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Sample records for aplasia efficacite therapeutique

  1. Vermian aplasia and hypoplasia

    International Nuclear Information System (INIS)

    This paper reports vermian aplasia or hypoplasia unrelated to Dandy-Walker complex or Joubert syndrome. Vermian hypoplasia is most commonly associated with the malformations of Dandy-Walker cyst or variant. There have been few reports of familial vermian anomaly (Joubert syndrome) with episodes of polypnea and apnea. Five patients with vermian hypoplasia or absence were prospectively discovered among 1,130 children undergoing brain MR imaging. Ages ranged from 2 mo to 15 y at the time of discovery: The abnormalities were poorly defined in three patients who had previously undergone CT. There was no common link in these patients with a variable number of other systemic, brain, or facial abnormalities. No unifying symptoms were identified. Two patients had the MR imaging appearance of Joubert syndrome, but none had the cyclical respiratory symptoms usually associated with this syndrome

  2. Radiological Findings of Michel Aplasia

    Science.gov (United States)

    Umul, Ayse; Demirtas, Hakan; Celik, Ahmet Orhan

    2016-01-01

    Introduction: Congenital abnormalities of the inner ear is the most common cause of neurosensory hearing loss. Michel inner ear deformity is a rare developmental anomaly refers to the total aplasia of the inner ear. It is caused by developmental arrest of otic placode early during the third week of gestational age. Case report: We have discussed here that three year old girl diagnosed Michel aplasia with temporal bone computed tomography (CT) and temporal magnetic resonance imaging (MRI) findings. PMID:27482139

  3. Pure red cell aplasia and associated thymoma

    Directory of Open Access Journals (Sweden)

    Cristian Rosu

    2011-04-01

    Full Text Available Pure red cell aplasia is a rare cause of anemia, caused by an absence of red blood cell precursors in the bone marrow. It is usually a paraneoplastic syndrome, associated most commonly with large-cell granular lymphocyte leukemia but also thymoma. For patients who present both pure red cell aplasia and thymoma, thymectomy leads to an initial remission of the aplasia in 30% of cases. However, sustained remission may require the addition of medications such as corticosteroids, cyclospo­rine, or cyclophosphamide. We present a case of pure red cell aplasia associated with a thymoma in an otherwise healthy 80 year-old woman.

  4. Genetics Home Reference: nonsyndromic aplasia cutis congenita

    Science.gov (United States)

    ... round or oval, others rectangular, and still others star-shaped. They usually leave a scar after they ... pregnant mother can cause the baby to be born with the skin lesions characteristic of nonsyndromic aplasia ...

  5. Aplasia of major pectoral muscle combined with renal aplasia and cystic malformation of common iliac vein

    DEFF Research Database (Denmark)

    Qvist, N; Nielsen, K; Christensen, P V

    1987-01-01

    We report a case of an eighteen-year-old male with combined aplasia of the major pectoral muscle, renal aplasia, and malformation of the common iliac vein. The possibility of a common genesis is discussed on the basis of embryology....

  6. Ectrodactyly with fibular aplasia : A separate entity?

    NARCIS (Netherlands)

    Menke, Leonie A.; Bijlsma, Emilia K.; van Essen, Anthonie J.; van den Boogaard, Marie-Jose H.; van Rijn, Rick R.; Cobben, Jan Maarten

    2008-01-01

    E/FA is the combination of ectrodactyly (split hand/foot malformation, SHFM) and fibular aplasia. It is a rare disorder considered to be inherited in an autosomal dominant fashion with reduced penetrance and variable expression. In order to determine recurrence risks for the two patients we describe

  7. Aplasia Cutis Congenita: a Case Report

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    Tahereh Esmaeilnia Shirvany

    2009-06-01

    Full Text Available Background:Aplasia cutis congenital (ACC is a congenital absence of skin most commonly affecting the scalp. No definite etiology is available but multiple causes such as intrauterine infection, fetal exposure to cocaine, heroin, alcohol or antithyroid drugs, vascular disruption, genetic causes, syndromes and teratogens have been suggested. Case Presentation: We present an infant with symmetrical type of aplasia cutis on the trunk and proximal limbs. She was product of triple pregnancy with two fetuses papyraceous at 12th week of gestational age and at birth. She is treated by non surgical management despite remarkable extent of the lesion.Conclusion:ACC of the trunk is less common than of scalp. Lesion often is symmetric and seen after fetus papyraceous in multiple pregnancies.

  8. Pure white cell aplasia in a dog.

    Science.gov (United States)

    Weiss, Douglas J; Henson, Michael

    2007-12-01

    A 3-year-old Irish Wolfhound was evaluated because of acute onset of lethargy and fever. Severe neutropenia (0/microL; reference interval 2500-11,200/microL) was associated with granulocyte aplasia in the bone marrow (myeloid:erythroid ratio, 0.009:1). Antineutrophil antibodies were assessed by an indirect immunofluorescence assay using flow cytometry. When normal canine leukocytes were incubated with the patient's serum and anti-IgG, a marked shift was observed in the forward-angle light scatter of the neutrophil population, and the monocyte cluster disappeared, possibly the result of fragmentation or lysis. Both neutrophil fluorescence intensity (309 +/- 11 median channel units [MCU], control values 107-152 MCU) and the percentage of neutrophils with increased fluorescence intensity (61 +/- 5%, control values 3.8-13.7%) were increased in the patient's serum, consistent with the presence of antineutrophil antibodies. Repeated episodes of neutropenia occurred while treatment with steroidal and nonsteroidal immunosuppressive therapy was initiated and modified. The neutrophil count eventually stabilized in the low-normal range, and the dog was maintained for the next 15 months on prednisone (0.4 mg/kg PO q 48 h) and azathioprine (2 mg/kg daily). During this period, the dog developed immune-mediated hemolytic anemia and thrombocytopenia, decubital ulcers, nasal aspergillosis, and eventually, multi-organ septicemia, which led to euthanasia on day 784. A diagnosis of pure white cell aplasia was made in this dog, based on the many similarities to human patients with pure white cell aplasia, including severe neutropenia with selective granulocyte aplasia, serum antineutrophil antibodies, remission dependent on treatment with immunosuppressive therapy, and recurrent bacterial infections. PMID:18041706

  9. Pulmonary Aplasia in an Adult : A Case Report

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    Nurettin Yiyit

    2016-01-01

    Full Text Available Pulmonary aplasia is a rare congenital anomaly in which there are absence of pulmonary vessels, bronchus and parenchyma. It is distinguished from pulmonary agenesis by the presence of rudimentary stump bronchus. Patients are usually diagnosed in childhood. Patients without additional anomaly and the patients with mild disease can be diagnosed in adulthood. The left lung was not observed at the chest X-ray of 19-year-old male patient with respiratory distress in exercise. Left lung aplasia was diagnosed by computed tomography and ventilation perfusion scintigraphy. The patients with lung aplasia have an increased risk of infections. Therefore the follow-up of the patients is important.

  10. A. Bandura. Auto-efficacité. Le sentiment d’efficacité personnelle

    OpenAIRE

    Rondier, Maïlys

    2009-01-01

    Albert Bandura est docteur en psychologie et enseigne à l’université de Stanford (Californie). Il est l’auteur de L’Apprentissage social (Mardaga, 1985). Depuis les années 80, Albert Bandura s’intéresse au sentiment d’efficacité personnelle. Ce concept s’inscrit dans le cadre de la théorie sociocognitive (théorie issue du béhaviorisme et du cognitivisme). Selon cette théorie, le fonctionnement et le développement psychologique doivent être compris en considérant trois facteurs en interaction ...

  11. Genetics Home Reference: Müllerian aplasia and hyperandrogenism

    Science.gov (United States)

    Skip to main content Your Guide to Understanding Genetic Conditions Enable Javascript for addthis links to activate. ... Conditions Genes Chromosomes & mtDNA Resources Help Me Understand Genetics Home Health Conditions Müllerian aplasia and hyperandrogenism Müllerian ...

  12. Laparoscopic Morcellation of Didelphic Uterus With Cervical and Renal Aplasia

    OpenAIRE

    Altchek, Albert; Brodman, Michael; Schlosshauer, Peter; Deligdisch, Liane

    2009-01-01

    This is a case report (and review of the literature) of a 12-year and 10-month-old girl with a rare congenital anomaly of uterus didelphys, unilateral cervix aplasia, and ipsilateral renal aplasia. She had severe dysmenorrhea from the first menses. In an effort to preserve fertility, a cervical fistula was made that closed over. A laparoscopic hemi-hysterectomy was done successfully and rapidly with laparoscopic morcellation. Because no ureter was present, it was not necessary to trace it. Fo...

  13. CT complete congenital eventration of diaphragm with aplasia of lung

    International Nuclear Information System (INIS)

    Diaphragmatic anomalies are commonly associated with unilateral pulmonary hypoplasias. However complete eventration of the diaphragm with aplasia of the ipsilateral lung is a rare combination of congenital anomalies. The clinical profile and computed tomography (CT) findings in a new-born with complete eventration of right hemidiaphragm and aplasia of right lung are presented. It is thus demonstrated that CT is a very effective, non invasive means of diagnosis which in the past depended largely on invasive procedures such as bronchography, angiography and thoracotomy. 16 refs., 3 figs

  14. Aplasia cutis congenita of the scalp: Therapeutic modalities

    OpenAIRE

    Shivakumar S; Dwarakanath S; Swaroop Gopal; Venkataramana N

    2006-01-01

    Agenesis of scalp is an uncommon but well-recognized clinical entity. Congenital scalp and skull defects can be either obvious or occult; over 300 cases have been reported in literature. Aplasia cutis congenita (ACC) is recognized as a heterogeneous disorder, all characterized by focal absence of the epidermis, dermis and sometimes the calvarium and/or dura. We present a case of ACC in an infant whose mother was exposed to a teratogenic drug (Methimazole - an antithyroid drug) during pregnanc...

  15. The role of diclofenack on inducing of aplasia cutis congenita: a case report

    OpenAIRE

    Pajaziti, Laura; Rexhepi, Syzana; Shatri-Muça, Ylfete; Ferizi, Mybera

    2009-01-01

    Background Aplasia cutis congenita is a disorder where e newborn child is missing skin from certain areas. It is a rare condition with no particular race or sex more at risk. May occur by itself or be associated with other physical syndromes or disorders. A classification system exists for aplasia cutis congenital consisting of 9 groups, based on the number and location of the skin defects and the presence or absence of other malformations. Causes of aplasia congenital could be heredity, tera...

  16. THE PURE RED BLOOD CELL APLASIA IN RENAL TRANSPLANT RECIPIENT

    Directory of Open Access Journals (Sweden)

    B. T. Dzumabaeva

    2011-01-01

    Full Text Available The pure red blood cell aplasia of renal transplant recipients caused by parvovirus B19 (PB19 is characterized by persistent anemia which resistant to erythropoietin therapy, lack of reticulocytes, bone marrow hypoplasia, and clinically accompanied by severe recurrent bacterial, fungal and viral infection. In case of reactivation PB19 it is necessarv, first of all, eliminate the causes activation of this virus and to cancel or reduce the dose of drugs which depressed the normal hematopoiesis germs, thus to reduce the pancytopenia associating complications in this population. 

  17. Pure red cell aplasia induced by epoetin zeta.

    Science.gov (United States)

    Panichi, Vincenzo; Ricchiuti, Guido; Scatena, Alessia; Del Vecchio, Lucia; Locatelli, Francesco

    2016-08-01

    Pure red cell aplasia (PRCA) may develop in patients with chronic kidney disease receiving erythropoiesis-stimulating agents (ESA). We report on a 72-year-old patient who developed hypo-proliferative anaemia unresponsive to ESA following the administration of epoetin zeta subcutaneously for 7 months. On the basis of severe isolated hypoplasia of the erythroid line in the bone marrow and high-titre neutralizing anti-erythropoietin antibodies (Ab), a diagnosis of Ab-mediated PRCA was made. Epoetin zeta was discontinued and the patient was given steroids. This was associated with anaemia recovery. To our knowledge this is the first PRCA case related to epoetin zeta. PMID:27478604

  18. Aplasia cutis congenita of the scalp: Therapeutic modalities

    Directory of Open Access Journals (Sweden)

    Shivakumar S

    2006-01-01

    Full Text Available Agenesis of scalp is an uncommon but well-recognized clinical entity. Congenital scalp and skull defects can be either obvious or occult; over 300 cases have been reported in literature. Aplasia cutis congenita (ACC is recognized as a heterogeneous disorder, all characterized by focal absence of the epidermis, dermis and sometimes the calvarium and/or dura. We present a case of ACC in an infant whose mother was exposed to a teratogenic drug (Methimazole - an antithyroid drug during pregnancy. This case report is presented to highlight the steps to successful management. Definitive full thickness scalp cover at the earliest avoids secondary infection, eschar formation and exsanguination.

  19. L’efficacité enseignante, quelle modélisation pour servir cette ambition ?

    OpenAIRE

    Clanet, Joël

    2013-01-01

    Cette contribution traite de l’« efficacité » de l’enseignement. La réflexion porte à la fois sur la définition du terme « efficacité » et sur les modèles qui permettent l’analyse des relations entre enseignement et apprentissage. À ce propos il y a lieu de distinguer les effets à court terme des effets à long terme, l’efficacité interne et l’efficacité externe. À partir de l’évocation de ses travaux axés sur les pratiques et les dispositifs, l’auteur propose un cadre théorique prenant en com...

  20. Pure red cell aplasia following autoimmune hemolytic anemia: An enigma

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    M Saha

    2013-01-01

    Full Text Available A 26-year-old previously healthy female presented with a 6-month history of anemia. The laboratory findings revealed hemolytic anemia and direct antiglobulin test was positive. With a diagnosis of autoimmune hemolytic anemia (AIHA, prednisolone was started but was ineffective after 1 month of therapy. A bone marrow trephine biopsy revealed pure red cell aplasia (PRCA showing severe erythroid hypoplasia. The case was considered PRCA following AIHA. This combination without clear underlying disease is rare. Human parvovirus B19 infection was not detected in the marrow aspirate during reticulocytopenia. The patient received azathioprine, and PRCA improved but significant hemolysis was once again documented with a high reticulocyte count. The short time interval between AIHA and PRCA phase suggested an increased possibility of the evolution of a single disease.

  1. APLASIA CUTIS CONGENITA SCALP PRESENTING WITH LIFE THREATENING HEMORRHAGE: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Farrukh Mahmood

    2012-01-01

    Full Text Available Aplasia cutis congenita is a rare congenital anomaly characterized by the absence of a patch of skin since birth. It may lead to life threatening complications at times. A 5-day-old neonate with Aplasia cutis congenita was received in a state of shock due to tremendous blood loss from the superior sagittal sinus. The neonate was resuscitated immediately followed by closure of the superior sagittal sinus and flap coverage to the defect as a life saving procedure.

  2. Pure red cell aplasia in a simultaneous pancreas-kidney transplantation patient: inside the erythroblast

    Directory of Open Access Journals (Sweden)

    Francesca Labbadia

    2012-09-01

    Full Text Available A case of pure red cell aplasia in a simultaneous kidney-pancreas transplant recipient on immunosuppressive therapy is reported here. The patient presented with anemia unresponsive to erythropoietin treatment. Bone marrow cytomorphology was highly suggestive of parvovirus pure red cell aplasia, which was confirmed with serology and polymerase chain reaction positive for parvovirus B19 DNA in peripheral blood. After the administration of intravenous immunoglobulin the anemia improved with a rising number of the reticulocytes.

  3. Uterine horn aplasia with complications in two mixed-breed bitches : case report

    OpenAIRE

    M.L. Schulman; L.A. Bolton

    1997-01-01

    Unilateral segmental uterine horn aplasia was found in 2 mixed-breed bitches. The 1st bitch was presented with clinical signs of acute abdominal pain, and pyometra was suspected. Pyometra was confirmed surgically with rupture of a blind-ending cranial portion of the anomalous right uterine horn, which had resulted in peritonitis. The 2nd bitch was presented for routine ovariohysterectomy. The right uterine horn was affected by segmental aplasia, with mucometra of the cranial portion of the af...

  4. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

    OpenAIRE

    E. Bulliorsky; C. Shanley; G. Stemmelin; J. Ceresetto; O. Rabinovich

    2002-01-01

    El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH) con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoy...

  5. Conférence sur l'efficacité

    CERN Document Server

    Jullien, François

    2005-01-01

    Philosophe et sinologue, François Jullien présente ici une conférence qu'il a prononcée auprès de chefs d'entreprise et dans le milieu du management. D'un côté, la conception européenne de l'efficacité est liée à la modélisation comme à la finalité et revendique l'action jusqu'à l'héroïsme ; de l'autre, la pensée chinoise de l'efficience, indirecte et discrète, s'appuie sur le potentiel de situation et induit des " transformations silencieuses ", sans éclat ni même événement. Par-delà cet écart, il s'agira d'interroger la nature de l'effectivité ; ou comment l'intervention humaine réussit à se brancher sur la propension des choses et s'y laisse intégrer. Ce propos se garde donc de séparer tant soit peu l'art d'opérer sur des situations et l'exercice de la philosophie ; en résultent des effets de lecture portant sur l'histoire du XXe siècle ainsi que la géopolitique - et géoéthique - à venir.

  6. Aggressive large cell lymphoma: early assessment of therapeutic efficacy by positron emission tomography; Lymphome agressif a grandes cellules: appreciation precoce de l'efficacite therapeutique par la TEP au [{sup 18}F]-FDG

    Energy Technology Data Exchange (ETDEWEB)

    Itti, E.; Maignan, M. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Medecine Nucleaire, 94 - Creteil (France); Haioun, C.; Reyes, F. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service d' Hematologie Clinique, 94 - Creteil (France); Rahmouni, A. [Hopital Henri-Mondor, AP-HP, Universite Paris-12, Service de Radiologie, 94 - Creteil (France)

    2004-07-01

    The international prognostic index is a well-established tool for stratifying patients with aggressive non-Hodgkin's lymphoma scheduled for tailored therapy. Early FDG-PET imaging could play a major predictive role for patient survival by providing functional information about lymphoma chemo-sensitivity. We present here the results of the interim analysis (about SD patients) of a prospective multi-centre study (national PHRC), the goals of which were to correlate PET response after 2 induction cycles 1) to the therapeutic response assessed by conventional diagnostic methods and 2) to event free survival and global survival. (author)

  7. Medullary aplasia secondary to an irradiation accident: Treatment options and evolution of the concepts; L'aplasie medullaire secondaire a un accident d'irradiation : options therapeutiques et evolution des concepts

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, T. [Service d' Hematologie, HIA Percy, et Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Fagot, T.; Souleau, B. [Service d' Hematologie, HIA Percy, Clamart (France); Dormont, D. [Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Nedellec, G. [Service d' Hematologie, HIA Percy, Clamart (France)

    2002-07-01

    Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods. (author)

  8. Marrow fat cell: response to x-ray induced aplasia

    International Nuclear Information System (INIS)

    Adipose tissue is an integral structural component of normal rabbit marrow and is believed to behave primarily as a cushion in response to hemopoietic proliferation, accommodating to changes in hemopoiesis by change in either size or number or both of the fat cells in order to maintain constancy of the marrow volume. To test this hypothesis, aplasia of the right femur of New Zealand white rabbits was induced by x irradiation with 8000 rads; the left unirradiated limb served as control. Twenty-four hours before sacrifice 50 μCi of palmitate-114C was administered intravenously and the marrow of both femurs removed. Samples of perinephric fat were taken for comparison. Fat cell volume, C14 palmitate turnover and fatty acid composition were determined. The total number of fat cells in the entire marrow of both femurs was calculated. The measurements showed no difference in size or fatty acid turnover of the fat cells in the irradiated aplastic marrow from the cells of the control marrow. The number of fat cells in both the irradiated and the unirradiated control femurs was essentially the same. These findings do not support the view that marrow fat cells respond to diminished hematopoiesis by either increase in their volume or number. In addition, the findings suggest that both marrow and subcutaneous fat cells are fairly resistant to high doses of x-ray irradiation

  9. Uterine horn aplasia with complications in two mixed-breed bitches : case report

    Directory of Open Access Journals (Sweden)

    M.L. Schulman

    1997-07-01

    Full Text Available Unilateral segmental uterine horn aplasia was found in 2 mixed-breed bitches. The 1st bitch was presented with clinical signs of acute abdominal pain, and pyometra was suspected. Pyometra was confirmed surgically with rupture of a blind-ending cranial portion of the anomalous right uterine horn, which had resulted in peritonitis. The 2nd bitch was presented for routine ovariohysterectomy. The right uterine horn was affected by segmental aplasia, with mucometra of the cranial portion of the affected horn. Histopathology demonstrated both uteri to have diffuse cystic endometrial hyperplasia. It is postulated that cystic endometrial hyperplasia, together with the congenital anomaly, resulted in pyometra in one case and in mucometra in the other case. This is believed to be the 1st report of uterine horn aplasia in the bitch in association with clinical signs and lesions other than infertility.

  10. A Patient with Unilateral Tibial Aplasia and Accessory Scrotum: A Pure Coincidence or Nonfortuitous Association?

    Directory of Open Access Journals (Sweden)

    Zoran Gucev

    2010-01-01

    Full Text Available Tibial aplasia is an uncommon lower limb malformation that can occur isolated or be part of a more complex malformation pattern. We describe a 9-year-old boy born after uneventful pregnancy and delivery. Family history was negative for maternal diabetes and other malformations. The patient presented with left tibial aplasia and homolateral prexial foot polydactyly. He also displayed enamel dysplasia and bifid scotum with cryptorchidism. Literature review failed to identify a significant syndromic association between lower limb defects of the tibial type and the genital anomalies reported here. The combination of tibial aplasia with midline genital malformations further supports the hypothesis that the tibial ray development mirrors the morphogenetic process of the radial structures. Accordingly, the malformation pattern observed in the present patient may be pathogenetically explained by an insult occurring during late blastogenesis.

  11. Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.

    Science.gov (United States)

    Copur, S; Dahut, W; Chu, E; Allegra, C J

    1995-02-01

    A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX). Skin rash involved regions of the face, lower abdomen, back, buttocks and both upper thighs. Biopsy of the skin rash demonstrated superficial perivascular lymphocytic infiltrate and was consistent with a drug reaction. Peripheral blood count revealed pancytopenia and a bone marrow biopsy was consistent with aplasia. Blood counts returned to normal 6 days after institution of granulocyte colony stimulating factor therapy. In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient. Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia. PMID:7538828

  12. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible Pure red cell aplasia after ABO incompatible bone marrow transplantation

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.ABO incompatibility in allogeneic bone marrow transplantation may be associated with incomplete or delayed erythroid engraftment, being pure red cell aplasia (PRCA the most severe complication in this setting. Attempts for the treatment of PRCA have been made with erythropoietin or with plasmapheresis with relative success, and some authors have reported the reversibility of PRCA with antilymphocyte globulin (ALG or ATG, based on the assumption that PRCA might be immunologically mediated. We report herewith a patient with acute leukemia who developed post - BMT pure red cell aplasia. His sibling donor (sister was HLA identical and ABO incompatible, having low agglutinin

  13. Congenital aplasia of the optic chiasm and esophageal atresia: a case report

    Directory of Open Access Journals (Sweden)

    Madonia Maurizio

    2011-08-01

    Full Text Available Abstract Introduction The complete absence of the chiasm (chiasmal aplasia is a rare clinical condition. Hypoplasia of the optic nerve and congenital nystagmus are almost invariably associated characteristics. Microphthalmos or anophthalmos are common features in chiasmal aplasia, while central nervous system abnormalities are less frequent. Esophageal atresia can be isolated or syndromic. In syndromic cases, it is frequently associated with cardiac, limb, renal or vertebral malformations and anal atresia. More rarely, esophageal atresia can be part of anophthalmia-esophageal-genital syndrome, which comprises anophthalmia or microphthalmia, genital abnormalities, vertebral defects and cerebral malformations. Here, a previously unreported case of chiasmal aplasia presenting without microphthalmos and associated with esophageal atresia is described. Case presentation Aplasia of the optic chiasm was identified in a Caucasian Italian 8-month-old boy with esophageal atresia. An ultrasound examination carried out at 21 weeks' gestation revealed polyhydramnios. Intrauterine growth retardation, esophageal atresia and a small atrial-septal defect were subsequently detected at 28 weeks' gestation. Repair of the esophageal atresia was carried out shortly after birth. A jejunostomy was carried out at four months to facilitate enteral feeding. The child was subsequently noted to be visually inattentive and to be neurodevelopmentally delayed. Magnetic resonance imaging revealed chiasmal aplasia. No other midline brain defects were found. His karyotype was normal. Conclusion If achiasmia is a spectrum, our patient seems to depict the most severe form, since he appears to have an extremely severe visual impairment. This is in contrast to most of the cases described in the literature, where patients maintain good--or at least useful-- visual function. To the best of our knowledge, the association of optic nerve hypoplasia, complete chiasmal aplasia, esophageal

  14. Reticulocyte maturity index by flow cytometry: its applicability in radioinduced bone marrow aplasia

    International Nuclear Information System (INIS)

    Flow cytometric reticulocyte quantification was assayed in ten patients undergoing bone marrow transplantation (BMT) with previous conditioning chemotherapy and total body irradiation (TBI). A reticulocyte maturity index (RMI) was determined taking into account the RNA content. With de aim of testing the utility of RMI as an early predictor of functional recovery in marrow aplasia, other haematological indicators as neutrophils count were comparatively evaluated. Mean time elapsed between BMT and engraftment evidence by RMI was 17,6 days. In six patients the RMI was the earliest indicator of functional recovery. The applicability of this assay in the following of radioinduced bone marrow aplasia is discussed. (author). 4 refs., 4 figs., 2 tabs

  15. Chronic renal failure due to unilateral renal agenesis and total renal dysplasia (=aplasia)

    International Nuclear Information System (INIS)

    Three adult patients with unilateral renal agenesis/total dysplasia (= aplasia) and with an early chronic renal failure are presented. One patient had renal agenesis without ureter bud and ureteric ostium on one side, and reflux pyelonephritis on the other; one had small compact total renal dysplasia (= aplasia) on one side, while chronic uric acid nephropathy (chronic renal disease as a cause of gout) was diagnosed on the other; the third patient had a total large multicystic dysplasia on one side, and on the other a segmental large multicystic dysplasia. Radiological steps and radiodiagnostic criteria are discussed and the combination of urogenital and extraurogenital anomalies is referred to. (orig.)

  16. Chronic renal failure due to unilateral renal agenesis and total renal dysplasia (=aplasia)

    Energy Technology Data Exchange (ETDEWEB)

    Kroepelin, T.; Ziupa, J.; Wimmer, B.

    1983-05-01

    Three adult patients with unilateral renal agenesis/total dysplasia (= aplasia) and with an early chronic renal failure are presented. One patient had renal agenesis without ureter bud and ureteric ostium on one side, and reflux pyelonephritis on the other; one had small compact total renal dysplasia (= aplasia) on one side, while chronic uric acid nephropathy (chronic renal disease as a cause of gout) was diagnosed on the other; the third patient had a total large multicystic dysplasia on one side, and on the other a segmental large multicystic dysplasia. Radiological steps and radiodiagnostic criteria are discussed and the combination of urogenital and extraurogenital anomalies is referred to.

  17. Holoprosencephaly and Pure Red Cell Aplasia in a Feline Leukaemia Virus-Positive Kitten.

    Science.gov (United States)

    Southard, T L; Rodriguez-Ramos Fernandez, J; Priest, H; Stokol, T

    2016-01-01

    A 9-month-old, female, domestic longhair cat with severe anaemia tested positive for feline leukaemia virus (FeLV) and was humanely destroyed and submitted for necropsy examination. Gross findings included a non-divided rostral telencephalon, consistent with semilobar holoprosencephaly. Histological examination of the bone marrow revealed an almost complete absence of erythroid precursor cells, consistent with pure red cell aplasia, and mild to moderate myelofibrosis. This case demonstrates a very unusual central nervous system defect, as well as an atypical presentation of pure red cell aplasia, in a FeLV-positive kitten. PMID:26897097

  18. Flow cytometric of reticulocytes quantification: radio-induction medullary aplasia application

    International Nuclear Information System (INIS)

    Flow cytometric reticulocyte quantification was assayed in ten patients undergoing bone marrow transplantation (BMT) with previous conditioning by chemotherapy and total body irradiation. A reticulocyte maturity index (RMI) was determined taking into account the RNA content. With the aim of testing the utility of RMI as an early predictor of functional recovery in marrow aplasia, other hematological indicators as neutrophils count were comparatively evaluated. Mean time elapsed between BMT and engraftment evidence by RMI was 17,6 days. In six patients the RMI was the earliest indicator of functional recovery. The applicability of this assay in the pursuit of radioinduced bone marrow aplasia is discussed. (authors). 4 refs., 4 figs., 2 tabs

  19. Reconstruction of bilateral tibial aplasia and split hand-foot syndrome in a father and daughter

    Directory of Open Access Journals (Sweden)

    Ali Al Kaissi

    2014-01-01

    Full Text Available Background: Tibial aplasia is of heterogeneous aetiology, the majority of reports are sporadic. We describe the reconstruction procedures in two subjects - a daughter and father manifested autosomal dominant (AD inheritance of the bilateral tibial aplasia and split hand-foot syndrome. Materials and Methods: Reconstruction of these patients required multiple surgical procedures and orthoprosthesis was mandatory. The main goal of treatment was to achieve walking. Stabilization of the ankle joint by fibular-talar-chondrodesis on both sides, followed by bilateral Brown-procedure at the knee joint level has been applied accordingly. Results: The outcome was with improved function of the deformed limbs and walking was achieved with simultaneous designation of orthotic fitting. Conclusion: This is the first study encompassing the diagnosis and management of a father and daughter with bilateral tibial aplasia associated with variable split hand/foot deformity without foot ablation. Our patients showed the typical AD pattern of inheritance of split-hand/foot and tibial aplasia.

  20. RETREATMENT WITH FLUDARABINE AND CYCLOSPORINE FOR ONE CASE OF REFRACTORY PURE RED CELL APLASIA

    Institute of Scientific and Technical Information of China (English)

    Guang-sheng He; Xiang Zhang; De-pei Wu; Ai-ning Sun; Miao Miao; Xiu-li Wang; Zheng-ming Jin

    2008-01-01

    @@ MANY cases of pure red cell aplasia (PRCA) were mediated by over-function of immune cells, and responded well to immunosuppres-sive therapy.1 Sometimes refractory cases also arose. Fludara-bine is an analogue of adenosine resistant to deamination which is widely used for B-chronic lymphocytic leukemia (CLL) and other hematological malignancies.

  1. APLASIA CUTIS CONGENITAL WITH AMNIOTIC BAND DISRUPTION COMPLEX: A RARE CASE REPORT

    Directory of Open Access Journals (Sweden)

    Pradipprava

    2015-09-01

    Full Text Available Aplasia cutis congenita (ACC is congenital absence of skin, most commonly affecting scalp. Etiology is multifactorial like intrauterine infection, teratogens, vascular causes, genetic syndromes etc. We here represent an infant with ACC involving extremities and associated with amniotic band disruption complex. He was treated conservatively and discharged.

  2. Extensa falha cutânea e craniana em paciente com aplasia cutis congenita Large scalp and skull defect in patient with aplasia cutis congenita

    Directory of Open Access Journals (Sweden)

    José Gilberto de Brito Henriques

    2004-12-01

    Full Text Available Aplasia cutis congenita (ACC é doença rara, caracterizada pela ausência de formação completa da pele. Geralmente ocorre no couro cabeludo, na linha mediana, e apresenta-se ao nascimento como uma ferida ulcerada que pode atingir diferentes profundidades e envolver o periósteo, crânio e dura-máter. Descrevemos o caso de menina recem-nascida que apresentava fácies dismórfica com defeito no couro cabeludo que abrangia a quase totalidade da abóbada craniana e apresentava falha óssea desde a base dos ossos frontais até os occipitais e mastóides. A dura-máter estava em sua maior parte exposta, sem sinais de fissuras. Devido à raridade da ACC e ao pequeno número de pacientes nas séries publicadas na literatura a padronização do tratamento ainda é incipiente. O que existem são recomendações. Ainda são necessários estudos que abordem desde a etiologia da doença até a avaliação dos métodos de tratamento e evolução de grupos maiores de pacientes.Aplasia cutis congenita is a rare condition characterized by the absence of skin layers. It is most common on the scalp, middle line, and it can be seen as a congenital ulcer involving periosteum, skull and dura. We present the case of a female newborn infant with a dysmorphic facies, a large scalp and skull defect exposing the dura. There was no cerebrospinal fluid leakage. The rarity of cases with large defects and small series reported make difficult to determinate the ideal treatment for aplasia cutis congenita. More studies are necessary to define the etiology and best management of this patients.

  3. [Bilateral deep venous thrombosis and vena cava aplasia treated with local thrombolysis

    DEFF Research Database (Denmark)

    Pelta, A.M.; Jørgensen, Maja; Just, Sven Richardt Lundgren; Jensen, Leif Pandora

    2008-01-01

    In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete thr...... thrombus resolution and no valvular incompetence at three months follow-up. In our opinion this treatment should be offered even in complex cases of acute proximal deep venous thrombosis Udgivelsesdato: 2008/5/19......In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete...

  4. Pulmonary Sequestration with Renal Aplasia and Elevated SUV Level in PET/CT

    Directory of Open Access Journals (Sweden)

    Serdar Şen

    2012-01-01

    Full Text Available Extralobar sequestration with other bronchopulmonary malformations is commonly seen; however, the association of extralobar sequestration with renal aplasia is very rare. A 75-year-old female patient was admitted with back pain. Ultrasonography revealed aplasia of the left kidney and tomography showed 6×4.5 cm sized tumor in the left hemithorax at the posterobasal area. The lesion has focally increased glycolytic activity (SUVmax: 3.2 at the left upper pole on positron emission tomography scan (PET/CT. Sequestrectomy was performed after the confirmation by frozen section that the lesion was benign and of extrapulmonary sequestration. No complication occurred during postoperative and 50-month follow-up period.

  5. Segmental aplasia of the uterine horn with ipsilateral renal agenesis in a cat.

    Science.gov (United States)

    Chang, Jinhwa; Jung, Joo-hyun; Yoon, Junghee; Choi, Min-cheol; Park, Jae Hak; Seo, Kang-Moon; Jeong, Seong Mok

    2008-06-01

    A nine-month-old domestic short haired cat was admitted with the history of acute vomiting, depression and shivering. Abdominal ultrasonography revealed minimum enlargement of the right uterine horn filled with anechoic fluid. On excretory urography, functionally and anatomically normal, enlarged left kidney was found, but right kidney was absent. It was preliminary diagnosed as hydrometra with right renal agenesis. Aiming at the correction of hydrometra, we performed ovariohysterectomy. During spaying, we found a missing segment of distal part of the right uterine horn and absence of ipsilateral kidney and ureter. Compressed uterine structure and segmental aplasia of right uterine horn were found in histopathological investigation. Taken together, it was diagnosed as a segmental aplasia of uterine horn with ipsilateral renal agenesis. PMID:18628611

  6. Anti-Erythropoietin Antibody Associated Pure Red Cell Aplasia Resolved after Liver Transplantation

    OpenAIRE

    Hung, Annie K.; Jennifer Guy; Behler, Caroline M.; Lee, Eugene E.

    2015-01-01

    Patients undergoing antiviral therapy for chronic hepatitis C often develop anemia secondary to ribavirin and interferon. Recombinant erythropoietin has been used to improve anemia associated with antiviral therapy and to minimize dose reductions, which are associated with decreased rates of sustained virologic response. A rare potential side effect of recombinant erythropoietin is anti-erythropoietin antibody associated pure red cell aplasia. In chronic kidney disease patients with this enti...

  7. Etanercept-Associated Transient Bone Marrow Aplasia: A Review of the Literature and Pathogenetic Mechanisms

    OpenAIRE

    Kozak, Natasha; Friedman, Joshua; Schattner, Ami

    2014-01-01

    A patient with rheumatoid arthritis presented with increasing fatigue, fever, gingival bleeding, and petechial rash. Her symptoms started 1 week after the first injection of etanercept (Enbrel). Her only other medications (methotrexate and hydroxychloroquine) had been unchanged for years. Tests revealed severe pancytopenia and bone marrow aplasia. She recovered with supportive treatment within 12 days. The literature on serious blood dyscrasias associated with anti-tumor necrosis factor-α the...

  8. Actualites therapeutiques en pneumologie

    OpenAIRE

    Louis, Renaud; Bosquee, Léon; DUYSINX, Bernard; Corhay, Jean-Louis

    2007-01-01

    We review what we think to be the major advances in the field of respiratory medicine over the last ten years. We concentrate here on four major diseases i.e. asthma, chronic obstructive pulmonary disease (COPD), lung cancer and chronic respiratory insufficiency due to restrictive disorders. Therapeutic advances are based either on new drugs or on new disease management concepts and, in some cases, on new medical devices. These advances have allowed a reduction in mortality and morbidity in a...

  9. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells; Approches therapeutiques du syndrome hematopoietique apres irradiation globale accidentelle grave. Interet de l`expansion ex vivo des cellules hematopoietiques

    Energy Technology Data Exchange (ETDEWEB)

    Thierry, D.

    1994-12-31

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too.

  10. Les secrets de l'efficacité en faire plus... en moins de temps

    CERN Document Server

    Savoyat, Bruno

    2006-01-01

    Comment gagner en efficacité grâce à une meilleure organisation et à une utilisation plus performante de l'informatique. Ce livre, rédigé par un spécialiste internationalement reconnu des méthodes d'optimisation du travail, vous fournit £ une méthode de hiérarchisation des tâches et 0 les règles qui vous permettront d'acquérir une meilleure organisation personnelle et collective. Il montre également % comment utiliser au mieux les outils informatiques (Internet, Intranet, groupware) pour parvenir à gagner en efficacité au bureau. Parce que les techniques qu'il propose ont été appliquées avec succès par plus d'1 million de personnes dans le monde, ce livre vous aidera vraiment. Grâce à ce livre vous apprendrez à : ° Mieux gérer votre emploi du temps en fonction de vos priorités, de vos responsabilités et de vos objectifs en établissant votre «carte de responsabilités» et en apprenant à déléguer. ° Mieux organiser le rangement des documents sur votre bureau, dans votre messag...

  11. A case of severe congenital kyphoscoliosis secondary to multiple bilateral thoracic pedicle aplasia

    Energy Technology Data Exchange (ETDEWEB)

    Geoffray, Anne; Leloutre, Beatrice; Albertario, Marco; Bechard-Sevette, Nancy [Fondation Lenval Children' s Hospital, Department of Pediatric Imaging, Nice (France); Clement, Jean-Luc [Fondation Lenval Children' s Hospital, Department of Orthopedic and Spine Surgery, Nice (France)

    2008-07-15

    A 9-month-old boy with congenital kyphoscoliosis secondary to multiple bilateral thoracic pedicle aplasias is presented. This anomaly has rarely been described in the literature. Plain films showed absence of thoracic pedicles bilaterally from T2 to T9, which was better demonstrated on CT multiplanar and 3-D reformatted images. There were no neurological symptoms even though the deformity progressed rapidly. Congenital kyphosis or kyphoscoliosis is often related to spinal anomalies that are located on the anterior aspect of the vertebrae. However, posterior anomalies may also be responsible and should be recognized before neurological complications occur. (orig.)

  12. [Aplasia and hypoplasia of the side of the nose in the Mocha Period and today].

    Science.gov (United States)

    Pirsig, W

    1989-01-01

    In earthenware vessels from the Moche period (200-700 A.D.) pathological findings of nasal deformities have been depicted in a realistic manner. By means of two recent casuistics and of two portrait vessels of Old Peru it is demonstrated how exactly the nasal pathology was observed by the artists of the Moche period. The first example shows a unilateral hypoplasia of the nasal ala due to injury in early childhood, the second example shows a bilateral aplasia of the nasal alae due to an intrauterine growth disturbance. PMID:2690796

  13. Prenatal ultrasonography of trisomy 18 with radial aplasia: A case report

    International Nuclear Information System (INIS)

    Trisomy 18 (Edward syndrome) is the second most common chromosomal anomaly of the autosomal trisomy. Prenatal diagnosis of trisomy 18 is extremely important because of the complex malformations and lethal prognosis. Prenatal sonographic findings at 17 weeks of gestation showing radial aplasia with upper limb contracture, omphalocele, and suspicious esophageal atresia suggested the diagnosis and led to amniocentesis. Karyotyping revealed trisomy 18 (47 XX, +18, and characteristic autopsy findings were identified. We report a case of prenatally diagnosed trisomy 18 with a review of literatures.

  14. Prenatal ultrasonography of trisomy 18 with radial aplasia: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jee Young; Lee, Yeon Hee [Dankook University College of Medicine, Seoul (Korea, Republic of)

    2002-06-15

    Trisomy 18 (Edward syndrome) is the second most common chromosomal anomaly of the autosomal trisomy. Prenatal diagnosis of trisomy 18 is extremely important because of the complex malformations and lethal prognosis. Prenatal sonographic findings at 17 weeks of gestation showing radial aplasia with upper limb contracture, omphalocele, and suspicious esophageal atresia suggested the diagnosis and led to amniocentesis. Karyotyping revealed trisomy 18 (47 XX, +18, and characteristic autopsy findings were identified. We report a case of prenatally diagnosed trisomy 18 with a review of literatures.

  15. Pure red cell aplasia due to azathioprine therapy for Crohn′s disease

    Directory of Open Access Journals (Sweden)

    Nagesh Kamath

    2016-01-01

    Full Text Available Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD, drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA therapy are well documented, but drug-associated pure red cell aplasia (PRCA is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn′s disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.

  16. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    OpenAIRE

    E. Bulliorsky; C. Shanley; G. Stemmelin; J. Ceresetto; O. Rabinovich

    2002-01-01

    El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH) con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoy...

  17. Le sentiment d'efficacité : approche empirique auprès de professionnels de la santé en France et en Suisse

    OpenAIRE

    Piguet, Catherine; Nagels, Marc

    2006-01-01

    Cette communication s'intéresse à l'auto-efficacité individuelle de soignants, de cadres de santé et de directeurs des soins, en Suisse et en France. Une même échelle de mesure de l'auto-efficacité a été utilisée dans ces deux pays et au sein d'une même filière professionnelle soignante. L'auto-efficacité individuelle et collective est comprise comme un facteur de développement de compétences et de construction de trajectoires professionnelles. La relation est faite entre auto-efficacité et a...

  18. Introduction : sentiments d’efficacité personnelle et orientation scolaire et professionnelle1

    OpenAIRE

    Blanchard, Serge

    2011-01-01

    Ce numéro spécial poursuit quatre objectifs : Présenter la théorie des sentiments d’efficacité personnelle (SEP) – qui s’insère dans le cadre plus général de la théorie sociale cognitive (TSC) d’Albert Bandura – et les principaux résultats des recherches qu’elle a suscitées depuis vingt-cinq ans aux États-Unis dans le domaine de l’orientation scolaire et professionnelle.L’article de Stephen Brewer présente d’abord une biographie d’Albert Bandura puis une brève introduction à ses travaux. Il d...

  19. Aplasia pura de serie roja post-trasplante alogeneico de células progenitoras hematopoyeticas ABO incompatible

    Directory of Open Access Journals (Sweden)

    E. Bulliorsky

    2002-12-01

    Full Text Available El trasplante alogeneico de células progenitoras hematopoyéticas (TCPH con incompatibilidad ABO entre el donante y el receptor puede en ocasiones asociarse a trastornos en la progenie eritroide desarrollada a partir de la médula ósea trasplantada, caracterizado por un funcionamiento tardío, inadecuado e incompleto de la misma. En este contexto, la aplasia pura de serie roja es la complicación más severa. Se han intentado tratamientos para la aplasia pura de serie roja post-TCPH con eritropoyetina o plasmaféresis, con relativo éxito. Algunos autores han informado también la utilización de globulina antilinfocitaria, asumiendo que dicha aplasia selectiva de la serie roja en la médula ósea trasplantada es mediada por un mecanismo inmune. En este trabajo se describe un paciente portador de una leucemia aguda en quien se realizó un TCPH alogeneico (ABO incompatible con su donante. Teniendo niveles bajos de aglutininas contra el grupo sanguíneo de la donante, desarrolló una aplasia pura de serie roja post - TCPH. La misma no mejoró con tratamiento con eritropoyetina o con un refuerzo de progenitores hematopoyéticos de sangre periférica de la misma donante (boost, resolviéndose totalmente luego de un tratamiento exitoso con globulina antilinfocitaria de origen equino.

  20. New experimental approach to treatment of radiation-induced bone marrow aplasia: ex vivo expansion of hematopoietic cells

    International Nuclear Information System (INIS)

    The management of bone marrow aplasia secondary to accidental exposure to high doses of ionizing radiations requires new therapeutic protocols in addition to cytokine therapy. The in vitro incubation of hematopoietic stem and progenitor cells from irradiated nonhuman primates with negative and positive regulators of hematopoiesis may lead to helpful products of transfusion. (author)

  1. Post renal transplant pure red cell aplasia-is tacrolimus a culprit?

    Science.gov (United States)

    Patil, Malagouda R; Choudhury, Arpita Roy; Chohwanglim, Manong; Divyaveer, Smita; Mahajan, Chetan; Pandey, Rajendra

    2016-08-01

    Anemia is not uncommon in the post-renal transplant period and has been reported in up to 40% of renal transplant recipients. It is commonly due to drugs and infections. While post-transplantation anemia is usually due to graft dysfunction and drugs such as mycophenolate and cotrimoxazole, tacrolimus is an uncommon cause. Tacrolimus is usually not believed to be significantly myelosuppressive, but it can cause anemia due to thrombotic microangiopathy. A literature review shows a very small number of reported cases of pure red cell aplasia (PRCA) where tacrolimus seemed to be a causative agent. We report a case series of three renal transplant recipients who were on tacrolimus and presented with chronic transfusion requiring anemia due to PRCA. PMID:27478605

  2. Aplasia cutis congenita of the scalp with large underlying skull defect: a case report

    International Nuclear Information System (INIS)

    Localised agenesis of the scalp is the most frequent patern in aplasia cutis congenita (ACC), a congenital absence of the skin and occasionally of deeper layers. Several clinical groups are characterised by the location and pattern of skin defects, associated malformations and the mode of inheritance. Death occurs in 20 % of cases, secondary to the associated anomalies, to infections or to haemorrhage from ulceration of the sagittal sinus when there is also a defect of the underlying skull. In this latter case, we close the defect by two rotational scalp flaps (Orticochea technique) at birth. A three-dimensional CT study is useful for showing the extent of the skull defect and the deformity of the craniofacial complex and the changes in the bone after treatment. (orig.)

  3. Recurrence of thymoma with pleural invasion in a patient with myasthenia gravis and pure red blood cell aplasia: a case report

    International Nuclear Information System (INIS)

    Thymoma are thymic tumors that arise from epithelial cells, they have different morphological characteristics. It is known for its association with autoimmune diseases such as myasthenia gravis, pure red cell aplasia, systemic lupus erythematosus, or hipogamaglobulinemia pemphigus foliaceus. The association thymoma-myasthenia gravis-pure red cell aplasia is a rare one; there will be a case report with the corresponding discussion and review of the literature

  4. Incidental finding of unilateral isolated aplasia of serratus anterior muscle and winged scapula on chest radiograph: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Joon Sung; Park, Hyun Jin; Ko, Jeong Min [Dept. of Radiology, St. Vincent' s Hospital, College of Medicine, The Catholic University of Korea, Suwon (Korea, Republic of)

    2014-10-15

    The isolated aplasia of the serratus anterior muscle with winging of scapula is very rare, and only a few cases are reported. Here, we present a case of a 30-year-old Korean male who initially presented with a left flank pain. His physical exam did not show any significant finding in his right shoulder. However, his chest radiograph showed absence of right serratus anterior muscle and slightly elevated and medially rotated right scapula. Subsequent CT scan showed the right serratus anterior muscle aplasia and medial winging of the right scapula. This case is unique in two aspects. First, the combination of abnormalities is different from the typical congenital abnormalities involving shoulder girdle, such as Sprengel deformity or Poland syndrome. Secondly, this was incidentally diagnosed with chest radiograph, without clinical impression. Careful reading of chest radiograph can help the radiologists to detect such clinically silent abnormalities.

  5. MURCS (Müllerian duct aplasia-renal agenesis-cervicothoracic somite dysplasia): a rare cause of primary amenorrhoea.

    Science.gov (United States)

    Kumar, Sunil; Sharma, Shruti

    2016-04-01

    The agenesis of the Müllerian duct is the second most common cause of primary amenorrhoea after Turner syndrome. The abnormal development of Müllerian duct often associates with the urinary tract and skeletal abnormalities. MURCS (Müllerian duct aplasia-renal agenesis-cervicothoracic somite dysplasia) association is a unique and rare developmental disorder with four common features of uterine hypoplasia or aplasia, renal agenesis or ectopy, vertebral anomalies and short stature. We report a case of young female with primary amenorrhoea. She had well-developed secondary sexual characteristics along with multiple congenital developmental abnormalities such as the absence of uterus, ectopic kidney, cervical vertebral fusion, hemivertebrae, scoliosis, cervical rib, facial asymmetry and growth retardation. Our case highlights the rarity and clinical importance of this syndrome. For the evaluation of primary amenorrhoea in a female with well-developed secondary sexual characteristics, congenital anomalies should be ruled out before hormone and karyotype analyses. PMID:27099773

  6. Incidental finding of unilateral isolated aplasia of serratus anterior muscle and winged scapula on chest radiograph: A case report

    International Nuclear Information System (INIS)

    The isolated aplasia of the serratus anterior muscle with winging of scapula is very rare, and only a few cases are reported. Here, we present a case of a 30-year-old Korean male who initially presented with a left flank pain. His physical exam did not show any significant finding in his right shoulder. However, his chest radiograph showed absence of right serratus anterior muscle and slightly elevated and medially rotated right scapula. Subsequent CT scan showed the right serratus anterior muscle aplasia and medial winging of the right scapula. This case is unique in two aspects. First, the combination of abnormalities is different from the typical congenital abnormalities involving shoulder girdle, such as Sprengel deformity or Poland syndrome. Secondly, this was incidentally diagnosed with chest radiograph, without clinical impression. Careful reading of chest radiograph can help the radiologists to detect such clinically silent abnormalities.

  7. Ex vivo expansion of haematopoietic cells in the treatment of accidental irradiation-induced aplasia. Feasibility Studies

    International Nuclear Information System (INIS)

    The lessons learnt from the treatment of previous radiation accidents using either bone marrow transplantation or growth factor therapy suggest that it is of importance to investigate new therapeutic regiments. Ex vivo expansion of haematopoietic stem cells, precursors and differentiated cells is a new approach of growth factor therapy which may be of interest for the treatment of patients with irradiation-induced bone marrow aplasia. Ex vivo expanded maturing cells could be used to limit the early risks bound to aplasia (infections related to granulocytopaenia, bleedings associated with thrombocytopaenia), whereas expanded immature cells could hasten haematopoietic recovery. Indeed, it is possible to culture from the blood or bone marrow the cells able to proliferate and differentiate. A sufficient quantity of cells to cover the transfusion needs of a radiation victim through an aplasia episode can be produced, in presence of a specific growth factor combination. Qualitative studies shows that the expanded cells exhibit a close to normal functionality. Long-term culture techniques demonstrate the expansion of immature cells. We have set up a high dose total body irradiation non-human primate model in order to study the therapeutic potential of ex vivo expansion of autologous progenitors and differentiating cells. All the steps of the process (sampling, positive selection of the immature cells, ex vivo expansion, irradiation of the animals, reinjection of the cultured cells and study of the outcome) are established. In order to allow the long term follow up of the ex vivo expanded haematopoietic cells (homing to the bone marrow or localization to specific organs for example), a retroviral gene transfer technique for transduction of green fluorescence protein (GFP) gene toward the selected immature blood or bone marrow cells is under development in this model. Taken together these elements will allow establishing the feasibility of ex vivo expansion of

  8. High dose ionizing irradiation induces an early and transient increase in peripheral blood hematopoietic progenitor cells; L`exposition aigue aux radiations ionisantes induit un recrutement transitoire des progeniteurs hematopoietiques au niveau du sang peripherique: implications therapeutiques potentielles

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Vetillard, J.; Chauvelot, F.; Thierry, D.; Mestries, J.C.; Herodin, F. [Centre de Recherches du Service de Sante des Armees, La Tronche, 38 - Grenoble (France)]|[Centre de Recherches du Service de Sante des Armees - Centre d`Etudes Nucleaires de Fontenay-aux-Roses, 92 (France)

    1997-12-31

    Nonhuman primates exposed to ionizing radiation exhibit an early and transient increase in peripheral blood committed hematopoietic progenitor cells. The management of bone marrow aplasia secondary to accidental irradiation could be based in part on the re-infusion of those circulating autologous progenitors following a period of ex vivo expansion with cytokines. (authors)

  9. Aplasia transitória da série vermelha na anemia falciforme Transient red cell aplasia in sickle cell disease

    Directory of Open Access Journals (Sweden)

    Mônica P. A. Veríssimo

    2007-09-01

    Full Text Available A doença falciforme, devido à vida média encurtada das hemácias, pelo quadro de hemólise crônica, pode apresentar um quadro clínico grave de anemia quando ocorre supressão da eritropoese devida à infecção pelo Parvovírus humano B19. O quadro clínico apresenta-se com febre, que pode preceder a anemia grave, fraqueza e mal- estar, além de sinais laboratoriais como queda da hemoglobina e reticulocitopenia importante. Diagnóstico laboratorial pode ser por imunofluorescência ou ensaio enzimático. O tratamento é a transfusão de concentrado de hemácias. Pode haver complicações associadas a esta infecção, tais como seqüestro esplênico, seqüestro hepático, síndrome torácica aguda, síndrome nefrótica, meningoencefalite e acidente vascular cerebral. Estratégias de prevenção poderão mudar a morbi-mortalidade desta condição no paciente portador de doença falciforme.Sickle cell disease due to shortened life span of red blood cells by hemolysis, may present with severe anemia when erythropoietic suppression occurs due to infection by the Human parvovirus B19. The clinical presentation presents with fever, which may precede transient red cell aplasia, as well as laboratorial signs such as a drop in hemoglobin and significant reticulo cytopenia. Laboratorial diagnosis may be by immunofluorescence or enzymatic assays. Treatment is achieved by transfusion of packed red blood cells. Complications may be associated to this infection, including splenic and hepatic sequestration, acute chest syndrome, nephrotic syndrome, meningoencephalitis and strokes. Strategies of prevention are able to change the morbidity and mortality of this condition in sickle cell disease patients.

  10. Absence of Clinical and Hemodynamic Consequences due to Posterior Tibial Artery Congenital Aplasia

    Directory of Open Access Journals (Sweden)

    Georgios Karaolanis

    2015-01-01

    Full Text Available The exact knowledge of popliteal artery and its branches’ anatomic variations is important for the clinical practice of angiology, vascular surgery, and interventional procedures. Congenital absence of the artery leads, in some cases, to early malformations of the extremity in the childhood; however, it may also remain asymptomatic. We present an unusual case of a 76-year-old male patient complaining of paraesthesia in both limbs and bilateral aplasia of posterior tibial artery (PTA. Physical examination, ankle-brachial indexes, before and after exercise, arterial duplex scan, and magnetic resonance arteriography were performed. Arterial pulses for PTA at the level of the ankle were normal; arterial duplex study showed biphasic arterial flow at the level of the ankle. Color duplex ultrasound as well as magnetic resonance arteriography revealed the absence of the PTA in both limbs. The vascularization of the fibula was bilaterally normal. The patient underwent also neurological examination and electromyography, which were normal. The evaluation of the possible clinical signs and symptoms and the hemodynamic consequences of this condition are further discussed.

  11. Spontaneous hematologic recovery from bone marrow aplasia after accidental tenfold overdosage with radiophosphorus

    Energy Technology Data Exchange (ETDEWEB)

    Gmuer, J.; Bischof, B.; Coninx, S.; Bucher, U.; Poretti, G.; Henrichs, K.; Kaul, A.; Roedler, H.D.; Buettner, K.; Frick, P.G.

    1983-04-01

    Two patients with polycythemia vera received intravenously an accidental tenfold overdosage of radiophosphorus therapy (60 and 50 mCi 32P, respectively). In both patients, the occurrence of hemorrhagic complications 3 wk after the 32P medication led to detection of the error and referral to our hospital. Upon admission they showed an agranulocytosis, severe thrombocytopenia, and bone marrow aplasia. In both cases, spontaneous recovery of the hematopoiesis was observed from day 40 posttreatment onward. In one patient, a slow but ultimately complete normalization of blood counts and marrow morphology took place, whereas in the other, a mild thrombocytopenia persists. Nearly 5 yr after the accidental overdosage, both patients are clinically well. Symptoms of polycythemia vera have not reappeared up to now. Attempts were made to evaluate the radiation dose absorbed by the bone marrow. In the first patient, the daily 32P excretion was determined from day 22 to day 60, whereas in the other patient a whole body count was performed on day 78 after administration. From these results, an approximate cumulative bone marrow dose of 10 Sv (1000 rem) could be calculated.

  12. Unilateral multifocal testicular biopsies in 320 patients with germ cell aplasia

    Directory of Open Access Journals (Sweden)

    D Jamali Zavareii. M

    2007-05-01

    Full Text Available Background: Germ cell aplasia (G.C.A is one of the most important testicular causes of infertility and azospermia.In this condition the seminiferous tubules are only lined by a single layer of sertoli cell. In some cases, there is focal area with spermatogenic activity. Methods: We studied infertile men with G.C.A referred to Jahade Daneshgahi of Iran during 1381-82, retrospectively. All the cases had more than one biopsy of one testis. Results: In 11.6٪ of 320 cases, comparison of multiple biopsy sites of a testis revealed: when one site showed G.C.A, another site revealed areas with spermatogenic activity. Considering the cases who showed germ cells in both sites, 15.3٪ of cases multiple biopsy sites appeared to have focal spermatogenesis, better maturation of germ cells or higher scoring area for urologic operation. Conclusion: According to new techniques in treatment of infertility with ICSI (intra cytoplasmic sperm injection in which fertility is possible with one spermatozoa or even spermatid (after recovery, biopsy of multiple sites instead of only one site is highly recommended in azospermic patient.

  13. Epoetin-associated pure red cell aplasia: past, present, and future considerations

    Science.gov (United States)

    McKoy, June M.; Stonecash, Robin E.; Cournoyer, Denis; Rossert, Jerome; Nissenson, Allen R.; Raisch, Dennis W.; Casadevall, Nicole; Bennett, Charles L.

    2009-01-01

    BACKGROUND Since 1988, millions of patients have received epoetin products intravenously (IV) and subcutaneously. In 1998, epoetin-associated pure red cell aplasia (PRCA) was first reported and causation was attributed to formulations without human serum albumin (HSA), subcutaneous administration, and uncoated rubber stoppers. STUDY DESIGN AND METHODS Data on erythropoietin (EPO)-associated PRCA were obtained from the Food and Drug Administration (FDA), regulatory authorities in other countries, and the manufacturers of epoetin alfa, epoetin beta, and darbepoetin. The data included information on numbers of PRCA cases and estimated exposure-adjusted incidence rates by EPO product, anemia etiology, administration route, country of PRCA identification, and date reported. RESULTS In 1999, academicians in Paris identified 12 EPO-treated patients with antibody-mediated PRCA; 11 of these patients were on hemodialysis and had received subcutaneous Eprex (Johnson & Johnson). In 2002, authorities in Europe, Australia, Singapore, and Canada mandated Eprex by IV route to hemodialysis patients, and the relevant manufacturers added Teflon coating to prefilled syringes of Eprex; PRCA cases subsequently decreased by 90 percent. By 2003, 180 Eprex-associated PRCA cases were identified in Europe, Canada, Australia, and Asia, despite improvements in handling. Since 2002, FDA safety databases include information on 59 new cases of antibody-associated PRCA, primarily associated with subcutaneous epoetin alfa and darbepoetin that does not contain HSA. CONCLUSION Independent actions by regulatory authorities, manufacturers, and academic researchers identified significant numbers of PRCA cases between 1998 and 2003 and characterized the probable etiology. Today, antibody-mediated PRCA is an infrequent class toxicity occurring among some hemodialysis patients on EPOs. PMID:18482185

  14. Analyse de l'efficacité de l'accoutumance à l'eau chez l'enfant préscolaire

    OpenAIRE

    Mornard, Manhattan; Deflandre, Dorian; Delvaux, Anne; Cloes, Marc; Jidovtseff, Boris

    2014-01-01

    L'accoutumance à l'eau apparaît comme un prérequis indispensable à l'apprentissage des techniques de nage. Après différents tests chez des enfants en bas âge, l'étude confirme l'efficacité à l'accoutumance à l'eau. Peer reviewed

  15. Aplasia cutis congenita in a setting of fetus papyraceus associated with small fetal abdominal circumference and high alpha-fetoprotein and amniotic acetylcholinesterase.

    Science.gov (United States)

    Mazza, Joni M; Klein, Janice F; Christopher, Kurt; Silverberg, Nanette B

    2015-01-01

    Fetus papyraceus is the fetal death of one or more fetuses in a multiparous pregnancy. The surviving infants can experience extensive aplasia cutis in an H-shaped distribution over the flanks and abdomen as a consequence of the loss of their fetal sibling. We report the case of a monochorionic, diamniotic pregnancy complicated by a single fetal death at 13 weeks of gestational age. Aplasia cutis of the surviving twin was suggested in utero by three criteria: high amniotic and maternal alpha-fetoprotein, detectable acetylcholinesterase, and small abdominal circumference on prenatal ultrasound. This constellation of findings in the setting of fetus papyraceus can be an indicator of aplasia cutis in the surviving fetus. PMID:24118049

  16. Dapsone-induced pure red cell aplasia and cholestatic jaundice: A new experience for diagnosis and management.

    Science.gov (United States)

    Sawlani, Kamal Kumar; Chaudhary, Shyam Chand; Singh, Jitendra; Raja, Deep Chandh; Mishra, Sanjay; Goel, Madhu Mati

    2016-01-01

    Dapsone (4,4'- diaminodiphenylsulfone) is the parent compound of the sulfones, and it has potent antiparasitic, anti-inflammatory, and immunomodulatory effects. It is used in the treatment of leprosy, dermatitis herpetiformis, and prophylactically to prevent Pneumocystis pneumonia and toxoplasmosis in patients unable to tolerate trimethoprim with sulfamethoxazole. We hereby report a case of dapsone toxicity who developed pure red cell aplasia and cholestatic jaundice in a suspected case of dermatitis herpetiformis. Patient had an excellent response to corticosteroids after withdrawal of dapsone. PMID:27512715

  17. Hematopoiesis stimulation test by interleukin 1α gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation

    International Nuclear Information System (INIS)

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  18. Technologies de l'information - Interconnexion des systèmes ouverts (OSI) - Protocole de service de session en mode sans connexion : spécification du protocole : Amend 1 : amélioration de l'efficacité

    CERN Document Server

    International Organization for Standardization. Geneva

    2000-01-01

    Technologies de l'information - Interconnexion des systèmes ouverts (OSI) - Protocole de service de session en mode sans connexion : spécification du protocole : Amend 1 : amélioration de l'efficacité

  19. Efficacité des moyens de prévention du VIH chez les jeunes de 12 à 20 ans

    OpenAIRE

    Buchmann, Carla; Gilliand, Morgane; Qendresa, Shahini; Ferrandez, Bernard

    2014-01-01

    Introduction : Le sida est actuellement en train d’être banalisé et touche beaucoup de jeunes en Europe. De plus, la prévention actuelle ne répond pas aux besoins des adolescents. Objectif : Cette revue de littérature a pour objectif d’évaluer l’efficacité des programmes de prévention du VIH/sida auprès des jeunes de 12 à 20 ans. Méthode : Les articles ont été obtenus sur Cinahl, PubMed et Google Schoolar, donnant une sélection de huit articles. Résultats : Les principaux résultats démontrent...

  20. Treatment with misonidazole and high voltage irradiation of xenotransplanted human carcinomas in nu/nu mice with thymic aplasia

    International Nuclear Information System (INIS)

    An investigation was conducted in order to determine the effect of combined high voltage irradiation and the sensitizing drug misonidazole (Ro-07-0582) on human gynecologic carcinoma transplanted into nu/nu mice with thymic aplasia. Two carcinomas of the endometrium, two carcinomas of the ovaries, and one carcinoma of the cervix were submitted to Co-60 irradiation with and without misonidazole. The tumor growth was compared to that of control groups. The dosage and fraction of the high voltage irradiation (2 x 5 Gy/week, total dose 60 Gy) were adapted to clinical data. Misonidazole (1 mg/kg body weight) was administered by intraperitoneal injection 15 minutes before the irradiation. Compared with the control animals, the locally irradiated tumors showed a slower growth or even a regression. The administration of misonidazole, however, did not produce significant differences in our five cases. Some reasons for this absence of the radiosensitizing effect of misonidazole are briefly discussed. (orig.)

  1. Aplasia medular após transplante hepático em pediatria Aplastic anemia after pediatric liver transplantation

    Directory of Open Access Journals (Sweden)

    Marlene P. Garanito

    2009-01-01

    Full Text Available A aplasia de medula é uma das mais raras (Aplastic anemia (AA is one of the rarest (<1% and most serious complications of liver transplantation for fulminant non-A, non-B and non-C hepatitis. It was first described in 1987 by Stock; the mechanism involved is an immunologically mediated condition secondary to an unknown viral infection. The disease is associated with a dismal prognosis. Spontaneous recovery from acquired AA is very rare however some patients (50-70% recover after immunosuppressive therapy, such as Cyclosporin A (CsA and Antithymocyte globulin (ATG, even after liver transplantation. Another treatment option is bone marrow transplantation. We report on a child who developed AA following liver transplantation for fulminant viral hepatitis that was treated with intensive immunosuppression including CsA and ATG and achieved complete recovery.

  2. A rare presentation of aplasia cutis congenita after feto-reduction in a trichorionic-triamniotic pregnancy.

    Science.gov (United States)

    Vettori, D J; Jairath, P

    2015-01-01

    Aplasia cutis congenita (ACC) is rare skin disorder of newborns that has been linked to both assisted reproductive technology (ART) and feto-reduction procedures. ACC is characterized by well-demarcated lesions that are devoid of all skin layers. Group-V ACC presents with a distinctive and symmetrical distribution pattern. It is thought to result from an insult to the fetus after concomitant twin demise and is almost exclusively reported in monochorionic gestations.A 41-year-old female with an in vitro fertilization (IVF) assisted tri-chorionic gestation subsequently underwent selective feto-reduction of Fetus C. The patient delivered two pre-term neonates secondary to pre-eclampsia. The initial exam of Twin B showed extensive, well-demarcated, symmetrical areas devoid of any skin over the anterior and lateral trunk, extending up the lateral thoracic walls. Chest and abdominal viscera were visible through a thin fibrous membrane. The skin defects were managed conservatively with twice-daily dressings of Aquaphor, and Vaseline gauze. The areas of aplasia slowly contracted, though residual scarring was noted. After four weeks in the NICU, most of the areas were healed.ACC in multi-fetal pregnancies is a rare, but well-described complication. This is, to our knowledge, the first reported case in a tri-chorionic IVF gestation after feto-reduction. With increased incidence of ART-associated pregnancies and the use of feto-reduction for higher order gestations, this may become more common. Neonates often require specialized intensive care. Conservative management usually will suffice, although surgical grafting may be required. Physicians should be aware of this condition and counsel their feto-reduction patients of the risk. PMID:26485557

  3. Therapeutic potential of ex vivo expansion of haematopoietic precursors for the treatment of accidental irradiation-induced aplasia

    International Nuclear Information System (INIS)

    After whole body overexposure, the key issue is the therapeutic decision, i.e. the choice between bone marrow transplantation and other strategies. The indications of bone marrow transplantation cover only a short range of doses, provided the exposure is distributed uniformly within the body; a rare event in accidental settings. The results of the clinical trials for Granulocyte-Colony Stimulating Factor: G-CSF, Granulocyte/Macrophage Colony Stimulating Factor: GM-CSF or Interleukin 3: IL-3, in vivo and in vitro radiobiology experiments suggest that growth factor therapy could be of use after most accidental overexposures to evidence and to stimulate the remaining haematopoietic stem cells in order to shorten the duration of aplasia, although questions have been raised about growth factor infusion real clinical efficiency. Ex vivo expansion of haematopoietic precursor, stem cells and differentiated cells is a new approach of growth factor therapy, which may be of interest for the treatment of patients with accidental radiation-induced aplasia. These studies aim to expand the pool of progenitors and stem cells for transplantation or to expand differentiated cells (mainly granulocytes but also megakaryocytes) for transfusion. This is made possible due to the development of techniques allowing the selection of a population of haematopoietic progenitors and stem cells from the blood (with stimulation by growth factors prior stem cell harvesting) or bone marrow using immature cell positive selection. The next step consisting in their culture with combination of growth factors or additional stroma cells is also under development. Autologous progenitor cells generated ex vivo has been recently used with some success for reconstitution of haematopoiesis after high-dose chemotherapy. (author)

  4. Etude microdosimetrique de l'influence des materiaux sur l'efficacite biologique d'une source d'iode-125

    Science.gov (United States)

    Taschereau, Richard

    Cette these concerne les implants permanents pour la prostate. Les isotopes employes, le 103Pd et l'125I, semblent produire les memes resultats cliniques: le premier a cause d'une radiation plus efficace et le second a cause de sa demi-vie plus longue. La recherche utilise le cadre theorique de la microdosimetrie et des simulations Monte Carlo. Elle propose d'employer le spectre d'ejection dans le calcul de l'efficacite; ce changement fait passer l'efficacite relative du 103Pd de 10% a 5%. Elle montre ensuite qu'il est possible d'ameliorer l'efficacite de la radiation de 125I par l'exploitation des rayons X caracteristiques de la capsule. Une source amelioree faite de molybdene et d'yttrium est donnee en exemple. Elle procure une radiation de 5--7% plus efficace, ce qui surclasse les deux sources existantes. Les applications ne se limitent pas au traitement de la prostate; le traitement du melanome oculaire et la curietherapie endovasculaire pourraient en beneficier.

  5. Alberto Fujimori : le populisme de l’efficacité

    Directory of Open Access Journals (Sweden)

    Diana Burgos-Vigna

    2005-09-01

    Full Text Available À la tête du Pérou de 1990 à 2000, Alberto Fujimori a su rester populaire en combinant les recettes traditionnelles et nouvelles du populisme. Le discrédit des partis politiques et des syndicats a constitué un contexte favorable à l’arrivée et au maintien au pouvoir de ce non-professionnel de la politique, auquel des valeurs d’honnêteté et de compétence ont été spontanément prêtées. Le chef d’Etat péruvien a construit en outre, tout au long de ses mandats successifs, une stratégie politique destinée à asseoir sa légitimité. Cette stratégie s’est fondée sur des actions telles que : la mise en place d’une relation directe et quasi affective avec les couches les plus défavorisées de la population par le biais de pratiques clientélistes ; la déstructuration du tissu social dans l’objectif d’éviter toute opposition et de renforcer le pouvoir du chef de l’Etat ; l’instrumentalisation de certains groupes d’acteurs, notamment par l’intermédiaire des programmes sociaux ; enfin, le contrôle permanent, et sans cesse renforcé, de l’information, via la surveillance des médias et des opposants. Fondée sur une image d’efficacité, la gestion politique d’Alberto Fujimori est demeurée populaire jusqu’à la fin des années 1990, lorsque la révélation d’affaires de corruption a accéléré la chute de son régime.Presidente de Perú de 1990 a 2000, Alberto Fujimori supo conservar su popularidad mezclando viejas y nuevas recetas del populismo. El descrédito de los partidos políticos y de los sindicatos dibujó el contexto idóneo a la llegada y al mantenimiento al poder de este outsider de la política, al cual muy pronto fueron asociados valores de honestidad y de competencia. El jefe del Estado peruano supo además, a lo largo de sus mandatos sucesivos, construir una estrategia política cuyo objetivo era el asentamiento de su legitimidad. Esta estrategia se fundó principalmente en las

  6. CD19 CAR-targeted T cells induce long-term remission and B Cell Aplasia in an immunocompetent mouse model of B cell acute lymphoblastic leukemia.

    Directory of Open Access Journals (Sweden)

    Marco L Davila

    Full Text Available Although many adults with B cell acute lymphoblastic leukemia (B-ALL are induced into remission, most will relapse, underscoring the dire need for novel therapies for this disease. We developed murine CD19-specific chimeric antigen receptors (CARs and an immunocompetent mouse model of B-ALL that recapitulates the disease at genetic, cellular, and pathologic levels. Mouse T cells transduced with an all-murine CD3ζ/CD28-based CAR that is equivalent to the one being used in our clinical trials, eradicate B-ALL in mice and mediate long-term B cell aplasias. In this model, we find that increasing conditioning chemotherapy increases tumor eradication, B cell aplasia, and CAR-modified T cell persistence. Quantification of recipient B lineage cells allowed us to estimate an in vivo effector to endogenous target ratio for B cell aplasia maintenance. In mice exhibiting a dramatic B cell reduction we identified a small population of progenitor B cells in the bone marrow that may serve as a reservoir for long-term CAR-modified T cell stimulation. Lastly, we determine that infusion of CD8+ CAR-modified T cells alone is sufficient to maintain long-term B cell eradication. The mouse model we report here should prove valuable for investigating CAR-based and other therapies for adult B-ALL.

  7. Clinical importance of digitized chest X-ray for detection of pulmonary infiltrations in bone marrow transplant patients during aplasia

    International Nuclear Information System (INIS)

    Purpose: Evaluation of digitized chest X-ray for the detection of pulmonary infiltrations in bone marrow transplant patients during aplasia. Methods: Digitized chest X-rays of 40 patients (21 female, 19 male) with 'Fever of unknown origin' (FUO) were evaluated concerning radiological signs of pulmonary infiltrations and correlated to clinical findings, blood chemistry, microbiology and bronchoscopy. Additionally, an individual risk profile was established. Results: In 11/40 patients pulmonary infiltrations were detected in digitized chest X-rays (group 1). 10/11 developed an infectious pulmonary infiltration. 29/40 patients developed no pulmonary infiltration (group 2). When fever increased for the first time (initial chest X-ray) a sensitivity, specificity, positive and negative predictive value of 46%, 86%, 56%, 81% and for the chest X-rays in process of 61%, 79%, 68% and 73% was found. C-reactive protein and temperature increase occured statistically significantly earlier (p<0.05) in group 1 compared to group 2. The average latency of digital chest X-rays in comparison to c-reactive protein and temperature increase was 6 days. The incidence of risk factors was significantly higher in group 1 in comparison to group 2 (p<0.05). Conclusion: Digitized chest X-rays are not a reliable method for primary detection of pulmonary infiltrations after bone marrow transplantation. Individual risk factors have to be taken into consideration to indicate further diagnostic methods such as computed tomography at an earlier time. (orig.)

  8. [Changes in bones of the foot and development of inserting tendons of the lower leg musculature in tibial aplasia].

    Science.gov (United States)

    Selke, B; Bogusch, G

    1989-01-01

    Skeleton, muscles and tendons were investigated in 3 lower legs with aplasia of the tibia. The tibiofibular joint appears to be rather a syndesmosis than a diarthrosis. In all 3 cases, talus and calcaneus are connected by a synostosis. Also in the other parts of the skeleton of the feet, synarthroses with different extensions are found. The muscles, normally originating from the tibia, have shifted their origin to the fibula. The proximal part of the inserting tendons under the retinacula is quite normal. Also, their distal part in the region of the metatarsalia and of the digits exhibits no alterations. In the region of the tarsus in which already alterations in bone formation are found, the tendons of the flexor muscles of the toes exhibit some variations. Often the muscles show a new, strong insertion into the bones of the tarsus. The normal connection between the proximal and distal parts of the tendons is sometimes still indicated by a thin bundle of collagenous fibers. In all 3 cases, the tibialis anterior muscle inserts into the distal part of the tendons of the flexor muscles of the toes, indicating that there are also connections between tendons of muscles from different blastemas. PMID:2816255

  9. SELECTION Etude de l’efficacité de la sélection assistée par marqueurs par rapport à la sélection classique

    Directory of Open Access Journals (Sweden)

    Moreau Laurence

    2001-09-01

    Full Text Available Après avoir fait une rapide revue des résultats disponibles à ce jour sur l’utilisation des marqueurs dans les expériences de rétro-croisement, nous nous intéresserons à l’efficacité de la SAM pour la prédiction des valeurs génétiques en nous appuyant notamment sur les résultats préliminaires d’une expérience de SAM en cours à la station de génétique végétale du Moulon.

  10. Communication de changement comportemental sur le Web : comparer l'efficacité de la persuasion et de l'engagement pour promouvoir l'éco-citoyenneté

    OpenAIRE

    Romma, Natacha

    2010-01-01

    À partir de l'interrogation sur le potentiel du Web en tant que nouveau média électronique dans la promotion des comportements éco-responsables, et sur les stratégies de sensibilisation les plus efficaces possibles susceptibles d'être mises en œuvre dans le contexte du Web, ce travail propose de comparer l'efficacité des dispositifs Web persuasif et engageant grâce à la mesure des comportements effectifs des internautes exposés à ce type de dispositifs. Une expérimentation conduite dans une g...

  11. L’appropriation psychologique collective d’un collecticiel: impact sur le fonctionnement interne et l’efficacité des équipes de projet

    OpenAIRE

    Louis Babineau

    2011-01-01

    L’objectif de cette recherche est d’introduire le concept d’appropriation psychologique collective (psychological collective ownership), dans l’étude des déterminants du fonctionnement interne et de l’efficacité des équipes de travail qui utilisent les NTIC pour supporter la réalisation de leur projet. Les résultats montrent qu’un environnement virtuel de travail peut être la cible d’une appropriation psychologique (psychological ownership); que cette appropriation se distingue d’une autre fo...

  12. Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia.

    Science.gov (United States)

    Dao, An T T; Yamazaki, Hirohito; Takamatsu, Hiroyuki; Sugimori, Chiharu; Katagiri, Takamasa; Maruyama, Hiroyuki; Zaimoku, Yoshitaka; Maruyama, Kana; Ly, Trung Q; Espinoza, Luis; Nakao, Shinji

    2016-04-01

    Most patients with acquired pure red cell aplasia (PRCA) and some with acquired aplastic anemia (AA) respond well to cyclosporine (CsA), but thereafter often show CsA dependency. The mechanism underlying this dependency remains unknown. We established a reliable method for measuring the regulatory T cell (Treg) count using FoxP3 and Helios expression as markers and determined the balance between Tregs and other helper T cell subsets in 16 PRCA and 29 AA patients. The ratios of interferon-γ-producing CD4(+) (Th1) T cells to Tregs in untreated patients and CsA-dependent patients were significantly higher (PRCA 5.77 ± 1.47 and 7.38 ± 2.58; AA 6.18 ± 2.35 and 8.94 ± 4.06) than in healthy volunteers (HVs; 3.33 ± 0.90) due to the profound decrease in the percentage of Tregs. In contrast, the ratios were comparable to HVs in convalescent CsA-treated AA patients (4.74 ± 2.10) and AA patients in remission after the cessation of CsA treatment (4.24 ± 1.67). Low-dose CsA (100 ng/ml) inhibited the proliferation of conventional T cells (Tconv) to a similar degree to the inhibition by Tregs in a co-culture with a 1:1 Treg/Tconv ratio. The data suggest that CsA may reverse the hematopoietic suppression in PRCA and AA patients by compensating for the inadequate immune regulatory function that occurs due to a profound decrease in the Treg count. PMID:26968551

  13. Improvement in Erythropoieis-stimulating Agent-induced Pure Red-cell Aplasia by Introduction of Darbepoetin-α When the Anti-erythropoietin Antibody Titer Declines Spontaneously

    OpenAIRE

    Lee, Hajeong; Yang, Jaeseok; Kim, Hyosang; Kwon, Ju Won; Oh, Kook-Hwan; Joo, Kwon Wook; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Kim, Suhnggwon

    2010-01-01

    Anti-erythropoietin antibodies usually cross-react with all kinds of recombinant erythropoietins; therefore, erythropoiesis-stimulating agent (ESA)-induced pure red-cell aplasia (PRCA) is not rescued by different ESAs. Here, we present a case of ESA-induced PRCA in a 36-yr-old woman with chronic kidney disease, whose anemic condition improved following reintroduction of darbepoetin-α. The patient developed progressive, severe anemia after the use of erythropoietin-α. As the anemia did not imp...

  14. Coombs-negative Autoimmune Hemolytic Anemia Followed by Anti-erythropoetin Receptor Antibody-associated Pure Red Cell Aplasia: A Case Report and Review of Literature.

    Science.gov (United States)

    Yoshimi, Mayumi; Kadowaki, Yutaka; Kikuchi, Yuji; Takahashi, Tsuyoshi

    2016-01-01

    A 76-year-old woman was referred to our hospital because of anemia. The laboratory findings revealed hemolysis. Although a direct Coombs test was negative, a high titer of RBC-bound IgG was detected, and a diagnosis of Coombs-negative autoimmune hemolytic anemia was made. She was successfully treated with prednisolone. One year and five months later, she again presented anemia and was diagnosed with pure red cell aplasia. Anti-erythropoietin receptor antibody was detected in the serum. She was treated with cyclosporine and obtained prompt recovery. We herein report this rare case and review the pertinent literature. PMID:26935373

  15. L’évolution des lithométéores en Mauritanie confirme une plus grande efficacité de l’action éolienne

    OpenAIRE

    Nouaceur, Zeineddine

    2001-01-01

    L’étude des lithométéores vise à donner un bilan chiffré de la situation en Mauritanie. L’observation de ces phénomènes atteste d’une tendance à la hausse très nette depuis les années soixante-dix, période à laquelle s’amorçaient les conditions pluviométriques drastiques. Dans la plupart des cas, une liaison étroite associe variabilité pluviométrique et fluctuation des observations des lithométéores. Cette tendance confirme une plus grande efficacité de l’action éolienne sur des substrats pro...

  16. Efficacité énergétique et émissions de GES de systèmes d’élevage bovin viande en Amazonie

    OpenAIRE

    CLERC, Anne-Sophie; Bonaudo, Thierry; Nahum, Benjamim; Dias de Castro, Ronaldo; Poccard-Chapuis, René

    2012-01-01

    L’élevage au Brésil, 1er exportateur mondial de viande, serait responsable de plus de 75% des déforestations et 19% des émissions nationales de gaz à effet de serre (GES). L’objectif de notre étude est de mettre au point une première méthode de calcul d’efficacité énergétique et d’émissions de GES des systèmes d’élevage amazoniens, en se basant sur la méthode Planète. Une révision de l’ensemble des coefficients énergétiques et des facteurs d’émission de GES ainsi que l’ajout de certaines rubr...

  17. Effets de l'adjonction de lipides dans la ration sur les performances de ponte et l'efficacité alimentaire de poules normales ou naines

    OpenAIRE

    Mérat P; Bordas A; El-Attar A

    1986-01-01

    Les performances de ponte et d’efficacité alimentaire ont été comparées pour des poules Leghorn de taille normale (Dw+) ou naines (dw) en présence de 2 régimes à teneurs différentes en lipides totaux. Le régime le plus riche a, dans l’ensemble, un effet négatif sur la variation de poids corporel des pondeuses, du moins pour les poules de taille normale. Pour les poules naines, d’autre part, l’intensité de ponte semble comparativement un peu plus améliorée par le régime enrichi en lipides q...

  18. Gouvernance et efficacité missionnaire de la Compagnie de Jésus : les enseignements d'une théorie élargie de la gouvernance

    OpenAIRE

    Wirtz, Peter

    2013-01-01

    La gouvernance de la Compagnie de Jésus se caractérise dès ses débuts par un certain nombre de particularités, dont le vœu d'obéissance au pape, l'importante autorité du préposé général, ainsi que l'esprit ignatien qui est transmis à travers les exercices spirituels à toutes les générations de jésuites. Dans le présent article, nous montrons que le système particulier de gouvernance de la jeune Compagnie joue un rôle déterminant dans l'efficacité missionnaire de l'ordre, grâce, notamment, à s...

  19. Amelioration de l'efficacite energetique du procede d'electrolyse de l'aluminium conception d'un nouveau bloc cathodique

    Science.gov (United States)

    Blais, Mathieu

    Au Quebec, les alumineries sont de grandes consommatrices d'energie electrique, soit pres de 14 % de la puissance installee d'Hydro-Quebec. Dans ce contexte, des petits gains en efficacite energetique des cuves d'electrolyse pourraient avoir un impact important sur la reduction globale de la consommation d'electricite. Le projet de maitrise decrit dans cette etude repond a la problematique suivante : comment l'optimisation de la geometrie d'un bloc cathodique en vue d'uniformiser la densite de courant peut augmenter l'efficacite energetique et la duree de vie de la cuve d'aluminium? Le but premier du projet est de modifier la geometrie en vue d'ameliorer le comportement thermoelectrique des blocs cathodiques et d'accroitre par le fait meme l'efficacite energetique du procede de production d'aluminium. La mauvaise distribution de la densite de courant dans la cuve est responsable de certains problemes energetiques ayant des impacts negatifs sur l'economie et l'environnement. Cette non-uniformite de la distribution du courant induit une usure prematuree de la surface de la cathode et contribue a reduire la stabilite magnetohydrodynamique de la nappe de metal liquide. Afin de quantifier les impacts que peut avoir l'uniformisation de la densite de courant a travers le bloc cathodique, un modele d'un bloc cathodique d'une cuve de la technologie AP-30 a ete concu et analyse par elements finis. A partir de son comportement thermoelectrique et de donnees experimentales d'une cuve AP-30 tirees de la litterature, une correlation entre le profil de densite de courant a la surface du bloc et le taux d'erosion local au meme endroit a ete creee. Cette relation correspond au modele predictif de la duree de vie de tout bloc du meme materiau a partir de son profil de densite de courant. Ensuite, une programmation a ete faite incorporant dans une meme fonction cout les impacts economiques de la duree de vie, de la chute de voltage cathodique et de l'utilisation de nouveaux materiaux

  20. Construire la confiance des subordonnés : le rôle du contexte dans l’efficacité du leadership

    OpenAIRE

    Abid-Dupont, Marie-Aude; Chandon, Jean-Louis

    2013-01-01

    Cette recherche identifie les leviers managériaux de production de confiance en fonction du contexte. Une première étude exploratoire révèle deux stratégies de développement de la confiance, l’échange de ressources et l’appartenance à un collectif de travail. Le pouvoir formel du supérieur conditionne l’efficacité de ces deux stratégies de construction de la confiance. Sur un échantillon d’anciens diplômés de grandes écoles d’ingénieurs françaises, les résultats montrent qu’un supérieur dispo...

  1. Evaluation de l'efficacité d'un entraînement métacognitif chez des adolescents souffrant de psychose

    OpenAIRE

    Orcel S.

    2011-01-01

    Contexte :¦La formation et le maintien d'idées délirantes et des hallucinations, qui sont des symptômes clé de la psychose, s'expliquent en partie par la présence de biais cognitifs. La faisabilité, l'adhérence au traitement, l'utilité subjective et également l'efficacité d'un entraînement métacognitif (EMC) permettant de corriger ces biais cognitifs ont été démontrées chez des adultes schizophrènes. Par contre, aucune étude ne s'est intéressée à ces aspects dans une population adolescente at...

  2. Évaluation expérimentale de l'efficacité d'un candidat vaccin sous-unitaire contre le virus respiratoire syncytial bovin

    OpenAIRE

    Soulestin , Marion

    2009-01-01

    Une étude récente a démontré qu’un candidat vaccin sous unitaire composé d’anneaux formés par la nucléoprotéine recombinante du virus respiratoire syncytial humain (nanoparticules N-SRS) pouvait protéger des souris contre une inoculation d’épreuve (Roux et al., 2008). L’objectif de ce projet était d’évaluer l’efficacité de ce vaccin chez le veau, espèce cible naturelle du virus respiratoire syncytial bovin. Pour cela, 24 veaux séronégatifs vis-à-vis du virus et indemnes d’infectio...

  3. CONTRIBUTION A L’ETUDE THEORIQUE DE L’EFFICACITE DU BLINDAGE ELECTROMAGNETIQUE EN CHAMP PROCHE CAS DES POLYMERES CONDUCTEURS COMPOSITES

    OpenAIRE

    MIDOUD, Nouria

    2011-01-01

    Ce travail, est une contribution à l’étude théorique de l’efficacité du blindage électromagnétique à base de polymères conducteurs composites en champ proche. Dans ce cadre, nous réalisons une étude comparative entre les blindages obtenus à l’aide de matériaux classiques tels que l’aluminium, le zinc, le trioxyde de vanadium et, ceux réalisée par les polymères conducteurs composites renforcés par ces mêmes matériaux à l’instar du nylon6/aluminium, nylon6/zinc, polyéthylène haute d...

  4. Metabolism of {sup 137}cesium, {sup 137}barium in the rat. Therapeutics of the contamination; Metabolisme du {sup 137}cesium, {sup 137}baryum chez le rat. Therapeutique de la contamination

    Energy Technology Data Exchange (ETDEWEB)

    Remy, J.; Philippon, A.; Lafuma, J.; Walter, C. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Departement de la Protection Sanitaire, Laboratoire de Radiopathologie

    1967-07-01

    'elimination du {sup 137}Cs - {sup 137}Ba chez le rat. Ils montrent l'independance de ces phenomenes vis-a-vis des modalites d'une administration unique. La distribution tend dans tous les cas vers un schema type qui se maintient ensuite identique a lui-meme en fonction de la charge corporelle. L'analyse biochimique de l'etat du cesium dans les milieux biologiques montre qu'il y est transporte sous une forme libre et ionisee. Abordant le probleme du mode de penetration de l'ion cesium dans le milieu intracellulaire et notamment par l'etude cinetique du systeme plasma-hematie in vivo et in vitro, les auteurs adoptent l'hypothese d'un transport actif du cesium par la membrane cellulaire. Ils en arrivent ainsi a un schema general de la distribution du cesium dans l'organisme, essentiellement caracterise par un equilibre dynamique de repartition entre deux compartiments: 99 pour cent du cesium est accumule dans le pool intracellulaire, 1 pour cent dans les liquides extracellulaires. Ce dernier compartiment est ouvert sur les emonctoires. Du fait du transport actif par les membranes cellulaires, la charge du pool intracellulaire est rapide, mais la decharge est lente. Ce phenomene est le facteur limitant de la decroissance de la charge corporelle. De ce schema les auteurs deduisent les raisons de l'echec relatif des diverses voies therapeutiques explorees a ce jour par eux-memes, et par d'autres auteurs. La stimulation des emonctoires naturels, dans le cas des diuretiques par exemple, ne saurait accroitre que l'epuration du compartiment extracellulaire. Or ce dernier ne contient que 1 pour cent de la charge corporelle et sa recharge est lente. En outre, les procedes visant a contrarier ou inhiber le transport actif du cesium par la membrane cellulaire restent, a ce jour, incompatibles avec la survie de la cellule. (auteurs)

  5. Energy efficiency; Efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2006-06-15

    This road-map proposes by the Group Total aims to inform the public on the energy efficiency. It presents the energy efficiency and intensity around the world with a particular focus on Europe, the energy efficiency in industry and Total commitment. (A.L.B.)

  6. New method for studying the efficiency of chelating agents of the polyamine acid series for internal decontamination; Methode nouvelle d'etude de l'efficacite des chelateurs de la serie des acides polyamines pour la decontamination interne

    Energy Technology Data Exchange (ETDEWEB)

    Lafuma, J.; Nenot, J.C.; Morin, M. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    We followed the biological fate of a complex formed on one side with either a rare earth (cerium-144) or a transuranium element (plutonium-239), and on the other side with a chelating agent of the polyamino acid series (EDTA, BAETA, DTPA, TTHA). This method allowed to study: 1 - the in vivo stability of the various complexes and to compare them; 2 - the stability of the complexes as a function of the isotope - chelating agent weight relationships; 3 - the metabolism of the chelating agents resulting in stable complexes, i. e. DTPA and TTHA mainly. This simple method brought out the higher efficiency, of DTPA in chelating rare earths and plutonium and for therapeutic purposes. (authors) [French] La methode consiste a suivre le devenir biologique d'un complexe forme d'une part avec une terre rare (cerium 144) ou un transuranien (plutonium 239) et d'autre part avec un chelateur de la serie des acides polyamines (EDTA, BAETA, DTPA, TTHA). Elle permet d'etudier: 1 - la stabilite in vivo des differents complexes, de les comparer; 2 - la stabilite des complexes en fonction des rapports ponderaux isotope - chelateurs; 3 - le metabolisme des chelateurs formant des complexes stables, essentiellement DTPA et TTHA. Cette methode simple degage la suprematie du DTPA en ce qui concerne la chelation des terres rares et du plutonium, et son utilisation a des fins therapeutiques. (auteurs)

  7. Efficacité technique des unités de production informelles: une approche de régressions quantiles. Le cas de l'agglomération d'Antananarivo

    OpenAIRE

    Faly Henry Rakotomanana

    2010-01-01

    Cette étude a pour objet d’analyser le degré l’efficacité technique des unités de production informelles et ses déterminants dans le cas de l’agglomération d’Antananarivo à Madagascar en utilisant les bases de données issues d’une série d’enquête de type 1-2-3 sur le secteur informel réalisées en 2001 et 2004. La méthode de la régression par quantile est retenue dans les modèles pour tenir compte des fortes disparités des unités en termes de performances. Le degré d’efficacité des unités de p...

  8. Analyse de l'activité et développement de l'auto-efficacité : Un levier pour la professionnalisation des étudiants en sciences infirmières au Liban

    OpenAIRE

    Khawand Ayle, Ghada; Nagels, Marc

    2014-01-01

    Dans le cadre de la réingénierie de la formation infirmière dans une université au Liban, l’étude montre que l’analyse de l’activité est un facteur de développement de l’auto-efficacité pour la conception d’un projet de soins chez les étudiants. L'auto-efficacité d’un individu se présente essentiellement comme une évaluation personnelle de sa compétence pour agir dans une classe de situations donnée. Ce sentiment de compétence perçue par le professionnel ou l’étudiant est une variable détermi...

  9. Quelle est l'efficacité et l'innocuité de l'utilisation de l'homéopathie en période périnatale ?: travail de Bachelor

    OpenAIRE

    Progin, Delphine; Hernandez, Marion; Nunno, Catia

    2013-01-01

    Ce travail a pour objectif d’évaluer l’efficacité et l’innocuité de l’homéopathie utilisée pendant la période périnatale, pour pouvoir permettre aux professionnels de la santé et plus particulièrement aux sages-femmes de conseiller et diriger avec plus de certitudes leurs patientes, qui en sont de grandes utilisatrices.

  10. Linking Drugs to Obscure Illnesses: Lessons from Pure Red Cell Aplasia, Nephrogenic Systemic Fibrosis, and Reye’s Syndrome. A Report From the Southern Network on Adverse Reactions (SONAR)

    OpenAIRE

    Bennett, Charles L.; Starko, Karen M.; Thomsen, Henrik S; Cowper, Shawn; Sartor, Oliver; Macdougall, Iain C.; Qureshi, Zaina P; Bookstaver, P. Brandon; Miller, April D; Norris, LeAnn B.; Xirasagar, Sudha; Trenery, Alyssa; Lopez, Isaac; Kahn, Adam; Murday, Alanna

    2012-01-01

    Identification of serious adverse drug reactions (sADRS) associated with commonly used drugs can elude detection for years. Reye’s syndrome (RS), nephrogenic systemic fibrosis (NSF), and pure red cell aplasia (PRCA) among chronic kidney disease (CKD) patients were recognized in 1951, 2000, and 1998, respectively. Reports associating these syndromes with aspirin, gadodiamide, and epoetin, were published 29, 6, and 4 years later, respectively. We obtained primary information from clinicians who...

  11. Cryogénie hélium et efficacité énergétique: L'expérience du LHC au CERN

    CERN Document Server

    Claudet, S; Tavian, L

    2012-01-01

    Résumé La supraconductivité et la cryogénie hélium associée sont devenues des technologies clés des grands équipements de recherche en physique, et en particulier des accélérateurs de particules. Le coût thermodynamique du fonctionnement à basse température impose à leurs systèmes cryogéniques une haute efficacité énergétique dans la gestion des charges thermiques, la distribution des fluides et la production de froid, obtenue par une approche intégrée couvrant toutes les phases du projet, de la conception préliminaire jusqu'à l'exploitation. L'expérience du LHC au CERN vient illustrer le propos, tandis que quelques pistes de développements futurs sont évoquées. Abstract Superconductivity and associated helium cryogenics have become key technologies for large research infrastructures in physics, and particularly particle accelerators. The thermodynamic penalty for operating at low temperature requires their cryogenic systems to be highly energy efficient in managing heat loads, dis...

  12. Analysis of the energy efficiency of the transport system in Algeria; Analyse de l'efficacite energetique du systeme de transport en Algerie

    Energy Technology Data Exchange (ETDEWEB)

    Hamdani, Sid Ahmed

    2010-09-15

    The objective of this communication is analyze the energy efficiency of the transport system in Algeria and to show the areas of possible rationalization in this sector. Our approach is to analyze the existing configuration of the sector and its impact on energy consumption, by developing a sectional model Bottom Up, where the transport park has been modified by the means used. We have shown that the potential to improve the transport system energy efficiency is important and have recommended some options aimed at the sector organisation and aimed at increasing the relative part of transport systems to make it more energy efficient. [French] L'objectif de cette communication est d'analyser l'efficacite energetique du systeme de transport algerien et de montrer les gisements de rationalisation possibles dans ce secteur. Notre approche consiste a analyser la configuration existante du secteur et son impact sur la consommation d'energie, en elaborant un modele sectoriel Bottom Up, ou le parc de transport a ete desagrege par moyen utilise. Nous avons montre que le potentiel d'amelioration de la performance energetique du systeme de transport est important et avons recommande quelques options ciblant l'organisation du secteur et visant a augmenter la part relative de moyens de transport plus efficace energetiquement.

  13. Pure red cell aplasia due to parvovirus B19 infection after liver transplantation: A case report and review of the literature

    Institute of Scientific and Technical Information of China (English)

    Ting-Bo Liang; Shu-Sen Zheng; Dong-Lin Li; Jun Yu; Xue-Li Bai; Liang Liang; Shi-Guo Xu; Wei-Lin Wang; Yan Shen; Min Zhang

    2007-01-01

    Pure red cell aplasia (PRCA) due to parvovirus B19(PVB19) infection after solid organ transplantation has been rarely reported and most of the cases were renal transplant recipients. Few have been described after liver transplantation. Moreover, little information on the management of this easily recurring disease is available at present. We describe the first case of a Chinese liver transplant recipient with PVB19-induced PRCA during immunosuppressive therapy. The patient suffered from progressive anemia with the lowest hemoglobin level of 21 g/L. Bone marrow biopsy showed selectively inhibited erythropoiesis with giant pronormoblasts. Detection of PVB19-DNA in serum with quantitative polymerase chain reaction (PCR) revealed a high level of viral load.After 2 courses of intravenous immunoglobulin (IVIG)therapy, bone marrow erythropoiesis recovered with his hemoglobin level increased to 123 g/L. He had a lowlevel PVB19 load for a 5-mo follow-up period without recurrence of PRCA, and finally the virus was cleared.Our case indicates that clearance of PVB19 by IVIG in transplant recipients might be delayed after recovery of anemia.

  14. Étude de l’efficacité de différentes souches de trichogrammes vis-à-vis de Tuta absoluta (Meyrick) en serres expérimentales

    OpenAIRE

    Legendre, Gaspar; Buradino, Maurane; Trottin, Yannie; Leyre, Jean-Michel; Baffert, Véronique; Colombel, Etty; Tabone, Elisabeth

    2014-01-01

    Le ravageur invasif de la tomate, Tuta absoluta, continue son expansion dans le bassin méditerranéen et entraîne des dégâts importants sur les cultures. Les méthodes de lutte biologique mises en place actuellement impliquent l’utilisation de l’auxiliaire exotique Trichogramma achaeae. La production de ce parasitoïde oophage est onéreuse. Des souches autochtones de trichogrammes ayant une efficacité comparable vis-à-vis de T. absoluta mais moins couteux à produire ont été recherchés. Des souch...

  15. Relation entre l’agressivité des souches de B. cinerea et l’efficacité de la protection biologique conférée par deux agents de lutte biologique

    OpenAIRE

    Comby, Morgane

    2011-01-01

    Les méthodes de lutte actuelles contre l’agent responsable de la pourriture grise, Botrytis cinerea, ne suffisent pas à garantir une protection totale contre ce champignon pathogène, capable de développer des résistances à de nombreux fongicides. Dans ce contexte, la protection biologique semble prometteuse mais la durabilité de cette méthode de lutte a été très peu étudiée. La perte d’efficacité des agents de lutte biologique pourrait résulter de la préexistence d’isolats moins sensibles de ...

  16. Hematopoiesis stimulation test by interleukin 1{alpha} gene transfer in the Cynomolgus macaque: application to secondary medullary aplasia from an accidental irradiation; Essais de stimulation de l'hematopoiese par le transfert de gene de l'interleukine-1{alpha} chez le macaque cynomolgus: application a l'aplasie medullaire secondaire a une irradiation accidentelle

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, Th.

    2002-12-15

    After a description of the context of medullary aplasia (haematological radiobiology, radiation acute syndrome, therapeutic care), and an overview of knowledge about the interleukin-1 and medullary stroma cells, this research thesis aims at investigating therapeutic alternatives for radio-accidental aplasia. More precisely, it aims at defining means to get cytokines which are efficient for haematopoiesis. Interleukin-1 is chosen for its properties and tests are performed on a macaque with two approaches for gene transfer: an ex vivo transfer by retroviral vector enabling an integration in the target cell genome, and an in situ transfer by adeno-viral vector directly applied in the animal osseous medulla

  17. Le Sentiment d’Efficacité Professionnelle, un indicateur pour connaître le développement professionnel des « nouveaux » professeurs de l’enseignement agricole français

    OpenAIRE

    Jean-François Marcel

    2011-01-01

    Cet article est structuré autour d’un indicateur visant à appréhender le développement professionnel dans une perspective heuristique. Il s’agit du Sentiment d’Efficacité Professionnelle emprunté à Bandura (2003). Cet indicateur se positionne le long d’un continuum allant de la théorie à l’empirie et en assume la cohérence et la consistance. Ainsi, il s’ancre dans un cadre théorique (le développement professionnel perçu) et, au travers d’un dispositif méthodologique, permet d’accéder à l’empi...

  18. Castration du porcelet : évaluation de l'efficacité analgésique per-opératoire de l'huile essentielle Mentha arvensis (menthe des champs) par l'analyse des vocalisations

    OpenAIRE

    Zbik, Marion

    2013-01-01

    La castration des porcelets mâles est légalement pratiquée avant l'âge de 7 jours sans analgésie ni anesthésie, Cette castration chirurgicale cause une douleur importante aux porcelets. Dans un contexte où le bien-être animal a une place importante, et où l'engouement pour les "médecines alternatives" prend de l'ampleur, l'objet de notre projet est d'évaluer l'efficacité analgésique de l'huile essentielle de menthe des champs en application topique avant la castration, L'outil choisi pour éva...

  19. Efficacité de l'association des céréales et du niébé pour la production de grains et la lutte contre Striga hermonthica (Del.)

    OpenAIRE

    Lawane, Gilbert; Sougnabé, Souapibé Pabamé; Lendzemo, Vénasius; Gnokreo, F.; Djimasbeye, N.; Ndoutamia, G.

    2009-01-01

    Les cultures faux-hôtes du striga et la limitation de la dissémination des graines de striga constituent les principales préoccupations de la recherche ces dernières années. La rotation et l'association des cultures céréalières avec des cultures faux-hôtes du striga diminuent dans une forte proportion le stock des graines de Striga hermonthica dans le sol, améliore la fertilité du sol, donc augmente leur rendement. L'objectif de cette étude est d'évaluer l'efficacité des cultures faux-hôtes d...

  20. Élaboration et validation de l’échelle de la perception et du sentiment d’auto-efficacité en vidéocommunication (ÉPAV)

    OpenAIRE

    Lise Lachance; Patrick Giroux

    2008-01-01

    [Français] L’article présente le processus d’élaboration et de validation de l’échelle de la perception et du sentiment d’auto-efficacité des apprenants vis-à-vis de la vidéocommunication (ÉPAV). Basée sur la théorie sociocognitive de Bandura (1977, 1982, 1997/2007), cette échelle permet d’évaluer deux dimensions : la perception générale de la vidéocommunication et celle que l’individu a de son propre niveau de compétence dans ce contexte. Les résultats soutiennent la structure bidimensionnel...

  1. Efficacité de l’endossement par les célébrité en publicité : Rôle médiateur de la congruence avec l’image de soi

    OpenAIRE

    Jaoued-Abassi, Leyla; Chandon, Jean-Louis

    2006-01-01

    Cet article montre que les caractéristiques de la célébrité (crédibilité et congruence avec la marque) influencent l’efficacité de l’endossement. Il met également en avant le rôle médiateur de la congruence avec l’image de soi ainsi que le rôle modérateur de l’implication dans la catégorie de produit, le contexte de consommation du produit et l’attitude envers la marque antérieure à l’exposition. Les variables dépendantes du modèle sont l’attitude envers l’annonce, l’attitude envers la marque...

  2. Variabilité génétique de l'efficacité alimentaire en régime alimentaire suboptimal chez le poulet de chair : perspectives pour la sélection

    OpenAIRE

    Mignon-Grasteau, Sandrine; Narcy, Agnès; Tran, Thanh-Son; de Verdal, Hugues; Bastianelli, Denis; Juin, Herve; Carré, Bernard

    2013-01-01

    Le coût de l’aliment représente une part prépondérante des coûts de production du poulet de chair. L’efficacité alimentaire est donc un élément clé de la rentabilité de la production avicole. La sélection génétique des poulets de chair a résulté en une amélioration considérable de l’indice de consommation, en utilisant des régimes alimentaires de bonne qualité. De nos jours, alors que le prix des matières premières de bonne qualité et que la population humaine augmentent, l’intérêt d’une séle...

  3. Evaluation à échelle réduite de l'efficacité d'insecticides régulateurs de croissance sur les larves du complexe Simulium damnosum (Diptera : Simuliidae)

    OpenAIRE

    Doannio, J.M.C.; Dossou-Yovo, J.; Duval, Jacques; Hougard, Jean-Marc

    1992-01-01

    L'efficacité de formulations de régulateurs de croissance des insectes a été testée à échelle réduite sur des larves du complexe #Simulium damnosum$ en Côte d'Ivoire. Trois des composés testés appartiennent au groupe des benzoyphényl-urée substitués, inhibiteurs de synthèse de la chitine (OMS 2015 (triflumuron), OMS 3009 (téflubenzuron), OMS 3013 (chlorfluazuron)). Deux autres appartiennent au groupe des analogues synthétiques de l'hormone juvénile (OMS 3007 et OMS 3019). Le dernier est un ph...

  4. L'efficacité d'usage énergétique : pour une meilleure gestion de l'énergie électrique intégrant l'usager dans les bâtiments

    OpenAIRE

    Chenailler, Hervé

    2012-01-01

    La consommation énergétique, et en particulier électrique, des bâtiments est grandement influencée par le comportement de ses usagers. L'analyse de l'usage électrique au travers d'un retour d'expérience réalisé sur une plateforme bâtiment-test nous a permis d'identifier qu'il pouvait exister différentes formes de satisfactions des usagers remettant en question la notion même d'efficacité énergétique d'un bâtiment. Afin de pouvoir intégrer l'acteur humain dans la conception de systèmes complex...

  5. L'efficacité d'usage énergétique : pour une meilleure gestion de l'énergie électrique intégrant les occupants dans les bâtiments

    OpenAIRE

    Chenailler, Hervé

    2012-01-01

    La consommation énergétique, et en particulier électrique, des bâtiments est grandement influencée par le comportement de ses usagers. L'analyse de l'usage électrique au travers d'un retour d'expérience réalisé sur une plateforme bâtiment-test nous a permis d'identifier qu'il pouvait exister différentes formes de satisfactions des usagers remettant en question la notion même d'efficacité énergétique d'un bâtiment. Afin de pouvoir intégrer l'acteur humain dans la conception de systèmes complex...

  6. Influence de la fréquence et de la période de nourrissage sur la croissance et l'efficacité alimentaire d'un silure africain, Heterobranchus longifilis (Teleostei, Clariidae)

    OpenAIRE

    Kerdchuen, N.; Legendre, Marc

    1991-01-01

    L'influence de la période (jour, nuit) et de la fréquence d'alimentation (1 à 4 repas fractionnés ou alimentation continue) a été étudiée sur la croissance et l'efficacité alimentaire chez un silure africain (#Heterobranchus longifilis$). L'expérience, d'une durée de 56 jours, a été réalisée sur des poissons de 74 g de poids moyen initial. Avec un même taux de rationnement (3% du poids moyen vif/jour), les poissons nourris la nuit ont une croissance significativement plus élevée que ceux nour...

  7. Aspergillosis in immunocompromised children acute myeloid leukemia and bone marrow aplasia.: Report of two cases Aspergilose em crianças imunocomprometidas com leucemia mielóide aguda e aplasta de medula óssea: Registro de 2 casos

    Directory of Open Access Journals (Sweden)

    Maria Zilda de Aquino

    1994-10-01

    Full Text Available Two cases of Aspergillosis in immunocompromised children are reported. Both were caused by Aspergillns flavus. Early diagnosis and treatment led to the remission of the process. One patient had acute myeloid leukemia; the fungus was isolated from the blood. The other patient with bone marrow aplasia, presented an invasive aspergillosis of the paranasal sinuses with dissemination of fungal infection; the diagnosis was obtained by histology and culture of biopsied tissue from a palatal ulceration.No presente trabalho são registrados dois casos de aspergilose em crianças imunocomprometidas. O estudo micológico completo identificou Aspergillus flavus como agente dos dois processos. A presença cada vez mais frequente da aspergilose invasiva deve-se ao número crescente de pacientes imunocomprometidos, muitos com hemopatias graves submetidos à quimioterapia. O diagnóstico precoce em um dos casos possibilitou remissão do processo. Tratava-se de paciente com leucemia mielóide aguda, tendo sido isolado o fungo do sangue circulante. O segundo caso evoluiu para óbito, com infecção fúngica generalizada.

  8. Long-term outcome of individuals with pure red cell aplasia and antierythropoietin antibodies in patients treated with recombinant epoetin: a follow-up report from the Research on Adverse Drug Events and Reports (RADAR) Project

    Science.gov (United States)

    Bennett, Charles L.; Cournoyer, Denis; Carson, Kenneth R.; Rossert, Jerome; Luminari, Stefano; Evens, Andrew M.; Locatelli, Francesco; Belknap, Steven M.; McKoy, June M.; Lyons, E. Alison; Kim, Benjamin; Sharma, Rishi; Costello, Stacey; Toffelmire, Edwin B.; Wells, George A.; Messner, Hans A.; Yarnold, Paul R.; Trifilio, Steven M.; Raisch, Dennis W.; Kuzel, Timothy M.; Nissenson, Allen; Lim, Lay-Cheng; Tallman, Martin S.; Casadevall, Nicole

    2005-01-01

    Since its introduction in 1988, recombinant human erythropoietin (epoetin) has been standard treatment for patients with anemia due to chronic kidney disease. From 1998 to 2004, nearly 200 epoetin-treated persons with chronic kidney disease developed antibodies to epoetin, resulting in pure red cell aplasia (PRCA). The majority of these patients received Eprex, an epoetin alfa product marketed exclusively outside the United States. Herein, we report on the long-term outcome of these individuals. For 170 chronic kidney disease patients who developed epoetin-associated PRCA and had 3 months or more follow-up information available, case reports from the Food and Drug Administration and epoetin manufacturers were reviewed for information on clinical characteristics of the patients, immunosuppressive treatments, epoetin responsiveness, and hematologic recovery. Overall, 64% of the PRCA patients received immunosuppressive therapy, including 19 who also underwent a renal transplantation. Thirty-seven percent experienced a hematologic recovery, with higher hematologic recovery rates among PRCA patients who received immunosuppressive therapy (57% vs 2%, P < .001). Among 34 patients who received epoetin after the onset of PRCA, 56% regained epoetin responsiveness. The highest rates of epoetin responsiveness were observed among persons whose antierythropoietin antibodies were undetectable when epoetin was administered (89%). Among chronic kidney disease patients with epoetin-associated PRCA, epoetin discontinuation and immunosuppressive therapy or renal transplantation is necessary for hematologic recovery. Reinitiation of epoetin therapy among individuals could be considered if antierythropoietin antibodies are undetectable. PMID:16099877

  9. Efficacité d'un exutoire de dévalaison et d'une barrière acoustique pour les smolts de saumon atlantique (Salmo salar L. à l'aménagement hydroélectrique de St. Cricq sur le gave d'Ossau.

    Directory of Open Access Journals (Sweden)

    TRAVADE F.

    1999-04-01

    Full Text Available Une expérimentation a été conduite en 1996 au niveau de l'aménagement hydroélectrique de St. Cricq (gave d'Ossau dans le but de tester deux dispositifs de dévalaison destinés à éviter le passage dans les turbines des smolts de saumon atlantique (Salmo sala L.. Le premier, localisé au barrage, consiste en une barrière acoustique répulsive destinée à détourner les smolts vers un clapet de décharge. Le champ sonore, généré par 16 émetteurs immergés, est dans la gamme de fréquence 100-600 Hz avec un niveau sonore maximal de 120-130 dB. Le deuxième dispositif, localisé à l'usine, consiste en un exutoire de surface situé en rive, à proximité immédiate de la grille de prise d'eau. L'efficacité des deux dispositifs a été évaluée par marquage-recapture et le comportement des smolts a été suivi par radiotélémétrie. Les passages de smolts par le clapet du barrage varient de 20 % à 60 % ; cette efficacité résulte essentiellement du débit élevé transitant par le clapet. Les tests effectués avec et sans barrière acoustique n'ont mis en évidence aucun effet significatif du champ sonore. L'efficacité de l'exutoire du bassin de mise en charge est d'environ 80 %. La faible largeur de la prise d'eau (11 m, le faible espacement des barreaux de la grille de prise d'eau (2,5 cm, les conditions hydrauliques devant la grille qui guident rapidement les poissons vers l'entrée de l'exutoire, et la configuration de l'entrée de l'exutoire qui crée un écoulement à faible gradient de vitesse peuvent expliquer l'efficacité élevée de ce dispositif.

  10. Le Sentiment d’Efficacité Professionnelle, un indicateur pour connaître le développement professionnel des « nouveaux » professeurs de l’enseignement agricole français

    Directory of Open Access Journals (Sweden)

    Jean-François Marcel

    2011-06-01

    Full Text Available Cet article est structuré autour d’un indicateur visant à appréhender le développement professionnel dans une perspective heuristique. Il s’agit du Sentiment d’Efficacité Professionnelle emprunté à Bandura (2003. Cet indicateur se positionne le long d’un continuum allant de la théorie à l’empirie et en assume la cohérence et la consistance. Ainsi, il s’ancre dans un cadre théorique (le développement professionnel perçu et, au travers d’un dispositif méthodologique, permet d’accéder à l’empirie. L’enquête par questionnaire est conduite auprès d’une population de nouveaux professeurs de l’enseignement agricole français. Elle permet de mettre au jour un panorama du développement professionnel perçu par ces enseignants, d’alimenter une analyse critique de l’indicateur proposé et de dresser quelques perspectives pour les recherches à venir.The article is based on an indicator aiming at understanding teachers’ professional development in a heuristic perspective: professional self efficacy borrowed from Bandura (2003. This indicator is situated in a continuum going from theory to empirical data and maintains both its consistency and substance. It is thus, part of a theoretical framework (perceived professional development and permits, through a methodological process, to reach empirical elements. A survey by questionnaire was carried out among new teachers of French agricultural education. The study brings to light an overview of the professional development perceived by these teachers, it permits to build a critical analysis of the indicator in question and draw up new prospects for future research.

  11. Measure of the efficiency of a long counter of Hanson's type and use of this counter for the survey of the slow neutrons coming from the reactor of Chatillon; Mesure de l'efficacite d'un long compteur du type Hanson et utilisation de ce compteur a l'etude des neutrons lents sortant de la pile de Chatillon

    Energy Technology Data Exchange (ETDEWEB)

    Barloutaud, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1953-07-01

    A detection device of fast neutrons of efficiency almost independent of the energy of the neutrons has been achieved. It efficiency has been measured in absolute value for groups of neutrons of different energies. This device allowed to get some indications on the energy composition of the neutrons leaving from the reactor of Chatillon. (author) [French] Un dispositif de detection de neutrons rapides d'efficacite pratiquement independante de l'energie des neutrons a ete realise. Son efficacite a ete mesuree en valeur absolue pour des groupes de neutrons de diverses energies. Ce dispositif a permis obtenir quelques indications sur la composition energetique des neutrons sortant de la pile de Chatillon. (auteur)

  12. One-Dimensional Modelling of Polymer Flood Performance. Analytical and Graphical Solutions Modélisation de l'efficacité du déplacement unidimensionnel par injection de polymères. Solutions analytiques et graphiques

    Directory of Open Access Journals (Sweden)

    Grattoni C. A.

    2006-11-01

    Full Text Available A graphical method for simulating linear polymer flooding is proposed. The method is based upon the analytical solution of Darcy's law and continuity equation which describe the two-phase, one-dimensional, incompressible flow of oil and polymer solution through the reservoir rock. Continuous polymer injection and polymer slug injection are considered. Several physical mechanisms determining microscopic displacement efficiency are taken into account: resistance factor, residual resistance factor, retention composed by adsorption and mechanical entrapment, and inaccessible pore volume. Other properties are not considered: mixing and dispersion, shear and thermal degradation. This analytical-graphical model closely reproduces linear laboratory oil displacement experiments. Consequently, it can be used by the Field Engineer to rapidly estimate the additional oil recoverable by a linear polymer flood. On propose dans cet article une méthode graphique de simulation de l'injection de polymères dans le cas unidimensionnel. Cette méthode est basée sur la solution analytique de la loi de Darcy et de l'équation de continuité qui décrivent l'écoulement diphasique incompressible unidimen-sionnel d'huile et d'une solution de polymères à travers la roche réservoir. On examine l'injection continue et l'injection de bouchons de polymères. On prend en compte plusieurs mécanismes physiques qui déterminent l'efficacité du déplacement microscopique : facteur de ré-sistance, facteur de résistance résiduel, rétention due à l'adsorption et au piégeage mécanique et, enfin, volume des pores inacessibles. On ne tient pas compte des autres propriétés : mélange et dispersion, dégradation mécanique et thermique. Ce modèle analytique et graphique reproduit très directement les expériences de laboratoire de déplacement d'huile en milieu unidimensionnel. II peut donc être utilisé par l'ingénieur de chantier pour une estimation rapide de l

  13. Clinical importance of digitized chest X-ray for detection of pulmonary infiltrations in bone marrow transplant patients during aplasia; Wertigkeit der digitalen Thoraxaufnahme bei der Detektion von Lungeninfiltraten knochenmarktransplantierten Patienten in der Aplasie

    Energy Technology Data Exchange (ETDEWEB)

    Weber, C.; Maas, R.; Steiner, P.; Kramer, J.; Bumann, D.; Buecheler, E. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Abt. fuer Roentgendiagnostik; Zander, A.R. [Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Zentrum fuer Knochenmarktransplantation

    1999-10-01

    Purpose: Evaluation of digitized chest X-ray for the detection of pulmonary infiltrations in bone marrow transplant patients during aplasia. Methods: Digitized chest X-rays of 40 patients (21 female, 19 male) with 'Fever of unknown origin' (FUO) were evaluated concerning radiological signs of pulmonary infiltrations and correlated to clinical findings, blood chemistry, microbiology and bronchoscopy. Additionally, an individual risk profile was established. Results: In 11/40 patients pulmonary infiltrations were detected in digitized chest X-rays (group 1). 10/11 developed an infectious pulmonary infiltration. 29/40 patients developed no pulmonary infiltration (group 2). When fever increased for the first time (initial chest X-ray) a sensitivity, specificity, positive and negative predictive value of 46%, 86%, 56%, 81% and for the chest X-rays in process of 61%, 79%, 68% and 73% was found. C-reactive protein and temperature increase occured statistically significantly earlier (p<0.05) in group 1 compared to group 2. The average latency of digital chest X-rays in comparison to c-reactive protein and temperature increase was 6 days. The incidence of risk factors was significantly higher in group 1 in comparison to group 2 (p<0.05). Conclusion: Digitized chest X-rays are not a reliable method for primary detection of pulmonary infiltrations after bone marrow transplantation. Individual risk factors have to be taken into consideration to indicate further diagnostic methods such as computed tomography at an earlier time. (orig.) [German] Ziel: Wertigkeit der digitalen Thoraxaufnahme bei der Detektion pulmonaler Infiltrate bei knochenmarktransplantierten Patienten in der Aplasie. Methoden: Digitale Thoraxaufnahmen von 40 Patienten (21 Frauen, 19 Maenner) in Aplasie mit Fieber unklarer Genese wurden nach Zeichen pulmonaler Infiltrate ausgewertet und mit klinischen, laborchemischen, mikrobiologischen und bronchoskopischen Befunden korreliert. Zusaetzlich wurde ein

  14. Contribution à la statistique des diffusions. Estimation semiparamétrique et efficacité au second ordre.
    Agrégation et réduction de dimension pour le modèle de régression.

    OpenAIRE

    Dalalyan, Arnak S.

    2007-01-01

    Ce texte constitue une synthèse de mes travaux de recherche menés depuis 2000 en statistique mathématique. Ces travaux s'articulent autour de 4 thèmes: la statistique non paramétrique pour les processus de diffusion, efficacité au second ordre pour l'estimation semiparamétrique, agrégation par des poids exponentiels et réduction de dimension pour la régression non paramétrique. Le premier chapitre contient une description générale des résultats obtenus en les replaçant dans un contexte histor...

  15. Hétérogénéité spatiale d'un service de réseau, équité et efficacité collective : la distribution rurale d'électricité et la maîtrise de la demande

    OpenAIRE

    Nadaud, Franck

    2005-01-01

    Cette thèse a pour objet l'évolution de l'optimum économique sous contrainte d'équité territoriale de l'industrie électrique, industrie de réseau fixe présentant une hétérogénéité spatiale forte de ses conditions d'offre. Cette problématique porte sur l'analyse de l'évolution du régime de l'électrification rurale en France en termes d'efficacité économique et sociale. Il s'agit de prolonger une longue tradition de recherche du CIRED initiée au début des années 1980 par Louis Puiseux, dont les...

  16. La recherche d’efficacité

    OpenAIRE

    Mäsch, Nando

    2015-01-01

    À partir de l’exemple du Land de Rhénanie-Westphalie, l’auteur présente les conditions – et les contraintes – de travail des chefs d’établissement à la recherche d’une amélioration de la qualité éducative qui passe, notamment, par l’application du principe de subsidiarité au secteur scolaire.

  17. Influence de l'énergie de surface d'un tambour deshuileur sur son efficacité de relevage Influence of the Surface Energy of a Deoiling Drum on Its Gathering Efficiency

    Directory of Open Access Journals (Sweden)

    Aurelle Y.

    2006-11-01

    Full Text Available Au cours de cette étude est analysée l'influence de l'énergie de surface d'un tambour déshuileur sur son efficacité et sa sélectivité de relevage. Quatre tambours en acier inoxydable, en polychlorure de vinyle, en polypropylène et en dérivé fluorocarboné de tensions critiques de mouillage différentes sont testés comparativement en fonction de l'histoire de leur expositionvis-à-vis de phases hydrocarbure (kérosène et eau. Les essais réalisés montrent que seuls les tambours en dérivé fluorocarboné de très faible tension critique de mouillage s'avèrent intéressants pour des utilisations industrielles. En effet, ils présentent un comportement indépendant de l'histoire de leur exposition ce qui les rend très faciles à utiliser, sans précautions particulières, du fait de leur très grande sélectivité vis-à-vis des hydrocarbures. Par contre, les autres tambours, qui présentent des contributions polaires non négligeables à leur énergie de surface, ont des comportements vis-à-vis des hydrocarbures fonction de l'histoire de leur exposition et ne s'avèrent pas sélectifs vis-à-vis des hydrocarbures à récupérer. The aim of this article is to analyze the influence of the surface energy of a deoiling drum on its gathering efficiency and selectivity. The project consists in testing drums having the same size but made of materials having different surface energies so as to evaluate the influence of this key parameter that had previously been poorly analyzed. Four materials were chosen : stainless steel, polyvinyl chloride, polypropylene, and a fluorocarbon derivative. These materials are representative, a priori, of the behavior of most materials because of the position of their critical wetting tension (gamma c compared to the superficial tension values of water (72 dyn/cm and the hydrocarbon phases to be gathered (25 to 35 dyn/cm (Fig. 1. It should be noted that the fluorocarbon derivative drum tested was patented by

  18. Efficacité de la prévention de la transmission mère-enfant du Virus de l'Immunodéficience Humaine par le protocole 2010 de l'Organisation Mondiale de la Santé au Centre Médical Saint Camille de Ouagadougou (Burkina Faso)

    Science.gov (United States)

    OuédraogoYugbaré, Solange Odile; Zagré, Nikaise; Koueta, Fla; Dao, Lassina; Kam, Ludovic; Ouattara, Diarra Yé; Simporé, Jacques

    2015-01-01

    L’épidémie du Virus de l'Immunodéficience Humaine en milieu pédiatrique est surtout le résultat de la transmission mère-enfant. Notre étude a pour objectif de décrire l'efficacité de la prévention de la transmission mère-enfant du Virus de l'Immunodéficience Humaine par le protocole OMS 2010 (Option A et trithérapie) au centre médical saint Camille de Ouagadougou. Nous avons mené une étude d'une cohorte d'enfants suivis dans le cadre de la prévention de la transmission mère-enfant du Virus de l'Immunodéficience Humaine au centre médical saint Camille de Ouagadougou sur une période de 2 ans allant du 1er Janvier 2012 au 31 Décembre 2013. Nous avons obtenu l'accord de 4900 femmes enceintes pour le dépistage de l'infection du Virus de l'Immunodéficience Humaine et 238 gestantes ont été diagnostiquées séropositives soit 4,86% de séroprévalence. Les femmes étaient surtout infectées par le Virus de l'Immunodéficience Humaine avec de type I (95,38%)). La majorité était sous trithérapie (74,3%) et (25,7%) sous prophylaxie (option A). Les nouveau-nés (92,5%) ont reçu un traitement antirétroviral à base de névirapine dans les 72 heures après la naissance. L'allaitement sécurisé a été appliquée dans 78% des cas. Le taux global de transmission mère-enfant du VIH était de 3,6% avec 3% de transmission chez les enfants nés de mères sous trithérapie antirétrovirale et 6,3% dans les cas de prophylaxie antirétrovirale. Le facteur de risque de transmission a été le long délai du début d'administration des antirétroviraux chez le nouveau-né. La mortalité infantile à un an était de 3,5%. Cette étude a révélé l'efficacité de l'Option A et conforté celle de la trithérapie, le passage à l'Option B+ serait donc plus bénéfique. PMID:26966499

  19. Evaluation of the Energy Efficiency of a Fleet of Electric Vehicle for Eco-Driving Application Évaluation de l’efficacité énergétique d’une flotte de véhicules électriques dédiée à une application d’éco-conduite

    Directory of Open Access Journals (Sweden)

    Dib W.

    2012-09-01

    Full Text Available In this paper, an approach to evaluate the energy efficiency of an electrical vehicle during a short trip is addressed. This approach provides metrics that can be used to evaluate the potential of improvement achievable via intelligent eco-driving techniques and the performance actually achieved by any of them. It can be the basis for an evaluation of a fleet of vehicles and of a whole city for which an energy efficiency map could be derived, depending for instance of traffic management strategy. Experimental data are provided to illustrate the approach for a fleet of electric vehicles in an urban environment. The methods proposed are intended to be the basis of a driver assistance system oriented to optimal eco-driving. Dans cet article, nous proposons une approche pour évaluer l’efficacité énergétique d’un véhicule électrique lors d’un déplacement urbain. Cette approche fournit des outils permettant d’évaluer le gain énergétique réalisable par l’intermédiaire des techniques intelligentes d’éco-conduite. Cette approche peut être utilisée pour évaluer une flotte de véhicules, ainsi que pour élaborer une cartographie énergétique d’une ville. Des données expérimentales sont fournies pour illustrer cette approche sur une flotte de véhicules électriques dans un environnement urbain. Les méthodes d’éco-conduite proposées sont destinées à constituer la base d’un système d’assistance au conducteur.

  20. MASTURBATION ET THERAPEUTIQUE : L'EXEMPLE DU TRAITEMENT DES AUTEURS D'AGRESSIONS A CARACTERE SEXUEL

    OpenAIRE

    Le Bodic, Cédric

    2009-01-01

    Dans cet article, nous proposons de nous attarder sur le passage de la masturbation pathogène à la masturbation comme technique thérapeutique, dans le cadre particulier de l'agression sexuelle. Dans son cours consacré aux anormaux, Foucault renseigne sur la figure du masturbateur et propose, derrière une archéologie de l'anomalie, de concevoir que l'anormal tel qu'il se construit au XIXe siècle, naît de trois figures : le monstre, l'individu à corriger et le masturbateur ou l'enfant masturbat...

  1. Comment resoudre en pratique un probleme diagnostique ou therapeutique en suivant une demarche EBM?

    OpenAIRE

    Delvenne, Catherine; Pasleau, Françoise

    2000-01-01

    Evidence-Based Medicine (EBM) can be defined as the use of best current evidence from clinical research in making decisions about the care of individual patients. It consists of a process of turning clinical problems into questions and then locating the best available evidence to answer them, critically appraising the evidence for its validity and usefulness, and applying the findings to clinical practice. The present article presents the EBM principles and their application to diagnostic and...

  2. The therapy education in cancerology; L'education therapeutique en cancerologie

    Energy Technology Data Exchange (ETDEWEB)

    Charrier, S. [Centre d' Oncologie et de Radiotherapie de Chaumont-le-Bois, 52 - Chaumont (France); Feuvret, L. [Centre de Protontherapie d' Orsay (CPO), 91 - Orsay (France)

    2004-08-01

    The development in therapy education in the field of oncology represents a progress in the taking charge of patients. It reinforces the individual approach of the patient in considering this one not as a sick person bearer of a tumor but rather than a sick subject with desires and resistances. It is not a miracle and does not delete the traumatisms lived by the patient at the diagnosis announcement or the existential questions emerging for their life. (N.C.)

  3. Diabete de type 2 et medicaments anti-inflammatoires: nouvelles perspectives therapeutiques?

    OpenAIRE

    Esser, Nathalie; Paquot, Nicolas; Scheen, André

    2011-01-01

    It is now well accepted that a chronic, low-grade inflammation is observed in abdominal obesity, insulin resistance and type 2 diabetes mellitus, and that pro-inflammatory cytokines and oxidative stress play a role in the pathogenesis of type 2 diabetes. These new findings raise the question of whether antiinflammatory strategies may have a place in the prevention and treatment of type 2 diabetes. This review article describes the results obtained in studies on patients with metabolic syndrom...

  4. Effects of DTPA aerosol on lung contamination by lanthanum; Influence du DTPA en aerosol sur les contaminations pulmonaires au lanthane

    Energy Technology Data Exchange (ETDEWEB)

    Pasquier, C.; Voisin, D.; Thieblement, P.; Perrault, G.; Bayard, J. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1969-07-01

    Applying DTPA aerosol for the treatment of lung contamination by lanthanum we were able to determine its effectiveness as a function of time. Provided it was administered early during the two hours after exposure, over 50 per cent could be removed using lower therapeutic doses than those prescribed for other routes of administration. Its association with some enzymes did not enhance the chelator therapeutic effect. We also calculated the constant of passage of lanthanum through the alveolar wall and found a value of 0.016 mn{sup -1}. Finally, as we have discovered a large part cannot be mobilized by DTPA, we shall now study the physico-chemical mechanisms involved in this protection. (authors) [French] L'emploi du DTPA en aerosol dans le traitement des contaminations pulmonaires par le lanthane, nous a permis d'etablir et d'evaluer son efficacite en fonction du temps. A condition d'etre utilise precocement, dans les deux heures qui suivent la contamination, une fraction superieure a 50 pour cent peut etre eliminee et ceci avec des doses therapeutiques inferieures a celles preconisees pour les autres voies d'administration. L'association avec quelques autres enzymes n'a pas permis d'ameliorer l'effet therapeutique de ce chelateur. Nous avons egalement chiffre la constante de passage du lanthane a travers la barriere alveolaire dont la valeur est de l'ordre de 0.016 mn{sup -1} Enfin, la decouverte d'une importante partie non piegeable par le DTPA nous amene maintenant a etudier les mecanismes physico-chimiques de cette protection. (auteurs)

  5. Energy efficiency: utopia or reality?; Efficacite energetique: utopie ou realite?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2006-04-15

    In its 2006 allocution the world council on the energy WEC, analyzes the role of the energy efficiency in the energy life cycle. In spite of different objectives followed by the developing and developed countries, implement a world energy efficiency economy is a challenge possible by the cooperation.The WEC is an ideal forum for the information and experience exchange. (A.L.B.)

  6. Marrow aplasia following colchicine treatment for gouty arthritis.

    Science.gov (United States)

    Ferrannini, E; Pentimone, F

    1984-01-01

    A 69-year-old man was given 8 mg of colchicine intravenously to treat an acute attack of gout. A maintenance dose of 2 mg/day of oral colchicine was then used to prevent recurrence. Three months later, the patient developed thrombocytopenia, followed by leukopenia and then by anemia at three and four months distance, respectively. The patient had shown no signs of acute toxicity with intravenous colchicine, but liver enzymes were raised after two months of oral treatment. The sequential involvement of the three blood precursor lines, in the order to their physiological half-lives, suggests direct toxicity, rather than idiosyncrasy, due to slow accumulation of the drug within target cells. The prophylactic use of colchicine, especially in the elderly, is questioned. PMID:6532622

  7. Smart Battery Thermal Management for PHEV Efficiency Une gestion avancée de la thermique de la batterie basse tension de traction pour optimiser l’efficacité d’un véhicule hybride électrique rechargeable

    Directory of Open Access Journals (Sweden)

    Lefebvre L.

    2013-03-01

    la disponibilité d’énergie de traction électrique et la durabilité de la batterie. La conception du système de gestion thermique de la batterie basse tension doit donc prendre en compte les exigences requises de la chaîne de traction et du véhicule, la conception et l’architecture du pack batterie, les contraintes d’environnement, au moindre coût et au moindre poids, etc., tout en optimisant les compromis entre ces paramètres souvent antagonistes. Le processus de conception du thermomanagement de la batterie basse tension de traction fait l’objet de la première partie de cet article. Ce processus sera illustré par deux exemples, l’un mettant en oeuvre l’air en provenance de l’habitacle du véhicule et l’autre, par un refroidissement direct via le circuit de réfrigération du véhicule. Pour une application concrète, le processus de décision doit intégrer l’ensemble des modes de thermomanagement étudiés dans ce contexte et les différents paramètres et exigences pris en compte en tant que données d’entrée. La seconde partie de l’article présente un modèle de simulation thermoélectrique simplifié de la batterie basse tension de traction. Quelques résultats de calculs seront présentés à titre d’exemples dans deux perspectives différentes, d’une part, le dimensionnement thermique du système de thermomanagement, et d’autre part, l’optimisation du bilan énergétique du véhicule. Par ailleurs, ce modèle de simulation simplifié a également permis d’identifier et d’évaluer plusieurs stratégies pertinentes de gestion thermique de la batterie. Ces stratégies visent à améliorer l’efficacité et la performance du véhicule tout en ménageant la durée de vie de la batterie. La troisième partie présente certaines de ces stratégies. Parmi celles-ci, le post-refroidissement et le préconditionnement thermique de la batterie basse tension de traction, en préchauffage par conditions froides et en

  8. The non-conventional therapeutical indications of I 131; Les indications therapeutiques non conventionnelles de l`I 131

    Energy Technology Data Exchange (ETDEWEB)

    Delisle, M.J.; Schvartz, C.; Maes, B.; Vaudrey, C.; Pochart, J.M. [I.J.G. BP 171, 51056 Reims (France)

    1997-12-31

    In our therapeutic activity the non-conventional indications represent 5-10% relative to the indisputable indications which the hyperthyroidism in the second half of the life and the differential thyroid cancers are. In this paper our experience since 1966 is revised and confronted with the data of international literature. In the last almost 40 years we have treated 178 hyperthyroidism of which 17 were youngsters between 16 and 20 years old, 17 multi-nodular euthyroid goiters (MEG), 85 advanced cardiopathies and 8 Cordarone cardiopathies. The indications are precise: relapses after ATS or surgery in young subjects, counter-indications or surgery refusal for the MEGs and cardiologic indications. The long term surveillance was managed by an adequate code. Immediate morbidity is null. The efficiency is high in the hyperthyroidism treatment. The hypothyroidism is diagnosed and early treated. The reduction of the MEG mass is significant. An objective amelioration of the heart state was obtained (23%). The evaluation of the preventive effect of induced hyperthyroidism by Cordarone is underway. In conclusion, the enlargement of indications concerns mainly the hyperthyroidism in young subjects. In order to avoid carcinogenic risks we excluded the children under 16 years, excepting for special situations. This extension to the procreation age imposes a rigorous application of contraception and radiation protection instructions and needs a prolonged evaluation of results

  9. De la variation de l'etayage logopedique comme outil therapeutique (Variation of Speech Therapy Scaffolding as a Therapeutic Tool).

    Science.gov (United States)

    Gaillard, Douchka

    1998-01-01

    Drawing on research on techniques for scaffolding in speech therapy for victims of Alzheimer's Disease, some considerations in determining appropriate scaffolding in speech therapist-client interactions at four levels of interaction (initial, those involving early language activities, discourse interactions, and turn-taking) are discussed.…

  10. Investigation of Methane Hydrate Formation in a Recirculating Flow Loop: Modeling of the Kinetics and Tests of Efficiency of Chemical Additives on Hydrate Inhibition Étude de la formation de l'hydrate de méthane dans une conduite de recirculation : modélisation de la cinétique et tests d'efficacité d'additifs chimiques inhibiteurs d'hydrates de gaz

    Directory of Open Access Journals (Sweden)

    Peytavy J. L.

    2006-12-01

    obstruer les lignes de transport et les installations de traitement d'effluents pétroliers. Pour contrôler ces dépôts d'hydrates, on utilise fréquemment, comme inhibiteurs, le méthanol ou les glycols. Aujourd'hui, les équilibres thermodynamiques des hydrates de gaz sont bien connus ; par contre, les cinétiques de formation et de croissance doivent être étudiées afin de mettre en évidence de nouveaux moyens de contrôle grâce à l'étude des mécanismes de formation des hydrates hors équilibre. Le présent travail propose une étude de la cinétique de formation de l'hydrate de méthane dans une boucle de recirculation de laboratoire dans laquelle le mélange liquide, saturé de méthane, circule à une pression maximum de 75 bar. La pression constante au cours des expériences est maintenue par ajout de gaz frais. Dans un premier temps, nous avons étudié les effets de la pression (35-75 bar, de la vitesse d'écoulement du liquide (0,5-3 m/s, de la rampe de refroidissement (2-15°C/h et de la quantité d'hydrocarbure présent dans la charge (0-96 % sur les cinétiques de formation de l'hydrate. Nous proposons ensuite une nouvelle méthode de prédiction, en premier lieu, des conditions thermodynamiques (pression et température correspondant aux valeurs de vitesse de croissance maximum de l'hydrate, puis de ces vitesses de croissance maximum. Nous avons obtenu un bon accord entre valeurs expérimentales et calculées. Enfin, nous avons évalué, en utilisant la procédure expérimentale décrite précédemment, l'efficacité de quelques inhibiteurs cinétiques et tensioactifs mis au point pour éviter, soit la nucléation, soit la croissance des cristaux et l'agglomératon de particules d'hydrates de méthane.

  11. Chirurgie filtrante du glaucome: sécurité et efficacité

    OpenAIRE

    Varga, Zsolt

    2015-01-01

    Le Glaucome est l’une des causes principales de cécité dans le monde. Le nombre de personnes atteintes devrait presque doubler d’ici 25 ans en raison du vieillissement de la population. La chirurgie du glaucome est effectuée pour réduire la pression intraoculaire et arrêter ou ralentir la progression du glaucome avancé non-contrôlé, afin d’éviter la perte de vision et préserver la qualité de vie. De nouvelles interventions chirurgicales ont été développées avec pour objectif de réduire le tau...

  12. La miraculeuse efficacité de la théorie quantique

    CERN Document Server

    Miné, Philippe

    2014-01-01

    Avec les théories de la relativité, la physique quantique est une de ces révolutions conceptuelles qui ont, au cours du XXe siècle, tout changé à notre compréhension de la nature. Si fascinantes que soient ses applications – laser, cryptographie, GPS, ordinateur, imagerie médicale –, la physique quantique fait cependant intervenir des paradoxes déroutants pour notre logique ordinaire. Pénétrer les arcanes du monde quantique, c’est donc aussi accepter d’utiliser le langage des équations, dont les auteurs donnent ici une approche accessible et graduée, n’excédant pas le niveau du premier cycle universitaire et n’oubliant jamais les vertus de l’approche historique. Se révèle ainsi l’univers fabuleux des particules élémentaires, des forces fondamentales de la nature, de la cosmologie et des énigmes de l’espace-temps, thèmes sur lesquels doit s’édifier toute réflexion moderne sur la nature et ses lois. Mais acquérir une certaine familiarité avec le monde quantique ne sig...

  13. Image, créativité et sentiment d’efficacité personnelle

    OpenAIRE

    Hébrard, Véronique

    2014-01-01

    L’utilisation de l’image fixe et mobile rendue possible par les TICE (technologies de l’information et de la communication pour l’enseignement) peut être l’occasion d’activités pédagogiques visant à faire percevoir à des apprenants en difficulté d’apprentissage linguistique, l’étendue de leur potentiel créatif et cognitif. L’activité qui est présentée ici décrit les différentes étapes de la réalisation d’un commentaire oral de type journalistique sur un support vidéo à caractère professionnel...

  14. Electricity: France tries to restore efficiency; Electricite: la France tente de retablir l'efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Chauveau, L.; Mulot, R.

    2012-02-15

    While recalling some data regarding the French energy consumption and its costs for the French households, the authors evoke Premio, the oldest experimental smart grid in Europe, and describe its operation. They comment the experience made in Brittany where households are warned when a consumption peak occurs, and will be equipped with devices which will automatically cut the electricity in this situation. They outline the role smart grids could have in energy savings. They also comment the possibilities of the Linky smart meter and the associated network security problems

  15. Social accommodation and energy efficiency dossier; Dossier habitat social et efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Despretz, H. [Agence de l' Environnement et de la Maitrise de l' Energie, ADEME, 75 - Paris (France); Morlot, R. [Centre Scientifique et Technique du Batiment, (CSTB), 75 - Paris (France); Gibert, M. [OPAC 38, Grenoble (France); Marichez, J.M. [CDHR 62 - Arras (France); Bouchardeau, Ph. [ADIL 26 (France); Sidler, O. [Enertech, 26 - Felines sur Rimandoule (France); Hamadou, H. [Mouvement pour les Villages d' Enfants, MVE (France)

    2001-09-01

    This dossier takes stock of the experiences and programs in progress in some French regions about the enforcement of the new thermal regulation from June 2001 in social accommodations: recall of the principles of the new regulation, practices and needs for renewable energy uses in accommodations for underprivileged people; campaign of sensitization to water, electricity and heat saving; the energy policy of the OPAC 38, a social accommodation organization of Grenoble (SE France); the energy mastery in Northern France rural accommodations; the social stake of energy mastery, its impact on standard of living, health and public finances; the first lessons gained from the scheduled operations of improvement of accommodations (rehabilitation of private buildings) in Drome region (SE France); the electricity mastery action of Montreuil-Vincennes Energie organization for the evaluation of the different specific uses of electricity in common and private parts of social apartment buildings. (J.S.)

  16. Méta-analyse et efficacité des psychothérapies : Faits et fictions

    OpenAIRE

    Zimmermann G.; Pomini V.

    2013-01-01

    In a political environment increasingly concerned with the problem of escalating health care costs, the issue of psychotherapy efficacy evaluation is still debated. Historically, this debate started after Eysenck (1952) published a famous article suggesting that average improvement from pre- to post-therapy has nothing to do with psychotherapy participation, but something that would tend to happen anyway ("spontaneous remission"). Wanting to prove that psychotherapy was effective (Glass, 2000...

  17. Corporate gouvernance: l’efficacité juridique et marketing des codes de conduite

    OpenAIRE

    Sylvie AVIGNON; Dominique BONET FERNANDEZ

    2014-01-01

    Corporate social responsibility and ethics are part of business governance today and represents new ways of market adjustment for companies in quest of legitimacy in an uncertain environment. Tools such as codes of conduct or charts aim at clarifying busi

  18. Diversité des processus d'apprentissage et efficacité dynamique des structures industrielles

    OpenAIRE

    Patrick Llerena; Vanessa Oltra

    2002-01-01

    [fre] Cet article est consacré à l'étude de la diversité des processus d'apprentissage des firmes et leur impact sur la dynamique industrielle. Nous présentons un modèle de simulation qui permet d'analyser les interactions entre les processus d'apprentissage et d'innovation des firmes et leurs effets sur l'évolution de la structure industrielle et les performances technologiques de l'industrie. Notre contribution consiste à proposer une modélisation originale des processus d'apprentissage int...

  19. Le Conseil d'État, frein à l'efficacité administrative ?

    Directory of Open Access Journals (Sweden)

    Odile Daurmont

    2011-09-01

    Full Text Available IntroductionLe lecteur ne trouvera pas ci-après de réponse positive ou négative à la question posée dans l'intitulé. Le but de cette communication n'étant pas de faire l'apologie du Conseil d'État ni l'inverse d'ailleurs mais seulement de fournir des éléments d'information et de réflexion qui permettront au lecteur de se forger une opinion en meilleure connaissance de cause.Il est en effet manifeste que nombreux sont ceux qui ignorent le rôle réel du Conseil d'État ou qui n'ont qu'une informa...

  20. Efficacité des réglementations foncières en milieu rural africain

    Directory of Open Access Journals (Sweden)

    Biaou, G.

    1994-01-01

    Full Text Available Effectiveness Of Land Tenure Systems Regulation In African Rural Areas. Ten cycling heifers were studied during 11 months (mo to determine the possible influence of some environmental parameters of a high altitude and tropical zone, on estrous cycle and estrus duration, hour of estrus presentation and blood progesterone levels. The climatic variables studied were rainfall, humidity, temperature, and sunshine duration. Estrous cycle duration varied between 17 and 27 days (d with a mean value of 21.1d. Estrus duration varied between 9 and 16 h, with a mean value of 10.64 h. The percent distribution of estrus appearance at different times of a day, was as follows : 25 % occurred between 1800 and 0600 ; 37.5 % o between 0630 and 1000 ; 29.4 % between 1030 and 1600 ; and 8.1 % between 1630 and 1730. Progesterone levels in days 0 (estrus, 5, 10, 15 and 20 of the estrous cycle had mean values of 0.0, 1.27, 3.77, 4.80 and 0.32 ng/ml, respectively. Statistical analysis showed no effect of environmental parameters on the physiological variables and on the levels of the hormones analysed throughout the period studied. It seems that Holstein cattle adapt well to the climatic conditions of Bogota.

  1. Le vaccin antipneumococcique. L'efficacité chez les 55 ans et plus.

    OpenAIRE

    MARCHAND, R

    1993-01-01

    Three recent articles are examined in which research using the double-blind randomised clinical trial, the case control study, and the quasi-cohort study is described. Understanding the advantages and disadvantages of these methods makes it easier to grasp the pneumococcal vaccine controversy and make an informed choice.

  2. Etude in vitro de l'efficacité antifongique de la Piroctone olamine sur Malassezia pachydermatis

    OpenAIRE

    Tané, Elisabeth

    2006-01-01

    Le but de cette étude est d évaluer l'action antifongique de la Piroctone olamine sur Malassezia pachydermatis in vitro. De la Piroctone olamine en poudre, à différentes concentrations allant de 43 à 344 mg/m , est solubilisée puis déposée sur des boîtes de Pétri. Dans un premier temps, l'auteur étudie l'effet préventif antifongique de la Piroctone olamine en répartissant le principe actif sur la gélose de Sabouraud, avant d'ensemencer les levures. Dans un deuxième temps, il applique la Piroc...

  3. The nuclear debate: ethics versus effectiveness; Morale et efficacite dans le debat nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Lambert, D

    2009-04-15

    Following some political maneuvering, a new debate on the future of nuclear deterrence is about to resurface. And a first deadline has been set by the need to restore the strategic balance between the United States and Russia before the START Treaty ends on 5 December 2009, as well as by preparation for the next NPT Review Conference. Perception of the main threat has changed, but so have concepts of deterrence. Far from outmoded, deterrence forms part of a broader vision in which realism has the edge over idealism. (author)

  4. Energy efficiency : an economic stimulator; Efficacite energetique : un moteur economique vert

    Energy Technology Data Exchange (ETDEWEB)

    Contant, A.

    2009-04-01

    In an effort to meet Quebec's energy requirements projected for 2015, Hydro-Quebec along with its partners and clients will invest $3 billion in energy efficiency. Quebec's Energy Efficiency Agency, Canada's Office of Energy Efficiency and the Federation of Canadian Municipalities (FCM) green municipal fund have all contributed to energy efficiency projects to stimulate the economy. These measures are expected to create nearly 4000 jobs in Quebec for electricians, heating contractors, plumbers and building professionals. This investment will also benefit the suppliers and distributors of electrical materials as well as the forestry industry, cement manufacturers, and specialized engineers. Since the benefits of energy efficiency upgrades are already well established, projects can get underway without further studies. The proposed energy efficiency projects can be applied anywhere in the province of Quebec and are not intended for any specific region. To name a few, the projects have included energy upgrades in an arena in Riviere du Loup, the Montreal Health Institute's head office building, and traffic light upgrades in Levis, Quebec. The article noted that energy efficiency upgrades made in the office buildings of Alcan, IBM, Molson and Bombardier have all resulted in at least a 5 per cent reduction in electricity use. All these changes have been good for the environment, even though Quebec's electricity is generated almost entirely from renewable energy sources. 6 figs.

  5. When does action comprehension need motor involvement? Evidence from upper limb aplasia.

    Science.gov (United States)

    Vannuscorps, Gilles; Andres, Michael; Pillon, Agnesa

    2013-01-01

    Motor theories of action comprehension claim that comprehending the meaning of an action performed by a conspecific relies on the perceiver's own motor representation of the same action. According to this view, whether an action belongs to the motor repertoire of the perceiver should impact the ease by which this action is comprehended. We tested this prediction by assessing the ability of an individual (D.C.) born without upper limbs to comprehend actions involving hands (e.g., throwing) or other body parts (e.g., jumping). The tests used a range of different visual stimuli differing in the kind of information provided. The results showed that D.C. was as accurate and fast as control participants in comprehending natural video and photographic presentations of both manual and nonmanual actions, as well as pantomimes. However, he was selectively impaired at identifying point-light animations of manual actions. This impairment was not due to a difficulty in processing kinematic information per se. D.C. was indeed as accurate as control participants in two additional tests requiring a fine-grained analysis of an actor's arm or whole-body movements. These results challenge motor theories of action comprehension by showing that the visual analysis of body shape and motion provides sufficient input for comprehending observed actions. However, when body shape information is sparsely available, motor involvement becomes critical to interpret observed actions. We suggest that, with natural human movement stimuli, motor representations contribute to action comprehension each time visual information is incomplete or ambiguous. PMID:24215324

  6. Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia.

    Science.gov (United States)

    Bär, Christian; Povedano, Juan Manuel; Serrano, Rosa; Benitez-Buelga, Carlos; Popkes, Miriam; Formentini, Ivan; Bobadilla, Maria; Bosch, Fatima; Blasco, Maria A

    2016-04-01

    Aplastic anemia is a fatal bone marrow disorder characterized by peripheral pancytopenia and marrow hypoplasia. The disease can be hereditary or acquired and develops at any stage of life. A subgroup of the inherited form is caused by replicative impairment of hematopoietic stem and progenitor cells due to very short telomeres as a result of mutations in telomerase and other telomere components. Abnormal telomere shortening is also described in cases of acquired aplastic anemia, most likely secondary to increased turnover of bone marrow stem and progenitor cells. Here, we test the therapeutic efficacy of telomerase activation by using adeno-associated virus (AAV)9 gene therapy vectors carrying the telomeraseTertgene in 2 independent mouse models of aplastic anemia due to short telomeres (Trf1- andTert-deficient mice). We find that a high dose of AAV9-Terttargets the bone marrow compartment, including hematopoietic stem cells. AAV9-Terttreatment after telomere attrition in bone marrow cells rescues aplastic anemia and mouse survival compared with mice treated with the empty vector. Improved survival is associated with a significant increase in telomere length in peripheral blood and bone marrow cells, as well as improved blood counts. These findings indicate that telomerase gene therapy represents a novel therapeutic strategy to treat aplastic anemia provoked or associated with short telomeres. PMID:26903545

  7. Failure of Femoral Access to Electrophysiological Evaluation Due to Aplasia of the Inferior Vena Cava

    Science.gov (United States)

    Parahuleva, Mariana S.; Burgazli, Mehmet; Soydan, Nedim; Franzen, Wolfgang; Güttler, Norbert; Erdogan, Ali

    2016-01-01

    We report an interesting case of a man with a persistent left superior vena cava (PLSVC) with left azygos vein who underwent electrophysiological evaluation. Further evaluation revealed congenital dilated azygos vein, while a segment connecting the inferior vena cava (IVC) to the hepatic vein and right atrium was missing. The azygos vein drained into the superior vena cava, and the hepatic veins drained directly into the right atrium. The patient did not have congenital anomalies of the remaining thoracoabdominal vasculature. PMID:27257399

  8. Pathology of renal dysplasia and bladder aplasia-hypoplasia in a flock of sheep.

    Science.gov (United States)

    O'Toole, D; Jeffrey, M; Jones, T; Morgan, G; Green, R

    1993-10-01

    Congenital renal disease was detected in a flock of sheep in the English Midlands over 2 successive years (1982 and 1983). A Suffolk ram was removed from the flock and test mated to unrelated Suffolk ewes in another flock; 14 of the resulting 43 lambs born in 1984 had an identical congenital renal disease. Kidneys were examined microscopically from 60 clinically affected neonatal lambs. Kidneys from 7 of the 60 clinically affected neonatal lambs (1, 1983; 6, 1984) were examined ultrastructurally and compared with kidneys from 3 healthy unrelated neonatal lambs. Most affected lambs examined (52/60) had bilaterally small kidneys (multicystic and of normal size to markedly enlarged (5/60 lambs). The bladder was absent or vestigial in most lambs. Microscopically, poorly differentiated ("primitive") tubules were present in renal cortex and medulla. Proximal convoluted tubules, where present, were formed by epithelial cells with distinctive round weakly autofluorescent intracytoplasmic inclusions with the ultrastructural appearance of atypical lysosomes. Loops of Henle, distal convoluted tubules, and juxtaglomerular-peripolar cell complexes were largely absent. Glomerular changes were minimal. Cystic dilatation of nephrons was restricted to proximal convoluted tubules lined by vacuolated epithelium. This distinctive congenital renal dysplasia of sheep was most likely inherited as a dominant trait with complete penetrance. PMID:8286460

  9. Small ureterocele-like Gartner's duct cyst associated with ipsilateral renal aplasia: a case report

    International Nuclear Information System (INIS)

    A four-year-old girl presented with abdominal pain. There was no history of fever, recurrent attacks of urinary infections or other systemic symptoms. Clinical examination was within normal limits. An ultrasonogram of the abdomen revealed a well-defined sonolucent lesion in the posterolateral wall of the urinary bladder protruding into the lumen of the bladder. The left kidney was absent. An ureterocele was suspected. Excretory urography confirmed an absent left kidney with typical ureterocele-like impression in the bladder base. Renography with Tc99m dimercaptosuccinic acid showed normal function in the right kidney. Contrast-enhanced CT demonstrated a tubulocystic lesion in the bladder base protruding into the bladder. Cystoscopy showed an extrinsic impression with no internal opening. As the patient was asymptomatic, the lesion was followed for 4 years and there was no progression of the lesion. Copyright (2001) Blackwell Science Pty Ltd

  10. Medullary aplasia secondary to an irradiation accident: Treatment options and evolution of the concepts

    International Nuclear Information System (INIS)

    Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods. (author)

  11. Conclusion: imaging in strategy of endocrine diagnosis and therapeutics; Place de l`imagerie dans la strategie d`exploration et de suivi therapeutique des pathologies endocriniennes

    Energy Technology Data Exchange (ETDEWEB)

    Mornex, R. [Hopital Edouard-Herriot, 69 - Lyon (France)

    1995-12-31

    Images in medicine have to help the doctor in a diagnostic or therapeutic aim. The choice must be made in function of pathology or organ as known (it is not necessary to ask for a computed tomography where we know that only an echography can give the answer to the question we ask ), the criteria must stay the best performance for the cheapest price, but the quality of interpretation is a more important thing. It is important to avoid a lot of examinations which do not give better informations but are heavy to endure for the patients. In conclusion, the aim of this kind of proceedings is to assure to the patients who come confidently to us, the best service at the less constraints price without forgetting that a conclusion depends on a given methodological situation and reminding of beside machines we have not to forget the men.

  12. EFFET DE LA STIMULATION DU NOYAU PEDONCULOPONTIN SUR LES TROUBLES DE LA MARCHE ET LE FREEZING DANS LA MALADIE DE PARKINSON : ETUDE CLINIQUE ET THERAPEUTIQUE

    OpenAIRE

    Ferraye, Murielle

    2010-01-01

    Gait disorders in the healthy elderly are a major public health concern. We believed understanding Parkinson Disease (PD) typical gait disorders would bring some insights into the mechanisms of gait disorders in the elderly. In PD, their response to levodopa and to subthalamic nucleus stimulation is often heterogeneous, suggesting they are controlled at different levels of the CNS. In particular, there is convergent evidence of early alterations in cholinergic neurotransmission responsible fo...

  13. APPORTS DE L'IMMUNISATION GENIQUE A L'OBTENTION D'ANTICORPS A VISEE THERAPEUTIQUE : VERS UNE IMMUNOTHERAPIE DES MALADIES A PRIONS

    OpenAIRE

    Alexandrenne, Coralie

    2007-01-01

    Les maladies à prions sont des maladies neurodégénératives fatales, affectant de nombreuses espèces animales, dont l'homme. Elles se caractérisent par l'accumulation, notamment dans le système nerveux central, d'une isoforme anormale d'une protéine membranaire ubiquiste, la protéine prion cellulaire (PrPc). Il n'existe à l'heure actuelle aucun traitement réellement efficace. Ces dernières années, l'immunothérapie, passive et active, basée sur l'utilisation d'anticorps dirigés contre la confor...

  14. Retrospective evaluation of diagnosis and therapy impact of DaTSCAN;Evaluation retrospective de l'impact diagnostique et therapeutique du DaTSCAN

    Energy Technology Data Exchange (ETDEWEB)

    Tabouret-Viaud, C.; Salmon, F.; Perdrisot, R. [CHU de Poitiers, Service de medecine nucleaire, 86 - Poitiers (France); Du Boisgueheneuc, F. [CHU de Poitiers, Service de neurologie, CM2R, 86 - Poitiers (France); Simmat, G. [CHHL Poitiers, service de neurophysiologie clinique, 86 - Poitiers (France); Merlet-Chicoine, I.; Paccalin, M. [CHU de Poitiers, Service de geriatrie, 86 - Poitiers (France); Tournoux-Facon, C. [CHU de Poitiers, centre d' investigation clinique P802, 86 - Poitiers (France)

    2010-05-15

    The objective is to evaluate the clinical impact of the cerebral scintigraphy with DaTSCAN. The evaluation criteria are changing the diagnosis orientation and changing the therapeutic management. Conclusions: In this series of 70 patients, DaTSCAN contributed to a change or a diagnostic accuracy in 66% of patients and a change of in drug therapy in 68% of patients.These results support the use of this expensive drug. (N.C.)

  15. A new therapeutic approach of keloids in Cameroon: post-operative radiotherapy. Une nouvelle approche therapeutique des cheloides au Cameroun: la radiotherapie postoperatoire

    Energy Technology Data Exchange (ETDEWEB)

    Mouele Sone, A.; Ntone Ntone, F.; Ngbangako, M.C. (Hopital General, Douala (Cameroon))

    1993-01-01

    A new therapeutic approach of keloids has been introduced since the establishment of Radiation therapy in Cameroon. Seventeen patients have been treated since April 1989 by surgical excision followed within 24 - 72 hours by external radiotherapy with a total dose of 12 to 20 Gy administered in 3 -5 fractions. All the patients were irradiated with cobalt 60. Fourteen patients were observed 6 months after treatment; 12 of them (85%) were free of the disease. One year after, 6 patients out of 8 no longer presented out of keloids. The secondary effects observed within 2 months after treatment were a mild inflammation of the breast after partial irradiation of the mammary gland and a delayed healing after excision of the keloid with electrical cauterization. All symptoms disappeared without any sequelae.

  16. Chemoradiotherapy in head and neck squamous cell carcinoma: focus on targeted therapies; La chimioradiotherapie des carcinomes epidermoides des voies aerodigestives superieures: point sur les therapeutiques ciblees

    Energy Technology Data Exchange (ETDEWEB)

    Bozec, A. [Centre Antoine-Lacassagne, Dept. de Chirurgie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Thariat, J.; Bensadoun, R.J. [Centre Antoine-Lacassagne, Dept. de Radiotherapie, Institut Universitaire de la Face et du Cou, 06 - Nice (France); Milano, G. [Centre Antoine-Lacassagne, Unite d' Oncopharmacologie, Institut Universitaire de la Face et du Cou, 06 - Nice (France)

    2008-01-15

    Radiotherapy is an essential treatment for many patients with head and neck squamous cell carcinoma. Its association with molecular targeted therapies represents a real progress. Among the recent advances in the molecular targeted therapy of cancer, the applications centred on E.G.F.R. are currently the most promising and the most advanced at clinical level. Considering the set of therapeutic tools targeting E.G.F.R., there are at present two well-identified emerging categories of drugs with monoclonal antibodies, on the one hand, and tyrosine kinase inhibitors, on the other. In many preclinical studies, the combination of anti-E.G.F.R. drugs with irradiation has led to additive or supra-additive cytotoxic effects. Furthermore, anti-angiogenic agents have shown promising results in association with anti-E.G.F.R. drugs and radiotherapy. This research effort has recently produced encouraging clinical results in advanced head and neck cancer with combination of cetuximab (an anti-E.G.F.R. monoclonal antibody) with irradiation with a significant impact on patient survival. Active and efficient clinical research is currently ongoing to determine the place of molecular targeted therapies in the treatment of head and neck cancer, particularly in association with radiotherapy. (authors)

  17. Therapeutic results and prognostic factors after irradiation of loco-regional prostate cancer. La radiotherapie du cancer de la prostate au stade locoregional: resultats therapeutiques et facteurs pronostiques

    Energy Technology Data Exchange (ETDEWEB)

    Debrigode, C.; Dubois, J.; Hay, H.M.; Astre, C. (CRLC Val d' Aurelle, 34 -Montpellier (France)); Savu, N.M. (Institut d' Oncologie, Bucharest (Romania))

    1994-01-01

    The present study concerns 140 patients with loco-regional prostatic cancer, treated with external beam irradiation at the CRLC Val-d'Aurelle in Montpellier, France, between 1982 and 1988, with a minimum of 54 months follow-up. The local control after radiotherapy is 78.6%, all stages and histological grades combined. The median overall survival is 114 months and the median disease-free survival 59 months. The most frequent modality of treatment failure is metastatic disease, isolated (32.8%) or combined to local relapse (10%). The rate of urinary intolerance symptoms during treatment was 87.1 and 80.6% for the digestive ones. The late urinary complications and sequellae rate was 21.4% for the cystitis-type and 12.9% for post-radiotherapy urethral structures; the latter has imposed in 2/3 of cases one or more trans-urethral resections that never showed pathological signs of recurrence. Digestive complications and sequellae occurred in 31.3% of the patients; in the latter group there were two internal digestive fistulae which needed surgical treatment and three postradiotherapeutic stenosis of the anal canal. The prognostic factors revealed by statistical analysis are clinical stage, pathological grade for overall and disease-free survival, age for overall survival and trans-urethral resection for disease-free survival, the latter being equally a risk factor for cystitis-type complications and urethral structures. (authors). 26 refs., 8 figs., 7 tabs.

  18. Image, créativité et sentiment d’efficacité personnelle Image, creativity and self-efficacy

    OpenAIRE

    Véronique Hébrard

    2012-01-01

    L’utilisation de l’image fixe et mobile rendue possible par les TICE (technologies de l’information et de la communication pour l’enseignement) peut être l’occasion d’activités pédagogiques visant à faire percevoir à des apprenants en difficulté d’apprentissage linguistique, l’étendue de leur potentiel créatif et cognitif. L’activité qui est présentée ici décrit les différentes étapes de la réalisation d’un commentaire oral de type journalistique sur un support vidéo à caractère professionnel...

  19. Image, créativité et sentiment d’efficacité personnelle Image, creativity and self-efficacy

    Directory of Open Access Journals (Sweden)

    Véronique Hébrard

    2012-04-01

    Full Text Available L’utilisation de l’image fixe et mobile rendue possible par les TICE (technologies de l’information et de la communication pour l’enseignement peut être l’occasion d’activités pédagogiques visant à faire percevoir à des apprenants en difficulté d’apprentissage linguistique, l’étendue de leur potentiel créatif et cognitif. L’activité qui est présentée ici décrit les différentes étapes de la réalisation d’un commentaire oral de type journalistique sur un support vidéo à caractère professionnel. Cet exercice s’est avéré particulièrement bien adapté au public visé.The use of images with ICTE (Information and Communication Technology in Education provides opportunities for learning experiences aimed at making weaker language learners perceive their full creative and cognitive potential. The learning activity which is presented here describes the different stages of the creation and recording of the oral narration for a professional video. This exercise seems to be particulary well adapted to the target public.

  20. Fonctionnement et efficacité du comité d’audit : une analyse des interactions entre les participants

    OpenAIRE

    Compernolle, Tiphaine

    2011-01-01

    This research tries to understand audit committee’s working and effectiveness. It aims to open the audit committee black box by analyzing the interactions between participants. The approach is comprehensive, based on analysis of 59 interviews with attendees of 32 CAC 40 companies’ audit committees. Impression management is a central phenomenon in such committee’s meetings. The risk of losing face, which is not felt in the same way by the attendees depending on their status, is a central motiv...

  1. Static and dynamic efficiency of white certificate schemes; L'efficacite statique et dynamique des dispositifs de -certificats blancs-

    Energy Technology Data Exchange (ETDEWEB)

    Giraudet, L.G. [CIRED-ENPC, 94 - Nogent-sur-Marne (France); Finon, D. [CIRED-CNRS, 94 - Nogent-sur-Marne (France)

    2011-07-15

    White Certificate Schemes mandate energy companies to promote energy efficiency through flexibility mechanisms, including the trading of energy savings. They can be characterized as a quantity-based, baseline-and-credit system for the diffusion of energy efficient technologies. This paper compares experiences with White Certificate Schemes in Great Britain, Italy and France, in order to identify the basic drivers of each, and ultimately offer an original interpretation as an adaptive instrument, in the sense that it can take different forms in response to specific institutional contexts. A first analysis shows that Schemes perform well in terms of static efficiency, i.e. they are cost-effective and generate net social benefits over the period considered, though with large discrepancies rooted in different technological potentials. Regarding dynamic efficiency, i.e. the ability to induce and sustain technological change over the long haul, market transformation occurred in Great Britain, but was poorly incentivized in Italy and France by inadequate compliance cost recovery rules. Substantial organizational change has occurred in every country, mainly by strengthening vertical relationships between obliged parties and upstream businesses. Overall, the obligation (rather than the market component) drives the early phases of the Schemes. (authors)

  2. Localisation dans les Réseaux de Capteurs: Protocoles de Communication et Efficacité Energétique

    OpenAIRE

    Tanvir, Sadaf

    2010-01-01

    This thesis deals with localization and energy consumption in Wireless Sensor Networks (WSN). Communication cost is the major source of energy consumption during localization process in WSN. Carrying out WSN localization is a cooperative process throughout the whole network. There are many ways of organizing this cooperation. We propose three such possibilities in the form of our contributed protocols. Cooperation among distributed nodes generates many radio transmissions. Radio broadcasting ...

  3. Influence du sentiment d’efficacité informatique sur les usages d’internet des étudiants

    OpenAIRE

    Faurie, Isabelle; van de Leemput, Cécile

    2011-01-01

    Face au développement des supports informatiques et au recours aux technologies de l’information et de la communication (TIC) dans l’enseignement supérieur et l’insertion socioprofessionnelle, cet article se focalise sur une compétence transversale majeure : la maîtrise de l’informatique et d’internet. L’étude évalue les déterminants principaux des usages d’internet par les étudiants, en distinguant les usages en général et les usages spécifiques aux études. Les résultats montrent que ces usa...

  4. FEATURES OF THE X-RAY ANATOMICAL CONDITIONS OF THE FOOT AND ANKLE IN CHILDREN WITH FIBULAR APLASIA

    Directory of Open Access Journals (Sweden)

    Dmitry Stepanovich Buklaev

    2013-03-01

    Full Text Available The article contains the results of the analysis of radiographs of the foot and ankle in 84 children with malformations of the fibula. We found that infants’ relation to the ankle joint is often normal, as in the sagittal and frontal planes. With increasing age the number of posterior subluxation increases as well as anteriorly, laterally. Also dislocations of the foot were presented. The most significant relationships were violations of the subtalar joint. There were pronation, supinatsion, positions of calcaneus bone and its lateroposition, which was the most frequent cause of valgus deformity. Also we found a violation of the form of the talus such as a flattening of the block, smoothing of the neck. In rare cases of the varus deformity of the foot abnormalities of the tarsal bones were observed.

  5. Allogeneic Th1 Cells Home to Host Bone Marrow and Spleen and Mediate IFNγ-Dependent Aplasia

    OpenAIRE

    Chewning, Joseph H.; Zhang, Weiwei; Randolph, David A.; Swindle, C. Scott; Schoeb, Trenton R.; Weaver, Casey T.

    2013-01-01

    Bone marrow graft failure and poor graft function are frequent complications following hematopoietic stem cell transplantation and result in significant morbidity and mortality. Both conditions are associated with graft versus host disease (GVHD), although the mechanism remains undefined. Here we show in two distinct murine models of GVHD (complete MHC- and class II-disparate) that mimic human peripheral blood stem cell transplantation that Th1 CD4+ cells induce bone marrow failure in allogen...

  6. Gene therapy strategy to reduced bone marrow aplasia: evaluation in cynomolgus macaque exposed to a gamma total body irradiation

    International Nuclear Information System (INIS)

    The aim of this work was to assess whether direct intra-marrow injection of an adeno-viral vector expressing human IL-1α gene stimulates hematopoiesis in healthy non-irradiated and gamma irradiated cynomolgus macaques. In the first hand, we have evaluated the feasibility of this gene therapy strategy in two healthy non-irradiated macaques. In this work, we have observed an increase of neutrophil, monocyte and platelets in the two animals treated with the therapeutic construct. This effect was associated with no abnormal clinical side effect. On the other hand, we have evaluated this strategy in non-human primate exposed to a sublethal gamma irradiation. Two of three animals treated by the therapeutic construct reduced significantly the neutropenia, thrombocytopenia and anemia radio-induced. In conclusion, this gene therapy strategy gave a similar clinical benefit comparatively to systemic administration of huIL-1α but without severe side effect. (author)

  7. Reduced BMP Signaling Results in Hindlimb Fusion with Lethal Pelvic/Urogenital Organ Aplasia: A New Mouse Model of Sirenomelia

    OpenAIRE

    Suzuki, Kentaro; Adachi, Yasuha; Numata, Tomokazu; Nakada, Shoko; Yanagita, Motoko; Nakagata, Naomi; Evans, Sylvia M.; Graf, Daniel; Economides, Aris; Haraguchi, Ryuma; Moon, Anne M.; Yamada, Gen

    2012-01-01

    Sirenomelia, also known as mermaid syndrome, is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Most affected infants are stillborn, and the few born alive rarely survive beyond the neonatal period. Despite the many clinical studies of sirenomelia in humans, little is known about the pathogenic developmental mechanisms that cause the complex array of pheno...

  8. Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia.

    Directory of Open Access Journals (Sweden)

    Kentaro Suzuki

    Full Text Available Sirenomelia, also known as mermaid syndrome, is a developmental malformation of the caudal body characterized by leg fusion and associated anomalies of pelvic/urogenital organs including bladder, kidney, rectum and external genitalia. Most affected infants are stillborn, and the few born alive rarely survive beyond the neonatal period. Despite the many clinical studies of sirenomelia in humans, little is known about the pathogenic developmental mechanisms that cause the complex array of phenotypes observed. Here, we provide new evidences that reduced BMP (Bone Morphogenetic Protein signaling disrupts caudal body formation in mice and phenocopies sirenomelia. Bmp4 is strongly expressed in the developing caudal body structures including the peri-cloacal region and hindlimb field. In order to address the function of Bmp4 in caudal body formation, we utilized a conditional Bmp4 mouse allele (Bmp4(flox/flox and the Isl1 (Islet1-Cre mouse line. Isl1-Cre is expressed in the peri-cloacal region and the developing hindimb field. Isl1Cre;Bmp4(flox/flox conditional mutant mice displayed sirenomelia phenotypes including hindlimb fusion and pelvic/urogenital organ dysgenesis. Genetic lineage analyses indicate that Isl1-expressing cells contribute to both the aPCM (anterior Peri-Cloacal Mesenchyme and the hindlimb bud. We show Bmp4 is essential for the aPCM formation independently with Shh signaling. Furthermore, we show Bmp4 is a major BMP ligand for caudal body formation as shown by compound genetic analyses of Bmp4 and Bmp7. Taken together, this study reveals coordinated development of caudal body structures including pelvic/urogenital organs and hindlimb orchestrated by BMP signaling in Isl1-expressing cells. Our study offers new insights into the pathogenesis of sirenomelia.

  9. Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des EPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks:From Contamination Analysis to the Collective Whistle-Blowing Process Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    Directory of Open Access Journals (Sweden)

    Alain Garrigou

    2008-05-01

    Full Text Available L’objectif de cet article est de présenter des résultats récents d’une recherche/action en ergotoxicologie concernant les risques liés à l’usage des produits phytosanitaires. Cette recherche propose une double articulation : la première entre des résultats issus d’analyses en situations de travail portant sur la contamination externe des viticulteurs et des résultats issus de tests en laboratoire portant sur la perméation des combinaisons. La seconde articulation concerne le lien entre l’ensemble des résultats cités ci-dessus et une analyse des failles techniques et organisationnelles de la conception et des processus de certification des EPI (équipements de protection individuelle. Sur ces bases, la question des EPI sera alors abordée sous l’angle d’un transfert de technologie entre des milieux industriels et les réalités des situations agricoles. Ceci conduit à un diagnostic très préoccupant en matière d’efficacité réelle des combinaisons. Nous aborderons aussi les questions des responsabilités juridiques soulevées par de tels manquements. Enfin, nous détaillerons le rôle de whistler blower (Vaugan, 1996 que nous avons décidé de jouer ainsi que le processus d’alerte que nous avons construit afin de poser autrement le problème des EPI et intéresser l’ensemble des acteurs.This paper presents the results of an ergotoxicologic study on the effectiveness, in real-life conditions, of the protective suits recommended by preventionists. The arguments presented in the paper are based on the Pestexpo study conducted by Isabelle Baldi (Baldi et al. (2002 and Baldi et al. (2006, which involved analyzing the exposure of vineyard workers to plant protection products by using an ergo-toxicologic approach. The point is to identify different types of exposure by taking into account the characteristics of the actual work (as opposed to what the operators are supposed to be doing as an outcome of personal

  10. Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks. From Contamination Analysis to the Collective Whistle-Blowing Process Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des ÉPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    Directory of Open Access Journals (Sweden)

    Alain Garrigou

    2008-05-01

    processus de certification des EPI (équipements de protection individuelle. Sur ces bases, la question des EPI sera alors abordée sous l’angle d’un transfert de technologie entre des milieux industriels et les réalités des situations agricoles. Ceci conduit à un diagnostic très préoccupant en matière d’efficacité réelle des combinaisons. Nous aborderons aussi les questions des responsabilités juridiques soulevées par de tels manquements. Enfin, nous détaillerons le rôle de whistler blower (Vaugan, 1996 que nous avons décidé de jouer ainsi que le processus d’alerte que nous avons construit afin de poser autrement le problème des EPI et intéresser l’ensemble des acteurs.El objetivo de este artículo es presentar los resultados recientes de una investigación/acción en ergotoxicología sobre los riesgos relacionados con el uso de productos fitosanitarios. Esta investigación propone una doble articulación : la primera, entre resultados que emergen de análisis realizados en situaciones de trabajo sobre la contaminación externa de los viticultores y resultados provenientes de tests de laboratorio sobre la permeabilidad de la vestimenta de protección. La segunda articulación trata de la relación entre el conjunto de resultados ya citados y un análisis de los fallos técnicos y organizacionales del diseño y de los procesos de certificación de los EPI (equipos de protección individual. La problemática de los EPI será abordada desde el ángulo de una transferencia de tecnología entre los medios industriales y las realidades de las situaciones agrícolas. Esto conduce a un diagnóstico muy preocupante sobre la eficacia real de las vestimentas de protección. Abordaremos también las preguntas sobre la responsabilidad jurídica que emergen de estas carencias. Finalmente, explicaremos el rol de whistler blower (Vaugan, 1996 que decidimos jugar y el proceso de alerta que construimos para plantear de otra manera el problema de los EPI y hacer

  11. What is new in the local approach of limb sarcomas and desmoid tumours?; Actualisation de la strategie therapeutique locoregionale dans les sarcomes des tissus mous et les tumeurs desmoides des membres

    Energy Technology Data Exchange (ETDEWEB)

    Bonvalot, S.; Rimareix, F.; Paumier, A.; Roberti, E.; Bouzaiene, H.; Le Pechoux, C. [Comite sarcomes, departement de chirurgie, institut Gustave-Roussy, 94 - Villejuif (France)

    2010-10-15

    The treatment of soft tissue sarcomas of limbs should be discussed within an experienced multimodality team. Surgical resection remains the cornerstone of therapy for localized disease and achieves a five years overall survival around 75% and a local recurrence rate as low as 10% in the best series. In complex cases, neo-adjuvant treatments may be used such as systemic chemotherapy, isolated limb perfusion, or radiotherapy to achieve an optimal conservative approach. Molecular genetics of sarcomas and quality of margins are essential to guide diagnosis and therapeutic selection. In case of marginal or incomplete resection, a new enlarged surgical resection should always be discussed before administration of any adjuvant treatments. Many retrospective studies and two randomized studies (one of adjuvant brachytherapy and one of external beam radiotherapy) have shown that adjuvant radiotherapy after complete surgery significantly reduces the risk of local recurrence in extremity soft tissue sarcomas. A randomized study has compared pre- to postoperative radiotherapy. The results in terms of local control are similar in both arms. The risk of surgical complications is higher in the preoperative arm and the risk of late sequelae is higher in the postoperative arm. A randomized study within the French sarcoma group is ongoing evaluating the omission of postoperative radiotherapy in favourable cases. Presently, the role of systematic first-line invasive treatment (including surgery and/or radiotherapy) of desmoids is debated. It is becoming evident that up to 50% of patients with desmoids benefit from a front-line non-aggressive policy, because growth arrest is a common feature of this disease. Additional study of the molecular determinants of desmoid behaviour is needed to guide treatment. (authors)

  12. Place of the radiotherapy in the care of the extra-mammary Paget disease; Place de la radiotherapie dans la prise en charge therapeutique de la maladie de Paget extramammaire

    Energy Technology Data Exchange (ETDEWEB)

    Yanes, B.; Notter, M.; Dragusanu, D. [Hopital Neuchatelois, La Chaux-De-Fonds (Switzerland)

    2007-11-15

    The cutaneous tolerance of the radiotherapy was satisfactory and the treatment took place continuously at all the patient's. A patient is always in situation of clinical forgiveness, 3 years after the irradiation and another waits after two years, and finally a extra-mammary disease of Paget did it again 1 year after the irradiation and was treated by surgery of correction. It is still too much early to estimate the last two patients, treated in 2007. (N.C.)

  13. What is the future of the children after therapeutic irradiation of their mother during their pregnancy?; Que deviennent les enfants dont les meres ont ete irradiees a visee therapeutique pendant leur grossesse?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2008-12-15

    Abnormalities in children exposed to radiation during gestation occur more specially when the mother irradiation is made between the third and the eleventh week of pregnancy. However a case is reported through a child irradiated in utero and whom development is normal. So, more than a proposition of abortion to the parents it would be convenient to propose a long term surveillance by pediatricians and register these cases in a national data base, this rounding up of knowledge will allow to consolidate the advices that could be given to the parents on taking any precaution in this particularly difficult context. (N.C.)

  14. New procedures to measure synthase and phosphatase activities of bis-phosphoglycerate mutase. Interest for development of therapeutic drugs; Nouveaux procedes pour mesurer les activites synthase et phosphatase de la bisphosphoglycerate mutase. Interet pour le developpement de drogues therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Ravel, P.; Garel, M.C. [Hopital Henri-Mondor, 94 - Creteil (France); Toullec, D. [Laboratoire Glaxo Wellcome, 91- Les Ulis (France)

    1997-12-31

    In red blood cells, a modulation of the level of the allosteric effector of hemoglobin, 2,3-diphosphoglycerate (2,3-DPG) would have implications in the treatment of ischemia and sickle cell anemia. Its concentrations is determined by the relative activities of the synthase and phosphatase reactions of the multifunctional bis-phosphoglycerate mutase (BPGM). In this report we develop first a more direct synthase assay which uses glyceraldehyde phosphate to suppress the aldolase and triose phosphate isomerase reactions. Secondly we propose a radioactive phosphatase assay coupled to chromatographic separation and identification of the reaction products by paper electrophoresis. Such identification of these products allows us to show that the multifunctional BPGM expresses its mutase instead of its phosphatase activity in conditions of competition between the 3-phosphoglycerate and the 2-phospho-glycolate activator in the phosphatase reaction. These two more precise procedures could be used to study the effects of substrate and cofactor analogues regarding potential therapeutic approaches and could be used for clinical analyses to detect deficiency of BPGM. (author)

  15. Lymphoscintigraphy in the management of lymphoedemas and their health costs reimbursement in Belgium; La lymphoscintigraphie dans la prise en charge therapeutique des oedemes des membres par les soins de sante en Belgique

    Energy Technology Data Exchange (ETDEWEB)

    Bourgeois, P. [Service de medecine nucleaire, institut Jules-Bordet, universite Libre de Bruxelles, Bruxelles (Belgium); Belgrado, J.P. [Institut des sciences de la motricite -anciennement institut superieur d' education physique et de kinesitherapie, universite Libre de Bruxelles (Belgium); Aerens, C. [Service de kinesitherapie, institut Jules-Bordet, universite Libre de Bruxelles (Belgium)

    2010-12-15

    Limb edemas of lymphatic origin, either primary, or secondary, represent a chronic disease sometimes heavy to bear by patients who suffer from them. These lymphoedemas imply specific care by physical therapists trained to the use of different therapeutic approaches. Until a few years, only the treatments of secondary lymphoedemas after radiotherapy and/or complete nodal dissection for cancer were reimbursed by the national health insurance system in Belgium. The introduction of the primary congenital lymphoedemas as a disease also reimbursed raised several problems and led to a redefinition of these situations and of their cares. The definition and classification of the lymphoedemas in view of the reimbursement of their treatments by the national health insurance system are now officially based (not only on the sole clinical history but) mainly on their clinical severity and/or also on the result of their lympho-scintigraphic investigation (according to a methodological protocol and to diagnostic criteria adopted at the national level). The reimbursements of the treatments by the physical therapists were also adapted and improved. The lympho-scintigraphic investigations of the limb edemas became so essential in the management of the lymphedematous situations and in the reimbursement of their physical treatments in Belgium. (authors)

  16. Amélioration de l’efficacité de l’absorption du rayonnement solaire photovoltaïque par utilisation des nanostructures.

    OpenAIRE

    TRAORE Soumaïla, Amara

    2014-01-01

    L’absorption complète de la lumière solaire dans le silicium cristallin nécessite une épaisseur de matériau de l’ordre de 500 microns, une large fraction de la lumière est perdue par transmission lorsque l’épaisseur de matériau diminue en deçà de 10 microns. Les cellules photovoltaïques en couches minces (cellules de 2ème génération) tentent de contourner les difficultés rencontrées par cette traditionnelle technologie en minimisant la quantité de matière active semi-conductrice par kWh insta...

  17. Modélisation Bond Graphs en vue de l'efficacité énergétique du bâtiment

    OpenAIRE

    Abdelatif, Merabtine

    2012-01-01

    Our works focus on the setting of reliable tools able to analyze the interaction between the building envelope and HVAC systems. The developed approach is based on Bond Graphs methodology, a graphical modeling language which is particularly suitable for energy exchanges. A numerical model gathering, under the same simulation environment, sub-models representing the building envelope, the solar gains, the floor heating, the chilled ceiling and the ventilation system, is developed in order to p...

  18. Etude comparative relative à l’efficacité énergétique de deux appartements situés à Béchar, Algérie

    OpenAIRE

    BENOUDJAFER, I.; Ghomari, F.; Mokhtari, A.

    2012-01-01

    The aim of this paper is the Comparative Study on Energy Efficiency of two apartments which is located in Bechar (Algeria). In this regard, simulations were performed using the software simulation of thermal behavior in dynamic ‘TRNSYS 16’ with the numerical model type 56. This project is the introduction of insulating materials in buildings to improve thermal comfort and reduce energy consumption. Various solutions have been proposed or variants, which can make a relevant choice...

  19. Neoplasms radiosensitivity: how to increase the efficiency of radiotherapy. Radiosensibilite des tumeurs: comment augmenter l'efficacite de la radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Calais, G. (Hopital Bretonneau, 37 - Tours (FR))

    1991-12-01

    The hypoxia in the neoplasms is a radioresistance factor. This article is about the methods able to reduce the hypoxia in tumors: use of hyperbaric oxygen, radiosensitizers (as metronidazole), hyperthermia and modification of oxygen release in the tissues in modifying the blood flow and in reducing the hemoglobin affinity for oxygen.

  20. Evaluation experimentale de l'efficacite des gants de protection contre les nanoparticules de dioxyde de titane dans des conditions de travail

    Science.gov (United States)

    Vinches, Ludwig

    Manufactured titanium dioxide nanoparticles (nTiO2) enter into the formulation of several commercial products including cosmetics, paints, varnishes or food. An increasing number of people will be exposed to nanoparticles (NP), in particular, scientists during their research and workers in companies. As such, they are an emerging source of hazard. Indeed, an increasing number of studies are warning against their likely harmful effects on health. The International Agency for Research against Cancer has classified nTiO2 as being possibly carcinogenic to humans. Furthermore some studies have shown that the skin is not an impervious membrane to the NP and that NP penetration is possible when the skin is injured by abrasion, after repeated flexions or even intact. Therefore, dermal protection will be necessary in order to thoroughly protect NP users. Based upon the precautionary principle, gloves should be used as protection against chemicals. However, to the best of our knowledge, no study on their resistance towards NP has been conducted. In this study, the performance of protective gloves was evaluated with respect to nTiO2 solutions and powders, under conditions simulating occupational use. Mechanical deformations, simulating those produced by hand flexing, were applied to nitrile and butyl rubber and latex samples that were in contact with nTiO2 in water, in propylene glycol or in powder form. nTiO 2 penetration through the protective gloves was determined after deformations of the materials. Following these results, the physicochemical and mechanical phenomena that facilitate the penetration of nTiO2 were identified and studied. It was shown that mechanical deformations caused both damage to the sample surface but also a change in the degree of crystallinity of the glove material. Strain energy was also measured. It decreased significantly in presence and absence of nTiO2, indicating a weakening of the polymer chains. A qualitative study showed that repetitive deformations also lead to a decrease in the size of the agglomerates that were contained in the nTiO2 powder. Glove materials that were in contact with colloidal solutions produced a swelling phenomenon. Finally, measurements of the elongation of glove samples immersed in colloidal solutions were used to determine diffusion coefficients across the materials. The transport of the nanoparticles was driven by that of the carrier liquid (water or propylene glycol). Given the carrier solutions and nanoparticles could be transported through the gloves, exposure to skin could occur.

  1. Optimisation de la qualité et de l'efficacité des dispositifs médicaux de perfusion simple et complexe

    OpenAIRE

    Lannoy, Damien

    2010-01-01

    Intravenous infusion, whether used continuously or intermittently, is a common feature in healthcare, although not without risk. Various medical devices can be used to administer the infusion, sometimes simultaneously, of several active substances . These devices, because of their characteristics, may generate more or less significant variations in drug mass flow rate, which is the amount of drug delivered per unit of time to the patient. The first part of this work on these medical devices f...

  2. Nouveaux critères pour juger de l'efficacité d'un fourneau à la combustion du charbon de bois

    OpenAIRE

    Ndaysenga, M.; Croiset, G.; Cordier, Y.

    1994-01-01

    New Criteria to Judge Stove Efficiency in the Charcoal Combustion. The water boil test efficiency for choosing the most economic stove in combustion is estimated on the basis of four stoves. In addition to the heating and boiling energy usually considered as selection criterion, other criteria such as the boiling time and the combustion rate have been taken to indicate efficiency. Strangely, it appeared that the stove which maintains water at its boiling point for a long time and has the lowe...

  3. Nouveaux critères pour juger de l'efficacité d'un fourneau à la combustion du charbon de bois

    Directory of Open Access Journals (Sweden)

    Ndaysenga, M.

    1994-01-01

    Full Text Available New Criteria to Judge Stove Efficiency in the Charcoal Combustion. The water boil test efficiency for choosing the most economic stove in combustion is estimated on the basis of four stoves. In addition to the heating and boiling energy usually considered as selection criterion, other criteria such as the boiling time and the combustion rate have been taken to indicate efficiency. Strangely, it appeared that the stove which maintains water at its boiling point for a long time and has the lowest combustion rate doesn 't valorize fuel energy efficiently if you only keep to the heating and boiling energy. The cooking test made it possible to explain that apparent contradiction : the fuel energy fraction which doesn't enter in the calculation of the heating and boiling energy isn't really lost. A low combustion rate associated with a long boiling time proved to be the best criteria of choosing the most economic stove in fuel. Therefore, the only water boil test doesn't make it possible to identify the most economically efficient stove. Resorting to the cooking test is compelling.

  4. Energy sources consumption: end uses, efficiency and productivity; La consommation des sources d'energie: utilisations finales, efficacite et productivite

    Energy Technology Data Exchange (ETDEWEB)

    Martin, J.M. [Institut d' Economie et de Politique de l' Energie (CNRS- UPMF), 38 - Grenoble (France)

    2005-07-01

    This document analyzes the impact of the choices made by all actors, from the energy producers to the process and infrastructure designers and the end users, in the evolution of energy consumptions. Some very little improvements made in the energy efficiency of appliances can become equivalent to the production of several oil fields or power plants at the world scale. More efficient energy uses will not replace the additional productions but they must be considered together to be compared. The energy files are first analyzed as a whole in order to show the hidden field of energy choices. In this framework, users, designers and fitters have to face very different choices because they consider efficiency improvements under different aspects: scientifical, technical, economical and social (public information and habits). These differences in efficiency uses have a time and spatial impact on the growth of energy consumption. The economical and social factors influence the collective way to consume energy and are expressed by the energy intensity of the economic activity. The last part of this document analyzes the influence of this notion on the world energy consumption scenarios at the 2050 prospects. (J.S.)

  5. Méthodes d’optimisation dynamique de systèmes à plusieurs états pour l'efficacité énergétique automobile

    OpenAIRE

    Maamria, Djamaleddine

    2015-01-01

    La gestion énergétique (EMS) pour véhicules hybrides a pour objectif de déterminer la répartition de puissance entre les différentes sources d'énergie de manière à minimiser la consommation de carburant et/ou les émissions polluantes. L'objectif de cette thèse est de développer un EMS en prenant en compte des températures internes (la température du moteur et/ou la température du système de post-traitement). Dans une première partie et en utilisant une connaissance préalable du cycle de condu...

  6. Comparaison de l'efficacité de divers pré-traitement de spectres pour la discrimination du blé et des mauvaises herbes au champ

    OpenAIRE

    Hadoux, X.; Gorretta, N.; Roger, J.M.; Bendoula, R.; Rabatel, G.

    2014-01-01

    The optimal processing of spectral data often requires specific pre-treatments. In the context of spectral discrimination, results can be greatly improved using the relevant pre-treatment. Most importantly, the pre-treatment must be suited to the nuisance variability that has to be removed. This study focuses on discrimination of weed and wheat using spectra acquired in outdoor conditions with uncontrolled lighting and leaf orientations. Both vegetation spectra are highly similar, and d...

  7. Collaboration des équipements du réseau domestique pour une meilleure efficacité énergétique globale

    OpenAIRE

    Yan, Han

    2014-01-01

    Au cours des dernières années, la révolution numérique a continué sa progression. Les technologies de l'information et des communications (TIC) ont totalement changé la vie quotidienne des gens à leur domicile (concept de « maison numérique »). Pendant ce temps, non seulement le volume des émissions de CO2 produit par les TIC, ce qu'on appelle l'empreinte carbone, est sans cesse en croissance mais elle s'accompagne également d'une hausse du prix de l'électricité, augmentant fortement la part ...

  8. Evaluation au moyen d'un examen par des pairs de l'efficacite d'un programme reglementaire de surete radiologique. Rapport interimaire pour observations

    International Nuclear Information System (INIS)

    This document covers assessment of those aspects of a radiation protection and safety infrastructure that are implemented by the Regulatory Authority for radiation sources and practices using such sources and necessarily includes those ancillary technical services, such as dosimetry services, which directly affect the ability of the Regulatory Authority to discharge its responsibilities. The focus of the guidance in this TECDOC is on assessment of a regulatory programme intended to implement the BSS. The BSS address transportation and waste safety mainly by reference to other IAEA documents. When conducting an assessment, the Review Team members should be aware of the latest IAEA documents (or similar national documents) concerning transportation and waste safety and, if appropriate, nuclear safety, and take them into account to the extent applicable when assessing the effectiveness of the regulatory programme governing radiation protection and safety of radiation source practices in a particular State

  9. Differentiation, international equity and efficiency in the fight against the global climatic change; Differenciation, equite internationale et efficacite dans la lutte contre le changement climatique global

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, O.; Criqui, P.; Viguier, L. [Institut d' Economie et de Politique de l' Energie - IEPE-CNRS/ Universite Pierre Mendes-France, 38 - Grenoble (France); Trommetter, M. [Institut National de Recherches Agronomiques (INRA), 38 - Grenoble (France)

    1998-05-01

    The first difficulty to get over in the international negotiation on the climatic change, has been and still remain the distribution of the efforts and the research of the equity in the objective determination. This paper analyzes the possible consequences of the negotiable emission licenses in terms of efficiency and equity. The first part is a review of the different charts of the objectives differentiation discussed or proposed in the international negotiation process on the greenhouse effect. It aims to find a bond between the the charts and the equity. The second part deals with the programs cost and their relative efficiency, taking into account the marginal cost curves. (A.L.B.)

  10. Presentation of the national program for the improvement of the energy efficiency; Presentation du programme national d'amelioration de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    This paper is the presentation of the energy mastership national program. It deals with the actions leading to the development of the enterprises and household demand, the increase of the actions in favor of the energy, the actions in the transportation sector, the actions in the habitat domain, the mastership of the energy consumption for the industrial and service sector industries, the renewable energies development, the ADEME devices. (A.L.B.)

  11. Observateur et contrôle optimal : améliorer l'efficacité de la conduite automobile avec Kalman et Pontryagin

    OpenAIRE

    Sebesta, Kenneth

    2010-01-01

    The PhD presents a combined approach to improving individual car efficiency. An optimal observer, the Extended Kalman Filter, is used to create an efficiency model for the car. Particular attention was paid to handling the asynchronous and redundant nature of the measurement data. A low-cost sensor suite developed to measure data is described. This sensor suite was installed on multiple vehicles to good success. It employsan accelerometer, gps, fuel injector timer, and Vss input to measure al...

  12. Lutte chimique contre le gui (Viscum album L.). Penetration, transport, efficacite de deux herbicides phloeme-mobiles (2,4-DB et glyphosate)

    OpenAIRE

    Baillon, F.; Chamel, A; Fer, A.; Frochot, Henri

    1988-01-01

    Une méthode de lutte chimique contre le gui des feuillus (Viscum album album, BALL) a été envisagée à l’aide de deux herbicides phloème-mobiles (2,4-DB et glyphosate) appliqués sur les feuilles du parasite. Avant leur distribution dans le parasite, les herbicides doivent pénétrer à travers la cuticule des feuilles. L’influence de plusieurs paramètres (concentration, pH, cires cuticulaires solubles) sur la fixation et la perméabilité cuticulaires des deux herbicides a été étudiée in vitro...

  13. Efficiency of scintigraphy for leakage diagnosis: clinical reports; Efficacite de la scintigraphie dans le diagnostic de breches: illustration a l'aide de cas cliniques

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Ph.; Jeandot, R.; Cazeau, A.L.; Guyot, M.; Basse-Cathalinat, B. [Hopital Pellegrin, 33 - Bordeaux (France)

    2002-09-01

    In many clinical circumstances (cranial traumatisms, renal dialysis, renal graft complications, or reconstructive surgery), leakage diagnosis is often difficult to prove for clinician. In this way, interest of scintigraphic methods is not often well known. Literature review shows many papers concerning leakage diagnosis but essentially in neurology, digestive reconstructions or renal transplantation surgery. Nevertheless, through our own experience, we show particular cases, for example uro-colic fistula, where isotopic method can be of great interest to clarify complex clinical situations. So, close collaboration is necessary between clinician and nuclear medicine who will adapt methodology to diagnose chidden leakage. (authors)

  14. Energy efficiency at the St-Guillaume cheese factory, a profitable choice; L'efficacite energetique a la fromagerie St-Guillaume, un choix profitable

    Energy Technology Data Exchange (ETDEWEB)

    Tremblay, P.; La Roche, R. [Fromagerie St-Guillaume, Saint-Guillaume, PQ (Canada)

    2009-12-15

    The Co-op Agrilait de St-Guillaume is located at near Drummondville, Quebec. The facility employs 160 people to produce 3 million kilograms of cheese annually. In addition, 21 million litres of whey are produced. This sub-product of cheese is turned into powder to make ice cream, protein shakes, energy drinks, and feed for animals. The cost of transforming whey had gone up over the last five years, which also cut into the operating budget. Whey transformation also consumed large amounts of well water. In order to address these challenges, the energy consumption of the facility was evaluated in an effort to lower the energy costs by 30 per cent, lower water consumption and reduce water pollution. The study identified and measured the energy consumption for each activity related to the whey transformation process. The equipment and procedures used in the facility were subsequently modernized and the air quality in the facility was also improved. The improvement in whey transformation rendered the facility profitable again. The project was financed by capital loans over a ten year period, and the money saved during the first year was over $400,000. The money saved over the next 10 years will be more than 2 million dollars. 5 figs.

  15. L'ammoniac NH3 une clé pour comprendre l'efficacité des supergranules d'urée en riziculture irriguée

    OpenAIRE

    Gaudin, Rémi

    1988-01-01

    7 International audience Une petite bougie en céramique poreuse placée au contact d'un supergranule d'urée de 2 g et utilisée comme préleveur, a permis de montrer que quatre jours après le placement de l'engrais azoté, il reste dans la solution du sol 180 mg/L d'azote uréique contre 4000 mg/L d'azote ammoniacal. Cette hydrolyse très rapide se traduit par une augmentation du pH qui atteint presque le pKa de l'ammoniaque (9,25). L'analyse de l'évolution de la concentration en azote ammoni...

  16. HEPATOSTAT : EVALUATION DE L'EFFICACITE ET LA TOLERANCE DE LA BITHERAPIE CHEZ LES PATIENTS MAROCAINS TRAITES DE L'HEPATITE C

    OpenAIRE

    El Malki, Ghassan; Ahid, Samir

    2013-01-01

    National audience Title: Evaluation of the efficacy and safety of bitherapy on Moroccan patients treated from hepatitis C. Dr ghassan Elmalki 1, Pr Samir Ahid 1, and Pr Yahia Cherrahn1 1 Research Team of Pharmacoepidemiology & Pharmacoeconomics. Laboratory of Pharmacology - Toxicology, Faculty of Medecine and Pharmacy, Rabat, Rabat, Morocco. Background: In Morocco studies estimate a prevalence of HCV to 3,5% for the whole population, and 5% for the age group between 45 and 75 years. Accord...

  17. Faut-il réfléchir pour être performant en groupe ?: les conditions de l’efficacité de la réflexivité

    OpenAIRE

    Facchin, Stéphanie; Tschan, Franziska

    2009-01-01

    In this dissertation I concentrate on some of the boundary conditions of reflexivity in teams. Research has shown that reflexivity (collectively reflecting on the teams’ objectives, strategies, and processes and adapting them accordingly) can enhance team performance and innovation. This effect, however, may have boundary conditions. Indeed, prior research has shown that the positive effects of reflexivity were often not straightforward, but depended on other variables. Given the many variabl...

  18. Marchés et comportements des acteurs dans une filière industrielle : efficacité et équité

    OpenAIRE

    Michel Hollard; Daniel Llerena

    2004-01-01

    [fre] Cet article concerne les marchés auxquels sont confrontées les entreprises industrielles, qui sont organisées en filières. Dans chacune des configurations analysées, deux types de décision doivent être pris par les entreprises : les premières concernent la détermination des quantités produites, les secondes le partage de la valeur ajoutée entre l'entreprise amont et l'entreprise aval. La méthode d'analyse utilisée est celle de l'économie expérimentale. Les résultats obtenus ne correspon...

  19. The fight against the greenhouse effect. Equity and efficiency; La lutte contre l'effet de serre. Equite et efficacite

    Energy Technology Data Exchange (ETDEWEB)

    Vallee, A. [Paris-12 Univ., 94 - Creteil (France)

    2003-07-01

    The author discusses the definition of an equitable division rule of the global effort of greenhouse gases emissions decrease, the research of the economic efficiency, the flexibility mechanisms and the emissions trading. (A.L.B.)

  20. Et si l'efficacité de la lutte contre les incendies jouait comme une incitation aux comportements les plus risqués.

    OpenAIRE

    Napoléone, C.; Jappiot, M.

    2008-01-01

    / L'efficience des moyens de défense contre les incendies, eu égard à la protection des habitations et des habitants, est susceptible de faire oublier la relation qui existe entre la construction en forêt et le risque d'incendie. L'observation des préférences individuelles exprimées sur le marché immobilier montre en effet un déficit de conscience individuelle du risque: lorsqu'un individu achète une villa périurbaine, il tend à privilégier l'ambiance forestière, quelle que soit l'exposition ...

  1. A medium size hotel in Toronto displays the advantages of energy efficiency; Un hotel de taille moyenne de Toronto demontre les avantages de l'efficacite energetique

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2000-09-01

    The Four Points Hotel is located in Toronto and possesses 296 rooms. The annual budget devoted to energy costs was 460 500 dollars. In 1998, the hotel management team met with an energy management team to devise an energy efficiency plan. Approximately one year later, renovation and upgrading work began with the help of the Energy Innovators Initiative from the Office of Energy Efficiency, Natural Resources Canada. The electricity bill represented 73 per cent of the annual energy budget of the hotel. Therefore, lighting seemed like a logical starting point. Each of the 2 700 lamps in the building was replaced with energy efficient lighting. Lighting levels were maintained, and were even improved, as was the case in the interior parking garage. The heating boiler was replaced by an energy efficient one, on the advice of the energy efficiency team. Five heating, ventilation, and air conditioning systems located on the roof, were replaced by energy efficient systems which optimized the ventilation in the hotel. Energy costs were down, as well as the maintenance costs, and the reliability was greatly improved. Energy management is centrally controlled by a computer system called LONWorks. The customers have the possibility of setting their room thermostat between 19 and 24 Celsius. The biggest advantage of the system is the wireless communication between the main building and the parking garage. The parking garage therefore benefits from the same control system without the additional costs associated with the installation of cables. At the start, the expected energy savings were 20 per cent. The management team discovered that the energy savings were more in the order of 35 per cent. In other words, it means 653,000 kWh of electricity and 878,530 hours in gas savings. The first seven months after the completion of the work yielded 52,680 dollars in savings. The hotel business represents a sector where energy efficiency yields big savings, in addition to helping the country meet its goals in terms of climate change. Additional information on the Energy Innovators Initiative is available from Natural Resources Canada.

  2. Design of a software for gamma detector efficiency; Realisation d'un outil de simulation d'efficacite gamma

    Energy Technology Data Exchange (ETDEWEB)

    Lopez, G. [EAMEA Base Navale, 50 - Cherbourg (France)

    2011-07-01

    Gamma spectroscopy with highly-pure-germanium detector is one of the most used method for qualitative and quantitative analysis of samples. Nevertheless Gamma spectroscopy results require to be corrected, first for taking into account the self-shielding effect that represents the absorption of the photons by the sample itself and secondly for correcting the fact that 2 photons emitted simultaneously with energy E{sub 1} and E{sub 2} are likely to be simultaneously detected and then counted as a single photon with an energy E{sub 1}+E{sub 2}. This effect is called gamma-gamma coincidence. A software has been designed to simulate both effect and produce correcting factors in the case of cylindrical geometries. This software has been validated on Americium 241 for the self-shielding effect and on Cesium 134 for gamma-gamma coincidence. (A.C.)

  3. Penser la gestion documentaire pour la direction juridique d'une grande entreprise : assurer l'efficacité d'aujourd'hui et garantir les risques de demain

    OpenAIRE

    Thomas, Magali

    2011-01-01

    Au sein des grandes entreprises, la gestion des risques et de la conformité sont de plus en plus au cour des préoccupations des juristes comme des professionnels de l'information. L'analyse des besoins des juristes en matière de gestion documentaire, à partir de celles de l'activité et des missions d'une direction juridique par le prisme de l'information, révèle qu'une démarche de records management peut répondre, de par ses caractéristiques et ses objectifs, à une bonne partie de ces besoins...

  4. Amélioration de l’efficacité de la programmation opératoire au sein des établissements de soins de santé

    OpenAIRE

    Hanset, Arnauld

    2010-01-01

    The aim of this thesis is to help in the management of the operating theatre in order to improve its functionality. Our research focuses on the daily scheduling of the surgical acts in an operating theatre. According to the researchers who focus their study on dealing with operating theatre problems, the operating theatre is also known to be one of the most expensive items among all sectors of a hospital. Considering the importance of improving the efficiency of the operating theatre, increas...

  5. Treatment of patients with a congenital transversal vaginal septum or a partial aplasia of the vagina. The vaginal pull-through versus the push-through technique.

    NARCIS (Netherlands)

    Bijsterveldt, C.D. van; Willemsen, W.N.P.

    2009-01-01

    STUDY OBJECTIVE: The aim of this study is to describe the different modalities of congenital obstructing vaginal malformations and the evaluation of techniques to solve the problem. DESIGN: A retrospective study. SETTING: The University Hospital Nijmegen, the Netherlands. PARTICIPANTS: The medical r

  6. The study on the preparation of rhIL-6 and its effects on recovery of mice from radiation-induced hematopoietic aplasia

    International Nuclear Information System (INIS)

    The E coil highly expressing rhIL-6 constructed by our department was fermented and rhIL-6 products were extracted and purified. The specific activity of the purified rhIL-6 products reached 4.83 x 108 IU/mg. The rhIL-6 products were used to treat BALB/c mice injured by 60Co irradiation for six days (2 μg/big/each). The results showed that the bleeding time, coagulation time and prothrombin time of the rhIL-6 treatment group were significantly shorter than those of the control group (P<0.01), the platelet count and WBC increased by 130% and 165% in the treatment group as compared with the control, the numbers of CFU-Mix cultured in vitro and CFU-s in spleen were significantly higher than those in the control group (P<0.01). These results suggest that rhIL-6 exerts beneficial effects on the recovery of mice from radiation-induced injuries of hematopoietic stem/progenitor cells, and thus helps recovery from radiation injury of bone marrow and hematopoietic function. (17 refs., 4 figs., 5 tabs.)

  7. Autologous cell therapy as a new approach to treatment of radiation-induced bone marrow aplasia: preliminary study in a baboon model

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Drouet, M. [Radiohematology Unit, Centre de Recherches du Service de Sante des Armees, La Tronche CEDEX (France)

    2002-07-01

    The sparing of viable hematopoietic stem and progenitor cells located in underexposed bone marrow territories associated with the relative radioresistance of certain stem cell populations is the rationale for autologous cell therapy consisting of ex vivo expansion of residual cells after collection postirradiation. The feasibility of this treatment mainly depends on time constraints and hematopoietic cell threshold. We showed in this study that in the absence of early-acting mobilizing agent administration, subliminar amounts of CD34{sup +} cells can be collected (1 x 10{sup 6} CD34{sup +} cells/100 mL bone marrow or for 1 L apheresis) from 6-Gy {gamma} globally irradiated baboons. Residual CD34{sup +} cells were successfully expanded in serum-free medium in the presence of antiapoptotic cytokine combination (stem cell factor + FLT-3 ligand + thrombopoietin + interleukin 3, 50 ng/mL each, i.e., 4F): K{sub CD34{sup +}} = x2.8 and x13.7 (n=2). Moreover, we demonstrated the short-term neutrophil engraftment potential of a low-size mixed expanded graft (1.5 x 10{sup 6} final CD34{sup +}cells/kg) issued from the coculture of unirradiated (20%) and 2.5-Gy in vitro irradiated (80%) CD34{sup +} cells on an allogeneic stromal cell layer in the presence of 4F. Further preclinical research needs to be performed to clearly establish this therapeutic approach that could be optimized by the early administration of antiapoptotic cytokines. (author)

  8. Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection

    Science.gov (United States)

    Sreedharanunni, S; Sachdeva, MUS; Prakash, G; Das, R

    2016-01-01

    The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings. PMID:26515990

  9. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  10. Impact of additional cervical dedicated {sup 18}FDG-PET-CT on the management of head and neck squamous cell carcinoma; Impact therapeutique de l'acquisition cervicale dediee en [{sup 18}F]-FDG-TEP-TDM sur la prise en charge des carcinomes epidermoides de la tete et du cou

    Energy Technology Data Exchange (ETDEWEB)

    Queneau, M.; Tourdias, T.; Guyot, M.; Allard, M.; Fernandez, P. [CHU Pellegrin-Tripode, Service de Medecine Nucleaire, 33 - Bordeaux (France); Houliat, H. [CHU Pellegrin-Tripode, Service d' Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale du Pr Bebear, 33 - Bordeaux (France)

    2008-09-15

    Aim of the study: To investigate the therapeutic impact of additional cervical dedicated {sup 18}F.D.G.-PET-CT on the management of head and neck squamous cell carcinoma (H.N.S.C.C.). Materials and methods: Thirty patients with H.N.S.C.C. underwent a [{sup 18}F]-F.D.G.-PET-CT standard, whole-body scan completed by a cervical dedicated protocol. Two physicians blindly reviewed the exams and the results were discussed with surgeons to determine the therapeutic impact of the dedicated protocol. Result: Among 30 patients, only four (13%) discordant results were registered by the both observers, and two more by only one observer (k = 0.75, S.D. = 0.08). As to the four patients: 1) a N0 staged patient on whole body (W.B.) exam was upstaged to N2b in cervical PET (obese patient, whole-body exam with poor quality), 2) for a second patient, no node was described on whole-body scan, but one lymph node in each cervical chain was observed in focused PET, with low standardized uptake value (S.U.V. value), 3) in the other two cases, cervical PET scan upstaged from N2a to N2b and from N2a to N2c (S.U.V. < 3), without any influence on treatment management. Conclusion: Our results show that additional cervical dedicated PET-CT does not modify the management of patients with H.N.S.C.C. when compared to whole-body PET-CT, except for particular obese or N0 patients, allowing to reduce patient CT radiation dose and time-consuming PET acquisition. (authors)

  11. About a case of prostate lymphomatous injury: initial evaluation and early therapy evaluation by PET/T.D.M. with {sup 18}F-F.D.G; A propos d'un cas d'atteinte lymphomateuse prostatique: bilan initial et evaluation therapeutique precoce par TEPTDM au F-18 FDG

    Energy Technology Data Exchange (ETDEWEB)

    Cimarelli, S.; Mognetti, T.; Desuzinges, C. [Service de medecine nucleaire, centre Leon-Berard, (France); Lachenal, F.; Sebban, C. [departement de medecine, centre Leon-Berard, (France); Chassagne Clement, C. [departement d' anatomo-pathologie, centre Leon-Berard, Lyon, (France)

    2009-05-15

    The non Hodgkin lymphomas can grow up on organs without any lymphoid tissue. A prostate infiltration occurs in 0.002-1% of the whole ( of non Hodgkin lymphomas). The interest of the positron computed tomography/computed tomography (PET/T.D.M.) with {sup 18}F-fluorodeoxyglucose (F.D.G.) for the initial and post therapy evaluation of aggressive non Hodgkin lymphomas was the object of a recent international consensus. For the early evaluation, its use is still to precise. We report the case of forty four years old man with an aggressive non Hodgkin lymphoma, at an advanced stage with initially a an muscular, ganglion, osteo-medullar prostate overgrowth. We discuss of the interest of the metabolic imaging in this rare clinical form of non Hodgkin lymphoma. (N.C.)

  12. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  13. FDG PET/CT in initial staging and early response to chemotherapy assessment of paediatric rhabdomyosarcomas; Apport de la TEP/TDM au {sup 18}FDG dans la stadification initiale et l'evaluation precoce de la reponse therapeutique des rhabdomyosarcomes pediatriques

    Energy Technology Data Exchange (ETDEWEB)

    Eugene, T.; Ansquer, C.; Oudoux, A.; Carlier, T.; Kraeber-Bodere, T.; Bodet-Milin, C. [Services de medecine nucleaire, CHU Hotel Dieu, 44 - Nantes (France); Corradini, N.; Thomas, C. [Services d' oncologie pediatrique, CHU Hotel Dieu, 44 - Nantes (France); Dupas, B. [Service de radiologie, CHU Hotel Dieu, 44 - Nantes (France)

    2010-12-15

    Purpose: The objective of this study was to retrospectively evaluate the impact of positron emission tomography/computed tomography (PET/CT) using fluorine-18-fluorodeoxyglucose (FDG), in comparison with conventional imaging modalities (CIM), for initial staging and early therapy assessment in paediatric rhabdomyosarcoma. Patients and methods: Prior to treatment, 18 patients (age range, 9 months to 18 years) with histologically proven rhabdomyosarcoma underwent FDG PET/CT in addition to CIM (magnetic resonance imaging of primary site, whole body CT and bone scintigraphy). After three courses of chemotherapy, 12 patients underwent FDG PET/CT in addition to CIM. RECIST criteria and visual analysis of FDG uptake were used for assessment of response. The standard of reference was determined by an interdisciplinary tumor board based on imaging material, histopathology and follow-up data (median = 5 years). Results: PET/CT sensitivity was superior to CIM's concerning lymph node involvement (100% versus 83%, respectively) and metastases detection (100% versus 50%, respectively). PET/CT results changed therapeutic management in 11% of cases. After three courses of chemotherapy, the rate of complete response was 66% with PET/CT versus 8% with CIM. Five percent of patients relapsed during follow-up (median = 5 years). Conclusion: This study confirms that PET/CT depicts important additional information in initial staging of paediatric rhabdomyosarcomas and suggests a superior prognostic value of PET/CT in early response to chemotherapy assessment. (authors)

  14. Brain metastases: epidemiological profile and therapeutic results, about a cohort of patients treated in a radiotherapy department in Algiers; Les metastases cerebrales: profil epidemiologique et resultats therapeutiques, a propos d'une serie de patients traites dans un service de radiotherapie a Alger

    Energy Technology Data Exchange (ETDEWEB)

    Chami, S.; Mekki, F. [Service de radiotherapie, hopital d' Alger, Alger (Algeria)

    2010-10-15

    The authors report a retrospective study of the epidemiological profile, clinic characteristics, and mainly palliative therapeutic treatments, more particularly in terms of life quality, and improvement of clinic symptomatology and performance index. This study is based on 38 patients (17 women and 21 men), with a median age of 58.6, and a Karnofsky index greater than 70 per cent. Various data have been collected: brain metastasis number and topography, time interval between cancer diagnosis and metastasis diagnosis, impact on neuro-cognitive function. Survival has been analysed with the Kaplan-Meier method. Short communication

  15. Application de la resolution de probleme dans une unite de suicidants et suicidaires: premiers resultats aupres de 53 patients hospitalises

    OpenAIRE

    2009-01-01

    Resume La gestion de la crise suicidaire est abordee de plusieurs angles therapeutiques afin de prevenir les recidives. L?accompagnement psychologique des personnes qui percoivent le suicide comme une solution a leur desespoir et a leurs problemes psychosociaux est consideree comme indispensable par les cliniciens. Mais parfois decus de ne pas trouver des reponses rapides a leur detresse, les patients abandonnent souvent leur suivi apres un leger mieux. Nous nous sommes interroges ...

  16. Insight, obsession et verification dans le trouble obsessionnel-compulsif

    OpenAIRE

    Jaafari, N.; Daniel, M.-L.; Lacoste, J.; Bacconnier, M.; Belin, D; Rotge, J.Y.

    2011-01-01

    Resume Introduction ? L?insight a une place centrale dans le trouble obsessionnel compulsif (TOC), il conditionne la prise en charge diagnostique et therapeutique du patient. Cependant, le role de l?insight dans l?emergence des symptomes obsessionnels compulsifs demeure controverse. Dans le but de clarifier le role de l?insight dans le TOC, nous avons evalue la relation entre le degre d?insight et certaines alterations cognitives qui font le lit de l?expression symptomatique. Pour ...

  17. Energy transition and security: which voluntary codes? Energy efficiency: IEA, IEC and ISO dialogue. The European Commission's safety, solidarity and efficiency measures. Securing natural gas supplies and favoring cogeneration. Less energy consuming buildings: rework of the energy efficiency directive. Energy efficiency inside buildings: GDF Suez report; Transition et securite energetiques: quels codes volontaires? Efficacite energetique: dialogue AIE, CEI et ISO. Les mesures de securite, solidarite et efficacite de la commission europeenne. Securiser l'approvisionnement en gaz naturel et favoriser la cogeneration. Des batiments moins gourmands en energie: refonte de la directive sur la performance energetique. Efficacite energetique dans les batiments: GDF Suez au rapport (volontaire)

    Energy Technology Data Exchange (ETDEWEB)

    Tourneur, J.C

    2009-10-15

    This dossier gathers a series of short articles about energy security and efficiency in a context of policy transition. The first paper deals with the use of international standards to promote energy efficiency thanks to efficient public policies and private sector actions. This was the main topic of the mixed workshop organized by the International electrotechnics Commission (IEC) in spring 2009. The second paper presents the new strategic analysis of the European commission in the domain of energy which stresses on the '20-20-20' climate change proposals approved in December 2008. A new European action plan for energy security and solidarity defines 5 domains requiring an extra action to warrant a sustainable energy supply. The commission is also examining the challenges that Europe will have to face between 2020 and 2050. The third article treats of the security of natural gas supplies which represents a quarter of the European Union (EU) energy mix. The supply crises susceptible to occur may have serious economic and social consequences. Therefore, the EU must be prepared to warrant its security of supplies. Cogeneration allows the EU to stay close to its energy goals. Buildings play a key role in the realisation of the EU's energy saving objectives and fight against climate change. The new directive on buildings energy efficiency (2002/91/CE) will allow to exploit this potential of saving and to stimulate sustainable investment and employment as well. Finally, the publication of the second WBCSD (World business council for sustainable development) international report on buildings energy efficiency has led GDF Suez utility to reaffirm its commitment in favour of energy saving and efficiency. (J.S.)

  18. Evaluer l'efficacité d'une campagne de valorisation du bénévolat : Les enseignements de deux expériences contrôlées sur le marché du travail

    OpenAIRE

    Brodaty, Thomas; Emond, Céline; L'Horty, Yannick; Du Parquet, Loïc; Petit, Pascale

    2013-01-01

    2011 a consacré l'Année Européenne du Bénévolat et du Volontariat. Au cours de cette année, les associations ont œuvré pour sensibiliser les entreprises aux compétences développées par les jeunes bénévoles et redéployables dans leur activité professionnelle. Cette campagne de sensibilisation a pris deux formes : d'une part la mise en évidence dans le cadre d'entretiens qualitatifs, des compétences redéployables pouvant être développées par les jeunes dans le cadre de leurs activités de bénévo...

  19. La nécessaire évolution des impératifs d'équité et d'efficacité dans la gestion de l'eau potable en Tunisie

    OpenAIRE

    Touzi, Sarra

    2009-01-01

    The water service in Tunisia has been managed for more than forty years by a public company. A social policy, based on a progressive charging system and a national cross-subsidization had accompanied the service development throughout this period. The sector shows currently good performances with access of the entire urban population and about 92% of the rural population to safe water drinking according to 2007 data. It enters thus in a new phase of development. The aim to increase the supply...

  20. Efficacités et fonctions de la convention collective de travail : étude comparative de l'intervention légale en France et en Espagne

    OpenAIRE

    Cialti, Pierre-Henri

    2013-01-01

    Ce travail vise à réaliser une approche globale des systèmes de négociation collective français et espagnol au travers d’une approche comparative. Dans ce cadre, il apparaît que la loi joue, dans les deux pays, un rôle central. L’appréciation de la portée de son intervention doit cependant conduire, de manière préalable, à envisager le cadre constitutionnel dans lequel elle peut intervenir. Une fois cette étape franchie, suivant la distinction classique entre approche dynamique et statique de...

  1. Efficacité d'une intervention tutorale sur la progression en anglais des étudiants en première année de sciences humaines et sociales

    OpenAIRE

    Entenmann, Frédéric; Cannard, Christine

    2012-01-01

    International audience This exploratory study aims to measure and understand the nature of the impact of proactive in-class tutoring group sessions on the development of first-year Social Sciences students'English skills. Ten tutorials based on a corpus of texts studied in lectures were offered to them between a pretest and a posttest. Even though the results should be interpreted with great care, this paper shows that the students who attended these tutoring sessions obtain better grades ...

  2. Comment évaluer la productivité et l'efficacité des hôpitaux publics et privés ? Les enjeux de la convergence tarifaire

    OpenAIRE

    Dormont, Brigitte; Milcent, Carine

    2012-01-01

    En France les cliniques privées jouent un rôle important dans l’offre de soins hospitaliers. En 2007, 56 % des séjours ont eu lieu dans des hôpitaux publics, 8 % dans des hôpitaux privés à but non lucratifs, qui participent au service public hospitalier (PSPH) et 36 % dans des hôpitaux privés à but lucratif (cliniques). Plusieurs rapports administratifs ont récemment montré qu’un séjour dans un hôpital public ou PSPH était plus coûteux que dans une clinique privée, suggérant que la productivi...

  3. Efficacité de la synchronisation des chaleurs et insémination artificielle chez le bovin Azawak: intérêt du profil de progestérone

    OpenAIRE

    H. Marichatou; Issa, M.; Hamadou, I.; Assane, M; Semita, C.

    2010-01-01

    Efficiency of Estrous Synchronization and Artificial Insemination in Azawak Cows: Interest of the Progesterone Profile. For a few years, the sperm of selected Azawak bull has been used in artificial insemination (AI) on the local bovine races of Niger, to improve the potential of production. Two methods of estrous and ovulation synchronization are compared: vaginal spirals PRID (Progesterone Vaginal Intra Device) and intra muscular injection of GnRH (Gonadotropin Releasing Hormon). For this p...

  4. Les réseaux sur le marché du travail sud-africain. Une efficacité inégale selon le sexe et l'ethnie

    OpenAIRE

    Gaëlle Ferrant

    2012-01-01

    This paper provides evidence that local social interactions within ethnic groups may explain the puzzling variations in labour-market outcomes across individuals. Being surrounded by working peers increases the probability to be employed and wages. This effect differs through a selection effect : gender and ethnic groups who are discriminated against, benefit most from peer effects. The problems of endogeneity and simultaneity of local peer effects are addressed by using data aggregated at th...

  5. Mémoire optique dans un cristal dopé erbium : efficacité, bande passante et analyse du bruit pour les applications de mémoire quantique

    OpenAIRE

    Dajczgewand, Julian

    2015-01-01

    Le traitement quantique de l’information comme moyen de surmonter les limites de l’électronique classique a connu un développement rapide dans les deux dernières décennies. Plusieurs composants pour générer, traiter et envoyer l’information quantique sont nécessaires. Dans ce contexte, les mémoires quantiques optiques apparaissent comme des composantes principales capables de communiquer l’information quantique sur de longues distances en surmontant les pertes des fibres optiques dans un sché...

  6. L’azathioprine dans les maladies inflammatoires chroniques intestinales : impact de son métabolisme sur l’efficacité et la sécurité thérapeutique

    OpenAIRE

    Dewit, Olivier

    2012-01-01

    Thiopurines (TP) are widely used in the management of inflammatory bowel diseases. Side effects and inefficacy are a major concern as they lead to withdrawal of the drug. Tools investigating TP metabolism are useful to avoid inadequate cessation of TP therapy. TP metabolism is complex and many enzymes are involved. Among them, Thiopurine methyl transferase is the only one routinely measured by pheno- or genotyping. A decreased TPMT activity results in a potential overdosing of TP drugs leadin...

  7. Apport des techniques électrochimiques pour l'amélioration de l'estimation de l'efficacité de la protection cathodique des canalisations enterrées

    OpenAIRE

    Barbalat, Maud

    2012-01-01

    Buried gas transmission lines are protected against external corrosion by organic coatings. Cathodic protection (CP) is designed and operated with the aim to mitigate corrosion where coating is faulty. The EN 12954: 2001 standard specifies reference values of the protection potentials according to soil conditions. However some kind of soils, like silt and clay with high resistivity, are not considered by this standard. Moreover, it is necessary to estimate the residual dissolution rate of the...

  8. Assessment of ventilation efficiency for the study of indoor air quality; Appreciation de l'efficacite de la ventilation pour l'etude de la qualite de l'air interieur

    Energy Technology Data Exchange (ETDEWEB)

    Akoua, A.A.

    2004-10-15

    An efficient ventilation system provides a good indoor air quality by eliminating air pollutants and ensuring a satisfactory air renewal. Unlike most research works that deal with test cells with controlled boundary conditions, our study focuses on ventilation efficiency in a real environment. In situ experiments are performed and provide the boundary conditions necessary for CFD (Computational Fluid Dynamics) computations. Using CFD for predicting indoor air quality in a real environment is thus analyzed. The influence of permeability on numerical predictions quality is shown. Unfortunately, it is difficult to quantify accurately the air leakages and their airflow rates. Our study proposes a simplified model that includes air infiltration rates in the CFD computations, and that yields satisfactory results. A critical analysis of ventilation efficiency indices is then performed. It is shown that it is currently impossible to evaluate the air change efficiency ( a e ) in an occupied zone. Concerning the air pollutants removal effectiveness, it is shown that the usual index C e is not suited to ventilation systems with variable airflow rates. For such cases, a new formulation of this index is given. The ratio between the airflow rate and the nominal airflow rate of the ventilation system is also taken into consideration. A coupled analysis of this new index and of this airflow rate ratio enables us to assess the air pollutants removal effectiveness while considering the energetic cost of ventilation. We finally show that there is no universal index. The choice of the index depends on the pollutant, on the pollutant concentration, and on the airflow rate. A tool of decision-making aid is thus proposed in order to evaluate the air pollutants removal effectiveness for various ventilation systems. This tool is flexible and rather simple to use. (author)

  9. After Kyoto: equity stakes and efficiency in the negotiation on the climatic change; Au-dela de Kyoto: enjeux d'equite et d'efficacite dans la negociation sur le changement climatique

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, O.; Criqui, P.; Viguier, L. [Institut d' Economie et de Politique de l' Energie - IEPE-CNRS/ Universite Pierre Mendes-France, 38 - Grenoble (France); Trommetter, M. [Institut National de Recherches Agronomiques (INRA), 38 - Grenoble (France)

    2000-07-01

    The first difficulty to get over in the international negotiation on the climatic change, has been and still remain the distribution of the efforts and the research of the equity in the objective determination. This paper aims to show that facing the different interests of each countries, a single rule of differentiation is not possible. The first part is a review of the different charts of the objectives differentiation discussed or proposed in the international negotiation process on the greenhouse effect. It aims to find a bond between the the charts and the equity. The second part proposes the quantification of a scenario of the emission licenses attribution for 2030 for all the world countries. (A.L.B.)

  10. Bird and chiroptera inventories in Quebec : efficiency of a tried and tested method; Les inventaires d'oiseaux et de chiropteres au Quebec : l'efficacite d'une methode eprouvee

    Energy Technology Data Exchange (ETDEWEB)

    Castonguay, M. [Pesca Environnement, Maria, PQ (Canada)

    2007-07-01

    Environmental monitoring at wind turbine arrays is needed before, during and after project development. Pesca Environmental evaluates the impact of proposed wind turbine arrays on birds and chiroptera by examining their migration patterns through visual and auditory observations during the springtime reproductive and nesting season as well as in the autumn. In order to complete a feasibility study, spring migration patterns of birds and chiroptera must be documented and characterized. In addition to building an inventory of birds and chiroptera, Pesca examines bird behaviour and flight patterns and nesting locations. figs.

  11. Efficacité de la synchronisation des chaleurs et insémination artificielle chez le bovin Azawak: intérêt du profil de progestérone

    Directory of Open Access Journals (Sweden)

    Marichatou, H.

    2010-01-01

    Full Text Available Efficiency of Estrous Synchronization and Artificial Insemination in Azawak Cows: Interest of the Progesterone Profile. For a few years, the sperm of selected Azawak bull has been used in artificial insemination (AI on the local bovine races of Niger, to improve the potential of production. Two methods of estrous and ovulation synchronization are compared: vaginal spirals PRID (Progesterone Vaginal Intra Device and intra muscular injection of GnRH (Gonadotropin Releasing Hormon. For this purpose, seven and six Azawak Females were successively used by treatment. AI were carried out twice at 56 h and 68 h for the PRID, and 20 h and 44 h for the GnRH, after stop of the treatment. Heats appearance was controlled by direct observation during the 7 days following the end of the treatment. Blood were carried out for ten females (5 of each batch three times per day from J9 to J16, then once daily until J27, and finally at twice-weekly intervals during the 5 weeks which followed, in order to establish a profile of plasmatic progesterone by animal. In addition, a pregnant diagnosis was carried out per transrectal palpation, three months after AI. For each of the two treatments, three females expressed estrus, including two before the first AI, and the third later (1 and 5 days respectively for the PRID and GnRH. The increase of plasmatic progesterone rate of these two cows, occurred in the two days after the first AI, with a pregnant on both for the PRID, and two for GnRH. The three whose heats were not noted, were not pregnant in both cases, and had an increase in the plasmatic progesterone rate 3 and 8 days after the first AI respectively for the PRID and GnRH. In conclusion, we did not observe a difference in the answers of two treatments. Moreover, the females without estrus observed, were showed a normal cycle (by the progesterone profile but with late ovulations that have not allowed fecundation. These results suggest us once more, to make the first IA as of the appearance of heats, and in addition, to inseminate only on heats observed.

  12. Efficacy of ondansetron in the management of radiotherapy induced emesis: a review. Efficacite de l'ondansetron dans les nausees et vomissements radio-induits: revue de la litterature

    Energy Technology Data Exchange (ETDEWEB)

    Levy, E. (Hopital Henri-Mondor, 94 - Creteil (France)); Paillarse, J.M.; Votan, B. (Laboratoires Glaxo, 75 - Paris (France))

    1994-01-01

    Radiotherapy-induced emesis depends on the site of irradiation, the field size and the dose per fraction and is generally less intense than chemotherapy-induced emesis. Established anti-emetic drugs offer only limited symptom control (50%). Ondansetron, a 5HT[sub 3] receptors antagonist, had proven a complete or a major control efficacy (0-2 emetic episodes) of 68 to 95% in three pilot studies (fractionated, single-dose and total body irradiations). In controlled studies, ondansetron efficacy was significantly higher than placebo, metoclopramide and prochlorperazine. The treatment was well tolerated in the different studies. (authors). 23 refs., 2 figs., 1 tab.

  13. Effet du mode de conservation de l'huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L.) Walp. au Niger

    OpenAIRE

    Abdoul Habou, Z.; Adam, T; Mergeai, G.; Haubruge, E.; Verheggen, FJ.

    2014-01-01

    Influence of the Conservation Mode of Jatropha curcas L. oil on its Efficacy in the Control of Major Insect Pests of Cowpea (Vigna unguiculata (L. Walp) in Niger. Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to light and the other kept in the dark. The insecticidal efficacy was evaluated in a field with three concentrations (5, 10 and 15%) tri...

  14. Effet du mode de conservation d’huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L.) Walp. au Niger

    OpenAIRE

    Abdoul Habou, Zakari; Toudou, Adam; Haubruge, Eric; Mergeai, Guy; Verheggen, François

    2014-01-01

    L'huile de Jatropha curcas possède une activité insecticide mise à profit par les agriculteurs nigériens. Dans cette étude, nous avons comparé l'activité insecticide de deux lots d'huile conservés pendant 70 jours, l'un exposé à la lumière et l'autre conservée à l'obscurité. L’effet insecticide a été évalué dans un essai au champ avec trois concentrations (5, 10 et 15%) sur les principaux ravageurs du niébé (Vigna unguiculata (L.) Walp) et au laboratoire sur Megalurothrips sjostedti Trybon (T...

  15. Evaluation de l'efficacité anthelminthique des extraits éthanoliques de graines de papaye (Carica papaya L.) contre l'ascardiose aviaire à Ascaridia galli chez le poulet de chair

    OpenAIRE

    Djitie Kouatcho, F.; Komtangi, MC.; Mpoame, M.

    2008-01-01

    Evaluation of the Efficiency of Ethanolic Extracts of Papaw Seeds (Carica papaya L.) against Ascaridia galli Ascaridiasis in Broiler Chicken. A study was carried out to study the efficiency of ethanolic extracts of papaw seeds against Ascaridia galli ascaridiasis in broiler chicken. Fifty-four 7 days old ISA 15 VEDETTE broilers raised in the Practical Training and Research Farm of Dschang University in Cameroon were inoculated with 1 ml of suspension containing approximately 100 embryonated A...

  16. Evaluation de l'efficacité anthelminthique des extraits éthanoliques de graines de papaye (Carica papaya L. contre l'ascardiose aviaire à Ascaridia galli chez le poulet de chair

    Directory of Open Access Journals (Sweden)

    Djitie Kouatcho, F.

    2008-01-01

    Full Text Available Evaluation of the Efficiency of Ethanolic Extracts of Papaw Seeds (Carica papaya L. against Ascaridia galli Ascaridiasis in Broiler Chicken. A study was carried out to study the efficiency of ethanolic extracts of papaw seeds against Ascaridia galli ascaridiasis in broiler chicken. Fifty-four 7 days old ISA 15 VEDETTE broilers raised in the Practical Training and Research Farm of Dschang University in Cameroon were inoculated with 1 ml of suspension containing approximately 100 embryonated A. galli eggs per bird. The broilers, divided into 3 groups of 18 birds, after 47 days, received either 0 g/l, 1.5 g/l and 3 g/l of ethanolic papaw seeds extracts administered one time only and corresponding to Do, D3/2 and D3 treatments. The reduction rates of number of eggs per gramme of faeces were 2.4%, 72.7%, 82.1% for treatment Do, D3/2 and D3 respectively. The reduction rates of parasitic load were 49% and 76% respectively for treatment D3/2 and D3 compared to parasitic load obtained from control Do at autopsy. Average weight gains a week after treatment was 108 g, 297 g and 400 g in Do, D3/2 and D3 treatment respectively. Ethanolic extracts of papaw seed appear to be efficient in the treatment of A. galli ascaridiasis at the doses of 1.5 g/l and 3 g/l in broiler.

  17. Strategy and development means of the energy efficiency and renewable energies sources in France; Strategie et moyens de developpement de l'efficacite energetique et des sources d'energies renouvelables en France

    Energy Technology Data Exchange (ETDEWEB)

    Cochet, Y.

    2000-09-01

    In the framework of the renewable energies development policy and the energy mastership wanted by the Government, a document has been asked by the Prime Minister. It evaluates the development prospects at long and medium dated, of the main chains of renewable energies production taking into account the national developable deposits size, the technologies assessment, the environmental impacts and the competition facing the traditional energies. It evaluates the measures leading to an increasing efficiency. Measures concerning the regulations, the budget, and the fiscality are also discussed. From these analysis, a national strategy for actions in favor the renewable energies, are proposed. (A.L.B.)

  18. L'efficacité énergétique des protocoles de transport fiables pour les réseaux sans fil à faible consommation d'énergie

    OpenAIRE

    Ayadi, Ahmed

    2012-01-01

    Low power and Lossy Networks (LLNs) such as wireless sensor networks are currently used in many important applications fields such as remote environment monitoring and target tracking. This deployment has been enabled by the availability, especially in recent years, of embedded micro-controller devices that are smaller and cheaper. These devices are equipped with wireless interfaces, with which they can communicate with each other to form a network. In this thesis we focus on studying the ene...

  19. Marketing social et efficacité des campagnes de prévention de santé publique : apports et implications des récents modèles de la communication persuasive

    OpenAIRE

    Marchioli, Audrey

    2006-01-01

    National audience Illustrating an example of persuasive communication applied to marketing, the article shows how research in public health communication can help social marketing to change health behaviors and increase campaign's effectiveness. According to a both scientific and operational objective, the article considers, after a presentation of the recent persuasive models, their contributions to social marketing as well as useful implications for practitioners. Illustrant un exempl...

  20. Etude des facteurs contrôlant l'efficacité de la sélection génomique chez le palmier à huile (Elaeis guineensis Jacq.)

    OpenAIRE

    Cros, David

    2014-01-01

    La production agricole doit augmenter à un rythme jamais atteint pour faire face à la forte hausse attendue de la demande alimentaire. La sélection génomique (SG) pourrait y contribuer en donnant la possibilité de sélectionner des individus uniquement sur leur génotype, rendant ainsi l’amélioration génétique des rendements plus efficace. L’amélioration actuelle de la production du palmier à huile, première plante oléagineuse au monde, se fait par sélection récurrente réciproque pour produire ...

  1. Efficacité de la technique d'induction florale d'Ananas comosus (L. Merr. au moyen de charbon actif enrichi à l'éthylène (TIFBio

    Directory of Open Access Journals (Sweden)

    Lebeau F.

    2009-01-01

    Full Text Available Efficiency of the Ananas comosus (L. Merr. flower induction treatment based on ethylene enriched activated carbon (TIFBio. Pineapple is an important export crop for tropical countries. The flower induction treatments are essential to the pineapple production for economical and social reasons. For conventional agriculture, many chemicals are available but for organic farming ethylene is the only allowed product. A new flower induction method suited to small organic growers has been developed by the Pesticides Initiative Programme of the Coleacp funded by the European Development Fund. The trials conducted proved that the method reaches more than 80% efficiency at 10 weeks for the different application methods evaluated. The wet application trials show a doses response effect as well as effect of the application replication at 2 days interval. The flowering rate culminates at 100% after 8 weeks for the best results, obtained with the wet treatment at 250 mg per plant applied two times at 2 days interval. The different dry treatments tested gave all 85 – 90% flowering rates at 10 weeks, suggesting the presence of an undetermined limitation factor in the conditions prevailing for the trial. The time of application during the day shows no significant effect. It is concluded that the growers can use the TIFBio technique for production control. It is recommended to evaluate the most suited application technique according to their particular case as environmental effect can affect the efficiency.

  2. Fission product removal by containment spray - influence of the distance between the drops on the aerosol collection efficiency; Influence de la densite spatiale des gouttes d'aspersion sur l'efficacite de collecte des produits de fission

    Energy Technology Data Exchange (ETDEWEB)

    Gauchet, N

    2000-07-01

    This work is within the framework of the studies that are conducted at the IPSN concerning the loss of coolant in a nuclear reactor. During this kind of accident, a spray system in the reactor containment induces the scrubbing of fission products in the atmosphere, and allows the decrease of their concentration in the containment. Our objective is to study the influence of the distance between the drops of their aerosol collection efficiency. This is not taken into account in the existing models. We stimulate the various aerosol collection mechanisms with one free falling drop using computational fluid dynamics codes. The mechanisms are: deposition by brownian diffusion, impaction and interception of the particles by the drop, and collection of particles in the presence of steam condensation at the surface of the drop. These phenomena are studied for drops ranging in diameter from 100 to 700 micrometers, falling in a saturated air-steam mixture whose temperature varies between 20 and 140 degrees Celsius, and total pressure varies between 1 and 5 bars. We validate these models with results available in the literature and with experimental results CARAIDAS. Then we apply these models to the case of three aligned drops, which constitutes a case for which the proximity of the drops has a strong influence on the collection of aerosols. While varying the distance between the drop from 5 to 25 drop diameters, we can highlight the modification of the collection efficiency of each mechanism related to the disturbance of the velocity and concentration fields in the vicinity of the drops. We note that the strongest variations of efficiency observed are in the field of impaction, and that the steam condensation at the surface of the drops limits the decrease. (authors)

  3. Garantir l'efficacité des opérations de prévention des incendies de forêt. Un réseau pour une maîtrise à moyen terme

    OpenAIRE

    Etienne, Michel; Rigolot, Eric

    2003-01-01

    Cet été encore, les incendies ont très souvent fait la une des médias nous rappelant que la forêt méditerranéenne brûle pendant la saison touristique. La récurrence de ces sinistres malgré les mesures déjà mises en place nous a conduit à bâtir et faire vivre le Réseau Coupures de Combustible, lieu d'échange et de réflexion entre chercheurs, gestionnaires, services de développement, services administratifs et services de lutte contre les incendies sur l'ensemble de la région méditerranéenne fr...

  4. Melanoma vectorized radiotherapy: anti tumoral efficiency of a new marker labelled by iodine 131; Radiotherapie vectorisee du melanome: efficacite antitumorale d'un nouveau vecteur marque par l'Iode 131

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet-Duquennoy, M.; Papon, J.; Miot-Noirault, E.; Madelmont, J.C.; Chezal, J.M.; Moins, N. [EA4231, universite d' Auvergne, Clermont-Ferrand, (France); Mishellany, F.; Cayre, A. [laboratoire d' anatomopathologie, centre Jean-Perrin, Clermont-Ferrand, (France); Maublant, J. [service de medecine nucleaire, centre Jean-Perrin, Clermont-Ferrand, (France); Guerquin-Kern, J.L. [Inserm U759, laboratoire de microscopie ionique, institut Curie, Orsay, (France)

    2009-05-15

    The melanoma is an invasive pathology for which no treatment is efficient on the disseminated form. The works of the Laboratory aim to conceive molecules presenting a specific affinity for the melanoma by targeting the melanin. The aim of this project is to evaluate for the mouse, the anti tumoral effect of vectorized {sup 131}I by the tracer ICF01012 that presents a durable and specific tumor concentration adapted to an application in internal vectorized radiotherapy. Conclusions: A significant anti tumoral effect of the internal vectorized radiotherapy using the compound {sup 131}I-ICF01012 is demonstrated on two models of melanomas whatever their aggressive potential is. This effect is associated to a inhibition of the tumor cells dissemination towards lungs. The optimization of the therapy protocol is running in order to get a maximal therapy efficiency associated to a controlled toxicity of non-targeted pigmented organs. (N.C.)

  5. Efficacité de la roche phosphatée de Matongo au travers d'un compostage sur une culture de pomme de terre sur un sol acide de Rabiro (Burundi

    Directory of Open Access Journals (Sweden)

    Van den Berghe, C.

    1993-01-01

    Full Text Available Efficiency of phosphatic rock from Matongo applied in the composting process on potatoes on an acid soil of Rabiro. In the frame of the Cooperation between the CVHA (Cultures Vivrieres de Haute Altitute Project and the Program of Fertilisation of the Agro-systems on Altitude (FAVA of the Faculty of Agricultural Sciences in Burundi, the local phosphatic rock from Matongo has been compared to diammonium-phosphate when added in the composting process. The field trials with potatoes have shown that both phosphate sources have the same fertilizing value when the enriched compost was applied at the dose of 20 t/ha. It is very interesting from agricultural and economical viewpoint to use this phosphatic rock in combination with compost.

  6. Effet du mode de conservation de l'huile de Jatropha curcas L. sur son efficacité dans la lutte contre les principaux insectes ravageurs du niébé (Vigna unguiculata (L. Walp. au Niger

    Directory of Open Access Journals (Sweden)

    Abdoul Habou, Z.

    2014-01-01

    Full Text Available Influence of the Conservation Mode of Jatropha curcas L. oil on its Efficacy in the Control of Major Insect Pests of Cowpea (Vigna unguiculata (L. Walp in Niger. Jatropha curcas oil has an insecticidal activity harnessed by the farmers in Niger. In this study, we compared the insecticidal activity of two batches of oil conserved during 70 days, one exposed to light and the other kept in the dark. The insecticidal efficacy was evaluated in a field with three concentrations (5, 10 and 15% trial on the main pests of Cowpea (Vigna unguiculata (L. Walp and in a laboratory test on Megalurothrips sjostedti Trybon (Thysanoptera: Thripidae with different concentrations of crude oil (50; 100; 150 and 200 µl. No difference in insecticidal effect was found between the two modes of oil conservation, both in the laboratory and in the field. In the field, regardless of the mode of conservation, the concentrations of 10% of J. curcas oil enables a reduction of over than 80% of thrips, aphids, and bugs compared to the control. Its increased seeds yield more than 50%. The concentration of 15% gives an insecticidal effect comparable to that of the reference treatment (deltaméthrine but induces phytotoxicity symptoms on the leaves of Cowpea.

  7. Contribution to the study of hybrid ventilation system effectiveness in office and educational buildings; Contribution a l'etude de l'efficacite des systemes de ventilation hybride dans les batiments du secteur tertiaire

    Energy Technology Data Exchange (ETDEWEB)

    Cron, F.

    2004-06-15

    This study is part of the International Energy Agency Annex 35, 'Hybrid Ventilation in New and Retro-fitted Office Buildings', also called the HybVent Project. It presents the numerical analyses of a number of hybrid ventilation systems and their potential for several buildings in relation to local climate characteristics. The first part of this work reviews the state-of-the-art of existing ventilation systems and details the principles, expectations and features of hybrid ventilation systems. This first section also examines some examples of hybrid systems extracted from the collection of Annex 35 case studies. A comprehensive bibliography of numerical tools available for this type of analysis is given in the second section. The numerical models for building simulation and the object-oriented environment used to develop our simulation tool are presented in this section as well. Two single-zone studies undertaken in this project are reported in the third section. The first study concerns an experimental cell simulation. Numerical results are compared to experimental data to validate the use of the simulation tool developed. The second single-zone study predicts the potential of a specific hybrid ventilation system in a typical classroom, given climatic conditions. Finally, the last section presents a more complete study - a multi-zone study of the Tonga school, an Annex 35 case study located in Sweden. Three rooms were modelled initially to compare numerical results to experimental data and then to analyse the performance of the existing hybrid ventilation system and two other systems. This final study was completed for three European cities with very different climates. The overall analysis of the potential of the hybrid ventilation systems considered and the perspective for future work are outlined in the conclusion. (author)

  8. Place of imaging in the evaluation of treatment response in breast cancer;Place de l'imagerie dans l'evaluation de l'efficacite des traitements dans le cancer du sein

    Energy Technology Data Exchange (ETDEWEB)

    Brunotte, F.; Berriolo-Riedinger, A.; Cochet, A.; Toubeau, M.; Dygai-Cochet, I.; Riedinger, J.M. [Centre Georges-Francois-Leclerc, Service de medecine nucleaire, 21 - Dijon (France); Brunotte, F.; Cochet, A. [Universite de Bourgogne, UMR CNRS 5158, laboratoire electronique, informatique et image, 21 - Dijon (France)

    2010-01-15

    This paper describes, from the current literature, the role of various imaging methods to assess the response to therapy in breast cancer. Two different clinical situations are considered: neo-adjuvant chemotherapy of locally advanced breast cancer and the metastatic breast cancer. Significant clinical data are available for three criteria: the volume of the tumour, the uptake of fluorodeoxyglucose using PET and the perfusion of the tumor evaluated either by dynamic contrast-enhanced magnetic resonance imaging (D.C.E.-MRI) or by PET using {sup 15}O water. {sup 18}F F.D.G. PET allows prediction of the response after one or two cycles of neo-adjuvant chemotherapy. New approaches will offer opportunities to refine the role of imaging in monitoring the response to chemotherapy. PET using thymidine as bio marker is promising in assessing the tissular proliferation. Estrogen analogs could be used to predict hormonally responsive breast cancer. Many other approaches, although less developed, might offer new insights in the response to therapy of breast cancer like magnetic resonance spectroscopy or optical imaging of hemoglobin oxygenation. Imaging also offers potential of monitoring the down-regulation of specialized receptors of the cell membrane in response to treatment: the most studied receptor in preclinical model has been the human epidermal growth factor receptor type 2 (HER2). Integrin, a family of cell adhesion receptor, is also an important target for imaging. Apoptosis, multidrug resistance and hypoxia can also be studied using appropriate bio markers. To allow reliable multicenter trials of new drugs, these different imaging approaches still require an improved standardization of image acquisition and processing. (authors)

  9. Pierre Muller, La société de l’efficacité globale. Comment les sociétés modernes se pensent et agissent sur elles-mêmes

    OpenAIRE

    Giry, Johan

    2015-01-01

    Le présent ouvrage de Pierre Muller s’inscrit dans la continuité de ses précédents travaux, pionniers en matière d’analyse des politiques publiques en France. Il s’en distingue toutefois par le regard réflexif porté sur le modèle théorique développé depuis maintenant plus de trente ans et par le prolongement analytique qui lui est donné au vu des transformations récentes de l’action publique et des sociétés dans lesquelles elle prend place. À une époque, celle des années 1980, où se développa...

  10. The economical impact and the environmental efficiency of the ISO 14001/EMAS certification of industrial companies; L'impact economique et l'efficacite environnementale de la certification ISO 14001/EMAS des entreprises industrielles

    Energy Technology Data Exchange (ETDEWEB)

    Backer, P. de

    1999-07-01

    The 1836/93 EMAS is the European regulation on environmental management and auditing scheme. Its aim is to answer the precise requirements of a standard for the management of the environmental impacts of industrial activities. The ISO 14001 standard defines the requirements of an environmental management policy at the international scale. The aim of this study is to make a statement of the enforcement of the ISO 14001 and EMAS environmental management systems in France in terms of results and with respect to the help provided by public authorities. The following aspects are analyzed successively: the aim of the study (context, global goal, hypotheses, cost-benefit analysis, qualitative appraisal); the methodological aspects (selection of sites, sectoral distribution, geographical, legal and financial aspects, data collection, analysis and synthesis); the motivation of companies (sectoral analysis, business aspects, reduction of operation costs, personnel motivation); the objectives of the environmental management system (conformability analysis, environmental goals, effluents, soil pollution, energy and water conservation, wastes, consumption of raw materials, noise and other pollutants); economical aspects (cost, personnel training, audits, benefits, minimization of environmental impacts, reduction of energy, water and materials consumption); cost-benefit evaluation; environmental efficiency of the environmental management system; attitude of other companies; comparison with other European countries; synthesis and proposals. (J.S.)

  11. Stratégies basées sur les brevets et efficacité de la R&D lorsque les innovations sont cumulatives et complémentaires

    OpenAIRE

    Ménière, Yann

    2005-01-01

    La théorie économique aborde généralement le brevet comme un droit exclusif temporaire portant sur un produit ou un procédé, et conférant de ce fait un profit de monopole à l'innovateur. Cette approche permet notamment de mettre en évidence le rôle incitatif du brevet, qui permet de rentabiliser à posteriori les investissements nécessaires à l'innovation. Elle ne permet cependant pas de rendre compte correctement de la réalité des brevets dans de nombreux secteurs, où : - un produit donné peu...

  12. Performances of pleated HEPA filters as a function of relative humidity of air; Performances des filtres plisses a Tres Haute Efficacite en fonction de l'humidite relative de l'air

    Energy Technology Data Exchange (ETDEWEB)

    Joubert, A.

    2009-11-15

    Pleated High Efficiency Particulate Air (HEPA) filters are used for maintaining the containment of radioactive substances in nuclear plants; thus, they are sensitive elements of nuclear safety. Some accidental situations, such as the emergence of a hole on a pipe with release of steam, can lead to a high increase of the air humidity. This work can overcome the lack of analytical data in the literature regarding the behaviour of pleated HEPA filters, in terms of changes in pressure drop and efficiency, in presence of humidity (unsaturated air). Experimental clogging tests have been performed on a test bench with two aerosols: non hygroscopic micron-size alumina particles and hygroscopic sub-micron sodium chloride particles. The results showed that the influence of humidity during the clogging of a HEPA filter depends on several parameters: the geometry of the filter (plane or pleated), the size distribution and hygroscopicity of the aerosol clogging and finally the interaction time between the aerosol and humid air. Measurements of efficiency of clean and clogged filters (at different degrees of clogging), performed with the normalized soda fluorescein aerosol, are also sensitive to the presence of more or less relative humidity in the air. Finally, all results helped to develop an empirical model for estimating the evolution of the pressure drop of HEPA filters; this model is applicable during the formation of the particulate cake in presence of humidity without reducing of the surface area filtration. (author)

  13. Efficacité énergétique et formes urbaines : élaboration d’un outil d’optimisation morpho-énergétique

    OpenAIRE

    Arantes, Laëtitia; Solène MARRY; BAVEREL, Olivier; Quenard, Daniel

    2016-01-01

    Cet article interroge le lien entre formes urbaines et performance énergétique. Aujourd’hui, face aux enjeux du développement durable, de nombreux urbanistes ont choisi de promouvoir la ville compacte. Si le lien entre compacité du bâtiment et performance énergétique n’est plus à prouver, cette relation est moins évidente à l’échelle du quartier, et d’autant moins à l’échelle urbaine, tant la ville est complexe dans sa composition morphologique et spatiale. Cet article analyse d’abord le cont...

  14. Réponses agro-physiologiques et efficacité d'utilisation de l'eau chez le maïs (Zea mays L. - cv. Synthetic-C soumis au déficit hydrique

    Directory of Open Access Journals (Sweden)

    Diouf, M.

    2001-01-01

    Full Text Available Agrophysiological Responses and Water Use Efficiency of Maize (Zea mays L. - cv. Synthetic-C in Water Deficit Conditions. Senegal is known to have very tow rainfall with high probability of drought occurring du ring crop development. The study on the growth of maize under water deficit conditions aimed at characterising its agro-physiological responses and the evaluation of its water use efficiency (WUE. A water deficit was applied respectively during the vegetative phase (T1, at flowering start (T3 and both during the vegetative phase and at flowering start (T2 with a period of rewatering between these two phases. For the control (TO water was applied by irrigation to maintain optimal water conditions for growth. The amount of water to complete (in low rainfall conditions during the cycle was determined by measuring "bac" evapotranspiration and using crop coefficient (Kc for maize during the different phases. The results show that Synthetic-C variety was sensitive to water deficit during the flowering phase. Actually, the relative water content (RWC, leaf water potential and crop water stress index (CWSI were less sensitive to water deficit during the flowering phase than during the vegetative phase. These parameters showed a higher rate of decrease during the vegetative phase. On the other hand, gazeous exchanges [stomatal conductance (Gs and transpiration (Tr] were found to be more sensitive to water deficit during the reproductive stage. Moreover, significantly low grain yield and WUE were observed during this phase of development. However, on the basis of physiological parameters and productivity, Synthetic-C showed a good capacity to resume its physiological activities after rewatering during the vegetative phase, similar to a good plasticity of the control.

  15. Les conditions d'efficacité et d'inefficacité de l'intégration d'élèves en situation de handicap, à l'école primaire: point de vue d'enseignants

    OpenAIRE

    Michaud, Nadia; Doudin, Pierre-André

    2015-01-01

    L'intégration scolaire est un sujet très sensible auprès des enseignants. En effet, les réticences pour accueillir un élève en situation de handicap dans les classes peuvent être nombreuses. D’un point de vue légal, l’Accord Intercantonal sur la collaboration dans le domaine de la pédagogie spécialisée a vu le jour en janvier 2011. Il incite les cantons à préférer les solutions intégratives aux solutions séparatives. On tend ainsi de plus en plus vers le concept de « l’école pour tous ». La p...

  16. Efficacité du vétiver (Vetiveria zizanioides) pour limiter la dispersion de trois micropolluants dans les sols cotonniers et maraîchers du Burkina Faso : endosulfan, cuivre et cadmium

    OpenAIRE

    Ondo Zue Abaga, Norbert

    2012-01-01

    Vetiver was chosen to form hedges around the cotton crops and market gardens in Burkina Faso, in order to limit pollutants dispersal towards plants, surface water and groundwater. The influence of vetiver on the fate of two heavy metals (Cu and Cd) and an insecticide (endosulfan) in the soil-water-vetiver system was studied in two representative soils of Burkina Faso, a vertisol and a lixisol. Batch adsorption coefficient measurements, pot and leaching experiments, under phytotronic and outdo...

  17. Efficacité en pépinière forestière d'un inoculum de champignon ectomycorhizien produit en fermenteur et inclus dans une matrice de polymères

    OpenAIRE

    Le Tacon, François

    1983-01-01

    Pure culture inocula of ectomycorrhizal fungi are usually produced on a vermiculite peat mixture. They can also be prepared by cultivating the fungus in a fermentor and entrapping it in a polymeric gel as proposed by DOMMERGUES et al. (1979) for bacteria and Jung et al. (1981) for different microorganisms. We have prepared different types of inoculum of Hebeloma cylindrosporum as follows : - non washed peat vermiculite inoculum ; - washed peat vermiculite inoculum ; - pellets of myce...

  18. Evaluation de l’efficacité d’un module d’enseignement à distance centré sur l’analyse de tâche et l’émission de feed-back

    OpenAIRE

    Lenzen, Benoît; Gustin, Frédéric; Cloes, Marc

    2006-01-01

    L’importance du feedback dans la relation pédagogique d’enseignement a été mise en évidence dans de nombreuses recherches de type « processus-produit » et les mécanismes relatifs à son émission ont par ailleurs été bien définis. La question qui se pose est la suivante : Comment intervenir dans la formation initiale des enseignants en éducation physique et des entraîneurs afin de développer chez eux l’aptitude à corriger les performances motrices des apprenants ? Peer reviewed...

  19. Disease: H00677 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00677 Aplasia of lacrimal and salivary glands Aplasia of lacrimal and salivary glands (ALSG) is ... 20 PMID:17213838 (description, gene) Entesarian M, Dahl qvist J, Shashi V, Stanley CS, Falahat B, Reardon W ... , Dahl ... N FGF10 missense mutations in aplasia of lacrimal ... ahat B, Bolstad AI, Jonsson R, Wahren-Herlenius M, Dahl ... N Mutations in the gene encoding fibroblast growth ...

  20. Radio active's risk assessment and management following the death of a patient who received a therapeutic dose of iodine-131 as part of a treatment by radioimmunotherapy; Evaluation et gestion du risque radioactif suite au deces d'un patient ayant recu une dose therapeutique d'iode-131 dans le cadre d'un traitement en radiotherapie metabolique

    Energy Technology Data Exchange (ETDEWEB)

    Djoumessi, C.F.; Prunier, C.; Baulieu, J.L.; Besnard, J.C. [CHU de Tours, Service de Medecine Nucleaire, 37 - Tours (France); Djoumessi, C.F.; Bramoulle, C. [CHRU de Tours, Unite de Radiophysique, Clinique d' Oncologie et de Radiotherapie, 37 - Tours (France)

    2009-07-15

    A patient treated with meta-iodobenzylguanidine (Mibg) marked with iodine-131 for malignant pheochromocytoma died three hours after injection. To minimize radioactive risks, the decision to keep the remains for sixteen days was taken. This paper presents the levels of exposure of different persons involved in the care of the patient since his hospitalization until his funeral and the measures taken to prevent radioactive spread and contamination. (authors)

  1. CONGENITAL ABSENCE OF THE VAGINA - RESULTS OF CONSERVATIVE TREATMENT

    NARCIS (Netherlands)

    LAPPOHN, RE

    1995-01-01

    Objective: To assess the efficacy of a combination of Frank's mold therapy with intercourse as a treatment for congenital vaginal aplasia. Study design: From 1973-1993, thirty-three patients with congenital aplasia of vagina and uterus were seen by one gynecologist. Patients with a partner were inst

  2. L'évaluation peut-elle être un outil de la gouvernance territoriale ?

    OpenAIRE

    Méasson, Ludovic

    2008-01-01

    National audience Ce texte discute de l'intérêt et des limites de la manière dont l'évaluation des politiques publiques aborde actuellement les politiques territoriales. Il montre comment l'évaluation peut dans certains cas être facteur d'incertitude pour les élus, plus qu'un outil de management de celle-ci. Il propose enfin de distinguer deux formes d'efficacité - l'efficacité des politiques et l'efficacité politique - dont l'évaluation pourrait accompagner la co-construction que l'on app...

  3. A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)

  4. In vivo preclinical low field MRI monitoring of tumor growth following a suicide gene therapy in an ortho-topic mice model of human glioblastoma;Controle par IRM bas champ in vivo de l'efficacite d'une therapie genique par gene suicide dans un modele murin de glioblastome orthotopique

    Energy Technology Data Exchange (ETDEWEB)

    Breton, E.; Goetz, Ch.; Aubertin, G.; Constantinesco, A.; Choquet, Ph. [Service de biophysique et medecine nucleaire, hopital de Hautepierre, CHRU de Strasbourg, 67 - Strasbourg (France); Institut de mecanique des fluides et des solides, CNRS, universite de Strasbourg, 67 - Strasbourg (France); Kintz, J.; Accart, N.; Grellier, B.; Erbs, Ph.; Rooke, R. [Transgene SA, parc d' innovation, 67 - Illkirch Graffenstaden (France)

    2010-03-15

    Purpose The aim of this study was to monitor in vivo with low field MRI growth of a murine ortho-topic glioma model following a suicide gene therapy. Methods The gene therapy consisted in the stereotactic injection in the mice brain of a modified vaccinia virus Ankara (M.V.A.) vector encoding for a suicide gene (FCU1) that transforms a non toxic pro-drug 5-fluoro-cytosine (5-F.C.) to its highly cytotoxic derivatives 5-fluorouracil (5-F.U.) and 5-fluoro-uridine-5 monophosphate (5-F.U.M.P.). Using a warmed-up imaging cell, sequential 3D T1 and T2 0.1T MRI brain examinations were performed on 16 Swiss female nu/nu mice bearing ortho-topic human glioblastoma (U 87-MG cells). The 6-week in vivo MRI follow-up consisted in a weekly measurement of the intracerebral tumor volume leading to a total of 65 examinations. Mice were divided in four groups: sham group (n = 4), sham group treated with 5-F.C. only (n = 4), sham group with injection of M.V.A.-FCU1 vector only (n = 4), therapy group administered with M.V.A.-FCU1 vector and 5-F.C. (n = 4). Measurements of tumor volumes were obtained after manual segmentation of T1- and T2-weighted images. Results Intra-observer and inter-observer tumor volume measurements show no significant differences. No differences were found between T1 and T2 volume tumor doubling times between the three sham groups. A significant statistical difference (p < 0.05) in T1 and T2 volume tumor doubling times between the three sham groups and the animals treated with the intratumoral injection of M.V.A.-FCU1 vector in combination with 2 weeks per os 5-F.C. administration was demonstrated. Conclusion Preclinical low field MRI was able to monitor efficacy of suicide gene therapy in delaying the tumor growth in an in vivo mouse model of ortho-topic glioblastoma. (authors)

  5. Modélisation à long terme de l'efficacité de scénarios d'optimisation des pratiques agricoles pour la réduction des flux et concentrations de nitrate dans l'eau et d'azote dans l'air à l'échelle de trois bassins versants d'élevage

    OpenAIRE

    Bordenave, P.; Oehler, F.; N. Turpin; Bioteau, T.; Serrand, P.; Saint-Cast, P.; Le Saos, E.

    2006-01-01

    The aim of this paper is to estimate the level of nitrogen emissions (into the air and water compartments) that can result from the adoption of alternative farming practices and manure management. The modelling has been tested on three breeding watershed in the Western part of France. The framework that we developed includes a GIS connected with, on the one side, softwares which design scenarios for farming practices and on the other side a continuously distributed agro-hydrological model. Th...

  6. Régime alimentaire et déplacements des macaques à queue de cochon (Macaca leonina) : impact sur leur efficacité dans la dispersion des graines et sur leur contribution écologique dans une forêt tropicale du parc national de Khao Yai, Thaïlande

    OpenAIRE

    Albert, Aurélie

    2012-01-01

    Southeast Asia experiences an exceptional loss of natural habitat due to a deforestation rate that strongly increased during the last decades. The first consequence is the loss of many animal and plant species, threatened by their habitat degradation and by the loss of interactions necessary to the survival of the whole ecosystem. Large mammals and birds populations, the principal dispersal agent of some plant species, already collapsed massively due to hunting and habitat fragmentation and n...

  7. Charge-collection efficiency of GaAs field effect transistors fabricated with a low temperature grown buffer layer: dependence on charge deposition profile; Efficacite de la collection de charges des transistors AsGa a effet de champ fabriques sur une couche enterree realisee a basse temperature: influence sur le profil de depot de charges

    Energy Technology Data Exchange (ETDEWEB)

    McMorrow, D.; Knudson, A.R.; Melinger, J.S.; Buchner, S. [Naval Research Laboratory, Washington DC (United States)

    1999-07-01

    The results presented here reveal a surprising dependence of the charge-collection efficiency of LT GaAs FETs (field effect transistors) on the depth profile of the deposited charge. Investigation of the temporal dependence of the signal amplitude, carrier density contours, and potential contours reveals different mechanisms for charge collection arising from carriers deposited above and below the LT GaAs buffer layer, respectively. In particular, carriers deposited below the LT GaAs buffer layer dissipate slowly and give rise to a persistent charge collection that is associated with a bipolar-like gain process. These results may be of significance in understanding the occurrence of single-event upsets from protons, neutrons, and large-angle, glancing heavy-ion strikes. (authors)

  8. Banques et transmission monétaire dans l'UEMOA : effets des bilans bancaires, de la concentration bancaire et de l'excès de liquidité bancaire sur l'efficacité de la politique monétaire de la BCEAO

    OpenAIRE

    Ouédraogo, Seydou,

    2011-01-01

    This thesis examines the double underperformance of financial liberalization policies in the WAEMU : the low bank credit and ineffectiveness of the monetary policy. Precisely it studies the impact of bank resilience on bank lending and on the monetary transmission.The thesis provides the following results : 1/ bank balance sheets alter the monetary transmission, small banks, less capitalized and less liquid banks, transmit more fully the monetary shocks 2/ bank concentration weakens the bank ...

  9. Meels: municipalities and energy efficiency in a liberalized system. Guidelines for municipalities: adapting to new roles in a liberalized market; Meels: les municipalites et l'efficacite energetique dans un systeme liberalise. Recommandations detinees aux municipalites: comment peuvent-elles s'adapter a leurs nouveaux roles dans un marche liberalise?

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    Even if the liberalization of energy markets seems to make it more difficult, it also creates opportunities for the committed local authority. Local authorities fulfill their functions in the energy sphere via a number of roles: as a consumer of energy, as a producer of energy, as a distributor of energy, as a trader of energy, as a regulator, planner and policy maker regarding energy using activities, as an awareness tool of the issues relating to energy use and as a provider of incentives to improve energy performance. There are impacts of liberalization on each of these roles. In most, liberalization has not actually changed what they do, only the degree of attention that should be given to it. Only in those areas where trading is involved are new skills necessary, for instance in purchasing energy, in transporting one own energy and in trading energy. In this framework, the following topics are successively analyzed: Improving performance as an energy consumer, improving performance as an energy producer, improving performance as an energy trader, improving performance as an energy distributor, improving performance in delivering sustainable, energy policies at local level and improving performance as a facilitator and awareness programs. (A.L.B.)

  10. Intelligent networks: evolution or revolution? Source of energy efficiency or economical optimisation? For who's benefit?; Reseaux intelligents: evolution ou revolution? Source d'efficacite energetique et/ou d'optimisation economique? Au benefice de qui?

    Energy Technology Data Exchange (ETDEWEB)

    Fontaine, Christian

    2010-09-15

    The electricity sector has experienced a slow evolution. Renewable production developments and telecommunications and computers usage will bring major changes with hard to predict effects. Computerized management of production and local storage combined to a certain mastering of the allowed consumption by home automation could improve reliability and the final price for consumers. This change offers great opportunities but also risks of failures, both financial and technical. The regulators have a major role to play in order to understand the concrete gains of the technological propositions and to regulate the investment costs involved. [French] Le secteur de l'electricite a connu une evolution lente. Le developpements des productions renouvelables, l'utilisation des telecommunications et de l'informatique provoquera un bouleversement majeur dont il est difficile de prevoir l'ampleur. La gestion automatisee des productions et stockages locaux combinee a une certaine maitrise de la consommation permise par la domotique pourrait ameliorer la fiabilite et le prix final pour les consommateurs. Ce changement presente de grandes opportunites mais aussi des risques d'echecs, tant financiers que techniques. Les regulateurs ont un role majeur a jouer pour comprendre les gains concrets des propositions technologiques et reguler les couts d'investissement qu'elles impliquent.

  11. Opinion of Energie-Cites on: Proposals for a directive of the European Parliament and of the Council; Avis d'Energie-Cites sur la: proposition de directive du parlement europeen et du conseil relative a l'efficacite energetique dans les utilisations finales et aux services energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-01

    The Proposal for a Directive on energy end-use efficiency and energy services, published in December 2003, is intended to develop and encourage energy efficiency on the demand side, in particular that provided by utilities and related services companies in the form of energy services, since promoting energy services is an important element for reducing greenhouse gas emissions. This proposal, focusing on the promotion of end-use efficiency, should be regarded as a necessary instrument to complement the recently adopted legislation on the opening of the internal energy market, which mainly leads to efficiency improvements on the supply side. (A.L.B.)

  12. Opinion of Energie-Cites on: proposal for a directive of the European parliament and of the council; Avis d'Energie-Cites sur la: proposition de directive du parlement Europeen et du conseil relative a l'efficacite energetique dans les utilisations finales et aux services energetiques

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-12-01

    This proposal, focusing on the promotion of end-use efficiency, should be regarded as a necessary instrument to complement the recently adopted legislation on the opening of the internal energy market, which mainly leads to efficiency improvements on the supply side. Memorandum Considering that the functioning of the energy market does not allow ''market forces to allocate economic and natural resources effectively'' and that measures should be taken to improve this, the Commission draws up a list of the main obstacles and presents objectives. The technical potential for savings is at about 40%. The economic cost-effective savings potential is at about 20%, 22% in the buildings sector. The general target is 1 % savings per year. The 1,5 % target in the public sector is therefore more ambitious that the general target. According to the Commission, energy efficiency is a strategy to deal with scarce public funds while at the same time addressing serious energy and climate challenges, using the concept of leadership by example. It presents also the economic impact of energy savings targets and explains the reasons why the local authorities are affected by the proposed directive (Municipalities are energy consumers, the municipalities are energy distributors and/or retailers, the municipalities are planners/investors, the municipalities are motivators and local growth and employment are of concern to local authorities). (A.L.B.)

  13. Efficacité comparée de divers procédés physiques de séparation des argiles d'un sable de gisement A Comparison of Different Physical Processes for the Recovery of Clays from an Unconsolidated Sandstone

    Directory of Open Access Journals (Sweden)

    Yvon J.

    2006-11-01

    Full Text Available Divers procédés physiques (mixage, attrition, vibration ultra-sonique ont été utilisés pour désagréger et disperser les argiles d'un sable de gisement. Le traitement aux ultra-sons s'est avéré le plus efficace : après 10 min de vibration on récupère environ 1,5 fois plus de particules fines ( The characterizing of clays is an essential operation for understanding many problems encountered in production. It goes via a preliminary phase in which species are separated quickly and effectively without altering their nature. Chemical processes disperse clays by solubilizing their cements, amorphous compounds and poorly crystallized oxyhydroxides. But they attack fragile species and lead to mistaken results. Therefore, we have chosen various physical processes (mixing, attrition, ultrasonic vibration and compared their efficacy with a reservoir sand. This sand was a quartzose arenite in which 96. 6 % of the grains were between 63 µm and 2 mm. The < 40 µm fine fraction, obtained by wet sieving, represented 2. 44 % of the unprocessed sand, and the clayey fraction (kaolinite, illite, montmorillonite, interstratified illite-montmorillonite was 1. 20%. Mixing was done with a bladed stirer. 40 g of sand and 100 cm³ of demineralized water were stirred for 3 min at a speed of 3000 rpm. Attrition was done by two devices :(1 For attrition by rotation, 400 g of sand and 0. 5 liter of demineralized water were placed in a porcelain jar rotating at a speed of 37 rpm. Tests were performed with water alone and with the adding of a dispersant (0. 3 % sodium hexametaphosphate and a surfactant (0. 6 mole/liter of sodium sulfonate paraoctylphenyl. (2 Attrition by a Turbula TC2 mixer, which gave the jar a complex rotation movement including shaking and rhythmic rocking. 500 g of sand were thus processed in 1 literof 3 % sodium hexametaphosphate solution for varying times. Ultrasonic processing was done with a Sonifer 830 device. The probe was plunged into a suspension made up of 440 g of sand and 300 cm³ of demineralized water processed for times varying from 5 to 100 min. The efficacy of the processing was measured by the weight percent of the < 40 µm fraction. This percentage was 2. 08 % on the average for mixing, 2. 60 % for simple rotation and 2. 87% for rotation by the Turbula device. The adding of dispersant or surfactant had no significant effect. Increasing the rotation time had a minimal effect, in that the percentage of particles recovered went from 2. 21 to 2. 60 % when time increased from 6 to 24 h. Ultrasonic processing was by far the most efficacious and fastest. Indeed, after 5min, an average of 3. 60% of < 40 µm particles was recovered, 4. 10 % after 10 min and7. 18 % after 100 min. The SEM examination of the fractions processed showed that only ultrasonic processing was capable of recovering all of the free clays, either pellicular or trapped in the dissolution cavities or cracks of the quartz grains, i. e. the so-called activeclays. It was also found that this recovery is selective. Montmorillonite and illite are set free at the beginning, while kaolinite is released all during the tests. At the beginning, it was disordered kaolinite, but after 15-20 min of processing, it was ordered kaolinite coming from the microdivision of mica crystals with which it had been associated. This microdivision is clearly visible, moreover, on the cumulative grain-size curve of the < 40µm particles recovered after ultrasonic processing. This curve has two parts:(1 The first part has a steep positive slope linked to the recovery of activeclays. (2 The second part has a much gentler slope linked to the recovery of clayey aggregates and mica and quartz grains microdivided by ultrasounds. The tests performed and a bibliographic study of various processes and operating conditions led us to choose ultrasounds as the process for separating clays from a reservoir sand. The best results were obtained with the following experimental conditions : instrument frequence = 200 kHz, instrument power = 210 W, suspension = 40 g of sand in 300 ml of demineralized water, processing time = 10 min. This quick and efficacious processing preserves the mineral species.

  14. Spatial heterogeneity in utilities, equity and collective efficiency: the case of rural electrification and demand side management; Heterogeneite spatiale d'un service de reseau, equite et efficacite collective: la distribution rurale d'electricite et la maitrise de la demande

    Energy Technology Data Exchange (ETDEWEB)

    Nadaud, F

    2005-11-15

    This thesis has for object the evolution of the economic optimum in the electric industry under spatial equity constraint that present a strong spatial heterogeneity of its supply conditions. One analyses the evolution of the rural electrification regime in France both in terms of economic and social efficiency. We examine the rationality of extending the sectoral optimization under equity constraint to the rationalization of electricity end-uses in the heterogeneous space of rural electricity supply. To this question are given two responses. The firsts pertains to modify the incentives in the institutional regime of rural electrification so the MDE may be integrated in the strategies of rural electrification syndicates. One inspire from incentives mechanisms of the anglo-saxon DSM practice. The second is statistical zoning method of demand and distribution grid whose object is to localize action basins for large scale MDE projects. (author)

  15. L'impact d'un Système Public d'Information sur l'intégration et l'efficacité des marchés : une application du modèle "Parity Bounds" au cas du maïs au Bénin

    Directory of Open Access Journals (Sweden)

    Kpenavoun Chogou, S.

    2013-01-01

    Full Text Available Measuring the impact of Public Market Information Systems on market integration and efficiency: an application of the Parity Bounds Model in maize markets in Benin. During the 1990s, agricultural market reforms prevailed within the economic liberalization undertaken in many sub-Saharan countries. In these countries, government intervention in the commodity markets through marketing boards or parastatal organizations was abandoned in favor of new market reforms. Public Market Information Systems (PMIS thus emerged as part of these reforms. Even though great positive impacts were expected from these reforms, little empirical work has been carried out to evaluate their effects. This article investigates how PMIS has affected the market performance of maize, a major staple food crop in Benin. We use a modified version of the Parity Bounds Model (PBM. This method allows the estimation of the rates of spatial market efficiency or integration, but also the estimation of the rates of market arbitrage, autarky, profitable opportunities and the violation of market arbitrage conditions. Results showed that Benin's agricultural sector suffered from a lack of quality training in how to follow the government-supported market information system implemented in the early 1990s. Subsequently, PMIS did not significantly improve the degree of market integration, although the reforms did induce new marketing opportunities. Results also showed that the impact of PMIS is limited by other market imperfections, such as entry barriers for non-residents or for persons not in local informal trade organizations, and the non-transparent enforcement of formal regulations. This study therefore recommends the implementation of more efficiency-raising policies in order to encourage competition and to allow PMIS to fulfill the expectations of farmers and consumers. Improving food producers and traders' access to reliable information will allow them to better exploit the market opportunities induced by the reforms.

  16. Efficacité des méthodes de lutte contre le développement de cinq espèces de plantes invasives amphibies : Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides et Myriophyllum aquaticum (synthèse bibliographique)

    OpenAIRE

    Delbart, E.; Mahy, G.; Monty, A.

    2013-01-01

    Effectiveness of techniques used to control the development of five invasive amphibious plant species: Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides and Myriophyllum aquaticum. A review. Among rapidly spreading invasive species in Europe, amphibious plants are particularly problematic. These plants are capable of developing a photosynthetic activity both below and above the water surface, and they typically form dense floating populations. Controlling a...

  17. Efficacité des méthodes de lutte contre le développement de cinq espèces de plantes invasives amphibies : Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides et Myriophyllum aquaticum (synthèse bibliographique

    Directory of Open Access Journals (Sweden)

    Delbart, E.

    2013-01-01

    Full Text Available Effectiveness of techniques used to control the development of five invasive amphibious plant species: Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides and Myriophyllum aquaticum. A review. Among rapidly spreading invasive species in Europe, amphibious plants are particularly problematic. These plants are capable of developing a photosynthetic activity both below and above the water surface, and they typically form dense floating populations. Controlling amphibious plants, whether for the purposes of total eradication or for the regulation of their spread, represents an important challenge for managers. A literature review of existing control methods for Crassula helmsii, Hydrocotyle ranunculoides, Ludwigia grandiflora, Ludwigia peploides and Myriophyllum aquaticu was carried out, taking into account efficiency and costs. Of the 87 studies analyzed, a great variation was evident in the research efforts undertaken (number and spatial scale of studies between species and between control methods. However, overall, the different control methods described showed a similar level of efficiency between species. Reports of total eradication of amphibious plants were rare. Such cases resulted from the application of mechanical or chemical methods, most often coupled with complementary methods such as manual finishing. The use of chemical control methods (less laborious and costly than others was found to be frequently documented in the literature. However, except in the case of some active substances, such chemical methods were found to provide low control efficiency. Similarly, to date, biological control has not been found to provide convincing results. In addition, it should be noted that several biological control agents are considered as invasive species in Europe. On the other hand, although little related research has been carried out, methods such as manual or mechanical removal with manual finishing have often been found to result in satisfactory control levels. Aware of the difficulty of controlling amphibious plants, as well as the potential collateral damage caused by control methods to aquatic ecosystems, we argue that consensus still needs to be found between scientists, decision-makers and managers before decisions at regional or national scale can be made.

  18. Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients. Results of the French RTF1 phase 2 trial; Tolerance et efficacite de la radiotherapie de conformation en cas de carcinome hepatocellulaire chez le patient cirrhotique. Resultats de l'essai de phase II RTF1

    Energy Technology Data Exchange (ETDEWEB)

    Mornex, F.; Girard, N.; Wautot, V.; Khodri, M. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-Oncologie, 69 - Pierre-Benite (France); Merle, P.; Kubas, A.; Trepo, C. [Hopital de l' Hotel-Dieu, Service d' hepatogastroenterologie, 69 - Lyon (France); Beziat, C. [Hopital de l' Hotel-Dieu, Dept. de Radiologie, 69 - Lyon (France)

    2005-11-15

    Purpose. - While some patients presenting with hepatocellular carcinoma (HCC) benefit from curative therapies (transplantation, surgery, percutaneous ablation), others are only candidates for palliative options such as chemo-embolization or symptomatic care. Although conventional external-beam radiotherapy of the liver is regarded as little efficient and potentially toxic in cirrhotic patients, 3-dimensional conformal radiotherapy (CRT), by decreasing the amount of normal liver included in the radiation portal, allows dose escalation to occur without increasing the risk of radiation-induced hepatitis. This trial was designed to assess the efficacy and tolerance of CRT for small-size HCC in cirrhotic patients. Patients and methods. - Prospective phase II trial including stage A/B cirrhotic patients with small-size HCC not suitable for curative treatments; CRT consisted in a standard fractionation radiation, with a total dose of 66 Gy. Results. - Twenty-seven patients were included, 15 of whom had previously been treated for HCC; mean age was 68. Among the 23 assessable patients, 18 (78%) presented with complete response, 3 (13%) with partial response, and 2 with no response. Acute complications occurred in 24 patients, and were mainly acceptable (grade 1/2: 22 patients, grade 3/4: 11 patients, 4 (15%) of whom had clinical and/or hematological toxicities). Only 2 (9%) grade 3/4 clinical and/or hematological late toxicities are reported. Conclusion. - CRT is a non-invasive curative technique highly suitable for small-size HCC in cirrhotic patients; further investigations are needed to compare it to the other available treatments, and to integrate it into the curative therapeutic algorithm of HCC. (author)

  19. Aménagement de l’environnement parcellaire en maraîchage biologique: une nouvelle piste pour renforcer l’efficacité des auxiliaires naturels et améliorer la résistance génétique aux pucerons ?

    OpenAIRE

    Lambion, Jérôme; Hureaux, Marion

    2012-01-01

    La biodiversité fonctionnelle consiste à favoriser autour des cultures des espèces végétales qui vont attirer, héberger, nourrir les insectes auxiliaires indigènes participant au maintien des populations de ravageurs sous le seuil de nuisibilité économique. L'objectif est donc de transposer cette technique pour améliorer la lutte contre les pucerons, qui sont parmi les principaux ravageurs dans le Sud de la France, en particulier sur melon (pour lequel aucun produit phytosanitaire n’est auto...

  20. Monte Carlo molecular simulations: improving the statistical efficiency of samples with the help of artificial evolution algorithms; Simulations moleculaires de Monte Carlo: amelioration de l'efficacite statistique de l'echantillonnage grace aux algorithmes d'evolution artificielle

    Energy Technology Data Exchange (ETDEWEB)

    Leblanc, B.

    2002-03-01

    Molecular simulation aims at simulating particles in interaction, describing a physico-chemical system. When considering Markov Chain Monte Carlo sampling in this context, we often meet the same problem of statistical efficiency as with Molecular Dynamics for the simulation of complex molecules (polymers for example). The search for a correct sampling of the space of possible configurations with respect to the Boltzmann-Gibbs distribution is directly related to the statistical efficiency of such algorithms (i.e. the ability of rapidly providing uncorrelated states covering all the configuration space). We investigated how to improve this efficiency with the help of Artificial Evolution (AE). AE algorithms form a class of stochastic optimization algorithms inspired by Darwinian evolution. Efficiency measures that can be turned into efficiency criteria have been first searched before identifying parameters that could be optimized. Relative frequencies for each type of Monte Carlo moves, usually empirically chosen in reasonable ranges, were first considered. We combined parallel simulations with a 'genetic server' in order to dynamically improve the quality of the sampling during the simulations progress. Our results shows that in comparison with some reference settings, it is possible to improve the quality of samples with respect to the chosen criterion. The same algorithm has been applied to improve the Parallel Tempering technique, in order to optimize in the same time the relative frequencies of Monte Carlo moves and the relative frequencies of swapping between sub-systems simulated at different temperatures. Finally, hints for further research in order to optimize the choice of additional temperatures are given. (author)

  1. Analyse de l'efficacité des stratégies de travail d'étudiants Lansad à distance dans un dispositif hybride – Étape d'une recherche-action Action research to evaluate ESP students' off site working strategies in a blended learning environment – interim report

    Directory of Open Access Journals (Sweden)

    Cédric Brudermann

    2010-05-01

    Full Text Available Cet article se propose de revenir sur la conception et l'utilisation d'un centre de ressources en ligne visant à mettre en œuvre des expériences d'apprentissage (Bange, 1992 potentiellement favorables à l'acquisition de l'anglais langue étrangère, dans un dispositif hybride d'enseignement / apprentissage des langues pour spécialistes d'autres disciplines (désormais Lansad. Une recherche expérimentale menée à l'institut universitaire de formation des maîtres (désormais IUFM de Perpignan auprès d'un public de professeurs des écoles de niveau B1 / B2 au cours de l'année universitaire 2007-2008 a permis de recueillir des données plus précises quant aux besoins des apprenants au cours de la réalisation de tâches écrites et orales à distance. Leur traitement a montré que la plupart des obstacles provenaient d'aspects de la langue anglaise de niveau A2 / B1 qui avaient déjà été travaillés par les apprenants lors de leurs études dans le secondaire. Pour les aider, un "centre de ressources en ligne" fonctionnant d'après leurs besoins en L2 a été conçu (Brudermann, 2008, de façon à leur laisser toute latitude pour se prendre en charge dans un climat sécurisé lors de la réalisation de ces travaux et les conduire à réinvestir leurs acquis dans l'élaboration de tâches ultérieures (Van Harmelen, 2006.This article deals with the implementation of an online database of pedagogical resources in a blended learning device, in order to lead ESP students to a potential improvement of their English as a foreign language knowledge. Action research was carried out in 2007-2008 in a French University (Perpignan amongst B1/B2 teachers-to-be ESP students. The data collected showed that most linguistic obstacles derived from A2/B1 elements they had already been taught during their secondary education. A database of pedagogical resources was set up online to provide students with relevant items and links when needed, whilst doing tasks and help them reinvest and reflect upon their FL knowledge (Van Harmelen, 2006.

  2. A Test of the Efficacy of Exchange Rate Adjustments in Indonesia (Détermination de l'efficacité de l'ajustement du taux de change opéré en Indonésie) (Una prueba de la eficacia de los ajustes del tipo de cambio en Indonesia)

    OpenAIRE

    G. Russell Kincaid

    1984-01-01

    This paper analyzes the impact of relative prices on the non-oil trade account in Indonesia, with special emphasis on the effectiveness of the exchange rate adjustment of November 1978. An exchange rate adjustment can successfully redirect resources into export and import-competing activities only if the more favorable cost-price relationship established immediately following the devaluation is not subsequently reversed by domestic price increases. During the first year following the Indonesi...

  3. Traitement diététique de l'hypercholestérolémie légère à modérée. Efficacité de différentes interventions.

    OpenAIRE

    Gosselin, P.; Verreault, R.; Gaudreault, C.; Guillemette, J.

    1996-01-01

    OBJECTIVE: To compare the efficacy of brief dietary intervention by family physicians in their daily practice and in group sessions to standard dietetic treatment in mild to moderate hypercholesterolemia. DESIGN: Randomised clinical trial. SETTING: Family practice clinic in a remote community. PARTICIPANTS: Between September 1, 1991 and September 30, 1992, 135 men and women between 20 and 60 years old with mild to moderate hypercholesterolemia were recruited and randomly assigned to three tre...

  4. Adjuvant irradiation in breast cancer patients with A.T.M. gene heterozygous mutations: Special focus on clinical efficacy/toxicity; Toxicite et efficacite de la radiotherapie adjuvante chez les patientes traitees pour un cancer du sein et porteuses d'une mutation heterozygote du gene de l'ataxie-telangiectasie

    Energy Technology Data Exchange (ETDEWEB)

    Chargari, C.; Kirova, Y.M.; Even, C.; Monnier, L.; Dendale, R.; Campana, F.; Fourquet, A. [institut Curie, Dept. de Radiotherapie, 75 - Paris (France); Chargari, C. [Hopital d' Instruction des Armees du Val-de-Grace, Service d' Oncologie Radiotherapie, 75 - Paris (France)

    2009-06-15

    Dysfunction of the ataxia telangiectasia mutated (A.T.M.) gene has been related to defective cell cycle control and genomic instability due to the impaired repair of DNA double strand breaks. Although increased radiosensitivity in A.T.M. heterozygous patients has been suggested in preclinical data, clinical implication of A.T.M. variant remains debated. Despite frequent in vitro hypersensitivity in patients with severe radiation-induced delayed toxicity, heterozygoty for A.T.M. gene does not represent the major cause of unexpected complications after radiation therapy. This might be partially due to potential coexistence of alterations in additional genes that would play a role in development of late radiation-induced adverse response. Although several data suggest that some A.T.M. polymorphisms would increase grade 3 subcutaneous fibrosis at lower doses compared with patients who did not possess these genetic alterations, the relationship between the presence of A.T.M. mutations or sequence variants and radiation-induced toxicity remains controversial in part because of their biological and functional significance. Considering the lack of prospective data, patients with A.T.M. mutation should be considered as candidates for both dose volume and dose reduction clinical trials. (authors)

  5. La dévalaison des smolts de Saumon atlantique au barrage de Poutès sur l'Allier (43 : utilisation de lampes à vapeur de mercure en vue d'optimiser l'efficacité de l'exutoire de dévalaison

    Directory of Open Access Journals (Sweden)

    LARINIER M.

    1991-10-01

    Full Text Available La dévalaison des smolts de saumon atlantique (Salmo salar au barrage de Poutès (43 a été suivie en 1989 afin de tester l'influence de la lumière à vapeur de mercure sur le comportement de dévalaison à travers un exutoire de surface destiné à éviter le transit des poissons par les turbines. Les rythmes d'activité quotidienne, nycthémérale et horaire ont été relevés à l'aide d'enregistrement vidéo. L'activité de dévalaison est essentiellement nocturne, sauf en fin de migration où l'on observe un renversement de tendance. Les observations montrent que si l'effet de la lumière est indubitable, le phénomène est complexe car il dépend de l'intensité des lampes, de la durée de l'éclairage et de la situation des lampes par rapport à la zone où l'on désire concentrer le poisson. L'analyse des résultats met en évidence que l'éclairage de l'exutoire augmente significativement les passages des smolts, mais q u e l'effet n'est pas immédiat : une quinzaine de minutes sont nécessaires pour attirer le poisson dans le clapet, le maximum de passage étant observé au bout d'une demi-heure. De trois à huit fois plus de smolts ont emprunté l'exutoire lorsque les lampes étaient allumées.

  6. Study of a ring-effect ions generator efficiency. Application to the charge and the neutralization of an aerosol cloud; Etude de l'efficacite d'un generateur d'ions a effet couronne. Application a la charge et a la neutralisation d'un nuage d'aerosols

    Energy Technology Data Exchange (ETDEWEB)

    Attoui, M.B. [Paris-12 Univ., Lab. de Physique des Aerosols et de Transfert des Contaminations, 94 - Creteil (France)

    2000-07-01

    The knowledge of the aerosols electric charge is fundamental in the aerosols technology. The aerosols win an electric charge during their generation or in presence of a ionized medium. Facing the regulation hardening in matter of radioactive sources, the author developed a ring-effect ions generator. Tis study presents the first experimental results and discusses the generator performances. (A.L.B.)

  7. Absorption Physique de Composés Organiques Volatils par Pulvérisation d'Emulsion d'Huile dans l'Eau (Etude thermodynamique et hydrodynamique - Application au calcul des efficacités d'abattement de COV sur effluents synthétiques et réels)

    OpenAIRE

    TATIN, Romuald

    2008-01-01

    Les Composés Organiques Volatils peuvent être des composés malodorants, cancérigènes, tératogènes ou mutagènes. En France, la pollution odorante représente le second motif de plainte après le bruit. En conséquence, des réglementations de plus en plus strictes sont imposées aux industriels en termes d’émission de COV. Dans les stations d’épuration, les composés de nature lipophile ne sont pas bien traités par les tours de lavage chimique de la filière de désodorisation. L’élimination de ces co...

  8. Quand la botte prend l'eau, la peau souf(f)re à Cotonou. Intérêt de l'analyse du travail dans la prévention des risques professionnels, la fiabilité et l'efficacité du travail humain

    OpenAIRE

    Beaujouan, Joffrey; Escouteloup, Jacques; Boton-Sourou, Ferdinand

    2012-01-01

    Cette communication est issue d'une expérience récente menée au Bénin dans un contexte de formation-action de futurs infirmiers du travail à l'Université d'Abomey Calavi. Partant d'une situation ordinaire de lavage d'engins articulés dans l'atelier Garage de la SOBEMAP, l'exemple développé met en lumière deux approches différentes pour traiter les questions de prévention des risques professionnels. La première orientée par les risques, la deuxième orientée par l'analyse du travail. Nous propo...

  9. Principaux facteurs influençant l'efficacité de la lumière pulsée pour la décontamination des microorganismes pathogènes et d’altération des denrées alimentaires

    OpenAIRE

    Levy, Caroline

    2010-01-01

    La décontamination microbienne est sujet majeur de préoccupation du secteur agroalimentaire. Des nouvelles technologies physiques de décontamination, dites athermiques, sont d’un emploi croissant. La Lumière Pulsée, utilisée pour décontaminer les surfaces et les liquides clairs, en fait partie. Elle utilise des flashes de lumière blanche riches en UV, et délivrés en moins d'une milliseconde. La plupart des traitements par lumière pulsée sont définis dans la littérature par des paramètres spéc...

  10. Effectiveness of Exchange Rate Policy for Trade Account Adjustment (Efficacité la politique en matière de taux de change pour l'ajustement du solde commercial) (Efecto de la política de tipos de cambio en el ajuste de la balanza comercial)

    OpenAIRE

    Alfred Steinherr

    1981-01-01

    In the past, exchange rate policy has often failed to redress the current account within a medium-run framework of three to six years and in some cases has even led to an accentuation of the imbalance. Typical examples are Japan, the Federal Republic of Germany, and the United States during the late 1960s up to the late 1970s. It is not easy to understand these "perverse" or sluggish effects of exchange rate policy on the basis of existing economic theory. The only explanations offered by thi...

  11. Therapeutic approaches of hematopoietic syndrome after serious accidental global irradiation. Ex vivo expansion interest of hematopoietic cells

    International Nuclear Information System (INIS)

    Aplasia is one of the main syndrome, appearing after one global accidental irradiation by one ionizing radiation source. The hematopoietic syndrome is characterized by a peripheric blood cell number fall; the cell marrow is reduced too

  12. Disease: H00635 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00635 Aniridia Aniridia is a congenital, bilateral ocular malformation defined as iris aplasia ... Genet 33:44-8 (2012) PMID:21850189 (gene) Zhang X, Wang ... P, Li S, Xiao X, Guo X, Zhang Q Mutation spectrum ...

  13. NEOPLASMS

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    920632 Phenotypic analysis of T lympho-cytes from the patient with thymoma com-plicated with pure red cell aplasia. LIUBai(刘白), et al. Beijing Med Univ. Chin J Hema-tol 1992; 13(5): 244-246. The thymocytes in thymoma tissue and mono-nuclear cells in peripheral blood and bone marrowwere obtained from a patient with thymomacomplicated with pure red cell aplasia. The

  14. Radial, renal and craniofacial anomalies: Baller-Gerold syndrome

    Directory of Open Access Journals (Sweden)

    Murthy Jyotsna

    2008-01-01

    Full Text Available The Baller-Gerold syndrome is a rare syndrome with very few cases published in literature. Craniosynostosis and radial aplasia are striking features, easy to diagnose. However, there are many differential diagnoses. Often, the question raised is whether the Baller-Gerald syndrome is a distinct entity. We report a patient with findings of craniosynostosis and radial aplasia consistent with the diagnosis of the Baller-Gerold syndrome. Genotypic heterogeneity could possibly underlie the phenotypic variability exhibited by these cases.

  15. New modalities (setting, fractionation) of radioimmunotherapy by {sup 90}Y-ibritumomab tiuxetan ({sup 90}Y zevalin) in first line treatment of follicular type non Hodgkin malignant lymphomas: efficiency, toxicity and personalized dosimetry approach; Nouvelles modalites (consolidation, fractionnement) de radioimmunotherapie par {sup 90}Y-ibritumomab tiuxetan (Zevalin) en traitement de premiere ligne des lymphomes malin non hodgkiniens de type folliculaire: efficacite, toxicite et approche dosimetrique personnalisee

    Energy Technology Data Exchange (ETDEWEB)

    Morschhauser, F

    2008-12-15

    Rationale: radioimmunotherapy (R.I.T.) with {sup 90}Y-ibritumomab tiuxetan ([{sup 90}Y] Zevalin ) is a new treatment option for patients with relapsed/refractory non Hodgkin follicular lymphoma (F.L.). Efficacy increases when Zevalin is used earlier in the disease course. Currently, Zevalin dosage is based on weight and not dosimetry. This most likely results in a wide range of absorbed dose to critical organs and tumor, which in turn translates in unpredictable efficacy and toxicity. Optimizing R.I.T. with [{sup 90}Y] Zevalin will require its use as part of first-line therapy and implementation of patient-specific dosimetry methods in clinical trials. Objectives and methods: we have consecutively studied 2 new modalities of using Zevalin in first line therapy of F.L.. First, we conducted an international, randomized, phase 3 trial to evaluate the efficacy and safety of consolidation with Zevalin(15 MBq/Kg) in patients with advanced-stage F.L. achieving at least a partial response after induction immuno chemotherapy. A second approach consisted of evaluating a fractionated schedule with 2 doses of Zevalin (11.1 MBq/kg each), 9 to 13 weeks apart, as front line therapy in F.L. patients with high tumor burden. As part of this second approach, we designed a refined imaging-based (planar and 3-dimensional) dosimetry protocol to improve prediction of dose efficacy and toxicity after each dose of zevalin. Data acquisition was performed in 3 centers (Lille, Nantes and Manchester) while data treatment and specific dose calculations for major organ, tumor masses and bone marrow were centralized. Conclusion: Consolidation of first remission with {sup 90}Y-ibritumomab tiuxetan in advanced-stage follicular lymphoma is highly effective with no unexpected toxicities, prolonging P.F.S. by 2 years and resulting in high P.R.-to-C.R. conversion rates regardless of type of first-line induction treatment. Preliminary data show the feasibility of front line fractionated R.I.T. with Zevalin in patient with high tumor burden and of implementing a standardized refined data acquisition/treatment protocol for imaging-based dosimetry in the multicenter setting. Dosimetry results obtained for 6 patients who underwent patient-specific quantitative planar imaging after both Zevalin fractions will be presented. (author)

  16. Report made on behalf of the inquiry commission for the enforcement of the measures preconized for the safety of the maritime transport of hazardous or polluting products and for the evaluation of their efficiency; Rapport fait au nom de la commission d'enquete sur l'application des mesures preconisees en matiere de securite du transport maritime des produits dangereux ou polluants et l'evaluation de leur efficacite

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    On February 5, 2003, three years after the creation of an inquiry commission about the Erika tanker-ship wreck, the principle of a new inquiry commission about the safety of maritime transports was decided by the French house of commons. Its mission is: to evaluate the efficiency of the existing measures of prevention of marine pollution by hydrocarbons, to examine if the preconized safety measures for the transport of dangerous or polluting products are effectively enforced, and to evaluate the status of the transposition of the European directives relative to the control of hazardous ships. This document is the first tome of the report made on behalf of this inquiry commission. It comprises four parts dealing with: 1 - the Prestige tanker-ship wreck and the pollution of Spanish and French coasts: similarities with the Erika wreck but differences in the conditions of crisis management, diverging accident analyses, problems encountered in Spain, a significantly improved management of the crisis by the French administration, the public opinion and the local economy, the global increase of maritime transport and the reduction of accidents frequency; 2 - the real improvements after the Erika wreck: the significant advances but their partial implementation, the acceleration of actions following the Prestige wreck; 3 - the expected and realistic perspectives: the sustain of the political will at the national scale, the concretizing of the European decisions and the follow up of the retained trends, the need for more outstanding evolutions at the international scale; 4 - the international liability and compensation regime: its limitation to the hydrocarbons pollution, the lack of victims indemnification in the case of chemical pollution, the need for an increase of the liability of all actors of the maritime transport and the improvement of the compensation system, a community compensation fund to compensate the inefficiencies of the international compensation mechanisms. (J.S.)

  17. MR tomography of bone marrow changes after high-dose chemotherapy and autologous peripheral stem cell transplantation

    International Nuclear Information System (INIS)

    Purpose: Evaluation of MR standard imaging and short time inversion recovery (STIR) imaging to assess changes in red bone marrow cellularity after high-dose chemotherapy (HDC) and peripheral blood stem cells transplantation (PBSCT). Results: STIR sequences demonstrated marked changes in signal intensity not only until the aplasia occurred but also during bone marrow repopulation. An increased signal intensity was observed after HDC in 13/15 patients (87%), followed by a decrease in signal intensity immediately after aplasia in 14/15 patients (93%). Signal intensity further changed parallel to marrow engraftment in 11/15 patients (73%). T2-TSE only showed clear changes during repopulation in 8/15 patients (53%). The individual course of the signal in T1-TSE was markedly inhomogeneous. Conclusions: STIR sequences show bone marrow edema during aplasia and marrow cellularity during reconstitution and are suitable for characterisation of red bone marrow after HDC and autologous PBSCT. (orig.)

  18. Novel UBR1 gene mutation in a patient with typical phenotype of Johanson-Blizzard syndrome.

    Science.gov (United States)

    Fallahi, Gholam Hossein; Sabbaghian, Mozhgan; Khalili, Manijeh; Parvaneh, Nima; Zenker, Martin; Rezaei, Nima

    2011-02-01

    Johanson-Blizzard syndrome is a rare autosomal recessive disorder, characterized by exocrine pancreatic deficiency and a wide range of other abnormalities. We present here an infant with failure to thrive, exocrine pancreatic deficiency, short stature and developmental delay, cutis aplasia on the scalp, aplasia of alae nasi, hypospadias, hypothyroidism, myxomatous mitral valve, and patent ductus arteriosus. Molecular studies revealed a novel homozygous nonsense mutation in exon 38 of the UBR1 gene, which confirmed the diagnosis of Johanson-Blizzard syndrome. It should be acknowledged that the combination of exocrine pancreatic insufficiency and nasal wing hypo-aplasia is pathognomonic for this syndrome. Prompt diagnosis and exact monitoring of the patients with JBS are required to avoid further complications. PMID:20556423

  19. Le candidat vaccin SPf66 contre Plasmodium falciparum : mythe ou réalité ?

    OpenAIRE

    Robert, F; Gazin, Pierre

    1996-01-01

    Le candidat vaccin SPf66 contre #Plasmodium falciparum$ n'a jusqu'à présent pas fait la preuve de son efficacité. Il est cependant une voie de recherche intéressante méritant d'être approfondie. (Résumé d'auteur)

  20. アリマタイヤのヨセフとロバ : 『ペルレスヴォー』にみる騎士のアイデンティティー

    OpenAIRE

    Yokoyama, Ayumi

    2005-01-01

    Remarque sur la monture de Perceval, la « mule blanche », qui dérive probablement de l'ânesse de Joseph d'Arimathie de I'Evangile de Nicodème. Elle représente avec efficacité l'amvée d'un messie et la « chevalerie céleste ».

  1. Narrow, duplicated internal auditory canal

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, T. [Servico de Neurorradiologia, Hospital Garcia de Orta, Avenida Torrado da Silva, 2801-951, Almada (Portugal); Shayestehfar, B. [Department of Radiology, UCLA Oliveview School of Medicine, Los Angeles, California (United States); Lufkin, R. [Department of Radiology, UCLA School of Medicine, Los Angeles, California (United States)

    2003-05-01

    A narrow internal auditory canal (IAC) constitutes a relative contraindication to cochlear implantation because it is associated with aplasia or hypoplasia of the vestibulocochlear nerve or its cochlear branch. We report an unusual case of a narrow, duplicated IAC, divided by a bony septum into a superior relatively large portion and an inferior stenotic portion, in which we could identify only the facial nerve. This case adds support to the association between a narrow IAC and aplasia or hypoplasia of the vestibulocochlear nerve. The normal facial nerve argues against the hypothesis that the narrow IAC is the result of a primary bony defect which inhibits the growth of the vestibulocochlear nerve. (orig.)

  2. Radiographically visualized skeletal changes associated with mucopolysaccharidosis VI in cats

    International Nuclear Information System (INIS)

    The radiographic skeletal form and structure of all cats with mucopolysaccharidosis VI is described. Common manifestations included epiphyseal dysplasia, generalized osteoporosis, abnormal nasal turbinate development, his subluxation, impaired development of skeletal growth, pectus excavatum, hyoid hypoplasia, aplasia, hypoplasia and fragmentation or abnormal ossification of the dens, and aplasia or hypoplasia of frontal and sphenoid sinuses. The skeletal measurements of two affected cats were compared with those of normal, sex-matched littermates, and the measurements of two affected female cats were compared with those of a normal male littermate

  3. Cleidocranial dysostosis: a report on two familial cases

    Directory of Open Access Journals (Sweden)

    Carlos Guilherme Gaelzer Porciuncula

    2013-12-01

    Full Text Available Cleidocranial dysostosis is a rare genetic syndrome with an autosomal dominant inheritance pattern. The most common manifestations include clavicular aplasia or hypoplasia, open fontanelles and abnormal dentition. The present report describes two familial cases whose late diagnosis was made by means of clinical and radiographic findings. The treatment was radical, with complete surgical teeth extraction and making of total dental prosthesis.

  4. Bilateral ectrodactyly and spinal deformation in a mixed-breed dog

    OpenAIRE

    Carvallo, Francisco R.; Domínguez, Antonio S.; Morales, Pamela C.

    2011-01-01

    A 3-year-old, female mixed-breed dog had malformations of both thoracic limbs and the vertebral column. Radiographs of the forelimbs showed bilateral development of 2 digits and aplasia of 3 carpal bones. Kyphosis, scoliosis, and deformed vertebrae were present in the thoracolumbar vertebral column.

  5. Ectrodactyly/split hand feet malformation

    OpenAIRE

    Jindal Geetanjali; Parmar Veena; Gupta Vipul

    2009-01-01

    Split-hand/split-foot malformation is a rare limb malformation with median clefts of the hands and feet and aplasia/hypoplasia of the phalanges, metacarpals and metatarsals. When present as an isolated anomaly, it is usually inherited as an autosomal dominant form. We report a case of autosomal recessive inheritance and discuss the antenatal diagnosis, genetic counseling and treatment for the malformation.

  6. Genitourinary dysplasia in a cat

    International Nuclear Information System (INIS)

    A six-month-old kitten had congenital urethral sphincter mechanism incompetence due to urethral hypoplasia and associated uterine hypoplasia and vaginal aplasia. Diagnosis was based on radiographic examination, surgical exploration and histological examination of the lower urinary tract. Surgical correction resulted in a marked clinical improvement. The cat became fully continent following treatment with phenylpropanolamine

  7. The morphology of the sella turcica in velocardiofacial syndrome suggests involvement of a neural crest developmental field

    DEFF Research Database (Denmark)

    Mølsted, Kirsten; Boers, Maria; Kjaer, Inger

    2010-01-01

    measure the cranial base angles in individuals with VCFS and, if possible, to discover the developmental field that may be involved in the condition. The study included 33 patients with VCFS from the Copenhagen Cleft Palate Center, Denmark. The genotype was confirmed by fluorescence in situ hybridization...... aplasia, hypothyroidism, and posterior brain abnormality), suggest involvement of a specific developmental field....

  8. How bio-questionable are the different recombinant human erythropoietin copy products in Thailand?

    NARCIS (Netherlands)

    Halim, Liem Andhyk; Brinks, Vera; Jiskoot, Wim; Romeijn, Stefan; Praditpornsilpa, Kearkiat; Assawamakin, Anunchai; Schellekens, Huub

    2014-01-01

    PURPOSE: The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market. This study aims to assess the quality of

  9. Bacterial flora of the sigmoid neovagina

    OpenAIRE

    Toolenaar, T.A.; Freundt, Ingrid; Wagenvoort, J H; Huikeshoven, Frans; Vogel, M.; Jeekel, Hans; Drogendijk, A c

    1993-01-01

    textabstractThe bacterial microbiota of 15 sigmoid neovaginas, created in patients with congenital vaginal aplasia or male transsexualism, was studied. No specimen was sterile, and only normal inhabitants of the colon were cultured. The total counts of bacteria were lower than those reported for healthy sigmoid colons.

  10. Disease: H00600 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00600 46,XX disorders of sex development (Other), including: Mullerian aplasia and...k-Kaufman) MKKS [HSA:8195] [KO:K09492] MeSH: D058489 OMIM: 158330 236700 PMID:18279784 (description, gene) Hughes IA Disorders..., Skordis N Sex determination and disorders of sex development according to the revised nomenclature and cla

  11. Poland's syndrome (A case report)

    OpenAIRE

    Calpur, Osman U.; Aktas, Seref

    2004-01-01

    Poland s syndrome is a rare disease characterized by congenital aplasia of the pectoralis major muscle associated with ipsilateral hand deformities (mosr often synbrachydactylia). In this paper we presented a case of Poland s syndrome with a short review of contemporary literature.

  12. Tracheobronchial Branching Anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Min Ji; Kim, Young Tong; Jou, Sung Shick [Soonchunhyang University, Cheonan Hospital, Cheonan (Korea, Republic of); Park, A Young [Soonchunhyang University College of Medicine, Asan (Korea, Republic of)

    2010-04-15

    There are various congenital anomalies with respect to the number, length, diameter, and location of tracheobronchial branching patterns. The tracheobronchial anomalies are classified into two groups. The first one, anomalies of division, includes tracheal bronchus, cardiac bronchus, tracheal diverticulum, pulmonary isomerism, and minor variations. The second one, dysmorphic lung, includes lung agenesis-hypoplasia complex and lobar agenesis-aplasia complex

  13. Disease: H00637 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00637 Ulnar -mammary syndrome; Schinzel syndrome Ulnar -mammary syndrome (UMS) is an autosomal do ... ateral hypoplasia or aplasia of upper limbs on the ulnar ... side, mammary and apocrine gland hypoplasia, and g ... ene) Linden H, Williams R, King J, Blair E, Kini U Ulnar ... Mammary syndrome and TBX3: expanding the phenotype ...

  14. THE EFFECT OF CYCLOSPORINE ON HEMATOLOGICAL PARAMETERS IN PATIENTS WITH PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA

    NARCIS (Netherlands)

    VANKAMP, H; VANIMHOFF, GW; DEWOLF, JTM; SMIT, JW; HALIE, MR; VELLENGA, E

    1995-01-01

    Four patients with paroxysmal nocturnal haemoglobinuria (PNH) were treated with cyclosporine. The treatment with cyclosporine was based on the hypothesis that immune-mediated bone-marrow damage is the common pathogenetic mechanism of aplasia and PNH, with lack of GPI-linked ligands for an immune att

  15. Cerebellar dermoid tumor and occipital meningocele in a monozygotic twin : clues to the embryogenesis of craniospinal dysraphism

    NARCIS (Netherlands)

    Groen, R J; van Ouwerkerk, W J

    1995-01-01

    A case of monochorionic/monoamnionic twin with discordant occipital developmental malformations is presented. One female twin appeared to have an occipital meningocele with cerebellar aplasia and died immediately after birth. The other twin presented with signs and symptoms of raised intracranial pr

  16. Pathmorphological investigation of pulmonary infections complications in persons dying from acute radiation sickness after Chernobyl accident

    International Nuclear Information System (INIS)

    Lungs of 27 persons who participated in liquidation of Chernobyl accident and died from acute radiation sickness were studied histologically. Pulmonary infections were found, including invasion of viral, bacterial and fungal agents. Being depended on hematopoietic function the inflammatory reactions were areactive during postirradiation aplasia and became typical within the recovery beginning

  17. Mutations in different components of FGF signaling in LADD syndrome.

    NARCIS (Netherlands)

    Rohmann, E.; Brunner, H.G.; Kayserili, H.; Uyguner, O.; Nurnberg, G.; Lew, E.D.; Dobbie, A.; Eswarakumar, V.P.; Uzumcu, A.; Ulubil-Emeroglu, M.; Leroy, J.G.; Li, Y.; Becker, C.; Lehnerdt, K.; Cremers, C.W.R.J.; Yuksel-Apak, M.; Nurnberg, P.; Kubisch, C.; Schlessinger, J.; Bokhoven, J.H.L.M. van; Wollnik, B.

    2006-01-01

    Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3

  18. Cleidocranial dysostosis: a report on two familial cases

    OpenAIRE

    Carlos Guilherme Gaelzer Porciuncula; Ricardo Ferreira de Lira; Maria Lucia Lima Soares; Diego Lisboa Araujo; Lucas Rocha Mota; Larine Ferreira Lira

    2013-01-01

    Cleidocranial dysostosis is a rare genetic syndrome with an autosomal dominant inheritance pattern. The most common manifestations include clavicular aplasia or hypoplasia, open fontanelles and abnormal dentition. The present report describes two familial cases whose late diagnosis was made by means of clinical and radiographic findings. The treatment was radical, with complete surgical teeth extraction and making of total dental prosthesis.

  19. Exencephaly in araucana chickens and silkie bantams.

    Science.gov (United States)

    Griffiths, G L; Softly, A

    1985-01-01

    Exencephaly and hydranencephaly were diagnosed in two 6-week-old araucana chickens (Gallus domesticus) and one adult silkie bantam (Gallus domesticus). The chickens were presented with large, subcutaneous, cranial soft-tissue masses and exhibited neurological signs. There was partial aplasia of the frontal bones, resulting in herniation of the cerebral hemispheres. PMID:4026741

  20. In utero phthalate effects in the female rat: a model for MRKH syndrome##

    Science.gov (United States)

    Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by uterine and vaginal canal aplasia in normal karyotype human females and is a syndrome with poorly defined etiology. Reproductive toxicity of phthalate esters (PEs) occurs in rat offspring exposed in utero, a phen...

  1. In Utero Phthalate Effects in the Female Rat: A Model for MRKH Syndrome

    Science.gov (United States)

    Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is characterized by uterine and vaginal canal aplasia in normal karyotype human females and is a syndrome with poorly define etiology. Reproductive toxicity of phthlate esters (PEs) occurs in rat offspring exposed in utero. a phenome...

  2. Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

    Science.gov (United States)

    2005-06-23

    Purpura, Schoenlein-Henoch; Graft Versus Host Disease; Anemia, Hemolytic, Autoimmune; Rheumatoid Arthritis; Churg-Strauss Syndrome; Hypersensitivity Vasculitis; Wegener's Granulomatosis; Systemic Lupus Erythematosus; Giant Cell Arteritis; Pure Red Cell Aplasia; Juvenile Rheumatoid Arthritis; Polyarteritis Nodosa; Autoimmune Thrombocytopenic Purpura; Takayasu Arteritis

  3. Linking Drugs to Obscure Illnesses

    DEFF Research Database (Denmark)

    Bennett, Charles L; Starko, Karen M; Thomsen, Henrik S;

    2012-01-01

    Identification of serious adverse drug reactions (sADRS) associated with commonly used drugs can elude detection for years. Reye's syndrome (RS), nephrogenic systemic fibrosis (NSF), and pure red cell aplasia (PRCA) among chronic kidney disease (CKD) patients were recognized in 1951, 2000, and 19...

  4. mRNA translation regulation in Diamond Blackfan Anaemia

    NARCIS (Netherlands)

    R. Horos (Rastislav)

    2013-01-01

    textabstractDiamond Blackfan Anemia is a bone marrow failure syndrome in which patients lack erythroid precursor cells in the bone marrow. Therefore, it is also designated as pure red cell aplasia, as other hematological indices are at normal levels. Around half of DBA patients bear an autosomal dom

  5. Quelle place pour la greffe de cellules souches haploidentiques et comment améliorer son efficacité clinique en manipulant, en post-transplantation, l’environnement cellulaire au moyen de l’utilisation de populations cellulaires sélectionnées ou de facteurs solubles modulant l’immunité ?/ The current place of haplo-identical stem cell transplantation and how to improve its clinical outcome by manipulation of the cellular environment post-transplant using selected cellular populations or immunomodulatory soluble factors

    OpenAIRE

    Lewalle, Philippe

    2011-01-01

    Currently, in most situations, the autologous immune system is unable to eradicate the residual leukemic burden persisting after chemo-radiotherapy, but a balance can be established between leukemic and immune cells leading to a clinical remission for several months or years. If this balance is broken, a clinical relapse can occur. The high incidence of relapses in human cancers demonstrates the frequent inefficacy of the immune system to control these residual cells. In this context, allogen...

  6. Macro economic model in agriculture domain for the analysis of the climatic change impact and policies effects in term of efficiency and equity. Short version of the final report at the GICC, february 2002; Modele macro-economique a dominante agricole pour l'analyse de l'impact du changement climatique et des effets des politiques en terme d'efficacite et d'equite. Version abregee du rapport de fin d'etude au GICC, fevrier 2002

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, F.; Piketty, M.G.; Boussard, J.M

    2002-02-15

    The aim of the study is the determination of a detailed model of the world economy, allowing the simulation of the effect of numerous economic policies, especially those which are involved at a world scale to avoid the greenhouse effect gases emissions. This model is based on the previous model, as the GTAP from which the data are used. (A.L.B.)

  7. Molecular guided therapy for advanced pancreatic cancer patients with PI3K activated mutation: vision or illusion?

    Directory of Open Access Journals (Sweden)

    Gazzah A

    2013-02-01

    Full Text Available Anas Gazzah,1 Daniel Barrios Gonzales,1 Antonin Levy,1 Rastislav Bahleda,1 Michel Ducreux,2 Ludovic Lacroix,3 Jean Charles Soria11SITEP (Service des Innovations Therapeutiques Précoces, Department of Medicine, Institut Gustave Roussy, Paris XI University, Villejuif, France; 2Department of Medicine, Institut Gustave Roussy, Paris XI University, Villejuif, France; 3Department of Biology, Institut Gustave Roussy, Paris XI University, Villejuif, FranceAbstract: Despite a modern validated regimen of chemotherapy, advanced pancreatic adenocarcinoma remains the fourth most common cause of cancer-related death worldwide. The phosphoinositide 3-kinase pathway (PI3K/Akt/mammalian target of rapamycin (mTOR is a major signaling pathway that may be activated in advanced pancreatic cancer. To highlight the potential interest of this targetable pathway in selected advanced pancreatic cancer patients, we report herein a patient with an activated PI3K mutation who was treated in a phase I trial evaluating a treatment combination including an mTOR inhibitor.Keywords: pancreatic cancer, PI3K, targeted therapy, molecular profiling

  8. [Adapted Physical Activity for patients with chronic diseases in a therapeutic community].

    Science.gov (United States)

    Bouricha, Rémy; Thöni, Gilles; Raffard, Laurence; Cochet, Laurence; Saucourt, Vincent; Tirode, Véronique

    2015-01-01

    The French therapeutic communities ("Appartements de Coordination Therapeutique (ACT)") are mostly members of the "National Federation of Accommodation for HIV+ and other chronic diseases. They provide accommodation for people living with chronic conditions (HIV hepatitis, cancers...) and in a situation of high psychosocial frailty. As a result of their coordinated multidisciplinary intervention, these structures provide the required support to access health care and facilitate social inclusion. They are designed to provide an appropriate response to people with cumulative medical and social conditions (chronic diseases, precariousness, addictions and other comorbidities). Our innovative local experiment integrates Adapted Physical Activities (APA) into the global medical and social follow-up, in line with the patient's individual health care project. The characteristics of each APA project (nature of the activities proposed, intensity, duration, frequency, individual vs. team activity and accompanying methods) are defined on an individual basis, according to the user's motivations and inputs from the support team (medical, psychological and social coordination). The follow-up ensured by our APA professionals allows the residents to participate in a regular and attractive physical activity and could contribute to their social inclusion. The multidisciplinary approach proposed by ACTs determines the beneficial effects observed in such vulnerable patients. PMID:26168635

  9. Test de produits alternatifs sur Drosophila suzukii en culture de fraise biologique

    OpenAIRE

    Lambion, Jérôme; Klink, Morgane

    2014-01-01

    L’essai réalisé sous abri froid en fin de culture de fraise précoce a permis de mettre en évidence l’intérêt de certains produits pour limiter les attaques de D. suzukii. L’efficacité du Success4 (Spinosad) a été confirmée ; ce produit doit être utilisé avec précaution car il est toxique pour les auxiliaires et les pollinisateurs, et son DAR est de 3 jours. Pyrévert et surtout PréVam ont montré une efficacité nettement insuffisante. Les deux produits microbiologiques Naturalis (Beauveria bass...

  10. Étude multi-échelles des courbes de désaturation capillaire par tomographie RX

    OpenAIRE

    Oughanem, Rezki

    2013-01-01

    L'injection de tensioactifs est une méthode très appliquée dans le domaine de la récupération améliorée des hydrocarbures. Cependant, son efficacité repose sur la capacité de ces agents chimiques à mobiliser l'huile résiduelle en diminuant la tension interfaciale entre l'huile et l'eau. Des modèles à l'échelle du réservoir calculent l'efficacité de la récupération d'huile résiduelle par injection de solutions contenant des tensioactifs. Les mécanismes physiques pris en compte dans les modélis...

  11. Etude et mise au point d'une cellule à électrodes poreuses pour la récupération d'ions métalliques en solution/study of an electrochemical cell with porous electrodes for an environmental application

    OpenAIRE

    Vande Vyver, Olivier

    2008-01-01

    Les procédés électrochimiques présentent beaucoup d’avantages dans le domaine du traitement et de la récupération de matière d’effluents industriels. Cependant, dans le cas de solutions diluées en ions métalliques, les électrodes classiques sont fortement limitées par leur efficacité ainsi que par leur taille. Dès lors, les électrodes poreuses, de par leur surface spécifique importante et de par leur structure particulière qui améliore le transport de matière et donc l’efficacité de l’électro...

  12. Mise en place d'une protection biologique contre Tuta absoluta, ravageur envahissant de la tomate

    OpenAIRE

    Buradino, Maurane; Tabone, Elisabeth; Colombel, Etty; Cordier, Juliette; Legendre, Gaspar; Desneux, Nicolas; Trottin, Yannie; Baffert, Véronique; Leyre, Jean-Michel; Seguret, Julien; Giraud, Marion; Lambion, Jérôme; Lefèvre, Amélie; Ginez, Anthony; Terrentroy, Anne

    2013-01-01

    Dans le cadre de la protection contre Tuta absoluta (projet TutaPI), nous présentons les principaux résultats obtenus. L’objectif est d’améliorer les moyens de biocontrôle actuellement commercialisés, par la recherche d’un nouvel auxiliaire endémique, afin d’augmenter l’efficacité et diminuer les coûts de la protection

  13. Controle quantique grâce aux méthodes de RMN. Application à la simulation de systèmes quantiques

    OpenAIRE

    Negrevergne, C.

    2002-01-01

    Manipuler l'information selon les lois de la physique quantique permet d'ameliorer l'efficacite avec laquelle on traite certains problemes. Les methodes de Resonance Magnetique Nucleaire en solution permettent d'initialiser, de manipuler et d'observer l'etat d'un systeme de spins 1/2 couples. ces methodes ont ete utilisees pour realiser experimentalement un petit processeur d'information quantique (QIP pour "Quantum Information processor") pouvant executer une centaine d'operations elementair...

  14. Maladies telluriques : Les champignons n'auront pas le dernier mot

    OpenAIRE

    Bressoud, Frederique

    2009-01-01

    Des systèmes de culture salade-tomate intensifs ont été mis au banc d'essai afin de tester sur le long terme les effets de la solarisation et des engrais verts en alternative aux désinfections chimiques de sol. Des facteurs favorisant les maladies telluriques et l'efficacité des techniques de remédiation ont pu être mis en évidence.

  15. Evaluation d'une approche pedagogique respectant les facons d'apprendre des filles en sciences et en TIC en 9e annee au Nouveau-Brunswick

    Science.gov (United States)

    Lirette-Pitre, Nicole T.

    2009-07-01

    La reussite scolaire des filles les amene de plus en plus a poursuivre une formation postsecondaire et a exercer des professions qui demandent un haut niveau de connaissances et d'expertise scientifique. Toutefois, les filles demeurent toujours tres peu nombreuses a envisager une carriere en sciences (chimie et physique), en ingenierie ou en TIC (technologie d'information et de la communication), soit une carriere reliee a la nouvelle economie. Pour plusieurs filles, les sciences et les TIC ne sont pas des matieres scolaires qu'elles trouvent interessantes meme si elles y reussissent tres bien. Ces filles admettent que leurs experiences d'apprentissage en sciences et en TIC ne leur ont pas permis de developper un interet ni de se sentir confiante en leurs habiletes a reussir dans ces matieres. Par consequent, peu de filles choisissent de poursuivre leurs etudes postsecondaires dans ces disciplines. La theorie sociocognitive du choix carriere a ete choisie comme modele theorique pour mieux comprendre quelles variables entrent en jeu lorsque les filles choisissent leur carriere. Notre etude a pour objet la conception et l'evaluation de l'efficacite d'un materiel pedagogique concu specifiquement pour ameliorer les experiences d'apprentissage en sciences et en TIC des filles de 9e annee au Nouveau-Brunswick. L'approche pedagogique privilegiee dans notre materiel a mis en oeuvre des strategies pedagogiques issues des meilleures pratiques que nous avons identifiees et qui visaient particulierement l'augmentation du sentiment d'auto-efficacite et de l'interet des filles pour ces disciplines. Ce materiel disponible par Internet a l'adresse http://www.umoncton.ca/lirettn/scientic est directement en lien avec le programme d'etudes en sciences de la nature de 9e annee du Nouveau-Brunswick. L'evaluation de l'efficacite de notre materiel pedagogique a ete faite selon deux grandes etapes methodologiques: 1) l'evaluation de l'utilisabilite et de la convivialite du materiel et 2

  16. Cochlear implant: what the radiologist should know; Implante coclear: o que o radiologista precisa saber

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, Natalia Delage; Couto, Caroline Laurita Batista; Gaiotti, Juliana Oggioni; Costa, Ana Maria Doffemond; Ribeiro, Marcelo Almeida; Diniz, Renata Lopes Furletti Caldeira, E-mail: nataliadelagegomes@gmail.com [Hospital Mater Dei, Belo Horizonte, MG (Brazil). Unidade de Radiologia e Diagnostico por Imagem

    2013-05-15

    Cochlear implant is the method of choice in the treatment of deep sensorineural hypoacusis, particularly in patients where conventional amplification devices do not imply noticeable clinical improvement. Imaging findings are crucial in the indication or contraindication for such surgical procedure. In the assessment of the temporal bone, radiologists should be familiar with relative or absolute contraindication factors, as well as with factors that might significantly complicate the implantation. Some criteria such as cochlear nerve aplasia, labyrinthine and/or cochlear aplasia are still considered as absolute contraindications, in spite of studies bringing such criteria into question. Cochlear dysplasias constitute relative contraindications, among them labyrinthitis ossificans is highlighted. Other alterations may be mentioned as complicating agents in the temporal bone assessment, namely, hypoplasia of the mastoid process, aberrant facial nerve, otomastoiditis, otosclerosis, dehiscent jugular bulb, enlarged endolymphatic duct and sac. The experienced radiologist assumes an important role in the evaluation of this condition. (author)

  17. Cochlear implant: what the radiologist should know

    Directory of Open Access Journals (Sweden)

    Natalia Delage Gomes

    2013-06-01

    Full Text Available Cochlear implant is the method of choice in the treatment of deep sensorineural hypoacusis, particularly in patients where conventional amplification devices do not imply noticeable clinical improvement. Imaging findings are crucial in the indication or contraindication for such surgical procedure. In the assessment of the temporal bone, radiologists should be familiar with relative or absolute contraindication factors, as well as with factors that might significantly complicate the implantation. Some criteria such as cochlear nerve aplasia, labyrinthine and/or cochlear aplasia are still considered as absolute contraindications, in spite of studies bringing such criteria into question. Cochlear dysplasias constitute relative contraindications, among them labyrinthitis ossificans is highlighted. Other alterations may be mentioned as complicating agents in the temporal bone assessment, namely, hypoplasia of the mastoid process, aberrant facial nerve, otomastoiditis, otosclerosis, dehiscent jugular bulb, enlarged endolymphatic duct and sac. The experienced radiologist assumes an important role in the evaluation of this condition.

  18. Cleidocranial dysplasia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Duk; Lee, Chang Yul; You, Choong Hyun [Chosun University College of Medicine, Gwangju (Korea, Republic of)

    2004-03-15

    Cleidocranial dysplasia is a rare and autosomal dominant disorder characterized by aplasia or hypoplasia of the clavicles, an open fontanelle, dental abnormalities, and short stature. A 17-year-old female who presented with short stature and subsequent delay in eruption of permanent teeth is described. she showed the abnormal hypermobility of the shoulder, ocular hypertelorism and concave nasal bridge. Radiographs revealed the underdeveloped maxilla, defect of the cranium in the fontanelle region, and aplasia of the clavicles. Characteristically, panoramic view revealed near parallel-sided borders of the ascending ramus and downward curvature of the zygomatic arch with hypoplasia. The prolonged retention of deciduous teeth with delayed eruption of permanent teeth and multiple embedded supernumerary teeth were striking. Radiographic and clinical investigations revealed Cleidocranial dysplasia.

  19. Chronic meningitis and central nervous system vasculopathy related to Epstein Barr virus

    Directory of Open Access Journals (Sweden)

    Anil Kumar B Patil

    2012-01-01

    Full Text Available Chronic active Epstein Barr virus (EBV infection causes a wide spectrum of manifestation, due to meningeal, parenchymal and vascular involvement. An 11-year-old boy presented with chronic headache, fever and seizures of 18 months duration. His magnetic resonance imaging Brain showed fusiform aneurysmal dilatations of arteries of both the anterior and posterior cerebral circulation. Cerebrospinal fluid (CSF showed persistent lymphocytic pleocytosis, raised proteins and low sugar with positive polymerase chain reaction for EBV. He later developed pancytopenia due to bone marrow aplasia, with secondary infection and expired. From clinical, imaging and CSF findings, he had chronic lymphocytic meningitis with vasculopathy, which was isolated to the central nervous system. He later had marrow aplasia probably due to X-linked lymphoproliferative disorder related to EBV infection. Vasculopathy, especially diffuse fusiform aneurysmal dilatation associated with chronic EBV infection, is rare, but has been described, similar to our case report.

  20. Autologous reconstruction of a complex form of Poland syndrome using 2 abdominal perforator free flaps.

    Science.gov (United States)

    Masia, Jaume; Pons, Gemma; Loschi, Pietro; Sanchez Porro-Gil, Lidia; Nardulli, Maria Luisa; Olivares, Leyre

    2015-05-01

    Poland syndrome is the most frequent cause of congenital breast aplasia and hypoplasia. Breast and possible chest wall deformities can be treated with several surgical techniques, including implants, and pedicled or free flaps.We describe the case of a young patient with severe Poland syndrome with amastia, athelia, and deformity of the chest wall, and aplasia of 2 ribs. Marked hypoplasia of the ipsilateral latissimus dorsi muscle ruled out a reliable reconstructive option.Two perforator flaps were performed in a single-stage operation. A hemi-deep inferior epigastric perforator flap was harvested to correct the chest deformity, whereas the contralateral superficial inferior epigastric artery flap allowed breast reconstruction.No complications occurred and a subjectively and objectively pleasing cosmetic result was maintained at 3-year follow-up. PMID:24322640

  1. Cretinism revisited

    Directory of Open Access Journals (Sweden)

    Ankit Srivastav

    2012-01-01

    Full Text Available Objective: Cretinism is a condition of severely stunted physical and mental growth due to untreated congenital hypothyroidism. It has been largely eliminated in the developed world, though we still continue to see cases in India. Case Report: A 22-year-old male was brought to our Endocrine clinic by his brother due to his "not growing up." The patient was 83 cm in height (SDS - 16.98 and weighed 13.9 kg (150 IU/ml, free T4 and T3 below the assay range. Ultrasound of neck showed absent thyroid tissue in neck. Iodine-131 uptake scan was consistent with thyroid aplasia. Diagnosis was myxematous cretinism due to thyroid aplasia was made, and patient was started on thyroxine supplementation. Conclusion: This case represents the most severe form of untreated congenital hypothyroidism presenting as severely stunted physical and mental growth with delayed bone and sexual maturation.

  2. Prenatal Diagnosis of Bilateral Ectrodactyly and Radial Agenesis Associated with Trisomy 10 Mosaicism

    OpenAIRE

    Jonathan Lévy; Jean-Marie Jouannic; Julien Saada; Ferdinand Dhombres; Jean-Pierre Siffroi; Marie-France Portnoï

    2013-01-01

    Ectrodactyly or split hand and foot malformations (SHFMs) are rare malformations of the limbs, characterized by median clefts of the hands and feet, syndactyly, and aplasia and/or hypoplasia of the phalanges. They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. Bilateral radial ray defects compris...

  3. Chromosome and p63 Gene Analysis of an Infant with Ectrodactyly–Split Hand and Foot Malformation

    OpenAIRE

    DEMİRHAN, Osman

    2007-01-01

    Aim: Split hand-split foot malformation (SHFM) results from central ray reduction and presents as median clefts of the hands and feet, syndactyly, aplasia or hypoplasia of the phalanges, metacarpals and metatarsals, which are frequently associated with other phenotypic abnormalities. We aimed to investigate the genetic pathway of SHFM in a child. Materials and methods: Cytogenetic and molecular genetic analysis was performed in a 10-day-old boy with split-syndactyly hand and flat-syndactyly...

  4. Three new patients with FATCO: fibular agenesis with ectrodactyly.

    Science.gov (United States)

    Bieganski, Tadeusz; Jamsheer, Aleksander; Sowinska, Anna; Baranska, Dobromila; Niedzielski, Kryspin; Kozlowski, Kazimierz; Czarny-Ratajczak, Malwina

    2012-07-01

    We document three new patients with fibular agenesis, tibial campomelia, and oligosyndactyly (FATCO). Two of these individuals had tetramelic manifestations while the third had bilateral abnormalities of the lower limbs. These patients and others reported as FATCO seem to belong to the phenotype "fibular aplasia with ectrodactyly." Genetic screening for CNVs and mutations in the TP63 and WNT10B genes did not show any genetic abnormalities. © PMID:22628253

  5. MEDICAL MYSTERY: ECTRODACTYLY A CASE REPORT

    OpenAIRE

    Subhra Mandal; Prabir Mandal; Panchanan Kundu

    2015-01-01

    Congenital absence of all or part of one or more fingers or toes is defined as Ectrodactyly. It is the word derived from Greek ektroma meaning “abortion” and dactyly meaning digits. Also called split hand or foot malformation (SHFM), Ectrodactyly is a rare limb malformation with median cleft of hand and foot and aplasia or hypoplasia of the phalanges, metacarpals and metatarsals. Irregular pattern of inheritance exists for ectrodactyly; may be autosomal dominant, autosomal recessive or X link...

  6. Ectrodactyly/split hand feet malformation

    Directory of Open Access Journals (Sweden)

    Jindal Geetanjali

    2009-01-01

    Full Text Available Split-hand/split-foot malformation is a rare limb malformation with median clefts of the hands and feet and aplasia/hypoplasia of the phalanges, metacarpals and metatarsals. When present as an isolated anomaly, it is usually inherited as an autosomal dominant form. We report a case of autosomal recessive inheritance and discuss the antenatal diagnosis, genetic counseling and treatment for the malformation.

  7. Unilateral Ectrodactyly in a Newborn with Trisomy 18 Syndrome: An Unusual Association.

    Science.gov (United States)

    Kislal, Fatih Mehmet; Altuntas, Nilgun; Ozdemir, Osman; Ceylaner, Serdar; Kislal, Mustafa Hayri; Andiran, Nesibe

    2015-08-01

    The case of a newborn male with trisomy 18 syndrome, having bilateral syndactyly, aplasia and hypoplasia of the foot digits, unilateral ectrodactyly of the left foot and a prominently dorsiflexed hallux, clenched hand with overlapping fingers and general hypertonia, is presented. There are only 5 cases of trisomy 18 syndrome associated with ectrodactyly in the literature. We present a case of trisomy 18 syndrome with unilateral ectrodactyly of the left foot, which is an infrequent association. PMID:26305313

  8. Limb mammary syndrome: a new genetic disorder with mammary hypoplasia, ectrodactyly, and other Hand/Foot anomalies maps to human chromosome 3q27.

    OpenAIRE

    Van Bokhoven, H.; Jung, M; Smits, A P; van Beersum, S.; Rüschendorf, F; Van Steensel, M; Veenstra, M; Tuerlings, J.H.; Mariman, E.C.; Brunner, H.G.; Wienker, T. F.; Reis, A.; Ropers, H H; Hamel, B C

    1999-01-01

    We report on a large Dutch family with a syndrome characterized by severe hand and/or foot anomalies, and hypoplasia/aplasia of the mammary gland and nipple. Less frequent findings include lacrimal-duct atresia, nail dysplasia, hypohydrosis, hypodontia, and cleft palate with or without bifid uvula. This combination of symptoms has not been reported previously, although there is overlap with the ulnar mammary syndrome (UMS) and with ectrodactyly, ectodermal dysplasia, and clefting syndrome. Al...

  9. Familial Ectrodactyly Syndrome in a Nigerian Child: A Case Report

    OpenAIRE

    Abdulrasheed Adegboye; Olugbenga Ayodeji Mokuolu; Samuel Kolade Ernest; Omotayo Adesiyun; Adeline Adaje; Sefiyah Yahaya-Kongoila; Muhammed Adeboye; Mathew Durowaye

    2011-01-01

     Ectrodactyly, also known as Split-Hand/Split-Foot Malformation (SHFM) is a rare genetic condition characterized by defects of the central elements of the autopod. It has a prevalence of 1:10,000-1:90,000 worldwide. The X-linked and autosomal dominant types have been described. It can occur as an isolated malformation or in combination with other anomalies, such as tibial aplasia, craniofacial defects, and genitourinary abnormalities. Ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC) ...

  10. Thymoma followed by aplastic anemia: two different responses to immunosuppressive therapy

    OpenAIRE

    Murilo Antunes de Castro; Mariana Antunes de Castro; Adriano de Moraes Arantes; Maria do Rosário Ferraz Roberti

    2011-01-01

    Aplastic anemia is an uncommon complication of thymoma and is extremely infrequent after the surgical removal of a thymic tumor. Aplastic anemia is a result of marrow failure and is characterized by peripheral pancytopenia and severely depressed marrow cellularity; it may be an autoimmune manifestation of thymoma. As thymoma-associated hematological dyscrasias, which include pure red cell aplasia, aplastic anemia and myasthenia gravis, are supposed to be of immunologic origin, two cases of ve...

  11. Multifocal Aeromonas Osteomyelitis in a Child with Leukemia

    OpenAIRE

    Doganis, Dimitrios; Baka, Margarita; Tsolia, Maria; Pourtsidis, Apostolos; Lebessi, Evangelia; Varvoutsi, Maria; Bouhoutsou, Despina; Kosmidis, Helen

    2016-01-01

    Aeromonas hydrophila is a Gram negative organism causing both intestinal and extraintestinal disease. The case of a 14-year-old girl with underlying immunodeficiency and leukemia who developed systemic A. hydrophila infection is described in this report. While in deep bone marrow aplasia she developed fever, severe pain in the lower extremities, and swelling of the left femur. Blood culture showed Escherichia coli and A. hydrophila whereas pus culture from the soft tissue swelling showed the ...

  12. Intestinal acute graft versus host disease

    OpenAIRE

    Rovani, C; Danse, E; Dragean, C

    2010-01-01

    Background: We present a case of a 23-year-old man having drug addiction. He is managed by the department of hematology for an idiopathic medullar aplasia. Two months before his admission, he was treated with bone marrow transplantation. During follow-up, we noted a nonspecific recent cutaneous lesion. He was admitted for acute digestive symptoms including anorexia, nausea, vomiting and abdominal pain.

  13. BIZARRE CASE OF POLYDACTYLY WITH RIGHT MIRROR FOOT

    Directory of Open Access Journals (Sweden)

    Saif Omar

    2014-06-01

    Full Text Available Mirror foot, a form of polydactyly, is a rare congenital anomaly. In this form of congenital anomaly, there are several additional digits with accessory tarsal bones. It may be associated with fibular dimelia, tibial aplasia and tibial dysplasia. Cause of such anomaly is not known. On experimental basis it appears to involve ectopic SHH (Sonic hedgehog signaling in the limb bud mesenchyme

  14. Anomalies and developmental defects

    International Nuclear Information System (INIS)

    Amonalies and developmental defects in trachea and bronchi (tracheal bronch us, diverticulum of trachea or bronchus, defects due to atresia of bronchial tre e, tracheobronchomegaly), lung vessels (aneurisms of pulmonary artery, agenesia, aplasia and hypoplasia of pulmonary artery,anomalies of pulmonary veins, varico sis of pulmonary veins), pulmonary tissue (lung sequestration, congenital lobar pulmonary emphysema, essential hemosiderosis), have beendescribed. The problems of the diagnosis of the above-mentioned diseases using roentgenograms are consid ered

  15. Radiographic findings in the nail-patella syndrome

    OpenAIRE

    West, James A.; Louis, Thomas H.

    2015-01-01

    Nail-patella syndrome is a rare disorder characterized classically by the tetrad of nail hypoplasia or aplasia, aplastic or hypoplastic patellae, elbow dysplasia, and the presence of iliac horns. Iliac horns are considered pathognomonic, and the presence of hypoplastic or aplastic patellae in conjunction with nail abnormalities is a cardinal feature of diagnosis. Elbow dysplasia is present in most cases and can exhibit features typical of the syndrome. Herein we present the radiographic findi...

  16. Johanson-Blizzard syndrome with Diamond-Blackfan anemia.

    Science.gov (United States)

    Saeed, Muhammad; Rana, Muhammad Nasir; Ahmad, Tahir Masood

    2010-09-01

    Johanson Blizzard syndrome (JBS) is a rare multi-system disorder characterized by congenital aplasia or hypoplasia of alae nasi, exocrine pancreatic insufficiency, hypothyroidism, deafness, growth retardation, varying degree of mental retardation, alopecia, wide open fontanels, anti-mongoloid slant, café-au-lait spots and absent of permanent teeth. We report a 3 months old male child having Johanson Blizzard syndrome with classical clinical features, pancreatic insufficiency and Diamond-Blackfan anemia. PMID:20810061

  17. A pedigree study of perinatally lethal renal disease.

    OpenAIRE

    Bankier, A; de Campo, M; Newell, R.; Rogers, J. G.; Danks, D M

    1985-01-01

    A family study of perinatally lethal renal disease (PLRD) was undertaken in the State of Victoria, Australia, for the years 1961 to 1980. A total of 221 cases was ascertained through hospital and necropsy records and confirmed by necropsy findings. There were 134 cases of bilateral renal agenesis (BRA), 34 cases of unilateral agenesis with dysplasia of the other kidney (URA/RD), 42 cases of bilateral renal dysplasia (BRD), and 11 cases of renal aplasia. Parents of 131 babies were interviewed ...

  18. Bilateral Carotid and Vertebral Rete Mirabile Presenting with a Prominent Anterior Spinal Artery Mimicking a Spinal Dural AV Fistula at MRI

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Seung Young; Cha, Sang Hoon [Chungbuk National University College of Medicine, Iksan (Korea, Republic of)

    2011-11-15

    Bilateral carotid and vertebral rete mirabile (CVRM) is a very rare condition. We report a new case of CVRM initially detected by magnetic resonance imaging (MRI) of the cervical spine. MRI demonstrated tortuous vascular signal voids limited to the anterior cerebrospinal fluid space mimicking spinal dural arteriovenous fistula. A diagnosis of CVRM was confirmed on the basis of angiographic findings of rete formation associated with bilateral aplasia of the cavernous internal carotid and vertebral arteries without abnormal arteriovenous connection.

  19. Revisiting the craniosynostosis‐radial ray hypoplasia association: Baller‐Gerold syndrome caused by mutations in the RECQL4 gene

    OpenAIRE

    Van Maldergem, L; Siitonen, H. A; Jalkh, N.; Chouery, E; Roy, M.; Delague, V; Muenke, M; Jabs, E W; J. Cai; Wang, L. L.; Plon, S E; Fourneau, C.; Kestilä, M.; Gillerot, Y; Mégarbané, A

    2005-01-01

    Baller‐Gerold syndrome (BGS) is a rare autosomal recessive condition with radial aplasia/hypoplasia and craniosynostosis (OMIM 218600). Of >20 cases reported so far, a few appear atypical and have been reassigned to other nosologic entities, including Fanconi anaemia, Roberts SC phocomelia, and Pfeiffer syndromes after demonstration of corresponding cytogenetic or molecular abnormalities. Clinical overlap between BGS, Rothmund‐Thomson syndrome (RTS), and RAPADILINO syndrome is noticeable. Bec...

  20. A gene for cleidocranial dysplasia maps to the short arm of chromosome 6.

    OpenAIRE

    Feldman, G.J.; Robin, N.H.; Brueton, L.A.; Robertson, E.; Thompson, E. M.; Siegel-Bartelt, J; Gasser, D L; Bailey, L C; Zackai, E. H.; Muenke, M

    1995-01-01

    Cleidocranial dysplasia (CCD) is an autosomal dominant generalized bone dysplasia characterized by mild-to-moderate short stature, clavicular aplasia or hypoplasia, supernumerary and ectopic teeth, delayed eruption of secondary teeth, a characteristic craniofacial appearance, and a variety of other skeletal anomalies. We have performed linkage studies in five families with CCD, with 24 affected and 20 unaffected individuals, using microsatellite markers spanning two candidate regions on chrom...

  1. Conservative Treatment of a Patient with Epidermolysis Bullosa Presenting as Bart Syndrome: A Case Report

    OpenAIRE

    2010-01-01

    We presented a case of a newborn male with aplasia cutis congenita on the lower limb. The case was treated with conservative method. As for the conservative treatment, daily hydrodebridement with 1/200 diluted povidone-iodine and serum physiologic was performed, followed by closure of the wound with a dexpanthenol + chlorhexidine + fusidic acid-impregnated sterile gauze bandage. the followup that occured after three weeks, the wound was completely epithelialized, but a hypopigmented scar rema...

  2. Quantitative analytical technique applied to histopathology of birds infected experimentally by the virus of chicken anemia virus

    OpenAIRE

    García, Luz; Bermudez, Victor; Brett, Mariela; Peroza, Luzmila; Landa, Juan de; Borregales, Franklin

    2008-01-01

    This research was conducted on ten glass slides selected from the histopathology evaluation chickens. Five slides of control's chickens healthy and five slides of chickens infected experimentally with chicken anemia virus (CAV slide) between one and twenty-one days post infection (PI), they were analyzed in magnifications of 200× and 400×. Histopathology showed severe bone marrow hypoplasia to complete aplasia, fully depletion of the erythrocytic and granulocytic series, both accompanied by s...

  3. Quantitative analytical technique applied to histopathology of birds infected experimentally by the virus of chicken anemia virus

    OpenAIRE

    Landa Juan; Peroza Luzmila; Brett Mariela; Bermudez Victor; García Luz; Borregales Franklin

    2008-01-01

    Abstract This research was conducted on ten glass slides selected from the histopathology evaluation chickens. Five slides of control's chickens healthy and five slides of chickens infected experimentally with chicken anemia virus (CAV slide) between one and twenty-one days post infection (PI), they were analyzed in magnifications of 200× and 400×. Histopathology showed severe bone marrow hypoplasia to complete aplasia, fully depletion of the erythrocytic and granulocytic series, both accompa...

  4. Hematopoietic Stem Cell Transplantation—50 Years of Evolution and Future Perspectives

    OpenAIRE

    Israel Henig; Tsila Zuckerman

    2014-01-01

    Hematopoietic stem cell transplantation is a highly specialized and unique medical procedure. Autologous transplantation allows the administration of high-dose chemotherapy without prolonged bone marrow aplasia. In allogeneic transplantation, donor-derived stem cells provide alloimmunity that enables a graft-versus-tumor effect to eradicate residual disease and prevent relapse. The first allogeneic transplantation was performed by E. Donnall Thomas in 1957. Since then the field has evolved an...

  5. Bilateral Carotid and Vertebral Rete Mirabile Presenting with a Prominent Anterior Spinal Artery Mimicking a Spinal Dural AV Fistula at MRI

    International Nuclear Information System (INIS)

    Bilateral carotid and vertebral rete mirabile (CVRM) is a very rare condition. We report a new case of CVRM initially detected by magnetic resonance imaging (MRI) of the cervical spine. MRI demonstrated tortuous vascular signal voids limited to the anterior cerebrospinal fluid space mimicking spinal dural arteriovenous fistula. A diagnosis of CVRM was confirmed on the basis of angiographic findings of rete formation associated with bilateral aplasia of the cavernous internal carotid and vertebral arteries without abnormal arteriovenous connection.

  6. Scientific works of research workers of the army health service

    International Nuclear Information System (INIS)

    Ten articles about the effects of gamma radiation on human or animal cells are studied here. Regulation of cytokines, effect of interleukin 6, expression of the C-fos protein, interest of the study of a biological check up after an accidental irradiation, interaction and transport of cysteamine( radioprotector), approach of a treatment of radioinduced medullary aplasia, expression of TNF alpha and gelatinase B, are the subjects related here. (N.C.)

  7. A complex microdeletion 17q12 phenotype in a patient with recurrent de novo membranous nephropathy

    Directory of Open Access Journals (Sweden)

    Hinkes Bernward

    2012-05-01

    Full Text Available Abstract Background Microdeletions on chromosome 17q12 cause of diverse spectrum of disorders and have only recently been identified as a rare cause of Mayer-Rokitansky-Kuester-Hauser-Syndrome (MRKH, which is characterized by uterus aplasia ± partial/complete vaginal aplasia in females with a regular karyotype. For the first time we report about a patient with a 17q12 microdeletion who is affected by MRKH in combination with a vascular and soft tissue disorder. Repeatedly she suffered from kidney transplant failure caused by consuming membranous nephropathy. Case presentation A 38-year-old female patient had been diagnosed with right kidney aplasia, left kidney dysplasia and significantly impaired renal function during infancy. Aged 16 she had to start hemodialysis. Three years later she received her first kidney transplant. Only then she was diagnosed with MRKH. The kidney transplant was lost due to consuming nephrotic syndrome caused by de novo membranous nephropathy, as was a second kidney transplant years later. In addition, a hyperelasticity syndrome affects the patient with congenital joint laxity, kyphoscoliosis, bilateral hip dysplasia, persistent hypermobility of both elbows, knees and hips. Her clinical picture resembles a combination of traits of a hypermobile and a vascular form of Ehlers-Danlos-Syndrome, but no mutations in the COL3A1 gene was underlying. Instead, array-based comparative genomic hybridisation (CGH detected a heterozygous 1.43 Mb deletion on chromosome 17q12 encompassing the two renal developmental genes HNF1β and LHX1. Conclusions Deletions of HNF1β have recently drawn significant attention in pediatric nephrology as an important cause of prenatally hyperechogenic kidneys, renal aplasia and renal hypodysplasia. In contrast, membranous nephropathy represents an often-unaccounted cause of nephrotic syndrome in the adult population. A causative connection between theses two conditions has never been postulated, but

  8. The Baller-Gerold syndrome.

    OpenAIRE

    Maldergem, L. van; Verloes, A.; Lejeune, L.; Gillerot, Y.

    1992-01-01

    A case of severe craniosynostosis-radial aplasia (Baller-Gerold) syndrome is described in a newborn male, following a pregnancy complicated by polyhydramnios and intrauterine growth retardation. Death occurred after two hours owing to a prolonged apnoeic spell. Extensive agenesis of the frontal and parietal bones, resulting in a very large fontanelle, in addition to coronal bilateral craniosynostosis was observed at necropsy. There was also bilateral radial agenesis, oligodactyly of the hands...

  9. Johanson-Blizzard syndrome

    OpenAIRE

    2011-01-01

    Johanson-Blizzard syndrome (JBS) is a rare autosomal recessive disease characterized by exocrine pancreatic insufficiency, hypoplastic or aplastic nasal alae, cutis aplasia on the scalp, and other features including developmental delay, failure to thrive, hearing loss, mental retardation, hypothyroidism, dental abnormalities, and anomalies in cardiac and genitourinary systems. More than 60 cases of this syndrome have been reported to date. We describe the case of a male infant with typical sy...

  10. Prenatal diagnosis and molecular cytogenetic analysis of a de novo isodicentric chromosome 18

    OpenAIRE

    Zhang Yanliang; Dai Yong; Ren Jinghui; Wang Linqian

    2010-01-01

    Isodicentric chromosome 18 [idic(18)] is rare structural aberration. We report on a prenatal case described by conventional and molecular cytogenetic analyses. The sonography at 24 weeks of gestation revealed multiple fetal anomalies; radial aplasia and ventricular septal defect were significant features. Routine karyotyping showed a derivative chromosome replacing one normal chromosome 18. The parental karyotypes were normal, indicating that the derivative chromosome was de novo. Array compa...

  11. Prenatal diagnosis and molecular cytogenetic analysis of a de novo isodicentric chromosome 18

    OpenAIRE

    Zhang, Yanliang; Dai, Yong; Ren, Jinghui; Wang, Linqian

    2010-01-01

    Isodicentric chromosome 18 [idic(18)] is rare structural aberration. We report on a prenatal case described by conventional and molecular cytogenetic analyses. The sonography at 24 weeks of gestation revealed multiple fetal anomalies; radial aplasia and ventricular septal defect were significant features. Routine karyotyping showed a derivative chromosome replacing one normal chromosome 18. The parental karyotypes were normal, indicating that the derivative chromosome was de novo. Array compa...

  12. Proboscis Lateralis of Nose—A Case Report

    OpenAIRE

    Magadum, Sunil Bajarang; Khairnar, Prashant; Hirugade, Shivprasad; Kassa, Vijay

    2011-01-01

    Lateral proboscis is a rare craniofacial malformation characterized by a rudimentary tubular, nose-like structure located off-center from the vertical midline of the face, and occur in association with a wide spectrum of other anomalies, including heminasal aplasia spectrum,mental retardation, callosal agenesis, heminasal hypoplasia, microphthalmia, and atypical clefting syndrome. Evaluation of a patient should include CT scan examination to look for growth of facial and skull bones. Reconstr...

  13. In-Depth, Label-Free Analysis of the Erythrocyte Cytoplasmic Proteome in Diamond Blackfan Anemia Identifies a Unique Inflammatory Signature

    OpenAIRE

    Esther N Pesciotta; Ho-Sun Lam; Andrew Kossenkov; Jingping Ge; Showe, Louise C.; Mason, Philip J.; Monica Bessler; Speicher, David W.

    2015-01-01

    Diamond Blackfan Anemia (DBA) is a rare, congenital erythrocyte aplasia that is usually caused by haploinsufficiency of ribosomal proteins due to diverse mutations in one of several ribosomal genes. A striking feature of this disease is that a range of different mutations in ribosomal proteins results in similar disease phenotypes primarily characterized by erythrocyte abnormalities and macrocytic anemia, while most other cell types in the body are minimally affected. Previously, we analyzed ...

  14. Scientific works of research workers of the army health service; Travaux scientifiques des chercheurs du service de sante des armees

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    Ten articles about the effects of gamma radiation on human or animal cells are studied here. Regulation of cytokines, effect of interleukin 6, expression of the C-fos protein, interest of the study of a biological check up after an accidental irradiation, interaction and transport of cysteamine( radioprotector), approach of a treatment of radioinduced medullary aplasia, expression of TNF alpha and gelatinase B, are the subjects related here. (N.C.).

  15. Hematopoietic Defects in rps29 Mutant Zebrafish Depend Upon p53 Activation

    OpenAIRE

    Taylor, Alison Marie; Humphries, Jessica M.; White, Richard; Murphey, Ryan D.; Burns, Caroline Erter; Zon, Leonard Ira

    2012-01-01

    Disruption of ribosomal proteins is associated with hematopoietic phenotypes in cell culture and animal models. Mutations in ribosomal proteins are seen in patients with Diamond Black- fan anemia, a rare congenital disease characterized by red cell aplasia and distinctive cranio- facial anomalies. A zebrafish screen uncovered decreased hematopoietic stem cells in embryos with mutations in ribosomal protein rps29. Here, we determined that rps29L/L embryos also have red blood cell defects and i...

  16. Conservative Treatment of a Patient with Epidermolysis Bullosa Presenting as Bart Syndrome: A Case Report

    Directory of Open Access Journals (Sweden)

    Samet Vasfi Kuvat

    2010-01-01

    Full Text Available We presented a case of a newborn male with aplasia cutis congenita on the lower limb. The case was treated with conservative method. As for the conservative treatment, daily hydrodebridement with 1/200 diluted povidone-iodine and serum physiologic was performed, followed by closure of the wound with a dexpanthenol + chlorhexidine + fusidic acid-impregnated sterile gauze bandage. the followup that occured after three weeks, the wound was completely epithelialized, but a hypopigmented scar remained in the limb.

  17. PCI-32765, the First BTK (Bruton’s Tyrosine Kinase) Inhibitor in Clinical Trials

    OpenAIRE

    Brown, Jennifer R

    2013-01-01

    Ibrutinib is a potent covalent kinase inhibitor that targets BTK. BTK, or Bruton’s tyrosine kinase, is an obvious target for therapy of B cell diseases because inactivating mutations lead to B cell aplasia in humans and the disease X-linked agammaglobulinemia. Ibrutinib has modest cytotoxicity against CLL cells in vitro but also blocks trophic stimuli from the microenvironment. As with other inhibitors of the BCR pathway, ibrutinib causes rapid nodal reduction and response associated with rap...

  18. Parvovirus-induced dyserythropoeisis in a child

    Directory of Open Access Journals (Sweden)

    Jain Deepali

    2008-07-01

    Full Text Available Most persons with parvovirus B19 infection are asymptomatic or exhibit mild, nonspecific, cold-like symptoms. However, hematologic problems associated with the infection include transient aplastic crisis, chronic red cell aplasia, mild neutropenia and thrombocytopenia. A rare hematologic manifestation is in the form of dyserythropoeisis. Herein, we present the case of a 9-year-old female with severe dyserythropoeisis associated with parvovirus infection.

  19. Quantitative analysis of human herpesvirus-6 genome in blood and bone marrow samples from Tunisian patients with acute leukemia: a follow-up study

    OpenAIRE

    Faten, Nefzi; Agnès, Gautheret-Dejean; Nadia, Ben Fredj; Nabil, Abid Ben Salem; Monia, Zaier; Abderrahim, Khelif; Henri, Agut; Salma, Feki; Mahjoub, Aouni

    2012-01-01

    Background Infectious etiology in lymphoproliferative diseases has always been suspected. The pathogenic roles of human herpesvirus-6 (HHV-6) in acute leukemia have been of great interest. Discordant results to establish a link between HHV-6 activation and the genesis of acute leukemia have been observed. The objective of this study was to evaluate a possible association between HHV-6 infection and acute leukemia in children and adults, with a longitudinal follow-up at diagnosis, aplasia, rem...

  20. Congenital deformities and developmental abnormalities of the mandibular condyle in the temporomandibular joint.

    Science.gov (United States)

    Kaneyama, Keiseki; Segami, Natsuki; Hatta, Toshihisa

    2008-09-01

    The temporomandibular joint (TMJ) consists of the mandibular condyle and the articular eminence of the temporal bone. The morphological development of the TMJ during prenatal life lags behind other joints in terms of both the timing of its appearance and its progress. At birth, the joint is still largely underdeveloped. There are many causes of the various growth disturbances and abnormalities of the mandibular condyle and related structures. Growth disturbances in the development of the mandibular condyle may occur in utero late in the first trimester and may result in disorders such as aplasia or hypoplasia of the mandibular condyle. Meanwhile, hyperplasia of the mandibular condyle is not visible at birth and seems to be gradually acquired during growth. In the present review article, the congenital abnormalities of the mandibular condyle are classified morphologically into three major groups and two subgroups from a clinical standpoint: (1) hypoplasia or aplasia of the mandibular condyle, including (i) primary condylar aplasia and hypoplasia, (ii) secondary condylar hypoplasia; (2) hyperplasia; and (3) bifidity. In addition, the molecular-based etiology of anomalies of the mandibular condyle is also discussed. PMID:18778456

  1. Aplastic crisis due to human parvovirus B19 infection in hereditary hemolytic anaemia Crise aplástica devido à infecção por parvovirus humano B19 em anemia hemolítica hereditária

    Directory of Open Access Journals (Sweden)

    R. C. N. Cubel

    1992-10-01

    Full Text Available Specific anti-B19 IgM was demonstrated in sera from three children showing transient aplastic crisis. A two years-old boy living in Rio de Janeiro suffering from sickle-cell anaemia showed the crisis during August, 1990. Two siblings living in Santa Maria, RS, developed aplastic crisis during May, 1991, when they were also diagnosed for hereditary spherocytosis. For a third child from this same family, who first developed aplastic crisis no IgM anti-B19 was detected in her sera.IgM específica anti-B19 foi demonstrada nos soros de três crianças apresentando aplasia transitória de medula. Um menino de dois anos de idade vivendo no Rio de Janeiro e sendo portador de anemia falciforme, apresentou a crise durante Agosto de 1990. Dois irmãos vivendo em Santa Maria - RS, desenvolveram crise de aplasia em Maio de 1991, quando foram também diagnosticados como portadores de microesferocitose. IgM anti-B19 não foi detectada no soro de uma terceira criança, desta mesma família, a qual primeiramente apresentou crise de aplasia.

  2. Medical management of accidentally exposed individuals

    International Nuclear Information System (INIS)

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Whilst transfusion and bone marrow transplantation have been used with some success starting with the first treatments of accident victims, other therapeutic strategies are needed. With the development of experimental and clinical haematology, promising new approaches to the treatment of aplasia have appeared. New trends for the treatment of haemopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. Haemopoietic growth factors stimulate the proliferation and/or differentiation of haemopoietic progenitors and, possibly, stem cells. Furthermore, they act on the functions of mature cells. Currently, they have specific uses in haematology related to their role in the regulation of growth and in the differentiation of haemopoietic progenitor cells. Growth factors have already been used for the treatment of accidental radiation induced aplasia and lessons have been learned from their medical management and followup. (author)

  3. Unilateral dysgenesis of the internal carotid artery: spectrum of imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    De Mendonca, J.L.F.; Viana, S.L.; Freitas, F.M.O.; Matos, V.L. [Magnetic Resonance Dept., Clinica Radiologica Vila Rica, Brasilia (Brazil)], E-mail: radiolog@uol.com.br; Viana, M.A.C.B. [Hospital de Base do Distrito Federal, Brasilia (Brazil); Silva, R.F. [Diagnostik, Hospital das Clinicas de Brasilia, Brasilia (Brazil); Quaglia, L.A.N. [Hospital Santa Lucia, Brasilia (Brazil); Guerra, J.G. [Hospital Regional de Taguatinga, Brasilia (Brazil)

    2008-04-15

    Dysgenesis of the internal carotid artery (ICA) is a broad term comprising hypoplasia, aplasia and agenesis of the vessel. It is a rare anomaly, often clinically silent, that can be confidently diagnosed by means of noninvasive imaging methods. After a review of teaching files, 7 patients with unilateral carotid dysgenesis were found, 2 with agenesis of the ICA, 3 with carotid aplasia, and 2 with hypoplasia of the vessel. Computed tomography (CT) and magnetic resonance angiography (MRA) of the brain were performed in all patients, with a complete magnetic resonance of the brain in 3 of them, a CT angiography of the brain in one, and MRA of the cervical arteries in 3. The fetal pattern of arterial circulation was found in 3 patients with agenesis/aplasia of the ICA and the adult pattern was found in 2 patients, being the brain circulation of normal pattern in the patients with hypoplasia of the ICA. Two patients presented signs of reduced flow to the brain hemisphere ipsilateral to the carotid dysgenesis; one of them with an old homolateral brain infarction. Far from being just an anatomic curiosity, the dysgenesis of the ICA may have serious consequences if not recognized prior to endarterectomies, carotid ligation or transsphenoidal surgery. As much as one-third of these patients will have intracranial aneurysms as well. The imaging methods, instead being mutually exclusive, are complementary in the evaluation of carotid dysgenesis. (author)

  4. Unilateral dysgenesis of the internal carotid artery: spectrum of imaging findings

    International Nuclear Information System (INIS)

    Dysgenesis of the internal carotid artery (ICA) is a broad term comprising hypoplasia, aplasia and agenesis of the vessel. It is a rare anomaly, often clinically silent, that can be confidently diagnosed by means of noninvasive imaging methods. After a review of teaching files, 7 patients with unilateral carotid dysgenesis were found, 2 with agenesis of the ICA, 3 with carotid aplasia, and 2 with hypoplasia of the vessel. Computed tomography (CT) and magnetic resonance angiography (MRA) of the brain were performed in all patients, with a complete magnetic resonance of the brain in 3 of them, a CT angiography of the brain in one, and MRA of the cervical arteries in 3. The fetal pattern of arterial circulation was found in 3 patients with agenesis/aplasia of the ICA and the adult pattern was found in 2 patients, being the brain circulation of normal pattern in the patients with hypoplasia of the ICA. Two patients presented signs of reduced flow to the brain hemisphere ipsilateral to the carotid dysgenesis; one of them with an old homolateral brain infarction. Far from being just an anatomic curiosity, the dysgenesis of the ICA may have serious consequences if not recognized prior to endarterectomies, carotid ligation or transsphenoidal surgery. As much as one-third of these patients will have intracranial aneurysms as well. The imaging methods, instead being mutually exclusive, are complementary in the evaluation of carotid dysgenesis. (author)

  5. Medical management of accidentally exposed individuals

    International Nuclear Information System (INIS)

    Bone marrow aplasia is one of the main syndromes following a high dose accidental radiation exposure. Although both transfusion and bone marrow transplantation have been used with some success since the first treatments of patients, other therapeutic strategies are needed. New promising approaches of the treatment of aplasia have appeared with the development of experimental and clinical hematology. Some new trends for the treatment of the hematopoietic injury based on bone marrow transplantation rely on new sources of compatible donor cells, such as cord blood, on the selection of immature haemopoietic cells and on new transplant regimens. The hematopoietic growth factors stimulate proliferation and/or differentiation of hematopoietic progenitors and possibly stem cells. Furthermore, they act on the functions of mature cells. They have now specific uses in hematology, related to their role in the regulation of growth and differentiation of hematopoietic progenitor cells. Some growth factors have already been used for the treatment of accidental radiation-induced aplasia and lessons have been learned from their medical management and follow-up. (author)

  6. Some examples of the use of radioactive tracers in pharmacodynamic; Quelques exemples de l'emploi des traceurs radioactifs en pharmacodynamie

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    The study of absorption, of distribution in the organism and of the elimination of a medicament has been greatly facilitated by the development of nuclear applications. In effect, the introduction into the molecule of one or several radioactive atoms makes it possible to follow the path and destination of minute quantities of the drug and to thus carry out analyses on the animal within limits of posology close to those of therapeutics. However the qualitative or quantitative methods used have certain limits and they must be compared amongst themselves and with others. Some examples will show : - the importance of the way of administering the drug on the changes in the distribution; - the quite relative selectivity of this latter; - and lastly, the different process involved in the elimination mechanisms. (author) [French] L'etude de l'absorption, de la repartition dans l'organisme et de l'elimination d'un medicament s'est trouvee grandement facilitee par le developpement des applications nucleaires. En effet, l'introduction dans une molecule d'un ou plusieurs atomes radioactifs permet de suivre le sort de quantites infimes de la drogue et de ce fait d'en effectuer l'analyse chez l'animal dans des limites de posologie se rapprochant de celles de la therapeutique. Cependant les methodes employees, qualitatives ou quantitatives, presentent des limites et doivent etre confrontees entre elles et avec d'autres methodes. Quelques exemples mettront en evidence: - l'importance du mode d'administration sur l'evolution de la repartition, - l'electivite toute relative de cette derniere, - et enfin, les modalites diverses des mecanismes d'elimination. (auteur)

  7. Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks. From Contamination Analysis to the Collective Whistle-Blowing Process Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des ÉPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    OpenAIRE

    Alain Garrigou; Isabelle Baldi; Philippe Dubuc

    2008-01-01

    This paper presents the results of an ergotoxicologic study on the effectiveness, in real-life conditions, of the protective suits recommended by preventionists. The arguments presented in the paper are based on the Pestexpo study conducted by Isabelle Baldi (Baldi et al. (2002) and Baldi et al. (2006)), which involved analyzing the exposure of vineyard workers to plant protection products by using an ergo-toxicologic approach. The point is to identify different types of exposure by taking in...

  8. Apports de l’ergotoxicologie à l’évaluation de l’efficacité réelle des EPI devant protéger du risque phytosanitaire : de l’analyse de la contamination au processus collectif d’alerte Contribution of Ergotoxicology to the Determination of Actual PPE Effectiveness in Protecting Users From Phytosanitary Risks:From Contamination Analysis to the Collective Whistle-Blowing Process Aportes de la ergotoxicoliogía a la evaluación de la eficacia real de los epi destinados a proteger del riesgo fitosanitario : del análisis de la contaminación al proceso colectivo de alerta

    OpenAIRE

    Alain Garrigou; Isabelle Baldi; Philippe Dubuc

    2008-01-01

    L’objectif de cet article est de présenter des résultats récents d’une recherche/action en ergotoxicologie concernant les risques liés à l’usage des produits phytosanitaires. Cette recherche propose une double articulation : la première entre des résultats issus d’analyses en situations de travail portant sur la contamination externe des viticulteurs et des résultats issus de tests en laboratoire portant sur la perméation des combinaisons. La seconde articulation concerne le lien entre l’ense...

  9. Mieux assumer les paradoxes d’une formation professionnelle et universitaire des enseignants d’éducation musicale : analyse de quelques « notions fondamentales » au regard des idéologies de la nature-source

    OpenAIRE

    GUIRARD, laurent

    2011-01-01

    International audience L’éducation musicale souffre d’une difficulté didactique courante mais possiblement aggravée par son statut d’art d’agrément : le manque d’accord entre une pratique de terrain que peut légitimement gouverner un critère d’efficacité relativement autonome (les élèves font ou entendent de la musique et en éprouveraient « simplement du plaisir »), et des outils théoriques épars qui permettraient de comprendre ou d’éclairer cette pratique à partir d’une position d’autorit...

  10. La recherche pour l'innovation ou l'innovation pour la recherche? Le développement du photovoltaïque en Polynésie

    OpenAIRE

    Akrich, Madeleine

    1988-01-01

    National audience A partir d'une étude de cas, l'implantation d'un programme d'électrification photovoltaïque en Polynésie, cet article s'interroge sur rôle de la recherche dans l'innovation industrielle: on montre que, dans ce cas particulier, cela revient à se poser la question de l'efficacité relative des multiples moyens d'accès au "réel" dont disposent les innovateurs pour ajuster la forme de l'objet technique au milieu auquel il est destiné. L'effort de description porte sur la resti...

  11. L’utilisation de certains exercices de Brain Gym peut-elle aider certains élèves à mieux mémoriser?

    OpenAIRE

    Descloux, Nadine; Bachmann, Marine; Lentillon-Kaestner, Vanessa

    2016-01-01

    Lorsque nous travaillons longuement, il arrive un moment où nous devenons moins efficace. Mais heureusement, on peut se lever et bouger. Aujourd’hui, les enfants vivent dans la génération « zapping » et sont demandeurs de mouvements. En tant qu’enseignant, nous avons à disposition divers outils qui permettent aux élèves de se focaliser sur leur travail. Nous avons choisi de tester l’efficacité de la Brain Gym, la mise en pratique de cette méthode a pour objectif d’aider les élèves à se recent...

  12. L'acide linoléique conjugué en nutrition porcine

    OpenAIRE

    C. Corino; G. Pastorelli; Douard, Véronique; Rossi, R; MUSELLA, M.; Mourot, Jacques

    2006-01-01

    Les CLA ont plusieurs effets biologiques intéressants vis-à-vis de la santé : ils ont une propriété anticarcinogène, une activité anti-athérosclérose et antioxydante. Ils diminuent l’obésité et apparaissent comme un facteur capable de stimuler la réponse immunitaire. En nutrition porcine, l’influence sur les performances de croissance est limitée et on peut observer seulement un faible effet positif sur l’efficacité alimentaire. La composition corporelle et les paramètres de la qualité de la ...

  13. Photography as diagnosis of contemporaneity

    OpenAIRE

    Dondero, Maria Giulia

    2006-01-01

    Cet article porte sur l’efficacité politique d’une série photographique qui problématise des questions socioculturelles contemporaines telles l’immigration, l’exploitation et l’éthique du travail. L’image photographique devient une ressource dans les mains des acteurs sociaux et fait fonction de diagnostic des tensions du contemporain. La photographie permet de «reconnaître à travers» (c’est-à-dire « diagnostiquer ») et de formuler des jugements. Le potentiel sémantique du diagnostic engendré...

  14. Le marketing responsable, un outil de management de la qualité et de promotion de l'innovation responsable

    OpenAIRE

    BARTHEL, Patrick

    2013-01-01

    L'objectif de ce papier est de décrire brièvement le modèle d'un marketing responsable élaboré sur la base de nombreuses études empiriques auprès de consommateurs et de responsables d'entreprise ; il vise surtout à montrer en quoi une telle orientation marketing participe de l'efficacité du management de la qualité tout en favorisant la promotion de l'innovation, et plus précisément l'innovation dite responsable.

  15. ANALYSE DE L'ENCODAGE DES SIGNAUX DE PAROLE DANS LE TRONC CEREBRAL (SPEECH AUDITORY BRAINSTEM RESPONSE)

    OpenAIRE

    Akhoun, Idrick

    2008-01-01

    Les Speech ABR sont un outil prometteur d'exploration fonctionnelle auditive, qui pourrait à terme être implémenté en routine clinique afin de dépister la surdité et d'évaluer l'efficacité des techniques de réhabilitation auditive. Dans la Partie 1, nous présentons d'abord (i) une étude paramétrique quantifiant les effets de l'artefact électromagnétique, issu du couplage entre la chaine de stimulation et d'acquisition, sur le Speech ABR. Puis nous discutons (ii) les avantages de la représenta...

  16. Chapitre V. Moderniser la régie des Contributions indirectes 1959-1962

    OpenAIRE

    2014-01-01

    Ma première mission à la DGI se situe dans les services des contributions indirectes. Robert Blot m’avait fixé un programme précis : moderniser cette vieille administration, sans lui faire perdre les qualités, originales, qui faisaient son efficacité dans la lutte contre la fraude. La régie des Contributions indirectes était une très ancienne administration, attachée à son histoire, et marquée par ses origines. Sous l’Ancien Régime, les aides, impôts de consommation sur divers produits tels q...

  17. Quantifier pour manager. L’émergence des paiements pour services environnementaux au sein des politiques publiques environnementales françaises

    OpenAIRE

    Petitimbert, Rémy

    2016-01-01

    Le développement d’une approche managériale véhiculée notamment par les cadres cognitifs et pratiques du New Public Management a favorisé l’institutionnalisation d’indicateurs de performances et d’efficacité dans les pratiques professionnelles du secteur public. Cela a concouru à l’installation des services écosystémiques et à leur opérationnalisation à travers les Paiements pour services environnementaux. Partant de ce constat, l’article se propose d’étudier les conditions de production d’ou...

  18. Etude préliminaire de l'influence des disponibilités alimentaires et des activités humaines sur l’utilisation spatiale de l’habitat par les chimpanzés et les bonobos1

    OpenAIRE

    Narat, Victor; Cibot, Marie; Bokika Ngawolo, Jean Christophe; Dumez, Richard; Krief, Sabrina

    2012-01-01

    L’étude des interactions existant entre les populations locales, l’environnement et les grands singes est indispensable pour une meilleure compréhension des capacités d'adaptation des grands singes aux perturbations de l’habitat et pour l’évaluation des menaces spécifiques au contexte local. De telles études peuvent contribuer à améliorer l’efficacité et la durabilité des actions de conservation ainsi que le développement des populations locales. Cette étude préliminaire compare l’influence d...

  19. De la prévention des risques au changement des pratiques agricoles : les limites du droit de la protection phytosanitaire

    OpenAIRE

    Thevenot, Gaël

    2014-01-01

    Les produits phytopharmaceutiques, communément appelés pesticides, sont utilisés pour lutter contre les organismes nuisibles aux plantes et, ce faisant, assurer les rendements agricoles et les approvisionnements alimentaires. L'encadrement juridique français de ces produits s'est donc d'abord intéressé à garantir leur efficacité. Dans un second temps seulement, il a cherché à limiter les risques qu'ils présentent pour la santé et l'environnement. Depuis la stratégie thématique communautaire s...

  20. Vers des dispositifs organo-électroniques à réponses multiples

    OpenAIRE

    Raimondo, Corinna

    2012-01-01

    Les trois dernières décennies ont vu l'émergence de l'électronique organique ainsi que son établissement en tant que domaine scientifique interdisciplinaire et dans notre vie quotidienne. On dénombre actuellement deux défis scientifiques majeurs dans ce domaine. Le premier est de s'attacher à augmenter l'efficacité des dispositifs par l'utilisation de nouveaux matériaux, plutôt le deuxième consiste en l'intégration de fonctionnalités multiples un seul dispositif. Atteindre ces objectifs néces...

  1. Study of the composition of biologically active fractions from plant extracts by advanced techniques of HPLC and UHPLC/MS

    OpenAIRE

    Casetta, Cristina

    2013-01-01

    L'analyse d'extraits de plantes a augmenté d'importance soit pour la recherche des nouvelles molécules pharmaceutiques que pour le contrôle qualité des médicaments. En analytique, la récente tendance est de réduire les temps d’analyse afin d’augmenter la productivité, mais pour les analyses des plantes, les nouvelles techniques (hautes températures, particules sub-2µm ou particules superficiellement poreuses sub-3µm) sont utiles plutôt pour augmenter l’efficacité chromatographique et la sépar...

  2. NOUVELLES TECHNOLOGIES EDUCATIVES, RISQUES PEDAGOGIQUES ET CONTROLE DE GESTION

    OpenAIRE

    Bescos, Pierre-Laurent

    2000-01-01

    International audience Les Nouvelles Technologies Educatives (NTE) peuvent être très utiles pour augmenter l'efficacité pédagogique et l'implication des étudiants, notamment pour des cours en comptabilité ou contrôle de gestion. Mais leur utilisation ne se fait pas sans certains risques, à partir du moment où cela s'accompagne nécessairement de nouvelles approches pédagogiques et du fait de la dépendance vis-à-vis des diverses technologies employées. A partir d'une expérimentation sur un c...

  3. Crop weed competition and herbicide performance in cereal species and varieties

    DEFF Research Database (Denmark)

    Christensen, Svend

    1994-01-01

    des variétés sur l'efficacité herbicide. Un objectif de 5 g de matière sèche de mauvaise herbe par m2 pour toutes les variétés à la fin de la floraison a été utilisé pour déterminer un facteur de calibration varietal de la dose d'herbicide. Les résultats ont montré des différences significatives entre...

  4. Consolidation endogène de réseaux lexico-sémantiques : Inférence et annotation de relations, règles d’inférence et langage dédié

    OpenAIRE

    Zarrouk, Manel

    2015-01-01

    Développer des ressources lexico-sémantiques pour le Traitement Automatique des Langues Naturelles est un enjeu majeur du domaine. Ces ressources explicitant notamment des connaissances que seuls les humains possèdent, ont pour but de permettre aux applications de TALN une compréhension de texte assez fine et complète. De nouvelles approches populaires de construction de ces dernières impliquant l’externalisation ouverte (crowdsourcing) émergent en TALN. Elles ont confirmé leur efficacité et ...

  5. Pour l'effectivité du droit du travail : quel système d'inspection et quelle indépendance des inspecteurs ?

    OpenAIRE

    Auvergnon, Philippe

    2006-01-01

    L'effectivité du droit du droit du travail est-elle réellement possible dans un système généraliste d'inspection du travail couvrant l'ensemble des secteurs ? Ou plutôt trouve-t-elle sa place dans un système indépendant reposant sur un fondement normatif dans lequel le contrôle s'exerce loin de toute influence extérieure pouvant nuire à la réalité et l'efficacité de la mission fondamentale d'application du droit du travail ?

  6. Une approche comparative de la question de l'effectivité du droit du travail

    OpenAIRE

    Auvergnon, Philippe

    2006-01-01

    La question de l'effectivité du droit du travail n'est pas nouvelle. Toutefois, une approche comparative, à partir de différents systèmes juridiques et de relations professionnelles, permet utilement de la revisiter. Qu'entend-on par effectivité du droit ? Ne confond-on pas aujourd'hui souvent effectivité et efficacité ? Le droit du travail est-il particulièrement exposé à l'ineffectivité du fait des rapports de pouvoir prévalant dans les relations de travail subordonné ? L'analyse des effect...

  7. Le clonage somatique : un état des lieux chez les bovins et les petits ruminants

    OpenAIRE

    Heyman, Yvan; Chavatte-Palmer, Pascale; Vignon, Xavier; Richard, Christophe; Renard, Jean Paul

    2005-01-01

    Parmi les récentes biotechnologies de la reproduction chez les mammifères d’élevage, le clonage par transfert de noyaux somatiques constitue un pas en avant depuis la naissance de la brebis Dolly. Cet article fait le point sur les résultats actuels obtenus dans le monde chez les bovins et les petits ruminants, les limites de la technique et les applications potentielles. L’efficacité globale du clonage (nombre de jeunes nés /nombre d’embryons reconstitués) reste encore faible (≤ 7 %), mais el...

  8. Ressources urbaines  : un film réalisé par Créville.org.

    Directory of Open Access Journals (Sweden)

    Marc Dumont

    2008-07-01

    Full Text Available Il est certains sites internet dont on souhaiterait occulter l’existence, tenir méconnue l’ url de référence, par crainte que la publicité qu’on pourrait leur faire ne vienne, à terme, contribuer à saturer l’efficacité tenant aux contenus qu’ils proposent, ni trop abondants ni pas assez. Cédons malgré tout, pour inviter à découvrir (ou redécouvrir un portail de veille d’informations et de documentations scientifiques en matière d’espace, d’aménagement et ...

  9. Consequences of the presence of politicians or employees in the board of directors on the efficiency of firms

    OpenAIRE

    Lyon-Caen, Clément

    2015-01-01

    Cette thèse étudie l’impact de la composition du conseil d’administration sur la performance financière d’une entreprise. Elle est composée de trois chapitres. Dans le premier chapitre, nous effectuons une revue de la littérature sur les conseils d’administration. Nous pointons l’évolution de la gouvernance des entreprises au cours des dernières décennies, et montrons en quoi l’efficacité des conseils d’administration est devenue un sujet majeur de ce champ de recherche et une préoccupation i...

  10. Fusions et acquisitions et richesse des actionnaires : le cas des banques européennes

    OpenAIRE

    Diaw, Abdourahmane

    2012-01-01

    Cette thèse porte sur le lien entre fusions et acquisitions et création de valeur actionnariale. La problématique consiste à analyser ce paradoxe qui est le recours des banques aux fusions et acquisitions en dépit des résultats des recherches scientifiques qui en démontrent le peu d’efficacité en termes de rentabilité actionnariale. De prime abord nous procédons à une analyse théorique des fusions et acquisitions bancaires en insistant sur des aspects particuliers comme l’évolution du phénomè...

  11. Conception d'antennes miniatures intégrées pour solutions RF SiP

    OpenAIRE

    Jeangeorges, Mickaël

    2010-01-01

    Ce mémoire présente la conception et l'optimisation d'antennes miniatures intégrées en modules de type System in Package. L'objectif est de répondre à un besoin croissant en modules intégrés complets, comprenant tous les composants nécessaires pour apporter des fonctionnalités sans-fil aux objets communicants. Afin de remplir cet objectif, les antennes doivent satisfaire de nombreux critères, autant au niveau des performances (adaptation, bande passante, efficacité, diagramme de rayonnement) ...

  12. Effectiveness of interventions targeting frequent users of emergency departments: a systematic review

    OpenAIRE

    Althaus F.

    2012-01-01

    L'article publié de le cadre de cette thèse est intitulé "Effectiveness of interventions targeting frequent users of emergency departments: A systematic review." Il a été publié par les "Annals of Emergency Medicine (AEM)" en juillet 2011. Le titre en français pourrait être: "Efficacité des interventions ciblant les utilisateurs fréquents des services d'urgence: Une revue systématique." Le titre du journal américain pourrait être: "Annales de Médecine d'Urgence". Il s'agit du journal du "Coll...

  13. Les collectivités : une source de déchets organiques et une voie de valorisation de la chaleur pour la méthanisation agricole ?

    Directory of Open Access Journals (Sweden)

    LEVASSEUR, Pascal ; CHARPIOT, Alicia ; LE GUEN, Gaëlle

    2013-10-01

    Full Text Available Un des intérêts de la méthanisation est qu'elle peut participer à un recyclage extrêmement rentable des déchets. De fait, les collectivités ont un rôle à jouer dans ce processus car elles génèrent de nombreux types de déchets. Mais dans quelles mesures leur participation est-elle actuellement intéressante ? La volonté d'aboutir à une plus grande efficacité induit des changements de comportement de la part des foyers et des institutions. Quels sont-ils?

  14. Le système du risque à Saint-Martin (Petites Antilles françaises)

    OpenAIRE

    Virginie Duvat

    2008-01-01

    L’île de Saint-Martin constitue un terrain particulièrement intéressant pour étudier le système du risque naturel et les conditions de la co-évolution territoire/catastrophes. Les mécanismes qui s’y observent renforcent sa vulnérabilité et l’efficacité du retour d’expérience est affaiblie par des blocages d’ordre politique et juridique.The island of Saint-Martin is an interesting case study for a systemic approach applied to cyclone hazards and the co-evolution of territory and disaster manag...

  15. Une méthode pour l'appropriation de savoir-faire, capitalisé avec MASK

    OpenAIRE

    Castillo, Oswaldo; Matta, Nada; Ermine, Jean-Louis

    2004-01-01

    La gestion explicite des savoirs et savoir-faire occupe une place de plus en plus importante dans les organisations. La construction de mémoires d'entreprise dans un but de préservation et de partage est devenu une pratique assez courante. Cependant, on oublie trop suivent que l'efficacité de ces activités est étroitement liée aux capacités d'appropriation et d'apprentissage des acteurs de l'organisation. Dans cet article, nous proposons des démarches générales d'accompagnement permettant de ...

  16. De l'appropriation des connaissances vers l'acquisition des compétences

    OpenAIRE

    Castillo, Oswaldo; Matta, Nada; Ermine, Jean-Louis

    2004-01-01

    La gestion explicite des savoirs et savoir-faire occupe une place de plus en plus importante dans les organisations. La construction de mémoires d'entreprise dans un but de préservation et de partage est devenu une pratique assez courante. Cependant, on oublie trop souvent que l'efficacité de ces activités est étroitement liée aux capacités d'appropriation et d'apprentissage des acteurs de l'organisation. C'est à travers cet apprentissage que de nouvelles compétences peuvent être acquises. Da...

  17. Synthesis and investigation of new large self-assembled supramolecules as potential electron emitters

    OpenAIRE

    Alameddine, Bassam; Jenny, Titus

    2007-01-01

    La nanotechnologie, domaine de recherche qui couvre plusieurs branches scientifiques en Médecine, Biologie, Physique et Chimie, est en pleine expansion dans les institutions de recherche et suscite un vif intérêt dans l’industrie vu ses prometteuses applications. Ceci est dû à plusieurs raisons, parmi lesquelles, on note le control à une échelle moléculaire ce qui augmente l’efficacité du procédé et diminue le coût en matière première. L’auto-assemblage moléculaire, phénomène qui implique les...

  18. Dopage : prévention, répression et enjeux éthiques. Entretien avec Albane Andrieu

    OpenAIRE

    Liotard, Philippe; Andrieu, Albane

    2015-01-01

    Dans cet entretien, Albane Andrieu apporte des éclairages sur les valeurs (éthiques, sociales, juridiques…) et les enjeux qui sous-tendent une politique de prévention du dopage. Le parallèle avec la prévention des toxicomanies élargie à celle des comportements d’addiction permet d’avancer une définition et de rappeler quelques principes fondamentaux d’une démarche de prévention. De même, elle interroge la cohérence et l’efficacité des politiques actuelles qui envisagent le dopage à travers un...

  19. Les insectes des stocks de maïs villageois en Côte d'Ivoire et leur contrôle

    OpenAIRE

    Moyal, Pascal

    1990-01-01

    Un bilan des résultats des études entomologiques effectuées depuis dix ans sur le maïs stocké chez les paysans de Côte d'Ivoire est présenté : les sujets abordés concernent les ravageurs rencontrés et leur importance, les dégâts suivant les régions et l'efficacité de traitements insecticides dans les diverses conditions de stockage. (Résumé d'auteur)

  20. Réguler pour contrôler le développement de la résistance aux pesticides (La durabilité de la sensibilité des bioagresseurs aux pesticides et aux variétés résistantes)

    OpenAIRE

    Stefan Ambec; Marion Desquilbet

    2011-01-01

    L’utilisation de pesticides et l’introduction de variétés résistantes à certains bioagresseurs (insectes, champignons, virus, bactéries) en agriculture exercent une pression de sélection sur ces populations de bioagresseurs. Au cours du temps, l’efficacité de ces technologies peut diminuer si des résistances (aux pesticides ou aux variétés résistantes) se développent. La durabilité des pesticides et des variétés résistantes est donc en grande partie tributaire de leur utilisation. Plus une te...

  1. RITUXIMAB DANS LA POLYARTHRITE RHUMATOÏDE

    OpenAIRE

    ABABOU, Hadjer; DAFFI, SOUMIA

    2012-01-01

    La polyarthrite rhumatoïde est un rhumatisme inflammatoire chronique. Les biothérapies mises au point ont révolutionné la prise en charge du patient, parmi ceux-ci, on peut citer le Rituximab: est un anticorps monoclonal inhibant spécifiquement le récepteur CD20 des lymphocytes B. Notre travail a pour buts d'évaluer l'efficacité de Rituximab dans le traitement de polyarthrite rhumatoïde chez les patients suivis dans le service de rééducation CHU Tlemcen. Il s'agit d'une étud...

  2. Comportement alimentaire, quantités ingérées et performances des bovins conduits en groupe

    OpenAIRE

    Ingrand, Stéphane

    2000-01-01

    La hiérarchie sociale et les effets d’entraînement sont deux composantes importantes du comportement social qui influencent fortement le niveau d’ingestion et le comportement alimentaire des bovins conduits en groupe. Cet effet se traduit pour des animaux à besoins nutritionnels élevés (animaux laitiers ou en croissance) par des niveaux d’ingestion supérieurs et une moindre efficacité alimentaire par rapport à des situations où les animaux sont alimentés individuellement (à l’attache ou en bo...

  3. Des rites pour vivre en fin de vie: enjeux pour le soin et les soins palliatifs

    OpenAIRE

    Jacquemin, Dominique

    2011-01-01

    C'est la présence du professionnel -sans oublier ici les accompagnants bénévoles- qui permettra au malade de vivre le soin comme rite, c’est-à-dire passage où des dimensions de l’existence habituellement non dites et vécues en opposition -vie/mort, efficacité/lâché prise, objectivation/subjectivation, bonheur/malheur- puissent se vivre et donner au soin sa dimension ultime, restant dans sa pleine dimension médicale.

  4. Intégration de la Ventilation Naturelle en Façade de Bâtiment

    OpenAIRE

    Migneron, Jean-Philippe

    2010-01-01

    Les nouvelles tendances dans le monde de la construction se tournent vers le bâtiment écoénergétique. En Amérique du Nord, les nouvelles normes en matière de développement durable deviennent choses communes. Parmi les multiples possibilités d'augmentation de l'efficacité des édifices, il est maintenant reconnu que l'utilisation de la ventilation naturelle permet de diminuer la consommation et d'accroître la satisfaction des occupants. L'intégration de la fenestration et des ouvertures d'aérat...

  5. Impact contrôle automatisé feu rouge : Eléments de réflexion critiques autour d'une revue de littérature

    OpenAIRE

    CARNIS, L

    2010-01-01

    Ce document constitue une revue critique de la littérature internationale sur le contrôle automatisé feu rouge. Il s'organise en trois parties. La première souligne la diversité existante en matière de contrôle automatisé des feux rouges. Une politique largement utilisée au niveau international, mais qui se distingue par la mise en oeuvre de structures institutionnelles spécifiques et par la recherche d'objectifs divers. La deuxième partie s'interroge sur l'efficacité de tels dispositifs de c...

  6. Plasma riche en plaquettes et lésions tendineuses

    OpenAIRE

    Kaux, Jean-François; Drion, Pierre; Croisier, Jean-Louis; Colige, Alain; Libertiaux, Vincent; Gothot, André; Crielaard, Jean-Michel

    2014-01-01

    Les plaquettes contiennent divers facteurs de croissance, libérés lors de la dégranulation qui fait suite à leur activation. Ces facteurs favorisent le remodelage tissulaire, la cicatrisation et l’angiogenèse. Actuellement, l’effet clinique du Plasma Riche en Plaquettes (PRP) reste toujours discuté voire controversé. Nos recherches ont évalué l’efficacité du PRP sur la cicatrisation tendineuse de l’animal et de l’homme souffrant de jumper’s knee chronique.

  7. Musique et pouvoirs

    OpenAIRE

    Aubert, Laurent; Bois, Pierre; Borel, François; Brandily, Monique; CAUFRIEZ, Anne; Cheyronnaud, Jacques; Crowe, Peter; Desjacques, Alain; During, Jean; Erguner, Ahmed Kudsi; Helffer, Mireille; Howard, Keith; Leymarie, Isabelle; Lortat-Jacob, Bernard; Mesnil, Marianne

    2015-01-01

    Selon une croyance quasi universelle, certaines musiques sont investies de pouvoirs, d'où leur efficacité dans des rites permettant à l'individu ou à la collectivité de communiquer avec le monde invisible. D'autres musiques sont porteuses de messages subliminaux et d'effets, dans la mesure où leurs formes sont adaptées à leur finalité. Ainsi, l'usage de la musique à des fins politiques est fréquent, en tant que signe du pouvoir ou que de véhicule de sa propagation. Cette relation peut d'aille...

  8. Structures de données et méthodes formelles

    CERN Document Server

    Guyomard, Marc

    2011-01-01

    Ce livre porte sur l tude des structures de donn es, savoir des constituants logiciels dont la qualit conditionne le bon fonctionnement et l efficacit des applications informatiques. L originalit de cet ouvrage r side essentiellement dans le lien qu il tablit avec la discipline des m thodes formelles pour le g nie logiciel. Il montre comment il est possible de calculer les op rations qui accompagnent une structure de donn es partir d une sp cification rigoureuse. L auteur adopte la fois une perspective historique et une d marche fonctionnelle. La premi re partie de l ouvrage pr sente les bases

  9. Getting simultaneous red and near infrared bands from a single digital camera for plant monitoring applications

    OpenAIRE

    Rabatel, G.; Gorretta, N.; Labbé, S.

    2012-01-01

    Les images multispectrales incluant une bande rouge et une bande infrarouge ont prouvé leur efficacité pour la discrimination entre sol et végétation et le suivi cultural en télédétection. Mais elles restent rarement utilisées pour l'imagerie au sol ou par drone, du fait de la non disponibilité de capteurs adaptés. Nous proposons ici une solution originale pour obtenir simultanément les bandes rouge et infrarouge à partir d'un appareil photographique couleur ordinaire, après avoir retiré le f...

  10. Encore un effort pour rendre la gouvernance démocratique !

    OpenAIRE

    Pinson, Gilles

    2008-01-01

    Même s'il est souvent critiqué, le terme de «gouvernance» permet de rendre compte de réalités nouvelles : à l'échelle internationale ou locale, l'action publique s'est complexifiée. On ne commande plus si facilement aux hommes et aux choses. Mais la gouvernance sans gouvernement pose autant de problèmes qu'elle n'en résout puisque c'est son fonctionnement opaque, consensuel, à l'abri des regards, qui semble le garant de son efficacité.

  11. LASER THULIUM EFFICACE BASE SUR UNE FIBRE A GRANDE AIRE MODALE A TRIPLE GAINE FABRIQUEE PAR LA METHODE REPUSIL

    OpenAIRE

    Darwich, Dia; Dauliat, Romain; Jamier, Raphaël; Benoit, Aurélien; Grimm, Stephan; Schuster, Kay; Roy, Phillipe

    2015-01-01

    Nous rapportons ici une fibre à large aire modale de 18 µm de diamètre de coeur dopée thulium fabriquée par un procédé alternatif nommé Repusil et présentant un profil à triple gaine. Cette fibre, caractérisée en configuration laser, nous a permis d'obtenir un faisceau monomode transverse proche de la limite de diffraction (M x,y 2 < 1,1) avec une efficacité laser de 50,4%.

  12. Une vision trivaluée pour les problèmes SAT et MAX-SAT

    OpenAIRE

    Lardeux, Frédéric; Saubion, Frédéric; Hao, Jin-Kao

    2005-01-01

    Dans cet article nous proposons un nouveau cadre de résolution pour les problèmes SAT et AX-SAT. Ce cadre introduit la troisième valeur de vérité ``indéterminé'' dans le but d'améliorer l'efficacité de la résolution. Nous avons adapté l'algorithme de recherche Tabou ainsi que Walksat avec ce nouveau cadre de résolution. Des résultats prometteurs ont été obtenus et montrent l'intérêt de notre approche.

  13. Techniques de combustion Combustin Techniques

    OpenAIRE

    Perthuis E.

    2006-01-01

    L'efficacité d'un processus de chauffage par flamme est étroitement liée à la maîtrise des techniques de combustion. Le brûleur, organe essentiel de l'équipement de chauffe, doit d'une part assurer une combustion complète pour utiliser au mieux l'énergie potentielle du combustible et, d'autre part, provoquer dans le foyer les conditions aérodynamiques les plus propices oux transferts de chaleur. En s'appuyant sur les études expérimentales effectuées à la Fondation de Recherches Internationale...

  14. Amélioration des performances des moteurs à combustion par amélioration du système d'allumage

    OpenAIRE

    Astanei, Dragoş-George

    2014-01-01

    Face aux normes actuelles et futures, de plus en plus drastiques, concernant les émissions de polluants, les constructeurs automobiles cherchent en permanence à améliorer l'efficacité des moteurs à allumage commandé. Une des solutions les plus efficaces et applicables pour diminuer la quantité de polluants émis dans les gaz d’échappement (HC, CO, NOx) et réduire la consommation de carburant, est d’utiliser un mélange très pauvre (richesse du mélange inférieure à 0,6). Toutefois, ce concept de...

  15. Les systèmes de télécommunications existants ou émergents dans le domaine des transports guidés

    OpenAIRE

    Berbineau, M.

    2001-01-01

    Les opérateurs de transports guidés s'appuient de plus en plus sur les nouvelles technologies de l'information et de la communication qui leur permettent d'améliorer l'efficacité, les performances et la sécurité des déplacements, de réduire les coûts de fonctionnement et de maintenance, mais aussi de moderniser leur image et de rendre les transports publics plus attractifs. Cependant, il existe un certain nombre de difficultés liées à l'introduction de ces technologies innovantes dans le doma...

  16. Environmental activity of bacteria degrading pollutants

    OpenAIRE

    Moreno Forero S. C.

    2015-01-01

    Une des meilleures techniques pour décontaminer l'environnement d'éléments toxiques (comme par exemple le dibenzofuan, DBF et le 4-chlorophenol, 4CP) déposés par l'homme, à bas coûts et sans le perturber considérablement, est sans doute la biorémédiation, et particulièrement la bioaugmentation. Malheureusement, si plusieurs microorganismes ont démontré leur efficacité à dégrader les composés toxiques en conditions de laboratoire, plusieurs tentatives afin de les utiliser dans l'environnement ...

  17. Application des techniques multiporteuses de type OFDM pour les futurs systèmes de télécommunications par satellite

    OpenAIRE

    Ho, Anh Tai

    2009-01-01

    Cette thèse étudie la possibilité d'appliquer les techniques de modulations multiporteuses de type OFDM dans les futurs systèmes de communications par satellite. Elle traite notamment du problème de synchronisation au niveau récepteur pour les systèmes de diffusion par satellite en bande Ka. L'objectif est de proposer une structure de réception ayant besoin du moins de ressources possibles pour synchroniser afin d'optimiser l'efficacité spectrale du système et obtenir un gain par rapport à un...

  18. Conservation Priorities when Species Interact: The Noah's Ark Metaphor Revisited

    OpenAIRE

    Courtois, Pierre; Figuieres, Charles; Mulier, Chloé

    2014-01-01

    Cette note intègre les interactions écologiques dans le problème Arche de Noé [ML Weitzman, The Noah's Arch problem, Econometrica 66 (6) (1998) 1279-1298]. Ce faisant, nous arrivons à un modèle général pour étudier le classement des projets de conservation in situ pour des espèces en interactions, et nous offrons une méthode coût-efficacité opérationnelle afin de mieux préserver la diversité sous une contrainte de budget.

  19. Analyser l'innovation dans un Système agroalimentaire localisé : construction interdisciplinaire en Languedoc

    OpenAIRE

    Touzard, Jean-Marc; Chiffoleau, Yuna; Dreyfus, Fabrice

    2008-01-01

    L'article analyse les processus d'innovation dans les coopératives viticoles du Languedoc en associant trois approches de l'innovation croisant économie et sociologie. L'analyse économique et statistique montre la diversité de combinaisons d'innovations élémentaires et leur efficacité lorsqu'elles couvrent différentes étapes de la production. L'analyse longitudinale de systèmes d'action innovants souligne l'importance des connaissances et relations construites dans des processus soumis à de n...

  20. Evolutions et enjeux de la coopération internationale au développement

    Directory of Open Access Journals (Sweden)

    Gérard Perroulaz

    2010-03-01

    Full Text Available Le volume de l’aide publique au développement (APD fournie par les pays de l’OCDE atteint de nouveaux records. Les flux enregistrés au titre de l’APD incluent toutefois des catégories de dépenses qui ne concourent pas à l’objectif de réduction de la pauvreté dans les pays en développement. Les économies émergentes et les donateurs privés procurent une part croissante de l’aide. Des progrès ont été réalisés dans la mise en œuvre de la Déclaration de Paris sur l’efficacité de l’aide dans quelques domaines comme le déliement de l’aide, mais les résultats ne sont pas à la hauteur des attentes. L’approche demeure trop souvent techniciste et élude les dynamiques politiques qui ont une incidence majeure sur l’efficacité de l’aide. La question de la cohérence des politiques publiques au service du développement revient sur le devant de la scène, alors que les débats sur le changement climatique appellent à reconsidérer certains objectifs et stratégies des agences de coopération.

  1. Bilateral dyb venos trombose og vena cava-aplasi behandlet med lokal trombolyse

    DEFF Research Database (Denmark)

    Pelta, A.M.; Jorgensen, M.; Jensen, L.P.; Just, Sven Richardt Lundgren

    2008-01-01

    In this case report the treatment of a young man with bilateral iliaco-femoral DVT and vena cava aplasia is presented. The patient was treated with catheter-directed thrombolysis; the catheters were introduced in the thrombus of both legs via v. popliteae. The treatment led to almost complete thr...... thrombus resolution and no valvular incompetence at three months follow-up. In our opinion this treatment should be offered even in complex cases of acute proximal deep venous thrombosis Udgivelsesdato: 2008/5/19...

  2. Disease: H00847 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00847 Al-Awadi/Raas-Rothschild syndrome; Ulna and fibula, absence of, with sever l...imb deficiency Al-Awadi/Raas-Rothschild syndrome is a limb malformation disorder that has overlapping phenot...7A function in Al-Awadi/Raas-Rothschild syndrome whereas impairment is partial in...(description) Camera G, Ferraiolo G, Leo D, Spaziale A, Pozzolo S Limb/pelvis-hypoplasia/aplasia syndrome (Al-Awadi/Raas-Rothschild...range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia sy

  3. Study of erythropoiesis with 59Fe and erythrocyte survival with 51Cr in aplastic anemia

    International Nuclear Information System (INIS)

    A study of erythropoiesis with 59Fe and erythrocyte survival with 51Cr was carried out in 25 patients with aplastic anemia and in a control group of 23 healthy persons. Bone marrow aplasia was uniform in all patients but differences in erythropoiesis were established. According to the state of erythropoiesis, the patients were divided into two groups: 1) patients with severe damage of erythropoiesis and 2) patients with preserved erythropoiesis. Erythrocyte survival in both groups was shortened. The data obtained correlate with the anemic syndrome and help to explain its pathogenesis. It is suggested that the investigation of erythropoiesis with 59Fe and 51Cr is of prognostic value. (author)

  4. The role of human ribosomal proteins in the maturation of rRNA and ribosome production

    OpenAIRE

    Robledo, Sara; Rachel A Idol; Crimmins, Dan L.; Ladenson, Jack H.; Mason, Philip J.; Bessler, Monica

    2008-01-01

    Production of ribosomes is a fundamental process that occurs in all dividing cells. It is a complex process consisting of the coordinated synthesis and assembly of four ribosomal RNAs (rRNA) with about 80 ribosomal proteins (r-proteins) involving more than 150 nonribosomal proteins and other factors. Diamond Blackfan anemia (DBA) is an inherited red cell aplasia caused by mutations in one of several r-proteins. How defects in r-proteins, essential for proliferation in all cells, lead to a hum...

  5. Multifocal Aeromonas Osteomyelitis in a Child with Leukemia.

    Science.gov (United States)

    Doganis, Dimitrios; Baka, Margarita; Tsolia, Maria; Pourtsidis, Apostolos; Lebessi, Evangelia; Varvoutsi, Maria; Bouhoutsou, Despina; Kosmidis, Helen

    2016-01-01

    Aeromonas hydrophila is a Gram negative organism causing both intestinal and extraintestinal disease. The case of a 14-year-old girl with underlying immunodeficiency and leukemia who developed systemic A. hydrophila infection is described in this report. While in deep bone marrow aplasia she developed fever, severe pain in the lower extremities, and swelling of the left femur. Blood culture showed Escherichia coli and A. hydrophila whereas pus culture from the soft tissue swelling showed the presence of A. hydrophila. Imaging studies showed diffuse osteolytic lesions. Patient received 5 months of intravenous and oral antibiotics and she improved clinically whereas the radiology findings persisted. PMID:27200197

  6. Sarcoidosis presenting with severe hypocalcaemia.

    LENUS (Irish Health Repository)

    Saeed, A

    2012-01-31

    Disorders of calcium metabolism, especially hypercalcemia and hypercalceuria, are common in sarcoidosis. They are caused by extra renal unsuppressed production of 1,25 dihydroxy vitamin D at the level of the sarcoid granuloma. Hormonal changes during pregnancy have a physiological synergistic effect on this mechanism, which is primarily parathyroid hormone (PTH) dependant. However, the combination of primary hypoparathyroidism with hypocalcemia and sarcoidosis is rare. Di George syndrome, is a dysmorphic disorder characterised by aplasia\\/hypoplasia of thymus and parathyroid glands in addition to aortic arch anamolies and facial dysmorphia. After commencing appropriate treatment this lady made excellent recovary.

  7. Multifocal Aeromonas Osteomyelitis in a Child with Leukemia

    Directory of Open Access Journals (Sweden)

    Dimitrios Doganis

    2016-01-01

    Full Text Available Aeromonas hydrophila is a Gram negative organism causing both intestinal and extraintestinal disease. The case of a 14-year-old girl with underlying immunodeficiency and leukemia who developed systemic A. hydrophila infection is described in this report. While in deep bone marrow aplasia she developed fever, severe pain in the lower extremities, and swelling of the left femur. Blood culture showed Escherichia coli and A. hydrophila whereas pus culture from the soft tissue swelling showed the presence of A. hydrophila. Imaging studies showed diffuse osteolytic lesions. Patient received 5 months of intravenous and oral antibiotics and she improved clinically whereas the radiology findings persisted.

  8. Ultrasonography of various thyroid diseases in children and adolescents: A pictorial essay

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hyun Sook; Lee, Eun Hye; Jeong, Sun Hye; Park, Ji Sang; Lee, Heon [Dept. of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon (Korea, Republic of)

    2015-04-15

    Thyroid imaging is indicated to evaluate congenital hypothyroidism during newborn screening or in cases of a palpable thyroid mass in children and adolescents. This pictorial essay reviews the ultrasonography (US) of thyroid diseases in children and adolescents, including normal thyroid gland development, imaging features of congenital thyroid disorders (dysgenesis, [aplasia, ectopy, hypoplasia], dyshormonogenesis, transient hypothyroidism, thyroglossal duct cyst), diffuse thyroid disease (Grave's disease, Hashimoto's thyroiditis, and suppurative thyroiditis), and thyroid nodules. The primary imaging modalities for evaluating thyroid diseases are US and radionuclide scintigraphy. Additionally, US can be used to guide aspiration of detected nodules.

  9. Hematopoietic Stem Cell Transplantation and History

    Directory of Open Access Journals (Sweden)

    Atila Tanyeli

    2014-02-01

    Full Text Available Attemps to employ marrow stem cell for therapeutic purpose began in 1940’s. Marrow transplantation might be of use not only in irradiation protection, but also with therapeutic aim to marrow aplasia, leukemia and other diseases. The use and defining tissue antigens in humans were crucial to the improving of transplantation. The administration of methotrexate for GVHD improved the long term survival. Conditioning regimens for myeloablation designed according to diseases. Cord blood and peripheral blood stem cells were used for transplantion after 1980’s. Cord blood and bone marrow stem cell banks established to find HLA matched donor.

  10. Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma

    Institute of Scientific and Technical Information of China (English)

    Bernhard Glodny; Alexandar Tzankov; Germar-Michael Pinggera; Johannes Petersen; Ralf Herwig

    2006-01-01

    A 32-year-old man recovered completely from hypokalemic hypertension that had been caused by primary reninism after the ablation of an ectopic left testis, epididymis and ductus deferens. For several years, severe hypertension has been resistant to treatment, even the concurrent administration of up to seven antihypertensive agents. In this case,cryptorchidism was associated with an indirect inguinal hernia and an open peritoneo-vaginal process on both sides,aplasia of the posterior wall of the inguinal canal on the right side, an umbilical hernia, and a retroperitoneal tendrillar hemangioma.

  11. Complete recovery after the removal of an ectopic testicle in a case of primary reninism and retroperitoneal hemangioma.

    Science.gov (United States)

    Glodny, Bernhard; Tzankov, Alexandar; Pinggera, Germar-Michael; Petersen, Johannes; Herwig, Ralf

    2006-03-01

    A 32-year-old man recovered completely from hypokalemic hypertension that had been caused by primary reninism after the ablation of an ectopic left testis, epididymis and ductus deferens. For several years, severe hypertension has been resistant to treatment, even the concurrent administration of up to seven antihypertensive agents. In this case, cryptorchidism was associated with an indirect inguinal hernia and an open peritoneo-vaginal process on both sides, aplasia of the posterior wall of the inguinal canal on the right side, an umbilical hernia, and a retroperitoneal tendrillar hemangioma. PMID:16491279

  12. Ultrasonography of various thyroid diseases in children and adolescents: A pictorial essay

    International Nuclear Information System (INIS)

    Thyroid imaging is indicated to evaluate congenital hypothyroidism during newborn screening or in cases of a palpable thyroid mass in children and adolescents. This pictorial essay reviews the ultrasonography (US) of thyroid diseases in children and adolescents, including normal thyroid gland development, imaging features of congenital thyroid disorders (dysgenesis, [aplasia, ectopy, hypoplasia], dyshormonogenesis, transient hypothyroidism, thyroglossal duct cyst), diffuse thyroid disease (Grave's disease, Hashimoto's thyroiditis, and suppurative thyroiditis), and thyroid nodules. The primary imaging modalities for evaluating thyroid diseases are US and radionuclide scintigraphy. Additionally, US can be used to guide aspiration of detected nodules.

  13. Aplastic anaemia preceding acute lymphoblastic leukaemia in an adult with isolated deletion of chromosome 9q.

    LENUS (Irish Health Repository)

    Kelly, Kevin

    2008-12-01

    Aplastic anaemia (AA) can precede acute lymphoblastic leukaemia (ALL) in 2% of children but this is rarely reported to occur in adults. A 21-year-old male presented with bone marrow failure and bone marrow biopsy showed a profoundly hypocellular marrow. He recovered spontaneously but represented 2 months later when he was diagnosed with pre-B acute lymphoblastic leukaemia. Chromosomal examination revealed 46,XY,del(9)(q13q34). To the best of our knowledge this is the first case to be reported of aplasia preceding ALL with 9q minus as the sole chromosomal abnormality.

  14. Terrorist threat, chemical, biological, radiological, nuclear medical approach

    International Nuclear Information System (INIS)

    The different aspects linked to the use of nuclear, radiological, biological and or chemical weapons are gathered in this work. They concern history, fundamental aspect, diagnosis, therapy and prevention. The part devoted to the nuclear aspect concern the accidents in relation with ionizing radiations, the radiation syndrome, the contribution and limits of dosimetry, the treatment of medullary aplasia, the evaluation and treatment of an internal contamination, new perspectives on the use of cytokine for the treatment of accidental irradiated persons, alternative to the blood transfusion. (N.C.)

  15. Derrame pleural en enfermedad de Milroy

    OpenAIRE

    Juan José Celis-Jiménez; María Daniela Barrios-Morales; Lorena Verónica Martínez-Zamora; Sara Inés Briceño Berbesí; José David Betancourt Salinas; Francisco R. Cammarata Scalisi

    2013-01-01

    La enfermedad de Milroy, también conocida como linfedema congénito primario, fue descrita inicialmente en 1892 por William Forsyth Milroy. Es una afección que se presenta generalmente en el nacimiento, o bien durante la infancia, de origen genético con patrón de herencia autosómico dominante, causada por un defecto en el receptor 3 del factor de crecimiento endotelial vascular VEGFR3, lo que conlleva a hipoplasia o aplasia de vasos linfáticos, mayormente de miembros inferiores hecho que se ma...

  16. Screening for neonatal hypothyroidism using filter paper spot TSH (RIA) in Beijing

    International Nuclear Information System (INIS)

    From May 1985 to December 1987, a survey of 15500 newborns for neonatal hypothyroidism using filter paper spot RIA for TSH and T4 was carried out in Beijing. Those infants with TSH values higher than 25 mU/L and/or T4 values lower than 3 μg/dl were recalled for further examination. The recall rate was 0.56%. Two infants were confirmed to have congenital hypothyroidism by serum TSH, T4(RIA) and thyroid scintigraphy wity 99mTc pertechnetate. One showed thyroid aplasia and the other ectopic thyroid. The incidence of hypothyroidism was 1:7750

  17. MURCS association--a review of 7 cases.

    Directory of Open Access Journals (Sweden)

    Mahajan P

    1992-07-01

    Full Text Available MURCS association (Mullerian hypoplasia/aplasia, renal agenesis and cervicothoracic somite dysplasia is emerging as the second most frequent cause of primary amenorrhoea after Turner syndrome. Seven cases have been described and analysed. All cases had absence of uterus and tubes 85% had cervical spine abnormalities such as vertebral fusion, hypoplasia of vertebrae or butterfly vertebrae and short stature and 28% had renal agenesis or ectopy. The latter finding is in contrast to the reports in world literature where the frequency of renal agenesis is higher. There was no familial incidence in these seven cases lending credence to the belief that the association is essentially sporadic.

  18. Disease: H00676 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available der; Eye disease FOXE3 [HSA:2301] [KO:K09398] ICD-10: Q12.3 MeSH: C537786 OMIM: 610256 PMID:19708017 (description) Iseri SU, Osborn...lgros MP, Schwartz C, Delbosc B, Delpech M, Kantelip B Homozygous nonsense mutation in the FOXE3 gene as a c...H00676 Congenital primary aphakia Congenital primary aphakia (CPA) is a rare congenital eye disor...der characterized by the absence of lens. Formation of lens and lens-induced anterior structur...es does not take place in CPA, resulting in complete aplasia of the anterior segment of the eye. CPA is caus

  19. Evaluation of cleft lip and palate by computed tomography with 2 mm thin slice scanning, 2

    International Nuclear Information System (INIS)

    Computed tomography was performed on 104 patients with cleft lip and palate by continuous 2 mm slice scanning. The type of hard palate was classified as normal, hypoplasia and aplasia, depending on its developmental degree. The shape of alveolus was also classified as circular, triangular and asymmetric forms for the evaluation of the maxillary development. The hard palate development correlated with the shape of the alveolus, the diameter of maxillary and mandibular bone, and frequency of sinusitis and otitis media. Evaluation of the hard palate by thin slice scanning is useful in presumption of future fecial development. (author)

  20. How many breaks do we need to CATCH on 22q11?

    Energy Technology Data Exchange (ETDEWEB)

    Dallapiccola, B.; Pizzuti, A.; Novelli, G. [Univ. of Rome, Rome (Italy)]|[Univ. of Milan (Italy)]|[CSS IRCCS Hospital, San Giovanni Rotondo (Italy)

    1996-07-01

    The major clinical manifestations of DiGeorge syndrome (DGS; MIM 188400), which reflect developmental abnormalities of the 3d and 4th pharyngeal pouch derivatives, include thymus- and parathyroid-gland aplasia or hypoplasia and conotruncal cardiac malformations. The additional dysmorphic facial features, such as hypertelorism, cleft lip and palate, bifid uvula, and small/low-set ears, which are also common, presumably reflect the same defect. The DGS phenotype has been associated with chromosome abnormalities and, sometimes, is the effect of teratogenic agents such as retinoic acid and alcohol. 53 refs., 1 fig.

  1. Evaluation of cleft lip and palate by computed tomography with 2 mm thin slice scanning, 2

    Energy Technology Data Exchange (ETDEWEB)

    Uchiyama, Mayuki; Tanaka, Hiroshi; Harada, Junta (Jikei Univ., Tokyo (Japan). School of Medicine)

    1992-06-01

    Computed tomography was performed on 104 patients with cleft lip and palate by continuous 2 mm slice scanning. The type of hard palate was classified as normal, hypoplasia and aplasia, depending on its developmental degree. The shape of alveolus was also classified as circular, triangular and asymmetric forms for the evaluation of the maxillary development. The hard palate development correlated with the shape of the alveolus, the diameter of maxillary and mandibular bone, and frequency of sinusitis and otitis media. Evaluation of the hard palate by thin slice scanning is useful in presumption of future fecial development. (author).

  2. Evaluation of cleft lip and palate by computed tomography with 2 mm thin slice scanning

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Hiroshi

    1988-07-01

    Computed tomography was carried out in 65 patients of cleft lip and palate with continuous 2 mm slice scanning. The cleft lip and palate was classified by shape of the hard palate as normal, hypoplasia, and aplasia, depending on its developmental degree. The shape of alveolus was also grouped as circular, triangular, and asymmetric forms for the evaluation of maxillar development. The hard palatal development well correlated with the shape of the alveolus. Frequency of sinusitis and mastoiditis increased with the severity of hard palatal malformation. Evaluation of the hard palate by thin slice scanning is usefull standpoint of presumption of future maxillary development.

  3. Evaluation of cleft lip and palate by computed tomography with 2 mm thin slice scanning

    International Nuclear Information System (INIS)

    Computed tomography was carried out in 65 patients of cleft lip and palate with continuous 2 mm slice scanning. The cleft lip and palate was classified by shape of the hard palate as normal, hypoplasia, and aplasia, depending on its developmental degree. The shape of alveolus was also grouped as circular, triangular, and asymmetric forms for the evaluation of maxillar development. The hard palatal development well correlated with the shape of the alveolus. Frequency of sinusitis and mastoiditis increased with the severity of hard palatal malformation. Evaluation of the hard palate by thin slice scanning is usefull standpoint of presumption of future maxillary development. (author)

  4. Você conhece esta síndrome? Do you know this syndrome?

    OpenAIRE

    Nadia Aparecida Pereira de Almeida; Flavia Serafini; Janaine Marchiori; Julie Gomes Del Moro

    2010-01-01

    A síndrome de Bart é caracterizada pela tríade de manifestações clínicas: epidermólise bolhosa, aplasia de cútis e anormalidades ungueais. Presume-se que a ausência congênita de pele segue as linhas de Blaschko. O tratamento visa a evitar infecções secundárias. O prognóstico é bom e depende da cicatrização das bolhas.Bart's syndrome is characterized by three clinical manifestations: epidermolysis bullosa, congenital absence of skin, and nail abnormalities. It is believed that congenital skin ...

  5. Mutations in different components of FGF signaling in LADD syndrome.

    Science.gov (United States)

    Rohmann, Edyta; Brunner, Han G; Kayserili, Hülya; Uyguner, Oya; Nürnberg, Gudrun; Lew, Erin D; Dobbie, Angus; Eswarakumar, Veraragavan P; Uzumcu, Abdullah; Ulubil-Emeroglu, Melike; Leroy, Jules G; Li, Yun; Becker, Christian; Lehnerdt, Kai; Cremers, Cor W R J; Yüksel-Apak, Memnune; Nürnberg, Peter; Kubisch, Christian; Kubisch, Chriütian; Schlessinger, Joseph; van Bokhoven, Hans; Wollnik, Bernd

    2006-04-01

    Lacrimo-auriculo-dento-digital (LADD) syndrome is characterized by lacrimal duct aplasia, malformed ears and deafness, small teeth and digital anomalies. We identified heterozygous mutations in the tyrosine kinase domains of the genes encoding fibroblast growth factor receptors 2 and 3 (FGFR2, FGFR3) in LADD families, and in one further LADD family, we detected a mutation in the gene encoding fibroblast growth factor 10 (FGF10), a known FGFR ligand. These findings increase the spectrum of anomalies associated with abnormal FGF signaling. PMID:16501574

  6. The application of total or selective decontamination in dog bone marrow transplantation

    International Nuclear Information System (INIS)

    Total body irradiation (TBI) is used to prepare patients for the transfusion of allogeneic bone marrow (BM) cells. It includes a period of severe BM aplasia that lasts until donor BM cells have sufficiently regenerated. Conventionally treated, totally decontaminated and selectively decontaminated dogs were treated with 7.5 Gy TBI and 2 X 108 BM cells.kg-1 body weight plus additional donor lymph node cells from a DLA identical sibling. The aim of these studies was to solve the practical problems of total and selective decontamination in dogs and to determine the effects of these procedures on endogenous infections after TBI and the severity of GvHD. (Auth.)

  7. Experimental examinations of the late effect of ionizing radiation in fowl

    International Nuclear Information System (INIS)

    Late effects of X-irradiation on the reproductive system of chickens and on the leukosis rate were determined. No cases of leukosis were observed in White Rock and Leghorn chickens, which were irradiated with 500 R at the age of 1, 6 and 12 days. Aplasia of reproductive organs was recorded in 84% of the animals, whereas in 12% hypoplasia of oviduct and ovary took place. In Leghorn chickens which were irradiated with 400 R at the age of 1 and 6 days and parallely treated with methyl methanosulphonate, leukosis was established in 8% of all treated animals, i.e. in 22% of chickens that survived the acute toxic effect

  8. Infecção por Chryseobacterium indologenes: relato de um caso Chryseobacterium indologenes infection: a case report

    OpenAIRE

    Renata de Souza Ferreira; Fabiana Ferreira Barbosa Brandão; Suzana Margareth Lobo

    2010-01-01

    Relatamos um caso de infecção por Chryseobacterium indologenes, presente na cultura de aspirado traqueal em paciente sob ventilação mecânica invasiva, revisando os aspectos epidemiológicos, microbiológicos e o tratamento na unidade de terapia intensiva. Paciente do sexo masculino, 30 anos, internado com quadro de aplasia de medula idiopática e neutropenia febril foi transferido para a unidade de terapia intensiva com quadro de broncopneumonia e sepse grave de origem pulmonar. A maioria dos ca...

  9. Disostosis cleidocraneal: Revisión bibliográfica a propósito de un caso clínico.

    OpenAIRE

    Bernardita Toro; Antonieta Pérez; Claudia Fierro

    2012-01-01

    RESUMEN La Disostosis Cleidocraneal (CCD) es un raro trastorno congénito del esqueleto, asociado a hipoplasia o aplasia clavicular, retardo en el cierre de las fontanelas craneales, con tipo braquicéfalos, retraso de la exfoliación de la dentición temporal, erupción retardada de dientes permanentes, presencia de varios supernumerarios y alteraciones morfológicas del maxilar y mandíbula. El trastorno se hereda como una condición autosómica dominante y en el 40% de los casos de la CCD aparece ...

  10. Unilateral absence of cerebellar hemisphere: a case report

    International Nuclear Information System (INIS)

    We describe a 38-year-old woman with absence of right cerebellar hemisphere incidentally discovered by MR imaging. No cerebellar abnormality was detected on neurological examination. Tissue probably representing dysgenetic cerebellar tissue with no corticomedullary differentiation was present, connected to the right superior cerebellar peduncle. Ipsilateral enlargement of the pons and cerebral peduncle were additional findings. Although the terms ''aplasia'' or ''agenesis'' have been used to describe this entity, intrauterine destruction is the presumed pathogenetic mechanism in our case, and therefore these terms have been avoided. Asymmetry of pons and mesencephalon may be related to compensatory reorganisation or to the impairment of sequential development of nuclei and neural tracts. (orig.)

  11. Mayer-Rokitansky-Kuster-Hauser syndrome: a review

    Science.gov (United States)

    Londra, Laura; Chuong, Farah S; Kolp, Lisa

    2015-01-01

    The congenital aplasia or severe hypoplasia of mullerian structures is infrequent. However, the features of normal female endocrine function paired with the absence of a functional uterus and vagina makes it a fascinating entity. The diagnosis and work-up in these patients has become very efficient, thanks to the use of imaging, and there are multiple successful procedures for the creation of a neovagina. In recent years, infertility treatment options through in vitro fertilization have also become available as part of the long-term care of these patients. PMID:26586965

  12. Colovaginoplasty in a Case of Mayer-Rokitansky-Kuster-Hauser Syndrome

    Directory of Open Access Journals (Sweden)

    Muhammad Saleem

    2014-02-01

    Full Text Available Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKHS is characterized by various abnormalities of paramesonephric duct structures; vaginal aplasia being the commonest anomaly in the spectrum. We report a 17-year-old girl; a case of MRKHS with vaginal agenesis. The cervix was present but atretic; uterus, fallopian tubes and ovaries were normal. There were no associated renal or skeletal defects. Colovaginoplasty was done to bridge the gap between uterus and introitus. Postoperatively, small part of colovaginoplasty flap became necrotic posteriorly, which was ultimately managed by insetting of labial flap.

  13. A rare case of Mayer-Rokitansky-Kuster-Hauser syndrome with multiple leiomyomas in hypoplastic uterus

    Science.gov (United States)

    Kulkarni, Maithili Mandar; Deshmukh, Sanjay D.; Hol, Kishor; Nene, Neha

    2015-01-01

    Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare disorder described as aplasia or hypoplasia of uterus and vagina due to an early arrest in development of mullerian ducts. Women with this syndrome are characterized by the presence of 46 XX karyotype, normal female secondary sex characters, normal ovarian functions, and underdeveloped vagina. The presence of leiomyoma in MRKH syndrome is very rare, and only few cases have been reported in the literature. Here, we report a case of MRKH syndrome with multiple leiomyomas originating from the rudimentary horn of uterus in 25 years married, phenotypically female patient. PMID:26752861

  14. Mayer-Rokitansky-Kuster-Hauser syndrome type II: A rare case

    Directory of Open Access Journals (Sweden)

    Anand Pai

    2013-01-01

    Full Text Available Mayer-Rokitansky-Kuster-Hauser (MRKH is a malformation complex comprising absent vagina and absent or rudimentary uterus. MRKH syndrome may be attributed to an initial affection of the intermediate mesoderm consequently leading (by the end of the 4 th week of fetal life to an alteration of the blastema of the cervicothoracicsomites and the pronephricducts. These latter subsequently induce the differentiation of the mesonephric and then the Wolffian and Mullerian ducts. There are very sparse such cases reported. We present a case of type II MRKH or Mullerian renal cervical somite association (i.e., Mullerian duct aplasia, renal dysplasia, and cervical somite anomalies.

  15. El síndrome de Kallmann. Correlación fenotipo-genotípica.

    OpenAIRE

    García Piñero, Alfonso José

    2015-01-01

    El Síndrome de Kallmann (SK) es una enfermedad genética del desarrollo, que asocia un hipogonadismo hipogonadotrópico (HH) congénito con pérdida total (anosmia) o parcial (hiposmia) del olfato. La alteración olfativa es secundaria a la aplasia o hipoplasia de las estructuras olfatorias (bulbos, tractos y surcos cerebrales olfatorios). El HH se debe a la deficiencia en la hormona liberadora de gonadotropinas hipotalámica (GnRH) como resultado del fallo en la migración de las neuronas productor...

  16. Unilateral agenesis of the abdominal wall musculature: An early muscle deficiency.

    Science.gov (United States)

    Gerard-Blanluet, Marion; Port-Lis, Marylin; Baumann, Clarisse; Perrin-Sabourin, Laurence; Ebrad, Patrick; Audry, Georges; Delezoide, Anne-Lise; Verloes, Alain

    2010-11-01

    Prune-belly sequence (PBS) usually results from early urethral obstruction. In rare cases, PBS seems to be due to a faulty primary development of the parietal mesenchyme leading to underdevelopment of the abdominal wall musculature, and disorganization of the smooth muscles in the urinary tract. We report on two patients with segmental, unilateral wall musculature deficiency associated with homolateral agenesis of ribs. One patient also had hemivertebrae and the other one ipsilateral diaphragmatic eventration and aplasia cutis. This combination of anomalies may represent a localized deficiency in the development of somitic mesoderm mesenchyme during early embryogenesis. PMID:20949627

  17. [Non-steroidal antirheumatics: side-effects and interactions].

    Science.gov (United States)

    Felder, M

    1982-08-28

    Side effects of non-steroidal antirheumatic drugs (NSAD) may occur in any organ system, since the prostaglandins, the synthesis of which is inhibited by NSAD, play a role in numerous adverse cellular processes throughout the body. Besides these physiologic regulations there are adverse effects of NSAD, such as bone marrow aplasia, of unexplained etiology. The interactions of NSAD are of clinical relevance in drug types such as the salicylates, pyrazolons and fenamic acids (e.g. interactions with cumarin derivatives). The clinically relevant interactions of NSAD are discussed in detail. PMID:6982512

  18. A Narrow Internal Auditory Canal with Duplication in a Patient with Congenital Sensorineural Hearing Loss

    International Nuclear Information System (INIS)

    A narrow internal auditory canal (IAC) with duplication is a rare anomaly of the temporal bone. It is associated with congenital sensorineural hearing loss. Aplasia or hypoplasia of the vestibulocochlear nerve may cause the hearing loss. We present an unusual case of an isolated narrow IAC with duplication that was detected by a CT scan. In this case, the IAC was divided by a bony septum into an empty stenotic inferoposterior portion and a large anterosuperior portion containing the facial nerve that was clearly delineated on MRI

  19. Ectrodactilia em cão (Canis domestica Ectrodactilia in dog (Canis domestica

    Directory of Open Access Journals (Sweden)

    Daniela Oliveira

    2002-12-01

    Full Text Available O presente trabalho relata o caso de uma cadela sem raça definida, adulta, com deformidade na região distal do membro torácico esquerdo, a qual consistia de duplicidade do osso acessório do carpo, aplasia do primeiro carpiano, ausência dos ligamentos interósseos entre o terceiro e o quarto dígitos, alterações ósseas no quarto dígito e presença de um dígito supranumerário incompleto adjacente ao quarto dígito. Após análise dos defeitos concluiu-se tratar de uma malformação congênita, hereditária em cães, denominada ectrodactilia, associada à existência de um dígito supranumerário.This paper describes a case of an adult mongrel bitch with a deformity in the distal area of the left forelimb, which was based on duplicity of the accessory carpal bone, aplasia of the first carpal bone, nonexistence of the interosseus ligament between digits 3 and 4, bony alterations in digit 4 and presence of an incomplete supernumerary digit adjacent to digit 4. After analysis of defects it was concluded to be a hereditary congenital malformation named ectrodactyly, associated to the existence of a supernumerary digit.

  20. Prenatal Diagnosis of Bilateral Ectrodactyly and Radial Agenesis Associated with Trisomy 10 Mosaicism

    Directory of Open Access Journals (Sweden)

    Jonathan Lévy

    2013-01-01

    Full Text Available Ectrodactyly or split hand and foot malformations (SHFMs are rare malformations of the limbs, characterized by median clefts of the hands and feet, syndactyly, and aplasia and/or hypoplasia of the phalanges. They represent a clinically and genetically heterogeneous disorder, with both sporadic and familial cases. Most of the genomic rearrangements identified to date in some forms of SHFM are autosomal dominant traits, involving various chromosome regions. Bilateral radial ray defects comprise also a large heterogenous group of disorders, including trisomy 18, Fanconi anemia, and thrombocytopenia-absent-radius syndrome, not commonly associated with ectrodactyly. The present paper describes a case of ectrodactyly associated with bilateral radial ray defects, diagnosed in the first trimester of pregnancy, in a fetus affected by trisomy 10. Only four cases of sporadic and isolated ectrodactyly, diagnosed by ultrasonography between 14 and 22 weeks’ gestation, have been reported. To our knowledge, the present case is the first report of mosaic trisomy 10 associated with SHFM and radial aplasia. Trisomy 10 is a rare lethal chromosomal abnormality, most frequently found in abortion products. Only six liveborn mosaic trisomy 10 infants, with severe malformations, dead in early infancy, have been reported. A severe clinical syndrome can be defined, comprising ear abnormalities, cleft lip/palate, malformations of eyes, heart, and kidneys, and deformity of hands and feet and most often associated with death neonatally or in early infancy.