000 r (258m C/Kg). Each group was sacrified respectively on the 5th, 7th, 8th, and 10th day after exposition to radiation. Another group (8th) of 5 animals was used as control group, and was to submitted to radiation. Before sacrificing the animals, peripheral blood was collected to prepare extensions which were stained by Leishman. Then the left femur was removed in order to prepare sections of the bone marrow. We observed accentuated reduction of blood corpuscles, parallel to a similar medullar depression that occurred progressively until the 10th day, when aplasia was almost total. At that time the bone marrow showed almost exclusively lymphocytes, plasmocytes, fibroblasts and endothelial cells, with arare megacaryocytes. However, blood platelets remained normal in the peripheral blood. (author)

  10. Trisomy 8p (p11.2-pter due to maternal translocation t(8;13(p11;p12 in a child with dysmorphic features

    Directory of Open Access Journals (Sweden)

    Mahjoubi F

    2005-01-01

    Full Text Available Here we present a phenotypic description of a male child with trisomy 8p resulting from a maternal balanced reciprocal translocation. The patient presented with dysmorphic face, aplasia of the corpus callosum, and atrophy of cortex, congenital heart defect and marked hypotonia. The father had a normal karyotype. The mother had an apparently balanced translocation involving chromosomes 8 and 13 [46, XX, t(8;13(p11.2;p12]. The karyotype of the child was ascertained as 46, XY, der(13t(8;13(p11.2;p12. This is the second reported case of trisomy 8p resulting from a translocation between chromosomes 8 and 13. The chromosomal breakpoints in the two cases differed.

  11. Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors.

    Science.gov (United States)

    Yılmaz Karapınar, Deniz; Karadaş, Nihal; Önder Siviş, Zühal; Balkan, Can; Kavaklı, Kaan; Aydınok, Yeşim

    2015-09-01

    Experiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML), one with FMS-like tyrosine kinase-3-internal tandem duplication mutation and the other with a single base mutation (D835Y). Both patients received sorafenib, one for 19 days and the other for 42 days, with clofarabine-including chemotherapy. One additionally received sunitinib for a total of 20 days. Both patients developed severe pancytopenia, hypertension, life-threatening bleedings from the gastrointestinal system, and, finally, intrapulmonary hemorrhage. Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis. PMID:25912283

  12. Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors

    Directory of Open Access Journals (Sweden)

    Deniz Yılmaz Karapınar

    2015-09-01

    Full Text Available Experiences with new multikinase inhibitors are limited, especially in children. In this report we summarize our experience with 2 patients with relapsed acute myeloblastic leukemia (AML, one with FMS-like tyrosine kinase-3-internal tandem duplication mutation and the other with a single base mutation (D835Y. Both patients received sorafenib, one for 19 days and the other for 42 days, with clofarabine-including chemotherapy. One additionally received sunitinib for a total of 20 days. Both patients developed severe pancytopenia, hypertension, life-threatening bleedings from the gastrointestinal system, and, finally, intrapulmonary hemorrhage. Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis.

  13. [Hemoglobin C (alpha 2 beta 2 6Glu-->lys). Study of 19 heterozygote AC carriers and of 5 cases of double hemoglobinopathy SC].

    Science.gov (United States)

    De Caluwé, J P; Alexander, M; Bondue, H

    1993-01-01

    This paper describes clinical findings in subjects heterozygous for hemoglobin C and in compound heterozygotes SC. Most of our patients were coming from lands bordering the Guinea Gulf, on the inside of the loop made by the river Niger and from Haiti, which was populated by African slaves coming mainly from the Golden Coast (actually Ghana). Heterozygotes are asymptomatic and do not suffer from anemia. Age at diagnosis is higher than for SCA, although one of our cases was diagnosed at age one. Overwhelming infections or major anemia were not observed. Basal hemolysis remained moderate. HbF levels were not increased as they may be in sickle cell anemia. Splenomegaly was observed in 2/5 patients. Among severe complications we encountered, we must mention one case of foetal death, one tibial infarct, one case of pure red cell aplasia caused by parvovirus B19 infection, and one case of proliferative retinopathy. PMID:8291338

  14. Drug-Induced Hematologic Syndromes

    Directory of Open Access Journals (Sweden)

    David M. Mintzer

    2009-01-01

    Full Text Available Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and reviews focus on individual drugs or cytopenias. Results. Drug-induced syndromes include hemolytic anemias, methemoglobinemia, red cell aplasia, sideroblastic anemia, megaloblastic anemia, polycythemia, aplastic anemia, leukocytosis, neutropenia, eosinophilia, immune thrombocytopenia, microangiopathic syndromes, hypercoagulability, hypoprothrombinemia, circulating anticoagulants, myelodysplasia, and acute leukemia. Some of the classic drugs known to cause hematologic abnormalities have been replaced by newer drugs, including biologics, accompanied by their own syndromes and unintended side effects. Conclusions. Drugs can induce toxicities spanning many hematologic syndromes, mediated by a variety of mechanisms. Physicians need to be alert to the potential for iatrogenic drug-induced hematologic complications.

  15. Expanding the phenotypic spectrum of PORCN variants in two males with syndromic microphthalmia.

    Science.gov (United States)

    Brady, Paul D; Van Esch, Hilde; Fieremans, Nathalie; Froyen, Guy; Slavotinek, Anne; Deprest, Jan; Devriendt, Koenraad; Vermeesch, Joris R

    2015-04-01

    Variants in PORCN are a cause of Goltz-Gorlin syndrome or Focal Dermal Hypoplasia, an X-linked dominant disorder affecting heterozygous females and until now considered to be embryonic lethal in males. Exome sequencing was performed in a family in which two male siblings were characterized by microphthalmia and additional congenital anomalies including diaphragmatic hernia, spina bifida and cardiac defects. Surprisingly, we identified a maternally inherited variant in PORCN present in both males as well as in two female siblings. This represents the first finding of a PORCN variant in non-mosaic males affected with Goltz-Gorlin syndrome. The apparently asymptomatic mother showed extreme skewing of X-inactivation (90%), an asymptomatic female sibling showed skewing of 88%, and the second female sibling affected with cutis aplasia of the scalp showed X-inactivation considered within the normal range.

  16. Erupted compound odontome

    Directory of Open Access Journals (Sweden)

    Shekar S

    2009-01-01

    Full Text Available Odontomas are considered to be hamartomas rather than a true neoplasm. They consist chiefly of enamel and dentin, with variable amount of pulp and cementum when fully developed. They are generally asymptomatic and are included under the benign calcified odontogenic tumors. They are usually discovered on routine radiographic examination. Eruption of an odontoma in the oral cavity is rare. Peripheral compound odontomas arise extraosseously and have a tendency to exfoliate. In this article we are reporting a case of a 15-year-old girl with peripheral compound odontoma, with a single rudimentary tooth-like structure in the mandibular right second molar region, which is about to be exfoliated. Its eruption in the oral cavity and location in the mandibular posterior region is associated with aplasia of the mandibular right second molar, making it an interesting case for reporting.

  17. Imaging diagnosis of thyroid gland congenital anomalies

    International Nuclear Information System (INIS)

    The clinical and radiological findings in 25 patients presenting diverse thyroid gland anomalies are described, as follows: thyroid aplasia - 2, thyroid hemiagenesis - 9, lingual thyroid gland - 3, median cervical cysts - 8, lateral cervical aberrant tissue - 2, distant aberrant thyroid tissue - 1 case. In all patients the following methods are applied: echography, computer tomography and radionuclide examination with 99mTc. Conclusions are made that: 1) To make definite diagnosis of thyroid ectopia the complex application of imaging methods is mandatory. 2) Ultrasound examination is sufficient to establish agenesis, hypo- or hemiaplasia of the thyroidea without need to resort to other imaging modalities. 3) Ectopic thyroid tissue eventually discovered should be carefully monitored by echography and cytologically because of susceptibility of malignant degeneration

  18. Walker-Warburg syndrome: report of two cases

    Directory of Open Access Journals (Sweden)

    VASCONCELOS MARCIO M.

    1999-01-01

    Full Text Available The purpose of this study is to describe two infants that were diagnosed with Walker-Warburg syndrome (WWS, a rare form of congenital muscular dystrophy (CMD.They were studied in their clinical, laboratory, and neuroradiologic features. The index case had a brain magnetic resonance imaging (MRI and the second patient had a head computerized tomography (CT. In addition, a literature review was performed to describe the main forms of CMD. The index case fulfilled all criteria for WWS. A brain MRI performed at age 4 months served to corroborate the clinical diagnosis, showing severe hydrocephalus, type II lissencephaly, cerebellar vermian aplasia, and a hypoplastic brain stem. The authors were able to establish a retrospective diagnosis of WWS in the index case's older sister, based upon her clinical picture and head CT report.

  19. Magnetic Resonance Imaging Findings in Small Patella Syndrome.

    Science.gov (United States)

    Kim, Hyoung-Soo; Yoo, Jeong-Hyun; Park, Noh-Hyuck; Chang, Jun-Hee; Ban, Yun-Seong; Song, Sang-Heon

    2016-03-01

    Small patella syndrome (SPS) is characterized by aplasia or hypoplasia of the patella and pelvic girdle abnormalities, including bilateral absence or delayed ossification of the ischiopubic junction and infra-acetabular axe-cut notches. Here, we report a case of SPS in a 26-year-old female. Magnetic resonance image (MRI) showed a small patella with thick eccentric non-ossified patellar cartilage and femoral trochlear dysplasia with hypoplastic patellar undersurface. To our knowledge, this is the first report of MRI findings in SPS. MRI findings could be clinically relevant because elongation of the medial patellofemoral ligament and trochlear dysplasia with eccentric non-ossified patellar cartilage might lead to patellofemoral maltracking with an osteochondral lesion or acute dislocation or an extensor mechanism injury. Though the patient presented in this case report only had a gastrocnemius injury at the origin site, physicians should carefully examine abnormalities with MRI when an SPS patient has a trauma to the knee. PMID:26955616

  20. Evaluation of delayed effects of ionizing radiation: an historical perspective.

    Science.gov (United States)

    Stewart, A M

    1991-01-01

    It is widely assumed that after the bombing of Hiroshima and Nagasaki there were no lasting effects of the acute injuries (which included extensive damage to blood forming tissues by the radiation) or the massively high death rate (which was caused by environmental effects of the blast as well as personal injuries). However, close inspection of the dose response curves for non-cancer deaths has shown that this could be a false impression caused by one effect of marrow aplasia being confused with leukemia (defective erythropoiesis) and a second effect being confused with early selection in favor of general fitness (defective immune responses). Possible consequences of such confusion (for cancer risk coefficients) are discussed in relation to what is known about late effects of prenatal x-rays and occupational exposures to radiation. PMID:1805618