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Sample records for apa

  1. APA Council Reports.

    Science.gov (United States)

    2016-10-01

    At the fall component meetings of the American Psychiatric Association in Crystal City, Va., September 14-17, 2016, the APA councils heard reports from their components. Following are summaries of the activities of the councils and their components.

  2. Demystifying APA style.

    Science.gov (United States)

    Cuddy, Claudia M

    2002-01-01

    Many nursing schools and health care journals have adopted the Publication Manual of the American Psychological Association (APA stylebook) as their guide to achieve uniformity and consistency in manuscript preparation as well as in usage and writing style. Published in 2001, the fifth edition of the APA stylebook contains 440 pages and can overwhelm someone who tries to use it for the first time. This article delineates main points in the areas of manuscript preparation, reference lists, in-text citations, and style choices.

  3. APA Educational Psychology Handbook

    Science.gov (United States)

    Harris, Karen R., Ed.; Graham, Steve, Ed.; Urdan, Tim, Ed.

    2011-01-01

    The "APA Educational Psychology Handbook" reflects the broad nature of the field today, with state-of-the-science reviews of the diverse critical theories driving research and practice; in-depth investigation of the range of individual differences and cultural/contextual factors that affect student achievement, motivation, and beliefs; and close…

  4. APA Educational Psychology Handbook

    Science.gov (United States)

    Harris, Karen R., Ed.; Graham, Steve, Ed.; Urdan, Tim, Ed.

    2011-01-01

    The "APA Educational Psychology Handbook" reflects the broad nature of the field today, with state-of-the-science reviews of the diverse critical theories driving research and practice; in-depth investigation of the range of individual differences and cultural/contextual factors that affect student achievement, motivation, and beliefs;…

  5. Estilos de referencia APA

    OpenAIRE

    Gomis Selva, Nieves; Delgado Domenech, Beatriz; González García, María; Sánchez Colodrero, Vicente; Jover Mira, Irene; León Antón, María José

    2011-01-01

    El estilo de referencia de la Asociación Psicológica Americana (APA) es el formato más aceptado y comúnmente utilizado por profesionales e investigadores de ciencias sociales, como Psicología, Magisterio, Enfermería, Criminología, Relaciones públicas, entre otras. La adopción de un estilo de referencia compartido facilita la elaboración y redacción de trabajos, así como la comprensión por parte de otros profesionales interesados por disciplinas afines. Por ello, es imprescindible que los futu...

  6. Recognition of psychotherapy effectiveness: the APA resolution.

    Science.gov (United States)

    Campbell, Linda F; Norcross, John C; Vasquez, Melba J T; Kaslow, Nadine J

    2013-03-01

    In August 2012, the American Psychological Association (APA) Council of Representatives voted overwhelmingly to adopt as APA policy a Resolution on the Recognition of Psychotherapy Effectiveness. This invited article traces the origins and intentions of that resolution and its protracted journey through the APA governance labyrinth. We summarize the planned dissemination and projected results of the resolution and identify several lessons learned through the entire process.

  7. Guide to APA-Based Models

    Science.gov (United States)

    Robins, Robert E.; Delisi, Donald P.

    2008-01-01

    In Robins and Delisi (2008), a linear decay model, a new IGE model by Sarpkaya (2006), and a series of APA-Based models were scored using data from three airports. This report is a guide to the APA-based models.

  8. Comprehending APA Style through Manuscript Analysis.

    Science.gov (United States)

    Smith, Gabie E.; Eggleston, Tami J.

    2001-01-01

    Describes an activity designed to enhance undergraduate student comprehension of the American Psychological Association (APA) manual and style where students examined a poorly written paper for errors in relation to the APA guidelines. Reports the results of a study that tested the effectiveness of the activity. (CMK)

  9. Sport and APA: proces of possible diffusion

    Directory of Open Access Journals (Sweden)

    Hana Válková

    2011-03-01

    Full Text Available Relation between Adapted Physical Activity (APA are described in the article. Recent sport professions as so as professions related to sports are formulated. "Coach" profession is defined with more details, the term "sport of persons with disability" is explained, too. On the bases of personal experience the APA domain which every coach can be touched are presented. Events which recent coaches, sports clubs in Czech Republic participated in are added. The basic questions of EUSAPA project are answered: regular sport and APA are blended together. Diffusion of sport and APA can become good platform for inclusion in life span context. Coaches should be informed about basic principles of APA according the level of connection (humanitarian domain - coaches in sports of disabled, the type of sport (relation to general sport and performance level (recreation - top competitive. The topic APA should be included on adequate level in education courses of coaches. The practice in sport activities of people with disability has to be involved.

  10. APA DAN MANA DALAM KALIMAT DEKLARATIF

    Directory of Open Access Journals (Sweden)

    Sri Puji Astuti

    2016-06-01

    Full Text Available Kalimat merupakan salah satu sarana untuk menyampaikan maksud pembicara atau penulis kepada pendengar atau pembaca. Untuk menyampaikan informasi digunakan kalimat deklaratif. Dalam kalimat deklaratif sering ditemui kata apa dan mana serta bentuk turunannya. Bagaimana kehadiran apa dan mana serta bentuk turunannya dalam kalimat deklaratif dibahas dalam makalah ini. Teori yang digunakan untuk menganalisis adalah teori stuktural. Pengumpulan data dilakukan dengan cara menyimak pemakaian bahasa. Dalam analisis data digunakan metode distribusional yaitu metode analisis data yang berupa penghubungan aantarfenomena dalam bahasa tertentu itu sendiri  Adapun teknik yang d.igunakan dalam penelitian ini adalah teknik delisi, substitusi, dan teknik parafrasa. Dari hasil penelitian disimpilkan  bahwa apa dan mana serta bentuk tuturannya jika terdapat dalam kalimat deklaratif bukan merupakan interogativa. Kehadiran apa dan mana serta bentuk tuturannya dalam kalimat deklaratif ada yang bersifat wajib ada yang bersifat opsional. Apa dan mana serta bentuk turunannya  bersifat opsional jika dalam kalimat deklaratif apa dan mana serta bentuk tuturannya diikuti atau didahului oleh kata yang mempunyai makna yang sama

  11. Resolving a Conflict between APA Learning Goals and APA Ethical Principles

    Science.gov (United States)

    Corty, Eric W.

    2008-01-01

    Although American Psychological Association (APA) Ethical Standards make it clear that instructors cannot require students to disclose personal information in class-related activities, an APA learning goal for undergraduate psychology students is that they reflect on their experiences to develop insight into their behavior and mental processes.…

  12. Aplicaciones Normas APA y sus tendencias

    OpenAIRE

    Ledesma Ayora, Marco; Muñoz Cajilima, Néstor Xavier

    2016-01-01

    [ES] Este manual fue elaborado en base a las normas APA (American Psychological Association), actualización y el aporte como tendencias, el anhelo es que sea de beneficio para estudiantes, docentes e investigadores que aplican una buena escritura académica. Las normas APA es un conjunto de referencias para la escritura de trabajos, proyectos y publicaciones, proyectando así su validez y confiabilidad, que permiten visibilizar una correcta formalidad en la presentación, pudiendo ser mediado a ...

  13. Who Cares about APA Policy and Does it Have an Impact? 2006 Annual Report of the APA Policy and Planning Board

    Science.gov (United States)

    American Psychologist, 2007

    2007-01-01

    What constitutes American Psychological Association (APA) policy? How does it affect the everyday and professional lives of APA members? How personally aware are psychologists of APA policies? In this report, the APA explores these questions and provide some intriguing findings on the fate of policies developed through the APA's complicated and…

  14. The APA Style Converter: a Web-based interface for converting articles to APA style for publication.

    Science.gov (United States)

    Li, Ping; Cunningham, Krystal

    2005-05-01

    The APA Style Converter is a Web-based tool with which authors may prepare their articles in APA style according to the APA Publication Manual (5th ed.). The Converter provides a user-friendly interface that allows authors to copy and paste text and upload figures through the Web, and it automatically converts all texts, references, and figures to a structured article in APA style. The output is saved in PDF or RTF format, ready for either electronic submission or hardcopy printing.

  15. APA, Meet Google: Graduate Students' Approaches to Learning Citation Style

    Science.gov (United States)

    Van Note Chism, Nancy; Weerakoon, Shrinika

    2012-01-01

    Inspired by Perkins' Theories of Difficulty concept, this exploratory study examined the learning patterns of graduate students as they grappled with using the style sheet of the American Psychological Association (APA). The researchers employed task performance analysis of three APA formatting tasks, interviews, and observation during a "think…

  16. Citar e referenciar : APA 6ª ed.

    OpenAIRE

    Marcos, Isabel Marques

    2016-01-01

    A elaboração correta dos trabalhos científicos pressupõe o respeito por um conjunto de princípios normativos de citação e referenciação bibliográfica que salvaguardam os autores das criações intelectuais do uso indevido das mesmas. Partindo de três conceitos: citação, referência bibliográfica e lista de referências apresentam-se as normas da APA 6ª ed. nos seus elementos essenciais. Estas normas, da área da informação e documentação, definem regras para a normalização das referências bibliogr...

  17. Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2016-11-01

    The Edwin B. Newman Graduate Research Award is sponsored jointly by Psi Chi, the national honor society in psychology, and the APA. The award is presented annually to the psychology graduate student who submits the best research paper that was published or presented at a national, regional, or state psychological association conference during the past calendar year. The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. Members of the 2016 Edwin B. Newman Award Committee were Shawn Carlton, PhD, Psi Chi representative; Christina Frederick-Recascino, PhD; John Norcross, PhD, APA representative; Karenna Malavanti, PhD, Psi Chi representative; Steven Kohn, PhD, Psi Chi representative; Warren Fass, PhD, Psi Chi representative; Chris Lovelace, PhD, Psi Chi representative; and Cathy Epkins, PhD, APA representative. (PsycINFO Database Record

  18. 77 FR 38378 - Hours of Service (HOS) of Drivers; Revision of Exemption; American Pyrotechnics Association (APA)

    Science.gov (United States)

    2012-06-27

    ... Exemption; American Pyrotechnics Association (APA) AGENCY: Federal Motor Carrier Safety Administration... the list of member motor carriers of the American Pyrotechnics Association (APA) that were granted an... covered renewal of 53 APA-member motor carriers and added 9 new APA-member carriers. It allowed drivers...

  19. Instructional Strategies to Improve College Students' APA Style Writing

    Science.gov (United States)

    Mandernach, B. Jean; Zafonte, Maria; Taylor, Caroline

    2016-01-01

    The purpose of this study was to identify areas of APA formatting that college instructors view as most problematic in student writing. Using a Likert-style survey, the greatest areas of reported concern were problems with documentation, specifically, citations, references, and quoting; of lesser concern were various style and formatting errors in…

  20. Teaching APA Style Documentation: Discovery Learning, Scaffolding and Procedural Knowledge

    Science.gov (United States)

    Skeen, Thomas; Zafonte, Maria

    2015-01-01

    Students struggle with learning correct documentation style as found in the Publication Manual of the American Psychological Association and teachers are often at a loss for how to best instruct students in correct usage of APA style. As such, the first part of this paper discusses the current research on teaching documentation styles as well as…

  1. Psychodiagnostic Testing in APA-Approved Clinical Psychology Programs.

    Science.gov (United States)

    Piotrowski, Chris; Keller, John W.

    The utility and popularity of psychodiagnostic testing has been investigated in applied clinical settings, but little data exist concerning academicians' attitudes toward psychological testing. To assess attitudes toward psychodiagnostic training in doctoral, clinical psychology programs, all fully APA-approved (American Psychological Association)…

  2. 76 FR 30232 - Hours of Service (HOS) of Drivers; Application of American Pyrotechnics Association (APA) for...

    Science.gov (United States)

    2011-05-24

    ... Pyrotechnics Association (APA) for Exemption From the 14-Hour Rule During Independence Day Celebrations AGENCY...; request for comments. SUMMARY: The American Pyrotechnics Association (APA) has applied for a limited... designated APA-member motor carriers in conjunction with staging fireworks shows celebrating Independence...

  3. The APA and the rise of pediatric generalist network research.

    Science.gov (United States)

    Wasserman, Richard; Serwint, Janet R; Kuppermann, Nathan; Srivastava, Rajendu; Dreyer, Benard

    2011-01-01

    The Academic Pediatric Association (APA, formerly the Ambulatory Pediatric Association) first encouraged multi-institutional collaborative research among its members over 30 years ago. Individual APA members subsequently went on to figure prominently in establishing formal research networks. These enduring collaborations have been established to conduct investigations in a variety of generalist contexts. At present, 4 generalist networks--Pediatric Research in Office Settings (PROS), the Pediatric Emergency Care Applied Research Network (PECARN), the COntinuity Research NETwork (CORNET), and Pediatric Research in Inpatient Settings (PRIS)--have a track record of extensive achievement in generating new knowledge aimed at improving the health and health care of children. This review details the history, accomplishments, and future directions of these networks and summarizes the common themes, strengths, challenges, and opportunities inherent in pediatric generalist network research.

  4. A Better Affine Projection Algorithm (APA) Using Adaptive Gain (AG)%自适应增益APA-AG算法的研究

    Institute of Scientific and Technical Information of China (English)

    智永锋; 范蟠果; 张骏; 邓正宏; 张怡

    2011-01-01

    为了提高自适应滤波器的收敛性和跟踪性,提出了一种自适应增益APA-AG算法.通过分析估计输出误差信号,获得了参数迭代步长的一个特定值估计,以实现集平均代价函数最小化.仿真结果表明,相比较于传统的APA算法,文中研究的APA-AG算法具有更快的收敛速率和更好的跟踪特性.%Aim. To improve the convergence rate and tracking performance of an adaptive filter, especially for the highly colored input signals, Refs. 3 and 4 adopt the APA algorithm. However, its gain does not change, and thus its convergence is not as rapid as is possible, in our opinion, with adaptive gain. We explain mathematically in sections 1, 2 and 3 of the full paper our APA-AG algorithm and discuss how to minimize the ensemble-average cost function by analyzing the estimated output-error. The core of section 2, which is entitled the estimated output-error analysis of the APA algorithm, is that we derive eq. (23). The core of section 3, which is entitled APA-AG algorithm, is that, to minimize the ensemble-average cost function, we obtain the estimated iterated step-sizes of our APA-AG algorithm; the needed equations are eqs. (23), (3c), (28), (27), (26) and (30). Section 4 presents two numerical examples to simulate our APA-AG algorithm; the simulation results, shown in Figs. 1 and 2,and their analysis indicate preliminarily that our APA-AG algorithm has faster convergence rate and better tracking performance compared with the conventional APA algorithm.

  5. Guide för referenshantering : APA-manual inom Barn- och ungdomsvetenskap (BUVA)

    OpenAIRE

    Engdahl, Ingrid

    2014-01-01

    Denna guide behandlar först hur du enligt APA refererar i löpande text och därefter hur man skriver en referenslista. För en komplett guide till APA Style hänvisas till Publication Manual of the American Psychological Association (American Psychological Association, 2010) eller till hemsidan http://www.apastyle.org, där det finns tydlig introduktion i ljud och bild till APA Style.

  6. Recovery from Multiple APAs Delays Gait Initiation in Parkinson’s Disease

    Science.gov (United States)

    Cohen, Rajal G.; Nutt, John G.; Horak, Fay B.

    2017-01-01

    Background: Freezing of gait in Parkinson’s disease (PD) has been linked with deficits in inhibitory control, but causal mechanisms are not established. Freezing at gait initiation (start hesitation) is often accompanied by multiple anticipatory postural adjustments (APAs). If inhibition deficits contribute to freezing by interfering with ability to inhibit initial weight shifts in the wrong direction, then PD subjects should experience more episodes of multiple APAs than healthy controls (HCs) do. If inhibition deficits contribute to freezing by interfering with ability to release a previously inhibited step following multiple APAs, then step onset following multiple APAs should be delayed more in people with PD than in HCs. Methods: Older adults with PD and HC subjects rapidly initiated stepping in response to a light cue in blocks of simple (SRT) and choice (CRT) conditions. We recorded kinematics and ground reaction forces, and we administered the Stroop task to assess inhibitory control. Results: Multiple APAs were more common in CRT than SRT conditions but were equally common in HC and PD subjects. Step onsets were delayed in both conditions and further delayed in trials with multiple APAs, except for HC subjects in SRT trials. Poor Stroop performance correlated with many multiple APAs, late step onset, and rearward position of center of mass (COM) at cue presentation. Forward motion of the COM during the APA was higher in trials with multiple APAs than in trials with single APAs, especially in CRT trials and in PD subjects without self-reported freezing. Conclusion: Start hesitation is not caused by multiple APAs per se, but may be associated with difficulty recovering from multiple APAs, due to difficulty releasing a previously inhibited step. PMID:28261073

  7. Apa is a trimeric autotransporter adhesin of Actinobacillus pleuropneumoniae responsible for autoagglutination and host cell adherence.

    Science.gov (United States)

    Xiao, Longwen; Zhou, Liang; Sun, Changjiang; Feng, Xin; Du, ChongTao; Gao, Yu; Ji, Qun; Yang, Shuxin; Wang, Yu; Han, Wenyu; Langford, P R; Lei, Liancheng

    2012-10-01

    Actinobacillus pleuropneumoniae is the causative agent of porcine pleuropneumonia, and adherence to host cells is a key step in the pathogenic process. Although trimeric autotransporter adhesins (TAAs) were identified in many pathogenic bacteria in recent years, none in A. pleuropneumoniae have been characterized. In this study, we identified a TAA from A. pleuropneumoniae, Apa, and characterized the contribution of its amino acid residues to the adhesion process. Sequence analysis of the C-terminal amino acid residues of Apa revealed the presence of a putative translocator domain and six conserved HsfBD1-like or HsfBD2-like binding domains. Western blot analysis revealed that the 126 C-terminal amino acids of Apa could form trimeric molecules. By confocal laser scanning microscopy, one of these six domains (ApaBD3) was determined to mediate adherence to epithelial cells. Adherence assays and adherence inhibition assays using a recombinant E. coli- ApaBD3 strain which expressed ApaBD3 on the surface of E. coli confirmed that this domain was responsible for the adhesion activity. Moreover, cellular enzyme-linked immunosorbent assays demonstrated that ApaBD3 mediated high-level adherence to epithelial cell lines. Intriguingly, autoagglutination was observed with the E. coli- ApaBD3 strain, and this phenomenon was dependent upon the association of the expressed ApaBD3 with the C-terminal translocator domain.

  8. 抗磷脂抗体(APA)对人和动物生殖的影响%The Effect of Antiphospholipid Antibodies (APA) on Reproduction of Human and Animals

    Institute of Scientific and Technical Information of China (English)

    赫晓燕; 范瑞文

    2003-01-01

    有关研究表明,动物许多自身免疫性疾病或免疫功能异常能够影响妊娠,与自身抗体--抗磷脂抗体( APA)有关.文章就抗磷脂抗体( APA)的种类、性质、作用机制、对人和动物生殖的影响进行了综述.

  9. 76 FR 37880 - Hours of Service (HOS) of Drivers; Granting of Exemption; American Pyrotechnics Association (APA)

    Science.gov (United States)

    2011-06-28

    ...; American Pyrotechnics Association (APA) AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT... decision to grant the application for exemption from the American Pyrotechnics Association (APA) on behalf.... Christine Hydock, FMCSA Driver and Carrier Operations Division, Office of Bus and Truck Standards...

  10. The Impact of APA and AERA Guidelines on Effect Size Reporting

    Science.gov (United States)

    Peng, Chao-Ying Joanne; Chen, Li-Ting; Chiang, Hsu-Min; Chiang, Yi-Chen

    2013-01-01

    Given the long history of effect size (ES) indices (Olejnik and Algina, "Contemporary Educational Psychology," 25, 241-286 2000) and various attempts by APA and AERA to encourage the reporting and interpretation of ES to supplement findings from inferential statistical analyses, it is essential to document the impact of APA and AERA standards on…

  11. Effect of Mixed Solvents and Additives on the Habit Modification of 6-APA Crystals

    Institute of Scientific and Technical Information of China (English)

    GONG Junbo; WANG Jingkang; WEI Hongyuan

    2005-01-01

    6-aminopenicillanic acid (6-APA) crystals obtained under different physical and chemical conditions of the solutions may present different habits. The habits of diamond-shaped plates are desirable compared with other habits of 6-APA crystals. To obtain ideal 6-APA crystals, the effects of the mixed solvents and additives on 6-APA crystal habits were investigated. Ethanol or acetone was used as the organic solvent, and impurities existing in the 6-APA purification process were used as the additives. 6-APA growth habits were changed when the concentrations of ethanol, acetone or phenyl acetic acid were increased to exceed their critical concentration. The observed results show that the dominant face on 6-APA crystals was identified to be {020}, but the overall habit was controlled by the relative growth rates of the {101} and {002} faces. Crystal growth rates and habits can be appreciably changed by specific adsorption of additives on crystal faces.In some cases solvent molecules can act in a similar way and may be regarded as bulk additives. The effects of additives and organic solvents on 6-APA crystal habits were the results of adsorption effect, which fitted the experimental results quite well.

  12. The Language of Scholarship: How to Rapidly Locate and Avoid Common APA Errors.

    Science.gov (United States)

    Freysteinson, Wyona M; Krepper, Rebecca; Mellott, Susan

    2015-10-01

    This article is relevant for nurses and nursing students who are writing scholarly documents for work, school, or publication and who have a basic understanding of American Psychological Association (APA) style. Common APA errors on the reference list and in citations within the text are reviewed. Methods to quickly find and reduce those errors are shared.

  13. Teaching Scientific Writing: Measuring Student Learning in an Intensive APA Skills Course

    Science.gov (United States)

    Luttrell, Vickie R.; Bufkin, Jana L.; Eastman, Valerie J.; Miller, Robin

    2010-01-01

    The "Publication Manual of the American Psychological Association" (American Psychological Association [APA], 2010) provides a widely utilized template for preparing research reports in the behavioral sciences. Because learning APA style is integral to disciplinary socialization, our department recently implemented a 1-hr course in scientific…

  14. Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue.

    Science.gov (United States)

    Coddeville, Bernadette; Wu, Sz-Wei; Fabre, Emeline; Brassart, Colette; Rombouts, Yoann; Burguière, Adeline; Kremer, Laurent; Khoo, Kay-Hooi; Elass-Rochard, Elisabeth; Guérardel, Yann

    2012-10-22

    The 45/47 kDa Apa, an immuno-dominant antigen secreted by Mycobacterium tuberculosis is O-mannosylated at multiple sites. Glycosylation of Apa plays a key role in colonization and invasion of the host cells by M. tuberculosis through interactions of Apa with the host immune system C-type lectins. Mycobacterium marinum (M.ma) a fish pathogen, phylogenetically close to M. tuberculosis, induces a granulomatous response with features similar to those described for M. tuberculosis in human. Although M.ma possesses an Apa homologue, its glycosylation status is unknown, and whether this represents a crucial element in the pathophysiology induced by M.ma remains to be addressed. To this aim, we have identified two concanavalin A-reactive 45/47 kDa proteins from M.ma, which have been further purified by a two-step anion exchange chromatography process. Advanced liquid chromatography-nanoESI mass spectrometry-based proteomic analyses of peptides, derived from either tryptic digestion alone or in combination with the Asp-N endoproteinase, established that M.ma Apa possesses up to seven distinct O-mannosylated sites with mainly single mannose substitutions, which can be further extended at the Ser/Thr/Pro rich region near the N-terminus. This opens the way to further studies focussing on the involvement and biological functions of Apa O-mannosylation using the M.ma/zebrafish model.

  15. In-vitro analysis of APA microcapsules for oral delivery of live bacterial cells.

    Science.gov (United States)

    Chen, H; Ouyang, W; Jones, M; Haque, T; Lawuyi, B; Prakash, S

    2005-08-01

    Oral administration of microcapsules containing live bacterial cells has potential as an alternative therapy for several diseases. This article evaluates the suitability of the alginate-poly-L-lysine-alginate (APA) microcapsules for oral delivery of live bacterial cells, in-vitro, using a dynamic simulated human gastro-intestinal (GI) model. Results showed that the APA microcapsules were morphologically stable in the simulated stomach conditions, but did not retain their structural integrity after a 3-day exposure in simulated human GI media. The microbial populations of the tested bacterial cells and the activities of the tested enzymes in the simulated human GI suspension were not substantially altered by the presence of the APA microcapsules, suggesting that there were no significant adverse effects of oral administration of the APA microcapsules on the flora of the human gastrointestinal tract. When the APA microcapsules containing Lactobacillus plantarum 80 (LP80) were challenged in the simulated gastric medium (pH = 2.0), 80.0% of the encapsulated cells remained viable after a 5-min incubation; however, the viability decreased considerably (8.3%) after 15 min and dropped to 2.6% after 30 min and lower than 0.2% after 60 min, indicating the limitations of the currently obtainable APA membrane for oral delivery of live bacteria. Further in-vivo studies are required before conclusions can be made concerning the inadequacy of APA microcapsules for oral delivery of live bacterial cells.

  16. Biomaterials for the programming of cell growth in oral tissues: The possible role of APA.

    Science.gov (United States)

    Salerno, Marco; Giacomelli, Luca; Larosa, Claudio

    2011-01-06

    Examples of programmed tissue response after the interaction of cells with biomaterials are a hot topic in current dental research. We propose here the use of anodic porous alumina (APA) for the programming of cell growth in oral tissues. In particular, APA may trigger cell growth by the controlled release of specific growth factors and/or ions. Moreover, APA may be used as a scaffold to promote generation of new tissue, due to the high interconnectivity of pores and the high surface roughness displayed by this material.

  17. Nonparametric VSS-APA based on precise background noise power estimate

    Institute of Scientific and Technical Information of China (English)

    昊翔; 赖晓翰; 陈隆道; 蔡忠法

    2015-01-01

    The adaptive algorithm used for echo cancellation (EC) system needs to provide 1) low misadjustment and 2) high convergence rate. The affine projection algorithm (APA) is a better alternative than normalized least mean square (NLMS) algorithm in EC applications where the input signal is highly correlated. Since the APA with a constant step-size has to make compromise between the performance criteria 1) and 2), a variable step-size APA (VSS-APA) provides a more reliable solution. A nonparametric VSS-APA (NPVSS-APA) is proposed by recovering the background noise within the error signal instead of cancelling the a posteriori errors. The most problematic term of its variable step-size formula is the value of background noise power (BNP). The power difference between the desired signal and output signal, which equals the power of error signal statistically, has been considered the BNP estimate in a rough manner. Considering that the error signal consists of background noise and misalignment noise, a precise BNP estimate is achieved by multiplying the rough estimate with a corrective factor. After the analysis on the power ratio of misalignment noise to background noise of APA, the corrective factor is formulated depending on the projection order and the latest value of variable step-size. The new algorithm which does not require any a priori knowledge of EC environment has the advantage of easier controllability in practical application. The simulation results in the EC context indicate the accuracy of the proposed BNP estimate and the more effective behavior of the proposed algorithm compared with other versions of APA class.

  18. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  19. Aquatic toxicity and biodegradability of advanced cationic surfactant APA-22 compatible with the aquatic environment.

    Science.gov (United States)

    Yamane, Masayuki; Toyo, Takamasa; Inoue, Katsuhisa; Sakai, Takaya; Kaneko, Youhei; Nishiyama, Naohiro

    2008-01-01

    Cationic surfactant is a chemical substance used in hair conditioner, fabric softener and other household products. By investigating the relationship between the aquatic toxicity and the chemical structures of two types of mono alkyl cationic surfactants, alkyl trimethylammonium salts and alkyl dimethylamine salts, we have found that the C22 alkyl chain length is effective to reduce the toxicity. Besides, we have recognized that the amidopropyl functional group contributes to the enhanced biodegradability by investigating the biodegradation trend of (alkylamidopropyl)dimethylamine salt (alkyl chain length: C18). Based on these findings, we have developed mono alkyl cationic surfactant called APA-22, N-[3-(dimethylamino)propyl]docosanamide salt. APA-22 is formed by the C22 alkyl chain, amidopropyl functional group and di-methyltertiary amine group. We evaluated the aerobic and anaerobic biodegradability of APA-22 by two standard methods (OECD Test Guideline 301B and ECETOC technical document No.28) and found that this substance was degraded rapidly in both conditions. The toxicity to algae, invertebrate and fish of this substance are evaluated by using OECD Test Guideline 201, 202 and 203, respectively. All acute toxicity values are >1 mg/L, which indicates that environmental toxicity of this substance is relatively less toxic to aquatic organism. In addition, we estimated the biodegradation pathway of APA-22 and observed the complete disappearance of APA-22 and its intermediates during the test periods. Based on the environmental data provided above, we concluded that APA22 is more compatible with the aquatic environment compared to other cationic surfactants with mono long alkyl chain.

  20. Adam M. Reid: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2015-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. One of the 2015 award winners is Adam M. Reid, who received this award "for his community service, in which he has integrated the highest standards of professional psychological clinical practice and science." Adam's award citation, biography, and a selected bibliography are presented here.

  1. Comparative study of 6-APA production by free and agar immobilized bacteria in nutrient broth culture.

    Science.gov (United States)

    Dolui, A K; Das, S

    2011-04-01

    In the present study different bacterial samples were isolated from soil of different places of Dibrugarh and screened for biotransformation ability to produce 6-Aminopenicillanic acid. Among ten isolated bacterial samples, three gram positive bacterial samples designated as AKDD-2, AKDD-4 and AKDD-6 showed the production of 6-APA from penicillin G. Assessment of production of 6-APA after incubation in penicillin G (2 mg/ml) by three different samples separately in free and agar immobilization state was done by HPLC analysis. Reusability of immobilized cells was found successful up to 14 days.

  2. APA/APAGS Award for Distinguished Graduate Student in Professional Psychology: Luz Maria Garcini.

    Science.gov (United States)

    2016-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. The 2016 award winners is Luz Maria Garcini, whose commitment to the health and mental health of those recently immigrated has led to research and service that "have greatly benefited the lives of undocumented individuals in the border area of southern California." Garcini's award citation, biography, and a selected bibliography are presented here. (PsycINFO Database Record

  3. Informed Consent and Clinical Research Involving Children and Adolescents: Implications of the Revised APA Ethics Code and HIPAA

    Science.gov (United States)

    Fisher, Celia B.

    2004-01-01

    In 2003, 2 new sets of rules and regulations affecting the conduct of clinical research involving children and adolescents went into effect: the revised American Psychological Association's (APA) Ethical Principles of Psychologists and Code of Conduct (APA, 2002; effective June 1, 2003) and the Privacy Rule (45 CFR Part 160 and A and E of Part…

  4. APA Reporting Standards in Quantitative Research Dissertations from an Online EdD Program

    Science.gov (United States)

    Salgado, Griselle

    2013-01-01

    This study was an investigation of the reporting practices in dissertations with quantitative research designs produced by students enrolled in an online Doctor of Education (EdD) program, one that follows the American Psychological Association (APA) standards for reporting research. Limited, empirical information exists about the competencies in…

  5. Internship Attainment and Program Policies: Trends in APA-Accredited School Psychology Programs

    Science.gov (United States)

    Perfect, Michelle M.; Thompson, Miriam E.; Mahoney, Emery

    2015-01-01

    Completion of an internship that is accredited by the American Psychological Association (APA) is considered to be to the "gold standard" for health service psychology training programs. The Association of Psychology Postdoctoral and Internship Centers (APPIC) facilitates a Match process between participating applicants and internship…

  6. A Survey of Rorschach Teaching in APA-Approved Clinical Graduate Programs

    Science.gov (United States)

    Del Gaudio, Andrew C.; Ritzler, Barry A.

    1976-01-01

    This survey of APA-approved doctoral programs in clinical psychology provides a status assessment of the Rorschach technique. Eighty-one percent emphasized the technique; a quarter offered the course for a full year; respondents with more experience rated the technique higher; and its was rated highly as a clinical tool and teaching aid, but low…

  7. APA's Learning Objectives for Research Methods and Statistics in Practice: A Multimethod Analysis

    Science.gov (United States)

    Tomcho, Thomas J.; Rice, Diana; Foels, Rob; Folmsbee, Leah; Vladescu, Jason; Lissman, Rachel; Matulewicz, Ryan; Bopp, Kara

    2009-01-01

    Research methods and statistics courses constitute a core undergraduate psychology requirement. We analyzed course syllabi and faculty self-reported coverage of both research methods and statistics course learning objectives to assess the concordance with APA's learning objectives (American Psychological Association, 2007). We obtained a sample of…

  8. Complementing the Latest APA Definition of Hypnosis: Sensory-Motor and Vascular Peculiarities Involved in Hypnotizability.

    Science.gov (United States)

    Santarcangelo, Enrica L; Scattina, Eliana

    2016-01-01

    The aim of this article is to complement the recently revised American Psychological Association (APA) definition of hypnotizability. It (a) lists a few differences in sensorimotor integration between subjects with high (highs) and low (lows) hypnotizability scores in the ordinary state of consciousness and in the absence of suggestions, (b) proposes that hypnotizability-related cerebellar peculiarities may account for them,

  9. Research Productivity and Scholarly Impact of APA-Accredited School Psychology Programs: 2005-2009

    Science.gov (United States)

    Kranzler, John H.; Grapin, Sally L.; Daley, Matt L.

    2011-01-01

    This study examined the research productivity and scholarly impact of faculty in APA-accredited school psychology programs using data in the PsycINFO database from 2005 to 2009. We ranked doctoral programs on the basis of authorship credit, number of publications, and number of citations. In addition, we examined the primary publication outlets of…

  10. Cynthia J. Najdowski: Psi Chi/APA Edwin B. Newman Graduate Research Award

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents a short biography of the winner of the American Psychological Association's Psi Chi/APA Edwin B. Newman Graduate Research Award. The 2012 winner is Cynthia J. Najdowski for an outstanding research paper that examines how jurors' judgments are influenced by a juvenile defendant's confession and status as intellectually disabled. Through…

  11. Scholarly Productivity and Impact of School Psychology Faculty in APA-Accredited Programs

    Science.gov (United States)

    Grapin, Sally L.; Kranzler, John H.; Daley, Matt L.

    2013-01-01

    The primary objective of this study was to conduct a normative assessment of the research productivity and scholarly impact of tenured and tenure-track faculty in school psychology programs accredited by the American Psychological Association (APA). Using the PsycINFO database, productivity and impact were examined for the field as a whole and by…

  12. SY 03-3 OVERVIEW OF SOMATIC MUTATIONS AND EPIGENETIC REGULATION OF ALDOSTERONE PRODUCING ADENOMA (APA).

    Science.gov (United States)

    Umemura, Satoshi

    2016-09-01

    Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension. A unilateral APA is the most common curable cause of hypertension. Early detection of an APA is important both to cure of hypertension by means of adenoma removal and to prevent the onset of resistant hypertension and the risk of long-term cardiovascular complications, such as left ventricular hypertrophy, coronary artery disease, myocardial infarction, heart failure, and atrial fibrillation. (Hypertens 2013; 62: 331)(1) Novel somatic mutations in APARecent advances in genome technology have allowed researchers to unravel part of the genetic abnormalities underlying the development of APA. Pathogenic mechanisms of APA by the somatic mutation are as follows.The majority of the GIRK4 APA mutations (KCNJ5) lie in or within the close proximity of the ion selectivity filter of the K+ channel and result in the indiscriminate conductance of Na+ that causes membrane depolarization, Ca2+ influx, and increased aldosterone biosynthesis.Mutations in the Na+/K+- ATPase 1 (ATP1A1) produce a decrease in K+ binding that results in the reduced import of K+ and export of Na+ and also causes cell depolarization. This in turn results in the opening of voltage- gated Ca2+-channels.In contrast, the Ca2+-ATPase mutations (ATP2B3) were proposed to affect the clearance of cytoplasmic calcium ions. The net result of mutations in both ATPases is therefore likely to cause

  13. Validity and reliability of an IMU-based method to detect APAs prior to gait initiation.

    Science.gov (United States)

    Mancini, Martina; Chiari, Lorenzo; Holmstrom, Lars; Salarian, Arash; Horak, Fay B

    2016-01-01

    Anticipatory postural adjustments (APAs) prior to gait initiation have been largely studied in traditional, laboratory settings using force plates under the feet to characterize the displacement of the center of pressure. However clinical trials and clinical practice would benefit from a portable, inexpensive method for characterizing APAs. Therefore, the main objectives of this study were (1) to develop a novel, automatic IMU-based method to detect and characterize APAs during gait initiation and (2) to measure its test-retest reliability. Experiment I was carried out in the laboratory to determine the validity of the IMU-based method in 10 subjects with PD (OFF medication) and 12 control subjects. Experiment II was carried out in the clinic, to determine test-retest reliability of the IMU-based method in a different set of 17 early-to-moderate, treated subjects with PD (tested ON medication) and 17 age-matched control subjects. Results showed that gait initiation characteristics (both APAs and 1st step) detected with our novel method were significantly correlated to the characteristics calculated with a force plate and motion analysis system. The size of APAs measured with either inertial sensors or force plate was significantly smaller in subjects with PD than in control subjects (p<0.05). Test-retest reliability for the gait initiation characteristics measured with inertial sensors was moderate-to-excellent (0.56

  14. Contribution of seat and foot reaction forces to anticipatory postural adjustments (APAs) in sitting isometric ramp pushes.

    Science.gov (United States)

    Le Bozec, Serge; Bouisset, Simon

    2009-10-01

    The aim of this paper was to examine the role of the upper and lower body on the dynamic phenomena, which precede the voluntary movement (anticipatory postural adjustments: APAs), and the way in which they contribute to postural control. In this view, sitting subjects were asked to perform horizontal two-handed ramp pushes as quickly as possible. A dynamometric bar was used to provide the push force (F(x)). Local reaction forces along the antero-posterior and vertical axes, at the seat and foot-rests (R(Sx), R(Sz), and R(fx), R(fz), respectively), as well as global ones (R(x) and R(z)), were measured. Two postural conditions were considered: full (100 BP) and one-third ischio-femoral contact (30 BP). Anticipatory postural adjustments durations (dAPAs) were measured between the onset of global or local (that is, at the seat and foot level) reaction forces, and the onset of push force increase. Firstly, the dAPAs were longer at the foot than at the seat level, that is, the APA sequence starts at the foot level: it is suggested that a "posturo-focal" sequence is followed, whose progression order is precisely dependent on the postural conditions. Moreover, the APA peak amplitudes (pAPA), measured at the seat contact were significantly greater than the corresponding ones measured at the foot contact: the upper body dynamics are larger than the lower body dynamics. Secondly, a greater peak push force (pF(x)) entailed significant dAPA increases, in preference to pAPA increases. As APAs are dynamic phenomena, they can perturb balance, suggesting that, in order to avoid unnecessary perturbation, APAs are increased in terms of duration rather than amplitude. Lastly, the impulses corresponding to the push force increase ("BPI(x)") and to the APA periods ("ACPI(x)") were calculated. As ACPI(x) was very low as compared to BPI(x), it was suggested that the APA action was limited to the period of the voluntary movement onset.

  15. [Study on relationship of dose-effect and time-effect of APA microencapsulated bovine chromaffin cells on pain treatment].

    Science.gov (United States)

    Hui, Jianfeng; Li, Tao; Du, Zhi; Song, Jichang

    2011-12-01

    This study was to investigate the relationship of dose-effect and time-effect of Alginate-Polylysine-Alginate (APA) microencapsulated bovine chromaffin cells on the treatment of pain model rats. Using a rat model of painful peripheral neuropathy, the antinociceptive effects of APA microencapsulated bovine cells transplanted into the subarachnoid space was evaluated by cold allodynia test and hot hyperalgesia test. Compared with control group, the withdrawal difference with cell number 50 thousands groups, 100 thousands groups and 200 thousands groups was reduced (P APA microencapsulated bovine chromaffin cells which were transplanted to treat pain model rats, and the effective antinociception remained longer than 12 weeks.

  16. cis-Apa: a practical linker for the microwave-assisted preparation of cyclic pseudopeptides via RCM cyclative cleavage.

    Science.gov (United States)

    Baron, Alice; Verdié, Pascal; Martinez, Jean; Lamaty, Frédéric

    2011-02-04

    A new linker cis-5-aminopent-3-enoic acid (cis-Apa) was prepared for the synthesis of cyclic pseudopeptides by cyclization-cleavage by using ring-closing methatesis (RCM). We developed a new synthetic pathway for the preparation of the cis-Apa linker that was tested in the cyclization-cleavage process of different RGD peptide sequences. Different macrocyclic peptidomimetics were prepared by using this integrated microwave-assisted method, showing that the readily available cis-Apa amino acid is well adapted as a linker in the cyclization-cleavage process.

  17. Notable multicultural training in APA-approved counseling psychology and school psychology programs.

    Science.gov (United States)

    Rogers, M R; Hoffman, M A; Wade, J

    1998-01-01

    On the basis of the initial work of M.R. Rogers, J. Martin, and L. Druckman (1994) regarding exemplary multicultural training occurring at school psychology programs, the authors examined salient aspects of 5 American Psychological Association (APA)-approved counseling psychology and 5 APA-approved school psychology programs nominated for their reputation for multicultural training. Twenty-two percent of the program faculty represented a racial-ethnic minority group, at least 2 faculty members per program were involved in multicultural teaching, and 90% of the programs offered a multicultural course. Program faculty at the notable programs were actively involved in relevant research, routinely made presentations at national conferences regarding their scholarship, regularly participated in campuswide multicultural committees, and generally reported their university training environment to be supportive of multicultural issues.

  18. Allie Abrahamson: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2014-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. This year there are joint recipients of the award, Allie Abrahamson and Rebeccah A. Bernard. Their vision, creativity, courage, and dedication led them to create the Human Rights Forum at Chestnut Hill College to promote human rights education, awareness, and community service opportunities for doctoral students. Allie Abrahamson's award citation, biography, and a selected bibliography are presented here.

  19. Jordan M. Braciszewski: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2011-11-01

    Presents Jordan M. Braciszewski as the 2011 winner of the American psychological Association APA/APAGS Award for Distinguished Graduate Student in Professional Psychology. "For his concerted efforts to identify the needs of homeless and other at-risk populations and to design and provide necessary services for them. Jordan M. Braciszewski is committed to using applied psychological science and evidence-based intervention methods to assist the most disadvantaged in our society. He has already provided additions to the relevant research literature and has volunteered countless hours of his time to implement community-based interventions and provide direct services himself. He has sought out the training experiences necessary to assist him in doing an even better job in the future in these public service activities." (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  20. Rebeccah A. Bernard: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2014-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. This year there are joint recipients of the award, Allie Abrahamson and Rebeccah A. Bernard. Their vision, creativity, courage, and dedication led them to create the Human Rights Forum at Chestnut Hill College to promote human rights education, awareness, and community service opportunities for doctoral students. Rebeccah A. Bernard's award citation, biography, and a selected bibliography are presented here.

  1. Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters.

    Science.gov (United States)

    Kurokawa, Masaki; Hideshima, Makoto; Ishii, Yoshiyuki; Kyuwa, Shigeru; Yoshikawa, Yasuhiro

    2009-04-01

    Atherosclerosis is thought to be associated with endoplasmic reticulum (ER) dysfunction and the accumulation of unfolded proteins. In this study, we examined the relationship between atherosclerosis and ER stress and the effect of sodium 4-phenylbutyrate (4-PBA), a kind of chemical chaperone, on atherosclerosis in streptozotocin-induced diabetic APA hamsters. Male, 8-week-old, APA hamsters were injected with streptozotocin (30 mg/kg body weight) to induce diabetes mellitus, and ER stress was evaluated immunohistochemically or by semi-quantitative RT-PCR analysis using ER stress markers such as calreticulin and GPR78. Control hamsters were injected with citrate buffer and were similarly analyzed. In the aorta of control animals, a weak ER stress was detected, and 4-PBA treatment decreased the calreticulin- and GRP78-positive areas and also reduced the mRNA levels of calreticulin and GRP78. On the other hand, strong ER stress was detected at the lesser curvature of the aortic arch of streptozotocin-induced diabetic APA hamsters. However, 4-PBA treatment failed to lessen the ER stress in the aorta and had no effect on improvement of the atherosclerotic lesions. These results may provide an explanation for the complex etiology of atherosclerosis accompanied by diabetes mellitus and various other clinical phenotypes of atherosclerosis.

  2. APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2016-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. The 2016 recipient of the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology was selected by the 2015 Board of Professional Affairs (BPA) and the 2015 APAGS Scholarship and Awards Selection Committee. Members of the 2015 BPA were Patricia Arredondo, EdD; Helen L. Coons, PhD, ABPP; Vickie Mays, PhD, MSPH; Linda A. Reddy, PhD; Lois O. Condi, PhD; Antonette M. Zeiss, PhD; Timothy A. Cavell, PhD; Robert T. Kinscherff, PhD, JD; and Jared L. Skillings, PhD, ABPP. Members of the 2015 APAGS Scholarship and Awards Selection Committee were Emily Voelkel, PhD; Blaire Schembari; and Yolanda Perkins-Volk. (PsycINFO Database Record

  3. Preparation of 6-APA by Enzymatic Bioconversion in an Emulsion Liquid Membrane Reactor

    Institute of Scientific and Technical Information of China (English)

    陆强; 胡鸣; 熊丹柳; 邓修

    2001-01-01

    Production of 6-aminopenicillanic acid (6-APA) by hydrolysis using penicillin acylase (PA) was studied as a model of an enzymatic emulsion liquid membrane (ELM) process. The loss of PA activity was examined for various membrane compositions (organic solvent, surfactant, carrier). The effects of some experimental variables on the stability of emulsion were investigated. It was found that the choice of organic solvent greatly affected tilestability of the emulsion. Increasing the concentration of the carrier in the membrane phase increases the transfer rate of substrate and products but also has a destabilizing effect on the emulsion. The recovery of 6-APA obtained by a di-carrier system (N263-N1923) was much higher than those when either of the di-carriers was used separately.The whole process was controlled both by the enzymatic reaction rate and by the transfer rate of the substrate and the products, however, the ratio of them could be changed by varying the composition of the system. For an optimum condition, it was obtained that the recovery ratio of 6-APA was over 80% and the conversion of benzyl penicillin (PG) was up to 90% in the external phase after 30 minutes. Meanwhile, the breakage percentage of the emulsion was less than 2%.

  4. Isolation of a new restriction enzyme, ApaCI, an isoschizomer of BamHI produced by Acetobacter pasteurianus.

    Science.gov (United States)

    Grones, J; Turna, J

    1992-01-01

    A new Type II restriction endonuclease ApaCI purified from Acetobacter pasteurianus is an isoschizomer of BamHI that cleaves at the nucleotide sequence 5'-G/GATCC-3' of double-stranded DNA. The single restriction activity present in this strain permits rapidly purified 30,000 units of cleavage activity from 10 g of freshly harvested cells. The resulting ApaCI preparation is free of contaminant nuclease activities that might interfere with in vitro manipulation of DNA.

  5. [Use of coulometric titration for elucidating the mechanism of the oxidation of 6-APA alkaline breakdown products by halogens].

    Science.gov (United States)

    Kharlamov, V T; Inkin, A A; Ermolina, G E

    1975-02-01

    Penaldinic acid and penicillamine were formed on alkali decomposition (1 N NaOH) of 6-APA for 20 minutes at room temperature, penicillamine being completely oxidized to disulphide by the air oxygen. Coulometric titration of the alkali decomposition products showed that generated chlorine in 0.5 N HCl solution or bromine in a week acid solution of KBr oxidized them with participation of 7 electrones. Generated iodine did not practically oxidize the 6-APA decomposition products during the coulometric titration.

  6. APA-style human milk fat analogue from silkworm pupae oil: Enzymatic production and improving storage stability using alkyl caffeates.

    Science.gov (United States)

    Liu, Xi; Wang, Xudong; Pang, Na; Zhu, Weijie; Zhao, Xingyu; Wang, Fangqin; Wu, Fuan; Wang, Jun

    2015-12-08

    Silkworm pupae oil derived from reeling waste is a rich source of α-linolenic acid (ALA), which has multipal applications. ALAs were added in sn-1, 3 positions in a triacylglycerol (TAG) to produce an APA-human milk fat analogues (APA-HMFAs, A: α-linolenic acid, P: palmitic acid). The optimum condition is that tripalmitin to free fatty acids of 1:12 (mole ratio) at 65 °C for 48 h using lipase Lipozyme RM IM. Results show that, the major TAG species that comprised APA-HMFAs were rich in ALA and palmitic acid, which contained 64.52% total unsaturated fatty acids (UFAs) and 97.05% PA at the sn-2 position. The melting point of APA was -27.5 °C which is much lower than tripalmitin (40.5 °C) indicating more plastic character. In addition, the practical application of alkyl caffeates as liposoluble antioxidants in APA was developed. Alkyl caffeate showed a superior IC50 (1.25-1.66 μg/mL) compared to butyl hydroxy anisd (1.67 μg/mL) and L-ascorbic acid-6-palmitate (L-AP) (1.87 μg/mL) in DPPH analysis. The addition of ethyl caffeate to oil achieved a higher UFAs content (73.58%) at high temperatures. Overall, APA was obtained from silkworm pupae oil successfully, and the addition of caffeates extended storage ranges for APA-HMFAs.

  7. APA/Psi Chi Edwin B. Newman Graduate Research Award: Meghan H. Puglia.

    Science.gov (United States)

    2016-11-01

    The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). The 2016 recipient is Meghan H. Puglia, who was chosen for "an outstanding foundational research paper that establishes a relationship between a functional epigenetic modification to the oxytocin receptor gene (OXTR) and neural response during social perception." Puglia's award citation, biography, and bibliography are presented here. (PsycINFO Database Record

  8. Connor H. G. Patros: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2015-11-01

    The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). The 2015 recipient is Connor H. G Patros. Patros was chosen for "an excellent research paper that examines the complex relationship between working memory, choice-impulsivity, and the attention-deficit/hyperactivity disorder (ADHD) phenotype." Patros's award citation, biography, and a selected bibliography are presented here.

  9. Unidades de conservação, Legislação ambiental e a APA Petrópolis

    Directory of Open Access Journals (Sweden)

    Julieta Laudelina de Paiva

    2010-12-01

    Full Text Available As unidades de conservação são criadas com o objetivo de manter a diversidade biológica, proteger espécies ameaçadas de extinção, preservar e restaurar ecossistemas naturais. A Área de Proteção Ambiental da Região Serrana de Petrópolis – APA PETRÓPOLIS, primeira APA federal, foi criada por apresentar rica biodiversidade além de ter seus atributos naturais relativamente bem conservados. A população residente na APA Petrópolis está submetida ao cumprimento de várias determinações legais nos três níveis administrativos.

  10. Characterization of the Apa antigen from M. avium subsp. paratuberculosis: a conserved Mycobacterium antigen that elicits a strong humoral response in cattle.

    Science.gov (United States)

    Gioffré, A; Echeverría-Valencia, G; Arese, A; Morsella, C; Garbaccio, S; Delgado, F; Zumárraga, M; Paolicchi, F; Cataldi, A; Romano, M I

    2009-12-15

    Johne's disease or paratuberculosis is widespread in almost all countries and remains difficult to eradicate. Nowadays, diagnosis of Mycobacterium avium subsp. paratuberculosis (MPTB) infection is one of the main concerns. In this work, we evaluated the expression, biochemical properties and antigenicity of the Apa antigen, encoded by the gene annotated as MAP1569, in the MPTB genome. We confirmed its expression in MPTB and its glycosylation by the ConA binding assay. Although the MPTB-Apa is not an immunodominant antigen, MPTB-infected cattle showed a strong humoral response to recombinant Apa by Western blot and ELISA. Milk was also a suitable sample to be tested by ELISA. We comparatively analysed the humoral cross-reactivity to the Apa from MPTB (MPTB-Apa) and the orthologue from Mycobacterium tuberculosis (MT-Apa, identical to that from Mycobacterium bovis) in both infected and control cows. Response of M. bovis- and MPTB-infected animals against MT-Apa was similar (P=0.6985) but the response of the M. bovis-infected ones to MPTB-Apa was differential, being significantly diminished (PApa stimulation in the IFNgamma release assay, we found no significant differences when compared infected herds with non-infected ones (P=0.34). This antigen, in contrast to bovine Purified Protein Derivative (PPDb), was strongly represented in avian PPD (PPDa), as shown by the recognition of BALB/c mice hyperimmune sera against MPTB-Apa by Dot-blot immunoassay. We therefore demonstrated the antigenicity of Apa in MPTB-infected animals and a differential response to the recombinant antigen when compared to M. bovis-infected animals. These traits herein described, added to the usefulness of milk samples to detect IgG anti-Apa, could be important for routine screening in dairy cattle, considering a multiantigenic approach to overcome the lack of immunodominance.

  11. The neuro-mechanical processes that underlie goal-directed medio-lateral APA during gait initiation

    Directory of Open Access Journals (Sweden)

    Jean-Louis HONEINE

    2016-08-01

    Full Text Available Gait initiation involves passing from bipedal to unipedal stance. It requires a rapid movement of the center of foot pressure (CoP towards the future swing foot and of the center of mass (CoM in the direction of the stance foot prior to the incoming step. This anticipatory postural adjustment (APA allows disengaging the swing leg from the ground and establishing favorable conditions for stepping. This study aimed to describe the neuro-mechanical process that underlies the goal-directed medio-lateral APA. We hypothesized that controlled knee flexion of the stance leg contributes to the initial medio-lateral (ML displacement of the CoP and to the calibration of the first step. Nine subjects initiated gait starting from three different initial stance widths of 15 cm (Small, 30 cm (Medium, and 45 cm (Large. Optoelectronic, force platform and EMG measurements were performed. During APA, soleus activity diminished bilaterally, while tibialis anterior activity increased, more so in the stance leg than in the swing leg, and to a larger extent with increasing initial stance width. Knee flexion of the stance leg was observed during APA and correlated with the ML CoP displacement towards the swing leg. ML CoP and CoM displacements during APA increased with increasing stance width. The activity of stance-leg tibialis anterior was correlated with the degree of knee flexion. Swing-leg tensor fasciae latae was also active during APA. Across subjects, when stance-leg tibialis activity was low, tensor fasciae latae activity was large and vice versa. The modulation of the ML CoP position during APA allowed the gravity-driven torque to place the CoM just lateral to the stance foot during step execution. Accordingly, the gravity-driven torque, the ML CoM velocity during step execution, and the step width at foot contact were lower in the Small and greater in the Large condition. Consequently, the position of the stepping foot at foot contact remained close to the

  12. The Neuro-Mechanical Processes That Underlie Goal-Directed Medio-Lateral APA during Gait Initiation

    Science.gov (United States)

    Honeine, Jean-Louis; Schieppati, Marco; Crisafulli, Oscar; Do, Manh-Cuong

    2016-01-01

    Gait initiation (GI) involves passing from bipedal to unipedal stance. It requires a rapid movement of the center of foot pressure (CoP) towards the future swing foot and of the center of mass (CoM) in the direction of the stance foot prior to the incoming step. This anticipatory postural adjustment (APA) allows disengaging the swing leg from the ground and establishing favorable conditions for stepping. This study aimed to describe the neuro-mechanical process that underlies the goal-directed medio-lateral (ML) APA. We hypothesized that controlled knee flexion of the stance leg contributes to the initial ML displacement of the CoP and to the calibration of the first step. Fourteen subjects initiated gait starting from three different initial stance widths of 15 cm (Small), 30 cm (Medium), and 45 cm (Large). Optoelectronic, force platform and electromyogram (EMG) measurements were performed. During APA, soleus activity diminished bilaterally, while tibialis anterior (TA) activity increased, more so in the stance leg than in the swing leg, and to a larger extent with increasing initial stance width. Knee flexion of the stance leg was observed during APA and correlated with the ML CoP displacement towards the swing leg. ML CoP and CoM displacements during APA increased with increasing stance width. The activity of stance-leg TA was correlated with the degree of knee flexion. Swing-leg tensor fasciae latae (TFL) was also active during APA. Across subjects, when stance-leg tibialis activity was low, TFL activity was large and vice versa. The modulation of the ML CoP position during APA allowed the gravity-driven torque to place the CoM just lateral to the stance foot during step execution. Accordingly, the gravity-driven torque, the ML CoM velocity during step execution, and the step width at foot contact (FC) were lower in the Small and greater in the Large condition. Consequently, the position of the stepping foot at FC remained close to the sagittal plane in all

  13. The Neuro-Mechanical Processes That Underlie Goal-Directed Medio-Lateral APA during Gait Initiation.

    Science.gov (United States)

    Honeine, Jean-Louis; Schieppati, Marco; Crisafulli, Oscar; Do, Manh-Cuong

    2016-01-01

    Gait initiation (GI) involves passing from bipedal to unipedal stance. It requires a rapid movement of the center of foot pressure (CoP) towards the future swing foot and of the center of mass (CoM) in the direction of the stance foot prior to the incoming step. This anticipatory postural adjustment (APA) allows disengaging the swing leg from the ground and establishing favorable conditions for stepping. This study aimed to describe the neuro-mechanical process that underlies the goal-directed medio-lateral (ML) APA. We hypothesized that controlled knee flexion of the stance leg contributes to the initial ML displacement of the CoP and to the calibration of the first step. Fourteen subjects initiated gait starting from three different initial stance widths of 15 cm (Small), 30 cm (Medium), and 45 cm (Large). Optoelectronic, force platform and electromyogram (EMG) measurements were performed. During APA, soleus activity diminished bilaterally, while tibialis anterior (TA) activity increased, more so in the stance leg than in the swing leg, and to a larger extent with increasing initial stance width. Knee flexion of the stance leg was observed during APA and correlated with the ML CoP displacement towards the swing leg. ML CoP and CoM displacements during APA increased with increasing stance width. The activity of stance-leg TA was correlated with the degree of knee flexion. Swing-leg tensor fasciae latae (TFL) was also active during APA. Across subjects, when stance-leg tibialis activity was low, TFL activity was large and vice versa. The modulation of the ML CoP position during APA allowed the gravity-driven torque to place the CoM just lateral to the stance foot during step execution. Accordingly, the gravity-driven torque, the ML CoM velocity during step execution, and the step width at foot contact (FC) were lower in the Small and greater in the Large condition. Consequently, the position of the stepping foot at FC remained close to the sagittal plane in all

  14. Are Adolescents Less Mature than Adults?: Minors' Access to Abortion, the Juvenile Death Penalty, and the Alleged APA "Flip-Flop"

    Science.gov (United States)

    Steinberg, Laurence; Cauffman, Elizabeth; Woolard, Jennifer; Graham, Sandra; Banich, Marie

    2009-01-01

    The American Psychological Association's (APA's) stance on the psychological maturity of adolescents has been criticized as inconsistent. In its Supreme Court amicus brief in "Roper v. Simmons" (2005), which abolished the juvenile death penalty, APA described adolescents as developmentally immature. In its amicus brief in "Hodgson v. Minnesota"…

  15. Le B.A.-BA des normes de citation (6ème édition) de l'APA

    OpenAIRE

    Thirion, Paul; Durieux, Nancy

    2012-01-01

    Présentation très synthétique, en une seule page, des principales normes de citation de références bibliographiques de l'American Psychological Association (APA) pour les ouvrages, les chapitres d'ouvrages et les articles.

  16. Advocating for School Psychologists in Response to the APA's Proposed "Model Act for State Licensure of Psychologists"

    Science.gov (United States)

    Skalski, Anastasia Kalamaros

    2009-01-01

    On March 6, 2009, the APA Model Licensure Act Task Force released its second draft of the policy document known as the proposed "Model Act for State Licensure of Psychologists". This policy document serves as guidance to state legislatures for how they should set up their psychology licensing laws. The general expectations promoted in the model…

  17. A Reliable and Valid Weighted Scoring Instrument for Use in Grading APA-Style Empirical Research Report

    Science.gov (United States)

    Greenberg, Kathleen Puglisi

    2012-01-01

    The scoring instrument described in this article is based on a deconstruction of the seven sections of an American Psychological Association (APA)-style empirical research report into a set of learning outcomes divided into content-, expression-, and format-related categories. A double-weighting scheme used to score the report yields a final grade…

  18. Changes in the APA "Publication Manual": How the New Fifth Edition Will Affect Research Reporting in the Social Sciences.

    Science.gov (United States)

    Daniel, Larry G.

    The American Psychological Association (APA) has recently published the fifth edition of its "Publication Manual." This paper provides a brief overview of how this edition differs from previous editions and summarizes features of the new edition that will be likely to have an impact on social science research over the next several years.…

  19. Development of four phylogenetically-arrayed BAC libraries and sequence of the APA locus in Phaseolus vulgaris.

    Science.gov (United States)

    Kami, James; Poncet, Valérie; Geffroy, Valérie; Gepts, Paul

    2006-04-01

    The APA family of seed proteins consists of three subfamilies, in evolutionary order of hypothesized appearance: phytohaemagglutinins (PHA), alpha-amylase inhibitors (alphaAI), and arcelins (ARL). The APA family plays a defensive role against mammalian and insect seed predation in common bean (Phaseolus vulgaris L.). The main locus (APA) for this gene family is situated on linkage group B4. In order to elucidate the pattern of duplication and diversification at this locus, we developed a BAC library in each of four different Phaseolus genotypes that represent presumptive steps in the evolutionary diversification of the APA family. Specifically, BAC libraries were established in one P. lunatus (cv. 'Henderson: PHA+ alphaAI- ARL-) and three P. vulgaris accessions (presumed ancestral wild G21245 from northern Peru: PHA+ alphaAI+ ARL-; Mesoamerican wild G02771: PHA+ alphaAI+ ARL+; and Mesoamerican breeding line BAT93: PHA+ alphaAI+ ARL-). The libraries were constructed after HindIII digestion of high molecular weight DNA, obtained with a novel nuclei isolation procedure. The frequency of empty or cpDNA-sequence-containing clones in all libraries is low (generally APA gene family, including members of the three subfamilies, as hypothesized. The different subfamilies were interspersed with retrotransposon sequences. In addition, other sequences were identified with similarity to chloroplast DNA, a dehydrin gene, and the Arabidopsis flowering D locus. Linkage between the dehydrin gene and the D1711 RFLP marker identifies a potential syntenic region between parts of common bean linkage group B4 and cowpea linkage group 2.

  20. Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis.

    Science.gov (United States)

    Nandakumar, Subhadra; Kannanganat, Sunil; Dobos, Karen M; Lucas, Megan; Spencer, John S; Amara, Rama Rao; Plikaytis, Bonnie B; Posey, James E; Sable, Suraj B

    2016-05-13

    Heterologous prime-boosting has emerged as a powerful vaccination approach against tuberculosis. However, optimal timing to boost BCG-immunity using subunit vaccines remains unclear in clinical trials. Here, we followed the adhesin Apa-specific T-cell responses in BCG-primed mice and investigated its BCG-booster potential. The Apa-specific T-cell response peaked 32-52 weeks after parenteral or mucosal BCG-priming but waned significantly by 78 weeks. A subunit-Apa-boost during the contraction-phase of BCG-response had a greater effect on the magnitude and functional quality of specific cellular and humoral responses compared to a boost at the peak of BCG-response. The cellular response increased following mucosal BCG-prime-Apa-subunit-boost strategy compared to Apa-subunit-prime-BCG-boost approach. However, parenteral BCG-prime-Apa-subunit-boost by a homologous route was the most effective strategy in-terms of enhancing specific T-cell responses during waning in the lung and spleen. Two Apa-boosters markedly improved waning BCG-immunity and significantly reduced Mycobacterium tuberculosis burdens post-challenge. Our results highlight the challenges of optimization of prime-boost regimens in mice where BCG drives persistent immune-activation and suggest that boosting with a heterologous vaccine may be ideal once the specific persisting effector responses are contracted. Our results have important implications for design of prime-boost regimens against tuberculosis in humans.

  1. A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA

    Directory of Open Access Journals (Sweden)

    Anirban Nandi

    2014-01-01

    Full Text Available Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D. In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA. It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.

  2. A Proposal for Six Sigma Integration for Large-Scale Production of Penicillin G and Subsequent Conversion to 6-APA.

    Science.gov (United States)

    Nandi, Anirban; Pan, Sharadwata; Potumarthi, Ravichandra; Danquah, Michael K; Sarethy, Indira P

    2014-01-01

    Six Sigma methodology has been successfully applied to daily operations by several leading global private firms including GE and Motorola, to leverage their net profits. Comparatively, limited studies have been conducted to find out whether this highly successful methodology can be applied to research and development (R&D). In the current study, we have reviewed and proposed a process for a probable integration of Six Sigma methodology to large-scale production of Penicillin G and its subsequent conversion to 6-aminopenicillanic acid (6-APA). It is anticipated that the important aspects of quality control and quality assurance will highly benefit from the integration of Six Sigma methodology in mass production of Penicillin G and/or its conversion to 6-APA.

  3. Sümeyra Tosun: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2014-11-01

    The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). The 2014 recipient is Sümeyra Tosun. Tosun was chosen for "an outstanding research paper that examines the cognitive repercussions of obligatory versus optional marking of evidentiality, the linguistic coding of the source of information. In English, evidentiality is conveyed in the lexicon through the use of adverbs. In Turkish, evidentiality is coded in the grammar. In two experiments, it was found that English speakers were equally good at remembering and monitoring the source of firsthand information and the source of non-firsthand information. Turkish speakers were worse at remembering and monitoring non-firsthand information than firsthand information and were worse than English speakers at remembering and monitoring non-firsthand information." Tosun's award citation, biography, and a selected bibliography are presented here.

  4. Synthesis and properties of ApA analogues with shortened phosphonate internucleotide linkage.

    Science.gov (United States)

    Králíková, Sárka; Buděšínský, Miloš; Barvík, Ivan; Masojídková, Milena; Točík, Zdeněk; Rosenberg, Ivan

    2011-01-01

    A complete series of the 2 '-5 ' and 3 '-5 ' regioisomeric types of r(ApA) and 2 '-d(ApA) analogues with the α-hydroxy-phosphonate C3 '-O-P-CH(OH)-C4 ″ internucleotide linkage, isopolar but non-isosteric with the phosphodiester one, were synthesized and their hybridization properties with polyU studied. Due to the chirality on the 5 '-carbon atom of the modified internucleotide linkage bearing phosphorus and hydroxy moieties, each regioisomeric type of ApA dimer is split into epimeric pairs. To examine the role of the 5 '-hydroxyl of the α-hydroxy-phosphonate moiety during hybridization, the appropriate r(ApA) analogues with 3 '(2 ')-O-P-CH(2)-C4 ″ linkage lacking the 5 '-hydroxyl were synthesized. Nuclear magnetic resonance (NMR) spectroscopy study on the conformation of the modified sugar-phosphate backbone, along with the hybridization measurements, revealed remarkable differences in the stability of complexes with polyU, depending on the 5 '-carbon atom configuration. Potential usefulness of the α-hydroxy-phosphonate linkage in modified oligoribonucleotides is discussed.

  5. QUANTITATIVE STUDY OF STUDENTS FROM CAMPO MOURÃO - PR APAE SCHOLL WITH RELATIVES PORTER OF

    Directory of Open Access Journals (Sweden)

    Michelle Alves Macena Lacerda¹; Ivone Maggione Fiori1

    2007-06-01

    Full Text Available About 25% of the Brazilian population have some kind of deficiency, among them 50% are mental. Brazilian situation isaggravated due to poverty conditions, misery, malnutrition, need of basic sanitation, disinformation, and precarious healthattendance. It is esteem that 350 million people with deficiency are excluded of any kind of medical attendance. For themaintenance of a person that carries a deficiency, 12,452 dollars are spent annually. On the other hand, “per capita” annual costof primary prevention is 20 dollars and of secondary prevention is 600 dollars. Population does not have access to informationabout causes, prevention and deficient child attendance and demonstrates wrong information, superstition and fears about thissubject. Thus, this study aimed to detect factors that may contribute with the improvement of preventive actions. Data obtainedfrom studies carried out with 100 APAE Scholl students in Campo Mourão allowed to analyze some common characteristicsabout them. One of these characteristics was that from all of 100 students under analysis, 52 had relatives with some kind ofmental, sensorial or additive deficiency. According to this index it is possible to conclude that people that have relatives withsome kind of deficiency also have great probabilities of generate children with deficiencies.

  6. 6-APA溶液物理化学特性的测定%Determination of the Physical and Chemical Properties of 6-APA Solutions

    Institute of Scientific and Technical Information of China (English)

    王鹏辉; 马文婵; 曹维峰

    2011-01-01

    6-氨基青霉烷酸(6-APA)是青霉素的母核,是半合成β-内酞胺抗生素生产的重要中间体.本文对于6-APA的溶液物理化学特性进行了分析与测定,其中包括溶解度、密度、粘度数据等,为6-APA工业化设计提供了依据.%6-aminopenicillanic acid (6-APA)is the nucleus of the penicillin molecule and serves as an important intermediate in the production of semisynthetie β-lactam antibiotics. This paper study the crystallization thermodynamic data, such as solubility, metastable zone and other basic data of 6-APA were measured based on experiments, which are useful for design and control of production of 6-APA.

  7. La cita documental : elementos y ejemplos de referencias en los estilos de la MLA y de la APA. Documentos electrónicos ISO 690-2

    OpenAIRE

    Kolesas, Mabel; De-Volder, Carolina

    2008-01-01

    How to quote. Abridged style manual for writers of printed documents according to the Modern Language Association (MLA), the American Psychological Association (APA) and ISO 690-2 standards for E-documents.

  8. Evidence of association of vitamin D receptor Apa I gene polymorphism with bone mineral density in postmenopausal women with osteoporosis.

    Science.gov (United States)

    Dundar, Umit; Solak, Mustafa; Kavuncu, Vural; Ozdemir, Mujgan; Cakir, Tuncay; Yildiz, Handan; Evcik, Deniz

    2009-10-01

    The vitamin D receptor (VDR) was the first candidate gene to be studied in relation to osteoporosis, and most attention has focused on polymorphisms situated near the 3' flank of VDR. The aim of this study was to investigate the association about VDR gene Apa I polymorphism with bone mineral density (BMD) in postmenopausal women with osteoporosis. We studied a total of 136 postmenopausal women with a mean age of 56.36 +/- 10.29 years. Among them, a total of 75 had osteoporosis, 37 had osteopenia, and 24 had normal BMD. Venous blood samples were obtained for evaluation of bone metabolism and genotyping. The VDR Apa I genotype was determined by polymerase chain reaction-restriction fragment length polymorphism. BMDs at the lumbar spine and hip were measured by dual-energy X-ray absorptiometry. Postmenopausal women with aa genotype had significantly lower BMD values (grams per centimeter square) at lumbar spines compared to persons with AA genotype. Also, postmenopausal women with AA genotype had significantly higher serum Ca level than the subjects with aa genotype. In conclusion, our result may indicate that VDR Apa I gene polymorphism may be responsible for a important part of the heritable component of lumbar spine BMD in postmenopausal women, possibly related to impaired calcium absorption from the bowel.

  9. APA guidelines: their importance and a plan to keep them current: 2013 annual report of the Policy and Planning Board.

    Science.gov (United States)

    2014-01-01

    When guidelines are approved by APA, they become association policy, and it is imperative that they remain current. The revision of guidelines poses several challenges to the association. These challenges range from the availability and allocation of resources to support the complicated processes involved in developing and updating these policies to the lack of a clearly defined process that includes identification of tasks, assignments of responsibilities, and so forth. For this reason, the APA Board of Directors asked the Policy and Planning Board (P&P) to work with the boards of the four directorates (i.e., the Education Directorate, the Practice Directorate, the Public Interest Directorate, and the Science Directorate) to create a proposal that would (a) make recommendations with regard to how the review and revision of guidelines documents might best be accomplished in accordance with the APA Strategic Plan and existing policies and procedures and (b) make suggestions regarding the association resources that might be required. The Board of Directors approved the proposed review process in December 2013.

  10. Putative alternative polyadenylation (APA) events in the early interaction of Salmonella enterica Typhimurium and human host cells.

    Science.gov (United States)

    Afonso-Grunz, Fabian

    2015-12-01

    The immune response of epithelial cells upon infection is mediated by changing activity levels of a variety of proteins along with changes in mRNA, and also ncRNA abundance. Alternative polyadenylation (APA) represents a mechanism that diversifies gene expression similar to alternative splicing. T-cell activation, neuronal activity, development and several human diseases including viral infections involve APA, but at present it remains unclear if this mechanism is also implicated in the response to bacterial infections. Our recently published study of interacting Salmonella enterica Typhimurium and human host cells includes genome-wide expression profiles of human epithelial cells prior and subsequent to infection with the invasive pathogen. The generated dataset (GEO accession number: GSE61730) covers several points of time post infection, and one of these interaction stages was additionally profiled with MACE-based dual 3'Seq, which allows for identification of polyadenylation (PA) sites. The present study features the polyadenylation landscape in early interacting cells based on this data, and provides a comparison of the identified PA sites with those of a corresponding 3P-Seq dataset of non-interacting cells. Differential PA site usage of FTL, PRDX1 and VAPA results in transcription of mRNA isoforms with distinct sets of miRNA and protein binding sites that influence processing, localization, stability, and translation of the respective mRNA. APA of these candidate genes consequently harbors the potential to modulate the host cell response to bacterial infection.

  11. Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery: Preparation and in Vitro Characterization.

    Science.gov (United States)

    Tomaro-Duchesneau, Catherine; Saha, Shyamali; Malhotra, Meenakshi; Coussa-Charley, Michael; Kahouli, Imen; Jones, Mitchell L; Labbé, Alain; Prakash, Satya

    2012-02-16

    Probiotics possess potential therapeutic and preventative effects for various diseases and metabolic disorders. One important limitation for the oral delivery of probiotics is the harsh conditions of the upper gastrointestinal tract (GIT) which challenge bacterial viability and activity. One proposed method to surpass this obstacle is the use of microencapsulation to improve the delivery of bacterial cells to the lower GIT. The aim of this study is to use alginate-poly-L-lysine-alginate (APA) microcapsules to encapsulate Lactobacillus fermentum NCIMB 5221 and characterize its enzymatic activity and viability through a simulated GIT. This specific strain, in previous research, was characterized for its inherent ferulic acid esterase (FAE) activity which could prove beneficial in the development of a therapeutic for the treatment and prevention of cancers and metabolic disorders. Our findings demonstrate that the APA microcapsule does not slow the mass transfer of substrate into and that of the FA product out of the microcapsule, while also not impairing bacterial cell viability. The use of simulated gastrointestinal conditions led to a significant 2.5 log difference in viability between the free (1.10 × 104 ± 1.00 × 103 cfu/mL) and the microencapsulated (5.50 × 106 ± 1.00 × 105 cfu/mL) L. fermentum NCIMB 5221 following exposure. The work presented here suggests that APA microencapsulation can be used as an effective oral delivery method for L. fermentum NCIMB 5221, a FAE-active probiotic strain.

  12. Probiotic Ferulic Acid Esterase Active Lactobacillus fermentum NCIMB 5221 APA Microcapsules for Oral Delivery: Preparation and in Vitro Characterization

    Directory of Open Access Journals (Sweden)

    Catherine Tomaro-Duchesneau

    2012-02-01

    Full Text Available Probiotics possess potential therapeutic and preventative effects for various diseases and metabolic disorders. One important limitation for the oral delivery of probiotics is the harsh conditions of the upper gastrointestinal tract (GIT which challenge bacterial viability and activity. One proposed method to surpass this obstacle is the use of microencapsulation to improve the delivery of bacterial cells to the lower GIT. The aim of this study is to use alginate-poly-L-lysine-alginate (APA microcapsules to encapsulate Lactobacillus fermentum NCIMB 5221 and characterize its enzymatic activity and viability through a simulated GIT. This specific strain, in previous research, was characterized for its inherent ferulic acid esterase (FAE activity which could prove beneficial in the development of a therapeutic for the treatment and prevention of cancers and metabolic disorders. Our findings demonstrate that the APA microcapsule does not slow the mass transfer of substrate into and that of the FA product out of the microcapsule, while also not impairing bacterial cell viability. The use of simulated gastrointestinal conditions led to a significant 2.5 log difference in viability between the free (1.10 × 104 ± 1.00 × 103 cfu/mL and the microencapsulated (5.50 × 106 ± 1.00 × 105 cfu/mL L. fermentum NCIMB 5221 following exposure. The work presented here suggests that APA microencapsulation can be used as an effective oral delivery method for L. fermentum NCIMB 5221, a FAE-active probiotic strain.

  13. Performance and model of a full-scale up-flow anaerobic sludge blanket (UASB) to treat the pharmaceutical wastewater containing 6-APA and amoxicillin.

    Science.gov (United States)

    Chen, Zhiqiang; Wang, Hongcheng; Chen, Zhaobo; Ren, Nanqi; Wang, Aijie; Shi, Yue; Li, Xiaoming

    2011-01-30

    A full-scale test was conducted with an up-flow anaerobic sludge blanket (UASB) pre-treating pharmaceutical wastewater containing 6-aminopenicillanic acid (6-APA) and amoxicillin. The aim of the study is to investigate the performance of UASB in the condition of a high chemical oxygen demand (COD) loading rate from 12.57 to 21.02 kgm(-3)d(-1) and a wide pH from 5.57 to 8.26, in order to provide a reference for treating the similar chemical synthetic pharmaceutical wastewater containing 6-APA and amoxicillin. The results demonstrated that the UASB average percentage reduction in COD, 6-APA and amoxicillin were 52.2%, 26.3% and 21.6%, respectively. In addition, three models, built on the back propagation neural network (BPNN) theory and linear regression techniques were developed for the simulation of the UASB system performance in the biodegradation of pharmaceutical wastewater containing 6-APA and amoxicillin. The average error of COD, 6-APA and amoxicillin were -0.63%, 2.19% and 5.40%, respectively. The results indicated that these models built on the BPNN theory were well-fitted to the detected data, and were able to simulate and predict the removal of COD, 6-APA and amoxicillin by UASB.

  14. The role of anticipatory postural adjustments (APAs) in interlimb coordination of coupled arm movements in the parasagittal plane: I. APAs associated with fast discrete flexion and extension movements of one arm or of both arms ISO- and ANTI-directionally coupled.

    Science.gov (United States)

    Esposti, Roberto; Baldissera, Fausto G

    2013-08-01

    Coupling stability during cyclic arm movements in the horizontal (transverse) plane is lower in ISO- than in ANTI-directional coupling. We proposed that such impairment arises from the interference exerted in ISO by the anticipatory postural adjustments (APAs) linked to the primary movements. To evaluate if a link between coupling stability and postural adjustments also exist for arm movements with different postural requirements, we focused on arm(s) flexion-extension in the parasagittal plane and started by analysing the APAs distribution in arm, trunk and leg muscles. Fast flexion and extension of the right arm elicited APAs in the left anterior and posterior deltoid that replicated the excitation-inhibition of the homologous prime movers; this pattern would favour ISO and contrast ANTI-coupled movements. Instead, in the left latissimus dorsi, APAs were opposite to the voluntary actions in the right latissimus dorsi, thus favouring ANTI coupling. Symmetrical APAs were also elicited in right and left erector spinae (RES, LES) and asymmetrical APAs in Ischiocruralis (RIC, LIC), while an antero-posterior force (Fy) and a moment about the vertical axis (Tz) were discharged to the ground. When fast discrete movements were ISO-coupled, APAs were symmetrical in trunk (RES, LES) and leg (RIC, LIC) muscles and a large Fy but no Tz was generated. In ANTI coupling, APAs in RES and LES remained symmetrical, whereas they became antisymmetrical in RIC and LIC. A large Tz and a small Fy were recorded. In conclusion, during parasagittal movements, APAs in are elicited in both ISO and ANTI coupling, at variance with horizontal movements where they are only present in ISO. This would suggest that the difference in coupling stability between the two modes is smaller (or even reversed) in parasagittal with respect to horizontal arm movements.

  15. 我が国の事前確認(APA)の現状と課題 : 事前確認(APA)における納税者のジレンマ <研究ノート>

    OpenAIRE

    虫明, 千春; 佐伯, 健司

    2012-01-01

    移転価格税制の適用に係る問題に対しては,「移転価格事務運営要領」および「事前確認の状況─ APA レポート─」から確認できるとおり,事前確認制度による解決が図られており,特にバイラテラルAPA およびマルチラテラルAPA の利用が強く推奨されている。本研究ノートは,事前確認制度の意義を概観したうえで,納税者の立場から事前確認の利用におけるジレンマを指摘するものである。Givati(2009)の見解における事前確認を利用することによる懸念が,納税者におけるジレンマの一要因となっているものと考える。そのうえで,我が国の事前確認制度の法令による制度化を提言するものである。...

  16. Progress in the associated G-protein-coupled receptors (GPCRs) of aldosterone-producing adenoma (APA) pathogenesis%醛固酮瘤(APA)发病相关的G蛋白耦联受体(GPCRs)研究进展

    Institute of Scientific and Technical Information of China (English)

    徐曦

    2014-01-01

    醛固酮瘤(aldosterone-producing adenoma,APA)是原发性醛固酮增多症的一个重要亚型,约占30%~60%,是引起继发性高血压的重要病因.有关APA的发病机制,可见不同水平与角度的研究,但是对于APA的具体发病机制仍不清楚.本文就已知的与发病相关的G蛋白耦联受体(G-protein-coupled receptors,GPCRs)进行论述.

  17. Carbonatites and primary carbonates in the Rio Apa and Amambay regions, NE Paraguay

    Science.gov (United States)

    Comin-Chiaramonti, Piero; De Min, Angelo; Girardi, Vicente A. V.; Gomes, Celso B.

    2014-02-01

    In the Rio Apa and Amambay regions, north-eastern Paraguay (NPAA), potassic, alkaline-carbonatitic rocks (138-139 Ma) predate the eruption of tholeiitic flood basalts (133 ± 1 Ma). These rocks, mainly outcropping as dykes or ring-like complexes, intrude a Cambro-Ordovician carbonate platform and Precambrian metamorphic rocks along with their Silurian and Permo-Carboniferous sediments. The main rock-types range from basanite to trachyte and trachyphonolite (and intrusive equivalents) to carbonatite, in addition to glimmeritic and pyroxenitic veins. Geological and geophysical evidence indicate that the NPAA magmatism is related to extensional tectonics, like the Early Cretaceous alkaline-carbonatitic complexes from central-eastern Paraguay (127 ± 1 Ma) and the eastern magmatic occurrences of the Paraná Basin. Oxygen and carbon isotope compositions (whole rocks and carbonates) vary from values close to the field of continental lithospheric mantle, or that of primary carbonatites, up to values typical of a hydrothermal environment. An isotope exchange model implies that the main isotope variations, ranging from a magmatic (e.g., 1200 °C) to a low temperature (< 400 °C) environment, involved fluids with CO2/H2O ratios between 0.8 and 1.0. In particular, the Osbnd C isotopic variations, in combination with the La vs La/Yb ratios, suggest an increasingly higher level of carbonate in the silicate liquids, with increasing evolution, i.e., basanite → phonotephrite → trachyphonolite-phonolite (trachyte) → carbonatite. Srsbnd Nd isotopes show that the carbonatites are mantle derived without significant crustal contamination and that they can be related to isotopically enriched sources where newly formed veins (enriched component) and peridotite matrix (depleted component) underwent differing isotopic evolution. TDM model ages for NPAA range from 1.2 to 2.3 Ga. Considering that in the whole Paraná Basin isotopically distinct K-alkaline and tholeiitic magmas were

  18. Pautas para citar textos y hacer listas de referencias según las normas de la American Psichological Association (APA)

    OpenAIRE

    Ossa, Marcela

    2003-01-01

    La escritura de documentos, artículos, ensayos etc. implica seguir cuidadosamente algunas normas. La Revista EMA se guía para la edición de sus artículos por las normas de la American Psychological Association (APA). El presente documento tiene como objeto dar a conocer algunas de estas normas de tal modo que quien envíe un artículo para su publicación las utilice. Encontrarán algunas pautas para citar textos y hacer listas de referencias según las normas de la American Psychological Associat...

  19. 维生素D受体Apa Ⅰ多态性与系统性红斑狼疮的相关性研究%Association of vitamin D receptor gene Apa Ⅰ polymorphism with systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    夏艳辉; 罗雄燕; 武丽君; 杨明辉; 刘宁涛; 库尔班江; 谢传美; 唐中; 曾小峰

    2013-01-01

    Objective To determine the distribution of vitamin D receptor (VDR) gene Apa Ⅰ polymorphism and the possible association with systemic lupus erythematosus (SLE) in Chinese Han population.Methods Genomic DNA from 244 Chinese SLE patients and 162 sex and ethnically matched controls were typed for VDR Apa Ⅰ polymorphism by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).Frequency distribution was compared between patients and the controls using Chi-Square test.Clinical characteristics were analyzed between different Apa Ⅰ genotypes and between alleles using Chi-Square test and analysis of variance.Results There was no significant difference in the distribution frequencies of Apa Ⅰ alleles between SLE patients and the controls,but the distribution frequency of heterozygote Aa in SLE patients was higher than that in the controls (38.9% vs 22.2%,x2=12.442,P=0.000).The relative risk for heterozygote Aa was 2.232(95%CI=1.421-3.503,x2=12.442,P=0.000).No significant difference was observed between SLE patients and the controls with regard to homozygote AA or homozygote aa (P=0.098,P=0.067,respectively).Furthermore,when analyzing the effects of VDR Apa Ⅰ polymorphism on the symptoms of SLE,significant difference was observed,with SLE patients carrying heterozygote Aa developed serositis (P=0.000),and those carrying homozygote AA developed renal disorder (P=0.01) along with the presence of antiDNA antibody (P=0.014).Conclusion There is a significant association between VDR gene heterozygote Aa and the incidence of systemic lupus erythematosus in Han population of China,the heterozygote Aa is also involved in serositis.Although there is no association between homozygote AA and the incidence of systemic lupus erythematosus,homozygote AA is involved in renal disorder and has a positive effect on anti-dsDNA antibody production.%目的 检测维生素D受体(VDR)基因Apa Ⅰ多态性在系统性红斑狼疮(SLE)患者中的分布,并

  20. Calamitic Smectic A-Polar Smectic APA Transition Observed in Bent Molecules with Large Bent-Angle Central Core of 4,6-Dichlorobenzene and Alkylthio Terminal Tail

    Science.gov (United States)

    Nguyen, Ha; Kang, Sungmin; Tokita, Masatoshi; Watanabe, Junji

    2011-07-01

    New homologs of bent molecules with a large bent-angle central core of 4,6-dichloro benzene and an alkylthio terminal tail have been synthesized. Although the corresponding alkoxy-tail homologs show only the calamitic phases because of its large bent angles around 160°, the new homologs with an alkylthio tail exhibit the antiferroelectric smectic APA (SmAPA) banana phase that is transformed on cooling from the calamitic smectic A (SmA) phase. The biaxial polar packing of bent molecules in the SmAPA phase is considered to arise from the hindered rotation around the molecular long axis due to the expansion of the mesophase temperatures to a lower temperature region. This study indicates that the bent molecules, even with a large bent angle, have the potential to form a switchable banana phase with a remarkable decrease in its phase temperature range to around 60 °C.

  1. [Phase transfer catalyzed bioconversion of penicillin G to 6-APA by immobilized penicillin acylase in recyclable aqueous two-phase systems with light/pH sensitive copolymers].

    Science.gov (United States)

    Jin, Ke-ming; Cao, Xue-jun; Su, Jin; Ma, Li; Zhuang, Ying-ping; Chu, Ju; Zhang, Si-liang

    2008-03-01

    Immobilized penicillin acylase was used for bioconversion of penicillin PG into 6-APA in aqueous two-phase systems consisting of a light-sensitive polymer PNBC and a pH-sensitive polymer PADB. Partition coefficients of 6-APA was found to be about 5.78 in the presence of 1% NaCl. Enzyme kinetics showed that the reaction reached equilibrium at roughly 7 h. The 6-APA mole yields were 85.3% (pH 7.8, 20 degrees C), with about 20% increment as compared with the reaction of single aqueous phase buffer. The partition coefficient of PG (Na) varied scarcely, while that of the product, 6-APA and phenylacetic acid (PA) significantly varied due to Donnan effect of the phase systems and hydrophobicity of the products. The variation of the partition coefficients of the products also affected the bioconversion yield of the products. In the aqueous two-phase systems, the substrate, PG, the products of 6-APA and PA were biased in the top phase, while immobilized penicillin acylase at completely partitioned at the bottom. The substrate and PG entered the bottom phase, where it was catalyzed into 6-APA and PA and entered the top phase. Inhibition of the substrate and products was removed to result in improvement of the product yield, and the immobilized enzyme showed higher efficiency than the immobilized cells and occupied smaller volume. Compared with the free enzyme, immobilized enzyme had greater stability, longer life-time, and was completely partitioned in the bottom phase and recycle. Bioconversion in two-phase systems using immobilized penicillin acylase showed outstanding advantage. The light-sensitive copolymer forming aqueous two-phase systems could be recovered by laser radiation at 488 nm or filtered 450 nm light, while pH-sensitive polymer PADB could be recovered at the isoelectric point (pH 4.1). The recovery of the two copolymers was between 95% and 99%.

  2. The O-mannosylation and production of recombinant APA (45/47 KDa protein from Mycobacterium tuberculosis in Streptomyces lividans is affected by culture conditions in shake flasks

    Directory of Open Access Journals (Sweden)

    Gamboa-Suasnavart Ramsés A

    2011-12-01

    Full Text Available Abstract Background The Ala-Pro-rich O-glycoprotein known as the 45/47 kDa or APA antigen from Mycobacterium tuberculosis is an immunodominant adhesin restricted to mycobacterium genus and has been proposed as an alternative candidate to generate a new vaccine against tuberculosis or for diagnosis kits. In this work, the recombinant O-glycoprotein APA was produced by the non-pathogenic filamentous bacteria Streptomyces lividans, evaluating three different culture conditions. This strain is known for its ability to produce heterologous proteins in a shorter time compared to M. tuberculosis. Results Three different shake flask geometries were used to provide different shear and oxygenation conditions; and the impact of those conditions on the morphology of S. lividans and the production of rAPA was characterized and evaluated. Small unbranched free filaments and mycelial clumps were found in baffled and coiled shake flasks, but one order of magnitude larger pellets were found in conventional shake flasks. The production of rAPA is around 3 times higher in small mycelia than in larger pellets, most probably due to difficulties in mass transfer inside pellets. Moreover, there are four putative sites of O-mannosylation in native APA, one of which is located at the carboxy-terminal region. The carbohydrate composition of this site was determined for rAPA by mass spectrometry analysis, and was found to contain different glycoforms depending on culture conditions. Up to two mannoses residues were found in cultures carried out in conventional shake flasks, and up to five mannoses residues were determined in coiled and baffled shake flasks. Conclusions The shear and/or oxygenation parameters determine the bacterial morphology, the productivity, and the O-mannosylation of rAPA in S. lividans. As demonstrated here, culture conditions have to be carefully controlled in order to obtain recombinant O-glycosylated proteins with similar "quality" in bacteria

  3. 婴幼儿佝偻病VDR基因ApaI、BsmI位点多态性与连锁不平衡分析%Study on the association between vitamin D receptor gene polymorphism of ApaI and BsmI and vitamin D deficiency rickets

    Institute of Scientific and Technical Information of China (English)

    周丽; 石永生; 蒋成鹏; 王卫凯; 李宇宁

    2011-01-01

    Objective To study the distribution characters and linkage disequilibrium of vitamin D receptor(VDR) gene ApaI and BsmI polymorphism,and explore the genetic susceptibility of VDR and vitamin D deficiency rickets.Methods VDR gene ApaI and BsmI polymorphisms were determined by PCRRFLP technology in 56 cases of rickets and 76 cases of normal children.The frequencies of the VDR genotype and allele were compared between the two groups.The software SHEsis was used to make linkage disequilibrium analysis.Results No significant difference was found in either the frequency distribution of VDR gene ApaI and BsmI polymorphism or allele of them between two groups; Two polymorphisms didn't show linkage disequilibrium and D' and r2 were 0.23 and 0.01,respectively.Conclusions The ApaI and BsmI polymorphism of VDR gene might be not associated with vitamin D deficiency rickets.Two polymorphisms didn't show linkage disequilibrium.%目的 探讨婴幼儿佝偻病患者维生素D受体(VDR)基因ApaI、BsmI位点多态性分布特征及连锁不平衡关系及其与佝偻病的遗传易感因素.方法 应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对56例佝偻病患儿和76例健康对照儿进行VDR基因ApaI、BsmI位点多态性的检测,分析两组VDR基因型和等位基因频率及两位点间连锁不平衡的关系.结果 两组VDR基因ApaI、BsmI位点基因型频率分布比较差异均无统计学意义(P>0.05).VDR基因ApaI、BsmI 位点等位基因频率在两组人群中的分布差异均无统计学意义(P>0.05).ApaI与BsmI二位点连锁不平衡系(D'=0.230,r2=0.01).结论 VDR基因ApaI、BsmI位点的多态性与维生素D缺乏性佝偻病无明显关系,且两位点不存在连锁不平衡关系.

  4. Vitamin-D receptor (VDR) gene polymorphisms (Taq-I & Apa-I) in Syrian healthy population.

    Science.gov (United States)

    Haddad, Shaden

    2014-12-01

    The vitamin D endocrine system regulates bone metabolism and calcium homeostasis as well as cellular proliferation and differentiation. Vitamin D receptor (VDR) mediates Vit-D activity, thus VDR gene polymorphisms may correlate with different diseases. This study aimed to determine the distribution of VDR gene (Taq-I and Apa-I) polymorphisms using a RFLP in unrelated normal healthy individuals of Syrian population. Allelic frequencies were 65% vs 35% and 66% vs 34% for T vs t and A vs a alleles, respectively. Genotype distribution was 36%, 58% and 6% for TT, Tt and tt and 42%, 47% and 10% for AA, Aa and aa, respectively. These results demonstrate that the frequency and distribution of the VDR polymorphisms in Syrian population are different from other populations worldwide.

  5. Training in psychodiagnostic testing in APA-approved PsyD and PhD clinical psychology programs.

    Science.gov (United States)

    Piotrowski, C; Zalewski, C

    1993-10-01

    Fifty-one percent (N = 80) of directors of doctoral PhD and PsyD programs in clinical psychology, accredited by the American Psychological Association (APA), responded to a survey on assessment training. The study was a replication of an earlier survey by Piotrowski and Keller (1984b) on instruction, practices, and attitudes on testing. Our findings indicated that training emphasis in assessment coursework has changed very little over the past decade. Intelligence testing was emphasized in most programs, followed by objective and projective personality assessment. However, training in behavioral assessment techniques was required in only half of the responding programs. There were no significant differences between PhD and PsyD programs concerning required coursework in assessment. Factors that influence the perennial importance of testing in the clinical core curriculum are discussed.

  6. 智能泊车辅助系统(APA)研究%Research on Advanced Parking Aid (APA)

    Institute of Scientific and Technical Information of China (English)

    郭鑫; 韩延明; 白永; 程斌

    2016-01-01

    With the rapid growth of China's economy and the vigorous development of the auto industry, urban motorize-tion level increased significantly, in the motor vehicle to flourish, result in series of city traffic problem increasingly prominent, the phenomenon of "less parking spaces, parking hard" is serious, so pay close attention to urban parking problems, has become an important and urgent work. In this paper, we study the advanced parking aid system which is through ultrasonic radar automatically detect the object around the vehicle, through digital signal processing and intelligent algorithm for calculating the length and width information of current parking space, and by automatically turn the steering wheel and HMI operation to adjust vehicle body angle, control vehicles are driven in accordance with the best parking track line, make the driver parking easily, safely, and fast. This paper introduces the APA system architecture, system using conditions, and the calculation method of the parking space size and the parking track line, through the above content, completely introduce the APA system implementation scheme.%随着我国经济的快速增长以及汽车产业的蓬勃发展,城市中的机动化水平显著提高,机动车数量剧增,随之出现的一系列城市交通问题逐渐突出,其中“车位少,停车难”现象严重,因此关注城市停车问题,已经成为一项重要而紧急的工作。  文章研究的智能泊车辅助系统(APA)是通过超声波雷达自动侦测车辆附近的障碍物,使用数字信号处理及智能算法获取当前停车位的长度和宽度信息,通过自动转动方向盘调节车身角度和人机界面操作控制车辆按照最佳的泊车轨迹行驶,使驾驶员轻松,安全,快速的完成泊车入位。  文章着重介绍 APA 系统架构、系统使用条件、车位大小计算方法,泊车轨迹等内容,阐述完整的 APA 系统实现方案。

  7. TaqI, FokI, and ApaI Polymorphisms in the Vitamin D Receptor in Behçet’s Disease in Turkish Population

    Directory of Open Access Journals (Sweden)

    Gaye Erten

    2016-01-01

    Full Text Available Objectives. In our study we aimed to determine VDR gene polymorphisms in patients with Behçet’s disease (BD and neuro-Behçet’s disease (NBD in Turkish population. Methods. PBL obtained from 37 patients with BD, 21 patients with NB, and 30 healthy controls were investigated. Genomic DNA was extracted from whole blood using the QIAamp Blood Kit. VDR ApaI (rs7975232, VDR FokI (rs2228570, and VDR TaqI (rs731236 genotyping was performed by real-time polymerase chain reaction with SimpleProbe melting-curve analysis. Results. The allelic and genotype distributions of FokI and TaqI polymorphisms were not different among Behçet’s disease, neuro-Behçet’s disease, and control subjects in Turkish population (p>0.05. Only the frequency of ApaI A allele in control is higher than that in BD (60% versus 38.5%, and the p value is 0.014, but the power is not enough to conclude that ApaI A allele is protective in BD in our study. Taken together, we found no significant differences between the BD, NBD, and control groups regarding the distribution of ApaI, TaqI, and FokI genotype and alleles frequencies. Conclusions. Future studies with larger patients’ numbers may show differences between VDR polymorphisms and Behçet’s disease.

  8. Association of insulin-like growth factor 2 Apa1 A820G gene (rs680 polymorphism with polycystic ovarian syndrome

    Directory of Open Access Journals (Sweden)

    Sujatha Thathapudi

    2016-08-01

    Conclusions: This study suggests that IGF 2 gene Apa1 A820G polymorphism is associated with PCOS and could be used as a relevant molecular marker to identify women with risk of developing PCOS in our population and may provide an understanding about the etiology of PCOS. [Int J Reprod Contracept Obstet Gynecol 2016; 5(8.000: 2618-2623

  9. Biologic effect and immunoisolating behavior of BMP-2 gene-transfected bone marrow-derived mesenchymal stem cells in APA microcapsules.

    Science.gov (United States)

    Ding, H F; Liu, R; Li, B G; Lou, J R; Dai, K R; Tang, T T

    2007-11-03

    We investigated the encapsulation of BMP-2 gene-modified mesenchymal stem cells (MSCs) in alginate-poly-L-lysine (APA) microcapsules for the persistent delivery of bone morphogenic protein-2 (BMP-2) to induce bone formation. An electrostatic droplet generator was employed to produce APA microcapsules containing encapsulated beta-gal or BMP-2 gene-transfected bone marrow-derived MSCs. We found that X-gal staining was still positive 28 days after encapsulation. Encapsulated BMP-2 gene-transfected cells were capable of constitutive delivery of BMP-2 proteins for at least 30 days. The encapsulated BMP-2 gene-transfected MSCs or the encapsulated non-gene transfer MSCs (control group) were cocultured with the undifferentiated MSCs. The gene products from the encapsulated BMP-2 cells could induce the undifferentiated MSCs to become osteoblasts that had higher alkaline phosphatase (ALP) activity than those in the control group (pAPA microcapsules could inhibit the permeation of fluorescein isothiocyanate-conjuncted immunoglobulin G. Mixed lymphocyte reaction also indicates that the APA microcapsules could prevent the encapsulated BMP-2 gene-transfected MSCs from initiating the cellular immune response. These results demonstrated that the nonautologous BMP-2 gene-transfected stem cells are of potential utility for enhancement of bone repair and bone regeneration in vivo.

  10. Evolutionary analysis of the APA genes in the Phaseolus genus: wild and cultivated bean species as sources of lectin-related resistance factors?

    Science.gov (United States)

    Lioi, L; Galasso, I; Lanave, C; Daminati, M G; Bollini, R; Sparvoli, F

    2007-11-01

    The APA (Arcelin/Phytohemagglutinin/alpha-Amylase inhibitor) gene family is composed of various members, present in Phaseolus species and coding for lectin and lectin-related seed proteins having the double role of storage and defense proteins. Here members of the APA family have been identified by immunological, functional, and molecular analyses and representative genes were sequenced in nine wild species of Phaseolus. All taxa possessed at least one member of the true lectin gene. No arcelin type sequences have been isolated from the species examined. Among the wild species studied, only P. costaricensis contained an alpha-amylase inhibitor (alpha-AI). In addition P. augusti, P. maculatus, P. microcarpus, and P. oligospermus showed the presence of the lectin-related alpha-amylase inhibitor-like (AIL) genes and alpha-AI activity. Data from Southern blot analysis indicated the presence of only one lectin gene in P. parvulus and P. filiformis, while an extensive gene duplication of the APA locus was found in the other Phaseolus species. Phylogenetic analysis carried out on the nucleotide sequences showed the existence of two main clusters and clearly indicated that lectin-related genes originated from a paralogous duplication event preceding the development of the ancestor to the Phaseolus genus. The finding of detectable alpha-AI activity in species containing AIL genes suggests that exploiting APA genes variability in the Phaseolus genus may represent a valuable tool to find new members that may have acquired insecticidal activities.

  11. The Adh adhesin domain is required for trimeric autotransporter Apa1-mediated Actinobacillus pleuropneumoniae adhesion, autoaggregation, biofilm formation and pathogenicity.

    Science.gov (United States)

    Wang, Lei; Qin, Wanhai; Yang, Shuxin; Zhai, Ruidong; Zhou, Liang; Sun, Changjiang; Pan, Fengguang; Ji, Qun; Wang, Yu; Gu, Jingmin; Feng, Xin; Du, Chongtao; Han, Wenyu; Langford, P R; Lei, Liancheng

    2015-05-15

    Actinobacillus pleuropneumoniae is a causative agent of porcine pleuropneumonia, which is a highly contagious endemic disease of pigs. Adhesion is a critical first step in the infection process. Trimeric autotransporter adhesions (TAAs) have been identified as novel virulence factors; however, little is known on their roles in A. pleuropneumoniae pathogenicity. Here, our data show that YadA-like head region (Adh) of Apa1 was the optimal adhesion functional domain via segment expression and adhesion assays in vitro. Additionally, Adh induced partial protection against A. pleuropneumoniae 5b L20 and serotypes 1, 3, and 5a in mice. The deletion of Adh gene significantly decreased autoaggregation, biofilm formation and adherence to host cells in vitro. Furthermore, with delaying of clinical symptoms, reducing production of pro-inflammatory cytokines and lessening the lung injury after infection, Adh deletion strain (5bϕAdh) significantly reduced the pathogenicity to piglets. To elucidate the mechanism of lung injury, the differentially expressed genes in the lung tissues of piglets infected with the 5b L20 or 5bϕAdh strains were investigated using microarray analysis and validated by qRT-PCR. Compared with the 5b L20 infected piglets, 495 genes were differentially expressed in 5bϕAdh infected lung tissue (221 upregulated and 274 downregulated). Especially, the antigen processing and presentation gene IFI30 was increased following infection with the 5bϕAdh strain. Thus, Adh may enhance pathogenicity by depressing host immune recognition. We conclude that the head domain of the A. pleuropneumoniae trimeric autotransporter Apa1 regulates autoagglutination, biofilm formation, adhesion to host cells and pathogenicity.

  12. 6-APA中残留丙酮、甲基异丁基酮的测定%Determination on Residual Acetone and MIBK in 6-APA

    Institute of Scientific and Technical Information of China (English)

    赵娜; 宋雅丽; 郭云英

    2012-01-01

    采用直接进样色谱法测定,并用内标法(2-戊酮作内标物)定量,确定6-APA中残留丙酮、甲基异丁基酮的检测方法。经验证此法可准确测定6-APA中丙酮、甲基异丁基酮的残余量。%To develop a method for determination of residual acetone and MIBK in 6-APA through using injection chromatographic method and internal standard (2-pentanone) method. This method established on basis of verifica tion to determinate residual acetone and MIBK in 6-APA accurately.

  13. The psychometric properties of the personality inventory for DSM-5 in an APA DSM-5 field trial sample.

    Science.gov (United States)

    Quilty, Lena C; Ayearst, Lindsay; Chmielewski, Michael; Pollock, Bruce G; Bagby, R Michael

    2013-06-01

    Section 3 of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) includes a hybrid model of personality pathology, in which dimensional personality traits are used to derive one of seven categorical personality disorder diagnoses. The Personality Inventory for DSM-5 (PID-5) was developed by the DSM-5 Personality and Personality Disorders workgroup and their consultants to produce a freely available instrument to assess the personality traits within this new system. To date, the psychometric properties of the PID-5 have been evaluated primarily in undergraduate student and community adult samples. In the current investigation, we extend this line of research to a psychiatric patient sample who participated in the APA DSM-5 Field Trial (Centre for Addiction and Mental Health site). A total of 201 psychiatric patients (102 men, 99 women) completed the PID-5 and the Revised NEO Personality Inventory (NEO PI-R). The internal consistencies of the PID-5 domain and facet trait scales were acceptable. Results supported the unidimensional structure of all trait scales but one, and the convergence between the PID-5 and analogous NEO PI-R scales. Evidence for discriminant validity was mixed. Overall, the current investigation provides support for the psychometric properties of this diagnostic instrument in psychiatric samples.

  14. Association between vitamin D receptor ApaI and TaqI gene polymorphisms and gestational diabetes mellitus in an Iranian pregnant women population.

    Science.gov (United States)

    Rahmannezhad, Golzar; Mashayekhi, Farideh Jalali; Goodarzi, Mohammad Taghi; Rezvanfar, Mohammad Reza; Sadeghi, Abdorrahim

    2016-04-25

    It has been proposed that variants of the nuclear vitamin D receptor (VDR) gene are associated with a susceptibility to type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). Our study was aimed to evaluate a possible association between the VDR ApaI (rs7975232) and TaqI (rs731236) gene polymorphisms and susceptibility to GDM in an Iranian pregnant women population. This case-control study was performed on a population of pregnant Iranian women, including 157 GDM and 157 non-GDM subjects.VDR ApaI and TaqI polymorphisms were assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Our finding showed that the genotypes frequency of VDR ApaI polymorphism was significantly different between GDM and non-GDM groups (χ(2)=8.5, P=0.014). The CC genotype increased the risk of GDM as compared to the AA genotype (AA vs.CC, OR=2.996, 95% CI=1.278-7.022, P=0.012). The genotype and allele frequencies of VDR TaqI polymorphism were significantly different between GDM and non-GDM subjects (χ(2)=7.27, P=0.026, χ(2)=4.08, P=0.043 respectively). A significant protection was shown against GDM in VDR TaqI genotypes and allele (TT vs.TC, OR=0.523, 95% CI=0.23-0.84, P=0.007, TT vs. TC+CC, OR=0.546, 95% CI=0.35-0.86, P=0.009, T vs. C, OR=0.711, 95% CI=0.511-0.99, P=0.043). In conclusion, our findings show a significant association between VDR ApaI and TaqI gene polymorphisms and the GDM at the investigated loci.

  15. Association between VDR ApaI Polymorphism and Hip Bone Mineral Density Can Be Modified by Body Mass Index: A Study on Postmenopausal Chinese Women

    Institute of Scientific and Technical Information of China (English)

    Hong XU; Dong-Hai XIONG; Fu-Hua XU; Yuan-Yuan ZHANG; Shu-Feng LEI; Hong-Wen DENG

    2005-01-01

    Osteoporosis is a major public health problem for old people. Genetic factors are considered to be major contributors to the pathogenesis of postmenopausal osteoporosis. The vitamin D receptor (VDR)gene is a prominent candidate gene for the regulation of postmenopausal bone mass; however, despite extensive studies, controversy remains regarding its association with postmenopausal body mineral density (BMD)variation. In this study, a total of 260 healthy postmenopausal Chinese women were genotyped at the VDR ApaI locus using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Raw hip BMD was significantly associated with VDR ApaI polymorphism with and without adjusting for age(P=0.015 and 0.040, respectively). This genetic effect can explain 3.32% of hip BMD variation. However,the significant association vanished after correcting for both age and body mass index (BMI) (P=0.169). In addition, we observed a significant association between VDR ApaI polymorphism with unadjusted BMI(P=0.042) or BMI adjusted for age (P=0.049). The raw hip BMD was also found to be significantly correlated with BMI (r=0.517, P=0.0001), with BMI explaining 26.35% of the variation of hip BMD. All of these facts prompt us to conclude that the significant association between the VDR ApaI genotype and hip BMD may be modified by BMI in postmenopausal Chinese women. Our findings may partially explain the earlier inconsistent association results concerning the VDR gene and BMD, and highlight the importance of incorporating covariates such as BMI into osteoporosis association studies.

  16. Association of VDR ApaI and TaqI Gene Polymorphisms with the Risk of Scleroderma and Behçet's Disease.

    Science.gov (United States)

    Kamal, Asmaa; Gamal, Sherif M; Elgengehy, Fatema T; Alkemary, Alkhateeb K; Siam, Ibrahem

    2016-08-01

    Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been reported in autoimmune diseases. However, their role in Behçet's disease (BD) and scleroderma remains inconclusive. Our aim was to evaluate vitamin D receptor (ApaI, TaqI) gene polymorphisms in relation to Behçet's disease and scleroderma in Egyptians. The study was conducted on 54 patients with BD, 30 scleroderma patients, and 60 healthy control subjects. VDR (ApaI, TaqI) gene polymorphisms were investigated using polymerase chain reaction-restriction fragment length polymorphism technique. The "a" allele of ApaI (A/a) polymorphism was significantly associated with increased BD risk (OR = 2.09, 95% CI = 1.18-3.71, p = 0.011), while the TaqI "tt" genotype was significantly lower in BD patients as compared to control subjects (OR = 0.35, 95% CI = 0.13-0.9, p = 0.026). Carriage of "aT" VDR haplotype was significantly associated with higher BD risk (OR = 2.28, 95% = 1.14-4.56, p = 0.022). In conclusion, our findings suggest that VDR gene polymorphisms have a significant association with BD in Egyptian patients.

  17. O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection.

    Science.gov (United States)

    Nandakumar, Subhadra; Kannanganat, Sunil; Dobos, Karen M; Lucas, Megan; Spencer, John S; Fang, Sunan; McDonald, Melissa A; Pohl, Jan; Birkness, Kristin; Chamcha, Venkateswarlu; Ramirez, Melissa V; Plikaytis, Bonnie B; Posey, James E; Amara, Rama Rao; Sable, Suraj B

    2013-01-01

    Glycosylation is the most abundant post-translational polypeptide chain modification in nature. Although carbohydrate modification of protein antigens from many microbial pathogens constitutes important components of B cell epitopes, the role in T cell immunity is not completely understood. Here, using ELISPOT and polychromatic flow cytometry, we show that O-mannosylation of the adhesin, Apa, of Mycobacterium tuberculosis (Mtb) is crucial for its T cell antigenicity in humans and mice after infection. However, subunit vaccination with both mannosylated and non-mannosylated Apa induced a comparable magnitude and quality of T cell response and imparted similar levels of protection against Mtb challenge in mice. Both forms equally improved waning BCG vaccine-induced protection in elderly mice after subunit boosting. Thus, O-mannosylation of Apa is required for antigenicity but appears to be dispensable for its immunogenicity and protective efficacy in mice. These results have implications for the development of subunit vaccines using post-translationally modified proteins such as glycoproteins against infectious diseases like tuberculosis.

  18. 乳状液膜包酶制备6-APA的研究%Preparation of 6-APA by Enzymatic Bioconversion in an Emulsion Liquid Membrane Reactor

    Institute of Scientific and Technical Information of China (English)

    陆强; 胡鸣; 熊丹柳; 邓修

    2001-01-01

    Production of 6-aminopenicillanic acid (6-APA) by hydrolysis using penicillin acylase (PA) was studied as a model of an enzymatic emulsion liquid membrane (ELM) process. The loss of PA activity was examined for various membrane compositions (organic solvent, surfactant, carrier). The effects of some experimental variables on the stability of emulsion were investigated. It was found that the choice of organic solvent greatly affected the stability of the emulsion. Increasing the concentration of the carrier in the membrane phase increases the transfer rate of substrate and products but also has a destabilizing effect on the emulsion. The recovery of 6-APA obtained by a di-carrier system (N263-N1923) was much higher than those when either of the dj-carriers was used separately. The whole process was controlled both by the enzymatic reaction rate and by the transfer rate of the substrate and the products, however, the ratio of them could be changed by varying the composition of the system. For an optimum condition, it was obtained that the recovery ratio of 6-APA was over 80% and the conversion of benzyl penicillin (PG) was up to 90% in the external phase after 30 minutes. Meanwhile, the breakage percentage of the emulsion was less than 2%.``

  19. Hydrolysis of ibuprofenoyl-CoA and other 2-APA-CoA esters by human acyl-CoA thioesterases-1 and -2 and their possible role in the chiral inversion of profens.

    Science.gov (United States)

    Qu, Xiao; Allan, Amanda; Chui, Grace; Hutchings, Thomas J; Jiao, Ping; Johnson, Lawrence; Leung, Wai Y; Li, Portia K; Steel, Georgina R; Thompson, Andrew S; Threadgill, Michael D; Woodman, Timothy J; Lloyd, Matthew D

    2013-12-01

    Ibuprofen and related 2-arylpropanoic acid (2-APA) drugs are often given as a racemic mixture and the R-enantiomers undergo activation in vivo by metabolic chiral inversion. The chiral inversion pathway consists of conversion of the drug to the coenzyme A ester (by an acyl-CoA synthetase) followed by chiral inversion by α-methylacyl-CoA racemase (AMACR; P504S). The enzymes responsible for hydrolysis of the product S-2-APA-CoA ester to the active S-2-APA drug have not been identified. In this study, conversion of a variety of 2-APA-CoA esters by human acyl-CoA thioesterase-1 and -2 (ACOT-1 and -2) was investigated. Human recombinant ACOT-1 and -2 (ACOT-1 and -2) were both able to efficiently hydrolyse a variety of 2-APA-CoA substrates. Studies with the model substrates R- and S-2-methylmyristoyl-CoA showed that both enzymes were able to efficiently hydrolyse both of the epimeric substrates with (2R)- and (2S)- methyl groups. ACOT-1 is located in the cytosol and is able to hydrolyse 2-APA-CoA esters exported from the mitochondria and peroxisomes for inhibition of cyclo-oxygenase-1 and -2 in the endoplasmic reticulum. It is a prime candidate to be the enzyme responsible for the pharmacological action of chiral inverted drugs. ACOT-2 activity may be important in 2-APA toxicity effects and for the regulation of mitochondrial free coenzyme A levels. These results support the idea that 2-APA drugs undergo chiral inversion via a common pathway.

  20. Analgesic effect of intrathecal APA microcapsulized NIH3T3/rPENK on neuropathic pain induced by CCI in rats%蛛网膜下腔移植APA-MH3T3/rPENK对大鼠神经痛的镇痛效应

    Institute of Scientific and Technical Information of China (English)

    曹靖; 王振全; 任秀花; 张华; 张宏伟; 臧卫东

    2009-01-01

    目的:探讨海藻酸钠一聚赖氨酸.海藻酸钠(APA)微囊化转鼠前脑啡肽原基因NIH3T3细胞(APA-NIH3T3/rPENK)移植对大鼠神经痛的镇痛作用.方法:50只SD大鼠随机分为5组:CCI(坐骨神经慢性压迫)组、假手术组、APA空囊组、NIH3T3/rPENK组和APA-NIH3T3/rPENK组.测定CCI组和假手术组手术前后,APA空囊组、NIH333/rPENK组和APA-NIH3T3/rPENK组移植前后CCI术侧热痛阈,观察腹腔注射纳洛酮对细胞镇痛效应的影响,同时用放射免疫法检测脑脊液灌流液中亮氨酸脑啡肽(L-EK)含量.结果:CCI术后7~33 d术侧后爪热痛阈明显低于非术侧后爪(P<0.05).APA空囊组移植前后热痛阈未见明显变化;移植后NIH3T3/rPENK组和APA-NIH3T3/rPENK组热痛阈都明显高于APA空囊组(P<0.05).移植15 d后NIH333/rPENK组热痛阈显著低于APA-NIH3T3/rPENK组(P<0.05).移植21 d后APA空囊组脑脊液灌流液中L-EK含量显著低于NIH3T3/rPENK组和APA-NIH333/rPENK组(P<0.05);NIH3T3/rPENK组脑脊液灌流液中L-EK含量显著低于APA-NIH3T3/rPENK组(P<0.05).结论:NIH333/rPENK或APA-NIH3T3/rPENK植入大鼠的蛛网膜下腔可以明显减轻神经痛大鼠的热痛敏感行为.APA-NIH3T3/rPENK效果更明显,提示APA微囊具有良好的免疫隔离作用.

  1. Estratigrafía y petrología del sector noreste de sierra de Apas. Provincia del Chubut Stratigraphy and petrology of the Northeastern sector of Sierra de Apas. Chubut Province

    Directory of Open Access Journals (Sweden)

    M. Remesal

    2004-12-01

    Full Text Available La sierra de Apas, ubicada entre las provincias de Rio Negro y Chubut, forma parte del magmatismo de intraplaca emplazado durante el Paleogeno-Neógeno en el norte de la Patagonia extrandina. En el sector noreste se ha definido una estratigrafía integrada por: traquitas oscuras, flujos piroclásticos, traquitas claras, domos riolíticos y basaltos porfíricos y afíricos. Las traquitas oscuras, son relativamente más antiguas, tienen bajo porcentaje de fenocristales, y clasifican como traquitas- benmoreítas. Las traquitas claras son porfíricas, y clasifican como comenditas. Su ubicación estratigráfica es confirmada por una edad K/Ar de 19 ± 2 Ma. Los flujos piroclásticos son predominantemente vítreos, cubren a las traquitas oscuras y tienen composiciones traquiandesíticas. La petrografía y geoquímica establecen una estrecha relación con las traquitas claras. El único cuerpo dómico en el área es el cerro Colorado, cuya composición corresponde a una riolita peralcalina ó comendita; una edad K/Ar de 24 ± 1 Ma establece por primera vez su relación temporal. La unidad efusiva más joven corresponde a lavas basálticas, agrupadas en afíricas y porfíricas. Se propone designar a las primeras como basaltos olivínicos transicionales en tanto que los basaltos porfíricos se subdividen en basaltos olivínicos alcalinos y hawaiitas. Los datos estratigráficos y geoquímicos sugieren que la asociación volcánica estudiada es el resultado de al menos dos etapas evolutivas. Una de ellas incluye los basaltos, traquitas claras, flujos claros y comenditas que muestran un patrón de cristalización fraccionada. Las traquitas oscuras, más viejas, corresponderían a otro estadio evolutivo.The volcanic building of Sierra de Apas (located on the limit between the Rio Negro and Chubut provinces is part of the Paleogene-Neogene intraplate magmatism of the northern Extrandean Patagonia. This contribution is focused on the northeastern of the Sierra

  2. Prevalence of medicines used by mentally-ill individuals of APAE, in Londrina Prevalência de medicamentos utilizados por portadores de retardo mental da APAE de Londrina-Pr

    Directory of Open Access Journals (Sweden)

    Bruna Polacchine Da Silva

    2005-10-01

    Full Text Available Mental retardation (MR, after years of mites and beliefs, finally was considered to be a neurological affection that should be treated by a medical intervention. Psychotropic drugs, if correctly prescribed, are able to improve the capacity of MR individuals to productively interact socially and reintegrate themselves to the society. This work has as an objective to quantify, by a descriptive study, the frequency of use of medicines by students of the APAE (Associação de Pais e Amigos dos Excepcionais from Londrina-PR, characterize those drugs and relate them to mental pathologies of major prevalence in the institution. To accomplish the objectives, a pool was conducted on a population of 147 students registered during the period from January/1989 to May/ 2003. The results shown the following medicines: antiepiletic (52.4%, neuroleptics (3.4%, hematopoietics (2.7%, anticolinergics and pro-kinetics agents (0.7% each. Fenobarbital was the most evident among the antiepiletic (29.8%. The prevalence of those drugs was higher among individuals with cerebral palsy (62.1% and lower for the Down syndrome group (17,24%. As a conclusion, we consider necessary to conduct research projects focusing on the dynamic of the personnel affected by MR, as well as to provide social assistance to destitute families. O retardo mental (RM, após anos de crenças e misticismos, finalmente passou a ser considerado uma afecção neurológica que deve ser tratada com intervenção médica. As drogas psicotrópicas, se administradas corretamente, podem permitir que os acometidos de RM recuperem a capacidade de interação social produtiva e reintegrem-se à sociedade. Este trabalho teve como objetivo verificar, por meio de estudo descritivo, a freqüência da utilização de medicamentos utilizados pelos alunos da APAE (Associação de Pais e Amigos dos Excepcionais de Londrina-PR, caracterizar essas drogas e relacionálas com as patologias mentais de maior prevalência na

  3. Frå Apan fin (1999) til Hej då, lilla apa! (2008). Bildebok og animasjonsfilm – resepsjon og medieestetikk

    OpenAIRE

    Mjør, Ingeborg

    2013-01-01

    Artikkelen analyserer animasjonsfilmen Hej då, lilla apa! (2008), ein adaptasjon av Anna-Clara Tidholms små barnsbildebok Apan fin (1999). Filmen har reformulert nokre av bokas motiv og lagt til nye motiv, og artikkelen prøver for det første å grunngi desse endringane i resepsjonsperspektiv, det vil seie at endringane er gjort av omsyn til små barns (12 år) resepsjon. For det andre kan ein sjå filmen som eit produkt av medieestetiske omsyn, den er laga på filmmediets premissar, som på visse m...

  4. NASA AVOSS Fast-Time Models for Aircraft Wake Prediction: User's Guide (APA3.8 and TDP2.1)

    Science.gov (United States)

    Ahmad, Nash'at N.; VanValkenburg, Randal L.; Pruis, Matthew J.; Limon Duparcmeur, Fanny M.

    2016-01-01

    NASA's current distribution of fast-time wake vortex decay and transport models includes APA (Version 3.8) and TDP (Version 2.1). This User's Guide provides detailed information on the model inputs, file formats, and model outputs. A brief description of the Memphis 1995, Dallas/Fort Worth 1997, and the Denver 2003 wake vortex datasets is given along with the evaluation of models. A detailed bibliography is provided which includes publications on model development, wake field experiment descriptions, and applications of the fast-time wake vortex models.

  5. Study on industrialization of penicillin direct process of 6-APA%青霉素直通法生产6-APA工业化研究

    Institute of Scientific and Technical Information of China (English)

    李士杰; 魏光涛; 张琳叶; 贾荣荣

    2014-01-01

    为了降低6-氨基青霉烷酸(6-APA)的生产成本,采用了直通、脱酯、萃取工艺对6-APA的生产工艺进行了改进,使得总收率和质量得到提高,大幅度降低了6-APA的生产成本,提高了6-APA及后续产品的市场竞争力.

  6. A single dose of a DNA vaccine encoding apa coencapsulated with 6,6'-trehalose dimycolate in microspheres confers long-term protection against tuberculosis in Mycobacterium bovis BCG-primed mice.

    Science.gov (United States)

    Carlétti, Dyego; Morais da Fonseca, Denise; Gembre, Ana Flávia; Masson, Ana Paula; Weijenborg Campos, Lívia; Leite, Luciana C C; Rodrigues Pires, Andréa; Lannes-Vieira, Joseli; Lopes Silva, Célio; Bonato, Vânia Luiza Deperon; Horn, Cynthia

    2013-08-01

    Mycobacterium bovis BCG prime DNA (Mycobacterium tuberculosis genes)-booster vaccinations have been shown to induce greater protection against tuberculosis (TB) than BCG alone. This heterologous prime-boost strategy is perhaps the most realistic vaccination for the future of TB infection control, especially in countries where TB is endemic. Moreover, a prime-boost regimen using biodegradable microspheres seems to be a promising immunization to stimulate a long-lasting immune response. The alanine proline antigen (Apa) is a highly immunogenic glycoprotein secreted by M. tuberculosis. This study investigated the immune protection of Apa DNA vaccine against intratracheal M. tuberculosis challenge in mice on the basis of a heterologous prime-boost regimen. BALB/c mice were subcutaneously primed with BCG and intramuscularly boosted with a single dose of plasmid carrying apa and 6,6'-trehalose dimycolate (TDM) adjuvant, coencapsulated in microspheres (BCG-APA), and were evaluated 30 and 70 days after challenge. This prime-boost strategy (BCG-APA) resulted in a significant reduction in the bacterial load in the lungs, thus leading to better preservation of the lung parenchyma, 70 days postinfection compared to BCG vaccinated mice. The profound effect of this heterologous prime-boost regimen in the experimental model supports its development as a feasible strategy for prevention of TB.

  7. Association between FokI, ApaI and TaqI RFLP polymorphisms in VDR gene and Hashimoto's thyroiditis: preliminary data from female patients in Serbia.

    Science.gov (United States)

    Djurovic, J; Stojkovic, O; Ozdemir, O; Silan, F; Akurut, C; Todorovic, J; Savic, K; Stamenkovic, G

    2015-06-01

    Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder caused by an interaction between genes and environmental triggers. Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have shown association between vitamin D receptor (VDR) gene polymorphisms and various autoimmune diseases, including HT. The study included 44 female patients (mean age ± standard deviation 38 ± 5.4) with Hashimoto's thyroiditis and 32 healthy age-matched, sex-matched and geographically matched controls without personal history of autoimmune and endocrine diseases. Genomic DNA was isolated from peripheral blood-EDTA, and the target VDR gene was genotyped by PCR-RFLP technique after VDR-FokI (rs2228570), VDR-ApaI (rs7975232) and VDR-TaqI (rs731236) restriction enzymes digestion. We used spss 20.0 integrated software for data analysis and found a significant difference in the genotype distribution of VDR-FokI polymorphism between patients with HT and controls (P = 0.009). For ApaI and TaqI, we observed a higher frequency of variant allele in patients with HT, which was not significantly different compared to control women (P > 0.05). The current first and preliminary results identified the association between VDR-FokI gene polymorphism and Hashimoto's thyroiditis in Serbian population. Results need to be supported by further investigations that define haplotype patterns for VDR gene polymorphisms in a larger group of HT patients of both sexes.

  8. Apa antigen of Mycobacterium avium subsp. paratuberculosis as a target for species-specific immunodetection of the bacteria in infected tissues of cattle with paratuberculosis.

    Science.gov (United States)

    Souza, Giliane S; Rodrigues, Ana Bárbara F; Gioffré, Andrea; Romano, Maria I; Carvalho, Eulógio C Q; Ventura, Thatiana L B; Lasunskaia, Elena B

    2011-09-15

    Comparative genomics of Mycobacterium spp. have revealed conservative genes and respective proteins differently expressed in mycobacteria that could be used as targets for the species-specific immunodiagnostics. The alanine and proline-rich antigen Apa is a mycobacterial protein that present significant variability in primary sequence length and composition between members of M. avium and M. tuberculosis complexes. In this study, the recombinant Apa protein encoded by the MAP1569/ModD gene of M. avium subsp. paratuberculosis (Map) was used to generate a panel of monoclonal antibodies which were shown to recognize the most important veterinary pathogens of the M. avium complex, specifically Map and M. avium subsp. hominissuis, and which did not cross-react with M. bovis or M. tuberculosis. The produced antibodies were demonstrated to be a useful tool for the species-specific immunofluorescence or immunohistochemical detection of Map in experimentally infected cell cultures or intestinal tissues from cattle with bovine paratuberculosis and, additionally, they may be employed for the discrimination of pathogenic M. avium subspecies via Western blotting.

  9. The h index of the presidents of the American Psychological Association (APA through journal articles included in the Web of Science database

    Directory of Open Access Journals (Sweden)

    Gualberto Buela-Casal

    2011-01-01

    Full Text Available El presente estudio descriptivo analiza los índices h de los presidentes de la American Psychological Association (APA desde 1940 hasta la actualidad. El índice h se calcula teniendo en cuenta el número de artículos publicados en las revistas de la Web of Science (WOS y las citas recibidas por los mismos en dicha base de datos. No se estableció un periodo de búsqueda y, por tanto, se analizaron todos los resultados incluidos en la WOS. El número total de resultados analizados fue de 16.676, de los cuales 3.734 fueron de los presidentes de la APA. Los resultados se presentan en forma de ranking y ponen de manifiesto que Albert Bandura y Alan Kazdin son los presidentes con un índice h más elevado, y en entre estos y los demás existe una diferencia considerable. Los resultados hacen especular que el criterio de productividad en artículos científicos no fue el criterio más importante para presidir esta institución.

  10. Association of vitamin D receptor BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism with the nephrolithiasis susceptibility.

    Science.gov (United States)

    Zhou, Tian-Biao; Jiang, Zong-Pei; Li, Ai-Hua; Ju, Lang

    2015-04-01

    Association of vitamin D receptor (VDR) gene polymorphism with the risk of nephrolithiasis from the published reports is still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and the risk of nephrolithiasis using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Six reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with nephrolithiasis susceptibility. In this meta-analysis, VDR BsmI, Fok1, TaqI and ApaI gene polymorphism were not associated with nephrolithiasis susceptibility for overall populations and in Caucasians. However, the Fok1 f allele and ff genotype were associated with the risk of nephrolithiasis in Asians, but the FF genotype not. Furthermore, TaqI TT genotype was associated with the risk of nephrolithiasis in Asians, but the t allele and tt genotype not. However, ApaI gene polymorphism was not associated with nephrolithiasis susceptibility in Asians. In conclusion, VDR BsmI, Fok1, TaqI and ApaI gene polymorphism were not associated with nephrolithiasis risk in overall populations and in Caucasians. But, the Fok1 f allele and ff genotype, TaqI TT genotype, ApaI gene polymorphism were associated with the risk of nephrolithiasis in Asians. However, more studies should be conducted to confirm it.

  11. Os conselhos de meio ambiente e desenvolvimento da região da APA de Guaraqueçaba: relações, sobreposições e perspectivas futuras

    OpenAIRE

    Maya, Cecil; ICMBio; Mellinger, Larissa Lopes; Grupo Integrado de Estudos Ambientais; da Silva, Manuela Dreyer; Grupo Integrado de Estudos Ambientais; Limont, Marcelo; Mater Natura; Padilha, Renata Garrett; Mater Natura; Pereira, Leandro A.; Instituto Federal do Paraná

    2014-01-01

    O trabalho que segue busca analisar os resultados do levantamento de conselhos existentes na região da Área de Proteção Ambiental (APA) de Guaraqueçaba. Tal levantamento foi realizado no formato de um diagnóstico das competências e atribuições de conselhos de “meio ambiente” e de "desenvolvimento” atuantes nos municípios onde se insere a APA Federal de Guaraqueçaba, litoral norte do Paraná. Foram realizadas 16 entrevistas com gestores ou secretários executivos dos conselhos e acessados 22 doc...

  12. The association of vitamin D receptor gene Apa Ⅰ and Bsm Ⅰ polymorphism with systemic lupus erythematosus%维生素D受体Apa Ⅰ和Bsm Ⅰ位点基因多态性与系统性红斑狼疮相关性研究

    Institute of Scientific and Technical Information of China (English)

    罗雄燕; 唐中; 赵岩; 曾小峰; 袁国华; 武丽君; 陈龙; 杨明辉; 廖涛; 刘宁涛; 库尔班江; 谢传美; 史冉庚

    2012-01-01

    Objective To determine the distribution of vitamin D receptor (VDR) gene Apa Ⅰ and Bsm Ⅰ polymorphism in systemic lupus erythematosus (SLE) and the association with SLE in Chinese Han patients.Methods Genomic DNA from 244 Chinese SLE patients and 162 sex and ethnically matched controls were typed for VDR Apa Ⅰ and Bsm Ⅰ polymorphism combination by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Clinical characteristics were analyzed between different Apa ] and Bsm Ⅰ genotypes.Results There was no significant difference between the distribution frequencies of allelic gene A and a in SLE patients and the controls,but the distribution frequency of genotypes heterozygote Aa in SLE patients was higher than that in the controls ( 38.9% vs 22.2%,x2 =12.442,P =0.000).There was no significant difference between the distribution frequency of allelic gene and genotypes of Bsm Ⅰ in SLE patients and the controls ( P > 0.05 ).However,there was significant difference between the distribution frequencies of Apa Ⅰ and Bsm Ⅰ genotypes combination in SLE patients and the controls (x2 =18.226,P =0.006).The distribution frequency of genotypes Aa-bb in SLE patients was higher than that in the controls ( 32.4% vs 17.9%,x2 =10.449 P =0.001 ),while the distribution frequency of genotypes Aa-bb in SLE patients was lower than that in the controls (30.3% vs 42.0%,x2 =5.808,P =0.016). Furthermore,analyzing the effect of VDR Apa Ⅰ and Bsm Ⅰ polymorphism combination to the symptoms of SLE,significant difference was observed in SLE patients carrying Aa-bb genotypes involved in serositis ( P =0.003 ),hematological system disorder ( P =0.021 ),and anti-Sm antibodies ( P =0.01 ) compared with other genotypes.Conclusion There is significant association between Apa Ⅰ and Bsm Ⅰ gene polymorphism Aa-bb genotypes and the incidence of SLE in the Han population of China,and genotype Aa-bb is more involved in serositis,hematological system

  13. Introduction to the special issue: 50th anniversary of APA Division 28: The past, present, and future of psychopharmacology and substance abuse.

    Science.gov (United States)

    Stoops, William W; Sigmon, Stacey C; Evans, Suzette M

    2016-08-01

    This is an introduction to the special issue "50th Anniversary of APA Division 28: The Past, Present, and Future of Psychopharmacology and Substance Abuse." Taken together, the scholarly contributions included in this special issue serve as a testament to the important work conducted by our colleagues over the past five decades. Division 28 and its members have advanced and disseminated knowledge on the behavioral effects of drugs, informed efforts to prevent and treat substance abuse, and influenced education and policy issues more generally. As past and current leaders of the division, we are excited to celebrate 50 years of Division 28 and look forward to many more successful decades for our division and its members. (PsycINFO Database Record

  14. Comparative Analysis of Loading Mode Between RLWT and APA Rutting Test%RLWT与APA车辙试验加载模式比较分析

    Institute of Scientific and Technical Information of China (English)

    张俊标; 徐科; 张肖宁

    2006-01-01

    旋转车辙仪(RLWT-Rotary Loaded Wheel Tester or Rutmeter)于20世纪90 年代末开始在美国出现,因其轻便、易用,迅速受到关注.研究表明,RLWT与沥青路面分析仪(APA)、国际车辙仪的相关性都不理想.本文利用数字图像处理技术对RLWT与APA车辙试验的加载模式进行了分析,通过量测RLWT试件、APA试件与原样试件中粗集料颗粒长轴与X轴夹角的差异,得出结论:RLWT与APA车辙试验的加载模式存在较大差异.

  15. 中日韩APA比较及对我国的启示%A Comparison of APAs among Japan, Korea and China and Their Implications

    Institute of Scientific and Technical Information of China (English)

    李本贵; 刘馨颖

    2006-01-01

    通过对中日韩三国APA实施情况及程序的比较,得出以下启示:中国的APA不仅要针对境内的外商投资企业,还要为中国企业走出去提供相应的税收服务;应多签订双边或多边APA;APA的重点应放在制造业和零售业的纳税人;APA的管理权限应相对集中;APA适用的时间应与国际惯例基本一致.

  16. Expectation and Satisfaction of Parents or Tutors of Users of APAE Assisted at Special Patient Dental Clinic of Dentistry School of Montes Claros State University, Unimontes/MG

    Directory of Open Access Journals (Sweden)

    Luiza Augusta Rosa ROSSI-BARBOSA

    2007-03-01

    Full Text Available Objective: To evaluate expectation and satisfaction of parents/tutors of users of the Association of Parents and Friends of People with Disability (APAE assisted at the clinic of special patients of the Dentistry School of Unimontes, during the year of 2004 and the first school semester of 2005. Method: In the first consultation, 46 people were evaluated concerning expectation of clinical assistance and, in the end of the treatment, 89.0% of these people answered a satisfaction questionnaire. The statistical analysis applied were Pearson Qui-square test and Fisher exact test (p<0.05. Results: 84.8% have already been assisted at Dental Clinics at Unimontes. Considering expectation of assistance, 71.7% expected dental fillings, 65.2% dental prophylaxes, 45.7% treatment with speech-language pathologist, 41.3% treatment with physiotherapist, 37.0% tooth extraction and 23.9% treatment for tooth pain. Relation to satisfaction, 78.1% conceptualized dental assistance as great and 21.9% as good. Professor recommendations to students were classified as great by 75.6% of interviewed. Considering professional recommendations, 97.5% considered important those given by dentist, 56.1% by speech-language pathologist and 56.1% by physiotherapist. Conclusion: The most frequent expectations reported by the parents/tutors of the users of the clinics have involved the surgical and restorative dental treatment. Researchers were satisfied with the dental assistance. A significant number of users of the APAE were not assisted by physiotherapist and by speech-language pathologist, having, as a result, a low percentage in the evaluation of these services.

  17. The Mycobacterium tuberculosis cell-surface glycoprotein apa as a potential adhesin to colonize target cells via the innate immune system pulmonary C-type lectin surfactant protein A.

    Science.gov (United States)

    Ragas, Aude; Roussel, Lucie; Puzo, Germain; Rivière, Michel

    2007-02-23

    Tuberculosis is still a major health problem, and understanding the mechanism by which Mycobacterium tuberculosis (Mtb) invades and colonizes its host target cells remains an important issue for the control of infection. The innate immune system C-type lectins (C-TLs), including the human pulmonary surfactant protein A (PSP-A), have been recently identified as determinant players in the early recognition of the invading pathogen and in mounting the host defense response. Although the antigenic lipoglycan mannosylated lipoarabinomannan is currently considered to be the major C-TL target on the mycobacterial surface, the recognition by some C-TLs of the only mycobacterial species composing the "Mtb complex" indicates that mannosylated lipoarabinomannan cannot account alone for this specificity. Thus, we searched for the mycobacterial molecules targeted by human PSP-A, focusing our attention on the Mtb surface glycoproteins. We developed an original functional proteomic approach based on a lectin blot assay using crude human bronchoalveolar lavage fluid as a source of physiological PSP-A. Combined with selective cell-surface protein extraction and mass spectrometry peptide mapping, this strategy allowed us to identify the Apa (alanine- and proline-rich antigenic) glycoprotein as new potential target for PSP-A. This result was supported by direct binding of PSP-A to purified Apa. Moreover, EDTA addition or deglycosylation of purified Apa samples completely abolished the interaction, demonstrating that the interaction is calcium- and mannose-dependent, as expected. Finally, we provide convincing evidence that Apa, formerly considered as mainly secreted, is associated with the cell wall for a sufficiently long time to aid in the attachment of PSP-A. Because, to date, Apa seems to be restricted to the Mtb complex strains, we propose that it may account for the selective recognition of those strains by PSP-A and other immune system C-TLs containing homologous functional

  18. Association of Vitamin D Receptor Apa I Gene Polymorphism and Immunological Abnormality in Patients with Vitiligo%白癜风患者维生素D受体Apa I基因多态性及免疫异常的研究

    Institute of Scientific and Technical Information of China (English)

    孙越; 韩菁; 吴瑞勤; 谢匡成; 朱光斗; 施伟民

    2011-01-01

    Objective To investigate the association between vitamin D receptor (VDR) Apa Ⅰ gene polymorphism and immunological abnormality on vitiligo patients. Methods VDR genotypes of 46 vitiligo patients and 50 healthy controls were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP). We also measured the levels of immunoglobulin IgG, IgM, IgA and complements C3, C4 and T lymphocyte subpopulations CD3+, CD4+ and CD8+ of peripheral blood. Results ①There was significant difference in genotype distribution of VDR-Apa Ⅰ polymorphisms between vitiligo patients, whose frequency of aa is higher(P<0.05), and normal controls. ② Vitiligo patients with Aa, aa had higher level of IgA than control cases, and the C3 measured in aa genotype showed the same trend (P<0.01). ③ Compared with normal controls,the percentage of CD3+ was significantly lower in vitiligo patients with aa genotype (P<0.05). Conclusion It suggests that VDR is a susceptible gene for involving in vitiligo, and aa is the susceptible genotype·for vitiligo patients. Immunological abnormality may exist in vitiligo patients with aa genotype. Our study also indicates that the pathogenesis of vitiligo might have some connection with VDR gene and immunological abnormality.%目的 探讨白癜风维生素D(VDR)受体Apa I基因多态性及其与免疫异常的关系.方法 采用聚合酶链反应和限制性片段长度多态性方法,对46例白癜风患者和50例健康人的VDR Apa I基因多态性进行分析,以及各基因型与外周血免疫球蛋白IgA、IgM、IgG,补体C3、C4以及T细胞亚群CD3+、CD4+、CD8+之间的关系.结果 ①VDR-Apa I位点的aa基因型在白癜风患者中出现的频率高于正常对照组(P<.05).②Aa、aa基因型组白癜风患者血清免疫球蛋白IgA水平显著低于正常对照组(P<0.05与P<0.01),aa基因型患者补体C3水平显著低于正常对照组(P<0.01).③aa基因型组白癜风患者的CD3+T淋巴细

  19. Finite Element Simulation of RLWT and APA Test Principle%RLWT与APA试验原理的有限元模拟

    Institute of Scientific and Technical Information of China (English)

    吴国平; 葛折圣

    2012-01-01

    近年来,沥青路面的高温抗车辙性能与设计标准的符合性备受关注.多轮车辙仪RLWT和沥青路面分析仪APA是用来检测路面芯样抗车辙性能的重要仪器.通过有限元分析,比较了2种仪器的试验原理.结果表明,RLWT试验方法对试件内部损伤的反应更加敏感;试件承受整体的剪切和弯拉作用;试件表面2 cm以下,RLWT试件的剪应力和剪应变明显大于APA试件,RLWT试验方法更侧重于对试件的剪切性能的评价.因此,对于高温下混合料芯样抗剪切性能的评价,优先选用RLWT试验方法.研究成果对沥青路面施工质量和对于设计的符合性检验具有重要的指导意义.%In recent years, compliance of high-temperature ruaing resistance performance of asphalt pavement with design standards is oconcerned. Rotary Loaded Wheel Tester or Rutmeler( RLWT) and Automated Asphalt Pavement Analyzer( APA) is important instruments, which is used to detect anti-rutting performance of pavement core samples. Through a finite element simulation,iheir principle were analyzed. The results show that, RLWT test methods on the response of the specimen is more sensitive to internal damage; the whole specimen under shear and bending effects; 2 cm specimen surface the following, RLWT specimen shear stress and shear strain was significantly greater than the APA specimens, RLWT test method is more focused on the shear properties of the specimen evaluation. Therefore, to evaluate shear performance of asphalt mixture core sample under high temperature, the preferred test method is RLWT. Research has important guiding significance to examine the compliance of high-temperature performance of asphalt pavement with design standards.

  20. Reservations about the conclusions of the interdivisional (APA Divisions 12 & 29) task force on evidence-based therapy relationships: what do we know, what don't we know?

    Science.gov (United States)

    Kazantzis, Nikolaos; Cronin, Timothy J; Norton, Peter J; Lai, Jerry; Hofmann, Stefan G

    2015-05-01

    We offer a critical and constructive appraisal of the conclusions provided by the Interdivisional (American Psychological Association [APA] Divisions 12 & 29) Task Force on Evidence-Based Therapy Relationships. We highlight problems in overlapping terminology and definitions, as well as problems in the conduct of its meta-analyses (i.e., duplication of studies between reviews, inappropriate study inclusion, and use of measures of specific constructs for the calculation of effects for multiple relationship elements). On this basis, we express reservation about the conclusions offered by the APA Task Force. This special issue explores whether there are other therapeutic relationship elements that warrant consideration and further study. We were particularly interested in those elements that showed promise based on empirical or theoretical grounds, and in each article, we asked for an account of how the case formulation would guide the methods of adaptation for each individual client, and how the element would contribute to clinically relevant changes.

  1. 抗脑垂体抗体与脑外伤后垂体功能障碍的相关性研究%The relationship between the antipituitary antibodies (APAs) and hypopituitarism after traumatic brain injury

    Institute of Scientific and Technical Information of China (English)

    张名均; 曹冠柏; 冯铃; 胡巧铃; 王德树; 吴俊; 陈文浩

    2012-01-01

    目的 探讨抗脑垂体抗体(APAs)与脑外伤后垂体功能减退及脑损伤程度的关系.方法 将73例脑外伤后9 ~12个月且垂体激素均有不同程度下降的患者按入院时格拉斯哥昏迷指数(GCS)评分分成A(3 ~8)、B(9 ~12)、C(13 ~ 15)3组,分别测定其血液中垂体激素[生长激素(GH)、总睾酮(TT)、游离三碘甲状腺原氨酸(FT3)、促卵泡刺激素(FSH)/黄体生成素(LH)]和APAs水平.激素采用化学发光法测定,APAs采用酶联免疫吸附法(ELISA)检测.结果 A组的APAs水平显著高于B、C组(P<0.001),而B、C组间差异无统计学意义(P>0.05);A组所测激素的水平均显著低于B、C组(P<0.001),而B、C组间差异无统计学意义(p>0.05).统计显示,患者APAs水平与GH水平呈负相关(r=-0.64071,P<0.001),与GCS评分亦呈负相关(r=-0.50132,P<0.001).结论 APAs的产生与脑外伤有关,损伤程度与APAs水平成正相关,与GH等垂体激素水平成负相关.结果 表明通过测定APAs水平可以推测脑外伤后期脑垂体功能下降的概率和程度.%Objective To investigate the relationship between antipituitary antibodies (APAs) and hypopituiarism following traumatic brain injury (TBI),as well as the severity of brain injury.Methods The study included 73 patients who suffered TBI 9 to 12 months ago and were diagnosed with hypopituitarism during the follow-up.Based on their Glasgow Coma Scale (GCS) on admission they were categorized into three groups:A (3-8),B (9-12) and C (13-15).Levels of plasma pituitary hormones (GH,TT,FT3 and FSH/LH) and APAs were measured in all patients with chemiluminescence assays and ELISA,respectively.Results Patients in group A had higher levels of APAs and lower levels of hormones compared with those in group B(P<0.001) or group C(P<0.001),while no significant difference was found between group B and group C for levels of either APAs (P>0.05) or hormones (P>0.05).Levels of APAs were negatively correlated

  2. RECENZJA KSIĄŻKI "WHY ARE YOU SO SCARED? A CHILD'S BOOK ABOUT PARENTS WITH PTSD", B. ANDREWS. WASHINGTON: APA, 2012

    Directory of Open Access Journals (Sweden)

    Wiśniewska, Lidia Anna

    2014-12-01

    Full Text Available The aim of this paper is to present a child’s book „Why Are You So Scared? A Child’s Book About Parents with PTSD”, B. Andrews (illustrations by: K. Kirkland. Washington: APA, 2012. The book is devoted to children whose parents suffer from PTDS. The language used is intelligible for children. A huge advantage of this book are beautiful illustrations and possibilities for children to express their emotions through drawings. The author describes a complex disorder – PTSD – in a clear and comprehensible way. It seems that the book – although dedicated to children – offers a valuable assistance for therapists and psychologists working with families of people with PTSD, as for parents themselves as well. In the same series were published also two different books – for children of parents with depression („Why Are You So Sad? A Child’s Book About Parental Depression” and for military children („I Miss You ! A Military Kid’s Book About Deployment”.

  3. Referenciación bibliográfica en ciencias de la educación: criterios de la APA y un ejemplo de gestión a través del programa END-NOTE

    OpenAIRE

    Cubo Delgado, Sixto; González Gómez, José Juan; González Chaves, Silvia

    2004-01-01

    Whith this paper we aim at offering a global picture of the criteria of bibliographical reference that is more frequently used in the educational field. We specially deal with the criteria proposed by the American Psychological Association (APA) for being the ones more used in this context.After the exposition fo the above mentioned criteria and the reference to several works as example, we propose some procedures to index the documents obtained by electronic resources, emphasizing the intern...

  4. Synthesizing and Structure Analysis of A Novel Inner-added A gent APA-1220 Used In Anionic Dyestuff%一种新型的内添加型染色助剂APA-1220 的合成及结构表征

    Institute of Scientific and Technical Information of China (English)

    兰云军; 谷雪贤; 罗卫平

    2005-01-01

    针对目前我国染料工业存在的问题及国内外染料的发展趋势及需要,以长链脂肪族烷基伯胺为原料,经多步反应制得了一种新型的内添加型染色助剂APA-1220.在合成实验中,通过化学分析方法初步确定了各步反应的合成工艺条件.此外,还通过红外、元素分析等现代分析手段对各步反应的产物进行了结构表征及分析.

  5. Qualidade da pastagem nativa obtida por diferentes métodos de amostragem e em diferentes solos na Apa do Ibirapuitã, Brasil Quality of natural pasture evaluated with different methods and soils at the Apa of Ibirapuitã, Brazil

    Directory of Open Access Journals (Sweden)

    Vicente Celestino Pires Silveira

    2005-06-01

    Full Text Available O estado do Rio Grande do Sul apresenta ecossistemas heterogêneos, devido ao grande número de tipos de solo e à variação em altitude e clima, que se reflete na diversidade da composição florística das diferentes comunidades vegetais. A Área de Proteção Ambiental do Ibirapuitã (APA do Ibirapuitã, é a única unidade de conservação federal, representante do bioma campos sulinos no Brasil. O objetivo deste trabalho foi obter informação sobre a qualidade do campo natural oriundo de três tipos de solos predominantes na APA do Ibirapuitã: Basalto superficial, Basalto profundo e Arenito obtidos por três formas de amostragem: Corte de emparelhamento, Simulação de pastejo através de coleta manual e Corte total acima da fração mantilho. Os dados foram coletados mensalmente, no período de outubro/2001 a setembro/2003. A pastagem nativa no solo de Basalto superficial apresenta forragem com qualidade nutricional superior quando comparado ao Basalto profundo e ao Arenito, comprovada pelas diferentes análises de qualidade realizadas. O método de coleta de amostras de forragem de pastagem nativa somente não influencia os resultados da análise de Fibra em Detergente Neutro. Os resultados indicam a simulação de pastejo como um método adequado de amostragem para avaliação da qualidade da pastagem nativa, devido à sua efetividade e facilidade de coleta.Heterogeneous ecosystems are found in the state of Rio Grande do Sul as a consequence of the great number of soil types and variation in altitude and climate. These conditions reflect on the great variety of flora present in the grassland communities. The Area of Environmental Protection of the Ibirapuitã (APA of Ibirapuitã is the only conservation unit under federal jurisdiction representative of the Campos bioma in Brazil. The objective of this work was to obtain information about the quality of the natural pasture on three types of soils in APA of Ibirapuitã: Superficial

  6. 某抗生素生产企业职业接触7-ACA和6-APA 工人健康状况研究%Investigation on health status of workers exposed to 7-ACA and 6-APA in an antibiotic enterprise

    Institute of Scientific and Technical Information of China (English)

    高珊珊; 李侠; 宋占帅; 陈晓文; 郑传斌; 徐明

    2016-01-01

    Objective To investigate the health status of workers exposed to 7-aminocephalosporanic acid (7-ACA) and 6-aminopenicillanic acid (6-APA) in an antibiotics enterprise.Methods Using simple random sampling method, 207 workers exposed to 7-ACA and 6-APA from an antibiotic production enterprise were selected as the exposed group , and 162 workers with no dust exposure history from the same antibiotic production enterprise were selected as control group .Health examinations were performed .The health status of the workers were analyzed .Results The detection of symptoms ( chest distress, shortness of breath, cough, wheezing, itchy skin) and allergic diseases (bronchial asthma, allergic rhinitis, allergic dermatitis) in exposed group were higher than those in control group (P<0.05).The lung function indexes such as forced vital capacity (FVC), forced expiratory volume in first second (FEV1) and FEV1/FVC in the exposed group were lower than those in control group ( P<0.05 ) .There was no significant difference in the lung function indexes , respiratory and skin allergy symptoms , and allergic diseases between 7-ACA subgroup and 6-APA subgroup ( P<0.017 ) . The incidence of bronchial asthma , allergic rhinitis had statistical differences in the length of dust exposure in service workers ( P <0.05 ) .Conclusion Workers exposed to 7-ACA and 6-APA have a high occurrence rate of respiratory symptoms.These workers also suffered from occupational diseases such as bronchial asthma , allergic rhinitis and others .%目的:调查某抗生素生产企业职业接触7-氨基头孢烷酸(7-ACA)和6-氨基青霉烷酸(6-APA)工人健康状况。方法采用单纯随机抽样法,以某抗生素生产企业职业接触7-ACA和6-APA的207名工人为接触组,以该企业无粉尘接触史的162名工人为对照组。对2组工人职业健康检查结果进行分析。结果接触组工人胸闷、咳嗽、气短、喘息、皮肤瘙痒等症状的发生率,以及支气

  7. Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma (APA).

    Science.gov (United States)

    Nakamura, Yasuhiro; Hattangady, Namita G; Ye, Ping; Satoh, Fumitoshi; Morimoto, Ryo; Ito-Saito, Takako; Sugawara, Akira; Ohba, Koji; Takahashi, Kazuhiro; Rainey, William E; Sasano, Hironobu

    2014-03-25

    Aberrant expression of gonadotropin-releasing hormone receptor (GnRHR) has been reported in human adrenal tissues including aldosterone-producing adenoma (APA). However, the details of its expression and functional role in adrenals are still not clear. In this study, quantitative RT-PCR analysis revealed the mean level of GnRHR mRNA was significantly higher in APAs than in human normal adrenal (NA) (P=0.004). GnRHR protein expression was detected in human NA and neoplastic adrenal tissues. In H295R cells transfected with GnRHR, treatment with GnRH resulted in a concentration-dependent increase in CYP11B2 reporter activity. Chronic activation of GnRHR with GnRH (100nM), in a cell line with doxycycline-inducible GnRHR (H295R-TR/GnRHR), increased CYP11B2 expression and aldosterone production. These agonistic effects were inhibited by blockers for the calcium signaling pathway, KN93 and calmidazolium. These results suggest GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases of APA.

  8. The analgesic effect of APA microcapsulized BCCs subarachnoid transplantation on animal models of neuropathic pain%APA微囊化BCCs蛛网膜下腔移植对大鼠慢性神经性疼痛的镇痛效应

    Institute of Scientific and Technical Information of China (English)

    徐龙河; 薛毅珑; 罗芸; 郭水龙; 张宏

    2004-01-01

    目的:观察 APA 微囊化牛肾上腺嗜铬细胞(BCCs) 移植对大鼠慢性神经性疼痛的作用.方法: SD 大鼠 4 组,即对照组(C 组),正常大鼠;单纯 CCI 组,右侧坐骨神经松结扎;CCI 注入 APA 组和 APA-BCCs 组,CCI 模型后 7 d,蛛网膜下腔分别移植 500~600 个 APA 空囊和 5×106 个 APA 微囊化 BCCs.测定各组移植后 7 d 至 42 d 的触诱发痛阈值(g)和 CO2 激光刺激痛阈值(ms).并取脊髓行 TH、 ENK、DβH 免疫组化检测.结果:APA-BCCs 组结扎侧触诱发痛阈值和 CO2 痛阈值在移植后 7~42 d 均高于 CCI 组和 APA 组(P0.05).移植后的 BCCs TH 染色阳性,脊髓软膜可见到 DβH 和 ENK 免疫组化染色阳性.结论: APA 微囊化 BCCs 蛛网膜下腔移植可缓解 CCI 模型大鼠的痛觉过敏和触诱发痛,ENK 和 NE 参与其镇痛作用机制.

  9. Association of vitamin D receptor FokI and ApaI polymorphisms with human cytomegalovirus disease in the first three months following kidney transplantation

    Institute of Scientific and Technical Information of China (English)

    ZHAO Yu-gang; SHI Bing-yi; XIAO Li; QIAN Ye-yong; FENG Kai; HE Xiu-yun; XU Xiao-guang

    2012-01-01

    Background Untreated human cytomegalovirus (CMV) disease (CMVD) is an identified risk factor for reduced rates of patient (and graft) survival,death or retransplantation in kidney transplant recipients due to increased immunological tolerance after transplant.Vitamin D receptor (VDR) gene polymorphisms have an obvious relationship with autoimmune diseases but the relationship between VDR gene polymorphisms and CMVD are not well understood.This study investigated the relationship between VDR Fokl and Apal gene polymorphisms and CMVD,and their value for predicting risk of CMVD.Methods Ninety-eight kidney transplantation recipients were randomly chosen for which peripheral blood samples and case histories for the first three months after kidney transplantation were obtained.Using polymerase chain reaction-restriction fragment length polymorphisms,30 recipients were found to be homozygous for the Fokl gene (FF),47 heterozygous (Ff),and 21 were homozygous (ff).Likewise,similar analyses determined that 12 recipients were homozygous for the Apa/ gene (AA),36 heterozygous (Aa),and 50 homozygous (aa).Factors affecting the prognosis of the kidney transplantation were compared for all genotypes by statistical analysis before operation.Infection by CMV for all recipients was detected by immunofluorescence assay to diagnose CMVD.Results No statistical significance was observed for the factors affecting the prognosis of the kidney transplantation between both genotypes; however,statistical differences in CMVD among the Fokl genotypes were identified.It was determined that the risk of CMVD was significantly increased for recipients of the ff genotype than for other genotypes.There was no statistical significance observed for CMVD among Apal genotypes.Conclusions The recessive f allelic gene of VDR can be regarded as a risk factor of CMVD while FF recipients have lower incidence of CMVD after kidney transplantation.Apal genotypes showed no relationship with predisposition to CMVD

  10. 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism Apa1 influence bone mineral density in primary hyperparathyroidism.

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    Monika H E Christensen

    Full Text Available OBJECTIVE: Parathyroid hormone (PTH and vitamin D are the most important hormones regulating calcium metabolism. In primary hyperparathyroidism (PHPT excessive amounts of PTH are produced. Bone turnover is enhanced, leading to reduced bone mineral density and elevated levels of serum calcium. The aim of this study was to investigate relations between serum levels of 25-hydroxyvitamin D (25(OHD, 1,25-dihydroxyvitamin D (1,25(OH(2D and bone mineral density, as well as known genetic polymorphisms in the vitamin D receptor and enzymes metabolising vitamin D in patients with PHPT. DESIGN/SUBJECTS: We conducted a cross-sectional study of 52 patients with PHPT. RESULTS: Mean level of 25(OHD was 58.2 nmol/L and median 1,25(OH(2D level was 157 pmol/L. Among our patients with PHPT 36.5% had 25(OHD levels below 50 nmol/L. Serum 1,25(OH(2D was inversely correlated to bone mineral density in distal radius (p = 0.002, but not to bone mineral density at lumbar spine or femoral neck. The vitamin D receptor polymorphism Apa1 (rs7975232 was associated with bone mineral density in the lumbar spine. CONCLUSIONS: The results suggest that PHPT patients with high blood concentrations of 1,25(OH(2D may have the most deleterious skeletal effects. Randomized, prospective studies are necessary to elucidate whether vitamin D supplementation additionally increases serum 1,25(OH(2D and possibly enhances the adverse effects on the skeleton in patients with PHPT.

  11. Parâmetros nutricionais da pastagem natural em diferentes tipos de solos na APA do Ibirapuitã, Rio Grande do Sul - Brasil Nutritional parameters of natural pasture in different soils at APA of Ibirapuitã, Rio Grande do Sul - Brazil

    Directory of Open Access Journals (Sweden)

    Vicente Celestino Pires Silveira

    2006-12-01

    Full Text Available O desempenho de ruminantes domésticos é influenciado por fatores intrínsecos ao animal, ao alimento e pela interação entre animal e alimento. O trabalho foi realizado na Estância do 28, pertencente à Fundação Maronna, Alegrete - RS, dentro da APA do Ibirapuitã. Para representar o fator solo, foram escolhidos os três tipos predominantes da APA do Ibirapuitã: Basalto Superficial, Basalto Profundo e Arenito. As amostras da pastagem natural foram retiradas por simulação de pastejo, através de coleta manual. Os parâmetros nutricionais avaliados foram: proteína bruta, fibra em detergente neutro e taxa de degradação da matéria seca. A forragem da pastagem natural oriunda do solo Basalto Superficial apresentou diferença significativa (PIntrinsic animal and food factors and the interaction between them influence the performance of domestic ruminants. This study was done at Estância do 28, property of the Maronna Foundation, Alegrete - RS, inside the Ibirapuitã Area of Environmental Protection. In order to represent soil as a factor, the three main soil types were chosen: Superficial Basalt, Deep Basalt and Sandy. Hand plucking methods were used to obtain samples of natural pasture. Nutritional parameters considered were crude protein, neutral detergent fiber and dry matter degradation rate. The forage from natural pasture of the Superficial Basalt presented significant difference (P<0.05 in crude protein rates over the other two types of soil, which did not differ amongst themselves. The highest rate of neutral detergent fibre (84.54% was obtained in pasture originated from Sandy soil, in relation to Superficial and Deep Basalt, with values of 74.53% and 77.98%, respectively. There was also a significant difference in the degradation rate of dry matter (P<0.05. Sandy soil pasture presented an intermediate degradation value (3.61% h-1, not differing from other soils. The forage from natural pastures present similar degradation rates

  12. BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR and Association with Lumbar Spine Pathologies: An Italian Case-Control Study.

    Directory of Open Access Journals (Sweden)

    Alessandra Colombini

    Full Text Available Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR BsmI (rs1544410, ApaI (rs7975232, and TaqI (rs731236 are commonly studied in several pathologies. We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an Italian cohort of 266 patients with lumbar spine disorders assessed by Magnetic Resonance Imaging and 252 asymptomatic controls. The exposure to putative risk factors was evaluated by a questionnaire. Polymorphisms were detected by PCR-RFLP and TaqMan® SNP Genotyping Assay. The results were statistically adjusted for the identified conventional risk factors. The three SNPs were in linkage disequilibrium. For all cases BbAaTT was a 3-fold risk factor OR = 3.38, whereas bbAATT (OR = 0.22, and bbaaTT (OR = 0.47 genotypes were found to be protective. Specifically, for patients affected by disc herniation only (n = 88 and all lumbar pathologies excluding stenosis and/or spondylolistesis (n = 215 B allele, Bb, Aa, and BbAaTT genotypes were risky, whereas b allele, bb, aa, and bbaaTT genotypes were protective. In patients affected by osteochondrosis with or without disc hernation (n = 50, T allele, Aa, and bbAaTT genotypes were risky, whereas t allele, AA, tt genotypes were protective. In patients affected by stenosis and/or spondylolistesis (n = 51 no significant associations were found. This is the first study showing an association of the three genetic VDR variants BsmI, ApaI, and TaqI and lumbar spine pathologies. Our study contributes to delineate genetic risk factors for specific subgroups of patients with lumbar spine pathologies highlighting the importance of haplotype analysis, and of detailed clinical evaluation of the patients for identification of genetic biomarkers.

  13. BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR) and Association with Lumbar Spine Pathologies: An Italian Case-Control Study

    Science.gov (United States)

    Colombini, Alessandra; Brayda-Bruno, Marco; Lombardi, Giovanni; Croiset, Samantha Jennifer; Ceriani, Cristina; Buligan, Cinzia; Barbina, Mattia; Banfi, Giuseppe; Cauci, Sabina

    2016-01-01

    Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) are commonly studied in several pathologies. We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an Italian cohort of 266 patients with lumbar spine disorders assessed by Magnetic Resonance Imaging and 252 asymptomatic controls. The exposure to putative risk factors was evaluated by a questionnaire. Polymorphisms were detected by PCR-RFLP and TaqMan® SNP Genotyping Assay. The results were statistically adjusted for the identified conventional risk factors. The three SNPs were in linkage disequilibrium. For all cases BbAaTT was a 3-fold risk factor OR = 3.38), whereas bbAATT (OR = 0.22), and bbaaTT (OR = 0.47) genotypes were found to be protective. Specifically, for patients affected by disc herniation only (n = 88) and all lumbar pathologies excluding stenosis and/or spondylolistesis (n = 215) B allele, Bb, Aa, and BbAaTT genotypes were risky, whereas b allele, bb, aa, and bbaaTT genotypes were protective. In patients affected by osteochondrosis with or without disc hernation (n = 50), T allele, Aa, and bbAaTT genotypes were risky, whereas t allele, AA, tt genotypes were protective. In patients affected by stenosis and/or spondylolistesis (n = 51) no significant associations were found. This is the first study showing an association of the three genetic VDR variants BsmI, ApaI, and TaqI and lumbar spine pathologies. Our study contributes to delineate genetic risk factors for specific subgroups of patients with lumbar spine pathologies highlighting the importance of haplotype analysis, and of detailed clinical evaluation of the patients for identification of genetic biomarkers. PMID:27149110

  14. EPS-APA顺应国际节能减碳发展理念%EPS-APA Conforms to the Developing Concept of Energy Conservation and Carbon Dioxide Reduction

    Institute of Scientific and Technical Information of China (English)

    张国锋

    2010-01-01

    @@ 2009年,宝马、采埃孚转向系统部门与康迪泰克公司共同开发了一套具有轴平衡(APA)电子机械转向系统(电动助力转向系统,简称EPS).康迪泰克为电动助力转向系统的同步带驱动装置开发了斜齿带(CONTI SLT POWER).

  15. Evaluación de las potencialidades para el serodiagnóstico de la tuberculosis en Cuba del antígeno APA45/47 kDa de Mycobacterium tuberculosis

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    Astrid Ramos Mori

    2004-01-01

    Full Text Available La tuberculosis (Tb continúa siendo la enfermedad infecciosa de mayor prevalencia en el mundo, no solo en países subdesarrollados, sino también, en los desarrollados donde la Tb ha reemergido en los últimos años y constituye uno de los principales problemas de salud. Cuba se encuentra entre estos últimos. Teniendo en cuenta que alrededor de un tercio de la población mundial está infectada con el agente causal, el bacilo Mycobacterium tuberculosis, el diagnóstico temprano y eficaz es vital para el control de la expansión de la enfermedad y su mortalidad. Empleando la metodología del ELISA se evaluó el complejo antigénico 45/47 kDa o APA (antígeno rico en prolina y alanina de M. tuberculosis para el serodiagnóstico de la Tb en la población cubana. Para ello, se determinaron los anticuerpos reactivos contra dicha proteína recombinante obtenida de E. coli, presentes en los sueros de individuos sanos vacunados con BCG, enfermos de Tb e individuos sanos no vacunados mayores de 60 años. Los resultados evidenciaron que la respuesta contra APA de los enfermos fue significativamente mayor que la de los sanos vacunados, pero no se observaron diferencias significativas en este sentido entre los sanos no vacunados y los primeros. El método presentó una especificidad del 86 % y una sensibilidad del 39 %, por lo que la proteína APA recombinante evaluada tiene poco valor para el diagnóstico de la Tb en Cuba considerando que lo más importante dada la situación actual de reemergencia es la detección de los enfermos. El tiempo de tratamiento de los enfermos pudiera afectar la respuesta de anticuerpos contra APA, ya que se observó que el 89,4 % de estos individuos que fueron identificados como tal mediante este ensayo tenían menos de 60 d (d con medicación.

  16. Construction of a visual determination method on the thickness and surface of APA Microcapsules by optica microscopy with frozen section and the ice emission scanning electron microscopy%采用冰冻切片和冷场发射电镜构建APA微囊的膜厚度及膜表面测定的方法研究

    Institute of Scientific and Technical Information of China (English)

    傅红兴; 李慧; 朱雁林; 赵应征; 吴岚岚; 江玲

    2013-01-01

    目的:建立一种APA微囊的膜厚度以及表面结构的检测方法,并测定微囊在湿状态的膜厚度和干燥后的膜表面结构.方法:采用亚甲蓝染色、冰冻切片结合光学显微镜观察微囊的膜厚度,并将囊膜在37℃孵育30 d后再次观察厚度的变化;对微囊进行冷冻干燥和冷场发射观察囊膜表面和断面结构.结果:APA-Ca和APA-Ba微囊的囊膜厚度并不均匀,孵育1个月后囊膜厚度变化差异无统计学意义(P>0.05);冷场发射扫描电镜下显示,两种微囊表面均光滑、致密;冻干后APA-Ca囊膜厚度达450 ~690 nm,而APA-Ba的囊膜厚度约为350 nm.结论:建立了一种简单、可靠的微囊膜厚度和表面检测方法,为进一步研究APA微囊的质量奠定了基础.%Objective: To explore a visual methold of the membrane thickness of APA microcapsules and their surface structures, and determinate the film thickness and surface characteristics. Methods: We use methyl-ene blue to dye the film of microcapsules, then within frozen section and optical microscope the the thickness of microcapsule were observed; and the thickness of microcapsules hatched in 37 ℃ for a month were also assayed. The surface of membrane were studied by ice emission scanning electron microscopy after lyophilization. Results: The member thickness of each APA microencapsules is not uniform. After incubated for 30 d in 37 ℃, there is no obviously difference in the thichness than befor (P>0.05). Surfaces of two microencapsules are smooth and compact under the scanning electron microscopy. The thickness of APA-Ca microcapsules are 450-690 nm, which of APA-Ba are about 350 nm. Conclusion: The essay provided a simple method on how to determine the membrane thickness and surface, which would be an important reference to expound the APA microcapsules.

  17. Comunicação ambiental: estratégias de mobilização socioparticipativa para educação, informação e integração da rede socioambiental APA SUL RMBH

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Andrade

    2010-01-01

    Full Text Available This article aims at introducing and analyzing communication models used in the socio-environmental network APA SUL RMBH, an environmentally sensitive area in which polemic issues and economicinterests are involved. These models provide inter-sectorial, participative, egalitarian and dynamic dialogues and information in order to put emphasis on the mobilization that characterizes the communicative process. The definition of common purposes, social actors and their roles, the active participation of all members of the community as well as the planning for more efficiency in the process reveal strategies of mobilization which structure themselves “with” and not “for” society. In this context, the usufruct and the consolidation of effective communication tools like, for example, permanent forums for debates, informational booklet, social research, training of local staff within a virtual and high-tech structuralmodel – Portal (or Site of the socio-environmental network APA SUL RMBH – have become a foundation for the convocation of common purposes and the establishment of social networks. Thus, the weaving and the crossing of these relationships outline an interconnected set of complementary factorsthat govern social mobilization in this socio-biodiversity area.

  18. Vitamin D receptor gene FokI but not TaqI, ApaI, BsmI polymorphism is associated with Hashimoto’s thyroiditis: a meta-analysis

    Science.gov (United States)

    Wang, Xiaofei; Cheng, Wenli; Ma, Yu; Zhu, Jingqiang

    2017-01-01

    Four VD receptor (VDR) gene polymorphisms (TaqI, ApaI, FokI and BsmI) have been reported to influence Hashimoto’s thyroiditis (HT) risk. However, individual studies have produced inconsistent results. We conducted a comprehensive meta-analysis of eleven case-control studies to better understand roles of the four polymorphisms in HT development. The results showed only FokI polymorphism was significantly associated with the risk of HT (F vs f: OR = 1.44, 95% CI = 1.09–1.91, P = 0.010; FF vs Ff + ff: OR = 1.72, 95% CI = 1.09–2.70, P = 0.019). Subgroup analyses demonstrated the significant effect was only present in Asian population (F vs f: OR = 1.45, 95% CI = 1.07–1.95, P = 0.016; FF vs ff: OR = 1.64, 95% CI = 1.03–2.59, P = 0.036; FF + Ff vs ff: OR = 1.34, 95% CI = 1.00–1.80, P = 0.047; FF vs Ff + ff: OR = 1.64, 95% CI = 1.03–2.64, P = 0.039), but not in Caucasian. For TaqI, ApaI and BsmI polymorphisms, no significant association was found in any model comparison. Based on the current literature, it appears that only VDR FokI polymorphism is associated with HT risk in Asian population, but not in Caucasians; and the TaqI, ApaI and BsmI polymorphisms have not positive association neither in the overall population, nor when stratified by ethnicity. Further well-designed studies with larger sample sizes and different ethnic population are needed to clarify the present findings. PMID:28134349

  19. Valoração contingente da Área de Proteção Ambiental (APA São José - MG: um estudo de caso

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    Jader Fernandes Cirino

    2008-09-01

    Full Text Available A Área de Proteção Ambiental (APA São José - MG apresenta um rico patrimônio natural e histórico. Apesar de tal fato e de ser uma área de proteção desde 1981, a APA São José vem sofrendo com degradações ambientais. Dentro desse contexto, emergiu a questão de se valorar a APA São José com o objetivo de fornecer subsídios para a elaboração e consecução de políticas públicas e de projetos públicos e privados de conservação ou exploração sustentável do referido ativo. Como método de valoração, utilizou-se a valoração contingente, por meio da abordagem de Hanemann (1984 e o método de bootstrapping, para obter uma disposição a pagar (DAP mensal por família dos cinco municípios que compreendem a APA São José, de R$ 22,88, com um desvio padrão relativamente baixo de R$ 3,25. Quanto à confiabilidade da medida estimada, destaca-se a preocupação do presente trabalho em adotar procedimentos visando evitar ou minimizar os viéses que geralmente ocorrem em pesquisas de valoração ambiental.The São José Environmental Protection Area (EPA in the State of Minas Gerais has a rich natural and historical patrimony. However, in spite of its value and of being a protection area since 1981, it has now suffering several degradations. In that sense, the major objective of this work is to value São José EPA with the purpose of supplying subsidies for the elaboration and attainment of public and private projects of preservation or sustainable exploration of the referred asset, as well as for public policy directed to its administration. As valuation method, it was used the contingent valuation through the approach of Hanemann (1984 and the bootstrapping method to obtain a monthly willingness-to-pay (WTP per family of the municipal districts that compose São José EPA of R$22,88, with a relatively low standard-error, R$3,25. As for the reliability of the estimate measure, stands out the concern of the present work in

  20. Ambulatório de genética médica na Apae: experiência no ensino médico de graduação

    OpenAIRE

    2008-01-01

    Este trabalho relata uma experiência de ensino cujo objetivo foi oferecer formação significativa e integradora na área de genética médica aos graduandos de medicina do Centro Universitário Barão de Mauá. Para isto, em 2005, foi estruturado um ambulatório de genética médica na Associação de Pais e Amigos dos Excepcionais (Apae) do município de Jardinópolis (SP), como parte do estágio de internato em Saúde Coletiva e Medicina da Família e Comunidade, realizado nos serviços de saúde desse municí...

  1. Produção familiar de leite e de saber: a extensão rural no controle da mastite e qualidade do leite na APA Coqueiral, MG

    OpenAIRE

    Barros,Rodrigo Alves

    2014-01-01

    Produção Familiar de Leite e de Saber na Área de Proteção Ambiental, APA - Coqueiral é um programa interdisciplinar, interdepartamental. O foco é a produção de leite em sistema familiar e sua relação com a preservação ambiental e melhores condições de vida da população envolvida neste processo. A produção leiteira não é a principal atividade econômica da comunidade e apresenta inconformidades quanto às normas de qualidade vigentes para o produto. Os objetivos foram avaliar os índices de masti...

  2. Association between vitamin D receptor gene BsmI, FokI, ApaI and TaqI polymorphisms and the risk of systemic lupus erythematosus: a meta-analysis.

    Science.gov (United States)

    Mao, Song; Huang, Songming

    2014-03-01

    Association studies of vitamin D receptor (VDR) gene polymorphisms and the risk of systemic lupus erythematosus (SLE) have yielded conflicting results in different backgrounds. We aimed to evaluate the association between VDR gene polymorphisms and SLE risk. A predefined electronic databases search was performed to identify eligible studies that were related to the association of VDR gene BsmI, FokI, ApaI or TaqI polymorphism with SLE risk. Either a fixed-effects model, or in the presence of heterogeneity, a random-effects model was used to calculate the pooled odds ratios (ORs) and its corresponding 95% confidence interval (CI). A total of 11 studies with 1,621 cases and 1,883 controls were included in this meta-analysis. BsmI B allele was associated with the onset of SLE for overall populations (OR 1.726, 95% CI 1.214-2.455) and Asians (OR 1.952, 95% CI 1.135-3.355). FokI FF genotype was correlated with the susceptibility of SLE for Asians (OR 1.469, 95% CI 1.005-2.148). FokI T/C and TaqI polymorphisms were not associated with SLE risk for Caucasians. There was no significant association between ApaI polymorphism and SLE risk for overall populations, Asians and Caucasians. No evidence of publication bias was observed. In conclusion, BsmI B allele may be a risk factor for SLE onset among overall populations and Asians, and FokI FF genotype is a risk factor for SLE susceptibility in Asians. However, more studies should be performed in the future.

  3. Scale-up from shake flasks to bioreactor, based on power input and Streptomyces lividans morphology, for the production of recombinant APA (45/47 kDa protein) from Mycobacterium tuberculosis.

    Science.gov (United States)

    Gamboa-Suasnavart, Ramsés A; Marín-Palacio, Luz D; Martínez-Sotelo, José A; Espitia, Clara; Servín-González, Luis; Valdez-Cruz, Norma A; Trujillo-Roldán, Mauricio A

    2013-08-01

    Culture conditions in shake flasks affect filamentous Streptomyces lividans morphology, as well the productivity and O-mannosylation of recombinant Ala-Pro-rich O-glycoprotein (known as the 45/47 kDa or APA antigen) from Mycobacterium tuberculosis. In order to scale up from previous reported shake flasks to bioreactor, data from the literature on the effect of agitation on morphology of Streptomyces strains were used to obtain gassed volumetric power input values that can be used to obtain a morphology of S. lividans in bioreactor similar to the morphology previously reported in coiled/baffled shake flasks by our group. Morphology of S. lividans was successfully scaled-up, obtaining similar mycelial sizes in both scales with diameters of 0.21 ± 0.09 mm in baffled and coiled shake flasks, and 0.15 ± 0.01 mm in the bioreactor. Moreover, the specific growth rate was successfully scaled up (0.09 ± 0.02 and 0.12 ± 0.01 h(-1), for bioreactors and flasks, respectively), and the recombinant protein productivity measured by densitometry, as well. More interestingly, the quality of the recombinant glycoprotein measured as the amount of mannoses attached to the C-terminal of APA was also scaled- up; with up to five mannose residues in cultures carried out in shake flasks; and six in the bioreactor. However, final biomass concentration was not similar, indicating that although the process can be scaled-up using the power input, others factors like oxygen transfer rate, tip speed or energy dissipation/circulation function can be an influence on bacterial metabolism.

  4. Análise da riqueza da fauna de Braconidae (Hymenoptera, Ichneumonoidea em remanescentes naturais da Área de Proteção Ambiental (APA de Descalvado, SP

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    Cirelli Kátia Resende Netto

    2003-01-01

    Full Text Available Analysis of the Braconidae (Hymenoptera: Ichneumonoidea fauna richness in natural remnants of the Área de Proteção Ambiental (APA of Descalvado, SP. A survey of the Braconidae fauna on fragmentary natural environments at northeast São Paulo State was conducted using Malaise traps installed in five sites of Área de Proteção Ambiental of Descalvado. A total of 2,262 specimens, representing 22 subfamilies and 94 genera, was sampled throughout a period of sixteen months (from May, 1999 to August, 2000. Biological data were obtained from current literature and behavior patterns of host utilization for the studied fauna, mainly Braconidae which have been successful in control of agricultural insect pests. Statistical analyses indicated that the asymptote of the genera richness has been approached using this sampling method. This is the most complete survey yet available from natural fragmentary areas of the Descalvado Braconidae fauna. Patterns of distribution and richness of the Braconidae genera were established. Cluster Analysis was adopted taking as attribute the number of Braconidae genera.

  5. Study on relationship between ApaI site polymorphism of vitamin D receptor gene and hereditary susceptibility to childhood acute leukemia%维生素D受体基因与儿童急性白血病遗传易感性的关系研究

    Institute of Scientific and Technical Information of China (English)

    郑敏; 罗建明; 何云燕

    2011-01-01

    目的 探讨维生素D受体(VDR)基因ApaI位点多态性与儿童急性白血病遗传易感性的关系.方法 采用聚合酶链限制性片段长度多态性技术和基因测序技术,对127例急性白血病患儿和268例健康儿童的VDR基因ApaI位点多态性进行分析.结果 VDR基因ApaI酶切位点基因型和等位基因的频率在急性白血病患儿和正常儿童之间差异无统计学意义.结论 VDR基因ApaI酶切位点的多态性可能与儿童急性白血病的遗传易感性无关.%Objective To investigate the relationship between Apal site gene polymorphism of vitamin D receptor ( VDR) and hereditary susceptibility to acute childhood leukemia.Methods Polymerase chain reaction restrictive fragment length polymorphism analysis technique and DNA sequencing technology were used to detect polymorphisms of VDR gene Apal locus in 127 children with acute leukemia and 268 healthy children (as controls).Results No significant differences in genotype distribution frequencies and the allele gene distribution frequencies of VDR gene Apal locus were found between the two groups.Conclusions The gene polymorphisms of VDR gene Apal enzyme digestion locus may not be related to genetic susceptibility to acute childhood leukemia.

  6. L'activité physique adaptée pour les personnes atteintes de diabète de type 2 : approche sociologique des "carrières de pratiquant d'APA" dans leurs relations avec la "trajectoire de maladie"

    OpenAIRE

    Barth, Nathalie

    2012-01-01

    Alongside prescription medication, it is recommended that type 2 diabetes patients (T2D) carry out regular adaptedphysical activity (APA), in the same way that they should adopt a new dietary balance (HAS 2006). This incitement to bringabout concrete changes in lifestyle comes up against opposition which is compounded where the patient does not have ahistory of regular physical exercise. Some health organizations have devised innovative arrangements such as health networks,or inter-disciplina...

  7. POLA PENDIDIKAN KITA, APA YANG SALAH

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    Alpiyanto Alpiyanto

    2012-06-01

    Full Text Available AbstractIdeals to the intellectual life of the nation by order of value as thefoundation of ethics and moral domains of intelligence and skill has beendisoriented. It can be seen from the culture of corruption that stillplagued the country, beating punishment of journalists that was hitby students of SMAN 6 Jakarta, clashes among students in Lampung, clashes among residents in different regions and the church bombing inSolo. Therefore, this study wanted to find out what went wrong to educationthat has been implemented so far. This study is a case study of thepatterns which are applied during this study. The study results showed that theeducation that has been implemented so far seems to be concerned with the logicrather than feelings (language of heart so it is suggested that it is important to educate the heart rather than logic.Keywords: educate, by heart, logic

  8. INFLUÊNCIA DOS FATORES GEOLÓGICOS, GEOMORFOLÓGICOS E ANTRÓPICOS DA PRODUÇÃO DE FLUXO DE BASE EM PEQUENAS BACIAS HIDROGRÁFICAS NA APA CACHOEIRA DAS ANDORINHAS, OURO PRETO (MG

    Directory of Open Access Journals (Sweden)

    Josefa Clara Monteiro

    2014-08-01

    Full Text Available Neste trabalho objetivou-se estabelecer a influência da geologia, geomorfologia e uso e ocupação do solo no potencial hídrico de pequenas bacias hidrográficas situadas na Área de Proteção Ambiental Estadual da Cachoeira das Andorinhas (APA/CA. Foram selecionados três pares de bacias, cada par com condições geológicas e geomorfológicas semelhantes, mas com graus distintos de interferência antrópica. Utilizando-se dados de chuva e vazão, obtidos durante um ano hidrológico, estabeleceram-se os regimes pluviométricos e fluviométricos e determinaram-se alguns parâmetros hidrológicos, como o fluxo de base pela técnica smoothed mínima e o coeficiente de recessão (α pela técnica matching strip. A análise conjugada destes parâmetros, de índices morfométricos e de dados físico-químicos das águas indicam que as bacias em áreas de relevo mais suave tendem a apresentar menores coeficientes de recessão e maiores volumes de fluxo de base. Portanto, nestas áreas o potencial hídrico é maior, já que a vazão das drenagens se mantém por mais tempo na estação seca. O relevo mais suave, com solo mais espesso e maior tempo de trânsito das águas subterrâneas, também justificam as águas mais redutoras e com maiores condutividades elétricas. Os dados também sugerem que as bacias da área com maiores proporções de florestas tendem a apresentar menores fluxos de base por conta das maiores taxas de evapotranspiração. Os métodos aplicados se mostraram adequados para caracterizar o regime hídrico de pequenas bacias hidrográficas e podem ser importantes para a gestão de recursos hídricos.

  9. Analysis of the Practice Guideline for the Treatment of Patients with Major Depressive Disorder in APA, 3rd Edition%美国精神病协会抑郁障碍患者治疗实践指南(第三版)解析

    Institute of Scientific and Technical Information of China (English)

    王学义; 李凝

    2012-01-01

    The American Psychiatric Association (APA) made the new practice guideline for the treatment of patients with major depressive disorder, and the practice guideline for the treatment of patients with major depressive disorder, 3rd edition has been published in October 2010. The new guideline mainly consists of three parts( A,B and C) .adding the newest evidence-based medical evidences and treatment ideas. Part A involves the treatment advice;part B involves the background and assessment among the data presented; part C involves the problems to be resolved in the future researches. Every part has been given some analyses.%美国精神病协会(APA)于2010年10月出版了《抑郁障碍患者治疗实践指南,第3版》.新版指南增加了最新的循证医学证据和治疗理念,由三部分(A、B、C)组成.A部分是治疗建议,B部分是背景资料和现有证据评价,C部分是未来研究的问题.每部分均作了相应的的解读.

  10. Trajetórias do Jaguary - unidades de conservação, percepção ambiental e turismo: um estudo na APA do Sistema Cantareira, São Paulo Trajectories of the Jaguary conservation areas, environmental perception and tourism a study in the Cantareira system environmental protected area, São Paulo

    Directory of Open Access Journals (Sweden)

    João Luiz Hoeffel

    2008-06-01

    Full Text Available A Área de Proteção Ambiental Cantareira (APA Cantareira tem passado por diversas transformações, associadas à expansão urbana e turística. Observa-se, nesta pesquisa, que os grupos sociais atuantes nessa região apresentam diferentes perspectivas sobre meio ambiente e desenvolvimento, o que tem gerado conflitos de uso pelos recursos naturais, e que não existem planos regionais que apontem soluções efetivas para os problemas socioambientais em curso.The Cantareira Environmentally Protected Area (EPA Cantareira has been undergoing several transformations due to the growth of urban areas and tourism. The present piece of research points out that the active social groups in this region have different perspectives to the environment and development. This leads to conflicts in the use of natural resources and there are no regional plans suggesting effective solutions for the identified social and environmental problems.

  11. What Is Psychiatry?

    Medline Plus

    Full Text Available ... APA Blogs Annual Meeting Advocacy & APAPAC APA Sites APA Publishing APA Learning Center APA Foundation APA Annual Meeting ... Medical Students International Become a Fellow APA Sites APA Publishing APA Foundation APA Learning Center APA Annual Meeting ...

  12. APA微囊化BCCs移植逆转神经性疼痛大鼠背根神经节Navl.8 mRNA表达下调%Reversion of down-regulated mRNA expression for Nav1.8 in dorsal root gangliaof rats with neuropathic pain by APA microcapsulized BCCs subarachnoid transplantation

    Institute of Scientific and Technical Information of China (English)

    徐龙河; 薛毅珑; 罗芸; 郭水龙; 张宏

    2004-01-01

    目的观察APA微囊化牛肾上腺嗜铬细胞(BCCs)移植对坐骨神经慢性挤压伤(CCI)大鼠背根神经节(DRG)Nav1.8 mRNA表达的影响.方法 SD大鼠分为4组,每组5只,即对照组(C组),正常大鼠;CCI组,右侧坐骨神经结扎;APA组,CCI模型后7 d,蛛网膜下腔移植500~600个APA空囊;APA-BCCs组,CCI模型后7 d蛛网膜下腔移植5×106个APA微囊化BCCs.测定各组移植前和移植后7d的触诱发痛阈值(g)和CO2激光刺激痛阈值(ms).移植后7 d行为学测定后取DRG冰冻切片,按照原位杂交法检测各组DRG中Nav1.8 mRNA表达的变化.结果 CCI组和APA组大鼠L4和L5 DRG Nav1.8杂交信号较C组明显降低(P<0.01),两组间差异无显著性(P>0.05).APA-BCCs组扎侧触诱发痛阈值和CO2痛阈值高于CCI组和APA组结扎侧(P<0.01),同时DRG中Nav1.8杂交信号较CCI组和APA组明显升高(P<0.01),于C组差异无显著性(P>0.05).结论 APA微囊化BCCs蛛网膜下腔移植可使CCI大鼠DRG中表达量下降的Nav1.8 mRNA恢复正常表达,APA微囊化BCCs蛛网膜下腔移植的镇痛作用和促进DRG中Nav1.8 mRNA表达恢复有关.

  13. Spinal NO pathway takes part in the analgesic effect of APA microcapsulized BCCs subarachnoid transplantation%脊髓NO通路参与APA微囊化牛肾上腺嗜铬细胞蛛网膜下隙移植镇痛机理

    Institute of Scientific and Technical Information of China (English)

    徐龙河; 薛毅珑; 罗芸; 郭水龙; 张宏

    2004-01-01

    目的通过观察APA微囊化牛肾上腺嗜铬细胞(BCCs)移植对坐骨神经慢性挤压伤(CCI)大鼠脊髓神经元型一氧化氮合酶(Nnos)的影响,探讨脊髓NO通路是否参与APA微囊化BCCs蛛网膜下隙移植镇痛机理.方法 SD大鼠分为四组,每组5只,即对照组(C组),正常大鼠;CCI组,右侧坐骨神经结扎;APA组,CCI模型后1周,蛛网膜下隙移植500~600个APA空囊;APA-BCCs组,CCI模型后1周蛛网膜下隙移植5×106个APA微囊化BCCs.测定各组移植后1周的感觉异常和痛觉过敏阈值,感觉异常以Von Frey细丝触诱发痛阈值(g)表示,痛觉过敏阈值用CO2激光刺激痛阈值(ms)表示.动物处死后取脊髓冰冻切片,按照标准免疫组化法检测各组脊髓中Nnos的表达变化.结果 CCI组、APA组脊髓中Nnos活性较C组明显升高(P<0.01),但CCI组和APA组间无显著差异(P>0.05);APA-BCCs组结扎侧触诱发痛阈值和CO2痛阈值高于CCI组和APA组结扎侧(P<0.01),同时脊髓中Nnos活性较CCI组和APA组明显降低(P<0.01),与C组基本相同(P>0.05).结论 CCI大鼠脊髓Nnos表达增加,APA微囊化BCCs蛛网膜下隙移植缓解CCI大鼠的触诱发痛和痛觉过敏,同时降低CCI大鼠脊髓Nnos表达,提示脊髓NO通路参与APA微囊化BCCs蛛网膜下隙移植的镇痛作用.

  14. Effect of P deficiency and Al stress on root tip of pigeon pea and the activities of acid phosphatase(APA) excreted from root tip%低磷与铝毒胁迫对木豆根尖及其分泌的酸性磷酸酶活性的影响

    Institute of Scientific and Technical Information of China (English)

    秦丽凤; 左方华; 段居琪; 玉永雄; 黎晓峰; 顾明华

    2006-01-01

    通过对木豆在低磷和铝毒胁迫下根尖内及根尖分泌的酸性磷酸酶(APA)活性的动态变化规律研究,旨在了解木豆对缺磷和铝胁迫的适应性机制,为木豆在酸性土壤上的栽培提供依据.结果表明:低磷(1μmol·L-1 P)使根尖内及根尖分泌的APA活性显著增加,并且低磷诱导根尖内APA活性增加早于根尖分泌的APA活性增加,在低磷胁迫的第7d,木豆根尖内APA活性达到最高,而根尖分泌的APA活性于第9d才达到最高.低磷引起的根尖及其分泌的APA活性增加在供磷24h后即显著降低,说明APA活性的增强是植物对低磷胁迫的适应性反应.另一方面,20μmol·L-1Al虽然使低磷胁迫下植株根尖内的APA活性显著降低,但根尖分泌的APA活性却有所增加,说明在低磷胁迫下铝引起根系分泌的APA活性增加可能是木豆适应酸性土壤逆境的重要机制.

  15. How to Use Current Medical Literature and APA Format Style.

    Science.gov (United States)

    Peek, Robin

    Directives and guidance in obtaining current medical literature are provided in this publication with special emphasis given to locating material in the Portland, Oregon area. The uses and types of periodical indexes are identified and periodical index citation examples are indicated. Explanations are offered on: (1) how to conduct an effective…

  16. The future of EUNA APA: action and invitation

    NARCIS (Netherlands)

    Meeteren, N. van; Erwin, T.

    2012-01-01

    Abstract for the International Society for Aging and Physical activity's 8th World Congress on Aging and Physical Activity: A celebration of Diversity and Inclusion in Active Ageing, August 13-17 2012.

  17. Memahami Nyanyian Jemaat Sebagai Sentral Musik Gereja Apa dan Bagaimana?

    Directory of Open Access Journals (Sweden)

    Rohani Siahaan

    2012-10-01

    Full Text Available Banyak orang yang menganggap bahwa nyanyian jemaat dalamibadah tidak terlalu penting dibandingkan dengan nyanyian paduansuara atau musik lainnya yang ada di gereja. Dengan anggapan bahwajemaat sudah mengenal, sudah mengetahui, bahkan sudah menguasailagunya, maka tidak perlu ada persiapan atau pun latihan. Tentu saja inianggapan yang sangat keliru. Setiap umat hendaknya memahami bahwanyanyian jemaat yang digunakan dalam rangkaian liturgi ibadahharuslah dipersiapkan, dilatih, dan dipersembahkan dengan sebaikbaiknya.Sikap peduli nyanyian jemaat perlu dipertahankan, pemeliharaanbuku nyanyian harus terus menerus dilakukan. Memang harus diakui,kesalahan seringkali terjadi seperti: penggunaan lagu dari minggu keminggu itu-itu saja – tidak sesuai dengan tematik ibadah, kurang variatif,selera siapa (? – penempatan nyanyian tidak sesuai dengan rumpunibadah – lagu tidak sesuai dengan kalender gereja, tidak sesuai dengandoktrin gereja – tetapi semua itu merupakan hal yang masih bisadihindari bahkan diperbaiki demi mencapai kesempurnaan.

  18. Violence against Teachers: Case Studies from the APA Task Force

    Science.gov (United States)

    Reddy, Linda A.; Espelage, Dorothy; McMahon, Susan D.; Anderman, Eric M.; Lane, Kathleen Lynne; Brown, Veda Evanell; Reynolds, Cecil R.; Jones, Abraham; Kanrich, Jaclyn

    2013-01-01

    Violence directed toward teachers has been understudied despite significant media and empirical investigation on school violence, such as student-to-student victimization and bullying. To date, there are relatively few published studies scattered across many countries. To address this void, the American Psychological Association, in collaboration…

  19. Developement and goals of the EUNA APA network

    NARCIS (Netherlands)

    Hopman-Rock, M.

    2012-01-01

    Abstract for the International Society for Aging and Physical activity's 8th World Congress on Aging and Physical Activity: A celebration of Diversity and Inclusion in Active Ageing, August 13-17 2012.

  20. Preparing Special Education Research Articles in APA Style.

    Science.gov (United States)

    Algozzine, Bob; Spooner, Fred; Karvonen, Meagan

    2002-01-01

    This article addresses key considerations in preparing special education research articles for submission to professional journals in which the preferred style guide is the "Publication Manual of the American Psychological Association." The guidelines are drawn from special education literature, from editors, and from authors experienced in…

  1. Putting the APA "Publication Manual" in Context. Commentary.

    Science.gov (United States)

    Russo, Nancy Felipe

    1999-01-01

    Explores feminist criticism of the "Publications Manual" of the American Psychological Association and the ways in which feminist researchers have negotiated changes in the language of this style guide. (SLD)

  2. The APA classification of mental disorders: future perspectives.

    Science.gov (United States)

    Regier, Darrel A; Narrow, William E; First, Michael B; Marshall, Tina

    2002-01-01

    After 8-10 years of experience with the fourth edition of the Diagnostic and Statistical Manual (DSM-IV) and the tenth edition of the International Classification of Diseases (ICD-10), it is an ideal time to begin looking at the clinical and research consequences of these diagnostic systems. The American Psychiatric Association, in conjunction with the National Institutes of Health, has initiated a research development process intended to accelerate an evaluation of existing criteria while developing and testing hypotheses that would improve the validity of our diagnostic concepts. Over the past year, a multidisciplinary, international panel has developed a series of six white papers which define research opportunities in the following broad areas: Nomenclature, Disability and Impairment, Personality Disorders, Relational Disorders, Developmental Psychopathology, Neuroscience, and Cross-Cultural aspects of Psychopathology. Recommendations for future national and international research in each of these areas will be discussed.

  3. Mencegah Korupsi di Pengadaan Barang dan Jasa : Apa yang sudah dan yang masih harus dilakukan?

    NARCIS (Netherlands)

    Wibowo, R.A.

    2015-01-01

    This paper aims to explore and to give appreciation for the efforts which have been done by the Indonesian government to prevent corruption in public procurement, such as: (i) designing procurement organisational structure which enables more checks and balances on the system; and (ii) designing the

  4. 76 FR 37876 - Hours of Service (HOS) of Drivers; Renewal of American Pyrotechnics Association (APA) Exemption...

    Science.gov (United States)

    2011-06-28

    ... will receive a tracking number. Fax: 1-202-493-2251. Mail: Docket Management Facility: U.S. Department... PO Box 319 Greenwood, MO 64034-0319... 087079 47. Walt Disney Parks and Resorts US Inc. Box...

  5. EUNA APA symposium: workshop on action, aging, physical activity and participation

    NARCIS (Netherlands)

    Hopman-Rock, M.; Erwin, T.; Rydwik, E.; Kirsten, F.; Freiberger, E.; Meeteren, N. van

    2012-01-01

    Abstract for the International Society for Aging and Physical activity's 8th World Congress on Aging and Physical Activity: A celebration of Diversity and Inclusion in Active Ageing, August 13-17 2012.

  6. Advancing Research and Practice: The Revised APA Division 30 Definition of Hypnosis.

    Science.gov (United States)

    Elkins, Gary R; Barabasz, Arreed F; Council, James R; Spiegel, David

    2015-04-01

    This article describes the history, rationale, and guidelines for developing a new definition of hypnosis by the Society of Psychological Hypnosis, Division 30 of the American Psychological Association. The definition was developed with the aim of being concise, being heuristic, and allowing for alternative theories of the mechanisms (to be determined in empirical scientific study). The definition of hypnosis is presented as well as definitions of the following related terms: hypnotic induction, hypnotizability, and hypnotherapy. The implications for advancing research and practice are discussed. The definitions are presented within the article.

  7. Guidelines for Nonsexist Language in APA Journals: Publication Manual Change Sheet 2

    Science.gov (United States)

    American Psychologist, 1977

    1977-01-01

    This second change sheet for its publication manual states the American Psychologist Association's policy on sexist language in its journals offers some general principles for journal authors to consider, and suggests some ways to avoid sexist language. (Author)

  8. Some polite applause for the 2003 APA Division 30 definition of hypnosis.

    Science.gov (United States)

    Woody, Erik; Sadler, Pamela

    The authors argue that the new definition of hypnosis by Division 30 of the American Psychological Association contains questionable information about the role of imagination in hypnosis, about the use versus omission of the word hypnosis in inductions, and about the nature of individual differences and their relation to the standardized scales. In addition, the definition appears to conflate formal and exemplar-based types of definition, and it does not seem particularly well-tuned to the interests of lay persons. The authors advance some suggestions for future definitional efforts.

  9. The Model Does Matter II: Admissions and Training in APA-Accredited Counseling Psychology Programs

    Science.gov (United States)

    Norcross, John C.; Evans, Krystle L.; Ellis, Jeannette L.

    2010-01-01

    This study collected information on the acceptance rates, admission standards, financial assistance, student characteristics, theoretical orientations, and select outcomes of American Psychological Association-accredited counseling psychology programs (99% response rate). Results are presented collectively for all 66 counseling programs as well as…

  10. Environmental diagnostic of the Bonifácio Creek, APA Jundiaí - SP

    Directory of Open Access Journals (Sweden)

    José Euclides Stipp Paterniani

    2007-11-01

    Full Text Available The growing discussion on topics related to water availability reveals the need of studies and understanding of the dynamics of this natural resource in a watershed scale. The main goal of this research was to evaluate which expedite assessments on water quality and quantity would provide a better management of the water resources of Bonifácio Creek, tributary of the Jundiaí River, aiming irrigation demand. To evaluate the water availability of that microbasin (2,98 Km² were carried out stream flow meter using triangular weir, located in the Technical School (ETE reservoir. pH, electrical conductivity, water temperature, dissolved oxygen (OD, turbidity, color, total and fecal coliforms, and nitrogen (Total, NO3, NH3 were measured in four sites (ETE entrance, reservoir, after the vegetable garden, ETE exit in twelve samplings. Results indicated that some parameters extrapolated the water standards defined for the Creek in CONAMA Resolution 357/2005, probably due the soil occupation in the basin. Also high concentrations of nitrates were verified during dry and wet seasons. However, the topographic profile, the riparian forest and a natural wetland in the Technical School sector of the basin are contributing for the water pollution abatement, as indicated by the readings on color and turbidity.

  11. Council for Accreditation of Counseling and Related Educational Programs (CACREP) or APA Doctoral Accreditation?

    Science.gov (United States)

    Sweeney, Thomas J.

    The Council for the Accreditation of Counseling and Related Educational Programs (CACREP), as a corporate affiliate of the American Association for Counseling and Development, is the accrediting agency for the world's largest association for counseling. CACREP has been in consultation with the Council on Postsecondary Accreditation (COPA) staff…

  12. Quantitative Statements in Standards of Three Accrediting Bodies: APA, CACREP, and CSWE.

    Science.gov (United States)

    Peterson, Marla P.; Turner, Janet

    The accreditation manual of the Council for Accrediation of Counseling and Related Education Programs (CACREP) contains a statement that, whenever possible, criteria for assessing standards should be qualitative rather than quantitative. The study reported in this paper was conducted to gather baseline data on the extent to which accrediting…

  13. Konsep Nilai Wajar (Fair Value) dalam Standar Akuntansi Berbasis IFRS di Indonesia Apa dan Bagaimana?

    OpenAIRE

    Heri Sukendar W

    2012-01-01

    This paper is intended to explain the use of the concept of fair value instead of book value. The accounting world in Indonesia during the last few years have made convergency implementation of new accounting standards oriented to the International Financial Reporting Standards (IFRS) issued by International Accounting Standard Boars (IASB). This new accounting standard that emphasizes the concept of fair value compared with book value concept is outdated. The use of the concept of fair value...

  14. Implementasi Tanggungjawab Sosial PT Petrokimia Gresik pada Masyarakat Lokal: Apa Kata Mereka?

    Directory of Open Access Journals (Sweden)

    I Made Narsa

    2014-12-01

    Full Text Available This study explores and analyzes in depth the impact of CRS program of PT PG on social, economic, and environment conditions of the surrounding society especially in Kelurahan Karangturi, Gresik. We interviewed informant and were supported by monographic data of the county. We found that the implementation of CSR brings positive and real impact to the social conditions of the society as it improves many aspects of the society that includes health, educations, employment, and institutional strengthening through management of bad nutrient infants, scholarships, and improvement in clean water availability and air condition.

  15. The Operational Equations of State. 5: The APA - Equation of State

    Science.gov (United States)

    2013-09-01

    2 * * * * , 1 / T T T V V T E V T E V V V T P V E dS V dE V dV T dVT E T T E V dT E V dV d...2 * * * * , S S V V S S S E S V SV S V S E V V S V S T V T E T E V dE V P V E T V dV d T V T E VT E T V T E V d dVT T V T E V

  16. Konsep Nilai Wajar (Fair Value dalam Standar Akuntansi Berbasis IFRS di Indonesia Apa dan Bagaimana?

    Directory of Open Access Journals (Sweden)

    Heri Sukendar W.

    2012-05-01

    Full Text Available This paper is intended to explain the use of the concept of fair value instead of book value. The accounting world in Indonesia during the last few years have made convergency implementation of new accounting standards oriented to the International Financial Reporting Standards (IFRS issued by International Accounting Standard Boars (IASB. This new accounting standard that emphasizes the concept of fair value compared with book value concept is outdated. The use of the concept of fair value of the difference and it turned out to be a trigger konvergency change the paradigm of the book value of a simpler, but less information is less transparent. The implementation of accounting standards konverjensi done gradually raises serious problems, this can be seen from postponed the application of PSAK 50 & PSAK 55 in the banking industry. Knowledge and experience of inadequate is a priority of fair value implementation difficulties.

  17. An overview of the major changes in the 2002 APA Ethics Code.

    Science.gov (United States)

    Knapp, Samuel; VandeCreek, Leon

    2003-06-01

    This article summarizes the major changes that were made to the 2002 Ethical Principles and Code of Conduct of the American Psychological Association. The 2002 Ethics Code retains the general format of the 1992 Ethics Code and does not radically alter the obligations of psychologists. One goal of the Ethics Committee Task Force was to reduce the potential of the Ethics Code to be used to unnecessarily punish psychologists. In addition, the revised Ethics Code expresses greater sensitivity to the needs of cultural and linguistic minorities and students. Shortcomings of the 2002 Ethics Code are discussed.

  18. Teaching Statistics in APA-Accredited Doctoral Programs in Clinical and Counseling Psychology: A Syllabi Review

    Science.gov (United States)

    Ord, Anna S.; Ripley, Jennifer S.; Hook, Joshua; Erspamer, Tiffany

    2016-01-01

    Although statistical methods and research design are crucial areas of competency for psychologists, few studies explore how statistics are taught across doctoral programs in psychology in the United States. The present study examined 153 American Psychological Association-accredited doctoral programs in clinical and counseling psychology and aimed…

  19. ECOTURISMO, GESTÃO PARTICIPATIVA E DILEMAS LOCAIS: UMA ANÁLISE NA APA DO PURAQUEQUARA

    Directory of Open Access Journals (Sweden)

    Fagno Oliveira

    2011-05-01

    Full Text Available Este artigo apresenta uma análise do contexto da gestão participativa de comunidades locais em uma área de uso sustentável prescrita no Sistema Nacional de Unidades de Conservação da Natureza (SNUC, 2000, no ato de criação, implementação e gestão dessas áreas. A pesquisa foi desenvolvida na cidade de Manaus, estado do Amazonas, em três comunidades ribeirinhas localizadas em uma Área de Proteção Ambiental em processo de implementação. A metodologia utilizada consistiu em revisão bibliográfica e utilização da técnica de observação direta intensiva. As comunidades avaliadas foram: Igarapé da Floresta, Santa Luzia e São Francisco do Mainã localizadas no rio Puraquequara. Foram entrevistadas 62 pessoas, realizando levantamento sobre “unidades de conservação, turismo, problemas locais e atuação do governo”. Os resultados obtidos apontam a necessidade de atuação do governo municipal e estadual, na execução de estratégias e planos para o conhecimento sobre áreas protegidas, conservação ambiental e participação local.

  20. Transport Research APAS (actions de preparation, d'accompagnement et du suivi)

    DEFF Research Database (Denmark)

    Leleur, Steen; Pedersen, Karsten S.; Bendtsen, Ulla

    1996-01-01

    The aim of the study, dealing with road investments evaluation, is to deliver a single, coherent approach of the full range of road projects. The study draws together, contrasts and compares evaluation procedures and fuses them into an approach to evaluation which embraces both technical performa...

  1. The Fifth Edition of the APA "Publication Manual": Why Its Statistics Recommendations Are So Controversial.

    Science.gov (United States)

    Fidler, Fiona

    2002-01-01

    Identifies deficiencies in the new edition of the American Psychological Association's "Publication Manual," drawing on interviews with some critics and other parties. These include lack of follow-through with explanations and examples of how to report the statistics now recommended. (SLD)

  2. Of Course: Prerequisite Courses for Admission into APA-Accredited Clinical and Counseling Psychology Programs

    Science.gov (United States)

    Norcross, John C.; Sayette, Michael A.; Stratigis, Katerina Y.; Zimmerman, Barrett E.

    2014-01-01

    Students often inquire about which psychology courses to complete in preparation for graduate school. This study provides data that enable students and their advisors to make research-informed decisions. We surveyed the directors of the 304 American Psychological Association-accredited doctoral programs in clinical and counseling psychology (97%…

  3. Gentlemanly Orthodoxy: Critical Race Feminism, Whiteness Theory, and the APA Manual

    Science.gov (United States)

    Thompson, Audrey

    2004-01-01

    Although often viewed as burdensome, academic writing guidelines are rarely treated as actively problematic. Even progressive scholars are unlikely to challenge the cultural assumptions or political investments of academic style guides. Yet standards regarding clarity, precision, appropriateness, sensitivity, and objectivity are not politically…

  4. Anxiety Disorders

    Science.gov (United States)

    ... in your area today. Search Now APA Resources APA Resources for Patients and Families Warning Signs of ... 2017 Become an APA Member Learn More Explore APA Psychiatrists Residents & Medical Students Patients & Families About APA ...

  5. Warning Signs of Mental Illnesses

    Science.gov (United States)

    ... Disorder Become an APA Member Learn More Explore APA Psychiatrists Residents & Medical Students Patients & Families About APA ... Psychiatric News Message from President APA Blogs Join APA General Members Residents and Fellows Medical Students International ...

  6. What Is Psychiatry?

    Science.gov (United States)

    ... Disorder Become an APA Member Learn More Explore APA Psychiatrists Residents & Medical Students Patients & Families About APA ... Psychiatric News Message from President APA Blogs Join APA General Members Residents and Fellows Medical Students International ...

  7. PARADOXOS ENTRE TAIPU DE FORA E TAIPU DE DENTRO / APA DE MARAÚ-BAHIA: TURISMO E IDENTIDADE LOCAL

    Directory of Open Access Journals (Sweden)

    Ivan Rêgo Aragão

    2011-02-01

    Full Text Available Normal 0 21 false false false PT-BR X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabela normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} O presente trabalho tem como objeto de estudo duas localidades geograficamente próximas, mas díspares em suas realidades: Taipu de Fora e de Dentro, ambas na Bahia. O objetivo foi o de realizar um estudo comparativo sobre a ocupação do espaço pelo turismo, e seus reflexos na identidade dos dois povoados. Foi realizada uma pesquisa qualitativa exploratória, primeiramente através de pesquisa bibliográfica, seguida de observação in loco e entrevistas abertas e semiestruturadas. Ainda em campo, e após a visita, buscou-se relacionar os conceitos de ‘alma do lugar’, memória, sentimento de pertença e patrimônio imaterial. A análise dos resultados foi realizada relacionando-se os relatos coletados na pesquisa exploratória, com a observação direta, buscando-se as aproximações e as diferenças na relação entre turismo, espaço e identidade. Dessa forma, a relevância deste estudo se dá ao estimular a reflexão acerca das contradições proporcionadas pela atividade turística.  

  8. Examining Harry Thaw's "brain-storm" defense: APA and ANA presidents as expert witnesses in a 1907 trial.

    Science.gov (United States)

    Pinta, Emil R

    2008-06-01

    In 1907, Harry K. Thaw, son of a railroad multi-millionaire, stood trial for shooting and killing architect Stanford White during the performance of a Broadway musical. The defense claimed that Thaw had experienced a "brain storm" causing temporary insanity. The brain-storm defense was ridiculed by professional groups, the public and the press. However, the defense experts were all respected leaders in their fields. They included five past or future presidents of the American Psychiatric Association and American Neurological Association. With no standard terminology in 1907, the much-maligned brain-storm diagnosis was in many respects an appropriate term for a sudden, drastic and temporary defect of reasoning having a physical cause. In spite of a strict test for mental nonresponsibility, the jury did not return a murder verdict.

  9. What Is the Role and Importance of the Revised AERA, APA, NCME "Standards for Educational and Psychological Testing"?

    Science.gov (United States)

    Plake, Barbara S.; Wise, Lauress L.

    2014-01-01

    With the 2014 publication of the 5th revision of the "Standards for Educational and Psychological Testing," the cochairs of the Joint Committee for the revision process were asked to consider the role and importance of the "Standards" for the educational testing community, and in particular for members of the National Council…

  10. [The evolution of ethical standards in the practice of psychology: a reflection on the APA Code of Ethics].

    Science.gov (United States)

    Sabourin, M

    1999-04-01

    After briefly describing the need for ethics in the development of professional regulation and analyzing the historical emergence of codes of ethics, the goal of this paper is to scrutinize the process by which the American Psychological Association developed its own Code of Ethics and proceeded to revise it periodically. Different lessons can be derived from these efforts and from the criticisms that were formulated. The need for international standards in professional and research ethics is then considered, and the results of a recent study on this subject are presented. Five major conclusions can be derived from the preceding analysis: (1) Codes of ethics can help professional recognition by stressing the importance given to the protection of the public, (2) the development of a code of ethics is usually related to the advancement of professional practice, (3) ethical standards should be in tune with the cultural values and the belief system of a given community, (4) a well-balanced code should incorporate both general aspirational principles and enforceable standards, and (5) the method used to define principles and standards should be empirically based.

  11. Applying the APA/AERA/NCME "Standards": Evidence for the Validity and Reliability of Three Statewide Teaching Assessment Instruments.

    Science.gov (United States)

    Rothenberg, Lori; Hessling, Peter A.

    The statewide teaching performance assessment instruments being used in Georgia, North Carolina, and Florida were examined. Forty-one reliability and validity studies regarding the instruments in use in each state were collected from state departments and universities. Georgia uses the Georgia Teacher Performance Assessment Instrument. North…

  12. Training and education in religion/spirituality within APA-accredited clinical psychology programs: 8 years later.

    Science.gov (United States)

    Schafer, Rachel M; Handal, Paul J; Brawer, Peter A; Ubinger, Megan

    2011-06-01

    This study was a follow up investigation of Brawer et al.'s (Prof Psychol Res Pr 33(2):203-206, 2002) survey of education and training of clinical psychologists in religion/spirituality. Directors of clinical training were surveyed to determine whether changes had occurred in the coverage of religion and spirituality through course work, research, supervision, and in the systematic coverage of the content area. Results indicated an increased coverage in the areas of supervision, dedicated courses, inclusion as part of another course, and research. There was no increase in systematic coverage, but significantly more programs provided at least some coverage. The current study also assesses other areas of incorporation as well as directors' opinions regarding the importance of religion/spirituality in the field of psychology.

  13. Exploring the APA Fifth Edition "Publication Manual"'s Impact on the Analytic Preferences of Journal Editorial Board Members.

    Science.gov (United States)

    Capraro, Mary Margaret; Capraro, Robert M.

    2003-01-01

    Studied the reporting preferences of editorial board members of four scholarly journals in education and psychology with regard to analytic practices in the fifth edition of the American Psychological Association "Publication Manual." Responses of 106 board members show the movement toward reform in research reporting practices. (SLD)

  14. MCM3AP,a Novel HBV Integration Site in Hepatocellular Carcinoma and Its Implication in Hepatocarcinogenesis

    Institute of Scientific and Technical Information of China (English)

    王晶; 林菊生; 常莹; 黎培元; 杨玉珍

    2010-01-01

    A novel HBV integration site involved in hepatocarcinogenesis was investigated. The HBV DNA integration sites were detected by Alu-PCR in hepatocellular carcinoma tissues, matched surrounding liver tissues in 30 patients with hepatitis B-related hepatocellular carcinoma (HCC) and 3 cases of normal liver tissues. The integration sites and flanking sequences in human genome were sequenced and blasted, and the expression of integrated HBV genes was determined by reverse transcriptase-polymerase chain reaction ...

  15. Form and Style: Theses, Reports, Term Papers. Eighth Edition. Up-to-Date Information on Chicago, MLA, and APA Documentation.

    Science.gov (United States)

    Campbell, William Giles; And Others

    The eighth edition of this manual, which incorporates recent changes in bibliographical format made by "The Chicago Manual of Style" and the Modern Language Association of America, provides guidance to writers of research papers and reports in college, graduate school, business, government, and the professions. The review of the…

  16. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Sign In Join General Residents and Fellows Medical Students International close menu Psychiatrists Education Practice Cultural Competency Awards & ... Join APA General Members Residents and Fellows Medical Students International Become a Fellow APA Sites APA Publishing APA ...

  17. What Is Psychiatry?

    Medline Plus

    Full Text Available About APA APA's Vision, Mission, Values, and Goals Meet Our Organization Read APA Organization Documents and Policies Work at APA Contact Us Newsroom News Releases Message from ...

  18. What Is Psychiatry?

    Medline Plus

    Full Text Available ... PTSD) S Schizophrenia Sleep Disorders Somatic Symptom Disorder Specific Learning Disorder Become an APA Member Learn More Explore APA Psychiatrists Residents & Medical Students Patients & Families About APA Work At APA Annual Meeting Newsroom News Releases Psychiatric ...

  19. Best practices and improved capacities in the field of physical acitivty and older adults: results of two projects of the EUNA APA network

    NARCIS (Netherlands)

    Tak, E.

    2012-01-01

    Abstract for the International Society for Aging and Physical activity's 8th World Congress on Aging and Physical Activity: A celebration of Diversity and Inclusion in Active Ageing, August 13-17 2012.

  20. Suggestions from Representatives of the International Language Testing Association for Revision of the "AERA/APA/NCME Standards for Educational and Psychological Testing."

    Science.gov (United States)

    Stansfield, Charles W.; Spolsky, Bernard

    The International Language Testing Association has some 250 members in 15 countries. Most are specialists in the testing of second language skills, with a special interest in performance assessment because of the testing of speaking and writing performance that is critical to second language skills assessment. The association believes that certain…

  1. Guía para la Presentación de Trabajos Científicos Bajo el Estándar APA en la Universidad EAN

    OpenAIRE

    Argüelles Pabón, Denise Caroline; Calderón Rojas, Jacqueline; Ortega, Sandra Constanza; Patiño, Juan Carlos; de la Hoz, Gerardo Augusto; Cáceres, Omar Antonio; Clavijo, Sandra Bibiana; Correal, María Clara; Fresneda, Laura Cediel

    2013-01-01

    Esta es una interpretación del Manual de Publicaciones de la American Psychological Association, tercera edición en español y sexta en inglés, para el contexto de la Universidad EAN. El trabajo tiene como objetivo, establecer los lineamientos para la adecuada presentación de trabajos científicos de calidad nacional e internacional, entendidos como artículos científicos, trabajos de grado, resultados de investigación y tesis doctorales.

  2. Búsqueda de bibliografía científica en línea : Armado de referencias con normas APA

    OpenAIRE

    Gómez, María Florencia

    2016-01-01

    En el trabajo académico y profesional del psicólogo, es central la presentación de propuestas de trabajo y de investigación. Por ello, un paso necesario es saber buscar y organizar la bibliografía académica para armar su fundamentación. Esta ficha tiene el propósito de introducir algunas claves para orientar la búsqueda bibliográfica y recuperar contenido académico evaluado por pares, de relevancia en el campo de trabajo del psicólogo. Asimismo, se realiza una síntesis de las formas de citado...

  3. Evaluation of vitamin D receptor (VDR) gene polymorphisms (FokI, TaqI and ApaI) in a family with dentinogenesis imperfecta.

    Science.gov (United States)

    Ulucan, K; Akyüz, S; Ozbay, G; Pekiner, F N; Güney, A Ilter

    2013-01-01

    Dentinogenesis imperfecta Type II (DGI-II) is a condition inherited as an autosomal dominant trait and characterized by abnormal dentine structure affecting both the primary and secondary dentitions. The genetic etiology of the disease still remains unclear, suggesting a genetically heterogeneous background. The aim of this study is to manifest briefly DGI-II and to investigate the association between BsmI, TaqI and FokI polymorphisms of Vitamin D receptor (VDR) gene and dentinogenesis imperfecta type II in a Turkish family by PCR-RFLP methodology. The affected mother and her two affected daughters were bb for BsmI polymorphism, whereas her unaffected son and her husband were Bb for the same polymorphism. One of the affected children was tt, the rest of the family were Tt for TaqI polymorphism, and all of the enrolled subjects were FF for FokI polymorphism. As a conclusion, BsmI polymorphism bb seems to be associated with (DGI-II), but should be examined in larger numbers in order to be considered as a risk factor.

  4. 基于膜分离过程的6-APA生产技术%Technology of Manufacturing 6-APA Based on Membrane Separation Process

    Institute of Scientific and Technical Information of China (English)

    何旭敏; 夏海平; 胡建华; 蓝伟光

    2002-01-01

    该项目设计了适当的纳滤膜浓缩工艺,以提高6-APA生成率,6-APA成品的平均克分子收率达90.18%;设计了醋酸丁酯-乙醇结晶工艺;选择了合适的溶媒体系及控制pH值以确保6-APA的质量;对溶媒及副产品苯乙酸进行了回收利用,降低了成本,减少了环境污染.纳滤膜分离技术是使低浓度裂解高浓度结晶得以实现的关键技术.用于100t 6-APA生产线上取得良好效果.

  5. Society for Health Psychology (APA Division 38) and Society of Behavioral Medicine joint position statement on the Medicare Diabetes Prevention Program.

    Science.gov (United States)

    Fitzpatrick, Stephanie L; Wilson, Dawn K; Pagoto, Sherry L

    2017-01-31

    Beginning in January 2018, the Centers for Medicare and Medicaid Services (CMS) plans to cover the Diabetes Prevention Program (DPP), also referred to as Medicare DPP. The American Psychological Association Society for Health Psychology (SfHP) and the Society for Behavioral Medicine (SBM) reviewed the proposed plan. SfHP and SBM are in support of the CMS decision to cover DPP for Medicare beneficiaries but have a significant concern that aspects of the proposal will limit the public health impact. Concerns include the emphasis on weight outcomes to determine continued coverage and the lack of details regarding requirements for coaches. SfHP and SBM are in strong support of modifications to the proposal that would remove the minimum weight loss stipulation to determine coverage and to specify type and qualifications of "coaches."

  6. Applicability of Asphalt Pavement Analyzer APA%沥青路面分析仪APA的适用性评价

    Institute of Scientific and Technical Information of China (English)

    孙永军; 何锐

    2009-01-01

    指出沥青混凝土路面分析仪APA是一种以沥青混合料轮辙深度为主要评测指标的室内加速加载测试装置,通过对前人研究经验的总结,介绍了APA试验条件的确定过程,对其适用性进行了分析和总结,以推动国内关于APA在预测沥青混合料抗车辙性能方面的应用和研究.

  7. 基于APA的沥青混合料水稳性试验研究%Experimental investigation of cement stability of bituminous mixture based on APA

    Institute of Scientific and Technical Information of China (English)

    李亿龙

    2007-01-01

    分析了几种评价沥青混合料水稳性的方法,比较了其特点以及存在的问题,通过对不同级配的沥青混合料进行APA浸水车辙试验,得出APA浸水车辙试验评价沥青混合料的水稳性能较好模拟实际路面发生水损害的结论.

  8. APA Summit on Medical Student Education Task Force on Informatics and Technology: Learning about Computers and Applying Computer Technology to Education and Practice

    Science.gov (United States)

    Hilty, Donald M.; Hales, Deborah J.; Briscoe, Greg; Benjamin, Sheldon; Boland, Robert J.; Luo, John S.; Chan, Carlyle H.; Kennedy, Robert S.; Karlinsky, Harry; Gordon, Daniel B.; Yager, Joel; Yellowlees, Peter M.

    2006-01-01

    Objective: This article provides a brief overview of important issues for educators regarding medical education and technology. Methods: The literature describes key concepts, prototypical technology tools, and model programs. A work group of psychiatric educators was convened three times by phone conference to discuss the literature. Findings…

  9. APA Summit on Medical Student Education Task Force on Informatics and Technology: Steps to Enhance the Use of Technology in Education through Faculty Development, Funding and Change Management

    Science.gov (United States)

    Hilty, Donald M.; Benjamin, Sheldon; Briscoe, Gregory; Hales, Deborah J.; Boland, Robert J.; Luo, John S.; Chan, Carlyle H.; Kennedy, Robert S.; Karlinsky, Harry; Gordon, Daniel B.; Yellowlees, Peter M.; Yager, Joel

    2006-01-01

    Objective: This article provides an overview of how trainees, faculty, and institutions use technology for acquiring knowledge, skills, and attitudes for practicing modern medicine. Method: The authors reviewed the literature on medical education, technology, and change, and identify the key themes and make recommendations for implementing…

  10. Effects of diagnosis on treatment recommendations in chronic insomnia--a report from the APA/NIMH DSM-IV field trial.

    Science.gov (United States)

    Buysse, D J; Reynolds, C F; Kupfer, D J; Thorpy, M J; Bixler, E; Kales, A; Manfredi, R; Vgontzas, A; Stepanski, E; Roth, T; Hauri, P; Stapf, D

    1997-07-01

    The objective of this study was to determine whether sleep specialists and nonspecialists recommend different treatments for different insomnia diagnoses according to two different diagnostic classifications. Two hundred sixteen patients with chronic insomnia at five sites were each interviewed by two clinicians: one sleep specialist and one nonsleep specialist. All interviewers indicated diagnoses using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV); sleep specialists also indicated diagnoses according to the International Classification for Sleep Disorders (ICSD). Interviewers then indicated how strongly they would recommend each item in a standard list of treatment and diagnostic interventions for each patient. We examined differences in treatment recommendations among the six most common DSM-IV diagnoses assigned by sleep specialists at different sites (n = 192), among the six most common ICSD diagnoses assigned by sleep specialists at different sites (n = 153), and among the six most common DSM-IV diagnoses assigned by nonspecialists at different sites (n = 186). In each analysis, specific treatment and polysomnography recommendations differed significantly for different diagnoses, using either DSM-IV or ICSD criteria. Conversely, different diagnoses were associated with different rank orderings of specific treatment and diagnostic recommendations. Sleep specialist and nonspecialist interviewers each distinguished treatment recommendations among different diagnoses, but in general, nonspecialists more strongly recommended medications and relaxation treatments. Significant site-related differences in treatment recommendations also emerged. Differences in treatment recommendations support the distinction between different DSM-IV and ICSD diagnoses, although they do not provide formal validation. Site-related differences suggest a lack of consensus in how these disorders are conceptualized and treated.

  11. El enfoque sistémico: aplicación al subsector de agua potable y alcantarillado (A.P.A.

    Directory of Open Access Journals (Sweden)

    Jorge E. Triviño M.

    2011-12-01

    Full Text Available Al presentar en este documento una síntesis de los principios básicos del análisis de sistemas y su aplicación al sector de agua potable y saneamiento, se desea contribuir en forma práctica a la divulgación y aplicación de una ciencia relativamente joven que permite mejorar cada vez más las organizaciones y su administración, sin causar traumatismos ni ocasionar resistencias al cambio deseado, en beneficio de la salud del hombre.

  12. 28 CFR 42.208 - Notice of noncompliance.

    Science.gov (United States)

    2010-07-01

    ... Act (APA) if: (1) The agency gives all interested parties opportunity for— (i) The submission and... consistent with the APA, it shall presume the APA procedures were applied, and send notification under §...

  13. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Releases Message from the President Reporting on Mental Health Conditions APA Blogs Annual Meeting Advocacy & APAPAC APA ... APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Sign In Join General Residents and Fellows Medical ...

  14. 78 FR 17661 - Proposed Reissuance of a General NPDES Permit for Oil and Gas Exploration Facilities in the...

    Science.gov (United States)

    2013-03-22

    ... agency ``is required ] by section 553 of the Administrative Procedure Act (APA), or any other law, to..., under the APA and thus not subject to APA rulemaking requirements or the RFA. Notwithstanding...

  15. 78 FR 77122 - Proposed Modification of a General NPDES Permit for Small Suction Dredging-Permit Number IDG-37-0000

    Science.gov (United States)

    2013-12-20

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... permits are permits, not rulemakings, under the APA and thus not subject to APA rulemaking requirements...

  16. 77 FR 123 - Final Reissuance of General NPDES Permits (GP) for Facilities Related to Oil and Gas Extraction

    Science.gov (United States)

    2012-01-03

    ... the agency ``is required by section 553 of the Administrative Procedure Act (APA), or any other law... rulemakings, under the APA and thus not subject to APA rulemaking requirements or the RFA....

  17. 75 FR 65483 - Proposed Reissuance of General NPDES Permits (GP) for Alaskan Medium-Size Suction Dredging...

    Science.gov (United States)

    2010-10-25

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... general permits are permits, not rulemakings, under the APA and thus not subject to APA...

  18. Cd, Cr AND Al DETERMINATION IN FISH TISSUE FROM GELADO RIVER/APA, CARAJÁS-PA FOREST = DETERMINAÇÃO DE Cd, Cr E Al EM TECIDO DE PEIXES PROVENIENTES DO RIO GELADO/APA, FLORESTA DE CARAJÁS-PA

    Directory of Open Access Journals (Sweden)

    Bruno de Cássio Veloso Barros

    2010-01-01

    Full Text Available The fish on the Gelado River are subject to the contamination of heavy metals derived from waste one of the largest mining companies in the world, which uses the river as receptacle of water for washing ore. The study objective was to evaluate the Cd, Cr and Al presence in tissue samples of fish species: piranha (Serrasalmus spp., branquinha (Potamorhina spp. and tucunaré (Cichla spp. collected in the Gelado River, a view to preserve the population health that consumes these species. The samples were dissolved using wet opening and microwave, and metals analyzed by ICPAES (inductively coupled plasma atomic emission spectroscopy. Al, Cd and Cr were found in high concentrations in all evaluated species, representing a major risk to public health. The elements Al and Cr presented excellent correlation in piranha species. Statistical analysis revealed the influence of anthropogenic activity in the region, leading to the need for future studies to verify the dynamics of correlation with other trace elements. The analysis shows that the elements are being absorbed by fish and the concentrations of some elements can damage the health of consumers of these species. = Os peixes existentes no rio Gelado estão submetidos ao aporte de metais pesados, oriundos de rejeitos de uma das maiores mineradoras do mundo, que utiliza o rio como receptáculo de água de lavagem de minério. O trabalho teve como objetivo avaliar a presença de Cd, Cr e Al no tecido de peixes das espécies: piranha (Serrasalmus spp., branquinha (Potamorhina spp. e tucunaré (Cichla spp. coletadas no rio Gelado, tendo em vista a preservação da saúde da população que consome estas espécies. As amostras foram solubilizadas usando abertura úmida e forno de microondas, e os metais analisados através do ICPAES (espectrometria de emissão atômica com plasma indutivamente acoplado. Al, Cd e Cr foram encontrados em altas concentrações, em todas as espécies avaliadas, representando um grande risco à saúde pública. Os elementos Al e Cr apresentaram excelentes correlações na espécie piranha. As análises estatísticas demonstram a influência da ação antrópica na região, levando a necessidade de futuros estudos para a verificação da dinâmica de correlação com outros elementos traços. As análises mostram que os elementos estão sendo absorvidos pelos peixes, e que os níveis de concentração de alguns elementos podem causar danos à saúde da população consumidora destas espécies.

  19. What Is Psychiatry?

    Medline Plus

    Full Text Available ... O Obsessive-Compulsive Disorder P Personality Disorders Posttraumatic Stress Disorder (PTSD) ... Families About APA Work At APA Annual Meeting Newsroom News Releases Psychiatric ...

  20. What Is Psychiatry?

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    Full Text Available ... I Intellectual Disability O Obsessive-Compulsive Disorder P Personality Disorders Posttraumatic Stress Disorder ... & Medical Students Patients & Families About APA Work At APA Annual ...

  1. 78 FR 26504 - Women-Owned Small Business Federal Contract Program

    Science.gov (United States)

    2013-05-07

    ... Administrative Procedures Act (APA) and SBA regulations. 5 U.S.C. 553 and 13 CFR 101.108. The APA provides an... APA requires that ``publication or service of a substantive rule shall be made not less than 30 days... effective the same day it is published in the Federal Register. The purpose of the APA provision is...

  2. 75 FR 8645 - Public Meetings on the Development of the Forest Service Land Management Planning Rule

    Science.gov (United States)

    2010-02-25

    ... Procedure Act (NEPA/APA) processes. Any comments you wish to be considered as part of the formal NEPA/APA... Administrative Procedure Act (NEPA/APA) processes. Any comments you wish to be considered as part of the formal NEPA/APA process must be made by you in writing during the appropriate comment period....

  3. 78 FR 61153 - Post-Employment Conflict of Interest Regulations; Exempted Senior Employee Positions

    Science.gov (United States)

    2013-10-03

    ... (APA). Further, under 5 U.S.C. 553(b)(3)(A), notice and comment rulemaking requirements do not apply to... comment requirements of the APA do not apply here. Even if this rulemaking were subject to APA proposed... comment requirements of the APA. The codification of OGE's revocation of exempted positions is...

  4. 42 CFR 137.309 - How are NEPA and NHPA obligations typically enforced?

    Science.gov (United States)

    2010-10-01

    ... may only be filed in Federal court under the provisions of the APA, 5 U.S.C. 701-706. Under the APA, a... the court's views for those of the agency. Jury trials and civil discovery are not permitted in APA... injunctive relief to the interested party. No money damages or fines are permitted in APA proceedings....

  5. 77 FR 55695 - Approval and Promulgation of Implementation Plans; Virginia; Revisions to the State...

    Science.gov (United States)

    2012-09-11

    ...'' exemption in the Administrative Procedure Act (APA). This exemption in the APA authorizes agencies to... delayed effective date otherwise provided for in the APA. DATES: This action is effective September 11... Procedure Act (APA). This exemption authorizes agencies to dispense with public participation and...

  6. 78 FR 26690 - Hours of Service (HOS) of Drivers; Application for Renewal and Expansion of American Pyrotechnics...

    Science.gov (United States)

    2013-05-07

    ... Expansion of American Pyrotechnics Association (APA) Exemption From the 14-Hour Rule During Independence Day... Association (APA) has requested a renewal of its exemption for 48 APA member-companies from FMCSA's regulation..., and the expansion of its exemption to 10 additional carriers. The APA was previously granted...

  7. El artículo científico para revista académica: Pautas para su planificación y edición de acuerdo con el modelo APA

    Directory of Open Access Journals (Sweden)

    María Elena Camacho Villalobos

    2014-01-01

    Full Text Available A partir de la experiencia de las autoras como directoras y editoras de revistas académicas, en comités editoriales, en arbitrajes de textos, en cursos impartidos para la redacción de artículos y sobre la escritura en general, y en la revisión filológica, se propone este artículo. En estas experie ncias han detectado diversas dificultades en la escritura de artículos, por lo cual plantean los indicadores de calidad e información pertinente para la escogencia del medio en que se quiere publicar; formato general, modalidades y partes constituyentes de l artículo; la construcción de la cohesión y la coherencia; la planificación del texto y la elaboración de las paráfrasis. Bosquejan elementos que se deben revisar antes de enviar el artículo, así como estrategias para gestionar la publicación en la revist a. Con ello, atienden detalles que tienen que ver con un asunto pragmático y formal. La síntesis y el análisis constituyen herramientas para la elaboración de la paráfrasis, por tanto, su abordaje se ha considerado relevante debido a que facilitan el acopi o de información de diversas fuentes y su adecuado empleo en el documento propio. Recalcan la noción de que escribir es un acto comunicativo en el cual se debe colaborar con los potenciales lectores o lectoras con un texto cohesionado, coherente, conciso y claro. Este constituye una propuesta de lingüística aplicada a la construcción del texto académico, de provecho para diversas disciplinas.

  8. Diversidade e uso de recursos medicinais do carrasco na APA da Serra da Ibiapaba, Piauí, Nordeste do Brasil Diversity and use of medicinal resources of "carrasco" in the EPA of Serra da Ibiapaba, Piauí, Northeast Brazil

    Directory of Open Access Journals (Sweden)

    E.M.F. Chaves

    2012-01-01

    Full Text Available O presente estudo foi realizado na Área de Proteção Ambiental da Serra da Ibiapaba no município de Cocal, Piauí. Objetivou-se realizar o levantamento das plantas utilizadas pela comunidade, das partes usadas, das indicações, das formas de uso e de administração dessas plantas. Foram realizadas 80 entrevistas com 100% dos moradores de notório saber, residentes no município que utilizavam e/ou comercializavam plantas de uso medicinal. Para definição da amostra utilizou-se o método de bola de neve. Em incursões guiadas por membros da comunidade, foram coletadas as etnoespécies citadas. Após essa etapa, as espécies foram identificadas em laboratório e calculado o Fator de Consenso dos Informantes (FCI para cada categoria de doença. O material foi incorporado ao acervo do Herbário Graziela Barroso (TEPB/UFPI. Foram identificadas 76 espécies, distribuídas em 61 gêneros e 36 famílias. Sobresairam-se Leguminosae com 22 espécies (28,9%, seguida por Euphorbiaceae com 6 (7,8%, e Solanaceae 4 (5,2%. Os gêneros Croton L. e Hymenaea L. obtiveram o maior destaque, somando 8 (10,5% do total de espécies. As espécies mais presentes nas indicações de uso foram Ximenia americana com 14 (5,9%, Tabebuia impetiginosa com 9 (3,9% e Anacardium occidentale com 7 (2,9%. Observou-se que 80,5% dos entrevistados tinham mais de 50 anos e residiam no município a mais de 20 anos, sendo que 70% possuíam apenas ensino fundamental incompleto e 20 % eram analfabetos. Houve maior consenso entre os informantes para tratamento das doenças do sistema respiratório (0,66 e do aparelho digestório (0,65. A maioria das indicações de usos 81 (34,17% relatados para 28 (36,8% das espécies visavam curar males do sistema respiratório, tais como asma, bronquite, gripe, inflamação na garganta, pneumonia e sinusite. Para o preparo dos remédios, as partes mais utilizadas foram as cascas (30,5%, as folhas (29,4% e as raízes (12,6%. As preparações mais comuns foram os chás, garrafadas e lambedores, administrados por via oral. Os resultados sinalizaram para a importância do potencial bioativo da vegetação do carrasco.The present study was carried out in the Environmental Protection Area of Serra da Ibiapaba, in Cocal Municipality, Piauí. The study aimed to perform a survey of the plants used by the community, including used parts, recommended use, forms of use and administration of these plants. A total of 80 interviews were done with 100% of denizens with noteworthy knowledge who lived in that municipality and used and/or commercialized plants of medicinal use. To define the sample the snowball method was adopted. In tours guided by members of the community, the cited ethnospecies were collected. After this stage, the species were identified in the laboratory and the Informant Consensus Factor (ICF was calculated for each disease category. The material was incorporated in the collection of Herbarium Graziela Barroso (TEPB/UFPI. A total of 76 species were identified, distributed into 61 genera and 36 families. Leguminosae was the major family with 22 species (28.9%, followed by Euphorbiaceae with 6 (7.8% and Solanaceae with 4 (5.2%. Croton L. and Hymenaea L. were the most important genera, comprising 8 (10.5% of the total species. The species most commonly recommended for medicinal use were Ximenia americana with 14 (5.9%, Tabebuia impetiginosa with 9 (3.9% and Anacardium occidentale with 7 (2.9%. The age of 80.5% of the interviewees was over 50 years and they had been living in the municipality for more than 20 years, while 70% had only incomplete elementary education and 20% were illiterate. There was greater consensus among the informants for treatment of respiratory diseases (0.66 and problems of the digestive system (0.65. The most common recommendation of use, 81 (34.17%, reported for 28 (36.8% of the species, aimed to cure problems of the respiratory system, such as asthma, bronchitis, influenza, inflammation of the throat, pneumonia, and sinusitis. In the preparation of medicines, the parts most commonly used were the bark (30.5%, the leaves (29.4% and the roots (12.6%. The most common preparations were tea, balm and lickers, administered orally. The results indicated the importance of the bioactive potential of "carrasco" vegetation.

  9. 基于APA车辙深度的AC-5沥青混合料体积参数的标准%Volumetric Parameter Standard of AC-5 Asphalt Mixture Based on APA Rutting Depth

    Institute of Scientific and Technical Information of China (English)

    李闯民; 王涛

    2015-01-01

    通过总结国内外应用AC-5的级配,结合规范级配提出了AC-5试验级配范围.用石灰岩和花岗岩集料设计出36种薄层AC-5沥青混合料,通过APA车辙试验对混合料性能进行分析,分析发现很多高温抗车辙性能优异的混合料体积参数并不符合我国规范AC-5沥青混合料体积参数标准,同时我国规范AC-5沥青混合料体积参数标准不完善,也缺少实体工程应用检验.鉴于此在APA车辙试验基础上分析修正AC-5沥青混合料体积参数标准.

  10. Intervenção em fisioterapia, baseada no conceito de Bobath, consegue influenciar a relação neural entre o membro superior e o membro inferior, na linha temporal dos APAS's?

    OpenAIRE

    Gomes, Joana Cristina Rodrigues

    2016-01-01

    Introdução: A atividade de músculos e /ou grupos musculares que se ativam de forma estereotipada no decorrer de tarefas funcionais continua pouco compreendida nos indivíduos pós acidente vascular encefálico (AVE). A relação neural atípica entre o membro inferior (MI) e o membro superior (MS) expressa-se frequentemente através de um predomínio da atividade extensora no MI associada a componentes flexores no MS. Objectivo(s): Face ao exposto, importa perceber se em sujeitos com componente flexo...

  11. Survey of vegetation and its diametric distribution in an area of cerrado sensu stricto and riparian forest fragment at Dois Irmãos stream in the Area of Environmental Protection (APA of Cafuringa, Federal District, Brazil.

    Directory of Open Access Journals (Sweden)

    José Elias de Paula

    2009-09-01

    Full Text Available All individual trees with a diameter at breast height (DBH of over 5cm, as well as the natural succession, were identified in 2,500m2 of the savannah (cerrado sensu stricto area and in 5,000m2 of the “Dois Irmãos” riparian forest vegetation (15º30’19”S and 48º06’18”W. The floristic composition of the cerrado sensu stricto was composed by 100 trees distributed in 25 species, and the riparian forest consisted of 155 trees distributed in 55 species. The natural regeneration was formed with 211 and 287 individuals in the cerrado sensu stricto and riparian forest distributed into 38 and 55 species respectively. The basal areas of the trees occupied 3.40m2.ha-1 in the cerrado sensu stricto and 5.08m2.ha-1 in the riparian forest. The diametric distribution curves for both plant communities, adjusted by the Meyers equation, demonstrated a typical tendency of reversed-J shape with strongly antropic action in the 11 to 17cm diametric classes.

  12. Application of ultrafiltration technique in the short-cut technology of 6-APA%超滤技术在6-APA直通工艺中的应用

    Institute of Scientific and Technical Information of China (English)

    高建军; 齐志良

    2008-01-01

    6-APA直通车工艺是指青霉素发酵液经过滤、乙酸丁酯提取、脱色、脱酯得到青霉素盐的水溶液,然后经酶裂解、萃取、结晶,得到6-APA成品.由于青霉素滤液中含有大量可溶性蛋白质很难除去,给6-APA直通工艺的应用带来了困难.本文使用Hyflux截留分子量为1×103的中空纤维超滤膜除去青霉素滤液中大部分蛋白类杂质,省去原工艺中破乳剂和丁醇的使用,产品的总收率较对照提高4.6%.超滤处理装置投入运行后1、2年即可收回投资.

  13. 基于APAS影像分析的篮球中距离跳投技术分析研究%Technique Analysis of Basketball Mid Distance Jump Shot Based on APAS Image

    Institute of Scientific and Technical Information of China (English)

    樊六东; 丁洪福

    2011-01-01

    跳投是现代篮球用的最多的投篮方式,本研究用摄影机以6 0 HZ抓取中国矿业大学男子篮球队参加过2005-2009年CUBA比赛中司职前锋及后卫的10名队员为研究对象,实验利用队员在罚球线位置做中距离跳投影像为基础,通过ArielPerformance Analysis System(APAS)进行2 D动作分析,并对收集的各分期占动作时间比例、球离手时机、球离手角度与命中率等运动学参数以叙述统计、单因子变异数分析、皮尔逊积差相关进行了统计分析,研究结论为篮球中距离跳投技术的训练与研究打下了一定基础。%Jumper shot is the most widely shooting used by basketball players.Two-dimensional video techniques(6 0 HZ)were used to obtain images of basketball jump shots from free throw line(n=10),as performed by 10 players of China University of Mining men's basketball team participated in the 2005-2009 competition of the functional CUBA striker and defender.The collected data were analyzed by one-way ANOVA and person product-moment correlation.A mid-range jump shot basketball skills training and research laid has come to conclusion.

  14. The Parallel SM- APA Algorithm for Solving Eigenvalue Problem of Symmetric Matrices%解对称矩阵特征值问题的并行SM-APA算法

    Institute of Scientific and Technical Information of China (English)

    崔向照

    2004-01-01

    在二分法和APA算法的基础上,给出了一种求实对称矩阵特征值问题的并行SM-APA算法,理论分析和在PVM下的数值结果表明,我们的算法比二分法快,而且有较高的加速比.

  15. Clinical diagnoses in 216 insomnia patients using the International Classification of Sleep Disorders (ICSD), DSM-IV and ICD-10 categories: a report from the APA/NIMH DSM-IV Field Trial.

    Science.gov (United States)

    Buysse, D J; Reynolds, C F; Kupfer, D J; Thorpy, M J; Bixler, E; Manfredi, R; Kales, A; Vgontzas, A; Stepanski, E; Roth, T

    1994-10-01

    Three diagnostic classifications for sleep disorders have been developed recently: the International Classification of Sleep Disorders (ICSD), the Diagnostic and Statistical Manual, 4th edition (DSM-IV), and the International Classification of Diseases, 10th edition (ICD-10). No data have yet been published regarding the frequency of specific diagnoses within these systems or how the diagnostic systems relate to each other. To address these issues, we examined clinical sleep disorder diagnoses (without polysomnography) in 257 patients (216 insomnia patients and 41 medical/psychiatric patients) evaluated at five sleep centers. A sleep specialist interviewed each patient and assigned clinical diagnoses using ICSD, DSM-IV and ICD-10 classifications. "Sleep disorder associated with mood disorder" was the most frequent ICSD primary diagnosis (32.3% of cases), followed by "Psychophysiological insomnia" (12.5% of cases). The most frequent DSM-IV primary diagnoses were "Insomnia related to another mental disorder" (44% of cases) and "Primary insomnia" (20.2% of cases), and the most frequent ICD-10 diagnoses were "Insomnia due to emotional causes" (61.9% of cases) and "Insomnia of organic origin" (8.9% of cases). When primary and secondary diagnoses were considered, insomnia related to psychiatric disorders was diagnosed in over 75% of patients. The more narrowly defined ICSD diagnoses nested logically within the broader DSM-IV and ICD-10 categories. We found substantial site-related differences in diagnostic patterns. These results confirm the importance of psychiatric and behavioral factors in clinicians' assessments of insomnia patients across all three diagnostic systems. ICSD and DSM-IV sleep disorder diagnoses have similar patterns of use by experienced clinicians.

  16. El artículo científico para revista académica: Pautas para su planificación y edición de acuerdo con el modelo APA

    Directory of Open Access Journals (Sweden)

    María Elena Camacho Villalobos

    2014-07-01

    Full Text Available A partir de la experiencia de las autoras como directoras y editoras de revistas académicas, en comités editoriales, en arbitrajes de textos, en cursos impartidos para la redacción de artículos y sobre la escritura en general, y en la revisión filológica, se propone este artículo. En estas experiencias han detectado diversas dificultades en la escritura de artículos, por lo cual plantean los indicadores de calidad e información pertinente para la escogencia del medio en que se quiere publicar; formato general, modalidades y partes constituyentes del artículo; la construcción de la cohesión y la coherencia; la planificación del texto y la elaboración de las paráfrasis. Bosquejan elementos que se deben revisar antes de enviar el artículo, así como estrategias para gestionar la publicación en la revista. Con ello, atienden detalles que tienen que ver con un asunto pragmático y formal. La síntesis y el análisis constituyen herramientas para la elaboración de la paráfrasis, por tanto, su abordaje se ha considerado relevante debido a que facilitan el acopio de información de diversas fuentes y su adecuado empleo en el documento propio. Recalcan la noción de que escribir es un acto comunicativo en el cual se debe colaborar con los potenciales lectores o lectoras con un texto cohesionado, coherente, conciso y claro. Este constituye una propuesta de lingüística aplicada a la construcción del texto académico, de provecho para diversas disciplinas.

  17. El artículo científico para revista académica: Pautas para su planificación y edición de acuerdo con el modelo APA

    OpenAIRE

    María Elena Camacho Villalobos; Marta Eugenia Rojas Porras; Lillyam Rojas Blanco

    2014-01-01

    A partir de la experiencia de las autoras como directoras y editoras de revistas académicas, en comités editoriales, en arbitrajes de textos, en cursos impartidos para la redacción de artículos y sobre la escritura en general, y en la revisión filológica, se propone este artículo. En estas experiencias han detectado diversas dificultades en la escritura de artículos, por lo cual plantean los indicadores de calidad e información pertinente para la escogencia del medio en que se quiere publicar...

  18. Revisión acerca de las normas para la presentación de referencias bibliográficas según el estilo de la American Psychological Association (APA

    Directory of Open Access Journals (Sweden)

    Cristian Carlos Abalos

    2003-01-01

    Full Text Available Numerosas instituciones han hecho accesibles sus datos a través de la infraestructura de comunicaciones que ofrece la internet, a través de la World Wide Web. Su amplia versatilidad permite trabajar con ficheros de texto, sonido, imágenes fijas y/o en movimiento, así como la capacidad de acceder desde ella a todos los otros servicios de internet. Bajo este esquema tecnológico surgieron los distintos recursos electrónicos de información. Para la preparación de un informe en los ámbitos académicos y científicos, cada día es más necesario citar y referirse a documentos e información obtenida a través de medios electrónicos. La utilización de estos recursos hace necesario contar con un sistema que determine un criterio adecuado para citarlos. En este artículo, se presenta una síntesis del estilo sugerido por la American Psychological Association para citar documentos electrónicos consultados a través de la internet.

  19. Study of Super-toughening Modification of PA 6/POE/SWR-3A%PA6/POE/SWR-3A超韧共混改性的研究

    Institute of Scientific and Technical Information of China (English)

    陆波; 徐晓强

    2005-01-01

    采用SWR-3A(POE-g-MAH)作为增容剂,研究了POE对PA6/POE/SWR-3A共混物的力学性能、耐热性和流变性能的影响.结果表明:在12.5份增容剂SWR-3A存在的条件下,随着POE 8150用量增大,共混物的缺口冲击强度不断增大,而拉伸强度、维卡耐热温度、表观粘度降低.当POE 8150用量超过12.5份时,共混物达到超韧.在PA6/POE/SWR-3A共混体系中,SWR-3A具有增容和增韧的双重作用.

  20. 46 CFR 5.501 - General.

    Science.gov (United States)

    2010-10-01

    ... mariner's credential or endorsement is a formal adjudication under the Administrative Procedure Act (APA... in accordance with applicable requirements in the APA, the rules in this part, and the rules...

  1. 77 FR 29696 - James Edgar Lundeen, Sr., M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2012-05-18

    .... \\2\\ In accordance with the Administrative Procedure Act (APA), an agency ``may take official notice...). In accordance with the APA and DEA's regulations, Respondent is ``entitled on timely request to...

  2. 77 FR 35054 - Donald Brooks Reece II, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2012-06-12

    .... \\2\\ In accordance with the Administrative Procedure Act (APA), an agency ``may take official notice...). In accordance with the APA and DEA's regulations, Respondent is ``entitled on timely request to...

  3. Gclust Server: 87487 [Gclust Server

    Lifescience Database Archive (English)

    Full Text Available NE RICH SECRETED PROTEIN APA (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein MPT32) (Antigen MPT-32) (...ECRETED PROTEIN APA (FIBRONECTIN ATTACHMENT PROTEIN) (Immunogenic protein MPT32) (Antigen MPT-32) (45-kDa gl

  4. What Is Psychiatry?

    Medline Plus

    Full Text Available ... APA Foundation APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Sign In Join General Residents and ... Learning Center APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Terms of Use Copyright Contact © 2017 ...

  5. 2010 Annual Report of the American Psychological Association

    Science.gov (United States)

    American Psychologist, 2011

    2011-01-01

    This report presents the 2010 annual report of the American Psychological Association (APA). It provides the highlights of the association's and individual directorate's activities to APA members. APA continued its efforts to advance psychological practice and ensure the public's access to high-quality psychological services, apply psychological…

  6. 49 CFR 173.56 - New explosives-definition and procedures for classification and approval.

    Science.gov (United States)

    2010-10-01

    ... requirements in APA Standard 87-1 (IBR, see § 171.7 of this subchapter); (2) A thermal stability test is... the Associate Administrator following the applicable requirements in APA Standard 87-1, and is... device for which approval is requested conforms to APA Standard 87-1 and that the descriptions...

  7. 78 FR 14166 - Clarification of Flight, Duty, and Rest Requirements

    Science.gov (United States)

    2013-03-05

    ... Standards Service, Federal Aviation Administration; email dale.e.roberts@faa.gov . For legal questions... a flightcrew member's FDP. iv. Physiological Night's Rest Allied Pilots Association (APA) asked... APA asked whether a layover facility could be a suitable accommodation. APA also asked whether a...

  8. 78 FR 60766 - Clarification on Fireworks Policy Regarding Approvals or Certifications for Specialty Fireworks...

    Science.gov (United States)

    2013-10-02

    ... requirements in the APA Standard 87-1, and pass a thermal stability test. Instead of applying to PHMSA, the manufacturer may apply in writing to an FCA with the information required in the APA Standard 87-1. After....64 or 173.65, the APA Standard 87-1 and the requirements below. \\2\\ An example of a...

  9. 78 FR 42457 - Hazardous Materials: Revision to Fireworks Regulations (RRR)

    Science.gov (United States)

    2013-07-16

    ... consumer fireworks comply with APA Standard 87-1 and are safe for transportation in commerce. To provide... firework prior to initial shipment to determine whether the device meets the requirements of APA Standard... are adequate to certify compliance with APA Standard 87-1 and whether the FCA certification...

  10. 77 FR 429 - Clarification and Further Guidance on the Fireworks Approvals Policy

    Science.gov (United States)

    2012-01-05

    ... specified in 49 CFR 173.56(j) and the American Pyrotechnic Association (APA) Standard 87-1. PHMSA... device for which the approval is requested conforms to the APA Standard 87-1, and the descriptions and... requested conforms to the APA Standard 87-1, and the descriptions and technical information contained in...

  11. 78 FR 69292 - TWIC Not Evidence of Resident Alien Status

    Science.gov (United States)

    2013-11-19

    ... K. Energy Effects L. Technical Standards M. Environment I. Abbreviations APA Administrative... recordkeeping reference in Sec. 141.35(d). III. Regulatory History The Administrative Procedure Act (APA....C. 553. The APA, however, excludes certain types of regulations and permits exceptions for...

  12. 76 FR 16852 - Hours of Service (HOS) of Drivers; Assessing the Safety Impact of the Exemption From the 14-Hour...

    Science.gov (United States)

    2011-03-25

    ... Pyrotechnics Association (APA) an exemption from the current HOS prohibition against driving a commercial motor...: Thomas Yager, FMCSA Driver and Carrier Operations Division; Office of Bus and Truck Standards and... 381.300(b)). APA's Independence Day Operations and the Exemption from 49 CFR 395.3(a)(2) APA is...

  13. 76 FR 5272 - Removal of Limitation of Approval of Prevention of Significant Deterioration Provisions...

    Science.gov (United States)

    2011-01-31

    ... Administrative Procedure Act (APA). DATES: This action is effective January 31, 2011. ADDRESSES: EPA has...'' exemption in section 553(b)(3)(B) of the APA. That provision authorizes agencies, upon finding ``good cause... CFR 52.53 that no longer serves any purpose. EPA also finds that there is good cause under APA...

  14. 75 FR 16668 - Race to the Top Fund

    Science.gov (United States)

    2010-04-02

    ... competition. Waiver of Rulemaking and Delayed Effective Date: Under the Administrative Procedure Act (APA) (5... rule. However, we are waiving the notice-and-comment rulemaking requirements under the APA. Section 553(b) of the APA provides that an agency is not required to conduct notice-and-comment rulemaking...

  15. 76 FR 5274 - Removal of Limitation of Approval of Prevention of Significant Deterioration Provisions...

    Science.gov (United States)

    2011-01-31

    ... requirements under the Administrative Procedure Act (APA). DATES: This action is effective January 31, 2011... falls under the ``good cause'' exemption in section 553(b)(3)(B) of the APA. That provision authorizes... good cause under APA section 553(d)(3) for this action to become effective on the date of...

  16. 77 FR 30241 - Representation Procedures and Rulemaking Authority

    Science.gov (United States)

    2012-05-22

    ... its rules according to the informal rulemaking procedures in the Administrative Procedure Act (APA), 5... amendment does not trigger the stricter requirements in sections 556 and 557 of the APA, this hearing will comply with those informal rulemaking procedures under the APA. See, e.g. United States v....

  17. 78 FR 49555 - Special Opportunities Fund, Inc.; Notice of Application

    Science.gov (United States)

    2013-08-14

    ... Section 554(e) of the Administrative Procedure Act of 1946 (``APA'') concerning a proxy voting procedure... order under Section 554(e) of the APA declaring that applicant's proxy voting procedure does not satisfy... declaratory order pursuant to Section 554(e) of the APA stating that the Voting Procedure ``does not cause...

  18. The Community College Presidency: An Asian Pacific American Perspective.

    Science.gov (United States)

    Fujimoto, M. Jack

    1996-01-01

    Analyzes the status of Asian Pacific Americans (APAs) in higher education compared to their representation in chief executive positions, describing a glass ceiling effect and common stereotypes regarding APAs. Reviews characteristics of chief executive officers in California community colleges. Provides strategies for increasing APA representation…

  19. Education Concerns of Asian and Pacific Americans. 1978 Conference Report.

    Science.gov (United States)

    Takei, Barbara

    Five national issues considered to be the most important to Asian and Pacific Americans' (APA) education priorities are discussed in this report. These include the need to: (1) increase Federal assistance and improve access for APAs; (2) gather more data and research on APA education needs; (3) promote more Asian and Pacific American participation…

  20. 76 FR 59085 - Appeals of Post Office Closings

    Science.gov (United States)

    2011-09-23

    ... Administrative Procedure Act, Public Law 79-404, 60 Stat. 237, 1946 (APA), `` `adjudication' means agency process... adjudications under the APA (5 U.S.C. 554) because, pursuant to section 404(d)(5)(C), the provisions of 5 U.S.C... covered by the APA at all, generally do not involve a hearing, and are subject to the specific...

  1. 75 FR 39633 - Extension of Deadline for Action on Section 126 Petition From New Jersey

    Science.gov (United States)

    2010-07-12

    .... Rule B. Notice-and-Comment Under the Administrative Procedures Act (APA) C. Effective Date Under the APA III. Statutory and Executive Order Reviews A. Executive Order 12866: Regulatory Planning and... is January 12, 2011. B. Notice-and-Comment Under the Administrative Procedures Act (APA)...

  2. 76 FR 80226 - Technical Amendments

    Science.gov (United States)

    2011-12-23

    ... Administrative Procedure Act (APA) requires a rulemaking to be published as a notice of proposed rulemaking with... regulations and conform them to current agency practice. Additionally, the APA requires that a final rule must... under the APA. 5 U.S.C. 553(d)(3). Again the technical change conforms the rule to current...

  3. 77 FR 213 - United States Savings Bonds, Series EE and I

    Science.gov (United States)

    2012-01-04

    ... Order 12866. Administrative Procedure Act (APA). Because this rule relates to United States securities... exception to the APA, 5 U.S.C. 553(a)(2). As a result, the notice, public comment, and delayed effective date provisions of the APA are inapplicable to this rule. Regulatory Flexibility Act. The provisions...

  4. 75 FR 49820 - Delegation of Authority to the Director of Its Division of Enforcement

    Science.gov (United States)

    2010-08-16

    ... the Administrative Procedure Act (``APA'') (5 U.S.C. 553(b)(3)(A)), that this amendment relates solely..., the provisions of the APA regarding notice of the proposed rulemaking, opportunities for public..., which apply only when notice and comment are required by the APA or other law, 5 U.S.C. 603, are...

  5. 77 FR 19079 - Removal of Regulations on Black Lung Benefits

    Science.gov (United States)

    2012-03-30

    ... Black Lung Part B program. Regulatory Procedures We follow the Administrative Procedure Act (APA) rulemaking procedures specified in 5 U.S.C. 553 when we develop regulations. Generally, the APA requires that... APA provides exceptions to its notice and public comment procedures when an agency finds good...

  6. Ensuring the Availability and Quality of School Psychology Doctoral Internships

    Science.gov (United States)

    Harris, Abigail M.

    2015-01-01

    Currently, only a small percentage of internships accredited by the American Psychological Association (APA) are filled by school psychology interns and only a few of the available APA internship positions are in schools. Program data submitted online to APA indicate that many interns are in sites that meet the guidelines adopted by the Council of…

  7. Recurrent Pregnancy Loss

    Directory of Open Access Journals (Sweden)

    Véronique Piroux

    1997-01-01

    Full Text Available Antiphospholipid antibodies (APA are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.

  8. Variation of Alkaline Phosphatase Activity in Sediments of Shrimp Culture Ponds and Its Relationship with the Contents of C, N and P

    Institute of Scientific and Technical Information of China (English)

    SU Yuepeng; MA Shen; DONG Shuanglin

    2005-01-01

    Nine enclosures (5 m × 5 m) were built in a Fenneropenaeus chinensis culture pond of Rushan Gulf in April, 2001.The probiotics and BIO ENERGIZER solution were applied for disparate treatments. Variations of alkaline phosphatase activity (APA) and its relationship with the contents of C, N and P in sediments were studied. Results show that APA of sediments increases from 3.096 nmol g-1min-1 to 5.407 nmol g-1nin-1 in culture period; the bacteria biomass is not the only factor to determine APA; the contents of total P and total organic carbon have a significant positive correlation with APA, while that of total nitrogen has a negative correlation. In addition, the contents of inorganic P and organic P are not regular with APA. By comparison, TOC shows a more significant coherence with APA, meaning that organic pollution in sediments affects APA remarkably.

  9. Alternative Polyadenylation in Triple-Negative Breast Tumors Allows NRAS and c-JUN to Bypass PUMILIO Posttranscriptional Regulation.

    Science.gov (United States)

    Miles, Wayne O; Lembo, Antonio; Volorio, Angela; Brachtel, Elena; Tian, Bin; Sgroi, Dennis; Provero, Paolo; Dyson, Nicholas

    2016-12-15

    Alternative polyadenylation (APA) is a process that changes the posttranscriptional regulation and translation potential of mRNAs via addition or deletion of 3' untranslated region (3' UTR) sequences. To identify posttranscriptional-regulatory events affected by APA in breast tumors, tumor datasets were analyzed for recurrent APA events. Motif mapping of the changed 3' UTR regions found that APA-mediated removal of Pumilio regulatory elements (PRE) was unusually common. Breast tumor subtype-specific APA profiling identified triple-negative breast tumors as having the highest levels of APA. To determine the frequency of these events, an independent cohort of triple-negative breast tumors and normal breast tissue was analyzed for APA. APA-mediated shortening of NRAS and c-JUN was seen frequently, and this correlated with changes in the expression of downstream targets. mRNA stability and luciferase assays demonstrated APA-dependent alterations in RNA and protein levels of affected candidate genes. Examination of clinical parameters of these tumors found those with APA of NRAS and c-JUN to be smaller and less proliferative, but more invasive than non-APA tumors. RT-PCR profiling identified elevated levels of polyadenylation factor CSTF3 in tumors with APA. Overexpression of CSTF3 was common in triple-negative breast cancer cell lines, and elevated CSTF3 levels were sufficient to induce APA of NRAS and c-JUN. Our results support the hypothesis that PRE-containing mRNAs are disproportionately affected by APA, primarily due to high sequence similarity in the motifs utilized by polyadenylation machinery and the PUM complex. Cancer Res; 76(24); 7231-41. ©2016 AACR.

  10. Altered Pathway Analyzer: A gene expression dataset analysis tool for identification and prioritization of differentially regulated and network rewired pathways

    Science.gov (United States)

    Kaushik, Abhinav; Ali, Shakir; Gupta, Dinesh

    2017-01-01

    Gene connection rewiring is an essential feature of gene network dynamics. Apart from its normal functional role, it may also lead to dysregulated functional states by disturbing pathway homeostasis. Very few computational tools measure rewiring within gene co-expression and its corresponding regulatory networks in order to identify and prioritize altered pathways which may or may not be differentially regulated. We have developed Altered Pathway Analyzer (APA), a microarray dataset analysis tool for identification and prioritization of altered pathways, including those which are differentially regulated by TFs, by quantifying rewired sub-network topology. Moreover, APA also helps in re-prioritization of APA shortlisted altered pathways enriched with context-specific genes. We performed APA analysis of simulated datasets and p53 status NCI-60 cell line microarray data to demonstrate potential of APA for identification of several case-specific altered pathways. APA analysis reveals several altered pathways not detected by other tools evaluated by us. APA analysis of unrelated prostate cancer datasets identifies sample-specific as well as conserved altered biological processes, mainly associated with lipid metabolism, cellular differentiation and proliferation. APA is designed as a cross platform tool which may be transparently customized to perform pathway analysis in different gene expression datasets. APA is freely available at http://bioinfo.icgeb.res.in/APA. PMID:28084397

  11. 2015 Annual Report of the American Psychological Association.

    Science.gov (United States)

    2016-01-01

    Presents the 2015 Annual Report of the American Psychological Association. In his introduction, President Barry Anton describes how 2015 was among APA's most challenging. Although 2015 ushered in an era of greater transparency within the association and enhanced communications to members and the public, it also required painful self-reflection stemming from the revelations of an independent review by an outside law firm. The review examined the question of whether APA played any role related to the Bush administration's use of abusive interrogation techniques during the war on terror. Anton's introduction also discusses (1) the APA convention, (2) representing APA at a White House meeting with health care providers and insurance companies, (3) APA's effort to increase the number of APA-accredited internships, (4) international activities, and (5) the global summit on psychology and integrated care. (PsycINFO Database Record

  12. The effect of asymmetry of posture on anticipatory postural adjustments.

    Science.gov (United States)

    Aruin, Alexander S

    2006-06-19

    The study investigates the effect of body asymmetry on anticipatory postural adjustments (APAs). Subjects performed a task involving a standard load release induced by a shoulder abduction movement while standing symmetrically or in an asymmetrical stance with either their right or left leg in 45 degrees of external rotation. EMG activities of trunk and leg muscles were recorded during the postural perturbation and were quantified within the time intervals typical of APAs. Anticipatory postural adjustments were observed in all experimental conditions. It was found that asymmetrical body positioning was associated with significant asymmetrical patterns of APAs seen in the right and left distal muscles. These APA asymmetries were dependant upon the side in which the body asymmetry was induced: reduced APAs were observed in the leg muscles on the side of leg rotation, while increased APAs were seen in the muscles on the contralateral side. These findings stress the important role that body asymmetries play in the control of upright posture.

  13. Adapted physical activity as an occupation, study program and academic discipline

    Directory of Open Access Journals (Sweden)

    Martin Kudláček

    2011-03-01

    Full Text Available Adapted Physical Activity (APA is the area focused on providing services to persons with special needs (e. g. disabilities and the academic discipline, which supports acceptance of individual differences and promotes provision of services and integration of persons with disabilities. Adapted Physical Activity includes among others physical education, sport, recreation and rehabilitation of persons with disabilities. The aim of this presentation is to describe basic historical and conceptual position of APA in kinanthropology in Europe, world and the Czech Republic. The article serves as an introduction to the special issue of this journal about APA and outcomes of project projektu EUSAPA (European Standards in Physical Activities. The project EUSAPA aimed to define professional standards in three areas of APA: (a Adapted physical education; (b APA in rehabilitation and (c APA in sports.

  14. 77 FR 36170 - TSCA Inventory Update Reporting Modifications; Chemical Data Reporting; 2012 Submission Period...

    Science.gov (United States)

    2012-06-18

    ... section 8(a), 15 U.S.C. 2607(a). Under section 553(b)(3)(B) of the Administrative Procedure Act (APA), 5 U... reports to EPA. Similarly, under APA section 553(d), 5 U.S.C. 553(d), the Agency may make a rule... comment rulemaking requirements under the APA, 5 U.S.C. 553, or any other statute. This rule is...

  15. Association of KCNJ5 gene missense mutations with aldosterone-producing adenoma and primary hyperaldosteronism

    Institute of Scientific and Technical Information of China (English)

    邵丹

    2013-01-01

    Objective To detect the KCNJ5 gene variations in aldosterone-producing adenoma (APA) with primary hyperaldosteronism (PA) ,and to investigate the association of the KCNJ5 gene missense mutations with APA and PA.Methods A total of 46 APA tumors and their clinical characteristics were collected from Hypertension Center of the People’s Hospital of Xinjiang Uygur Autonomous Region,and all the tumors were confirmed by pathology.

  16. Cross-Sectional Temperature Field of a Solar Collector's Absorber: Development of the Model / Saules Kolektora Absorbera Šķērsgriezuma Temperatūras Lauks Apaļas Caurulītes Gadījumā - Fināla Modelis

    Science.gov (United States)

    Barkans, V.; Shipkovs, P.; Vanags, M.

    2013-04-01

    In the work, the temperature field model is developed for the absorber of a round-pipe collector. As distinguished from previous models when the temperature of liquid was assumed to be constant over the entire pipe crosssection, the results obtained clearly show the temperature variations in the absorber's cross-section. In the work, optimal values are found in the work for geometrical parameters of the collector (i.e. the plate thickness and the pipe diameter) that allow the highest possible temperature of liquid to be achieved. Darbā iegūts temperatūras lauks saules kolektora absorbera šķērsgriezumam, uzskatot, ka siltumplūsmas process ir stacionārs. Rezultāti labi parāda temperatūras izmaiņu absorbera šķēsgriezumā. Šķidruma temperatūras atkarība no dažādiem ģeometriskajiem parametriem liecina, ka tiem eksistē optimālas vērtības, kuras nav jēgas palielināt, jo tas neatstāj ietekmi uz šķidruma temperatūru. Apstākļos, kuros saules radiācija ir liela un konstanta ilgu laika periodu, kolektora absorbers būtu jātaisa ar mazu b vērtību (attālumu no plates centra līdz caurulītes centram), lielu caurulītes diametru (līdz 14 mm) un lielu plates biezumu (līdz 1,2 mm). Apstākļos, kuros dominē mākoņainība, labāk konstruēt saules kolektoru ar lielāku b vērtību, mazu caurulītes diametru (no 6 līdz 8 mm) un mazu plates biezumu (0,5 mm).

  17. Viton(R)氟弹性体系列专题讲座(十)过氧化物硫化的APA型氟弹性体的耐燃油老化性能%Lecture of Viton(R) fluoroelastomer X:Long term fuel aging of peroxy cured"APA"fluoroelastomers

    Institute of Scientific and Technical Information of China (English)

    肖风亮

    2007-01-01

    该文主要介绍APA型氟弹性体与传统过氧化物硫化型氟弹性体的长期耐燃油性能比较.选取了标准的含六氟丙烯(HFP)的氟弹性体GF、GF-S、GBL、GBL-S以及含全氟甲基乙烯基醚(PMVE)低温改进型的氟弹性体GLT、GLT-S、GBLT-S、GFLT、GFLT-S进行了5 000 h的老化试验,老化介质是60℃的CM-15A燃油.在5 000 h的测试过程中,周期性地测量拉伸强度和体积溶胀的变化数据,此外还进行了燃油渗透测试和在酸性汽油中的性能变化测试,结果发现,APA型具有更佳的耐压缩永久变形性能和良好的耐燃油渗透性能.

  18. Intervenção em fisioterapia, baseada no conceito de Bobath, consegue influenciar os APA's da tibiotársica? Sujeitos com acidente vascular encefálico e com alteração do controlo postural do Complexo Lombo Pélvico Coxas

    OpenAIRE

    Farias, Sara Isabel Souto

    2016-01-01

    Introdução: Sujeitos pós-AVE apresentam frequentemente alterações do controlo postural do Complexo Lombo Pélvico Coxas (CLPC), que podem influenciar os ajustes posturais antecipatórios (APA’s). Este controlo postural é fundamental para assegurar a independência funcional e a participação social. Objetivo: Verificar, num grupo de participantes com AVE e com alterações do controlo postural do CLPC, se face à intervenção em fisioterapia, ocorreram alterações no comportamento e nos tempos de vari...

  19. "I Hate Video Games":从舆论到医学——美国精神病学会欲将游戏瘾列入精神病%'I hate video games' : from the Public Voice to Medicine-APA is Going to Add Vedio Game Addiction into the List of Mental Disorders

    Institute of Scientific and Technical Information of China (English)

    薛伟; 陈其庆

    2008-01-01

    @@ 对于绝大多数视频游戏玩家而言,游戏仅仅是游戏.它是一种以高科技手段来打发时间、尽情欢乐、在虚拟世界中一展身手的途径.然而,对于越来越多的超级游戏迷而言,则要严重得多--已经到了难以将现实和游戏分开的程度.

  20. Utilização de tecnicas de sensoriamento remoto e sistemas de informações geograficas para atualização e geração do mapa compilado de solos da area de proteçãoambiental - APA de Guaratuba (PR)

    OpenAIRE

    Schmidlin, Dirley

    1998-01-01

    Orientador: Helio Olympio da Rocha Dissertação (mestrado) - Universidade Federal do Parana, Setor de Ciencias Agrarias Resumo: O presente estudo objetivou a analise, atualização e compilação de mapas de solos, utilizando técnicas de sensoriamento remoto e sistemas de informações geogníficas. A Área de Proteçao Ambiental - AP A de Guaratuba, onde foi realizado o estudo, possuía sua área coberta com 9 mapas de solos de diversos autores, escalas e épocas. Empregando-se técnicas de processa...

  1. Anticipatory postural adjustments are unaffected by age and are not absent in patients with the freezing of gait phenomenon.

    Science.gov (United States)

    Plate, A; Klein, K; Pelykh, O; Singh, A; Bötzel, K

    2016-09-01

    In bipedal gait, the initiation of the first step is preceded by a complex sequence of movements which shift the centre of mass of the body towards the stance foot to allow for a step of the swing foot. These anticipatory postural adjustments (APAs) have been investigated in order to elucidate movement strategies in healthy and diseased persons. We studied the influence of several external parameters (age, type of step initiation) on APAs and investigated whether Parkinsonian patients may have different APAs. As a result, we found that externally elicited steps were preceded by faster and larger APAs than self-timed steps. Parkinsonian patients without the freezing of gait (FOG) phenomenon showed overall slightly reduced APAs but did not clearly differ from patients with FOG. Multiple APAs were seen in up to 25 % of the steps of the patients and in a much lower percentage of the steps of control subjects. The results indicate that APAs are significantly influenced by the timing of a step, i.e. are larger in externally elicited steps. The patients showed an overall preserved APA pattern but slowed movements and amplitude, indicating that increased bradykinesia due to progressive illness is a plausible explanation for these findings. The freezing phenomenon is not explained by a general absence or massive reduction in APA measures.

  2. 15 CFR 30.2 - General requirements for filing Electronic Export Information (EEI).

    Science.gov (United States)

    2010-01-01

    ... standards applicable to AES and AESDirect submissions.) (1) Submission of an electronic AES Participant Application (APA) for AES filing or submission of an online registration for filing through...

  3. American Psychiatric Association: Position Statement on Firearm Access, Acts of Violence and the Relationship to Mental Illness and Mental Health Services.

    Science.gov (United States)

    Pinals, Debra A; Appelbaum, Paul S; Bonnie, Richard; Fisher, Carl E; Gold, Liza H; Lee, Li-Wen

    2015-06-01

    The American Psychiatric Association, ("APA"), with more than 36,000 members at present, is the Nation's leading organization of physicians who specialize in psychiatry. APA provides for education and advocacy and develops policy through Position Statements. It promotes enhanced knowledge of particular topics relevant to psychiatric practice and patient care through Resource Documents. Since 1993, the APA has developed various positions and resource materials related to firearms and mental illness, incorporating evolving themes as new issues emerge. This paper reflects the APA's 2014 Position Statement on Firearm Access, Acts of Violence and the Relationship to Mental Illness and Mental Health Services.

  4. Low Complexity Adaptive Equalizers for Underwater Acoustic Communications

    Institute of Scientific and Technical Information of China (English)

    Masoumeh SOFLAEI; Paeiz AZMI

    2014-01-01

    Interference-signals-due-to-scattering-from-surface-and-reflecting-from-bottom-is-one-of-the-most-important-problems-of-reliable-communications-in-shallow-water-channels.-To-solve-this-problem,-one-of-the-best-suggested-ways-is-to-use-adaptive-equalizers.-Convergence-rate-and-misadjustment-error-in-adaptive-algorithms-play-important-roles-in-adaptive-equalizer-performance.-In-this-paper,-affine-projection-algorithm-(APA),-selective-regressor-APA(SR-APA),-family-of-selective-partial-update-(SPU)-algorithms,-family-of-set-membership-(SM)-algorithms-and-selective-partial-update-selective-regressor-APA-(SPU-SR-APA)-are-compared-with-conventional-algorithms-such-as-the-least-mean-square-(LMS)-in-underwater-acoustic-communications.-We-apply-experimental-data-from-the-Strait-of-Hormuz-for-demonstrating-the-efficiency-of-the-proposed-methods-over-shallow-water-channel.-We-observe-that-the-values-of-the-steady-state-mean-square-error-(MSE)-of-SR-APA,-SPU-APA,-SPU-normalized-least-mean-square-(SPU-NLMS),-SPU-SR-APA,-SM-APA-and-SM-NLMS-algorithms-decrease-in-comparison-with-the-LMS-algorithm.-Also-these-algorithms-have-better-convergence-rates-than-LMS-type-algorithm.

  5. Theory of affine projection algorithms for adaptive filtering

    CERN Document Server

    Ozeki, Kazuhiko

    2016-01-01

    This book focuses on theoretical aspects of the affine projection algorithm (APA) for adaptive filtering. The APA is a natural generalization of the classical, normalized least-mean-squares (NLMS) algorithm. The book first explains how the APA evolved from the NLMS algorithm, where an affine projection view is emphasized. By looking at those adaptation algorithms from such a geometrical point of view, we can find many of the important properties of the APA, e.g., the improvement of the convergence rate over the NLMS algorithm especially for correlated input signals. After the birth of the APA in the mid-1980s, similar algorithms were put forward by other researchers independently from different perspectives. This book shows that they are variants of the APA, forming a family of APAs. Then it surveys research on the convergence behavior of the APA, where statistical analyses play important roles. It also reviews developments of techniques to reduce the computational complexity of the APA, which are important f...

  6. Pain reported during prolonged standing is associated with reduced anticipatory postural adjustments of the deep abdominals.

    Science.gov (United States)

    Marshall, Paul W M; Romero, Rick; Brooks, Cristy

    2014-11-01

    Within the context of low back pain, the measurement of deep abdominal anticipatory postural adjustments (APAs) during rapid limb movement has received much interest. There is dispute about the association between APAs and back pain. Moreover, there is limited evidence examining compensatory postural adjustments (CPAs) in back pain. This study examined the relationship between APAs and CPAs with pain reported in the low back during 2 h of prolonged standing. Twenty-six participants with no history of severe back pain performed 2-h prolonged standing. APAs and CPAs of the deep abdominal muscles (transverse abdominis/internal obliques) were measured by surface electromyography during rapid shoulder flexion and extension. APAs and CPAs measured pre-standing revealed symmetrical anticipatory activity, but an asymmetry between the different sides of the abdominal wall for CPAs. APAs and CPAs measured pre-standing were not associated with pain reported during standing. For the whole group, APA amplitudes were reduced post-standing during shoulder flexion (p = 0.005). Pain reported during standing was associated with the changes in APA amplitudes post-standing (rs = 0.43, p = 0.002). These findings support previous research using hypertonic saline injections to induce back pain that showed reduced APA amplitudes, and extends findings to suggest pain does not effect compensatory postural adjustments.

  7. The Organization and Control of Intra-Limb Anticipatory Postural Adjustments and Their Role in Movement Performance.

    Science.gov (United States)

    Cavallari, Paolo; Bolzoni, Francesco; Bruttini, Carlo; Esposti, Roberto

    2016-01-01

    Anticipatory Postural Adjustments (APAs) are commonly described as unconscious muscular activities aimed to counterbalance the perturbation caused by the primary movement, so as to ensure the whole-body balance, as well as contributing to initiate the displacement of the body center of mass when starting gait or whole-body reaching movements. These activities usually create one or more fixation chains which spread over several muscles of different limbs, and may be thus called inter-limb APAs. However, it has been reported that APAs also precede voluntary movements involving tiny masses, like a flexion/extension of the wrist or even a brisk flexion of the index-finger. In particular, such movements are preceded by an intra-limb APA chain, that involves muscles acting on the proximal joints. Considering the small mass of the moving segments, it is unlikely that the ensuing perturbation could threaten the whole-body balance, so that it is interesting to enquire the physiological role of intra-limb APAs and their organization and control compared to inter-limb APAs. This review is focused on intra-limb APAs and highlights a strict correspondence in their behavior and temporal/spatial organization with respect to inter-limb APAs. Hence it is suggested that both are manifestations of the same phenomenon. Particular emphasis is given to intra-limb APAs preceding index-finger flexion, because their relatively simple biomechanics and the fact that muscular actions were limited to a single arm allowed peculiar investigations, leading to important conclusions. Indeed, such paradigm provided evidence that by granting a proper fixation of those body segments proximal to the moving one APAs are involved in refining movement precision, and also that APAs and prime mover activation are driven by a shared motor command.

  8. 75 FR 73951 - Amendments to General Regulations of the Food and Drug Administration

    Science.gov (United States)

    2010-11-30

    ... Procedure Act (APA) (5 U.S.C. 553). Comments that are frivolous, insubstantial, or outside the scope of the... APA. If we receive no significant adverse comment during the specified comment period, we intend to...: PART 1--GENERAL ENFORCEMENT REGULATIONS 0 The authority citation for part 1 is revised to read...

  9. 77 FR 64431 - Civil Monetary Penalty Inflation Adjustment Rule

    Science.gov (United States)

    2012-10-22

    ... final rule, without opportunity for public notice and comment. The Administrative Procedure Act (APA), 5... entities. Because the Board has determined that notice and comment are not required under the APA for this...: Adjusted Maximum maximum U.S. Code citation Civil monetary penalty description penalty amount...

  10. 77 FR 72247 - Rules of Practice and Procedure: Enterprise and Federal Home Loan Bank Housing Goals Related...

    Science.gov (United States)

    2012-12-05

    ... the record and in accordance with the Administrative Procedures Act (APA). This section also governs... specific rules of practice and procedure for hearings on the record and hearings in accordance with the APA.... The authority citation for part 1209 is revised to read as follows: Authority: 5 U.S.C. 554, 556,...

  11. 76 FR 37280 - Rural Health Care Support Mechanism

    Science.gov (United States)

    2011-06-27

    ... Administrative Procedure Act (APA) requires that agencies provide notice in the Federal Register and an.... In addition, section 553(d) of the APA requires a substantive rule to be published not less than 30... to read as follows: PART 54--UNIVERSAL SERVICE 0 1. The authority citation for part 54 continues...

  12. 76 FR 36979 - Golden Parachute and Indemnification Payments-Technical Correction

    Science.gov (United States)

    2011-06-24

    ... part 750 will take effect. 76 FR 30510 (May 26, 2011). The Administrative Procedure Act (APA), 5 U.S.C... as defined by Section 551 of the APA. 5 U.S.C. 551. NCUA does not believe this final rule is a.... The authority citation for part 750 continues to read as follows: Authority: 12 U.S.C. 1786(t). 0...

  13. 78 FR 18526 - Significant New Use Rules on Certain Chemical Substances; Technical Amendment

    Science.gov (United States)

    2013-03-27

    ... Procedure Act (APA) (5 U.S.C. 553(b)(3)(B)) provides that, when an Agency for good cause finds that notice... this technical amendment is not subject to notice and comment requirements under the APA or any other... part 721 is corrected as follows: PART 721-- 0 1. The authority citation for part 721 continues to...

  14. 77 FR 60897 - Safety Zone: America's Cup World Series Finish-Line, San Francisco, CA

    Science.gov (United States)

    2012-10-05

    ... INFORMATION: Table of Acronyms APA Administrative Procedure Act DHS Department of Homeland Security FR Federal... section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an... authority citation for part 165 continues to read as follows: Authority: 33 U.S.C. 1231; 46 U.S.C....

  15. 75 FR 81377 - Prohibited Service at Savings and Loan Holding Companies; Reinstitution of Expiration Date of...

    Science.gov (United States)

    2010-12-28

    ... public interest under section 552(b)(B) of the Administrative Procedure Act (APA); there is good cause for making the extension effective immediately under section 553(d) of the APA; and the delayed...: PART 585--PROHIBITED SERVICE AT SAVINGS AND LOAN HOLDING COMPANIES 0 1. The authority citation for...

  16. 75 FR 73984 - Amendments to General Regulations of the Food and Drug Administration

    Science.gov (United States)

    2010-11-30

    ... (APA) (5 U.S.C. 553). The comment period for this companion proposed rule runs concurrently with the...-comment process in accordance with the APA. Comments that are frivolous, insubstantial, or outside the... ENFORCEMENT REGULATIONS 1. The authority citation for part 1 is revised to read as follows: Authority: 15...

  17. 78 FR 47210 - National Practitioner Data Bank and Privacy Act; Exempt Records System; Technical Correction

    Science.gov (United States)

    2013-08-05

    ... Procedure Act (APA) (5 U.S.C. 553(b)). However, this notice and comment procedure can be waived if the... the notice. Section 553(d) of the APA ordinarily requires a 30-day delay in effective date of final...--PRIVACY ACT REGULATIONS 0 1. The authority citation for part 5b continues to read as follows: Authority:...

  18. Corporate Funding and Conflicts of Interest: A Primer for Psychologists

    Science.gov (United States)

    Pachter, Wendy S.; Fox, Ronald E.; Zimbardo, Philip; Antonuccio, David O.

    2007-01-01

    A presidential task force on external funding was established by the American Psychological Association (APA) in 2003 to review APA policies, procedures, and practices regarding the acceptance of funding and support from private corporations for educational and training programs; continuing education offerings; research projects; publications;…

  19. Courseware Development with Animated Pedagogical Agents in Learning System to Improve Learning Motivation

    Science.gov (United States)

    Chin, Kai-Yi; Hong, Zeng-Wei; Huang, Yueh-Min; Shen, Wei-Wei; Lin, Jim-Min

    2016-01-01

    The addition of animated pedagogical agents (APAs) in computer-assisted learning (CAL) systems could successfully enhance students' learning motivation and engagement in learning activities. Conventionally, the APA incorporated multimedia materials are constructed through the cooperation of teachers and software programmers. However, the thinking…

  20. Aminopeptidase A is a functional target in angiogenic blood vessels.

    NARCIS (Netherlands)

    Marchio, S.; Lahdenranta, J.; Schlingemann, R.O.; Valdembri, D.; Wesseling, P.; Arap, M.A.; Hajitou, A.; Ozawa, M.G.; Trepel, M.; Giordano, R.J.; Nanus, D.M.; Dijkman, H.B.P.M.; Oosterwijk, E.; Sidman, R.L.; Cooper, M.D.; Bussolino, F.; Pasqualini, R.; Arap, W.

    2004-01-01

    We show that a membrane-associated protease, aminopeptidase A (APA), is upregulated and enzymatically active in blood vessels of human tumors. To gain mechanistic insight, we evaluated angiogenesis in APA null mice. We found that, although these mice develop normally, they fail to mount the expected

  1. Animated Pedagogical Agents Effects on Enhancing Student Motivation and Learning in a Science Inquiry Learning Environment

    Science.gov (United States)

    van der Meij, Hans; van der Meij, Jan; Harmsen, Ruth

    2015-01-01

    This study focuses on the design and testing of a motivational animated pedagogical agent (APA) in an inquiry learning environment on kinematics. The aim of including the APA was to enhance students' perceptions of task relevance and self-efficacy. Given the under-representation of girls in science classrooms, special attention was given to…

  2. Animated pedagogical agents effects on enhancing student motivation and learning in a science inquiry learning environment

    NARCIS (Netherlands)

    Meij, van der H.; Meij, van der J.; Harmsen, Ruth

    2015-01-01

    This study focuses on the design and testing of a motivational animated pedagogical agent (APA) in an inquiry learning environment on kinematics. The aim of including the APA was to enhance students’ perceptions of task relevance and self-efficacy. Given the under-representation of girls in science

  3. Animated pedagogical agents effects on enhancing student motivation and learning in a science inquiry learning environment

    NARCIS (Netherlands)

    van der Meij, Hans; van der Meij, Jan; Harmsen, Ruth

    2015-01-01

    This study focuses on the design and testing of a motivational animated pedagogical agent (APA) in an inquiry learning environment on kinematics. The aim of including the APA was to enhance students’ perceptions of task relevance and selfefficacy. Given the under-representation of girls in science c

  4. 49 CFR 171.7 - Reference material.

    Science.gov (United States)

    2010-10-01

    .../publications.com; AAR Manual of Standards and Recommended Practices, Section C—Part III, Specifications for... Edition, March 1996 172.102. American Pyrotechnics Association (APA), P.O. Box 30438, Bethesda, MD 20824, (301) 907-8181, www.americanpyro.com: APA Standard 87-1, Standard for Construction and Approval...

  5. Knee trembling during freezing of gait represents multiple anticipatory postural adjustments.

    Science.gov (United States)

    Jacobs, Jesse V; Nutt, John G; Carlson-Kuhta, Patricia; Stephens, Marilee; Horak, Fay B

    2009-02-01

    Freezing of gait (FoG) is an episodic, brief inability to step that delays gait initiation or interrupts ongoing gait. FoG is often associated with an alternating shaking of the knees, clinically referred to as knee trembling or trembling in place. The pathophysiology of FoG and of the concomitant trembling knees is unknown; impaired postural adjustment in preparation for stepping is one hypothesis. We examined anticipatory postural adjustments (APAs) prior to protective steps induced by a forward loss of balance in 10 Parkinson's disease (PD) subjects with marked FoG and in 10 control subjects. The amplitude and timing of the APAs were determined from changes in the vertical ground-reaction forces recorded by a force plate under each foot and were confirmed by electromyographic recordings of bilateral medial gastrocnemius, tibialis anterior and tensor fascia latae muscles. Protective steps were accomplished with a single APA followed by a step for control subjects, whereas PD subjects frequently exhibited multiple, alternating APAs coexistent with the knee trembling commonly observed during FoG as well as delayed, inadequate or no stepping. These multiple APAs were not delayed in onset and were of similar or larger amplitude than the single APAs exhibited by the control subjects. These observations suggest that multiple APAs produce the knee trembling commonly associated with FoG and that FoG associated with a forward loss of balance is caused by an inability to couple a normal APA to the stepping motor pattern.

  6. 75 FR 9781 - Determination of Nonattainment and Reclassification of the Atlanta, Georgia, 8-Hour Ozone...

    Science.gov (United States)

    2010-03-04

    ... standard, was approved by EPA on March 6, 2008 (73 FR 12013). However, EPA inadvertently excluded Hall... the ``good cause'' exemption in section 553(b)(3)(B) of the Administrative Procedure Act (APA) which... there is good cause under APA section 553(d)(3) for this correction to become effective on the date...

  7. 77 FR 12205 - Mevinphos; Order Revoking Tolerances

    Science.gov (United States)

    2012-02-29

    .... (21 U.S.C. 346a(f)(1)(C)). Under the Administrative Procedures Act (APA), orders are expressly..., if applicable. C. Regulatory Flexibility Act Since this order is not a rule under the APA (5 U.S.C... Transfer and Advancement Act This action does not involve any technical standards that would require...

  8. 78 FR 48048 - Student Assistance General Provisions

    Science.gov (United States)

    2013-08-07

    ... standard Web-based screens and prompts. DATES: These regulations are effective August 7, 2013. FOR FURTHER.... 553) (APA), the Department generally offers interested parties the opportunity to comment on proposed..., and the APA does not require notice and comment rulemaking here. See, Bachow Communications Inc....

  9. 76 FR 79529 - Community Reinvestment Act Regulations

    Science.gov (United States)

    2011-12-22

    ... of the Joint Final Rule The agencies' CRA regulations establish CRA performance standards for small... the Administrative Procedure Act (APA), an agency may, for good cause, find (and incorporate the.... Under 5 U.S.C. 553(d)(3) of the APA, the required publication or service of a substantive rule shall...

  10. 24 CFR 200.944 - Supplementary specific requirements under the HUD building product standards and certification...

    Science.gov (United States)

    2010-04-01

    ... excluding any floor finishes. Copies of the APA Standard may be obtained from the American Plywood... accordance with procedures set forth in APA PRP-108 Performance Standards and Policies for Structural-Use... under the HUD building product standards and certification program for plywood and other...

  11. Self-Efficacy and Preparation of Scholarly Writing: Online Doctoral Coursework to Comprehensive Examination--a Mixed Method Study

    Science.gov (United States)

    Thomas, Sonya C.

    2013-01-01

    Writing is seldom explicitly taught, most specifically, in academic and scholarly writing. Therefore, this mixed methods correlational phenomenology research study explored the correlation between self-efficacy perception and course room preparation for the comprehensive examination, APA standards in the course room, APA standards evaluation for…

  12. Ethical Issues in the Use of Humans for Research.

    Science.gov (United States)

    Bashaw, W. L.

    The APA Ethical Principles, the University of Georgia policy, standard research texts, and research literature on specific methodologies, all in relation to ethical issues in human research, are discussed. The 10 APA principles state, in essence, that the investigator is responsible for what happens, that confidentiality and the protection of the…

  13. 75 FR 69889 - Extension of Deadline for Action on the Second Section 126 Petition From New Jersey

    Science.gov (United States)

    2010-11-16

    ... ambient air quality standards (NAAQS). Under the CAA, EPA is authorized to grant a time extension for... of Air Quality Planning and Standards, Geographic Strategies Group, Mail Code C539-04, Research... Administrative Procedures Act (APA) C. Effective Date Under the APA III. Statutory and Executive Order Reviews...

  14. 75 FR 80731 - Request for Exclusion of 120 Volt, 100 Watt R20 Short Incandescent Reflector Lamps

    Science.gov (United States)

    2010-12-23

    ... of energy conservation standards for incandescent reflector lamps a 120 volt, 100 watt R20 short lamp....gov . SUPPLEMENTARY INFORMATION: The Administrative Procedure Act (APA), 5 U.S.C. 551 et seq... APA, NEMA petitioned the Department of Energy for the issuance of a new rule, as set forth below....

  15. 75 FR 1712 - Approval and Promulgation of Air Quality Implementation Plans; Mississippi; Update to Materials...

    Science.gov (United States)

    2010-01-13

    ... measures and strategies used to attain and maintain the national ambient air quality standards (NAAQS). The...) of the Administrative Procedure Act (APA) which, upon finding ``good cause,'' authorizes agencies to... immediately (thereby avoiding the 30-day delayed effective date otherwise provided for in the APA)....

  16. 78 FR 68782 - Public Meeting on the Improve Tracking of Workplace Injuries and Illnesses Proposed Rule

    Science.gov (United States)

    2013-11-15

    ... or revoking occupational safety and health standards. Section 553 of the APA, which governs this... the Occupational Safety and Health Act of 1970 (OSH Act) are regulations, not standards. Therefore... (APA) (5 U.S.C. 553) rather than section 6 of the OSH Act (29 U.S.C. 655) and 29 CFR part 1911....

  17. 78 FR 49975 - Energy Conservation Program for Consumer Products: Landmark Legal Foundation; Petition for...

    Science.gov (United States)

    2013-08-16

    ... pertaining to microwave oven standards does not withstand scrutiny under the APA. It appears that DOE... Conservation Standards for Standby Mode and Off Mode for Microwave Ovens, Docket No. EERE-2011-BT-STD-0048, RIN... Administrative Procedure Act (APA), 5 U.S.C. 551 et seq., provides among other things that, `` ach agency...

  18. Making Psychology a Household Word

    Science.gov (United States)

    Levant, Ronald F.

    2006-01-01

    This article addresses Ronald F. Levant's four APA presidential initiatives for 2005. "Making Psychology a Household Word" was both the general theme for his presidency as well as an initiative in its own right. The other three initiatives were "Promoting Health Care for the Whole Person," "Enhancing Diversity Within APA," and "Developing an APA…

  19. Caught in the Middle: Understanding Asian Pacific American Perspectives on Affirmative Action through Blumer's Group Position Theory.

    Science.gov (United States)

    Inkelas, Karen Kurotsuchi

    2003-01-01

    This study examines Asian Pacific American undergraduates' views on affirmative action and their perspectives on U.S. race relations through Herbert Blumer's (1958) theory of group position. Results indicate that Asian Pacific American (APA) students may perceive other minority student applicants as inferior to APA applicants and feel threatened…

  20. 77 FR 1862 - Mailing of Tickets Under the Ticket to Work Program

    Science.gov (United States)

    2012-01-12

    .../disabilityresearch/ttw4/TTW_Rpt4_508_vol1r.pdf . \\8\\ Altshuler, Norma, et al., Provider Experiences Under the Revised... changes. Regulatory Procedures We follow the Administrative Procedure Act (APA) rulemaking procedures specified in 5 USC 553 when we develop regulations. Generally, the APA requires that an agency provide...

  1. Multicultural Training of Clinical and Counseling Psychology Doctoral Students: Ideals vs. Practice

    Science.gov (United States)

    White, Bryana F. C.

    2013-01-01

    The American Psychological Association (APA), which is the advocating body for the field of psychology, emphasizes the importance of multicultural competencies for researchers and clinicians (APA, 2003; 2010). Graduate students are the field's future professionals. The multicultural training of doctoral level clinical and counseling…

  2. Design and Validation of a Rubric to Assess the Use of American Psychological Association Style in Scientific Articles

    Science.gov (United States)

    Merma Molina, Gladys; Peña Alfaro, Hilda; Peña Alfaro González, Silvia Rosa

    2017-01-01

    In this study, the researchers will explore the process of designing and validating a rubric to evaluate the adaptation of scientific articles in the format of the "American Psychological Association" (APA). The rubric will evaluate certain aspects of the APA format that allow authors, editors, and evaluators to decide if the scientific…

  3. Reporting and Interpreting Effect Size in Quantitative Agricultural Education Research

    Science.gov (United States)

    Kotrlik, Joe W.; Williams, Heather A.; Jabor, M. Khata

    2011-01-01

    The Journal of Agricultural Education (JAE) requires authors to follow the guidelines stated in the Publication Manual of the American Psychological Association [APA] (2009) in preparing research manuscripts, and to utilize accepted research and statistical methods in conducting quantitative research studies. The APA recommends the reporting of…

  4. Probability as certainty : Dichotomous thinking and the misuse of p values

    NARCIS (Netherlands)

    Hoekstra, Rink; Finch, Sue; Kiers, Henk A.L.; Johnson, Addie

    2006-01-01

    Significance testing is widely used and often criticized. The Task Force on Statistical Inference of the American Psychological Association (TFSI, APA; Wilkinson & TFSI, 1999) addressed the use of significance testing and made recommendations that were incorporated in the fifth edition of the APA Pu

  5. An Introductory Summary of Various Effect Size Choices.

    Science.gov (United States)

    Cromwell, Susan

    This paper provides a tutorial summary of some of the many effect size choices so that members of the Southwest Educational Research Association would be better able to follow the recommendations of the American Psychological Association (APA) publication manual, the APA Task Force on Statistical Inference, and the publication requirements of some…

  6. Statistical Methods in Psychology Journals.

    Science.gov (United States)

    Willkinson, Leland

    1999-01-01

    Proposes guidelines for revising the American Psychological Association (APA) publication manual or other APA materials to clarify the application of statistics in research reports. The guidelines are intended to induce authors and editors to recognize the thoughtless application of statistical methods. Contains 54 references. (SLD)

  7. Interpreting and Reporting Effect Sizes in Research Investigations.

    Science.gov (United States)

    Tapia, Martha; Marsh, George E., II

    Since 1994, the American Psychological Association (APA) has advocated the inclusion of effect size indices in reporting research to elucidate the statistical significance of studies based on sample size. In 2001, the fifth edition of the APA "Publication Manual" stressed the importance of including an index of effect size to clarify…

  8. An Introduction to Confidence Intervals for Both Statistical Estimates and Effect Sizes.

    Science.gov (United States)

    Capraro, Mary Margaret

    This paper summarizes methods of estimating confidence intervals, including classical intervals and intervals for effect sizes. The recent American Psychological Association (APA) Task Force on Statistical Inference report suggested that confidence intervals should always be reported, and the fifth edition of the APA "Publication Manual"…

  9. Yeki Bood/Yeki Na Bood: Writing and Publishing as a Teacher Researcher.

    Science.gov (United States)

    Fecho, Bob

    2003-01-01

    Discusses considerations faced by practitioner researchers as they write for publication, particularly as they encounter the template of the Publication Manual of the American Psychological Association (APA). Argues that some APA conventions--such as beginning an article with theory rather than the story of the research--do not suite the purposes…

  10. Internship Training Directors' Perceptions of School Psychology Internship Applicants

    Science.gov (United States)

    Mahoney, Emery B.; Perfect, Michelle M.; Edwinson, Roxanne M.

    2015-01-01

    Since the mid-1990s, an imbalance between the number of available American Psychological Association (APA)-accredited internships and applicants has existed. In 2014, 14% of predoctoral psychology students who applied for internships accredited by the APA or members of the Association of Psychology Postdoctoral and Internship Centers (APPIC) did…

  11. Ethics as an Undergraduate Psychology Outcome: When, Where, and How to Teach It

    Science.gov (United States)

    Ruiz, Ana; Warchal, Judith

    2014-01-01

    The American Psychological Association (APA) recently approved a new set of "Guidelines for the undergraduate psychology major, version 2.0" (APA, 2013a) which addressed ethics specifically. Yet the teaching of ethics receives little attention in publications, national and international institutes, and conferences. Few guidelines for…

  12. Thermoplastic Composite Wind Turbine Blades: Kinetics and Processability

    NARCIS (Netherlands)

    Teuwen, J.J.E.

    2011-01-01

    In previous research, the potential of glass fibre reinforced anionic polyamide-6 (APA-6) composites for use in wind turbine blades was proven. Based on polymer properties, viscosity, processing time, costs and recyclability, APA-6 composites are considered the most suitable reactive thermoplastic m

  13. Tobacco industry influence on the definition of tobacco related disorders by the American Psychiatric Association

    OpenAIRE

    Neuman, M; Bitton, A.; Glantz, S

    2005-01-01

    Objective: The Diagnostic and statistical manual of mental disorders, third edition (DSM-III), published by the American Psychiatric Association (APA) in 1980, included the first official definitions by the APA of tobacco dependence and tobacco withdrawal. Tobacco industry efforts to influence the DSM-III were investigated.

  14. Enhanced Cognitive Rehabilitation to Treat Comorbid TBI and PTSD

    Science.gov (United States)

    2014-10-01

    These practice standards have been organized into a manualized treatment, Cognitive Symptom Management and Rehabilitation Therapy (CogSMART), which...Psychological Association ( APA ) to contribute to a symposium for the APA Convention in August 2014. The 2- hour symposium entitled “Active Recovery

  15. 76 FR 18365 - Fair Credit Reporting Act and Bank Secrecy Act Compliance

    Science.gov (United States)

    2011-04-04

    ... Procedure Act (APA), an agency may, for good cause, find (and incorporate the finding and a brief statement... and comment procedures prescribed by the APA are unnecessary because the final rule makes technical..., and the FFIEC Bank Secrecy Act/Anti-Money Laundering Examination Manual. (iii) Compliance. Failure...

  16. A Randomized Clinical Trial of Auricular Point Acupressure for Chronic Low Back Pain: A Feasibility Study

    Directory of Open Access Journals (Sweden)

    Chao Hsing Yeh

    2013-01-01

    Full Text Available Objectives. This prospective, randomized clinical trial (RCT was designed to investigate the feasibility and effects of a 4-week auricular point acupressure (APA for chronic low back pain (CLBP. Methods. Participants were randomized to either true APA (true acupoints with taped seeds on the designated ear points for CLBP or sham APA (sham acupoints with taped seeds but on different locations than those designated for CLBP. The duration of treatment was four weeks. Participants were assessed before treatment, weekly during treatment, and 1 month following treatment. Results. Participants in the true APA group who completed the 4-week APA treatment had a 70% reduction in worst pain intensity, a 75% reduction in overall pain intensity, and a 42% improvement in disability due to back pain from baseline assessment. The reductions of worst pain and overall pain intensity in the true APA group were statistically greater than participants in the sham group (P<0.01 at the completion of a 4-week APA and 1 month followup. Discussion. The preliminary findings of this feasibility study showed a reduction in pain intensity and improvement in physical function suggesting that APA may be a promising treatment for patients with CLBP.

  17. An Examination of Current Adapted Physical Activity Provision in Primary and Special Schools in Ireland

    Science.gov (United States)

    Crawford, Susan

    2011-01-01

    The Disability in Sport Taskforce report examining adapted physical activity (APA) in the Irish context (Department of Education and Science, 1999) found that teachers involved in primary mainstream and specialist settings expressed a grave lack of self-confidence, due to lack of training, in the delivery of APA programmes to children with special…

  18. Teen Dating Violence Prevention Program Assessment

    Science.gov (United States)

    Lucas, Quincy Arrianna Rose

    2013-01-01

    The American Psychological Association (APA) has identified the prevention of and intervention in relationship violence as a top priority (APA, n.d.). According to the Center for Disease Control and Prevention's 2012 Teen Dating Violence Fact Sheet, dating violence is a serious problem in the United States. In accordance with Foshee et al. (1998):…

  19. Adsorption of human immunoglobulin to implantable alginate-poly-L-lysine microcapsules : Effect of microcapsule composition

    NARCIS (Netherlands)

    Tam, Susan K.; de Haan, Bart J.; Faas, Marijke M.; Halle, Jean-Pierre; Yahia, L'Hocine; de Vos, Paul

    2009-01-01

    Alginate-poly-L-lysine-alginate (APA) microcapsules continue to be the most widely Studied device for the immuno-protection of transplanted therapeutic cells. Producing APA microcapsules having a reproducible and high level of biocompatibility requires an understanding of the mechanisms of the immun

  20. Joint effect of freshwater plume and coastal upwelling on phytoplankton growth off the Changjiang River

    Directory of Open Access Journals (Sweden)

    Y.-F. Tseng

    2013-06-01

    Full Text Available Changjiang River discharges vast amount of unbalanced nutrients (dissolved inorganic nitrogen (N and phosphorus (P with N / P > 80 in general into the East China Sea during summertime. To explore nutrient dynamics and P stress potential for phytoplankton, a cruise was conducted in the Changjiang plume during summer 2011. With 3-D observations of nutrients, chlorophyll a (Chl a, and bulk alkaline phosphatase activity (APA, we concluded that the Changjiang Diluted Water (CDW and coastal upwelling significantly influenced the horizontal and vertical heterogeneities of phytoplankton P-deficiency in the plume. Allochthonous APA was detected at nutrient-enriched freshwater end. Excessive N (~10 to 112 µM was obserevd throughout the entire plume surface. In the plume fringe where featured by stratification and excess N, diapycnal phosphate supply was blocked to stimulate APA for phytoplankton growth. We observed upwelling outcrops just attaching the turbidity front at seaward side, where Chl a peaked yet much less APA was detected. An external phosphate supply from subsurface, which stimulated phytoplankton growth but inhibited APA, was suggested and the supply was likely sourced from the Nearshore Kuroshio Branch Current. In such hydrographically complicated Changjiang plume, phosphate supply instead of its concentration was more important determining the expression of APA. Meanwhile, allochthounous APA may also alter the usefulness of APA as a P-stress indicator.

  1. Streptomyces as host for recombinant production of Mycobacterium tuberculosis proteins.

    Science.gov (United States)

    Vallin, Carlos; Ramos, Astrid; Pimienta, Elsa; Rodríguez, Caridad; Hernández, Tairí; Hernández, Ivones; Del Sol, Ricardo; Rosabal, Grisel; Van Mellaert, Lieve; Anné, Jozef

    2006-01-01

    The 45/47 kDa APA protein (Rv1860) of Mycobacterium tuberculosis was produced by Streptomyces lividans. The recombinant protein could be recovered from the culture medium of an S. lividans clone containing the apa gene under control of the promoter and signal sequence of the Streptomyces coelicolor agarase gene. The recombinant protein production was further scaled-up using fermentation conditions. The APA protein was subsequently purified from the culture supernatant by means of immunochromatography. About 80 mg of recombinant protein were obtained per liter of culture media. In vivo tests with the APA protein purified from S. lividans TK24/pRGAPA1 revealed that the recombinant protein was antigenic and could induce high titers of specific antibodies in the mouse biological model. Results obtained concerning heterologous production of APA, its immunogenic and antigenic capacity, demonstrated the potential of S. lividans as a valuable host for the production of recombinant proteins from M. tuberculosis.

  2. Alternative polyadenylation of tumor suppressor genes in small intestinal neuroendocrine tumors

    DEFF Research Database (Denmark)

    Rehfeld, Anders Aagaard; Plass, Mireya; Døssing, Kristina

    2014-01-01

    The tumorigenesis of small intestinal neuroendocrine tumors (SI-NETs) is poorly understood. Recent studies have associated alternative polyadenylation (APA) with proliferation, cell transformation, and cancer. Polyadenylation is the process in which the pre-messenger RNA is cleaved at a polyA site...... and a polyA tail is added. Genes with two or more polyA sites can undergo APA. This produces two or more distinct mRNA isoforms with different 3' untranslated regions. Additionally, APA can also produce mRNAs containing different 3'-terminal coding regions. Therefore, APA alters both the repertoire...... and the expression level of proteins. Here, we used high-throughput sequencing data to map polyA sites and characterize polyadenylation genome-wide in three SI-NETs and a reference sample. In the tumors, 16 genes showed significant changes of APA pattern, which lead to either the 3' truncation of mRNA coding regions...

  3. FBRM and PVM investigations of the double feed semi-batch crystallization of 6-aminopenicillanic acid

    Institute of Scientific and Technical Information of China (English)

    Min SU; Lin WANG; Hua SUN; Jingkang WANG

    2009-01-01

    6-Aminopenicillanic acid (6-APA) is a crucial pharmaceutical intermediate in the chemistry of semi-synthetic antibiotics. The focused beam reflectance measurement (FBRM) technology and particle vision measurement (PVM) technology were employed to the processes of online-monitoring of 6-APA crystallization behavior in a double-feeding semi-batch crystallizer. Experiments were carried out with four kinds of double-feeding policies and the results were compared with the traditional single-feeding. Records and analysis of FBRM indicated that the nucleation of double feeding policy was much higher than single policy, and chord length of 6-APA was almost determined and had little change after the nucleation peak. Ostwald ripening process had no significant effect on further growth of 6-APA crystal. PVM images showed that the crystal habit of 6-APA was continuously changed during the crystallization process. The development of (002) face in the final crystal for the five feeding policies were different.

  4. The use of ethnic minority populations in published psychological research, 1990-1999.

    Science.gov (United States)

    Imada, Toshie; Schiavo, R Steven

    2005-09-01

    For this study, the authors analyzed the contents of 16 psychology journals for the presence of empirical articles on African Americans, Latinos, Asians, and Native Americans during the period ranging from 1990 to 1999. In 6 APA journals, there was a low percentage (4.7%) of such articles. African Americans were the most studied ethnic group. Data collected for this study also indicated that minority research has been increasing more in non-APA journals than in APA journals. In both APA and non-APA journals, counseling-oriented journals had higher percentages of minority articles than did journals of other subdisciplines. Possible explanations, consequences, and suggestions for future research are discussed.

  5. Pelvic magnetic resonance imaging angioanatomy of the arterial blood supply to the penis in suspected prostate cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Thai, Cao Tan, E-mail: bstanhatinh@gmail.com [Department of Urology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France); IADI Laboratory, INSERM-U947, Brabois Hospital, University Hospital of Nancy, Tour Drouet, rue du Morvan, 54511 Vandoeuvre Lès Nancy Cedex (France); Karam, Ibrahim Michel [Clinical Epidemiology and Evaluation Department, University Hospital of Nancy (France); Department of Anatomy, Faculty of Medicine Nancy, 9 Avenue de la Foret de haye BP, 54505 Vandoeuvre Lès Nancy Cedex (France); Nguyen-Thi, Phi Linh [Clinical Epidemiology and Evaluation Department, University Hospital of Nancy (France); INSERM, CIC-EC CIE6, 92 Avenue du Maréchal de Lattre de Tassigny, 54000 Nancy (France); Lefèvre, Frédéric [Department of Radiology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France); Hubert, Jacques [Department of Urology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France); IADI Laboratory, INSERM-U947, Brabois Hospital, University Hospital of Nancy, Tour Drouet, rue du Morvan, 54511 Vandoeuvre Lès Nancy Cedex (France); Felblinger, Jacques [IADI Laboratory, INSERM-U947, Brabois Hospital, University Hospital of Nancy, Tour Drouet, rue du Morvan, 54511 Vandoeuvre Lès Nancy Cedex (France); Eschwège, Pascal [Department of Urology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France)

    2015-05-15

    Highlights: • Three patterns of penile arterial supply (according to the classification of Stéphane Droupy). • Our classification about accessory pudendal artery. • Origin of accessory pudendal artery. - Abstract: Purpose: To describe the internal pudendal artery (IPA) and accessory pudendal artery (APA) detected by magnetic resonance (MR) angiography to help surgeons to find and preserve them during radical prostatectomy (RP). Materials and methods: Constrast-enhanced MR 3.0 T angiography of the pelvis were performed in 111 male patients suspected diagnosis of prostate cancer (PCa), and describe the penile arterial blood supply. Results: There are three patterns of the arterial blood supply to the penis (IPA and/or APA) accounting for 51.4%, 46.8% and 1.8% of cases, respectively. About the accessory pudendal artery (APA): 54/111 (48.6%) patients had APA with five different branching patterns, they were type I (APA bilateral symmetry): 17 (31.5%); type II (APA bilateral asymmetry): 1 (1.9%); type III (APA unilateral lateral): 13 (24%); type IV (APA unilateral apical): 21 (38.9%); type V (APA unilateral mix): 2 (3.7%). APA origin were from inferior epigastric artery (IEA): 7 (9.5%); from inferior vesical artery (IVA): 32 (43.2%); from obturator artery (OA): 35 (47.3%). Conclusion: A precise angioanatomic evalutation of arteries destined to the penis by MR angiography pre-operation for male pelvic organs will help surgeons to preserve them and contributes to reduce the erectile dysfunction after these procedures.

  6. DHEA, DHEAS and PCOS.

    Science.gov (United States)

    Goodarzi, Mark O; Carmina, Enrico; Azziz, Ricardo

    2015-01-01

    Approximately 20-30% of PCOS women demonstrate excess adrenal precursor androgen (APA) production, primarily using DHEAS as a marker of APA in general and more specifically DHEA, synthesis. The role of APA excess in determining or causing PCOS is unclear, although observations in patients with inherited APA excess (e.g., patients with 21-hydroxylase deficient congenital classic or non-classic adrenal hyperplasia) demonstrate that APA excess can result in a PCOS-like phenotype. Inherited defects of the enzymes responsible for steroid biosynthesis, or defects in cortisol metabolism, account for only a very small fraction of women suffering from hyperandrogenism or APA excess. Rather, women with PCOS and APA excess appear to have a generalized exaggeration in adrenal steroidogenesis in response to ACTH stimulation, although they do not have an overt hypothalamic-pituitary-adrenal axis dysfunction. In general, extra-adrenal factors, including obesity, insulin and glucose levels, and ovarian secretions, play a limited role in the increased APA production observed in PCOS. Substantial heritabilities of APAs, particularly DHEAS, have been found in the general population and in women with PCOS; however, the handful of SNPs discovered to date account only for a small portion of the inheritance of these traits. Paradoxically, and as in men, elevated levels of DHEAS appear to be protective against cardiovascular risk in women, although the role of DHEAS in modulating this risk in women with PCOS remains unknown. In summary, the exact cause of APA excess in PCOS remains unclear, although it may reflect a generalized and inherited exaggeration in androgen biosynthesis of an inherited nature.

  7. Presence and patterns of alkaline phosphatase activity and phosphorus cycling in natural riparian zones under changing nutrient conditions

    Directory of Open Access Journals (Sweden)

    Peifang Wang

    2014-08-01

    Full Text Available Phosphorus (P is an important limiting nutrient in aquatic ecosystems and knowledge of P cycling is fundamental for reducing harmful algae blooms and other negative effects in water. Despite their importance, the characteristics of P cycling under changing nutrient conditions in shallow lakes were poorly investigated. In this study, in situ incubation experiments were conducted in a natural riparian zone in the main diversion channel used for water transfer into Lake Taihu (Wangyu River. Variations in microbial biomass, dissolved P fractions (organic and inorganic, and alkaline phosphatase activity (bulk APA and specific APA were determined after incubation with and without the addition of P and nitrogen (N (4 total water treatments: +P, +N, +NP, and control. Experiments were conducted during two seasons (late spring and early fall to account for natural differences in nutrient levels that may occur in situ. Our results demonstrated that low levels of DRP may not necessarily indicate P limitation. Phytoplankton exhibited “serial N limitation with P stress” in May, such that chlorophyll a (Chl a increased significantly with N addition, while the limiting nutrient shifted to P in October and phytoplankton biomass increased with P addition. Phytoplankton contributed greatly to APA production and was significantly influenced by P bioavailability, yet high levels of bulk APA were also not necessarily indicative of P limitation. In contrast to phytoplankton, bacteria were less P stressed. As a consequence of enhanced utilization of dissolved reactive P (DRP and dissolved organic P (DOP, +N treatment elevated APA significantly. By contrast, APA could be repressed to low values and phytoplankton converted a large portion of DRP to DOP with P addition. But this was not consistent with bacteria APA (bact-APA in the absence or presence of abundant phytoplankton biomass. The correlation between bulk APA and DRP was good at separate sites and discrepant

  8. Fabrication of Gold-Coated Ultra-Thin Anodic Porous Alumina Substrates for Augmented SERS

    Directory of Open Access Journals (Sweden)

    Chiara Toccafondi

    2016-05-01

    Full Text Available Anodic porous alumina (APA is a nanostructured material used as a template in several nanotechnological applications. We propose the use of APA in ultra-thin form (<100 nm for augmented surface-enhanced Raman scattering (SERS. Here, the effect of in-depth thinning of the APA nanostructures for possible maximization of SERS was addressed. Anodization was carried out on ultra-thin films of aluminum on glass and/or silicon, followed by pore-opening. Gold (Au was overcoated and micro‑Raman/SERS measurements were carried out on test target analytes. Finite integration technique simulations of the APA-Au substrate were used both for the experimental design and simulations. It was observed that, under optimized conditions of APA and Au thickness, the SERS enhancement is higher than on standard APA-Au substrates based on thin (~100 nm APA by up to a factor of ~20 for test molecules of mercaptobenzoic acid. The agreement between model and experimental results confirms the current understanding of SERS as being mainly due to the physical origin of plasmon resonances. The reported results represent one step towards micro-technological, integrated, disposable, high-sensitivity SERS chemical sensors and biosensors based on similar substrates.

  9. Adaptive Equalizer Using Selective Partial Update Algorithm and Selective Regressor Affine Projection Algorithm over Shallow Water Acoustic Channels

    Directory of Open Access Journals (Sweden)

    Masoumeh Soflaei

    2014-01-01

    Full Text Available One of the most important problems of reliable communications in shallow water channels is intersymbol interference (ISI which is due to scattering from surface and reflecting from bottom. Using adaptive equalizers in receiver is one of the best suggested ways for overcoming this problem. In this paper, we apply the family of selective regressor affine projection algorithms (SR-APA and the family of selective partial update APA (SPU-APA which have low computational complexity that is one of the important factors that influences adaptive equalizer performance. We apply experimental data from Strait of Hormuz for examining the efficiency of the proposed methods over shallow water channel. We observe that the values of the steady-state mean square error (MSE of SR-APA and SPU-APA decrease by 5.8 (dB and 5.5 (dB, respectively, in comparison with least mean square (LMS algorithm. Also the families of SPU-APA and SR-APA have better convergence speed than LMS type algorithm.

  10. Alaska Power Administration combined financial statements, schedules, and supplemental reports, September 30, 1997 and 1996 with independent auditors` report thereon

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The Alaska Power Administration (APA) will continue to encourage economic and industrial development in Alaska through implementing the sale of APA assets in a manner consistent with the authorizing legislation while balancing all the stakeholders` interests. Alaska Power Administration will provide their employees opportunities for successful career transitions and conduct an efficient transfer of assets and closeout of APA, while continuing to provide customers reliable, low-cost hydroelectric energy during the transition. The attached report presents the results of the independent certified public accounts` audit of the Alaska Power Administration`s (APA) combined power system statements of assets; Federal investment and liabilities; and the related combined statements of revenues, expenses and accumulated net revenues, and cash flows. The auditors` reports on APA`s internal control structure and compliance with laws and regulations disclosed no reportable conditions or instances of noncompliance. Based on the unqualified opinion of the independent public accounting firm of KPMG Peak Marwick LLP and review of their audit work, the authors believe the financial statements fairly present the financial condition and results of the operations of APA for the period under audit.

  11. [Effects of simulated nitrogen deposition on soil acid phosphomonoesterase activity and soil available phosphorus content in subtropical forests in Dinghushan Mountain].

    Science.gov (United States)

    Li, Yin; Zeng, Shu-cai; Huang, Wen-juan

    2011-03-01

    An in situ field experiment was conducted to study the effects of simulated nitrogen (N) deposition on soil acid phosphomonoesterase activity (APA) and soil available phosphorous (AP) content in Pinus massoniana forest (PF), coniferous and broad-leaved mixed forest (MF), and monsoon evergreen broad-leaved forest (MEBF) in Dinghushan Mountain. In PF and MF, three treatments were installed, i.e., CK (0 kg N x hm(-2) x a(-1)), low N (50 kg N x hm(-2) x a(-1)), and medium N (100 kg N x hm(-2) x a(-1)); in MEBF, four treatments were installed, i.e., CK, low N, medium N, and high N (150 kg N x hm(-2) x a(-1)). The soil APA and soil AP content decreased with soil depth. The soil APA was the highest in MEBF, while the AP content had no significant difference in the three forests. The effects of N addition on soil APA differed with forest types. In MEBF, the APA was the highest (19.52 micromol x g(-1) x h(-1)) in low N treatment; while in PF and MF, the APA was the highest (12.74 and 11.02 micromol x g(-1) x h(-1), respectively) in medium N treatment. In the three forests, soil AP content was the highest in low N treatment, but had no significant differences among the N treatments. There was a significant positive correlation between soil APA and soil AP content.

  12. The obstetric outcome following treatment in a cohort of patients with antiphospholipid antibody syndrome in a tertiary care center

    Directory of Open Access Journals (Sweden)

    V Dadhwal

    2011-01-01

    Full Text Available Background: Antiphospholipid antibody syndrome (APAS is regarded as the most frequently acquired risk factor for thrombophilia. The obstetric manifestations of APAS include early or late pregnancy losses and complications like preeclampsia and fetal growth restriction. Its timely diagnosis and treatment can improve maternal and neonatal outcome. Aims: To study the pregnancy outcome of patients with APAS treated with heparin and aspirin. Settings and Design: This was a retrospective study of pregnancy outcome in 42 consecutive women with APAS, treated with heparin and aspirin. Materials and Methods: The case records of 42 diagnosed cases of APAS with pregnancy, over a 3-year period, were studied. The pregnancy outcome in this group was compared before and after treatment with heparin and low-dose aspirin in terms of abortions, intrauterine deaths and live birth rate. The outcome of the present pregnancy in terms of fetal and maternal complications was analyzed. Results: The mean age and average parity of women with APAS were 30.1±4.1 years and 3.2±1.2, respectively. Among the treated patients of APAS, 13 (30.9% had preeclampsia and 9 (21.4% had intrauterine growth restriction (IUGR. There were 2 (4.7% intrauterine deaths, 4 (9.5% missed abortions and 3 (7.1% abruptio placentae. Women with APAS had a live birth rate of 4.6% before treatment and 85.7% in the index pregnancy after treatment. Conclusion: Treatment of pregnant women with APAS results in marked improvement in the live birth rate (4.6-85.7%. However, complications like preeclampsia and IUGR occur even after treatment, requiring strict monitoring and timely delivery.

  13. Alkaline phosphatase activity related to phosphorus stress of microphytoplankton in different trophic conditions

    Science.gov (United States)

    Ivančić, Ingrid; Pfannkuchen, Martin; Godrijan, Jelena; Djakovac, Tamara; Marić Pfannkuchen, Daniela; Korlević, Marino; Gašparović, Blaženka; Najdek, Mirjana

    2016-08-01

    The northern Adriatic (NA) is a favorable basin for studying the adaptive strategies of plankton to a variety of conditions along the steep gradients of environmental parameters over the year. Earlier studies identified phosphorus (P)-limitation as one of the key stresses within the NA that shape the biological response in terms of biodiversity and metabolic adjustments. A wide range of reports supports the notion that P-limitation is a globally important phenomenon in aquatic ecosystems. In this study P stress of marine microphytoplankton was determined at species level along a trophic gradient in the NA. In P-limitation all species with considerable contributions to the diatom community expressed alkaline phosphatase activity (APA), compared to only a few marginal dinoflagellate species. Nevertheless, APA expressing species did not always dominate the phytoplankton community, suggesting that APA is also an important strategy for species to survive and maintain active metabolism outside of their mass abundances. A symbiotic relationship could be supposed for diatoms that did not express APA themselves and probably benefited from APA expressed by attached bacteria. APA was not expressed by any microphytoplankton species during the autumn when P was not limiting, while most of the species did express APA during the P-limitation. This suggests that APA expression is regulated by orthophosphate availability. The methods employed in this study allowed the microscopic detection of APA for each microphytoplankton cell with simultaneous morphologic/taxonomic analysis. This approach uncovered a set of strategies to compete in P-limited conditions within the marine microphytoplankton community. This study confirms the role of P-limitation as a shaping factor in marine ecosystems.

  14. Army’s Audit Readiness at Risk Because of Unreliable Data in the Appropriation Status Report

    Science.gov (United States)

    2014-06-26

    reporting system or through an offline manual process in report preparation are classified as journal voucher adjustments.  Reporting timeframes...Column Absolute Value of Reported Differences (in thousands) OMA 2013 493 C $279,679 APA 2012 through 2014 014 B 10,000 APA 2012 through 2014 014 C...10,000 APA 2012 through 2014 014 D 10,000 MPA 2012 through 2014 009 B 28,548 MPA 2012 through 2014 009 C 13,593 MPA 2012 through 2014 009 D 1,361 MPA

  15. Defining adapted physical activity: international perspectives.

    Science.gov (United States)

    Hutzler, Yeshayahu; Sherrill, Claudine

    2007-01-01

    The purpose of this study was to describe international perspectives concerning terms, definitions, and meanings of adapted physical activity (APA) as (a) activities or service delivery, (b) a profession, and (c) an academic field of study. Gergen's social constructionism, our theory, guided analysis of multiple sources of data via qualitative methodology. Data sources were online surveys, APA literature, and expertise of researchers. Findings, with the identification of further considerations, were provided for each APA component to stimulate reflection and further inquiry among international professionals with diverse backgrounds.

  16. Implications of Antiphospholipid and Antineutrophilic Cytoplasmic Antibodies in the Context of Postinfectious Glomerulonephritis

    Science.gov (United States)

    Leifer, Daniel

    2017-01-01

    While antineutrophil cytoplasmic antibody (ANCA) positivity has been documented in some patients with postinfectious glomerulonephritis (PIGN) and is associated with more severe disease, antiphospholipid antibodies (APA) are not known to be a common occurrence. We describe a child with severe acute kidney injury who was noted to have prolonged positivity of both ANCA and APA; a renal biopsy showed noncrescentic immune complex mediated glomerulonephritis with subepithelial deposits compatible with PIGN. He recovered without maintenance immunosuppressive therapy and at last follow-up had normal renal function. We discuss the cooccurrence and implications of ANCA and APA in children with PIGN. PMID:28255306

  17. Expression of Angiotensin Ⅱ Receptors in Aldosterone-producing Adenoma of the Adrenal Gland and Their Clinical Significance

    Institute of Scientific and Technical Information of China (English)

    吴准; 倪栋; 闫永吉; 李俊; 王保军; 欧阳金枝; 张国玺; 马鑫; 李宏召; 张旭

    2010-01-01

    The expression of angiotensin Ⅱ type 1 receptor (AT1R) and angiotensin Ⅱ type 2 receptor (AT2R) in aldosterone-producing adenoma (APA) of the adrenal gland was detected, and their relationship with clinical indexes of APA was analyzed. The mRNA expression of AT1R and AT2R in 50 cases of APA and tissues adjacent to tumors and 12 cases of normal adrenal tissues was detected by using reverse transcriptase polymerase chain reaction (RT-PCR). The expression of AT1R and AT2R proteins in paraffin-embedded slices o...

  18. Acta Dermatovenerologica Alpina, Pannonica et Adriatica accepted for coverage in Thomson Reuters' Emerging Sources Citation Index (ESCI).

    Science.gov (United States)

    Poljak, Mario; Miljković, Jovan; Triglav, Tina

    2016-09-01

    Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) is the leading journal in dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 25 years to improve the journal's quality, global visibility, and international impact. After a 1-year trial period, Thomson Reuters recently informed the editorial office that they had accepted Acta Dermatovenerol APA for coverage in Thomson Reuters' new index in the Web of Science Core Collection called the Emerging Sources Citation Index (ESCI). The coverage of Acta Dermatovenerol APA begins with the journal content published online in 2016; that is, from volume 25 onwards.

  19. 76 FR 28173 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-05-16

    ..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  20. 77 FR 37799 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-06-25

    ..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  1. 78 FR 77597 - Safety Zone; Allied PRA-Solid Works, San Diego Bay; San Diego, CA

    Science.gov (United States)

    2013-12-24

    ... authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  2. 77 FR 42627 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-07-20

    ... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue SW... authority citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103,...

  3. 77 FR 65818 - Safety Zone; Bridge Demolition Project; Indiana Harbor Canal, East Chicago, IN

    Science.gov (United States)

    2012-10-31

    ... pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This... LIMITED ACCESS AREAS 0 1. The authority citation for Part 165 continues to read as follows: Authority:...

  4. 78 FR 17869 - Safety Zone; Desert Storm Shootout; Lake Havasu, Lake Havasu City, AZ

    Science.gov (United States)

    2013-03-25

    ... pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  5. 78 FR 11099 - Safety Zone Within the Lower Portion of Anchorage #9, Mantua Creek Anchorage; Paulsboro, NJ

    Science.gov (United States)

    2013-02-15

    ... opportunity to comment pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U... authority citation for part 165 continues to read as follows: Authority: 33 U.S.C 1231; 46 U.S.C....

  6. 77 FR 65623 - Security Zones; USCGC WILLIAM FLORES Commissioning Ceremony, Ybor Channel; Tampa, FL

    Science.gov (United States)

    2012-10-30

    ... Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior notice... AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues to read as...

  7. 75 FR 57384 - Rescission of Rules Pertaining to the Payment of Bounties for Information Leading to the Recovery...

    Science.gov (United States)

    2010-09-21

    ... Act (``APA'') generally requires an agency to publish notice of a proposed rulemaking in the Federal... authority citation for part 201 continues to read as follows: Authority: 15 U.S.C. 77s, 77sss, 78w, 78x,...

  8. 77 FR 42638 - Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA

    Science.gov (United States)

    2012-07-20

    ... Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without... authority citation for Part 165 continues to read as follows: Authority: 33 U.S.C. 1226, 1231; 46...

  9. 77 FR 42640 - Safety Zone; Can-Am Festival Fireworks, Black River Bay, Sackets Harbor, NY

    Science.gov (United States)

    2012-07-20

    ... Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior notice... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  10. 77 FR 42649 - Safety Zone: Sea World San Diego Fireworks, Mission Bay; San Diego, CA

    Science.gov (United States)

    2012-07-20

    ... authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  11. 75 FR 60305 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-09-30

    ... Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA-200), FAA... citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40106, 40113,...

  12. Citation Styles For Internet Resources : A Webliography

    Directory of Open Access Journals (Sweden)

    2004-12-01

    Full Text Available A Webliography collects resources about citation Styles For internet resources, it divided by the styles: Chicago University style, MLA style, APA style, ISO style, and some articles about internet resources citation.

  13. 77 FR 45925 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-08-02

    ..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40106, 40113,...

  14. 78 FR 13241 - Drawbridge Operation Regulation; Sabine River, Near Ruliff, LA

    Science.gov (United States)

    2013-02-27

    ... comment pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b... authority citation for part 117 continues to read as follows: Authority: 33 U.S.C. 499; 33 CFR...

  15. 77 FR 42644 - Safety Zone; Canal Fest of the Tonawandas, Erie Canal, Tonawanda, NY

    Science.gov (United States)

    2012-07-20

    ... Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior notice... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  16. 78 FR 19100 - Special Local Regulations; Charleston Race Week, Charleston Harbor; Charleston, SC

    Science.gov (United States)

    2013-03-29

    ...) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to.... The authority citation for part 100 continues to read as follows: Authority: 33 U.S.C. 1233. 0 2....

  17. 78 FR 36660 - Safety Zone; Mississippi River Mile 95.5-Mile 96.5; New Orleans, LA

    Science.gov (United States)

    2013-06-19

    ...) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to...--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues...

  18. 76 FR 61040 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-10-03

    ..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40106, 40113,...

  19. 78 FR 77592 - Safety Zone; Lower Mississippi River Mile 94.1-Mile 95.1; New Orleans, LA

    Science.gov (United States)

    2013-12-24

    ... pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This...--REGULATED NAVIGATION AREAS AND LIMITED ACESS AREAS 0 1. The authority citation for part 165 continues...

  20. 78 FR 4788 - Regulated Navigation Area; Reporting Requirements for Barges Loaded With Certain Dangerous...

    Science.gov (United States)

    2013-01-23

    ... under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  1. 78 FR 71493 - Special Local Regulation; Lake Havasu City Christmas Boat Parade of Lights; Colorado River; Lake...

    Science.gov (United States)

    2013-11-29

    ... authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... 1. The authority citation for Part 100 continues to read as follows: Authority: 33 U.S.C. 1233. 0...

  2. 75 FR 915 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-01-07

    ... Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  3. 77 FR 60899 - Safety Zone; Sea World San Diego Fireworks, Mission Bay; San Diego, CA

    Science.gov (United States)

    2012-10-05

    ... opportunity to comment pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U... authority citation for part 165 continues to read as follows: Authority: 33 U.S.C. 1226, 1231; 46...

  4. 78 FR 55219 - Safety Zone; Flying Machine Competition, Chicago, IL

    Science.gov (United States)

    2013-09-10

    ... opportunity to comment pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U... authority citation for part 165 continues to read as follows: Authority: 33 U.S.C. 1231; 46 U.S.C....

  5. 33 CFR 1.05-35 - Notice of proposed rulemaking (NPRM).

    Science.gov (United States)

    2010-07-01

    ... Administrative Procedure Act (APA), 5 U.S.C. 553, an NPRM is generally published in the Federal Register for... discussion of any comments received in response to prior notices, a citation of legal authority for the...

  6. 78 FR 21242 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-04-10

    ..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  7. 78 FR 11097 - Artificial Island Anchorage No. 2 Partial Closure, Delaware River; Salem, NJ

    Science.gov (United States)

    2013-02-15

    ... Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without... follows: PART 165--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation...

  8. 77 FR 42647 - Safety Zone: San Diego Symphony POPS Fireworks; San Diego, CA

    Science.gov (United States)

    2012-07-20

    ... authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... 1. The authority citation for part 165 continues to read as follows: Authority: 33 U.S.C. 1226,...

  9. 77 FR 75560 - Chlorantraniliprole; Pesticide Tolerances, Technical Correction

    Science.gov (United States)

    2012-12-21

    ... Administrative Procedure Act (APA) (5 U.S.C. 553(b)(3)(B)) provides that, when an agency for good cause finds... follows: PART 180-- 0 1. The authority citation for part 180 continues to read as follows: Authority: 21...

  10. 78 FR 14913 - Domestic Baggage Liability

    Science.gov (United States)

    2013-03-08

    ... Notices The Administrative Procedure Act (APA) (5 U.S.C. 553) contains a ``good cause'' exemption which... LIABILITY 0 1. The authority citation for part 254 continues to read as follows: Authority: 49 U.S.C....

  11. 77 FR 15576 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-03-16

    ... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue SW... PROCEDURES 0 1. The authority citation for part 97 continues to read as follows: Authority: 49 U.S.C....

  12. 75 FR 54769 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-09-09

    ... Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  13. 77 FR 44472 - Safety Zone; Port Valdez, Alaska Maritime Highway System Ferry Terminal

    Science.gov (United States)

    2012-07-30

    ...) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to...--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues...

  14. UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

    DEFF Research Database (Denmark)

    Bao, Jianqiang; Vitting-Seerup, Kristoffer; Waage, Johannes;

    2016-01-01

    During transcription, most eukaryotic genes generate multiple alternative cleavage and polyadenylation (APA) sites, leading to the production of transcript isoforms with variable lengths in the 3' untranslated region (3'UTR). In contrast to somatic cells, male germ cells, especially pachytene...

  15. Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis

    DEFF Research Database (Denmark)

    Brandt, Christian; Frimodt-Moller, N; Lundgren, Jens Dilling

    2006-01-01

    OBJECTIVE: Bacteraemia concomitant with meningitis has been shown to greatly affect outcome. Consequently, the efficacy of serotype-specific anti-pneumococcal antiserum (APAS) was investigated in a rat model of pneumococcal meningitis. METHODS: Rats were infected with Streptococcus pneumoniae...... serotype 3. All rats received ceftriaxone starting 26 h post-infection. APAS was administered either at the time of infection or 26 h post-infection and effects were compared with rats treated with antibiotics only. RESULTS AND CONCLUSION: A significant clinical benefit was found when APAS was given...... at the time of infection whereas no effect was found when administered 26 h after infection. This work indicates that the clinical value of using APAS in pneumococcal meningitis may be limited...

  16. Probability as certainty: dichotomous thinking and the misuse of p values.

    Science.gov (United States)

    Hoekstra, Rink; Finch, Sue; Kiers, Henk A L; Johnson, Addie

    2006-12-01

    Significance testing is widely used and often criticized. The Task Force on Statistical Inference of the American Psychological Association (TFSI, APA; Wilkinson & TFSI, 1999) addressed the use of significance testing and made recommendations that were incorporated in the fifth edition of the APA Publication Manual (APA, 2001). They emphasized the interpretation of significance testing and the importance of reporting confidence intervals and effect sizes. We examined whether 286 Psychonomic Bulletin & Review articles submitted before and after the publication of the TFSI recommendations by APA complied with these recommendations. Interpretation errors when using significance testing were still made frequently, and the new prescriptions were not yet followed on a large scale. Changing the practice of reporting statistics seems doomed to be a slow process.

  17. Depression - resources

    Science.gov (United States)

    Resources - depression ... Depression is a medical condition. If you think you may be depressed, see a health care provider. ... following organizations are good sources of information on depression : American Psychological Association -- www.apa.org/topics/depress/ ...

  18. Estonian President Ilves: Euro introduction was a "fantastic idea"

    Index Scriptorium Estoniae

    2011-01-01

    President Toomas Hendrik Ilves nõudis Viinis maailmapoliitika konverentsi ajal uudisteagentuurile APA antud usutluses rangemat rahanduspoliitilist distsipliini.Visiit Šveitsi ja Austriasse 07.12.2011 - 11.12.2011

  19. 50 CFR 600.15 - Other acronyms.

    Science.gov (United States)

    2010-10-01

    ...) TAC—total allowable catch (15) TALFF—total allowable level of foreign fishing (b) Legislation. (1) APA... Advisory Committee Act (5) FOIA—Freedom of Information Act (6) FLSA—Fair Labor Standards Act (7)...

  20. 77 FR 66535 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-11-06

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue...

  1. 78 FR 28135 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-05-14

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue...

  2. 75 FR 69331 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-11-12

    ... Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle...: Final rule. SUMMARY: This establishes, amends, suspends, or revokes Standard Instrument Approach... Center (APA-200), FAA Headquarters Building, 800 Independence Avenue, SW., Washington, DC 20591; or...

  3. 78 FR 50324 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-08-19

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue...

  4. 6 CFR 27.105 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... STANDARDS General § 27.105 Definitions. As used in this part: A Commercial Grade (ACG) shall refer to any..., stores, manufactures, or ships. A Placarded Amount (APA) shall refer to the STQ for a sabotage...

  5. 76 FR 77111 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-12-12

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence...

  6. 78 FR 7650 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-02-04

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue...

  7. Stress in childhood

    Science.gov (United States)

    ... of stress in your children and teens. www.apa.org/helpcenter/stress-children.aspx . Accessed July 8, ... verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. ...

  8. 78 FR 68702 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-11-15

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue...

  9. 78 FR 78713 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-12-27

    ... Federal Aviation Administration 14 CFR Part 97 Standard Instrument Approach Procedures, and Takeoff... Standard Instrument Approach Procedures (SIAPs) and associated Takeoff Minimums and Obstacle Departure... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue...

  10. After an Attempt: A Guide for Taking Care of Your Family Member After Treatment in the Emergency Department

    Science.gov (United States)

    ... Association A national professional organization of psychologists. www.apa.org or call 1-800-374-2721 Befrienders ... 30 a.m. to 12 a.m. Eastern Standard Time to answer mental health questions. www.mentalhealth. ...

  11. Vibrational, spectroscopic, molecular docking and density functional theory studies on N-(5-aminopyridin-2-yl)acetamide

    Science.gov (United States)

    Asath, R. Mohamed; Rekha, T. N.; Premkumar, S.; Mathavan, T.; Benial, A. Milton Franklin

    2016-12-01

    Conformational analysis was carried out for N-(5-aminopyridin-2-yl)acetamide (APA) molecule. The most stable, optimized structure was predicted by the density functional theory calculations using the B3LYP functional with cc-pVQZ basis set. The optimized structural parameters and vibrational frequencies were calculated. The experimental and theoretical vibrational frequencies were assigned and compared. Ultraviolet-visible spectrum was simulated and validated experimentally. The molecular electrostatic potential surface was simulated. Frontier molecular orbitals and related molecular properties were computed, which reveals that the higher molecular reactivity and stability of the APA molecule and further density of states spectrum was simulated. The natural bond orbital analysis was also performed to confirm the bioactivity of the APA molecule. Antidiabetic activity was studied based on the molecular docking analysis and the APA molecule was identified that it can act as a good inhibitor against diabetic nephropathy.

  12. The Role of Statistics and Research Methods in the Academic Success of Psychology Majors: Do Performance and Enrollment Timing Matter?

    Science.gov (United States)

    Freng, Scott; Webber, David; Blatter, Jamin; Wing, Ashley; Scott, Walter D.

    2011-01-01

    Comprehension of statistics and research methods is crucial to understanding psychology as a science (APA, 2007). However, psychology majors sometimes approach methodology courses with derision or anxiety (Onwuegbuzie & Wilson, 2003; Rajecki, Appleby, Williams, Johnson, & Jeschke, 2005); consequently, students may postpone…

  13. Faculty application of the American Psychological Association style.

    Science.gov (United States)

    Morse, Gwen Goetz

    2009-10-01

    This article explores current faculty methods with the application and evaluation of the American Psychological Association (APA) style. Specific aims were to determine concerns related to APA style, review faculty grading practices, identify institutional resources, and report potential solutions for improving application of APA style. A survey with an exploratory descriptive research design was developed and distributed online to academic chairs and deans, requesting their support in distributing the survey to their faculty. Responses (N = 704) were grouped into five categories: departmental and personal concerns; faculty grading practices; institutional resources; format, writing style, and grammar; and suggestions and potential solutions. Sixty percent reported that application and evaluation of APA style is a concern in their department. Content analysis identified four categories as proposed solutions: consistency, education, resources, and dialogue. On the basis of the feedback of the participants, the CRED program is proposed for the issues that were identified.

  14. Guidelines for psychological evaluations in child protection matters.

    Science.gov (United States)

    2013-01-01

    The problems of abused and neglected children are epidemic in our society (U.S. Department of Health and Human Services, Administration on Children, Youth, and Families, 2008) and create issues that psychologists may be called upon to address. Psychologists are positioned to contribute significantly to decision making in child protection matters. Psychological data and expertise may provide sources of information and a perspective not otherwise available to courts regarding the functioning of parties, and thus may increase the fairness of decisions by the court, state agency, or other party. such matters. These guidelines are a revision of the 1999 "Guidelines for Psychological Evaluations in Child Protection Matters" (American Psychological Association [APA], 1999). These guidelines are informed by APA's "Ethical Principles of Psychologists and Code of Conduct" ("APA Ethics Code"; APA, 2002a, 2010).

  15. Phenomenology and adapted physical activity: philosophy and professional practice.

    Science.gov (United States)

    Standal, Øyvind F

    2014-01-01

    Through the increased use of qualitative research methods, the term phenomenology has become a quite familiar notion for researchers in adapted physical activity (APA). In contrast to this increasing interest in phenomenology as methodology, relatively little work has focused on phenomenology as philosophy or as an approach to professional practice. Therefore, the purpose of this article is to examine the relevance of phenomenology as philosophy and as pedagogy to the field of APA. First, phenomenology as philosophy is introduced through three key notions, namely the first-person perspective, embodiment, and life-world. The relevance of these terms to APA is then outlined. Second, the concept of phenomenological pedagogy is introduced, and its application and potential for APA are discussed. In conclusion, it is argued that phenomenology can help theorize ways of understanding human difference in movement contexts and form a basis of action-oriented research aiming at developing professional practice.

  16. Antiphospholipid Antibody and Antiphospholipid Syndrome

    Institute of Scientific and Technical Information of China (English)

    吴竞生

    2008-01-01

    @@ Antiphospholipid antibodies (APA) APA is a big category for all kinds of negative charge phospholipid or lecithin - a protein complex autoantibodies or the same antibody, through its recognition of antigen (target protein) different, and phospholipids or lecithin - protein complex combination of various rely on the interference Phospholipid clotting and anti-coagulation factor, and promote endothelial cells, platelets, complement activation and play a role. APA including lupus anticoagulant(LA) and anticardiolipin antibody (ACA), In addition, there are anti-β2 glycoprotein-I (β2-GPI) antibody, anti-prothrombin (a- PT) antibody, anti-lysophosphatidic acid antibody and anti-phosphatidylserine antibody, and so on. APA as the main target of phospholipid-binding protein, including β2-GPI, prothrombin, annexin, protein C (PC) and protein S (PS), plasminogen, and so on.

  17. Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

    Science.gov (United States)

    Janecka, M; Mill, J; Basson, M A; Goriely, A; Spiers, H; Reichenberg, A; Schalkwyk, L; Fernandes, C

    2017-01-01

    Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders. PMID:28140401

  18. Alterations in polyadenylation and its implications for endocrine disease

    DEFF Research Database (Denmark)

    Rehfeld, Anders Aagaard; Plass, Mireya; Krogh, Anders

    2013-01-01

    Introduction: Polyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation. Genes with multiple poly(A) sites can undergo alternative polyadenylation (APA), producing distinct mRNA isoforms with dif......Introduction: Polyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation. Genes with multiple poly(A) sites can undergo alternative polyadenylation (APA), producing distinct mRNA isoforms...... with different 3' untranslated regions (3' UTRs) and in some cases different coding regions. Two thirds of all human genes undergo APA. The efficiency of the polyadenylation process regulates gene expression and APA plays an important part in post-transcriptional regulation, as the 3' UTR contains various cis...

  19. The role of alternative polyadenylation in the antiviral innate immune response

    Science.gov (United States)

    Jia, Xin; Yuan, Shaochun; Wang, Yao; Fu, Yonggui; Ge, Yong; Ge, Yutong; Lan, Xihong; Feng, Yuchao; Qiu, Feifei; Li, Peiyi; Chen, Shangwu; Xu, Anlong

    2017-01-01

    Alternative polyadenylation (APA) is an important regulatory mechanism of gene functions in many biological processes. However, the extent of 3′ UTR variation and the function of APA during the innate antiviral immune response are unclear. Here, we show genome-wide poly(A) sites switch and average 3′ UTR length shortens gradually in response to vesicular stomatitis virus (VSV) infection in macrophages. Genes with APA and mRNA abundance change are enriched in immune-related categories such as the Toll-like receptor, RIG-I-like receptor, JAK-STAT and apoptosis-related signalling pathways. The expression of 3′ processing factors is down-regulated upon VSV infection. When the core 3′ processing factors are knocked down, viral replication is affected. Thus, our study reports the annotation of genes with APA in antiviral immunity and highlights the roles of 3′ processing factors on 3′ UTR variation upon viral infection. PMID:28233779

  20. Præsentationsformater for bibliografier, publikationslister og andre referencer

    DEFF Research Database (Denmark)

    Wille, Niels Erik

    Vejledning i udformning af teksthenvisninger og referencelister, med et udvalg af eksempler fra de mest udbredte "systemer": F.eks. Dansk Standard, Modern Language Aasociation (MLA), American Psychological Association (APA), Modern Humanities Research Association (MHRA), Chicago Manual of Style...

  1. [Development and differentiation of the rat epididymis. II: histochemical aspects of the peritubular zone].

    Science.gov (United States)

    Francavilla, F; Santiemma, V; Francavilla, S; Forcella, G; Moscardelli, S; Properzi, G

    1979-07-15

    Development of the contractile peritubular structures of rat testis, from birth to full maturation, was investigated by histochemical evaluation of alkaline phosphatase activity (A.P.A.) at 0, 16, 22 e 35 days of age. A.P.A. appeared at 6 days, age of appearance also of the cytoplasmic microfilaments of peritubular cells. The correlation between cytoplasmic microfilaments and A.P.A. was confirmed by the pattern of A.P.A. positivity at 6 degree day, when the inner peritubular cells layer, in which the microfilaments are present, are more positive than the outer layer in which the microfilaments are not yet present. These findings give further support to the belief that the cytoplasmic microfilaments of peritubular cells are contractile structures.

  2. 76 FR 4938 - Kermit B. Gosnell, M.D.; Decision and Order

    Science.gov (United States)

    2011-01-27

    ... expired on September 30, 2010. \\2\\ Under the Administrative Procedure Act (APA), an agency ``may take..., Attorney General's Manual on the Administrative Procedure Act 80 (1947) (Wm. W. Gaunt & Sons, Inc.,...

  3. Helping Yourself Heal: A Recovering Man's Guide to Coping with the Effects of Childhood Abuse

    Science.gov (United States)

    ... Information, http: / / www. healthyminds. org ■ American Psychological Association Psychology Help Center, http: / / www. apa. org/ helpcenter/ index. ... 410-893-3322 8 Notes ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ ____________________________________________________ [Room here for clinic sticker and list of local resources] HHS Publication ...

  4. What Is Psychiatry?

    Medline Plus

    Full Text Available ... APA's Diagnostic and Statistical Manual of Mental Disorders ( DSM-5 ), which contains descriptions, symptoms and other criteria ... An Expert Share Your Story Your Guide to DSM-5 A Addiction and Substance Use Disorders Alzheimer's ...

  5. Diagnosis and treatment of atypical polypoid adenomyoma of uterus%子宫非典型息肉样腺肌瘤诊治分析

    Institute of Scientific and Technical Information of China (English)

    叶明侠; 彭红梅; 黄柯; 李立安; 孟元光; 李亚里

    2013-01-01

    Objective To study the clinical characteristics, diagnosis and treatment of atypical polypoid adenomyoma (APA) of uterus. Methods Clinical data about 13 patients with APA of uterus admitted to our hospital from January 2006 to October 2011 were retrospectively analyzed. Results APA usually occurred in premenopausal women and mainly manifested as irregular menstrual bleeding and infertility. Of the 13 patients, 6 underwent total hysterectomy and were followed up for 67 months during which no abnormality was observed, 5 received hysteroscopic tumor resection and curettage, 3 was pathologically diagnosed with APA and received no further treatment, 2 was pathologically diagnosed with low malignant potential APA and treated with progestogen with relapse in 1 who was not pregnant after treatment. No malignancy was found in all patients. Conclusion APA is a benign tumor with a good prognosis. It may potentially become malignant and can be surgically removed with fertility reserved and treated with progestogen. APA patients should be regularly followed up. Surgery and hysteroscopy are recommended for its reexamination.%  目的探讨子宫非典型息肉样腺肌瘤(atypical polypoid adenomyoma,APA)的临床特点、诊断及治疗.方法回顾性分析我院2006年1月-2011年10月住院治疗的13例APA患者临床诊疗情况及结局.结果 APA多发于绝经前,主要临床表现为不规则阴道流血及不孕.6例全子宫切除患者,随访至今,最长67个月,定期复查未见异常.5例宫腔镜下肿物切除+诊刮患者,3例病理为APA,未行进一步治疗,单纯随访未见异常.2例病理为低恶性潜能APA(atypical polypoid adenomyoma of low malignant potential,APA-LMP),给予孕激素治疗,其中1例复发,均给予助孕治疗,尚未妊娠.所有患者无恶变.结论 APA是一种良性病变,多数预后良好;但有恶性潜能,可以行保留生育功能的手术,同时辅以孕激素治疗,严格随诊;手术及复查推荐宫腔镜.

  6. Training Aide: Research and Guidance for Effective Training User Guide

    Science.gov (United States)

    2013-12-01

    etc. • Citation – Standard APA format citation including authors, year, title, and source information. • Abstract – Cut & paste from publication if...authors, publication year, citation , abstract, document type, data source, report type, and document creator (Figure 41). Hyperlinks are available...standard APA format last name, first initial. • Year – The year the document was published. • Document Type – Identifies the document source as a

  7. Blister Packaging Medication to Increase Treatment Adherence and Clinical Response: Impact on Suicide-Related Morbidity and Mortality

    Science.gov (United States)

    2013-09-01

    at the 2013 APA Annual Conversion. Data from APA Poster: N=205 The internal consistency reliability estimate (i.e., coefficient alpha) for the SHBQ...Bagge, C. L., Freedenthal, S., Gutierrez, P.M., & Lozano, G. (2012). The Depression Anxiety Stress Scales-- 21 ( DASS - 21 ): Further examination of...Entering follow-up assessment data {months 5-57) Task 6. Preparing year two quarterly reports (months 15, 18, 21 , 24) completed Task 7. Data analyses

  8. Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis

    DEFF Research Database (Denmark)

    Brandt, Christian; Frimodt-Moller, N; Lundgren, Jens Dilling;

    2006-01-01

    OBJECTIVE: Bacteraemia concomitant with meningitis has been shown to greatly affect outcome. Consequently, the efficacy of serotype-specific anti-pneumococcal antiserum (APAS) was investigated in a rat model of pneumococcal meningitis. METHODS: Rats were infected with Streptococcus pneumoniae...... at the time of infection whereas no effect was found when administered 26 h after infection. This work indicates that the clinical value of using APAS in pneumococcal meningitis may be limited...

  9. Covalent functionalization of graphene oxide by 9-(4-aminophenyl)acridine and its derivatives

    Institute of Scientific and Technical Information of China (English)

    Yi Si Feng; Jing Jing Ma; Xin Yan Lin; Jia Song Zhang; Peng Lv; Hua Jian Xu; Lin Bao Luo

    2012-01-01

    Graphene/acridine (G-Acr) hybrid structures were synthesized through covalent functionalization of graphene oxide with 9-(4-aminophenyl)acridine (APA) and its derivatives.The G-Acr hybrids were characterized by Fourier transform infrared spectroscopy,ultraviolet-visible spectrophotometry,thermal gravimetric analysis and Raman spectroscopy.X-ray photoelectron spectroscopy confirms that the binding energies of APA and its derivatives shifted to higher values,revealing pronounced charge transfer at the interface of graphene and organic molecules.

  10. Systems Engineering of Unmanned DoD Systems: Following the Joint Capabilities Integration and Development System/Defense Acquisition System Process to Develop an Unmanned Ground Vehicle System

    Science.gov (United States)

    2015-12-01

    Manual D-A-1). APAs are “Performance attributes of a system not important enough to be considered KPPs or KSAs, but still appropriate to include in...the CDD or CPD are designated as APAs ” (JCIDS Manual D-A-1). The requirements are expressed using Thresholds (T) and Objectives (O). “Performance...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA SYSTEMS ENGINEERING CAPSTONE PROJECT REPORT Approved for public release; distribution is

  11. Behavioral Health and Service Use Among Civilian Wives of Service Members and Veterans: Evidence from the National Survey of Drug Use and Health

    Science.gov (United States)

    2015-01-01

    Diagnostic and Statistical Manual of Mental Disorders, Version IV ( APA , 2000). The following four behavioral health service use outcomes were examined...Statistical Manual of Mental Disorders, revised 4th ed., Washington, D.C., 2000. APA —See American Psychiatric Association. Brown, Ryan Andrew, Grant N...ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for

  12. Severe non-traumatic bleeding events detected by computed tomography: do anticoagulants and antiplatelet agents have a role?

    OpenAIRE

    Risch, Olivier; Alfidja, Agaicha; Mulliez, Aurelien; Amani, Anderson H.; Boyer, Louis; Camilleri, Lionel; Azarnoush, Kasra

    2014-01-01

    Purpose: Bleeding is the most common and most serious complication of anticoagulant (AC) and antiplatelet agents (APA) which are increasingly used in every day practice. The aim of this study was to enlist and analyze the most severe bleeding events revealed during computed tomography scanner (CT scan) examinations over a 1-year period at our University Hospital and to evaluate the role of ACs and APAs in their occurrence. Methods: This descriptive monocentric retrospective study included all...

  13. Improvement of anticipatory postural adjustments for balance control: effect of a single training session

    OpenAIRE

    Kanekar, Neeta; Aruin, Alexander S.

    2014-01-01

    Humans use anticipatory and compensatory postural strategies to maintain and restore balance when perturbed. Inefficient generation and utilization of anticipatory postural adjustments (APAs) is one of the reasons for postural instability. The aim of the study was to investigate the role of training in improvement of APAs and its effect on subsequent control of posture. Thirteen healthy young adults were exposed to predictable external perturbations before and after a single training session ...

  14. The organization of anticipatory postural adjustments

    OpenAIRE

    Aruin Alexander S.

    2002-01-01

    Central control of posture is expressed through anticipatory and compensatory postural adjustments. Anticipatory postural adjustments (APAs) precede planned postural perturbations and minimize them with anticipatory corrections, while compensatory postural adjustments deal with actual perturbations of balance that occur as a result of suboptimal efficiency of anticipatory corrections. The process of generation of APAs is affected by three major factors: expected magnitude and direction of the...

  15. SupportNet for Frontline Behavioral Health Providers

    Science.gov (United States)

    2015-07-01

    and Coping. Accepted for publication. 5 Conference presentations completed (in chronological order; Objectives 2 & 3): d) Poster presented at APA ...adherence. The current study sought to standardize the eHealth readiness scale, implemented to examine individual characteristics assessing participant...increase dissemination of our findings. d) Attended five conferences to present SupportNet findings (Objective 3): APA (August 2014), Medicine 2.0

  16. Mischievous responding in Internet Gaming Disorder research

    OpenAIRE

    Przybylski, Andrew K.

    2016-01-01

    The most recent update to the American Psychiatric Association’s (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) included Internet Gaming Disorder as a new potential psychiatric condition that merited further scientific study. The present research was conducted in response to the APA Substance-Related Disorders Working Group’s research call to estimate the extent to which mischievous responding—a known problematic pattern of participant self-report responding in questionna...

  17. New concepts, old known issues - the DSM-5 and Internet Gaming Disorder and its assessment [forthcoming

    OpenAIRE

    Pontes, HM; Griffiths, MD

    2015-01-01

    Background: Following the growing concern about 'internet gaming addiction', the American Psychiatric Association (APA) and numerous scholars have suggested the need for unification and consensus for the assessment of gaming addiction, which is now possible given the recent formal recognition of 'internet gaming disorder' (IGD) by the APA since its inclusion in the DSM-5. Aims: In light of this, the aim of this chapter is to present the main findings concerning the development of the Internet...

  18. Instrucciones para autores y autoras

    OpenAIRE

    Casa de la Mujer, Revista

    2015-01-01

    Le recomendamos leer este documento a profundidad para queconozca las políticas y normas para postular a consideración su escrito.Estas instrucciones se organizan en tres apartados: I. Datos básicos,II. Políticas y III. Lineamientos para presentar el escrito; para la citacióny referenciación con APA se ofrece el documento titulado Guía dereferenciación y citación con APA.

  19. Updating the treatment of recurrent tonsillitis in adults. Review

    OpenAIRE

    Gascón-Rubio, María Cristina; Alonso-Alonso, Albino José

    2016-01-01

    Introduction and Objectives: Acute pharyngitis in adults (APA) is one of the most frequent reasons for consultation in primary care. The main objective of this review is to update the therapeutic options for the prevention and treatment of APA and to determine which interventions have the greatest impact in reducing morbidity and improving the quality of life of patients, which directly affects the consumption of health resources. Material and Methods: First clinical criteria of the FAA, indi...

  20. RAGAM PERSFEKTIF PARTISIPASI MASYARAKAT DALAM PEMBANGUNAN DESA

    OpenAIRE

    Sakaria J Anwar

    2015-01-01

    -- Sebelum kita menelaah apa dan bagaimana dengan pembangunan terlebih dahulu harus dimengerti apa ilu desa dan pembanguan itu Untuk mengetahui dan mengerti defenisi desa, mari kita simak pendapat dan beberapa ahli berikut: Sutardjo Kartohadikusumo (1953) mengemukakan desa adalah suatu kesatuan hukum dimana bertempat tinggal suatu masyarakat yang berkuasa mengadakan pemerintahan sendiri. Secara panjang lebar Prof. Drs. Bintarto (1983) mengatakan desa adalah suatu hasil perpaduan antara sek...

  1. Gender difference in academic planning activity among medical students.

    Directory of Open Access Journals (Sweden)

    Huy Van Nguyen

    Full Text Available BACKGROUND: In Vietnam, as doctor of medicine is socially considered a special career, both men and women who are enrolled in medical universities often study topics of medicine seriously. However, as culturally expected, women often perform better than men. Because of this, teaching leadership and management skill (LMS to develop academic planning activity (APA for female medical students would also be expected to be more effective than male counterparts. This research aimed to compare by gender the effect of teaching LMS on increasing APA, using propensity score matching (PSM. METHODS: In a cross-sectional survey utilizing a self-reported structured questionnaire on a systematic random sample of 421 male and female medical students in Hanoi Medical University, this study adopted first regression techniques to construct a fit model, then PSM to create a matched control group in order to allow for evaluating the effect of LMS education. RESULTS: There were several interesting gender differences. First, while for females LMS education had both direct and indirect effects on APA, it had only direct effect on males' APA. Second, after PSM to adjust for the possible confounders to balance statistically two groups - with and without LMS education, there is statistically a significant difference in APA between male and female students, making a net difference of 11% (p<.01, equivalent to 173 students. The difference in APA between exposed and matched control group in males and females was 9% and 20%, respectively. These estimates of 9.0 and 20.0 percentage point increase can be translated into the practice of APA by 142 males and 315 females, respectively, in the population. These numbers of APA among male and female students can be explained by LMS education. CONCLUSIONS: Gender appears to be a factor explaining in part academic planning activity.

  2. Changes of pain behavior and expression of N-methyl-D-aspartate receptor in spinal dorsal horn after intrathecal transplantation of microcapsulized transplant-enkephalin cells in rat%鞘内移植微囊化转前脑啡肽原基因细胞对大鼠痛行为及脊髓背角相关蛋白表达的影响

    Institute of Scientific and Technical Information of China (English)

    曹靖; 王振全; 任秀花; 臧卫东

    2010-01-01

    目的:观察海藻酸钠-聚赖氨酸-海藻酸钠(APA)微囊化转鼠前脑啡肽原基因NIH3T3细胞(APA-NIH3T3/rPENK)移植对大鼠神经痛的影响及相关机制.方法:制作SD大鼠坐骨神经慢性压迫模型(CCI),随机分为APA空囊组、NIH3T3/rPENK组和APA-NIH3T3/rPENK组.测定移植后各组CCI术侧热痛阈,大鼠脊髓背角N-甲基-D-天冬氨酸受体2B亚基(NR2B)蛋白的表达情况.结果:移植后NIH3T3/rPENK组和APA-NIH3T3/rPENK组热痛阈明显高于APA空囊组.移植15d后APA-NIH3T3/rPENK组热痛阈显著高于NIH3T3/rPEN组.NIH3T3/rPENK组、 APA-NIH3T3/rPENK组结扎侧背角NR2B蛋白表达低于APA组;APA-NIH3T3/rPENK组背角NR2B蛋白表达低于NIH3T3/rPENK组.结论:NIH3T3/RPENK或APA-NIH3T3/rPENK植入大鼠的蛛网膜下腔可以明显减轻神经痛大鼠的热痛敏感行为,并降低脊髓背角NR2B蛋白的表达.

  3. Influence of chronic ethanol intake on mouse synaptosomal aspartyl aminopeptidase and aminopeptidase A: relationship with oxidative stress indicators.

    Science.gov (United States)

    Mayas, María Dolores; Ramírez-Expósito, María Jesús; García, María Jesús; Carrera, María Pilar; Martínez-Martos, José Manuel

    2012-08-01

    Aminopeptidase A (APA) and aspartyl aminopeptidase (ASAP) not only act as neuromodulators in the regional brain renin-angiotensin system, but also release N-terminal acidic amino acids (glutamate and aspartate). The hyperexcitability of amino acid neurotransmitters is responsible for several neurodegenerative processes affecting the central nervous system. The purpose of the present work was to study the influence of chronic ethanol intake, a well known neurotoxic compound, on APA and ASAP activity under resting and K(+)-stimulated conditions at the synapse level. APA and ASAP activity were determined against glutamate- and aspartate-β-naphthylamide respectively in mouse frontal cortex synaptosomes and in their incubation supernatant in a Ca(2+)-containing or Ca(2+)-free artificial cerebrospinal fluid. The neurotoxic effects were analyzed by determining free radical generation, peroxidation of membrane lipids and the oxidation of synaptosomal proteins. In addition, the bioenergetic behavior of synaptosomes was analyzed under different experimental protocols. We obtained several modifications in oxidative stress parameters and a preferential inhibitor effect of chronic ethanol intake on APA and ASAP activities. Although previous in vitro studies failed to show signs of neurodegeneration, these in vivo modifications in oxidative stress parameters do not seem to be related to changes in APA and ASAP, invalidating the idea that an excess of free acidic amino acids released by APA and ASAP induces neurodegeneration.

  4. The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes

    Science.gov (United States)

    Wu, Vin-Cent; Wang, Shuo-Meng; Chueh, Shih-Chieh Jeff; Yang, Shao-Yu; Huang, Kuo-How; Lin, Yen-Hung; Wang, Jian-Jhong; Connolly, Rory; Hu, Ya-Hui; Gomez-Sanchez, Celso E.; Peng, Kang-Yung; Wu, Kwan-Dun

    2017-01-01

    Constitutive activation of the Wnt pathway/β-catenin signaling may be important in aldosterone-producing adenoma (APA). However, significant gaps remain in our understanding of the prevalence and clinical outcomes after adrenalectomy in APA patients harboring CTNNB1 mutations. The molecular expression of CYP11B2 and gonadal receptors in adenomas were also explored. Adenomas from 219 APA patients (95 men; 44.2%; aged 50.5 ± 11.9 years) showed a high rate of somatic mutations (n = 128, 58.4%). The majority of them harbored KCNJ5 mutations (n = 116, 52.9%); 8 patients (3.7%, 6 women) had CTNNB1 mutations. Patients with APAs harboring CTNNB1 mutations were older and had shorter duration of hypertension. After adrenalectomy, CTNNB1 mutation carriers had a higher possibility (87.5%) of residual hypertension than other APA patients. APAs harboring CTNNB1 mutations have heterogeneous staining of β-catenin and variable expression of gonadal receptors and both CYP11B1 and CYP11B2. This suggests that CTNNB1 mutations may be more related to tumorigenesis rather than excessive aldosterone production. PMID:28102204

  5. Amoebapore is an important virulence factor of Entamoeba histolytica

    Indian Academy of Sciences (India)

    Rivka Bracha; Yael Nuchamowitz; David Mirelman

    2002-11-01

    We have previously demonstrated that inhibition of expression of amoebapore A (AP-A) by antisense RNA caused a marked decrease in the virulence of the parasite. A four-fold over-expression of AP-A was obtained with plasmid (pA7) which has the ap-a gene under the control of gene EhgLE-3-RP-L21. The virulence of the transfected trophozoites, however, was also decreased. Excess of AP-A protein was found in the cytosol and a significant amount was released into the surrounding media. Transfection of the parasite with a plasmid (psAP-1) in which the ap-a gene was introduced with its own regulatory sequences, caused a total suppression of the transcription and translation of both the genomic and episomal ap-a genes. The silenced transfectant was not virulent at all. These results demonstrate that important factors need to be expressed at the correct cellular location and that the parasite has additional internal control mechanisms such as transcriptional gene silencing which can prevent excess amounts of gene expression.

  6. Anticipatory postural adjustments in children with hemiplegia and diplegia.

    Science.gov (United States)

    Girolami, Gay L; Shiratori, Takako; Aruin, Alexander S

    2011-12-01

    Anticipatory postural adjustments (APAs) play an important role in the performance of many activities requiring the maintenance of standing posture. However, little is known about if and how children with cerebral palsy (CP) generate APAs. Two groups of children with CP (hemiplegia and diplegia) and a group of children with typical motor development performed arm flexion and extension movements while standing on a force platform. Electromyographic activity of six trunk and leg muscles and displacement of center of pressure (COP) were recorded. Children with CP were able to generate anticipatory postural adjustments and produce directionally specific APAs and COP displacements similar to those described in adults and typically developing children. However, children with diplegia were unable to generate APAs of the same magnitude as children with typical development and hemiplegia and had higher baseline muscle activity prior to movement. In children with diplegia, COP was posteriorly displaced and peak acceleration was smaller during bilateral extension compared to children with hemiplegia. The outcomes of the study highlight the role of APAs in the control of posture of children with CP and point out the similarities and differences in anticipatory control in children with diplegia and hemiplegia. These differences may foster ideas for treatment strategies to enhance APAs in children with CP.

  7. Influence of fear of falling on anticipatory postural control of medio-lateral stability during rapid leg flexion.

    Science.gov (United States)

    Yiou, E; Deroche, T; Do, M C; Woodman, T

    2011-04-01

    During leg flexion from erect posture, postural stability is organized in advance during "anticipatory postural adjustments" (APA). During these APA, inertial forces are generated that propel the centre of gravity (CoG) laterally towards stance leg side. This study examined how fear of falling (FoF) may influence this anticipatory postural control of medio-lateral (ML) stability. Ten young healthy participants performed a series of leg flexions at maximal velocity from low and high surface heights (6 and 66 cm above ground, respectively). In this latter condition with increased FoF, stance foot was placed at the lateral edge of the support surface to induce maximal postural threat. Results showed that the amplitude of ML inertial forces generated during APA decreased with FoF; this decrease was compensated by an increase in APA duration so that the CoG position at time of swing foot-off was located further towards stance leg side. With these changes in ML APA, the CoG was propelled in the same final (unipodal) position above stance foot as in condition with low FoF. These results contrast with those obtained in the literature during quiet standing which showed that FoF did not have any influence on the ML component of postural control. It is proposed that ML APA are modified with increased FoF, in such a way that the risk of a sideway fall induced by the large CoG motion is attenuated.

  8. Aging and balance control in response to external perturbations: role of anticipatory and compensatory postural mechanisms.

    Science.gov (United States)

    Kanekar, Neeta; Aruin, Alexander S

    2014-06-01

    The ability to maintain balance deteriorates with increasing age. Anticipatory and compensatory postural adjustments (APAs and CPAs, respectively), both, are known to be affected in the elderly. We examined the effect of aging on the ability of older adults to utilize APAs and its effect on subsequent control of posture (CPAs). Ten elderly individuals were exposed to external predictable and unpredictable perturbations applied to the upper body in the sagittal plane. Body kinematics, electromyographic activity of 13 muscles, and ground reaction forces were analyzed during the anticipatory and compensatory phases of postural control. The elderly were capable of recognizing an upcoming predictable perturbation and activated muscles prior to it. However, the older adults used different muscle strategies and sequence of muscle recruitment than that reported in young adults. Additionally, when the perturbations were unpredictable, no APAs were seen which resulted in large CPAs and greater peak displacements of the center of pressure (COP) and center of mass (COM) following perturbations. As opposed to this, when the perturbations were predictable, APAs were seen in older adults resulting in significantly smaller CPAs. The presence and utilization of APAs in older adults also improved postural stability following the perturbation as seen by significantly smaller COP and COM peak displacements. Using APAs in older adults significantly reduces the need for large CPAs, resulting in greater postural stability following a perturbation. The results provide a foundation for investigating the role of training in improving the interplay between anticipatory and compensatory postural control in older adults.

  9. Anticipatory postural adjustments associated with a loading perturbation in children with hemiplegic and diplegic cerebral palsy.

    Science.gov (United States)

    Shiratori, T; Girolami, G L; Aruin, A S

    2016-10-01

    Anticipatory postural adjustments (APAs) in preparation for predictable externally induced loading perturbation were studied in children with typically development (TD), hemiplegic (HEMI), and diplegic (DIPL) cerebral palsy. Twenty-seven children (n = 9 in each group) were asked to stand and catch a load dropped from a pre-specified height. Electrical activity of the leg and trunk muscles and center of pressure (COP) displacements were recorded to quantify the APAs. All groups were able to generate APAs prior to the perturbation, but the magnitude was smaller and the onset was delayed in the dorsal (agonist) postural muscles in both HEMI and DIPL as compared to TD. HEMI and DIPL also generated APAs in the antagonist postural muscles. Anticipatory backward COP displacement was significantly different from the baseline value only in the TD and HEMI. HEMI and DIPL displayed a different postural control strategy; HEMI showed no difference in background postural activity from TD, but with diminished APAs in the agonist postural muscles compared to TD, while DIPL showed a higher background postural activity and diminished APAs in the agonist postural muscles compared to TD. These differences are important to consider when designing rehabilitation programs to improve posture and movement control in children with hemiplegic and diplegic cerebral palsy.

  10. Kinetic studies on the carboxylation of 6-amino-penicillanic acid to 8-hydroxy-penillic acid

    DEFF Research Database (Denmark)

    Henriksen, Claus Maxel; Holm, SS; Schipper, D.

    1997-01-01

    The carboxylation in aqueous solution of 6-amino-penicillanic acid (6-APA) to 8-hydroxy-penillic acid (8-HPA) was studied at 25 degrees C and pH 6.5. During sparging with either a citrate buffer or a chemically defined cultivation medium containing 6-APA with mixtures of carbon dioxide and air (2.......7-41% (v/v) CO2), the kinetics for conversion of 6-APA was followed by HPLC. In the citrate buffer 6-APA was converted by two competitive reactions each following first order kinetics with respect to the concentration of 6-APA: 1. carboxylation into 8-HPA; and 2. slow conversion into an unknown compound....... Formation of the unknown compound was not observed in the cultivation medium. The carboxylation of 6-APA was also found to be first order with respect to the concentration of dissolved carbon dioxide. The rate constant for formation of 8-HPA did not differ significantly in the cultivation medium compared...

  11. 改良APACHE评分系统对血栓性急症的临床应用

    Institute of Scientific and Technical Information of China (English)

    陈凯

    2008-01-01

    目的:探讨改良APA CHE评分系统对血栓性急症的临床应用.方法:采用改良APA CHEⅡ评分系统在急诊内科患者进行评分,根据分值分层比较各组缓解率、住院率和病死率,对生存组和死亡组的评分进行比较.结果:根据改良APA CHEⅡ评分进行分组后,随着改良APA CHEⅡ评分,病死率也逐渐升高,APA CHEⅡ评分均值高于急症组,差异具有统计学意义.结论:采用改良APA CHEⅡ评分系统对急诊内科患者评估,对血栓性急症能够判断病情和估计预后,而且简便、快捷,适合急诊应用.

  12. Should title lengths really adhere to the American Psychological Association's twelve word limit?

    Science.gov (United States)

    Hallock, Robert M; Dillner, Kari M

    2016-04-01

    The publication manual for the American Psychological Association (APA) suggests that title lengths do not exceed 12 words, yet journals do not prevent longer titles. Here, we examined title lengths in APA journals to see how many exceeded the APA's suggested limit. First, we conducted a systematic analysis of 235 articles in the current issues of 23 APA journals. A total of 52% of titles were more than 12 words long. Second, we examined articles from APA journals that were at least 50 years old to examine whether title lengths have changed over time. Our results suggested that the average title lengths have indeed increased with time. One of 2 courses should be taken. Perhaps science is becoming more complex that longer titles are needed in order to convey the primary message to the reader. If this is the case, then the APA's word limit should be increased. On the other hand, however, maybe editor and reviewers should try to enforce the current word limit to force writers to be succinct. Either way, editors should make their preferences clear so that the trend for longer titles does not continue unchecked.

  13. Uterine arterial resistance index and auto-immune disease in patients with recurrent pregnancy loss%自身抗体阳性复发性自然流产患者的子宫动脉血流阻力变化

    Institute of Scientific and Technical Information of China (English)

    胡晶晶; 朱盈; 李国华; 洪向丽; 鲍时华; Joanne Kwak-Kim

    2015-01-01

    目的::研究自身抗体阳性的复发性自然流产(RPL)患者的子宫动脉血流阻力(U-RI)指数的变化。方法:回顾分析189例 RPL 患者(≥3)的临床资料,比较孕前自身抗体阳性和阴性患者的 U-RI 指数。结果:抗磷脂抗体(APA)阳性患者的 U-RI 明显高于APA 阴性组(P =0.018),APA-IgG 阳性组和 APA-IgA 阳性组的 U-RI 明显高于 APA 阴性组(P =0.015,P =0.030),APA-IgG、APA-IgA 阳性组的 U-RI 分别与 APA-IgG、APA-IgA 阴性组比较,差异有统计学意义(P =0.025,P =0.049),抗磷脂酸抗体(APAA)阳性组和抗磷脂酰肌醇抗体(APIA)阳性组的 U-RI 明显高于 APA 阴性组(P =0.045,P =0.048)。抗核抗体(ANA)阳性组和阴性组的 U-RI 比较,差异无统计学意义(P =0.235)。 ANA 阳性不同滴度和不同荧光核型组的 U-RI 比较,差异无统计学意义(P =0.384,P =0.181);其他抗体:anti-thyroid antibody(ATA)、dsDNA、ssDNA、Histone 及 Scl70阳性组和阴性组的 U-RI 比较,差异均无统计学意义(P>0.05)。结论:APA 阳性的 RPL 患者子宫动脉血流容易出现高阻,可能会引起子宫动脉血流灌注不足现象发生。%Objective:To investigate a possible relationship of uterine arterial resist-ance index ( U-RI) and auto-antibodies in women with recurrent pregnancy losses ( RPL).Methods:A retrospective medical record review was carried out in 189 women with RPL. Corre-lations between U-RIs and auto-antibodies were analyzed in women with RPL (≥3). Results:U-RIs were higher in RPL women with anti-phospholipid antibodies (APA) than those without APA (P =0. 018). U-RIs were higher in RPL women with APA-IgG and APA-IgA (P = 0. 015 and P =0. 030,respectively) as compared to those without APA. U-RIs of RPL women with pos-itive APA-IgG and APA-IgA were higher than those of negative APA-IgG and APA-IgA (P =0. 025 and P =0. 049,respectively). Significant differences in U-RIs were found in women with anti-phosphatidic acid antibody ( APAA) ( P = 0

  14. Anticipatory postural adjustments and anticipatory synergy adjustments: preparing to a postural perturbation with predictable and unpredictable direction.

    Science.gov (United States)

    Piscitelli, Daniele; Falaki, Ali; Solnik, Stanislaw; Latash, Mark L

    2017-03-01

    We explored two aspects of feed-forward postural control, anticipatory postural adjustments (APAs) and anticipatory synergy adjustments (ASAs) seen prior to self-triggered unloading with known and unknown direction of the perturbation. In particular, we tested two main hypotheses predicting contrasting changes in APAs and ASAs. The first hypothesis predicted no major changes in ASAs. The second hypothesis predicted delayed APAs with predominance of co-contraction patterns when perturbation direction was unknown. Healthy subjects stood on the force plate and held a bar with two loads acting in the forward and backward directions. They pressed a trigger that released one of the loads causing a postural perturbation. In different series, the direction of the perturbation was either known (the same load released in all trials) or unknown (the subjects did not know which of the two loads would be released). Surface electromyograms were recorded and used to quantify APAs, synergies stabilizing center of pressure coordinate (within the uncontrolled manifold hypothesis), and ASA. APAs and ASAs were seen in all conditions. APAs were delayed, and predominance of co-contraction patterns was seen under the conditions with unpredictable direction of perturbation. In contrast, no significant changes in synergies and ASAs were seen. Overall, these results show that feed-forward control of vertical posture has two distinct components, reflected in APAs and ASAs, which show qualitatively different adjustments with changes in predictability of the direction of perturbation. These results are interpreted within the recently proposed hierarchical scheme of the synergic control of motor tasks. The observations underscore the complexity of the feed-forward postural control, which involves separate changes in salient performance variables (such as coordinate of the center of pressure) and in their stability properties.

  15. Temporal disruption of upper-limb anticipatory postural adjustments in cerebellar ataxic patients.

    Science.gov (United States)

    Bruttini, Carlo; Esposti, Roberto; Bolzoni, Francesco; Vanotti, Alessandra; Mariotti, Caterina; Cavallari, Paolo

    2015-01-01

    Voluntary movements induce postural perturbations, which are counteracted by anticipatory postural adjustments (APAs) that preserve body equilibrium. Little is known about the neural structures generating APAs, but several studies suggested a role of sensory-motor areas, basal ganglia, supplementary motor area and thalamus. However, the role of the cerebellum still remains an open question. The aim of this present paper is to shed further light on the role of cerebellum in APAs organization. Thus, APAs that stabilize the arm when the index finger is briskly flexed were recorded in 13 ataxic subjects (seven sporadic cases, four dominant ataxia type III and two autosomal recessive), presenting a slowly progressive cerebellar syndrome with four-limb dysmetria, and compared with those obtained in 13 healthy subjects. The pattern of postural activity was similar in the two groups [excitation in triceps and inhibition in biceps and anterior deltoid (AD)], but apparent modifications in timing were observed in all ataxic subjects in which, on average, triceps brachii excitation lagged the onset of the prime mover flexor digitorum superficialis by about 27 ms and biceps and AD inhibition were almost synchronous to it. Instead, in normal subjects, triceps onset was synchronous to the prime mover and biceps and AD anticipated it by about 40 ms. The observed disruption of the intra-limb APA organization confirms that the cerebellum is involved in APA control and, considering cerebellar subjects as a model of dysmetria, also supports the view that a proper APA chain may play a crucial role in refining movement metria.

  16. Detection of anticipatory postural adjustments prior to gait initiation using inertial wearable sensors

    Directory of Open Access Journals (Sweden)

    Sekine Masaki

    2011-04-01

    Full Text Available Abstract Background The present study was performed to evaluate and characterize the potential of accelerometers and angular velocity sensors to detect and assess anticipatory postural adjustments (APAs generated by the first step at the beginning of the gait. This paper proposes an algorithm to automatically detect certain parameters of APAs using only inertial sensors. Methods Ten young healthy subjects participated in this study. The subjects wore an inertial unit containing a triaxial accelerometer and a triaxial angular velocity sensor attached to the lower back and one footswitch on the dominant leg to detect the beginning of the step. The subjects were standing upright on a stabilometer to detect the center of pressure displacement (CoP generated by the anticipatory adjustments. The subjects were asked to take a step forward at their own speed and stride length. The duration and amplitude of the APAs detected by the accelerometer and angular velocity sensors were measured and compared with the results obtained from the stabilometer. The different phases of gait initiation were identified and compared using inertial sensors. Results The APAs were detected by all of the sensors. Angular velocity sensors proved to be adequate to detect the beginning of the step in a manner similar to the footswitch by using a simple algorithm, which is easy to implement in low computational power devices. The amplitude and duration of APAs detected using only inertial sensors were similar to those detected by the stabilometer. An automatic algorithm to detect APA duration using triaxial inertial sensors was proposed. Conclusions These results suggest that the feasibility of accelerometers is improved through the use of angular velocity sensors, which can be used to automatically detect and evaluate APAs. The results presented can be used to develop portable sensors that may potentially be useful for monitoring patients in the home environment, thus

  17. Responses of Soil Acid Phosphomonoesterase Activity to Simulated Nitrogen Deposition in Three Forests of Subtropical China

    Institute of Scientific and Technical Information of China (English)

    HUANG Wen-Juan; LIU Shi-Zhong; CHU Guo-Wei; ZHANG De-Qiang; LI Yue-Lin; LU Xian-Kai; ZHANG Wei; HUANG Juan; D. OTIENO; Z. H. XU; LIU Ju-Xiu

    2012-01-01

    Soil acid phosphomonoesterase activity (APA) plays a vital role in controlling phosphorus (P) cycling and reflecting the current degree of P limitation Responses of soil APA to elevating nitrogen (N) deposition are important because of their potential applications in addressing the relationship between N and P in forest ecosystems.A study of responses of soll APA to simulated N deposition was conducted in three succession forests of subtropical China.The three forests include a Masson pine (Pinus massoniana) forest (MPF)—pioneer community,a coniferous and broad-leaved mixed forest (MF)—transition community and a monsoon evergreen broadleaved forest (MEBF)—climax community.Four N treatments were designed for MEBF:control (without N added),low-N (50 kg N ha-1 year-1),and medium-N (100 kg N ha-1 year-1) and high-N (150 kg N ha-1 year-1),and only three N treatments (i.e.,control,low-N,mediun-N) were established for MPF and MF.Results showed that soil APA was highest in MEBF.followed by MPF and MF.Soil APAs in both MPF and MF were not influenced by low-N treatments but depressed in medium-N trcatments.However,soil APA in MEBF exhibited negative responses to high N additions,indicating that the environment of enhanced N depositions would reduce P supply for the mature forest ecosystem.Soil APA and its responses to N additions in subtropical forests were closely related to the succession stages in the forests.

  18. Spatial-temporal Variations of Alkaline Phosphatase Activity in the Kuilei Lake and Their Influencing Factors%傀儡湖水体中碱性磷酸酶活性的时空变化及其影响因素

    Institute of Scientific and Technical Information of China (English)

    张成艳; 成小英; 王建军; 张路; 杜应旸

    2013-01-01

    Alkaline phosphatase activity (APA) plays an important role in the biogeochemical cycling of phosphorus.The spatial-temporal distribution of APA and related environmental variables were studied in the Kuilei Lake.The research found significant seasonal and regional variations of APA in the water body,with lower APAs in outlet waters and higher in the estuarine.APAs were relatively low in winter (January),ranging from 2.06 to 17.33 nmol mL-1 h-1,and high in summer (July),ranging from 5.78 to 13.52 nmol mL-1 h-1.Correlation analyses indicated that APAs were significantly related to particulate organic nitrogen,total nitrogen and NO2--N.Other nitrogen forms (NO3--N and NH4+-N) were also related,though not significantly.The results implied that the factors related to nitrogen are the primary factors affecting APAs.%碱性磷酸酶在磷的生物地球化学循环过程中发挥着重要作用.以傀儡湖为研究区域,对其水体中碱性磷酸酶活性(Alkaline phosphatase activity,APA)及其理化性质的时空分布进行分析.结果表明,傀儡湖水体APA呈时空异质性:河道较低,河口则易出现较高的APA;全湖的APA存在较强的季节性变化,冬季(1月)最低,变化范围为2.06-17.33nmol mL-1h-1;夏季(7月)最高,变化范围为5.78-13.52 nmol mL-1 h-1.APA与环境因子相关性分析显示,APA与颗粒态有机氮浓度关系最为密切,与总氮含量的相关性其次,随后显著相关的因子为NO2--N,此外是NO3--N和NH4+-N.这一结果表明与氮元素有关的环境因子可能是影响APA的主要因素.

  19. Directional specificity of postural threat on anticipatory postural adjustments during lateral leg raising.

    Science.gov (United States)

    Gendre, Manon; Yiou, Eric; Gélat, Thierry; Honeine, Jean-Louis; Deroche, Thomas

    2016-03-01

    This study explored the directional specificity of fear of falling (FoF) effects on the stabilizing function of anticipatory postural adjustments (APA). Participants (N = 71) performed a series of lateral leg raises from an elevated surface in three conditions: in the "Control condition", participants stood at the middle of the surface; in the two test conditions, participants were positioned at the lateral edge of the surface so that the shift of the whole-body centre-of-mass during APA for leg raising was directed towards the edge ("Approach condition") or was directed away from the edge ("Avoidance condition"). Results showed that the amplitude of APA was lower in the "Approach condition" than in the "Control condition" (p postural stability and motor performance (in terms of peak leg velocity, final leg posture and movement duration) remained unchanged. These changes in APA parameters were not present in the "Avoidance condition". Participants further self-reported a greater FoF (p Control condition". The results of this study show that the effects of FoF do not solely depend on initial environmental conditions, but also on the direction of APA relative to the location of the postural threat. These results support the so-called Motivational Direction Hypothesis, according to which approach and avoidance behaviours are primed by emotional state.

  20. Effects of lateral perturbations and changing stance conditions on anticipatory postural adjustment.

    Science.gov (United States)

    Santos, Marcio J; Aruin, Alexander S

    2009-06-01

    The study investigates the role of lateral muscles and changing stance conditions in anticipatory postural adjustments (APAs). Subjects stood laterally to an aluminum pendulum released by an experimenter and were required to stop it with their right or left hand. Stance conditions were manipulated by having the subjects stand in the following positions: on a single limb (SS), with feet together (narrow base of support, NB), and with feet shoulder width apart (regular base of support, RB). Bilateral EMG activity of dorsal, ventral, and lateral trunk and leg muscles and ground reaction forces were recorded and quantified within the time intervals typical of APAs. Anticipatory postural adjustments were seen in all experimental conditions, and their magnitudes depended on the stance and the side of perturbation. Accordingly, APAs in lateral muscles increased on the side of perturbation in SS condition, while simultaneous activation of dorsal muscles occurred on the contralateral side. Smaller APAs were seen in lateral muscles in conditions with a wider base of support (NB, RB) and APAs in dorsal muscles were smaller in NB - in comparison to RB - stance. The results of the present study provide new data on the role of lateral, ventral, and dorsal muscles in anticipatory postural control when dealing with lateral perturbations in conditions of postural instability.

  1. The role of anticipatory postural adjustments in compensatory control of posture: 1. Electromyographic analysis.

    Science.gov (United States)

    Santos, Marcio J; Kanekar, Neeta; Aruin, Alexander S

    2010-06-01

    Anticipatory (APAs) and compensatory (CPAs) postural adjustments are the two principal mechanisms that the central nervous system uses to maintain equilibrium while standing. We studied the role of APAs in compensatory postural adjustments. Eight subjects were exposed to external predictable and unpredictable perturbations induced at the shoulder level, while standing with eyes open and closed. Electrical activity of leg and trunk muscles was recorded and analyzed during four epochs representing the time duration typical for anticipatory and compensatory postural control. No anticipatory activity of the trunk and leg muscles was seen in the case of unpredictable perturbations; instead, significant compensatory activation of muscles was observed. When the perturbations were predictable, strong anticipatory activation was seen in all the muscles: such APAs were associated with significantly smaller compensatory activity of muscles and COP displacements after the perturbations. The outcome of the study highlights the importance of APAs in control of posture and points out the existence of a relationship between the anticipatory and the compensatory components of postural control. It also suggests a possibility to enhance balance control by improving the APAs responses during external perturbations.

  2. Effects of airborne-particle abrasion, sodium hydroxide anodization, and electrical discharge machining on porcelain adherence to cast commercially pure titanium.

    Science.gov (United States)

    Acar, Asli; Inan, Ozgür; Halkaci, Selçuk

    2007-07-01

    The aim of this study was to determine the effect of airborne-particle abrasion (APA), sodium hydroxide anodization (SHA), and electrical discharge machining (EDM) on cast titanium surfaces and titanium-porcelain adhesion. Ninety titanium specimens were cast with pure titanium and the alpha-case layer was removed. Specimens were randomly divided into three groups. Ten specimens from each group were subjected to APA. SHA was applied to the second subgroups, and the remaining specimens were subjected to the EDM. For the control group, 10 specimens were cast using NiCr alloy and subjected to only APA. Surfaces were examined by using scanning electron microscope and a surface profilometer. Three titanium porcelains were fused on the titanium surfaces, whereas NiCr specimens were covered with conventional porcelain. Titanium-porcelain adhesion was characterized by a 3-point bending test. Statistical analysis showed that the porcelain-metal bond strength of the control group was higher than that of the titanium-porcelain system (p < 0.05). There were no significant differences between the bond strengths of titanium groups (p 0.05), except the bond strengths of Noritake Super Porcelain TI-22 groups on which APA and SHA were applied (p < 0.05). SHA and EDM as surface treatment did not improve titanium-porcelain adhesion when compared to APA.

  3. High frequencies of elevated alkaline phosphatase activity and rickets exist in extremely low birth weight infants despite current nutritional support

    Directory of Open Access Journals (Sweden)

    Parker Bruce R

    2009-07-01

    Full Text Available Abstract Background Osteopenia and rickets are common among extremely low birth weight infants (ELBW, Methods We evaluated all ELBW infants admitted to Texas Children's Hospital NICU in 2006 and 2007. Of 211 admissions, we excluded 98 patients who were admitted at >30 days of age or did not survive/stay for >6 weeks. Bone radiographs obtained in 32 infants were reviewed by a radiologist masked to laboratory values. Results In this cohort of 113 infants, P-APA was found to have a significant inverse relationship with BW, gestational age and serum phosphorus. In paired comparisons, P-APA of infants Conclusion Elevation of P-APA >600 IU/L was very common in ELBW infants. BW was significantly inversely related to both P-APA and radiologic rickets. No single value of P-APA was related to radiological findings of rickets. Given the very high risk of osteopenia and rickets among ELBW infants, we recommend consideration of early screening and early mineral supplementation, especially among infants

  4. Acid peptidase activity released from in vitro produced porcine embryos: a candidate marker to predict developmental competence.

    Science.gov (United States)

    Telugu, Bhanu Prakash V L; Spate, Lee; Prather, Randall S; Green, Jonathan A

    2009-04-01

    The ability to efficiently create high quality embryos, competent to produce normal viable offspring in vitro, facilitates diverse technological advancements in animal agriculture and assisted reproduction. Current methods for evaluation of embryos are predominantly based on morphological characteristics which are prone to potential bias of the scorer. Metabolic and genetic markers have also been explored for quality assessment, but they are cost prohibitive or require longer periods of time for evaluation. We hypothesized that secreted enzymes could provide another means of embryo quality assessment. In this report, we provide evidence that medium conditioned by porcine embryos often has proteolytic activity that operates in acidic conditions (acid peptidase activity or APA). The APA could be inhibited by pepstatin A, suggesting that the activity is derived from one or more aspartic peptidases. We also provide evidence that single embryos, incubated for as few as 24 hr, released enough APA that it was possible to measure it accurately at day 5 of culture. We also observed that such activity on day 6 could be positively correlated with advanced developmental stage and embryo quality. In addition, those embryos that were graded identically by morphological evaluations often differed in the amount of APA--with some being significantly higher than the experimental threshold value. Therefore, the APA of embryos might serve as an additional marker for evaluation of embryos.

  5. THE STUDY OF PRODUCTION AND MECHANISM OF ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH CORONARY HEART DISEASE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To assess whether there was strong association between antiphospholipid antibodies(APA) and coronary heart disease(CHD), to study the environmental factors of APA production and APA pathogenic mechanism in patients with CHD.Methods Blood samples from 76 patients with CHD and 30 controls were tested for anticardiolipin antibodies IgG(ACA-IgG),human cytomegalovirus IgG,IgM(HCMV-IgG,IgM) by enzyme-link immunosorbant assay(ELISA) and 6-keto-PGF1a,endothelin(ET) by radioimmunoassay(RIA).Results A total of 27 patients(35.53%) were ACA positive in 76, as compared to 2 of 30(6.67%) healthy individuals, P<0.05. There was no difference in ACA among acute myocardial infarction(AMI,39.13%), old myocardial infarction(OMI,26.53%), unstable angina pectoris(UA,38.40%), P>0.05. The number of ACA positive subjects was higher in HCMV infection patients with CHD than no HCMV infectious patients with CHD. There was no PGI2 and ET level difference between ACA-IgG positive and negative CHD.Conclusion There are strong association between APA and CHD. The HCMV infection may be an environmental factor of APA production in CHD patients with raised ACA. The alteration of PGI2 and ET are not the pathogenic mechanism of ACA in patients with CHD.

  6. 澳大利亚预约定价安排(APA)制度借鉴

    Institute of Scientific and Technical Information of China (English)

    陈挺; 曾进

    2011-01-01

    Advance Pricing Arrangement (APA) system in Australia is comparatively mature, and Australia issued the latest guidance of APA Program on March 17th,2011. On the basis of introducing annual bulletin of APA and the latest guidance of APA in Australia, this paper classifies and summarizes eight items of Australian APA deserving for reference, and meanwhile makes an analysis on the developing orientation of APA system in China.%澳大利亚的预约定价安排(APA)制度比较成熟。2011年3月17日该国颁布了最新的预约定价安排指南。本文在介绍澳大利亚预约定价安排年度报告、最新预约定价安排指南的基础上,对澳大利亚预约定价安排制度中八项值得借鉴的内容作了梳理和归纳,同时,分析了我国预约定价安排制度的发展方向。

  7. Perceptions of ethical problems by forensic psychiatrists.

    Science.gov (United States)

    Weinstock, R

    1989-01-01

    A survey was undertaken of the opinions of two groups of forensic psychiatrists to determine their views regarding forensic ethical issues. Although AAPL has made significant strides for our profession by adopting ethical guidelines, some important issues have not yet been addressed, as revealed by our survey. Included were items heretofore considered too "controversial" for incorporation into guidelines, as well as items from the APA ethical framework. All APA items were evaluated as addressing ethical problems. The majority of respondents also viewed most of the "controversial" items as confronting relevant ethical problems, thereby suggesting their inclusion, in some form, in the profession's guidelines. They also appeared to favor retention of many traditional medical ethical values when functioning as a forensic psychiatrist. Clear selective discrimination existed among differing death penalty facets. Since AAPL at present does not wish to conduct its own ethics hearings, the AAPL guidelines as well as the items supported in this paper's survey would best be translated into a form consistent with the APA framework. In this way, AAPL's guidelines and also the new suggested items could readily be coordinated within the APA framework and could play a role in the APA local district branch enforcement process.

  8. Development of NASA's Accident Precursor Analysis Process Through Application on the Space Shuttle Orbiter

    Science.gov (United States)

    Maggio, Gaspare; Groen, Frank; Hamlin, Teri; Youngblood, Robert

    2010-01-01

    Accident Precursor Analysis (APA) serves as the bridge between existing risk modeling activities, which are often based on historical or generic failure statistics, and system anomalies, which provide crucial information about the failure mechanisms that are actually operative in the system. APA docs more than simply track experience: it systematically evaluates experience, looking for under-appreciated risks that may warrant changes to design or operational practice. This paper presents the pilot application of the NASA APA process to Space Shuttle Orbiter systems. In this effort, the working sessions conducted at Johnson Space Center (JSC) piloted the APA process developed by Information Systems Laboratories (ISL) over the last two years under the auspices of NASA's Office of Safety & Mission Assurance, with the assistance of the Safety & Mission Assurance (S&MA) Shuttle & Exploration Analysis Branch. This process is built around facilitated working sessions involving diverse system experts. One important aspect of this particular APA process is its focus on understanding the physical mechanism responsible for an operational anomaly, followed by evaluation of the risk significance of the observed anomaly as well as consideration of generalizations of the underlying mechanism to other contexts. Model completeness will probably always be an issue, but this process tries to leverage operating experience to the extent possible in order to address completeness issues before a catastrophe occurs.

  9. Auricular Point Acupressure for Chronic Low Back Pain: A Feasibility Study for 1-Week Treatment

    Directory of Open Access Journals (Sweden)

    Chao-Hsing Yeh

    2012-01-01

    Full Text Available Objectives. The objective of this one-group, repeated-measures design was to explore the acceptance of auricular point acupressure (APA to reduce chronic low back pain (CLBP and estimate minimum clinically important differences (MCIDs for pain intensity change. Methods. Subjects received 7-day APA treatment. After appropriate acupoints were identified, vaccaria seeds were carefully taped onto each selected auricular point for 7-day. The Brief Pain Inventory Short Form (BPI was used to collect outcome data. Results. A total of 74 subjects participated in the study. Ten subjects dropped out and the retention rate was 87%. Subjects reported a 46% reduction in BPI worst pain, and over 50% reduction in BPI average pain, overall pain severity and pain interference by the end of study, and 62.5% subjects also reported less pain medication use. The MCIDs for the subscale of BPI ranged from .70 to 1.86 points. The percentage improvement of MCIDs from baseline was between 14.5–24.9%. Discussion. APA appears to be highly acceptable to patients with CLBP. A sham group is needed in order to differentiate the true effects of APA from the possible psychological effects of more frequent visits by the auricular therapist and patients’ expectation of the APA treatment.

  10. The Role of Proprioception in the Sagittal Setting of Anticipatory Postural Adjustments During Gait Initiation

    Directory of Open Access Journals (Sweden)

    Pereira Marcelo P.

    2015-12-01

    Full Text Available Purpose. Previous studies have studied the role of proprioception on the setting of anticipatory postural adjustments (APA during gait initiation. However, these studies did not investigate the role of proprioception in the sagittal APA setting. We aimed to investigate the role of proprioception manipulation to induce APA sagittal adaptations on gait initiation. Methods. Fourteen healthy adults performed gait initiation without, and with, vibration applied before movement onset, and during movement. In addition, the effects of two different vibration frequencies (80 and 120Hz were tested. Vibration was applied bilaterally on the tibialis anterior, rectus femoris and trapezius superior. The first step characteristics, ground reaction forces and CoP behaviour were assessed. Results. Vibration improved gait initiation performance regardless of the moment it was applied. CoP velocity during the initial phase of APA was increased by vibration only when it was applied before movement. When vibration was applied to disturb the movement, no effects on the CoP behaviour were observed. Manipulation of vibration frequency had no effects. Conclusions. Rather than proprioception manipulation, the results suggest that post-vibratory effects and attentional mechanisms were responsible for our results. Taken together, the results show that sagittal APA setting is robust to proprioception manipulation.

  11. RNA regulatory elements and polyadenylation in plants

    Directory of Open Access Journals (Sweden)

    Arthur G. Hunt

    2012-01-01

    Full Text Available Alternative poly(A site choice (also known as alternative polyadenylation, or APA has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generation of transcripts with differing 3’-UTRs (and thus differing potential regulatory potential and of transcripts with differing protein-coding potential. Genome-wide studies of possible APA suggest a linkage with pre-mRNA splicing, and indicate a coincidence of and perhaps cooperation between RNA regulatory elements that affect splicing efficiency and the recognition of novel intronic poly(A sites. These studies also raise the possibility of the existence of a novel class of polyadenylation-related cis elements that are distinct from the well-characterized plant polyadenylation signal. Many potential APA events, however, have not been associated with identifiable cis elements. The present state of the field reveals a broad scope of APA, and also numerous opportunities for research into mechanisms that govern both choice and regulation of poly(A sites in plants.

  12. 抗磷脂综合征与妊娠丢失的研究进展%Research progress in relationship of antiphospholipid syndrome and pregnancy loss

    Institute of Scientific and Technical Information of China (English)

    王艳梅; 凌国灿

    2012-01-01

    自身免疫性疾病或免疫功能异常影响妊娠,在自身免疫疾病中,抗磷脂综合征(APS)占了一定比例.本文就抗磷脂抗体(APA)的形成及APA导致妊娠丢失的作用机制进行阐述,旨为今后APS的临床治疗带来更多的启示.%Autoimmue disease or abnormal immunologic function can affect pregnancy. In autoimmune diseases, the antiphospholipid syndrome (APS) has accounted for a certain proportion. This paper illustrated the formation of antiphospholipid antibody (APA) and the mechanism of pregnancy loss caused by APA. It brings some enlightenment for the future APS treatment.

  13. [Antiphospholipid syndrome diagnosis: an update].

    Science.gov (United States)

    Visseaux, Benoit; Masliah-Planchon, Julien; Fischer, Anne-Marie; Darnige, Luc

    2011-01-01

    The antiphospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in association with the persistent presence of autoantibodies called antiphospholipid antibodies (APAs). APAs are a heterogeneous group of circulating autoantibodies that can be detected either by phospholipid-dependent coagulation test for lupus anticoagulant (LA) or ELISA test for anticardiolipin and anti-β2GPI antibodies. In 2006, the revised criteria for the diagnosis of APS introduce the anti-β2GPI antibodies as a new biological criterion and highlight the necessity to increase the interval between two positive APA test from 6 to 12 weeks. However, despite these updated criteria, the diagnosis of APS remains challenging and we proposed here to make an overview of the latest evolution in the diagnosis of this syndrome.

  14. [Association of the insulin-like growth factor II (IGF2) gene with human cognitive functions].

    Science.gov (United States)

    Alfimova, M V; Lezheĭko, T V; Gritsenko, I K; Golimbet, V E

    2012-08-01

    Active search for candidate genes whose polymorphisms are associated with human cognitive functions has been in progress in the past years. The study focused on the role that the insulin-like growth factor II (IGF2) gene may play in the variation of cognitive processes related to executive functions. The ApaI polymorphism of the IGF2 gene was tested for association with selective attention during visual search, working memory/mental control, and semantic verbal fluency in a group of 182 healthy individuals. The ApaI polymorphism was associated with the general cognitive index and selective attention measure. Carriers of genotype AA displayed higher values of the two parameters than carriers of genotype GG. It was assumed that the ApaI polymorphism of the IGF2 gene influences the human cognitive functions, acting possibly via modulation of the IGF-II level in the central nervous system.

  15. A priori analysis: an application to the estimate of the uncertainty in course grades

    CERN Document Server

    Lippi, G L

    2014-01-01

    The a priori analysis (APA) is discussed as a tool to assess the reliability of grades in standard curricular courses. This unusual, but striking application is presented when teaching the section on data treatment of a Laboratory Course to illustrate the characteristics of the APA and its potential for widespread use, beyond the traditional Physics Curriculum. The conditions necessary for this kind of analysis are discussed, the general framework is set out and a specific example is given to illustrate its various aspects. Students are often struck by this unusual application and are more apt to remember the APA. Instructors may also benefit from some of the gathered information, as discussed in the paper.

  16. Fractionation of the mixture obtained by the enzymatic hydrolysis of penicillin G

    Directory of Open Access Journals (Sweden)

    Cascaval Dan

    2002-01-01

    Full Text Available Using the experimental data on the individual physical and reactive extraction of 6APA with 1,2-dichlororethane, D2EHPA and Amberlite LA-2 together with data on the influence of the pH value of the aqueous phase and the Amberlite LA-2 concentration on the selective separation of 6APA, PG and PAA from a mixture, a process flow sheet for the fractionation of the solution obtained by the enzymatic hydrolysis of PG has been elaborated and applied. Thus, at pH=10, 6APA was selectively separated by four extraction stages, the overall extraction degree being 98.8%. PG was selectively extracted from the raffinate at pH=6 by three extraction stages, adjusting the molar concentration of Amberlite LA-2 to the value of the PG molar concentration for each extraction stage. The antibiotic extraction degree was 99.6%.

  17. Ethical Considerations for Psychologists Taking a Public Stance on Controversial Issues: The Balance Between Personal and Professional Life.

    Science.gov (United States)

    Haeny, Angela M

    2014-07-01

    Previous literature has documented the general issues psychologists often face while balancing their personal and professional lives. The struggle stems from attempting to satisfy the need to maintain a life outside of work while having the professional obligation to follow the American Psychological Association's (APA's) Ethical Principles of Psychologists and Code of Conduct (Ethics Code) to prevent their personal lives from interfering with their professional roles and relationships. The present paper analyzes the subject of psychologists taking a public position on controversial public issues. Although the APA Ethics Code does not restrict how psychologists conduct themselves during their personal time, taking a public stance on a controversial issue could potentially strain professional relationships and inadvertently reflect negatively on the profession. The present paper examines ethical issues that a) should be taken into account before psychologists take a public position on a controversial issue, and b) are in conflict with APA's Ethics Code or current research.

  18. Best kept secrets ... First Coast Systems, Inc. (FCS).

    Science.gov (United States)

    Andrew, W F

    1991-04-01

    The FCS/APaCS system is a viable option for small-to medium-size hospitals (up to 400 beds). The table-driven system takes full advantage of IBM AS/400 computer architecture. A comprehensive application set, provided in an integrated database environment, is adaptable to multi-facility environments. Price/performance appears to be competitive. Commitment to IBM AS/400 environment assures cost-effective hardware platforms backed by IBM support and resources. As an IBM Health Industry Business Partner, FCS (and its clients) benefits from IBM's well-known commitment to quality and service. Corporate emphasis on user involvement and satisfaction, along with a commitment to quality and service for the APaCS systems, assures clients of "leading edge" capabilities in this evolutionary healthcare delivery environment. FCS/APaCS will be a strong contender in selected marketing environments.

  19. Translator's preface.

    Science.gov (United States)

    Lamiell, James T

    2013-08-01

    Presents a preface from James T. Lamiell, who translates Wilhelm Wundt's Psychology's Struggle for Existence (Die Psychologie im Kampf ums Dasein), in which Wundt advised against the impending divorce of psychology from philosophy, into English. Lamiell comments that more than a decade into the 21st century, it appears that very few psychologists have any interest at all in work at the interface of psychology and philosophy. He notes that one clear indication of this is that the Society for Theoretical and Philosophical Psychology, which is Division 24 of the American Psychological Association (APA), remains one of the smallest of the APA's nearly 60 divisions. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  20. 微囊化人血管抑素基因工程细胞对人脐静脉内皮细胞增殖的影响%Effect of Microencapsulated Human Angiostatin Gene Engineered Cell on the Proliferation of Human Umbilical Vein Endothelial Cell

    Institute of Scientific and Technical Information of China (English)

    罗芸; 薛毅珑; 赵卉

    2012-01-01

    Objective To study the effect of microencapsulated human angiostatin gene engineered cell on the proliferation of human umbilical vein endothelial cell Huecv304. Methods Alginate - polylysine -alginate (APA)was used to encapsulate 293 cells expressing human angioslain (APA - hAS/293) or empty vector (APA -0/293). Microencapsulated APA - hAS/293 or APA -0/293 cells were co - cultured with Huecv304 in different cell concentration. After 0, 24, 48 and 72h, the proliferation of Huecv304 was measured with MTT assay. Results Microencapsulated APA - hAS/293 inhibited the proliferation of cocultured Huecv304 cells ( P < 0. 01 ) in a dose -dependent manner. While microencapsulated APA - 0/293 didn't inhibit the proliferation of Huecv304 cells in co - culture. Conclusion The secretion of gene engineered cells expressing human angiostatin could pass through the membrane of microencapsule and inhibit the proliferation of human umbilical vein endothelial cells.%目的 了解海藻酸钠-多聚赖氨酸-海藻酸钠(alginate - polylysine - alginate,APA)微囊化人血管抑素基因工程细胞对人脐静脉内皮细胞(Huecv304)增殖的影响.方法 采用APA制备微囊包裹的表达人血管抑素(human angiostatin,hAS)的基因工程细胞(APA - hAS/293细胞微囊)或空载体转染的基因工程细胞(APA - 0/293细胞微囊).分别将上述两种细胞微囊以不同浓度与人脐静脉内皮细胞Huecv304细胞共培养,于培养0、24、48及72h时,以MTT法测定Huecv304细胞的增殖情况.结果 APA - hAS/293细胞微囊对共培养的Huecv304细胞的增殖具有明显的抑制作用(P<0.01),且具有良好的量效关系.而对照组APA - 0/293细胞微囊对Huecv304细胞的增殖无明显抑制作用.结论 体外培养的表达人血管抑素基因的工程细胞的分泌物可以通过微囊膜并对人脐静脉内皮细胞的增殖产生显著的抑制效应.