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  1. Predicting outcomes in organophosphate poisoning based on APACHE II and modified APACHE II scores.

    Science.gov (United States)

    Eizadi-Mood, N; Saghaei, M; Jabalameli, M

    2007-07-01

    The aim of this study was to evaluate the scores of the Acute Physiology and Chronic Health Evaluation (APACHE) II and a modified APACHE II system (MAS), without parameters of biochemical tests; and to find prognostic value of individual elements of the APACHE II and MAS in predicting outcomes in organophosphate (OP) poisoning. Data were collected from 131 patients. The median (25th-75th percentiles) of APACHE II score for survivors without intubation were found to be lower than those of non survivors or survivors with intubation and ventilation, [4 (1-7); versus 17.5 (7.8-29), and 13.5 (7.8-16.3)]. Logistic regression analysis identified white blood cell (WBC), potassium, Glasgow coma scale (GCS), age and sodium in APACHE II; GCS and mean arterial pressure in MAS system as prognostically valuable. There was no statistically significance difference between APACHE II and MAS scores in terms of area under Receiver Operating Characteristic Curve [(0.902, 95% confidence interval: (0.837-0.947) for APACHE II), and (0.892, 95% confidence interval: (0.826-0.940) for MAS); P=0.74) to predict need for intubation. It is concluded usage of MAS facilitates the prognostication of the OP poisoned patients due to simplicity, less time-consuming and effectiveness in an emergency situation.

  2. Use of APACHE II and SAPS II to predict mortality for hemorrhagic and ischemic stroke patients.

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    Moon, Byeong Hoo; Park, Sang Kyu; Jang, Dong Kyu; Jang, Kyoung Sool; Kim, Jong Tae; Han, Yong Min

    2015-01-01

    We studied the applicability of the Acute Physiology and Chronic Health Evaluation II (APACHE II) and Simplified Acute Physiology Score II (SAPS II) in patients admitted to the intensive care unit (ICU) with acute stroke and compared the results with the Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS). We also conducted a comparative study of accuracy for predicting hemorrhagic and ischemic stroke mortality. Between January 2011 and December 2012, ischemic or hemorrhagic stroke patients admitted to the ICU were included in the study. APACHE II and SAPS II-predicted mortalities were compared using a calibration curve, the Hosmer-Lemeshow goodness-of-fit test, and the receiver operating characteristic (ROC) curve, and the results were compared with the GCS and NIHSS. Overall 498 patients were included in this study. The observed mortality was 26.3%, whereas APACHE II and SAPS II-predicted mortalities were 35.12% and 35.34%, respectively. The mean GCS and NIHSS scores were 9.43 and 21.63, respectively. The calibration curve was close to the line of perfect prediction. The ROC curve showed a slightly better prediction of mortality for APACHE II in hemorrhagic stroke patients and SAPS II in ischemic stroke patients. The GCS and NIHSS were inferior in predicting mortality in both patient groups. Although both the APACHE II and SAPS II systems can be used to measure performance in the neurosurgical ICU setting, the accuracy of APACHE II in hemorrhagic stroke patients and SAPS II in ischemic stroke patients was superior.

  3. Predicting hospital mortality using APACHE II scores in neurocritically ill patients: a prospective study.

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    Su, Ying-Ying; Li, Xia; Li, Si-jie; Luo, Rong; Ding, Jian-ping; Wang, Lin; Cao, Gui-hua; Wang, Dong-yu; Gao, Jin-xia

    2009-09-01

    Four versions of Acute Physiology and Chronic Health Evaluation are limited in predicting hospital mortality for neurocritically ill patients. This prospective study aimed to develop and assess the accuracy of a modified APACHE II model in predicting mortality in neurologic intensive care unit (N-ICU). A total of 653 patients entered the study. APACHE II scores on admission, and worst 24-, 48-, and 72-h scores were obtained. Neurologic diagnoses on admission were classified into five categories: cerebral infarction, intracranial hemorrhage, neurologic infection, neuromuscular disease, and other neurologic diseases. We developed a modified APACHE II model based on the variables of the 72-h APACHE II score and disease category using a multivariate logistic regression procedure to estimate probability of death. We assessed the calibration and discrimination of the modified APACHE II model using the Hosmer-Lemeshow goodness-of-fit chi-squared statistic and area under the receiver operating characteristic curve (AU-ROC). The modified APACHE II model had good discrimination (AU-ROC = 0.88) and calibration (Hosmer-Lemeshow statistic: chi (2) = 3.707, P = 0.834). The discrimination of the 72-h APACHE II score for cerebral infarction, intracerebral hemorrhage, and neurologic infection was satisfactory, with AU-ROC of 0.858, 0.863, and 1.000, respectively, but it was poor in discriminating for the categories of other neurologic diseases and neuromuscular disease. The results showed that our modified APACHE II model can accurately predict hospital mortality for patients in N-ICU. It is more applicable to clinical practice than the previous model because of its simplicity and ease of use.

  4. Predictive value of SAPS II and APACHE II scoring systems for patient outcome in a medical intensive care unit

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    Amina Godinjak

    2016-11-01

    Full Text Available Objective. The aim is to determine SAPS II and APACHE II scores in medical intensive care unit (MICU patients, to compare them for prediction of patient outcome, and to compare with actual hospital mortality rates for different subgroups of patients. Methods. One hundred and seventy-four patients were included in this analysis over a oneyear period in the MICU, Clinical Center, University of Sarajevo. The following patient data were obtained: demographics, admission diagnosis, SAPS II, APACHE II scores and final outcome. Results. Out of 174 patients, 70 patients (40.2% died. Mean SAPS II and APACHE II scores in all patients were 48.4±17.0 and 21.6±10.3 respectively, and they were significantly different between survivors and non-survivors. SAPS II >50.5 and APACHE II >27.5 can predict the risk of mortality in these patients. There was no statistically significant difference in the clinical values of SAPS II vs APACHE II (p=0.501. A statistically significant positive correlation was established between the values of SAPS II and APACHE II (r=0.708; p=0.001. Patients with an admission diagnosis of sepsis/septic shock had the highest values of both SAPS II and APACHE II scores, and also the highest hospital mortality rate of 55.1%. Conclusion. Both APACHE II and SAPS II had an excellent ability to discriminate between survivors and non-survivors. There was no significant difference in the clinical values of SAPS II and APACHE II. A positive correlation was established between them. Sepsis/septic shock patients had the highest predicted and observed hospital mortality rate.

  5. A comparison of Child-Pugh, APACHE II and APACHE III scoring systems in predicting hospital mortality of patients with liver cirrhosis

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    Romanos John

    2003-05-01

    Full Text Available Abstract Background The aim of this study was to assess the prognostic accuracy of Child-Pugh and APACHE II and III scoring systems in predicting short-term, hospital mortality of patients with liver cirrhosis. Methods 200 admissions of 147 cirrhotic patients (44% viral-associated liver cirrhosis, 33% alcoholic, 18.5% cryptogenic, 4.5% both viral and alcoholic were studied prospectively. Clinical and laboratory data conforming to the Child-Pugh, APACHE II and III scores were recorded on day 1 for all patients. Discrimination was evaluated using receiver operating characteristic (ROC curves and area under a ROC curve (AUC. Calibration was estimated using the Hosmer-Lemeshow goodness-of-fit test. Results Overall mortality was 11.5%. The mean Child-Pugh, APACHE II and III scores for survivors were found to be significantly lower than those of nonsurvivors. Discrimination was excellent for Child-Pugh (ROC AUC: 0.859 and APACHE III (ROC AUC: 0.816 scores, and acceptable for APACHE II score (ROC AUC: 0.759. Although the Hosmer-Lemeshow statistic revealed adequate goodness-of-fit for Child-Pugh score (P = 0.192, this was not the case for APACHE II and III scores (P = 0.004 and 0.003 respectively Conclusion Our results indicate that, of the three models, Child-Pugh score had the least statistically significant discrepancy between predicted and observed mortality across the strata of increasing predicting mortality. This supports the hypothesis that APACHE scores do not work accurately outside ICU settings.

  6. Predicting outcome after traumatic brain injury: development of prognostic scores based on the IMPACT and the APACHE II.

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    Raj, Rahul; Siironen, Jari; Kivisaari, Riku; Hernesniemi, Juha; Skrifvars, Markus B

    2014-10-15

    Prediction models are important tools for heterogeneity adjustment in clinical trials and for the evaluation of quality of delivered care to patients with traumatic brain injury (TBI). We sought to improve the predictive performance of the IMPACT (International Mission for Prognosis and Analysis of Clinical Trials) prognostic model by combining it with the APACHE II (Acute Physiology and Chronic Health Evaluation II) for 6-month outcome prediction in patients with TBI treated in the intensive care unit. A total of 890 patients with TBI admitted to a large urban level 1 trauma center in 2009-2012 comprised the study population. The IMPACT and the APACHE II scores were combined using binary logistic regression. A randomized, split-sample technique with secondary bootstrapping was used for model development and internal validation. Model performance was assessed by discrimination (by area under the curve [AUC]), calibration, precision, and net reclassification improvement (NRI). Overall 6-month mortality was 22% and unfavorable neurological outcome 47%. The predictive power of the new combined IMPACT-APACHE II models was significantly superior, compared to the original IMPACT models (AUC, 0.81-0.82 vs. 0.84-0.85; p0.05). However, NRI showed a significant improvement in risk stratification of patients with unfavorable outcome by the IMPACT-APACHE II models, compared to the original models (NRI, 5.4-23.2%; pAPACHE II with the IMPACT, improved 6-month outcome predictive performance is achieved. This may be applicable for heterogeneity adjustment in forthcoming TBI studies.

  7. APACHE II score, rather than cardiac function, may predict poor prognosis in patients with stress-induced cardiomyopathy.

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    Joe, Byung-Hyun; Jo, Uk; Kim, Hyun-Soo; Park, Chang-Bum; Hwang, Hui-Jeong; Sohn, Il-Suk; Jin, Eun-Sun; Cho, Jin-Man; Park, Jeong-Hwan; Kim, Chong-Jin

    2012-01-01

    While the disease course of stress-induced cardiomyopathy (SIC) is usually benign, it can be fatal. The prognostic factors to predict poorer outcome are not well established, however. We analyzed the Acute Physiology And Chronic Health Evaluation (APACHE) II score to assess its value for predicting poor prognosis in patients with SIC. Thirty-seven consecutive patients with SIC were followed prospectively during their hospitalization. Clinical factors, including APACHE II score, coronary angiogram, echocardiography and cardiac enzymes at presentation were analyzed. Of the 37 patients, 27 patients (73%) were women. The mean age was 66.1 ± 15.6 yr, and the most common presentation was chest pain (38%). Initial echocardiographic left ventricular ejection fraction (EF) was 42.5% ± 9.3%, and the wall motion score index (WMSI) was 1.9 ± 0.3. Six patients (16%) expired during the follow-up period of hospitalization. Based on the analysis of characteristics and clinical factors, the only predictable variable in prognosis was APACHE II score. The patients with APACHE II score greater than 20 had tendency to expire than the others (P = 0.001). Based on present study, APACHE II score more than 20, rather than cardiac function, is associated with mortality in patients with SIC.

  8. The performance of customised APACHE II and SAPS II in predicting mortality of mixed critically ill patients in a Thai medical intensive care unit.

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    Khwannimit, B; Bhurayanontachai, R

    2009-09-01

    The aim of this study was to evaluate and compare the performance of customised Acute Physiology and Chronic Health Evaluation HII (APACHE II) and Simplified Acute Physiology Score HII (SAPS II) in predicting hospital mortality of mixed critically ill Thai patients in a medical intensive care unit. A prospective cohort study was conducted over a four-year period. The subjects were randomly divided into calibration and validation groups. Logistic regression analysis was used for customisation. The performance of the scores was evaluated by the discrimination, calibration and overall fit in the overall group and across subgroups in the validation group. Two thousand and forty consecutive intensive care unit admissions during the study period were split into two groups. Both customised models showed excellent discrimination. The area under the receiver operating characteristic curve of the customised APACHE II was greater than the customised SAPS II (0.925 and 0.892, P APACHE II in overall populations and various subgroups but insufficient calibration for the customised SAPS II. The customised SAPS II showed good calibration in only the younger, postoperative and sepsis patients subgroups. The overall performance of the customised APACHE II was better than the customised SAPS II (Brier score 0.089 and 0.109, respectively). Our results indicate that the customised APACHE II shows better performance than the customised SAPS II in predicting hospital mortality and could be used to predict mortality and quality assessment in our unit or other intensive care units with a similar case mix.

  9. Apache, Vol. II.

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    Bodiroga, Ronald, Comp.; And Others

    The short stories, poems, songs, and cultural descriptions about American Indians (volume 2 of two) are the result of a combined effort of the 7th grade students of Rice School District (Sacaton, Arizona), their teacher, and the parents and friends of the students of the San Carlos Apache Indian Reservation (Arizona). The 24 student contributors…

  10. Comparison of BISAP, Ranson, MCTSI, and APACHE II in Predicting Severity and Prognoses of Hyperlipidemic Acute Pancreatitis in Chinese Patients

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    Lixin Yang; Jing Liu; Yun Xing; Lichuan Du; Jing Chen; Xin Liu; Jianyu Hao

    2016-01-01

    In recent years, with the developing of living standard, hyperlipidemia becomes the second major reason of acute pancreatitis. It is important to predict the severity and prognosis at early stage of hyperlipidemic acute pancreatitis (HLAP). We compared the BISAP, Ranson, MCTSI, and APACHE II scoring system in predicting MSAP and SAP, local complications, and mortality of HLAP. A total of 326 diagnosed hyperlipidemic acute pancreatitis patients from August 2006 to July 2015 were studied retros...

  11. Comparison of BISAP, Ranson, MCTSI, and APACHE II in Predicting Severity and Prognoses of Hyperlipidemic Acute Pancreatitis in Chinese Patients.

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    Yang, Lixin; Liu, Jing; Xing, Yun; Du, Lichuan; Chen, Jing; Liu, Xin; Hao, Jianyu

    2016-01-01

    In recent years, with the developing of living standard, hyperlipidemia becomes the second major reason of acute pancreatitis. It is important to predict the severity and prognosis at early stage of hyperlipidemic acute pancreatitis (HLAP). We compared the BISAP, Ranson, MCTSI, and APACHE II scoring system in predicting MSAP and SAP, local complications, and mortality of HLAP. A total of 326 diagnosed hyperlipidemic acute pancreatitis patients from August 2006 to July 2015 were studied retrospectively. Our result showed that all four scoring systems can be used to predict the severity, local complications, and mortality of HLAP. Ranson did not have significant advantage in predicting severity and prognosis of HLAP compared to other three scoring systems. APACHE II was the best in predicting severity of HLAP, but it had shortcoming in predicting local complications. MCTSI had outstanding performance in predicting local complications, but it was poor in predicting severity and mortality. BISAP score had high accuracy in assessment of severity, local complications, and mortality of HLAP, but the accuracy still needs to be improved in the future.

  12. Comparison of BISAP, Ranson, MCTSI, and APACHE II in Predicting Severity and Prognoses of Hyperlipidemic Acute Pancreatitis in Chinese Patients

    Directory of Open Access Journals (Sweden)

    Lixin Yang

    2016-01-01

    Full Text Available In recent years, with the developing of living standard, hyperlipidemia becomes the second major reason of acute pancreatitis. It is important to predict the severity and prognosis at early stage of hyperlipidemic acute pancreatitis (HLAP. We compared the BISAP, Ranson, MCTSI, and APACHE II scoring system in predicting MSAP and SAP, local complications, and mortality of HLAP. A total of 326 diagnosed hyperlipidemic acute pancreatitis patients from August 2006 to July 2015 were studied retrospectively. Our result showed that all four scoring systems can be used to predict the severity, local complications, and mortality of HLAP. Ranson did not have significant advantage in predicting severity and prognosis of HLAP compared to other three scoring systems. APACHE II was the best in predicting severity of HLAP, but it had shortcoming in predicting local complications. MCTSI had outstanding performance in predicting local complications, but it was poor in predicting severity and mortality. BISAP score had high accuracy in assessment of severity, local complications, and mortality of HLAP, but the accuracy still needs to be improved in the future.

  13. Predictive ability of the ISS, NISS, and APACHE II score for SIRS and sepsis in polytrauma patients.

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    Mica, L; Furrer, E; Keel, M; Trentz, O

    2012-12-01

    Systemic inflammatory response syndrome (SIRS) and sepsis as causes of multiple organ dysfunction syndrome (MODS) remain challenging to treat in polytrauma patients. In this study, the focus was set on widely used scoring systems to assess their diagnostic quality. A total of 512 patients (mean age: 39.2 ± 16.2, range: 16-88 years) who had an Injury Severity Score (ISS) ≥17 were included in this retrospective study. The patients were subdivided into four groups: no SIRS, slight SIRS, severe SIRS, and sepsis. The ISS, New Injury Severity Score (NISS), Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, and prothrombin time were collected at admission. The Kruskal-Wallis test and χ(2)-test, multinomial regression analysis, and kernel density estimates were performed. Receiver operating characteristic (ROC) analysis is reported as the area under the curve (AUC). Data were considered as significant if p < 0.05. All variables were significantly different in all groups (p < 0.001). The odds ratio increased with increasing SIRS severity for NISS (slight vs. no SIRS, 1.06, p = 0.07; severe vs. no SIRS, 1.07, p = 0.04; and sepsis vs. no SIRS, 1.11, p = 0.0028) and APACHE II score (slight vs. no SIRS, 0.97, p = 0.44; severe vs. no SIRS, 1.08, p = 0.02; and sepsis vs. no SIRS, 1.12, p = 0.0028). ROC analysis revealed that the NISS (slight vs. no SIRS, AUC 0.61; severe vs. no SIRS, AUC 0.67; and sepsis vs. no SIRS, AUC 0.77) and APACHE II score (slight vs. no SIRS, AUC 0.60; severe vs. no SIRS, AUC 0.74; and sepsis vs. no SIRS, AUC 0.82) had the best predictive ability for SIRS and sepsis. Quick assessment with the NISS or APACHE II score could preselect possible candidates for sepsis following polytrauma and provide guidance in trauma surgeons' decision-making.

  14. Efficacy of the APACHE II score at ICU discharge in predicting post-ICU mortality and ICU readmission in critically ill surgical patients.

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    Lee, H; Lim, C W; Hong, H P; Ju, J W; Jeon, Y T; Hwang, J W; Park, H P

    2015-03-01

    In this study, we evaluated the efficacy of the discharge Acute Physiology and Chronic Health Evaluation (APACHE) II score in predicting post-intensive care unit (ICU) mortality and ICU readmission during the same hospitalisation in a surgical ICU. Of 1190 patients who were admitted to the ICU and stayed >48 hours between October 2007 and March 2010, 23 (1.9%) died and 86 (7.2%) were readmitted after initial ICU discharge, with 26 (3.0%) admitted within 48 hours. The area under the receiver operating characteristics curve of the discharge and admission APACHE II scores in predicting in-hospital mortality was 0.631 (95% confidence interval [CI] 0.603 to 0.658) and 0.669 (95% CI 0.642 to 0.696), respectively (P=0.510). The area under the receiver operating characteristics curve of discharge and admission APACHE II scores for predicting all forms of readmission was 0.606 (95% CI 0.578 to 0.634) and 0.574 (95% CI 0.545 to 0.602), respectively (P=0.316). The area under the receiver operating characteristics curve of discharge APACHE II score in predicting early ICU readmissions was, however, higher than that of admission APACHE II score (0.688 [95% CI 0.660 to 0.714] versus 0.505 [95% CI 0.476 to 0.534], P=0.001). The discharge APACHE II score (odds ratio [OR] 1.1, 95% CI 1.01 to 1.22, P=0.024), unplanned ICU readmission (OR 20.0, 95% CI 7.6 to 53.1, P=0.001), eosinopenia at ICU discharge (OR 6.0, 95% CI 1.34 to 26.9, P=0.019), and hospital length-of-stay before ICU admission (OR 1.02, 95% CI 1.01 to 1.03, P=0.021) were significant independent factors in predicting post-ICU mortality. This study suggests that the discharge APACHE II score may be useful in predicting post-ICU mortality and is superior to the admission APACHE II score in predicting early ICU readmission in surgical ICU patients.

  15. Is SAPS 3 better than APACHE II at predicting mortality in critically ill transplant patients?

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    Vanessa M. de Oliveira

    2013-01-01

    Full Text Available OBJECTIVES: This study compared the accuracy of the Simplified Acute Physiology Score 3 with that of Acute Physiology and Chronic Health Evaluation II at predicting hospital mortality in patients from a transplant intensive care unit. METHOD: A total of 501 patients were enrolled in the study (152 liver transplants, 271 kidney transplants, 54 lung transplants, 24 kidney-pancreas transplants between May 2006 and January 2007. The Simplified Acute Physiology Score 3 was calculated using the global equation (customized for South America and the Acute Physiology and Chronic Health Evaluation II score; the scores were calculated within 24 hours of admission. A receiver-operating characteristic curve was generated, and the area under the receiver-operating characteristic curve was calculated to identify the patients at the greatest risk of death according to Simplified Acute Physiology Score 3 and Acute Physiology and Chronic Health Evaluation II scores. The Hosmer-Lemeshow goodness-of-fit test was used for statistically significant results and indicated a difference in performance over deciles. The standardized mortality ratio was used to estimate the overall model performance. RESULTS: The ability of both scores to predict hospital mortality was poor in the liver and renal transplant groups and average in the lung transplant group (area under the receiver-operating characteristic curve = 0.696 for Simplified Acute Physiology Score 3 and 0.670 for Acute Physiology and Chronic Health Evaluation II. The calibration of both scores was poor, even after customizing the Simplified Acute Physiology Score 3 score for South America. CONCLUSIONS: The low predictive accuracy of the Simplified Acute Physiology Score 3 and Acute Physiology and Chronic Health Evaluation II scores does not warrant the use of these scores in critically ill transplant patients.

  16. Evaluation of APACHE II for cost containment and quality assurance.

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    Civetta, J M; Hudson-Civetta, J A; Nelson, L D

    1990-01-01

    APACHE II (an acronym formed from acute physiology score and chronic health evaluation) has been proposed to limit intensive care unit (ICU) admissions ('cost containment') and to judge outcome ('quality assurance') of surgical patients. To judge its performance, a 6-month study of 372 surgical ICU patients was performed. When patients were divided by mean duration of stay, mortality rates rose from 1% (short stay) to 19% (long stay) (p less than 0.001) for patients with APACHE II scores less than 10, but decreased from 94% (short stay) to 60% (long stay) (p less than 0.01) for patients with APACHE II scores more than 24. Exclusion of patients by high or low APACHE scores would 'save' 6% of ICU days but risk increasing morbidity, hospital costs, and deaths. Grouped APACHE II scores did not correlate with total hospital charges (r = 0.05, p = 0.89) or ICU days used (r = 0.42, p = 0.17). Grouping by APACHE II score and duration of ICU stay showed neither symmetry nor uniformity of mortality rates. Surgical patients would not be well served by APACHE II for quality assurance or cost containment. PMID:2396881

  17. Evaluation of nosocomial infection risk using APACHE II scores in the neurological intensive care unit.

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    Li, Hai-Ying; Li, Shu-Juan; Yang, Nan; Hu, Wen-Li

    2014-08-01

    To evaluate the feasibility and accuracy of using the Acute Physiology, Age and Chronic Health Evaluation II (APACHE II) scoring system for predicting the risk of nosocomial infection in the neurological intensive care unit (NICU), 216 patients transferred to NICU within 24hours of admission were retrospectively evaluated. Based on admission APACHE II scores, they were classified into three groups, with higher APACHE II scores representing higher infectious risk. The device utilization ratios and device-associated infection ratios of NICU patients were analyzed and compared with published reports on patient outcome. Statistical analysis of nosocomial infection ratios showed obvious differences between the high-risk, middle-risk and low-risk groups (pAPACHE II model in predicting the risk of nosocomial infection was 0.81, which proved to be reliable and consistent with the expectation. In addition, we found statistical differences in the duration of hospital stay (patient-days) and device utilization (device-days) between different risk groups (pAPACHE II scoring system was validated in predicting the risk of nosocomial infection, duration of patient-days and device-days, and providing accurate assessment of patients' condition, so that appropriate prevention strategies can be implemented based on admission APACHE II scores.

  18. Performance assessment of the SOFA, APACHE II scoring system, and SAPS II in intensive care unit organophosphate poisoned patients.

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    Kim, Yong Hwan; Yeo, Jung Hoon; Kang, Mun Ju; Lee, Jun Ho; Cho, Kwang Won; Hwang, SeongYoun; Hong, Chong Kun; Lee, Young Hwan; Kim, Yang Weon

    2013-12-01

    This study assessed the ability of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology, Chronic Health Evaluation (APACHE) II scoring systems, as well as the Simplified Acute Physiology Score (SAPS) II method to predict group mortality in intensive care unit (ICU) patients who were poisoned with organophosphate. The medical records of 149 organophosphate poisoned patients admitted to the ICU from September 2006 to December 2012 were retrospectively examined. The SOFA, APACHE II, and SAPS II were calculated based on initial laboratory data in the Emergency Department, and during the first 24 hr of ICU admission. The probability of death was calculated for each patient based on the SOFA score, APACHE II score, and SAPS II equations. The ability to predict group mortality by the SOFA score, APACHE II score, and SAPS II method was assessed using two by two decision matrices and receiver operating characteristic (ROC) curve analysis. A total of 131 patients (mean age, 61 yr) were enrolled. The sensitivities, specificities, and accuracies were 86.2%, 82.4%, and 83.2% for the SOFA score, respectively; 65.5%, 68.6%, and 67.9% for the APACHE II scoring system, respectively; and 86.2%, 77.5%, and 79.4% for the SAPS II, respectively. The areas under the curve in the ROC curve analysis for the SOFA score, APACHE II scoring system, and SAPS II were 0.896, 0.716, and 0.852, respectively. In conclusion, the SOFA, APACHE II, and SAPS II have different capability to discriminate and estimate early in-hospital mortality of organophosphate poisoned patients. The SOFA score is more useful in predicting mortality, and easier and simpler than the APACHE II and SAPS II.

  19. Correlation of APACHE II and SOFA scores with length of stay in various surgical intensive care units.

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    Milić, Morena; Goranović, Tatjana; Holjevac, Jadranka Katancić

    2009-09-01

    The aim of this study was to evaluate the usefulness of using Acute Physiology and Chronic Health Evaluation (APACHE) II score and Sequential Organ Failure Assessment (SOFA) score as the predictors of length of stay (LOS) in various surgical intensive care units (ICUs) and to test the hypothesis that the significance of scoring for predicting LOS is greater in specialized surgical ICUs. We scored patients in a non-specialized general surgical ICU (n = 328) and in a specialized cardiosurgical ICU (n = 158) consecutively on admission (APACHE II-1st day; SOFA-1st day) and on third day of stay (APACHE II-3rd day; SOFA-3rd day) in a 4-month period. LOS and APACHE II/SOFA scores were significantly correlated both on admission and on third day of stay in the general surgical ICU (APACHE II-1st day r = 0.289; SOFA-1st day r = 0.306; APACHE II-3rd day r = 0.728; SOFA-3rd day r = 0.725). LOS and APACHE II on admission were not significantly correlated in the cardiosurgical ICU (APACHE II-1st day r = 0.092), while SOFA on admission and APACHE II and SOFA on third day were significantly correlated (SOFA-1st day r = 0.258; APACHE II-3rd day r = 0.716; SOFA-3rd day r = 0.719). Usefulness of scoring for predicting LOS in ICU varied between different surgical ICUs. Contrary to our hypothesis, scoring had greater value for predicting LOS in the non-specialized general surgical ICU. APACHE II score on admission had no value for predicting LOS in the cardiosurgical ICU.

  20. Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI Scores, IL-6, CRP, and Procalcitonin in Predicting Severity, Organ Failure, Pancreatic Necrosis, and Mortality in Acute Pancreatitis

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    Ajay K. Khanna

    2013-01-01

    Full Text Available Background. Multifactorial scorings, radiological scores, and biochemical markers may help in early prediction of severity, pancreatic necrosis, and mortality in patients with acute pancreatitis (AP. Methods. BISAP, APACHE-II, MOSS, and SIRS scores were calculated using data within 24 hrs of admission, whereas Ranson and Glasgow scores after 48 hrs of admission; CTSI was calculated on day 4 whereas IL-6 and CRP values at end of study. Predictive accuracy of scoring systems, sensitivity, specificity, and positive and negative predictive values of various markers in prediction of severe acute pancreatitis, organ failure, pancreatic necrosis, admission to intensive care units and mortality were calculated. Results. Of 72 patients, 31 patients had organ failure and local complication classified as severe acute pancreatitis, 17 had pancreatic necrosis, and 9 died (12.5%. Area under curves for Ranson, Glasgow, MOSS, SIRS, APACHE-II, BISAP, CTSI, IL-6, and CRP in predicting SAP were 0.85, 0.75, 0.73, 0.73, 0.88, 0.80, 0.90, and 0.91, respectively, for pancreatic necrosis 0.70, 0.64, 0.61, 0.61, 0.68, 0.61, 0.75, 0.86, and 0.90, respectively, and for mortality 0.84, 0.83, 0.77, 0.76, 0.86, 0.83, 0.57, 0.80, and 0.75, respectively. Conclusion. CRP and IL-6 have shown a promising result in early detection of severity and pancreatic necrosis whereas APACHE-II and Ranson score in predicting AP related mortality in this study.

  1. APACHE II AS AN INDICATOR OF VENTILATOR-ASSOCIATED PNEUMONIA (VAP

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    Kelser de Souza Kock

    2015-07-01

    Full Text Available Background and objectives: strategies for risk stratification in severe pathologies are extremely important. The aim of this study was to analyze the accuracy of the APACHE II score as an indicator of Ventilator-Associated Pneumonia (VAP in ICU patient sat Hospital Nossa Senhora da Conceição (HNSC Tubarão-SC. Methods: It was conducted a prospective cohort study with 120 patients admitted between March and August 2013, being held APACHE II in the first 24 hours of mechanical ventilation (MV. Patients were followed until the following gout comes: discharge or death. It was also analyzed the cause of ICU admission, age, gender, days of mechanical ventilation, length of ICU and outcome. Results: The incidence of VAP was 31.8% (38/120. Two variables showed a relative riskin the development of VAP, APACHE II above average (RR = 1,62; IC 95% 1,03-2,55 and males (RR = 1,56; IC 95 % 1,18-2,08. The duration of mechanical ventilation (days above average18.4± 14.9(p =0.001, ICU stay (days above average 20.4± 15.3(p =0.003 presented the development of VAP. The accuracy of APACHE II in predicting VAP score >23, showed a sensitivity of 84% and specificity of 33%. Inrelation to death, two variables showed relative risk, age above average (RR=2.08; 95% CI =1.34 to 3.23 and ICU stay above average (RR=2.05; CI 95 =1.28 to 3.28%. Conclusion: The APACHE II score above or equal 23 might to indicate the risk of VAP. Keywords: Pneumonia, Ventilator-Associated, Intensive Care Units, APACHE. Prognosis

  2. QT dispersion and prognostication of the outcome in acute cardiotoxicities: A comparison with SAPS II and APACHE II scoring systems.

    Science.gov (United States)

    Hassanian-Moghaddam, Hossein; Amiri, Hassan; Zamani, Nasim; Rahimi, Mitra; Shadnia, Shahin; Taherkhani, Maryam

    2014-06-01

    We aimed to evaluate the efficacy of QT dispersion (QTD) in determining the outcome of the patients poisoned by cardiotoxic medications and toxins. Patients who referred to our emergency department (ED) due to acute toxicity with any cardiotoxic medication or toxin and were admitted to medical toxicology intensive care unit (MTICU) were enrolled into the study. A questionnaire containing the demographic characteristics, vital signs, laboratory tests, electrocardiographic (ECG) parameters of the first ECG taken on MTICU or ED admission, simplified acute physiology score (SAPS), and acute physiology and chronic health evaluation (APACHE) score was filled for every single patient. QTD was manually calculated. The patients were divided into two groups of survivors and non-survivors and compared. Although QTD was not significantly different between the survivors and non-survivors (P = 0.8), SAPS II and APACHE II score were so. SAPS and APACHE had the highest sensitivity and specificity in determining the patients' mortality, respectively. SAPS had the highest sensitivity, and QTD had the highest specificity in predicting the later development of the complications. SAPS II and APACHE II scoring systems are the best systems for prognostication of death in patients with acute cardiotoxic medication-induced poisonings. QTD can be successfully used for the prediction of complications.

  3. Does the RIFLE Classification Improve Prognostic Value of the APACHE II Score in Critically Ill Patients?

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    Kátia M. Wahrhaftig

    2013-01-01

    Full Text Available Introduction. The RIFLE classification defines three severity criteria for acute kidney injury (AKI: risk, injury, and failure. It was associated with mortality according to the gradation of AKI severity. However, it is not known if the APACHE II score, associated with the RIFLE classification, results in greater discriminatory power in relation to mortality in critical patients. Objective. To analyze whether the RIFLE classification adds value to the performance of APACHE II in predicting mortality in critically ill patients. Methods. An observational prospective cohort of 200 patients admitted to the ICU from July 2010 to July 2011. Results. The age of the sample was 66 (±16.7 years, 53.3% female. ICU mortality was 23.5%. The severity of AKI presented higher risk of death: class risk (RR = 1.89 CI:0.97–3.38, , grade injury (RR = 3.7 CI:1.71–8.08, , and class failure (RR = 4.79 CI:2.10–10.6, . The APACHE II had C-statistics of 0.75, 95% (CI:0.68–0.80, and 0.80 (95% CI:0.74 to 0.86, after being incorporated into the RIFLE classification in relation to prediction of death. In the comparison between AUROCs, . Conclusion. The severity of AKI, defined by the RIFLE classification, was a risk marker for mortality in critically ill patients, and improved the performance of APACHE II in predicting the mortality in this population.

  4. Comparison of two simplified severity scores (SAPS and APACHE II) for patients with acute myocardial infarction.

    Science.gov (United States)

    Moreau, R; Soupison, T; Vauquelin, P; Derrida, S; Beaucour, H; Sicot, C

    1989-05-01

    The Simplified Acute Physiology Score (SAPS), the Acute Physiology and Chronic Health Evaluation II (APACHE II), the Acute Physiology Score (APS), and the Coronary Prognostic Index (CPI), calculated within the first 24 h of ICU admission, were compared in 76 patients with acute myocardial infarction (AMI). Sixteen (21%) patients subsequently died in the ICU. The nonsurvivors had significantly higher SAPS, APACHE II, and CPI scores than the survivors. ROC curves drawn for each severity index were in a discriminating position. There were no significant differences either between the areas under the ROC curves drawn for SAPS, APACHE II, and CPI, or between the overall accuracies of these indices. APS provided less homogeneous information. We conclude that SAPS and APACHE II, two severity indices which are easy to use, assess accurately the short-term prognosis, i.e., the ICU outcome, of patients with AMI.

  5. Procalcitonin and BISAP score versus c-reactive protein and APACHE II score in early assessment of severity and outcome of acute pancreatitis

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    Bezmarević Mihailo

    2012-01-01

    Full Text Available Background/Aim. Early assessment of severity and continuous monitoring of patients are the key factors for adequate treatment of acute pancreatitis (AP. The aim of this study was to determine the value of procalcitonin (PCT and Bedside Index for Severity in Acute Pancreatitis (BISAP scoring system as prognostic markers in early stages of AP with comparison to other established indicators such as Creactive protein (CRP and Acute Physiology and Chronic Health Evaluation (APACHE II score. Methods. This prospective study included 51 patients (29 with severe AP. In the first 24 h of admission in all patients the APACHE II score and BISAP score, CRP and PCT serum concentrations were determined. The values of PCT serum concentrations and BISAP score were compared with values of CRP serum concentrations and APACHE II score, in relation to the severity and outcome of the disease. Results. Values of PCT, CRP, BISAP score and APACHE II score, measured at 24 h of admission, were significantly elevated in patients with severe form of the disease. In predicting severity of AP at 24 h of admission, sensitivity and specificity of the BISAP score were 74% and 59%, respectively, APACHE II score 89% and 69%, respectively, CRP 75% and 86%, respectively, and PCT 86% and 63%, respectively. It was found that PCT is highly significant predictor of the disease outcome (p < 0,001. Conclusion. In early assessment of AP severity, PCT has better predictive value than CRP, and similar to the APACHE II score. APACHE II score is a stronger predictor of the disease severity than BISAP score. PCT is a good predictor of AP outcome.

  6. Causes of death in intensive care patients with a low APACHE II score

    NARCIS (Netherlands)

    Berkel, A. van; Lieshout, J.v.; Hellegering, J.; Hoeven, J.G. van der; Pickkers, P.

    2012-01-01

    Background: Little is known about the actual causes of death of patients with a low APACHE II score, but iatrogenic reasons may play a role. The aim of this study was to evaluate the demographics, course of disease, and causes of death in this specific group of ICU patients. Methods: For this retros

  7. Perbandingan Validitas Sistem Penilaian APACHE II, SOFA, dan CSOFA Sebagai Prediktor Mortalitas Pasien yang Dirawat di Instalasi Rawat Intensif RSUP H. Adam Malik Medan

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    Andrias

    2017-04-01

    Full Text Available The APACHE II and SOFA scoring systems are still used as the objective instruments for predicting mortality in patients admitted to the Intensive Care Unit (ICU; however, the two are still considered less practical. CSOFA, with more practical parameters as well as a lower cost, is expected to provide better accuracy. The purpose of this study was to get a simpler, easier, and cheaper alternative, but with good accuracy, to APACHE II and SOFA as a predictor of mortality in patients admitted to the ICU of H. Adam Malik (HAM Hospital. A cross-sectional diagnostic test study was conducted in February–April 2016 at the ICU of H. Adam Malik General Hospital. A sample of 71 adult patients that met the inclusion criteria was assessed by APACHE II, SOFA, and CSOFA at the first 24 hours after treatment. The mortality was then observed at the end of treatment. Statistical analysis using 2x2 tables and receiving operating curve (ROC were used to calculate the sensitivity, specificity, positive, and negative predictive values, as well as the likelihood ratio using SPSS ver.23. CSOFA in this study presented a very good ability in predicting mortality with an Area under ROC (AuROC of 87.6% while APACHE II had a good ability in predicting mortality with an AuROC of 84.7%. SOFA had sufficient ability in predicting mortality with an AuROC of 79.1%. In conclusion, CSOFA scoring system can be used as a patient mortality predictor as an alternative to APACHE II and SOFA in the ICU.

  8. Profile and severity of the patients of intensive care units: prospective application of the APACHE II index.

    Science.gov (United States)

    De Freitas, Eliane Regina Ferreira Sernache

    2010-01-01

    This study aimed to understand the profile and severity of patients in physiotherapy treatment after their admission to the intensive care unit (ICU) by applying the APACHE II index. One hundred and forty six subjects, with a mean age of 60.5 +/- 19.2 years, were evaluated. The APACHE II index was applied in the first 24 hours to evaluate the severity and mortality risk score. Patients were monitored until hospital discharge or death. The mean APACHE II score was 20+/-7.3 with an estimated risk of death of 32.4% and observed mortality of 58.2%. The mean hospital stay was 27.8+/-25.2 days. The patients in physiotherapy at the institution studied were predominantly male, elderly, from the emergency service for treatment (non-surgical), and had clear severity, suggested by the APACHE II score and the observed mortality.

  9. APACHE IV is superior to MELD scoring system in predicting prognosis in patients after orthotopic liver transplantation.

    Science.gov (United States)

    Hu, Yueyun; Zhang, Xianling; Liu, Yuan; Yan, Jun; Li, Tiehua; Hu, Ailing

    2013-01-01

    This study aims to compare the efficiency of APACHE IV with that of MELD scoring system for prediction of the risk of mortality risk after orthotopic liver transplantation (OLT). A retrospective cohort study was performed based on a total of 195 patients admitted to the ICU after orthotopic liver transplantation (OLT) between February 2006 and July 2009 in Guangzhou, China. APACHE IV and MELD scoring systems were used to predict the postoperative mortality after OLT. The area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow C statistic were used to assess the discrimination and calibration of APACHE IV and MELD, respectively. Twenty-seven patients died during hospitalization with a mortality rate of 13.8%. The mean scores of APACHE IV and MELD were 42.32 ± 21.95 and 18.09 ± 10.55, respectively, and APACHE IV showed better discrimination than MELD; the areas under the receiver operating characteristic curve for APACHE IV and MELD were 0.937 and 0.694 (P APACHE IV was relatively high. Both models were well-calibrated (The Hosmer-Lemeshow C statistics were 1.568 and 6.818 for APACHE IV and MELD, resp.; P > 0.05 for both). The respective Youden indexes of APACHE IV, MELD, and combination of APACHE IV with MELD were 0.763, 0.430, and 0.545. The prognostic value of APACHE IV is high but still underestimates the overall hospital mortality, while the prognostic value of MELD is poor. The function of the APACHE IV is, thus, better than that of the MELD.

  10. Hubungan Nilai Mean Platelet Volume (MPV dengan Skor APACHE II sebagai Prediktor Mortalitas pada Pasien Sepsis Berat di Rumah Sakit Umum Pusat Haji Adam Malik Medan

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    M. Teguh Prihardi

    2016-12-01

    Full Text Available Severe sepsis is a general condition in the Intensive Care Unit (ICU and inpatient wards which correlates with mortality, morbidity, and high cost hospitalization. The main point of this study was to explore the possibility to use the mean platelet volume (MPV as an easier alternative score for mortality predictor in addition to APACHE II score in severe sepsis patients. This study used cross-sectional design on 76 adult severe sepsis patients in Haji Adam Malik General Hospital Medan who met inclusion criteria during the periood of October 2015 to January 2016. Data collected were MPV value and APACHE II score, which were collected the first time patient was diagnosed as having severe sepsis which was then observed for their mortality The Spearman correlation tests showed that there was a weak yet significant correlation (p=0.006 between MPV and APACHE II with r (correlation = 0.314. The MPV values in this study were unable to predict mortality (AUC ROC 58.2% (95% CI: 45.1–71.2%, p=0.223. whereas the APACHE II score has a moderate ability to predict mortality (AUC ROC 70,4% (95% CI: 58,6–82,2%, p= 0.002. The cut-off point of APACHE II was 19 with a sensitivity of 65.9% and a specificity of 65.7%, and a PPV of 69.2% and NPV of 62.2%. Therefore, based on this study the MPV score cannot be used as a mortality predictor in severe sepsis patients.

  11. A simple tool for mortality prediction in burns patients: APACHE III score and FTSA.

    Science.gov (United States)

    Moore, E C; Pilcher, D V; Bailey, M J; Cleland, H; McNamee, J

    2010-11-01

    Prediction of outcome for patients with major thermal injury is important to inform clinical decision making, alleviate individual suffering and improve hospital resource allocation. Age and burn size are widely accepted as the two largest contributors of mortality amongst burns patients. The APACHE (Acute Physiology and Chronic Health Evaluation) III-j score, which incorporates patient age, is also useful for mortality prediction, of intensive care populations. Validation for the burns specific cohort is unclear. A retrospective cohort study was performed on patients admitted to the Intensive Care Unit (ICU) via the Victorian Adult Burns Service (VABS), to compare observed mortality with burns specific markers of illness severity and APACHE III-j score. Our primary aim was to develop a mortality prediction tool for the burns population. Between January 1, 2002 and December 31, 2008, 228 patients were admitted to the ICU at The Alfred with acute burns. The mean age was 45.6 years and 81% (n=184) were male. Patients had severe injuries: the average percent TBSA (total body surface area) was 28% (IQR 10-40) and percent FTSA (full thickness surface area) was 18% (IQR 10-25). 86% (n=197) had airway involvement. Overall mortality in the 7-year period was 12% (n=27). Non-survivors were older, had larger and deeper burns, a higher incidence of deliberate self-harm, higher APACHE III-j scores and spent less time in hospital (but similar time in ICU), compared with survivors. Independent risk factors for death were percent FTSA (OR 1.03, 95% CI 1.01-1.05, p=0.01) and APACHE III-j score (OR 1.04, 95% CI 1.02-1.07, pAPACHE III-j score and percent FTSA. Prospective validation of our model on different burn populations is necessary.

  12. Initial dosing regimen of vancomycin to achieve early therapeutic plasma concentration in critically ill patients with MRSA infection based on APACHE II score.

    Science.gov (United States)

    Imaura, Masaharu; Yokoyama, Haruko; Kohata, Yuji; Kanai, Riichiro; Kohyama, Tomoki; Idemitsu, Wataru; Maki, Yuichi; Igarashi, Takashi; Takahashi, Hiroyuki; Kanno, Hiroshi; Yamada, Yasuhiko

    2016-06-01

    It is essential to assure the efficacy of antimicrobials at the initial phase of therapy. However, increasing the volume of distribution (Vd) of hydrophilic antimicrobials in critically ill patients leads to reduced antimicrobial concentration in plasma and tissue, which may adversely affect the efficacy of that therapy. The aim of the present study was to establish a theoretical methodology for setting an appropriate level for initial vancomycin therapy in individual patients based on Acute Physiology and Chronic Health Evaluation (APACHE) II score. We obtained data from patients who received intravenous vancomycin for a suspected or definitively diagnosed Gram-positive bacterial infection within 72 h after admission to the intensive care unit. The Vd and elimination half-life (t 1/2) of vancomycin values were calculated using the Bayesian method, and we investigated the relationship between them and APACHE II score. There were significant correlations between APACHE II scores and Vd/actual body weight (ABW), as well as t 1/2 (r = 0.58, p < 0.05 and r = 0.74, p < 0.01, respectively). Our results suggested that the Vd and t 1/2 of vancomycin could be estimated using the following regression equations using APACHE II score.[Formula: see text] [Formula: see text]We found that APACHE II score was a useful index for predicting the Vd and t 1/2 of vancomycin, and used that to establish an initial vancomycin dosing regimen comprised of initial dose and administration interval for individual patients.

  13. Profile and severity of the patients of intensive care units: prospective application of the APACHE II index Perfil y gravedad de los pacientes de las unidades de terapia intensiva: aplicación prospectiva del puntaje APACHE II Perfil e gravidade dos pacientes das unidades de terapia intensiva: aplicação prospectiva do escore APACHE II

    Directory of Open Access Journals (Sweden)

    Eliane Regina Ferreira Sernache de Freitas

    2010-06-01

    Full Text Available This study aimed to understand the profile and severity of patients in physiotherapy treatment after their admission to the intensive care unit (ICU by applying the APACHE II index. One hundred and forty six subjects, with a mean age of 60.5 ± 19.2 years, were evaluated. The APACHE II index was applied in the first 24 hours to evaluate the severity and mortality risk score. Patients were monitored until hospital discharge or death. The mean APACHE II score was 20±7.3 with an estimated risk of death of 32.4% and observed mortality of 58.2%. The mean hospital stay was 27.8±25.2 days. The patients in physiotherapy at the institution studied were predominantly male, elderly, from the emergency service for treatment (non-surgical, and had clear severity, suggested by the APACHE II score and the observed mortality.Este estudio tuvo como objetivo conocer el perfil y la gravedad de pacientes asistidos por la fisioterapia, después de su ingreso en las unidades de terapia intensiva (UTI, a través de la aplicación del puntaje APACHE II. Se evaluaron 146 individuos con promedio de edad de 60,5±19,2 años. El puntaje APACHE II fue aplicado en las primeras 24h para evaluar la gravedad y dar puntuación al riesgo de mortalidad. Los pacientes fueron acompañados hasta el momento del alta hospitalaria o de la muerte. El puntaje APACHE II promedio fue de 20±7,3 con riesgo estimado de muerte de 32,4% y mortalidad observada de 58,2%. El promedio de permanencia hospitalaria fue de 27,8±25,2 días. En los pacientes asistidos por la fisioterapia de la institución investigada, el predominio fue del sexo masculino, ancianos, provenientes de la atención rápida para tratamiento clínico (no quirúrgico y que presentan nítida gravedad, sugerida por el puntaje APACHE II y por la mortalidad observada.Este estudo teve como objetivo conhecer o perfil e a gravidade de pacientes assistidos pela fisioterapia, após o seu ingresso nas unidades de terapia intensiva

  14. [APACHE II and ATN-ISS in acute renal failure (ARF) in intensive care unit (ICU) and non-ICU].

    Science.gov (United States)

    Fernandes, Natáia Maria da Silva; Pinto, Patrícia dos Santos; Lacet, Thiago Bento de Paiva; Rodrigues, Dominique Fonseca; Bastos, Marcus Gomes; Stella, Sérgio Reinaldo; Cendoroglo Neto, Miguel

    2009-01-01

    Acute renal failure (ARF) remains highly prevalent with a high rate of morbidity and mortality. of this study was to compare use of the APACHE II scoring prognosis with that of the ATN-ISS to determine whether the APACHE II could be used for patients with ARF outside the ICU. For this purpose, 205 patients with ARF were accompanied in a prospective cohort. Demographic data, preexisting conditions, organ failure and characteristics of ARF were analyzed. The prognostic scores were performed with the assessment of a nephrologist. The mean age was 52 +/- 18 years, 50% were male, 69% were white, 45% were treated in ICU and 55% in other units. Mortality in the ICU group was 85% and in the non-ICU group 18%. Factors that correlated with higher mortality were more prevalent in the ICU group: age, male, hospitalization with ARF, organ failure, sepsis, septic IRA, oliguria and need of dialysis. Overall, the prognostic markers were the same for both the ICU and non-ICU groups. The discrimination with the APACHE II was similar in both, ICU and non-ICU groups and calibration was better in the non-ICU group. The ATN-ISS achieved good discrimination in both the ICU and non-ICU groups, but, regarding calibration, there was a discreet over estimating of mortality in the non-ICU group. The ATN-ISS showed a greater capacity for discrimination than the APACHE II in both the ICU and non-ICU groups. It was concluded that the APACHE II and ATN-ISS scores could be used for stratification of risk in patients with ARF treated outside of the ICU in Brazil.

  15. Apache Kafka

    CERN Document Server

    Garg, Nishant

    2013-01-01

    The book will follow a step-by-step tutorial approach which will show the readers how to use Apache Kafka for messaging from scratch.Apache Kafka is for readers with software development experience, but no prior exposure to Apache Kafka or similar technologies is assumed. This book is also for enterprise application developers and big data enthusiasts who have worked with other publisher-subscriber based systems and now want to explore Apache Kafka as a futuristic scalable solution.

  16. The risk of early mortality of polytrauma patients associated to ISS, NISS, APACHE II values and prothrombin time.

    Science.gov (United States)

    Mica, Ladislav; Rufibach, Kaspar; Keel, Marius; Trentz, Otmar

    2013-01-01

    The early hemodynamic normalization of polytrauma patients may lead to better survival outcomes. The aim of this study was to assess the diagnostic quality of trauma and physiological scores from widely used scoring systems in polytrauma patients. In total, 770 patients with ISS > 16 who were admitted to a trauma center within the first 24 hours after injury were included in this retrospective study. The patients were subdivided into three groups: those who died on the day of admission, those who died within the first three days, and those who survived for longer than three days. ISS, NISS, APACHE II score, and prothrombin time were recorded at admission. The descriptive statistics for early death in polytrauma patients who died on the day of admission, 1-3 days after admission, and > 3 days after admission were: ISS of 41.0, 34.0, and 29.0, respectively; NISS of 50.0, 50.0, and 41.0, respectively; APACHE II score of 30.0, 25.0, and 15.0, respectively; and prothrombin time of 37.0%, 56.0%, and 84%, respectively. These data indicate that prothrombin time (AUC: 0.89) and APACHE II (AUC: 0.88) have the greatest prognostic utility for early death. The estimated densities of the scores may suggest a direction for resuscitative procedures in polytrauma patients. "Retrospektive Analysen in der Chirurgischen Intensivmedizin"StV01-2008.

  17. Jicarilla Apaches.

    Science.gov (United States)

    Van Roekel, Gertrude B.

    Geronimo's surrender in 1886 ended some 200 years' warfare against encroaching white man in that broad area abutting the Rocky Mountains. Thus, the free-roaming period of Apache life, marked by repeated instances of bad faith and broken treaties, was ended and the Jicarilla Apaches were delivered to their reservation in northern New Mexico. The…

  18. APACHE-O评分系统对急性重症胰腺炎的预测价值%The predictive value of combination of APACHE- Ⅱ score and an obesity score (APACHE-O) for severe acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    王飞海; 金洲祥; 徐鲁白; 郑志强

    2007-01-01

    目的 探讨APACHE-O评分系统(APACHE-Ⅱ+肥胖指标评分)对急性重症胰腺炎的预测价值.方法 2004年1月1日至2006年1月1日间急性胰腺炎患者142例,根据体重指数(bodv mass index,BMI)分组,把BMI≥26 kg/m归为肥胖组,BMI<26 kg/m归为非肥胖组.比较两组患者病情严重程度及并发症等发生情况.分别计算入院24 h内APACHE-Ⅱ和APACHE-O评分在不同临界点对急性重症胰腺炎预测的敏感性、特异性、阳性预测值、阴性预测值和准确性,绘制APACHE-Ⅱ和APACHE-O评分受试者工作曲线(receive-operating curves,ROC).通过比较ROC的曲线下面积(area under the curve,AUC)来比较两评分系统的预测准确性.结果 肥胖组中急性重症胰腺炎患者比例显著高于非肥胖组(P<0.05),肥胖组中胰腺坏死、胰腺假性囊肿及肺功能衰竭发生率显著高于非肥胖组(P<0.05).取临界点为8时,APACHE-Ⅱ和APACHE-O评分对急性重症胰腺炎预测的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为78.9%,85.4%,45.5%,96.3%,84.5%和78.9%,82.1%,40.5%,96.2%,81.7%.APACHE-Ⅱ和APACHE-O评分的ROC的AUC分别为0.864和0.870,提示APACHE-O评分对重症胰腺炎预测价值稍高于APACHE-Ⅱ评分.结论 肥胖型急性胰腺炎患者预后更差.与入院时A-PACHE-Ⅱ评分比较,APACHE-O评分对急性重症胰腺炎的预测价值略高于APACHE-Ⅱ,为理想的急性重症胰腺炎预测系统.

  19. Balthazar computed tomography severity index is superior to Ranson criteria and APACHE Ⅱ scoring system in predicting acute pancreatitis outcome

    Institute of Scientific and Technical Information of China (English)

    Ting-Kai Leung; Chi-Ming Lee; Shyr-Yi Lin; Hsin-Chi Chen; Hung-Jung Wang; Li-Kuo Shen; Ya-Yen Chen

    2005-01-01

    AIM: Acute pancreatitis (AP) is a process with variable involvement of regional tissues or organ systems.Multifactorial scales included the Ranson, Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) systems and Balthazar computed tomography severity index (CTSI).The purpose of this review study was to assess the accuracy of CTSI, Ranson score, and APACHE Ⅱ score in course and outcome prediction of AP.METHODS: We reviewed 121 patients who underwent helical CT within 48 h after onset of symptoms of a first episode of AP between 1999 and 2003. Fourteen inappropriate subjects were excluded; we reviewed the 107 contrastenhanced CT images to calculate the CTSI. We also reviewed their Ranson and APACHE Ⅱ score. In addition, complications,duration of hospitalization, mortality rate, and other pathology history also were our comparison parameters.RESULTS: We classified 85 patients (79%) as having mild AP (CTSI <5) and 22 patients (21%) as having severe AP (CTSI ≥5). In mild group, the mean APACHE Ⅱ score and Ranson score was 8.6±1.9 and 2.4±1.2, and those of severe group was 10.2±2.1 and 3.1±0.8, respectively. The most common complication was pseudocyst and abscess and it presented in 21 (20%) patients and their CTSI was 5.9±1.4. A CTSI ≥5 significantly correlated with death,complication present, and prolonged length of stay.Patients with a CTSI ≥5 were 15 times to die than those CTSI <5, and the prolonged length of stay and complications present were 17 times and 8 times than that in CTSI <5,respectively.CONCLUSION: CTSI is a useful tool in assessing the severity and outcome of AP and the CTSI ≥5 is an index in our study. Although Ranson score and APACHE Ⅱ score also are choices to be the predictors for complications,mortality and the length of stay of AP, the sensitivity of them are lower than CTSI.

  20. Utility of Procalcitonin (PCT and Mid regional pro-Adrenomedullin (MR-proADM in risk stratification of critically ill febrile patients in Emergency Department (ED. A comparison with APACHE II score

    Directory of Open Access Journals (Sweden)

    Travaglino Francesco

    2012-08-01

    Full Text Available Abstract Background The aim of our study was to evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization. Methods This was an observational, multicentric study. We enrolled 128 patients referred to the ED with high fever and a suspicion of severe infection such as sepsis, lower respiratory tract infections, urinary tract infections, gastrointestinal infections, soft tissue infections, central nervous system infections, or osteomyelitis. The APACHE II score was calculated for each patient. Results MR-proADM median values in controls were 0.5 nmol/l as compared with 0.85 nmol/l in patients (P P . MR-proADM and PCT levels were significantly increased in accordance with the Apache II quartiles (P  respectively. In the respiratory infections, urinary infections, and sepsis-septic shock groups we found a correlation between the Apache II and MR-proADM respectively and MR-proADM and PCT respectively. We evaluated the ability of MR-proADM and PCT to predict hospitalization in patients admitted to our emergency departments complaining of fever. MR-proADM alone had an AUC of 0.694, while PCT alone had an AUC of 0.763. The combined use of PCT and MR-proADM instead showed an AUC of 0.79. Conclusions The present study highlights the way in which MR-proADM and PCT may be helpful to the febrile patient’s care in the ED. Our data support the prognostic role of MR-proADM and PCT in that setting, as demonstrated by the correlation with the APACHE II score. The combined use of the two biomarkers can predict a subsequent hospitalization of febrile patients. The rational use of these two molecules could lead to several advantages, such as faster diagnosis, more accurate risk stratification, and optimization of the treatment, with consequent benefit to the patient and

  1. Prediction of outcome from intensive care: a prospective cohort study comparing Acute Physiology and Chronic Health Evaluation II and III prognostic systems in a United Kingdom intensive care unit.

    Science.gov (United States)

    Beck, D H; Taylor, B L; Millar, B; Smith, G B

    1997-01-01

    To evaluate the ability of two prognostic systems to predict hospital mortality in adult intensive care patients. Prospective cohort study. A mixed medical and surgical intensive care unit (ICU) in the United Kingdom. A total of 1,144 patients consecutively admitted to the study. None. Acute Physiology and Chronic Health Evaluation (APACHE) II and III prognostic systems were applied to assess probabilities of hospital mortality, which were compared with the actual outcome. The overall goodness-of-fit of both models was assessed. Hospital death rates were higher than those predicted by each system. Risk estimates showed a strong positive correlation between both systems (nonsurvivors r2 = 0.756, p best overall total correct classification rate was 80.6% for APACHE III and 77.9% for APACHE II (both for a decision criterion of 40%). The areas under the receiver operating characteristic curves were 0.806 and 0.847 for APACHE II and III, respectively, confirming the better discrimination of APACHE III. When patients were classified by diagnostic categories, risk predictions did not fit uniformly across the spectrum of disease groups. For both models, mortality ratios were highest for trauma patients and lowest for the group with respiratory disease. APACHE II predictions for patients with gastrointestinal disease were significantly better. Risk estimates for surgical admissions were superior with APACHE II (MR = 1.27) compared with APACHE III (MR = 1.56), but were similar for medical patients (1.22 vs. 1.28 for APACHE II and III, respectively). Bias induced by factors reflecting the clinical practice in an individual ICU (e.g., admission criteria, treatment before admission) may have considerable impact on risk estimates. The identification of such factors appears to be a prerequisite for the meaningful interpretation of observed and predicted death rates on the individual ICU level. Both predictive models demonstrated a similar degree of overall goodness-of-fit. APACHE

  2. Prognostic scales ISS-RTS-TRISS, PRISM, APACHE II and PTS in decision support of treatment children with severe mechanical trauma.

    Science.gov (United States)

    Vasilyeva, I V; Shvirev, S L; Arseniev, S B; Zarubina, T V

    2013-01-01

    The aim of the present study is to assess a possibility and validity of prognostic scales ISS-RTS-TRISS, PRISM, APACHE II and PTS to be used for the automated calculation in decision support when treating children with severe mechanical traumas. The mentioned scales are used in the Hospital Information System (HIS) MEDIALOG. The retrospective study was conducted using clinical and physiological data collected at the admission and during the first 24 hours of hospitalization in 166 patients. Scales PRISM, APACHE II, ISS-RTS-TRISS were used for calculating the severity of injury and for prognosis in death outcomes. Scale PTS was used for evaluating the severity index only. Our research has shown that ISS-RTS-TRISS has excellent discrimination ability, PRISM and APACHE II prognostic scales have acceptable discrimination ability; moreover, they all have significant calibration ability. PTS scale has acceptable discrimination ability. It has been showed that automated calculation scales ISS-RTS-TRISS, PRISM, APACHE II and PTS are useful for assessing outcomes in children with severe mechanical trauma.

  3. Prognostic scoring systems for mortality in intensive care units--the APACHE model.

    Science.gov (United States)

    Niewiński, Grzegorz; Starczewska, Małgorzata; Kański, Andrzej

    2014-01-01

    The APACHE (Acute Physiology and Chronic Health Evaluation) scoring system is time consuming. The mean time for introducing a patient's data to APACHE IV is 37.3 min. Nevertheless, statisticians have known for years that the higher the number of variables the mathematical model describes, the more accurate the model. Because of the necessity of gathering data over a 24-hour period and of determining one cause for ICU admission, the system is troublesome and prone to mistakes. The evolution of the APACHE scoring system is an example of unfulfilled hopes for accurately estimating the risk of death for patients admitted to the ICU; satisfactory prognostic effects resulting from the use of APACHE II and III have been recently studied in patients undergoing liver transplantations. Because no increase in the predictive properties of successive versions has been observed, the search for other solutions continues. The APACHE IV scoring system is helpful; however, its use without prepared spreadsheets is almost impractical. Therefore, although many years have passed since its original publication, APACHE II or its extension APACHE III is currently used in clinical practice.

  4. Apache Maven cookbook

    CERN Document Server

    Bharathan, Raghuram

    2015-01-01

    If you are a Java developer or a manager who has experience with Apache Maven and want to extend your knowledge, then this is the ideal book for you. Apache Maven Cookbook is for those who want to learn how Apache Maven can be used for build automation. It is also meant for those familiar with Apache Maven, but want to understand the finer nuances of Maven and solve specific problems.

  5. APACHE: an evaluation.

    Science.gov (United States)

    Wheeler, Megan M

    2009-01-01

    A cursory evaluation of the Acute Physiology and Chronic Health Evaluation, commonly known as the APACHE scoring system, validates its relevancy as the most widely used method for assessing severity and prognosis in intensive care unit patients. The APACHE system works and the evolution from APACHE I to APACHE IV reveal that each version has its positives and negatives. It would behoove critical care nurses to know differences and how each could be best utilized.

  6. Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure

    Institute of Scientific and Technical Information of China (English)

    Necdet Guler; Omer Unalp; Ayse Guler; Onur Yaprak; Murat Dayangac; Murat Sozbilen; Murat Akyildiz and Yaman Tokat

    2013-01-01

    BACKGROUND: The timing and selection of patients for liver transplantation in acute liver failure are great challenges. This study  aimed  to  investigate  the  effect  of  Glasgow  coma  scale (GCS) and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure. METHOD: A total of 25 patients with acute liver failure were retrospectively  analyzed  according  to  age,  etiology,  time  to transplantation, coma scores, complications and mortality. RESULTS: Eighteen  patients  received  transplants  from  live donors and 7 had cadaveric whole liver transplants. The mean duration  of  follow-up  after  liver  transplantation  was  39.86± 40.23  months.  Seven  patients  died  within  the  perioperative period and the 1-, 3-, 5-year survival rates of the patients were 72%, 72% and 60%, respectively. The parameters evaluated for the perioperative deaths versus alive were as follows: the mean age of the patients was 33.71 vs 28 years, MELD score was 40 vs 32.66, GCS was 5.57 vs 10.16, APACHE-II score was 23 vs 18.11, serum sodium level was 138.57 vs 138.44 mmol/L, mean waiting time before the operation was 12 vs 5.16 days. Low GCS, high APACHE-II score and longer waiting time before the operation (P CONCLUSION: Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation.

  7. Comparison of Predicted Models APACHE IV in Different Groups of Patients in Medical Intensive Care Unit%APACHE Ⅳ评分系统在内科重症监护室不同患者群体使用的比较

    Institute of Scientific and Technical Information of China (English)

    曾勉; 李悦; 卢桂芳

    2011-01-01

    [目的]评估并比较APACHE Ⅳ评分系统在内科重症监护室对于不同群体患者预后的预测效力.[方法]回顾性资料收集2005年3月至2010年12月入住我院内科ICU患者的病历资料450例.计算入院24 h内的APACHE Ⅳ评分及预测死亡率,通过标准化死亡比值(SMR)来评估其对总体患者及不同群体患者死亡率的预测准确性.[结果]本研究共纳入450例患者,死亡率为34.9%.APACHE Ⅳ评分为(61±26)分,预测死亡率为28.03%.APACHE Ⅳ预测的死亡率显著低于实际死亡率(SMR分别为1.24,95% CI 1.13~1.39).对不同疾病、不同死亡风险、不同年龄的患者,APACHE Ⅳ评分系统预测死亡率的准确性均不一致.对呼吸系统患者的死亡率存在低估(SMR=1.44,95%CI 1.34~1.52),尤其是对重症肺炎患者.APACHE Ⅳ低估了低风险及中间组患者的死亡率(SMR=1.57,95%CI 1.45~1.72;SMR=1.40,95%CI 1.34~1.46),而在高风险组预测死亡率准确性高(SMR=1.02,95%CI 0.97~1.08).对年龄<70岁的患者,APACHE Ⅳ也明显低估死亡率(SMR=1.33,95%CI 1.18~1.52),但对于>70岁的患者预测准确(SMR=1.10,95%CI 0.96~1.33).[结论]在内科ICU对APACHE Ⅳ进行验证,其对总体患者的死亡率存在低估,主要是对呼吸系统疾病、低风险组及年龄<70岁等患者的死亡风险呈现低估.%[Objective] To evaluate and compare the prognostic predicted abilities of Acute Physiologic and Chronic Health Evaluation (APACHE) IV system in different groups of medical intensive care unit (MICU) patients. [Methods] Retrospectively collected the medical records of 450 patients admitted to medical intensive care unit of First Affiliated Hospital of Sun Yat-sen University between March 2005 and December 2010. We calculated the APACHE IV scores and mortality probabilities within 24 hours after admission. The predictive accuracy of APACHE IV in total population and different subgroups were tested using standardized

  8. APACHE O评分系统对急性胰腺炎预后的评估价值%APACHE O scoring system in predicting the outcome of acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    金洲祥; 张伟; 倪仲琳; 王飞海

    2010-01-01

    @@ 急性胰腺炎是一种常见的外科急腹症, 病情复杂,预后差,APACHE Ⅱ评分系统是目前一较全面的多因素预后评分系统[1],但仍存在一定局限性.APACHE O评分系统(APACHE Ⅱ评分加肥胖指标评分)是近年提出的一种急性胰腺炎预后评分系统[2],本文旨在通过比较APACHE O评分与APACHE Ⅱ评分对急性重症胰腺炎的判断能力,对急性胰腺炎局部、全身并发症及死亡率的预测价值,旨在明确APACHE O评分系统对急性胰腺炎预后的评估价值.

  9. APACHE-O评分系统对急性重症胰腺炎的预测价值%Predictive value of combination of APACHE-Ⅱ score and an obesity score (APACHE-O) for the prediction of severe acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    杨燕贻; 龙利民; 周建平

    2010-01-01

    目的 探讨APACHE-O评分系统(APACHE-Ⅱ+肥胖指标评分)对急性重症胰腺炎的预测价值.方法 该院2004年1月1日~2006年1月1日收治的急性胰腺炎患者142例,根据体重指数(BMI)分组,BMI≥26 kg/m2归为肥胖组,BMI<26kg/m2归为非肥胖组.比较两组患者病情严重程度及并发症等发生情况.分别计算入院24 h内APACHE-Ⅱ和APACHE-O评分在不同临界点对急性重症胰腺炎预测的敏感性、特异性、阳性预测值、阴性预测值和准确性,绘制APACHE-Ⅱ和APACHE-O评分受试者工作曲线(ROC).通过比较ROC的曲线下面积(AUC)来比较两评分系统的预测准确性.结果 肥胖组中急性重症胰腺炎患者比例显著高于非肥胖组(P<0.05),肥胖组中胰腺坏死、胰腺假性囊肿及肺功能衰竭发生率显著高于非肥胖组(P<0.05).取临界点为8时,APACHE-Ⅱ和APACHE-O评分对急性重症胰腺炎预测的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为78.9%、85.4%、45.5%、96.3%、84.5%和78.9%、82.1%、40.5%、96.2%、81.7%.APACHE-Ⅱ和APACHE-O评分的ROC的曲线下面积(AUC)分别为0.864和0.870,提示APACHE-O评分对重症胰腺炎预测价值稍高于APACHE-Ⅱ评分.结论 肥胖型急性胰腺炎患者预后更差.与入院时APACHE-Ⅱ评分比较,APACHE-O评分对急性重症胰腺炎的预测价值略高于APACHE-Ⅱ,为理想的急性重症胰腺炎预测系统.

  10. Learning Apache Kafka

    CERN Document Server

    Garg, Nishant

    2015-01-01

    This book is for readers who want to know more about Apache Kafka at a hands-on level; the key audience is those with software development experience but no prior exposure to Apache Kafka or similar technologies. It is also useful for enterprise application developers and big data enthusiasts who have worked with other publisher-subscriber-based systems and want to explore Apache Kafka as a futuristic solution.

  11. Apache The Definitive Guide

    CERN Document Server

    Laurie, Ben

    2003-01-01

    Apache is far and away the most widely used web server platform in the world. This versatile server runs more than half of the world's existing web sites. Apache is both free and rock-solid, running more than 21 million web sites ranging from huge e-commerce operations to corporate intranets and smaller hobby sites. With this new third edition of Apache: The Definitive Guide, web administrators new to Apache will come up to speed quickly, and experienced administrators will find the logically organized, concise reference sections indispensable, and system programmers interested in customizin

  12. Learning Apache Karaf

    CERN Document Server

    Edstrom, Johan; Kesler, Heath

    2013-01-01

    The book is a fast-paced guide full of step-by-step instructions covering all aspects of application development using Apache Karaf.Learning Apache Karaf will benefit all Java developers and system administrators who need to develop for and/or operate Karaf's OSGi-based runtime. Basic knowledge of Java is assumed.

  13. Apache Solr beginner's guide

    CERN Document Server

    Serafini, Alfredo

    2013-01-01

    Written in a friendly, example-driven format, the book includes plenty of step-by-step instructions and examples that are designed to help you get started with Apache Solr.This book is an entry level text into the wonderful world of Apache Solr. The book will center around a couple of simple projects such as setting up Solr and all the stuff that comes with customizing the Solr schema and configuration. This book is for developers looking to start using Apache Solr who are stuck or intimidated by the difficulty of setting it up and using it.For anyone wanting to embed a search engine in their

  14. The APACHE Project

    Directory of Open Access Journals (Sweden)

    Giacobbe P.

    2013-04-01

    Full Text Available First, we summarize the four-year long efforts undertaken to build the final setup of the APACHE Project, a photometric transit search for small-size planets orbiting bright, low-mass M dwarfs. Next, we describe the present status of the APACHE survey, officially started in July 2012 at the site of the Astronomical Observatory of the Autonomous Region of the Aosta Valley, in the Western Italian Alps. Finally, we briefly discuss the potentially far-reaching consequences of a multi-technique characterization program of the (potentially planet-bearing APACHE targets.

  15. Instant Apache Wicket 6

    CERN Document Server

    Longo, João Sávio Ceregatti

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This Starter style guide takes the reader through the basic workflow of Apache Wicket in a practical and friendly style.Instant Apache Wicket 6 is for people who want to learn the basics of Apache Wicket 6 and who already have some experience with Java and object-oriented programming. Basic knowledge of web concepts like HTTP and Ajax will be an added advantage.

  16. Apache Solr essentials

    CERN Document Server

    Gazzarini, Andrea

    2015-01-01

    If you are a competent developer with experience of working with technologies similar to Apache Solr and want to develop efficient search applications, then this book is for you. Familiarity with the Java programming language is required.

  17. Apache Mahout essentials

    CERN Document Server

    Withanawasam, Jayani

    2015-01-01

    If you are a Java developer or data scientist, haven't worked with Apache Mahout before, and want to get up to speed on implementing machine learning on big data, then this is the perfect guide for you.

  18. Apache Mahout cookbook

    CERN Document Server

    Giacomelli, Piero

    2013-01-01

    Apache Mahout Cookbook uses over 35 recipes packed with illustrations and real-world examples to help beginners as well as advanced programmers get acquainted with the features of Mahout.""Apache Mahout Cookbook"" is great for developers who want to have a fresh and fast introduction to Mahout coding. No previous knowledge of Mahout is required, and even skilled developers or system administrators will benefit from the various recipes presented

  19. The value of procalcitonin and the SAPS II and APACHE III scores in the differentiation of infectious and non-infectious fever in the ICU: a prospective, cohort study.

    Science.gov (United States)

    Jeon, Eun Ju; Jung, Jae Woo; Choi, Jae Chol; Shin, Jong Wook; Park, In Won; Choi, Byoung Whui; Park, Ae Ja; Kim, Jae Yeol

    2010-11-01

    Early and accurate differentiation between infectious and non-infectious fever is vitally important in the intensive care unit (ICU). In the present study, patients admitted to the medical ICU were screened daily from August 2008 to February 2009. Within 24 hr after the development of fever (>38.3℃), serum was collected for the measurement of the procalcitonin (PCT) and high mobility group B 1 levels. Simplified Acute Physiology Score (SAPS) II and Acute Physiology And Chronic Health Evaluation (APACHE) III scores were also analyzed. Sixty-three patients developed fever among 448 consecutive patients (14.1%). Fever was caused by either infectious (84.1%) or non-infectious processes (15.9%). Patients with fever due to infectious causes showed higher values of serum PCT (7.8±10.2 vs 0.5±0.2 ng/mL, P=0.026), SAPS II (12.0±3.8 vs 7.6±2.7, P=0.006), and APACHE III (48±20 vs 28.7±13.3, P=0.039) than those with non-infectious fever. In receiver operating characteristic curve analysis, the area under the curve was 0.726 (95% CI; 0.587-0.865) for PCT, 0.759 (95% CI; 0.597-0.922) for SAPS II, and 0.715 (95% CI; 0.550-0.880) for APACHE III. Serum PCT, SAPS II, and APACHE III are useful in the differentiation between infectious and non-infectious fever in the ICU.

  20. 脂肪肝诊断联合APACHE-Ⅱ评分提高预测重症急性胰腺炎的能力%A combination of hepatic steatosis with APACHE-Ⅱ score improves the ability of predicting severe acute pancreatitis

    Institute of Scientific and Technical Information of China (English)

    郝一鸣; 王士琪; 冯全新; 冯向英; 余鹏飞; 白槟; 邱兆岩; 王谦; 赵青川

    2016-01-01

    目的 明确脂肪肝是否为重症急性胰腺炎的暴露因素,判断脂肪肝诊断联合急性生理学和慢性健康评估(acute physiology and chronic health evaluation,APACHE-Ⅱ)评分预测重症急性胰腺炎的能力.方法 回顾性分析148例急性胰腺炎患者的临床资料,分为重症急性胰腺炎组(41例)和轻症急性胰腺炎组(107例).比较两组患者的一般资料.根据APACHE-Ⅱ评分,进行亚组分析.计算联合预测的敏感性、特异性和ROC曲线下面积.结果 脂肪肝与重症急性胰腺炎呈正相关.合并脂肪肝的患者发生重症急性胰腺炎的概率是未合并脂肪肝的5.33倍(OR =5.33,P=0.003).亚组分析结果表明,入院24 h内APACHE-Ⅱ评分<8分的患者,合并脂肪肝的患者较未合并脂肪肝的患者,重症胰腺炎发生率((34.5%比6.9%,P<0.001)、全身并发症发生率更高(31%比5.7%,P<0.001).入院24 h内APACHE-Ⅱ评分≥8分的患者,合并脂肪肝的患者较未合并脂肪肝的患者,重症胰腺炎发生率(100%比65%,P=0.029)、全身并发症发生率更高(100%比65%,P=0.029).入院24 h内APACHE-Ⅱ评分预测重症急性胰腺炎的敏感性、特异性、ROC曲线下面积分别为61.0% 、93.5%、0.772.脂肪肝预测重症急性胰腺炎的敏感性、特异性、ROC曲线下面积分别为53.7% 、82.2%、0.680.两个指标联合预测重症急性胰腺炎的敏感性、特异性、ROC曲线下面积分别为85.4% 、75.7%、0.861.结论 脂肪肝和重症急性胰腺炎具有相关性.脂肪肝诊断联合APACHE-Ⅱ评分可以提高预测重症急性胰腺炎的能力.%Objective To identify whether hepatic steatosis is the exposure factor of severe acute pancreatitis (SAP) and to investigate the prognostic efficacy of combining hepatic steatosis with APACHE-Ⅱ score in predicting the severity of SAP.Methods Clinicopathological data of 148 patient diagnosed as acute pancreatitis in Xijing Hospital from April 2011 to

  1. The use of perioperative serial blood lactate levels, the APACHE II and the postoperative MELD as predictors of early mortality after liver transplantation O uso da dosagem seriada do lactato sérico no perioperatório, do APACHE II e do MELD pós-operatório como preditores de mortalidade precoce após transplante hepático

    Directory of Open Access Journals (Sweden)

    Anibal Basile-Filho

    2011-12-01

    Full Text Available PURPOSE: To evaluate the accuracy of different parameters in predicting early (one-month mortality of patients submitted to orthotopic liver transplantation (OLT. METHODS: This is a retrospective study of forty-four patients (38 males and 10 females, mean age of 52.2 ± 8.9 years admitted to the Intensive Care Unit of a tertiary hospital. Serial lactate blood levels, APACHE II, MELD post-OLT, creatinine, bilirubin and INR parameters were analyzed by receiver-operator characteristic (ROC curves as evidenced by the area under the curve (AUC. The level of significance was set at 0.05. RESULTS: The mortality of OLT patients within one month was 17.3%. Differences in blood lactate levels became statistically significant between survivors and nonsurvivors at the end of the surgery (pOBJETIVO: Avaliar qual parâmetro é o mais eficiente na predição de mortalidade precoce (um mês de pacientes submetidos a transplante ortotópico de fígado (OLT. MÉTODOS: Estudo retrospectivo em cinqüenta e oito pacientes adultos (44 homens e 14 mulheres, com uma idade média de 51,7 ± 10,1 anos admitidos na Unidade de Terapia Intensiva de um hospital terciário. Os parâmetros como a dosagem seriada de lactato no sangue, APACHE II, MELD pós-OLT, creatinina, bilirrubina e INR foram analisados por curvas ROC (Receiver-operator characteristic, evidenciado pela área abaixo da curva (AUC. O nível de significância foi definido em 0,05. RESULTADOS: A mortalidade dos pacientes OLT em até um mês foi de 17,3%. As diferenças no nível de lactato no sangue tornaram-se estatisticamente significantes entre sobreviventes e não sobreviventes no final da cirurgia (p < 0,05. A AUC foi de 0,726 (95%CI = 0,593-0,835 para APACHE II (p = 0,02; 0,770 (95%CI = 0,596-0,849 para o lactato sérico (L7-L8 (p = 0,03; 0,814 (95%CI = 0,690-0,904 para MELD post-OLT (p < 0,01; 0,550 (95%CI = 0,414-0,651 de creatinina (p = 0,64; 0,705 (95%CI = 0,571-0,818 de bilirrubina (p = 0,05 e 0

  2. The impact of delirium on the prediction of in-hospital mortality in intensive care patients.

    NARCIS (Netherlands)

    Boogaard, M.H.W.A. van den; Peters, S.A.; Hoeven, J.G. van der; Dagnelie, P.C.; Leffers, P.; Pickkers, P.; Schoonhoven, L.J.

    2010-01-01

    INTRODUCTION: Predictive models, such as acute physiology and chronic health evaluation II (APACHE-II), are widely used in intensive care units (ICUs) to estimate mortality. Although the presence of delirium is associated with a higher mortality in ICU patients, delirium is not part of the APACHE-II

  3. Apache Tomcat 7 Essentials

    CERN Document Server

    Khare, Tanuj

    2012-01-01

    This book is a step-by-step tutorial for anyone wanting to learn Apache Tomcat 7 from scratch. There are plenty of illustrations and examples to escalate you from a novice to an expert with minimal strain. If you are a J2EE administrator, migration administrator, technical architect, or a project manager for a web hosting domain, and are interested in Apache Tomcat 7, then this book is for you. If you are someone responsible for installation, configuration, and management of Tomcat 7, then too, this book will be of help to you.

  4. Instant Apache Maven starter

    CERN Document Server

    Turatti, Maurizio

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks.The book follows a starter approach for using Maven to create and build a new Java application or Web project from scratch.Instant Apache Maven Starter is great for Java developers new to Apache Maven, but also for experts looking for immediate information. Moreover, only 20% of the necessary information about Maven is used in 80% of the activities. This book aims to focus on the most important information, those pragmatic parts you actually use

  5. Instant Apache Stanbol

    CERN Document Server

    Bachmann-Gmür, Reto

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Instant Apache Stanbol How-to will enable you to become an expert in content management with semantics at the core, with the help of practical recipes. Instant Apache Stanbol How-to is for Java developers who would like to extend Stanbol or would just like to use Stanbol without caring about its internals. A few recipes that show how to extend Stanbol require some familiarity with Java and JavaScript.

  6. Apache, Vol. I.

    Science.gov (United States)

    Bodiroga, Ronald, Comp.; And Others

    The short stories, poems, and cultural descriptions about American Indians (volume 1 of two) are the result of a combined effort of the 7th grade students of Rice School District (Sacaton, Arizona), their teacher, and the parents and friends of the students of the San Carlos Apache Indian Reservation (Arizona). The 24 student contributors prepared…

  7. SAN CARLOS APACHE PAPERS.

    Science.gov (United States)

    ROESSEL, ROBERT A., JR.

    THE FIRST SECTION OF THIS BOOK COVERS THE HISTORICAL AND CULTURAL BACKGROUND OF THE SAN CARLOS APACHE INDIANS, AS WELL AS AN HISTORICAL SKETCH OF THE DEVELOPMENT OF THEIR FORMAL EDUCATIONAL SYSTEM. THE SECOND SECTION IS DEVOTED TO THE PROBLEMS OF TEACHERS OF THE INDIAN CHILDREN IN GLOBE AND SAN CARLOS, ARIZONA. IT IS DIVIDED INTO THREE PARTS--(1)…

  8. Mastering Apache Cassandra

    CERN Document Server

    Neeraj, Nishant

    2013-01-01

    Mastering Apache Cassandra is a practical, hands-on guide with step-by-step instructions. The smooth and easy tutorial approach focuses on showing people how to utilize Cassandra to its full potential.This book is aimed at intermediate Cassandra users. It is best suited for startups where developers have to wear multiple hats: programmer, DevOps, release manager, convincing clients, and handling failures. No prior knowledge of Cassandra is required.

  9. Apache 2 Pocket Reference For Apache Programmers & Administrators

    CERN Document Server

    Ford, Andrew

    2008-01-01

    Even if you know the Apache web server inside and out, you still need an occasional on-the-job reminder -- especially if you're moving to the newer Apache 2.x. Apache 2 Pocket Reference gives you exactly what you need to get the job done without forcing you to plow through a cumbersome, doorstop-sized reference. This Book provides essential information to help you configure and maintain the server quickly, with brief explanations that get directly to the point. It covers Apache 2.x, giving web masters, web administrators, and programmers a quick and easy reference solution. This pocket r

  10. Instant Apache Sqoop

    CERN Document Server

    Jain, Ankit

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Instant Apache Sqoop is full of step-by-step instructions and practical examples along with challenges to test and improve your knowledge.This book is great for developers who are looking to get a good grounding in how to effectively and efficiently move data between RDBMS and the Hadoop ecosystem. It's assumed that you will have some experience in Hadoop already as well as some familiarity with HBase and Hive.

  11. Apache Cordova 3 programming

    CERN Document Server

    Wargo, John M

    2013-01-01

    Written for experienced mobile developers, Apache Cordova 3 Programming is a complete introduction to Apache Cordova 3 and Adobe PhoneGap 3. It describes what makes Cordova important and shows how to install and use the tools, the new Cordova CLI, the native SDKs, and more. If you’re brand new to Cordova, this book will be just what you need to get started. If you’re familiar with an older version of Cordova, this book will show you in detail how to use all of the new stuff that’s in Cordova 3 plus stuff that has been around for a while (like the Cordova core APIs). After walking you through the process of downloading and setting up the framework, mobile expert John M. Wargo shows you how to install and use the command line tools to manage the Cordova application lifecycle and how to set up and use development environments for several of the more popular Cordova supported mobile device platforms. Of special interest to new developers are the chapters on the anatomy of a Cordova application, as well ...

  12. Yahoo赞助Apache

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    近日,Yahoo宣布成为Apache基金会(ASF)的白金赞助商。Yahoo表示他们的资金赞助是非盈利性质的,向ASF提供必要的营业资金和硬件基础设施,为ASF的一些项目产业化提供资源。在公司的B10g上,Yahoo特别表达了对ApacheLucene和Hadoop两个项目的兴趣,并且已经雇用了这两个项目的创始人兼Apache副总裁Doug Cutting。

  13. Fluid balance and chloride load in the first 24h of ICU admission and its relation with renal replacement therapies through a multicentre, retrospective, case-control study paired by APACHE-II.

    Science.gov (United States)

    González-Castro, A; Ortiz-Lasa, M; Leizaola, O; Salgado, E; Irriguible, T; Sánchez-Satorra, M; Lomas-Fernández, C; Barral-Segade, P; Cordero-Vallejo, M; Rodrigo-Calabia, E; Dierssen-Sotos, T

    2017-05-01

    To analyse the association between water balance during the first 24h of admission to ICU and the variables related to chloride levels (chloride loading, type of fluid administered, hyperchloraemia), with the development of acute kidney injury renal replacement therapy (AKI-RRT) during patients' admission to ICU. Multicentre case-control study. Hospital-based, national, carried out in 6 ICUs. Cases were patients older than 18 years who developed an AKI-RRT. Controls were patients older than 18 years admitted to the same institutions during the study period, who did not develop AKI-RRT during ICU admission. Pairing was done by APACHE-II. An analysis of unconditional logistic regression adjusted for age, sex, APACHE-II and water balance (in evaluating the type of fluid). We analysed the variables of 430 patients: 215 cases and 215 controls. An increase of 10% of the possibility of developing AKI-RRT per 500ml of positive water balance was evident (OR: 1.09 [95% CI: 1.05 to 1.14]; P<.001). The study of mean values of chloride load administered did not show differences between the group of cases and controls (299.35±254.91 vs. 301.67±234.63; P=.92). The water balance in the first 24h of ICU admission relates to the development of IRA-TRR, regardless of chloraemia. Copyright © 2017 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. MHC Class II epitope predictive algorithms

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lund, Ole; Buus, S

    2010-01-01

    in the predictions. All attempts to make ab initio predictions based on protein structure have failed to reach predictive performances similar to those that can be obtained by data-driven methods. Thousands of different MHC-II alleles exist in humans. Recently developed pan-specific methods have been able to make...

  15. Apache Flink: Distributed Stream Data Processing

    CERN Document Server

    Jacobs, Kevin; CERN. Geneva. IT Department

    2016-01-01

    The amount of data is growing significantly over the past few years. Therefore, the need for distributed data processing frameworks is growing. Currently, there are two well-known data processing frameworks with an API for data batches and an API for data streams which are named Apache Flink and Apache Spark. Both Apache Spark and Apache Flink are improving upon the MapReduce implementation of the Apache Hadoop framework. MapReduce is the first programming model for distributed processing on large scale that is available in Apache Hadoop. This report compares the Stream API and the Batch API for both frameworks.

  16. Curriculum Program for the Apache Language.

    Science.gov (United States)

    Whiteriver Public Schools, AZ.

    These curriculum materials from the Whiteriver (Arizona) Elementary School consist of--(1) an English-Apache word list of some of the most commonly used words in Apache, 29p.; (2) a list of enclitics with approximate or suggested meanings and illustrations of usage, 5 p.; (3) an illustrated chart of Apache vowels and consonants, various written…

  17. Apache ZooKeeper essentials

    CERN Document Server

    Haloi, Saurav

    2015-01-01

    Whether you are a novice to ZooKeeper or already have some experience, you will be able to master the concepts of ZooKeeper and its usage with ease. This book assumes you to have some prior knowledge of distributed systems and high-level programming knowledge of C, Java, or Python, but no experience with Apache ZooKeeper is required.

  18. APACHE score, Severity Index of Paraquat Poisoning, and serum lactic acid concentration in the prognosis of paraquat poisoning of Chinese Patients.

    Science.gov (United States)

    Xu, Shuyun; Hu, Hai; Jiang, Zhen; Tang, Shiyuan; Zhou, Yuangao; Sheng, Jie; Chen, Jinggang; Cao, Yu

    2015-02-01

    Many prognostic indictors have been studied to evaluate the prognosis of paraquat poisoning. However, the optimal indicator remains unclear. To determine the value of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score, the Severity Index of Paraquat Poisoning (SIPP), and serum lactate levels in the prognosis of paraquat poisoning, we performed a prospective study that enrolled 143 paraquat patients. Data were collected from patients (161) at West China Hospital in Chengdu, China, including details about the patients' general conditions, laboratory examinations, and treatment. Receiver operating characteristic curves for predicting inpatient mortality based on APACHE II score, SIPP, and lactate levels were generated. To analyze the best cutoff values for lactate levels, APACHE II scores, and SIPP in predicting the prognosis of paraquat poisoning, the initial parameters on admission and 7-day survival curves of patients with lactate levels greater than or equal to 2.95 mmol/L, APACHE II score greater than or equal to 15.22, and SIPP greater than or equal to 5.50 h · mg/L at the time of arrival at West China Hospital were compared using the 1-way analysis of variance and the log-rank test. The APACHE II score (5.45 [3.67] vs 11.29 [4.31]), SIPP (2.78 [1.89] vs 7.63 [2.46] h · mg/L), and lactate level (2.78 [1.89] vs 7.63 [2.46] mmol/L) were significantly lower in survivors (77) after oral ingestion of paraquat, compared with nonsurvivors (66). The APACHE II score, SIPP, and lactate level had different areas under the curve (0.847, 0.789, and 0.916, respectively) and accuracy (0.64, 0.84, and 0.89, respectively). Respiratory rate, serum creatinine level, Paco2, and mortality rate at 7 days after admission in patients with lactate levels greater than or equal to 2.95 mmol/L were markedly different compared with those of other patients (P paraquat poisoning.

  19. Apache Wars: A Constabulary Perspective

    Science.gov (United States)

    2007-11-02

    to create an acceptable level of violence. The Second Apache Insurgency: Mexico In September 1810, Padre Miguel Hidalgo called for Mexican...just as it did in Southwest America after the Treaty of Hidalgo ended the war with Mexico. These occupations are similar in that the US Army sought... Hidalgo ending the war in 1848, it gained the better part of nine current states, land that also came with many Indian tribes. One associated group of

  20. Mexico and apachería

    Directory of Open Access Journals (Sweden)

    Francisco Julián Durazo Herrmann

    2001-01-01

    Full Text Available The purpose of this document is to analyze the relations between the government of Mexico and the Apaches, one of the nomadic tribes inhabiting Northern Mexico, with the tools and from the perspective of foreign policy. My hypothesis is that, although Mexico´s policy towards the Apaches was never international neither in its object (as the Apaches were never treated as an independent nation nor in its approach (Apache policy in Mexico was designed and implemented mainly by local and state authorities, its object was clearly, albeit indirectly, international: the consolidation of Mexican control over its border with the United States.

  1. Dynamic Apache with Ajax and JSON

    CERN Document Server

    Brown, Tracy

    2006-01-01

    Want to make your Ajax apps more dynamic? This Short Cut shows you how. It covers: Using the Apache 2.2.x framework to build MVC applications incorporating design patternsBuilding custom Apache modules that handle Ajax requests using JSONSolving the page refresh problem in Ajax apps by tracking persistent sessions and using that information to reset the user interface when appropriate We walk you through, in detail and with complete code listings, how to develop the necessary Apache 2.2.x modules. And we conclude with a comprehensive set of appendixes that cover the entire Apache development

  2. Instant Apache Camel messaging system

    CERN Document Server

    Sharapov, Evgeniy

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. A beginner's guide to Apache Camel that walks you through basic operations like installation and setup right through to developing simple applications.This book is a good starting point for Java developers who have to work on an application dealing with various systems and interfaces but who haven't yet started using Enterprise System Buses or Java Business Integration frameworks.

  3. Learning Apache Solr high performance

    CERN Document Server

    Mohan, Surendra

    2014-01-01

    This book is an easy-to-follow guide, full of hands-on, real-world examples. Each topic is explained and demonstrated in a specific and user-friendly flow, from search optimization using Solr to Deployment of Zookeeper applications. This book is ideal for Apache Solr developers and want to learn different techniques to optimize Solr performance with utmost efficiency, along with effectively troubleshooting the problems that usually occur while trying to boost performance. Familiarity with search servers and database querying is expected.

  4. Apache Flume distributed log collection for Hadoop

    CERN Document Server

    D'Souza, Subas

    2013-01-01

    A starter guide that covers Apache Flume in detail.Apache Flume: Distributed Log Collection for Hadoop is intended for people who are responsible for moving datasets into Hadoop in a timely and reliable manner like software engineers, database administrators, and data warehouse administrators

  5. What's New in Apache Web Server 22?

    CERN Document Server

    Bowen, Rich

    2007-01-01

    What's New in Apache Web Server 2.2? shows you all the new features you'll know to set up and administer the Apache 2.2 web server. Learn how to take advantage of its improved caching, proxying, authentication, and other improvements in your Web 2.0 applications.

  6. Random Decision Forests on Apache Spark

    CERN Document Server

    CERN. Geneva

    2016-01-01

    About the speaker Tom White has been an Apache Hadoop committer since February 2007, and is a member of the Apache Software Foundation. He works for Cloudera, a company set up to offer Hadoop support and training. Previously he was as an independent Hadoop consultant, work...

  7. The value of APACHE Ⅱ scoring system in assessment of seyerity and prognosis of patients with organophosphate insecticide poisoning%APACHE Ⅱ评分对有机磷中毒患者病情评估的意义

    Institute of Scientific and Technical Information of China (English)

    胡念丹; 黄敏; 李文强

    2011-01-01

    Objective:To evaluate the severity and the prognosis of the organophosphate insecticide poisoning by using APACHE Ⅱ scoring system. Method: Fifty-one patients with organophosphate insecticide poisoning admitted in our hospital were studied retrospectively. Data associated with APACHE Ⅱ scoring system were recorded and analyzed statistically.Result:The APACHE Ⅱ score of the 51 patients enrolled in our study were ranged from 3 to 28. The APACHE Ⅱ score was (21.43 ± 5.41)in the 7 deaths and (8. 75 ± 3.29 )in the 44 survivors. There was significant differences between the two groups(P<0.01). Conclusion:APACHE Ⅱ scoring system may have some value in predict the prognosis of organophosphate insecticide poisoning.%目的:探讨应用急性生理和慢性健康状况(APACHE Ⅱ)评分评估有机磷农药中毒患者的病情严重程度及预后的意义.方法:回顾性分析我院有机磷农药中毒患者51例,记录与APACHE Ⅱ评分系统相关的数据,并对患者的APACHE Ⅱ评分进行统计学分析.结果:51例患者APACHE Ⅱ评分3~28分.7例死亡患者APACHE Ⅱ评分(21.43±5.41)分,44例存活患者APACHE Ⅱ评分(8.75±3.29)分,两组之间差异有统计学意义(P<0.01).结论:APACHE Ⅱ评分对中毒的预后预测可能有一定的作用.

  8. Research on APACHE Ⅱ scores predicting delirium incidence of patients receiving invasive mechanical ventilation in ICU%APACHEⅡ评分预测ICU有创机械通气患者谵妄的应用研究

    Institute of Scientific and Technical Information of China (English)

    刘春峰; 姚炳荣; 徐爱明; 徐朝晖; 施红伟

    2015-01-01

    Objective To study the correlation between APACHEⅡscores and the probability of patients who are receving invasive mechanical ventilation suffering delirium and the value of predicting delirium. Methods Chose patients receiving invasive mechanical ventilation from January 2011 to January 2014 in ICU for the study and collected APACHE Ⅱ scores of each patient within the first 24 hours. Using Consciousness Assessment Method-ICU (CAM-ICU) to diagnose delirium, divided patients into delirium group and non-delirium group, analyzed and compared APACHEⅡscores of this two groups with statistical methods when difference(P<0.05) was statistically significant. Plot APACHE Ⅱ scores characteristic curve (ROC curve), calculated the area under this ROC curve and carried out predictive value of delirium occurring. Results 50 patients were divided into two groups: delirium group, 28 cases;non-delirium group, 22 cases, the incidence of delirium was 56.0%. APACHEⅡscores of delirium group (29.0±5.6) points, were higher than that of non-delirium group (19.5±4.1) points and the difference was statistically significance (P<0.05). The area under ROC curve of APACHEⅡ scores was 0.920, and then we can determine that the best breaking point of delirium occuring was≥21 points with 100%sensitivity, 68.2%specificity, 80.0%positive predictive value and 100.0%negative predictive value. Conclusion APACHEⅡscores are risk factors of patients who are receving mechanical ventilation suffering delirium. And APACHE Ⅱ scores have high predictive value for those patients. The method of prediction is simple, practical and operational.%目的:探讨APACHEⅡ评分结果与有创机械通气患者发生谵妄的相关性及预测发生谵妄的价值。方法选择2011年1月至2014年1月在我科接受有创机械通气患者为研究对象,采集每位患者入科最初24 h内APACHEⅡ评分结果;采用ICU谵妄诊断的意识状态评估法(CAM-ICU)进行谵妄评估,将

  9. Admission cell free DNA levels predict 28-day mortality in patients with severe sepsis in intensive care.

    Directory of Open Access Journals (Sweden)

    Avital Avriel

    Full Text Available The aim of the current study is to assess the mortality prediction accuracy of circulating cell-free DNA (CFD level at admission measured by a new simplified method.CFD levels were measured by a direct fluorescence assay in severe sepsis patients on intensive care unit (ICU admission. In-hospital and/or twenty eight day all-cause mortality was the primary outcome.Out of 108 patients with median APACHE II of 20, 32.4% have died in hospital/or at 28-day. CFD levels were higher in decedents: median 3469.0 vs. 1659 ng/ml, p<0.001. In multivariable model APACHE II score and CFD (quartiles were significantly associated with the mortality: odds ratio of 1.05, p = 0.049 and 2.57, p<0.001 per quartile respectively. C-statistics for the models was 0.79 for CFD and 0.68 for APACHE II. Integrated discrimination improvement (IDI analyses showed that CFD and CFD+APACHE II score models had better discriminatory ability than APACHE II score alone.CFD level assessed by a new, simple fluorometric-assay is an accurate predictor of acute mortality among ICU patients with severe sepsis. Comparison of CFD to APACHE II score and Procalcitonin (PCT, suggests that CFD has the potential to improve clinical decision making.

  10. Acute physiology, age, and chronic health evaluation (APACHE) III score is an alternative efficient predictor of mortality in burn patients.

    Science.gov (United States)

    Tanaka, Yohei; Shimizu, Mikio; Hirabayashi, Hidemitsu

    2007-05-01

    The present study was performed to evaluate the prognostic value of the acute physiology, age, chronic health evaluation (APACHE) III score in burn patients. We hypothesised that APACHE III score efficiently predicts mortality of burn patients as it reflects the physiological changes in the acute phase and the severity of the underlying illness. Data such as age, gender, inhalation injury, total burn surface area (TBSA), burn index (BI), prognostic burn index (PBI), APACHE III score and outcome of 105 hospitalised patients were analysed retrospectively. TBSA, BI, PBI, and APACHE III score in the mortality group were significantly higher than those of surviving group. The mean scores of surviving versus mortality groups were as follows: TBSA, 19.2+/-17.8% versus 69.1+/-28.4%, pAPACHE III score, 28.4+/-22.2% versus 71.3+/-32.1%, pAPACHE III score showed marked associations between higher scores and higher mortality. APACHE III score showed a significant correlation with PBI (pAPACHE III score could be used as an alternative efficient predictor of mortality in burn patients.

  11. Structural Properties of MHC Class II Ligands, Implications for the Prediction of MHC Class II Epitopes

    DEFF Research Database (Denmark)

    Jørgensen, Kasper Winther; Buus, Søren; Nielsen, Morten

    2010-01-01

    properties of MHC class II ligands. Here, we perform one such large-scale analysis. A large set of SYFPEITHI MHC class II ligands covering more than 20 different HLA-DR molecules was analyzed in terms of their secondary structure and surface exposure characteristics in the context of the native structure......Major Histocompatibility class II (MHC-II) molecules sample peptides from the extracellular space allowing the immune system to detect the presence of foreign microbes from this compartment. Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule...... of the corresponding source protein. We demonstrated that MHC class II ligands are significantly more exposed and have significantly more coil content than other peptides in the same protein with similar predicted binding affinity. We next exploited this observation to derive an improved prediction method for MHC...

  12. Secure Applications Integration with Apache Camel

    Directory of Open Access Journals (Sweden)

    Sorin Popa

    2015-03-01

    Full Text Available Often, applications from a company need to collaborate by exchanging information with each other to support existing business processes. In this paper I present basic concepts about integration applications with Apache Camel and make a demonstration of encrypting messages with Camel components.

  13. Apache Flume distributed log collection for Hadoop

    CERN Document Server

    Hoffman, Steve

    2015-01-01

    If you are a Hadoop programmer who wants to learn about Flume to be able to move datasets into Hadoop in a timely and replicable manner, then this book is ideal for you. No prior knowledge about Apache Flume is necessary, but a basic knowledge of Hadoop and the Hadoop File System (HDFS) is assumed.

  14. Compressor Part II: Volute Flow Predictions

    Directory of Open Access Journals (Sweden)

    Yu-Tai Lee

    1999-01-01

    Full Text Available A numerical method that solves the Reynolds-averaged Navier-Stokes equations is used to study an inefficient component of a shipboard air-conditioning HCFC-124 compressor system. This high-loss component of the centrifugal compressor was identified as the volute through a series of measurements given in Part I of the paper. The predictions were made using three grid topologies. The first grid closes the connection between the cutwater and the discharge diffuser. The other two grids connect the cutwater area with the discharge diffuser. Experiments were performed to simulate both the cutwater conditions used in the predictions. Surface pressures along the outer wall and near the inlet of the volute were surveyed for comparisons with the predictions. Good agreements between the predicted results and the measurements validate the calculations. Total pressure distributions and flow stream traces from the prediction results support the loss distribution through the volute. A modified volute configuration is examined numerically for further loss comparison.

  15. Apache 2.x完整新应用

    Institute of Scientific and Technical Information of China (English)

    马路遥

    2003-01-01

    Apache 1.3相比,Apache 2有许多重要的改进。Apache 2支持多线程和多进程;可以更好地支持诸如BeOS、OS2和Windows等非Unix操作系统,支持下一代互联网协议IPV6;Apache 2的配置文件也比Apache 1.3更容易管理.安装也更为容易。在对Apache 2的应用中,尤其是在Apache+SSL+PHP+Tomcat方面的应用.经常容易遇

  16. Lateral interception II : Predicting hand movements

    NARCIS (Netherlands)

    Michaels, CF; Jacobs, DM; Bongers, RM

    2006-01-01

    D. M. Jacobs and C. F. Michaels (2006) concluded that aspects of hand movements in lateral catching were predicted by the ratio of lateral optical velocity to expansion velocity. Their conclusions were based partly on a modified version of the required velocity model of catching (C. E. Peper, R. J.

  17. Optimizing CMS build infrastructure via Apache Mesos

    CERN Document Server

    Abduracmanov, David; Elmer, Peter; Eulisse, Giulio; Mendez, David; Muzaffar, Shahzad

    2015-01-01

    The Offline Software of the CMS Experiment at the Large Hadron Collider (LHC) at CERN consists of 6M lines of in-house code, developed over a decade by nearly 1000 physicists, as well as a comparable amount of general use open-source code. A critical ingredient to the success of the construction and early operation of the WLCG was the convergence, around the year 2000, on the use of a homogeneous environment of commodity x86-64 processors and Linux. Apache Mesos is a cluster manager that provides efficient resource isolation and sharing across distributed applications, or frameworks. It can run Hadoop, Jenkins, Spark, Aurora, and other applications on a dynamically shared pool of nodes. We present how we migrated our continuos integration system to schedule jobs on a relatively small Apache Mesos enabled cluster and how this resulted in better resource usage, higher peak performance and lower latency thanks to the dynamic scheduling capabilities of Mesos.

  18. Optimizing CMS build infrastructure via Apache Mesos

    Science.gov (United States)

    Abdurachmanov, David; Degano, Alessandro; Elmer, Peter; Eulisse, Giulio; Mendez, David; Muzaffar, Shahzad

    2015-12-01

    The Offline Software of the CMS Experiment at the Large Hadron Collider (LHC) at CERN consists of 6M lines of in-house code, developed over a decade by nearly 1000 physicists, as well as a comparable amount of general use open-source code. A critical ingredient to the success of the construction and early operation of the WLCG was the convergence, around the year 2000, on the use of a homogeneous environment of commodity x86-64 processors and Linux. Apache Mesos is a cluster manager that provides efficient resource isolation and sharing across distributed applications, or frameworks. It can run Hadoop, Jenkins, Spark, Aurora, and other applications on a dynamically shared pool of nodes. We present how we migrated our continuous integration system to schedule jobs on a relatively small Apache Mesos enabled cluster and how this resulted in better resource usage, higher peak performance and lower latency thanks to the dynamic scheduling capabilities of Mesos.

  19. Implementasi Teleconference pada Moodle dengan Apache Openmeetings

    Directory of Open Access Journals (Sweden)

    I Made Warsa Kumara

    2014-06-01

    Full Text Available Berbagai terobosan dalam teknologi internet melahirkan berbagai fasilitas baru dalam dunia pendidikan. Teleconfrence adalah salah satunya yang mampu memperkaya fitur e-learning yang terus berkembang baik fungsi maupun kemampuannya. Dari sekian banyak aplikasi teleconference berbasis web yang tersedia gratis, dipilih Apace OpenMeetings karena memiliki fitur dan dokumentasi yang memadai dan cukup mudah untuk diinstal. Tulisan ini membahas bagaimana implementasi teleconference pada Moodle dengan aplikasi open source Apache OpenMeetings. Penelitian dilakukan dengan studi literatur pada sejumlah artikel dan tulisan yang berkaitan dengan Moodle, teleconference dan Apache OpenMeetings. Pengujian dilakukan pada server elearning Fakultas Kedokteran Universitas Warmadewa, dengan mencoba melakukan conference pada sebuah topik dalam elearning. Server elearning yang digunakan memiliki spesifikasi processor core 2 duo 2,8 GHz dengan Ram 1 GB dan jaringan kabel dengan kecepatan 100 Mbps.

  20. Wisdom Sits in Places: Landscape and Language among the Western Apache.

    Science.gov (United States)

    Basso, Keith H.

    This book of essays draws on a cultural geography project in which an ethnographer and Apache consultants mapped the area around Cibecue, on the Fort Apache Reservation (Arizona). The essays focus on different Apache individuals and examine the ways that Apache constructions of place reach deeply into other cultural spheres. Many Apache place…

  1. Grades 1-8, Apache Junction Unified School District 43, Apache Junction, Arizona. PLATO Evaluation Series.

    Science.gov (United States)

    Quinn, David W.; Quinn, Nancy W.

    Apache Junction Unified School District, Arizona, has embarked on a 5-year program of instructional improvement using technology. PLATO Elementary reading and mathematics products were installed in the district's elementary and middle schools at the beginning of the 1999-2000 school year. This evaluation studied the use and preliminary student…

  2. Performance of APACHE III over time in Australia and New Zealand: a retrospective cohort study.

    Science.gov (United States)

    Paul, E; Bailey, M; Van Lint, A; Pilcher, V

    2012-11-01

    The Acute Physiology and Chronic Health Evaluation (APACHE) III-j model has been used for benchmarking intensive care unit (ICU) outcomes in Australia and New Zealand for over a decade. This study assessed performance of the APACHE III-j model in adult patients admitted to Australasian ICUs during a ten-year period. Data were extracted from the Australian and New Zealand Intensive Care Society Adult Patient Database. Performance of APACHE III-j at different time points and within different age strata was evaluated by dividing the whole cohort into five 'two-year' groups. Calibration and discrimination were assessed by the Brier score, Hosmer-Lemeshow C and H statistics, Standardised Mortality Ratio (SMR), Cox calibration regression, calibration curves and area under the receiver operating characteristic curve (AUROC). Model performance within diagnostic categories was evaluated. Between 1 January 2000 and 31 December 2009, 558,585 ICU admissions which met inclusion criteria were included in the analysis. The mean (standard deviation) age was 60.8 (18.4) years and 58.3% were male. Overall observed mortality was 12.6%. The mean (standard deviation) APACHE III-j predicted mortality was 14.5% (21.8). Although discrimination (as measured by AUROC) was preserved over time, all other markers of model performance showed deterioration. There was a significant decrease in SMR in eight of ten most common diagnoses examined. This study demonstrates that performance of APACHE III-j model has deteriorated in Australasian hospitals and there is now a clear need for an updated modelling approach to improve mortality prediction, performance monitoring and quality of research undertaken in Australian and New Zealand ICUs.

  3. Applicability of different scoring systems in outcome prediction of patients with mixed drug poisoning-induced coma

    Directory of Open Access Journals (Sweden)

    Nastaran Eizadi Mood

    2011-01-01

    Full Text Available Background: Mixed drugs poisoning (MDP is common in the emergency departments. Because of the limited number of intensive care unit beds, recognition of risk factors to divide the patients into different survival groups is necessary. Poisoning due to ingestion of different medications may have additive or antagonistic effects on different parameters included in the scoring systems; therefore, the aim of the study was to compare applicability of the different scoring systems in outcomes prediction of patients admitted with MDP-induced coma. Methods: This prospective, observational study included 93 patients with MDP-induced coma. Clinical and laboratory data conforming to the Acute Physiology and Chronic Health Evaluation (APACHE II, Modified APACHE II Score (MAS, Mainz Emergency Evaluation Scores (MEES and Glasgow Coma Scale (GCS were recorded for all patients on admission (time 0 and 24 h later (time 24 . The outcome was recorded in two categories: Survived with or without complication and non-survived. Discrimination was evaluated using receiver operating characteristic (ROC curves and area under the ROC curve (AUC. Results: The mortality rate was 9.7%. Mean of each scoring system was statistically significant between time 0 and time 24 in the survivors. However, it was not significant in non-survivors. Discrimination was excellent for GCS 24 (0.90±0.05, APACHE II 24 (0.89±0.01, MAS 24 (0.86±0.10, and APACHE II 0 (0.83±0.11 AUC. Conclusion: The GCS 24 , APACHE II 24 , MAS 24 , and APACHE II 0 scoring systems seem to predict the outcome in comatose patients due to MDP more accurately. GCS and MAS may have superiority over the others in being easy to perform and not requiring laboratory data.

  4. The ability of two scoring systems to predict in-hospital mortality of patients with moderate and severe traumatic brain injuries in a Moroccan intensive care unit

    Directory of Open Access Journals (Sweden)

    Hicham Nejmi

    2014-01-01

    Full Text Available Aim of Study: We aim to assess and to compare the predicting power for in-hospital mortality (IHM of the Acute Physiology and Chronic Health Evaluation-II (APACHE-II and the Simplified Acute Physiology Score-II (SAPS-II for traumatic brain injury (TBI. Patients and Methods: This retrospective cohort study was conducted during a period of 2 years and 9 months in a Moroccan intensive care unit. Data were collected during the first 24 h of each admission. The clinical and laboratory parameters were analyzed and used as per each scoring system to calculate the scores. Univariate and multivariate analyses through regression logistic models were performed, to predict IHM after moderate and severe TBIs. Areas under the receiver operating characteristic curves (AUROC, specificities and sensitivities were determined and also compared. Results: A total of 225 patients were enrolled. The observed IHM was 51.5%. The univariate analysis showed that the initial Glasgow coma scale (GCS was lower in nonsurviving patients (mean GCS = 6 than the survivors (mean GCS = 9 with a statistically significant difference (P = 0.0024. The APACHE-II and the SAPS-II of the nonsurviving patients were higher than those of the survivors (respectively 20.4 ± 6.8 and 31.2 ± 13.6 for nonsurvivors vs. 15.7 ± 5.4 and 22.7 ± 10.3 for survivors with a statistically significant difference (P = 0.0032 for APACHE-II and P = 0.0045 for SAPS-II. Multivariate analysis: APACHE-II was superior for predicting IHM (AUROC = 0.92. Conclusion: The APACHE-II is an interesting tool to predict IHM of head injury patients. This is particularly relevant in Morocco, where TBI is a greater public health problem than in many other countries.

  5. 40 CFR 52.150 - Yavapai-Apache Reservation.

    Science.gov (United States)

    2010-07-01

    ... the Clean Air Act and the provisions of 40 CFR 52.21(g), the Yavapai-Apache Indian Reservation is...) The provisions for prevention of significant deterioration of air quality at 40 CFR 52.21 are... 40 Protection of Environment 3 2010-07-01 2010-07-01 false Yavapai-Apache Reservation....

  6. Go-Gii-Ya [A Jicarilla Apache Religious Celebration].

    Science.gov (United States)

    Pesata, Levi; And Others

    Developed by utilizing only Jicarilla Apache people as resources to preserve the authenticity of the material and information, this booklet presents information on the Jicarilla Apache celebration of "Go-gii-ya". "Go-gii-ya" is a religious feast and ceremony held annually over a three-day period which climaxes on the fifteenth day of September.…

  7. Apache Windows 2003安装指南

    Institute of Scientific and Technical Information of China (English)

    刘永明

    2005-01-01

    Apache 2和PHP是创建交互式网站的流行方案,而且成本很低,在Windows Server 2003中安装Apache 2是一件轻而易举的事情,但要使PHP 5与Apache 2配合无间地运行,就需要一定的技巧。在PHP 5手册的Windows安装小节,没有解释如何让PHP 5与Apache 2配合使用,而有关Apache 2安装的小节缺失了您需要的大量信息。

  8. Preoperative thrombocytosis predicts prognosis in stage II colorectal cancer patients

    Science.gov (United States)

    Lee, Yong Sun; Suh, Kwang Wook

    2016-01-01

    Purpose Thrombocytosis is known to be a poor prognostic factor in several types of solid tumors. The prognostic role of preoperative thrombocytosis in colorectal cancer remains limited. The aim of this study is to investigate the prognostic role of preoperative thrombocytosis in stage II colorectal cancer. Methods Two hundred eighty-four patients with stage II colorectal cancer who underwent surgical resection between December 2003 and December 2009 were retrospectively reviewed. Thrombocytosis was defined as platelet > 450 × 109/L. We compared patients with thrombocytosis and those without thrombocytosis in terms of survival. Results The 5-year disease-free survival (DFS) rates were lower in patients with thrombocytosis compared to those without thrombocytosis in stage II colorectal cancer (73.3% vs. 89.6%, P = 0.021). Cox multivariate analysis demonstrated that thrombocytosis (hazard ratio, 2.945; 95% confidence interval, 1.127–7.697; P = 0.028) was independently associated with DFS in patients with stage II colorectal cancer. Conclusion This study showed that thrombocytosis is a prognostic factor predicting DFS in stage II colorectal cancer patients. PMID:27274508

  9. LHCbDIRAC as Apache Mesos microservices

    CERN Multimedia

    Couturier, Ben

    2016-01-01

    The LHCb experiment relies on LHCbDIRAC, an extension of DIRAC, to drive its offline computing. This middleware provides a development framework and a complete set of components for building distributed computing systems. These components are currently installed and ran on virtual machines (VM) or bare metal hardware. Due to the increased load of work, high availability is becoming more and more important for the LHCbDIRAC services, and the current installation model is showing its limitations. Apache Mesos is a cluster manager which aims at abstracting heterogeneous physical resources on which various tasks can be distributed thanks to so called "framework". The Marathon framework is suitable for long running tasks such as the DIRAC services, while the Chronos framework meets the needs of cron-like tasks like the DIRAC agents. A combination of the service discovery tool Consul together with HAProxy allows to expose the running containers to the outside world while hiding their dynamic placements. Such an arc...

  10. 免费专业的Apache

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Apache是一款免费的软件,可以在www.Apache.org网站的相关链接中下载。目前Apache是应用最广泛的Web服务器软件。整个Internet有半数以上的Web服务器采用Apache,它可以运行在Linux,Windows 9X/NT/2000/XP等多种系统上,Apache的主要优点是稳定性高、速度快、功能强,可扩展性强而且又是免费的,有开放的原代码,便于随

  11. San Carlos Apache Tribe - Energy Organizational Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, James; Albert, Steve

    2012-04-01

    The San Carlos Apache Tribe (SCAT) was awarded $164,000 in late-2011 by the U.S. Department of Energy (U.S. DOE) Tribal Energy Program's "First Steps Toward Developing Renewable Energy and Energy Efficiency on Tribal Lands" Grant Program. This grant funded:  The analysis and selection of preferred form(s) of tribal energy organization (this Energy Organization Analysis, hereinafter referred to as "EOA").  Start-up staffing and other costs associated with the Phase 1 SCAT energy organization.  An intern program.  Staff training.  Tribal outreach and workshops regarding the new organization and SCAT energy programs and projects, including two annual tribal energy summits (2011 and 2012). This report documents the analysis and selection of preferred form(s) of a tribal energy organization.

  12. 急性重症脑梗死病人无创颅内压监测与APACHE II评分的相关性研究

    Institute of Scientific and Technical Information of China (English)

    马驰骋; 陈晶; 念丽; 刘爱军

    2014-01-01

    目的 通过研究急性重症脑梗死病人无创颅内压监测与APACHE II评分的相关性,探讨无创颅内压监测对急性重症脑梗死病人的诊治疗价值。方法 前瞻性研究,所有病例来自2009年1月-2014年4月在我科住院的重症脑梗死病人,共81例,男37例,女44例;入院后立即行急性生理和慢性健康状况评估(APACHE II),根据APACHE II评分情况将81例病人分成三组,第一组APACHE II 3-8分(n=25),第二组APACHE II 9-17分(n=35)第三组APACHE II>17分(n=21)。颅内压监测方法为:在十五分钟内连续监测三次,取三次的平均值作为颅内压监测值。采用pearson相关分析法计算相关系数,分析急性重症脑梗死病人无创颅内压监测与APACHE II评分的相关性。结果 APACHE II评分最高组,其颅内压也为最高,并在入院后第3到5天达到了最高峰,随脑组织水肿情况改善及脱水治疗后,颅内压在随后几天内逐渐下降。对病人颅内压的变化与APACHE II评分进行相关性分析时发现,颅内压与APACHE II评分均呈正相关,并且评分越高的组别与颅内压相关性更显著。结论 无创颅内压监测可以动态地观测重症脑梗死病人的颅内压变化情况,与病人病情APACHE II评分相关性较好。

  13. 76 FR 72969 - Proclaiming Certain Lands as Reservation for the Fort Sill Apache Indian Tribe

    Science.gov (United States)

    2011-11-28

    ... Bureau of Indian Affairs Proclaiming Certain Lands as Reservation for the Fort Sill Apache Indian Tribe... acres, more or less, as the Fort Sill Apache Indian Reservation for the Fort Sill Apache Tribe of... Apache Indian Reservation for the exclusive use of Indians entitled by enrollment or by tribal...

  14. Formal Education and Culture Change, A Modern Apache Indian Community and Government Education Programs.

    Science.gov (United States)

    Parmee, Edward A.

    The study critically examines conditions on the San Carlos Apache Reservation that have resulted from outside manipulation done without regard for the traditional heritage of the Apaches or without provision of training for the Apaches in understanding and facilitating change. The effects of educational experiences available to the Apaches are…

  15. The Trail Inventory of Bosque Del Apache NWR [Cycle 2

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Bosque Del Apache National Wildlife Refuge. Trails in this inventory are...

  16. Social Media Analytics using Apache Spark Application to Market Research

    OpenAIRE

    Gómez Parada, Mauro

    2016-01-01

    En este trabajo se intentará generar una herramienta de marketing de la que se pueda obtener información que puede no estar implícita en Instagram con la ayuda de Apache Spark y Apache Cassandra y con la que luego se podrán optimizar las campañas de publicidad que se hagan en esta red social.

  17. Earlier application of percutaneous cardiopulmonary support rescues patients from severe cardiopulmonary failure using the APACHE III scoring system.

    Science.gov (United States)

    Song, Suk-Won; Yang, Hong-Suk; Lee, Sak; Youn, Young-Nam; Yoo, Kyung-Jong

    2009-12-01

    Percutaneous cardiopulmonary support (PCPS) is a widely accepted treatment for severe cardiopulmonary failure. This system, which uses a percutaneous approach and autopriming devices, can be rapidly applied in emergency situations. We sought to identify the risk factors that could help predict in-hospital mortality, and to assess its outcomes in survivors. During a 2-yr period, 50 patients underwent PCPS for the treatment of severe cardiopulmonary failure, and of those, 22 (44%) were classified as survivors and 28 (56%) as non-survivors. We compared the 2 groups for risk factors of in-hospital mortality and to establish proper PCPS timing. Twenty patients underwent PCPS for acute myocardial infarction, 20 for severe cardiopulmonary failure after cardiac surgery, 7 for acute respiratory distress syndrome, and 3 for acute myocarditis. Multivariate analysis showed that an acute physiology, age, and chronic health evaluation (APACHE) III score >or=50 prior to PCPS was the only significant predictor of in-hospital mortality (P=0.001). Overall 18-month survival was 42.2%. Cox analysis showed patients with APACHE III scores >or=50 had a poor prognosis (P=0.001). Earlier application of PCPS, and other preemptive strategies designed to optimize high-risk patients, may improve patient outcomes. Identifying patients with high APACHE scores at the beginning of PCPS may predict in-hospital mortality. Survivors, particularly those with higher APACHE scores, may require more frequent follow-up to improve overall survival.

  18. Identification of enhanced cytokine generation following sepsis. Dream of magic bullet for mortality prediction and therapeutic evaluation

    Directory of Open Access Journals (Sweden)

    H Hamishehkar

    2010-09-01

    Full Text Available "n  "nBackground and the purpose of the study: sepsis is one of the most widespread and lethal disease in Intensive Care Units (ICU. Based on pathophisyology of sepsis, it seems that routine laboratory tests combined with analysis of pro-inflammatory cytokines plasma levels, help clinicians to have more information about disease progress and its correct management. "nMethods:This was a prospective observational study to determine the predictive role of Tumor Necrosis Factor alpha (TNF-α, Interleukin (IL-1β and IL-6 as three main pro-inflammatory cytokines and Acute Physiology and Chronic Health Evaluation (APACHE II and Sequential Organ Failure Assessment (SOFA as two scoring systems in mortality of critically ill patients with severe sepsis. Fifty and five patients with criteria of severe sepsis were included in this study. An exclusion criterion was post Cardiopulmonary Resuscitation (CPR status. Cytokines (TNF-α, IL-1β and IL-6 were assayed in the first, third and seventh days in blood of patients. Results and major conclusion:Among three measured cytokines, sequential levels of TNF-α and IL-6 showed significant differences between survivors and nonsurvivors. IL-6 had a good correlation with outcome and scoring systems during the period of this study. The areas under the receiver operating characteristic (AUROC curve indicated that APACHE II (0.858, 0.848, 0.861 and IL-6 (0.797, 0.799, 0.899 had discriminative power in prediction of mortality during sequental measured days. Multiple logestic regression analysis identified that evaluation of APACHE II and TNF-α in the first day and APACHE II and IL-6 in the third and seventh days of severe septic patients are independent outcome predictors. Results of this study suggest that IL-6 and APACHE II are useful cytokine and scoring systems respectively in prediction of mortality and clinical evaluation of severe septic patients.

  19. Controls for a Pulsed Ion Accelerator Using Apache Cassandra (No-SQL) and ZMQ

    CERN Document Server

    Persaud, A; Stettler, M W; Vytla, V K

    2015-01-01

    We report on updates to the accelerator controls for the Neutral Drift Compression Experiment II, a pulsed accelerator for heavy ions. The control infrastructure is built around a LabVIEW interface combined with an Apache Cassandra (No-SQL) backend for data archiving. Recent upgrades added the storing and retrieving of device settings into the database, as well as adding ZMQ as a message broker that replaces LabVIEW's shared variables. Converting to ZMQ also allows easy access using other programming languages, such as Python.

  20. SAPS 3, APACHE IV or GRACE: which score to choose for acute coronary syndrome patients in intensive care units?

    Directory of Open Access Journals (Sweden)

    Antonio Paulo Nassar Junior

    Full Text Available CONTEXT AND OBJECTIVE Acute coronary syndromes (ACS are a common cause of intensive care unit (ICU admission. Specific prognostic scores have been developed and validated for ACS patients and, among them, GRACE (Global Registry of Acute Coronary Events has had the best performance. However, intensive care clinicians generally use prognostic scores developed from heterogeneous populations of critically ill patients, such as APACHE IV (Acute Physiologic and Chronic Health Evaluation IV and SAPS 3 (Simplified Acute Physiology Score 3. The aim of this study was to evaluate and compare the performance of these three scores in a non-selected population of ACS cases. DESIGN AND SETTING Retrospective observational study to evaluate three prognostic scores in a population of ACS patients admitted to three general ICUs in private hospitals in São Paulo. METHODS All patients with ACS admitted from July 2008 to December 2009 were considered for inclusion in the study. Score calibration and discrimination were evaluated in relation to predicting hospital mortality. RESULTS A total of 1065 patients were included. The calibration was appropriate for APACHE IV and GRACE but not for SAPS 3. The discrimination was very good for all scores (area under curve of 0.862 for GRACE, 0.860 for APACHE IV and 0.804 for SAPS 3. CONCLUSIONS In this population of ACS patients admitted to ICUs, GRACE and APACHE IV were adequately calibrated, but SAPS 3 was not. All three scores had very good discrimination. GRACE and APACHE IV may be used for predicting mortality risk among ACS patients.

  1. SAPS 3, APACHE IV or GRACE: which score to choose for acute coronary syndrome patients in intensive care units?

    Science.gov (United States)

    Nassar Junior, Antonio Paulo; Mocelin, Amilcar Oshiro; Andrade, Fabio Moreira; Brauer, Leonardo; Giannini, Fabio Poianas; Nunes, Andre Luiz Baptiston; Dias, Carlos Augusto

    2013-01-01

    CONTEXT AND OBJECTIVE Acute coronary syndromes (ACS) are a common cause of intensive care unit (ICU) admission. Specific prognostic scores have been developed and validated for ACS patients and, among them, GRACE (Global Registry of Acute Coronary Events) has had the best performance. However, intensive care clinicians generally use prognostic scores developed from heterogeneous populations of critically ill patients, such as APACHE IV (Acute Physiologic and Chronic Health Evaluation IV) and SAPS 3 (Simplified Acute Physiology Score 3). The aim of this study was to evaluate and compare the performance of these three scores in a non-selected population of ACS cases. DESIGN AND SETTING Retrospective observational study to evaluate three prognostic scores in a population of ACS patients admitted to three general ICUs in private hospitals in São Paulo. METHODS All patients with ACS admitted from July 2008 to December 2009 were considered for inclusion in the study. Score calibration and discrimination were evaluated in relation to predicting hospital mortality. RESULTS A total of 1065 patients were included. The calibration was appropriate for APACHE IV and GRACE but not for SAPS 3. The discrimination was very good for all scores (area under curve of 0.862 for GRACE, 0.860 for APACHE IV and 0.804 for SAPS 3). CONCLUSIONS In this population of ACS patients admitted to ICUs, GRACE and APACHE IV were adequately calibrated, but SAPS 3 was not. All three scores had very good discrimination. GRACE and APACHE IV may be used for predicting mortality risk among ACS patients.

  2. San Carlos Apache Indian Reservation and Bylas, Arizona; Fort Thomas Public Schools. National Study of American Indian Education, Series 1, No. 18, Final Report.

    Science.gov (United States)

    Chilcott, John H.; Anderson, Ned

    As part of the Final Report of the National Study of American Indian Education, Part I of this document depicts the demographic, socioeconomic, educational, and social aspects of the San Carlos Apache Indian Reservation and community of Bylas. Part II places specific emphasis on recent history, economy, problems and new programs, and the…

  3. 75 FR 68607 - BP Canada Energy Marketing Corp. Apache Corporation; Notice for Temporary Waivers

    Science.gov (United States)

    2010-11-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission BP Canada Energy Marketing Corp. Apache Corporation; Notice for Temporary... Apache Corporation filed with the Federal Energy Regulatory Commission a Joint Petition for...

  4. Peak-summer East Asian rainfall predictability and prediction part II: extratropical East Asia

    Science.gov (United States)

    Yim, So-Young; Wang, Bin; Xing, Wen

    2016-07-01

    The part II of the present study focuses on northern East Asia (NEA: 26°N-50°N, 100°-140°E), exploring the source and limit of the predictability of the peak summer (July-August) rainfall. Prediction of NEA peak summer rainfall is extremely challenging because of the exposure of the NEA to midlatitude influence. By examining four coupled climate models' multi-model ensemble (MME) hindcast during 1979-2010, we found that the domain-averaged MME temporal correlation coefficient (TCC) skill is only 0.13. It is unclear whether the dynamical models' poor skills are due to limited predictability of the peak-summer NEA rainfall. In the present study we attempted to address this issue by applying predictable mode analysis method using 35-year observations (1979-2013). Four empirical orthogonal modes of variability and associated major potential sources of variability are identified: (a) an equatorial western Pacific (EWP)-NEA teleconnection driven by EWP sea surface temperature (SST) anomalies, (b) a western Pacific subtropical high and Indo-Pacific dipole SST feedback mode, (c) a central Pacific-El Nino-Southern Oscillation mode, and (d) a Eurasian wave train pattern. Physically meaningful predictors for each principal component (PC) were selected based on analysis of the lead-lag correlations with the persistent and tendency fields of SST and sea-level pressure from March to June. A suite of physical-empirical (P-E) models is established to predict the four leading PCs. The peak summer rainfall anomaly pattern is then objectively predicted by using the predicted PCs and the corresponding observed spatial patterns. A 35-year cross-validated hindcast over the NEA yields a domain-averaged TCC skill of 0.36, which is significantly higher than the MME dynamical hindcast (0.13). The estimated maximum potential attainable TCC skill averaged over the entire domain is around 0.61, suggesting that the current dynamical prediction models may have large rooms to improve

  5. Ergonomic and anthropometric issues of the forward Apache crew station

    NARCIS (Netherlands)

    Oudenhuijzen, A.J.K.

    1999-01-01

    This paper describes the anthropometric accommodation in the Apache crew systems. These activities are part of a comprehensive project, in a cooperative effort from the Armstrong Laboratory at Wright Patterson Air Force Base (Dayton, Ohio, USA) and TNO Human Factors Research Institute (TNO HFRI) in

  6. Interrupting White Mountain Apache Language Shift: An Insider's View.

    Science.gov (United States)

    Adley-SantaMaria, Bernadette

    1999-01-01

    A White Mountain Apache (WMA) doctoral student collaborating with a non-Indian linguist on a grammar book project discusses the status of the WMA language; causes of WMA language shift; aspects of insider-outsider collaboration; implications for revitalization and maintenance of indigenous languages; and the responsibilities of individuals,…

  7. Ergonomic and anthropometric issues of the forward Apache crew station

    NARCIS (Netherlands)

    Oudenhuijzen, A.J.K.

    1999-01-01

    This paper describes the anthropometric accommodation in the Apache crew systems. These activities are part of a comprehensive project, in a cooperative effort from the Armstrong Laboratory at Wright Patterson Air Force Base (Dayton, Ohio, USA) and TNO Human Factors Research Institute (TNO HFRI) in

  8. Nutrition Survey of White Mountain Apache Preschool Children.

    Science.gov (United States)

    Owen, George M.; And Others

    As part of a national study of the nutrition of preschool children, data were collected on 201 Apache children, 1 to 6 years of age, living on an Indian reservation in Arizona. This report reviews procedures and clinical findings, and gives an analysis of growth data including skeletal maturation, nutrient intakes and clinical biochemical data. In…

  9. Interfacing RASCAL with Java APIs. Automated mapping with Apache POI

    NARCIS (Netherlands)

    Marmanidis, G.

    2013-01-01

    Interfacing RASCAL with Java APIs and reusing existing implementations is a required functionality in order to reduce effort and time in contrast with implementing a new one from scratch. In this study we are trying to interface RASCAL with Apache POI, a Java implemented API in order to import and a

  10. An Exploratory Study of Apache Middle School Students' Computer Animation.

    Science.gov (United States)

    Stokrocki, Mary; Buckpitt, Marcia

    The paper describes a participant observation study of a 3 week summer art program for Apache middle school students on the White Mountain Reservation. Computer art skills, specifically animation using a menu-driven computer paint program, were the focus of the investigation. Because it was in the context of a summer program, instruction was…

  11. Issues in Language Textbook Development: The Case of Western Apache.

    Science.gov (United States)

    de Reuse, Willem J.

    Two experimental language-learning textbooks were developed in collaboration with Apache-speaking scholars from the San Carlos and White Mountain Reservations. One was written in the grammar-translation tradition and modeled after successful textbooks for Navajo and Papago. While the text's main purpose is to teach elementary conversational…

  12. The Apache Point Observatory Galactic Evolution Experiment (APOGEE)

    DEFF Research Database (Denmark)

    Majewski, Steven R.; Schiavon, Ricardo P.; Frinchaboy, Peter M.

    2017-01-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE), one of the programs in the Sloan Digital Sky Survey III (SDSS-III), has now completed its systematic, homogeneous spectroscopic survey sampling all major populations of the Milky Way. After a three-year observing campaign on the...

  13. The White Mountain Apache Child Protection Service Training Curriculum. Nohwii Chaghashe Baa da gontzaa (Protect Our Apache Children).

    Science.gov (United States)

    Gonzalez-Santin, Edwin, Comp.

    This curriculum manual provides 8 days of training for child protective services (CPS) personnel (social workers and administrators) working in the White Mountain Apache tribal community. Each of the first seven units in the manual contains a brief description of contents, course objectives, time required, key concepts, possible discussion topics,…

  14. SOX9 Expression Predicts Relapse of Stage II Colon Cancer Patients

    DEFF Research Database (Denmark)

    Espersen, Maiken Lise Marcker; Linnemann, Dorte; Alamili, Mahdi;

    2016-01-01

    The aim of this study was to investigate if the protein expression of Sex-determining region y-box 9 (SOX9) in primary tumors could predict relapse of stage II colon cancer patients.144 patients with stage II primary colon cancer were retrospectively enrolledin the study. SOX9 expression...... high levels of SOX9 of primary stage II colon tumors predict low riskof relapse whereas low levels of SOX9 predict high risk of relapse. SOX9 may have an important value as a biomarker when evaluating risk of relapse for personalized treatment....

  15. Mobile Big Data Analytics Using Deep Learning and Apache Spark

    OpenAIRE

    Alsheikh, Mohammad Abu; Niyato, Dusit; Lin, Shaowei; Tan, Hwee-Pink; Han, Zhu

    2016-01-01

    The proliferation of mobile devices, such as smartphones and Internet of Things (IoT) gadgets, results in the recent mobile big data (MBD) era. Collecting MBD is unprofitable unless suitable analytics and learning methods are utilized for extracting meaningful information and hidden patterns from data. This article presents an overview and brief tutorial of deep learning in MBD analytics and discusses a scalable learning framework over Apache Spark. Specifically, a distributed deep learning i...

  16. AH-64E Apache Remanufacture (AH-64E Remanufacture)

    Science.gov (United States)

    2013-12-01

    BY - Base Year DAMIR - Defense Acquisition Management Information Retrieval Dev Est - Development Estimate DoD - Department of Defense DSN - Defense...2009 NOV 2009 MAY 2010 NOV 2009 Milestone C JUL 2010 JUL 2010 JAN 2011 SEP 2010 IOT &E MAR 2012 MAR 2012 SEP 2012 MAR 2012 FRP JUL 2012 JUL 2012 JAN...AB3A - Apache Block 3A EMD - Engineering Manufacturing and Development FRP - Full Rate Production IOT &E - Initial Operational Test and Evaluation

  17. Efficacy of Various Scoring Systems for Predicting the 28-Day Survival Rate among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Requiring Emergency Intensive Care

    Directory of Open Access Journals (Sweden)

    Zhihong Feng

    2017-01-01

    Full Text Available We aimed to investigate the efficacy of four severity-of-disease scoring systems in predicting the 28-day survival rate among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD requiring emergency care. Clinical data of patients with AECOPD who required emergency care were recorded over 2 years. APACHE II, SAPS II, SOFA, and MEDS scores were calculated from severity-of-disease indicators recorded at admission and compared between patients who died within 28 days of admission (death group; 46 patients and those who did not (survival group; 336 patients. Compared to the survival group, the death group had a significantly higher GCS score, frequency of comorbidities including hypertension and heart failure, and age (P<0.05 for all. With all four systems, scores of age, gender, renal inadequacy, hypertension, coronary heart disease, heart failure, arrhythmia, anemia, fracture leading to bedridden status, tumor, and the GCS were significantly higher in the death group than the survival group. The prediction efficacy of the APACHE II and SAPS II scores was 88.4%. The survival rates did not differ significantly between APACHE II and SAPS II (P=1.519. Our results may guide triage for early identification of critically ill patients with AECOPD in the emergency department.

  18. Solar Feasibility Study May 2013 - San Carlos Apache Tribe

    Energy Technology Data Exchange (ETDEWEB)

    Rapp, Jim [Parametrix; Duncan, Ken [San Carlos Apache Tribe; Albert, Steve [Parametrix

    2013-05-01

    The San Carlos Apache Tribe (Tribe) in the interests of strengthening tribal sovereignty, becoming more energy self-sufficient, and providing improved services and economic opportunities to tribal members and San Carlos Apache Reservation (Reservation) residents and businesses, has explored a variety of options for renewable energy development. The development of renewable energy technologies and generation is consistent with the Tribe’s 2011 Strategic Plan. This Study assessed the possibilities for both commercial-scale and community-scale solar development within the southwestern portions of the Reservation around the communities of San Carlos, Peridot, and Cutter, and in the southeastern Reservation around the community of Bylas. Based on the lack of any commercial-scale electric power transmission between the Reservation and the regional transmission grid, Phase 2 of this Study greatly expanded consideration of community-scale options. Three smaller sites (Point of Pines, Dudleyville/Winkleman, and Seneca Lake) were also evaluated for community-scale solar potential. Three building complexes were identified within the Reservation where the development of site-specific facility-scale solar power would be the most beneficial and cost-effective: Apache Gold Casino/Resort, Tribal College/Skill Center, and the Dudleyville (Winkleman) Casino.

  19. Project Apache: A Reservation, Community-Based Early Intervention Program for Apache Infants and Toddlers with Special Needs and Their Families.

    Science.gov (United States)

    O'Connell, Joanne C.

    This final report describes the outcomes of Project Apache, a reservation, community-based early intervention program designed to develop comprehensive services to Apache infants and toddlers who are at risk of developing a disability and their families. The project uses a home-based service delivery program with paraprofessional aides to assist…

  20. Predicting Scores of Beginning Agricultural Education Teachers on the Praxis II Examination

    Science.gov (United States)

    Thobega, Moreetsi; Miller, Greg

    2008-01-01

    This descriptive-correlational study predicted performance of beginning agricultural education teachers on principles of learning and teaching (PLT) and Agriculture content (AgC) tests of the PRAXIS II examination using demographic and academic variables. Performance on the PRAXIS II was used for issuing initial teaching licenses to the…

  1. Chaotic time series. Part II. System Identification and Prediction

    Directory of Open Access Journals (Sweden)

    Bjørn Lillekjendlie

    1994-10-01

    Full Text Available This paper is the second in a series of two, and describes the current state of the art in modeling and prediction of chaotic time series. Sample data from deterministic non-linear systems may look stochastic when analysed with linear methods. However, the deterministic structure may be uncovered and non-linear models constructed that allow improved prediction. We give the background for such methods from a geometrical point of view, and briefly describe the following types of methods: global polynomials, local polynomials, multilayer perceptrons and semi-local methods including radial basis functions. Some illustrative examples from known chaotic systems are presented, emphasising the increase in prediction error with time. We compare some of the algorithms with respect to prediction accuracy and storage requirements, and list applications of these methods to real data from widely different areas.

  2. The Perfect Way to Predict the Severity of Acute Pancreatitis: The Search Continues

    Directory of Open Access Journals (Sweden)

    Daniel C Sadowski

    2004-01-01

    Full Text Available This study was designed to determine the clinical utility of three rating scales (Ranson's, Acute Physiology And Chronic Health Evaluation [APACHE] II and Glasgow in predicting the severity of acute pancreatitis experienced by patients known to have human immunodeficiency virus (HIV or acquired immunodeficiency syndrome (AIDS. A retrospective analysis identified 73 patients with both acute pancreatitis and HIV who had been admitted to two Canadian hospitals between 1989 and 1999. Of those 73, 11 (15% went on to have a clinical course consistent with a diagnosis of severe pancreatitis. For the purposes of the study, severe pancreatitis was defined by the occurrence of death, intensive care unit admission, surgical intervention or significant symptomatic local complications (necrosis, abscess or pseudocyst. The authors found that the APACHE II and Ranson's scores had a sensitivity of 100% and specificities of 70% and 33% for severe pancreatitis, respectively. The Glasgow score had a statistically poorer diagnostic performance.

  3. Apache 2.4 Evaluation and Integration with the Existing Middleware Infrastructure

    CERN Document Server

    Hubinek, Tomas

    2013-01-01

    This document is a Summer Student Work Project Report. It describes main goals and outcomes of Tomas Hubinek's work in CERN. The aim of this project was to investigate new features offered by Apache HTTP server 2.4 and to test different types of connections between front-end Apache server and back-end application servers, namely Apache Tomcat and WebLogic, with SSL support.

  4. Perl and Apache Your visual blueprint for developing dynamic Web content

    CERN Document Server

    McDaniel, Adam

    2010-01-01

    Visually explore the range of built-in and third-party libraries of Perl and Apache. Perl and Apache have been providing Common Gateway Interface (CGI) access to Web sites for 20 years and are constantly evolving to support the ever-changing demands of Internet users. With this book, you will heighten your knowledge and see how to usePerl and Apache to develop dynamic Web sites. Beginning with a clear, step-by-step explanation of how to install Perl and Apache on both Windows and Linux servers, you then move on to configuring each to securely provide CGI Services. CGI developer and author Adam

  5. Beginning PHP, Apache, MySQL web development

    CERN Document Server

    Glass, Michael K; Naramore, Elizabeth; Mailer, Gary; Stolz, Jeremy; Gerner, Jason

    2004-01-01

    An ideal introduction to the entire process of setting up a Web site using PHP (a scripting language), MySQL (a database management system), and Apache (a Web server)* Programmers will be up and running in no time, whether they're using Linux or Windows servers* Shows readers step by step how to create several Web sites that share common themes, enabling readers to use these examples in real-world projects* Invaluable reading for even the experienced programmer whose current site has outgrown the traditional static structure and who is looking for a way to upgrade to a more efficient, user-f

  6. Instant Apache Solr for indexing data how-to

    CERN Document Server

    Rafalovitch, Alexandre

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. This book is written in a friendly, practical manner with recipes covering important indexing techniques and methods using Apache Solr.This book is for developers who want to dive deeper into Solr. Regardless of whether you are just starting with Solr or have already built your first collection by copying and modifying examples, this book will take you through the complicated steps of indexing your data with Solr.

  7. Large-Scale Graph Processing Using Apache Giraph

    KAUST Repository

    Sakr, Sherif

    2017-01-07

    This book takes its reader on a journey through Apache Giraph, a popular distributed graph processing platform designed to bring the power of big data processing to graph data. Designed as a step-by-step self-study guide for everyone interested in large-scale graph processing, it describes the fundamental abstractions of the system, its programming models and various techniques for using the system to process graph data at scale, including the implementation of several popular and advanced graph analytics algorithms.

  8. Association of serum interleukin-6, interleukin-8, and Acute Physiology and Chronic Health Evaluation II score with clinical outcome in patients with acute respiratory distress syndrome

    Science.gov (United States)

    Swaroopa, Deme; Bhaskar, Kakarla; Mahathi, T.; Katkam, Shivakrishna; Raju, Y. Satyanarayana; Chandra, Naval; Kutala, Vijay Kumar

    2016-01-01

    Background and Aim: Studies on potential biomarkers in experimental models of acute lung injury (ALI) and clinical samples from patients with ALI have provided evidence to the pathophysiology of the mechanisms of lung injury and predictor of clinical outcome. Because of the high mortality and substantial variability in outcomes in patients with acute respiratory distress syndrome (ARDS), identification of biomarkers such as cytokines is important to determine prognosis and guide clinical decision-making. Materials and Methods: In this study, we have included thirty patients admitted to Intensive Care Unit diagnosed with ARDS, and serum samples were collected on day 1 and 7 and were analyzed for serum interleukin-6 (IL-6) and IL-8 by ELISA method, and Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring was done on day 1. Results: The mortality in the patients observed with ARDS was 34%. APACHE II score was significantly higher in nonsurvivors as compared to survivors. There were no significant differences in gender and biochemical and hematological parameters among the survivors and nonsurvivors. Serum IL-6 and IL-8 levels on day 1 were significantly higher in all the ARDS patients as compared to healthy controls and these levels were returned to near-normal basal levels on day 7. The serum IL-6 and IL-8 levels measured on day 7 were of survivors. As compared to survivors, the IL-6 and IL-8 levels were significantly higher in nonsurvivors measured on day 1. Spearman's rank correlation analysis indicated a significant positive correlation of APACHE II with IL-8. By using APACHE II score, IL-6, and IL-8, the receiver operating characteristic curve was plotted and the provided predictable accuracy of mortality (outcome) was 94%. Conclusion: The present study highlighted the importance of measuring the cytokines such as IL-6 and IL-8 in patients with ARDS in predicting the clinical outcome. PMID:27688627

  9. MODIS derived vegetation index for drought detection on the San Carlos Apache Reservation

    Science.gov (United States)

    Wu, Zhuoting; Velasco, Miguel G.; McVay, Jason; Middleton, Barry R.; Vogel, John M.; Dye, Dennis G.

    2016-01-01

    A variety of vegetation indices derived from remotely sensed data have been used to assess vegetation conditions, enabling the identification of drought occurrences as well as the evaluation of drought impacts. Moderate Resolution Imaging Spectroradiometer (MODIS) Terra 8-day composite data were used to compute the Modified Soil Adjusted Vegetation Index II (MSAVI2) of four dominant vegetation types over a 13-year period (2002 – 2014) on the San Carlos Apache Reservation in Arizona, US. MSAVI2 anomalies were used to identify adverse impacts of drought on vegetation, characterized as mean MSAVI2 below the 13-year average. In terms of interannual variability, we found similar responses between grassland and shrubland, and between woodland and forest vegetation types. We compared MSAVI2 for specific vegetation types with precipitation data at the same time step, and found a lag time of roughly two months for the peak MSAVI2 values following precipitation in a given year. All vegetation types responded to summer monsoon rainfall, while shrubland and annual herbaceous vegetation also displayed a brief spring growing season following winter snowmelt. MSAVI2 values of shrublands corresponded well with precipitation variability both for summer rainfall and winter snowfall, and can be potentially used as a drought indicator on the San Carlos Apache Reservation given its wide geographic distribution. We demonstrated that moderate temporal frequency satellite-based MSAVI2 can provide drought monitoring to inform land management decisions, especially on vegetated tribal land areas where in situ precipitation data are limited.

  10. Vegetative response to water availability on the San Carlos Apache Reservation

    Science.gov (United States)

    Petrakis, Roy; Wu, Zhuoting; McVay, Jason; Middleton, Barry R.; Dye, Dennis G.; Vogel, John M.

    2016-01-01

    On the San Carlos Apache Reservation in east-central Arizona, U.S.A., vegetation types such as ponderosa pine forests, pinyon-juniper woodlands, and grasslands have significant ecological, cultural, and economic value for the Tribe. This value extends beyond the tribal lands and across the Western United States. Vegetation across the Southwestern United States is susceptible to drought conditions and fluctuating water availability. Remotely sensed vegetation indices can be used to measure and monitor spatial and temporal vegetative response to fluctuating water availability conditions. We used the Moderate Resolution Imaging Spectroradiometer (MODIS)-derived Modified Soil Adjusted Vegetation Index II (MSAVI2) to measure the condition of three dominant vegetation types (ponderosa pine forest, woodland, and grassland) in response to two fluctuating environmental variables: precipitation and the Standardized Precipitation Evapotranspiration Index (SPEI). The study period covered 2002 through 2014 and focused on a region within the San Carlos Apache Reservation. We determined that grassland and woodland had a similar moderate to strong, year-round, positive relationship with precipitation as well as with summer SPEI. This suggests that these vegetation types respond negatively to drought conditions and are more susceptible to initial precipitation deficits. Ponderosa pine forest had a comparatively weaker relationship with monthly precipitation and summer SPEI, indicating that it is more buffered against short-term drought conditions. This research highlights the response of multiple, dominant vegetation types to seasonal and inter-annual water availability. This research demonstrates that multi-temporal remote sensing imagery can be an effective tool for the large scale detection of vegetation response to adverse impacts from climate change and support potential management practices such as increased monitoring and management of drought-affected areas. Different

  11. Deletion of Chromosome 4q Predicts Outcome in Stage II Colon Cancer Patients

    Directory of Open Access Journals (Sweden)

    R. P. M. Brosens

    2010-01-01

    Full Text Available Background: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters to identify high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, have been established. With traditional histopathological features definition of high-risk stage II colon cancer patients is inaccurate. Therefore more objective and robust markers for prediction of relapse are needed. DNA copy number aberrations have proven to be robust prognostic markers, but have not yet been investigated for this specific group of patients. The aim of the present study was to identify chromosomal aberrations that can predict relapse of tumor in patients with stage II colon cancer.

  12. Evaluation of Apache Hadoop for parallel data analysis with ROOT

    Science.gov (United States)

    Lehrack, S.; Duckeck, G.; Ebke, J.

    2014-06-01

    The Apache Hadoop software is a Java based framework for distributed processing of large data sets across clusters of computers, using the Hadoop file system (HDFS) for data storage and backup and MapReduce as a processing platform. Hadoop is primarily designed for processing large textual data sets which can be processed in arbitrary chunks, and must be adapted to the use case of processing binary data files which cannot be split automatically. However, Hadoop offers attractive features in terms of fault tolerance, task supervision and control, multi-user functionality and job management. For this reason, we evaluated Apache Hadoop as an alternative approach to PROOF for ROOT data analysis. Two alternatives in distributing analysis data were discussed: either the data was stored in HDFS and processed with MapReduce, or the data was accessed via a standard Grid storage system (dCache Tier-2) and MapReduce was used only as execution back-end. The focus in the measurements were on the one hand to safely store analysis data on HDFS with reasonable data rates and on the other hand to process data fast and reliably with MapReduce. In the evaluation of the HDFS, read/write data rates from local Hadoop cluster have been measured and compared to standard data rates from the local NFS installation. In the evaluation of MapReduce, realistic ROOT analyses have been used and event rates have been compared to PROOF.

  13. Modeling transducer impulse responses for predicting calibrated pressure pulses with the ultrasound simulation program Field II

    DEFF Research Database (Denmark)

    Bæk, David; Jensen, Jørgen Arendt; Willatzen, Morten

    2010-01-01

    FIELD II is a simulation software capable of predicting the field pressure in front of transducers having any complicated geometry. A calibrated prediction with this program is, however, dependent on an exact voltage-to-surface acceleration impulse response of the transducer. Such impulse response...... is not calculated by FIELD II. This work investigates the usability of combining a one-dimensional multilayer transducer modeling principle with the FIELD II software. Multilayer here refers to a transducer composed of several material layers. Measurements of pressure and current from Pz27 piezoceramic disks...... as well as pressure and intensity measurements in front of a 128 element commercial convex medical transducer are compared to the simulations. Results show that the models can predict the pressure from the piezoceramic disks with a root mean square (rms) error of 11.2% to 36.2% with a 2 dB amplitude...

  14. Quantum Chemical Studies on the Prediction of Structures, Charge Distributions and Vibrational Spectra of Some Ni(II), Zn(II), and Cd(II) Iodide Complexes

    Science.gov (United States)

    Bardakci, Tayyibe; Kumru, Mustafa; Altun, Ahmet

    2016-06-01

    Transition metal complexes play an important role in coordination chemistry as well as in the formation of metal-based drugs. In order to obtain accurate results for studying these type of complexes quantum chemical studies are performed and especially density functional theory (DFT) has become a promising choice. This talk represents molecular structures, charge distributions and vibrational analysis of Ni(II), Zn(II), and Cd(II) iodide complexes of p-toluidine and m-toluidine by means of DFT. Stable structures of the ligands and the related complexes have been obtained in the gas phase at B3LYP/def2-TZVP level and calculations predict Ni(II) complexes as distorted polymeric octahedral whereas Zn(II) and Cd(II) complexes as distorted tetrahedral geometries. Charge distribution analysis have been performed by means of Mulliken, NBO and APT methods and physically most meaningful method for our compounds is explained. Vibrational spectra of the title compounds are computed from the optimized geometries and theoretical frequencies are compared with the previously obtained experimental data. Since coordination occurs via nitrogen atoms of the free ligands, N-H stretching bands of the ligands are shifted towards lower wavenumbers in the complexes whereas NH_2 wagging and twisting vibrations are shifted towards higher wavenumbers.

  15. External validation of Acute Physiology and Chronic Health Evaluation IV in Dutch intensive care units and comparison with Acute Physiology and Chronic Health Evaluation II and Simplified Acute Physiology Score II

    NARCIS (Netherlands)

    S. Brinkman; F. Bakhshi-Raiez; A. Abu-Hanna; E. de Jonge; R.J. Bosman; L. Peelen; N.F. de Keizer

    2011-01-01

    Purpose: The aim of this study was to validate and compare the performance of the Acute Physiology and Chronic Health Evaluation (APACHE) IV in the Dutch intensive care unit (ICU) population to the APACHE II and Simplified Acute Physiology Score (SAPS) II. Materials and Methods: This is a prospectiv

  16. The predictive value of resting heart rate following osmotherapy in brain injury: back to basics

    Directory of Open Access Journals (Sweden)

    Hasanpour Mir Mahsa

    2012-12-01

    Full Text Available Abstract Background The importance of resting heart rate as a prognostic factor was described in several studies. An elevated heart rate is an independent risk factor for adverse cardiovascular events and total mortality in patients with coronary artery disease, chronic heart failure, and the general population. Also heart rate is elevated in the Multi Organ Dysfunction Syndrome (MODS and the mortality due to MODS is highly correlated with inadequate sinus tachycardia. To evaluate the value of resting heart rate in predicting mortality in patients with traumatic brain injury along scoring systems like Acute Physiology and Chronic Health Evaluation(APACHE II, Sequential Organ Failure Assessment (SOFA and Glasgow Coma Score (GCS. Method By analyzing data which was collected from an open labeled randomized clinical trial that compared the different means of osmotherapy (mannitol vs bolus or infusion hypertonic saline, heart rate, GCS, APACHE II and SOFA score were measured at baseline and daily for 7 days up to 60 days and the relationship between elevated heart rate and mortality during the first 7 days and 60th day were assessed. Results After adjustments for confounding factors, although there was no difference in mean heart rate between either groups of alive and expired patients, however, we have found a relative correlation between 60th day mortality rate and resting heart rate (P=0.07. Conclusion Heart rate can be a prognostic factor for estimating mortality rate in brain injury patients along with APACHE II and SOFA scores in patients with brain injury.

  17. The Predictive Value of Resting Heart rate Following Osmotherapy in Brain injury: Back to Basics

    Directory of Open Access Journals (Sweden)

    Mahsa Hasanpour Mir

    2012-12-01

    Full Text Available Background: The importance of resting heart rate as a prognostic factor was described in several studies. An elevated heart rate is an independent risk factor for adverse cardiovascular events and total mortality in patients with coronary artery disease, chronic heart failure, and the general population. Also heart rate is elevated in the Multi Organ Dysfunction Syndrome (MODS and the mortality due to MODS is highly correlated with inadequate sinus tachycardia.To evaluate the value of resting heart rate in predicting mortality in patients with traumatic brain injury along scoring systems like Acute Physiology and Chronic Health Evaluation(APACHE II, Sequential Organ Failure Assessment (SOFA and Glasgow Coma Score (GCS.Method: By analyzing data which was collected from an open labeled randomized clinical trial that compared the different means of osmotherapy (mannitol vs bolus or infusion hypertonic saline, heart rate, GCS, APACHE II and SOFA score were measured at baseline and daily for 7 days up to 60 days and the relationship between elevatedheart rate and mortality during the first 7 days and 60th day were assessed.Results: After adjustments for confounding factors, although there was no difference in mean heart rate between either groups of alive and expired patients, however, we have found a relative correlation between 60th day mortality rate and resting heart rate (P=0.07.Conclusion: Heart rate can be a prognostic factor for estimating mortality rate in brain injury patients along with APACHE II and SOFA scores in patients with brain injury.Keywords: Heart rate, APACHE II score, SOFA score, GCS score, Head injury

  18. Analyses of Apach Commons HttpClient Programming in Chinese OS Platform%浅析中文环境下的Apach Commons HttpClient编程

    Institute of Scientific and Technical Information of China (English)

    洪亮; 田支斌

    2008-01-01

    本文详尽的分析了在中文环境下运用Apach Commons HttpClient进行编程时出现的几个常见问题.针对每个问题,本文均给出较为完善的解决方案,对中文环境下的Apach Commons HttpClient编程具有极大的现实参考价值.

  19. Biology and distribution of Lutzomyia apache as it relates to VSV

    Science.gov (United States)

    Phlebotomine sand flies are vectors of bacteria, parasites, and viruses. Lutzomyia apache was incriminated as a vector of vesicular stomatitis viruses(VSV)due to overlapping ranges of the sand fly and outbreaks of VSV. I report on newly discovered populations of L. apache in Wyoming from Albany and ...

  20. 77 FR 51475 - Safety Zone; Apache Pier Labor Day Fireworks; Myrtle Beach, SC

    Science.gov (United States)

    2012-08-24

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Apache Pier Labor Day Fireworks; Myrtle... establishing a temporary safety zone on the waters of the Atlantic Ocean in the vicinity of Apache Pier...

  1. Fort Apache Reservation Manpower Resources; Indian Manpower Resources in the Southwest. A Pilot Study.

    Science.gov (United States)

    Taylor, Benjamin J.; O'Connor, Dennis J.

    Fort Apache Indians live in relative geographic and cultural isolation. The Apaches are younger than the general population, have a lower rate of overall labor-force participation, and typically work for the Federal Government or in trbal enterprises. A median family with 5 children subsists on a median annual family income of less than $1,000.…

  2. A Needs Assessment Study at Apache Junction for Long Range Planning.

    Science.gov (United States)

    Gibson, Dale R.

    As part of an effort to assess the postsecondary educational needs of the community of Apache Junction, surveys were administered to: (1) students in grades 9-12 at Apache Junction High School (N=420) with regard to their educational plans, the postsecondary institutions they anticipated attending, course and program interests of those planning to…

  3. A Photographic Essay of Apache Children in Early Times, Volume 2-Part C.

    Science.gov (United States)

    Thompson, Doris; Jacobs, Ben

    As part of a series of guides designed for instruction of American Indian children and youth, this resource guide constitutes a pictorial essay on life of the Apache child from 1880 to the early 20th century. Each of the 12 photographs is accompanied by an historical narrative which describes one or more cultural aspects of Apache childhood.…

  4. A Photographic Essay of Apache Chiefs and Warriors, Volume 2-Part B.

    Science.gov (United States)

    Barkan, Gerald; Jacobs, Ben

    As part of a series designed for instruction of American Indian children and youth, this resource guide constitutes a pictorial essay describing forts, Indian agents, and Apache chiefs, warriors, and scouts of the 19th century. Accompanying each picture is a brief historical-biographical narrative. Focus is on Apache resistance to the reservation.…

  5. In silico prediction of ROCK II inhibitors by different classification approaches.

    Science.gov (United States)

    Cai, Chuipu; Wu, Qihui; Luo, Yunxia; Ma, Huili; Shen, Jiangang; Zhang, Yongbin; Yang, Lei; Chen, Yunbo; Wen, Zehuai; Wang, Qi

    2017-08-02

    ROCK II is an important pharmacological target linked to central nervous system disorders such as Alzheimer's disease. The purpose of this research is to generate ROCK II inhibitor prediction models by machine learning approaches. Firstly, four sets of descriptors were calculated with MOE 2010 and PaDEL-Descriptor, and optimized by F-score and linear forward selection methods. In addition, four classification algorithms were used to initially build 16 classifiers with k-nearest neighbors [Formula: see text], naïve Bayes, Random forest, and support vector machine. Furthermore, three sets of structural fingerprint descriptors were introduced to enhance the predictive capacity of classifiers, which were assessed with fivefold cross-validation, test set validation and external test set validation. The best two models, MFK + MACCS and MLR + SubFP, have both MCC values of 0.925 for external test set. After that, a privileged substructure analysis was performed to reveal common chemical features of ROCK II inhibitors. Finally, binding modes were analyzed to identify relationships between molecular descriptors and activity, while main interactions were revealed by comparing the docking interaction of the most potent and the weakest ROCK II inhibitors. To the best of our knowledge, this is the first report on ROCK II inhibitors utilizing machine learning approaches that provides a new method for discovering novel ROCK II inhibitors.

  6. Concurrent and Predictive Validity of the Phelps Kindergarten Readiness Scale-II

    Science.gov (United States)

    Duncan, Jennifer; Rafter, Erin M.

    2005-01-01

    The purpose of this research was to establish the concurrent and predictive validity of the Phelps Kindergarten Readiness Scale, Second Edition (PKRS-II; L. Phelps, 2003). Seventy-four kindergarten students of diverse ethnic backgrounds enrolled in a northeastern suburban school participated in the study. The concurrent administration of the…

  7. Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lundegaard, Claus; Worning, Peder;

    2004-01-01

    to the MHC class II complex HLA-DR4(B1*0401). Prior identification of information-rich (anchor) positions in the binding motif is shown to improve the predictive performance of the Gibbs sampler. Similarly, a consensus solution obtained from an ensemble average over suboptimal solutions is shown...

  8. FORUM - FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology

    Science.gov (United States)

    FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo resp...

  9. Support vector regression model for predicting the sorption capacity of lead (II

    Directory of Open Access Journals (Sweden)

    Nusrat Parveen

    2016-09-01

    Full Text Available Biosorption is supposed to be an economical process for the treatment of wastewater containing heavy metals like lead (II. In this research paper, the support vector regression (SVR has been used to predict the sorption capacity of lead (II ions with the independent input parameters being: initial lead ion concentration, pH, temperature and contact time. Tree fern, an agricultural by-product, has been employed as a low cost biosorbent. Comparison between multiple linear regression (MLR and SVR-based models has been made using statistical parameters. It has been found that the SVR model is more accurate and generalized for prediction of the sorption capacity of lead (II ions.

  10. Prediction of the binding affinities of peptides to class II MHC using a regularized thermodynamic model

    Directory of Open Access Journals (Sweden)

    Mittelmann Hans D

    2010-01-01

    Full Text Available Abstract Background The binding of peptide fragments of extracellular peptides to class II MHC is a crucial event in the adaptive immune response. Each MHC allotype generally binds a distinct subset of peptides and the enormous number of possible peptide epitopes prevents their complete experimental characterization. Computational methods can utilize the limited experimental data to predict the binding affinities of peptides to class II MHC. Results We have developed the Regularized Thermodynamic Average, or RTA, method for predicting the affinities of peptides binding to class II MHC. RTA accounts for all possible peptide binding conformations using a thermodynamic average and includes a parameter constraint for regularization to improve accuracy on novel data. RTA was shown to achieve higher accuracy, as measured by AUC, than SMM-align on the same data for all 17 MHC allotypes examined. RTA also gave the highest accuracy on all but three allotypes when compared with results from 9 different prediction methods applied to the same data. In addition, the method correctly predicted the peptide binding register of 17 out of 18 peptide-MHC complexes. Finally, we found that suboptimal peptide binding registers, which are often ignored in other prediction methods, made significant contributions of at least 50% of the total binding energy for approximately 20% of the peptides. Conclusions The RTA method accurately predicts peptide binding affinities to class II MHC and accounts for multiple peptide binding registers while reducing overfitting through regularization. The method has potential applications in vaccine design and in understanding autoimmune disorders. A web server implementing the RTA prediction method is available at http://bordnerlab.org/RTA/.

  11. Fedora Commons With Apache Hadoop: A Research Study

    Directory of Open Access Journals (Sweden)

    Abdul Rasheed

    2013-10-01

    Full Text Available The Digital Collections digital repository at the University of Maryland Libraries is growing and in need of a new backend storage system to replace the current filesystem storage. Though not a traditional storage management system, we chose to evaluate Apache Hadoop because of its large and growing community and software ecosystem. Additionally, Hadoop’s capabilities for distributed computation could prove useful in providing new kinds of digital object services and maintenance for ever increasing amounts of data. We tested storage of Fedora Commons data in the Hadoop Distributed File System (HDFS using an early development version of Akubra-HDFS interface created by Frank Asseg. This article examines the findings of our research study, which evaluated Fedora-Hadoop integration in the areas of performance, ease of access, security, disaster recovery, and costs.

  12. The Impact of EuroSCORE II Risk Factors on Prediction of Long-Term Mortality.

    Science.gov (United States)

    Barili, Fabio; Pacini, Davide; D'Ovidio, Mariangela; Dang, Nicholas C; Alamanni, Francesco; Di Bartolomeo, Roberto; Grossi, Claudio; Davoli, Marina; Fusco, Danilo; Parolari, Alessandro

    2016-10-01

    The European System for Cardiac Operation Risk Evaluation (EuroSCORE) II has not been tested yet for predicting long-term mortality. This study was undertaken to evaluate the relationship between EuroSCORE II and long-term mortality and to develop a new algorithm based on EuroSCORE II factors to predict long-term survival after cardiac surgery. Complete data on 10,033 patients who underwent major cardiac surgery during a 7-year period were retrieved from three prospective institutional databases and linked with the Italian Tax Register Information System. Mortality at follow-up was analyzed with time-to-event analysis. The Kaplan-Meier estimates of survival at 1 and 5 were, respectively, 95.0% ± 0.2% and 84.7% ± 0.4%. Both discrimination and calibration of EuroSCORE II decreased in the prediction of 1-year and 5-year mortality. Nonetheless, EuroSCORE II was confirmed to be an independent predictor of long-term mortality with a nonlinear trend. Several EuroSCORE II variables were independent risk factors for long-term mortality in a regression model, most of all very low ejection fraction (less than 20%), salvage operation, and dialysis. In the final model, isolated mitral valve surgery and isolated coronary artery bypass graft surgery were associated with improved long-term survival. The EuroSCORE II cannot be considered a direct estimator of long-term risk of death, as its performance fades for mortality at follow-up longer than 30 days. Nonetheless, it is nonlinearly associated with long-term mortality, and most of its variables are risk factors for long-term mortality. Hence, they can be used in a different algorithm to stratify the risk of long-term mortality after surgery. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  13. Bayesian Estimation and Prediction for Flexible Weibull Model under Type-II Censoring Scheme

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar Singh

    2013-01-01

    Full Text Available We have developed the Bayesian estimation procedure for flexible Weibull distribution under Type-II censoring scheme assuming Jeffrey's scale invariant (noninformative and Gamma (informative priors for the model parameters. The interval estimation for the model parameters has been performed through normal approximation, bootstrap, and highest posterior density (HPD procedures. Further, we have also derived the predictive posteriors and the corresponding predictive survival functions for the future observations based on Type-II censored data from the flexible Weibull distribution. Since the predictive posteriors are not in the closed form, we proposed to use the Monte Carlo Markov chain (MCMC methods to approximate the posteriors of interest. The performance of the Bayes estimators has also been compared with the classical estimators of the model parameters through the Monte Carlo simulation study. A real data set representing the time between failures of secondary reactor pumps has been analysed for illustration purpose.

  14. Prediction of HLA class II alleles using SNPs in an African population.

    Directory of Open Access Journals (Sweden)

    Fasil Tekola Ayele

    Full Text Available Despite the importance of the human leukocyte antigen (HLA gene locus in research and clinical practice, direct HLA typing is laborious and expensive. Furthermore, the analysis requires specialized software and expertise which are unavailable in most developing country settings. Recently, in silico methods have been developed for predicting HLA alleles using single nucleotide polymorphisms (SNPs. However, the utility of these methods in African populations has not been systematically evaluated.In the present study, we investigate prediction of HLA class II (HLA-DRB1 and HLA-DQB1 alleles using SNPs in the Wolaita population, southern Ethiopia. The subjects comprised 297 Ethiopians with genome-wide SNP data, of whom 188 had also been HLA typed and were used for training and testing the model. The 109 subjects with SNP data alone were used for empirical prediction using the multi-allelic gene prediction method. We evaluated accuracy of the prediction, agreement between predicted and HLA typed alleles, and discriminative ability of the prediction probability supplied by the model. We found that the model predicted intermediate (two-digit resolution for HLA-DRB1 and HLA-DQB1 alleles at accuracy levels of 96% and 87%, respectively. All measures of performance showed high accuracy and reliability for prediction. The distribution of the majority of HLA alleles in the study was similar to that previously reported for the Oromo and Amhara ethnic groups from Ethiopia.We demonstrate that HLA class II alleles can be predicted from SNP genotype data with a high level of accuracy at intermediate (two-digit resolution in an African population. This finding offers new opportunities for HLA studies of disease epidemiology and population genetics in developing countries.

  15. 大数据处理模型Apache Spark研究%Research on Apache Spark for Big Data Processing

    Institute of Scientific and Technical Information of China (English)

    黎文阳

    2015-01-01

    Apache Spark是当前流行的大数据处理模型,具有快速、通用、简单等特点。Spark是针对MapReduce在迭代式机器学习算法和交互式数据挖掘等应用方面的低效率,而提出的新的内存计算框架,既保留了MapReduce的可扩展性、容错性、兼容性,又弥补了MapReduce在这些应用上的不足。由于采用基于内存的集群计算,所以Spark在这些应用上比MapReduce快100倍。介绍Spark的基本概念、组成部分、部署模式,分析Spark的核心内容与编程模型,给出相关的编程示例。%Apache Spark is a popular model for large scale data processing at present, which is fast, general and easy. Compared with the MapRe-duce computing framework, Spark is efficient in iterative machine learning algorithms and interactive data mining applications while re-taining the compatibility, scalability and fault-tolerance of MapReduce. With its in-memory computing, Spark is up to 100x faster than Hadoop MapReduce in memory. Presents the basic conception, component and the deploying mode of Spark, introduces the internal ab-straction and the programming model, gives the programming examples.

  16. HART-II Acoustic Predictions using a Coupled CFD/CSD Method

    Science.gov (United States)

    Boyd, D. Douglas, Jr.

    2009-01-01

    This paper documents results to date from the Rotorcraft Acoustic Characterization and Mitigation activity under the NASA Subsonic Rotary Wing Project. The primary goal of this activity is to develop a NASA rotorcraft impulsive noise prediction capability which uses first principles fluid dynamics and structural dynamics. During this effort, elastic blade motion and co-processing capabilities have been included in a recent version of the computational fluid dynamics code (CFD). The CFD code is loosely coupled to computational structural dynamics (CSD) code using new interface codes. The CFD/CSD coupled solution is then used to compute impulsive noise on a plane under the rotor using the Ffowcs Williams-Hawkings solver. This code system is then applied to a range of cases from the Higher Harmonic Aeroacoustic Rotor Test II (HART-II) experiment. For all cases presented, the full experimental configuration (i.e., rotor and wind tunnel sting mount) are used in the coupled CFD/CSD solutions. Results show good correlation between measured and predicted loading and loading time derivative at the only measured radial station. A contributing factor for a typically seen loading mean-value offset between measured data and predictions data is examined. Impulsive noise predictions on the measured microphone plane under the rotor compare favorably with measured mid-frequency noise for all cases. Flow visualization of the BL and MN cases shows that vortex structures generated in the prediction method are consist with measurements. Future application of the prediction method is discussed.

  17. The ARIC predictive model reliably predicted risk of type II diabetes in Asian populations

    Directory of Open Access Journals (Sweden)

    Chin Calvin

    2012-04-01

    Full Text Available Abstract Background Identification of high-risk individuals is crucial for effective implementation of type 2 diabetes mellitus prevention programs. Several studies have shown that multivariable predictive functions perform as well as the 2-hour post-challenge glucose in identifying these high-risk individuals. The performance of these functions in Asian populations, where the rise in prevalence of type 2 diabetes mellitus is expected to be the greatest in the next several decades, is relatively unknown. Methods Using data from three Asian populations in Singapore, we compared the performance of three multivariate predictive models in terms of their discriminatory power and calibration quality: the San Antonio Health Study model, Atherosclerosis Risk in Communities model and the Framingham model. Results The San Antonio Health Study and Atherosclerosis Risk in Communities models had better discriminative powers than using only fasting plasma glucose or the 2-hour post-challenge glucose. However, the Framingham model did not perform significantly better than fasting glucose or the 2-hour post-challenge glucose. All published models suffered from poor calibration. After recalibration, the Atherosclerosis Risk in Communities model achieved good calibration, the San Antonio Health Study model showed a significant lack of fit in females and the Framingham model showed a significant lack of fit in both females and males. Conclusions We conclude that adoption of the ARIC model for Asian populations is feasible and highly recommended when local prospective data is unavailable.

  18. Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms

    Directory of Open Access Journals (Sweden)

    Feng Lin

    2007-11-01

    Full Text Available Abstract Background Peptides binding to Major Histocompatibility Complex (MHC class II molecules are crucial for initiation and regulation of immune responses. Predicting peptides that bind to a specific MHC molecule plays an important role in determining potential candidates for vaccines. The binding groove in class II MHC is open at both ends, allowing peptides longer than 9-mer to bind. Finding the consensus motif facilitating the binding of peptides to a MHC class II molecule is difficult because of different lengths of binding peptides and varying location of 9-mer binding core. The level of difficulty increases when the molecule is promiscuous and binds to a large number of low affinity peptides. In this paper, we propose two approaches using multi-objective evolutionary algorithms (MOEA for predicting peptides binding to MHC class II molecules. One uses the information from both binders and non-binders for self-discovery of motifs. The other, in addition, uses information from experimentally determined motifs for guided-discovery of motifs. Results The proposed methods are intended for finding peptides binding to MHC class II I-Ag7 molecule – a promiscuous binder to a large number of low affinity peptides. Cross-validation results across experiments on two motifs derived for I-Ag7 datasets demonstrate better generalization abilities and accuracies of the present method over earlier approaches. Further, the proposed method was validated and compared on two publicly available benchmark datasets: (1 an ensemble of qualitative HLA-DRB1*0401 peptide data obtained from five different sources, and (2 quantitative peptide data obtained for sixteen different alleles comprising of three mouse alleles and thirteen HLA alleles. The proposed method outperformed earlier methods on most datasets, indicating that it is well suited for finding peptides binding to MHC class II molecules. Conclusion We present two MOEA-based algorithms for finding motifs

  19. Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes

    DEFF Research Database (Denmark)

    Christiansen, Merete S; Hommel, E; Magid, E

    2002-01-01

    AIMS/HYPOTHESIS: Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate. The aim of this study was to determine whether increased urinary orosomucoid excretion rate...... is predictive of increased mortality in patients with Type II diabetes. METHODS: In a cohort study including 430 patients with Type II diabetes, baseline urinary samples were analysed for orosomucoid and albumin. Mean follow-up was 2.4 years. RESULTS: We found that 188 (44 %) patients had normal and 242 (56...... urinary orosomucoid excretion rate was not included in the analysis. Subgroup analysis revealed that 39 % of the patients with normal urinary albumin excretion rate (n = 251) had increased urinary orosomucoid excretion rates and that these patients had a higher cardiovascular mortality (p = 0.007) than...

  20. MOND Prediction for the Velocity Dispersion of the `Feeble Giant' Crater II

    CERN Document Server

    McGaugh, Stacy S

    2016-01-01

    Crater II is an unusual object among the dwarf satellite galaxies of the Local Group in that it has a very large size for its small luminosity. This provides a strong test of MOND, as Crater II should be in the deep MOND regime ($g_{in} \\approx 34\\;\\mathrm{km}^2\\,\\mathrm{s}^{-2}\\,\\mathrm{kpc}^{-1} \\ll a_0 = 3700\\;\\mathrm{km}^2\\,\\mathrm{s}^{-2}\\,\\mathrm{kpc}^{-1}$). Despite its great distance ($\\approx 120$ kpc) from the Milky Way, the external field of the host ($g_{ex} \\approx 282\\; \\mathrm{km}^2\\,\\mathrm{s}^{-2}\\,\\mathrm{kpc}^{-1}$) comfortably exceeds the internal field. Consequently, Crater II should be subject to the external field effect, a feature unique to MOND. This leads to the prediction of a very low velocity dispersion: $\\sigma_{efe} = 2.1^{+0.9}_{-0.6}\\;\\mathrm{km}\\,\\mathrm{s}^{-1}$.

  1. Prediction of RNA Polymerase II recruitment, elongation and stalling from histone modification data

    DEFF Research Database (Denmark)

    Chen, Yun; Jørgensen, Mette; Kolde, Raivo;

    2011-01-01

    ABSTRACT: BACKGROUND: Initiation and elongation of RNA polymerase II (RNAPII) transcription is regulated by both DNA sequence and chromatin signals. Recent breakthroughs make it possible to measure the chromatin state and activity of core promoters genome-wide, but dedicated computational...... that are the most influential for prediction, it can be used to infer underlying regulatory biology. For example, we show that the H3K4 di- and tri- methylation signals are strongly predictive for promoter location while the acetylation marks H3K9 and H3K27 are highly important in estimating the promoter usage. All...

  2. The Trail Inventory of Bosque Del Apache National Wildlife Refuge [Cycle 1

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The purpose of this report is to create a baseline inventory of all non-motorized trails on Bosque Del Apache National Wildlife Refuge. Trails in this inventory are...

  3. Analyzing large data sets from XGC1 magnetic fusion simulations using apache spark

    Energy Technology Data Exchange (ETDEWEB)

    Churchill, R. Michael [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States)

    2016-11-21

    Apache Spark is explored as a tool for analyzing large data sets from the magnetic fusion simulation code XGCI. Implementation details of Apache Spark on the NERSC Edison supercomputer are discussed, including binary file reading, and parameter setup. Here, an unsupervised machine learning algorithm, k-means clustering, is applied to XGCI particle distribution function data, showing that highly turbulent spatial regions do not have common coherent structures, but rather broad, ring-like structures in velocity space.

  4. 浅析中文环境下的Apach Commons HttpClient编程

    Institute of Scientific and Technical Information of China (English)

    洪亮; 田支斌

    2008-01-01

    本文详尽的分析了在中文环境下运用Apach Commons HttpClient进行编程时出现的几个常见问题。针对每个问题.本文均给出较为完善的解决方案,对中文环境下的Apach Commons HttpClient编程具有极大的现实参考价值。

  5. Critical Technology Events in the Development of the Apache Helicopter. Project Hindsight Revisited

    Science.gov (United States)

    2006-02-01

    weapons systems also benefited the Apache. Among these advances were a common module approach to FLIR production and a minimum resolvable temperature ( MRT ...determination as a way to measure FLIR performance. Also, it should be noted that for the Apache, with the work on the MRT as a foundation, the U.S...Industry’s creative work on the T700 series of helicopter engines is an example. 3. The Army experiences with helicopters in Vietnam had a strong

  6. The Apache Point Observatory Galactic Evolution Experiment (APOGEE)

    CERN Document Server

    Majewski, Steven R; Frinchaboy, Peter M; Prieto, Carlos Allende; Barkhouser, Robert; Bizyaev, Dmitry; Blank, Basil; Brunner, Sophia; Burton, Adam; Carrera, Ricardo; Chojnowski, S Drew; Cunha, Katia; Epstein, Courtney; Fitzgerald, Greg; Perez, Ana E Garcia; Hearty, Fred R; Henderson, Chuck; Holtzman, Jon A; Johnson, Jennifer A; Lam, Charles R; Lawler, James E; Maseman, Paul; Meszaros, Szabolcs; Nelson, Matthew; Nguyen, Duy Coung; Nidever, David L; Pinsonneault, Marc; Shetrone, Matthew; Smee, Stephen; Smith, Verne V; Stolberg, Todd; Skrutskie, Michael F; Walker, Eric; Wilson, John C; Zasowski, Gail; Anders, Friedrich; Basu, Sarbani; Beland, Stephane; Blanton, Michael R; Bovy, Jo; Brownstein, Joel R; Carlberg, Joleen; Chaplin, William; Chiappini, Cristina; Eisenstein, Daniel J; Elsworth, Yvonne; Feuillet, Diane; Fleming, Scott W; Galbraith-Frew, Jessica; Garcia, Rafael A; Garcia-Hernandez, D Anibal; Gillespie, Bruce A; Girardi, Leo; Gunn, James E; Hasselquist, Sten; Hayden, Michael R; Hekker, Saskia; Ivans, Inese; Kinemuchi, Karen; Klaene, Mark; Mahadevan, Suvrath; Mathur, Savita; Mosser, Benoit; Muna, Demitri; Munn, Jeffrey A; Nichol, Robert C; O'Connell, Robert W; Robin, A C; Rocha-Pinto, Helio; Schultheis, Matthias; Serenelli, Aldo M; Shane, Neville; Aguirre, Victor Silva; Sobeck, Jennifer S; Thompson, Benjamin; Troup, Nicholas W; Weinberg, David H; Zamora, Olga

    2015-01-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE), one of the programs in the Sloan Digital Sky Survey III (SDSS-III), has now completed its systematic, homogeneous spectroscopic survey sampling all major populations of the Milky Way. After a three year observing campaign on the Sloan 2.5-m Telescope, APOGEE has collected a half million high resolution (R~22,500), high S/N (>100), infrared (1.51-1.70 microns) spectra for 146,000 stars, with time series information via repeat visits to most of these stars. This paper describes the motivations for the survey and its overall design---hardware, field placement, target selection, operations---and gives an overview of these aspects as well as the data reduction, analysis and products. An index is also given to the complement of technical papers that describe various critical survey components in detail. Finally, we discuss the achieved survey performance and illustrate the variety of potential uses of the data products by way of a number of scienc...

  7. Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients

    DEFF Research Database (Denmark)

    Urup, Thomas; Michaelsen, Signe Regner; Olsen, Lars Rønn

    2016-01-01

    Background: Bevacizumab combination therapy is among the most frequently used treatments in recurrent glioblastoma and patients who achieve response to bevacizumab have improved survival as well as quality of life. Accordingly, the aim of this study was to identify predictive biomarkers...... for bevacizumab response in recurrent glioblastoma patients. Methods: The study included a total of 82 recurrent glioblastoma patients treated with bevacizumab combination therapy whom were both response and biomarker evaluable. Gene expression of tumor tissue was analyzed by using a customized Nano.......0009) and high expression of a HLA class II gene (2-fold increase in HLA-DQA1; OR = 1.22; 95% CI: 1.01-1.47; P = 0.04). These two genes were included in a model that is able predict response to bevacizumab combination therapy in clinical practice. When stratified for a validated prognostic index, the predictive...

  8. Tree-Based Models for Predicting Mortality in Gram-Negative Bacteremia: Avoid Putting the CART before the Horse

    Science.gov (United States)

    O'Donnell, J. Nicholas; Lizza, Bryan D.; McLaughlin, Milena M.; Esterly, John S.

    2015-01-01

    Increasingly, infectious disease studies employ tree-based approaches, e.g., classification and regression tree modeling, to identify clinical thresholds. We present tree-based-model-derived thresholds along with their measures of uncertainty. We explored individual and pooled clinical cohorts of bacteremic patients to identify modified acute physiology and chronic health evaluation (II) (m-APACHE-II) score mortality thresholds using a tree-based approach. Predictive performance measures for each candidate threshold were calculated. Candidate thresholds were examined according to binary logistic regression probabilities of the primary outcome, correct classification predictive matrices, and receiver operating characteristic curves. Three individual cohorts comprising a total of 235 patients were studied. Within the pooled cohort, the mean (± standard deviation) m-APACHE-II score was 13.6 ± 5.3, with an in-hospital mortality of 16.6%. The probability of death was greater at higher m-APACHE II scores in only one of three cohorts (odds ratio for cohort 1 [OR1] = 1.15, 95% confidence interval [CI] = 0.99 to 1.34; OR2 = 1.04, 95% CI = 0.94 to 1.16; OR3 = 1.18, 95% CI = 1.02 to 1.38) and was greater at higher scores within the pooled cohort (OR4 = 1.11, 95% CI = 1.04 to 1.19). In contrast, tree-based models overcame power constraints and identified m-APACHE-II thresholds for mortality in two of three cohorts (P = 0.02, 0.1, and 0.008) and the pooled cohort (P = 0.001). Predictive performance at each threshold was highly variable among cohorts. The selection of any one predictive threshold value resulted in fixed sensitivity and specificity. Tree-based models increased power and identified threshold values from continuous predictor variables; however, sample size and data distributions influenced the identified thresholds. The provision of predictive matrices or graphical displays of predicted probabilities within infectious disease studies can improve the

  9. Redskins in Bluecoats: A Strategic and Cultural Analysis of General George Crooks Use of Apache Scouts in the Second Apache Campaign, 1882-1886

    Science.gov (United States)

    2010-03-31

    many of the Apaches were to be seen ... All the young men who could shoot were hiding in the mountains ... among all people whose opinion was...at the operational level of ar, and his subordinate officers Cra ford and ate ood operating at the tactical level of ar. The sa e could not be said

  10. The Apache Point Observatory Galactic Evolution Experiment (APOGEE)

    Science.gov (United States)

    Majewski, Steven R.; Schiavon, Ricardo P.; Frinchaboy, Peter M.; Allende Prieto, Carlos; Barkhouser, Robert; Bizyaev, Dmitry; Blank, Basil; Brunner, Sophia; Burton, Adam; Carrera, Ricardo; Chojnowski, S. Drew; Cunha, Kátia; Epstein, Courtney; Fitzgerald, Greg; García Pérez, Ana E.; Hearty, Fred R.; Henderson, Chuck; Holtzman, Jon A.; Johnson, Jennifer A.; Lam, Charles R.; Lawler, James E.; Maseman, Paul; Mészáros, Szabolcs; Nelson, Matthew; Nguyen, Duy Coung; Nidever, David L.; Pinsonneault, Marc; Shetrone, Matthew; Smee, Stephen; Smith, Verne V.; Stolberg, Todd; Skrutskie, Michael F.; Walker, Eric; Wilson, John C.; Zasowski, Gail; Anders, Friedrich; Basu, Sarbani; Beland, Stephane; Blanton, Michael R.; Bovy, Jo; Brownstein, Joel R.; Carlberg, Joleen; Chaplin, William; Chiappini, Cristina; Eisenstein, Daniel J.; Elsworth, Yvonne; Feuillet, Diane; Fleming, Scott W.; Galbraith-Frew, Jessica; García, Rafael A.; García-Hernández, D. Aníbal; Gillespie, Bruce A.; Girardi, Léo; Gunn, James E.; Hasselquist, Sten; Hayden, Michael R.; Hekker, Saskia; Ivans, Inese; Kinemuchi, Karen; Klaene, Mark; Mahadevan, Suvrath; Mathur, Savita; Mosser, Benoît; Muna, Demitri; Munn, Jeffrey A.; Nichol, Robert C.; O'Connell, Robert W.; Parejko, John K.; Robin, A. C.; Rocha-Pinto, Helio; Schultheis, Matthias; Serenelli, Aldo M.; Shane, Neville; Silva Aguirre, Victor; Sobeck, Jennifer S.; Thompson, Benjamin; Troup, Nicholas W.; Weinberg, David H.; Zamora, Olga

    2017-09-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE), one of the programs in the Sloan Digital Sky Survey III (SDSS-III), has now completed its systematic, homogeneous spectroscopic survey sampling all major populations of the Milky Way. After a three-year observing campaign on the Sloan 2.5 m Telescope, APOGEE has collected a half million high-resolution (R ˜ 22,500), high signal-to-noise ratio (>100), infrared (1.51-1.70 μm) spectra for 146,000 stars, with time series information via repeat visits to most of these stars. This paper describes the motivations for the survey and its overall design—hardware, field placement, target selection, operations—and gives an overview of these aspects as well as the data reduction, analysis, and products. An index is also given to the complement of technical papers that describe various critical survey components in detail. Finally, we discuss the achieved survey performance and illustrate the variety of potential uses of the data products by way of a number of science demonstrations, which span from time series analysis of stellar spectral variations and radial velocity variations from stellar companions, to spatial maps of kinematics, metallicity, and abundance patterns across the Galaxy and as a function of age, to new views of the interstellar medium, the chemistry of star clusters, and the discovery of rare stellar species. As part of SDSS-III Data Release 12 and later releases, all of the APOGEE data products are publicly available.

  11. Echelle spectra of SN2014J from the Apache Point Observatory 3.5m telescope, UT January 27 and January 30, 2014

    Science.gov (United States)

    Ritchey, Adam M.; Welty, Daniel E.; Dahlstrom, Julie A.; York, Donald G.

    2014-02-01

    Optical spectra of SN2014J were recorded with the ARC echelle spectrograph at Apache Point Observatory, at approximately UT Jan. 27.2 (7 spectra, 8400 s) and UT Jan. 30.4, (6 spectra, 7200s), through thin clouds in seeing averaging 1.0 arcsec. The resolving power is 31,500. Useful interstellar spectra were obtained from 3850A to 9000A; estimated S/N values (photon counts only) near 6563A are 500 on Jan 27 and 400 on Jan 30, and about 1/3 those values at Ca II 3933A.

  12. Outcome prediction in a surgical ICU using automatically calculated SAPS II scores.

    Science.gov (United States)

    Engel, J M; Junger, A; Bottger, S; Benson, M; Michel, A; Rohrig, R; Jost, A; Hempelmann, G

    2003-10-01

    The objective of this study was to establish a complete computerized calculation of the Simplified Acute Physiology Score (SAPS) II within 24 hours after admission to a surgical intensive care unit (ICU) based only on routine data recorded with a patient data management system (PDMS) without any additional manual data entry. Score calculation programs were developed using SQL scripts (Structured Query Language) to retrospectively compute the SAPS II scores of 524 patients who stayed in ICU for at least 24 hours between April 1, 1999 and March 31, 2000 out of the PDMS database. The main outcome measure was survival status at ICU discharge. Score evaluation was modified in registering missing data as being not pathological and using surrogates of the Glasgow Coma Scale (GCS). Computerized score calculation was possible for all investigated patients. The 459 (87.6%) survivors had a median SAPS II of 28 (interquartile range (IQR) 13) whereas the 65 (12.4%) decreased patients had a median score of 43 (IQR 16; P calculation, bilirubin was missing in 84%, followed by PaO2/FiO2 ratio (34%), and neurological status (34%). Using neurological diagnoses and examinations as surrogates for the GCS, a pathological finding was seen in only 8.8% of all results. The discriminative power of the computerized SAPS II checked with a receiver operating characteristic (ROC) curve was 0.81 (95% confidence interval (CI): 0.74-0.87). The Hosmer-Lemeshow goodness-of-fit statistics showed good calibration (H = 5.55, P = 0.59, 7 degrees of freedom; C = 5.55, P = 0.68, 8 degrees of freedom). The technique used in this study for complete automatic data sampling of the SAPS II score seems to be suitable for predicting mortality rate during stay in a surgical ICU. The advantage of the described method is that no additional manual data recording is required for score calculation.

  13. Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome

    Directory of Open Access Journals (Sweden)

    Ling Tang

    2014-01-01

    Full Text Available Purpose. To investigate the prognostic significance of endocan, compared with procalcitonin (PCT, C-reactive protein (CRP,white blood cells (WBC, neutrophils (N, and clinical severity scores in patients with ARDS. Methods. A total of 42 patients with ARDS were initially enrolled, and there were 20 nonsurvivors and 22 survivors based on hospital mortality. Plasma levels of biomarkers were measured and the acute physiology and chronic health evaluation II (APACHE II was calculated on day 1 after the patient met the defining criteria of ARDS. Results. Endocan levels significantly correlated with the APACHE II score in the ARDS group (r=0.676, P=0.000, n=42. Of 42 individuals with ARDS, 20 were dead, and endocan was significantly higher in nonsurvivors than in survivors (median (IQR 5.01 (2.98–8.44 versus 3.01 (2.36–4.36 ng/mL, P=0.017. According to the results of the ROC-curve analysis and COX proportional hazards models, endocan can predict mortality of ARDS independently with a hazard ratio of 1.374 (95% CI, 1.150–1.641 and an area of receiver operator characteristic curve (AUROC of 0.715 (P=0.017. Moreover, endocan can predict the multiple-organ dysfunction of ARDS. Conclusion. Endocan is a promising biomarker to predict the disease severity and mortality in patients with ARDS.

  14. A Tour of Big Data, Open Source Data Management Technologies from the Apache Software Foundation

    Science.gov (United States)

    Mattmann, C. A.

    2012-12-01

    The Apache Software Foundation, a non-profit foundation charged with dissemination of open source software for the public good, provides a suite of data management technologies for distributed archiving, data ingestion, data dissemination, processing, triage and a host of other functionalities that are becoming critical in the Big Data regime. Apache is the world's largest open source software organization, boasting over 3000 developers from around the world all contributing to some of the most pervasive technologies in use today, from the HTTPD web server that powers a majority of Internet web sites to the Hadoop technology that is now projected at over a $1B dollar industry. Apache data management technologies are emerging as de facto off-the-shelf components for searching, distributing, processing and archiving key science data sets both geophysical, space and planetary based, all the way to biomedicine. In this talk, I will give a virtual tour of the Apache Software Foundation, its meritocracy and governance structure, and also its key big data technologies that organizations can take advantage of today and use to save cost, schedule, and resources in implementing their Big Data needs. I'll illustrate the Apache technologies in the context of several national priority projects, including the U.S. National Climate Assessment (NCA), and in the International Square Kilometre Array (SKA) project that are stretching the boundaries of volume, velocity, complexity, and other key Big Data dimensions.

  15. Gate-tunable negative longitudinal magnetoresistance in the predicted type-II Weyl semimetal WTe2

    Science.gov (United States)

    Wang, Yaojia; Liu, Erfu; Liu, Huimei; Pan, Yiming; Zhang, Longqiang; Zeng, Junwen; Fu, Yajun; Wang, Miao; Xu, Kang; Huang, Zhong; Wang, Zhenlin; Lu, Hai-Zhou; Xing, Dingyu; Wang, Baigeng; Wan, Xiangang; Miao, Feng

    2016-10-01

    The progress in exploiting new electronic materials has been a major driving force in solid-state physics. As a new state of matter, a Weyl semimetal (WSM), in particular a type-II WSM, hosts Weyl fermions as emergent quasiparticles and may harbour novel electrical transport properties. Nevertheless, such a type-II WSM material has not been experimentally observed. In this work, by performing systematic magneto-transport studies on thin films of a predicted material candidate WTe2, we observe notable negative longitudinal magnetoresistance, which can be attributed to the chiral anomaly in WSM. This phenomenon also exhibits strong planar orientation dependence with the absence along the tungsten chains, consistent with the distinctive feature of a type-II WSM. By applying a gate voltage, we demonstrate that the Fermi energy can be in-situ tuned through the Weyl points via the electric field effect. Our results may open opportunities for implementing new electronic applications, such as field-effect chiral devices.

  16. A Model of Biocomplexity in River Networks - Part II: Tenets and Predictions

    Science.gov (United States)

    Delong, M. D.; Thorp, J. H.; Thoms, M. C.

    2005-05-01

    We are proposing a model of lotic biocomplexity encompassing spatiotemporal scales from headwaters to large rivers and from main channels to floodplains. Part I of our presentation in the symposium discusses the general theory and predicted changes along longitudinal gradients in the river network. In Part II, we use the foundation of this theory to make predictions for the ecological behavior of the river ecosystem. These predictions are designed to stimulate research tests of these hypotheses and to obtain data allowing the continuing refinement of the overall model. Fourteen principles or model tenets are included which describe the functioning of epigean portions of lotic ecosystems on ecological time scales; they are focused more on the riverscape than the entire riverine landscape. These 14 tenets predict how patterns of individual species distributions, community regulation, lotic ecosystem processes, and floodplain interactions will vary over spatiotemporal scales, especially as they relate to the functional process zones formed by hydrogeomorphic patches. We make no claim to originality for all these tenets. Some of these ideas are well supported in the scientific literature, others may be acceptable to the scientific community but currently lack empirical support, and some may be very speculative and possibly controversial.

  17. Prediction of positive food effect: Bioavailability enhancement of BCS class II drugs.

    Science.gov (United States)

    Raman, Siddarth; Polli, James E

    2016-06-15

    High-throughput screening methods have increased the number of poorly water-soluble, highly permeable drug candidates. Many of these candidates have increased bioavailability when administered with food (i.e., exhibit a positive food effect). Food is known to impact drug bioavailability through a variety of mechanisms, including drug solubilization and prolonged gastric residence time. In vitro dissolution media that aim to mimic in vivo gastrointestinal (GI) conditions have been developed to lessen the need for fed human bioequivalence studies. The objective of this work was to develop an in vitro lipolysis model to predict positive food effect of three BCS Class II drugs (i.e., danazol, amiodarone and ivermectin) in previously developed lipolysis media. This in vitro lipolysis model was comparatively benchmarked against FeSSIF and FaSSIF media that were modified for an in vitro lipolysis approach, as FeSSIF and FaSSIF are widely used in in vitro dissolution studies. The in vitro lipolysis model accurately predicted the in vivo positive food effect for three model BCS class II drugs. The in vitro lipolysis model has potential use as a screening test of drug candidates in early development to assess positive food effect.

  18. ECG marker of adverse electrical remodeling post-myocardial infarction predicts outcomes in MADIT II study.

    Directory of Open Access Journals (Sweden)

    Larisa G Tereshchenko

    Full Text Available BACKGROUND: Post-myocardial infarction (MI structural remodeling is characterized by left ventricular dilatation, fibrosis, and hypertrophy of the non-infarcted myocardium. OBJECTIVE: The goal of our study was to quantify post-MI electrical remodeling by measuring the sum absolute QRST integral (SAI QRST. We hypothesized that adverse electrical remodeling predicts outcomes in MADIT II study participants. METHODS: Baseline orthogonal ECGs of 750 MADIT II study participants (448 [59.7%] ICD arm were analyzed. SAI QRST was measured as the arithmetic sum of absolute QRST integrals over all three orthogonal ECG leads. The primary endpoint was defined as sudden cardiac death (SCD or sustained ventricular tachycardia (VT/ventricular fibrillation (VF with appropriate ICD therapies. All-cause mortality served as a secondary endpoint. RESULTS: Adverse electrical remodeling in post-MI patients was characterized by wide QRS, increased magnitudes of spatial QRS and T vectors, J-point deviation, and QTc prolongation. In multivariable Cox regression analysis after adjustment for age, QRS duration, atrial fibrillation, New York Heart Association heart failure class and blood urea nitrogen, SAI QRST predicted SCD/VT/VF (HR 1.33 per 100 mV*ms (95%CI 1.11-1.59; P = 0.002, and all-cause death (HR 1.27 per 100 mV*ms (95%CI 1.03-1.55, P = 0.022 in both arms. No interaction with therapy arm and bundle branch block (BBB status was found. CONCLUSIONS: In MADIT II patients, increased SAI QRST is associated with increased risk of sustained VT/VF with appropriate ICD therapies and all-cause death in both ICD and in conventional medical therapy arms, and in patients with and without BBB. Further studies of SAI QRST are warranted.

  19. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lund, Ole

    2009-01-01

    through presentation of extracellularly derived peptides to helper T cells. Identification of which peptides will bind a given MHC molecule is thus of great importance for the understanding of host-pathogen interactions, and large efforts have been placed in developing algorithms capable of predicting...... this binding event. RESULTS: Here, we present a novel artificial neural network-based method, NN-align that allows for simultaneous identification of the MHC class II binding core and binding affinity. NN-align is trained using a novel training algorithm that allows for correction of bias in the training data...... class II alleles, and is demonstrated to outperform other state-of-the-art MHC class II prediction methods. CONCLUSION: The NN-align method is competitive with the state-of-the-art MHC class II peptide binding prediction algorithms. The method is publicly available at http...

  20. Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

    DEFF Research Database (Denmark)

    Nielsen, Morten; Lundegaard, Claus; Lund, Ole

    2007-01-01

    the correct alignment of a peptide in the binding groove a crucial part of identifying the core of an MHC class II binding motif. Here, we present a novel stabilization matrix alignment method, SMM-align, that allows for direct prediction of peptide:MHC binding affinities. The predictive performance...

  1. Jicarilla Apache Utility Authority Renewable Energy and Energy Efficiency Strategic Planning

    Energy Technology Data Exchange (ETDEWEB)

    Rabago, K.R.

    2008-06-28

    The purpose of this Strategic Plan Report is to provide an introduction and in-depth analysis of the issues and opportunities, resources, and technologies of energy efficiency and renewable energy that have potential beneficial application for the people of the Jicarilla Apache Nation and surrounding communities. The Report seeks to draw on the best available information that existed at the time of writing, and where necessary, draws on new research to assess this potential. This study provides a strategic assessment of opportunities for maximizing the potential for electrical energy efficiency and renewable energy development by the Jicarilla Apache Nation. The report analyzes electricity use on the Jicarilla Apache Reservation in buildings. The report also assesses particular resources and technologies in detail, including energy efficiency, solar, wind, geothermal, biomass, and small hydropower. The closing sections set out the elements of a multi-year, multi-phase strategy for development of resources to the maximum benefit of the Nation.

  2. Kelayakan Raspberry Pi sebagai Web Server: Perbandingan Kinerja Nginx, Apache, dan Lighttpd pada Platform Raspberry Pi

    Directory of Open Access Journals (Sweden)

    Rahmad Dawood

    2014-04-01

    Full Text Available Raspberry Pi is a small-sized computer, but it can function like an ordinary computer. Because it can function like a regular PC then it is also possible to run a web server application on the Raspberry Pi. This paper will report results from testing the feasibility and performance of running a web server on the Raspberry Pi. The test was conducted on the current top three most popular web servers, which are: Apache, Nginx, and Lighttpd. The parameters used to evaluate the feasibility and performance of these web servers were: maximum request and reply time. The results from the test showed that it is feasible to run all three web servers on the Raspberry Pi but Nginx gave the best performance followed by Lighttpd and Apache.Keywords: Raspberry Pi, web server, Apache, Lighttpd, Nginx, web server performance

  3. Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Nonsynonymous single nucleotide polymorphisms (nsSNPs) in coding regions can lead to amino acid changes that might alter the protein’s function and account for susceptibility to disease and altered drug/xenobiotic response. Many nsSNPs have been found in genes encoding human phase II metabolizing enzymes; however, there is little known about the relationship between the genotype and phenotype of nsSNPs in these enzymes. We have identified 923 validated nsSNPs in 104 human phase II enzyme genes from the Ensembl genome database and the NCBI SNP database. Using PolyPhen, Panther, and SNAP algorithms, 44%?59% of nsSNPs in phase II enzyme genes were predicted to have functional impacts on protein function. Predictions largely agree with the available experimental annotations. 68% of deleterious nsSNPs were correctly predicted as damaging. This study also identified many amino acids that are likely to be functionally critical, but have not yet been studied experimentally. There was significant concordance between the predicted results of Panther and PolyPhen, and between SNAP non-neutral predictions and PolyPhen scores. Evolutionarily non-neutral (destabilizing) amino acid substitutions are thought to be the pathogenetic basis for the alteration of phase II enzyme activity and to be associated with disease susceptibility and drug/xenobiotic toxicity. Furthermore, the molecular evolutionary patterns of phase II enzymes were characterized with regards to the predicted deleterious nsSNPs.

  4. Value of APACH Ⅱ score combined with procalcitonin detection application in patients with severe Pneumonia%APACH Ⅱ评分及降钙素原联合应用于重症肺炎患者的价值

    Institute of Scientific and Technical Information of China (English)

    江利东

    2013-01-01

    目的 探讨APACHE Ⅱ评分及降钙素原(PCT)动态监测重症肺炎患者的价值.方法 对入住我院ICU的重症肺炎患者共215例进行APACHE Ⅱ评分及PCT的动态监测,比较死亡组和存活组APACHE II评分及PCT数值的关系.结果 患者进入ICU第1天死亡组和存活组PCT检测结果及APACHE Ⅱ评分比较差异无统计学意义.此后存活组PCT检测结果及APACHE Ⅱ评分开始明显下降,直至治疗结束前均呈下降趋势,而死亡组PCT检测结果及APACHE Ⅱ评分较之前明显升高,而且呈逐渐上升趋势,两组比较差异有统计学意义(P<0.05).结论 动态监测APACH Ⅱ评分与PCT结果成正相关,APACH Ⅱ评分与PCT数值越高,病情就越重,死亡率也越高.

  5. FutureTox II: in vitro data and in silico models for predictive toxicology.

    Science.gov (United States)

    Knudsen, Thomas B; Keller, Douglas A; Sander, Miriam; Carney, Edward W; Doerrer, Nancy G; Eaton, David L; Fitzpatrick, Suzanne Compton; Hastings, Kenneth L; Mendrick, Donna L; Tice, Raymond R; Watkins, Paul B; Whelan, Maurice

    2015-02-01

    FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology.

  6. APOLLO: the Apache Point Observatory Lunar Laser-ranging Operation: Instrument Description and First Detections

    CERN Document Server

    Murphy, T W Jr; Battat, J B R; Carey, L N; Hoyle, C D; LeBlanc, P; Michelsen, E L; Nordtvedt, K; Orin, A E; Strasburg, J D; Stubbs, C W; Swanson, H E; Williams, E

    2007-01-01

    A next-generation lunar laser ranging apparatus using the 3.5 m telescope at the Apache Point Observatory in southern New Mexico has begun science operation. APOLLO (the Apache Point Observatory Lunar Laser-ranging Operation) has achieved one-millimeter range precision to the moon which should lead to approximately one-order-of-magnitude improvements in the precision of several tests of fundamental properties of gravity. We briefly motivate the scientific goals, and then give a detailed discussion of the APOLLO instrumentation.

  7. Preliminary Assessment of Apache Hopefulness: Relationships with Hopelessness and with Collective as well as Personal Self-Esteem

    Science.gov (United States)

    Hammond, Vanessa Lea; Watson, P. J.; O'Leary, Brian J.; Cothran, D. Lisa

    2009-01-01

    Hopelessness is central to prominent mental health problems within American Indian (AI) communities. Apaches living on a reservation in Arizona responded to diverse expressions of hope along with Hopelessness, Personal Self-Esteem, and Collective Self-Esteem scales. An Apache Hopefulness Scale expressed five themes of hope and correlated…

  8. Scoring Systems for Outcome Prediction in a Cardiac Surgical Intensive Care Unit: A Comparative Study.

    Science.gov (United States)

    Exarchopoulos, Themistocles; Charitidou, Efstratia; Dedeilias, Panagiotis; Charitos, Christos; Routsi, Christina

    2015-07-01

    Most scoring systems used to predict clinical outcome in critical care were not designed for application in cardiac surgery patients. To compare the predictive ability of the most widely used scoring systems (Acute Physiology and Chronic Health Evaluation [APACHE] II, Simplified Acute Physiology Score [SAPS] II, and Sequential Organ Failure Assessment [SOFA]) and of 2 specialized systems (European System for Cardiac Operative Risk Evaluation [EuroSCORE] II and the cardiac surgery score [CASUS]) for clinical outcome in patients after cardiac surgery. Consecutive patients admitted to a cardiac surgical intensive care unit (CSICU) were prospectively studied. Data on the preoperative condition, intraoperative parameters, and postoperative course were collected. EuroSCORE II, CASUS, and scores from 3 general severity-scoring systems (APACHE II, SAPS II, and SOFA) were calculated on the first postoperative day. Clinical outcome was defined as 30-day mortality and in-hospital morbidity. A total of 150 patients were included. Thirty-day mortality was 6%. CASUS was superior in outcome prediction, both in relation to discrimination (area under curve, 0.89) and calibration (Brier score = 0.043, χ(2) = 2.2, P = .89), followed by EuroSCORE II for 30-day mortality (area under curve, 0.87) and SOFA for morbidity (Spearman ρ= 0.37 and 0.35 for the CSICU length of stay and duration of mechanical ventilation, respectively; Wilcoxon W = 367.5, P = .03 for probability of readmission to CSICU). CASUS can be recommended as the most reliable and beneficial option for benchmarking and risk stratification in cardiac surgery patients. ©2015 American Association of Critical-Care Nurses.

  9. Characterization of vibration transfer paths in nose gearboxes of an AH-64 Apache

    Science.gov (United States)

    Islam, A. K. M. Anwarul; Dempsey, Paula J.; Feldman, Jason; Larsen, Chris

    2014-03-01

    Health monitoring of rotorcraft components, which is currently being performed by Health and Usage Monitoring Systems (HUMS) through analyzing vibration signatures of dynamic mechanical components, is very important for their safe and economic operation. Vibration diagnostic algorithms in HUMS analyze vibration signatures associated with faults and quantify them as condition indicators (CI) to predict component behavior. Vibration transfer paths (VTP) play important roles in CI response and are characterized by frequency response functions (FRF) derived from vibration signatures of dynamic mechanical components of a helicopter. With an objective to investigate the difference in VTP of a component in a helicopter and test stand, and to relate that to the CI response, VTP measurements were recorded from 0-50 kHz under similar conditions in the left and right nose gearboxes (NGBs) of an AH-64 Apache and an isolated left NGB in a test stand at NASA Glenn Research Center. The test fixture enabled the application of measured torques - common during an actual operation. Commercial and lab piezo shakers, and an impact hammer were used in both systems to collect the vibration response using two types of commercially available accelerometers under various test conditions. The FRFs of both systems were found to be consistent, and certain real-world installation and maintenance issues, such as sensor alignments, locations and installation torques, had minimal effect on the VTP. However, gear vibration transfer path dynamics appeared to be somewhat dependent on presence of oil, and the lightly-damped ring gear produced sharp and closer transfer path resonances.

  10. Prediction and observation of II-VI/CuInSe[sub 2] heterojunction band offsets

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Art J.; Niles, D.W.; Schwerdtfeger, C.R.; Wei, Su-Huai; Zunger, Alex (National Renewable Energy Lab., Golden, CO (United States)); Hoechst, H. (Synchrotron Radiation Center, Univ. of Wisconsin-Madison, Stoughton, WI (United States))

    1994-05-06

    First-principles band structure calculations show that II-VI/CuInSe[sub 2] heterojunctions have significant band offsets which challenge the traditional explanation of device operation. In the case of ZnSe, these large valence band offsets demonstrate the failure of the 'common anion rule'. This is traced to a stronger Cu,d-Se,p level repulsion in CuInSe[sub 2] than the Zn,d-Se,p repulsion in ZnSe. Formation of the ZnSe/CuInSe[sub 2] and CdS/CuInSe[sub 2] heterojunctions were studied by synchrotron radiation soft X-ray photoemission spectroscopy. The II-VI overlayers were sequentially grown in steps on both CuInSe[sub 2](112) single-crystals and polycrystalline thin-films. In situ photoemission measurements were acquired after each growth in order to observe changes in the valence band electronic structure as well as changes in the appropriate core lines. Results of these measurements reveal that the offsets are in good agreement with the first-principles predictions and that the traditional device model with [Delta]E[sub c]<0 must be abandoned

  11. Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method

    Directory of Open Access Journals (Sweden)

    Lund Ole

    2007-07-01

    Full Text Available Abstract Background Antigen presenting cells (APCs sample the extra cellular space and present peptides from here to T helper cells, which can be activated if the peptides are of foreign origin. The peptides are presented on the surface of the cells in complex with major histocompatibility class II (MHC II molecules. Identification of peptides that bind MHC II molecules is thus a key step in rational vaccine design and developing methods for accurate prediction of the peptide:MHC interactions play a central role in epitope discovery. The MHC class II binding groove is open at both ends making the correct alignment of a peptide in the binding groove a crucial part of identifying the core of an MHC class II binding motif. Here, we present a novel stabilization matrix alignment method, SMM-align, that allows for direct prediction of peptide:MHC binding affinities. The predictive performance of the method is validated on a large MHC class II benchmark data set covering 14 HLA-DR (human MHC and three mouse H2-IA alleles. Results The predictive performance of the SMM-align method was demonstrated to be superior to that of the Gibbs sampler, TEPITOPE, SVRMHC, and MHCpred methods. Cross validation between peptide data set obtained from different sources demonstrated that direct incorporation of peptide length potentially results in over-fitting of the binding prediction method. Focusing on amino terminal peptide flanking residues (PFR, we demonstrate a consistent gain in predictive performance by favoring binding registers with a minimum PFR length of two amino acids. Visualizing the binding motif as obtained by the SMM-align and TEPITOPE methods highlights a series of fundamental discrepancies between the two predicted motifs. For the DRB1*1302 allele for instance, the TEPITOPE method favors basic amino acids at most anchor positions, whereas the SMM-align method identifies a preference for hydrophobic or neutral amino acids at the anchors. Conclusion

  12. Lutzomyia (Helcocyrtomyia) Apache Young and Perkins (Diptera: Psychodidae) feeds on reptiles

    Science.gov (United States)

    Phlebotomine sand flies are vectors of bacteria, parasites, and viruses. In the western USA a sand fly, Lutzomyia apache Young and Perkins, was initially associated with epizootics of vesicular stomatitis virus (VSV), because sand flies were trapped at sites of an outbreak. Additional studies indica...

  13. Pathogens and bionomics of Lutzomyia apache (Diptera: Psychodidae) from Wyoming, USA

    Science.gov (United States)

    Phlebotomine sand flies are vectors of bacteria, parasites, and viruses. Lutzomyia apache, a North American sand fly, was incriminated as a vector of vesicular stomatitis viruses (VSV) due to overlapping ranges of the sand fly and recent outbreaks of VSV. We report on the discovery of two population...

  14. 基于Linwx的Apache Web网络系统安全技术

    Institute of Scientific and Technical Information of China (English)

    王伟

    2003-01-01

    世界上过半数的网站用Apache作为基于Linux的Web服务器,因此它的安全就成为人们最为关注的问题,本章针对Apache的安全隐患,进行安全配置,以提高Apache Web的安全.

  15. A Photographic Essay of the San Carlos Apache Indians, Volume 2-Part A.

    Science.gov (United States)

    Soto, Ed; And Others

    As part of a series of guides designed for instruction of American Indian children and youth, this resource guide constitutes a pictorial essay on the San Carlos Apache Reservation founded in the late 1800's and located in Arizona's Gila County. An historical narrative and discussion questions accompany each of the 12 photographs. Photographic…

  16. A Season on the Reservation: My Sojourn with the White Mountain Apache.

    Science.gov (United States)

    Abdul-Jabbar, Kareem; Singular, Stephen

    In this book, basketball legend Kareem Abdul-Jabbar tells of one basketball season when he coached a high school team on the White Mountain Apache Reservation (Arizona). Tired of life in Los Angeles, disillusioned with pro basketball, and devastated by the death of his mother, Abdul-Jabbar accepted an invitation to coach the team at Alchesay High…

  17. Survival of Apache Trout eggs and alevins under static and fluctuating temperature regimes

    Science.gov (United States)

    Recsetar, Matthew S.; Bonar, Scott A.

    2013-01-01

    Increased stream temperatures due to global climate change, livestock grazing, removal of riparian cover, reduction of stream flow, and urbanization will have important implications for fishes worldwide. Information exists that describes the effects of elevated water temperatures on fish eggs, but less information is available on the effects of fluctuating water temperatures on egg survival, especially those of threatened and endangered species. We tested the posthatch survival of eyed eggs and alevins of Apache Trout Oncorhynchus gilae apache, a threatened salmonid, in static temperatures of 15, 18, 21, 24, and 27°C, and also in treatments with diel fluctuations of ±3°C around those temperatures. The LT50 for posthatch survival of Apache Trout eyed eggs and alevins was 17.1°C for static temperatures treatments and 17.9°C for the midpoints of ±3°C fluctuating temperature treatments. There was no significant difference in survival between static temperatures and fluctuating temperatures that shared the same mean temperature, yet there was a slight difference in LT50s. Upper thermal tolerance of Apache Trout eyed eggs and alevins is much lower than that of fry to adult life stages (22–23°C). Information on thermal tolerance of early life stages (eyed egg and alevin) will be valuable to those restoring streams or investigating thermal tolerances of imperiled fishes.

  18. Forest resources of the Forest resources of the Apache-Sitgreaves National Forest

    Science.gov (United States)

    Paul Rogers

    2008-01-01

    The Interior West Forest Inventory and Analysis (IWFIA) program of the USDA Forest Service, Rocky Mountain Research Station, as part of its national Forest Inventory and Analysis (FIA) duties, conducted forest resource inventories of the Southwestern Region (Region 3) National Forests. This report presents highlights of the Apache-Sitgreaves National Forest...

  19. 77 FR 18997 - Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger...

    Science.gov (United States)

    2012-03-29

    ...] [FR Doc No: 2012-7527] DEPARTMENT OF AGRICULTURE Forest Service Rim Lakes Forest Restoration Project; Apache-Sitgreavese National Forest, Black Mesa Ranger District, Coconino County, AZ AGENCY: Forest.... Forest Service (FS) will prepare an environmental impact statement (EIS) on a proposed action to conduct...

  20. White Mountain Apache Language: Issues in Language Shift, Textbook Development, and Native Speaker-University Collaboration.

    Science.gov (United States)

    Adley-SantaMaria, Bernadette

    This paper is an overview of topics covered at two sessions of the Fourth Annual Stabilizing Indigenous Languages Symposium, from the perspective of a native speaker of an indigenous language and member of a university academic community. The first section describes a Master's thesis on White Mountain Apache (WMA) language shift. Interviews with…

  1. NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction

    Directory of Open Access Journals (Sweden)

    Lund Ole

    2009-09-01

    Full Text Available Abstract Background The major histocompatibility complex (MHC molecule plays a central role in controlling the adaptive immune response to infections. MHC class I molecules present peptides derived from intracellular proteins to cytotoxic T cells, whereas MHC class II molecules stimulate cellular and humoral immunity through presentation of extracellularly derived peptides to helper T cells. Identification of which peptides will bind a given MHC molecule is thus of great importance for the understanding of host-pathogen interactions, and large efforts have been placed in developing algorithms capable of predicting this binding event. Results Here, we present a novel artificial neural network-based method, NN-align that allows for simultaneous identification of the MHC class II binding core and binding affinity. NN-align is trained using a novel training algorithm that allows for correction of bias in the training data due to redundant binding core representation. Incorporation of information about the residues flanking the peptide-binding core is shown to significantly improve the prediction accuracy. The method is evaluated on a large-scale benchmark consisting of six independent data sets covering 14 human MHC class II alleles, and is demonstrated to outperform other state-of-the-art MHC class II prediction methods. Conclusion The NN-align method is competitive with the state-of-the-art MHC class II peptide binding prediction algorithms. The method is publicly available at http://www.cbs.dtu.dk/services/NetMHCII-2.0.

  2. Prediction of the survival and functional ability of severe stroke patients after ICU therapeutic intervention

    Directory of Open Access Journals (Sweden)

    Aoun-Bacha Zeina

    2008-06-01

    Full Text Available Abstract Background This study evaluated the benefits and impact of ICU therapeutic interventions on the survival and functional ability of severe cerebrovascular accident (CVA patients. Methods Sixty-two ICU patients suffering from severe ischemic/haemorrhagic stroke were evaluated for CVA severity using APACHE II and the Glasgow coma scale (GCS. Survival was determined using Kaplan-Meier survival tables and survival prediction factors were determined by Cox multivariate analysis. Functional ability was assessed using the stroke impact scale (SIS-16 and Karnofsky score. Risk factors, life support techniques and neurosurgical interventions were recorded. One year post-CVA dependency was investigated using multivariate analysis based on linear regression. Results The study cohort constituted 6% of all CVA (37.8% haemorrhagic/62.2% ischemic admissions. Patient mean(SD age was 65.8(12.3 years with a 1:1 male: female ratio. During the study period 16 patients had died within the ICU and seven in the year following hospital release. The mean(SD APACHE II score at hospital admission was 14.9(6.0 and ICU mean duration of stay was 11.2(15.4 days. Mechanical ventilation was required in 37.1% of cases. Risk ratios were; GCS at admission 0.8(0.14, (p = 0.024, APACHE II 1.11(0.11, (p = 0.05 and duration of mechanical ventilation 1.07(0.07, (p = 0.046. Linear coefficients were: type of CVA – haemorrhagic versus ischemic: -18.95(4.58 (p = 0.007, GCS at hospital admission: -6.83(1.08, (p = 0.001, and duration of hospital stay -0.38(0.14, (p = 0.40. Conclusion To ensure a better prognosis CVA patients require ICU therapeutic interventions. However, as we have shown, where tests can determine the worst affected patients with a poor vital and functional outcome should treatment be withheld?

  3. Installation and Configuration of Apache+ Php4+ MySQL under Solaris7%Apache+Php4+MySQL在Solaris7下的安装与配置

    Institute of Scientific and Technical Information of China (English)

    余海萍

    2003-01-01

    为了使Solaris 7支持动态网页的WEB服务,将Apache+Php4+MySQL安装到Solaris 7下.介绍Apache、Php4、MySQL等3个工具的解压、编译和安装,并详述Apache+Php4+MySQL配置和有效性验证的具体方法.安装后的Solaris 7+Apache+MySQL+Php网站能很好支持动态网页服务.

  4. The U.S. Government and the Apache Indians, 1871-1876: A Case Study in Counterinsurgency

    Science.gov (United States)

    1993-06-05

    first-hand accounts from the Apaches themselves. The best sources in this category are: I Fought with Geronimo by Jason Betzinez and the narratives...information, see E. Lisle Reedstrom, Apache Wars (New York: Sterling Publishing, 1990), p. 18. 16Terrell, Apache Chronicle, p. 81. ’I7bid., p. 84. ’$Lockwood...Chronicle, pp. 186-196. 24Ibid., pp. 202-203. 2 5 Thrapp, Conauest of ADacheria, p. 13. For a more detailed account of this incident, see Jason

  5. Inadvertent interchange of electrocardiogram limb lead connections: analysis of predicted consequences part II: double interconnection errors.

    Science.gov (United States)

    Rowlands, Derek J

    2012-01-01

    Limb lead connection errors are known to be very common in clinical practice. The consequences of all possible single limb lead interconnection errors were analyzed in an earlier publication (J Electrocardiology 2008;41:84-90). With a single limb lead interconnection error, 6 combinations of limb lead connections are possible. Two of these combinations give rise to records in which the limb lead morphology is uninterpretable. Such records show a "flat line" in lead II or III. Three of the errors give rise to records that are fully interpretable once the specific interconnection error has been identified (although one of the errors cannot reliably be recognized in the absence of a previous record for comparison). One of the errors produces no change in the electrocardiogram recording. In all cases, the precordial leads are interpretable, although there are very minor changes in the voltages. This communication predicts the changes in limb lead appearances consequent upon all possible double limb lead interchanges and illustrates these with records electively taken with such double interconnection errors. There are only 3 possible double limb lead interconnection errors. In 2 of the possible combinations, interpretation of the limb leads is impossible, and each of these errors gives rise to a flat line in lead I. In the third combination, the record is fully interpretable once the abnormality has been identified. In all 3 types, the precordial leads are interpretable, although there are very minor changes in the voltages.

  6. Dynamically Scaling Apache Storm for the Analysis of Streaming Data

    NARCIS (Netherlands)

    Veen, J.S. van der; Waaij, B.D. van der; Lazovik, E.; Wijbrandi, W.E.; Meijer, R.J.

    2015-01-01

    Stream processing platforms allow applications to analyse incoming data continuously. Several use cases exist that make use of these capabilities, ranging from monitoring of physical infrastructures to pre selecting video surveillance feeds for human inspection. It is difficult to predict how much

  7. Dynamically Scaling Apache Storm for the Analysis of Streaming Data

    NARCIS (Netherlands)

    Veen, J.S. van der; Waaij, B.D. van der; Lazovik, E.; Wijbrandi, W.E.; Meijer, R.J.

    2015-01-01

    Stream processing platforms allow applications to analyse incoming data continuously. Several use cases exist that make use of these capabilities, ranging from monitoring of physical infrastructures to pre selecting video surveillance feeds for human inspection. It is difficult to predict how much c

  8. User-tailored Inter-Widget Communication - Extending the Shared Data Interface for the Apache Wookie Engine

    NARCIS (Netherlands)

    Hoisl, Bernhard; Drachsler, Hendrik; Waglecher, Christoph

    2010-01-01

    Hoisl, B., Drachsler, H., & Waglecher, C. (2010). User-tailored Inter-Widget Communication. Extending the Shared Data Interface for the Apache Wookie Engine, International Conference on Interactive Computer Aided Learning 2010, Hasselt, Belgium.

  9. Apache并发连接数量控制%The Control of Simultaneous Connections for Apache Server

    Institute of Scientific and Technical Information of China (English)

    李绪; 陈诗明; 姜军

    2008-01-01

    文章针对Apache web服务器并发连接数控制问题,提出了三种解决方法:调整Apache自身参数MaxClients,使用第三方提供的Apache的模块mod_limitipconn,使用iptables的connlimit target,以控制Apache web服务器的并发连接数.

  10. Predicting critical temperatures of iron(II) spin crossover materials: density functional theory plus U approach.

    Science.gov (United States)

    Zhang, Yachao

    2014-12-07

    A first-principles study of critical temperatures (T(c)) of spin crossover (SCO) materials requires accurate description of the strongly correlated 3d electrons as well as much computational effort. This task is still a challenge for the widely used local density or generalized gradient approximations (LDA/GGA) and hybrid functionals. One remedy, termed density functional theory plus U (DFT+U) approach, introduces a Hubbard U term to deal with the localized electrons at marginal computational cost, while treats the delocalized electrons with LDA/GGA. Here, we employ the DFT+U approach to investigate the T(c) of a pair of iron(II) SCO molecular crystals (α and β phase), where identical constituent molecules are packed in different ways. We first calculate the adiabatic high spin-low spin energy splitting ΔE(HL) and molecular vibrational frequencies in both spin states, then obtain the temperature dependent enthalpy and entropy changes (ΔH and ΔS), and finally extract T(c) by exploiting the ΔH/T - T and ΔS - T relationships. The results are in agreement with experiment. Analysis of geometries and electronic structures shows that the local ligand field in the α phase is slightly weakened by the H-bondings involving the ligand atoms and the specific crystal packing style. We find that this effect is largely responsible for the difference in T(c) of the two phases. This study shows the applicability of the DFT+U approach for predicting T(c) of SCO materials, and provides a clear insight into the subtle influence of the crystal packing effects on SCO behavior.

  11. Food patterns associated with blood lipids are predictive of coronary heart disease: the Whitehall II study.

    Science.gov (United States)

    McNaughton, Sarah A; Mishra, Gita D; Brunner, Eric J

    2009-08-01

    Analysis of the epidemiological effects of overall dietary patterns offers an alternative approach to the investigation of the role of diet in CHD. We analysed the role of blood lipid-related dietary patterns using a two-step method to confirm the prospective association of dietary pattern with incident CHD. Analysis is based on 7314 participants of the Whitehall II study. Dietary intake was measured using a 127-item FFQ. Reduced rank regression (RRR) was used to derive dietary pattern scores using baseline serum total and HDL-cholesterol, and TAG levels as dependent variables. Cox proportional hazard regression was used to confirm the association between dietary patterns and incident CHD (n 243) over 15 years of follow-up. Increased CHD risk (hazard ratio (HR) for top quartile: 2.01 (95% CI 1.41, 2.85) adjusted for age, sex, ethnicity and energy misreporting) was observed with a diet characterised by high consumption of white bread, fried potatoes, sugar in tea and coffee, burgers and sausages, soft drinks, and low consumption of French dressing and vegetables. The diet-CHD relationship was attenuated after adjustment for employment grade and health behaviours (HR for top quartile: 1.81; 95% CI 1.26, 2.62), and further adjustment for blood pressure and BMI (HR for top quartile: 1.57; 95% CI 1.08, 2.27). Dietary patterns are associated with serum lipids and predict CHD risk after adjustment for confounders. RRR identifies dietary patterns using prior knowledge and focuses on the pathways through which diet may influence disease. The present study adds to the evidence that diet is an important risk factor for CHD.

  12. Large-scale virtual screening on public cloud resources with Apache Spark.

    Science.gov (United States)

    Capuccini, Marco; Ahmed, Laeeq; Schaal, Wesley; Laure, Erwin; Spjuth, Ola

    2017-01-01

    Structure-based virtual screening is an in-silico method to screen a target receptor against a virtual molecular library. Applying docking-based screening to large molecular libraries can be computationally expensive, however it constitutes a trivially parallelizable task. Most of the available parallel implementations are based on message passing interface, relying on low failure rate hardware and fast network connection. Google's MapReduce revolutionized large-scale analysis, enabling the processing of massive datasets on commodity hardware and cloud resources, providing transparent scalability and fault tolerance at the software level. Open source implementations of MapReduce include Apache Hadoop and the more recent Apache Spark. We developed a method to run existing docking-based screening software on distributed cloud resources, utilizing the MapReduce approach. We benchmarked our method, which is implemented in Apache Spark, docking a publicly available target receptor against [Formula: see text]2.2 M compounds. The performance experiments show a good parallel efficiency (87%) when running in a public cloud environment. Our method enables parallel Structure-based virtual screening on public cloud resources or commodity computer clusters. The degree of scalability that we achieve allows for trying out our method on relatively small libraries first and then to scale to larger libraries. Our implementation is named Spark-VS and it is freely available as open source from GitHub (https://github.com/mcapuccini/spark-vs).Graphical abstract.

  13. Factors predicting survival for HIV-infected patients with respiratory failure.

    Science.gov (United States)

    van Leeuwen, H J; Boereboom, F T; Pols, M A; Hoepelman, A I; Savelkoul, J T

    2000-09-01

    Despite improved treatment modalities, the mortality of HIV infected patients admitted to the intensive care unit with respiratory failure remains high. To help ICU physicians in advising HIV infected patients whether to undergo mechanical ventilation, we retrospectively investigated prognostic factors predicting hospital outcome for HIV-infected patients, admitted to a medical intensive care unit with respiratory failure before the era of highly-active anti-retroviral therapy. A retrospective chart review was carried out of all HIV-infected patients with respiratory failure admitted to the medical ICU of a Dutch University Hospital between 1991 and 1997. In the six year period, 29 HIV-infected patients were admitted to the ICU for respiratory failure. Mechanical ventilation, CD4 cell count, APACHE II score, APACHE III score, ARDS and length of ICU stay all differed significantly between survivors and non-survivors. However, a multivariate analysis only showed the need for mechanical ventilation as an independent risk factor for mortality. The only combination of factors able to accurately predict mortality for the individual patient was the development of ARDS and the requirement of mechanical ventilation. The combination of mechanical ventilation and ARDS accurately predicts hospital outcome in HIV-infected patients presenting with respiratory failure before the HAART era.

  14. Prediction

    CERN Document Server

    Sornette, Didier

    2010-01-01

    This chapter first presents a rather personal view of some different aspects of predictability, going in crescendo from simple linear systems to high-dimensional nonlinear systems with stochastic forcing, which exhibit emergent properties such as phase transitions and regime shifts. Then, a detailed correspondence between the phenomenology of earthquakes, financial crashes and epileptic seizures is offered. The presented statistical evidence provides the substance of a general phase diagram for understanding the many facets of the spatio-temporal organization of these systems. A key insight is to organize the evidence and mechanisms in terms of two summarizing measures: (i) amplitude of disorder or heterogeneity in the system and (ii) level of coupling or interaction strength among the system's components. On the basis of the recently identified remarkable correspondence between earthquakes and seizures, we present detailed information on a class of stochastic point processes that has been found to be particu...

  15. Prediction of potential mushroom yield by visible and near-infrared spectroscopy using fresh phase II compost.

    Science.gov (United States)

    Sharma, H S S; Kilpatrick, M; Lyons, G

    2005-08-01

    Potential mushroom (Agaricus bisporus) yield of phase II compost is determined by interactions of key quality parameters including dry matter, nitrogen dry matter, ammonia, pH, conductivity, thermophilic microorganisms, C : N ratio, fiber fractions, ash, and certain minerals. This study was aimed at generating robust visible and near-infrared (Vis-NIR) calibrations for predicting potential yield, using spectra from fresh phase II compost. Four compost comparative trials were carried out during the winter and summer months of 2001-2003, under controlled experimental conditions employing six commercially prepared composts, with eight replicate (8 bag) plots per treatment (48 x 8 = 384). The substrates were prepared by windrow or bunker phase I, followed by phase II production. The fresh samples were scanned for Vis-NIR (400-2498 nm) spectra, averaged, transformed, and regressed against the recorded yield by employing a modified partial least squares algorithm. The best calibration model generated from the database explained 84% of yield variation within the data set with a standard error of calibration of 13.75 kg/tonne of fresh compost. The model was successfully tested for robustness with yield results obtained from a validation trial, carried out under similar experimental conditions in early 2004, and the standard error of prediction was 18.21 kg/tonne, which was slightly higher than the mean experimental error (17.94 kg/tonne) of the trial. The accuracy of the model is acceptable for estimating potential yield by classifying phase II substrate as poor (180-220 kg), medium (220-260 kg), and high (260-300 kg) yielding compost. The yield prediction model is being transferred to a new instrument based at Loughgall for routine evaluation of commercial phase II samples.

  16. Comparing the Predictions of two Mixed Neutralino Dark Matter Models with the Recent CDMS II Candidate Events

    CERN Document Server

    Roy, D P

    2010-01-01

    We consider two optimally mixed neutralino dark matter models, based on nonuniversal gaugino masses, which were recently proposed by us to achieve WMAP compatible relic density over a large part of the MSSM parameter space. We compare the resulting predictions for the spin-independent DM scattering cross-section with the recent CDMS II data, assuming the possibility of the two reported candidate events being signal events. For one model the predicted cross-section agrees with the putative signal over a small part of the parameter space, while for the other the agreement holds over the entire WMAP compatible parameter space of the model.

  17. Artificial neural network based calibrations for the prediction of galactic [N II] λ6584 and Hα line luminosities

    Science.gov (United States)

    Teimoorinia, Hossein; Ellison, Sara L.

    2014-04-01

    The artificial neural network (ANN) is a well-established mathematical technique for data prediction, based on the identification of correlations and pattern recognition in input training sets. We present the application of ANNs to predict the emission line luminosities of Hα and [N II] λ6584 in galaxies. These important spectral diagnostics are used for metallicities, active galactic nuclei (AGN) classification and star formation rates, yet are shifted into the infrared for galaxies above z ˜ 0.5, or may not be covered in spectra with limited wavelength coverage. The ANN is trained with a large sample of emission line galaxies selected from the Sloan Digital Sky Survey (SDSS) using various combinations of emission lines and stellar mass. The ANN is tested for galaxies dominated by both star formation and AGN; in both cases the Hα and [N II] λ6584 line luminosities can be predicted with a scatter σ Galaxy Mass and Assembly Survey). We demonstrate the application of our line luminosities to the determination of gas-phase metallicities and AGN classification. The ANN technique yields a significant improvement in the measurement of metallicities that require [N II] and Hα when compared with the function-based conversions of Kewley & Ellison. The AGN classification is successful for 86 per cent of SDSS galaxies.

  18. Deciphering protein-protein interactions. Part II. Computational methods to predict protein and domain interaction partners

    National Research Council Canada - National Science Library

    Shoemaker, Benjamin A; Panchenko, Anna R

    2007-01-01

    .... In this review we describe different approaches to predict protein interaction partners as well as highlight recent achievements in the prediction of specific domains mediating protein-protein interactions...

  19. Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

    NARCIS (Netherlands)

    Pena, Michelle J.; Heinzel, Andreas; Rossing, Peter; Parving, Hans-Henrik; Dallmann, Guido; Rossing, Kasper; Andersen, Steen; Mayer, Bernd; Heerspink, Hiddo J. L.

    2016-01-01

    Background: Individual patients show a large variability in albuminuria response to angiotensin receptor blockers (ARB). Identifying novel biomarkers that predict ARB response may help tailor therapy. We aimed to discover and validate a serum metabolite classifier that predicts albuminuria response

  20. Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma.

    Science.gov (United States)

    Mandel, Jacob J; Yust-Katz, Shlomit; Patel, Akash J; Cachia, David; Liu, Diane; Park, Minjeong; Yuan, Ying; A Kent, Thomas; de Groot, John F

    2017-07-31

    Glioblastoma is the most common primary malignant brain tumor in adults, but effective therapies are lacking. With the scarcity of positive phase III trials, which are increasing in cost, we examined the ability of positive phase II trials to predict statistically significant improvement in clinical outcomes of phase III trials. A PubMed search was conducted to identify phase III clinical trials performed in the past 25 years for patients with newly diagnosed or recurrent glioblastoma. Trials were excluded if they did not examine an investigational chemotherapy or agent, if they were stopped early owing to toxicity, if they lacked prior phase II studies, or if a prior phase II study was negative. Seven phase III clinical trials in newly diagnosed glioblastoma and 4 phase III clinical trials in recurrent glioblastoma met the inclusion criteria. Only 1 (9%) phase III study documented an improvement in overall survival and changed the standard of care. The high failure rate of phase III trials demonstrates the urgent need to increase the reliability of phase II trials of treatments for glioblastoma. Strategies such as the use of adaptive trial designs, Bayesian statistics, biomarkers, volumetric imaging, and mathematical modeling warrant testing. Additionally, it is critical to increase our expectations of phase II trials so that positive findings increase the probability that a phase III trial will be successful.

  1. 脓毒症血清降钙素原与APACHEⅡ评分的相关性%CORRELATION BETWEEN SERUM LEVEL OF PROCALCITONIN AND APACHE Ⅱ SCORE IN PATIENTS WITH SEPSIS

    Institute of Scientific and Technical Information of China (English)

    袁东; 于海初

    2012-01-01

    目的 观察脓毒症病人血清降钙素原(PCT)水平与APACHEⅡ评分之间的相关性.方法 检测脓毒症病人74例(其中脓毒症28例,严重脓毒症25例,脓毒症休克21例)、非脓毒血症病人24例血清PCT及C反应蛋白(CRP)水平,行APACHEⅡ评分,分析PCT、CRP水平与APACHEⅡ评分相关性.结果 脓毒症、严重脓毒症和脓毒症休克病人的血清PCT、CRP水平和APACHEⅡ评分均高于非脓毒症病人,差异有显著意义(F=7.07~441.87,q=3.18~48.14,P<0.05).脓毒症病人PCT水平、APACHEⅡ评分随病情严重程度升高而升高,差异有显著性(q=10.06~48.14,P<0.05);PCT水平与APACHEⅡ评分呈正相关(r=0.68,P<0.05).结论 脓毒症病人PCT水平与APACHEⅡ评分有相关性,PCT在脓毒症诊断中的价值优于CRP.%Objective To study the correlation of serum level of procalcitonin (PCT) with score of APACHE Ⅱ in patients with sepsis. Methods Serum levels of PCT and C-reactive protein (CRP) in 74 patients with sepsis, which included sepsis (28 cases), severe sepsis (25) and septic shock (21) , and 24 patients with non-sepsis were detected. APACHE II score was done. The correlation of the score with PCT and C-reactive protein (CRP) was analyzed. Results Serum levels of PCT and CRP, and APACHE Ⅱ scores in patients with sepsis, severe sepsis and septic shock were significantly higher than that in the non-septic patients (F=7. 07-441. 87,q= 3.18 - 48.14,P<0. 05). PCT levels and APACHE D scores elevated along with the severity of the disease (q= 10. 06-48.14,P<0. 05). The level of PCT was positively correlated with APACHEⅡ (r=0. 68,P<0. 05). Conclusion There is a positive correlation of PCT with APACHE Ⅱ score in patients with sepsis. The serum level of PCT is superior to CRP in the diagnosis of sepsis

  2. Numerical Predictions of Wind Turbine Power and Aerodynamic Loads for the NREL Phase II and IV Combined Experiment Rotor

    Science.gov (United States)

    Duque, Earl P. N.; Johnson, Wayne; vanDam, C. P.; Chao, David D.; Cortes, Regina; Yee, Karen

    1999-01-01

    Accurate, reliable and robust numerical predictions of wind turbine rotor power remain a challenge to the wind energy industry. The literature reports various methods that compare predictions to experiments. The methods vary from Blade Element Momentum Theory (BEM), Vortex Lattice (VL), to variants of Reynolds-averaged Navier-Stokes (RaNS). The BEM and VL methods consistently show discrepancies in predicting rotor power at higher wind speeds mainly due to inadequacies with inboard stall and stall delay models. The RaNS methodologies show promise in predicting blade stall. However, inaccurate rotor vortex wake convection, boundary layer turbulence modeling and grid resolution has limited their accuracy. In addition, the inherently unsteady stalled flow conditions become computationally expensive for even the best endowed research labs. Although numerical power predictions have been compared to experiment. The availability of good wind turbine data sufficient for code validation experimental data that has been extracted from the IEA Annex XIV download site for the NREL Combined Experiment phase II and phase IV rotor. In addition, the comparisons will show data that has been further reduced into steady wind and zero yaw conditions suitable for comparisons to "steady wind" rotor power predictions. In summary, the paper will present and discuss the capabilities and limitations of the three numerical methods and make available a database of experimental data suitable to help other numerical methods practitioners validate their own work.

  3. Predicting Pattern Tooling and Casting Dimensions for Investment Casting, Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Nick Cannell (EMTEC); Adrian S. Sabau (ORNL)

    2005-09-30

    The investment casting process allows the production of complex-shape parts and close dimensional tolerances. One of the most important phases in the investment casting process is the design of the pattern die. Pattern dies are used to create wax patterns by injecting wax into dies. The first part of the project involved preparation of reports on the state of the art at that time for all the areas under consideration (die-wax, wax-shell, and shell-alloy). The primary R&D focus during Phase I was on the wax material since the least was known about it. The main R&D accomplishments during this phase were determination of procedures for obtaining the thermal conductivity and viscoelastic properties of an unfilled wax and validating those procedures. Phase II focused on die-wax and shell-alloy systems. A wax material model was developed based on results obtained during the previous R&D phase, and a die-wax model was successfully incorporated into and used in commercial computer programs. Current computer simulation programs have complementary features. A viscoelastic module was available in ABAQUS but unavailable in ProCAST, while the mold-filling module was available in ProCAST but unavailable in ABAQUS. Thus, the numerical simulation results were only in good qualitative agreement with experimental results, the predicted shrinkage factors being approximately 2.5 times larger than those measured. Significant progress was made, and results showed that the testing and modeling of wax material had great potential for industrial applications. Additional R&D focus was placed on one shell-alloy system. The fused-silica shell mold and A356 aluminum alloy were considered. The experimental part of the program was conducted at ORNL and commercial foundries, where wax patterns were injected, molds were invested, and alloys were poured. It was very important to obtain accurate temperature data from actual castings, and significant effort was made to obtain temperature profiles in

  4. Respiratory syncytial virus infection in Navajo and White Mountain Apache children.

    Science.gov (United States)

    Bockova, Jana; O'Brien, Katherine L; Oski, Jane; Croll, Janne'; Reid, Raymond; Weatherholtz, Robert C; Santosham, Mathuram; Karron, Ruth A

    2002-08-01

    The hospitalization rate for bronchiolitis of any cause among US children younger than 1 year is estimated at 31.2 per 1000. No data exist on respiratory syncytial virus (RSV)-specific hospitalization rates among high-risk Native Americans other than Alaska Natives, for whom the incidence of RSV hospitalization was estimated at 150 per 1000 among infants younger than 1 year. We aimed to estimate RSV hospitalization rates among Navajo and White Mountain Apache children younger than 2 years. We conducted prospective population-level hospital-based surveillance to determine RSV hospitalization rates among Navajo and White Mountain Apache children younger than 2 years. From 1997 to 2000, all children who were admitted for acute lower respiratory tract infection between October 1 and March 31 had a nasopharyngeal aspirate obtained and tested for RSV by commercial enzyme immunoassay kits. We reviewed charts of children who tested positive for RSV antigen to determine disease severity. During 3 RSV seasons (1997-2000), 51.3% of 1837 admissions for acute lower respiratory tract infection among children younger than 2 years were attributed to RSV infection. The overall seasonal RSV hospitalization rate among children younger than 2 years was 63.6 per 1000 and 91.3 per 1000 among children younger than 1 year. In a univariate analysis, predictors of severity included age <6 months (relative risk: 6.8; 95% confidence interval: 3.1-17.0). Navajo and White Mountain Apache children are at high risk for RSV disease requiring hospitalization. A lower threshold for hospitalization or underlying chronic conditions that predispose to severe RSV disease do not seem to explain high RSV hospitalization rates in this population.

  5. Prediction Value of CRIB-II in Outcome of Preterm and Low Birth Weight Infants: a Prospective Cohort Study

    Directory of Open Access Journals (Sweden)

    Mohammad Heidarzadeh

    2016-04-01

    Full Text Available Background: One of the most common methods of identifying mortality risk is the Clinical Risk Index for Babies scoring system (CRIB- II. The aim of this study was assessing the value of CRIB- II in predicting mortality risk in preterm and low birth weight infants in East Azerbaijan- Iran. Materials and Methods: This prospective cohort study was carried out in 2013-2014 during 6 months in NICUs of Alzahra, Taleqani and Children hospitals of Tabriz-Iran. All infants ≤ 32 weeks’ gestational age or ≤ 1500gr birth weight were included in the study using consecutive method. After calculating CRIB- II score, the infants were followed up at 3 months of age and their outcome was determined. The data was analyzed using SPSS-13, t- test, receiver operating characteristics (ROC and area under curve (AUC and relative risk (RR. Results: Of total 215 infants, 64 infants (29.7% died in the hospital and one infant (0.4% died after discharging from the hospital. 150 (68.8% infants, were alive at 3 months age follow up. The mean of CRIB- II score in the group of dead infants was higher and statistically significant compared to the group of alive infants (P

  6. Predicting ESR Peaks in Copper (II Chelates Having Quadrupolar Coordinating Sites by NMR, ESR and NQR Techniques: A DFT Study

    Directory of Open Access Journals (Sweden)

    Harminder Singh

    2015-06-01

    Full Text Available Computational chemistry was helpful in predicting the number of ESR peaks in Cu (II complexes having a large number of spatially different NMR and ESR active nuclei. The presence of the large Jahn-Teller effect and the high value of spin-orbit coupling constant of the metal ion made the experimental determination of the exact number of ESR peaks quite difficult in such complexes. Fourteen distorted poly-dentate chelating Cu(II complexes included in this study were of two types such as [Cu(gly2] , [Cu(edta]4-,[Cu(tpyX2] (X= Cl, Br, I, NCS and [Cu(en2]2+, [Cu(teta]2+, Cu(tepa]2+ ,[Cu(peha]2+, [Cu(detaX2] (X= Cl, Br, I, NCS.The latter eight complexes belonged to an important class of ligands called polyethylene polyamines. Density functional theory implemented in ADF: 2010.02 was applied. Three parameters of both the ESR (A ten and NQR (NQCC, for the Cu(II and the coordinating atoms of the ligands were obtained from “ESR/EPR program” and two NMR parameters namely the shielding constants (σ and chemical shifts (δ were obtained from “NMR/EPR program” after optimization of the complexes. The species having the same values of these 5 parameters were expected to be spatially equivalent to undergo the same hyperfine interaction with Cu (II.

  7. CT-guided percutaneous drainage of intra-abdominal abscesses: APACHE III score stratification of 1-year results

    Energy Technology Data Exchange (ETDEWEB)

    Betsch, Angelika; Belka, Claus [Department of Radiation Oncology, Eberhard Karls University, Hoppe-Seyler-Strasse 3, 72076 Tuebingen (Germany); Wiskirchen, Jakub; Truebenbach, Jochen; Claussen, Claus D.; Duda, Stephan H. [Department of Diagnostic Radiology, Eberhard Karls University, Hoppe-Seyler-Strasse 3, 72076 Tuebingen (Germany); Manncke, Klaus H. [Department of General Surgery, Eberhard Karls University, Hoppe-Seyler-Strasse 3, 72076 Tuebingen (Germany)

    2002-12-01

    Our objective was to evaluate the clinical success rates of percutaneously drained intra-abdominal abscesses using a risk stratification score for severely ill patients (APACHE III; Acute Physiology, Age, Chronic Health Evaluation). In 75 patients CT-guided percutaneous abscess drainage was performed to treat intra-abdominal abscesses. The clinical success rate based on a 1-year follow-up was correlated with abscess etiology, size, and structure, as well as with the initial APACHE III score. Clinical success, i.e., the complete removal of the abscess without surgical treatment, was observed in 62 of 75 patients (83%). Abscess size (<200 cm{sup 3}) and abscesses with a simple structure correlated with higher clinical success rates. Patients presenting with APACHE III scores below 30 were treated by percutaneous abscess drainages (PAD) alone significantly more often than patients presenting with higher APACHE scores. The percutaneous drainage of intra-abdominal abscesses shows good long-term results as long as abscesses are singular, small (<200 cm{sup 3}), and located in well accessible regions in combination with low APACHE scores (<30). (orig.)

  8. Advanced Phase Array Chemical Energy (APACHE) Laser Program; Final Report, Volume 2

    Science.gov (United States)

    2007-11-02

    APOPM Code Development 3.6-6 3.6.4 Phase Conjugate Amplifier Parameter Studies 3.6-9 4. ASAM MODEL 4-1 4.1 Background and Objectives 4-1. 4.2...individual modules in APOPM, as well as certain combinations of modules. Section 4 describes the APACHE Systems Analysis Model ( ASAM ), developed as a...comprehensive, yet convenient (runs on a PC), modeling tool to support both the SBL design effort, as well as systems effectiveness studies. The ASAM

  9. Apache Trail uranium prospect, White Signal district, Grant County, New Mexico

    Science.gov (United States)

    Bauer, Herman L.

    1951-01-01

    The Apache Trail uranium prospect in the White Signal district, Grant County. N. Mex., was mapped by the Geological Survey in May 1950. Pre-Cambrian granite is cut by a diabase dike and a parallel quartz-hematite vein, both of which strike easterly and dip 60 to 65 degrees north. Small quantities of copper carbonates and bismuth-gold ore have been mined. The quartz-hematite vein is moderately radioactive and, although no uranium minerals were seen, two samples contained about 0.01 percent uranium. The diabase dike locally contains torbernite. Two samples of diabase contained about 0.04 percent uranium.

  10. Apache Server-Status引发的旁注入侵

    Institute of Scientific and Technical Information of China (English)

    古典娃娃

    2010-01-01

    熟悉Apache的朋友都知道它的日志又多又杂.如果靠分析日志或者查看服务器进程来监视APache运行状态的话,比较繁冗。于是在Apache1.3.2及以后的版本中就自带了一个查看Apache状态的功能模块server-status。

  11. Setting up LAMP getting Linux, Apache, MySQL, and PHP working together

    CERN Document Server

    Rosebrock, Eric

    2006-01-01

    You could think of Setting Up LAMP as four books in one, but it''s actually something much more valuable: a single volume that presents the open-source technologies known collectively as LAMP-Linux, Apache, MySQL, and PHP-as tightly dovetailed components of today''s most affordable and effective platform for building dynamic web-based applications. Each technology has uses outside of this context, of course, but within it they form something greater than the sum of their parts. This book shows you how to take full advantage of this power, walking you through all the steps required to lay your

  12. Theoretical prediction of interference loading on aircraft stores: Part II - Supersonic speeds

    Science.gov (United States)

    Fox, C. H., Jr.; Fernandes, F.

    1973-01-01

    Linear theory is used, without two dimensional or slender body assumptions, to predict flow field produced by aircraft wing, nose, inlet, and pylons. Aircraft shock wave locations are predicted, and their effect on flow field is included through transformation of aircraft geometry. Program was written in FORTRAN IV for CDC 6400 computer.

  13. Predicting ICU survival: A meta-level approach

    Directory of Open Access Journals (Sweden)

    Stamoulis Konstantinos

    2008-07-01

    Full Text Available Abstract Background The performance of separate Intensive Care Unit (ICU status scoring systems vis-à-vis prediction of outcome is not satisfactory. Computer-based predictive modeling techniques may yield good results but their performance has seldom been extensively compared to that of other mature or emerging predictive models. The objective of the present study was twofold: to propose a prototype meta-level predicting approach concerning Intensive Care Unit (ICU survival and to evaluate the effectiveness of typical mining models in this context. Methods Data on 158 men and 46 women, were used retrospectively (75% of the patients survived. We used Glasgow Coma Scale (GCS, Acute Physiology And Chronic Health Evaluation II (APACHE II, Sequential Organ Failure Assessment (SOFA and Injury Severity Score (ISS values to structure a decision tree (DTM, a neural network (NNM and a logistic regression (LRM model and we evaluated the assessment indicators implementing Receiver Operating Characteristics (ROC plot analysis. Results Our findings indicate that regarding the assessment of indicators' capacity there are specific discrete limits that should be taken into account. The Az score ± SE was 0.8773± 0.0376 for the DTM, 0.8061± 0.0427 for the NNM and 0.8204± 0.0376 for the LRM, suggesting that the proposed DTM achieved a near optimal Az score. Conclusion The predicting processes of ICU survival may go "one step forward", by using classic composite assessment indicators as variables.

  14. Low Expression of TBX4 Predicts Poor Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Meijuan Zong

    2011-08-01

    Full Text Available This study was designed to investigate the expression of the T-box transcription factor 4 (TBX4, a tumor biomarker that was previously identified by proteomics, in pancreatic ductal adenocarcinoma (PDAC and evaluate its clinical utility as a potential prognostic biomarkers for PDAC. The expression of TBX4 was detected in 77 stage II PDAC tumors by immunohistochemistry, and the results were analyzed with regard to clinicopathological characteristics and overall survival. Moreover, Tbx4 promoter methylation status in primary PDAC tumors and normal adjacent pancreas tissues was measured by bisulfite sequencing. Among 77 stage II PDAC tumors, 48 cases (62.3% expressed TBX4 at a high level. No significant correlation between TBX4 expression and other clinicopathological parameters, except tumor grade and liver metastasis recurrence, was found. The survival of patients with TBX4-high expression was significantly longer than those with TBX4-low expression (P = 0.010. In multivariate analysis, low TBX4 expression was an independent prognostic factor for overall survival in patients with stage II PDAC. TBX4 promoter methylation status was frequently observed in both PDAC and normal adjacent pancreas. We conclude that a low level of TBX4 expression suggests a worse prognosis for patients with stage II PDAC. Down-regulation of the TBX4 gene in pancreas is less likely to be regulated by DNA methylation.

  15. Predicting rice hybrid performance using univariate and multivariate GBLUP models based on North Carolina mating design II.

    Science.gov (United States)

    Wang, X; Li, L; Yang, Z; Zheng, X; Yu, S; Xu, C; Hu, Z

    2017-03-01

    Genomic selection (GS) is more efficient than traditional phenotype-based methods in hybrid breeding. The present study investigated the predictive ability of genomic best linear unbiased prediction models for rice hybrids based on the North Carolina mating design II, in which a total of 115 inbred rice lines were crossed with 5 male sterile lines. Using 8 traits of the 575 (115 × 5) hybrids from two environments, both univariate (UV) and multivariate (MV) prediction analyses, including additive and dominance effects, were performed. Using UV models, the prediction results of cross-validation indicated that including dominance effects could improve the predictive ability for some traits in rice hybrids. Additionally, we could take advantage of GS even for a low-heritability trait, such as grain yield per plant (GY), because a modest increase in the number of top selection could generate a higher, more stable mean phenotypic value for rice hybrids. Thus this strategy was used to select superior potential crosses between the 115 inbred lines and those between the 5 male sterile lines and other genotyped varieties. In our MV research, an MV model (MV-ADV) was developed utilizing a MV relationship matrix constructed with auxiliary variates. Based on joint analysis with multi-trait (MT) or with multi-environment, the prediction results confirmed the superiority of MV-ADV over an UV model, particularly in the MT scenario for a low-heritability target trait (such as GY), with highly correlated auxiliary traits. For a high-heritability trait (such as thousand-grain weight), MT prediction is unnecessary, and UV prediction is sufficient.

  16. Two-step spin-switchable tetranuclear Fe(II) molecular solid: Ab initio theory and predictions

    Science.gov (United States)

    Maldonado, Pablo; Kanungo, Sudipta; Saha-Dasgupta, Tanusri; Oppeneer, Peter M.

    2013-07-01

    Using density functional theory supplemented with on-site Coulomb U interaction in combination with ab initio molecular dynamics simulations, we investigate the spin-crossover (SCO) properties of a Fe(II) based cyanide-bridged square molecular system, [FeII4(μ-CN)4(bpy)4(tpa)2](PF6)4 (where bpy = 2,2'-bipyridine and tpa = tris(2-pyridylmethyl)amine], exhibiting a two-step SCO transition. The ab initio calculated SCO temperatures are found to show remarkably good agreement with experimentally measured spin conversion temperatures [M. Nihei , Angew. Chem., Int. Ed.1433-785110.1002/anie.200502216 44, 6484 (2005)]. Our theoretical study predicts further chemo switching of the spin state by introduction of guest molecules such as CO2, CS2, and H2O into the porous topology of the system, which would add another dimensionality to this interesting material.

  17. Predictive Performance of the Simplified Acute Physiology Score (SAPS) II and the Initial Sequential Organ Failure Assessment (SOFA) Score in Acutely Ill Intensive Care Patients

    DEFF Research Database (Denmark)

    Granholm, Anders; Møller, Morten Hylander; Kragh, Mette

    2016-01-01

    PURPOSE: Severity scores including the Simplified Acute Physiology Score (SAPS) II and the Sequential Organ Failure Assessment (SOFA) score are used in intensive care units (ICUs) to assess disease severity, predict mortality and in research. We aimed to assess the predictive performance of SAPS II...... compared the discrimination of SAPS II and initial SOFA scores, compared the discrimination of SAPS II in our cohort with the original cohort, assessed the calibration of SAPS II customised to our cohort, and compared the discrimination for 90-day mortality vs. in-hospital mortality for both scores....... Discrimination was evaluated using areas under the receiver operating characteristics curves (AUROC). Calibration was evaluated using Hosmer-Lemeshow's goodness-of-fit Ĉ-statistic. RESULTS: AUROC for in-hospital mortality was 0.80 (95% confidence interval (CI) 0.77-0.83) for SAPS II and 0.73 (95% CI 0...

  18. Assessing the Incremental Value of KABC-II Luria Model Scores in Predicting Achievement: What Do They Tell Us beyond the MPI?

    Science.gov (United States)

    McGill, Ryan J.; Spurgin, Angelia R.

    2016-01-01

    The current study examined the incremental validity of the Luria interpretive scheme for the Kaufman Assessment Battery for Children-Second Edition (KABC-II) for predicting scores on the Kaufman Test of Educational Achievement-Second Edition (KTEA-II). All participants were children and adolescents (N = 2,025) drawn from the nationally…

  19. Assessing the Incremental Value of KABC-II Luria Model Scores in Predicting Achievement: What Do They Tell Us beyond the MPI?

    Science.gov (United States)

    McGill, Ryan J.; Spurgin, Angelia R.

    2016-01-01

    The current study examined the incremental validity of the Luria interpretive scheme for the Kaufman Assessment Battery for Children-Second Edition (KABC-II) for predicting scores on the Kaufman Test of Educational Achievement-Second Edition (KTEA-II). All participants were children and adolescents (N = 2,025) drawn from the nationally…

  20. Prediction of equilibrium parameters of adsorption of lead (II) ions onto diatomite

    Science.gov (United States)

    Salman, Taylan; Ardalı, Yüksel; Gamze Turan, N.

    2013-04-01

    Heavy metals from industrial wastewaters are one of the most important environmental issues to be solved today. Due to their toxicity and nonbiodegradable nature, heavy metals cause environmental and public health problems. Various techniques have been developed to remove heavy metals from aqueous solutions. These include chemical precipitation, reverse osmosis, ion Exchange and adsorption. Among them, adsorption is considered to be a particularly competitive and effective process for the removal of heavy metals from aqueous solutions. There is growing interest in using low cost, commercially available materials for the adsorption of heavy metals. Diatomite is a siliceous sedimentary rock having an amorphous form of silica (SiO2. nH2O) containing a small amount of microcrystalline material. It has unique combination of physical and chemical properties such as high porosity, high permeability, small particle size, large surface area, and low thermal conductivity. In addition, it is available in Turkey and in various locations around the world. Therefore, diatomite has been successfully used as adsorbent for the removal of heavy metals. The aim of the study is to investigate the adsorption properties of diatomite. The equilibrium adsorption data were applied to the Langmuir, Freundlich and Dubinin-Radushkevic (D-R) isotherm models. Adsorption experiments were performed under batch process, using Pb (II) initial concentration, pH of solution and contact time as variables. The results demonstrated that the adsorption of Pb (II) was strongly dependent on pH of solution. The effect of pH on adsorption of Pb(II) on diatomite was conducted by varying pH from 2 to 12 at 20 oC. In the pH range of 2.0-4.0, the adsorption percentage increases slightly as the pH increasing. At pH>4, the adsorption percentage decreases with increasing pH because hydrolysis product and the precipitation begin to play an important role in the sorption of Pb (II). At pH4, the maximum adsorption

  1. Fluid mechanics of dynamic stall. II - Prediction of full scale characteristics

    Science.gov (United States)

    Ericsson, L. E.; Reding, J. P.

    1988-01-01

    Analytical extrapolations are made from experimental subscale dynamics to predict full scale characteristics of dynamic stall. The method proceeds by establishing analytic relationships between dynamic and static aerodynamic characteristics induced by viscous flow effects. The method is then validated by predicting dynamic test results on the basis of corresponding static test data obtained at the same subscale flow conditions, and the effect of Reynolds number on the static aerodynamic characteristics are determined from subscale to full scale flow conditions.

  2. Fluid mechanics of dynamic stall. II - Prediction of full scale characteristics

    Science.gov (United States)

    Ericsson, L. E.; Reding, J. P.

    1988-01-01

    Analytical extrapolations are made from experimental subscale dynamics to predict full scale characteristics of dynamic stall. The method proceeds by establishing analytic relationships between dynamic and static aerodynamic characteristics induced by viscous flow effects. The method is then validated by predicting dynamic test results on the basis of corresponding static test data obtained at the same subscale flow conditions, and the effect of Reynolds number on the static aerodynamic characteristics are determined from subscale to full scale flow conditions.

  3. The Health Behavior Schedule-II for Diabetes Predicts Self-Monitoring of Blood Glucose

    Science.gov (United States)

    Frank, Maxwell T.; Cho, Sungkun; Heiby, Elaine M.; Lee, Chun-I; Lahtela, Adrienne L.

    2006-01-01

    The Health Behavior Schedule-II for Diabetes (HBS-IID) is a 27-item questionnaire that was evaluated as a predictor of self-monitoring of blood glucose (SMBG). The HBS-IID was completed by 96 adults with Type 2 diabetes. Recent glycosylated hemoglobin HbA1c and fasting blood glucose results were taken from participants' medical records. Only 31.3%…

  4. Decreasing incidence of disseminated coccidioidomycosis among Piman and San Carlos Apache Indians. A probable environmental basis

    Energy Technology Data Exchange (ETDEWEB)

    Sievers, M.L.; Fisher, J.R.

    1982-10-01

    Among Piman and San Carlos Apache Indians, the rates of disseminated disease and death from coccidioidomycosis have declined 67 percent (p less than 0.001) and 71 percent (p less than 0.01), respectively, between the first and second half of a 22-year observation period (1959-1980), despite a lack of significant change in the rate of primary infection (as determined by the coccidioidin skin test) between the two 11-year periods. The two tribal groups studied comprised 76 percent of the Indian population in the endemic area. More than 90 percent of Pimans and San Carlos Apaches have full Indian heritage, and almost all of them have been lifelong inhabitants of the endemic region. There is no evidence that genetic factors are responsible for the Indians' decrease in mortality and mortality from disseminated coccidioidomycosis. Improvements in housing and working conditions appear to have lessened the exposure to dust laden with C immitis, decreased the size of infecting inoculum, and, thereby, contributed to a decline in disseminated coccidiodomycosis among these native Americans, who have often been considered to have increased susceptibility to this fungal infection. Thus, the outcome of coccidioidal infection in American Indians seems to be largely determined by environmental influences. The possibility of decreasing disseminated disease rates by reducing the inhalation of arthroconidia also has important implications for other ethnic groups.

  5. Sideloading - Ingestion of Large Point Clouds Into the Apache Spark Big Data Engine

    Science.gov (United States)

    Boehm, J.; Liu, K.; Alis, C.

    2016-06-01

    In the geospatial domain we have now reached the point where data volumes we handle have clearly grown beyond the capacity of most desktop computers. This is particularly true in the area of point cloud processing. It is therefore naturally lucrative to explore established big data frameworks for big geospatial data. The very first hurdle is the import of geospatial data into big data frameworks, commonly referred to as data ingestion. Geospatial data is typically encoded in specialised binary file formats, which are not naturally supported by the existing big data frameworks. Instead such file formats are supported by software libraries that are restricted to single CPU execution. We present an approach that allows the use of existing point cloud file format libraries on the Apache Spark big data framework. We demonstrate the ingestion of large volumes of point cloud data into a compute cluster. The approach uses a map function to distribute the data ingestion across the nodes of a cluster. We test the capabilities of the proposed method to load billions of points into a commodity hardware compute cluster and we discuss the implications on scalability and performance. The performance is benchmarked against an existing native Apache Spark data import implementation.

  6. Prediction of the 10-year probability of gastric cancer occurrence in the Japanese population: the JPHC study cohort II.

    Science.gov (United States)

    Charvat, Hadrien; Sasazuki, Shizuka; Inoue, Manami; Iwasaki, Motoki; Sawada, Norie; Shimazu, Taichi; Yamaji, Taiki; Tsugane, Shoichiro

    2016-01-15

    Gastric cancer is a particularly important issue in Japan, where incidence rates are among the highest observed. In this work, we provide a risk prediction model allowing the estimation of the 10-year cumulative probability of gastric cancer occurrence. The study population consisted of 19,028 individuals from the Japanese Public Health Center cohort II who were followed-up from 1993 to 2009. A parametric survival model was used to assess the impact on the probability of gastric cancer of clinical and lifestyle-related risk factors in combination with serum anti-Helicobacter pylori antibody titres and pepsinogen I and pepsinogen II levels. Based on the resulting model, cumulative probability estimates were calculated and a simple risk scoring system was developed. A total of 412 cases of gastric cancer occurred during 270,854 person-years of follow-up. The final model included (besides the biological markers) age, gender, smoking status, family history of gastric cancer and consumption of highly salted food. The developed prediction model showed good predictive performance in terms of discrimination (optimism-corrected c-index: 0.768) and calibration (Nam and d'Agostino's χ(2) test: 14.78; p values = 0.06). Estimates of the 10-year probability of gastric cancer occurrence ranged from 0.04% (0.02, 0.1) to 14.87% (8.96, 24.14) for men and from 0.03% (0.02, 0.07) to 4.91% (2.71, 8.81) for women. In conclusion, we developed a risk prediction model for gastric cancer that combines clinical and biological markers. It might prompt individuals to modify their lifestyle habits, attend regular check-up visits or participate in screening programmes.

  7. CXC chemokine receptor 1 predicts postoperative prognosis and chemotherapeutic benefits for TNM II and III resectable gastric cancer patients.

    Science.gov (United States)

    Cao, Yifan; Liu, Hao; Zhang, Heng; Lin, Chao; Li, Ruochen; Wu, Songyang; Li, He; He, Hongyong; Zhang, Weijuan; Xu, Jiejie

    2017-03-21

    Backround: Abnormal expression of CXC chemokine receptor 1 (CXCR1) has shown the ability to promote tumor angiogensis, invasion and metastasis in several cancers. The purpose of our curret study is to discover the clinical prognostic significance of CXCR1 in resectable gastric cancer. 330 gastric cancer patients who underwent R0 gastrectomy with standard D2 lymphadenectomy at Zhongshan Hospital, Fudan University between 2007 and 2008 were enrolled. CXCR1 expression was evaluated with use of immunohistochemical staining. The relation between CXCR1 expression and clinicopathological features and postoperative prognosis was respectively inspected. In both discovery and validation data sets, CXCR1 high expression indicated poorer overall survival (OS) in TNM II and III patients. Furthermore, multivariate analysis identified CXCR1 expression and TNM stage as two independent prognostic factors for OS. Incorporating CXCR1 expression into current TNM staging system could generate a novel clinical predictive model for gastric cancer, showing better prognostic accuracy with respect to patients' OS. More importantly, TNM II patients with higher CXCR1 expression were shown to significantly benefit from postoperative 5-fluorouracil (5-FU) based adjuvant chemotherapy (ACT). CXCR1 in gastric cancer was identified as an independent adverse prognostic factor. Combining CXCR1 expression with current TNM staging system could lead to better risk stratification and more accurate prognosis for gastric cancer patients. High expression of CXCR1 identified a subgroup of TNM stage II gastric cancer patients who appeared to benefit from 5-FU based ACT.

  8. Geronimo's Kids: A Teacher's Lessons on the Apache Reservation. Elma Dill Russell Spencer Series in the West and Southwest, No. 16.

    Science.gov (United States)

    Ove, Robert S.; Stockel, H. Henrietta

    In 1948, a young and naive Robert Ove arrived at Whitetail, on the Mescalero Apache Reservation, to teach at the Bureau of Indian Affairs day school. Living there were the Chiricahua Apaches--descendants of Geronimo and the survivors of nearly 30 years of incarceration by the U.S. government. With help from Indian historian H. Henrietta Stockel,…

  9. Nonsuicidal Self-Injury in an American Indian Reservation Community: Results from the White Mountain Apache Surveillance System, 2007-2008

    Science.gov (United States)

    Cwik, Mary F.; Barlow, Allison; Tingey, Lauren; Larzelere-Hinton, Francene; Goklish, Novalene; Walkup, John T.

    2011-01-01

    Objective: To describe characteristics and correlates of nonsuicidal self-injury (NSSI) among the White Mountain Apache Tribe. NSSI has not been studied before in American Indian samples despite associated risks for suicide, which disproportionately affect American Indian youth. Method: Apache case managers collected data through a tribally…

  10. Prediction of RNA Polymerase II recruitment, elongation and stalling from histone modification data

    DEFF Research Database (Denmark)

    Chen, Yun; Jørgensen, Mette; Kolde, Raivo

    2011-01-01

    ABSTRACT: BACKGROUND: Initiation and elongation of RNA polymerase II (RNAPII) transcription is regulated by both DNA sequence and chromatin signals. Recent breakthroughs make it possible to measure the chromatin state and activity of core promoters genome-wide, but dedicated computational...... in the gene body, the mRNA production originating from the promoter and finally also the stalling characteristics of RNAPII by considering both quantitative and spatial features of histone modifications around the transcription start site (TSS). As the model framework can also pinpoint the signals...

  11. SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes

    Directory of Open Access Journals (Sweden)

    Atul Kumar

    2017-06-01

    Full Text Available Type II diabetes is a chronic condition that affects the way our body metabolizes sugar. The body's important source of fuel is now becoming a chronic disease all over the world. It is now very necessary to identify the new potential targets for the drugs which not only control the disease but also can treat it. Support vector machines are the classifier which has a potential to make a classification of the discriminatory genes and non-discriminatory genes. SVMRFE a modification of SVM ranks the genes based on their discriminatory power and eliminate the genes which are not involved in causing the disease. A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. To further validate the results pathway study was performed to identify the involvement of the coding genes in type II diabetes. The genes obtained from this study showed a significant involvement in causing the disease, which may be used as a potential drug target.

  12. Predicted Geology of the Pahute Mesa-Oasis Valley Phase II Drilling Initiative

    Energy Technology Data Exchange (ETDEWEB)

    NSTec Environmental Restoration

    2009-04-20

    Pahute Mesa–Oasis Valley (PM-OV) Phase II drilling will occur within an area that encompasses approximately 117 square kilometers (45 square miles) near the center of the Phase I PM-OV hydrostratigraphic framework model area. The majority of the investigation area lies within dissected volcanic terrain between Pahute Mesa on the north and Timber Mountain on the south. This area consists of a complex distribution of volcanic tuff and lava of generally rhyolitic composition erupted from nearby calderas and related vents. Several large buried volcanic structural features control the distribution of volcanic units in the investigation area. The Area 20 caldera, including its structural margin and associated caldera collapse collar, underlies the northeastern portion of the investigation area. The southern half of the investigation area lies within the northwestern portion of the Timber Mountain caldera complex, including portions of the caldera moat and resurgent dome. Another significant structural feature in the area is the west-northwest-trending Northern Timber Mountain moat structural zone, which bisects the northern portion of the investigation area and forms a structural bench. The proposed wells of the UGTA Phase II drilling initiative can be grouped into four generalized volcanic structural domains based on the stratigraphic distribution and structural position of the volcanic rocks in the upper 1,000 meters (3,300 feet) of the crust, a depth that represents the approximate planned total depths of the proposed wells.

  13. FREEZING AND THAWING TIME PREDICTION METHODS OF FOODS II: NUMARICAL METHODS

    Directory of Open Access Journals (Sweden)

    Yahya TÜLEK

    1999-03-01

    Full Text Available Freezing is one of the excellent methods for the preservation of foods. If freezing and thawing processes and frozen storage method are carried out correctly, the original characteristics of the foods can remain almost unchanged over an extended periods of time. It is very important to determine the freezing and thawing time period of the foods, as they strongly influence the both quality of food material and process productivity and the economy. For developing a simple and effectively usable mathematical model, less amount of process parameters and physical properties should be enrolled in calculations. But it is a difficult to have all of these in one prediction method. For this reason, various freezing and thawing time prediction methods were proposed in literature and research studies have been going on.

  14. Angiotensinogen and HLA class II predict bevacizumab response in recurrent glioblastoma patients

    DEFF Research Database (Denmark)

    Urup, Thomas; Michaelsen, Signe Regner; Olsen, Lars Rønn;

    2016-01-01

    Background: Bevacizumab combination therapy is among the most frequently used treatments in recurrent glioblastoma and patients who achieve response to bevacizumab have improved survival as well as quality of life. Accordingly, the aim of this study was to identify predictive biomarkers for bevac......Background: Bevacizumab combination therapy is among the most frequently used treatments in recurrent glioblastoma and patients who achieve response to bevacizumab have improved survival as well as quality of life. Accordingly, the aim of this study was to identify predictive biomarkers...... for bevacizumab response in recurrent glioblastoma patients. Methods: The study included a total of 82 recurrent glioblastoma patients treated with bevacizumab combination therapy whom were both response and biomarker evaluable. Gene expression of tumor tissue was analyzed by using a customized Nano...

  15. Study on Lumped Kinetic Model for FDFCC II. Validation and Prediction of Model

    Institute of Scientific and Technical Information of China (English)

    Wu Feiyue; Weng Huixin; Luo Shixian

    2008-01-01

    On the basis of formulating the 9-lump kinetic model for gasoline catalytic upgrading and the 12-lump kinetic model for heavy oil FCC, this paper is aimed at development of a combined kinetic model for a typical FDFCC process after analyzing the coupled relationship and combination of these two models. The model is also verified by using commercial data, the results of which showed that the model can better predict the product yields and their quality, with the relative errors between the main products of the unit and commercial data being less than five percent. Furthermore, the combined model is used to predict and optimize the operating conditions for gasoline riser and heavy oil riser in FDFCC. So this paper can offer some guidance for the processing of FDFCC and is instructive to model research and development of such multi-reactor process and combined process.

  16. Ground-water exploration in the Bosque del Apache Grant, Socorro County, New Mexico

    Science.gov (United States)

    Cooper, James B.

    1968-01-01

    Test drilling along the Rio Grande in the Bosque del Apache Grant in Socorro County, New Mexico has shown that the area is hydrologically complex and that the quality of the ground water varies from saline to fresh within short distances both laterally and vertically. Nearly all of the riverside land in the Grant is occupied by the migratory waterfowl refuge of the Bosque del Apache National Wildlife Refuge. Potable and near-potable water is obtained from 12 wells in this area that tap sand and gravel, and the wells are capable of yielding 1,000 gallons per minute or more. Stallion Range Center, a military installation on the White Sands Missile Range, about 15 miles east of =he waterfowl refuge, needs about 100,000 gallons per day of potable water. Potable water in large quantities is not known to be available at a location closer to the Center than the refuge area. The Fish and Wildlife Service, which operates the waterfowl refuge, gave permission to White Sands Missile Range to test drill and to develop a supply well in certain areas along the Rio Grande outside the managed lands of the refuge. The U.S. Geological Survey was then asked by White Sands Missile Range to choose locations for test drilling and to monitor drilling and testing of the wells. Between 1963 and 1967 test wells were drilled and a suitable location for a supply well as found. The well would be about 250 feet deep and would tap a body of potable water that is about 100 feet in thickness and is thought to underlie an area of at least 5 square miles. This report contains diagrammatic sections that show the lateral and vertical relation of waters of different quality along the Rio Grande in a part of the Bosque del Apache Grant. Basic data are given in tables; they include records of 7 test wells and 12 high-yield supply wells, and 52 chemical analyses of ground water from the wells.

  17. Constructing Flexible, Configurable, ETL Pipelines for the Analysis of "Big Data" with Apache OODT

    Science.gov (United States)

    Hart, A. F.; Mattmann, C. A.; Ramirez, P.; Verma, R.; Zimdars, P. A.; Park, S.; Estrada, A.; Sumarlidason, A.; Gil, Y.; Ratnakar, V.; Krum, D.; Phan, T.; Meena, A.

    2013-12-01

    A plethora of open source technologies for manipulating, transforming, querying, and visualizing 'big data' have blossomed and matured in the last few years, driven in large part by recognition of the tremendous value that can be derived by leveraging data mining and visualization techniques on large data sets. One facet of many of these tools is that input data must often be prepared into a particular format (e.g.: JSON, CSV), or loaded into a particular storage technology (e.g.: HDFS) before analysis can take place. This process, commonly known as Extract-Transform-Load, or ETL, often involves multiple well-defined steps that must be executed in a particular order, and the approach taken for a particular data set is generally sensitive to the quantity and quality of the input data, as well as the structure and complexity of the desired output. When working with very large, heterogeneous, unstructured or semi-structured data sets, automating the ETL process and monitoring its progress becomes increasingly important. Apache Object Oriented Data Technology (OODT) provides a suite of complementary data management components called the Process Control System (PCS) that can be connected together to form flexible ETL pipelines as well as browser-based user interfaces for monitoring and control of ongoing operations. The lightweight, metadata driven middleware layer can be wrapped around custom ETL workflow steps, which themselves can be implemented in any language. Once configured, it facilitates communication between workflow steps and supports execution of ETL pipelines across a distributed cluster of compute resources. As participants in a DARPA-funded effort to develop open source tools for large-scale data analysis, we utilized Apache OODT to rapidly construct custom ETL pipelines for a variety of very large data sets to prepare them for analysis and visualization applications. We feel that OODT, which is free and open source software available through the Apache

  18. Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis.

    Directory of Open Access Journals (Sweden)

    Matthew Schwede

    Full Text Available Although ovarian cancer is often initially chemotherapy-sensitive, the vast majority of tumors eventually relapse and patients die of increasingly aggressive disease. Cancer stem cells are believed to have properties that allow them to survive therapy and may drive recurrent tumor growth. Cancer stem cells or cancer-initiating cells are a rare cell population and difficult to isolate experimentally. Genes that are expressed by stem cells may characterize a subset of less differentiated tumors and aid in prognostic classification of ovarian cancer. The purpose of this study was the genomic identification and characterization of a subtype of ovarian cancer that has stem cell-like gene expression. Using human and mouse gene signatures of embryonic, adult, or cancer stem cells, we performed an unsupervised bipartition class discovery on expression profiles from 145 serous ovarian tumors to identify a stem-like and more differentiated subgroup. Subtypes were reproducible and were further characterized in four independent, heterogeneous ovarian cancer datasets. We identified a stem-like subtype characterized by a 51-gene signature, which is significantly enriched in tumors with properties of Type II ovarian cancer; high grade, serous tumors, and poor survival. Conversely, the differentiated tumors share properties with Type I, including lower grade and mixed histological subtypes. The stem cell-like signature was prognostic within high-stage serous ovarian cancer, classifying a small subset of high-stage tumors with better prognosis, in the differentiated subtype. In multivariate models that adjusted for common clinical factors (including grade, stage, age, the subtype classification was still a significant predictor of relapse. The prognostic stem-like gene signature yields new insights into prognostic differences in ovarian cancer, provides a genomic context for defining Type I/II subtypes, and potential gene targets which following further

  19. TOUCHSTONE II: a new approach to ab initio protein structure prediction.

    Science.gov (United States)

    Zhang, Yang; Kolinski, Andrzej; Skolnick, Jeffrey

    2003-08-01

    We have developed a new combined approach for ab initio protein structure prediction. The protein conformation is described as a lattice chain connecting C(alpha) atoms, with attached C(beta) atoms and side-chain centers of mass. The model force field includes various short-range and long-range knowledge-based potentials derived from a statistical analysis of the regularities of protein structures. The combination of these energy terms is optimized through the maximization of correlation for 30 x 60,000 decoys between the root mean square deviation (RMSD) to native and energies, as well as the energy gap between native and the decoy ensemble. To accelerate the conformational search, a newly developed parallel hyperbolic sampling algorithm with a composite movement set is used in the Monte Carlo simulation processes. We exploit this strategy to successfully fold 41/100 small proteins (36 approximately 120 residues) with predicted structures having a RMSD from native below 6.5 A in the top five cluster centroids. To fold larger-size proteins as well as to improve the folding yield of small proteins, we incorporate into the basic force field side-chain contact predictions from our threading program PROSPECTOR where homologous proteins were excluded from the data base. With these threading-based restraints, the program can fold 83/125 test proteins (36 approximately 174 residues) with structures having a RMSD to native below 6.5 A in the top five cluster centroids. This shows the significant improvement of folding by using predicted tertiary restraints, especially when the accuracy of side-chain contact prediction is >20%. For native fold selection, we introduce quantities dependent on the cluster density and the combination of energy and free energy, which show a higher discriminative power to select the native structure than the previously used cluster energy or cluster size, and which can be used in native structure identification in blind simulations. These

  20. Overview of the SDSS-IV MaNGA Survey: Mapping nearby Galaxies at Apache Point Observatory

    NARCIS (Netherlands)

    Bundy, Kevin; Bershady, Matthew A.; Law, David R.; Yan, Renbin; Drory, Niv; MacDonald, Nicholas; Wake, David A.; Cherinka, Brian; Sánchez-Gallego, José R.; Weijmans, Anne-Marie; Thomas, Daniel; Tremonti, Christy; Masters, Karen; Coccato, Lodovico; Diamond-Stanic, Aleksandar M.; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco; Bizyaev, Dmitry; Blanc, Guillermo A.; Bland-Hawthorn, Joss; Blanton, Michael R.; Brownstein, Joel R.; Byler, Nell; Cappellari, Michele; Conroy, Charlie; Dutton, Aaron A.; Emsellem, Eric; Etherington, James; Frinchaboy, Peter M.; Fu, Hai; Gunn, James E.; Harding, Paul; Johnston, Evelyn J.; Kauffmann, Guinevere; Kinemuchi, Karen; Klaene, Mark A.; Knapen, Johan H.; Leauthaud, Alexie; Li, Cheng; Lin, Lihwai; Maiolino, Roberto; Malanushenko, Viktor; Malanushenko, Elena; Mao, Shude; Maraston, Claudia; McDermid, Richard M.; Merrifield, Michael R.; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; Parejko, John K.; Sanchez, Sebastian F.; Schlegel, David; Simmons, Audrey; Steele, Oliver; Steinmetz, Matthias; Thanjavur, Karun; Thompson, Benjamin A.; Tinker, Jeremy L.; van den Bosch, Remco C. E.; Westfall, Kyle B.; Wilkinson, David; Wright, Shelley; Xiao, Ting; Zhang, Kai

    2015-01-01

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic stru

  1. The Match between Apache Indians' Culture and Educational Practices Used in Our Schools: From Problems to Solutions

    Science.gov (United States)

    Ingalls, Lawrence; Hammond, Helen

    2007-01-01

    This study examined cultural values and practices of Apache Indian families in regards to child rearing and how culturally responsive our schools' educational practices are with this population of individuals. Findings from this study revealed a potentially negative impact on these students' development and academic achievement. Solutions to…

  2. Overview of the SDSS-IV MaNGA Survey: Mapping nearby Galaxies at Apache Point Observatory

    NARCIS (Netherlands)

    Bundy, Kevin; Bershady, Matthew A.; Law, David R.; Yan, Renbin; Drory, Niv; MacDonald, Nicholas; Wake, David A.; Cherinka, Brian; Sánchez-Gallego, José R.; Weijmans, Anne-Marie; Thomas, Daniel; Tremonti, Christy; Masters, Karen; Coccato, Lodovico; Diamond-Stanic, Aleksandar M.; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco; Bizyaev, Dmitry; Blanc, Guillermo A.; Bland-Hawthorn, Joss; Blanton, Michael R.; Brownstein, Joel R.; Byler, Nell; Cappellari, Michele; Conroy, Charlie; Dutton, Aaron A.; Emsellem, Eric; Etherington, James; Frinchaboy, Peter M.; Fu, Hai; Gunn, James E.; Harding, Paul; Johnston, Evelyn J.; Kauffmann, Guinevere; Kinemuchi, Karen; Klaene, Mark A.; Knapen, Johan H.; Leauthaud, Alexie; Li, Cheng; Lin, Lihwai; Maiolino, Roberto; Malanushenko, Viktor; Malanushenko, Elena; Mao, Shude; Maraston, Claudia; McDermid, Richard M.; Merrifield, Michael R.; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; Parejko, John K.; Sanchez, Sebastian F.; Schlegel, David; Simmons, Audrey; Steele, Oliver; Steinmetz, Matthias; Thanjavur, Karun; Thompson, Benjamin A.; Tinker, Jeremy L.; van den Bosch, Remco C. E.; Westfall, Kyle B.; Wilkinson, David; Wright, Shelley; Xiao, Ting; Zhang, Kai

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic

  3. Prediction and assimilation of surf-zone processes using a Bayesian network: Part II: Inverse models

    Science.gov (United States)

    Plant, Nathaniel G.; Holland, K. Todd

    2011-01-01

    A Bayesian network model has been developed to simulate a relatively simple problem of wave propagation in the surf zone (detailed in Part I). Here, we demonstrate that this Bayesian model can provide both inverse modeling and data-assimilation solutions for predicting offshore wave heights and depth estimates given limited wave-height and depth information from an onshore location. The inverse method is extended to allow data assimilation using observational inputs that are not compatible with deterministic solutions of the problem. These inputs include sand bar positions (instead of bathymetry) and estimates of the intensity of wave breaking (instead of wave-height observations). Our results indicate that wave breaking information is essential to reduce prediction errors. In many practical situations, this information could be provided from a shore-based observer or from remote-sensing systems. We show that various combinations of the assimilated inputs significantly reduce the uncertainty in the estimates of water depths and wave heights in the model domain. Application of the Bayesian network model to new field data demonstrated significant predictive skill (R2 = 0.7) for the inverse estimate of a month-long time series of offshore wave heights. The Bayesian inverse results include uncertainty estimates that were shown to be most accurate when given uncertainty in the inputs (e.g., depth and tuning parameters). Furthermore, the inverse modeling was extended to directly estimate tuning parameters associated with the underlying wave-process model. The inverse estimates of the model parameters not only showed an offshore wave height dependence consistent with results of previous studies but the uncertainty estimates of the tuning parameters also explain previously reported variations in the model parameters.

  4. Automated image processing of Landsat II digital data for watershed runoff prediction

    Science.gov (United States)

    Sasso, R. R.; Jensen, J. R.; Estes, J. E.

    1977-01-01

    Digital image processing of Landsat data from a 230 sq km area was examined as a possible means of generating soil cover information for use in the watershed runoff prediction of Kern County, California. The soil cover information included data on brush, grass, pasture lands and forests. A classification accuracy of 94% for the Landsat-based soil cover survey suggested that the technique could be applied to the watershed runoff estimate. However, problems involving the survey of complex mountainous environments may require further attention

  5. Outcrop Analysis of the Cretaceous Mesaverde Group: Jicarilla Apache Reservation, New Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Ridgley, Jennie; Dunbar, Robin Wright

    2001-04-24

    Field work for this project was conducted during July and April 1998, at which time fourteen measured sections were described and correlated on or adjacent to Jicarilla Apache Reservation lands. A fifteenth section, described east of the main field area, is included in this report, although its distant location precluded use in the correlations and cross sections presented herein. Ground-based photo mosaics were shot for much of the exposed Mesaverde outcrop belt and were used to assist in correlation. Outcrop gamma-ray surveys at six of the fifteen measured sections using a GAD-6 scintillometer was conducted. The raw gamma-ray data are included in this report, however, analysis of those data is part of the ongoing Phase Two of this project.

  6. Extraction of UMLS® Concepts Using Apache cTAKES™ for German Language.

    Science.gov (United States)

    Becker, Matthias; Böckmann, Britta

    2016-01-01

    Automatic information extraction of medical concepts and classification with semantic standards from medical reports is useful for standardization and for clinical research. This paper presents an approach for an UMLS concept extraction with a customized natural language processing pipeline for German clinical notes using Apache cTAKES. The objectives are, to test the natural language processing tool for German language if it is suitable to identify UMLS concepts and map these with SNOMED-CT. The German UMLS database and German OpenNLP models extended the natural language processing pipeline, so the pipeline can normalize to domain ontologies such as SNOMED-CT using the German concepts. For testing, the ShARe/CLEF eHealth 2013 training dataset translated into German was used. The implemented algorithms are tested with a set of 199 German reports, obtaining a result of average 0.36 F1 measure without German stemming, pre- and post-processing of the reports.

  7. Target Selection for the Apache Point Observatory Galactic Evolution Experiment (APOGEE)

    CERN Document Server

    Zasowski, G; Frinchaboy, P M; Majewski, S R; Nidever, D L; Pinto, H J Rocha; Girardi, L; Andrews, B; Chojnowski, S D; Cudworth, K M; Jackson, K; Munn, J; Skrutskie, M F; Beaton, R L; Blake, C H; Covey, K; Deshpande, R; Epstein, C; Fabbian, D; Fleming, S W; Hernandez, A Garcia; Herrero, A; Mahadevan, S; Meszaros, Sz; Schultheis, M; Sellgren, K; Terrien, R; van Saders, J; Prieto, C Allende; Bizyaev, D; Burton, A; Cunha, K; da Costa, L N; Hasselquist, S; Hearty, F; Holtzman, J; Perez, A E Garcia; Maia, M A G; O'Connell, R W; O'Donnell, C; Pinsonneault, M; Santiago, B X; Schiavon, R P; Shetrone, M; Smith, V; Wilson, J C

    2013-01-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE) is a high-resolution infrared spectroscopic survey spanning all Galactic environments (i.e., bulge, disk, and halo), with the principal goal of constraining dynamical and chemical evolution models of the Milky Way. APOGEE takes advantage of the reduced effects of extinction at infrared wavelengths to observe the inner Galaxy and bulge at an unprecedented level of detail. The survey's broad spatial and wavelength coverage enables users of APOGEE data to address numerous Galactic structure and stellar populations issues. In this paper we describe the APOGEE targeting scheme and document its various target classes to provide the necessary background and reference information to analyze samples of APOGEE data with awareness of the imposed selection criteria and resulting sample properties. APOGEE's primary sample consists of ~100,000 red giant stars, selected to minimize observational biases in age and metallicity. We present the methodology and ...

  8. Inequalities in Open Source Software Development: Analysis of Contributor's Commits in Apache Software Foundation Projects.

    Science.gov (United States)

    Chełkowski, Tadeusz; Gloor, Peter; Jemielniak, Dariusz

    2016-01-01

    While researchers are becoming increasingly interested in studying OSS phenomenon, there is still a small number of studies analyzing larger samples of projects investigating the structure of activities among OSS developers. The significant amount of information that has been gathered in the publicly available open-source software repositories and mailing-list archives offers an opportunity to analyze projects structures and participant involvement. In this article, using on commits data from 263 Apache projects repositories (nearly all), we show that although OSS development is often described as collaborative, but it in fact predominantly relies on radically solitary input and individual, non-collaborative contributions. We also show, in the first published study of this magnitude, that the engagement of contributors is based on a power-law distribution.

  9. Next Generation Astronomical Data Processing using Big Data Technologies from the Apache Software Foundation

    Science.gov (United States)

    Mattmann, Chris

    2014-04-01

    In this era of exascale instruments for astronomy we must naturally develop next generation capabilities for the unprecedented data volume and velocity that will arrive due to the veracity of these ground-based sensor and observatories. Integrating scientific algorithms stewarded by scientific groups unobtrusively and rapidly; intelligently selecting data movement technologies; making use of cloud computing for storage and processing; and automatically extracting text and metadata and science from any type of file are all needed capabilities in this exciting time. Our group at NASA JPL has promoted the use of open source data management technologies available from the Apache Software Foundation (ASF) in pursuit of constructing next generation data management and processing systems for astronomical instruments including the Expanded Very Large Array (EVLA) in Socorro, NM and the Atacama Large Milimetre/Sub Milimetre Array (ALMA); as well as for the KAT-7 project led by SKA South Africa as a precursor to the full MeerKAT telescope. In addition we are funded currently by the National Science Foundation in the US to work with MIT Haystack Observatory and the University of Cambridge in the UK to construct a Radio Array of Portable Interferometric Devices (RAPID) that will undoubtedly draw from the rich technology advances underway. NASA JPL is investing in a strategic initiative for Big Data that is pulling in these capabilities and technologies for astronomical instruments and also for Earth science remote sensing. In this talk I will describe the above collaborative efforts underway and point to solutions in open source from the Apache Software Foundation that can be deployed and used today and that are already bringing our teams and projects benefits. I will describe how others can take advantage of our experience and point towards future application and contribution of these tools.

  10. Medium-Range Predictability of Contrail-Cirrus Demonstrated during Experiments Ml-Cirrus and Access-Ii

    Science.gov (United States)

    Schumann, U.

    2015-12-01

    The Contrail Cirrus Prediction model CoCiP (doi:10.5194/gmd-5-543-2012) has been applied quasi operationally to predict contrails for flight planning of ML-CIRRUS (C. Voigt, DLR, et al.) in Europe and for ACCESS II in California (B. Anderson, NASA, et al.) in March-May 2014. The model uses NWP data from ECMWF and past airtraffic data (actual traffic data are used for analysis). The forecasts provided a sequence of hourly forecast maps of contrail cirrus optical depth for 3.5 days, every 12 h. CoCiP has been compared to observations before, e.g. within a global climate-aerosol-contrail model (Schumann, Penner et al., ACPD, 2015, doi:10.5194/acpd-15-19553-2015). Good predictions would allow for climate optimal routing (see, e.g., US patent by Mannstein and Schumann, US 2012/0173147 A1). The predictions are tested by: 1) Local eyewitness reports and photos, 2) satellite observed cloudiness, 3) autocorrelation analysis of predictions for various forecast periods, 4) comparisons of computed with observed optical depth from COCS (doi:10.5194/amt-7-3233-2014, 2014) by IR METEOSAT-SEVIRI observations over Europe. The results demonstrate medium-range predictability of contrail cirrus to a useful degree for given traffic, soot emissions, and high-quality NWP data. A growing set of satellite, Lidar, and in-situ data from ML-CIRRUS and ACCENT are becoming available and will be used to further test the forecast quality. The autocorrelation of optical depth predictions is near 70% for 3-d forecasts for Europe (outside times with high Sahara dust loads), and only slightly smaller for continental USA. Contrail cirrus is abundant over Europe and USA. More than 1/3 of all cirrus measured with the research aircraft HALO during ML-CIRRUS was impacted by contrails. The radiative forcing (RF) is strongly daytime and ambience dependent. The net annual mean RF, based on our global studies, may reach up to 0.08 W/m2 globally, and may well exceed 1 W/m2 regionally, with maximum over Europe

  11. TSSPlant: a new tool for prediction of plant Pol II promoters

    KAUST Repository

    Shahmuradov, Ilham A.

    2017-01-13

    Our current knowledge of eukaryotic promoters indicates their complex architecture that is often composed of numerous functional motifs. Most of known promoters include multiple and in some cases mutually exclusive transcription start sites (TSSs). Moreover, TSS selection depends on cell/tissue, development stage and environmental conditions. Such complex promoter structures make their computational identification notoriously difficult. Here, we present TSSPlant, a novel tool that predicts both TATA and TATA-less promoters in sequences of a wide spectrum of plant genomes. The tool was developed by using large promoter collections from ppdb and PlantProm DB. It utilizes eighteen significant compositional and signal features of plant promoter sequences selected in this study, that feed the artificial neural network-based model trained by the backpropagation algorithm. TSSPlant achieves significantly higher accuracy compared to the next best promoter prediction program for both TATA promoters (MCC≃0.84 and F1-score≃0.91 versus MCC≃0.51 and F1-score≃0.71) and TATA-less promoters (MCC≃0.80, F1-score≃0.89 versus MCC≃0.29 and F1-score≃0.50). TSSPlant is available to download as a standalone program at http://www.cbrc.kaust.edu.sa/download/.

  12. Traveling waves in trimer granular lattice II: Asymptotic prediction of weakly attenuated pulses

    Science.gov (United States)

    Shiffer, A.; Jayaprakash, K. R.; Starosvetsky, Y.

    2017-02-01

    In the present study we consider the impulsive response of perfectly aligned, uncompressed, tri-atomic (trimer) granular lattice. In this study, we demonstrate that under particular choice of the system parameters - impulsively loaded, trimer granular lattice can support formation of highly localized, weakly attenuated pulses. These pulses are manifested by the completely non-symmetric wave profiles and can be attributed to the special family of solitary like waves forming in the non-homogenous, periodic trimer granular lattice in the state of acoustic vacuum. Using the recently developed analytical procedure based on the singular, multi-scale perturbation analysis, we derive a simplified reduced order model predicting the special regions in the space of the system parameters corresponding to the formation of the weakly attenuated pulses. Predictions of the asymptotical model are found to be in very good agreement with the results of numerical simulations of the full trimer granular lattice. From a practical point of view, these results can have important implications in complex, structural optimization problems of wave manipulation in the repetitive granular metamaterials.

  13. Development and Application of Benchmark Examples for Mode II Static Delamination Propagation and Fatigue Growth Predictions

    Science.gov (United States)

    Krueger, Ronald

    2011-01-01

    The development of benchmark examples for static delamination propagation and cyclic delamination onset and growth prediction is presented and demonstrated for a commercial code. The example is based on a finite element model of an End-Notched Flexure (ENF) specimen. The example is independent of the analysis software used and allows the assessment of the automated delamination propagation, onset and growth prediction capabilities in commercial finite element codes based on the virtual crack closure technique (VCCT). First, static benchmark examples were created for the specimen. Second, based on the static results, benchmark examples for cyclic delamination growth were created. Third, the load-displacement relationship from a propagation analysis and the benchmark results were compared, and good agreement could be achieved by selecting the appropriate input parameters. Fourth, starting from an initially straight front, the delamination was allowed to grow under cyclic loading. The number of cycles to delamination onset and the number of cycles during delamination growth for each growth increment were obtained from the automated analysis and compared to the benchmark examples. Again, good agreement between the results obtained from the growth analysis and the benchmark results could be achieved by selecting the appropriate input parameters. The benchmarking procedure proved valuable by highlighting the issues associated with choosing the input parameters of the particular implementation. Selecting the appropriate input parameters, however, was not straightforward and often required an iterative procedure. Overall the results are encouraging, but further assessment for mixed-mode delamination is required.

  14. Blast Noise Prediction. Volume II. BNOISE 3.2 Computer Program Description and Program Listing.

    Science.gov (United States)

    1981-03-01

    spec:itied grid si/c For example, it the x \\alues ofI hounds \\A~ere 20,000 and 4 *Ii1iii ind d i < - vii si/e~ 2000t. thein ihe nev, hounds; ire 20000 ) and...Tor he iied InI L,1LUiing he Itil S I I *I hIre C u ’cFrt I ~ ~ c (hi)I IMJ CS,\\Th can he LISedL Ir t iICUlitirig hW inilti CXjIMSHIf depend1InIfg 01n...0 C - 0 00 0 * 0 NCU’C 04 0 C0 L.LL.J04N0U𔃺 a00W�NN01iCCL.aCLLJ-4U’C.f’-...LO .400C00~- N V ’C SOON CC C P00 ZOU’CONON 20000 -.0,.iOZCZ.W󈧄-.ZN

  15. Mitochondrial cytochrome c oxidase subunit II variations predict adverse prognosis in cytogenetically normal acute myeloid leukaemia.

    Science.gov (United States)

    Silkjaer, Trine; Nyvold, Charlotte Guldborg; Juhl-Christensen, Caroline; Hokland, Peter; Nørgaard, Jan Maxwell

    2013-10-01

    Alterations in the two catalytic genes cytochrome c oxidase subunits I and II (COI and COII) have recently been suggested to have an adverse impact on prognosis in patients with acute myeloid leukaemia (AML). In order to explore this in further detail, we sequenced these two mitochondrial genes in diagnostic bone marrow or blood samples in 235 patients with AML. In 37 (16%) patients, a non-synonymous variation in either COI or COII could be demonstrated. No patients harboured both COI and COII non-synonymous variations. Twenty-four (10%) patients had non-synonymous variations in COI, whereas 13 (6%) patients had non-synonymous variations in COII. The COI and COII are essential subunits of cytochrome c oxidase that is the terminal enzyme in the oxidative phosphorylation complexes. In terms of disease course, we observed that in patients with a normal cytogenetic analysis at disease presentation (CN-AML) treated with curative intent, the presence of a non-synonymous variation in the COII was an adverse prognostic marker for both overall survival and disease-free survival (DFS) in both univariate (DFS; hazard ratio (HR) 4.4, P = 0.006) and multivariate analyses (DFS; HR 7.2, P = 0.001). This is the first demonstration of a mitochondrial aberration playing an adverse prognostic role in adult AML, and we argue that its role as a potentially novel adverse prognostic marker in the subset of CN-AML should be explored further.

  16. Making oxidation potentials predictable: Coordination of additives applied to the electronic fine tuning of an iron(II) complex

    KAUST Repository

    Haslinger, Stefan

    2014-11-03

    This work examines the impact of axially coordinating additives on the electronic structure of a bioinspired octahedral low-spin iron(II) N-heterocyclic carbene (Fe-NHC) complex. Bearing two labile trans-acetonitrile ligands, the Fe-NHC complex, which is also an excellent oxidation catalyst, is prone to axial ligand exchange. Phosphine- and pyridine-based additives are used for substitution of the acetonitrile ligands. On the basis of the resulting defined complexes, predictability of the oxidation potentials is demonstrated, based on a correlation between cyclic voltammetry experiments and density functional theory calculated molecular orbital energies. Fundamental insights into changes of the electronic properties upon axial ligand exchange and the impact on related attributes will finally lead to target-oriented manipulation of the electronic properties and consequently to the effective tuning of the reactivity of bioinspired systems.

  17. Design and verification of controllers for longitudinal oscillations using optimal control theory and numerical simulation: Predictions for PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Hindi, H.; Prabhakar, S.; Fox, J.; Teytelman, D.

    1997-12-01

    The authors present a technique for the design and verification of efficient bunch-by-bunch controllers for damping longitudinal multibunch instabilities. The controllers attempt to optimize the use of available feedback amplifier power--one of the most expensive components of a feedback system--and define the limits of closed loop system performance. The design technique alternates between analytic computation of single bunch optimal controllers and verification on a multibunch numerical simulator. The simulator identifies unstable coupled bunch modes and predicts their growth and damping rates. The results from the simulator are shown to be in reasonable agreement with analytical calculations based on the single bunch model. The technique is then used to evaluate the performance of a variety of controllers proposed for PEP-II.

  18. Using DFT methodology for more reliable predictive models: Design of inhibitors of Golgi α-Mannosidase II.

    Science.gov (United States)

    Bobovská, Adela; Tvaroška, Igor; Kóňa, Juraj

    2016-05-01

    Human Golgi α-mannosidase II (GMII), a zinc ion co-factor dependent glycoside hydrolase (E.C.3.2.1.114), is a pharmaceutical target for the design of inhibitors with anti-cancer activity. The discovery of an effective inhibitor is complicated by the fact that all known potent inhibitors of GMII are involved in unwanted co-inhibition with lysosomal α-mannosidase (LMan, E.C.3.2.1.24), a relative to GMII. Routine empirical QSAR models for both GMII and LMan did not work with a required accuracy. Therefore, we have developed a fast computational protocol to build predictive models combining interaction energy descriptors from an empirical docking scoring function (Glide-Schrödinger), Linear Interaction Energy (LIE) method, and quantum mechanical density functional theory (QM-DFT) calculations. The QSAR models were built and validated with a library of structurally diverse GMII and LMan inhibitors and non-active compounds. A critical role of QM-DFT descriptors for the more accurate prediction abilities of the models is demonstrated. The predictive ability of the models was significantly improved when going from the empirical docking scoring function to mixed empirical-QM-DFT QSAR models (Q(2)=0.78-0.86 when cross-validation procedures were carried out; and R(2)=0.81-0.83 for a testing set). The average error for the predicted ΔGbind decreased to 0.8-1.1kcalmol(-1). Also, 76-80% of non-active compounds were successfully filtered out from GMII and LMan inhibitors. The QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and force field methods reached their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for GMII drug developments.

  19. The flow of a thin liquid film on a stationary and rotating disk. II - Theoretical prediction

    Science.gov (United States)

    Rahman, M. M.; Faghri, A.; Hankey, W. L.

    1990-01-01

    The existing theoretical models are improved and a systematic procedure to compute the free surface flow of a thin liquid film is suggested. The solutions for axisymmetric radial flow on a stationary horizontal disk and for the disk rotating around its axis are presented. The theoretical predictions are compared with the experimental data presented in Part I of this report. The analysis shows results for both supercritical and subcritical flows and the flow structure in the vicinity of a hydraulic jump which isolates these two flow types. The detailed flow structure in a hydraulic jump was computed and shown to contain regions of separation including a 'surface roller'. The effects of surface tension are found to be important near the outer edge of the disk where the fluid experiences a free fall. At other locations, the surface tension is negligible. For a rotating disk, the frictional resistance in the angular direction is found to be as important as that in the radial direction.

  20. Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus

    DEFF Research Database (Denmark)

    Pena, Michelle J; Heinzel, Andreas; Rossing, Peter;

    2016-01-01

    validated in patients with type 1 diabetes and macroalbuminuria (n = 50) treated with losartan 100 mg/day. Molecular process analysis was performed to link metabolites to molecular mechanisms contributing to ARB response. RESULTS: In discovery, median change in urinary albumin excretion (UAE) was -42 % [Q1...... to ARBs in patients with diabetes mellitus and micro- or macroalbuminuria. METHODS: Liquid chromatography-tandem mass spectrometry metabolomics was performed on serum samples. Data from patients with type 2 diabetes and microalbuminuria (n = 49) treated with irbesartan 300 mg/day were used for discovery....... LASSO and ridge regression were performed to develop the classifier. Improvement in albuminuria response prediction was assessed by calculating differences in R(2) between a reference model of clinical parameters and a model with clinical parameters and the classifier. The classifier was externally...

  1. A new model to predict weak-lensing peak counts II. Parameter constraint strategies

    CERN Document Server

    Lin, Chieh-An

    2015-01-01

    Peak counts have been shown to be an excellent tool to extract the non-Gaussian part of the weak lensing signal. Recently, we developped a fast stochastic forward model to predict weak-lensing peak counts. Our model is able to reconstruct the underlying distribution of observables for analyses. In this work, we explore and compare various strategies for constraining parameter using our model, focusing on the matter density $\\Omega_\\mathrm{m}$ and the density fluctuation amplitude $\\sigma_8$. First, we examine the impact from the cosmological dependency of covariances (CDC). Second, we perform the analysis with the copula likelihood, a technique which makes a weaker assumption compared to the Gaussian likelihood. Third, direct, non-analytic parameter estimations are applied using the full information of the distribution. Fourth, we obtain constraints with approximate Bayesian computation (ABC), an efficient, robust, and likelihood-free algorithm based on accept-reject sampling. We find that neglecting the CDC ...

  2. Transient PVT measurements and model predictions for vessel heat transfer. Part II.

    Energy Technology Data Exchange (ETDEWEB)

    Felver, Todd G.; Paradiso, Nicholas Joseph; Winters, William S., Jr.; Evans, Gregory Herbert; Rice, Steven F.

    2010-07-01

    Part I of this report focused on the acquisition and presentation of transient PVT data sets that can be used to validate gas transfer models. Here in Part II we focus primarily on describing models and validating these models using the data sets. Our models are intended to describe the high speed transport of compressible gases in arbitrary arrangements of vessels, tubing, valving and flow branches. Our models fall into three categories: (1) network flow models in which flow paths are modeled as one-dimensional flow and vessels are modeled as single control volumes, (2) CFD (Computational Fluid Dynamics) models in which flow in and between vessels is modeled in three dimensions and (3) coupled network/CFD models in which vessels are modeled using CFD and flows between vessels are modeled using a network flow code. In our work we utilized NETFLOW as our network flow code and FUEGO for our CFD code. Since network flow models lack three-dimensional resolution, correlations for heat transfer and tube frictional pressure drop are required to resolve important physics not being captured by the model. Here we describe how vessel heat transfer correlations were improved using the data and present direct model-data comparisons for all tests documented in Part I. Our results show that our network flow models have been substantially improved. The CFD modeling presented here describes the complex nature of vessel heat transfer and for the first time demonstrates that flow and heat transfer in vessels can be modeled directly without the need for correlations.

  3. Development of a mortality prediction formula due to sepsis/severe sepsis in a medical intensive care unit

    Directory of Open Access Journals (Sweden)

    Anant Mohan

    2015-01-01

    Full Text Available Background: Although sepsis is one of the leading causes of mortality in hospitalized patients, information regarding early predictive factors for mortality and morbidity is limited. Materials and Methods: Patients fulfilling the Infectious Disease Society of America criteria of sepsis within the medical intensive care unit (ICU were included over two years. Apart from baseline hematological, biochemical, and metabolic parameters, Acute Physiology and Chronic Health Evaluation II (APACHE II, Simplified Acute Physiology Score II and III (SAPS II and SAPS III, and Sequential Organ Function Assessment (SOFA scores were calculated on day 1 of admission. Patients were followed till death or discharge from the ICU. Results: One hundred patients were enrolled over two years (54% males. The overall mortality was 53%, (69.5% in females, 38.8% in males (P < 0.01. Mortality was 65.7%, 55.7%, and 33.3% in patients with septic shock, severe sepsis, and sepsis, respectively. Patients who died were significantly older than the survivors (mean age, 57.37 ± 20.42 years and 44.29 ± 15.53 years respectively, P < 0.01. Nonsurvivors were significantly more anemic and had higher APACHE II, SAPS II, SAPS III, and SOFA scores. The presence of acute respiratory distress syndrome and renal dysfunction were associated with higher mortality (75% and 70.2%, respectively. There was no significant difference in the duration of mechanical ventilation or ICU stay between survivors and nonsurvivors. On multivariate analysis, significant predictors of mortality with odds ratio greater than 2 included the presence of anemia, SAPS II score greater than 35, SAPS III score greater than 47, and SOFA score greater than 6 at day 1 of admission. Conclusion: Several demographic and laboratory parameters as well as composite critical illness scoring systems are reliable early predictors of mortality in sepsis. A sepsis mortality prediction formula (AIIMS Sepsis Score based on SAPS II

  4. Clinical Significance of AFP and PIVKA-II Responses for Monitoring Treatment Outcomes and Predicting Prognosis in Patients with Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Hana Park

    2013-01-01

    Full Text Available Aim. Recently, the utility of tumor markers in the hepatocellular carcinoma (HCC field has received a good deal of attention. Here, we review and summarize the results of studies on the roles played by the α-fetoprotein (AFP and prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II responses in terms of the monitoring of outcomes and prediction of prognosis after various HCC treatments. Methods. Studies lodged in PUBMED and that satisfied our inclusion criteria were reviewed. Results. We reviewed 12 studies measuring both AFP and PIVKA-II responses in HCC patients treated in various ways. The results are presented by treatment modality. Conclusion. Measurement of AFP and PIVKA II marker levels before and after HCC treatment is clinically useful in monitoring of treatment outcomes and prognosis and in predicting recurrence and survival.

  5. Modelling air pollution for epidemiologic research--part II: predicting temporal variation through land use regression.

    Science.gov (United States)

    Mölter, A; Lindley, S; de Vocht, F; Simpson, A; Agius, R

    2010-12-01

    Over recent years land use regression (LUR) has become a frequently used method in air pollution exposure studies, as it can model intra-urban variation in pollutant concentrations at a fine spatial scale. However, very few studies have used the LUR methodology to also model the temporal variation in air pollution exposure. The aim of this study is to estimate annual mean NO(2) and PM(10) concentrations from 1996 to 2008 for Greater Manchester using land use regression models. The results from these models will be used in the Manchester Asthma and Allergy Study (MAAS) birth cohort to determine health effects of air pollution exposure. The Greater Manchester LUR model for 2005 was recalibrated using interpolated and adjusted NO(2) and PM(10) concentrations as dependent variables for 1996-2008. In addition, temporally resolved variables were available for traffic intensity and PM(10) emissions. To validate the resulting LUR models, they were applied to the locations of automatic monitoring stations and the estimated concentrations were compared against measured concentrations. The 2005 LUR models were successfully recalibrated, providing individual models for each year from 1996 to 2008. When applied to the monitoring stations the mean prediction error (MPE) for NO(2) concentrations for all stations and years was -0.8μg/m³ and the root mean squared error (RMSE) was 6.7μg/m³. For PM(10) concentrations the MPE was 0.8μg/m³ and the RMSE was 3.4μg/m³. These results indicate that it is possible to model temporal variation in air pollution through LUR with relatively small prediction errors. It is likely that most previous LUR studies did not include temporal variation, because they were based on short term monitoring campaigns and did not have historic pollution data. The advantage of this study is that it uses data from an air dispersion model, which provided concentrations for 2005 and 2010, and therefore allowed extrapolation over a longer time period

  6. The Predicted Proteomic Network Associated with the Antiarthritic Action of Qingfu Guanjieshu in Collagen-II-Induced Arthritis in Rats

    Directory of Open Access Journals (Sweden)

    Ting Yu Wang

    2013-01-01

    Full Text Available Qingfu Guanjieshu (QFGJS is an herbal preparation for treating rheumatoid arthritis (RA. Previous studies revealed that QFGJS significantly inhibited experimental arthritis and acute inflammation, accompanied by reduction of proinflammatory cytokines and elevation of anti-inflammatory cytokines. This study aims to identify the targeted proteins and predict the proteomic network associated with the drug action of QFGJS by using 2D gel and MALDI-TOF-MS/MS techniques. Thirty female Wistar rats were evenly grouped as normal and vehicle- and QFGJS-treated CIA rats. The antiarthritic effect of QFGJS was examined with a 19-day treatment course, and the knee synovial tissues of animals from each group were obtained for 2D gel and MALDI-TOF-MS/MS analysis. Results showed that QFGJS significantly ameliorated collagen II-induced arthritis when administrated at 2.8 g/kg body weight for 19 days. 2D gel image analysis revealed 89 differentially expressed proteins in the synovial tissues among the normal and vehicle- and QFGJS-treated CIA rats from over 1000 proteins of which 63 proteins were identified by MALDI-TOF-MS/MS analysis, and 32 proteins were included for classification of functions using Gene Ontology (GO method. Finally, 14 proteins were analyzed using bioinformatics, and a predicted proteomic network related to the anti-arthritic effect of QFGJS was established, and Pgk1 plays a central role.

  7. The HART II International Workshop: An Assessment of the State-of-the-Art in Comprehensive Code Prediction

    Science.gov (United States)

    vanderWall, Berend G.; Lim, Joon W.; Smith, Marilyn J.; Jung, Sung N.; Bailly, Joelle; Baeder, James D.; Boyd, D. Douglas, Jr.

    2013-01-01

    Significant advancements in computational fluid dynamics (CFD) and their coupling with computational structural dynamics (CSD, or comprehensive codes) for rotorcraft applications have been achieved recently. Despite this, CSD codes with their engineering level of modeling the rotor blade dynamics, the unsteady sectional aerodynamics and the vortical wake are still the workhorse for the majority of applications. This is especially true when a large number of parameter variations is to be performed and their impact on performance, structural loads, vibration and noise is to be judged in an approximate yet reliable and as accurate as possible manner. In this article, the capabilities of such codes are evaluated using the HART II International Workshop database, focusing on a typical descent operating condition which includes strong blade-vortex interactions. A companion article addresses the CFD/CSD coupled approach. Three cases are of interest: the baseline case and two cases with 3/rev higher harmonic blade root pitch control (HHC) with different control phases employed. One setting is for minimum blade-vortex interaction noise radiation and the other one for minimum vibration generation. The challenge is to correctly predict the wake physics-especially for the cases with HHC-and all the dynamics, aerodynamics, modifications of the wake structure and the aero-acoustics coming with it. It is observed that the comprehensive codes used today have a surprisingly good predictive capability when they appropriately account for all of the physics involved. The minimum requirements to obtain these results are outlined.

  8. Prediction of Peptide Binding to Major Histocompatibility II Receptors with Molecular Mechanics and Semi-Empirical Quantum Mechanics Methods

    Directory of Open Access Journals (Sweden)

    James A Platts

    2012-02-01

    Full Text Available Methods for prediction of the binding of peptides to major histocompatibility complex (MHC II receptors are examined, using literature values of IC50 as a benchmark. Two sets of IC50 data for closely structurally related peptides based on hen egg lysozyme (HEL and myelin basic protein (MBP are reported first. This shows that methods based on both molecular mechanics and semi-empirical quantum mechanics can predict binding with good-to-reasonable accuracy, as long as a suitable method for estimation of solvation effects is included. A more diverse set of 22 peptides bound to HLA-DR1 provides a tougher test of such methods, especially since no crystal structure is available for these peptide-MHC complexes. We therefore use sequence based methods such as SYFPEITHI and SVMHC to generate possible binding poses, using a consensus approach to determine the most likely anchor residues, which are then mapped onto the crystal structure of an unrelated peptide bound to the same receptor. This analysis shows that the MM/GBVI method performs particularly well, as does the AMBER94 forcefield with Born solvation model. Indeed, MM/GBVI can be used as an alternative to sequence based methods in generating binding poses, leading to still better accuracy.

  9. Development and Application of Benchmark Examples for Mixed-Mode I/II Quasi-Static Delamination Propagation Predictions

    Science.gov (United States)

    Krueger, Ronald

    2012-01-01

    The development of benchmark examples for quasi-static delamination propagation prediction is presented. The example is based on a finite element model of the Mixed-Mode Bending (MMB) specimen for 50% mode II. The benchmarking is demonstrated for Abaqus/Standard, however, the example is independent of the analysis software used and allows the assessment of the automated delamination propagation prediction capability in commercial finite element codes based on the virtual crack closure technique (VCCT). First, a quasi-static benchmark example was created for the specimen. Second, starting from an initially straight front, the delamination was allowed to propagate under quasi-static loading. Third, the load-displacement as well as delamination length versus applied load/displacement relationships from a propagation analysis and the benchmark results were compared, and good agreement could be achieved by selecting the appropriate input parameters. The benchmarking procedure proved valuable by highlighting the issues associated with choosing the input parameters of the particular implementation. Overall, the results are encouraging, but further assessment for mixed-mode delamination fatigue onset and growth is required.

  10. Efficacy of PIVKA-II in prediction and early detection of hepatocellular carcinoma: a nested case-control study in Chinese patients

    OpenAIRE

    Rentao Yu; Xiaomei Xiang; Zhaoxia Tan; Yi Zhou; Haoliang Wang; Guohong Deng

    2016-01-01

    Prognosis of hepatocellular carcinoma (HCC) remains unsatisfying due to a lack of early detecting methods. Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) has been proved to be an efficient biomarker for HCC. However, the predicting efficacy of PIVKA-II has barely been reported. In the Hepatitis Biobank of Southwest Hospital (HBS) cohort at Southwest Hospital, we did a two-stage nested case-control study. Totally, 45 HCC cases versus 138 matched controls were enrolled to comp...

  11. X-Ray Irradiated Protoplanetary Disk Atmospheres. II. Predictions from Models in Hydrostatic Equilibrium

    Science.gov (United States)

    Ercolano, Barbara; Clarke, Cathie J.; Drake, Jeremy J.

    2009-07-01

    We present new models for the X-ray photoevaporation of circumstellar disks which suggest that the resulting mass loss (occurring mainly over the radial range 10-40 AU) may be the dominant dispersal mechanism for gas around low-mass pre-main-sequence stars, contrary to the conclusions of previous workers. Our models combine use of the MOCASSIN Monte Carlo radiative transfer code and a self-consistent solution of the hydrostatic structure of the irradiated disk. We estimate the resulting photoevaporation rates assuming sonic outflow at the surface where the gas temperature equals the local escape temperature and derive mass-loss rates of ~10-9 M sun yr-1, typically a factor of 2-10 times lower than the corresponding rates in our previous work where we did not adjust the density structure of the irradiated disk. The somewhat lower rates, and the fact that mass loss is concentrated toward slightly smaller radii, result from the puffing up of the heated disk at a few AU which partially screens the disk at tens of AU. Our mass-loss fluxes agree with those of Alexander et al. but we differ from Alexander et al. in our assessment of the overall significance of X-ray photoevaporation, given the large disk radii (and hence emitting area) associated with X-ray-driven winds. Gorti & Hollenbach, on the other hand, predict considerably lower mass-loss fluxes than either Alexander et al. or ourselves and we discuss possible reasons for this difference. We highlight the fact that X-ray photoevaporation has two generic advantages for disk dispersal compared with photoevaporation by extreme ultraviolet (EUV) photons that are only modestly beyond the Lyman limit: the demonstrably large X-ray fluxes of young stars even after they have lost their disks and the fact that X-rays are effective at penetrating much larger columns of material close to the star. We however stress that our X-ray-driven mass-loss rates are considerably more uncertain than the corresponding rates for EUV

  12. Predicting Pattern Tooling and Casting Dimensions for Investment Casting - Phase II

    Energy Technology Data Exchange (ETDEWEB)

    Sabau, Adrian S [ORNL

    2005-09-01

    The investment casting process allows the production of complex-shape parts and close dimensional tolerances. One of the most important phases in the investment casting process is the design of the pattern die. Pattern dies are used to create wax patterns by injecting wax into dies. The wax patterns are used to create a ceramic shell by the application of a series of ceramic coatings, and the alloy is cast into the dewaxed shell mold (Fig. 1.1). However, the complexity of shape and the close dimensional tolerances required in the final casting make it difficult to determine tooling dimensions. The final linear dimension of the casting depends on the cumulative effects of the linear expansions or contractions in each step of the investment casting process (Fig. 1.2). In most cases, the mold geometry or cores restrict the shrinkage of the pattern or the cast part, and the final casting dimensions may be affected by time-dependent processes such as viscoelastic deformation of the wax, and viscoplastic creep and plastic deformations of the shell and alloy. The pattern die is often reworked several times to produce castings whose dimensions are within acceptable tolerances. To date, investment casting technology has been based on hands-on training and experience. Technical literature is limited to experimental, phenomenological studies aimed at obtaining empirical correlations for quick and easy application in industry. The goal of this project was to predict casting dimensions for investment castings in order to meet blueprint nominal during the first casting run. Several interactions have to be considered in a coupled manner to determine the shrinkage factors: these are the die-wax, wax-shell, and shell-alloy interactions (as illustrated in Fig. 1.3). In this work, the deformations of the die-wax and shell-alloy systems were considered in a coupled manner, while the coupled deformation of the wax-shell system was not considered. Future work is needed in order to

  13. A Comparison of a Machine Learning Model with EuroSCORE II in Predicting Mortality after Elective Cardiac Surgery: A Decision Curve Analysis.

    Science.gov (United States)

    Allyn, Jérôme; Allou, Nicolas; Augustin, Pascal; Philip, Ivan; Martinet, Olivier; Belghiti, Myriem; Provenchere, Sophie; Montravers, Philippe; Ferdynus, Cyril

    2017-01-01

    The benefits of cardiac surgery are sometimes difficult to predict and the decision to operate on a given individual is complex. Machine Learning and Decision Curve Analysis (DCA) are recent methods developed to create and evaluate prediction models. We conducted a retrospective cohort study using a prospective collected database from December 2005 to December 2012, from a cardiac surgical center at University Hospital. The different models of prediction of mortality in-hospital after elective cardiac surgery, including EuroSCORE II, a logistic regression model and a machine learning model, were compared by ROC and DCA. Of the 6,520 patients having elective cardiac surgery with cardiopulmonary bypass, 6.3% died. Mean age was 63.4 years old (standard deviation 14.4), and mean EuroSCORE II was 3.7 (4.8) %. The area under ROC curve (IC95%) for the machine learning model (0.795 (0.755-0.834)) was significantly higher than EuroSCORE II or the logistic regression model (respectively, 0.737 (0.691-0.783) and 0.742 (0.698-0.785), p machine learning model, in this monocentric study, has a greater benefit whatever the probability threshold. According to ROC and DCA, machine learning model is more accurate in predicting mortality after elective cardiac surgery than EuroSCORE II. These results confirm the use of machine learning methods in the field of medical prediction.

  14. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance.

    Science.gov (United States)

    Weyer, C; Foley, J E; Bogardus, C; Tataranni, P A; Pratley, R E

    2000-12-01

    Cross-sectional studies indicate that enlarged subcutaneous abdominal adipocyte size is associated with hyperinsulinaemia, insulin resistance and glucose intolerance. To further explore the pathophysiological significance of these associations, we examined prospectively whether enlarged subcutaneous abdominal adipocyte size predicts Type II (non-insulin-dependent) diabetes mellitus. Body composition (hydrodensitometry), mean subcutaneous abdominal adipocyte size (fat biopsy), insulin sensitivity (hyperinsulinaemic clamp) and the acute insulin secretory response (25-g i.v. GTT) were assessed in 280 Pima Indians with either normal (NGT), impaired (IGT) or diabetic glucose tolerance (75-g OGTT). Subjects with NGT were then followed prospectively. After adjusting for age, sex and per cent body fat, mean subcutaneous abdominal adipocyte size was 19% and 11% higher in subjects with diabetes and IGT, compared with those with NGT (p < 0.001). Insulin sensitivity was inversely correlated with mean subcutaneous abdominal adipocyte size (r = -0.53, p < 0.0001), even after adjusting for per cent body fat (r = -0.31, p < 0.001). In 108 NGT subjects followed over 9.3 +/- 4.1 years (33 of whom developed diabetes), enlarged mean subcutaneous abdominal adipocyte size but not high per cent body fat, was an independent predictor of diabetes, in addition to a low insulin sensitivity and acute insulin secretory response [relative hazard 10th vs 90th centile (95% CI): 5.8 (1.7-19.6), p < 0.005]. In 28 NGT subjects with a 9% weight gain over 2.7 +/- 1.3 years, changes in insulin sensitivity were inversely and independently related to changes in mean subcutaneous abdominal adipocyte size and per cent body fat. Although enlarged mean subcutaneous abdominal adipocyte size is associated with insulin resistance cross-sectionally, prospectively, both abnormalities are independent and additive predictors of Type II diabetes.

  15. A predictive genetic signature for response to fluoropyrimidine-based neoadjuvant chemoradiation in clinical Stage II and III rectal cancer

    Directory of Open Access Journals (Sweden)

    Jason eChan

    2013-11-01

    Full Text Available PurposePreoperative chemoradiation is currently the standard of care for patients with clinical stage II and III rectal cancer but only about 45% of patients achieve tumor downstaging and less than 20% of patients achieve a pathologic complete response. Better methods to stratify patients according to potential neoadjuvant treatment response are needed. We used microarray analysis to identify a genetic signature that correlates with a pathological complete response to neoadjuvant chemoradiation. We performed a gene network analysis to identify potential signaling pathways involved in determining response to neoadjuvant treatment.Patients and MethodsWe identified 31 T3-4 N0-1 rectal cancer patients who were treated with neoadjuvant fluorouracil-based chemoradiation. 8 patients were identified to have achieved a pathological complete response to treatment while 23 patients did not. mRNA expression was analyzed using cDNA microarrays. The correlation between mRNA expression and pathological complete response from pre-treatment tumor biopsies was determined. Gene network analysis was performed for the genes represented by the predictive signature.ResultsA genetic signature represented by expression levels of the 3 genes EHBP1, STAT1, and GAPDH was found to correlate with a pathological complete response to neoadjuvant treatment. The difference in expression levels between patients who achieved a pathological complete response and those who did not was greatest for EHBP1. Gene network analysis showed that the 3 genes can be connected by the gene UBC. ConclusionThis study identifies a 3-gene signature expressed in pre-treatment tumor biopsies that correlates with a pathological complete response to neoadjuvant chemoradiation in patients with clinical stage II and III rectal cancer. These 3 genes can be connected by the gene UBC, suggesting that ubiquination is a molecular mechanism involved in determining response to treatment. Validating this genet

  16. Visible Wavelength Reflectance Spectra and Taxonomies of Near-Earth Objects from Apache Point Observatory

    Science.gov (United States)

    Hammergren, Mark; Brucker, Melissa J.; Nault, Kristie A.; Gyuk, Geza; Solontoi, Michael R.

    2015-11-01

    Near-Earth Objects (NEOs) are interesting to scientists and the general public for diverse reasons: their impacts pose a threat to life and property; they present important albeit biased records of the formation and evolution of the Solar System; and their materials may provide in situ resources for future space exploration and habitation.In January 2015 we began a program of NEO astrometric follow-up and physical characterization using a 17% share of time on the Astrophysical Research Consortium (ARC) 3.5-meter telescope at Apache Point Observatory (APO). Our 500 hours of annual observing time are split into frequent, short astrometric runs (see poster by K. A. Nault et. al), and half-night runs devoted to physical characterization (see poster by M. J. Brucker et. al for preliminary rotational lightcurve results). NEO surface compositions are investigated with 0.36-1.0 μm reflectance spectroscopy using the Dual Imaging Spectrograph (DIS) instrument. As of August 25, 2015, including testing runs during fourth quarter 2014, we have obtained reflectance spectra of 68 unique NEOs, ranging in diameter from approximately 5m to 8km.In addition to investigating the compositions of individual NEOs to inform impact hazard and space resource evaluations, we may examine the distribution of taxonomic types and potential trends with other physical and orbital properties. For example, the Yarkovsky effect, which is dependent on asteroid shape, mass, rotation, and thermal characteristics, is believed to dominate other dynamical effects in driving the delivery of small NEOs from the main asteroid belt. Studies of the taxonomic distribution of a large sample of NEOs of a wide range of sizes will test this hypothesis.We present a preliminary analysis of the reflectance spectra obtained in our survey to date, including taxonomic classifications and potential trends with size.Acknowledgements: Based on observations obtained with the Apache Point Observatory 3.5-meter telescope, which

  17. Update on Astrometric Follow-Up at Apache Point Observatory by Adler Planetarium

    Science.gov (United States)

    Nault, Kristie A.; Brucker, Melissa; Hammergren, Mark

    2016-10-01

    We began our NEO astrometric follow-up and characterization program in 2014 Q4 using about 500 hours of observing time per year with the Astrophysical Research Consortium (ARC) 3.5m telescope at Apache Point Observatory (APO). Our observing is split into 2 hour blocks approximately every other night for astrometry (this poster) and several half-nights per month for spectroscopy (see poster by M. Hammergren et al.) and light curve studies.For astrometry, we use the ARC Telescope Imaging Camera (ARCTIC) with an SDSS r filter, in 2 hour observing blocks centered around midnight. ARCTIC has a magnitude limit of V~23 in 60s, and we target 20 NEOs per session. ARCTIC has a FOV 1.57 times larger and a readout time half as long as the previous imager, SPIcam, which we used from 2014 Q4 through 2015 Q3. Targets are selected primarily from the Minor Planet Center's (MPC) NEO Confirmation Page (NEOCP), and NEA Observation Planning Aid; we also refer to JPL's What's Observable page, the Spaceguard Priority List and Faint NEOs List, and requests from other observers. To quickly adapt to changing weather and seeing conditions, we create faint, midrange, and bright target lists. Detected NEOs are measured with Astrometrica and internal software, and the astrometry is reported to the MPC.As of June 19, 2016, we have targeted 2264 NEOs, 1955 with provisional designations, 1582 of which were detected. We began observing NEOCP asteroids on January 30, 2016, and have targeted 309, 207 of which were detected. In addition, we serendipitously observed 281 moving objects, 201 of which were identified as previously known objects.This work is based on observations obtained with the Apache Point Observatory 3.5m telescope, which is owned and operated by the Astrophysical Research Consortium. We gratefully acknowledge support from NASA NEOO award NNX14AL17G and thank the University of Chicago Department of Astronomy and Astrophysics for observing time in 2014.

  18. Building a Snow Data System on the Apache OODT Open Technology Stack

    Science.gov (United States)

    Goodale, C. E.; Painter, T. H.; Mattmann, C. A.; Hart, A. F.; Ramirez, P.; Zimdars, P.; Bryant, A. C.; Snow Data System Team

    2011-12-01

    Snow cover and its melt dominate regional climate and hydrology in many of the world's mountainous regions. One-sixth of Earth's population depends on snow- or glacier-melt for water resources. Operationally, seasonal forecasts of snowmelt-generated streamflow are leveraged through empirical relations based on past snowmelt periods. These historical data show that climate is changing, but the changes reduce the reliability of the empirical relations. Therefore optimal future management of snowmelt derived water resources will require explicit physical models driven by remotely sensed snow property data. Toward this goal, the Snow Optics Laboratory at the Jet Propulsion Laboratory has initiated a near real-time processing pipeline to generate and publish post-processed snow data products within a few hours of satellite acquisition. To solve this challenge, a Scientific Data Management and Processing System was required and the JPL Team leveraged an open-source project called Object Oriented Data Technology (OODT). OODT was developed within NASA's Jet Propulsion Laboratory across the last 10 years. OODT has supported various scientific data management and processing projects, providing solutions in the Earth, Planetary, and Medical science fields. It became apparent that the project needed to be opened to a larger audience to foster and promote growth and adoption. OODT was open-sourced at the Apache Software Foundation in November 2010 and has a growing community of users and committers that are constantly improving the software. Leveraging OODT, the JPL Snow Data System (SnowDS) Team was able to install and configure a core Data Management System (DMS) that would download MODIS raw data files and archive the products in a local repository for post processing. The team has since built an online data portal, and an algorithm-processing pipeline using the Apache OODT software as the foundation. We will present the working SnowDS system with its core remote sensing

  19. 基于Access和VBA的APACHE-Ⅱ评分数据库的建立及其在急诊科中的应用%Constuction and validation of APACHE-Ⅱscore based on Access and visual basic application in Emergency

    Institute of Scientific and Technical Information of China (English)

    伍卓文; 江慧琳; 莫均荣

    2013-01-01

    Objectives:To develop an APACHE-Ⅱscore database, base on Access and Visual Basic Application(VBA), for critical critical y il patients presenting to emergency department ,and to explore its application value in emergency medicine.Methods:APACHE-Ⅱ score database was development by Access 2007 and VBA according to the content of APACHE-Ⅱscore.Results:APACHE-Ⅱscore database had the advantage of convenient and complete data processing, variety inquiry, automatical y calculation, stratification and statistical analysis.Conclusions:An APACHE-Ⅱscore database, base on Access and Visual Basic Application(VBA), can be easily to use for record the data of critical y il patients in the emergency. It is not only simple and convenient, but also contribute to clinical management ,teaching and research work.%目的:以Access数据库和Visual Basic应用程序(VBA)为基础,建立急诊危重病患者APACHE -Ⅱ评分数据库,并探讨其在急诊医学中的应用。方法:根据APACHE-Ⅱ评分内容通过Access2007软件构件APACHE-Ⅱ评分数据库。结果:通过数据库全面和准确记录病患资料,同时可有多条件的查询功能、自动的APACHE-Ⅱ和危险分层以及科研数据分析的功能。结论:以Access和VBA为基础建立一个简易、便捷的APACHE-Ⅱ数据库可方便急诊危重病患者的信息化管理,不仅有利于临床诊疗,而且利于教学和科研工作。

  20. The APACHE survey hardware and software design: Tools for an automatic search of small-size transiting exoplanets

    Directory of Open Access Journals (Sweden)

    Lattanzi M.G.

    2013-04-01

    Full Text Available Small-size ground-based telescopes can effectively be used to look for transiting rocky planets around nearby low-mass M stars using the photometric transit method, as recently demonstrated for example by the MEarth project. Since 2008 at the Astronomical Observatory of the Autonomous Region of Aosta Valley (OAVdA, we have been preparing for the long-term photometric survey APACHE, aimed at finding transiting small-size planets around thousands of nearby early and mid-M dwarfs. APACHE (A PAthway toward the Characterization of Habitable Earths is designed to use an array of five dedicated and identical 40-cm Ritchey-Chretien telescopes and its observations started at the beginning of summer 2012. The main characteristics of the survey final set up and the preliminary results from the first weeks of observations will be discussed.

  1. Archery by the Apaches – implications of using the bow and arrow in hunter-gatherer communities

    Directory of Open Access Journals (Sweden)

    Žiga Šmit

    2016-12-01

    Full Text Available This review focuses on the technical and social details of production, training, and use of archery equipment by a Native American tribe, the Apaches. The study aims to understand the use of the bow in the Mesolithic and Early and Middle Neolithic societies of the Old World. The paper further describes arrow ballistics. An arrow and bow with similar dimensions and materials to those used by the Apaches was reconstructed and used in ballistic experiments. Shooting and the subsequent model calculation showed that the effective range of arrows made of reed and projected by a bow of medium strength (16–18kg was not more than approx. 20m. Due to the initial flat part of the ballistic trajectory, such arrows were quite efficient in close-range contests. Within the model calculation, a regression procedure was introduced to determine the arrow air-drag parameters from an ensemble of shots.

  2. Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study.

    Science.gov (United States)

    Dienstmann, R; Mason, M J; Sinicrope, F A; Phipps, A I; Tejpar, S; Nesbakken, A; Danielsen, S A; Sveen, A; Buchanan, D D; Clendenning, M; Rosty, C; Bot, B; Alberts, S R; Milburn Jessup, J; Lothe, R A; Delorenzi, M; Newcomb, P A; Sargent, D; Guinney, J

    2017-05-01

    TNM staging alone does not accurately predict outcome in colon cancer (CC) patients who may be eligible for adjuvant chemotherapy. It is unknown to what extent the molecular markers microsatellite instability (MSI) and mutations in BRAF or KRAS improve prognostic estimation in multivariable models that include detailed clinicopathological annotation. After imputation of missing at random data, a subset of patients accrued in phase 3 trials with adjuvant chemotherapy (n = 3016)-N0147 (NCT00079274) and PETACC3 (NCT00026273)-was aggregated to construct multivariable Cox models for 5-year overall survival that were subsequently validated internally in the remaining clinical trial samples (n = 1499), and also externally in different population cohorts of chemotherapy-treated (n = 949) or -untreated (n = 1080) CC patients, and an additional series without treatment annotation (n = 782). TNM staging, MSI and BRAFV600E mutation status remained independent prognostic factors in multivariable models across clinical trials cohorts and observational studies. Concordance indices increased from 0.61-0.68 in the TNM alone model to 0.63-0.71 in models with added molecular markers, 0.65-0.73 with clinicopathological features and 0.66-0.74 with all covariates. In validation cohorts with complete annotation, the integrated time-dependent AUC rose from 0.64 for the TNM alone model to 0.67 for models that included clinicopathological features, with or without molecular markers. In patient cohorts that received adjuvant chemotherapy, the relative proportion of variance explained (R2) by TNM, clinicopathological features and molecular markers was on an average 65%, 25% and 10%, respectively. Incorporation of MSI, BRAFV600E and KRAS mutation status to overall survival models with TNM staging improves the ability to precisely prognosticate in stage II and III CC patients, but only modestly increases prediction accuracy in multivariable models that include

  3. 基于ADache的分布协作Web服务器%Distributed Cooperative Web Server Based on Apache

    Institute of Scientific and Technical Information of China (English)

    刘华东; 张芸

    2002-01-01

    在详细说明Apache Web服务器工作原理的基础上,介绍了DC-Apache系统的功能结构,讨论了DC-Apache模块设计中的关键问题,着重对原系统模型及其实现方法作了论述.最后对实现的DC-Apache系统进行了测试和评估.

  4. Spatial correlations of Diceroprocta apache and its host plants: Evidence for a negative impact from Tamarix invasion

    Science.gov (United States)

    Ellingson, A.R.; Andersen, D.C.

    2002-01-01

    1. The hypothesis that the habitat-scale spatial distribution of the, Apache cicada Diceroprocta apache Davis is unaffected by the presence of the invasive exotic saltcedar Tamarix ramosissima was tested using data from 205 1-m2 quadrats placed within the flood-plain of the Bill Williams River, Arizona, U.S.A. Spatial dependencies within and between cicada density and habitat variables were estimated using Moran's I and its bivariate analogue to discern patterns and associations at spatial scales from 1 to 30 m. 2. Apache cicadas were spatially aggregated in high-density clusters averaging 3m in diameter. A positive association between cicada density, estimated by exuvial density, and the per cent canopy cover of a native tree, Goodding's willow Salix gooddingii, was detected in a non-spatial correlation analysis. No non-spatial association between cicada density and saltcedar canopy cover was detected. 3. Tests for spatial cross-correlation using the bivariate IYZ indicated the presence of a broad-scale negative association between cicada density and saltcedar canopy cover. This result suggests that large continuous stands of saltcedar are associated with reduced cicada density. In contrast, positive associations detected at spatial scales larger than individual quadrats suggested a spill-over of high cicada density from areas featuring Goodding's willow canopy into surrounding saltcedar monoculture. 4. Taken together and considered in light of the Apache cicada's polyphagous habits, the observed spatial patterns suggest that broad-scale factors such as canopy heterogeneity affect cicada habitat use more than host plant selection. This has implications for management of lower Colorado River riparian woodlands to promote cicada presence and density through maintenance or creation of stands of native trees as well as manipulation of the characteristically dense and homogeneous saltcedar canopies.

  5. A Comparison of Predictive Thermo and Water Solvation Property Prediction Tools and Experimental Data for Selected Traditional Chemical Warfare Agents and Simulants II: COSMO RS and COSMOTherm

    Science.gov (United States)

    2017-04-01

    A COMPARISON OF PREDICTIVE THERMO AND WATER SOLVATION PROPERTY PREDICTION TOOLS AND EXPERIMENTAL DATA FOR...4. TITLE AND SUBTITLE A Comparison of Predictive Thermo and Water Solvation Property Prediction Tools and Experimental Data for Selected...ambient temperature. We then directed these descriptions of each molecule to COSMOTherm to calculate boiling point, vapor pressure, water solubility

  6. Efficient Streaming Mass Spatio-Temporal Vehicle Data Access in Urban Sensor Networks Based on Apache Storm

    Directory of Open Access Journals (Sweden)

    Lianjie Zhou

    2017-04-01

    Full Text Available The efficient data access of streaming vehicle data is the foundation of analyzing, using and mining vehicle data in smart cities, which is an approach to understand traffic environments. However, the number of vehicles in urban cities has grown rapidly, reaching hundreds of thousands in number. Accessing the mass streaming data of vehicles is hard and takes a long time due to limited computation capability and backward modes. We propose an efficient streaming spatio-temporal data access based on Apache Storm (ESDAS to achieve real-time streaming data access and data cleaning. As a popular streaming data processing tool, Apache Storm can be applied to streaming mass data access and real time data cleaning. By designing the Spout/bolt workflow of topology in ESDAS and by developing the speeding bolt and other bolts, Apache Storm can achieve the prospective aim. In our experiments, Taiyuan BeiDou bus location data is selected as the mass spatio-temporal data source. In the experiments, the data access results with different bolts are shown in map form, and the filtered buses’ aggregation forms are different. In terms of performance evaluation, the consumption time in ESDAS for ten thousand records per second for a speeding bolt is approximately 300 milliseconds, and that for MongoDB is approximately 1300 milliseconds. The efficiency of ESDAS is approximately three times higher than that of MongoDB.

  7. Efficient Streaming Mass Spatio-Temporal Vehicle Data Access in Urban Sensor Networks Based on Apache Storm.

    Science.gov (United States)

    Zhou, Lianjie; Chen, Nengcheng; Chen, Zeqiang

    2017-04-10

    The efficient data access of streaming vehicle data is the foundation of analyzing, using and mining vehicle data in smart cities, which is an approach to understand traffic environments. However, the number of vehicles in urban cities has grown rapidly, reaching hundreds of thousands in number. Accessing the mass streaming data of vehicles is hard and takes a long time due to limited computation capability and backward modes. We propose an efficient streaming spatio-temporal data access based on Apache Storm (ESDAS) to achieve real-time streaming data access and data cleaning. As a popular streaming data processing tool, Apache Storm can be applied to streaming mass data access and real time data cleaning. By designing the Spout/bolt workflow of topology in ESDAS and by developing the speeding bolt and other bolts, Apache Storm can achieve the prospective aim. In our experiments, Taiyuan BeiDou bus location data is selected as the mass spatio-temporal data source. In the experiments, the data access results with different bolts are shown in map form, and the filtered buses' aggregation forms are different. In terms of performance evaluation, the consumption time in ESDAS for ten thousand records per second for a speeding bolt is approximately 300 milliseconds, and that for MongoDB is approximately 1300 milliseconds. The efficiency of ESDAS is approximately three times higher than that of MongoDB.

  8. Visible Wavelength Reflectance Spectra of Near-Earth Objects from Apache Point Observatory: Science Highlights

    Science.gov (United States)

    Hammergren, Mark; Brucker, Melissa; Nault, Kristie A.; Gyuk, Geza

    2016-10-01

    In January 2015 we began a program of near-Earth object (NEO) astrometric follow-up and physical characterization using a 17% share of time on the Astrophysical Research Consortium (ARC) 3.5-meter telescope at Apache Point Observatory (APO). Our roughly 500 hours of annual observing time are split into 2 hour runs usually in the middle of every other night (see poster by K. Nault et al.), and frequent half-night runs devoted to physical characterization (this poster). NEO surface compositions are investigated with 0.36-1.0 μm reflectance spectroscopy using the Dual Imaging Spectrograph instrument. As of June 22, 2016 we have obtained reflectance spectra of 129 unique NEOs, ranging in diameter from approximately 5 m to 6 km.Highlights of this work presented here include 106 spectra of (357439) 2004 BL86 spanning 3 hours 4.5 minutes, more than a full rotation, and spectra of 18 objects with diameters comparable to historical Earth impactors (e.g., Tunguska, Chelyabinsk and smaller bolides).This work is based on observations obtained with the APO 3.5-meter telescope, which is owned and operated by ARC. We gratefully acknowledge support from NASA NEOO award NNX14AL17G, and thank the University of Chicago Department of Astronomy and Astrophysics for observing time in 2014.

  9. The Apache Point Observatory Galactic Evolution Experiment (APOGEE) and its successor, APOGEE-2

    Science.gov (United States)

    Majewski, S. R.; APOGEE Team; APOGEE-2 Team

    2016-09-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE) of Sloan Digital Sky Survey III (SDSS-III) has produced a large catalog of high resolution ({R = 22 500}), high quality (S/N > 100), infrared (H-band) spectra for stars throughout all stellar populations of the Milky Way, including in regions veiled by significant dust opacity. APOGEE's half million spectra collected on > 163 000 unique stars, with time series information via repeat visits to each star, are being applied to numerous problems in stellar populations, Galactic astronomy, and stellar astrophysics. From among the early results of the APOGEE project - which span from measurements of Galactic dynamics, to multi-element chemical maps of the disk and bulge, new views of the interstellar medium, explorations of stellar companions, the chemistry of star clusters, and the discovery of rare stellar species - I highlight a few results that demonstrate APOGEE's unique ability to sample and characterize the Galactic disk and bulge. Plans are now under way for an even more ambitious successor to APOGEE: the six-year, dual-hemisphere APOGEE-2 project. Both phases of APOGEE feature a strong focus on targets having asteroseismological measurements from either Kepler or {CoRoT}, from which it is possible to derive relatively precise stellar ages. The combined APOGEE and APOGEE-2 databases of stellar chemistry, dynamics and ages constitute an unusually comprehensive, systematic and homogeneous resource for constraining models of Galactic evolution.

  10. Cultural Foundations for Ecological Restoration on the White Mountain Apache Reservation

    Directory of Open Access Journals (Sweden)

    Jonathan Long

    2003-12-01

    Full Text Available Myths, metaphors, and social norms that facilitate collective action and understanding of restoration dynamics serve as foundations for ecological restoration. The experience of the White Mountain Apache Tribe demonstrates how such cultural foundations can permeate and motivate ecological restoration efforts. Through interviews with tribal cultural advisors and restoration practitioners, we examined how various traditions inform their understanding of restoration processes. Creation stories reveal the time-honored importance and functions of water bodies within the landscape, while place names yield insights into their historical and present conditions. Traditional healing principles and agricultural traditions help guide modern restoration techniques. A metaphor of stability illustrates how restoration practitioners see links among ecological, social, and personal dimensions of health. These views inspire reciprocal relationships focused on caretaking of sites, learning from elders, and passing knowledge on to youths. Woven together, these cultural traditions uphold a system of adaptive management that has withstood the imposition of non-indigenous management schemes in the 20th century, and now provides hope for restoring health and productivity of ecosystems through individual and collective efforts. Although these traditions are adapted to the particular ecosystems of the Tribe, they demonstrate the value of understanding and promoting the diverse cultural foundations of restoration.

  11. THE DATA REDUCTION PIPELINE FOR THE APACHE POINT OBSERVATORY GALACTIC EVOLUTION EXPERIMENT

    Energy Technology Data Exchange (ETDEWEB)

    Nidever, David L. [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States); Holtzman, Jon A. [New Mexico State University, Las Cruces, NM 88003 (United States); Prieto, Carlos Allende; Mészáros, Szabolcs [Instituto de Astrofísica de Canarias, Via Láctea s/n, E-38205 La Laguna, Tenerife (Spain); Beland, Stephane [Laboratory for Atmospheric and Space Sciences, University of Colorado at Boulder, Boulder, CO (United States); Bender, Chad; Desphande, Rohit [Department of Astronomy and Astrophysics, The Pennsylvania State University, University Park, PA 16802 (United States); Bizyaev, Dmitry [Apache Point Observatory and New Mexico State University, P.O. Box 59, sunspot, NM 88349-0059 (United States); Burton, Adam; García Pérez, Ana E.; Hearty, Fred R.; Majewski, Steven R.; Skrutskie, Michael F.; Sobeck, Jennifer S.; Wilson, John C. [Department of Astronomy, University of Virginia, Charlottesville, VA 22904-4325 (United States); Fleming, Scott W. [Computer Sciences Corporation, 3700 San Martin Dr, Baltimore, MD 21218 (United States); Muna, Demitri [Department of Astronomy and the Center for Cosmology and Astro-Particle Physics, The Ohio State University, Columbus, OH 43210 (United States); Nguyen, Duy [Department of Astronomy and Astrophysics, University of Toronto, Toronto, Ontario, M5S 3H4 (Canada); Schiavon, Ricardo P. [Gemini Observatory, 670 N. A’Ohoku Place, Hilo, HI 96720 (United States); Shetrone, Matthew, E-mail: dnidever@umich.edu [University of Texas at Austin, McDonald Observatory, Fort Davis, TX 79734 (United States)

    2015-12-15

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE), part of the Sloan Digital Sky Survey III, explores the stellar populations of the Milky Way using the Sloan 2.5-m telescope linked to a high resolution (R ∼ 22,500), near-infrared (1.51–1.70 μm) spectrograph with 300 optical fibers. For over 150,000 predominantly red giant branch stars that APOGEE targeted across the Galactic bulge, disks and halo, the collected high signal-to-noise ratio (>100 per half-resolution element) spectra provide accurate (∼0.1 km s{sup −1}) RVs, stellar atmospheric parameters, and precise (≲0.1 dex) chemical abundances for about 15 chemical species. Here we describe the basic APOGEE data reduction software that reduces multiple 3D raw data cubes into calibrated, well-sampled, combined 1D spectra, as implemented for the SDSS-III/APOGEE data releases (DR10, DR11 and DR12). The processing of the near-IR spectral data of APOGEE presents some challenges for reduction, including automated sky subtraction and telluric correction over a 3°-diameter field and the combination of spectrally dithered spectra. We also discuss areas for future improvement.

  12. Integrating the Apache Big Data Stack with HPC for Big Data

    Science.gov (United States)

    Fox, G. C.; Qiu, J.; Jha, S.

    2014-12-01

    There is perhaps a broad consensus as to important issues in practical parallel computing as applied to large scale simulations; this is reflected in supercomputer architectures, algorithms, libraries, languages, compilers and best practice for application development. However, the same is not so true for data intensive computing, even though commercially clouds devote much more resources to data analytics than supercomputers devote to simulations. We look at a sample of over 50 big data applications to identify characteristics of data intensive applications and to deduce needed runtime and architectures. We suggest a big data version of the famous Berkeley dwarfs and NAS parallel benchmarks and use these to identify a few key classes of hardware/software architectures. Our analysis builds on combining HPC and ABDS the Apache big data software stack that is well used in modern cloud computing. Initial results on clouds and HPC systems are encouraging. We propose the development of SPIDAL - Scalable Parallel Interoperable Data Analytics Library -- built on system aand data abstractions suggested by the HPC-ABDS architecture. We discuss how it can be used in several application areas including Polar Science.

  13. High performance Spark best practices for scaling and optimizing Apache Spark

    CERN Document Server

    Karau, Holden

    2017-01-01

    Apache Spark is amazing when everything clicks. But if you haven’t seen the performance improvements you expected, or still don’t feel confident enough to use Spark in production, this practical book is for you. Authors Holden Karau and Rachel Warren demonstrate performance optimizations to help your Spark queries run faster and handle larger data sizes, while using fewer resources. Ideal for software engineers, data engineers, developers, and system administrators working with large-scale data applications, this book describes techniques that can reduce data infrastructure costs and developer hours. Not only will you gain a more comprehensive understanding of Spark, you’ll also learn how to make it sing. With this book, you’ll explore: How Spark SQL’s new interfaces improve performance over SQL’s RDD data structure The choice between data joins in Core Spark and Spark SQL Techniques for getting the most out of standard RDD transformations How to work around performance issues i...

  14. TARGET SELECTION FOR THE APACHE POINT OBSERVATORY GALACTIC EVOLUTION EXPERIMENT (APOGEE)

    Energy Technology Data Exchange (ETDEWEB)

    Zasowski, G.; Johnson, Jennifer A.; Andrews, B.; Epstein, C. [Department of Astronomy, Ohio State University, Columbus, OH 43210 (United States); Frinchaboy, P. M.; Jackson, K. [Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX 76129 (United States); Majewski, S. R.; Chojnowski, S. D.; Skrutskie, M. F.; Beaton, R. L. [Department of Astronomy, University of Virginia, Charlottesville, VA 22904 (United States); Nidever, D. L. [Department of Astronomy, University of Michigan, Ann Arbor, MI 48109 (United States); Pinto, H. J. Rocha; Girardi, L. [Laboratorio Interinstitucional de e-Astronomia-LIneA, Rio de Janeiro, RJ 20921-400 (Brazil); Cudworth, K. M. [Yerkes Observatory, University of Chicago, Williams Bay, WI 53191 (United States); Munn, J. [US Naval Observatory, Flagstaff Station, Flagstaff, AZ 86001 (United States); Blake, C. H. [Department of Astrophysical Sciences, Princeton University, Princeton, NJ 08544 (United States); Covey, K. [Lowell Observatory, Flagstaff, AZ 86001 (United States); Deshpande, R.; Fleming, S. W. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Fabbian, D., E-mail: gail.zasowski@gmail.com [Instituto de Astrofisica de Canarias, Calle Via Lactea s/n, E-38205 La Laguna, Tenerife (Spain); and others

    2013-10-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE) is a high-resolution infrared spectroscopic survey spanning all Galactic environments (i.e., bulge, disk, and halo), with the principal goal of constraining dynamical and chemical evolution models of the Milky Way. APOGEE takes advantage of the reduced effects of extinction at infrared wavelengths to observe the inner Galaxy and bulge at an unprecedented level of detail. The survey's broad spatial and wavelength coverage enables users of APOGEE data to address numerous Galactic structure and stellar populations issues. In this paper we describe the APOGEE targeting scheme and document its various target classes to provide the necessary background and reference information to analyze samples of APOGEE data with awareness of the imposed selection criteria and resulting sample properties. APOGEE's primary sample consists of {approx}10{sup 5} red giant stars, selected to minimize observational biases in age and metallicity. We present the methodology and considerations that drive the selection of this sample and evaluate the accuracy, efficiency, and caveats of the selection and sampling algorithms. We also describe additional target classes that contribute to the APOGEE sample, including numerous ancillary science programs, and we outline the targeting data that will be included in the public data releases.

  15. FEASIBILITY STUDY FOR A PETROLEUM REFINERY FOR THE JICARILLA APACHE TRIBE

    Energy Technology Data Exchange (ETDEWEB)

    John D. Jones

    2004-10-01

    A feasibility study for a proposed petroleum refinery for the Jicarilla Apache Indian Reservation was performed. The available crude oil production was identified and characterized. There is 6,000 barrels per day of crude oil production available for processing in the proposed refinery. The proposed refinery will utilize a lower temperature, smaller crude fractionation unit. It will have a Naphtha Hydrodesulfurizer and Reformer to produce high octane gasoline. The surplus hydrogen from the reformer will be used in a specialized hydrocracker to convert the heavier crude oil fractions to ultra low sulfur gasoline and diesel fuel products. The proposed refinery will produce gasoline, jet fuel, diesel fuel, and a minimal amount of lube oil. The refinery will require about $86,700,000 to construct. It will have net annual pre-tax profit of about $17,000,000. The estimated return on investment is 20%. The feasibility is positive subject to confirmation of long term crude supply. The study also identified procedures for evaluating processing options as a means for American Indian Tribes and Native American Corporations to maximize the value of their crude oil production.

  16. Instalación y configuración de Apache, un servidor Web gratis

    Directory of Open Access Journals (Sweden)

    José Márquez Díaz

    2002-01-01

    Full Text Available El servidor web Apache se ha convertido en el servidor web más utilizado en el mundo debido a sus altas prestaciones y desempeño, además de ser gratuito, lo cual contribuye a su rápida expansión y posicionamiento. La configuración de este servidor web para aquellas personas que posean un conocimiento medio del sistema operativo Linux no debe ser un problema, pero resulta en ocasiones complicado e intimidante enfrentarse a los archivos de configuración del servidor sin una guía o con la base de la información fragmentada y de lenguaje oscuro que se puede obtener en la web. El propósito de este artículo es ayudar a aquellas personas que deseen configurar un servidor HTTP a cumplir su objetivo de una manera sencilla y rápida para lograr una excelente configuración y puesta en marcha de alto rendimiento

  17. 应用APACHE Ⅱ评分和SIRS评分对脓毒症患者预后评估的研究

    Institute of Scientific and Technical Information of China (English)

    李新颖

    2011-01-01

    目的 探讨全身炎症反应综合征(SIRS) 评分与急性生理和慢性健康状况(APACHE) Ⅱ评分对脓毒症患者预后评估的意义.方法 分析我院外科监护室(ICU)收治的112 例脓毒症患者临床资料,进行SIRS评分与APACHE Ⅱ评分,分析SIRS和APACHE Ⅱ评分与病死率的关系.结果 随着SIRS与APACHE Ⅱ分值的增加,病死率也增加,SIRS评分≥2或APACHE Ⅱ评分≥25时病人病死率明显增加(P<0.05).结论 SIRS评分与APACHE Ⅱ评分一样能够预测脓毒症患者的预后,且简单实用.

  18. Apache Server Security Countermeasures Base on Linux System%基于Linux系统的Apache服务器安全对策

    Institute of Scientific and Technical Information of China (English)

    周永强

    2013-01-01

    Apache web具有良好的跨平台性和极强的可扩展性,功能强大。虽然Apache也存在诸如拒绝服务攻击、缓冲区溢出攻击、非法获得root权限等安全缺陷。讨论了从Linux系统的安全入手并加强Apache服务器的配置,对安全漏洞采取积极的防范措施,从而提高Apache web安全性的方法。%Apache web has a good cross platform and strong expansibility, and it’s powerful. Although the Apache also exist some, such as denial of service attacks, buffer overflow attacks, illegal gain root permissions and some. As long as taking active preventive measures of security flaws, starting from a Linux system security,the Apache server configuration is enhanced,thereby enhancing the Apache web security.

  19. Incremental validity of WISC-IV(UK) factor index scores with a referred Irish sample: predicting performance on the WIAT-II(UK.).

    Science.gov (United States)

    Canivez, Gary L; Watkins, Marley W; James, Trevor; Good, Rebecca; James, Kate

    2014-12-01

    Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. This study examined the incremental validity of Wechsler Intelligence Scale for Children - Fourth UK Edition (WISC-IV(UK) ; Wechsler, 2004a, Wechsler Intelligence Scale for Children - Fourth UK Edition, Harcourt Assessment, London, UK) and factor index scores in predicting academic achievement on the Wechsler Individual Achievement Test - Second UK Edition (WIAT-II(UK) ; Wechsler, 2005a, Wechsler Individual Achievement Test-Second UK Edition, Pearson, London, UK), beyond that predicted by the WISC-IV(UK) FSIQ. The sample included 1,014 Irish children (ages 6-0 to 16-9) who were referred for evaluation of learning difficulties. Hierarchical multiple regression analyses were used with the WISC-IV(UK) FSIQ (Block 1) and factor index scores (Block 2) as predictors and WIAT-II(UK) subtest and composite scores as dependent variables. The WISC-IV(UK) FSIQ accounted for statistically significant and generally large portions of WIAT-II(UK) subtest and composite score variance. WISC-IV(UK) factor index scores combined to provide statistically significant increments in prediction of most WIAT-II(UK) subtest and composite scores over and above the FSIQ; however, the effect sizes were mostly small as previously observed (i.e., Canivez, 2013a, Psychol. Assess., 25, 484; Glutting et al., 2006, J. Spec. Educ., 40, 103; Nelson et al., 2013, Psychol. Assess., 25, 618). Individually, the WISC-IV(UK) factor index scores provided small unique contributions to predicting WIAT-II(UK) scores. This, in combination with studies of apportioned variance from bifactor confirmatory factor analysis (Watkins et al., 2013, Int. J. Sch. Educ. Psychol., 1, 102), indicated that the WISC-IV(UK) FSIQ should retain the greatest weight in WISC-IV(UK) interpretation. © 2014 The British Psychological Society.

  20. Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programme database.

    Science.gov (United States)

    Kolhe, Nitin V; Stevens, Paul E; Crowe, Alex V; Lipkin, Graham W; Harrison, David A

    2008-01-01

    This study pools data from the UK Intensive Care National Audit and Research Center (ICNARC) Case Mix Programme (CMP) to evaluate the case mix, outcome and activity for 17,326 patients with severe acute kidney injury (AKI) occurring during the first 24 hours of admission to intensive care units (ICU). Severe AKI admissions (defined as serum creatinine >/=300 mumol/l and/or urea >/=40 mmol/l during the first 24 hours) were extracted from the ICNARC CMP database of 276,326 admissions to UK ICUs from 1995 to 2004. Subgroups of oliguric and nonoliguric AKI were identified by daily urine output. Data on surgical status, survival and length of stay were also collected. Severity of illness scores and mortality prediction models were compared (UK Acute Physiology and Chronic Health Evaluation [APACHE] II, Stuivenberg Hospital Acute Renal Failure [SHARF] T0, SHARF II0 and the Mehta model). Severe AKI occurred in 17,326 out of 276,731 admissions (6.3%). The source of admission was nonsurgical in 83.7%. Sepsis was present in 47.3% and AKI was nonoliguric in 63.9% of cases. Admission to ICU with severe AKI accounted for 9.3% of all ICU bed-days. Oliguric AKI was associated with longer length of stay for survivors and shorter length of stay for nonsurvivors compared with nonoliguric AKI. Oliguric AKI was associated with significantly greater ICU and hospital mortality (55.8% and 77.3%, respectively) compared with nonoliguric AKI (33.4% and 49.3%, respectively). Surgery during the 1 week before admission or during the first week in the CMP unit was associated with decreased odds of mortality. UK APACHE II and the Mehta scores under-predicted the number of deaths, whereas SHARF T0 and SHARF II0 over-predicted the number of deaths. Severe AKI accounts for over 9% of all bed-days in adult, general ICUs, representing a considerable drain on resources. Although nonoliguric AKI continues to confer a survival benefit, overall survival from AKI in the ICU and survival to leave hospital

  1. Improvement of a clinical prediction rule for clinical trials on prophylaxis for invasive candidiasis in the intensive care unit.

    Science.gov (United States)

    Ostrosky-Zeichner, Luis; Pappas, Peter G; Shoham, Shmuel; Reboli, Annette; Barron, Michelle A; Sims, Charles; Wood, Craig; Sobel, Jack D

    2011-01-01

    We created a clinical prediction rule to identify patients at risk of invasive candidiasis (IC) in the intensive care unit (ICU) (Eur J Clin Microbiol Infect Dis 2007; 26:271). The rule applies to <10% of patients in ICUs. We sought to create a more inclusive rule for clinical trials. Retrospective review of patients admitted to ICU ≥ 4 days, collecting risk factors and outcomes. Variations of the rule based on introduction of mechanical ventilation and risk factors were assessed. We reviewed 597 patients with a mean APACHE II score of 14.4, mean ICU stay of 12.5 days and mean ventilation time of 10.7 days. A variation of the rule requiring mechanical ventilation AND central venous catheter AND broad spectrum antibiotics on days 1-3 AND an additional risk factor applied to 18% of patients, maintaining the incidence of IC at 10%. Modification of our original rule resulted in a more inclusive rule for studies.

  2. A Study of Impairing Injuries in Real World Crashes Using the Injury Impairment Scale (IIS) and the Predicted Functional Capacity Index (PFCI-AIS)

    Science.gov (United States)

    Barnes, Jo; Morris, Andrew

    2009-01-01

    The ability to predict impairment outcomes in large databases using a simplified technique allows researchers to focus attention on preventing costly impairing injuries. The dilemma that exists for researchers is to determine which method is the most reliable and valid. This study examines available methods to predict impairment and explores the differences between the IIS and pFCI applied to real world crash injury data. Occupant injury data from the UK Co-operative Crash Injury Study (CCIS) database have been coded using AIS 1990 and AIS 2005. The data have subsequently been recoded using the associated impairment scales namely the Injury Impairment Scale (IIS) and the predicted Functional Capacity Index (pFCI) to determine the predicted impairment levels of injuries at one year post crash. Comparisons between the levels of impairment were made and any differences further explored. Injury data for the period February 2006 to September 2008 from the CCIS database were used in the analysis which involved a dataset of 2,437 occcupants who sustained over 8000 injuries. This study found some differences between the impairment scales for injuries coded to the AIS 1990 and AIS 2005 coding dictionaries. The pFCI predicts 31.5% of injuries to be impairing in AIS 2005, less than the IIS (38.5%) using AIS 1990. Using CCIS data the pFCI predicted that only 6% of the occupants with a coded injury would have an impairing injury compared to 24% of occupants using the IIS. The main body regions identified as having the major differences between the two impairment scales for car occupants were the head and spine. Follow up data were then used for a small number of cases (n=31, lower extremity and whiplash injuries) to examine any differences in predicted impairment versus perceived impairment. These data were selected from a previous study conducted between 2003 and 2006 and identified the discrepancy between predicted impairment and actual perceived impairment as defined by the

  3. Predictive model for Pb(II) adsorption on soil minerals (oxides and low-crystalline aluminum silicate) consistent with spectroscopic evidence

    Science.gov (United States)

    Usiyama, Tomoki; Fukushi, Keisuke

    2016-10-01

    Mobility of Pb(II) in surface condition is governed by adsorption processes on soil minerals such as iron oxides and low-crystalline aluminum silicates. The adsorption effectiveness and the surface complex structures of Pb(II) vary sensitively with solution conditions such as pH, ionic strength, Pb(II) loading, and electrolyte anion type. This study was undertaken to construct a quantitative model for Pb(II) on soil minerals. It can predict the adsorption effectiveness and surface complex structures under any solution conditions using the extended triple layer model (ETLM). The Pb(II) adsorption data for goethite, hydrous ferric oxide (HFO), quartz, and low-crystalline aluminum silicate (LCAS) were analyzed with ETLM to retrieve the surface complexation reactions and these equilibrium constants. The adsorption data on goethite, HFO and quartz were referred from reports of earlier studies. Those data for LCAS were measured under a wide range of pH, ionic strength and Pb(II) loadings in NaNO3 and NaCl solutions. All adsorption data can be reasonably regressed using ETLM with the assumptions of inner sphere bidentate complexation and inner sphere monodentate ternary complexation with electrolyte anions, which are consistent with previously reported spectroscopic evidence. Predictions of surface speciation under widely various solution conditions using ETLM revealed that the inner sphere bidentate complex is the predominant species at neutral to high pH conditions. The inner sphere monodentate ternary complex becomes important at low pH, high surface Pb(II) coverage, and high electrolyte concentrations, of which the behavior is consistent with the spectroscopic observation. Comparisons of the obtained adsorption constants on goethite, HFO and quartz exhibited good linear relations between the reciprocals of dielectric constants of solids and adsorption constants. Those linear relations support predictions of the adsorption constants of all oxides based on Born

  4. ADME Properties Evaluation in Drug Discovery: Prediction of Caco-2 Cell Permeability Using a Combination of NSGA-II and Boosting.

    Science.gov (United States)

    Wang, Ning-Ning; Dong, Jie; Deng, Yin-Hua; Zhu, Min-Feng; Wen, Ming; Yao, Zhi-Jiang; Lu, Ai-Ping; Wang, Jian-Bing; Cao, Dong-Sheng

    2016-04-25

    The Caco-2 cell monolayer model is a popular surrogate in predicting the in vitro human intestinal permeability of a drug due to its morphological and functional similarity with human enterocytes. A quantitative structure-property relationship (QSPR) study was carried out to predict Caco-2 cell permeability of a large data set consisting of 1272 compounds. Four different methods including multivariate linear regression (MLR), partial least-squares (PLS), support vector machine (SVM) regression and Boosting were employed to build prediction models with 30 molecular descriptors selected by nondominated sorting genetic algorithm-II (NSGA-II). The best Boosting model was obtained finally with R(2) = 0.97, RMSEF = 0.12, Q(2) = 0.83, RMSECV = 0.31 for the training set and RT(2) = 0.81, RMSET = 0.31 for the test set. A series of validation methods were used to assess the robustness and predictive ability of our model according to the OECD principles and then define its applicability domain. Compared with the reported QSAR/QSPR models about Caco-2 cell permeability, our model exhibits certain advantage in database size and prediction accuracy to some extent. Finally, we found that the polar volume, the hydrogen bond donor, the surface area and some other descriptors can influence the Caco-2 permeability to some extent. These results suggest that the proposed model is a good tool for predicting the permeability of drug candidates and to perform virtual screening in the early stage of drug development.

  5. An evaluation of the accuracy of the ORange® (Gen II) by comparing it to the IOLMaster® in the prediction of postoperative refraction

    Science.gov (United States)

    Chen, Ming

    2012-01-01

    Purpose The aim of this study was to evaluate the accuracy of ORange® Gen II (WaveTec Vision, Aliso Viejo, CA). Setting The Surgical Suites, Honolulu, HI. Methods The prospective 28 consecutive cataract surgical cases were selected from 85 cataract surgical cases between December 16, 2010 and February 24, 2011. With the same intraocular lens implantation, the predicted spherical equivalent refraction from IOLMaster® (Carl Zeiss AG, Oberkochen, Germany) and ORange Gen II were statistically compared and verified with 1-month postoperative manifest refraction. The data were put into IBM SPSS 19 (SPSS Inc, Chicago, IL) for analysis of variance. Pearson’s correlation coefficient was also calculated to evaluate the correlation between the IOLMaster, ORange Gen II, and 1-month postoperative manifest refraction. Results There were no statistically significant differences in the mean spherical equivalent refraction from the IOLMaster, ORange Gen II, and 1-month postoperative manifest refraction (IOLMaster −0.40 diopters, P = 0.07; ORange Gen II −0.43 diopters, P = 0.16; 1-month refraction −0.41 diopters, P = 0.07). Pearson’s correlation study demonstrated that all three were positively correlated (P refraction (r = +0.6, P < 0.01). Conclusion The ORange Gen II can be considered as an alternative method for intraocular lens selection for cataract patients. PMID:22457590

  6. An evaluation of the accuracy of the ORange (Gen II) by comparing it to the IOLMaster in the prediction of postoperative refraction.

    Science.gov (United States)

    Chen, Ming

    2012-01-01

    The aim of this study was to evaluate the accuracy of ORange(®) Gen II (WaveTec Vision, Aliso Viejo, CA). The Surgical Suites, Honolulu, HI. The prospective 28 consecutive cataract surgical cases were selected from 85 cataract surgical cases between December 16, 2010 and February 24, 2011. With the same intraocular lens implantation, the predicted spherical equivalent refraction from IOLMaster(®) (Carl Zeiss AG, Oberkochen, Germany) and ORange Gen II were statistically compared and verified with 1-month postoperative manifest refraction. The data were put into IBM SPSS 19 (SPSS Inc, Chicago, IL) for analysis of variance. Pearson's correlation coefficient was also calculated to evaluate the correlation between the IOLMaster, ORange Gen II, and 1-month postoperative manifest refraction. There were no statistically significant differences in the mean spherical equivalent refraction from the IOLMaster, ORange Gen II, and 1-month postoperative manifest refraction (IOLMaster -0.40 diopters, P = 0.07; ORange Gen II -0.43 diopters, P = 0.16; 1-month refraction -0.41 diopters, P = 0.07). Pearson's correlation study demonstrated that all three were positively correlated (P refraction (r = +0.6, P < 0.01). The ORange Gen II can be considered as an alternative method for intraocular lens selection for cataract patients.

  7. Field studies at the Apache Leap Research Site in support of alternative conceptual models

    Energy Technology Data Exchange (ETDEWEB)

    Woodhouse, E.G.; Davidson, G.R.; Theis, C. [eds.] [and others

    1997-08-01

    This is a final technical report for a project of the U.S Nuclear Regulatory Commission (sponsored contract NRC-04-090-51) with the University of Arizona. The contract was an optional extension that was initiated on July 21, 1994 and that expired on May 31, 1995. The project manager was Thomas J. Nicholson, Office of Nuclear Regulatory Research. The objectives of this contract were to examine hypotheses and conceptual models concerning unsaturated flow and transport through fractured rock, and to design and execute confirmatory field and laboratory experiments to test these hypotheses and conceptual models at the Apache Leap Research Site near Superior, Arizona. The results discussed here are products of specific tasks that address a broad spectrum of issues related to flow and transport through fractures. Each chapter in this final report summarizes research related to a specific set of objectives and can be read and interpreted as a separate entity. The tasks include detection and characterization of historical rapid fluid flow through fractured rock and the relationship to perched water systems using environmental isotopic tracers of {sup 3}H and {sup 14}C, fluid- and rock-derived {sup 2343}U/{sup 238}U measurements, and geophysical data. The water balance in a small watershed at the ALRS demonstrates the methods of acounting for ET, and estimating the quantity of water available for infiltration through fracture networks. Grain density measurements were made for core-sized samples using a newly designed gas pycnometer. The distribution and magnitude of air permeability measurements have been measured in a three-dimensional setting; the subsequent geostatistical analysis is presented. Electronic versions of the data presented here are available from authors; more detailed discussions and analyses are available in technical publications referenced herein, or soon to appear in the professional literature.

  8. 急性重型颅脑损伤患者血乳酸水平与APACHE Ⅱ评分相关性分析

    Institute of Scientific and Technical Information of China (English)

    张涛; 朱明艳

    2012-01-01

    目的 观察急性颅脑损伤患者血乳酸水平的变化及其与急性生理学与慢性健康状况评分(APACHE Ⅱ评分)的关系及意义.方法 对63例急性颅脑损伤患者在24小时内分别进行APACHE Ⅱ评分和血乳酸水平测定,比较不同组APACHE Ⅱ评分分值与血乳酸水平.结果 APACHE Ⅱ评分<10分与10~20分组间血乳酸水平差异无显著性,而APACHE Ⅱ评分20~30分组血乳酸水平明显高于10~20分组,APACHE Ⅱ评分>30分组血乳酸水平明显高于20~30分组,有统计学意义(P<0.05).死亡组血乳酸水平明显高于存活组.结论 随着APACHE Ⅱ评分增高,血乳酸水平也相应增高;血乳酸水平与急性颅脑损伤病情严重程度正相关,是判断急性重度颅脑损伤严重程度的早期、敏感的指标.

  9. Vascular response to angiotensin II predicts long-term prognosis in patients undergoing coronary artery bypass grafting

    NARCIS (Netherlands)

    Harst, van der Pim; Volbeda, M.; Voors, Adriaan; Buikema, Hendrik; Wassmann, S.; Bohm, M.; Nickenig, G.; van Gilst, W.H.

    2004-01-01

    Persistent activation of the renin-angiotensin system leads to downregulation of the angiotensin type-1 receptor, and consequently, to a decreased response to exogenous angiotensin II. In the present study, we investigated the association of angiotensin II responsiveness to clinical outcome after co

  10. Effect of substituents on prediction of TLC retention of tetra-dentate Schiff bases and their Copper(II) and Nickel(II) complexes.

    Science.gov (United States)

    Stevanović, Nikola R; Perušković, Danica S; Gašić, Uroš M; Antunović, Vesna R; Lolić, Aleksandar Đ; Baošić, Rada M

    2017-03-01

    The objectives of this study were to gain insights into structure-retention relationships and to propose the model to estimating their retention. Chromatographic investigation of series of 36 Schiff bases and their copper(II) and nickel(II) complexes was performed under both normal- and reverse-phase conditions. Chemical structures of the compounds were characterized by molecular descriptors which are calculated from the structure and related to the chromatographic retention parameters by multiple linear regression analysis. Effects of chelation on retention parameters of investigated compounds, under normal- and reverse-phase chromatographic conditions, were analyzed by principal component analysis, quantitative structure-retention relationship and quantitative structure-activity relationship models were developed on the basis of theoretical molecular descriptors, calculated exclusively from molecular structure, and parameters of retention and lipophilicity. Copyright © 2016 John Wiley & Sons, Ltd.

  11. 三种方法对急性百草枯中毒严重程度和预后评估价值的比较%Predictive value of 3 methods in severity evaluation and prognosis of acute paraquat poisoning

    Institute of Scientific and Technical Information of China (English)

    杜宇; 牟奕

    2013-01-01

    目的:比较入院时血浆百草枯浓度、百草枯中毒严重指数(SIPP)及急性生理学及慢性健康状况评分II (APACHE II)3种评估方法在急性百草枯中毒严重度和预后评估中的价值。方法:采集73例口服急性百草枯中毒患者入院时血浆百草枯浓度及各项临床资料计算SIPP和APACHE II,根据患者医院内及出院7 d内的预后结果对3种评估方法进行分辨度和校准度检验,以此评估预测价值。结果:3种评估方法均有较好的分辨度(>0.8),其中SIPP的ROC曲线下面积(0.938)均大于血浆百草枯浓度(0.857)和APACHE II (0.801),且差异有统计学意义(z=2.429,2.021;P=0.015,0.043),而后两者差异无统计学意义(z=0.755,P=0.450)。Hosmer-Lemeshow拟合优度检验显示三者均有较好的校准度(P>0.05)。结论:3种评估方法均可用于急性百草枯中毒严重度和预后评估,但SIPP比其他两个评估方法更具优势,入院时血浆百草枯浓度相对次之,但在没有条件实施血浆百草枯浓度测定的医疗机构也可采用APACHE II为急性百草枯中毒预后评估提供参考。%Objective:To evaluate the predictive value of 3 methods, namely plasma paraquat concentration, severity index of paraquat poisoning (SIPP), and acute physiology and chronic health evaluation (APACHE II) in severity evaluation and prognosis of acute paraquat poisoning. Methods:A total of 73 acute paraquat poisoning patients with oral administration were collected. Paraquat concentration in the plasma and other parameters on admission for SIPP and APACHE II were taken from medical records. According to the clinical outcome in the hospital or 7 days atfer the discharge, discrimination and calibration test were performed to evaluate the prognosis of the 3 methods. Results:Discrimination of the 3 methods was greater than 0.8, and the area under the receiver operator curve for SIPP (0.938) was greater than paraquat concentration in the

  12. In silico prediction of drug dissolution and absorption with variation in intestinal pH for BCS class II weak acid drugs: ibuprofen and ketoprofen.

    Science.gov (United States)

    Tsume, Yasuhiro; Langguth, Peter; Garcia-Arieta, Alfredo; Amidon, Gordon L

    2012-10-01

    The FDA Biopharmaceutical Classification System guidance allows waivers for in vivo bioavailability and bioequivalence studies for immediate-release solid oral dosage forms only for BCS class I. Extensions of the in vivo biowaiver for a number of drugs in BCS class III and BCS class II have been proposed, in particular, BCS class II weak acids. However, a discrepancy between the in vivo BE results and in vitro dissolution results for BCS class II acids was recently observed. The objectives of this study were to determine the oral absorption of BCS class II weak acids via simulation software and to determine if the in vitro dissolution test with various dissolution media could be sufficient for in vitro bioequivalence studies of ibuprofen and ketoprofen as models of carboxylic acid drugs. The oral absorption of these BCS class II acids from the gastrointestinal tract was predicted by GastroPlus™. Ibuprofen did not satisfy the bioequivalence criteria at lower settings of intestinal pH of 6.0. Further the experimental dissolution of ibuprofen tablets in a low concentration phosphate buffer at pH 6.0 (the average buffer capacity 2.2 mmol l (-1) /pH) was dramatically reduced compared with the dissolution in SIF (the average buffer capacity 12.6 mmol l (-1) /pH). Thus these predictions for the oral absorption of BCS class II acids indicate that the absorption patterns depend largely on the intestinal pH and buffer strength and must be considered carefully for a bioequivalence test. Simulation software may be a very useful tool to aid the selection of dissolution media that may be useful in setting an in vitro bioequivalence dissolution standard.

  13. Evaluation of the Prognosis for Elderly Critical Patients in Emergency Department Using MEWS Score and APACHE Ⅱ Score%MEWS评分和APACHE Ⅱ评分对急诊老年危重症患者预后的评估

    Institute of Scientific and Technical Information of China (English)

    刘静波; 黄萍

    2013-01-01

    Objective To study the assessment value of Modified Early Warning Score( MEWS ) and Acute Physiology and Chronic Health Evaluation( APACHE Ⅱ ) score for the prognosis of critical elderly patients in emergency department. Methods 158 elderly patients from emergency ICL of Xuanwu Hospital of Capital Lniversity of Medical Sciences were collected. MEW S score and APACHE Ⅱ score were calculated for them and the differences were compared between death group and survival group. The difference of the area under receiver operating characteristic curve( ALROCC ) were compared between MEWS score and APACHE Ⅱ score. The death rate were analyzed in the different groups with MEW S score ≤3 ,4-6 ,7-9 ,and ≥ 10 respectively. The correlation analysis of MEW S score and APACHE Ⅱ score was done. Results MEWS score and APACHE Ⅱ score in death group were 8.06 ±2.71 and 24.60 ±4.20 respectively,those in survival group were 4. 80 ±2. 47 and 19. 06 ± 3. 93 respectively P 0. 05 ). With MEWS increasing, the fatality rose( P < 0. 01 ). MEWS score and APACHE Ⅱ score were correlated ( r-0. 647 ,P-0.001 ). Conclusion MEWS score,as well as APACHE Ⅱ score,is a convenient and fast scoring system,with which the disease condition and prognosis of critical elderly patients can be assessed.%目的 研究改良早期预警评分(MEWS)和急性生理与慢性健康状况评估(APACHE Ⅱ)评分对急诊老年危重症患者预后的评估价值.方法 收集首都医科大学宣武医院急诊监护室老年患者158例,入院后分别给予MEWS评分与APACHE Ⅱ评分,比较死亡组与存活组MEWS评分、APACHE Ⅱ评分的差别,分别比较MEWS评分与APACHE Ⅱ评分受试者工作特征曲线(ROC)下面积的区别及MEWS评分≤3分、4 ~6分,7 ~9分、≥10分患者病死率的区别,研究MEWS评分与APACHE Ⅱ评分的相关性.结果 死亡组MEWS评分和APACHE Ⅱ评分分别为(8.06±2.71)分和(24.60±4.20)分,存活组分别为(4.80±2.47)分和(19.06±3

  14. 创伤性休克APACHE评分与血乳酸变化的临床研究%Traumatic shock and APACHE score and blood lactate changes in clinical research

    Institute of Scientific and Technical Information of China (English)

    郭福东; 杨淑霞

    2012-01-01

    Objective To study APACHE score in patients with traumatic shock and blood lactate changes in treatment and prognosis significance.Methods hospital emergency surgery from March 2007 to August 2011 period,enter the emergency intensive care unit of a continuous 80 cases of patients with post-traumatic hypovolemic shock.Routine use of bleeding in all cases,add volume,catecholamines,blood pressure refers to the ECG monitor and a stable pulse oxygen and other recovery measures within the environment,determine the initial, 12,24,48 h changes in blood lactate and APACHE II scores within each 24h,compare the survival group and death group data. Results survival group of 68 patients (85%), 12 cases of death. Conclusion APACHE score and dynamic monitoring of blood lactate could be used as treatment of patients with hemorrhagic shock and an important prognostic indicator.%目的 研究创伤性休克患者APACHE评分和血乳酸含量变化对临床疗效及预后判断的影响.方法 回顾我院急诊外科2007年3月至2011年8月期间,进入急诊重症监护室的连续80例创伤后低血容量体克患者.对所有病例常规采用止血、补充血容量、儿茶酚胺类药物、心电、血压、指脉氧等监测以及稳定内环境等复苏措施,测定初始、12、24、48 h血乳酸变化以及每24h内APACHEⅡ评分,分存活组与死亡组,比较存活组与死亡组资料.结果存活组68例为85%;死亡组12例为15%.结论APACHE评分及动态监测及乳酸可作为判断失血性休克患者治疗效果以及预后的重要指标.

  15. Meeting Report: FutureTox II: Contemporary Concepts in Toxicology “Pathways to Prediction: In Vitro and In Silico Models for Predictive Toxicology”

    Science.gov (United States)

    The Society of Toxicology (SOT) held avery successful FutureTox II Contemporary Concepts in Toxicology (CCT) Conference in Chapel Hill, North Carolina, on January 16th and 17th, 2014. There were over 291 attendees representing industry, government and academia; the sessions were ...

  16. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.

    Science.gov (United States)

    Shi, Leming; Campbell, Gregory; Jones, Wendell D; Campagne, Fabien; Wen, Zhining; Walker, Stephen J; Su, Zhenqiang; Chu, Tzu-Ming; Goodsaid, Federico M; Pusztai, Lajos; Shaughnessy, John D; Oberthuer, André; Thomas, Russell S; Paules, Richard S; Fielden, Mark; Barlogie, Bart; Chen, Weijie; Du, Pan; Fischer, Matthias; Furlanello, Cesare; Gallas, Brandon D; Ge, Xijin; Megherbi, Dalila B; Symmans, W Fraser; Wang, May D; Zhang, John; Bitter, Hans; Brors, Benedikt; Bushel, Pierre R; Bylesjo, Max; Chen, Minjun; Cheng, Jie; Cheng, Jing; Chou, Jeff; Davison, Timothy S; Delorenzi, Mauro; Deng, Youping; Devanarayan, Viswanath; Dix, David J; Dopazo, Joaquin; Dorff, Kevin C; Elloumi, Fathi; Fan, Jianqing; Fan, Shicai; Fan, Xiaohui; Fang, Hong; Gonzaludo, Nina; Hess, Kenneth R; Hong, Huixiao; Huan, Jun; Irizarry, Rafael A; Judson, Richard; Juraeva, Dilafruz; Lababidi, Samir; Lambert, Christophe G; Li, Li; Li, Yanen; Li, Zhen; Lin, Simon M; Liu, Guozhen; Lobenhofer, Edward K; Luo, Jun; Luo, Wen; McCall, Matthew N; Nikolsky, Yuri; Pennello, Gene A; Perkins, Roger G; Philip, Reena; Popovici, Vlad; Price, Nathan D; Qian, Feng; Scherer, Andreas; Shi, Tieliu; Shi, Weiwei; Sung, Jaeyun; Thierry-Mieg, Danielle; Thierry-Mieg, Jean; Thodima, Venkata; Trygg, Johan; Vishnuvajjala, Lakshmi; Wang, Sue Jane; Wu, Jianping; Wu, Yichao; Xie, Qian; Yousef, Waleed A; Zhang, Liang; Zhang, Xuegong; Zhong, Sheng; Zhou, Yiming; Zhu, Sheng; Arasappan, Dhivya; Bao, Wenjun; Lucas, Anne Bergstrom; Berthold, Frank; Brennan, Richard J; Buness, Andreas; Catalano, Jennifer G; Chang, Chang; Chen, Rong; Cheng, Yiyu; Cui, Jian; Czika, Wendy; Demichelis, Francesca; Deng, Xutao; Dosymbekov, Damir; Eils, Roland; Feng, Yang; Fostel, Jennifer; Fulmer-Smentek, Stephanie; Fuscoe, James C; Gatto, Laurent; Ge, Weigong; Goldstein, Darlene R; Guo, Li; Halbert, Donald N; Han, Jing; Harris, Stephen C; Hatzis, Christos; Herman, Damir; Huang, Jianping; Jensen, Roderick V; Jiang, Rui; Johnson, Charles D; Jurman, Giuseppe; Kahlert, Yvonne; Khuder, Sadik A; Kohl, Matthias; Li, Jianying; Li, Li; Li, Menglong; Li, Quan-Zhen; Li, Shao; Li, Zhiguang; Liu, Jie; Liu, Ying; Liu, Zhichao; Meng, Lu; Madera, Manuel; Martinez-Murillo, Francisco; Medina, Ignacio; Meehan, Joseph; Miclaus, Kelci; Moffitt, Richard A; Montaner, David; Mukherjee, Piali; Mulligan, George J; Neville, Padraic; Nikolskaya, Tatiana; Ning, Baitang; Page, Grier P; Parker, Joel; Parry, R Mitchell; Peng, Xuejun; Peterson, Ron L; Phan, John H; Quanz, Brian; Ren, Yi; Riccadonna, Samantha; Roter, Alan H; Samuelson, Frank W; Schumacher, Martin M; Shambaugh, Joseph D; Shi, Qiang; Shippy, Richard; Si, Shengzhu; Smalter, Aaron; Sotiriou, Christos; Soukup, Mat; Staedtler, Frank; Steiner, Guido; Stokes, Todd H; Sun, Qinglan; Tan, Pei-Yi; Tang, Rong; Tezak, Zivana; Thorn, Brett; Tsyganova, Marina; Turpaz, Yaron; Vega, Silvia C; Visintainer, Roberto; von Frese, Juergen; Wang, Charles; Wang, Eric; Wang, Junwei; Wang, Wei; Westermann, Frank; Willey, James C; Woods, Matthew; Wu, Shujian; Xiao, Nianqing; Xu, Joshua; Xu, Lei; Yang, Lun; Zeng, Xiao; Zhang, Jialu; Zhang, Li; Zhang, Min; Zhao, Chen; Puri, Raj K; Scherf, Uwe; Tong, Weida; Wolfinger, Russell D

    2010-08-01

    Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis.

  17. Crack Growth Modeling and Life Prediction of Pipeline Steels Exposed to Near-Neutral pH Environments: Stage II Crack Growth and Overall Life Prediction

    Science.gov (United States)

    Zhao, Jiaxi; Chen, Weixing; Yu, Mengshan; Chevil, Karina; Eadie, Reg; Been, Jenny; Van Boven, Greg; Kania, Richard; Keane, Sean

    2017-04-01

    This investigation was initiated to provide governing equations for crack initiation, crack growth, and service life prediction of pipeline steels in near-neutral pH (NNpH) environments. This investigation develops a predictive model considering loading interactions occurring during oil and gas pipeline operation with underload-type variable pressure fluctuations. This method has predicted lifetimes comparable to the actual service lives found in the field. This is in sharp contrast with the predictions made by existing methods that are either conservative or inconsistent with the field observations. It has been demonstrated that large slash loads ( R-ratio is 0.05), often seen during gas pipeline operation, are a major life-limiting factor and should be avoided where possible. Oil pipelines have shorter lifetime because of their more frequent pressure fluctuations and larger amplitude load cycles. The accuracy of prediction can be improved if pressure data with appropriate sampling intervals are used. The sampling interval error is much larger in the prediction of oil pipelines than gas pipelines because of their different compressibility but is minimized if the pressure sampling rate for the data is at or less than one minute.

  18. Predictive value of PET-CT for pathological response in stages II and III breast cancer patients following neoadjuvant chemotherapy with docetaxel.

    Science.gov (United States)

    García García-Esquinas, Marta A; Arrazola García, Juan; García-Sáenz, José A; Furió-Bacete, V; Fuentes Ferrer, Manuel E; Ortega Candil, Aída; Cabrera Martín, María N; Carreras Delgado, José L

    2014-01-01

    To prospectively study the value of PET-CT with fluorine-18 fluorodeoxyglucose (FDG) to predict neoadjuvant chemotherapy (NAC) response of locoregional disease of stages II and III breast cancer patients. A written informed consent and approval were obtained from the Ethics Committee. PET-CT accuracy in the prediction of pathologic complete response (pCR) after NAC was studied in primary tumors and lymph node metastasis in 43 women (mean age: 50 years: range: 27-71 years) with histologically proven breast cancer between December 2009 and January 2011. PET-CT was performed at baseline and after NAC. SUV(max) percentage changes (ΔSUV(max)) were compared with pathology findings at surgery. Receiver-operator characteristic (ROC) analysis was used to discriminate between locoregional pCR and non-pCR. In patients not achieving pCR, it was investigated if ΔSUV(max) could accurately identify the residual cancer burden (RCB) classes: RCB-I (minimal residual disease (MRD)), RCB-II (moderate RD), and RCB-III (extensive RD). pCR was obtained in 11 patients (25.6%). Residual disease was found in 32 patients (74.4%): 16 (37.2%) RCB-I, 15 (35.6%) RCB-II and 2 (4.7%) RCB-III. Sensitivity, specificity, and accuracy to predict pCR were 90.9%, 90.6%, and 90.7%, respectively. Specificity was 94.1% in the identification of a subset of patients who had either pCR or MRD. Accuracy of ΔSUV(max) in the locoregional disease of stages II and III breast cancer patients after NAC is high for the identification of pCR cases. Its specificity is potentially sufficient to identify a subgroup of patients who could be managed with conservative surgery. Copyright © 2013 Elsevier España, S.L. and SEMNIM. All rights reserved.

  19. Prediction of Outcome in Neonates with Hypoxic-Ischemic Encephalopathy II: Role of Amplitude-Integrated Electroencephalography and Cerebral Oxygen Saturation Measured by Near-Infrared Spectroscopy.

    Science.gov (United States)

    Goeral, Katharina; Urlesberger, Berndt; Giordano, Vito; Kasprian, Gregor; Wagner, Michael; Schmidt, Lisa; Berger, Angelika; Klebermass-Schrehof, Katrin; Olischar, Monika

    2017-07-14

    Few data have been published on the combined use of amplitude-integrated electroencephalography (aEEG) and near-infrared spectroscopy (NIRS) for outcome prediction in neonates cooled for hypoxic-ischemic encephalopathy (HIE). Our aim was to evaluate the predictive values and the most powerful predictive combinations of single aEEG and NIRS parameters and the respective cut-off values with regard to short-term outcomes in HIE II. aEEG and NIRS were prospectively studied at the Medical University of Vienna in the first 102 h of life with regard to magnetic resonance imaging (MRI). Thirty-two neonates diagnosed with HIE II treated with hypothermia were investigated. The measurement period was divided into 6-h epochs. According to MRI, 2 outcome groups were defined and predictive values of aEEG parameters, regional cerebral oxygen saturation (rScO2), and the additional value of both methods combined were studied. Receiver operating curves (ROC) were obtained and area under the curve (AUC) values were calculated. ROC were then used to detect the optimal cut-off points, sensitivity, specificity, positive predictive values, and negative predictive values. At all time epochs, combined parameter scores were more predictive than single parameter scores. The highest AUC were observed between 18 and 60 h of cooling for the aEEG summation score (0.72-0.84) and for (background pattern + seizures) × rScO2 (0.79-0.85). At 42-60 h sensitivity was similar between those 2 scores (87.5-90.0%), but the addition of NIRS to aEEG led to an increase in specificity (from 52.4-59.1% to 72.7-90.5%). In HIE II, aEEG and NIRS are important predictors of short-term outcome. The combination of both methods improves prognostication. The highest predictive abilities were observed between 18 and 60 h of cooling. © 2017 S. Karger AG, Basel.

  20. Development and validation of risk-stratification delirium prediction model for critically ill patients: A prospective, observational, single-center study.

    Science.gov (United States)

    Chen, Yu; Du, Hang; Wei, Bao-Hua; Chang, Xue-Ni; Dong, Chen-Ming

    2017-07-01

    The objective is to develop a model based on risk stratification to predict delirium among adult critically ill patients and whether early intervention could be provided for high-risk patients, which could reduce the incidence of delirium.We designed a prospective, observational, single-center study. We examined 11 factors, including age, APACHE-II score, coma, emergency operation, mechanical ventilation (MV), multiple trauma, metabolic acidosis, history of hypertension, delirium and dementia, and application of Dexmedetomidine Hydrochloride. Confusion assessment method for the intensive care unit (CAM-ICU) was performed to screen patients during their ICU stay. Multivariate logistic regression analysis was used to develop the model, and we assessed the predictive ability of the model by using the area under the receiver operating characteristics curve (AUROC).From May 17, 2016 to September 25, 2016, 681 consecutive patients were screened, 61 of whom were excluded. The most frequent reason for exclusion was sustained coma 30 (4.4%), followed by a length of stay in the ICU delirium before ICU admission 13 (1.9%). Among the remaining 620 patients (including 162 nervous system disease patients), 160 patients (25.8%) developed delirium, and 64 (39.5%) had nervous system disease. The mean age was 55 ± 18 years old, the mean APACHE-II score was 16 ± 4, and 49.2% of them were male. Spearman analysis of nervous system disease and incidence of delirium showed that the correlation coefficient was 0.186 (P delirium in critically ill patients and further determined that prophylaxis with Dexmedetomidine Hydrochloride in delirious ICU patients was beneficial. Patients who suffer from nervous system disease are at a higher incidence of delirium, and corresponding measures should be used for prevention. ChiCTR-OOC-16008535.

  1. The Apache Longbow-Hellfire Missile Test at Yuma Proving Ground: Ecological Risk Assessment for Helicopter Overflight

    Energy Technology Data Exchange (ETDEWEB)

    Efroymson, Rebecca Ann [ORNL; Hargrove, William Walter [ORNL; Suter, Glenn [U.S. Environmental Protection Agency

    2008-01-01

    A multi-stressor risk assessment was conducted at Yuma Proving Ground, Arizona, as a demonstration of the Military Ecological Risk Assessment Framework. The focus of the assessment was a testing program at Cibola Range, which involved an Apache Longbow helicopter firing Hellfire missiles at moving targets, M60-A1 tanks. This paper focuses on the wildlife risk assessment for the helicopter overflight. The primary stressors were sound and the view of the aircraft. Exposure to desert mule deer (Odocoileus hemionus crooki) was quantified using Air Force sound contour programs NOISEMAP and MR_NMAP, which gave very different results. Slant distance from helicopters to deer was also used as a measure of exposure that integrated risk from sound and view of the aircraft. Exposure-response models for the characterization of effects consisted of behavioral thresholds in sound exposure level or maximum sound level units or slant distance. Available sound thresholds were limited for desert mule deer, but a distribution of slant-distance thresholds was available for ungulates. The risk characterization used a weight-of-evidence approach and concluded that risk to mule deer behavior from the Apache overflight is uncertain, but that no risk to mule deer abundance and reproduction is expected.

  2. Distribution of albumin variants Naskapi amd Mexico among Aleuts, Frobisher Bay Eskimos, and Micmac, Naskapi, Mohawk, Omaha, and Apache Indians.

    Science.gov (United States)

    Schell, L M; Agarwal, S S; Blumberg, B S; Levy, H; Bennett, P H; Laughlin, W S; Martin, J P

    1978-07-01

    In order to help define the boundaries of the distribution of the albumin variants Naskapi and Mexico which are polymorphic among several American Indian groups, we examined sera from Micmac, Mohawk, Northwest River Naskapi, Omaha and Apache Indians, and from Aleuts and Eskimos. Sera from a total of 1,524 individuals were examined. Using a cellulose acetate membrane electrophoretic system with Tris-Citric acid at pH 5.4 we were able to distinguish normal albumin and both variants in the same run. Naskapi and Mexico variants were absent from Aleut, Eskimo, Micmac, Mohawk and Omaha samples. The albumin Naskapi variant was present in an allele frequency of 0.03 in the Naskapi Indian sample. Albumin variants Naskapi and Mexico were found in the Apache sample at frequencies of 0.016 and 0.037, respectively. This report supersedes that previously published by Schell and Agarwal ('76). Generally, within an area there is a correspondence between changes in the frequency of albumin variants and changes in the ethnic background and history of the area's populations. At the same time, when viewing widely separated areas, relationships between distant groups based on linguistic and cultural similarities are paralleled on a biologic level by the distribution of normal albumin and variant albumins.

  3. Landscape associations of the sand fly, Lutzomyia (Heleocyrtomyia) apache (Diptera: Psychodidae), in the southwestern United States: a geographic information system analysis.

    Science.gov (United States)

    Herrero, M V; Yarnell, W E; Schmidtmann, E T

    2004-12-01

    Landscape associations of the sand fly, Lutzomyia apache, Young and Perkins, in the southwestern U.S. were investigated by light/suction trap sampling and the development of a GIS-generated distribution map. In the mid-Rio Grande River valley, N.M., female and male L. apache were captured in updraft light/suction traps set in desert shrubland, irrigation levee, and bosque vegetation communities. Small numbers of flies were captured, but the presence of males and females in spatially separate and diverse plant communities at two locations suggest that L. apache are dispersed among available vegetation types. These data, along with 22 previously published collection site records, were used with a suite of physiographic features to characterize the biogeographic conditions suitable for L. apache. Suitable conditions encompass three life zones: the Rocky Mountain steppe province, the Colorado semi-plateau province, and the American semi-desert province, all within the dry domain region of the western U.S. The potential range of L. apache was then estimated based on elevation, mean and max - min temperature, precipitation, wet days, and relative humidity. The estimated range includes large contiguous areas in north-central Colorado, east-central New Mexico and west Texas, the lower mid-Rio Grande River valley, and southern Arizona, along with smaller, patchy, areas in northern Arizona, California, Nevada, Utah, and central Idaho. The spatial relationship between the estimated distribution of L. apache and the location of livestock exposed to vesicular stomatitis virus at the onset of recent outbreaks is presented.

  4. Miniscrew-assisted customized lingual appliances for predictable treatment of skeletal Class II malocclusion with severe deep overbite and overjet.

    Science.gov (United States)

    Wang, Xue-Dong; Lei, Fei-Fei; Liu, Da-Wei; Zhang, Jie-Ni; Liu, Wei-Tao; Song, Yang; Zhou, Yan-Heng

    2017-07-01

    This report describes the use of miniscrew-assisted customized lingual fixed appliances in a patient with severe skeletal Class II malocclusion. The patient was a 12-year-old Chinese girl with the chief complaint of protrusive lips and anterior teeth. Her diagnosis included a skeletal Class II relationship with maxillary protrusion, a backward-rotated mandible, a full Angle Class II molar relationship, and severe deep overjet and overbite. Four premolars were extracted, and miniscrew anchorage was placed in the maxillary posterior lingual segment to provide maximum anchorage and to achieve vertical control of the intruding molars. The customized lingual fixed appliance and temporary anchorage devices created a smooth and invisible treatment progress, resulting ultimately in a well-aligned dentition with ideal intercuspation and a dramatically improved profile. The 3-year follow-up examination indicated that the excellent treatment outcome was stable. Copyright © 2017 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  5. A scoring system based on artificial neural network for predicting 10-year survival in stage II A colon cancer patients after radical surgery.

    Science.gov (United States)

    Peng, Jian-Hong; Fang, Yu-Jing; Li, Cai-Xia; Ou, Qing-Jian; Jiang, Wu; Lu, Shi-Xun; Lu, Zhen-Hai; Li, Pei-Xing; Yun, Jing-Ping; Zhang, Rong-Xin; Pan, Zhi-Zhong; Wan, De Sen

    2016-04-19

    Nearly 20% patients with stage II A colon cancer will develop recurrent disease post-operatively. The present study aims to develop a scoring system based on Artificial Neural Network (ANN) model for predicting 10-year survival outcome. The clinical and molecular data of 117 stage II A colon cancer patients from Sun Yat-sen University Cancer Center were used for training set and test set; poor pathological grading (score 49), reduced expression of TGFBR2 (score 33), over-expression of TGF-β (score 45), MAPK (score 32), pin1 (score 100), β-catenin in tumor tissue (score 50) and reduced expression of TGF-β in normal mucosa (score 22) were selected as the prognostic risk predictors. According to the developed scoring system, the patients were divided into 3 subgroups, which were supposed with higher, moderate and lower risk levels. As a result, for the 3 subgroups, the 10-year overall survival (OS) rates were 16.7%, 62.9% and 100% (P < 0.001); and the 10-year disease free survival (DFS) rates were 16.7%, 61.8% and 98.8% (P < 0.001) respectively. It showed that this scoring system for stage II A colon cancer could help to predict long-term survival and screen out high-risk individuals for more vigorous treatment.

  6. Perform wordcount Map-Reduce Job in Single Node Apache Hadoop cluster and compress data using Lempel-Ziv-Oberhumer (LZO algorithm

    Directory of Open Access Journals (Sweden)

    Nandan Nagarajappa Mirajkar

    2013-01-01

    Full Text Available Applications like Yahoo, Facebook, Twitter have huge data which has to be stored and retrieved as per client access. This huge data storage requires huge database leading to increase in physical storage and becomes complex for analysis required in business growth. This storage capacity can be reduced and distributed processing of huge data can be done using Apache Hadoop which uses Map-reduce algorithm and combines the repeating data so that entire data is stored in reduced format. The paper describes performing a wordcount Map-Reduce Job in Single Node Apache Hadoop cluster and compress data using Lempel-Ziv-Oberhumer (LZO algorithm.

  7. Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation

    Directory of Open Access Journals (Sweden)

    Yoon Jung-Hwan

    2011-10-01

    Full Text Available Abstract Background Clinicians often experience extrahepatic metastases associated with hepatocellular carcinoma (HCC, even if no evidence of intrahepatic recurrence after treatment is observed. We investigated the pretreatment predictors of extrahepatic metastases in HCC patients. Methods Patients diagnosed with HCC without evidence of extrahepatic metastases were prospectively enrolled. We evaluated the correlation between extrahepatic metastases and pretreatment clinical variables, including serum tumor markers. Results A total of 354 patients were included. Seventy-six patients (21% had extrahepatic metastases during the observation period (median, 25.3 months; range, 0.6-51.3 months. Cox regression multivariate analysis showed that serum protein induced by vitamin K absence or antagonist-II (PIVKA-II production levels, the intrahepatic tumor stage, platelet count, and portal vein thrombosis were independent risk factors for extrahepatic metastases. Patients with a PIVKA-II production ≥ 300 mAU/mL had a 2.7-fold (95% confidence interval; 1.5-4.8; P Conclusion PIVKA-II production levels might be a good candidate predictive marker for extrahepatic HCC metastases, especially in patients with smaller and/or fewer tumors in the liver with in stages regardless of serum alpha-fetoprotein.

  8. Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia

    NARCIS (Netherlands)

    M.M. van Luijn (Marvin M.); W. van den Ancker (Willemijn); S.M. van Ham (Marieke); A.A. van de Loosdrecht (Arjan)

    2014-01-01

    textabstractThe majority of patients with acute myeloid leukemia (AML) reach complete remission after high-dose chemotherapy. Still, half of these patients experience a relapse due to presence of minimal residual disease (MRD). Here we discuss the poor prognostic role of class II-associated

  9. Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia

    NARCIS (Netherlands)

    M.M. van Luijn (Marvin M.); W. van den Ancker (Willemijn); S.M. van Ham (Marieke); A.A. van de Loosdrecht (Arjan)

    2014-01-01

    textabstractThe majority of patients with acute myeloid leukemia (AML) reach complete remission after high-dose chemotherapy. Still, half of these patients experience a relapse due to presence of minimal residual disease (MRD). Here we discuss the poor prognostic role of class II-associated invarian

  10. Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia

    OpenAIRE

    van Luijn, Marvin M.; van den Ancker, Willemijn; van Ham, S Marieke; Arjan A. van de Loosdrecht

    2014-01-01

    The majority of patients with acute myeloid leukemia (AML) reach complete remission after high-dose chemotherapy. Still, half of these patients experience a relapse due to presence of minimal residual disease (MRD). Here we discuss the poor prognostic role of class II-associated invariant chain peptide (CLIP) expression on residual leukemic cells.

  11. Oncotype DX(®) colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: A review of the evidence.

    Science.gov (United States)

    You, Y Nancy; Rustin, Rudolph B; Sullivan, James D

    2015-06-01

    Advances in molecular biology have enabled identification of tumor biomarkers that allow for individualized risk assessment for patients with cancer. Molecular predictors of clinical outcome can help inform discussion regarding the role of adjuvant chemotherapy in patients with resected colon cancer, such as those with stage II colon cancer in which the benefit of adjuvant therapy is controversial or those with stage III colon cancer who may have a lower risk of recurrence and less absolute benefit from oxaliplatin therapy. This article summarizes the data surrounding the development, validation, and clinical and economic utility of the Oncotype DX(®) colon cancer assay, a multigene expression assay validated to independently predict recurrence risk in patients with stage II and III colon cancer beyond traditional factors.

  12. Prediction of logP for Pt(II) and Pt(IV) complexes: Comparison of statistical and quantum-chemistry based approaches.

    Science.gov (United States)

    Tetko, Igor V; Varbanov, Hristo P; Galanski, Markus; Talmaciu, Mona; Platts, James A; Ravera, Mauro; Gabano, Elisabetta

    2016-03-01

    The octanol/water partition coefficient, logP, is one of the most important physico-chemical parameters for the development of new metal-based anticancer drugs with improved pharmacokinetic properties. This study addresses an issue with the absence of publicly available models to predict logP of Pt(IV) complexes. Following data collection and subsequent development of models based on 187 complexes from literature, we validate new and previously published models on a new set of 11 Pt(II) and 35 Pt(IV) complexes, which were kept blind during the model development step. The error of the consensus model, 0.65 for Pt(IV) and 0.37 for Pt(II) complexes, indicates its good accuracy of predictions. The lower accuracy for Pt(IV) complexes was attributed to experimental difficulties with logP measurements for some poorly-soluble compounds. This model was developed using general-purpose descriptors such as extended functional groups, molecular fragments and E-state indices. Surprisingly, models based on quantum-chemistry calculations provided lower prediction accuracy. We also found that all the developed models strongly overestimate logP values for the three complexes measured in the presence of DMSO. Considering that DMSO is frequently used as a solvent to store chemicals, its effect should not be overlooked when logP measurements by means of the shake flask method are performed. The final models are freely available at http://ochem.eu/article/76903.

  13. The value of myocardium enzyme and APACHE Ⅱ score in the prognosis of ICU patients without AMI%心肌酶与APACHE Ⅱ评分在ICU非心肌梗死患者预后中的价值

    Institute of Scientific and Technical Information of China (English)

    朱建辉; 吴政庚; 李晓斌; 李福强

    2011-01-01

    目的 探讨心肌酶与APACHE Ⅱ评分在ICU非心肌梗死(AMI)患者预后中的价值及其相关性.方法 从2007年11月至2010年10月入住本院ICU的非AMI患者中随机选取199例,其中存活132例(存活组),死亡67例(死亡组),均于入院时进行APACHE Ⅱ评分,24 h内常规检测各项心肌酶指标.比较2组患者心肌酶测定结果、APACHE Ⅱ评分,以及心肌酶各项指标与APACHE Ⅱ评分的相关性.结果 死亡组心肌酶各项指标明显高于存活组,2组间比较差异有统计学意义(P<0.01);存活组APACHE Ⅱ(12.70±7.85)分,低于死亡组的(24.80±7.46)分,2组间比较差异有统计学意义(P<0.01);心肌酶各项指标与APACHE Ⅱ评分均呈高度正相关.结论 心肌酶和APACHE Ⅱ评分反映出ICU非AMI患者疾病的严重程度和转归,均可作为评估患者预后的参考指标之一.%Objective To investigate the clinical value of and correlation between myocardium enzymes and APACHE Ⅱ score in the prognosis o~ intensive care unit(ICU) patients without AMI. Methods During Nov. 2007 to Oct. 2010,199 cases of ICU pa tients without AMI in our hospital were selected randomly,among which 132 cases survived(survival group)and 67 cases were dead (death group). APACHE Ⅱ score at admission and myocardium enzymes detection in 24 hours were carried out. The detection re sults of myocardium enzymes and APACHE Ⅱ score were compared between the two groups and the correlation between various myocardium enzymes and APACHE Ⅱ was analyzed. Results Serum levels of all myocardium enzymes in the death group were significantly higher than those in the survival group(P<0.01). APACHE Ⅱ score of the death group were significantly higher than that of the survival group (P<0.01). There was fine correlation between various myocardium enzymes and APACHE Ⅱ score. Conclusion Myocardium enzymes and APACHE Ⅱ score can reflect the severity and turnover of the diseases and can be used for the prognosis of

  14. Experimental analysis and mathematical prediction of Cd(II) removal by biosorption using support vector machines and genetic algorithms.

    Science.gov (United States)

    Hlihor, Raluca Maria; Diaconu, Mariana; Leon, Florin; Curteanu, Silvia; Tavares, Teresa; Gavrilescu, Maria

    2015-05-25

    We investigated the bioremoval of Cd(II) in batch mode, using dead and living biomass of Trichoderma viride. Kinetic studies revealed three distinct stages of the biosorption process. The pseudo-second order model and the Langmuir model described well the kinetics and equilibrium of the biosorption process, with a determination coefficient, R(2)>0.99. The value of the mean free energy of adsorption, E, is less than 16 kJ/mol at 25 °C, suggesting that, at low temperature, the dominant process involved in Cd(II) biosorption by dead T. viride is the chemical ion-exchange. With the temperature increasing to 40-50 °C, E values are above 16 kJ/mol, showing that the particle diffusion mechanism could play an important role in Cd(II) biosorption. The studies on T. viride growth in Cd(II) solutions and its bioaccumulation performance showed that the living biomass was able to bioaccumulate 100% Cd(II) from a 50 mg/L solution at pH 6.0. The influence of pH, biomass dosage, metal concentration, contact time and temperature on the bioremoval efficiency was evaluated to further assess the biosorption capability of the dead biosorbent. These complex influences were correlated by means of a modeling procedure consisting in data driven approach in which the principles of artificial intelligence were applied with the help of support vector machines (SVM), combined with genetic algorithms (GA). According to our data, the optimal working conditions for the removal of 98.91% Cd(II) by T. viride were found for an aqueous solution containing 26.11 mg/L Cd(II) as follows: pH 6.0, contact time of 3833 min, 8 g/L biosorbent, temperature 46.5 °C. The complete characterization of bioremoval parameters indicates that T. viride is an excellent material to treat wastewater containing low concentrations of metal.

  15. Outcome of resection of WHO Grade II meningioma and correlation of pathological and radiological predictive factors for recurrence.

    Science.gov (United States)

    Nanda, Anil; Bir, Shyamal C; Konar, Subhas; Maiti, Tanmoy; Kalakoti, Piyush; Jacobsohn, Jamie A; Guthikonda, Bharat

    2016-09-01

    This study investigated whether extent of surgical resection (Simpson and Shinshu grade) along with pathological and radiological factors influence the tumor control and recurrence-free survival (RFS) of patients with World Health Organization (WHO) grade II meningiomas. The clinical, radiological and surgical notes on the 59 patients with WHO grade II meningioma managed at our institution over 20years were retrospectively reviewed. In this study, median survival time was 41months. The overall recurrence rate in Simpson grades I and II resection was 31%. In grades III and IV, the overall recurrence rate was 73%, and this high recurrence rate in these groups was confined within 5years. In Cox regression analysis, combined data of grades (I and II)/complete resection showed a significant difference in RFS compared to grades (III and IV)/subtotal resection (p=0.0001). A similar trend of RFS (p=0.0001) was observed with the Shinshu grading system of resection. In addition, a Ki-67% marker for proliferation less than 15% (p=0.029), absence of certain radiological features including heterogeneous enhancement, cyst formation and peritumoral edema (p=0.006), and repeat surgery for recurrent meningioma was associated with better survival (p=0.014). However, radiosurgery did not have a beneficial role in the treatment of recurrence of atypical meningioma. The Simpson grading system is the primary predictor of recurrence of WHO grade II meningioma after resection. In addition, certain pathological and radiological features need to be considered as possible factors of recurrence after resection. Lastly, depending on the likely risks and surgical morbidity, repeat surgical resection should be performed for recurrent atypical meningioma.

  16. RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures.

    Science.gov (United States)

    Miao, Zhichao; Adamiak, Ryszard W; Blanchet, Marc-Frédérick; Boniecki, Michal; Bujnicki, Janusz M; Chen, Shi-Jie; Cheng, Clarence; Chojnowski, Grzegorz; Chou, Fang-Chieh; Cordero, Pablo; Cruz, José Almeida; Ferré-D'Amaré, Adrian R; Das, Rhiju; Ding, Feng; Dokholyan, Nikolay V; Dunin-Horkawicz, Stanislaw; Kladwang, Wipapat; Krokhotin, Andrey; Lach, Grzegorz; Magnus, Marcin; Major, François; Mann, Thomas H; Masquida, Benoît; Matelska, Dorota; Meyer, Mélanie; Peselis, Alla; Popenda, Mariusz; Purzycka, Katarzyna J; Serganov, Alexander; Stasiewicz, Juliusz; Szachniuk, Marta; Tandon, Arpit; Tian, Siqi; Wang, Jian; Xiao, Yi; Xu, Xiaojun; Zhang, Jinwei; Zhao, Peinan; Zok, Tomasz; Westhof, Eric

    2015-06-01

    This paper is a report of a second round of RNA-Puzzles, a collective and blind experiment in three-dimensional (3D) RNA structure prediction. Three puzzles, Puzzles 5, 6, and 10, represented sequences of three large RNA structures with limited or no homology with previously solved RNA molecules. A lariat-capping ribozyme, as well as riboswitches complexed to adenosylcobalamin and tRNA, were predicted by seven groups using RNAComposer, ModeRNA/SimRNA, Vfold, Rosetta, DMD, MC-Fold, 3dRNA, and AMBER refinement. Some groups derived models using data from state-of-the-art chemical-mapping methods (SHAPE, DMS, CMCT, and mutate-and-map). The comparisons between the predictions and the three subsequently released crystallographic structures, solved at diffraction resolutions of 2.5-3.2 Å, were carried out automatically using various sets of quality indicators. The comparisons clearly demonstrate the state of present-day de novo prediction abilities as well as the limitations of these state-of-the-art methods. All of the best prediction models have similar topologies to the native structures, which suggests that computational methods for RNA structure prediction can already provide useful structural information for biological problems. However, the prediction accuracy for non-Watson-Crick interactions, key to proper folding of RNAs, is low and some predicted models had high Clash Scores. These two difficulties point to some of the continuing bottlenecks in RNA structure prediction. All submitted models are available for download at http://ahsoka.u-strasbg.fr/rnapuzzles/.

  17. RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures

    Science.gov (United States)

    Miao, Zhichao; Adamiak, Ryszard W.; Blanchet, Marc-Frédérick; Boniecki, Michal; Bujnicki, Janusz M.; Chen, Shi-Jie; Cheng, Clarence; Chojnowski, Grzegorz; Chou, Fang-Chieh; Cordero, Pablo; Cruz, José Almeida; Ferré-D'Amaré, Adrian R.; Das, Rhiju; Ding, Feng; Dokholyan, Nikolay V.; Dunin-Horkawicz, Stanislaw; Kladwang, Wipapat; Krokhotin, Andrey; Lach, Grzegorz; Magnus, Marcin; Major, François; Mann, Thomas H.; Masquida, Benoît; Matelska, Dorota; Meyer, Mélanie; Peselis, Alla; Popenda, Mariusz; Purzycka, Katarzyna J.; Serganov, Alexander; Stasiewicz, Juliusz; Szachniuk, Marta; Tandon, Arpit; Tian, Siqi; Wang, Jian; Xiao, Yi; Xu, Xiaojun; Zhang, Jinwei; Zhao, Peinan; Zok, Tomasz; Westhof, Eric

    2015-01-01

    This paper is a report of a second round of RNA-Puzzles, a collective and blind experiment in three-dimensional (3D) RNA structure prediction. Three puzzles, Puzzles 5, 6, and 10, represented sequences of three large RNA structures with limited or no homology with previously solved RNA molecules. A lariat-capping ribozyme, as well as riboswitches complexed to adenosylcobalamin and tRNA, were predicted by seven groups using RNAComposer, ModeRNA/SimRNA, Vfold, Rosetta, DMD, MC-Fold, 3dRNA, and AMBER refinement. Some groups derived models using data from state-of-the-art chemical-mapping methods (SHAPE, DMS, CMCT, and mutate-and-map). The comparisons between the predictions and the three subsequently released crystallographic structures, solved at diffraction resolutions of 2.5–3.2 Å, were carried out automatically using various sets of quality indicators. The comparisons clearly demonstrate the state of present-day de novo prediction abilities as well as the limitations of these state-of-the-art methods. All of the best prediction models have similar topologies to the native structures, which suggests that computational methods for RNA structure prediction can already provide useful structural information for biological problems. However, the prediction accuracy for non-Watson–Crick interactions, key to proper folding of RNAs, is low and some predicted models had high Clash Scores. These two difficulties point to some of the continuing bottlenecks in RNA structure prediction. All submitted models are available for download at http://ahsoka.u-strasbg.fr/rnapuzzles/. PMID:25883046

  18. Pre-clinical grades predict clinical performance in the MBBS stage II examination at the University of the West Indies, Mona Campus.

    Science.gov (United States)

    Pepple, Dagogo J; Young, Lauriann E; Gordon-Strachan, Georgiana M; Carroll, Robert G

    2013-12-20

    In the preclinical sciences, statistically significant predictive values have been reported between the performances in one discipline and the others, supporting the hypothesis that students who perform well in one discipline were likely to perform well in the other disciplines. We therefore decided to conduct a retrospective study to investigate the predictive effects of preclinical subjects on clinical subjects from 87 students of The University of the West Indies (UWI), Mona Campus who took the MBBS Stage II examination at various times between May 2000 and May 2002. The grade in Pathology was significantly predicted by scores in Anatomy and Pharmacology; Medicine by Physiology and Pharmacology scores; Surgery by Anatomy and Social and Preventive Medicine scores; while, the Obstetrics and Gynecology grade was predicted by the Anatomy score. The results support the hypothesis that the scores in some preclinical subjects can predict the performance in specific clinical subjects, which could be interpreted to suggest that poor performance in specific preclinical disciplines could be a warning sign of future poor performance in the related clinical disciplines.

  19. Feature Selection Using Particle Swarm Optimization for Predicting the Risk of Cardiovascular Disease in Type-II Diabetic Patients

    Directory of Open Access Journals (Sweden)

    P. Radha

    2014-11-01

    Full Text Available Diabetes is the most common disease nowadays in all populations and in all age groups. A wide range of computational methods and tools for data analysis are available to predict the T2D patients with CVD risk factors. Efficient predictive modelling is required for medical researchers and practitioners to improve the prediction accuracy of the classification methods .The aim of this research was to identify significant factors influencing type 2 diabetes control with CVD risk factors, by applying particle swarm optimization feature selection system to improve prediction accuracy and knowledge discovery. Proposed system consists of four major steps such as preprocessing and dimensionality reduction of type 2 diabetes with CVD factors, Attribute Value Measurement, Feature Selection, and Hybrid Prediction Model. In proposed methods the pre-processing and dimensionality reduction of the patients records is performed by using Kullback Leiber Divergence(KLD Principal component analysis (PCA, then attribute values measurement is performed using Fast Correlation-Based Filter Solution(FCBFS, feature selection is performed by using Particle Swarm Optimization (PSO, finally hybrid prediction model which uses Improved Fuzzy C Means (IFCM clustering algorithm aimed at validating chosen class label of given data and subsequently applying Extreme Learning Machine(ELM classification algorithm to the result set.

  20. Design And Verification of Controllers for Coupled Bunch Instabilities Using Optimal Control Theory And Numerical Simulation: Predictions for PEP II

    Energy Technology Data Exchange (ETDEWEB)

    Hindi, Haitham; Prabhakar, Shyam; Fox, John D.; Linscott, Ivan; Teytelman, Dmitri; /SLAC

    2011-08-31

    We present a technique for the design and verification of efficient bunch-by-bunch controllers for damping longitudinal multibunch instabilities. The controllers attempt to optimize the use of available feedback amplifier power - one of the most expensive components of a feedback system - and define the limits of the closed loop system performance. Our design technique alternates between analytic computation of single bunch optimal controllers and verification on a multibunch numerical simulator. The simulator uses PEP-II parameters and identifies unstable coupled bunch modes, their growth rates and their damping rates with feedback. The results from the simulator are shown to be in reasonable agreement with analytical calculations based on the single bunch model. The technique is then used to evaluate the performance of a variety of controllers proposed for PEP-II.

  1. Evaluation of the use of Classical Nucleation Theory for predicting intestinal crystalline precipitation of two weakly basic BSC class II drugs.

    Science.gov (United States)

    Carlert, Sara; Lennernäs, Hans; Abrahamsson, Bertil

    2014-03-12

    The aim of this work was to evaluate an in vitro-in silico approach for prediction of small intestinal crystalline precipitation and drug absorption of two weakly basic model BCS class II drugs, AZD0865 and mebendazole. The crystallization rates were investigated in an in vitro method using simulated gastric and intestinal media, and the result was modeled by using Classical Nucleation Theory (CNT). The effect of varying in vitro parameters (initial drug concentration, rate of mixing gastric and intestinal fluid, stirring and filtration) on the interfacial tension γ, being a key parameter in CNT, was investigated. The initial drug concentration had the most significant effect on γ for both substances tested, although γ is a fundamental parameter independent of concentration according to CNT. In the subsequent in silico prediction of drug absorption, by use of a Compartmental and Transit intestinal model, an empirical approach was used where γ was allowed to vary with simulated small intestinal concentrations. The in silico predictions were compared to published human in vivo plasma drug concentration data for different doses of AZD0865 and dog intestinal drug concentrations, amount precipitated in intestine and plasma concentrations for mebendazole. The results showed that lack of significant crystallization effects on absorption in man of the model drug AZD0865 up to doses of 4 mg/kg could be predicted which was in accordance with in vivo data. Mebendazole intestinal precipitation in canines was also well described by the model, where mean predicted amount precipitated was 136% (range 111-164%) of measured solid amount, and mean predicted intestinal concentration was 94% (range 59-147%) of measured concentration. In conclusion, the in vitro-in silico approach can be used for predictions of absorption effects of crystallization, but the model could benefit from further development work on the theoretical crystallization model and in vitro experimental design.

  2. Serum estradiol levels predict survival and acute kidney injury in patients with septic shock--a prospective study.

    Directory of Open Access Journals (Sweden)

    Jia-Yih Feng

    Full Text Available Sex hormones have diverse immunomodulatory effects that may be involved in the pathogenesis of sepsis. However, the roles of serum sex hormones in predicting outcomes and the severity of organ dysfunction, especially acute kidney injury (AKI, in septic shock patients remains controversial. We prospectively enrolled 107 clinically diagnosed pneumonia-related septic shock patients and serum sex hormone levels were measured on the day of shock onset. The aim of the present study was to investigate the predictive values of serum sex hormones levels for 28-day mortality and organs dysfunction, especially AKI. Compared with survivors, serum levels of progesterone (p40 pg/mL (p = 0.047 and APACHE II score ≥25 (p = 40 pg/mL was also an independent predictor of concomitant AKI (p = 0.002 and correlated well with severity of renal dysfunction using RIFLE classification. Elevated serum estradiol levels also predicted the development of new AKI within 28 days of shock onset (p = 0.013. In conclusion, serum estradiol levels appear to have value in predicting 28-day mortality in septic shock patients. Increased serum estradiol levels are associated with higher severity of concomitant AKI and predict development of new AKI.

  3. Major histocompatibility complex class II compatibility, but not class I, predicts mate choice in a bird with highly developed olfaction.

    Science.gov (United States)

    Strandh, Maria; Westerdahl, Helena; Pontarp, Mikael; Canbäck, Björn; Dubois, Marie-Pierre; Miquel, Christian; Taberlet, Pierre; Bonadonna, Francesco

    2012-11-01

    Mate choice for major histocompatibility complex (MHC) compatibility has been found in several taxa, although rarely in birds. MHC is a crucial component in adaptive immunity and by choosing an MHC-dissimilar partner, heterozygosity and potentially broad pathogen resistance is maximized in the offspring. The MHC genotype influences odour cues and preferences in mammals and fish and hence olfactory-based mate choice can occur. We tested whether blue petrels, Halobaena caerulea, choose partners based on MHC compatibility. This bird is long-lived, monogamous and can discriminate between individual odours using olfaction, which makes it exceptionally well suited for this analysis. We screened MHC class I and II B alleles in blue petrels using 454-pyrosequencing and quantified the phylogenetic, functional and allele-sharing similarity between individuals. Partners were functionally more dissimilar at the MHC class II B loci than expected from random mating (p = 0.033), whereas there was no such difference at the MHC class I loci. Phylogenetic and non-sequence-based MHC allele-sharing measures detected no MHC dissimilarity between partners for either MHC class I or II B. Our study provides evidence of mate choice for MHC compatibility in a bird with a high dependency on odour cues, suggesting that MHC odour-mediated mate choice occurs in birds.

  4. Statement of Hubert Velarde, Jicarilla Apache Tribe to United States Commission on Civil Rights at Albuquerque Convention Center (Albuquerque, New Mexico, November 14, 1972).

    Science.gov (United States)

    Velarde, Hubert

    The statement by the President of the Jicarilla Apache Tribe emphasizes reservation problems that need to be examined. Presented at a 1972 Civil Rights Commission hearing on Indian Concerns, Velarde's statement listed employment, education, the administration of justice, water rights, and medical services as areas for investigation. (KM)

  5. Charters, Constitutions and By-Laws of the Indian Tribes of North America; Part III: The Southwest (Apache--Mohave). Occasional Publications in Anthropology Ethnology Series No. 4.

    Science.gov (United States)

    Fay, George E., Comp.

    The Museum of Anthropology of the University of Northern Colorado (formerly known as Colorado State College) has assembled a large number of Indian tribal charters, constitutions, and by-laws to be reproduced as a series of publications. Included in this volume are the amended charter and constitution of the Jicarilla Apache Tribe, Dulce, New…

  6. Formal Education on the White Mountain Apache Reservation; Report of a Self-Study Conference. The National Study of American Indian Education, Series I, No. 25, Final Report.

    Science.gov (United States)

    Anderson, Ned; Chilcott, John H.

    In one phase of the National Study of American Indian Education, local Indian communities were encouraged to conduct their own self-studies of American Indian education. In keeping with this, a conference was held to determine the attitudinal responses of White Mountain Apaches (aged 20-48) to the following general topics concerning Indian…

  7. Specification of variables predictive of victories in the sport of boxing: II. Further characterization of previous success.

    Science.gov (United States)

    Warnick, Jason E; Warnick, Kyla

    2009-02-01

    Previous success, i.e., performance in the preceding bout and total number of wins and losses, was predictive of victory. Clarification of this effect was sought in examining whether the prior performance against a particular opponent or in a common location would be predictive of a victory in a bout against that opponent or in that locale. The career records of 739 male professional boxers who participated in contests held in the USA in November 2007 were collected from the BoxRec online database. Chi-squared tests and logistic regression analyses indicated that performance in the preceding bout, prior performance against the same opponent, and prior performance in a particular location were predictive of the outcome in a current bout.

  8. Cracking behavior of tungsten armor under ELM-like thermal shockloads II: A revised prediction for crack appearance map

    Directory of Open Access Journals (Sweden)

    Muyuan Li

    2016-12-01

    Full Text Available In this work, the surface cracking features of tungsten armor under thermal shock loads by edge-localized mode (ELM were investigated by means of computational fracture mechanics analysis. For the simulation it was assumed that a small crack was initiated at low temperature after the shut-off of thermal load in contrast to the previous studies where the presence of a crack before thermal loading was assumed. The threshold power density for surface cracking was predicted to range between 0.3 and 0.6GW/m2 while the threshold of base temperature lay between 200 and 400°C. The theoretically predicted damage map agreed well with the experimental data from electron beam irradiation tests. The current simulation model turned out to match better to the real experimental observation than the previous predictions where the threshold base temperature lies roughly between 400 and 600°C.

  9. High-Precision Lunar Ranging and Gravitational Parameter Estimation With the Apache Point Observatory Lunar Laser-ranging Operation

    Science.gov (United States)

    Johnson, Nathan H.

    This dissertation is concerned with several problems of instrumentation and data analysis encountered by the Apache Point Observatory Lunar Laser-ranging Operation. Chapter 2 considers crosstalk between elements of a single-photon avalanche photodiode detector. Experimental and analytic methods were developed to determine crosstalk rates, and empirical findings are presented. Chapter 3 details electronics developments that have improved the quality of data collected by detectors of the same type. Chapter 4 explores the challenges of estimating gravitational parameters on the basis of ranging data collected by this and other experiments and presents resampling techniques for the derivation of standard errors for estimates of such parameters determined by the Planetary Ephemeris Program (PEP), a solar-system model and data-fitting code. Possible directions for future work are discussed in Chapter 5. A manual of instructions for working with PEP is presented as an appendix.

  10. Linux中基于Apache个人网站的配置%Configuration of Personal Web Site Based on Apache for Linux

    Institute of Scientific and Technical Information of China (English)

    弋改珍

    2012-01-01

    WWW是Internet上最热门的服务之一,已经成为人们在网络上查找、浏览信息的重要手段.根据WWW的工作原理,阐述了 Linux中基于Apache软件配置个人网站的步骤,总结了配置过程中出现的问题以及解决方案,并使用html文档进行了测试.%WWW is one of the hottest services on Internet. It has become the important method of the finding, browsing the information. According to the principle of www, the paper has stated the configuration steps of the personal web site based on Apache for Linux, The appearance problem and solution are concluded. And last, the tests are run using html document.

  11. Assessing the impact of land use change on hydrology by ensemble modelling (LUCHEM) II: Ensemble combinations and predictions

    Science.gov (United States)

    Viney, N.R.; Bormann, H.; Breuer, L.; Bronstert, A.; Croke, B.F.W.; Frede, H.; Graff, T.; Hubrechts, L.; Huisman, J.A.; Jakeman, A.J.; Kite, G.W.; Lanini, J.; Leavesley, G.; Lettenmaier, D.P.; Lindstrom, G.; Seibert, J.; Sivapalan, M.; Willems, P.

    2009-01-01

    This paper reports on a project to compare predictions from a range of catchment models applied to a mesoscale river basin in central Germany and to assess various ensemble predictions of catchment streamflow. The models encompass a large range in inherent complexity and input requirements. In approximate order of decreasing complexity, they are DHSVM, MIKE-SHE, TOPLATS, WASIM-ETH, SWAT, PRMS, SLURP, HBV, LASCAM and IHACRES. The models are calibrated twice using different sets of input data. The two predictions from each model are then combined by simple averaging to produce a single-model ensemble. The 10 resulting single-model ensembles are combined in various ways to produce multi-model ensemble predictions. Both the single-model ensembles and the multi-model ensembles are shown to give predictions that are generally superior to those of their respective constituent models, both during a 7-year calibration period and a 9-year validation period. This occurs despite a considerable disparity in performance of the individual models. Even the weakest of models is shown to contribute useful information to the ensembles they are part of. The best model combination methods are a trimmed mean (constructed using the central four or six predictions each day) and a weighted mean ensemble (with weights calculated from calibration performance) that places relatively large weights on the better performing models. Conditional ensembles, in which separate model weights are used in different system states (e.g. summer and winter, high and low flows) generally yield little improvement over the weighted mean ensemble. However a conditional ensemble that discriminates between rising and receding flows shows moderate improvement. An analysis of ensemble predictions shows that the best ensembles are not necessarily those containing the best individual models. Conversely, it appears that some models that predict well individually do not necessarily combine well with other models in

  12. Demonstration of the Military Ecological Risk Assessment Framework (MERAF): Apache Longbow - Hell Missile Test at Yuma Proving Ground

    Energy Technology Data Exchange (ETDEWEB)

    Efroymson, R.A.

    2002-05-09

    This ecological risk assessment for a testing program at Yuma Proving Ground, Arizona, is a demonstration of the Military Ecological Risk Assessment Framework (MERAF; Suter et al. 2001). The demonstration is intended to illustrate how risk assessment guidance concerning-generic military training and testing activities and guidance concerning a specific type of activity (e.g., low-altitude aircraft overflights) may be implemented at a military installation. MERAF was developed with funding from the Strategic Research and Development Program (SERDP) of the Department of Defense. Novel aspects of MERAF include: (1) the assessment of risks from physical stressors using an ecological risk assessment framework, (2) the consideration of contingent or indirect effects of stressors (e.g., population-level effects that are derived from habitat or hydrological changes), (3) the integration of risks associated with different component activities or stressors, (4) the emphasis on quantitative risk estimates and estimates of uncertainty, and (5) the modularity of design, permitting components of the framework to be used in various military risk assessments that include similar activities. The particular subject of this report is the assessment of ecological risks associated with a testing program at Cibola Range of Yuma Proving Ground, Arizona. The program involves an Apache Longbow helicopter firing Hellfire missiles at moving targets, i.e., M60-A1 tanks. Thus, the three component activities of the Apache-Hellfire test were: (1) helicopter overflight, (2) missile firing, and (3) tracked vehicle movement. The demonstration was limited, to two ecological endpoint entities (i.e., potentially susceptible and valued populations or communities): woody desert wash communities and mule deer populations. The core assessment area is composed of about 126 km{sup 2} between the Chocolate and Middle Mountains. The core time of the program is a three-week period, including fourteen days of

  13. Can early computed tomography angiography after endovascular aortic aneurysm repair predict the need for reintervention in patients with type II endoleak?

    Science.gov (United States)

    Dudeck, O; Schnapauff, D; Herzog, L; Löwenthal, D; Bulla, K; Bulla, B; Halloul, Z; Meyer, F; Pech, M; Gebauer, B; Ricke, J

    2015-02-01

    This study was designed to identify parameters on CT angiography (CTA) of type II endoleaks following endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA), which can be used to predict the subsequent need for reinterventions. We retrospectively identified 62 patients with type II endoleak who underwent early CTA in mean 3.7 ± 1.9 days after EVAR. On the basis of follow-up examinations (mean follow-up period 911 days; range, 373-1,987 days), patients were stratified into two groups: those who did (n = 18) and those who did not (n = 44) require reintervention. CTA characteristics, such as AAA, endoleak, as well as nidus dimensions, patency of the inferior mesenteric artery, number of aortic branch vessels, and the pattern of endoleak appearance, were recorded and correlated with the clinical outcome. Univariate and receiver operating characteristic curve regression analyses revealed significant differences between the two groups for the endoleak volume (surveillance group: 1391.6 ± 1427.9 mm(3); reintervention group: 3227.7 ± 2693.8 mm(3); cutoff value of 2,386 mm(3); p = 0.002), the endoleak diameter (13.6 ± 4.3 mm compared with 25.9 ± 9.6 mm; cutoff value of 19 mm; p < 0.0001), the number of aortic branch vessels (2.9 ± 1.2 compared with 4.2 ± 1.4 vessels; p = 0.001), as well as a "complex type" endoleak pattern (13.6 %, n = 6 compared with 44.4 %, n = 8; p = 0.02). Early CTA can predict the future need for reintervention in patients with type II endoleak. Therefore, treatment decision should be based not only on aneurysm enlargement alone but also on other imaging characteristics.

  14. Phobic anxiety in 11 nations : part II. Hofstede's dimensions of national cultures predict national-level variations

    NARCIS (Netherlands)

    Arrindell, WA; Eisemann, M; Oei, TPS; Caballo, VE; Sanavio, E; Sica, C; Bages, N; Feldman, L; Torres, B; Iwawaki, S; Hatzichristou, C; Castro, J; Canalda, G; Furnham, A; van der Ende, J

    Hofstede's dimensions of national cultures termed Masculinity-Femininity (MAS) and Uncertainty Avoidance (UAI) (Hofstede, 2001) are proposed to be of relevance for understanding national-level differences in self-assessed fears. The potential predictive role of national MAS was based on the

  15. Predictive modeling of infrared radiative heating in tomato dry-peeling process: Part II. Model validation and sensitivity analysis

    Science.gov (United States)

    A predictive mathematical model was developed to simulate heat transfer in a tomato undergoing double sided infrared (IR) heating in a dry-peeling process. The aims of this study were to validate the developed model using experimental data and to investigate different engineering parameters that mos...

  16. Phobic anxiety in 11 nations : part II. Hofstede's dimensions of national cultures predict national-level variations

    NARCIS (Netherlands)

    Arrindell, WA; Eisemann, M; Oei, TPS; Caballo, VE; Sanavio, E; Sica, C; Bages, N; Feldman, L; Torres, B; Iwawaki, S; Hatzichristou, C; Castro, J; Canalda, G; Furnham, A; van der Ende, J

    2004-01-01

    Hofstede's dimensions of national cultures termed Masculinity-Femininity (MAS) and Uncertainty Avoidance (UAI) (Hofstede, 2001) are proposed to be of relevance for understanding national-level differences in self-assessed fears. The potential predictive role of national MAS was based on the classica

  17. Score for neonatal acute physiology-II and neonatal pain predict corticospinal tract development in premature newborns.

    Science.gov (United States)

    Zwicker, Jill G; Grunau, Ruth E; Adams, Elysia; Chau, Vann; Brant, Rollin; Poskitt, Kenneth J; Synnes, Anne; Miller, Steven P

    2013-02-01

    Premature infants are at risk for adverse motor outcomes, including cerebral palsy and developmental coordination disorder. The purpose of this study was to examine the relationship of antenatal, perinatal, and postnatal risk factors for abnormal development of the corticospinal tract, the major voluntary motor pathway, during the neonatal period. In a prospective cohort study, 126 premature neonates (24-32 weeks' gestational age) underwent serial brain imaging near birth and at term-equivalent age. With diffusion tensor tractography, mean diffusivity and fractional anisotropy of the corticospinal tract were measured to reflect microstructural development. Generalized estimating equation models examined associations of risk factors on corticospinal tract development. The perinatal risk factor of greater early illness severity (as measured by the Score for Neonatal Acute Physiology-II [SNAP-II]) was associated with a slower rise in fractional anisotropy of the corticospinal tract (P = 0.02), even after correcting for gestational age at birth and postnatal risk factors (P = 0.009). Consistent with previous findings, neonatal pain adjusted for morphine and postnatal infection were also associated with a slower rise in fractional anisotropy of the corticospinal tract (P = 0.03 and 0.02, respectively). Lessening illness severity in the first hours of life might offer potential to improve motor pathway development in premature newborns.

  18. Predicting Individualized Postoperative Survival for Stage II/III Colon Cancer Using a Mobile Application Derived from the National Cancer Data Base

    Science.gov (United States)

    Gabriel, Emmanuel; Attwood, Kristopher; Thirunavukarasu, Pragatheeshwar; Al-Sukhni, Eisar; Boland, Patrick; Nurkin, Steven

    2017-01-01

    BACKGROUND Prediction calculators estimate postoperative survival and assist the decision-making process for adjuvant treatment. The objective of this study was to create a postoperative overall survival (OS) calculator for patients with stage II/III colon cancer. Factors that influence OS, including comorbidity and postoperative variables, were included. STUDY DESIGN The National Cancer Data Base was queried for patients with stage II/III colon cancer, diagnosed between 2004 and 2006, who had surgical resection. Patients were randomly divided to a testing (nt) cohort comprising 80% of the dataset and a validation (nv) cohort comprising 20%. Multivariable Cox proportional hazards regression of nt was performed to identify factors associated with 5-year OS. These were used to build a prediction model. The performance was assessed using the nv cohort and translated into mobile software. RESULTS A total of 129,040 patients had surgery. After exclusion of patients with carcinoma in situ, non-adenocarcinoma histology, more than 1 malignancy, stage I or IV disease, or missing data, 34,176 patients were used in the development of the calculator. Independent predictors of OS included patient-specific characteristics, pathologic factors, and treatment options, including type of surgery and adjuvant therapy. Length of postoperative stay and unplanned readmission rates were also incorporated as surrogates for postoperative complications (1-day increase in postoperative stay, hazard ratio [HR] 1.019, 95% CI 1.018 to 1.021, p cancer. This prediction model uses nationwide data, culminating in a highly comprehensive, clinically useful tool. PMID:26922599

  19. Comparing the suitability of autodock, gold and glide for the docking and predicting the possible targets of Ru(II)-based complexes as anticancer agents.

    Science.gov (United States)

    Adeniyi, Adebayo A; Ajibade, Peter A

    2013-03-25

    In cancer chemotherapy, metal-based complexes have been recognized as the most promising means of inhibiting cancer growth due to the successful application of cis-platin and its derivatives above many of the existing organic anticancer agents. The limitations in their rational design can be traced to the complexity of the mechanism of their operations, lack of proper knowledge of their targets and lack of force fields in docking packages to appropriately define the metal centre of the organometallic complexes. In this paper, some of the promising anticancer complexes of Ru(II) such as the rapta-based complexes formulated as [Ru(η6-p-cymene)L2(pta)] and those with unusual ligands are considered. CatB and kinases which have been experimentally confirmed as possible targets of the complexes are also predicted by the three methods as one of the most targeted receptors while TopII and HDAC7 are predicted by two and one of the methods as best targets. The interesting features of the binding of the complexes show that some of the complexes preferentially target specific macromolecules than the others, which is an indication of their specificity and possibility of their therapeutic combination without severe side effects that may come from competition for the same target. Also, introduction of unusual ligands is found to significantly improve the activities of most of the complexes studied. Strong correlations are observed for the predicted binding sites and the orientation of the complexes within the binding site by the three methods of docking. However there are disparities in the ranking of the complexes by the three method of docking, especially that of Glide.

  20. Comparing the Suitability of Autodock, Gold and Glide for the Docking and Predicting the Possible Targets of Ru(II-Based Complexes as Anticancer Agents

    Directory of Open Access Journals (Sweden)

    Adebayo A. Adeniyi

    2013-03-01

    Full Text Available In cancer chemotherapy, metal-based complexes have been recognized as the most promising means of inhibiting cancer growth due to the successful application of cis-platin and its derivatives above many of the existing organic anticancer agents. The limitations in their rational design can be traced to the complexity of the mechanism of their operations, lack of proper knowledge of their targets and lack of force fields in docking packages to appropriately define the metal centre of the organometallic complexes. In this paper, some of the promising anticancer complexes of Ru(II such as the rapta-based complexes formulated as [Ru(η6-p-cymeneL2(pta] and those with unusual ligands are considered. CatB and kinases which have been experimentally confirmed as possible targets of the complexes are also predicted by the three methods as one of the most targeted receptors while TopII and HDAC7 are predicted by two and one of the methods as best targets. The interesting features of the binding of the complexes show that some of the complexes preferentially target specific macromolecules than the others, which is an indication of their specificity and possibility of their therapeutic combination without severe side effects that may come from competition for the same target. Also, introduction of unusual ligands is found to significantly improve the activities of most of the complexes studied. Strong correlations are observed for the predicted binding sites and the orientation of the complexes within the binding site by the three methods of docking. However there are disparities in the ranking of the complexes by the three method of docking, especially that of Glide.

  1. Developing predictive approaches to characterize adaptive responses of the reproductive endocrine axis to aromatase inhibition: II. Computational modeling.

    Science.gov (United States)

    Breen, Miyuki; Villeneuve, Daniel L; Ankley, Gerald T; Bencic, David C; Breen, Michael S; Watanabe, Karen H; Lloyd, Alun L; Conolly, Rory B

    2013-06-01

    Endocrine-disrupting chemicals can affect reproduction and development in humans and wildlife. We developed a computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minnows to predict dose-response and time-course (DRTC) behaviors for endocrine effects of the aromatase inhibitor, fadrozole (FAD). The model describes adaptive responses to endocrine stress involving regulated secretion of a generic gonadotropin (LH/FSH) from the hypothalamic-pituitary complex. For model development, we used plasma 17β-estradiol (E2) concentrations and ovarian cytochrome P450 (CYP) 19A aromatase mRNA data from two time-course experiments, each of which included both an exposure and a depuration phase, and plasma E2 data from a third 4-day study. Model parameters were estimated using E2 concentrations for 0, 0.5, and 3 µg/l FAD exposure concentrations, and good fits to these data were obtained. The model accurately predicted CYP19A mRNA fold changes for controls and three FAD doses (0, 0.5, and 3 µg/l) and plasma E2 dose response from the 4-day study. Comparing the model-predicted DRTC with experimental data provided insight into how the feedback control mechanisms in the HPG axis mediate these changes: specifically, adaptive changes in plasma E2 levels occurring during exposure and "overshoot" occurring postexposure. This study demonstrates the value of mechanistic modeling to examine and predict dynamic behaviors in perturbed systems. As this work progresses, we will obtain a refined understanding of how adaptive responses within the vertebrate HPG axis affect DRTC behaviors for aromatase inhibitors and other types of endocrine-active chemicals and apply that knowledge in support of risk assessments.

  2. Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study.

    Science.gov (United States)

    Erdem, Hakan; Ozturk-Engin, Derya; Tireli, Hulya; Kilicoglu, Gamze; Defres, Sylviane; Gulsun, Serda; Sengoz, Gonul; Crisan, Alexandru; Johansen, Isik Somuncu; Inan, Asuman; Nechifor, Mihai; Al-Mahdawi, Akram; Civljak, Rok; Ozguler, Muge; Savic, Branislava; Ceran, Nurgul; Cacopardo, Bruno; Inal, Ayse Seza; Namiduru, Mustafa; Dayan, Saim; Kayabas, Uner; Parlak, Emine; Khalifa, Ahmad; Kursun, Ebru; Sipahi, Oguz Resat; Yemisen, Mucahit; Akbulut, Ayhan; Bitirgen, Mehmet; Popovic, Natasa; Kandemir, Bahar; Luca, Catalina; Parlak, Mehmet; Stahl, Jean Paul; Pehlivanoglu, Filiz; Simeon, Soline; Ulu-Kilic, Aysegul; Yasar, Kadriye; Yilmaz, Gulden; Yilmaz, Emel; Beovic, Bojana; Catroux, Melanie; Lakatos, Botond; Sunbul, Mustafa; Oncul, Oral; Alabay, Selma; Sahin-Horasan, Elif; Kose, Sukran; Shehata, Ghaydaa; Andre, Katell; Dragovac, Gorana; Gul, Hanefi Cem; Karakas, Ahmet; Chadapaud, Stéphane; Hansmann, Yves; Harxhi, Arjan; Kirova, Valerija; Masse-Chabredier, Isabelle; Oncu, Serkan; Sener, Alper; Tekin, Recep; Elaldi, Nazif; Deveci, Ozcan; Ozkaya, Hacer Deniz; Karabay, Oguz; Senbayrak, Seniha; Agalar, Canan; Vahaboglu, Haluk

    2015-01-01

    Predicting unfavorable outcome is of paramount importance in clinical decision making. Accordingly, we designed this multinational study, which provided the largest case series of tuberculous meningitis (TBM). 43 centers from 14 countries (Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria, Turkey) submitted data of microbiologically confirmed TBM patients hospitalized between 2000 and 2012. Unfavorable outcome was defined as survival with significant sequela or death. In developing our index, binary logistic regression models were constructed via 200 replicates of database by bootstrap resampling methodology. The final model was built according to the selection frequencies of variables. The severity scale included variables with arbitrary scores proportional to predictive powers of terms in the final model. The final model was internally validated by bootstrap resampling. A total of 507 patients' data were submitted among which 165 had unfavorable outcome. Eighty-six patients died while 119 had different neurological sequelae in 79 (16%) patients. The full model included 13 variables. Age, nausea, vomiting, altered consciousness, hydrocephalus, vasculitis, immunosuppression, diabetes mellitus and neurological deficit remained in the final model. Scores 1-3 were assigned to the variables in the severity scale, which included scores of 1-6. The distribution of mortality for the scores 1-6 was 3.4, 8.2, 20.6, 31, 30 and 40.1%, respectively. Altered consciousness, diabetes mellitus, immunosuppression, neurological deficits, hydrocephalus, and vasculitis predicted the unfavorable outcome in the scoring and the cumulative score provided a linear estimation of prognosis.

  3. Predicting sex offender recidivism. I. Correcting for item overselection and accuracy overestimation in scale development. II. Sampling error-induced attenuation of predictive validity over base rate information.

    Science.gov (United States)

    Vrieze, Scott I; Grove, William M

    2008-06-01

    The authors demonstrate a statistical bootstrapping method for obtaining unbiased item selection and predictive validity estimates from a scale development sample, using data (N = 256) of Epperson et al. [2003 Minnesota Sex Offender Screening Tool-Revised (MnSOST-R) technical paper: Development, validation, and recommended risk level cut scores. Retrieved November 18, 2006 from Iowa State University Department of Psychology web site: http://www.psychology.iastate.edu/ approximately dle/mnsost_download.htm] from which the Minnesota Sex Offender Screening Tool-Revised (MnSOST-R) was developed. Validity (area under receiver operating characteristic curve) reported by Epperson et al. was .77 with 16 items selected. The present analysis yielded an asymptotically unbiased estimator AUC = .58. The present article also focused on the degree to which sampling error renders estimated cutting scores (appropriate to local [varying] recidivism base rates) nonoptimal, so that the long-run performance (measured by correct fraction, the total proportion of correct classifications) of these estimated cutting scores is poor, when they are applied to their parent populations (having assumed values for AUC and recidivism rate). This was investigated by Monte Carlo simulation over a range of AUC and recidivism rate values. Results indicate that, except for the AUC values higher than have ever been cross-validated, in combination with recidivism base rates severalfold higher than the literature average [Hanson and Morton-Bourgon, 2004, Predictors of sexual recidivism: An updated meta-analysis. (User report 2004-02.). Ottawa: Public Safety and Emergency Preparedness Canada], the user of an instrument similar in performance to the MnSOST-R cannot expect to achieve correct fraction performance notably in excess of what is achievable from knowing the population recidivism rate alone. The authors discuss the legal implications of their findings for procedural and substantive due process in

  4. Chemical Feature-Based Molecular Modeling of Urotensin-II Receptor Antagonists: Generation of Predictive Pharmacophore Model for Early Drug Discovery

    Directory of Open Access Journals (Sweden)

    Anubhuti Pandey

    2014-01-01

    Full Text Available For a series of 35 piperazino-phthalimide and piperazino-isoindolinone based urotensin-II receptor (UT antagonists, a thoroughly validated 3D pharmacophore model has been developed, consisting of four chemical features: one hydrogen bond acceptor lipid (HBA_L, one hydrophobe (HY, and two ring aromatic (RA. Multiple validation techniques like CatScramble, test set prediction, and mapping analysis of advanced known antagonists have been employed to check the predictive power and robustness of the developed model. The results demonstrate that the best model, Hypo 1, shows a correlation (r of 0.902, a root mean square deviation (RMSD of 0.886, and the cost difference of 39.69 bits. The model obtained is highly predictive with good correlation values for both internal (r2=0.707 as well as external (r2=0.614 test set compounds. Moreover, the pharmacophore model has been used as a 3D query for virtual screening which served to detect prospective new lead compounds which can be further optimized as UT antagonists with potential for treatment of cardiovascular diseases.

  5. Five-factor model personality domains in the prediction of Axis II personality disorders: an exploratory study in late adulthood women non-clinical sample.

    Science.gov (United States)

    Henriques-Calado, Joana; Duarte-Silva, Maria Eugénia; Junqueira, Diana; Sacoto, Carlota; Keong, Ana Marta

    2014-05-01

    Relationships between Axis II personality disorders (DSM-IV) and the five-factor model were explored in a non-clinical sample of late adulthood women. The sample consists of 90 women (M = 72.29 years of age, standard deviation = 7.10), who were administered with two measures, the NEO-FFI and the Personality Diagnostic Questionnaire-4+. Some personality disorders scales such as paranoid, schizotypal, borderline and dependent demonstrate a differentiated pattern of five-factor model domain predictors. Low agreeableness predicted schizoid, narcissistic and antisocial; histrionic, obsessive-compulsive and negativistic were predicted by high neuroticism and low agreeableness; high neuroticism and low extraversion, in turn, predicted dependent and depressive scales. Also, two clusters of personality disorders are identified, one associated with low agreeableness and another with low agreeableness and high neuroticism. This study suggest that some traits become maladaptive personality traits, and correspond more closely to psychopathology, when they become opposite to what would be expected in line with studies in normal late adulthood development.

  6. Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

    Science.gov (United States)

    Abe, Koji; Bridges, Arlene S.; Brouwer, Kim L. R.

    2009-01-01

    Previous reports have indicated that in vitro biliary clearance (Clbiliary) determined in sandwich-cultured hepatocytes correlates well with in vivo Clbiliary for limited sets of compounds. The purpose of this study was 1) to determine the in vitro Clbiliary in sandwich-cultured human hepatocytes of angiotensin II receptor blockers and HMG-CoA reductase inhibitors that undergo limited metabolism and 2) to compare the predicted Clbiliary values with estimated in vivo hepatic clearance data in humans. The average biliary excretion index and in vitro intrinsic Clbiliary values of olmesartan, valsartan, pravastatin, rosuvastatin, and pitavastatin in sandwich-cultured human hepatocytes were 35, 23, 31, 25, and 16%, respectively, and 0.943, 1.20, 0.484, 3.39, and 5.48 ml/min/kg, respectively. Clbiliary values predicted from sandwich-cultured human hepatocytes correlated with estimated in vivo hepatic clearance values based on published data (no in vivo data in humans was available for pitavastatin), and the rank order was also consistent. In conclusion, in vitro Clbiliary determined in sandwich-cultured human hepatocytes can be used to predict in vivo Clbiliary of compounds in humans. PMID:19074974

  7. A stochastic damage model for the rupture prediction of a multi-phase solid. I - Parametric studies. II - Statistical approach

    Science.gov (United States)

    Lua, Yuan J.; Liu, Wing K.; Belytschko, Ted

    1992-01-01

    A stochastic damage model for predicting the rupture of a brittle multiphase material is developed, based on the microcrack-macrocrack interaction. The model, which incorporates uncertainties in locations, orientations, and numbers of microcracks, characterizes damage by microcracking and fracture by macrocracking. A parametric study is carried out to investigate the change of the stress intensity at the macrocrack tip by the configuration of microcracks. The inherent statistical distribution of the fracture toughness arising from the intrinsic random nature of microcracks is explored using a statistical approach. For this purpose, a computer simulation model is introduced, which incorporates a statistical characterization of geometrical parameters of a random microcrack array.

  8. An Assessment of CFD/CSD Prediction State-of-the-Art by Using the HART II International Workshop Data

    Science.gov (United States)

    Smith, Marilyn J.; Lim, Joon W.; vanderWall, Berend G.; Baeder, James D.; Biedron, Robert T.; Boyd, D. Douglas, Jr.; Jayaraman, Buvana; Jung, Sung N.; Min, Byung-Young

    2012-01-01

    Over the past decade, there have been significant advancements in the accuracy of rotor aeroelastic simulations with the application of computational fluid dynamics methods coupled with computational structural dynamics codes (CFD/CSD). The HART II International Workshop database, which includes descent operating conditions with strong blade-vortex interactions (BVI), provides a unique opportunity to assess the ability of CFD/CSD to capture these physics. In addition to a baseline case with BVI, two additional cases with 3/rev higher harmonic blade root pitch control (HHC) are available for comparison. The collaboration during the workshop permits assessment of structured, unstructured, and hybrid overset CFD/CSD methods from across the globe on the dynamics, aerodynamics, and wake structure. Evaluation of the plethora of CFD/CSD methods indicate that the most important numerical variables associated with most accurately capturing BVI are a two-equation or detached eddy simulation (DES)-based turbulence model and a sufficiently small time step. An appropriate trade-off between grid fidelity and spatial accuracy schemes also appears to be pertinent for capturing BVI on the advancing rotor disk. Overall, the CFD/CSD methods generally fall within the same accuracy; cost-effective hybrid Navier-Stokes/Lagrangian wake methods provide accuracies within 50% the full CFD/CSD methods for most parameters of interest, except for those highly influenced by torsion. The importance of modeling the fuselage is observed, and other computational requirements are discussed.

  9. Micromechanics analysis of space simulated thermal stresses in composites. I - Theory and unidirectional laminates. II - Multidirectional laminates and failure predictions

    Science.gov (United States)

    Bowles, David E.; Griffin, O. H., Jr.

    1991-01-01

    A micromechanics analysis is used to study the effects of constituent properties on thermally induced stresses in continuous fiber reinforced composites. A finite element formulation is described, and results are presented for unidirectional carbon/epoxy laminates. It is shown that significant stresses develop in composites exposed to thermal excursions typical of spacecraft operating environments and that the fiber thermoelastic properties have a minimal effect on the magnitude of these stresses. The finite element micromechanics analysis is then extended to the study of multidirectional laminates using a simple global/local formulation. Damage initiation predictions are compared with experimental data, and factors controlling the initiation of damage are identified. Ways of improving the durability of composites are discussed.

  10. Lunar Outgassing, Transient Phenomena & the Return to the Moon, II: Predictions and Tests for Outgassing/Regolith Interactions

    CERN Document Server

    Crotts, Arlin P S

    2009-01-01

    We follow Paper I with predictions of how gas leaking through the lunar surface could influence the regolith, as might be observed via optical Transient Lunar Phenomena (TLPs) and related effects. We touch on several processes, but concentrate on low and high flow rate extremes, perhaps the most likely. We model explosive outgassing for the smallest gas overpressure at the regolith base that releases the regolith plug above it. This disturbance's timescale and affected area are consistent with observed TLPs; we also discuss other effects. For slow flow, escape through the regolith is prolonged by low diffusivity. Water, found recently in deep magma samples, is unique among candidate volatiles, capable of freezing between the regolith base and surface, especially near the lunar poles. For major outgassing sites, we consider the possible accumulation of water ice. Over geological time ice accumulation can evolve downward through the regolith. Depending on gases additional to water, regolith diffusivity might be...

  11. Use of a semiquantitative procalcitonin kit for evaluating severity and predicting mortality in patients with sepsis

    Directory of Open Access Journals (Sweden)

    Kenzaka T

    2012-05-01

    Full Text Available Tsuneaki Kenzaka,1 Masanobu Okayama,2 Shigehiro Kuroki,1 Miho Fukui,3 Shinsuke Yahata,3 Hiroki Hayashi,3 Akihito Kitao,3 Eiji Kajii,2 Masayoshi Hashimoto41Division of General Medicine, 2Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University School of Medicine, Shimotsuke; 3Department of General Medicine, Toyooka Public Hospital, Toyooka; 4Department of Family and Community Medicine, Kobe University Graduate School of Medicine, Kobe, JapanBackground: The aim of this study was to evaluate the clinical usefulness of a semiquantitative procalcitonin kit for assessing severity of sepsis and early determination of mortality in affected patients.Methods: This was a prospective, observational study including 206 septic patients enrolled between June 2008 and August 2009. Disseminated intravascular coagulation (DIC, Sequential Organ Failure Assessment (SOFA, Acute Physiology and Chronic Health Evaluation (APACHE II scores were measured, along with semiquantitative procalcitonin concentrations. Patients were divided into three groups based on their semiquantitative procalcitonin concentrations (group A, <2 ng/mL; group B ≥ 2 ng/mL < 10 ng/mL; group C ≥ 10 ng/mL.Results: A significant difference in DIC, SOFA, and APACHE II scores was found between group A and group C and between group B and group C (P < 0.01. Patients with severe sepsis and septic shock had significantly higher procalcitonin concentrations than did patients with less severe disease. The rate of patients with septic shock with high procalcitonin concentrations showed an upward trend. There was a significant (P < 0.01 difference between the three groups with regard to numbers of patients and rates of severe sepsis, septic shock, DIC, and mortality.Conclusion: Semiquantitative procalcitonin concentration testing can be helpful for early assessment of disease severity in patients with sepsis. Furthermore, it may also help in predicting early

  12. Identification of PPARgamma partial agonists of natural origin (II: in silico prediction in natural extracts with known antidiabetic activity.

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    Laura Guasch

    Full Text Available BACKGROUND: Natural extracts have played an important role in the prevention and treatment of diseases and are important sources for drug discovery. However, to be effectively used in these processes, natural extracts must be characterized through the identification of their active compounds and their modes of action. METHODOLOGY/PRINCIPAL FINDINGS: From an initial set of 29,779 natural products that are annotated with their natural source and using a previously developed virtual screening procedure (carefully validated experimentally, we have predicted as potential peroxisome proliferators-activated receptor gamma (PPARγ partial agonists 12 molecules from 11 extracts known to have antidiabetic activity. Six of these molecules are similar to molecules with described antidiabetic activity but whose mechanism of action is unknown. Therefore, it is plausible that these 12 molecules could be the bioactive molecules responsible, at least in part, for the antidiabetic activity of the extracts containing them. In addition, we have also identified as potential PPARγ partial agonists 10 molecules from 16 plants with undescribed antidiabetic activity but that are related (i.e., they are from the same genus to plants with known antidiabetic properties. None of the 22 molecules that we predict as PPARγ partial agonists show chemical similarity with a group of 211 known PPARγ partial agonists obtained from the literature. CONCLUSIONS/SIGNIFICANCE: Our results provide a new hypothesis about the active molecules of natural extracts with antidiabetic properties and their mode of action. We also suggest plants with undescribed antidiabetic activity that may contain PPARγ partial agonists. These plants represent a new source of potential antidiabetic extracts. Consequently, our work opens the door to the discovery of new antidiabetic extracts and molecules that can be of use, for instance, in the design of new antidiabetic drugs or functional foods focused

  13. Immunogenicity and prediction of epitopic region of antigen Ag I/II and glucosyltransferase from Streptococcus mutans.

    Science.gov (United States)

    Cao, Xi-Xi; Fan, Jian; Chen, Jiang; Li, Yu-Hong; Fan, Ming-Wen

    2016-06-01

    The levels of Streptococcus (S.) mutans infections in saliva were evaluated and a comparison for specific antibody levels among children with different levels of S. mutans infection was made. The promising epitopic regions of antigen AgI/II (PAc) and glucosyltransferase (GTF) for potential vaccine targets related to S. mutans adherence were screened. A total of 94 children aged 3-4 years were randomly selected, including 53 caries-negative and 41 caries-positive children. The values of S. mutans and those of salivary total secretory immunoglobulin A (sIgA), anti-PAc and anti-Glucan binding domain (anti-GLU) were compared to determine the correlation among them. It was found the level of s-IgA against specific antigens did not increase with increasing severity of S. mutans infection, and the complete amino acid sequence of PAc and GTFB was analyzed using the DNAStar Protean system for developing specific anti-caries vaccines related to S. mutans adherence. A significantly positive correlation between the amount of S. mutans and children decayed, missing, and filled teeth index was observed. No significant difference was detected in specific sIgA against PAc or GLU between any two groups. No significant correlation was found between such specific sIgA and caries index. A total of 16 peptides from PAc as well as 13 peptides from GTFB were chosen for further investigation. S. mutans colonization contributed to early children caries as an important etiological factor. The level of sIgA against specific antigens did not increase with increasing severity of S. mutans infection in children. The epitopes of PAc and GTF have been screened to develop the peptide-based or protein-based anti-caries vaccines.

  14. Evaluation of the predictive indices for candidemia in an adult intensive care unit

    Directory of Open Access Journals (Sweden)

    Gilberto Gambero Gaspar

    2015-02-01

    Full Text Available INTRODUCTION: To evaluate predictive indices for candidemia in an adult intensive care unit (ICU and to propose a new index. METHODS: A prospective cohort study was conducted between January 2011 and December 2012. This study was performed in an ICU in a tertiary care hospital at a public university and included 114 patients staying in the adult ICU for at least 48 hours. The association of patient variables with candidemia was analyzed. RESULTS: There were 18 (15.8% proven cases of candidemia and 96 (84.2% cases without candidemia. Univariate analysis revealed the following risk factors: parenteral nutrition, severe sepsis, surgical procedure, dialysis, pancreatitis, acute renal failure, and an APACHE II score higher than 20. For the Candida score index, the odds ratio was 8.50 (95% CI, 2.57 to 28.09; the sensitivity, specificity, positive predictive value, and negative predictive value were 0.78, 0.71, 0.33, and 0.94, respectively. With respect to the clinical predictor index, the odds ratio was 9.45 (95%CI, 2.06 to 43.39; the sensitivity, specificity, positive predictive value, and negative predictive value were 0.89, 0.54, 0.27, and 0.96, respectively. The proposed candidemia index cutoff was 8.5; the sensitivity, specificity, positive predictive value, and negative predictive value were 0.77, 0.70, 0.33, and 0.94, respectively. CONCLUSIONS: The Candida score and clinical predictor index excluded candidemia satisfactorily. The effectiveness of the candidemia index was comparable to that of the Candida score.

  15. Dicopper(II) metallacyclophanes with oligo(p-phenylene-ethynylene) spacers: experimental foundations and theoretical predictions on potential molecular magnetic wires.

    Science.gov (United States)

    Castellano, María; Fortea-Pérez, Francisco R; Bentama, Abdeslem; Stiriba, Salah-Eddine; Julve, Miguel; Lloret, Francesc; De Munno, Giovanni; Armentano, Donatella; Li, Yangling; Ruiz-García, Rafael; Cano, Joan

    2013-07-01

    absorption spectra of 1 and 2 [λ1 = 308 (1) and 316 nm (2)]. In the series of orthogonal model complexes 1-5 with linear oligo(p-phenylene-ethynylene) (OPE) spacers, -C6H4(C≡CC6H4)n- (n = 1-5), a linear increase of the IL π-π* transition energy with the reciprocal of the intermetallic distance is theoretically predicted [νmax = 1.99 × 10(4) + 2.15 × 10(5) (1/r) (S = 0) or ν = 2.01 × 10(4) + 2.18 × 10(5) (1/r) (S = 1)], which clearly indicates that the effective π-conjugation length increases with the number of phenylethyne repeating units. This is accompanied by an exponential decay of the antiferromagnetic coupling with the intermetallic distance [-J = 1.08 × 10(3) exp(-0.31r)], which supports the ability of the extended π-conjugated OPEs to mediate the exchange interaction between the unpaired electrons of the two Cu(II) centers with intermetallic distances in the range of 1.5-4.3 nm. Further developments may be then envisaged for this new family of oxamato-based dicopper(II) oligo-p-phenylethynophanes on the basis of the unique ligand capacity to act as a molecular antiferromagnetic wire.

  16. Development of a web-based liver cancer prediction model for type II diabetes patients by using an artificial neural network.

    Science.gov (United States)

    Rau, Hsiao-Hsien; Hsu, Chien-Yeh; Lin, Yu-An; Atique, Suleman; Fuad, Anis; Wei, Li-Ming; Hsu, Ming-Huei

    2016-03-01

    Diabetes mellitus is associated with an increased risk of liver cancer, and these two diseases are among the most common and important causes of morbidity and mortality in Taiwan. To use data mining techniques to develop a model for predicting the development of liver cancer within 6 years of diagnosis with type II diabetes. Data were obtained from the National Health Insurance Research Database (NHIRD) of Taiwan, which covers approximately 22 million people. In this study, we selected patients who were newly diagnosed with type II diabetes during the 2000-2003 periods, with no prior cancer diagnosis. We then used encrypted personal ID to perform data linkage with the cancer registry database to identify whether these patients were diagnosed with liver cancer. Finally, we identified 2060 cases and assigned them to a case group (patients diagnosed with liver cancer after diabetes) and a control group (patients with diabetes but no liver cancer). The risk factors were identified from the literature review and physicians' suggestion, then, chi-square test was conducted on each independent variable (or potential risk factor) for a comparison between patients with liver cancer and those without, those found to be significant were selected as the factors. We subsequently performed data training and testing to construct artificial neural network (ANN) and logistic regression (LR) prediction models. The dataset was randomly divided into 2 groups: a training group and a test group. The training group consisted of 1442 cases (70% of the entire dataset), and the prediction model was developed on the basis of the training group. The remaining 30% (618 cases) were assigned to the test group for model validation. The following 10 variables were used to develop the ANN and LR models: sex, age, alcoholic cirrhosis, nonalcoholic cirrhosis, alcoholic hepatitis, viral hepatitis, other types of chronic hepatitis, alcoholic fatty liver disease, other types of fatty liver disease, and

  17. Climate Change Effects on Agricultural Production of Iran: II. Predicting Productivity of Field Crops and Adaptation Strategies

    Directory of Open Access Journals (Sweden)

    A Koocheki

    2016-07-01

    Full Text Available Introduction Recent evidences confirm that during the next few decades, many agroclimatic indices of Iran would be affected by global climate change. Koocheki et al. using two General Circulation Models showed that the mean annual temperature of the country will increase between 3.5-4.5°C while mean precipitation will reduce by 7-15% to 2050. It is well established that crop growth and development would drastically affect by the future global warming and its consequences because yield determining processes such as photosynthesis and crop phenology are directly related to temperature. On the other hands, the combined effects of CO2 enrichment and temperature rise on crop growth are complicated and should be studied using crop simulation models. Furthermore, adapting to climatic variability will have a substantially greater effect in reducing impacts than willing mitigation. However, such impacts on crop productivity at national scale and adaptive measures for future conditions are rarely studied in Iran. In this research crop development and yield of wheat, corn, chickpea and sugar beet were simulated for the target year of 2050 and the results are compared with the current yield as the baseline. Materials and Methods Future climatic variables were predicted using A1f (business as usual scenario by GFDL general circulation model and the results were used as weather inputs in the SUCROS model which was previously validated against measured data of the four crops. To account for the effect of CO2 enrichment on crop growth the photosynthesis routine of the model was adopted for increased CO2 concentration using a scaling factor. Changes in developmental stages of each crop were estimated for the future conditions and the relation between duration of these stages and yield was determined. Predicted crop yields for the year 2050 were compared with the current potential yields considering some adaptation strategies. Results and Discussion Results

  18. Developer Initiation and Social Interactions in OSS: A Case Study of the Apache Software Foundation

    Science.gov (United States)

    2014-08-01

    newcomers to software development within Microsoft [48]. Their focus was on understanding how science pedagogy prepares students for the workforce. One...significant amount of the deviance in the model, viz., is the addition of the new variable justified. For all projects projects except Pluto Developer...prediction,” in Proceedings of the ACM SIGSOFT 20th International Symposium on the Foundations of Software Engineering. ACM, 2012, p. 61. 30. F. Rahman, D

  19. Can Early Computed Tomography Angiography after Endovascular Aortic Aneurysm Repair Predict the Need for Reintervention in Patients with Type II Endoleak?

    Energy Technology Data Exchange (ETDEWEB)

    Dudeck, O., E-mail: oliver.dudeck@med.ovgu.de [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany); Schnapauff, D. [Charité Universitätsmedizin Berlin, Department of Radiology (Germany); Herzog, L.; Löwenthal, D.; Bulla, K.; Bulla, B. [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany); Halloul, Z.; Meyer, F. [University of Magdeburg, Department of General, Visceral and Vascular Surgery (Germany); Pech, M. [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany); Gebauer, B. [Charité Universitätsmedizin Berlin, Department of Radiology (Germany); Ricke, J. [University of Magdeburg, Department of Radiology and Nuclear Medicine (Germany)

    2015-02-15

    PurposeThis study was designed to identify parameters on CT angiography (CTA) of type II endoleaks following endovascular aortic aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA), which can be used to predict the subsequent need for reinterventions.MethodsWe retrospectively identified 62 patients with type II endoleak who underwent early CTA in mean 3.7 ± 1.9 days after EVAR. On the basis of follow-up examinations (mean follow-up period 911 days; range, 373–1,987 days), patients were stratified into two groups: those who did (n = 18) and those who did not (n = 44) require reintervention. CTA characteristics, such as AAA, endoleak, as well as nidus dimensions, patency of the inferior mesenteric artery, number of aortic branch vessels, and the pattern of endoleak appearance, were recorded and correlated with the clinical outcome.ResultsUnivariate and receiver operating characteristic curve regression analyses revealed significant differences between the two groups for the endoleak volume (surveillance group: 1391.6 ± 1427.9 mm{sup 3}; reintervention group: 3227.7 ± 2693.8 mm{sup 3}; cutoff value of 2,386 mm{sup 3}; p = 0.002), the endoleak diameter (13.6 ± 4.3 mm compared with 25.9 ± 9.6 mm; cutoff value of 19 mm; p < 0.0001), the number of aortic branch vessels (2.9 ± 1.2 compared with 4.2 ± 1.4 vessels; p = 0.001), as well as a “complex type” endoleak pattern (13.6 %, n = 6 compared with 44.4 %, n = 8; p = 0.02).ConclusionsEarly CTA can predict the future need for reintervention in patients with type II endoleak. Therefore, treatment decision should be based not only on aneurysm enlargement alone but also on other imaging characteristics.

  20. Molecule survival in magnetized protostellar disk winds. II. Predicted H2O line profiles versus Herschel/HIFI observations

    CERN Document Server

    Yvart, W; Forets, G Pineau des; Ferreira, J

    2016-01-01

    We investigate whether the broad wings of H2O emission identified with Herschel towards low-mass Class 0 and Class 1 protostars may be consistent with an origin in a dusty MHD disk wind, and the constraints it would set on the underlying disk properties. We present synthetic H2O line profiles predictions for a typical MHD disk wind solution with various values of disk accretion rate, stellar mass, extension of the launching area, and view angle. We compare them in terms of line shapes and intensities with the HIFI profiles observed by the WISH Key Program. We find that a dusty MHD disk wind launched from 0.2--0.6 AU AU to 3--25 AU can reproduce to a remarkable degree the observed shapes and intensities of the broad H2O component, both in the fundamental 557 GHz line and in more excited lines. Such a model also readily reproduces the observed correlation of 557 GHz line luminosity with envelope density, if the infall rate at 1000 AU is 1--3 times the disk accretion rate in the wind ejection region. It is also ...

  1. Predicting TAS (UC3/UW3 examination success by means of psychological tests- a follow-up study (II

    Directory of Open Access Journals (Sweden)

    Atmananda Sharma

    1960-04-01

    Full Text Available In a preliminary follow-up study of the classification project standard scores made by 118 sailors of UC3/UW3 specialist course of TAS Branch on five psychological tests of mental ability viz., PGIT, VGIT, MCT, MAT and MASYT were correlated between themselves and also with the percentage of marks scored(Obtained score/Maximum marks X 100in the TAS(UC3/UW3examination which acted as the criterion in this study. PGIT, VGIT and MCT were found to the best predictor. Regression coefficients of test scores on the criterion were calculated by the Aitken's method. It was found by analysis of variance that the addition of two tests to PGIT did raise the multiple correlation significantly but other three tests did not raise it significantly. It was concluded that for better prediction of TAS (UC3/UW3 examination success not only should the composition of the test battery be suitably modified by bringing in purer test of differential primary mental abilities but due account must also be taken of personality factors-industriousness, interest etc.,-together with previous service records and assessments by the divisional officer and the school attainments.

  2. Mathematical formulation to predict the harmonics of the superconducting Large Hadron Collider magnets. II. Dynamic field changes and scaling laws

    Directory of Open Access Journals (Sweden)

    Nicholas J. Sammut

    2007-08-01

    Full Text Available A superconducting particle accelerator like the LHC (Large Hadron Collider at CERN, can only be controlled well if the effects of the magnetic field multipoles on the beam are compensated. The demands on a control system solely based on beam feedback may be too high for the requirements to be reached at the specified bandwidth and accuracy. Therefore, we designed a suitable field description for the LHC (FIDEL as part of the machine control baseline to act as a feed-forward magnetic field prediction system. FIDEL consists of a physical and empirical parametric field model based on magnetic measurements at warm and in cryogenic conditions. The performance of FIDEL is particularly critical at injection when the field decays, and in the initial part of the acceleration when the field snaps back. These dynamic components are both current and time dependent and are not reproducible from cycle to cycle since they also depend on the magnet powering history. In this paper a qualitative and quantitative description of the dynamic field behavior substantiated by a set of scaling laws is presented.

  3. The effect of a monocular helmet-mounted display on aircrew health: a 10-year prospective cohort study of Apache AH MK 1 pilots: study midpoint update

    Science.gov (United States)

    Hiatt, Keith L.; Rash, Clarence E.; Watters, Raymond W.; Adams, Mark S.

    2009-05-01

    A collaborative occupational health study has been undertaken by Headquarters Army Aviation, Middle Wallop, UK, and the U.S. Army Aeromedical Research Laboratory, Fort Rucker, Alabama, to determine if the use of the Integrated Helmet and Display Sighting System (IHADSS) monocular helmet-mounted display (HMD) in the Apache AH Mk 1 attack helicopter has any long-term (10-year) effect on visual performance. The test methodology consists primarily of a detailed questionnaire and an annual battery of vision tests selected to capture changes in visual performance of Apache aviators over their flight career (with an emphasis on binocular visual function). Pilots using binocular night vision goggles serve as controls and undergo the same methodology. Currently, at the midpoint of the study, with the exception of a possible colour discrimination effect, there are no data indicating that the long-term use of the IHADSS monocular HMD results in negative effects on vision.

  4. Simulation and Optimization of Artificial Neural Network Modeling for Prediction of Sorption Efficiency of Nanocellulose Fibers for Removal of Cd (II Ions from Aqueous System

    Directory of Open Access Journals (Sweden)

    Abhishek KARDAM

    2014-06-01

    Full Text Available Simulation and optimization of an Artificial Neural Network (ANN for modeling biosorption studies of cadmium removal using nanocellulose fibers (NCFs was carried out. Experimental studies led to the standardization of the optimum conditions for the removal of cadmium ions i.e. biomass dosage (0.5 g, test volume (200 ml, metal concentration (25 mg/l, pH (6.5 and contact time (40 min. A Single layer ANN model was developed to simulate the process and to predict the sorption efficiency of Cd (II ions using NCFs. Different NN architectures were tested by varying network topology, resulting in excellent agreement between experiment outputs and ANN outputs. The findings indicated that ANN provided reasonable predictive performance for training, cross validation and testing data sets (R2 = 0.998, 0.995, 0.992. A sensitivity analysis was carried out to assess the influence of different independent parameters on the biosorption efficiency, and pH > biomass dosage > metal concentration > contact time > test volume were found to be the most significant factors. Simulations based on the developed ANN model can estimate the behavior of the biosorption phenomenon process under different experimental conditions.

  5. 严重脓毒症乳酸清除率、碱剩余与APACHE Ⅱ评分的相关性分析

    Institute of Scientific and Technical Information of China (English)

    黎伟强

    2013-01-01

    Objective To investigate the simple and practical target to forecast of the state and prognosis of the patients with severe sepsis. Mathods Detect Lactate and Base Excess of the 72 patients with severe sepsis after admission, in the same time score the patients with acute physiology and chronic health evaluationⅡ(APACHEⅡ), detect Lactate again after 6 hours ,and calculate Lactate Clearance,compare with Lactate, Lactate Clearance and Base Excess in different groups of APACHE Ⅱ.Results 6 hours Lactate Clearance and Base Excess between 2 groups has statistical signiifcation There are relativity between 6 hours Lactate Clearance, Base Excess and APACHEⅡscore in 48 hours. Conclusion Combing Lactate Clearance and Base Excess can evaluate the state and prognosis of the patients with severe sepsis.%目的探讨预测严重脓毒症患者病情及预后简单易行且有实用价值的指标。方法对72例入住中山市古镇医院ICU严重脓毒症患者入住时作APACHE Ⅱ评分及血乳酸、碱剩余测定,6 h后再次测血乳酸,并计算乳酸清除率,比较不同APACHE Ⅱ评分分值组与血乳酸及乳酸清除率、剩余碱的关系。结果6 h乳酸清除率、碱剩余存活组明显高于死亡组,6 h乳酸清除率及碱剩余与48 hAPACHE Ⅱ评分有相关性。结论乳酸清除率、碱剩余可以作为评估严重脓毒症病情及预后的指标。

  6. 利用Apache+PHP+MySQL架构电子商务平台--PHP网络编程调试平台的实现

    Institute of Scientific and Technical Information of China (English)

    郑汉垣

    2003-01-01

    对各种基于PHP+MySQL编程、调试、应用平台进行了比较,认为最佳PHP+MySQL编程调试平台是Win-dows NT/XP+Apache+PHP+MySQL,并就此平台给出了完整具体的整合安装配置方法与步骤.

  7. TBscore II

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Lemvik, Grethe; Abate, Ebba;

    2013-01-01

    Abstract Background: The TBscore, based on simple signs and symptoms, was introduced to predict unsuccessful outcome in tuberculosis patients on treatment. A recent inter-observer variation study showed profound variation in some variables. Further, some variables depend on a physician assessing...... them, making the score less applicable. The aim of the present study was to simplify the TBscore. Methods: Inter-observer variation assessment and exploratory factor analysis were combined to develop a simplified score, the TBscore II. To validate TBscore II we assessed the association between start...

  8. Predicting the solubility of sulfamethoxypyridazine in individual solvents. II: Relationship between solute-solvent interaction terms and partial solubility parameters.

    Science.gov (United States)

    Martin, A; Bustamante, P; Escalera, B; Sellés, E

    1989-08-01

    In the first paper in the series, an expanded system of parameters was devised to account for orientation and induction effects, and the term Wh was introduced to replace delta 1h delta 2h of the extended Hansen solubility approach. In the present report, a new term, Kh = Wh/delta 1h delta 2h is observed to take on values larger or smaller than unity depending on whether the hydrogen bonded solute-solvent interaction is larger or smaller than predicted by the term delta 1h delta 2h. The acidic delta a and basic delta b solubility parameters are used to represent two parameters, sigma and tau, suggested by Small in his study of proton donor-acceptor properties. The Small equation, including a heat of mixing term for hydrogen bonded species, is shown to be capable of semiquantitative evaluation. A partial molar heat delta H2h of hydrogen bonding is calculated using delta h and Wh terms; delta H2h is found to be correlated with the logarithm of the residual activity coefficient, In alpha R, a term representing strong solute-solvent interaction. The terms Wh, delta H2h, and In alpha 2R may be used to test the deviation from the geometric mean assumed in regular solution theory, and to replace the hydrogen bonding terms of the extended Hansen three-parameter model. The solubility of sulfamethoxypyridazine in 30 solvents is used to test the semiempirical solubility equations. The results are interpreted in terms of partial solubility parameters and the proton donor-acceptor properties of the solvents.

  9. Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: The Whitehall II Prospective Cohort Study

    Science.gov (United States)

    Bouillon, Kim; Kivimäki, Mika; Hamer, Mark; Shipley, Martin J.; Akbaraly, Tasnime N.; Tabak, Adam; Singh-Manoux, Archana; Batty, G. David

    2013-01-01

    Objective To examine whether established diabetes risk factors and diabetes risk algorithms are associated with future frailty. Design Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham Offspring, Cambridge, and Finnish diabetes risk scores. Setting Civil service departments in London, United Kingdom. Participants There were 2707 participants (72% men) aged 45 to 69 years at baseline assessment and free of diabetes. Measurements Risk factors (age, sex, family history of diabetes, body mass index, waist circumference, systolic and diastolic blood pressure, antihypertensive and corticosteroid treatments, history of high blood glucose, smoking status, physical activity, consumption of fruits and vegetables, fasting glucose, HDL-cholesterol, and triglycerides) were used to construct the risk algorithms. Frailty, assessed during a resurvey in 2007–2009, was denoted by the presence of 3 or more of the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength, and weight loss; “prefrailty” was defined as having 2 or fewer of these indicators. Results After a mean follow-up of 10.5 years, 2.8% of the sample was classified as frail and 37.5% as prefrail. Increased age, being female, stopping smoking, low physical activity, and not having a daily consumption of fruits and vegetables were each associated with frailty or prefrailty. The Cambridge and Finnish diabetes risk scores were associated with frailty/prefrailty with odds ratios per 1 SD increase (disadvantage) in score of 1.18 (95% confidence interval: 1.09–1.27) and 1.27 (1.17–1.37), respectively. Conclusion Selected diabetes risk factors and risk scores are associated with subsequent frailty. Risk scores may have utility for frailty prediction in clinical practice. PMID:24103860

  10. APACHE Ⅱ Scoring System in Severe Pre-eclampsia/Eclampsia Prognostic Analysis%APACHEⅡ评分系统在重度子痫前期/子痫患者预后评估分析

    Institute of Scientific and Technical Information of China (English)

    刘颖

    2015-01-01

    目的:探讨 APACHE Ⅱ评分系统用于重度子痫前期/子痫患者预后评估的临床价值。方法选取我院收治的重度子痫前期/子痫患者134例作为研究对象,回顾性分析其临床资料。按照生存状况分为两组,死亡组 4例,生存组130例,均使用 APACHE Ⅱ评分系统,探讨预后评估效果。结果死亡组 APACHE Ⅱ评分与死亡风险明显高于对照组,对比差异有统计学意义(P<0.05)。结论对重度子痫前期、子痫患者采用 APACHE Ⅱ评分系统评估分析其预后有一定效果,但是有一定偏差与局限性。%Objective Discussion APACHE Ⅱ scoring system preeclampsia / eclampsia prognostic value for clinical. Methods Admitted to our hospital with severe preeclampsia / eclampsia 134 cases for the study, a retrospective analysis of the clinical data. Divided into two groups according to the living conditions, death group four cases, 130 cases of survival group, use the scoring system APACHE Ⅱ explore prognostic effect. Results APACHE Ⅱ death group score significantly higher risk of death, compared to the difference was statistically significant (P<0.05). Conclusion Severe preeclampsia, eclampsia patients with APACHE Ⅱ analysis scoring system to assess the prognosis has some effect, but there is a certain bias and limitations.

  11. Bringing colour back after 70 years: Predicting eye and hair colour from skeletal remains of World War II victims using the HIrisPlex system.

    Science.gov (United States)

    Chaitanya, Lakshmi; Pajnič, Irena Zupanič; Walsh, Susan; Balažic, Jože; Zupanc, Tomaž; Kayser, Manfred

    2017-01-01

    Retrieving information about externally visible characteristics from DNA can provide investigative leads to find unknown perpetrators, and can also help in disaster victim and other missing person identification cases. Aiming for the application to both types of forensic casework, we previously developed and forensically validated the HIrisPlex test system enabling parallel DNA prediction of eye and hair colour. Although a recent proof-of-principle study demonstrated the general suitability of the HIrisPlex system for successfully analysing DNA from bones and teeth of various storage times and conditions, practical case applications to human remains are scarce. In this study, we applied the HIrisPlex system to 49 DNA samples obtained from bones or teeth of World War II victims excavated at six sites, mostly mass graves, in Slovenia. PCR-based DNA quantification ranged from 4pg/μl to 313pg/μl and on an average was 41pg/μl across all samples. All 49 samples generated complete HIrisPlex profiles with the exception of one MC1R DNA marker (N29insA) missing in 83.7% of the samples. In 44 of the 49 samples (89.8%) complete 15-loci autosomal STR (plus amelogenin) profiles were obtained. Of 5 pairs of skeletal remains for which STR profiling suggested an origin in the same individuals, respectively, 4 showed the same HIrisPlex profiles and predicted eye and hair colours, respectively, while discrepancies in one pair (sample 26 and 43) are likely to be explained by DNA quantity and quality issues observed in sample 43. Sample 43 had the lowest DNA concentration of only 4pg/μl, producing least reliable STR results and could be misleading in concluding that samples 43 and 26 originate from the same individual. The HIrisPlex-predicted eye and hair colours from two skeletal samples, suggested to derive from two brothers via STR profiling together with a living sister, were confirmed by the living sister's report. Overall, we demonstrate that after more than 70 years, HIris

  12. The Apache Longbow-Hellfire Missile Test at Yuma Proving Ground: Ecological Risk Assessment for Missile Firing

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Daniel Steven [ORNL; Efroymson, Rebecca Ann [ORNL; Hargrove, William Walter [ORNL; Suter, Glenn [U.S. Environmental Protection Agency; Pater, Larry [ERDC-CERL

    2008-01-01

    A multiple stressor risk assessment was conducted at Yuma Proving Ground, Arizona, as a demonstration of the Military Ecological Risk Assessment Framework. The focus was a testing program at Cibola Range, which involved an Apache Longbow helicopter firing Hellfire missiles at moving targets, M60- A1 tanks. This paper describes the ecological risk assessment for the missile launch and detonation. The primary stressor associated with this activity was sound. Other minor stressors included the detonation impact, shrapnel, and fire. Exposure to desert mule deer (Odocoileus hemionus crooki) was quantified using the Army sound contour program BNOISE2, as well as distances from the explosion to deer. Few effects data were available from related studies. Exposure-response models for the characterization of effects consisted of human "disturbance" and hearing damage thresholds in units of C-weighted decibels (sound exposure level) and a distance-based No Observed Adverse Effects Level for moose and cannonfire. The risk characterization used a weight-of-evidence approach and concluded that risk to mule deer behavior from the missile firing was likely for a negligible number of deer, but that no risk to mule deer abundance and reproduction is expected.

  13. Developing Online Communities with LAMP (Linux, Apache, MySQL, PHP) - the IMIA OSNI and CHIRAD Experiences.

    Science.gov (United States)

    Murray, Peter J; Oyri, Karl

    2005-01-01

    Many health informatics organisations do not seem to use, on a practical basis, for the benefit of their activities and interaction with their members, the very technologies that they often promote for use within healthcare environments. In particular, many organisations seem to be slow to take up the benefits of interactive web technologies. This paper presents an introduction to some of the many free/libre and open source (FLOSS) applications currently available and using the LAMP - Linux, Apache, MySQL, PHP architecture - as a way of cheaply deploying reliable, scalable, and secure web applications. The experience of moving to applications using LAMP architecture, in particular that of the Open Source Nursing Informatics (OSNI) Working Group of the Special Interest Group in Nursing Informatics of the International Medical Informatics Association (IMIA-NI), in using PostNuke, a FLOSS Content Management System (CMS) illustrates many of the benefits of such applications. The experiences of the authors in installing and maintaining a large number of websites using FLOSS CMS to develop dynamic, interactive websites that facilitate real engagement with the members of IMIA-NI OSNI, the IMIA Open Source Working Group, and the Centre for Health Informatics Research and Development (CHIRAD), as well as other organisations, is used as the basis for discussing the potential benefits that could be realised by others within the health informatics community.

  14. The Apache Point Observatory Galactic Evolution Experiment (APOGEE) high-resolution near-infrared multi-object fiber spectrograph

    Science.gov (United States)

    Wilson, John C.; Hearty, Fred; Skrutskie, Michael F.; Majewski, Steven; Schiavon, Ricardo; Eisenstein, Daniel; Gunn, Jim; Blank, Basil; Henderson, Chuck; Smee, Stephen; Barkhouser, Robert; Harding, Al; Fitzgerald, Greg; Stolberg, Todd; Arns, Jim; Nelson, Matt; Brunner, Sophia; Burton, Adam; Walker, Eric; Lam, Charles; Maseman, Paul; Barr, Jim; Leger, French; Carey, Larry; MacDonald, Nick; Horne, Todd; Young, Erick; Rieke, George; Rieke, Marcia; O'Brien, Tom; Hope, Steve; Krakula, John; Crane, Jeff; Zhao, Bo; Carr, Mike; Harrison, Craig; Stoll, Robert; Vernieri, Mary A.; Holtzman, Jon; Shetrone, Matt; Allende-Prieto, Carlos; Johnson, Jennifer; Frinchaboy, Peter; Zasowski, Gail; Bizyaev, Dmitry; Gillespie, Bruce; Weinberg, David

    2010-07-01

    The Apache Point Observatory Galactic Evolution Experiment (APOGEE) will use a dedicated 300-fiber, narrow-band (1.5-1.7 micron), high resolution (R~30,000), near-infrared spectrograph to survey approximately 100,000 giant stars across the Milky Way. This survey, conducted as part of the Sloan Digital Sky Survey III (SDSS III), will revolutionize our understanding of kinematical and chemical enrichment histories of all Galactic stellar populations. The instrument, currently in fabrication, will be housed in a separate building adjacent to the 2.5 m SDSS telescope and fed light via approximately 45-meter fiber runs from the telescope. The instrument design includes numerous technological challenges and innovations including a gang connector that allows simultaneous connection of all fibers with a single plug to a telescope cartridge that positions the fibers on the sky, numerous places in the fiber train in which focal ratio degradation must be minimized, a large (290 mm x 475 mm elliptically-shaped recorded area) mosaic-VPH, an f/1.4 sixelement refractive camera featuring silicon and fused silica elements with diameters as large as 393 mm, three near-within a custom, LN2-cooled, stainless steel vacuum cryostat with dimensions 1.4 m x 2.3 m x 1.3 m.

  15. Data collection and field experiments at the Apache Leap research site. Annual report, May 1995--1996

    Energy Technology Data Exchange (ETDEWEB)

    Woodhouse, E.G. [ed.; Bassett, R.L.; Neuman, S.P.; Chen, G. [and others

    1997-08-01

    This report documents the research performed during the period May 1995-May 1996 for a project of the U.S. Regulatory Commission (sponsored contract NRC-04-090-051) by the University of Arizona. The project manager for this research in Thomas J. Nicholson, Office of Nuclear Regulatory Research. The objectives of this research were to examine hypotheses and test alternative conceptual models concerning unsaturated flow and transport through fractured rock, and to design and execute confirmatory field and laboratory experiments to test these hypotheses and conceptual models at the Apache Leap Research Site near Superior, Arizona. Each chapter in this report summarizes research related to a specific set of objectives and can be read and interpreted as a separate entity. Topics include: crosshole pneumatic and gaseous tracer field and modeling experiments designed to help validate the applicability of contiuum geostatistical and stochastic concepts, theories, models, and scaling relations relevant to unsaturated flow and transport in fractured porous tuffs; use of geochemistry and aquifer testing to evaluate fracture flow and perching mechanisms; investigations of {sup 234}U/{sup 238}U fractionation to evaluate leaching selectivity; and transport and modeling of both conservative and non-conservative tracers.

  16. Overview of the SDSS-IV MaNGA Survey: Mapping Nearby Galaxies at Apache Point Observatory

    CERN Document Server

    Bundy, Kevin; Law, David R; Yan, Renbin; Drory, Niv; MacDonald, Nicholas; Wake, David A; Cherinka, Brian; Sánchez-Gallego, José R; Weijmans, Anne-Marie; Thomas, Daniel; Tremonti, Christy; Masters, Karen; Coccato, Lodovico; Diamond-Stanic, Aleksandar M; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco; Bizyaev, Dmitry; Blanc, Guillermo A; Bland-Hawthorn, Joss; Blanton, Michael R; Brownstein, Joel R; Byler, Nell; Cappellari, Michele; Conroy, Charlie; Dutton, Aaron A; Emsellem, Eric; Etherington, James; Frinchaboy, Peter M; Fu, Hai; Gunn, James E; Harding, Paul; Johnston, Evelyn J; Kauffmann, Guinevere; Kinemuchi, Karen; Klaene, Mark A; Knapen, Johan H; Leauthaud, Alexie; Li, Cheng; Lin, Lihwai; Maiolino, Roberto; Malanushenko, Viktor; Malanushenko, Elena; Mao, Shude; Maraston, Claudia; McDermid, Richard M; Merrifield, Michael R; Nichol, Robert C; Oravetz, Daniel; Pan, Kaike; Parejko, John K; Sanchez, Sebastian F; Schlegel, David; Simmons, Audrey; Steele, Oliver; Steinmetz, Matthias; Thanjavur, Karun; Thompson, Benjamin A; Tinker, Jeremy L; Bosch, Remco C E van den; Westfall, Kyle B; Wilkinson, David; Wright, Shelley; Xiao, Ting; Zhang, Kai

    2014-01-01

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12" (19 fibers) to 32" (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 A at R~2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (per A, per 2" fiber) at 23 AB mag per sq. arcsec, which is typical for the outskirts of ...

  17. Prediction of the spin transition temperature in Fe(II) one-dimensional coordination polymers: an anion based database.

    Science.gov (United States)

    Dîrtu, Marinela M; Rotaru, Aurelian; Gillard, Damien; Linares, Jorge; Codjovi, Epiphane; Tinant, Bernard; Garcia, Yann

    2009-08-17

    One-dimensional (1D) coordination polymers of formula [Fe(NH(2)trz)(3)]A.nH(2)O, {A = TiF(6)(2-), n = 0.5 (1) and n = 1 (2); A = ZrF(6)(2-), n = 0.5 (3) and n = 0 (4); A = SnF(6)(2-), n = 0.5 (5) and n = 1 (6); A = TaF(7)(2-), n = 3 (7) and n = 2.5 (8); A = GeF(6)(2-), n = 1 (9) and n = 0.5 (10), NH(2)trz = 4-amino-1,2,4-triazole} have been synthesized, fully characterized, and their spin crossover behavior carefully studied by SQUID magnetometry, Mossbauer spectroscopy, and differential scanning calorimetry. These materials display an abrupt and hysteretic spin transition around 200 K on cooling, as well as a reversible thermochromic effect. Accurate spin transition curves were derived by (57)Fe Mossbauer spectroscopy considering the corrected f factors for the high-spin and low-spin states determined employing the Debye model. The unusual hysteresis width of 3 (28 K), was attributed to a dense hydrogen bonding network involving the ZrF(6)(2-) counteranion and the 1D chains, an organization which is also revealed in [Cu(NH(2)trz)(3)]ZrF(6).H(2)O (11). Trinuclear spin crossover compounds of formula [Fe(3)(NH(2)trz)(10)(H(2)O)(2)](SbF(6))(6).S {S = 1.5CH(3)OH (12), 0.5C(2)H(5)OH (13)} were also obtained. A structural property relationship was derived between the volume of the inserted counteranion and the transition temperature T(1/2) of the 1D chains. Two linear size regimes were identified for monovalent anions (0.04 or= 0.11 nm(3)) with saturation around T(1/2) = 200 K. These characteristics allowed us to derive an anion based database that is of interest for the prediction of the transition temperature of such functional switchable materials. Diffuse reflectivity measurements under hydrostatic pressure for 3,4 combined with calorimetric data allow an estimation of the electrostatic pressure between cationic chains and counteranions in the crystal lattice of these materials. The chain length distribution that ranges between 1 and 4 nm was also derived.

  18. cobalt (ii), nickel (ii)

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. The manganese (II), cobalt (II), nickel (II) and copper (II) complexes of N, N' – ... temperature and coordinated water were determined ... indicating fairly stable complex compounds (Table 1). The complex compounds are insoluble [Table 2] in water and common organic solvents, but are readily soluble in ...

  19. Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation

    Science.gov (United States)

    Michael, G; Dempster, J; Kane, K A; Coker, S J

    2007-01-01

    Background and purpose: Torsade de pointes (TdP) can be induced by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether I Ks blockade or enhancement of I Na could potentiate TdP induced by I Kr blockade and to investigate whether short-term variability (STV) or triangulation of action potentials preceded TdP. Experimental approach: Experiments were performed in open-chest, pentobarbital-anaesthetized, α1-adrenoceptor-stimulated, male New Zealand White rabbits, which received three consecutive i.v. infusions of either the I Kr blocker E-4031 (1, 3 and 10 nmol kg−1 min−1), the I Ks blocker HMR1556 (25, 75 and 250 nmol kg−1 min−1) or E-4031 and HMR1556 combined. In a second study rabbits received either the same doses of E-4031, the I Na enhancer, ATX-II (0.4, 1.2 and 4.0 nmol kg−1) or both of these drugs. ECGs and epicardial monophasic action potentials were recorded. Key results: HMR1556 alone did not cause TdP but increased E-4031-induced TdP from 25 to 80%. ATX-II alone caused TdP in 38% of rabbits, as did E-4031; 75% of rabbits receiving both drugs had TdP. QT intervals were prolonged by all drugs but the extent of QT prolongation was not related to the occurrence of TdP. No changes in STV were detected and triangulation was only increased after TdP occurred. Conclusions and implications: Giving modulators of ion channels in combination substantially increased TdP but, in this model, neither STV nor triangulation of action potentials could predict TdP. PMID:17965747

  20. Copeptin Predicts Mortality in Critically Ill Patients

    Science.gov (United States)

    Krychtiuk, Konstantin A.; Honeder, Maria C.; Lenz, Max; Maurer, Gerald; Wojta, Johann; Heinz, Gottfried; Huber, Kurt; Speidl, Walter S.

    2017-01-01

    Background Critically ill patients admitted to a medical intensive care unit exhibit a high mortality rate irrespective of the cause of admission. Besides its role in fluid and electrolyte balance, vasopressin has been described as a stress hormone. Copeptin, the C-terminal portion of provasopressin mirrors vasopressin levels and has been described as a reliable biomarker for the individual’s stress level and was associated with outcome in various disease entities. The aim of this study was to analyze whether circulating levels of copeptin at ICU admission are associated with 30-day mortality. Methods In this single-center prospective observational study including 225 consecutive patients admitted to a tertiary medical ICU at a university hospital, blood was taken at ICU admission and copeptin levels were measured using a commercially available automated sandwich immunofluorescent assay. Results Median acute physiology and chronic health evaluation II score was 20 and 30-day mortality was 25%. Median copeptin admission levels were significantly higher in non-survivors as compared with survivors (77.6 IQR 30.7–179.3 pmol/L versus 45.6 IQR 19.6–109.6 pmol/L; p = 0.025). Patients with serum levels of copeptin in the third tertile at admission had a 2.4-fold (95% CI 1.2–4.6; p = 0.01) increased mortality risk as compared to patients in the first tertile. When analyzing patients according to cause of admission, copeptin was only predictive of 30-day mortality in patients admitted due to medical causes as opposed to those admitted after cardiac surgery, as medical patients with levels of copeptin in the highest tertile had a 3.3-fold (95% CI 1.66.8, p = 0.002) risk of dying independent from APACHE II score, primary diagnosis, vasopressor use and need for mechanical ventilation. Conclusion Circulating levels of copeptin at ICU admission independently predict 30-day mortality in patients admitted to a medical ICU. PMID:28118414

  1. Identification of Novel Circulating Biomarkers Predicting Rapid Decline in Renal Function in Type 2 Diabetes: The Fremantle Diabetes Study Phase II.

    Science.gov (United States)

    Peters, Kirsten E; Davis, Wendy A; Ito, Jun; Winfield, Kaye; Stoll, Thomas; Bringans, Scott D; Lipscombe, Richard J; Davis, Timothy M E

    2017-08-29

    To assess the ability of plasma apolipoprotein (apo) A-IV (apoA4), apo C-III, CD5 antigen-like (CD5L), complement C1q subcomponent subunit B (C1QB), complement factor H-related protein 2, and insulin-like growth factor binding protein 3 (IBP3) to predict rapid decline in estimated glomerular filtration rate (eGFR) in type 2 diabetes. Mass spectrometry was used to measure baseline biomarkers in 345 community-based patients (mean age 67.0 years, 51.9% males) from the Fremantle Diabetes Study Phase II. Multiple logistic regression was used to determine clinical predictors of rapid eGFR decline trajectory defined by semiparametric group-based modeling over a 4-year follow-up period. The incremental benefit of each biomarker was then assessed. Similar analyses were performed for a ≥30% eGFR fall, incident chronic kidney disease (eGFR <60 mL/min/1.73 m(2)), and eGFR decline of ≥5 mL/min/1.73 m(2)/year. Based on eGFR trajectory analysis, 35 participants (10.1%) were defined as "rapid decliners" (mean decrease 2.9 mL/min/1.73 m(2)/year). After adjustment for clinical predictors, apoA4, CD5L, and C1QB independently predicted rapid decline (odds ratio 2.40 [95% CI 1.24-4.61], 0.52 [0.29-0.93], and 2.41 [1.14-5.11], respectively) and improved model performance and fit (P < 0.001), discrimination (area under the curve 0.75-0.82, P = 0.039), and reclassification (net reclassification index 0.76 [0.63-0.89]; integrated discrimination improvement 6.3% [2.1-10.4%]). These biomarkers and IBP3 contributed to improved model performance in predicting other indices of rapid eGFR decline. The current study has identified novel plasma biomarkers (apoA4, CD5L, C1QB, and IBP3) that may improve the prediction of rapid decline in renal function independently of recognized clinical risk factors in type 2 diabetes. © 2017 by the American Diabetes Association.

  2. Comparison of midlatitude ionospheric F region peak parameters and topside Ne profiles from IRI2012 model prediction with ground-based ionosonde and Alouette II observations

    Science.gov (United States)

    Gordiyenko, G. I.; Yakovets, A. F.

    2017-07-01

    The ionospheric F2 peak parameters recorded by a ground-based ionosonde at the midlatitude station Alma-Ata [43.25N, 76.92E] were compared with those obtained using the latest version of the IRI model (http://omniweb.gsfc.nasa.gov/vitmo/iri2012_vitmo.html). It was found that for the Alma-Ata (Kazakhstan) location, the IRI2012 model describes well the morphology of seasonal and diurnal variations of the ionospheric critical frequency (foF2) and peak density height (hmF2) monthly medians. The model errors in the median foF2 prediction (percentage deviations between the median foF2 values and their model predictions) were found to vary approximately in the range from about -20% to 34% and showed a stable overestimation in the median foF2 values for daytime in January and July and underestimation for day- and nighttime hours in the equinoctial months. The comparison between the ionosonde hmF2 and IRI results clearly showed that the IRI overestimates the nighttime hmF2 values for March and September months, and the difference is up to 30 km. The daytime Alma-Ata hmF2 data were found to be close to the IRI predictions (deviations are approximately ±10-15 km) in winter and equinoctial months, except in July when the observed hmF2 values were much more (from approximately 50-200 km). The comparison between the Alouette foF2 data and IRI predictions showed mixed results. In particular, the Alouette foF2 data showed a tendency to be overestimated for daytime in winter months similar to the ionosonde data; however, the overestimated foF2 values for nighttime in the autumn equinox were in disagreement with the ionosonde observations. There were large deviations between the observed hmF2 values and their model predictions. The largest deviations were found during winter and summer (up to -90 km). The comparison of the Alouette II electron density profiles with those predicted by the adapted IRI2012 model in the altitude range hmF2 of the satellite position showed a great

  3. Escoliose idiopática do adolescente King II (Lenke B e C: predição da descompensação coronal King II adolescent idiopathic scoliosis (Lenke B and C: prediction of coronal decompensation

    Directory of Open Access Journals (Sweden)

    Osmar Avanzi

    2010-01-01

    Full Text Available OBJETIVO: Identificar os sinais radiográficos preditivos de descompensação do tronco em pacientes com EIA King II (Lenke B e C submetidos a artrodese torácica seletiva com material de terceira geração. MÉTODOS: Foram avaliadas retrospectivamente as radiografias pré-operatórias e do último acompanhamento de 22 pacientes. A amostra foi dividida em dois grupos: pacientes compensados após o tratamento (n=18 e os pacientes que apresentaram descompensação coronal (n=4. Esses dois grupos foram comparados para analisar possíveis critérios radiográficos pré-operatórios preditivos da descompensação do tronco. RESULTADOS: Os pacientes que evoluíram com descompensação coronal do tronco apresentaram maior valor angular, maior translação e maior rotação da vértebra apical da curva lombar e maior obliqüidade de L4 em relação à pelve. Além disso, a relação entre a curva torácica para os critérios de valor angular, TVA e RVA foi menor, quando comparadas com os pacientes com boa evolução. CONCLUSÕES: Curvas lombares compensatórias com valor angular semelhante à curva torácica principal, com translação e rotação da vértebra apical elevadas e grande inclinação de L4 apresentam alta probabilidade de descompensação do tronco após o tratamento cirúrgico. O número pequeno de pacientes descompensados não permitiu definir valores preditivos destas variáveis.OBJECTIVE: To identify the predictive radiographic signs of trunk decompensation in King II AIS patients (Lenke B and C who underwent selective thoracic arthrodesis with third generation material. METHODS: A retrospective analysis was carried out of the preoperative radiographies, and those from the most recent follow-up, of twenty-two patients. The sample was divided in two groups: patients compensated after treatment (n=18 and patients who presented coronal decompensation (n=4. The two groups were compared to analyse possible postoperative predictive

  4. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Vinicius M. [Laboratory of Molecular Modeling and Design, Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO 74605-220 (Brazil); Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States); Muratov, Eugene [Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States); Laboratory of Theoretical Chemistry, A.V. Bogatsky Physical–Chemical Institute NAS of Ukraine, Odessa 65080 (Ukraine); Fourches, Denis [Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States); Strickland, Judy; Kleinstreuer, Nicole [ILS/Contractor supporting the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), P.O. Box 13501, Research Triangle Park, NC 27709 (United States); Andrade, Carolina H. [Laboratory of Molecular Modeling and Design, Faculty of Pharmacy, Federal University of Goiás, Goiânia, GO 74605-220 (Brazil); Tropsha, Alexander, E-mail: alex_tropsha@unc.edu [Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599 (United States)

    2015-04-15

    Skin permeability is widely considered to be mechanistically implicated in chemically-induced skin sensitization. Although many chemicals have been identified as skin sensitizers, there have been very few reports analyzing the relationships between molecular structure and skin permeability of sensitizers and non-sensitizers. The goals of this study were to: (i) compile, curate, and integrate the largest publicly available dataset of chemicals studied for their skin permeability; (ii) develop and rigorously validate QSAR models to predict skin permeability; and (iii) explore the complex relationships between skin sensitization and skin permeability. Based on the largest publicly available dataset compiled in this study, we found no overall correlation between skin permeability and skin sensitization. In addition, cross-species correlation coefficient between human and rodent permeability data was found to be as low as R{sup 2} = 0.44. Human skin permeability models based on the random forest method have been developed and validated using OECD-compliant QSAR modeling workflow. Their external accuracy was high (Q{sup 2}{sub ext} = 0.73 for 63% of external compounds inside the applicability domain). The extended analysis using both experimentally-measured and QSAR-imputed data still confirmed the absence of any overall concordance between skin permeability and skin sensitization. This observation suggests that chemical modifications that affect skin permeability should not be presumed a priori to modulate the sensitization potential of chemicals. The models reported herein as well as those developed in the companion paper on skin sensitization suggest that it may be possible to rationally design compounds with the desired high skin permeability but low sensitization potential. - Highlights: • It was compiled the largest publicly-available skin permeability dataset. • Predictive QSAR models were developed for skin permeability. • No concordance between skin

  5. Interrogating and predicting tolerated sequence diversity in protein folds: application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein.

    Directory of Open Access Journals (Sweden)

    Jennifer L Lahti

    2009-09-01

    Full Text Available Cystine-knot miniproteins (knottins are promising molecular scaffolds for protein engineering applications. Members of the knottin family have multiple loops capable of displaying conformationally constrained polypeptides for molecular recognition. While previous studies have illustrated the potential of engineering knottins with modified loop sequences, a thorough exploration into the tolerated loop lengths and sequence space of a knottin scaffold has not been performed. In this work, we used the Ecballium elaterium trypsin inhibitor II (EETI as a model member of the knottin family and constructed libraries of EETI loop-substituted variants with diversity in both amino acid sequence and loop length. Using yeast surface display, we isolated properly folded EETI loop-substituted clones and applied sequence analysis tools to assess the tolerated diversity of both amino acid sequence and loop length. In addition, we used covariance analysis to study the relationships between individual positions in the substituted loops, based on the expectation that correlated amino acid substitutions will occur between interacting residue pairs. We then used the results of our sequence and covariance analyses to successfully predict loop sequences that facilitated proper folding of the knottin when substituted into EETI loop 3. The sequence trends we observed in properly folded EETI loop-substituted clones will be useful for guiding future protein engineering efforts with this knottin scaffold. Furthermore, our findings demonstrate that the combination of directed evolution with sequence and covariance analyses can be a powerful tool for rational protein engineering.

  6. Novel Bioinformatics–Based Approach for Proteomic Biomarkers Prediction of Calpain-2 & Caspase-3 Protease Fragmentation: Application to βII-Spectrin Protein

    Science.gov (United States)

    El-Assaad, Atlal; Dawy, Zaher; Nemer, Georges; Kobeissy, Firas

    2017-01-01

    The crucial biological role of proteases has been visible with the development of degradomics discipline involved in the determination of the proteases/substrates resulting in breakdown-products (BDPs) that can be utilized as putative biomarkers associated with different biological-clinical significance. In the field of cancer biology, matrix metalloproteinases (MMPs) have shown to result in MMPs-generated protein BDPs that are indicative of malignant growth in cancer, while in the field of neural injury, calpain-2 and caspase-3 proteases generate BDPs fragments that are indicative of different neural cell death mechanisms in different injury scenarios. Advanced proteomic techniques have shown a remarkable progress in identifying these BDPs experimentally. In this work, we present a bioinformatics-based prediction method that identifies protease-associated BDPs with high precision and efficiency. The method utilizes state-of-the-art sequence matching and alignment algorithms. It starts by locating consensus sequence occurrences and their variants in any set of protein substrates, generating all fragments resulting from cleavage. The complexity exists in space O(mn) as well as in O(Nmn) time, where N, m, and n are the number of protein sequences, length of the consensus sequence, and length per protein sequence, respectively. Finally, the proposed methodology is validated against βII-spectrin protein, a brain injury validated biomarker.

  7. Novel Bioinformatics–Based Approach for Proteomic Biomarkers Prediction of Calpain-2 & Caspase-3 Protease Fragmentation: Application to βII-Spectrin Protein

    Science.gov (United States)

    El-Assaad, Atlal; Dawy, Zaher; Nemer, Georges; Kobeissy, Firas

    2017-01-01

    The crucial biological role of proteases has been visible with the development of degradomics discipline involved in the determination of the proteases/substrates resulting in breakdown-products (BDPs) that can be utilized as putative biomarkers associated with different biological-clinical significance. In the field of cancer biology, matrix metalloproteinases (MMPs) have shown to result in MMPs-generated protein BDPs that are indicative of malignant growth in cancer, while in the field of neural injury, calpain-2 and caspase-3 proteases generate BDPs fragments that are indicative of different neural cell death mechanisms in different injury scenarios. Advanced proteomic techniques have shown a remarkable progress in identifying these BDPs experimentally. In this work, we present a bioinformatics-based prediction method that identifies protease-associated BDPs with high precision and efficiency. The method utilizes state-of-the-art sequence matching and alignment algorithms. It starts by locating consensus sequence occurrences and their variants in any set of protein substrates, generating all fragments resulting from cleavage. The complexity exists in space O(mn) as well as in O(Nmn) time, where N, m, and n are the number of protein sequences, length of the consensus sequence, and length per protein sequence, respectively. Finally, the proposed methodology is validated against βII-spectrin protein, a brain injury validated biomarker. PMID:28112201

  8. The predictive value of proteinuria in acute pancreatitis.

    Science.gov (United States)

    Zuidema, M J; van Santvoort, H C; Besselink, M G; van Ramshorst, B; Boerma, D; Timmer, R; Bollen, T L; Weusten, B L A M

    2014-01-01

    Acute pancreatitis has a highly variable clinical course. Early and reliable predictors for the severity of acute pancreatitis are lacking. Proteinuria appears to be a useful predictor of disease severity and outcome in a variety of clinical conditions. This study aims to investigate the predictive value of proteinuria on admission for the severity of acute pancreatitis compared with other commonly used predictors; the APACHE II score, Modified Glasgow score and C-reactive protein (CRP). This is a post-hoc analysis of 64 patients admitted with acute pancreatitis treated in one teaching hospital, who participated in a previous randomized trial. Proteinuria was defined as a Protein/Creatinine (P/C) ratio >23 mg/mmol. The primary endpoint was severe acute pancreatitis. Secondary endpoints included infectious complications, need for invasive intervention, ICU stay and in-hospital mortality. Proteinuria was present in 30/64 patients (47%). Eleven patients (17%) had severe acute pancreatitis. There was no difference in incidence of severe acute pancreatitis between patients with and without proteinuria: 6/30 patients (20%) versus 5/34 patients (15%) respectively (p = 0.58). Likewise, the occurrence of infectious complications, need for intervention and ICU stay and mortality did not differ significantly (p = 0.58, p = 0.99, p = 0.33 and p = 0.60 respectively). The diagnostic performance of the P/C ratio for the prediction of severe pancreatitis was inferior to the Modified Glasgow score (p = 0.04) and CRP (p = 0.03). Proteinuria on admission does not seem to be a reliable predictor for disease severity in acute pancreatitis. The diagnostic performance of the P/C ratio is inferior to the Modified Glasgow score and CRP. Copyright © 2014 IAP and EPC. Published by Elsevier B.V. All rights reserved.

  9. OVERVIEW OF THE SDSS-IV MaNGA SURVEY: MAPPING NEARBY GALAXIES AT APACHE POINT OBSERVATORY

    Energy Technology Data Exchange (ETDEWEB)

    Bundy, Kevin [Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwa 277-8583 (Japan); Bershady, Matthew A.; Wake, David A.; Tremonti, Christy; Diamond-Stanic, Aleksandar M. [Department of Astronomy, University of Wisconsin-Madison, 475 North Charter Street, Madison, WI 53706 (United States); Law, David R.; Cherinka, Brian [Dunlap Institute for Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, Ontario M5S 3H4 (Canada); Yan, Renbin; Sánchez-Gallego, José R. [Department of Physics and Astronomy, University of Kentucky, 505 Rose Street, Lexington, KY 40506-0055 (United States); Drory, Niv [McDonald Observatory, Department of Astronomy, University of Texas at Austin, 1 University Station, Austin, TX 78712-0259 (United States); MacDonald, Nicholas [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Weijmans, Anne-Marie [School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews KY16 9SS (United Kingdom); Thomas, Daniel; Masters, Karen; Coccato, Lodovico [Institute of Cosmology and Gravitation, University of Portsmouth, Portsmouth (United Kingdom); Aragón-Salamanca, Alfonso [School of Physics and Astronomy, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Avila-Reese, Vladimir [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, A.P. 70-264, 04510 Mexico D.F. (Mexico); Badenes, Carles [Department of Physics and Astronomy and Pittsburgh Particle Physics, Astrophysics and Cosmology Center (PITT PACC), University of Pittsburgh, 3941 OHara St, Pittsburgh, PA 15260 (United States); Falcón-Barroso, Jésus [Instituto de Astrofísica de Canarias, E-38200 La Laguna, Tenerife (Spain); Belfiore, Francesco [Cavendish Laboratory, University of Cambridge, 19 J. J. Thomson Avenue, Cambridge CB3 0HE (United Kingdom); and others

    2015-01-01

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 Å at R ∼ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (Å{sup –1} per 2'' fiber) at 23 AB mag arcsec{sup –2}, which is typical for the outskirts of MaNGA galaxies. Targets are selected with M {sub *} ≳ 10{sup 9} M {sub ☉} using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr.

  10. High precision gravity analysis and hydrological modeling from the Lunar Laser Ranging Observatory at Apache Point, New Mexico

    Science.gov (United States)

    Liang, Jiahao

    The NASA-supported Lunar Laser Ranging project (LLR) is located at Apache Point, New Mexico, which strives to precisely measure the orbital distance between the Earth and the Moon in an accuracy of a few millimeters. To archive this objective, LLR project requires precise data on local ground deformation, which is difficult to measure directly. However, the high precision gravity data is the reflection of vertical ground deformation of the Earth, therefore the gravity data is able to contribute to the LLR project. Gravity time series is affected by Earth tides, atmospheric pressure, polar motion, and the most critical effect, local hydrology. In order to isolate pure geodetic variation, these effects must be removed from the data. Thus, the goal of this research is to create models of above effects, especially local hydrology model, in order to isolate the vertical deformation signal. The Earth tides, atmospheric pressure and polar motion effects have been modeled and subtracted from gravity data (2009~2012). The local hydrological model has been created based on the in-situ data, which are rainfall, snowfall and temperature. The correlation coefficient and RMS misfit between the hydrological model and gravity residual (2010~2012) is 0.92 and 1.26 microGal. The instrument drift corrections in 2009 have been reanalyzed after comparing with some global hydrological models. The gravity residual from new corrections showed a correlation coefficient of 0.76 and RMS misfit of 1.25 microGal. The isolated deformation signal was obtained after we subtracted the hydrological effects, and the results can be used for further modeling.

  11. Overview of the SDSS-IV MaNGA Survey: Mapping nearby Galaxies at Apache Point Observatory

    Science.gov (United States)

    Bundy, Kevin; Bershady, Matthew A.; Law, David R.; Yan, Renbin; Drory, Niv; MacDonald, Nicholas; Wake, David A.; Cherinka, Brian; Sánchez-Gallego, José R.; Weijmans, Anne-Marie; Thomas, Daniel; Tremonti, Christy; Masters, Karen; Coccato, Lodovico; Diamond-Stanic, Aleksandar M.; Aragón-Salamanca, Alfonso; Avila-Reese, Vladimir; Badenes, Carles; Falcón-Barroso, Jésus; Belfiore, Francesco; Bizyaev, Dmitry; Blanc, Guillermo A.; Bland-Hawthorn, Joss; Blanton, Michael R.; Brownstein, Joel R.; Byler, Nell; Cappellari, Michele; Conroy, Charlie; Dutton, Aaron A.; Emsellem, Eric; Etherington, James; Frinchaboy, Peter M.; Fu, Hai; Gunn, James E.; Harding, Paul; Johnston, Evelyn J.; Kauffmann, Guinevere; Kinemuchi, Karen; Klaene, Mark A.; Knapen, Johan H.; Leauthaud, Alexie; Li, Cheng; Lin, Lihwai; Maiolino, Roberto; Malanushenko, Viktor; Malanushenko, Elena; Mao, Shude; Maraston, Claudia; McDermid, Richard M.; Merrifield, Michael R.; Nichol, Robert C.; Oravetz, Daniel; Pan, Kaike; Parejko, John K.; Sanchez, Sebastian F.; Schlegel, David; Simmons, Audrey; Steele, Oliver; Steinmetz, Matthias; Thanjavur, Karun; Thompson, Benjamin A.; Tinker, Jeremy L.; van den Bosch, Remco C. E.; Westfall, Kyle B.; Wilkinson, David; Wright, Shelley; Xiao, Ting; Zhang, Kai

    2015-01-01

    We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 Å at R ~ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (Å-1 per 2'' fiber) at 23 AB mag arcsec-2, which is typical for the outskirts of MaNGA galaxies. Targets are selected with M * >~ 109 M ⊙ using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr.

  12. Perfusion-CT--Can We Predict Acute Pancreatitis Outcome within the First 24 Hours from the Onset of Symptoms?

    Directory of Open Access Journals (Sweden)

    Joanna Pieńkowska

    Full Text Available Severe acute pancreatitis (AP is still a significant clinical problem which is associated with a highly mortality. The aim of this study was the evaluation of prognostic value of CT regional perfusion measurement performed on the first day of onset of symptoms of AP, in assessing the risk of developing severe form of acute pancreatitis.79 patients with clinical symptoms and biochemical criteria indicative of acute pancreatitis (acute upper abdominal pain, elevated levels of serum amylase and lipase underwent perfusion CT within 24 hours after onset of symptoms. The follow-up examinations were performed after 4-6 days to detect progression of the disease. Perfusion parameters were compared in 41 people who developed severe form of AP (pancreatic and/or peripancreatic tissue necrosis with parameters in 38 consecutive patients in whom course of AP was mild. Blood flow, blood volume, mean transit time and permeability surface area product were calculated in the three anatomic pancreatic subdivisions (head, body and tail. At the same time the patient's clinical status was assessed by APACHE II score and laboratory parameters such as CRP, serum lipase and amylase, AST, ALT, GGT, ALP and bilirubin were compared.Statistical differences in the perfusion parameters between the group of patients with mild and severe AP were shown. Blood flow, blood volume and mean transit time were significantly lower and permeability surface area product was significantly higher in patients who develop severe acute pancreatitis and presence of pancreatic and/or peripancreatic necrosis due to pancreatic ischemia. There were no statistically significant differences between the two groups in terms of evaluated on admission severity of pancreatitis assessed using APACHE II score and laboratory tests.CT perfusion is a very useful indicator for prediction and selection patients in early stages of acute pancreatitis who are at risk of developing pancreatic and/or peripancreatic

  13. A new method for prediction of the hospitalization period in ICU using neural networks

    Directory of Open Access Journals (Sweden)

    Adel Alinezhad Kolaei

    2013-07-01

    Full Text Available Introduction:APACHE (Acute Physiologic and Chronic Health Evaluation score is a medical tool designed to measure the severity of disease for adult patients admitted to Intensive Care Units (ICU. However, it is designed based on the American patients’ data and is not well suited to be used for Iranian people. In addition, Iranian hospitals are not equipped with High Dependency Units which is required for original APACHE. Method: We aimed to design an intelligent version of APACHE system for recognition of patients’ hospitalization period in ICUs. The new system can be designed based on Iranian local data and updated locally. Intelligence means that the system has the ability to learn from its previous results and doesn’t need manual update. Results: In this study, this new system is introduced and the technical specifications are presented. It is based on neural networks. It can be trained and is capable of auto-learning. The results obtained from final implemented software show better performance than those obtained from non-local version. Conclusion: Using this method, the efficiency of the prediction has increased from 80% to 90%. Such results were compared with the APACHE outputs to show the superiority of the proposed method.

  14. Predictive Value of Nuclear Factor κB Activity and Plasma Cytokine Levels in Patients with Sepsis

    Science.gov (United States)

    Arnalich, Francisco; Garcia-Palomero, Esther; López, Julia; Jiménez, Manuel; Madero, Rosario; Renart, Jaime; Vázquez, Juan José; Montiel, Carmen

    2000-01-01

    The relationship between fluctuating cytokine concentrations in plasma and the outcome of sepsis is complex. We postulated that early measurement of the activation of nuclear factor κB (NF-κB), a transcriptional regulatory protein involved in proinflammatory cytokine expression, may help to predict the outcome of sepsis. We determined NF-κB activation in peripheral blood mononuclear cells of 34 patients with severe sepsis (23 survivors and 11 nonsurvivors) and serial concentrations of inflammatory cytokines (interleukin-6, interleukin-1, and tumor necrosis factor) and various endogenous antagonists in plasma. NF-κB activity was significantly higher in nonsurvivors and correlated strongly with the severity of illness (APACHE II score), although neither was related to the cytokine levels. Apart from NF-κB activity, the interleukin-1 receptor antagonist was the only cytokine tested whose level in plasma was of value in predicting mortality by logistic regression analysis. These results underscore the prognostic value of early measurement of NF-κB activity in patients with severe sepsis. PMID:10722586

  15. The novel EuroSCORE II algorithm predicts the hospital mortality of thoracic aortic surgery in 461 consecutive Japanese patients better than both the original additive and logistic EuroSCORE algorithms

    Science.gov (United States)

    Nishida, Takahiro; Sonoda, Hiromichi; Oishi, Yasuhisa; Tanoue, Yoshihisa; Nakashima, Atsuhiro; Shiokawa, Yuichi; Tominaga, Ryuji

    2014-01-01

    OBJECTIVES The European System for Cardiac Operative Risk Evaluation (EuroSCORE) II was developed to improve the overestimation of surgical risk associated with the original (additive and logistic) EuroSCOREs. The purpose of this study was to evaluate the significance of the EuroSCORE II by comparing its performance with that of the original EuroSCOREs in Japanese patients undergoing surgery on the thoracic aorta. METHODS We have calculated the predicted mortalities according to the additive EuroSCORE, logistic EuroSCORE and EuroSCORE II algorithms in 461 patients who underwent surgery on the thoracic aorta during a period of 20 years (1993–2013). RESULTS The actual in-hospital mortality rates in the low- (additive EuroSCORE of 3–6), moderate- (7–11) and high-risk (≥11) groups (followed by overall mortality) were 1.3, 6.2 and 14.4% (7.2% overall), respectively. Among the three different risk groups, the expected mortality rates were 5.5 ± 0.6, 9.1 ± 0.7 and 13.5 ± 0.2% (9.5 ± 0.1% overall) by the additive EuroSCORE algorithm, 5.3 ± 0.1, 16 ± 0.4 and 42.4 ± 1.3% (19.9 ± 0.7% overall) by the logistic EuroSCORE algorithm and 1.6 ± 0.1, 5.2 ± 0.2 and 18.5 ± 1.3% (7.4 ± 0.4% overall) by the EuroSCORE II algorithm, indicating poor prediction (P < 0.0001) of the mortality in the high-risk group, especially by the logistic EuroSCORE. The areas under the receiver operating characteristic curves of the additive EuroSCORE, logistic EuroSCORE and EuroSCORE II algorithms were 0.6937, 0.7169 and 0.7697, respectively. Thus, the mortality expected by the EuroSCORE II more closely matched the actual mortality in all three risk groups. In contrast, the mortality expected by the logistic EuroSCORE overestimated the risks in the moderate- (P = 0.0002) and high-risk (P < 0.0001) patient groups. CONCLUSIONS Although all of the original EuroSCOREs and EuroSCORE II appreciably predicted the surgical mortality for thoracic aortic surgery in Japanese patients, the Euro

  16. Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer

    Directory of Open Access Journals (Sweden)

    Susini T

    2014-11-01

    Full Text Available Tommaso Susini,1 Barbara Berti,1 Carlo Carriero,1 Ketty Tavella,2 Jacopo Nori,3 Ermanno Vanzi,3 Cecilia Molino,1 Mariarosaria Di Tommaso,1 Marco Santini,1 Valeria Saladino,4 Simonetta Bianchi4 1Department of Health Science, Gynecology Section, 2Department of Health Science, Chemotherapy Section, University of Florence, Italy; 3Diagnostic Senology Unit, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; 4Department of Surgery and Translational Medicine, Pathology Unit, University of Florence, Italy Purpose: Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A and transducin-like enhancer of split 3 (TLE3 as predictive markers of response to therapy with anthracyclines and taxanes. Materials and methods: TOP2A and TLE3 protein expressions were evaluated using immunohistochemistry on 28 samples, obtained by core needle biopsy in patients with locally advanced breast carcinoma, subsequently subjected to epirubicin- and paclitaxel-based neoadjuvant chemotherapy. The immunohistochemical staining was correlated with the clinical response measured by the tumor size reduction evaluated by breast magnetic resonance imaging, prior and after chemotherapy, and by pathologic evaluation of the surgical specimen. Results: Neoadjuvant chemotherapy achieved a size reduction in 26/28 tumors (92.9%, with an average percentage decrease of 45.6%. A downstaging was achieved in 71.4% of the cases of locally advanced carcinoma. TOP2A positivity was correlated with a greater reduction in tumor diameter (P=0.06; negative staining for TLE3 was predictive of a better response to neoadjuvant chemotherapy (P=0.07. A higher reduction in tumor diameter (P=0.03 was also found for tumors that were concurrently TLE3-negative and TOP2A

  17. Sequence analysis and structure prediction of type II Pseudomonas sp. USM 4–55 PHA synthase and an insight into its catalytic mechanism

    Directory of Open Access Journals (Sweden)

    Ahmad Khairudin Nurul

    2006-11-01

    Full Text Available Abstract Background Polyhydroxyalkanoates (PHA, are biodegradable polyesters derived from many microorganisms such as the pseudomonads. These polyesters are in great demand especially in the packaging industries, the medical line as well as the paint industries. The enzyme responsible in catalyzing the formation of PHA is PHA synthase. Due to the limited structural information, its functional properties including catalysis are lacking. Therefore, this study seeks to investigate the structural properties as well as its catalytic mechanism by predicting the three-dimensional (3D model of the Type II Pseudomonas sp. USM 4–55 PHA synthase 1 (PhaC1P.sp USM 4–55. Results Sequence analysis demonstrated that PhaC1P.sp USM 4–55 lacked similarity with all known structures in databases. PSI-BLAST and HMM Superfamily analyses demonstrated that this enzyme belongs to the alpha/beta hydrolase fold family. Threading approach revealed that the most suitable template to use was the human gastric lipase (PDB ID: 1HLG. The superimposition of the predicted PhaC1P.sp USM 4–55 model with 1HLG covering 86.2% of the backbone atoms showed an RMSD of 1.15 Å. The catalytic residues comprising of Cys296, Asp451 and His479 were found to be conserved and located adjacent to each other. In addition to this, an extension to the catalytic mechanism was also proposed whereby two tetrahedral intermediates were believed to form during the PHA biosynthesis. These transition state intermediates were further postulated to be stabilized by the formation of oxyanion holes. Based on the sequence analysis and the deduced model, Ser297 was postulated to contribute to the formation of the oxyanion hole. Conclusion The 3D model of the core region of PhaC1P.sp USM 4–55 from residue 267 to residue 484 was developed using computational techniques and the locations of the catalytic residues were identified. Results from this study for the first time highlighted Ser297 potentially

  18. Effects of inorganic electrolyte anions on enrichment of Cu(II) ions with aminated Fe3O4/graphene oxide: Cu(II) speciation prediction and surface charge measurement.

    Science.gov (United States)

    Hu, Xin-jiang; Liu, Yun-guo; Zeng, Guang-ming; Wang, Hui; You, Shao-hong; Hu, Xi; Tan, Xiao-fei; Chen, An-wei; Guo, Fang-ying

    2015-05-01

    The present work evaluated the effects of six inorganic electrolyte anions on Cu(II) removal using aminated Fe3O4/graphene oxide (AMGO) in single- and multi-ion systems. A 2(6-2) fractional factorial design (FFD) was employed for assessing the effects of multiple anions on the adsorption process. The results indicated that the Cu(II) adsorption was strongly dependent on pH and could be significantly affected by inorganic electrolyte anions due to the changes in Cu(II) speciation and surface charge of AMGO. In the single-ion systems, the presence of monovalent anions (Cl(-), ClO4(-), and NO3(-)) slightly increased the Cu(II) adsorption onto AMGO at low pH, while the Cu(II) adsorption was largely enhanced by the presence of SO4(2-), CO3(2-), and HPO4(2-). Based on the estimates of major effects and interactions from FFD, the factorial effects of the six selected species on Cu(II) adsorption in multi-ion system were in the following sequence: HPO4(2-)>CO3(2-)>Cl(-)>SO4(2-)>NO3(-)=ClO4(-), and the combined factors of AD (Cl(-)×SO4(2-)) and EF (Cl(-)×SO4(2-)) had significant effects on Cu(II) removal.

  19. NeuroPigPen: A Scalable Toolkit for Processing Electrophysiological Signal Data in Neuroscience Applications Using Apache Pig.

    Science.gov (United States)

    Sahoo, Satya S; Wei, Annan; Valdez, Joshua; Wang, Li; Zonjy, Bilal; Tatsuoka, Curtis; Loparo, Kenneth A; Lhatoo, Samden D

    2016-01-01

    The recent advances in neurological imaging and sensing technologies have led to rapid increase in the volume, rate of data generation, and variety of neuroscience data. This "neuroscience Big data" represents a significant opportunity for the biomedical research community to design experiments using data with greater timescale, large number of attributes, and statistically significant data size. The results from these new data-driven research techniques can advance our understanding of complex neurological disorders, help model long-term effects of brain injuries, and provide new insights into dynamics of brain networks. However, many existing neuroinformatics data processing and analysis tools were not built to manage large volume of data, which makes it difficult for researchers to effectively leverage this available data to advance their research. We introduce a new toolkit called NeuroPigPen that was developed using Apache Hadoop and Pig data flow language to address the challenges posed by large-scale electrophysiological signal data. NeuroPigPen is a modular toolkit that can process large volumes of electrophysiological signal data, such as Electroencephalogram (EEG), Electrocardiogram (ECG), and blood oxygen levels (SpO2), using a new distributed storage model called Cloudwave Signal Format (CSF) that supports easy partitioning and storage of signal data on commodity hardware. NeuroPigPen was developed with three design principles: (a) Scalability-the ability to efficiently process increasing volumes of data; (b) Adaptability-the toolkit can be deployed across different computing configurations; and (c) Ease of programming-the toolkit can be easily used to compose multi-step data processing pipelines using high-level programming constructs. The NeuroPigPen toolkit was evaluated using 750 GB of electrophysiological signal data over a variety of Hadoop cluster configurations ranging from 3 to 30 Data nodes. The evaluation results demonstrate that the toolkit

  20. Apache Accumulo for developers

    CERN Document Server

    Halldórsson, Guðmundur Jón

    2013-01-01

    The book will have a tutorial-based approach that will show the readers how to start from scratch with building an Accumulo cluster and learning how to monitor the system and implement aspects such as security.This book is great for developers new to Accumulo, who are looking to get a good grounding in how to use Accumulo. It's assumed that you have an understanding of how Hadoop works, both HDFS and the Map/Reduce. No prior knowledge of ZooKeeper is assumed.

  1. Mastering Apache Maven 3

    CERN Document Server

    Siriwardena, Prabath

    2014-01-01

    If you are working with Java or Java EE projects and you want to take full advantage of Maven in designing, executing, and maintaining your build system for optimal developer productivity, then this book is ideal for you. You should be well versed with Maven and its basic functionality if you wish to get the most out of the book.

  2. Learning Apache Mahout classification

    CERN Document Server

    Gupta, Ashish

    2015-01-01

    If you are a data scientist who has some experience with the Hadoop ecosystem and machine learning methods and want to try out classification on large datasets using Mahout, this book is ideal for you. Knowledge of Java is essential.

  3. Learning Apache Mahout

    CERN Document Server

    Tiwary, Chandramani

    2015-01-01

    If you are a Java developer and want to use Mahout and machine learning to solve Big Data Analytics use cases then this book is for you. Familiarity with shell scripts is assumed but no prior experience is required.

  4. Apache Maven dependency management

    CERN Document Server

    Lalou, Jonathan

    2013-01-01

    An easy-to-follow, tutorial-based guide with chapters progressing from basic to advanced dependency management.If you are working with Java or Java EE projects and you want to take advantage of Maven dependency management, then this book is ideal for you. This book is also particularly useful if you are a developer or an architect. You should be well versed with Maven and its basic functionalities if you wish to get the most out of this book.

  5. Apache Solr PHP integration

    CERN Document Server

    Kumar, Jayant

    2013-01-01

    This book is full of step-by-step example-oriented tutorials which will show readers how to integrate Solr in PHP applications using the available libraries, and boost the inherent search facilities that Solr offers.If you are a developer who knows PHP and is interested in integrating search into your applications, this is the book for you. No advanced knowledge of Solr is required. Very basic knowledge of system commands and the command-line interface on both Linux and Windows is required. You should also be familiar with the concept of Web servers.

  6. Learning Apache Cassandra

    CERN Document Server

    Brown, Mat

    2015-01-01

    If you're an application developer familiar with SQL databases such as MySQL or Postgres, and you want to explore distributed databases such as Cassandra, this is the perfect guide for you. Even if you've never worked with a distributed database before, Cassandra's intuitive programming interface coupled with the step-by-step examples in this book will have you building highly scalable persistence layers for your applications in no time.

  7. Apache hive essentials

    CERN Document Server

    Du, Dayong

    2015-01-01

    If you are a data analyst, developer, or simply someone who wants to use Hive to explore and analyze data in Hadoop, this is the book for you. Whether you are new to big data or an expert, with this book, you will be able to master both the basic and the advanced features of Hive. Since Hive is an SQL-like language, some previous experience with the SQL language and databases is useful to have a better understanding of this book.

  8. Sweet sour gas solution : a win-win Apache Canada plan sweeps an acid gas problem underground, reduces harmful emissions and boosts production

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.

    2004-08-01

    This article discusses the experiences of Apache Canada Ltd. in their efforts to cut costs and deal with environmental problems at their oil and gas field in northwest Alberta. Yields were low and the hydrocarbons sour, containing hydrogen sulphide and carbon dioxide. Some of the hydrogen sulphide is used to produce elemental sulphur (at the expense of releasing large amounts of greenhouse gas) and the rest has to be sequestered. Low sulphur prices have worsened the problem. The solution has been to inject both of the evolved gases into the ground where the hydrogen sulphide acts as a solvent forcing the oil downwards through the rock to a recovery well. The solvent acts to free the oil trapped in the rock. In this way Apache plans to produce more oil from its depleted deposits and sequester the hydrogen sulphide and carbon dioxide it produces anyway. It plans to stop the production of elemental sulphur since it is no longer economically viable. The end of sulphur production, and having gases sequestered in the oil extraction scheme mean that far fewer greenhouse gases are emitted to the atmosphere. 1 ref., 3 figs.

  9. An Investigation of Methods to Measure and Predict Biological and Physical Effects of Commercial Navigation Traffic: Workshop II Held in St. Louis, Missouri on 17-18 April 1990

    Science.gov (United States)

    1991-04-01

    Biolog- ical Effects of Vessel Passage - Mr. Gene Buglewicz, LMV 1500-1530 Break 1530-1545 Panel Discussion II: Strategies for Predicting Biological...for expert testimony as it does for most of life. Care taken to define the limits of a problem pays large dividends in Cime and resources saved later...Wildlife Service Gail Peterson, US Fish and Wildlife Service Joseph Harber, Dan McGuiness and Associates, Wabasha, MN Gene Hollenstein, Minnesota

  10. National Centers for Environmental Prediction-Department of Energy (NCEP-DOE) Atmospheric Model Intercomparison Project (AMIP)-II Reanalysis (Reanalysis-2)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NCEP-DOE Atmospheric Model Intercomparison Project (AMIP-II) reanalysis is a follow-on project to the "50-year" (1948-present) NCEP-NCAR Reanalysis Project....

  11. Value of Different Scoring Methods for Surgical Risk Assessment of Patients with Gastrointestinal Malignancies%不同评分方法对胃肠恶性肿瘤病人手术风险评估的价值

    Institute of Scientific and Technical Information of China (English)

    刘文明; 严想元

    2015-01-01

    目的:比较APACHE APACHE Ⅱ 评分与POSSUM评分对胃肠恶性肿瘤患者手术风险评估的价值.方法:100例胃肠恶性肿瘤患者,术前1d、术后1d分别用APACHE APACHE Ⅱ 评分系统与POSSUM评分系统对患者进行评估,统计患者术后实际并发症发生率及死亡率,计算两种不同评分方法O/E值.结果:术前1d、术后1d APACHE APACHE Ⅱ 评分与POSSUM评分比较差异有统计学意义(P<0.05),APACHE II评分与POSSUM评分之间呈正相关;APACHE APACHE Ⅱ 评分对并发症、死亡发生预测O/E值分别为1.11、0.43,POSSUM评分对并发症、死亡发生预测O/E值分别为0.94、0.72.结论:POSSUM评分相对APACHE APACHE Ⅱ 评分,在胃肠恶性肿瘤患者手术风险(并发症及死亡率)评估上更有优势.%Objective: To compare the value of APACHEAPACHE and POSSUM score in the surgical risk assessment of patients with malignant gastrointestinal tumor.Methods: 100 cases of patients with gastrointestinal tract malignant tumor, 1 day before operation, postoperative 1D, respectively with APACHE APACHE Ⅱ score system and POSSUM scoring system for patients evaluated, statistics of patients with postoperative complications occurred and the mortality rate calculated two different scoring methods O/E values.Results:At 1 day before operation, postoperative 1D APACHE APACHE Ⅱ score and POSSUM scoring, the difference has statistical significance (P<0.05), there was a positive correlation between the APACHE II score and POSSUM scoring; APACHE IAPACHE Ⅱ score of complications and mortality prediction of O/E values were 1.11, 0.43, POSSUM scoring of complications and death prediction of O/E values of 0.94, 0.72, respectively.Conclusions:The POSSUM score relative to the APACHEAPACHE score was more advantageous in the assessment of surgical risks (complications and mortality) in patients with gastrointestinal malignancies.

  12. Myeloperoxidase-Dependent LDL Modifications in Bloodstream Are Mainly Predicted by Angiotensin II, Adiponectin, and Myeloperoxidase Activity: A Cross-Sectional Study in Men

    Directory of Open Access Journals (Sweden)

    Karim Zouaoui Boudjeltia

    2013-01-01

    Full Text Available The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO, an enzyme secreted by neutrophils and macrophages, can modify LDL (Mox-LDL at the surface of endothelial cells. In addition we observed that the activation of the endothelial cells by angiotensin II amplifies this process. We suggested that induction of the NADPH oxidase complex was a major step in the oxidative process. Based on these data, we asked whether there was an independent association, in 121 patients, between NADPH oxidase modulators, such as angiotensin II, adiponectin, and levels of circulating Mox-LDL. Our observations suggest that the combination of blood angiotensin II, MPO activity, and adiponectin explains, at least partially, serum Mox-LDL levels.

  13. Predicting ESR Peaks in Titanium (III, Vanadium (IV and Copper (II Complexes of Halo Ligands by NMR, ESR and NQR Techniques: A DFT Study

    Directory of Open Access Journals (Sweden)

    Harminder Singh

    2015-09-01

    Full Text Available 15 halo (I≥1/2 complexes of Ti (III, V (IV and Cu (II each possessing one unpaired electron were studied using DFT implemented in ADF.2010.02. Aten, NQCC and h parameters of metal ions and ligands were obtained from ESR/EPR program while their σ and δ parameters were given by NMR/EPR program after optimization of complexes. Ligands having same values of these 5 parameters were spatially equivalent and, thus, would undergo same hyperfine interaction. Experimental determination of ESR lines in Cu (II complexes became erroneous because the presence of both the large Jahn-Teller effect and the high value of its spin-orbit coupling constant (λ Cu (II = -830 cm-1 affect the A ten parameter adversely. Cryoscopic conditions, generally required, in ESR experiments of Ti (IIIand V (IVcomplexes were difficult to obtain and cumbersome to maintain.

  14. Towards predictive data-driven simulations of wildfire spread - Part II: Ensemble Kalman Filter for the state estimation of a front-tracking simulator of wildfire spread

    Science.gov (United States)

    Rochoux, M. C.; Emery, C.; Ricci, S.; Cuenot, B.; Trouve, A.

    2015-08-01

    This paper is the second part in a series of two articles, which aims at presenting a data-driven modeling strategy for forecasting wildfire spread scenarios based on the assimilation of the observed fire front location and on the sequential correction of model parameters or model state. This model relies on an estimation of the local rate of fire spread (ROS) as a function of environmental conditions based on Rothermel's semi-empirical formulation, in order to propagate the fire front with an Eulerian front-tracking simulator. In Part I, a data assimilation (DA) system based on an ensemble Kalman filter (EnKF) was implemented to provide a spatially uniform correction of biomass fuel and wind parameters and thereby, produce an improved forecast of the wildfire behavior (addressing uncertainties in the input parameters of the ROS model only). In Part II, the objective of the EnKF algorithm is to sequentially update the two-dimensional coordinates of the markers along the discretized fire front, in order to provide a spatially distributed correction of the fire front location and thereby, a more reliable initial condition for further model time-integration (addressing all sources of uncertainties in the ROS model). The resulting prototype data-driven wildfire spread simulator is first evaluated in a series of verification tests using synthetically generated observations; tests include representative cases with spatially varying biomass properties and temporally varying wind conditions. In order to properly account for uncertainties during the EnKF update step and to accurately represent error correlations along the fireline, it is shown that members of the EnKF ensemble must be generated through variations in estimates of the fire's initial location as well as through variations in the parameters of the ROS model. The performance of the prototype simulator based on state estimation (SE) or parameter estimation (PE) is then evaluated by comparison with data taken from

  15. Community Background Reports: Three Boarding Schools (Phoenix Indian School, Phoenix, Arizona; Theodore Roosevelt School, Fort Apache, Arizona; Chemawa Indian School, Salem, Oregon). National Study of American Indian Education, Series I, No. 15, Final Report.

    Science.gov (United States)

    Wesemann, Ralph E.; And Others

    Three Bureau of Indian Affairs off-reservation boarding schools (Phoenix Indian School in Phoenix, Arizona; Theodore Roosevelt School in Fort Apache, Arizona; and Chemawa Indian School in Salem, Oregon) are the subjects for this report, which is a part of the National Study of American Indian Education. Brief descriptions of the physical plant,…

  16. Neurochemical and structural markers in the brain predicting best choice-of-treatment in patients with schizophrenia - The Pan European Collaboration on Antipsychotic Naïve Schizophrenia II (PECANS II) study

    DEFF Research Database (Denmark)

    Jessen, Kasper; Bojesen, Kirsten Borup; Sigvard, Anne Mette

    as markers for best-choice-of-treatment. Further, the results can pave the way for the development of new antipsychotic medication modulating glutamatergic disturbances and lead to better prevention strategies for the progressive loss of brain tissue and social functions in a treatment resistant subgroup...... the progressive loss of brain tissue and social functions seen in many patients. Aim of PECANS II: To test if persistently high levels of glutamate and loss of brain tissue and social functions characterize a subgroup of patients with poor treatment response, while dopaminergic disturbances characterize another...... subgroup with good treatment response. Materials and methods: PECANS II is a prospective follow-up study of 60 initial antipsychotic naïve patients with schizophrenia and 60 matched healthy controls. Brain levels of glutamate are measured with proton magnetic resonance imaging (1H-MRS), dopaminergic...

  17. Native American embodiment of the chronicities of modernity: reservation food, diabetes, and the metabolic syndrome among the Kiowa, Comanche, and Apache.

    Science.gov (United States)

    Wiedman, Dennis

    2012-12-01

    As a physical embodiment of modernity, the prevalence of obesity, diabetes, and the metabolic syndrome (MetS) among Native Americans reflects their body's biological response to social and cultural structures that routinize daily behaviors and contain their physical body. This article explains why Native Americans were one of the earliest populations manifesting this epidemic. Ethnohistorical methods identify the conjuncture of chronic behaviors among Kiowa, Comanche, and Apache of Oklahoma that promote inactivity, overnutrition, and psychosocial stresses. Correspondence and primary documents of Federal Indian Agents who managed the reservation food rations and annuity systems beginning in the 1860s, details a culture history of nutrition and food technologies that standardized and established the unhealthy modern diet that continues among Native Americans today. By identifying structural chronicities affecting specific populations and life situations, policies and interventions can be more effective in promoting positive changes for reducing the global pandemic of diabetes and MetS. © 2012 by the American Anthropological Association.

  18. Apache cluster in multimedia broadcast content management platform%Apache集群在多媒体内容播控管理平台上的应用*

    Institute of Scientific and Technical Information of China (English)

    张小锋; 朱晓民

    2013-01-01

    随着终端用户的增加,多媒体内容播控管理平台对高访问量、高并发的需求越来越高。本文首先介绍了Apache集群的原理,然后将其应用于多媒体内容播控管理平台中,通过均衡负载,减轻了服务器的负担,提高了响应速度。%With the increasing of the end users, the multimedia broadcast content management platform requires web service with higher speed and better performance. This paper ifrst introduces the principle of the Apache cluster, and then uses the techenique in multimedia broadcast content management platform. Through balancing the load of web servers, it can reduce the burden of server and improve the response speed.

  19. ARDS患者中APACHEⅡ评分及CRP值对呼吸机应用的指导意义%The guide significance of the APACHE Ⅱ score and CRP in acute respiratory distress syndrome to ventilator applications

    Institute of Scientific and Technical Information of China (English)

    杨晓帆; 王君一; 田六九; 黄彩凤; 荣清源; 葛良

    2011-01-01

    Objective: To investigate the guide significance of APACHE Ⅱ score and CRP in acute respiratory distress syndrome to vertilator applications.Methods: Reviewed the 54 ARDS patients from October 2009 to October 2010 that had been freed from ARDS in the ICU of the First People's Hospital of Anqing City, compared the APACHE Ⅱ score and CRP in 55 ARDS before mechanical ventilation with when freed from ventilators, compared the APACHE Ⅱ score and CRP in male ARDS with in the female, and the APACHE Ⅱ score and CRP in ARDS patients with different etiology; at the same time studied the relations between APACHE Ⅱ score and CRP in ARDS patients.Results: The APACHE Ⅱ score and CRP when freed from ventilator were obviously lower than before mechanical ventilation; there was no statistical meaning in the differenee of APACHE Ⅱ score and CRP between male and female; the APACHE Ⅱ acore and CRP in trauma ARDS patients was lower than in pulmonary infection and aspiration ARDS patients without statistical mearung (P>0.05).There was a positive relation between APACHE Ⅱ score and CRP in ARDS patients (r=0 52).Conclusion: There i8 a great guide significance in the applications of mechanical ventilation through studying the change of APACHE Ⅱ score and CRP in ARDS patients.%目的:探讨APACHEⅡ评分及CRP值对ARDS患者呼吸机应用的指导意义.方法:回顾性分析安庆市第一人民医院ICU 2009年10月~2010年10月以来成功救治的55例ARDS患者,比较机械通气前及脱机时APACHEⅡ评分及CRP值,比较不同性别间ARDS患者APACHEⅡ评分及CRP值,比较不同病因间ARDS患者APACHEⅡ评分及CRP值并分析APACHEⅡ评分和CRP值的关联性.结果:脱机时APACHE评分及CRP值较机械通气前显著降低,不同性别间ARDS患者APACHEⅡ评分及CRP值无差异,外伤性ARDS患者机械通气前APACHEⅡ评分及CRP值均较肺部感染及误吸性ARDS高,但差异无统计学意义(P>0.05).ARDS患者APACHEⅡ评分

  20. Ketide Synthase (KS) Domain Prediction and Analysis of Iterative Type II PKS Gene in Marine Sponge-Associated Actinobacteria Producing Biosurfactants and Antimicrobial Agents.

    Science.gov (United States)

    Selvin, Joseph; Sathiyanarayanan, Ganesan; Lipton, Anuj N; Al-Dhabi, Naif Abdullah; Valan Arasu, Mariadhas; Kiran, George S

    2016-01-01

    The important biological macromolecules, such as lipopeptide and glycolipid biosurfactant producing marine actinobacteria were analyzed and their potential linkage between type II polyketide synthase (PKS) genes was explored. A unique feature of type II PKS genes is their high amino acid (AA) sequence homology and conserved gene organization. These enzymes mediate the biosynthesis of polyketide natural products with enormous structural complexity and chemical nature by combinatorial use of various domains. Therefore, deciphering the order of AA sequence encoded by PKS domains tailored the chemical structure of polyketide analogs still remains a great challenge. The present work deals with an in vitro and in silico analysis of PKS type II genes from five actinobacterial species to correlate KS domain architecture and structural features. Our present analysis reveals the unique protein domain organization of iterative type II PKS and KS domain of marine actinobacteria. The findings of this study would have implications in metabolic pathway reconstruction and design of semi-synthetic genomes to achieve rational design of novel natural products.

  1. Ketide Synthase (KS domain prediction and analysis of iterative type II PKS gene in marine sponge-associated actinobacteria producing biosurfactants and antimicrobial agents

    Directory of Open Access Journals (Sweden)

    George Seghal Kiran

    2016-02-01

    Full Text Available The important biological macromolecules such as lipopeptide and glycolipid biosurfactant producing marine actinobacteria were analyzed and their potential linkage between type II polyketide synthase (PKS genes was also explored. A unique feature of type II PKS genes is their high amino acid sequence homology and conserved gene organization. These enzymes mediate the biosynthesis of polyketide natural products with enormous structural complexity and chemical nature by combinatorial use of various domains. Therefore, deciphering the order of amino acid sequence encoded by PKS domains tailored the chemical structure of polyketide analogues still remains a great challenge. The present work deals with an in vitro and in silico analysis of PKS type II genes from five actinobacterial species with known PKS and metabolic products to correlate the domain architecture and structural features shared with known PKS proteins. Our present analysis reveals the unique protein domain organization of iterative type II PKS and KS domain of marine actinobacteria. The findings of this study would have implications in metabolic pathway reconstruction and design of semi-synthetic genomes to achieve rational design of novel natural products.

  2. Serum YKL-40 Predicts Relapse-Free and Overall Survival in Patients With American Joint Committee on Cancer Stage I and II Melanoma

    DEFF Research Database (Denmark)

    Schmidt, Henrik; Johansen, Julia S; Sjoegren, Pia;

    2006-01-01

    PURPOSE: To evaluate the novel tumor biomarker YKL-40 in serial serum samples from patients with American Joint Committee on Cancer (AJCC) stage I and II melanoma from the time of diagnosis and during routine follow-up. Macrophages, neutrophils, and cancer cells secrete YKL-40, and a high serum...

  3. Prediction of Supersonic Store Separation Characteristics Including Fuselage and Stores of Noncircular Cross Section, Volume IV. Appendices C and D, Details of Program II.

    Science.gov (United States)

    1980-11-01

    VOLUME IV - APPENDICES C AND D, DETAILS OF PROGRAM II Joseph Mullen, Jr. Frederick K. Goodwin Marnix F. E. Dillenius Nielsen Engineering & Research...location in store source panel coordinates of leading edge of wing, feet RAZ semi-axis in vertical direction of elliptic body, feet RBY semi-axis in

  4. Comparison of QSAR models based on combinations of genetic algorithm, stepwise multiple linear regression, and artificial neural network methods to predict Kd of some derivatives of aromatic sulfonamides as carbonic anhydrase II inhibitors.

    Science.gov (United States)

    Maleki, Afshin; Daraei, Hiua; Alaei, Loghman; Faraji, Aram

    2014-01-01

    Four stepwise multiple linear regressions (SMLR) and a genetic algorithm (GA) based multiple linear regressions (MLR), together with artificial neural network (ANN) models, were applied for quantitative structure-activity relationship (QSAR) modeling of dissociation constants (Kd) of 62 arylsulfonamide (ArSA) derivatives as human carbonic anhydrase II (HCA II) inhibitors. The best subsets of molecular descriptors were selected by SMLR and GA-MLR methods. These selected variables were used to generate MLR and ANN models. The predictability power of models was examined by an external test set and cross validation. In addition, some tests were done to examine other aspects of the models. The results show that for certain purposes GA-MLR is better than SMLR and for others, ANN overcomes MLR models.

  5. In silico calculated affinity of FVIII-derived peptides for HLA class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 gene.

    Science.gov (United States)

    Pashov, A D; Calvez, T; Gilardin, L; Maillère, B; Repessé, Y; Oldenburg, J; Pavlova, A; Kaveri, S V; Lacroix-Desmazes, S

    2014-03-01

    Forty per cent of haemophilia A (HA) patients have missense mutations in the F8 gene. Yet, all patients with identical mutations are not at the same risk of developing factor VIII (FVIII) inhibitors. In severe HA patients, human leucocyte antigen (HLA) haplotype was identified as a risk factor for onset of FVIII inhibitors. We hypothesized that missense mutations in endogenous FVIII alter the affinity of the mutated peptides for HLA class II, thus skewing FVIII-specific T-cell tolerance and increasing the risk that the corresponding wild-type FVIII-derived peptides induce an anti-FVIII immune response during replacement therapy. Here, we investigated whether affinity for HLA class II of wild-type FVIII-derived peptides that correspond to missense mutations described in the Haemophilia A Mutation, Structure, Test and Resource database is associated with inhibitor development. We predicted the mean affinity for 10 major HLA class II alleles of wild-type FVIII-derived peptides that corresponded to 1456 reported cases of missense mutations. Linear regression analysis confirmed a significant association between the predicted mean peptide affinity and the mutation inhibitory status (P = 0.006). Significance was lost after adjustment on mutation position on FVIII domains. Although analysis of the A1-A2-A3-C1 domains yielded a positive correlation between predicted HLA-binding affinity and inhibitory status (OR = 0.29 [95% CI: 0.14-0.60] for the high affinity tertile, P = 0.002), the C2 domain-restricted analysis indicated an inverse correlation (OR = 3.56 [1.10-11.52], P = 0.03). Our data validate the importance of the affinity of FVIII peptides for HLA alleles to the immunogenicity of therapeutic FVIII in patients with missense mutations. © 2013 John Wiley & Sons Ltd.

  6. The ability of electrical measurements to predict skin moisturization. II. Correlation between one-hour measurements and long-term results

    National Research Council Canada - National Science Library

    Li, F; Conroy, E; Visscher, M; Wickett, R R

    2001-01-01

    We investigated the ability of short-term (one-hour) electrical measurements with three different commonly used instruments to predict the effects of long-term treatment with glycerin-containing formulations on moderately dry leg skin...

  7. Metal Abundance Calibration of the Ca II Triplet Lines in RR Lyrae Stars

    CERN Document Server

    Wallerstein, George; Huang, Wenjin

    2011-01-01

    The GAIA satellite is likely to observe thousands of RR Lyrae stars within a small spectral window, between 8470A and 8750A, at a resolution of 11,500. In order to derive the metallicity of RR Lyrae stars from Gaia, we have obtained numerous spectra of RR Lyrae stars at a resolution of 35,000 with the Apache Point Observatory 3.5 m echelle spectrograph. We have correlated the Ca II triplet line strengths with metallicity as derived from Fe II abundances, analogous to Preston's (1959) use of the Ca II K line to estimate the metallicity of RR Lyrae stars. The Ca II line at 8498A is the least blended with neighboring Paschen lines and thus provides the best correlation.

  8. NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ

    DEFF Research Database (Denmark)

    Karosiene, Edita; Rasmussen, Michael; Blicher, Thomas;

    2013-01-01

    importance for understanding the nature of immune responses and identifying T cell epitopes for the design of new vaccines and immunotherapies. Given the large number of MHC variants, and the costly experimental procedures needed to evaluate individual peptide–MHC interactions, computational predictions have...

  9. The [Fe/H] Dependence on the Ca {\\sc ii}-$M_V$ Relationship

    CERN Document Server

    Gomez, Thomas; Pancino, Elena

    2012-01-01

    We examined the Wilson-Bappu effect, a relationship between the absolute magnitude of the star, $M_V$, and the logarithm of the Ca {\\sc ii} emission width, $W_0$, over the largest $M_V$ range to date, +13 to -5, covering M-dwarfs to type Ia supergiants. We used an extensive literature, the latest Hipparcos reduction, data from two globular clusters, and new observations from Apache Point Observatory to compile a sample that allowed us to study the effect of [Fe/H] on the Wilson-Bappu relationship. Our results include reporting the deviations from linearity and demonstrating that the Wilson-Bappu relationship is insensitive to metallicity.

  10. Basic Diagnosis and Prediction of Persistent Contrail Occurrence using High-resolution Numerical Weather Analyses/Forecasts and Logistic Regression. Part II: Evaluation of Sample Models

    Science.gov (United States)

    Duda, David P.; Minnis, Patrick

    2009-01-01

    Previous studies have shown that probabilistic forecasting may be a useful method for predicting persistent contrail formation. A probabilistic forecast to accurately predict contrail formation over the contiguous United States (CONUS) is created by using meteorological data based on hourly meteorological analyses from the Advanced Regional Prediction System (ARPS) and from the Rapid Update Cycle (RUC) as well as GOES water vapor channel measurements, combined with surface and satellite observations of contrails. Two groups of logistic models were created. The first group of models (SURFACE models) is based on surface-based contrail observations supplemented with satellite observations of contrail occurrence. The second group of models (OUTBREAK models) is derived from a selected subgroup of satellite-based observations of widespread persistent contrails. The mean accuracies for both the SURFACE and OUTBREAK models typically exceeded 75 percent when based on the RUC or ARPS analysis data, but decreased when the logistic models were derived from ARPS forecast data.

  11. Prediction of Six-Degree-of-Freedom Store Separation Trajectories at Speeds up to the Critical Speed. Volume II. Users Manual for the Computer Programs

    Science.gov (United States)

    1974-10-01

    NUMSTR( J ) store number; different for each store and < 99 NSHAPE(J) shape number of store; < 99 SLTHC(J) length of store, feet SRMAX(J) maximum radius...chord leading edge immediately above store, feet; positive below SIC( J ) store incidence angle measured relative to wing root i chord...the j store th 192 Table II-8 Concluded, SXL(K,J) XLEL(I) XSNC(J) XSNI(J) XWSOI(J) Yd) YWSO(J) YSN(J) ZLEL(I) ZSN(J) ZWSO(J) array

  12. Incremental Validity of WISC-IV[superscript UK] Factor Index Scores with a Referred Irish Sample: Predicting Performance on the WIAT-II[superscript UK

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.; James, Trevor; Good, Rebecca; James, Kate

    2014-01-01

    Background: Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. Aims: This study examined the incremental validity of Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004a, "Wechsler Intelligence Scale for Children-Fourth UK…

  13. Incremental Validity of WISC-IV[superscript UK] Factor Index Scores with a Referred Irish Sample: Predicting Performance on the WIAT-II[superscript UK

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.; James, Trevor; Good, Rebecca; James, Kate

    2014-01-01

    Background: Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. Aims: This study examined the incremental validity of Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004a, "Wechsler Intelligence Scale for Children-Fourth UK…

  14. Monte carlo simulation of base and nucleotide excision repair of clustered DNA damage sites. II. Comparisons of model predictions to measured data.

    Science.gov (United States)

    Semenenko, V A; Stewart, R D

    2005-08-01

    Clustered damage sites other than double-strand breaks (DSBs) have the potential to contribute to deleterious effects of ionizing radiation, such as cell killing and mutagenesis. In the companion article (Semenenko et al., Radiat. Res. 164, 180-193, 2005), a general Monte Carlo framework to simulate key steps in the base and nucleotide excision repair of DNA damage other than DSBs is proposed. In this article, model predictions are compared to measured data for selected low-and high-LET radiations. The Monte Carlo model reproduces experimental observations for the formation of enzymatic DSBs in Escherichia coli and cells of two Chinese hamster cell lines (V79 and xrs5). Comparisons of model predictions with experimental values for low-LET radiation suggest that an inhibition of DNA backbone incision at the sites of base damage by opposing strand breaks is active over longer distances between the damaged base and the strand break in hamster cells (8 bp) compared to E. coli (3 bp). Model estimates for the induction of point mutations in the human hypoxanthine guanine phosphoribosyl transferase (HPRT) gene by ionizing radiation are of the same order of magnitude as the measured mutation frequencies. Trends in the mutation frequency for low- and high-LET radiation are predicted correctly by the model. The agreement between selected experimental data sets and simulation results provides some confidence in postulated mechanisms for excision repair of DNA damage other than DSBs and suggests that the proposed Monte Carlo scheme is useful for predicting repair outcomes.

  15. High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients

    DEFF Research Database (Denmark)

    Nielsen, Boye Schnack; Jørgensen, Stine; Fog, Jacob Ulrik;

    2011-01-01

    relative to the nuclear density (TBR) obtained using a red nuclear stain. High TBR (and TB) estimates of miR-21 expression correlated significantly with shorter disease-free survival (p = 0.004, HR = 1.28, 95% CI: 1.06-1.55) in the stage II colon cancer patient group, whereas no significant correlation......Approximately 25% of all patients with stage II colorectal cancer will experience recurrent disease and subsequently die within 5 years. MicroRNA-21 (miR-21) is upregulated in several cancer types and has been associated with survival in colon cancer. In the present study we developed a robust......R-21 signal was revealed as a blue chromogenic reaction, predominantly observed in fibroblast-like cells located in the stromal compartment of the tumors. The expression levels were measured using image analysis. The miR-21 signal was determined as the total blue area (TB), or the area fraction...

  16. Analysis of the quench propagation along Nb3Sn Rutherford cables with the THELMA code. Part II: Model predictions and comparison with experimental results

    Science.gov (United States)

    Manfreda, G.; Bellina, F.; Bajas, H.; Perez, J. C.

    2016-12-01

    To improve the technology of the new generation of accelerator magnets, prototypes are being manufactured and tested in several laboratories. In parallel, many numerical analyses are being carried out to predict the magnets behaviour and interpret the experimental results. This paper focuses on the quench propagation velocity, which is a crucial parameter as regards the energy dissipation along the magnet conductor. The THELMA code, originally developed for cable-in-conduit conductors for fusion magnets, has been used to study such quench propagation. To this purpose, new code modules have been added to describe the Rutherford cable geometry, the material non-linear thermal properties and to describe the thermal conduction problem in transient regime. THELMA can describe the Rutherford cable at the strand level, modelling both the electrical and thermal contact resistances between strands and enabling the analysis of the effects of local hot spots and quench heaters. This paper describes the model application to a sample of Short Model Coil tested at CERN: a comparison is made between the experimental results and the model prediction, showing a good agreement. A comparison is also made with the prediction of the most common analytical models, which give large inaccuracies when dealing with low n-index cables like Nb3Sn cables.

  17. Usefulness of Serum Unbound Free Fatty Acid Levels to Predict Death Early in Patients with ST Segment Elevation Myocardial Infarction[From the TIMI II Trial

    Science.gov (United States)

    Huber, Andrew H.; Kampf, J. Patrick; Kwan, Thomas; Zhu, Baolong; Adams, Jesse; Kleinfeld, Alan M.

    2013-01-01

    Circulating total free fatty acids (FFA) are elevated early in myocardial infarction (MI) and are associated with an increase in mortality. We investigated the association of serum unbound free fatty acids (FFAu) levels with mortality,in patients presenting with ST elevation myocardial infarction (STEMI) in the Thrombolysis in Myocardial Infarction (TIMI) II trial.TIMI II enrolled patients within 4 hours of chest pain. Patients were treated with recombinant tissue plasminogen activator within 1 hour of enrollment. The concentration of FFAu was evaluated in serum samplesfrom 1834 patients obtained at baseline, before therapy.FFAu was an independent risk factor for death as early as one day of hospitalization and continued to be an independent risk factor for the more than 3·8 years of follow up. When adjusted for other cardiovascular risk factors FFAu levels in the fourth as compared to the first quartile remained an independent risk factor for death due to MI (hazard ratio, 5.0; 95 % confidence interval, 1.9-13.0), to all cardiac death (hazard ratio, 2.4; confidence interval, 1.3-4.4) and to all cause death (hazard ratio, 1.9, confidence interval, 1.2-3.1).Females were twice as likely to be in the upper two FFAu quartiles and had approximately twice the rate of death as males. In conclusion, increased levels of FFAu are one of the earliest molecular biomarkers of mortality in STEMI and are independent of other risk factors known to affect outcomes in STEMI. PMID:24176067

  18. The Apache Longbow-Hellfire Missile Test at Yuma Proving Ground: Introduction and Problem Formulation for a Multiple Stressor Risk Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Efroymson, Rebecca Ann [ORNL; Peterson, Mark J [ORNL; Jones, Daniel Steven [ORNL; Suter, Glenn [U.S. Environmental Protection Agency

    2008-01-01

    An ecological risk assessment was conducted at Yuma Proving Ground, Arizona, as a demonstration of the Military Ecological Risk Assessment Framework (MERAF). The focus of the assessment was a testing program at Cibola Range, which involved an Apache Longbow helicopter firing Hellfire missiles at moving targets, i.e., M60-A1 tanks. The problem formulation for the assessment included conceptual models for three component activities of the test, helicopter overflight, missile firing, and tracked vehicle movement, and two ecological endpoint entities, woody desert wash communities and desert mule deer (Odocoileus hemionus crooki) populations. An activity-specific risk assessment framework was available to provide guidance for assessing risks associated with aircraft overflights. Key environmental features of the study area include barren desert pavement and tree-lined desert washes. The primary stressors associated with helicopter overflights were sound and the view of the aircraft. The primary stressor associated with Hellfire missile firing was sound. The principal stressor associated with tracked vehicle movement was soil disturbance, and a resulting, secondary stressor was hydrological change. Water loss to washes and wash vegetation was expected to result from increased ponding, infiltrationand/or evaporation associated with disturbances to desert pavement. A plan for estimating integrated risks from the three military activities was included in the problem formulation.

  19. The Tenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-III Apache Point Observatory Galactic Evolution Experiment

    CERN Document Server

    Ahn, Christopher P; Prieto, Carlos Allende; Anders, Friedrich; Anderson, Scott F; Anderton, Timothy; Andrews, Brett H; Aubourg, Éric; Bailey, Stephen; Bastien, Fabienne A; Bautista, Julian E; Beers, Timothy C; Beifiori, Alessandra; Bender, Chad F; Berlind, Andreas A; Beutler, Florian; Bhardwaj, Vaishali; Bird, Jonathan C; Bizyaev, Dmitry; Blake, Cullen H; Blanton, Michael R; Blomqvist, Michael; Bochanski, John J; Bolton, Adam S; Borde, Arnaud; Bovy, Jo; Bradley, Alaina Shelden; Brandt, W N; Brauer, Dorothée; Brinkmann, J; Brownstein, Joel R; Busca, Nicolás G; Carithers, William; Carlberg, Joleen K; Carnero, Aurelio R; Carr, Michael A; Chiappini, Cristina; Chojnowski, S Drew; Chuang, Chia-Hsun; Comparat, Johan; Crepp, Justin R; Cristiani, Stefano; Croft, Rupert A C; Cuesta, Antonio J; Cunha, Katia; da Costa, Luiz N; Dawson, Kyle S; De Lee, Nathan; Dean, Janice D R; Delubac, Timothée; Deshpande, Rohit; Dhital, Saurav; Ealet, Anne; Ebelke, Garrett L; Edmondson, Edward M; Eisenstein, Daniel J; Epstein, Courtney R; Escoffier, Stephanie; Esposito, Massimiliano; Evans, Michael L; Fabbian, D; Fan, Xiaohui; Favole, Ginevra; Castellá, Bruno Femen\\'\\ia; Alvar, Emma Fernández; Feuillet, Diane; Ak, Nurten Filiz; Finley, Hayley; Fleming, Scott W; Font-Ribera, Andreu; Frinchaboy, Peter M; Galbraith-Frew, J G; Garc\\'\\ia-Hernández, D A; Pérez, Ana E Garc\\'\\ia; Ge, Jian; Génova-Santos, R; Gillespie, Bruce A; Girardi, Léo; Hernández, Jonay I González; Gott, J Richard; Gunn, James E; Guo, Hong; Halverson, Samuel; Harding, Paul; Harris, David W; Hasselquist, Sten; Hawley, Suzanne L; Hayden, Michael; Hearty, Frederick R; Ho, Shirley; Hogg, David W; Holtzman, Jon A; Honscheid, Klaus; Huehnerhoff, Joseph; Ivans, Inese I; Jackson, Kelly M; Jiang, Peng; Johnson, Jennifer A; Kirkby, David; Kinemuchi, K; Klaene, Mark A; Kneib, Jean-Paul; Koesterke, Lars; Lan, Ting-Wen; Lang, Dustin; Goff, Jean-Marc Le; Lee, Khee-Gan; Lee, Young Sun; Long, Daniel C; Loomis, Craig P; Lucatello, Sara; Lupton, Robert H; Ma, Bo; Mahadevan, Suvrath; Maia, Marcio A G; Majewski, Steven R; Malanushenko, Elena; Malanushenko, Viktor; Manchado, A; Manera, Marc; Maraston, Claudia; Margala, Daniel; Martell, Sarah L; Masters, Karen L; McBride, Cameron K; McGreer, Ian D; McMahon, Richard G; Ménard, Brice; Mészáros, Sz; Miralda-Escudé, Jordi; Miyatake, Hironao; Montero-Dorta, Antonio D; Montesano, Francesco; More, Surhud; Morrison, Heather L; Muna, Demitri; Munn, Jeffrey A; Myers, Adam D; Nguyen, Duy Cuong; Nichol, Robert C; Nidever, David L; Noterdaeme, Pasquier; Nuza, Sebastián E; O'Connell, Julia E; O'Connell, Robert W; O'Connell, Ross; Olmstead, Matthew D; Oravetz, Daniel J; Owen, Russell; Padmanabhan, Nikhil; Palanque-Delabrouille, Nathalie; Pan, Kaike; Parejko, John K; Pâris, Isabelle; Pepper, Joshua; Percival, Will J; Pérez-Ràfols, Ignasi; Perottoni, Hélio Dotto; Petitjean, Patrick; Pieri, Matthew M; Pinsonneault, M H; Prada, Francisco; Price-Whelan, Adrian M; Raddick, M Jordan; Rahman, Mubdi; Rebolo, Rafael; Reid, Beth A; Richards, Jonathan C; Riffel, Rogério; Robin, Annie C; Rocha-Pinto, H J; Rockosi, Constance M; Roe, Natalie A; Ross, Ashley J; Ross, Nicholas P; Rossi, Graziano; Roy, Arpita; Rubiño-Martin, J A; Sabiu, Cristiano G; Sánchez, Ariel G; Santiago, Basílio; Sayres, Conor; Schiavon, Ricardo P; Schlegel, David J; Schlesinger, Katharine J; Schmidt, Sarah J; Schneider, Donald P; Schultheis, Mathias; Sellgren, Kris; Shen, Yue; Shetrone, Matthew; Shu, Yiping; Simmons, Audrey E; Skrutskie, M F; Slosar, Anže; Smith, Verne V; Snedden, Stephanie A; Sobeck, Jennifer S; Sobreira, Flavia; Stassun, Keivan G; Steinmetz, Matthias; Strauss, Michael A; Streblyanska, Alina; Suzuki, Nao; Swanson, Molly E C; Terrien, Ryan C; Thakar, Aniruddha R; Thomas, Daniel; Thompson, Benjamin A; Tinker, Jeremy L; Tojeiro, Rita; Troup, Nicholas W; Vandenberg, Jan; Magaña, Mariana Vargas; Viel, Matteo; Vogt, Nicole P; Wake, David A; Weaver, Benjamin A; Weinberg, David H; Weiner, Benjamin J; White, Martin; White, Simon D M; Wilson, John C; Wisniewski, John P; Wood-Vasey, W M; Yèche, Christophe; York, Donald G; Zamora, O; Zasowski, Gail; Zehavi, Idit; Zheng, Zheng; Zhu, Guangtun

    2013-01-01

    The Sloan Digital Sky Survey (SDSS) has been in operation since 2000 April. This paper presents the tenth public data release (DR10) from its current incarnation, SDSS-III. This data release includes the first spectroscopic data from the Apache Point Observatory Galaxy Evolution Experiment (APOGEE), along with spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS) taken through 2012 July. The APOGEE instrument is a near-infrared R~22,500 300-fiber spectrograph covering 1.514--1.696 microns. The APOGEE survey is studying the chemical abundances and radial velocities of roughly 100,000 red giant star candidates in the bulge, bar, disk, and halo of the Milky Way. DR10 includes 178,397 spectra of 57,454 stars, each typically observed three or more times, from APOGEE. Derived quantities from these spectra (radial velocities, effective temperatures, surface gravities, and metallicities) are also included.DR10 also roughly doubles the number of BOSS spectra over those included in the ninth data r...

  20. Mesospheric Temperatures over Apache Point Observatory (32°N, 105°W) Derived from Sloan Digital Sky Survey Spectra

    Science.gov (United States)

    Kim, Gawon; Kim, Yong Ha; Lee, Young Sun

    2017-06-01

    We retrieved rotational temperatures from emission lines of the OH airglow (8-3) band in the sky spectra of the Sloan digital sky survey (SDSS) for the period 2000-2014, as part of the astronomical observation project conducted at the Apache Point observatory (32°N, 105°W). The SDSS temperatures show a typical seasonal variation of mesospheric temperature: low in summer and high in winter. We find that the temperatures respond to solar activity by as much as 1.2 K ±0.8 K per 100 solar flux units, which is consistent with other studies in mid-latitude regions. After the seasonal variation and solar response were subtracted, the SDSS temperature is fairly constant over the 15 year period, unlike cooling trends suggested by some studies. This temperature analysis using SDSS spectra is a unique contribution to the global monitoring of climate change because the SDSS project was established for astronomical purposes and is independent from climate studies. The SDSS temperatures are also compared with mesospheric temperatures measured by the microwave limb sounder (MLS) instrument on board the Aura satellite and the differences are discussed.