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Sample records for apa

  1. Demystifying APA style.

    Science.gov (United States)

    Cuddy, Claudia M

    2002-01-01

    Many nursing schools and health care journals have adopted the Publication Manual of the American Psychological Association (APA stylebook) as their guide to achieve uniformity and consistency in manuscript preparation as well as in usage and writing style. Published in 2001, the fifth edition of the APA stylebook contains 440 pages and can overwhelm someone who tries to use it for the first time. This article delineates main points in the areas of manuscript preparation, reference lists, in-text citations, and style choices. PMID:12432698

  2. APA Educational Psychology Handbook

    Science.gov (United States)

    Harris, Karen R., Ed.; Graham, Steve, Ed.; Urdan, Tim, Ed.

    2011-01-01

    The "APA Educational Psychology Handbook" reflects the broad nature of the field today, with state-of-the-science reviews of the diverse critical theories driving research and practice; in-depth investigation of the range of individual differences and cultural/contextual factors that affect student achievement, motivation, and beliefs; and close…

  3. Guide to APA-Based Models

    Science.gov (United States)

    Robins, Robert E.; Delisi, Donald P.

    2008-01-01

    In Robins and Delisi (2008), a linear decay model, a new IGE model by Sarpkaya (2006), and a series of APA-Based models were scored using data from three airports. This report is a guide to the APA-based models.

  4. APA's Role in Fostering Good Testing Practices.

    Science.gov (United States)

    Camara, Wayne J.

    Psychological testing has played a major role in the American Psychological Association (APA) because testing and assessment are important aspects of what psychologists do; tests assist psychologists in diagnosis and treatment. From its earliest years, APA has had one or more committees concerned with testing. The present Committee on…

  5. Sport and APA: proces of possible diffusion

    OpenAIRE

    Hana Válková

    2011-01-01

    Relation between Adapted Physical Activity (APA) are described in the article. Recent sport professions as so as professions related to sports are formulated. "Coach" profession is defined with more details, the term "sport of persons with disability" is explained, too. On the bases of personal experience the APA domain which every coach can be touched are presented. Events which recent coaches, sports clubs in Czech Republic participated in are added. The basic questions of EUSAPA project ar...

  6. Sport and APA: proces of possible diffusion

    Directory of Open Access Journals (Sweden)

    Hana Válková

    2011-03-01

    Full Text Available Relation between Adapted Physical Activity (APA are described in the article. Recent sport professions as so as professions related to sports are formulated. "Coach" profession is defined with more details, the term "sport of persons with disability" is explained, too. On the bases of personal experience the APA domain which every coach can be touched are presented. Events which recent coaches, sports clubs in Czech Republic participated in are added. The basic questions of EUSAPA project are answered: regular sport and APA are blended together. Diffusion of sport and APA can become good platform for inclusion in life span context. Coaches should be informed about basic principles of APA according the level of connection (humanitarian domain - coaches in sports of disabled, the type of sport (relation to general sport and performance level (recreation - top competitive. The topic APA should be included on adequate level in education courses of coaches. The practice in sport activities of people with disability has to be involved.

  7. Resolving a Conflict between APA Learning Goals and APA Ethical Principles

    Science.gov (United States)

    Corty, Eric W.

    2008-01-01

    Although American Psychological Association (APA) Ethical Standards make it clear that instructors cannot require students to disclose personal information in class-related activities, an APA learning goal for undergraduate psychology students is that they reflect on their experiences to develop insight into their behavior and mental processes.…

  8. Who Cares about APA Policy and Does it Have an Impact? 2006 Annual Report of the APA Policy and Planning Board

    Science.gov (United States)

    American Psychologist, 2007

    2007-01-01

    What constitutes American Psychological Association (APA) policy? How does it affect the everyday and professional lives of APA members? How personally aware are psychologists of APA policies? In this report, the APA explores these questions and provide some intriguing findings on the fate of policies developed through the APA's complicated and…

  9. The Ethics of APA's Goldwater Rule.

    Science.gov (United States)

    Kroll, Jerome; Pouncey, Claire

    2016-06-01

    Section 7.3 of the code of ethics of the American Psychiatric Association (APA) cautions psychiatrists against making public statements about public figures whom they have not formally evaluated. The APA's concern is to safeguard the public perception of psychiatry as a scientific and credible profession. The ethic is that diagnostic terminology and theory should not be used for speculative or ad hominem attacks that promote the interests of the individual physician or for political and ideological causes. However, the Goldwater Rule presents conflicting problems. These include the right to speak one's conscience regarding concerns about the psychological stability of high office holders and competing considerations regarding one's role as a private citizen versus that as a professional figure. Furthermore, the APA's proscription on diagnosis without formal interview can be questioned, since third-party payers, expert witnesses in law cases, and historical psychobiographers make diagnoses without conducting formal interviews. Some third-party assessments are reckless, but do not negate legitimate reasons for providing thoughtful education to the public and voicing psychiatric concerns as acts of conscience. We conclude that the Goldwater Rule was an excessive organizational response to what was clearly an inflammatory and embarrassing moment for American psychiatry. PMID:27236179

  10. The APA Style Converter: a Web-based interface for converting articles to APA style for publication.

    Science.gov (United States)

    Li, Ping; Cunningham, Krystal

    2005-05-01

    The APA Style Converter is a Web-based tool with which authors may prepare their articles in APA style according to the APA Publication Manual (5th ed.). The Converter provides a user-friendly interface that allows authors to copy and paste text and upload figures through the Web, and it automatically converts all texts, references, and figures to a structured article in APA style. The output is saved in PDF or RTF format, ready for either electronic submission or hardcopy printing. PMID:16171194

  11. APA, Meet Google: Graduate Students' Approaches to Learning Citation Style

    Science.gov (United States)

    Van Note Chism, Nancy; Weerakoon, Shrinika

    2012-01-01

    Inspired by Perkins' Theories of Difficulty concept, this exploratory study examined the learning patterns of graduate students as they grappled with using the style sheet of the American Psychological Association (APA). The researchers employed task performance analysis of three APA formatting tasks, interviews, and observation during a "think…

  12. Citar e referenciar : APA 6ª ed.

    OpenAIRE

    Marcos, Isabel Marques

    2016-01-01

    A elaboração correta dos trabalhos científicos pressupõe o respeito por um conjunto de princípios normativos de citação e referenciação bibliográfica que salvaguardam os autores das criações intelectuais do uso indevido das mesmas. Partindo de três conceitos: citação, referência bibliográfica e lista de referências apresentam-se as normas da APA 6ª ed. nos seus elementos essenciais. Estas normas, da área da informação e documentação, definem regras para a normalização das referências bibliogr...

  13. APA with Evolving Order and Variable Regularization for Echo Cancellation

    Directory of Open Access Journals (Sweden)

    Chang-Peng Ji

    2014-01-01

    Full Text Available Recently APA has become one of most popular algorithms in application of Acoustic Echo Cancellation. Because of the contradictory factors of convergence rate and steady-state misalignment, a new algorithm by the behavior of associating variable regularization and evolving order has been proposed in this paper. Despite of the conventional assumption that the a posteriori error is zero, we take the statistical characteristic of the noise into consideration during the adaptation process. Exact and approximate formulations for the optimal regularization factor are derived. Numerical simulation results show that the proposed algorithm improves the performance of the APA in terms of its faster convergence rate and lower steady-state misalignment compared to existing variable regularization APA and evolving order APA, respectively. Meanwhile it can be seen that near-end speech signal has been restored more effectively

  14. Instructional Strategies to Improve College Students' APA Style Writing

    Science.gov (United States)

    Mandernach, B. Jean; Zafonte, Maria; Taylor, Caroline

    2016-01-01

    The purpose of this study was to identify areas of APA formatting that college instructors view as most problematic in student writing. Using a Likert-style survey, the greatest areas of reported concern were problems with documentation, specifically, citations, references, and quoting; of lesser concern were various style and formatting errors in…

  15. 76 FR 37880 - Hours of Service (HOS) of Drivers; Granting of Exemption; American Pyrotechnics Association (APA)

    Science.gov (United States)

    2011-06-28

    .... In 2009, FMCSA granted the same limited exemption to 14 new APA-member motor carriers (74 FR 29266, June 19, 2009) and renewed 61exemptions of APA-member motor carriers (74 FR 29264, June 19, 2009) for..., FMCSA published a notice in the Federal Register (76 FR 30232) announcing APA's application...

  16. Gregory Daniel Webster: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2006-11-01

    Presents a citation for Gregory Daniel Webster, who received the Psi Chi/APA Edwin B. Newman Graduate Research Award "for an outstanding research paper whose findings report that APA journal articles became shorter in length after the year 2000." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115835

  17. PlantAPA: A Portal for Visualization and Analysis of Alternative Polyadenylation in Plants

    Science.gov (United States)

    Wu, Xiaohui; Zhang, Yumin; Li, Qingshun Q.

    2016-01-01

    Alternative polyadenylation (APA) is an important layer of gene regulation that produces mRNAs that have different 3′ ends and/or encode diverse protein isoforms. Up to 70% of annotated genes in plants undergo APA. Increasing numbers of poly(A) sites collected in various plant species demand new methods and tools to access and mine these data. We have created an open-access web service called PlantAPA (http://bmi.xmu.edu.cn/plantapa) to visualize and analyze genome-wide poly(A) sites in plants. PlantAPA provides various interactive and dynamic graphics and seamlessly integrates a genome browser that can profile heterogeneous cleavage sites and quantify expression patterns of poly(A) sites across different conditions. Particularly, through PlantAPA, users can analyze poly(A) sites in extended 3′ UTR regions, intergenic regions, and ambiguous regions owing to alternative transcription or RNA processing. In addition, it also provides tools for analyzing poly(A) site selections, 3′ UTR lengthening or shortening, non-canonical APA site switching, and differential gene expression between conditions, making it more powerful for the study of APA-mediated gene expression regulation. More importantly, PlantAPA offers a bioinformatics pipeline that allows users to upload their own short reads or ESTs for poly(A) site extraction, enabling users to further explore poly(A) site selection using stored PlantAPA poly(A) sites together with their own poly(A) site datasets. To date, PlantAPA hosts the largest database of APA sites in plants, including Oryza sativa, Arabidopsis thaliana, Medicago truncatula, and Chlamydomonas reinhardtii. As a user-friendly web service, PlantAPA will be a valuable addition to the community of biologists studying APA mechanisms and gene expression regulation in plants. PMID:27446120

  18. A Better Affine Projection Algorithm (APA) Using Adaptive Gain (AG)%自适应增益APA-AG算法的研究

    Institute of Scientific and Technical Information of China (English)

    智永锋; 范蟠果; 张骏; 邓正宏; 张怡

    2011-01-01

    为了提高自适应滤波器的收敛性和跟踪性,提出了一种自适应增益APA-AG算法.通过分析估计输出误差信号,获得了参数迭代步长的一个特定值估计,以实现集平均代价函数最小化.仿真结果表明,相比较于传统的APA算法,文中研究的APA-AG算法具有更快的收敛速率和更好的跟踪特性.%Aim. To improve the convergence rate and tracking performance of an adaptive filter, especially for the highly colored input signals, Refs. 3 and 4 adopt the APA algorithm. However, its gain does not change, and thus its convergence is not as rapid as is possible, in our opinion, with adaptive gain. We explain mathematically in sections 1, 2 and 3 of the full paper our APA-AG algorithm and discuss how to minimize the ensemble-average cost function by analyzing the estimated output-error. The core of section 2, which is entitled the estimated output-error analysis of the APA algorithm, is that we derive eq. (23). The core of section 3, which is entitled APA-AG algorithm, is that, to minimize the ensemble-average cost function, we obtain the estimated iterated step-sizes of our APA-AG algorithm; the needed equations are eqs. (23), (3c), (28), (27), (26) and (30). Section 4 presents two numerical examples to simulate our APA-AG algorithm; the simulation results, shown in Figs. 1 and 2,and their analysis indicate preliminarily that our APA-AG algorithm has faster convergence rate and better tracking performance compared with the conventional APA algorithm.

  19. Cloning of the Aspergillus parasiticus apa-2 gene associated with the regulation of aflatoxin biosynthesis.

    OpenAIRE

    Chang, P K; Cary, J W; D. Bhatnagar; Cleveland, T E; Bennett, J W; Linz, J E; Woloshuk, C P; Payne, G A

    1993-01-01

    An Aspergillus parasiticus gene, designated apa-2, was identified as a regulatory gene associated with aflatoxin biosynthesis. The apa-2 gene was cloned on the basis of overproduction of pathway intermediates following transformation of fungal strains with cosmid DNA containing the aflatoxin biosynthetic genes nor-1 and ver-1. Transformation of an O-methylsterigmatocystin-accumulating strain, A. parasiticus SRRC 2043, with a 5.5-kb HindIII-XbaI DNA fragment containing apa-2 resulted in overpr...

  20. Protein Crystallization by Anodic Porous Alumina (APA) Template: The Example of Hen Egg White Lysozyme (HEWL)

    OpenAIRE

    Eugenia Pechkova; Nicola Luigi Bragazzi; Claudio Nicolini

    2015-01-01

    In this communication, we report anodic porous alumina (APA) template induced crystallization. The APA nanotemplate was prepared on the glass substrate for the hen egg white lysozyme (HEWL) crystal growth. The changes in the lysozyme crystals morphology, namely in the a/c axis ratio, were observed in the crystal grown by APA nanotemplate, but not in the crystal obtained with classical hanging drop vapor diffusion method, under the same experimental conditions. The comparison of the diffractio...

  1. Guide för referenshantering : APA-manual inom Barn- och ungdomsvetenskap (BUVA)

    OpenAIRE

    Engdahl, Ingrid

    2014-01-01

    Denna guide behandlar först hur du enligt APA refererar i löpande text och därefter hur man skriver en referenslista. För en komplett guide till APA Style hänvisas till Publication Manual of the American Psychological Association (American Psychological Association, 2010) eller till hemsidan http://www.apastyle.org, där det finns tydlig introduktion i ljud och bild till APA Style.

  2. 抗磷脂抗体(APA)对人和动物生殖的影响%The Effect of Antiphospholipid Antibodies (APA) on Reproduction of Human and Animals

    Institute of Scientific and Technical Information of China (English)

    赫晓燕; 范瑞文

    2003-01-01

    有关研究表明,动物许多自身免疫性疾病或免疫功能异常能够影响妊娠,与自身抗体--抗磷脂抗体( APA)有关.文章就抗磷脂抗体( APA)的种类、性质、作用机制、对人和动物生殖的影响进行了综述.

  3. 77 FR 38378 - Hours of Service (HOS) of Drivers; Revision of Exemption; American Pyrotechnics Association (APA)

    Science.gov (United States)

    2012-06-27

    ... carriers and added 9 new APA-member carriers (76 FR 37876 and 76 FR 37880, June 28, 2011) for their... published on June 28, 2011 (76 FR 37876-37882). Issued on: June 21, 2012. Larry W. Minor, Associate... Exemption; American Pyrotechnics Association (APA) AGENCY: Federal Motor Carrier Safety...

  4. 76 FR 30232 - Hours of Service (HOS) of Drivers; Application of American Pyrotechnics Association (APA) for...

    Science.gov (United States)

    2011-05-24

    ... 14 new APA- member motor carriers (74 FR 29266, June 10, 2009) and renewed 61 exemptions of APA... review DOT's complete Privacy Act Statement in the Federal Register published on January, 17, 2008 (73 FR... FR 29264, June 19, 2009). The renewal would cover 54 of the 61 member motor carriers listed in...

  5. The Impact of APA and AERA Guidelines on Effect Size Reporting

    Science.gov (United States)

    Peng, Chao-Ying Joanne; Chen, Li-Ting; Chiang, Hsu-Min; Chiang, Yi-Chen

    2013-01-01

    Given the long history of effect size (ES) indices (Olejnik and Algina, "Contemporary Educational Psychology," 25, 241-286 2000) and various attempts by APA and AERA to encourage the reporting and interpretation of ES to supplement findings from inferential statistical analyses, it is essential to document the impact of APA and AERA standards on…

  6. 76 FR 37876 - Hours of Service (HOS) of Drivers; Renewal of American Pyrotechnics Association (APA) Exemption...

    Science.gov (United States)

    2011-06-28

    ..., FMCSA granted a limited exemption to 14 new APA-member motor carriers (74 FR 29266, June 19, 2009) and renewed 61exemptions of APA-member motor carriers (74 FR 29264, June 19, 2009) for their CMV... published in the Federal Register on January 17, 2008 (73 FR 3316) or you may visit...

  7. Effect of Mixed Solvents and Additives on the Habit Modification of 6-APA Crystals

    Institute of Scientific and Technical Information of China (English)

    GONG Junbo; WANG Jingkang; WEI Hongyuan

    2005-01-01

    6-aminopenicillanic acid (6-APA) crystals obtained under different physical and chemical conditions of the solutions may present different habits. The habits of diamond-shaped plates are desirable compared with other habits of 6-APA crystals. To obtain ideal 6-APA crystals, the effects of the mixed solvents and additives on 6-APA crystal habits were investigated. Ethanol or acetone was used as the organic solvent, and impurities existing in the 6-APA purification process were used as the additives. 6-APA growth habits were changed when the concentrations of ethanol, acetone or phenyl acetic acid were increased to exceed their critical concentration. The observed results show that the dominant face on 6-APA crystals was identified to be {020}, but the overall habit was controlled by the relative growth rates of the {101} and {002} faces. Crystal growth rates and habits can be appreciably changed by specific adsorption of additives on crystal faces.In some cases solvent molecules can act in a similar way and may be regarded as bulk additives. The effects of additives and organic solvents on 6-APA crystal habits were the results of adsorption effect, which fitted the experimental results quite well.

  8. Mona M. Amer: APA/APAGS award for distinguished graduate student in professional psychology.

    Science.gov (United States)

    2006-11-01

    Presents the citation of Mona M. Amer, who received the APA/APAGS Award for Distinguished Graduate Student in Professional Psychology "for her outstanding and innovative leadership in addressing the mental health needs of Muslim and Arab Americans." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115845

  9. Teaching Scientific Writing: Measuring Student Learning in an Intensive APA Skills Course

    Science.gov (United States)

    Luttrell, Vickie R.; Bufkin, Jana L.; Eastman, Valerie J.; Miller, Robin

    2010-01-01

    The "Publication Manual of the American Psychological Association" (American Psychological Association [APA], 2010) provides a widely utilized template for preparing research reports in the behavioral sciences. Because learning APA style is integral to disciplinary socialization, our department recently implemented a 1-hr course in scientific…

  10. Nonparametric VSS-APA based on precise background noise power estimate

    Institute of Scientific and Technical Information of China (English)

    昊翔; 赖晓翰; 陈隆道; 蔡忠法

    2015-01-01

    The adaptive algorithm used for echo cancellation (EC) system needs to provide 1) low misadjustment and 2) high convergence rate. The affine projection algorithm (APA) is a better alternative than normalized least mean square (NLMS) algorithm in EC applications where the input signal is highly correlated. Since the APA with a constant step-size has to make compromise between the performance criteria 1) and 2), a variable step-size APA (VSS-APA) provides a more reliable solution. A nonparametric VSS-APA (NPVSS-APA) is proposed by recovering the background noise within the error signal instead of cancelling the a posteriori errors. The most problematic term of its variable step-size formula is the value of background noise power (BNP). The power difference between the desired signal and output signal, which equals the power of error signal statistically, has been considered the BNP estimate in a rough manner. Considering that the error signal consists of background noise and misalignment noise, a precise BNP estimate is achieved by multiplying the rough estimate with a corrective factor. After the analysis on the power ratio of misalignment noise to background noise of APA, the corrective factor is formulated depending on the projection order and the latest value of variable step-size. The new algorithm which does not require any a priori knowledge of EC environment has the advantage of easier controllability in practical application. The simulation results in the EC context indicate the accuracy of the proposed BNP estimate and the more effective behavior of the proposed algorithm compared with other versions of APA class.

  11. Linkage disequilibrium at the APA insecticidal seed protein locus of common bean (Phaseolus vulgaris L.

    Directory of Open Access Journals (Sweden)

    Buendía Héctor F

    2010-04-01

    Full Text Available Abstract Background An interesting seed protein family with a role in preventing insect herbivory is the multi-gene, APA family encoding the α-amylase inhibitor, phytohemagglutinin and arcelin proteins of common bean (Phaseolus vulgaris. Variability for this gene family exists and has been exploited to breed for insect resistance. For example, the arcelin locus has been successfully transferred from wild to cultivated common bean genotypes to provide resistance against the bruchid species Zabrotes subfasciatus although the process has been hampered by a lack of genetic tools for and understanding about the locus. In this study, we analyzed linkage disequilibrium (LD between microsatellite markers at the APA locus and bruchid resistance in a germplasm survey of 105 resistant and susceptible genotypes and compared this with LD in other parts of the genome. Results Microsatellite allele diversity was found to vary with each of the eight APA-linked markers analyzed, and two markers within the APA locus were found to be diagnostic for bruchid resistance or susceptibility and for the different arcelin alleles inherited from the wild accessions. Arc1 was found to provide higher levels of resistance than Arc5 and the markers in the APA locus were highly associated with resistance showing that introgression of this gene-family from wild beans provides resistance in cultivated beans. LD around the APA locus was found to be intermediate compared to other regions of the genome and the highest LD was found within the APA locus itself for example between the markers PV-atct001 and PV-ag004. Conclusions We found the APA locus to be an important genetic determinant of bruchid resistance and also found that LD existed mostly within the APA locus but not beyond it. Moderate LD was also found for some other regions of the genome perhaps related to domestication genes. The LD pattern may reflect the introgression of arcelin from the wild into the cultivated

  12. AB203. The mutational landscapes of adrenal cortex aldosterone-producing adenoma (APA) diversified between different populations

    OpenAIRE

    Wu, Song; Huang, Peide; Zhang, Meng

    2015-01-01

    Objective The genetic determinants of aldosterone-producing adrenal adenoma (APA), one of the most common causes of secondary hypertension, had been studied intensively in European patients but its mutational landscapes in Asian populations remained unclear. We aim to further understand the genetic determinants of APA in East Asian patients. Methods We perform Whole-exome sequencing and comprehensive data analyses in tumors and matched normal tissues from 22 Chinese APA patients. Results Nota...

  13. Adam M. Reid: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2015-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. One of the 2015 award winners is Adam M. Reid, who received this award "for his community service, in which he has integrated the highest standards of professional psychological clinical practice and science." Adam's award citation, biography, and a selected bibliography are presented here. PMID:26618976

  14. Research Productivity and Scholarly Impact of APA-Accredited School Psychology Programs: 2005-2009

    Science.gov (United States)

    Kranzler, John H.; Grapin, Sally L.; Daley, Matt L.

    2011-01-01

    This study examined the research productivity and scholarly impact of faculty in APA-accredited school psychology programs using data in the PsycINFO database from 2005 to 2009. We ranked doctoral programs on the basis of authorship credit, number of publications, and number of citations. In addition, we examined the primary publication outlets of…

  15. Cynthia J. Najdowski: Psi Chi/APA Edwin B. Newman Graduate Research Award

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents a short biography of the winner of the American Psychological Association's Psi Chi/APA Edwin B. Newman Graduate Research Award. The 2012 winner is Cynthia J. Najdowski for an outstanding research paper that examines how jurors' judgments are influenced by a juvenile defendant's confession and status as intellectually disabled. Through…

  16. Internship Attainment and Program Policies: Trends in APA-Accredited School Psychology Programs

    Science.gov (United States)

    Perfect, Michelle M.; Thompson, Miriam E.; Mahoney, Emery

    2015-01-01

    Completion of an internship that is accredited by the American Psychological Association (APA) is considered to be to the "gold standard" for health service psychology training programs. The Association of Psychology Postdoctoral and Internship Centers (APPIC) facilitates a Match process between participating applicants and internship…

  17. Scholarly Productivity and Impact of School Psychology Faculty in APA-Accredited Programs

    Science.gov (United States)

    Grapin, Sally L.; Kranzler, John H.; Daley, Matt L.

    2013-01-01

    The primary objective of this study was to conduct a normative assessment of the research productivity and scholarly impact of tenured and tenure-track faculty in school psychology programs accredited by the American Psychological Association (APA). Using the PsycINFO database, productivity and impact were examined for the field as a whole and by…

  18. A Survey of Rorschach Teaching in APA-Approved Clinical Graduate Programs

    Science.gov (United States)

    Del Gaudio, Andrew C.; Ritzler, Barry A.

    1976-01-01

    This survey of APA-approved doctoral programs in clinical psychology provides a status assessment of the Rorschach technique. Eighty-one percent emphasized the technique; a quarter offered the course for a full year; respondents with more experience rated the technique higher; and its was rated highly as a clinical tool and teaching aid, but low…

  19. APA Reporting Standards in Quantitative Research Dissertations from an Online EdD Program

    Science.gov (United States)

    Salgado, Griselle

    2013-01-01

    This study was an investigation of the reporting practices in dissertations with quantitative research designs produced by students enrolled in an online Doctor of Education (EdD) program, one that follows the American Psychological Association (APA) standards for reporting research. Limited, empirical information exists about the competencies in…

  20. Teaching Intelligence Testing in APA-Accredited Programs: A National Survey.

    Science.gov (United States)

    Cody, M. Schelle; Prieto, Loreto R.

    2000-01-01

    Provides information on how intelligence testing courses are currently taught in a sample of American Psychological Association (APA)-accredited clinical and school psychology programs from across the United States and Canada. Discusses limitations of the study and teaching strategies to improve students' test administration skills. (CMK)

  1. APA's Learning Objectives for Research Methods and Statistics in Practice: A Multimethod Analysis

    Science.gov (United States)

    Tomcho, Thomas J.; Rice, Diana; Foels, Rob; Folmsbee, Leah; Vladescu, Jason; Lissman, Rachel; Matulewicz, Ryan; Bopp, Kara

    2009-01-01

    Research methods and statistics courses constitute a core undergraduate psychology requirement. We analyzed course syllabi and faculty self-reported coverage of both research methods and statistics course learning objectives to assess the concordance with APA's learning objectives (American Psychological Association, 2007). We obtained a sample of…

  2. Complementing the Latest APA Definition of Hypnosis: Sensory-Motor and Vascular Peculiarities Involved in Hypnotizability.

    Science.gov (United States)

    Santarcangelo, Enrica L; Scattina, Eliana

    2016-01-01

    The aim of this article is to complement the recently revised American Psychological Association (APA) definition of hypnotizability. It (a) lists a few differences in sensorimotor integration between subjects with high (highs) and low (lows) hypnotizability scores in the ordinary state of consciousness and in the absence of suggestions, (b) proposes that hypnotizability-related cerebellar peculiarities may account for them, PMID:27267676

  3. APA-style human milk fat analogue from silkworm pupae oil: Enzymatic production and improving storage stability using alkyl caffeates

    OpenAIRE

    Xi Liu; Xudong Wang; Na Pang; Weijie Zhu; Xingyu Zhao; Fangqin Wang; Fuan Wu; Jun Wang

    2015-01-01

    Silkworm pupae oil derived from reeling waste is a rich source of α-linolenic acid (ALA), which has multipal applications. ALAs were added in sn-1, 3 positions in a triacylglycerol (TAG) to produce an APA-human milk fat analogues (APA-HMFAs, A: α-linolenic acid, P: palmitic acid). The optimum condition is that tripalmitin to free fatty acids of 1:12 (mole ratio) at 65 °C for 48 h using lipase Lipozyme RM IM. Results show that, the major TAG species that comprised APA-HMFAs were rich in ALA an...

  4. Allie Abrahamson: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2014-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. This year there are joint recipients of the award, Allie Abrahamson and Rebeccah A. Bernard. Their vision, creativity, courage, and dedication led them to create the Human Rights Forum at Chestnut Hill College to promote human rights education, awareness, and community service opportunities for doctoral students. Allie Abrahamson's award citation, biography, and a selected bibliography are presented here. PMID:25486169

  5. Rebeccah A. Bernard: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

    Science.gov (United States)

    2014-11-01

    The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. A qualified candidate must demonstrate exemplary performance in working with an underserved population in an applied setting or have developed an innovative method for delivering health services to an underserved population. This year there are joint recipients of the award, Allie Abrahamson and Rebeccah A. Bernard. Their vision, creativity, courage, and dedication led them to create the Human Rights Forum at Chestnut Hill College to promote human rights education, awareness, and community service opportunities for doctoral students. Rebeccah A. Bernard's award citation, biography, and a selected bibliography are presented here. PMID:25486170

  6. Induction of Extracellular Matrix-Remodeling Genes by the Senescence-Associated Protein APA-1

    OpenAIRE

    Benanti, Jennifer A.; Williams, Dawnnica K.; Robinson, Kristin L; Ozer, Harvey L.; Galloway, Denise A.

    2002-01-01

    Human fibroblasts undergo cellular senescence after a finite number of divisions, in response to the erosion of telomeres. In addition to being terminally arrested in the cell cycle, senescent fibroblasts express genes that are normally induced upon wounding, including genes that remodel the extracellular matrix. We have identified the novel zinc finger protein APA-1, whose expression increased in senescent human fibroblasts independent of telomere shortening. Extended passage, telomerase-imm...

  7. Synthesis and properties of ApA analogues with shortened phosphonate internucleotide linkage

    Czech Academy of Sciences Publication Activity Database

    Králíková, Šárka; Buděšínský, Miloš; Barvík, I.; Masojídková, Milena; Točík, Zdeněk; Rosenberg, Ivan

    2011-01-01

    Roč. 30, 7/9 (2011), s. 524-543. ISSN 1525-7770 R&D Projects: GA ČR GA202/09/0193; GA AV ČR KAN200520801; GA MŠk(CZ) LC06061 Institutional research plan: CEZ:AV0Z40550506 Keywords : alpha-hydroxy-phosphonate linkage * ApA analogues * phosphonate internucleotide bond * NMR conformational study Subject RIV: CC - Organic Chemistry Impact factor: 0.899, year: 2011

  8. Preparation of 6-APA by Enzymatic Bioconversion in an Emulsion Liquid Membrane Reactor

    Institute of Scientific and Technical Information of China (English)

    陆强; 胡鸣; 熊丹柳; 邓修

    2001-01-01

    Production of 6-aminopenicillanic acid (6-APA) by hydrolysis using penicillin acylase (PA) was studied as a model of an enzymatic emulsion liquid membrane (ELM) process. The loss of PA activity was examined for various membrane compositions (organic solvent, surfactant, carrier). The effects of some experimental variables on the stability of emulsion were investigated. It was found that the choice of organic solvent greatly affected tilestability of the emulsion. Increasing the concentration of the carrier in the membrane phase increases the transfer rate of substrate and products but also has a destabilizing effect on the emulsion. The recovery of 6-APA obtained by a di-carrier system (N263-N1923) was much higher than those when either of the di-carriers was used separately.The whole process was controlled both by the enzymatic reaction rate and by the transfer rate of the substrate and the products, however, the ratio of them could be changed by varying the composition of the system. For an optimum condition, it was obtained that the recovery ratio of 6-APA was over 80% and the conversion of benzyl penicillin (PG) was up to 90% in the external phase after 30 minutes. Meanwhile, the breakage percentage of the emulsion was less than 2%.

  9. Continuous Production of 6-amino Penicillanic Acid (6-APA) by Agarose Immobilized Penicillin Acylase in a Packed Column Reactor

    OpenAIRE

    Banerjee, S.; Debnath, M.

    2007-01-01

    Penicillin acylase, an industrially important biocatalyst catalyzes the conversion of penicillins to 6-amino penicillanic acid (6-APA) which is the main precursor for the production of semi-synthetic -lactam antibiotics. The present work involves the continuous production of 6-APA in a packed column reactor by using agarose immobilized penicillin acylase as a block polymer. The strain Escherichia coli ATCC 11105 was used as enzyme source and penicillin G as substrate. The acidic nature of 6-A...

  10. G Allele of the IGF2 ApaI Polymorphism Is Associated With Judo Status.

    Science.gov (United States)

    Itaka, Toshio; Agemizu, Kenichiro; Aruga, Seiji; Machida, Shuichi

    2016-07-01

    Itaka, T, Agemizu, K, Aruga, S, and Machida, S. G allele of the IGF2 ApaI polymorphism is associated with judo status. J Strength Cond Res 30(7): 2043-2048, 2016-Previous studies have reported that the insulin-like growth factor 2 (IGF2) ApaI polymorphism is associated with body mass index, fat mass, and grip strength. Competitive judo requires high levels of strength and power. The purpose of this study was to investigate the association between the IGF2 ApaI and ACTN3 R577X polymorphisms and judo status. The subjects were 156 male judo athletes from a top-level university in Japan. They were divided into 3 groups based on their competitive history: international-level athletes, national-level athletes, and others. Genomic DNA was extracted from the saliva of each athlete, and the maximal isometric strength of the trunk muscles and handgrip strength were measured. Genotyping by polymerase chain reaction-restriction fragment length polymorphism was used to detect IGF2 (rs680) and α-actinin-3 (ACTN3) (rs1815739) gene polymorphisms. The genotype frequencies of the 2 gene polymorphisms were compared among the 3 groups of judo athletes and controls. International-level judo athletes showed a higher frequency of the GG + GA genotype of the IGF2 gene than that of the national-level athletes and others. There was an inverse linear correlation between the frequency of the IGF2 AA genotype and level of judo performance (p = 0.041). Back muscle strength relative to height and weight was higher in subjects with the GG + GA genotype than in those with the AA genotype. Conversely, the ACTN3 R577X polymorphism was not associated with judo status. Additionally, no differences were found in back muscle or handgrip strength among the ACTN3 genotypes. In conclusion, the results indicate that the IGF2 gene polymorphism may be associated with judo status. PMID:26677828

  11. Connor H. G. Patros: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2015-11-01

    The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). The 2015 recipient is Connor H. G Patros. Patros was chosen for "an excellent research paper that examines the complex relationship between working memory, choice-impulsivity, and the attention-deficit/hyperactivity disorder (ADHD) phenotype." Patros's award citation, biography, and a selected bibliography are presented here. PMID:26618965

  12. 借鉴国际惯例 推行预先定价安排(APA)%Advanced Pricing Arrangment(APA):An International Practice

    Institute of Scientific and Technical Information of China (English)

    黄成得; 陈友伦

    2000-01-01

    @@ 国际预先定价安排(APA)的发展情况及最新趋势 预先定价安排在国际上已成为解决转让定价税务问题的理想办法.美国是世界上开展预先定价安排最有经验的国家,从1 992年正式预先定价安排程序实施以来,截止1 999年1 2月31日已完成231例预先定价安排.最近明确规定:一切预先定价安排经由国家的专门小组办理,小组成员包括:组长、副组长、经济师、会计师,资讯科技专家及资产价值评估员.税务当局可由申请人收取处理申请所需的成本费用,依纳税人销售规模,收取费用为5000-25000美元.

  13. ‘[A]rchitecture + [P]hotography + [A]rchive: the APA factor in the construction of historiography

    Directory of Open Access Journals (Sweden)

    Pierluigi Serraino

    2011-12-01

    Full Text Available The APA factor is the triangular foundation which the discursive edifice of Historiography in Modern Architecture rests upon. The production of architecture, its textual and photographic documentation, and the structured retrievability of visual records over time are the mutually interdependent links required for the lasting inclusion of particular buildings and their architects in institutional discourse. This paper illustrates the case study of the Italian architect Gian Luigi Giordani, designer of the Farmitalia Pharmaceutical Factory in Milan, and the Italian architectural photographer Giorgio Casali where the links holding together the APA factor are broken, resulting in their contemporary oblivion.

  14. Are Adolescents Less Mature than Adults?: Minors' Access to Abortion, the Juvenile Death Penalty, and the Alleged APA "Flip-Flop"

    Science.gov (United States)

    Steinberg, Laurence; Cauffman, Elizabeth; Woolard, Jennifer; Graham, Sandra; Banich, Marie

    2009-01-01

    The American Psychological Association's (APA's) stance on the psychological maturity of adolescents has been criticized as inconsistent. In its Supreme Court amicus brief in "Roper v. Simmons" (2005), which abolished the juvenile death penalty, APA described adolescents as developmentally immature. In its amicus brief in "Hodgson v. Minnesota"…

  15. Techniques for heating eccentrically located tumors with the BSD annular phased array system (APAS): Clinical experience

    International Nuclear Information System (INIS)

    The authors are currently investigating the potential for treatment optimization with the BSD APAS in tumors which are eccentrically located within the lower abdomen and pelvis. Attempts have been made to manipulate electric field (E-field) distribution during treatments through frequency changes and partial array activation (driving less than all four quadrants). Field shifts are qualitatively documented using the manufacturer's supplied diode array probes located at the patient/bolus interface in anterior, posterior and bilateral positions. Preliminary findings indicate that the internal E-field distributions can be manipulated to result in better treatment tolerance and better temperature distributions in selected target volumes. Phantom and clinical data are presented demonstrating the utility of these approaches

  16. Advocating for School Psychologists in Response to the APA's Proposed "Model Act for State Licensure of Psychologists"

    Science.gov (United States)

    Skalski, Anastasia Kalamaros

    2009-01-01

    On March 6, 2009, the APA Model Licensure Act Task Force released its second draft of the policy document known as the proposed "Model Act for State Licensure of Psychologists". This policy document serves as guidance to state legislatures for how they should set up their psychology licensing laws. The general expectations promoted in the model…

  17. A Reliable and Valid Weighted Scoring Instrument for Use in Grading APA-Style Empirical Research Report

    Science.gov (United States)

    Greenberg, Kathleen Puglisi

    2012-01-01

    The scoring instrument described in this article is based on a deconstruction of the seven sections of an American Psychological Association (APA)-style empirical research report into a set of learning outcomes divided into content-, expression-, and format-related categories. A double-weighting scheme used to score the report yields a final grade…

  18. Le B.A.-BA des normes de citation (6ème édition) de l'APA

    OpenAIRE

    Thirion, Paul; Durieux, Nancy

    2012-01-01

    Présentation très synthétique, en une seule page, des principales normes de citation de références bibliographiques de l'American Psychological Association (APA) pour les ouvrages, les chapitres d'ouvrages et les articles.

  19. Changes in the APA "Publication Manual": How the New Fifth Edition Will Affect Research Reporting in the Social Sciences.

    Science.gov (United States)

    Daniel, Larry G.

    The American Psychological Association (APA) has recently published the fifth edition of its "Publication Manual." This paper provides a brief overview of how this edition differs from previous editions and summarizes features of the new edition that will be likely to have an impact on social science research over the next several years. Both…

  20. Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis.

    Science.gov (United States)

    Nandakumar, Subhadra; Kannanganat, Sunil; Dobos, Karen M; Lucas, Megan; Spencer, John S; Amara, Rama Rao; Plikaytis, Bonnie B; Posey, James E; Sable, Suraj B

    2016-01-01

    Heterologous prime-boosting has emerged as a powerful vaccination approach against tuberculosis. However, optimal timing to boost BCG-immunity using subunit vaccines remains unclear in clinical trials. Here, we followed the adhesin Apa-specific T-cell responses in BCG-primed mice and investigated its BCG-booster potential. The Apa-specific T-cell response peaked 32-52 weeks after parenteral or mucosal BCG-priming but waned significantly by 78 weeks. A subunit-Apa-boost during the contraction-phase of BCG-response had a greater effect on the magnitude and functional quality of specific cellular and humoral responses compared to a boost at the peak of BCG-response. The cellular response increased following mucosal BCG-prime-Apa-subunit-boost strategy compared to Apa-subunit-prime-BCG-boost approach. However, parenteral BCG-prime-Apa-subunit-boost by a homologous route was the most effective strategy in-terms of enhancing specific T-cell responses during waning in the lung and spleen. Two Apa-boosters markedly improved waning BCG-immunity and significantly reduced Mycobacterium tuberculosis burdens post-challenge. Our results highlight the challenges of optimization of prime-boost regimens in mice where BCG drives persistent immune-activation and suggest that boosting with a heterologous vaccine may be ideal once the specific persisting effector responses are contracted. Our results have important implications for design of prime-boost regimens against tuberculosis in humans. PMID:27173443

  1. Sümeyra Tosun: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    Science.gov (United States)

    2014-11-01

    The Edwin B. Newman Graduate Research Award is given jointly by Psi Chi and APA. The award was established to recognize young researchers at the beginning of their professional lives and to commemorate both the 50th anniversary of Psi Chi and the 100th anniversary of psychology as a science (dating from the founding of Wundt's laboratory). The 2014 recipient is Sümeyra Tosun. Tosun was chosen for "an outstanding research paper that examines the cognitive repercussions of obligatory versus optional marking of evidentiality, the linguistic coding of the source of information. In English, evidentiality is conveyed in the lexicon through the use of adverbs. In Turkish, evidentiality is coded in the grammar. In two experiments, it was found that English speakers were equally good at remembering and monitoring the source of firsthand information and the source of non-firsthand information. Turkish speakers were worse at remembering and monitoring non-firsthand information than firsthand information and were worse than English speakers at remembering and monitoring non-firsthand information." Tosun's award citation, biography, and a selected bibliography are presented here. PMID:25486159

  2. QUANTITATIVE STUDY OF STUDENTS FROM CAMPO MOURÃO - PR APAE SCHOLL WITH RELATIVES PORTER OF

    Directory of Open Access Journals (Sweden)

    Michelle Alves Macena Lacerda¹; Ivone Maggione Fiori1

    2007-06-01

    Full Text Available About 25% of the Brazilian population have some kind of deficiency, among them 50% are mental. Brazilian situation isaggravated due to poverty conditions, misery, malnutrition, need of basic sanitation, disinformation, and precarious healthattendance. It is esteem that 350 million people with deficiency are excluded of any kind of medical attendance. For themaintenance of a person that carries a deficiency, 12,452 dollars are spent annually. On the other hand, “per capita” annual costof primary prevention is 20 dollars and of secondary prevention is 600 dollars. Population does not have access to informationabout causes, prevention and deficient child attendance and demonstrates wrong information, superstition and fears about thissubject. Thus, this study aimed to detect factors that may contribute with the improvement of preventive actions. Data obtainedfrom studies carried out with 100 APAE Scholl students in Campo Mourão allowed to analyze some common characteristicsabout them. One of these characteristics was that from all of 100 students under analysis, 52 had relatives with some kind ofmental, sensorial or additive deficiency. According to this index it is possible to conclude that people that have relatives withsome kind of deficiency also have great probabilities of generate children with deficiencies.

  3. Putative alternative polyadenylation (APA events in the early interaction of Salmonella enterica Typhimurium and human host cells

    Directory of Open Access Journals (Sweden)

    Fabian Afonso-Grunz

    2015-12-01

    Full Text Available The immune response of epithelial cells upon infection is mediated by changing activity levels of a variety of proteins along with changes in mRNA, and also ncRNA abundance. Alternative polyadenylation (APA represents a mechanism that diversifies gene expression similar to alternative splicing. T-cell activation, neuronal activity, development and several human diseases including viral infections involve APA, but at present it remains unclear if this mechanism is also implicated in the response to bacterial infections. Our recently published study of interacting Salmonella enterica Typhimurium and human host cells includes genome-wide expression profiles of human epithelial cells prior and subsequent to infection with the invasive pathogen. The generated dataset (GEO accession number: GSE61730 covers several points of time post infection, and one of these interaction stages was additionally profiled with MACE-based dual 3'Seq, which allows for identification of polyadenylation (PA sites. The present study features the polyadenylation landscape in early interacting cells based on this data, and provides a comparison of the identified PA sites with those of a corresponding 3P-Seq dataset of non-interacting cells. Differential PA site usage of FTL, PRDX1 and VAPA results in transcription of mRNA isoforms with distinct sets of miRNA and protein binding sites that influence processing, localization, stability, and translation of the respective mRNA. APA of these candidate genes consequently harbors the potential to modulate the host cell response to bacterial infection.

  4. APA guidelines: their importance and a plan to keep them current: 2013 annual report of the Policy and Planning Board.

    Science.gov (United States)

    2014-01-01

    When guidelines are approved by APA, they become association policy, and it is imperative that they remain current. The revision of guidelines poses several challenges to the association. These challenges range from the availability and allocation of resources to support the complicated processes involved in developing and updating these policies to the lack of a clearly defined process that includes identification of tasks, assignments of responsibilities, and so forth. For this reason, the APA Board of Directors asked the Policy and Planning Board (P&P) to work with the boards of the four directorates (i.e., the Education Directorate, the Practice Directorate, the Public Interest Directorate, and the Science Directorate) to create a proposal that would (a) make recommendations with regard to how the review and revision of guidelines documents might best be accomplished in accordance with the APA Strategic Plan and existing policies and procedures and (b) make suggestions regarding the association resources that might be required. The Board of Directors approved the proposed review process in December 2013. PMID:25046709

  5. 6-APA溶液物理化学特性的测定%Determination of the Physical and Chemical Properties of 6-APA Solutions

    Institute of Scientific and Technical Information of China (English)

    王鹏辉; 马文婵; 曹维峰

    2011-01-01

    6-氨基青霉烷酸(6-APA)是青霉素的母核,是半合成β-内酞胺抗生素生产的重要中间体.本文对于6-APA的溶液物理化学特性进行了分析与测定,其中包括溶解度、密度、粘度数据等,为6-APA工业化设计提供了依据.%6-aminopenicillanic acid (6-APA)is the nucleus of the penicillin molecule and serves as an important intermediate in the production of semisynthetie β-lactam antibiotics. This paper study the crystallization thermodynamic data, such as solubility, metastable zone and other basic data of 6-APA were measured based on experiments, which are useful for design and control of production of 6-APA.

  6. 我が国の事前確認(APA)の現状と課題 : 事前確認(APA)における納税者のジレンマ <研究ノート>

    OpenAIRE

    Mushiake, Chiharu; Saiki, Kenji

    2012-01-01

    移転価格税制の適用に係る問題に対しては,「移転価格事務運営要領」および「事前確認の状況─ APA レポート─」から確認できるとおり,事前確認制度による解決が図られており,特にバイラテラルAPA およびマルチラテラルAPA の利用が強く推奨されている。本研究ノートは,事前確認制度の意義を概観したうえで,納税者の立場から事前確認の利用におけるジレンマを指摘するものである。Givati(2009)の見解における事前確認を利用することによる懸念が,納税者におけるジレンマの一要因となっているものと考える。そのうえで,我が国の事前確認制度の法令による制度化を提言するものである。...

  7. Progress in the associated G-protein-coupled receptors (GPCRs) of aldosterone-producing adenoma (APA) pathogenesis%醛固酮瘤(APA)发病相关的G蛋白耦联受体(GPCRs)研究进展

    Institute of Scientific and Technical Information of China (English)

    徐曦

    2014-01-01

    醛固酮瘤(aldosterone-producing adenoma,APA)是原发性醛固酮增多症的一个重要亚型,约占30%~60%,是引起继发性高血压的重要病因.有关APA的发病机制,可见不同水平与角度的研究,但是对于APA的具体发病机制仍不清楚.本文就已知的与发病相关的G蛋白耦联受体(G-protein-coupled receptors,GPCRs)进行论述.

  8. Estratigrafía y petrología del sector noreste de sierra de Apas. Provincia del Chubut Stratigraphy and petrology of the Northeastern sector of Sierra de Apas. Chubut Province

    OpenAIRE

    M. Remesal; F.M. Salani; G.I. Massaferro; M.E. Cerredo

    2004-01-01

    La sierra de Apas, ubicada entre las provincias de Rio Negro y Chubut, forma parte del magmatismo de intraplaca emplazado durante el Paleogeno-Neógeno en el norte de la Patagonia extrandina. En el sector noreste se ha definido una estratigrafía integrada por: traquitas oscuras, flujos piroclásticos, traquitas claras, domos riolíticos y basaltos porfíricos y afíricos. Las traquitas oscuras, son relativamente más antiguas, tienen bajo porcentaje de fenocristales, y clasifican como traquitas- be...

  9. Frå Apan fin (1999) til Hej då, lilla apa! (2008). Bildebok og animasjonsfilm - resepsjon og medieestetikk

    OpenAIRE

    Mjør, Ingeborg

    2013-01-01

    Artikkelen analyserer animasjonsfilmen Hej då, lilla apa! (2008), ein adaptasjon av Anna-Clara Tidholms små barnsbildebok Apan fin (1999). Filmen har reformulert nokre av bokas motiv og lagt til nye motiv, og artikkelen prøver for det første å grunngi desse endringane i resepsjonsperspektiv, det vil seie at endringane er gjort av omsyn til små barns (12 år) resepsjon. For det andre kan ein sjå filmen som eit produkt av medieestetiske omsyn, den er laga på filmmediets premissar, som på visse m...

  10. Estratigrafía y petrología del sector noreste de sierra de Apas. Provincia del Chubut

    OpenAIRE

    M. Remesal; F.M. Salani; G.I. Massaferro; M.E. Cerredo

    2004-01-01

    La sierra de Apas, ubicada entre las provincias de Rio Negro y Chubut, forma parte del magmatismo de intraplaca emplazado durante el Paleogeno-Neógeno en el norte de la Patagonia extrandina. En el sector noreste se ha definido una estratigrafía integrada por: traquitas oscuras, flujos piroclásticos, traquitas claras, domos riolíticos y basaltos porfíricos y afíricos. Las traquitas oscuras, son relativamente más antiguas, tienen bajo porcentaje de fenocristales, y clasifican como traquitas- be...

  11. 维生素D受体Apa Ⅰ多态性与系统性红斑狼疮的相关性研究%Association of vitamin D receptor gene Apa Ⅰ polymorphism with systemic lupus erythematosus

    Institute of Scientific and Technical Information of China (English)

    夏艳辉; 罗雄燕; 武丽君; 杨明辉; 刘宁涛; 库尔班江; 谢传美; 唐中; 曾小峰

    2013-01-01

    Objective To determine the distribution of vitamin D receptor (VDR) gene Apa Ⅰ polymorphism and the possible association with systemic lupus erythematosus (SLE) in Chinese Han population.Methods Genomic DNA from 244 Chinese SLE patients and 162 sex and ethnically matched controls were typed for VDR Apa Ⅰ polymorphism by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).Frequency distribution was compared between patients and the controls using Chi-Square test.Clinical characteristics were analyzed between different Apa Ⅰ genotypes and between alleles using Chi-Square test and analysis of variance.Results There was no significant difference in the distribution frequencies of Apa Ⅰ alleles between SLE patients and the controls,but the distribution frequency of heterozygote Aa in SLE patients was higher than that in the controls (38.9% vs 22.2%,x2=12.442,P=0.000).The relative risk for heterozygote Aa was 2.232(95%CI=1.421-3.503,x2=12.442,P=0.000).No significant difference was observed between SLE patients and the controls with regard to homozygote AA or homozygote aa (P=0.098,P=0.067,respectively).Furthermore,when analyzing the effects of VDR Apa Ⅰ polymorphism on the symptoms of SLE,significant difference was observed,with SLE patients carrying heterozygote Aa developed serositis (P=0.000),and those carrying homozygote AA developed renal disorder (P=0.01) along with the presence of antiDNA antibody (P=0.014).Conclusion There is a significant association between VDR gene heterozygote Aa and the incidence of systemic lupus erythematosus in Han population of China,the heterozygote Aa is also involved in serositis.Although there is no association between homozygote AA and the incidence of systemic lupus erythematosus,homozygote AA is involved in renal disorder and has a positive effect on anti-dsDNA antibody production.%目的 检测维生素D受体(VDR)基因Apa Ⅰ多态性在系统性红斑狼疮(SLE)患者中的分布,并

  12. Calamitic Smectic A-Polar Smectic APA Transition Observed in Bent Molecules with Large Bent-Angle Central Core of 4,6-Dichlorobenzene and Alkylthio Terminal Tail

    Science.gov (United States)

    Nguyen, Ha; Kang, Sungmin; Tokita, Masatoshi; Watanabe, Junji

    2011-07-01

    New homologs of bent molecules with a large bent-angle central core of 4,6-dichloro benzene and an alkylthio terminal tail have been synthesized. Although the corresponding alkoxy-tail homologs show only the calamitic phases because of its large bent angles around 160°, the new homologs with an alkylthio tail exhibit the antiferroelectric smectic APA (SmAPA) banana phase that is transformed on cooling from the calamitic smectic A (SmA) phase. The biaxial polar packing of bent molecules in the SmAPA phase is considered to arise from the hindered rotation around the molecular long axis due to the expansion of the mesophase temperatures to a lower temperature region. This study indicates that the bent molecules, even with a large bent angle, have the potential to form a switchable banana phase with a remarkable decrease in its phase temperature range to around 60 °C.

  13. La recepción del estructuralismo lacaniano en el pensamiento de W. Baranger en el seno de la APA de 1976

    OpenAIRE

    Renovell, Estela Julia

    2013-01-01

    Willy Baranger es uno de los psicoanalistas dentro de la APA que introduce conceptos y citas lacanianos por la década de los 70 en la Argentina. Masotta que al inicio de esta década se había convertido en un referente del pensamiento estructuralista lacaniano, por fuera del circuito del psicoanálisis oficial de la APA; promovió la publicación de tres libros que resultaron fundamentales para la difusión de las ideas lacanianas en la Argentina. Situar la especificidad de la recepción del est...

  14. The O-mannosylation and production of recombinant APA (45/47 KDa protein from Mycobacterium tuberculosis in Streptomyces lividans is affected by culture conditions in shake flasks

    Directory of Open Access Journals (Sweden)

    Gamboa-Suasnavart Ramsés A

    2011-12-01

    Full Text Available Abstract Background The Ala-Pro-rich O-glycoprotein known as the 45/47 kDa or APA antigen from Mycobacterium tuberculosis is an immunodominant adhesin restricted to mycobacterium genus and has been proposed as an alternative candidate to generate a new vaccine against tuberculosis or for diagnosis kits. In this work, the recombinant O-glycoprotein APA was produced by the non-pathogenic filamentous bacteria Streptomyces lividans, evaluating three different culture conditions. This strain is known for its ability to produce heterologous proteins in a shorter time compared to M. tuberculosis. Results Three different shake flask geometries were used to provide different shear and oxygenation conditions; and the impact of those conditions on the morphology of S. lividans and the production of rAPA was characterized and evaluated. Small unbranched free filaments and mycelial clumps were found in baffled and coiled shake flasks, but one order of magnitude larger pellets were found in conventional shake flasks. The production of rAPA is around 3 times higher in small mycelia than in larger pellets, most probably due to difficulties in mass transfer inside pellets. Moreover, there are four putative sites of O-mannosylation in native APA, one of which is located at the carboxy-terminal region. The carbohydrate composition of this site was determined for rAPA by mass spectrometry analysis, and was found to contain different glycoforms depending on culture conditions. Up to two mannoses residues were found in cultures carried out in conventional shake flasks, and up to five mannoses residues were determined in coiled and baffled shake flasks. Conclusions The shear and/or oxygenation parameters determine the bacterial morphology, the productivity, and the O-mannosylation of rAPA in S. lividans. As demonstrated here, culture conditions have to be carefully controlled in order to obtain recombinant O-glycosylated proteins with similar "quality" in bacteria

  15. Vitamin-D receptor (VDR gene polymorphisms (Taq-I & Apa-I in Syrian healthy population

    Directory of Open Access Journals (Sweden)

    Shaden HADDAD

    2014-12-01

    Full Text Available The vitamin D endocrine system regulates bone metabolism and calcium homeostasis as well as cellular proliferation and differentiation. Vitamin D receptor (VDR mediates Vit-D activity, thus VDR gene polymorphisms may correlate with different diseases. This study aimed to determine the distribution of VDR gene (Taq-I and Apa-I polymorphisms using a RFLP in unrelated normal healthy individuals of Syrian population. Allelic frequencies were 65% vs 35% and 66% vs 34% for T vs t and A vs a alleles, respectively. Genotype distribution was 36%, 58% and 6% for TT, Tt and tt and 42%, 47% and 10% for AA, Aa and aa, respectively. These results demonstrate that the frequency and distribution of the VDR polymorphisms in Syrian population are different from other populations worldwide.

  16. Do Biochemical Markers and Apa I Polymorphism in IGF-II Gene Play a Role in the Association of Birth Weight and Later BMI?

    Directory of Open Access Journals (Sweden)

    Unqing Wu

    2013-05-01

    Full Text Available Background: The aim of the study was to explore the mechanisms underlying the association of birth weight with later body mass index (BMI from the biochemical markers related to metabolism and the Apa I polymorphism in IGF-II gene.Methods: A total of 300 children were selected randomly from the Macrosomia Birth Cohort in Wuxi, China. The height and weight were measured and blood samples were collected. Plasma concentrations of 8 biochemical markers were detected. Apa I polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymor­phism (PCR-RFLP.Results: Biochemical markers were detected for 296 subjects and 271 subjects were genotyped for the Apa I polymorphism. No association was found between birth weight and 8 biochemical markers. In boys, the BMIs of AA, AG and GG genotypes were 16.10 ± 2.24 kg/m2, 17.40 ± 3.20 kg/m2, 17.65 ± 2.66 kg/m2. And there was statistical difference among the three genotypes. But in girls, there was no statistical difference. The birth weights of AA, AG and GG genotypes were 3751.13 ± 492.43 g, 3734.00 ± 456.88 g, 3782.00 ± 461.78 g. And there was no statis­tical difference among the three genotypes.Conclusion: Biochemical markers are not associated with birth weight. Apa I polymorphism may be related to child­hood BMI, but it may be not associated with birth weight. Therefore, biochemical markers and Apa I polymorphism might not play a role in the association of birth weight and BMI.

  17. 6-APA中残留丙酮、甲基异丁基酮的测定%Determination on Residual Acetone and MIBK in 6-APA

    Institute of Scientific and Technical Information of China (English)

    赵娜; 宋雅丽; 郭云英

    2012-01-01

    采用直接进样色谱法测定,并用内标法(2-戊酮作内标物)定量,确定6-APA中残留丙酮、甲基异丁基酮的检测方法。经验证此法可准确测定6-APA中丙酮、甲基异丁基酮的残余量。%To develop a method for determination of residual acetone and MIBK in 6-APA through using injection chromatographic method and internal standard (2-pentanone) method. This method established on basis of verifica tion to determinate residual acetone and MIBK in 6-APA accurately.

  18. Association between VDR ApaI Polymorphism and Hip Bone Mineral Density Can Be Modified by Body Mass Index: A Study on Postmenopausal Chinese Women

    Institute of Scientific and Technical Information of China (English)

    Hong XU; Dong-Hai XIONG; Fu-Hua XU; Yuan-Yuan ZHANG; Shu-Feng LEI; Hong-Wen DENG

    2005-01-01

    Osteoporosis is a major public health problem for old people. Genetic factors are considered to be major contributors to the pathogenesis of postmenopausal osteoporosis. The vitamin D receptor (VDR)gene is a prominent candidate gene for the regulation of postmenopausal bone mass; however, despite extensive studies, controversy remains regarding its association with postmenopausal body mineral density (BMD)variation. In this study, a total of 260 healthy postmenopausal Chinese women were genotyped at the VDR ApaI locus using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Raw hip BMD was significantly associated with VDR ApaI polymorphism with and without adjusting for age(P=0.015 and 0.040, respectively). This genetic effect can explain 3.32% of hip BMD variation. However,the significant association vanished after correcting for both age and body mass index (BMI) (P=0.169). In addition, we observed a significant association between VDR ApaI polymorphism with unadjusted BMI(P=0.042) or BMI adjusted for age (P=0.049). The raw hip BMD was also found to be significantly correlated with BMI (r=0.517, P=0.0001), with BMI explaining 26.35% of the variation of hip BMD. All of these facts prompt us to conclude that the significant association between the VDR ApaI genotype and hip BMD may be modified by BMI in postmenopausal Chinese women. Our findings may partially explain the earlier inconsistent association results concerning the VDR gene and BMD, and highlight the importance of incorporating covariates such as BMI into osteoporosis association studies.

  19. Association between vitamin D receptor ApaI and TaqI gene polymorphisms and gestational diabetes mellitus in an Iranian pregnant women population.

    Science.gov (United States)

    Rahmannezhad, Golzar; Mashayekhi, Farideh Jalali; Goodarzi, Mohammad Taghi; Rezvanfar, Mohammad Reza; Sadeghi, Abdorrahim

    2016-04-25

    It has been proposed that variants of the nuclear vitamin D receptor (VDR) gene are associated with a susceptibility to type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). Our study was aimed to evaluate a possible association between the VDR ApaI (rs7975232) and TaqI (rs731236) gene polymorphisms and susceptibility to GDM in an Iranian pregnant women population. This case-control study was performed on a population of pregnant Iranian women, including 157 GDM and 157 non-GDM subjects.VDR ApaI and TaqI polymorphisms were assessed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Our finding showed that the genotypes frequency of VDR ApaI polymorphism was significantly different between GDM and non-GDM groups (χ(2)=8.5, P=0.014). The CC genotype increased the risk of GDM as compared to the AA genotype (AA vs.CC, OR=2.996, 95% CI=1.278-7.022, P=0.012). The genotype and allele frequencies of VDR TaqI polymorphism were significantly different between GDM and non-GDM subjects (χ(2)=7.27, P=0.026, χ(2)=4.08, P=0.043 respectively). A significant protection was shown against GDM in VDR TaqI genotypes and allele (TT vs.TC, OR=0.523, 95% CI=0.23-0.84, P=0.007, TT vs. TC+CC, OR=0.546, 95% CI=0.35-0.86, P=0.009, T vs. C, OR=0.711, 95% CI=0.511-0.99, P=0.043). In conclusion, our findings show a significant association between VDR ApaI and TaqI gene polymorphisms and the GDM at the investigated loci. PMID:26784653

  20. 乳状液膜包酶制备6-APA的研究%Preparation of 6-APA by Enzymatic Bioconversion in an Emulsion Liquid Membrane Reactor

    Institute of Scientific and Technical Information of China (English)

    陆强; 胡鸣; 熊丹柳; 邓修

    2001-01-01

    Production of 6-aminopenicillanic acid (6-APA) by hydrolysis using penicillin acylase (PA) was studied as a model of an enzymatic emulsion liquid membrane (ELM) process. The loss of PA activity was examined for various membrane compositions (organic solvent, surfactant, carrier). The effects of some experimental variables on the stability of emulsion were investigated. It was found that the choice of organic solvent greatly affected the stability of the emulsion. Increasing the concentration of the carrier in the membrane phase increases the transfer rate of substrate and products but also has a destabilizing effect on the emulsion. The recovery of 6-APA obtained by a di-carrier system (N263-N1923) was much higher than those when either of the dj-carriers was used separately. The whole process was controlled both by the enzymatic reaction rate and by the transfer rate of the substrate and the products, however, the ratio of them could be changed by varying the composition of the system. For an optimum condition, it was obtained that the recovery ratio of 6-APA was over 80% and the conversion of benzyl penicillin (PG) was up to 90% in the external phase after 30 minutes. Meanwhile, the breakage percentage of the emulsion was less than 2%.``

  1. The vitamin D receptor gene ApaI polymorphism is associated with increased risk of renal cell carcinoma in Chinese population.

    Science.gov (United States)

    Yang, Chunming; Li, Jia; Li, Yan; Wu, Di; Sui, Chengguang; Jiang, Youhong; Meng, Fandong

    2016-01-01

    Molecular epidemiologic studies previously reported that 1,25-dihydroxy vitamin D3 (1,25(OH)2 D3) appears to influence cancer risk. It exerts its activity through the intracellular vitamin D receptor (VDR), which regulates the transcription of genes. This study aimed to investigate the genetic association of VDR polymorphisms with renal cell carcinoma (RCC) risk in the Chinese population. The genotypes of five VDR polymorphisms (TaqI, BsmI, Cdx-2, ApaI, and FokI) were studied using polymerase chain reaction in 302 RCC patients and 302 healthy controls. ApaI variant AA and AC genotypes were found to be associated with a significantly increased risk of RCC compared with the CC genotype (OR = 2.60, 95% CI = 1.39-4.85 for AA vs. CC, and OR = 1.52, 95% CI = 1.08-2.13 for AC vs. CC). The AA genotype was also associated with a higher Fuhrman grade (OR = 2.87, 95% CI = 1.15-7.16 for AA vs. CC). No significant difference was found between the other four VDR polymorphisms and RCC risk. Our study suggests that VDR ApaI genotypes may be involved in the increased risk and progression of RCC in the Chinese Han population. PMID:27174575

  2. Analgesic effect of intrathecal APA microcapsulized NIH3T3/rPENK on neuropathic pain induced by CCI in rats%蛛网膜下腔移植APA-MH3T3/rPENK对大鼠神经痛的镇痛效应

    Institute of Scientific and Technical Information of China (English)

    曹靖; 王振全; 任秀花; 张华; 张宏伟; 臧卫东

    2009-01-01

    目的:探讨海藻酸钠一聚赖氨酸.海藻酸钠(APA)微囊化转鼠前脑啡肽原基因NIH3T3细胞(APA-NIH3T3/rPENK)移植对大鼠神经痛的镇痛作用.方法:50只SD大鼠随机分为5组:CCI(坐骨神经慢性压迫)组、假手术组、APA空囊组、NIH3T3/rPENK组和APA-NIH3T3/rPENK组.测定CCI组和假手术组手术前后,APA空囊组、NIH333/rPENK组和APA-NIH3T3/rPENK组移植前后CCI术侧热痛阈,观察腹腔注射纳洛酮对细胞镇痛效应的影响,同时用放射免疫法检测脑脊液灌流液中亮氨酸脑啡肽(L-EK)含量.结果:CCI术后7~33 d术侧后爪热痛阈明显低于非术侧后爪(P<0.05).APA空囊组移植前后热痛阈未见明显变化;移植后NIH3T3/rPENK组和APA-NIH3T3/rPENK组热痛阈都明显高于APA空囊组(P<0.05).移植15 d后NIH333/rPENK组热痛阈显著低于APA-NIH3T3/rPENK组(P<0.05).移植21 d后APA空囊组脑脊液灌流液中L-EK含量显著低于NIH3T3/rPENK组和APA-NIH333/rPENK组(P<0.05);NIH3T3/rPENK组脑脊液灌流液中L-EK含量显著低于APA-NIH3T3/rPENK组(P<0.05).结论:NIH333/rPENK或APA-NIH3T3/rPENK植入大鼠的蛛网膜下腔可以明显减轻神经痛大鼠的热痛敏感行为.APA-NIH3T3/rPENK效果更明显,提示APA微囊具有良好的免疫隔离作用.

  3. Estratigrafía y petrología del sector noreste de sierra de Apas. Provincia del Chubut Stratigraphy and petrology of the Northeastern sector of Sierra de Apas. Chubut Province

    Directory of Open Access Journals (Sweden)

    M. Remesal

    2004-12-01

    Full Text Available La sierra de Apas, ubicada entre las provincias de Rio Negro y Chubut, forma parte del magmatismo de intraplaca emplazado durante el Paleogeno-Neógeno en el norte de la Patagonia extrandina. En el sector noreste se ha definido una estratigrafía integrada por: traquitas oscuras, flujos piroclásticos, traquitas claras, domos riolíticos y basaltos porfíricos y afíricos. Las traquitas oscuras, son relativamente más antiguas, tienen bajo porcentaje de fenocristales, y clasifican como traquitas- benmoreítas. Las traquitas claras son porfíricas, y clasifican como comenditas. Su ubicación estratigráfica es confirmada por una edad K/Ar de 19 ± 2 Ma. Los flujos piroclásticos son predominantemente vítreos, cubren a las traquitas oscuras y tienen composiciones traquiandesíticas. La petrografía y geoquímica establecen una estrecha relación con las traquitas claras. El único cuerpo dómico en el área es el cerro Colorado, cuya composición corresponde a una riolita peralcalina ó comendita; una edad K/Ar de 24 ± 1 Ma establece por primera vez su relación temporal. La unidad efusiva más joven corresponde a lavas basálticas, agrupadas en afíricas y porfíricas. Se propone designar a las primeras como basaltos olivínicos transicionales en tanto que los basaltos porfíricos se subdividen en basaltos olivínicos alcalinos y hawaiitas. Los datos estratigráficos y geoquímicos sugieren que la asociación volcánica estudiada es el resultado de al menos dos etapas evolutivas. Una de ellas incluye los basaltos, traquitas claras, flujos claros y comenditas que muestran un patrón de cristalización fraccionada. Las traquitas oscuras, más viejas, corresponderían a otro estadio evolutivo.The volcanic building of Sierra de Apas (located on the limit between the Rio Negro and Chubut provinces is part of the Paleogene-Neogene intraplate magmatism of the northern Extrandean Patagonia. This contribution is focused on the northeastern of the Sierra

  4. APA Citation Style

    OpenAIRE

    2013-01-01

    This handbook is one of a series of four produced for the Acquisition Research Program (ARP) at the Naval Postgraduate School. The purpose of the ARP Handbook Series is to provide helpful information in a user friendly format to assist graduate students and others in improving their research and writing skills.

  5. Estratigrafía y petrología del sector noreste de sierra de Apas. Provincia del Chubut

    Directory of Open Access Journals (Sweden)

    M. Remesal

    2004-12-01

    Full Text Available La sierra de Apas, ubicada entre las provincias de Rio Negro y Chubut, forma parte del magmatismo de intraplaca emplazado durante el Paleogeno-Neógeno en el norte de la Patagonia extrandina. En el sector noreste se ha definido una estratigrafía integrada por: traquitas oscuras, flujos piroclásticos, traquitas claras, domos riolíticos y basaltos porfíricos y afíricos. Las traquitas oscuras, son relativamente más antiguas, tienen bajo porcentaje de fenocristales, y clasifican como traquitas- benmoreítas. Las traquitas claras son porfíricas, y clasifican como comenditas. Su ubicación estratigráfica es confirmada por una edad K/Ar de 19 ± 2 Ma. Los flujos piroclásticos son predominantemente vítreos, cubren a las traquitas oscuras y tienen composiciones traquiandesíticas. La petrografía y geoquímica establecen una estrecha relación con las traquitas claras. El único cuerpo dómico en el área es el cerro Colorado, cuya composición corresponde a una riolita peralcalina ó comendita; una edad K/Ar de 24 ± 1 Ma establece por primera vez su relación temporal. La unidad efusiva más joven corresponde a lavas basálticas, agrupadas en afíricas y porfíricas. Se propone designar a las primeras como basaltos olivínicos transicionales en tanto que los basaltos porfíricos se subdividen en basaltos olivínicos alcalinos y hawaiitas. Los datos estratigráficos y geoquímicos sugieren que la asociación volcánica estudiada es el resultado de al menos dos etapas evolutivas. Una de ellas incluye los basaltos, traquitas claras, flujos claros y comenditas que muestran un patrón de cristalización fraccionada. Las traquitas oscuras, más viejas, corresponderían a otro estadio evolutivo.

  6. Polimorfisme FokI, BsmI, ApaI, dan TaqI Gen Reseptor Vitamin D pada Kejadian Tuberkulosis Anak

    Directory of Open Access Journals (Sweden)

    Budi Setiabudiawan

    2010-12-01

    Full Text Available Tuberculosis (TB is a infection disease caused by Mycobacterium tuberculosis. Mycobacterium tuberculosis itself is not the only factor of TB. Polymorphism of vitamin D receptor (VDR gene is important on the susceptibility of TB. The aim was to find out the role of FokI, BsmI, ApaI, and TaqI VDR gene polymorphism on child TB. The observational analytic study with case control design was done in RSUP Dr. Hasan Sadikin Bandung and RSU Cibabat Cimahi, May 2008–March 2009. The subjects consisted of 42 children each for case (TB and control (non TB group, enrolled by consecutive sampling. The blood was analyzed for polymorphism of FokI, BsmI, ApaI, and TaqI VDR gene. Chi-square test, Mann-Whitney test, to calculate odds ratio (OR and 95% confidence interval (CI were used. The incidence of FokI VDR gene polymorphism in TB case group was 66.7% and 40.5% in control group (p=0.016, OR (95% CI: 2.94 (1.21–7.16. The FokI VDR gene polymorphism for TB group was 2.94 times greater than that for control group; while for BsmI, ApaI, and TaqI VDR gene polymorphism, there was no significant difference between TB case and control (p>0.05. It is concluded, FokI VDR gene polymorphism is a risk factor of child TB.

  7. Study on industrialization of penicillin direct process of 6-APA%青霉素直通法生产6-APA工业化研究

    Institute of Scientific and Technical Information of China (English)

    李士杰; 魏光涛; 张琳叶; 贾荣荣

    2014-01-01

    为了降低6-氨基青霉烷酸(6-APA)的生产成本,采用了直通、脱酯、萃取工艺对6-APA的生产工艺进行了改进,使得总收率和质量得到提高,大幅度降低了6-APA的生产成本,提高了6-APA及后续产品的市场竞争力.

  8. Considerations on the relevance of uncertainties and errors in the determination of the radioactive inventory and the waste properties in the Asse II repository (AP-A6)

    International Nuclear Information System (INIS)

    The considerations on the relevance of uncertainties and errors in the determination of the radioactive inventory and the waste properties in the Asse II repository (AP-A6) cover the following issues: Properties of the radionuclides related to uncertainties of the nuclide inventory: tritium, carbon-15, chlorine-36, uranium isotopes, plutonium isotopes, radium-226, neptunium-237, cobalt-60, nickel-64 and other nuclides. Non-radiological waste properties and status of the waste packages: non-radiological acceptance requirements, documented deviations of the acceptance requirements, advices for the manipulation of waste packages with deviating non-radiological properties during the decommissioning options retrieval and relocation.

  9. Predação oportunista de Artibeus planirostris (Spix, 1823) e Carollia perspicillata (Linnaeus, 1758) (Chiroptera, Phyllostomidae) por marsupiais e anuro na APA do Rio Curiaú, Amapá, Brasil Opportunistic predation of Artibeus planirostris (Spix, 1823) and Carollia perspicillata (Linnaeus, 1758) (Chiroptera, Phyllostomidae) by marsupials and anuran in the APA do Rio Curiaú, Amapá State, Brazil

    OpenAIRE

    Isai Jorge de Castro; Claudia Regina Silva; Arley José Silveira Da Costa; Ana Carolina Moreira Martins

    2011-01-01

    Durante estudos com morcegos em floresta de várzea na APA do Rio Curiaú, Amapá, Brasil, observamos três casos de predações oportunistas de morcegos frugívoros capturados em redes de neblina. Duas destas predações ocorreram por marsupiais e uma por anuro. Artibeus planirostris (Spix, 1823) (Chiroptera, Phyllostomidae) foi predado por Didelphis marsupialis Linnaeus, 1758 e Philander opossum (Linnaeus, 1758) (Didelphimorphia, Didelphidae). Carollia perspicillata (Linnaeus, 1758) (Chiroptera, Phy...

  10. The h index of the presidents of the American Psychological Association (APA through journal articles included in the Web of Science database

    Directory of Open Access Journals (Sweden)

    Gualberto Buela-Casal

    2011-01-01

    Full Text Available El presente estudio descriptivo analiza los índices h de los presidentes de la American Psychological Association (APA desde 1940 hasta la actualidad. El índice h se calcula teniendo en cuenta el número de artículos publicados en las revistas de la Web of Science (WOS y las citas recibidas por los mismos en dicha base de datos. No se estableció un periodo de búsqueda y, por tanto, se analizaron todos los resultados incluidos en la WOS. El número total de resultados analizados fue de 16.676, de los cuales 3.734 fueron de los presidentes de la APA. Los resultados se presentan en forma de ranking y ponen de manifiesto que Albert Bandura y Alan Kazdin son los presidentes con un índice h más elevado, y en entre estos y los demás existe una diferencia considerable. Los resultados hacen especular que el criterio de productividad en artículos científicos no fue el criterio más importante para presidir esta institución.

  11. The association of vitamin D receptor gene Apa Ⅰ and Bsm Ⅰ polymorphism with systemic lupus erythematosus%维生素D受体Apa Ⅰ和Bsm Ⅰ位点基因多态性与系统性红斑狼疮相关性研究

    Institute of Scientific and Technical Information of China (English)

    罗雄燕; 唐中; 赵岩; 曾小峰; 袁国华; 武丽君; 陈龙; 杨明辉; 廖涛; 刘宁涛; 库尔班江; 谢传美; 史冉庚

    2012-01-01

    Objective To determine the distribution of vitamin D receptor (VDR) gene Apa Ⅰ and Bsm Ⅰ polymorphism in systemic lupus erythematosus (SLE) and the association with SLE in Chinese Han patients.Methods Genomic DNA from 244 Chinese SLE patients and 162 sex and ethnically matched controls were typed for VDR Apa Ⅰ and Bsm Ⅰ polymorphism combination by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Clinical characteristics were analyzed between different Apa ] and Bsm Ⅰ genotypes.Results There was no significant difference between the distribution frequencies of allelic gene A and a in SLE patients and the controls,but the distribution frequency of genotypes heterozygote Aa in SLE patients was higher than that in the controls ( 38.9% vs 22.2%,x2 =12.442,P =0.000).There was no significant difference between the distribution frequency of allelic gene and genotypes of Bsm Ⅰ in SLE patients and the controls ( P > 0.05 ).However,there was significant difference between the distribution frequencies of Apa Ⅰ and Bsm Ⅰ genotypes combination in SLE patients and the controls (x2 =18.226,P =0.006).The distribution frequency of genotypes Aa-bb in SLE patients was higher than that in the controls ( 32.4% vs 17.9%,x2 =10.449 P =0.001 ),while the distribution frequency of genotypes Aa-bb in SLE patients was lower than that in the controls (30.3% vs 42.0%,x2 =5.808,P =0.016). Furthermore,analyzing the effect of VDR Apa Ⅰ and Bsm Ⅰ polymorphism combination to the symptoms of SLE,significant difference was observed in SLE patients carrying Aa-bb genotypes involved in serositis ( P =0.003 ),hematological system disorder ( P =0.021 ),and anti-Sm antibodies ( P =0.01 ) compared with other genotypes.Conclusion There is significant association between Apa Ⅰ and Bsm Ⅰ gene polymorphism Aa-bb genotypes and the incidence of SLE in the Han population of China,and genotype Aa-bb is more involved in serositis,hematological system

  12. ASPECTOS DA ESTRUTURA POPULACIONAL DO Trachelyopterus coriaceus, AMARRA TARRAFA, VALENCIENNES, 1840 (SILURIFORMES, AUCHENIPTERIDAE NA APA DO RIO CURIAÚ, ESTADO DO AMAPÁ, BRASIL

    Directory of Open Access Journals (Sweden)

    Paulo Arthur de Abreu Trindade

    2014-04-01

    Full Text Available A espécie Trachelyopterus coriaceus, conhecida popularmente como amarra tarrafa, está entre as espécies de peixes residentes da Área de Proteção Ambiental (APA do rio Curiaú no Amapá. O estudo avaliou a estrutura populacional da espécie T. Coriaceus na APA do rio Curiaú, através das relações peso-comprimento, proporção sexual e estrutura da população em crescimento. A amostragem foi realizada entre Abril de 2007 e Fevereiro de 2008, levando em conta os períodos de maior e menor pluviosidade (Cheia e Seca. No total, foram coletados 45 indivíduos de T. Coriaceus. Os machos foram maiores que as fêmeas, entretanto as fêmeas foram mais pesadas que os machos. A espécie apresentou incremento alométrico positivo. A proporção foi de 1,14F:1M . A partir da estrutura em comprimento sazonal e bimestral  foi possível observar que houve um maior número de indivíduos de ambos os sexos entre as classes 70 – 80 mm. Observou-se também diferença no comprimento total dos indivíduos apenas em relação aos bimestres. Fatores como temperatura, época do ano, alimentação, estádio de maturidade, sexo e períodos do ano, podem ser os causadores das diferenças nos aspectos da estrutura da população de T. Coriaceus  na APA do rio Curiaú. Palavras-chave: Amazônia, Crescimento, Alometria, proporção sexual, Trachelyopterus coriaceus. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v4n1p100-105

  13. 中日韩APA比较及对我国的启示%A Comparison of APAs among Japan, Korea and China and Their Implications

    Institute of Scientific and Technical Information of China (English)

    李本贵; 刘馨颖

    2006-01-01

    通过对中日韩三国APA实施情况及程序的比较,得出以下启示:中国的APA不仅要针对境内的外商投资企业,还要为中国企业走出去提供相应的税收服务;应多签订双边或多边APA;APA的重点应放在制造业和零售业的纳税人;APA的管理权限应相对集中;APA适用的时间应与国际惯例基本一致.

  14. Comparative Analysis of Loading Mode Between RLWT and APA Rutting Test%RLWT与APA车辙试验加载模式比较分析

    Institute of Scientific and Technical Information of China (English)

    张俊标; 徐科; 张肖宁

    2006-01-01

    旋转车辙仪(RLWT-Rotary Loaded Wheel Tester or Rutmeter)于20世纪90 年代末开始在美国出现,因其轻便、易用,迅速受到关注.研究表明,RLWT与沥青路面分析仪(APA)、国际车辙仪的相关性都不理想.本文利用数字图像处理技术对RLWT与APA车辙试验的加载模式进行了分析,通过量测RLWT试件、APA试件与原样试件中粗集料颗粒长轴与X轴夹角的差异,得出结论:RLWT与APA车辙试验的加载模式存在较大差异.

  15. Introduction to the special issue: 50th anniversary of APA Division 28: The past, present, and future of psychopharmacology and substance abuse.

    Science.gov (United States)

    Stoops, William W; Sigmon, Stacey C; Evans, Suzette M

    2016-08-01

    This is an introduction to the special issue "50th Anniversary of APA Division 28: The Past, Present, and Future of Psychopharmacology and Substance Abuse." Taken together, the scholarly contributions included in this special issue serve as a testament to the important work conducted by our colleagues over the past five decades. Division 28 and its members have advanced and disseminated knowledge on the behavioral effects of drugs, informed efforts to prevent and treat substance abuse, and influenced education and policy issues more generally. As past and current leaders of the division, we are excited to celebrate 50 years of Division 28 and look forward to many more successful decades for our division and its members. (PsycINFO Database Record PMID:27454671

  16. Expectation and Satisfaction of Parents or Tutors of Users of APAE Assisted at Special Patient Dental Clinic of Dentistry School of Montes Claros State University, Unimontes/MG

    Directory of Open Access Journals (Sweden)

    Luiza Augusta Rosa ROSSI-BARBOSA

    2007-03-01

    Full Text Available Objective: To evaluate expectation and satisfaction of parents/tutors of users of the Association of Parents and Friends of People with Disability (APAE assisted at the clinic of special patients of the Dentistry School of Unimontes, during the year of 2004 and the first school semester of 2005. Method: In the first consultation, 46 people were evaluated concerning expectation of clinical assistance and, in the end of the treatment, 89.0% of these people answered a satisfaction questionnaire. The statistical analysis applied were Pearson Qui-square test and Fisher exact test (p<0.05. Results: 84.8% have already been assisted at Dental Clinics at Unimontes. Considering expectation of assistance, 71.7% expected dental fillings, 65.2% dental prophylaxes, 45.7% treatment with speech-language pathologist, 41.3% treatment with physiotherapist, 37.0% tooth extraction and 23.9% treatment for tooth pain. Relation to satisfaction, 78.1% conceptualized dental assistance as great and 21.9% as good. Professor recommendations to students were classified as great by 75.6% of interviewed. Considering professional recommendations, 97.5% considered important those given by dentist, 56.1% by speech-language pathologist and 56.1% by physiotherapist. Conclusion: The most frequent expectations reported by the parents/tutors of the users of the clinics have involved the surgical and restorative dental treatment. Researchers were satisfied with the dental assistance. A significant number of users of the APAE were not assisted by physiotherapist and by speech-language pathologist, having, as a result, a low percentage in the evaluation of these services.

  17. Segregação social como externalização de conflitos ambientais: a elitização do meio ambiente na APA-Sul, Região Metropolitana de Belo Horizonte Social segregation like externalizing environmental problems: the elitization of the environment in the APA-Sul, Metropolitan Region of Belo Horizonte

    Directory of Open Access Journals (Sweden)

    Klemens Laschefski

    2008-01-01

    Full Text Available Este trabalho trata das relações de poder no conselho consultivo da APA-Sul, uma unidade de conservação localizada na Região Metropolitana de Belo Horizonte. Observa-se uma sub-representação dos setores populares, e os representantes de renda média-alta temem a favelização da região. Conseqüentemente, o conflito ambiental surge em torno da perda da qualidade ambiental nas referidas áreas, em parte associada às alternativas de habitação popular, abrindo oportunidade para discursos que justifiquem a segregação social no espaço e a elitização da paisagem em questão.This paper talks about the power relations within the consultative council of the APA-Sul, a conservation area situated in the Metropolitan Region of Belo Horizonte. There the lower-class sectors are apparently underrepresented and higher middle class representatives are concerned about the slumisation of the region. Consequently an environmental conflict arises about the loss of "environmental quality" of the area, partly associated with lower class housing, providing opportunities of discourses to justify social segregation in space and the elitization of the landscape at stake.

  18. Association of Vitamin D Receptor Apa I Gene Polymorphism and Immunological Abnormality in Patients with Vitiligo%白癜风患者维生素D受体Apa I基因多态性及免疫异常的研究

    Institute of Scientific and Technical Information of China (English)

    孙越; 韩菁; 吴瑞勤; 谢匡成; 朱光斗; 施伟民

    2011-01-01

    Objective To investigate the association between vitamin D receptor (VDR) Apa Ⅰ gene polymorphism and immunological abnormality on vitiligo patients. Methods VDR genotypes of 46 vitiligo patients and 50 healthy controls were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP). We also measured the levels of immunoglobulin IgG, IgM, IgA and complements C3, C4 and T lymphocyte subpopulations CD3+, CD4+ and CD8+ of peripheral blood. Results ①There was significant difference in genotype distribution of VDR-Apa Ⅰ polymorphisms between vitiligo patients, whose frequency of aa is higher(P<0.05), and normal controls. ② Vitiligo patients with Aa, aa had higher level of IgA than control cases, and the C3 measured in aa genotype showed the same trend (P<0.01). ③ Compared with normal controls,the percentage of CD3+ was significantly lower in vitiligo patients with aa genotype (P<0.05). Conclusion It suggests that VDR is a susceptible gene for involving in vitiligo, and aa is the susceptible genotype·for vitiligo patients. Immunological abnormality may exist in vitiligo patients with aa genotype. Our study also indicates that the pathogenesis of vitiligo might have some connection with VDR gene and immunological abnormality.%目的 探讨白癜风维生素D(VDR)受体Apa I基因多态性及其与免疫异常的关系.方法 采用聚合酶链反应和限制性片段长度多态性方法,对46例白癜风患者和50例健康人的VDR Apa I基因多态性进行分析,以及各基因型与外周血免疫球蛋白IgA、IgM、IgG,补体C3、C4以及T细胞亚群CD3+、CD4+、CD8+之间的关系.结果 ①VDR-Apa I位点的aa基因型在白癜风患者中出现的频率高于正常对照组(P<.05).②Aa、aa基因型组白癜风患者血清免疫球蛋白IgA水平显著低于正常对照组(P<0.05与P<0.01),aa基因型患者补体C3水平显著低于正常对照组(P<0.01).③aa基因型组白癜风患者的CD3+T淋巴细

  19. Qualidade da pastagem nativa obtida por diferentes métodos de amostragem e em diferentes solos na Apa do Ibirapuitã, Brasil Quality of natural pasture evaluated with different methods and soils at the Apa of Ibirapuitã, Brazil

    Directory of Open Access Journals (Sweden)

    Vicente Celestino Pires Silveira

    2005-06-01

    Full Text Available O estado do Rio Grande do Sul apresenta ecossistemas heterogêneos, devido ao grande número de tipos de solo e à variação em altitude e clima, que se reflete na diversidade da composição florística das diferentes comunidades vegetais. A Área de Proteção Ambiental do Ibirapuitã (APA do Ibirapuitã, é a única unidade de conservação federal, representante do bioma campos sulinos no Brasil. O objetivo deste trabalho foi obter informação sobre a qualidade do campo natural oriundo de três tipos de solos predominantes na APA do Ibirapuitã: Basalto superficial, Basalto profundo e Arenito obtidos por três formas de amostragem: Corte de emparelhamento, Simulação de pastejo através de coleta manual e Corte total acima da fração mantilho. Os dados foram coletados mensalmente, no período de outubro/2001 a setembro/2003. A pastagem nativa no solo de Basalto superficial apresenta forragem com qualidade nutricional superior quando comparado ao Basalto profundo e ao Arenito, comprovada pelas diferentes análises de qualidade realizadas. O método de coleta de amostras de forragem de pastagem nativa somente não influencia os resultados da análise de Fibra em Detergente Neutro. Os resultados indicam a simulação de pastejo como um método adequado de amostragem para avaliação da qualidade da pastagem nativa, devido à sua efetividade e facilidade de coleta.Heterogeneous ecosystems are found in the state of Rio Grande do Sul as a consequence of the great number of soil types and variation in altitude and climate. These conditions reflect on the great variety of flora present in the grassland communities. The Area of Environmental Protection of the Ibirapuitã (APA of Ibirapuitã is the only conservation unit under federal jurisdiction representative of the Campos bioma in Brazil. The objective of this work was to obtain information about the quality of the natural pasture on three types of soils in APA of Ibirapuitã: Superficial

  20. Referenciación bibliográfica en ciencias de la educación: criterios de la APA y un ejemplo de gestión a través del programa END-NOTE

    OpenAIRE

    Cubo Delgado, Sixto; González Gómez, José Juan; González Chaves, Silvia

    2004-01-01

    Whith this paper we aim at offering a global picture of the criteria of bibliographical reference that is more frequently used in the educational field. We specially deal with the criteria proposed by the American Psychological Association (APA) for being the ones more used in this context.After the exposition fo the above mentioned criteria and the reference to several works as example, we propose some procedures to index the documents obtained by electronic resources, emphasizing the intern...

  1. The analgesic effect of APA microcapsulized BCCs subarachnoid transplantation on animal models of neuropathic pain%APA微囊化BCCs蛛网膜下腔移植对大鼠慢性神经性疼痛的镇痛效应

    Institute of Scientific and Technical Information of China (English)

    徐龙河; 薛毅珑; 罗芸; 郭水龙; 张宏

    2004-01-01

    目的:观察 APA 微囊化牛肾上腺嗜铬细胞(BCCs) 移植对大鼠慢性神经性疼痛的作用.方法: SD 大鼠 4 组,即对照组(C 组),正常大鼠;单纯 CCI 组,右侧坐骨神经松结扎;CCI 注入 APA 组和 APA-BCCs 组,CCI 模型后 7 d,蛛网膜下腔分别移植 500~600 个 APA 空囊和 5×106 个 APA 微囊化 BCCs.测定各组移植后 7 d 至 42 d 的触诱发痛阈值(g)和 CO2 激光刺激痛阈值(ms).并取脊髓行 TH、 ENK、DβH 免疫组化检测.结果:APA-BCCs 组结扎侧触诱发痛阈值和 CO2 痛阈值在移植后 7~42 d 均高于 CCI 组和 APA 组(P0.05).移植后的 BCCs TH 染色阳性,脊髓软膜可见到 DβH 和 ENK 免疫组化染色阳性.结论: APA 微囊化 BCCs 蛛网膜下腔移植可缓解 CCI 模型大鼠的痛觉过敏和触诱发痛,ENK 和 NE 参与其镇痛作用机制.

  2. Parâmetros nutricionais da pastagem natural em diferentes tipos de solos na APA do Ibirapuitã, Rio Grande do Sul - Brasil Nutritional parameters of natural pasture in different soils at APA of Ibirapuitã, Rio Grande do Sul - Brazil

    Directory of Open Access Journals (Sweden)

    Vicente Celestino Pires Silveira

    2006-12-01

    Full Text Available O desempenho de ruminantes domésticos é influenciado por fatores intrínsecos ao animal, ao alimento e pela interação entre animal e alimento. O trabalho foi realizado na Estância do 28, pertencente à Fundação Maronna, Alegrete - RS, dentro da APA do Ibirapuitã. Para representar o fator solo, foram escolhidos os três tipos predominantes da APA do Ibirapuitã: Basalto Superficial, Basalto Profundo e Arenito. As amostras da pastagem natural foram retiradas por simulação de pastejo, através de coleta manual. Os parâmetros nutricionais avaliados foram: proteína bruta, fibra em detergente neutro e taxa de degradação da matéria seca. A forragem da pastagem natural oriunda do solo Basalto Superficial apresentou diferença significativa (PIntrinsic animal and food factors and the interaction between them influence the performance of domestic ruminants. This study was done at Estância do 28, property of the Maronna Foundation, Alegrete - RS, inside the Ibirapuitã Area of Environmental Protection. In order to represent soil as a factor, the three main soil types were chosen: Superficial Basalt, Deep Basalt and Sandy. Hand plucking methods were used to obtain samples of natural pasture. Nutritional parameters considered were crude protein, neutral detergent fiber and dry matter degradation rate. The forage from natural pasture of the Superficial Basalt presented significant difference (P<0.05 in crude protein rates over the other two types of soil, which did not differ amongst themselves. The highest rate of neutral detergent fibre (84.54% was obtained in pasture originated from Sandy soil, in relation to Superficial and Deep Basalt, with values of 74.53% and 77.98%, respectively. There was also a significant difference in the degradation rate of dry matter (P<0.05. Sandy soil pasture presented an intermediate degradation value (3.61% h-1, not differing from other soils. The forage from natural pastures present similar degradation rates

  3. FORÓFITOS PREFERENCIAIS DE ORQUÍDEAS EPÍFITAS NA APA ILHA DO COMBU, BELÉM, PARÁ, BRASIL

    Directory of Open Access Journals (Sweden)

    Tonny David Santiago Medeiros

    2014-10-01

    Full Text Available Foi avaliada a correlação da abundância de orquídeas epífitas com o tipo de casca dos forófitos e a influência do DAP sobre a abundância e a riqueza na Área de Proteção Ambiental (APA Ilha do Combu, Belém, Pará, Brasil. O estudo foi realizado em 2,85 ha, a partir da demarcação de 114 transectos de 5 m x 50 m, onde foram mensurados todos os forófitos com DAP ≥ 20 cm e anotadas as características da casca, e identificadas as orquídeas epífitas. A correlação entre o tipo de casca dos forófitos e a abundância de orquídeas foi verificada através do número de epífitas por forófitos na espécie arbórea x, e também da razão (n.° epífitas/n.° forófitos para forófitos rugosos e não-rugosos. Os diâmetros foram categorizados em classes para verificar a influência do DAP sobre a abundância e a riqueza. Trinta e cinco espécies de forófitos (73% apresentaram casca rugosa, com destaque para Hevea brasiliensis e Carapa guianensis que foram os mais amostrados (58 e 42 e mais expressivos em número de orquídeas epífitas; a razão de epífitas por forófitos foi maior em troncos com casca não-rugosa. As classes de diâmetro 2 (31,8┤ 63,7 e 3 (63,7┤ 95,5 registraram as maiores abundâncias de orquídeas epífitas. A abundância de orquídeas epífitas é influenciada pela rugosidade da casca e correlacionada aos maiores diâmetros dos forófitos. Palavras-chave: interação, hospedeiro, orquidaceae, floresta de várzea, Amazônia. DOI: http://dx.doi.org/10.18561/2179-5746/biotaamazonia.v4n3p1-4

  4. BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR and Association with Lumbar Spine Pathologies: An Italian Case-Control Study.

    Directory of Open Access Journals (Sweden)

    Alessandra Colombini

    Full Text Available Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR BsmI (rs1544410, ApaI (rs7975232, and TaqI (rs731236 are commonly studied in several pathologies. We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an Italian cohort of 266 patients with lumbar spine disorders assessed by Magnetic Resonance Imaging and 252 asymptomatic controls. The exposure to putative risk factors was evaluated by a questionnaire. Polymorphisms were detected by PCR-RFLP and TaqMan® SNP Genotyping Assay. The results were statistically adjusted for the identified conventional risk factors. The three SNPs were in linkage disequilibrium. For all cases BbAaTT was a 3-fold risk factor OR = 3.38, whereas bbAATT (OR = 0.22, and bbaaTT (OR = 0.47 genotypes were found to be protective. Specifically, for patients affected by disc herniation only (n = 88 and all lumbar pathologies excluding stenosis and/or spondylolistesis (n = 215 B allele, Bb, Aa, and BbAaTT genotypes were risky, whereas b allele, bb, aa, and bbaaTT genotypes were protective. In patients affected by osteochondrosis with or without disc hernation (n = 50, T allele, Aa, and bbAaTT genotypes were risky, whereas t allele, AA, tt genotypes were protective. In patients affected by stenosis and/or spondylolistesis (n = 51 no significant associations were found. This is the first study showing an association of the three genetic VDR variants BsmI, ApaI, and TaqI and lumbar spine pathologies. Our study contributes to delineate genetic risk factors for specific subgroups of patients with lumbar spine pathologies highlighting the importance of haplotype analysis, and of detailed clinical evaluation of the patients for identification of genetic biomarkers.

  5. BsmI, ApaI and TaqI Polymorphisms in the Vitamin D Receptor Gene (VDR) and Association with Lumbar Spine Pathologies: An Italian Case-Control Study

    Science.gov (United States)

    Colombini, Alessandra; Brayda-Bruno, Marco; Lombardi, Giovanni; Croiset, Samantha Jennifer; Ceriani, Cristina; Buligan, Cinzia; Barbina, Mattia; Banfi, Giuseppe; Cauci, Sabina

    2016-01-01

    Three adjacent single nucleotide polymorphisms of the vitamin D receptor gene (VDR) BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) are commonly studied in several pathologies. We aimed to evaluate the distribution of VDR BsmI, ApaI, and TaqI allele, genotype, and haplotype frequencies in an Italian cohort of 266 patients with lumbar spine disorders assessed by Magnetic Resonance Imaging and 252 asymptomatic controls. The exposure to putative risk factors was evaluated by a questionnaire. Polymorphisms were detected by PCR-RFLP and TaqMan® SNP Genotyping Assay. The results were statistically adjusted for the identified conventional risk factors. The three SNPs were in linkage disequilibrium. For all cases BbAaTT was a 3-fold risk factor OR = 3.38), whereas bbAATT (OR = 0.22), and bbaaTT (OR = 0.47) genotypes were found to be protective. Specifically, for patients affected by disc herniation only (n = 88) and all lumbar pathologies excluding stenosis and/or spondylolistesis (n = 215) B allele, Bb, Aa, and BbAaTT genotypes were risky, whereas b allele, bb, aa, and bbaaTT genotypes were protective. In patients affected by osteochondrosis with or without disc hernation (n = 50), T allele, Aa, and bbAaTT genotypes were risky, whereas t allele, AA, tt genotypes were protective. In patients affected by stenosis and/or spondylolistesis (n = 51) no significant associations were found. This is the first study showing an association of the three genetic VDR variants BsmI, ApaI, and TaqI and lumbar spine pathologies. Our study contributes to delineate genetic risk factors for specific subgroups of patients with lumbar spine pathologies highlighting the importance of haplotype analysis, and of detailed clinical evaluation of the patients for identification of genetic biomarkers. PMID:27149110

  6. Predação oportunista de Artibeus planirostris (Spix, 1823 e Carollia perspicillata (Linnaeus, 1758 (Chiroptera, Phyllostomidae por marsupiais e anuro na APA do Rio Curiaú, Amapá, Brasil Opportunistic predation of Artibeus planirostris (Spix, 1823 and Carollia perspicillata (Linnaeus, 1758 (Chiroptera, Phyllostomidae by marsupials and anuran in the APA do Rio Curiaú, Amapá State, Brazil

    Directory of Open Access Journals (Sweden)

    Isai Jorge de Castro

    2011-03-01

    Full Text Available Durante estudos com morcegos em floresta de várzea na APA do Rio Curiaú, Amapá, Brasil, observamos três casos de predações oportunistas de morcegos frugívoros capturados em redes de neblina. Duas destas predações ocorreram por marsupiais e uma por anuro. Artibeus planirostris (Spix, 1823 (Chiroptera, Phyllostomidae foi predado por Didelphis marsupialis Linnaeus, 1758 e Philander opossum (Linnaeus, 1758 (Didelphimorphia, Didelphidae. Carollia perspicillata (Linnaeus, 1758 (Chiroptera, Phyllostomidae foi predado por Leptodactylus pentadactylus (Laurenti, 1768 (Anura, Leptodactylidae. A vocalização dos morcegos provavelmente atraiu os marsupiais para a rede, onde estes os predaram aproveitando que estavam presos. Este tipo de interação pode ocorrer naturalmente, no entanto, com maior dificuldade de registro.We observed three occasional predations of bats captured in mist nets by marsupials and a frog during studies in a várzea forest in the Amapá state. Artibeus planirostris (Spix, 1823 (Chiroptera, Phyllostomidae was preyed upon by Didelphis marsupialis Linnaeus, 1758 and Philander opossum (Linnaeus, 1758 (Didelphimorphia, Didelphidae. Carollia perspicillata (Linnaeus, 1758 (Chiroptera, Phyllostomidae was preyed on by Leptodactylus pentadactylus (Laurenti, 1768 (Anura, Leptodactylidae. The bats vocalizations probably attracted the marsupials and a frog to the mist nets where they preyed. This interaction form can occur naturally, however, are more difficult to observed.

  7. EPS-APA顺应国际节能减碳发展理念%EPS-APA Conforms to the Developing Concept of Energy Conservation and Carbon Dioxide Reduction

    Institute of Scientific and Technical Information of China (English)

    张国锋

    2010-01-01

    @@ 2009年,宝马、采埃孚转向系统部门与康迪泰克公司共同开发了一套具有轴平衡(APA)电子机械转向系统(电动助力转向系统,简称EPS).康迪泰克为电动助力转向系统的同步带驱动装置开发了斜齿带(CONTI SLT POWER).

  8. Evaluación de las potencialidades para el serodiagnóstico de la tuberculosis en Cuba del antígeno APA45/47 kDa de Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Astrid Ramos Mori

    2004-01-01

    Full Text Available La tuberculosis (Tb continúa siendo la enfermedad infecciosa de mayor prevalencia en el mundo, no solo en países subdesarrollados, sino también, en los desarrollados donde la Tb ha reemergido en los últimos años y constituye uno de los principales problemas de salud. Cuba se encuentra entre estos últimos. Teniendo en cuenta que alrededor de un tercio de la población mundial está infectada con el agente causal, el bacilo Mycobacterium tuberculosis, el diagnóstico temprano y eficaz es vital para el control de la expansión de la enfermedad y su mortalidad. Empleando la metodología del ELISA se evaluó el complejo antigénico 45/47 kDa o APA (antígeno rico en prolina y alanina de M. tuberculosis para el serodiagnóstico de la Tb en la población cubana. Para ello, se determinaron los anticuerpos reactivos contra dicha proteína recombinante obtenida de E. coli, presentes en los sueros de individuos sanos vacunados con BCG, enfermos de Tb e individuos sanos no vacunados mayores de 60 años. Los resultados evidenciaron que la respuesta contra APA de los enfermos fue significativamente mayor que la de los sanos vacunados, pero no se observaron diferencias significativas en este sentido entre los sanos no vacunados y los primeros. El método presentó una especificidad del 86 % y una sensibilidad del 39 %, por lo que la proteína APA recombinante evaluada tiene poco valor para el diagnóstico de la Tb en Cuba considerando que lo más importante dada la situación actual de reemergencia es la detección de los enfermos. El tiempo de tratamiento de los enfermos pudiera afectar la respuesta de anticuerpos contra APA, ya que se observó que el 89,4 % de estos individuos que fueron identificados como tal mediante este ensayo tenían menos de 60 d (d con medicación.

  9. Harmonization of Piece-by-Piece Measurement Methods of Roundwood Approved by Latvian Standard LVS 82:2003 “ Apaļo kokmateriālu uzmērīšana ”

    OpenAIRE

    Miklašēvičs, Ziedonis

    2015-01-01

    This paper analyses the volume differences of mixed pine and spruce roundwood loads and logs (roundwood assortiments) devided in to sample clusters according to the species, diameter, lenght and stem/log surface shape, stem zones and measured by the methods approved by standard LV 82:2003 „Apaļo kokmateriālu uzmērīšana”. The volumes of roundwood loads/logs determined by these methods were compared with the most precisious determination of the volume by Measuring Diameter in Short Intervals an...

  10. Construction of a visual determination method on the thickness and surface of APA Microcapsules by optica microscopy with frozen section and the ice emission scanning electron microscopy%采用冰冻切片和冷场发射电镜构建APA微囊的膜厚度及膜表面测定的方法研究

    Institute of Scientific and Technical Information of China (English)

    傅红兴; 李慧; 朱雁林; 赵应征; 吴岚岚; 江玲

    2013-01-01

    目的:建立一种APA微囊的膜厚度以及表面结构的检测方法,并测定微囊在湿状态的膜厚度和干燥后的膜表面结构.方法:采用亚甲蓝染色、冰冻切片结合光学显微镜观察微囊的膜厚度,并将囊膜在37℃孵育30 d后再次观察厚度的变化;对微囊进行冷冻干燥和冷场发射观察囊膜表面和断面结构.结果:APA-Ca和APA-Ba微囊的囊膜厚度并不均匀,孵育1个月后囊膜厚度变化差异无统计学意义(P>0.05);冷场发射扫描电镜下显示,两种微囊表面均光滑、致密;冻干后APA-Ca囊膜厚度达450 ~690 nm,而APA-Ba的囊膜厚度约为350 nm.结论:建立了一种简单、可靠的微囊膜厚度和表面检测方法,为进一步研究APA微囊的质量奠定了基础.%Objective: To explore a visual methold of the membrane thickness of APA microcapsules and their surface structures, and determinate the film thickness and surface characteristics. Methods: We use methyl-ene blue to dye the film of microcapsules, then within frozen section and optical microscope the the thickness of microcapsule were observed; and the thickness of microcapsules hatched in 37 ℃ for a month were also assayed. The surface of membrane were studied by ice emission scanning electron microscopy after lyophilization. Results: The member thickness of each APA microencapsules is not uniform. After incubated for 30 d in 37 ℃, there is no obviously difference in the thichness than befor (P>0.05). Surfaces of two microencapsules are smooth and compact under the scanning electron microscopy. The thickness of APA-Ca microcapsules are 450-690 nm, which of APA-Ba are about 350 nm. Conclusion: The essay provided a simple method on how to determine the membrane thickness and surface, which would be an important reference to expound the APA microcapsules.

  11. Comunicação ambiental: estratégias de mobilização socioparticipativa para educação, informação e integração da rede socioambiental APA SUL RMBH

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Andrade

    2010-01-01

    Full Text Available This article aims at introducing and analyzing communication models used in the socio-environmental network APA SUL RMBH, an environmentally sensitive area in which polemic issues and economicinterests are involved. These models provide inter-sectorial, participative, egalitarian and dynamic dialogues and information in order to put emphasis on the mobilization that characterizes the communicative process. The definition of common purposes, social actors and their roles, the active participation of all members of the community as well as the planning for more efficiency in the process reveal strategies of mobilization which structure themselves “with” and not “for” society. In this context, the usufruct and the consolidation of effective communication tools like, for example, permanent forums for debates, informational booklet, social research, training of local staff within a virtual and high-tech structuralmodel – Portal (or Site of the socio-environmental network APA SUL RMBH – have become a foundation for the convocation of common purposes and the establishment of social networks. Thus, the weaving and the crossing of these relationships outline an interconnected set of complementary factorsthat govern social mobilization in this socio-biodiversity area.

  12. Análise da riqueza da fauna de Braconidae (Hymenoptera, Ichneumonoidea em remanescentes naturais da Área de Proteção Ambiental (APA de Descalvado, SP

    Directory of Open Access Journals (Sweden)

    Cirelli Kátia Resende Netto

    2003-01-01

    Full Text Available Analysis of the Braconidae (Hymenoptera: Ichneumonoidea fauna richness in natural remnants of the Área de Proteção Ambiental (APA of Descalvado, SP. A survey of the Braconidae fauna on fragmentary natural environments at northeast São Paulo State was conducted using Malaise traps installed in five sites of Área de Proteção Ambiental of Descalvado. A total of 2,262 specimens, representing 22 subfamilies and 94 genera, was sampled throughout a period of sixteen months (from May, 1999 to August, 2000. Biological data were obtained from current literature and behavior patterns of host utilization for the studied fauna, mainly Braconidae which have been successful in control of agricultural insect pests. Statistical analyses indicated that the asymptote of the genera richness has been approached using this sampling method. This is the most complete survey yet available from natural fragmentary areas of the Descalvado Braconidae fauna. Patterns of distribution and richness of the Braconidae genera were established. Cluster Analysis was adopted taking as attribute the number of Braconidae genera.

  13. Citing Legal Material in APA Journals.

    Science.gov (United States)

    Osborne, Allan G., Jr.

    1992-01-01

    Guidelines are offered to authors on the correct citation format for legal references, including statutes and regulations, court decisions, and law review articles. Standards are based on those published by the Harvard Law Review Association and the American Psychological Association. (DB)

  14. Subjectivity NOT Statement and NOT APA!

    Science.gov (United States)

    Cihelkova, Dana

    2013-01-01

    I inspect in a brief theoretical-philosophical essay the roots of subjectivity and suggest many possible directions for examining the phenomenon of subjectivity so that multiple different meanings can be revealed. For instance, a researcher can explore her or his own subjectivity or he/she can attempt to define subjectivity per se or the…

  15. APA District Branch / State Association Directory

    Science.gov (United States)

    ... Health Sign In Join General Residents Medical Students International close menu Annual Meeting Psychiatrists Education Practice Cultural Competency Awards & Leadership Opportunities Advocacy & APAPAC Meetings Search Directories/Databases International ...

  16. 加筋沥青路面APA试验及其非线性疲劳损伤分析%APA TEST AND NONLINEAR FATIGUE DAMAGE ANALYSIS OF THE REINFORCED ASPHALT PAVEMENT

    Institute of Scientific and Technical Information of China (English)

    周志刚; 袁秀湘

    2012-01-01

    Wheel repeated loading test is carried out to the asphalt pavement specimen under several loading levels by using Asphalt Pavement Analyzer (APA) to compare the reinforcing effect of fabric and glassgrid on the fatigue characteristics of asphalt pavement. Based on this, one nonlinear fatigue damage model is suggested. By using fatigue damage mechanics-finite element method, the paper simulated numerically the total process of the APA test, and analyzed the stress, displacement and fatigue life of specimens. The comparison between the results of simulation and test proves the rationality of the suggested model. It is pointed out that using reinforcing material can remarkaeblely improve the stress and dispacement levels in pavement after the crack spreads across the reinforcement, and so to increase the pavement's fatigue life effectively due to the bridge effect of reinforcing materials. Besides, based on the fatigue analysis, it is proved further that Paris equation can be used to describe the spreading process of the fatigue crack in pavement, and related parameters can be obtained accordingly.%应用沥青路面分析仪(APA)对沥青路面结构模拟试件进行多种荷载下的往返轮载疲劳试验,对比研究土工布、玻璃纤维格栅对沥青路面疲劳性能的加筋效果。在此基础上,提出沥青混合料非线性疲劳损伤演化模型,应用基于疲劳损伤力学的非线性有限元方法模拟APA试验过程,分析了试件应力、变形、疲劳寿命等,并与试验结果对比,论证了所提疲劳损伤演化模型的合理性,指出因加筋材料的桥联效应显著地改善了裂缝穿过筋材后路面的受力变形状况,有效地延长路面的疲劳寿命。同时,基于疲劳损伤分析,进一步验证了Paris公式可用于描述路面结构的疲劳裂缝稳定发展过程,并获得了有关的参数。

  17. First evidence for expressive neoproterozoic intraplated mafic rocks and magma mixing in post-collisional A-PA type granites, Southern Brazil: Geochemistry and U-Pb (zircon), Nd-Sr-18O(zircon) isotope investigations

    International Nuclear Information System (INIS)

    New and recent geological investigations around Pien-Tijucas suture zone, between Luis Alves and Curitiba Microplates (Basei et al.2000) led to mapping of Palermo, Agudos do Sul and Rio Negro A-PA type Granites with expressive expositions of alkaline felsic ans mafic rocks and, associated mafic and felsic hybrid rocks. The suture zone is formed by subduction arc-related Pien-Mandirituba deformed calc-alkaline I-type granite belt and serpentinized supra subduction zone (SSZ) obducted mantle rocks with intrusive Neoproterozoic (650-630 Ma) very high Cr and Ni tholeitic gabbros. The Pien-Mandirituba calc-alkaline I-type Granite Belt is constituted by three main granite suites. The older emplaced pre-collisional suite is constituted by deformed to highly deformed amphibole and biotite-rich, magmatic epidote-absent quartz-monzodiorites and granodiorites formed between 620 and 610 Ma. The second sincollisional granite suite is constituted by deformed and slightly deformed low content amphibole-biotite-magmatic epidote-bearing, quartz-monzodiorites, granodiorites and leucogranodiorites emplaced between 605 and 595 Ma. The third, also sincollisional, granite suite is deformed to highly deformed biotite ± amphibole monzogranites. The deformation age of the three non-cogenetic granite suites of this granite belt is between 605-595 Ma. The granite rocks of the Pien-Mandirituba Granite Belt are meta-aluminous to slightly peraluminous, high K calc-alkaline, generally with high Ba, high Sr and low Rb contents. Palermo, Agudos do Sul and Rio Negro Granites are components of the expressive Neoproterozoic volcanic and plutonic alkaline-peralkaline Serra do Mar Suite (Kaul 1997), emplaced in extensional post-collisional and anorogenic settings along the central portion and northern border of the Luis Alves Microplate and southern border of the Curitiba Microplate. Magma mixing evidence is rare ou absent in the other components of the Serra do Mar volcanic and plutonic suite. The

  18. L'activité physique adaptée pour les personnes atteintes de diabète de type 2 : approche sociologique des "carrières de pratiquant d'APA" dans leurs relations avec la "trajectoire de maladie"

    OpenAIRE

    Barth, Nathalie

    2012-01-01

    Outre la prescription d’un traitement médicamenteux, la pratique régulière d’une Activité Physique Adaptée (APA)est recommandée aux personnes atteintes d’un diabète de type 2 (DT2), au même titre qu’un nouvel équilibre alimentaire(HAS, 2006). Cette incitation à opérer des changements concrets dans son « style de vie » rencontre des résistances, qui sontaccentuées pour les malades n’ayant pas préalablement construit de dispositions à la pratique physique. Des dispositifsinnovants ont été imagi...

  19. Spinal NO pathway takes part in the analgesic effect of APA microcapsulized BCCs subarachnoid transplantation%脊髓NO通路参与APA微囊化牛肾上腺嗜铬细胞蛛网膜下隙移植镇痛机理

    Institute of Scientific and Technical Information of China (English)

    徐龙河; 薛毅珑; 罗芸; 郭水龙; 张宏

    2004-01-01

    目的通过观察APA微囊化牛肾上腺嗜铬细胞(BCCs)移植对坐骨神经慢性挤压伤(CCI)大鼠脊髓神经元型一氧化氮合酶(Nnos)的影响,探讨脊髓NO通路是否参与APA微囊化BCCs蛛网膜下隙移植镇痛机理.方法 SD大鼠分为四组,每组5只,即对照组(C组),正常大鼠;CCI组,右侧坐骨神经结扎;APA组,CCI模型后1周,蛛网膜下隙移植500~600个APA空囊;APA-BCCs组,CCI模型后1周蛛网膜下隙移植5×106个APA微囊化BCCs.测定各组移植后1周的感觉异常和痛觉过敏阈值,感觉异常以Von Frey细丝触诱发痛阈值(g)表示,痛觉过敏阈值用CO2激光刺激痛阈值(ms)表示.动物处死后取脊髓冰冻切片,按照标准免疫组化法检测各组脊髓中Nnos的表达变化.结果 CCI组、APA组脊髓中Nnos活性较C组明显升高(P<0.01),但CCI组和APA组间无显著差异(P>0.05);APA-BCCs组结扎侧触诱发痛阈值和CO2痛阈值高于CCI组和APA组结扎侧(P<0.01),同时脊髓中Nnos活性较CCI组和APA组明显降低(P<0.01),与C组基本相同(P>0.05).结论 CCI大鼠脊髓Nnos表达增加,APA微囊化BCCs蛛网膜下隙移植缓解CCI大鼠的触诱发痛和痛觉过敏,同时降低CCI大鼠脊髓Nnos表达,提示脊髓NO通路参与APA微囊化BCCs蛛网膜下隙移植的镇痛作用.

  20. APA微囊化BCCs移植逆转神经性疼痛大鼠背根神经节Navl.8 mRNA表达下调%Reversion of down-regulated mRNA expression for Nav1.8 in dorsal root gangliaof rats with neuropathic pain by APA microcapsulized BCCs subarachnoid transplantation

    Institute of Scientific and Technical Information of China (English)

    徐龙河; 薛毅珑; 罗芸; 郭水龙; 张宏

    2004-01-01

    目的观察APA微囊化牛肾上腺嗜铬细胞(BCCs)移植对坐骨神经慢性挤压伤(CCI)大鼠背根神经节(DRG)Nav1.8 mRNA表达的影响.方法 SD大鼠分为4组,每组5只,即对照组(C组),正常大鼠;CCI组,右侧坐骨神经结扎;APA组,CCI模型后7 d,蛛网膜下腔移植500~600个APA空囊;APA-BCCs组,CCI模型后7 d蛛网膜下腔移植5×106个APA微囊化BCCs.测定各组移植前和移植后7d的触诱发痛阈值(g)和CO2激光刺激痛阈值(ms).移植后7 d行为学测定后取DRG冰冻切片,按照原位杂交法检测各组DRG中Nav1.8 mRNA表达的变化.结果 CCI组和APA组大鼠L4和L5 DRG Nav1.8杂交信号较C组明显降低(P<0.01),两组间差异无显著性(P>0.05).APA-BCCs组扎侧触诱发痛阈值和CO2痛阈值高于CCI组和APA组结扎侧(P<0.01),同时DRG中Nav1.8杂交信号较CCI组和APA组明显升高(P<0.01),于C组差异无显著性(P>0.05).结论 APA微囊化BCCs蛛网膜下腔移植可使CCI大鼠DRG中表达量下降的Nav1.8 mRNA恢复正常表达,APA微囊化BCCs蛛网膜下腔移植的镇痛作用和促进DRG中Nav1.8 mRNA表达恢复有关.

  1. What Is Psychiatry?

    Medline Plus

    Full Text Available ... APA Sites APA Publishing APA Learning Center APA Foundation APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental ... Medical Students International APA Sites APA Publishing APA Foundation APA Learning Center APA Annual Meeting Psychiatric News ...

  2. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Registration - Annual Meeting Advocacy & APAPAC APA Sites APA Publishing APA Learning Center APA Foundation APA Annual Meeting ... and Fellows Medical Students International APA Sites APA Publishing APA Foundation APA Learning Center APA Annual Meeting ...

  3. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Media Registration - Annual Meeting Advocacy & APAPAC APA Sites APA Publishing APA Learning Center APA Foundation APA Annual Meeting ... Residents and Fellows Medical Students International APA Sites APA Publishing APA Foundation APA Learning Center APA Annual Meeting ...

  4. Effect of P deficiency and Al stress on root tip of pigeon pea and the activities of acid phosphatase(APA) excreted from root tip%低磷与铝毒胁迫对木豆根尖及其分泌的酸性磷酸酶活性的影响

    Institute of Scientific and Technical Information of China (English)

    秦丽凤; 左方华; 段居琪; 玉永雄; 黎晓峰; 顾明华

    2006-01-01

    通过对木豆在低磷和铝毒胁迫下根尖内及根尖分泌的酸性磷酸酶(APA)活性的动态变化规律研究,旨在了解木豆对缺磷和铝胁迫的适应性机制,为木豆在酸性土壤上的栽培提供依据.结果表明:低磷(1μmol·L-1 P)使根尖内及根尖分泌的APA活性显著增加,并且低磷诱导根尖内APA活性增加早于根尖分泌的APA活性增加,在低磷胁迫的第7d,木豆根尖内APA活性达到最高,而根尖分泌的APA活性于第9d才达到最高.低磷引起的根尖及其分泌的APA活性增加在供磷24h后即显著降低,说明APA活性的增强是植物对低磷胁迫的适应性反应.另一方面,20μmol·L-1Al虽然使低磷胁迫下植株根尖内的APA活性显著降低,但根尖分泌的APA活性却有所增加,说明在低磷胁迫下铝引起根系分泌的APA活性增加可能是木豆适应酸性土壤逆境的重要机制.

  5. How to Use Current Medical Literature and APA Format Style.

    Science.gov (United States)

    Peek, Robin

    Directives and guidance in obtaining current medical literature are provided in this publication with special emphasis given to locating material in the Portland, Oregon area. The uses and types of periodical indexes are identified and periodical index citation examples are indicated. Explanations are offered on: (1) how to conduct an effective…

  6. Writing in APA Style: Faculty Perspectives of Competence and Importance

    Science.gov (United States)

    Landrum, R. Eric

    2013-01-01

    A US sample (N = 360) of psychology educators assessed 73 writing skills and competencies with regard to (a) the importance of each and (b) the typical performance of the top half of local psychology majors. An analysis of gap scores yielded results showing that specific skills, such as supporting claims with citations and proofreading ability,…

  7. Violence against Teachers: Case Studies from the APA Task Force

    Science.gov (United States)

    Reddy, Linda A.; Espelage, Dorothy; McMahon, Susan D.; Anderman, Eric M.; Lane, Kathleen Lynne; Brown, Veda Evanell; Reynolds, Cecil R.; Jones, Abraham; Kanrich, Jaclyn

    2013-01-01

    Violence directed toward teachers has been understudied despite significant media and empirical investigation on school violence, such as student-to-student victimization and bullying. To date, there are relatively few published studies scattered across many countries. To address this void, the American Psychological Association, in collaboration…

  8. Preparing Special Education Research Articles in APA Style.

    Science.gov (United States)

    Algozzine, Bob; Spooner, Fred; Karvonen, Meagan

    2002-01-01

    This article addresses key considerations in preparing special education research articles for submission to professional journals in which the preferred style guide is the "Publication Manual of the American Psychological Association." The guidelines are drawn from special education literature, from editors, and from authors experienced in…

  9. Putting the APA "Publication Manual" in Context. Commentary.

    Science.gov (United States)

    Russo, Nancy Felipe

    1999-01-01

    Explores feminist criticism of the "Publications Manual" of the American Psychological Association and the ways in which feminist researchers have negotiated changes in the language of this style guide. (SLD)

  10. Calcium carboorthovanadate - a new compound with the apa

    International Nuclear Information System (INIS)

    Data on calcium carboorthovanadate, Ca10(VO4)6CO3, a new compound with an appatite structure based on calcium orthovanadate, are reported. The synthesis has been conducted in a stoichiometric mixture of finely ground calcium carbonate and calcium orthovanadate. It is found that calcium carboorthovanadate belongs to the hexagonal syngony and has an apatite structure. An analysis of the infrared spectra of initial compounds and calcium carboorthovanadate confirmed the presence of carbonate (CO3)2- and orthovanadate (VO4)3 groupings in the latter. On heating in air, beginning with 450 deg C calcium carboorthovanadate decomposes at a slow rate into calcium oxide, calcium orthovanadate, and carbon dioxide

  11. Innovations in Academic Performance Audit (APA) to Empower Teaching & Learning: The Uniten Experience

    OpenAIRE

    Zainal Ariffin Ahmad; Norsalwati Binti Mohd Razalli

    2013-01-01

    Institutional audit is an integral part of the quality assurance process in the Malaysian higher education to determine whether the institution is achieving its mission and goals, to identify strengths and areas of concern, and to enhance quality. One form of institutional audit is the periodic academic performance audit to determine the continuation or maintenance of programme accreditation status. In 2011, UNITEN conducted an institutional audit (Academic Performance Audit) exercise to prep...

  12. Transport Research APAS (actions de preparation, d'accompagnement et du suivi)

    DEFF Research Database (Denmark)

    Leleur, Steen; Pedersen, Karsten S.; Bendtsen, Ulla

    1996-01-01

    The aim of the study, dealing with road investments evaluation, is to deliver a single, coherent approach of the full range of road projects. The study draws together, contrasts and compares evaluation procedures and fuses them into an approach to evaluation which embraces both technical performa...

  13. Health Service Providers in Psychology: Results of the 1978 APA Human Resources Survey.

    Science.gov (United States)

    Vandenbos, Gary R.; And Others

    1981-01-01

    Describes characteristics, employment setting, and professional practices of health service-provider psychologists. Discusses their current status in psychology, the distribution of health care practitioners, patterns of specialization in service delivery, and populations being served by these practitioners. (Author/MJL)

  14. Service Providers in Psychology: Results of the 1982 APA Human Resources Survey.

    Science.gov (United States)

    VandenBos, Gary R.; Stapp, Joy

    1983-01-01

    Based on a survey of service provider psychologists, describes (1) their age, sex, ethnicity, years since degree licensure, state association membership, and "National Register" listing; (2) primary and secondary employment settings; (3) professional practices; and (4) aspects of independent practice. (GC)

  15. Teaching Statistics in APA-Accredited Doctoral Programs in Clinical and Counseling Psychology: A Syllabi Review

    Science.gov (United States)

    Ord, Anna S.; Ripley, Jennifer S.; Hook, Joshua; Erspamer, Tiffany

    2016-01-01

    Although statistical methods and research design are crucial areas of competency for psychologists, few studies explore how statistics are taught across doctoral programs in psychology in the United States. The present study examined 153 American Psychological Association-accredited doctoral programs in clinical and counseling psychology and aimed…

  16. Too Many References, Just Cut a Few and It Will Be Perfect: APA vs. Chicago

    Science.gov (United States)

    Matusov, Eugene

    2011-01-01

    The purpose of the author's rebuttal is to provide a sociocultural critique of Wolff-Michael Roth and Michael Cole's arguments and of the current "Mind, Culture, and Activity" ("MCA") policy regarding referencing. In sum, Roth and Cole write that some unnamed "MCA" authors (and some scholars in general) abuse the reference practice by…

  17. In response to the 1998 APA Division 40 Presidential Address: so where's the beef?

    Science.gov (United States)

    Rodriguez-Menendez, G

    2000-05-01

    During the 1998 Division 40 presidential address by Linas Bieliauskas in San Francisco, several assertions were made contending that professional schools of psychology (PSP) had a deleterious effect on clinical neuropsychology by lowering professional standards, removing science from the curriculum, and producing mediocre clinicians. Bieliauskas reported to the author that he had based his opinion, in part, on data indicating that Boulder model graduates attained superior mean scores on the Examination for the Professional Practice in Psychology (EPPP) as compared to their Vail model counterparts. In order to determine whether significant differences existed between the two groups, a multivariate analysis of variance (MANOVA) was conducted using the 1997 EPPP scores reported by the Association of State and Provincial Psychology Boards (ASPPB, 1997). The author also provides a response to Bieliauskas' (1998) assertions. PMID:10916195

  18. Stereo Echo Cancellation(SEC) employing Signal Decorrelation with emphasis on Affine Projection Algorithm(APA)

    OpenAIRE

    Ande, Santosh

    2013-01-01

    Monophonic tele-conferencing systems employ acoustic echo cancellation (AEC) to reduce echoes that result from coupling between loudspeaker and microphone. Acoustic echo cancellation is simple to develope as there is a single channel. But future tele conferencing systems are expected to have multi channel communication which is necessary in hands-free multi user tele communication systems. Stereophonic echo cancellation (SEC), has been studied since the early 1990s, in hands-free tele communi...

  19. Of Course: Prerequisite Courses for Admission into APA-Accredited Clinical and Counseling Psychology Programs

    Science.gov (United States)

    Norcross, John C.; Sayette, Michael A.; Stratigis, Katerina Y.; Zimmerman, Barrett E.

    2014-01-01

    Students often inquire about which psychology courses to complete in preparation for graduate school. This study provides data that enable students and their advisors to make research-informed decisions. We surveyed the directors of the 304 American Psychological Association-accredited doctoral programs in clinical and counseling psychology (97%…

  20. Using the APA Guidelines for Psychotherapy with Lesbian, Gay, and Bisexual Clients in Education and Training.

    Science.gov (United States)

    Browning, Christine

    The American Psychological Association's adoption of the Guidelines for Psychotherapy with Lesbian, Gay, and Bisexual Clients has the potential to change the education and training approaches in psychology graduate programs and internship settings. Current research suggests that many graduate students do not receive adequate information about…

  1. The Model Does Matter II: Admissions and Training in APA-Accredited Counseling Psychology Programs

    Science.gov (United States)

    Norcross, John C.; Evans, Krystle L.; Ellis, Jeannette L.

    2010-01-01

    This study collected information on the acceptance rates, admission standards, financial assistance, student characteristics, theoretical orientations, and select outcomes of American Psychological Association-accredited counseling psychology programs (99% response rate). Results are presented collectively for all 66 counseling programs as well as…

  2. Workshops Increase Students' Proficiency at Identifying General and APA-Style Writing Errors

    Science.gov (United States)

    Jorgensen, Terrence D.; Marek, Pam

    2013-01-01

    To determine the effectiveness of 20- to 30-min workshops on recognition of errors in American Psychological Association-style writing, 58 introductory psychology students attended one of the three workshops (on grammar, mechanics, or references) and completed error recognition tests (pretest, initial posttest, and three follow-up tests). As a…

  3. The Fifth Edition of the APA "Publication Manual": Why Its Statistics Recommendations Are So Controversial.

    Science.gov (United States)

    Fidler, Fiona

    2002-01-01

    Identifies deficiencies in the new edition of the American Psychological Association's "Publication Manual," drawing on interviews with some critics and other parties. These include lack of follow-through with explanations and examples of how to report the statistics now recommended. (SLD)

  4. Guidelines for Nonsexist Language in APA Journals: Publication Manual Change Sheet 2

    Science.gov (United States)

    American Psychologist, 1977

    1977-01-01

    This second change sheet for its publication manual states the American Psychologist Association's policy on sexist language in its journals offers some general principles for journal authors to consider, and suggests some ways to avoid sexist language. (Author)

  5. Gentlemanly Orthodoxy: Critical Race Feminism, Whiteness Theory, and the APA Manual

    Science.gov (United States)

    Thompson, Audrey

    2004-01-01

    Although often viewed as burdensome, academic writing guidelines are rarely treated as actively problematic. Even progressive scholars are unlikely to challenge the cultural assumptions or political investments of academic style guides. Yet standards regarding clarity, precision, appropriateness, sensitivity, and objectivity are not politically…

  6. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Blogs Advocacy & APAPAC APA Sites APA Publishing APA Learning Center APA Foundation APA Annual Meeting Psychiatric News ... training then spends at least three additional years learning the diagnosis and treatment of mental health, including ...

  7. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Meeting Advocacy & APAPAC APA Sites APA Publishing APA Learning Center APA Foundation APA Annual Meeting Psychiatric News ... training then spends at least three additional years learning the diagnosis and treatment of mental health, including ...

  8. Exploring the APA Fifth Edition "Publication Manual"'s Impact on the Analytic Preferences of Journal Editorial Board Members.

    Science.gov (United States)

    Capraro, Mary Margaret; Capraro, Robert M.

    2003-01-01

    Studied the reporting preferences of editorial board members of four scholarly journals in education and psychology with regard to analytic practices in the fifth edition of the American Psychological Association "Publication Manual." Responses of 106 board members show the movement toward reform in research reporting practices. (SLD)

  9. What Is Psychiatry?

    Medline Plus

    Full Text Available ... and Fellows Medical Students International APA Sites APA Publishing APA ... © 2016 American Psychiatric Association. All Rights Reserved. 1000 Wilson Boulevard, Suite 1825, ...

  10. What Is Psychiatry?

    Medline Plus

    Full Text Available About APA APA's Vision, Mission, Values, and Goals Meet Our Organization Read APA Organization Documents and Policies Work at APA Contact Us Newsroom News Releases Message from ...

  11. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Contact Us Newsroom News Releases Message from the President Reporting on Mental Health Conditions APA Blogs Media ... APA Newsroom News Releases Psychiatric News Message from President APA Blogs Join APA General Members Residents and ...

  12. What Is Psychiatry?

    Medline Plus

    Full Text Available About APA APA's Vision, Mission, Values, and Goals Meet Our Organization Read APA Organization Documents and Policies Work at APA Contact Us Newsroom News Releases Message from the President Reporting on Mental Health Conditions ...

  13. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Releases Message from the President Reporting on Mental Health Conditions APA Blogs Advocacy & APAPAC APA Sites APA ... APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Sign In Join General Residents Medical Students International ...

  14. What Is Psychiatry?

    Medline Plus

    Full Text Available About APA APA's Vision, Mission, Values, and Goals Meet Our Organization Read APA Organization Documents and Policies Work at APA Contact Us Newsroom News Releases Message from the President Reporting on ...

  15. 基于膜分离过程的6-APA生产技术%Technology of Manufacturing 6-APA Based on Membrane Separation Process

    Institute of Scientific and Technical Information of China (English)

    何旭敏; 夏海平; 胡建华; 蓝伟光

    2002-01-01

    该项目设计了适当的纳滤膜浓缩工艺,以提高6-APA生成率,6-APA成品的平均克分子收率达90.18%;设计了醋酸丁酯-乙醇结晶工艺;选择了合适的溶媒体系及控制pH值以确保6-APA的质量;对溶媒及副产品苯乙酸进行了回收利用,降低了成本,减少了环境污染.纳滤膜分离技术是使低浓度裂解高浓度结晶得以实现的关键技术.用于100t 6-APA生产线上取得良好效果.

  16. 基于APA的沥青混合料水稳性试验研究%Experimental investigation of cement stability of bituminous mixture based on APA

    Institute of Scientific and Technical Information of China (English)

    李亿龙

    2007-01-01

    分析了几种评价沥青混合料水稳性的方法,比较了其特点以及存在的问题,通过对不同级配的沥青混合料进行APA浸水车辙试验,得出APA浸水车辙试验评价沥青混合料的水稳性能较好模拟实际路面发生水损害的结论.

  17. Applicability of Asphalt Pavement Analyzer APA%沥青路面分析仪APA的适用性评价

    Institute of Scientific and Technical Information of China (English)

    孙永军; 何锐

    2009-01-01

    指出沥青混凝土路面分析仪APA是一种以沥青混合料轮辙深度为主要评测指标的室内加速加载测试装置,通过对前人研究经验的总结,介绍了APA试验条件的确定过程,对其适用性进行了分析和总结,以推动国内关于APA在预测沥青混合料抗车辙性能方面的应用和研究.

  18. Probing the structure and dynamics of the RNA dinucleoside monophosphates (ApA, ApC, CpA, CpC) with NMR spectroscopy

    Czech Academy of Sciences Publication Activity Database

    Vokáčová, Zuzana; Schneider, Bohdan; Buděšínský, Miloš; Rosenberg, Ivan; Šponer, Jiří; Sychrovský, Vladimír

    Piechowice: -, 2008. L44. [Modeling & Design of Molecular Materials '08. 23.06.2008-28.06.2008, Piechowice] R&D Projects: GA AV ČR IAA400550701 Institutional research plan: CEZ:AV0Z40550506 Keywords : dinucleoside monophosphate * RNA * NMR Subject RIV: CF - Physical ; Theoretical Chemistry

  19. Probing the structure and dynamics of RNA dinucleoside monophosphates (ApA, ApC, CpA, CpC) with NMR spectroscopy

    Czech Academy of Sciences Publication Activity Database

    Vokáčová, Zuzana; Schneider, Bohdan; Buděšínský, Miloš; Rosenberg, Ivan; Sychrovský, Vladimír; Šponer, Jiří

    Sydney: World Association of Theoretical and Computational Chemists, 2008 - (Jordan, M.). s. 342-342 ISBN 978-0-646-50151-2. [WATOC 08. Congress of the World Association of Theoretical and Computational Chemists /8./. 14.09.2008-19..09.2008, Sydney] R&D Projects: GA AV ČR IAA400550701 Institutional research plan: CEZ:AV0Z40550506 Keywords : RNA * NMR Subject RIV: CF - Physical ; Theoretical Chemistry

  20. Probing the structure and dynamics of RNA dinucleoside monophosphates (ApA, ApC, CpA, CpC) with NMR spectroscopy

    Czech Academy of Sciences Publication Activity Database

    Vokáčová, Zuzana; Schneider, Bohdan; Bouř, Petr; Buděšínský, Miloš; Rosenberg, Ivan; Sychrovský, Vladimír

    Praha: Ústav fyzikální chemie J. Heyrovského AV ČR, 2008. PI-11. [Central European Symposium on Theoretical Chemistry /7./. 28.09.2008-01.10.2008, Hejnice] R&D Projects: GA MŠk LC512; GA ČR GA203/05/0388 Institutional research plan: CEZ:AV0Z40550506 Keywords : RNA * NMR Subject RIV: CF - Physical ; Theoretical Chemistry

  1. Apa l’Etrusco sbarca a Roma e passa il testimone ad Ati. Un cortometraggio tridimensionale per raccontare il santuario di Portonaccio a Veio

    Directory of Open Access Journals (Sweden)

    Alfonsina Russo

    2015-08-01

    Full Text Available Computer graphics movies are a favourite media for edutainment. The 3D stereoscopic short movie “Ati at the discovery of Veii” is an interesting example of philologically accurate reconstructions coupled with a communication aimed at a wide audience.  Developed by Cineca for a joint project involving the National Etruscan Museum of Villa Giulia and Genus Bononiae – Museum of the History of Bologna, the movie is grounded on the software Blender and a strong open source commitment.

  2. 77 FR 25717 - Proposed Issuance of a General NPDES Permit for Small Suction Dredging

    Science.gov (United States)

    2012-05-01

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... permits are permits, not rulemakings, under the APA and thus not subject to APA rulemaking requirements...

  3. 78 FR 17661 - Proposed Reissuance of a General NPDES Permit for Oil and Gas Exploration Facilities in the...

    Science.gov (United States)

    2013-03-22

    ... agency ``is required ] by section 553 of the Administrative Procedure Act (APA), or any other law, to..., under the APA and thus not subject to APA rulemaking requirements or the RFA. Notwithstanding...

  4. 75 FR 65483 - Proposed Reissuance of General NPDES Permits (GP) for Alaskan Medium-Size Suction Dredging...

    Science.gov (United States)

    2010-10-25

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... general permits are permits, not rulemakings, under the APA and thus not subject to APA...

  5. 78 FR 77122 - Proposed Modification of a General NPDES Permit for Small Suction Dredging-Permit Number IDG-37-0000

    Science.gov (United States)

    2013-12-20

    ... Procedure Act (APA), or any other law, to publish general notice of proposed rulemaking.'' The RFA exempts... permits are permits, not rulemakings, under the APA and thus not subject to APA rulemaking requirements...

  6. 28 CFR 42.208 - Notice of noncompliance.

    Science.gov (United States)

    2010-07-01

    ... Act (APA) if: (1) The agency gives all interested parties opportunity for— (i) The submission and... consistent with the APA, it shall presume the APA procedures were applied, and send notification under §...

  7. What Is Psychiatry?

    Medline Plus

    Full Text Available ... APA's Vision, Mission, Values, and Goals Meet Our Organization Read APA Organization Documents and Policies Work at APA Contact Us ... has an advanced degree, most commonly in clinical psychology, and often has extensive training in research or ...

  8. Warning Signs of Mental Illnesses

    Science.gov (United States)

    ... Illness What Is Psychiatry? What Is Mental Illness? Suicide Prevention What is ECT? Ask An Expert Share Your Story Become an APA Member Learn More Explore APA Psychiatrists Residents & Medical Students Patients & Families About APA Newsroom News Releases Psychiatric ...

  9. How Planners Deal with Uncomfortable Knowledge: The Dubious Ethics of the American Planning Association

    OpenAIRE

    Bent Flyvbjerg

    2013-01-01

    With a point of departure in the concept "uncomfortable knowledge," this article presents a case study of how the American Planning Association (APA) deals with such knowledge. APA was found to actively suppress publicity of malpractice concerns and bad planning in order to sustain a boosterish image of planning. In the process, APA appeared to disregard and violate APA's own Code of Ethics. APA justified its actions with a need to protect APA members' interests, seen as preventing planning a...

  10. 24 CFR 3280.304 - Materials.

    Science.gov (United States)

    2010-04-01

    ... APA Trademarks)—PS 1-95. APA Design/Construction Guide, Residential and Commercial—APA E30-P-1996...-Plywood Beams—APA H-815E (PDS Supplement #5), 1995. Panel Design Specification—APA D410A, 2004. Design and Fabrication of Glued Plywood-Lumber Beams—APA-S 812Q, Suppl. 2-1992. Design and Fabrication of Plywood...

  11. 75 FR 2785 - Naturalization for Certain Persons in the U.S. Armed Forces

    Science.gov (United States)

    2010-01-19

    ... Procedure Act The Administrative Procedure Act (APA) provides that an agency may dispense with notice and... exempt from the notice and comment requirements under the APA at 5 U.S.C. 553(b)(A). The APA provides... and comment requirements under the APA at 5 U.S.C. 553(b)(B). B. Regulatory Flexibility Act...

  12. 42 CFR 137.309 - How are NEPA and NHPA obligations typically enforced?

    Science.gov (United States)

    2010-10-01

    ... may only be filed in Federal court under the provisions of the APA, 5 U.S.C. 701-706. Under the APA, a... the court's views for those of the agency. Jury trials and civil discovery are not permitted in APA... injunctive relief to the interested party. No money damages or fines are permitted in APA proceedings....

  13. 26 CFR 1.6038A-3 - Record maintenance.

    Science.gov (United States)

    2010-04-01

    ... maintenance requirement to particular documents. (4) Agreement as part of APA process. An agreement with a... Agreement (APA) process at any time during the APA process, insofar as the agreement relates to the subject matter of the APA. (f) U.S. maintenance—(1) General rule. Records that must be maintained under...

  14. Protein (Viridiplantae): 303283426 [PGDBj - Ortholog DB

    Lifescience Database Archive (English)

    Full Text Available EQLADPLVLVGGFVCGIPEDAFLAGVACASPAPVVVELPSSPPPPPPGLPPQPEAPAASPPPPGAPPTSVEPPPEPEAPPAPDALSPPPPRAPPEPVAASPPPSPAPPPPERPPTPVVAPSPA...QIEDAANYKGDPLNDGTELLVDSAEACCNVCHRFNGCNSFVYCAGEDGCYSDYYLYKHRECWLKWLAPDLYEQFPPPAWARGDDAMNWTSGLVNRTACAPGAEVPLPAPVASPPPAPLVTEAPAPAPAPAPA...TATEKNHADATPRASGSWSAPRTHAISLARGDAAATTVARSDASPDAIRIDTPRRSLQDGVATVPPPTAAAADADAGAAAAAAAAAACADLANGALKFSVTTWTSLP...AAFTPMACGFTIKTGDVCTDMRALETFITNEREDLSDEPVASVEVLISEGGALDVSLPCDDQVEAAAAMCQRLTRVTPGPAPLVTDY...PSLLDMVFHSVIPAVDEDDTALTQASGVVGHRSCATMDVTGVTVPVPYAETVDPASFEVTCEGAQLAWPLESFRAGGAMKRPAAPLSCDDLDLVM

  15. The Anti-Inflammatory Actions of Auricular Point Acupressure for Chronic Low Back Pain

    OpenAIRE

    Wei-Chun Lin; Chao Hsing Yeh; Lung-Chang Chien; Morone, Natalia E.; Glick, Ronald M.; Albers, Kathryn M.

    2015-01-01

    Background. Auricular point acupressure (APA) is a promising treatment for pain management. Few studies have investigated the physiological mechanisms of APA analgesics. Method. In this pilot randomized clinical trial (RCT), a 4-week APA treatment was used to manage chronic low back pain (CLBP). Sixty-one participants were randomized into a real APA group (n = 32) or a sham APA group (n = 29). Blood samples, pain intensity, and physical function were collected at baseline and after 4 weeks of...

  16. The Incidence and Anatomy of Accessory Pudendal Arteries as Depicted on Multidetector-Row CT Angiography: Clinical Implications of Preoperative Evaluation for Laparoscopic and Robot-Assisted Radical Prostatectomy

    International Nuclear Information System (INIS)

    To help preserve accessory pudendal arteries (APAs) and to ensure optimal postoperative sexual function after a laparoscopic or robot-assisted radical prostatectomy, we have evaluated the incidence of APAs as detected on multidetector-row CT (MDCT) angiography and have provided a detailed anatomical description. The distribution of APAs was evaluated in 121 consecutive male patients between February 2006 and July 2007 who underwent 64- channel MDCT angiography of the lower extremities. We defined an APA as any artery located within the periprostatic region running parallel to the dorsal vascular complex. We also subclassified APAs into lateral and apical APAs. Two radiologists retrospectively evaluated the origin, course and number of APAs; the final APA subclassification based on MDCT angiography source data was determined by consensus. We identified 44 APAs in 36 of 121 patients (30%). Two distinct varieties of APAs were identified. Thirty-three APAs (75%) coursed near the anterolateral region of the prostatic apex, termed apical APAs. The remaining 11 APAs (25%) coursed along the lateral aspect of the prostate, termed lateral APAs. All APAs originated from the internal obturator artery and iliac artery or a branch of the iliac artery such as the inferior vesical artery. The majority of apical APAs arose from the internal obturator artery (84%). Seven patients (19%) had multiple APAs. APAs are more frequently detected by the use of MDCT angiography than as suggested by previous surgical studies. The identification of APAs on MDCT angiography may provide useful information for the surgical preservation of APAs during a laparoscopic or robot-assisted radical prostatectomy

  17. Comments on the BfS draft report: comparative options evaluation - preliminary status: Step 1 - technical evaluation of the decommissioning options for the final repository for radioactive wastes Asse''. Status 25.11.2009 (AP-A7)

    International Nuclear Information System (INIS)

    The comments on the BfS draft report: comparative options evaluation - preliminary status of Step 1 - technical evaluation of the decommissioning options for the final repository for radioactive wastes Asse'' (status 25.11.2009) cover the following topics: Safety in the operational phase; environmental impacts in case of an uncontrollable brine intrusion; preliminary long-term safety assessment; feasibility; time required.

  18. Revisión acerca de las normas para la presentación de referencias bibliográficas según el estilo de la American Psychological Association (APA

    Directory of Open Access Journals (Sweden)

    Cristian Carlos Abalos

    2003-01-01

    Full Text Available Numerosas instituciones han hecho accesibles sus datos a través de la infraestructura de comunicaciones que ofrece la internet, a través de la World Wide Web. Su amplia versatilidad permite trabajar con ficheros de texto, sonido, imágenes fijas y/o en movimiento, así como la capacidad de acceder desde ella a todos los otros servicios de internet. Bajo este esquema tecnológico surgieron los distintos recursos electrónicos de información. Para la preparación de un informe en los ámbitos académicos y científicos, cada día es más necesario citar y referirse a documentos e información obtenida a través de medios electrónicos. La utilización de estos recursos hace necesario contar con un sistema que determine un criterio adecuado para citarlos. En este artículo, se presenta una síntesis del estilo sugerido por la American Psychological Association para citar documentos electrónicos consultados a través de la internet.

  19. Revisión acerca de las normas para la presentación de referencias bibliográficas según el estilo de la American Psychological Association (APA)

    OpenAIRE

    Cristian Carlos Abalos

    2003-01-01

    Numerosas instituciones han hecho accesibles sus datos a través de la infraestructura de comunicaciones que ofrece la internet, a través de la World Wide Web. Su amplia versatilidad permite trabajar con ficheros de texto, sonido, imágenes fijas y/o en movimiento, así como la capacidad de acceder desde ella a todos los otros servicios de internet. Bajo este esquema tecnológico surgieron los distintos recursos electrónicos de información. Para la preparación de un inform...

  20. The Parallel SM- APA Algorithm for Solving Eigenvalue Problem of Symmetric Matrices%解对称矩阵特征值问题的并行SM-APA算法

    Institute of Scientific and Technical Information of China (English)

    崔向照

    2004-01-01

    在二分法和APA算法的基础上,给出了一种求实对称矩阵特征值问题的并行SM-APA算法,理论分析和在PVM下的数值结果表明,我们的算法比二分法快,而且有较高的加速比.

  1. CASS-SBR工艺在6-APA生产废水处理中的应用%The Application of CASS-SBR Process to Treating 6-APA Wastewater

    Institute of Scientific and Technical Information of China (English)

    万红

    2005-01-01

    介绍了CASS-SBR法处理6-APA生产废水的工程实例,这种处理方法是对传统SBR法的一种改进,具有流程简洁、占地面积少、处理效率高、出水水质稳定、运行时间短等优点.实际运行结果表明:处理出水能够满足排放标准要求.

  2. 英语论文MLA与APA格式中参考书目格式的异同比较%The Differences Between MLA Format and APA Format of References in English Paper

    Institute of Scientific and Technical Information of China (English)

    罗海艳

    2008-01-01

    对英语论文MLA与APA格式中参考书目的格式进行了比较,列举了五个方面的相同点,用例子从十个方面分析比较了不同点,目的是促进国内作者对英语论文参考书目格式的书写规范.

  3. Survey of vegetation and its diametric distribution in an area of cerrado sensu stricto and riparian forest fragment at Dois Irmãos stream in the Area of Environmental Protection (APA of Cafuringa, Federal District, Brazil.

    Directory of Open Access Journals (Sweden)

    José Elias de Paula

    2009-09-01

    Full Text Available All individual trees with a diameter at breast height (DBH of over 5cm, as well as the natural succession, were identified in 2,500m2 of the savannah (cerrado sensu stricto area and in 5,000m2 of the “Dois Irmãos” riparian forest vegetation (15º30’19”S and 48º06’18”W. The floristic composition of the cerrado sensu stricto was composed by 100 trees distributed in 25 species, and the riparian forest consisted of 155 trees distributed in 55 species. The natural regeneration was formed with 211 and 287 individuals in the cerrado sensu stricto and riparian forest distributed into 38 and 55 species respectively. The basal areas of the trees occupied 3.40m2.ha-1 in the cerrado sensu stricto and 5.08m2.ha-1 in the riparian forest. The diametric distribution curves for both plant communities, adjusted by the Meyers equation, demonstrated a typical tendency of reversed-J shape with strongly antropic action in the 11 to 17cm diametric classes.

  4. Structure and dynamics of the ApA, ApC, CpA and CpC RNA dinucleoside monophosphates resolved with NMR scalar spin-spin couplings

    Czech Academy of Sciences Publication Activity Database

    Vokáčová, Zuzana; Schneider, Bohdan; Buděšínský, Miloš; Rosenberg, Ivan; Šponer, Jiří; Sychrovský, Vladimír

    2009-01-01

    Roč. 16, 1a (2009), b52-b52. ISSN 1211-5894. [Meeting of the Czechoslovak and Slovak Biologists /7./. 12.03.2009-14.03.2009, Nové Hrady] R&D Projects: GA AV ČR IAA400550701 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50040507 Keywords : NMR * dinucleoside monophosphate Subject RIV: CF - Physical ; Theoretical Chemistry

  5. Structure and dynamics of the ApA, ApC, CpA and CpC RNA dinucleoside monophosphates resolved with NMR scalar spin-spin couplings

    Czech Academy of Sciences Publication Activity Database

    Vokáčová, Zuzana; Buděšínský, Miloš; Rosenberg, Ivan; Schneider, Bohdan; Šponer, Jiří; Sychrovský, Vladimír

    2009-01-01

    Roč. 113, č. 4 (2009), s. 1182-1191. ISSN 1520-6106 R&D Projects: GA AV ČR IAA400550701 Institutional research plan: CEZ:AV0Z40550506; CEZ:AV0Z50040507; CEZ:AV0Z50520701 Keywords : RNA * NMR * MD Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.471, year: 2009

  6. El artículo científico para revista académica: Pautas para su planificación y edición de acuerdo con el modelo APA

    Directory of Open Access Journals (Sweden)

    María Elena Camacho Villalobos

    2014-07-01

    Full Text Available A partir de la experiencia de las autoras como directoras y editoras de revistas académicas, en comités editoriales, en arbitrajes de textos, en cursos impartidos para la redacción de artículos y sobre la escritura en general, y en la revisión filológica, se propone este artículo. En estas experiencias han detectado diversas dificultades en la escritura de artículos, por lo cual plantean los indicadores de calidad e información pertinente para la escogencia del medio en que se quiere publicar; formato general, modalidades y partes constituyentes del artículo; la construcción de la cohesión y la coherencia; la planificación del texto y la elaboración de las paráfrasis. Bosquejan elementos que se deben revisar antes de enviar el artículo, así como estrategias para gestionar la publicación en la revista. Con ello, atienden detalles que tienen que ver con un asunto pragmático y formal. La síntesis y el análisis constituyen herramientas para la elaboración de la paráfrasis, por tanto, su abordaje se ha considerado relevante debido a que facilitan el acopio de información de diversas fuentes y su adecuado empleo en el documento propio. Recalcan la noción de que escribir es un acto comunicativo en el cual se debe colaborar con los potenciales lectores o lectoras con un texto cohesionado, coherente, conciso y claro. Este constituye una propuesta de lingüística aplicada a la construcción del texto académico, de provecho para diversas disciplinas.

  7. 基于APAS影像分析的篮球中距离跳投技术分析研究%Technique Analysis of Basketball Mid Distance Jump Shot Based on APAS Image

    Institute of Scientific and Technical Information of China (English)

    樊六东; 丁洪福

    2011-01-01

    跳投是现代篮球用的最多的投篮方式,本研究用摄影机以6 0 HZ抓取中国矿业大学男子篮球队参加过2005-2009年CUBA比赛中司职前锋及后卫的10名队员为研究对象,实验利用队员在罚球线位置做中距离跳投影像为基础,通过ArielPerformance Analysis System(APAS)进行2 D动作分析,并对收集的各分期占动作时间比例、球离手时机、球离手角度与命中率等运动学参数以叙述统计、单因子变异数分析、皮尔逊积差相关进行了统计分析,研究结论为篮球中距离跳投技术的训练与研究打下了一定基础。%Jumper shot is the most widely shooting used by basketball players.Two-dimensional video techniques(6 0 HZ)were used to obtain images of basketball jump shots from free throw line(n=10),as performed by 10 players of China University of Mining men's basketball team participated in the 2005-2009 competition of the functional CUBA striker and defender.The collected data were analyzed by one-way ANOVA and person product-moment correlation.A mid-range jump shot basketball skills training and research laid has come to conclusion.

  8. El artículo científico para revista académica: Pautas para su planificación y edición de acuerdo con el modelo APA

    OpenAIRE

    María Elena Camacho Villalobos; Marta Eugenia Rojas Porras; Lillyam Rojas Blanco

    2014-01-01

    A partir de la experiencia de las autoras como directoras y editoras de revistas académicas, en comités editoriales, en arbitrajes de textos, en cursos impartidos para la redacción de artículos y sobre la escritura en general, y en la revisión filológica, se propone este artículo. En estas experiencias han detectado diversas dificultades en la escritura de artículos, por lo cual plantean los indicadores de calidad e información pertinente para la escogencia del medio en que se quiere publicar...

  9. Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma

    OpenAIRE

    Kishimoto, Rui; Oki, Kenji; Yoneda, Masayasu; Gomez-Sanchez, Celso E.; Ohno, Haruya; Kobuke, Kazuhiro; Itcho, Kiyotaka; Kohno, Nobuoki

    2016-01-01

    Abstract We aimed to detect novel genes associated with G protein-coupled receptors (GPCRs) in aldosterone-producing adenoma (APA) and elucidate the mechanisms underlying aldosterone production. Microarray analysis targeting GPCR-associated genes was conducted using APA without known mutations (APA-WT) samples (n = 3) and APA with the KCNJ5 mutation (APA-KCNJ5; n = 3). Since gonadotropin-releasing hormone receptor (GNRHR) was the highest expression in APA-WT by microarray analysis, we investi...

  10. US guidelines for treatment of schizophrenia expected next year.

    OpenAIRE

    Johnston, C

    1995-01-01

    The American Psychiatric Association (APA) is developing new guidelines for treating schizophrenia. The recommendations, which were previewed at the APA's annual meeting earlier this year, are expected to be released in 1996.

  11. Learn to manage your anger

    Science.gov (United States)

    ... Controlling Your Anger Before it Controls You. www.apa.org/topics/anger/control.aspx . Accessed September 18, ... Psychologist Can Help You Manage Your Anger. www.apa.org/topics/anger/help.aspx . Accessed April 28, ...

  12. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Releases Message from the President Reporting on Mental Health Conditions APA Blogs Media Registration - Annual Meeting Advocacy & ... APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Sign In Join General Residents Medical Students International ...

  13. Subcellular RNA profiling links splicing and nuclear DICER1 to alternative cleavage and polyadenylation

    OpenAIRE

    Furger, AM; Neve, J; Burger, K; Patel, R.; Gullerova, M; Li, W.; Hoque, M.; Tian, B.

    2015-01-01

    Alternative cleavage and polyadenylation (APA) plays a crucial role in the regulation of gene expression across eukaryotes. Although APA is extensively studied, its regulation within cellular compartments and its physiological impact remains largely enigmatic. Here, we employed a rigorous subcellular fractionation approach to compare APA profiles of cytoplasmic and nuclear RNA fractions from human cell lines. This approach allowed us to extract APA isoforms that are subjected t...

  14. Microarray Meta-Analysis of RNA-Binding Protein Functions in Alternative Polyadenylation

    OpenAIRE

    Hu, Wenchao; Liu, Yuting; Yan, Jun

    2014-01-01

    Alternative polyadenylation (APA) is a post-transcriptional mechanism to generate diverse mRNA transcripts with different 3′UTRs from the same gene. In this study, we systematically searched for the APA events with differential expression in public mouse microarray data. Hundreds of genes with over-represented differential APA events and the corresponding experiments were identified. We further revealed that global APA differential expression occurred prevalently in tissues such as brain comp...

  15. Anticipatory and compensatory postural adjustments in people with low back pain: a protocol for a systematic review and meta-analysis

    OpenAIRE

    Knox, Michael F.; Chipchase, Lucy S; Schabrun, Siobhan M.; Paul W M Marshall

    2016-01-01

    Background Anticipatory (APAs) and compensatory (CPAs) postural adjustments are organised by the central nervous system (CNS) and serve to control postural perturbations. Ineffective APAs and CPAs have been hypothesised to contribute to the persistence of symptoms and disability in people with low back pain (LBP). Despite two decades of research, there is no systematic review investigating APAs and CPAs in people with LBP. Thus, the aim of the current review is to determine if APA and CPA ons...

  16. Reports to the Membership.

    Science.gov (United States)

    2016-07-01

    The following are edited/abbreviated versions of the annual reports of the APA Secretary, Treasurer, CEO and Medical Director, Speaker, and Speaker-Elect and the chairpersons of the APA Committee on Bylaws, Membership Committee, Committee of Tellers, and Elections Committee. The full reports were presented at the APA Annual Business Meeting in Atlanta, May 15th, 2016. PMID:27363564

  17. Antropologi dan Jaringannya di Indonesia

    OpenAIRE

    Jonris G. Purba

    2009-01-01

    Jika melihat tulisan ini sepintas dari judulnya, maka kita akan bertanya mengapa antropologi mempunyai jaringan. Di samping itu kita juga akan bertanya: jaringan seperti apa yang ada dalam antropologi itu? Bagaimana terbentuknya jaringan itu? Dan apa yang menjadi latar belakang munculnya jaringan antropologi tersebut? Serta apa saja manfaat dan kegiatan yang dilaksanakan dalam jaringan tersebut? ker-jul2006- (3)

  18. 78 FR 77563 - Technical Amendments

    Science.gov (United States)

    2013-12-24

    ... Stat. 857 (1996). \\5\\ 5 U.S.C. 551. Final Rule Generally, the Administrative Procedure Act (APA... reflect the conversion to the CAMEL rating system for corporate credit unions. The APA permits an agency... under section 553(b)(3)(B) of the APA.\\6\\ NCUA also finds good cause to dispense with the 30-day...

  19. Alternative polyadenylation: New insights from global analyses

    OpenAIRE

    Shi, Yongsheng

    2012-01-01

    Recent global studies revealed that mRNA alternative polyadenylation (APA) is widespread in eukaryotic transcriptomes and is an important mechanism for gene regulation. APA deregulation has been found in a variety of diseases. This article reviews recent progress in the field and provides a global perspective on the prevalence, mechanisms, and functional impact of APA.

  20. On linear isometries on non-archimedean powerseries spaces

    OpenAIRE

    Śliwa, Wiesław; Ziemkowska, Agnieszka

    2012-01-01

    The non-archimedean power series spaces Ap(a; t) are the most known and important examples of non-archimedean nuclear Frechet spaces. We study when the spaces Ap(a; t) and Aq(b; s) are isometrically isomorphic. Next we determine all linear isometries on the space Ap(a; t) and show that all these maps are surjective.

  1. 78 FR 49555 - Special Opportunities Fund, Inc.; Notice of Application

    Science.gov (United States)

    2013-08-14

    ... Section 554(e) of the Administrative Procedure Act of 1946 (``APA'') concerning a proxy voting procedure... order under Section 554(e) of the APA declaring that applicant's proxy voting procedure does not satisfy... declaratory order pursuant to Section 554(e) of the APA stating that the Voting Procedure ``does not cause...

  2. 75 FR 78900 - Regulations Governing Book-Entry Treasury Bonds, Notes and Bills Held in Legacy Treasury Direct...

    Science.gov (United States)

    2010-12-17

    ... pursuant to Executive Order 12866. Administrative Procedure Act (APA). Because this rule relates to United... within the contract exception to the APA, 5 U.S.C. 553(a)(2). As a result, the notice, public comment, and delayed effective date provisions of the APA are inapplicable to this rule. Regulatory...

  3. 78 FR 12998 - Establishment of Due Process Procedures on License-Like Processes

    Science.gov (United States)

    2013-02-26

    ... Procedure Act (APA) if their entry filer code is deactivated. Lizarraga, at 16. As such, CBP has reviewed... procedures required by the APA if an importer's or broker's assigned entry filer code is proposed to be suspended or revoked. The APA (Section 558 of title 5 of the United States Code) provides, in relevant...

  4. 78 FR 60766 - Clarification on Fireworks Policy Regarding Approvals or Certifications for Specialty Fireworks...

    Science.gov (United States)

    2013-10-02

    ... requirements in the APA Standard 87-1, and pass a thermal stability test. Instead of applying to PHMSA, the manufacturer may apply in writing to an FCA with the information required in the APA Standard 87-1. After....64 or 173.65, the APA Standard 87-1 and the requirements below. \\2\\ An example of a...

  5. 78 FR 20316 - Final Issuance of General NPDES Permits (GP) for Small Suction Dredges in Idaho

    Science.gov (United States)

    2013-04-04

    ... required by section 553 of the Administrative Procedure Act (APA), or any other law, to publish general... entities.'' EPA has concluded that NPDES general permits are permits, not rulemakings, under the APA and thus not subject to APA rulemaking requirements or the RFA. Notwithstanding that general permits...

  6. Cross-Cultural Variations in Big Five Relationships with Religiosity: A Socio-Cultural Motives Perspective

    OpenAIRE

    Gebauer, Jochen E.; Bleidorn, Wiebke; Samuel D. Gosling; Rentfrow, Peter J.; Lamb, Michael E.; Potter, Jeff

    2014-01-01

    This is the accepted manuscript. This article may not exactly replicate the final version published in the APA journal. It is not the copy of record. The final version is available from APA at http://psycnet.apa.org/psycinfo/2014-35855-001/.

  7. Ensuring the Availability and Quality of School Psychology Doctoral Internships

    Science.gov (United States)

    Harris, Abigail M.

    2015-01-01

    Currently, only a small percentage of internships accredited by the American Psychological Association (APA) are filled by school psychology interns and only a few of the available APA internship positions are in schools. Program data submitted online to APA indicate that many interns are in sites that meet the guidelines adopted by the Council of…

  8. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Illness What Is Psychiatry? What Is Mental Illness? Suicide Prevention What is ECT? Ask An Expert Share Your Story Become an APA Member Learn More Explore APA Psychiatrists Residents & Medical Students Patients & Families About APA Newsroom News Releases Psychiatric ...

  9. 2010 Annual Report of the American Psychological Association

    Science.gov (United States)

    American Psychologist, 2011

    2011-01-01

    This report presents the 2010 annual report of the American Psychological Association (APA). It provides the highlights of the association's and individual directorate's activities to APA members. APA continued its efforts to advance psychological practice and ensure the public's access to high-quality psychological services, apply psychological…

  10. Variation of Alkaline Phosphatase Activity in Sediments of Shrimp Culture Ponds and Its Relationship with the Contents of C, N and P

    Institute of Scientific and Technical Information of China (English)

    SU Yuepeng; MA Shen; DONG Shuanglin

    2005-01-01

    Nine enclosures (5 m × 5 m) were built in a Fenneropenaeus chinensis culture pond of Rushan Gulf in April, 2001.The probiotics and BIO ENERGIZER solution were applied for disparate treatments. Variations of alkaline phosphatase activity (APA) and its relationship with the contents of C, N and P in sediments were studied. Results show that APA of sediments increases from 3.096 nmol g-1min-1 to 5.407 nmol g-1nin-1 in culture period; the bacteria biomass is not the only factor to determine APA; the contents of total P and total organic carbon have a significant positive correlation with APA, while that of total nitrogen has a negative correlation. In addition, the contents of inorganic P and organic P are not regular with APA. By comparison, TOC shows a more significant coherence with APA, meaning that organic pollution in sediments affects APA remarkably.

  11. The Anti-Inflammatory Actions of Auricular Point Acupressure for Chronic Low Back Pain.

    Science.gov (United States)

    Lin, Wei-Chun; Yeh, Chao Hsing; Chien, Lung-Chang; Morone, Natalia E; Glick, Ronald M; Albers, Kathryn M

    2015-01-01

    Background. Auricular point acupressure (APA) is a promising treatment for pain management. Few studies have investigated the physiological mechanisms of APA analgesics. Method. In this pilot randomized clinical trial (RCT), a 4-week APA treatment was used to manage chronic low back pain (CLBP). Sixty-one participants were randomized into a real APA group (n = 32) or a sham APA group (n = 29). Blood samples, pain intensity, and physical function were collected at baseline and after 4 weeks of treatment. Results. Subjects in the real APA group reported a 56% reduction of pain intensity and a 26% improvement in physical function. Serum blood samples showed (1) a decrease in IL-1β, IL-2, IL-6, and calcitonin gene-related peptide [CGRP] and (2) an increase in IL-4. In contrast, subjects in the sham APA group (1) reported a 9% reduction in pain and a 2% improvement in physical function and (2) exhibited minimal changes of inflammatory cytokines and neuropeptides. Statistically significant differences in IL-4 and CGRP expression between the real and sham APA groups were verified. Conclusion. These findings suggest that APA treatment affects pain intensity through modulation of the immune system, as reflected by APA-induced changes in serum inflammatory cytokine and neuropeptide levels. PMID:26170869

  12. The Selection of Ways to Advance Pricing System in China Thinking after Signing the First China-South Korea Bilateral APA%我国预约定价制度的路径选择——中韩首例双边预约定价安排的签署引发的思考

    Institute of Scientific and Technical Information of China (English)

    刘伟

    2009-01-01

    我国自1998年首次引入预约定价制度,十年来虽然历经修改与补充,但仍然处于起步和探索阶段.具体表现为:法律层级偏低、具体规定上不够完整和合理、某些政策空白点导致无法可依、相应的配套措施及管理能力滞后,等等.因此,我国应针对问题找出应对的措施,以期我国的预约定价制度向更新、更深的方向发展.

  13. Research on the market availability of mining machines with specific features (radiation protection, remote handling equipment, electric power drive) for the radioactive waste retrieval; Recherche zur Marktverfuegbarkeit von Bergbaumaschinen mit speziellen Eigenschaften (Strahlenschutz, Fernbedienung, Elektroantrieb) zur Rueckholung der radioaktiven Abfaelle aus der Asse (AP-A14)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-12

    The report has been prepared in the frame of the required fact assessment process concerning the state of the waste packages in the emplacement cabins of the Schachtanlage Asse. The search on the market availability of mining machines with specific features (radiation protection, remote handling equipment, electric power drive) for the radioactive waste retrieval covered the following issues: gangue exploitation and room-and-pillar work, underground hauling and transport, railless special vehicles for underground transportation, continuous conveyors and components, feeding and removal equipment, control techniques communication and navigation. The report includes a summary of results and open questions.

  14. "I Hate Video Games":从舆论到医学——美国精神病学会欲将游戏瘾列入精神病%'I hate video games' : from the Public Voice to Medicine-APA is Going to Add Vedio Game Addiction into the List of Mental Disorders

    Institute of Scientific and Technical Information of China (English)

    薛伟; 陈其庆

    2008-01-01

    @@ 对于绝大多数视频游戏玩家而言,游戏仅仅是游戏.它是一种以高科技手段来打发时间、尽情欢乐、在虚拟世界中一展身手的途径.然而,对于越来越多的超级游戏迷而言,则要严重得多--已经到了难以将现实和游戏分开的程度.

  15. Changes in Sleep With Auricular Point Acupressure for Chronic Low Back Pain.

    Science.gov (United States)

    Yeh, Chao Hsing; Suen, Lorna Kwai-Ping; Shen, Juan; Chien, Lung-Chang; Liang, Zhan; Glick, Ronald M; Morone, Natalia E; Chasens, Eileen R

    2016-01-01

    The purpose of this study was to report sleep quality from 4 weeks of auricular point acupressure that was designed for chronic low back pain and determine the relationship between pain intensity and sleep quality. Participants were randomized into the APA group (n = 30) or the sham-APA group (n = 31). At baseline assessment, 87% of the participants reported poor sleep quality. Participants who received APA had decreased daytime disturbance and improved global Pittsburgh Sleep Quality Index scores at end of intervention (EOI) and 1-month follow up compared to participants in the sham-APA group. For the APA group, both the sleep duration and wake after sleep onset decreased gradually during the 4-week APA (0.56% and 0.23% daily change, respectively). PMID:26244591

  16. 2015 Annual Report of the American Psychological Association.

    Science.gov (United States)

    2016-01-01

    Presents the 2015 Annual Report of the American Psychological Association. In his introduction, President Barry Anton describes how 2015 was among APA's most challenging. Although 2015 ushered in an era of greater transparency within the association and enhanced communications to members and the public, it also required painful self-reflection stemming from the revelations of an independent review by an outside law firm. The review examined the question of whether APA played any role related to the Bush administration's use of abusive interrogation techniques during the war on terror. Anton's introduction also discusses (1) the APA convention, (2) representing APA at a White House meeting with health care providers and insurance companies, (3) APA's effort to increase the number of APA-accredited internships, (4) international activities, and (5) the global summit on psychology and integrated care. (PsycINFO Database Record PMID:27504583

  17. Genome-wide alternative polyadenylation in animals: insights from high-throughput technologies

    Institute of Scientific and Technical Information of China (English)

    Yu Sun; Yonggui Fu; Yuxin Li; Anlong Xu

    2012-01-01

    Alternative polyadenylation (APA) plays an important role in gene expression by affecting mRNA stability,translation,and translocation in cells.However,genome-wide APA events have only recently been subjected to more systematic analysis with newly developed high-throughput methods.In this review,we focus on the recent technological development of APA analyses on a genome-wide scale,as well as the impact of APA switches on a number of critical biological processes in animals,including cell proliferation,differentiation,and oncogenic transformation.With the highly enlarged scope of genome-wide APA analyses,the APA regulations of various biological processes have increasingly become a new paradigm for the regulation of gene transcription and translation.

  18. Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal

    OpenAIRE

    Lackford, Brad; Yao, Chengguo; Charles, Georgette M.; Weng, Lingjie; Zheng, Xiaofeng; Choi, Eun-A; Xie, Xiaohui; Wan, Ji; Xing, Yi; Freudenberg, Johannes M.; Yang, Pengyi; Jothi, Raja; Hu, Guang; Shi, Yongsheng

    2014-01-01

    mRNA alternative polyadenylation (APA) plays a critical role in post-transcriptional gene control and is highly regulated during development and disease. However, the regulatory mechanisms and functional consequences of APA remain poorly understood. Here, we show that an mRNA 3′ processing factor, Fip1, is essential for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Fip1 promotes stem cell maintenance, in part, by activating the ESC-specific APA profiles to ensure the ...

  19. Association of KCNJ5 gene missense mutations with aldosterone-producing adenoma and primary hyperaldosteronism

    Institute of Scientific and Technical Information of China (English)

    邵丹

    2013-01-01

    Objective To detect the KCNJ5 gene variations in aldosterone-producing adenoma (APA) with primary hyperaldosteronism (PA) ,and to investigate the association of the KCNJ5 gene missense mutations with APA and PA.Methods A total of 46 APA tumors and their clinical characteristics were collected from Hypertension Center of the People’s Hospital of Xinjiang Uygur Autonomous Region,and all the tumors were confirmed by pathology.

  20. The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation*

    OpenAIRE

    Davis, Ryan; Shi, Yongsheng

    2014-01-01

    The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3′ ends through a process called mRNA alternative polyadenylation (APA). Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also prov...

  1. APAとIHAの頻度(第3回副腎静脈サンプリング研究会プロシーディングス)

    OpenAIRE

    西川, 哲男; 齋藤, 淳; 大村, 昌夫; NISHIKAWA, Tetsuo; SAITO, Jun; OMURA, Masao

    2006-01-01

    Hypertension caused by primary aldosteronism (PA) due to aldosterone-producing adenoma (APA) is curable by surgically removing the lesion. Differential diagnosis of APA from idiopathic hyperaldosteronism (IHA) is critical before a clinician can decide how to treat each of the condition, since APA is treated by resection of the adrenal lesion while IHA is treated by administration of aldosterone blockades. Clinical records of 65 PA patients, who visited our hospitals from 1995 to 1999, were an...

  2. The Economics of Advance Pricing Agreements

    OpenAIRE

    Becker, Johannes; Davies, Ronald B.; Jakobs, Gitte

    2014-01-01

    Advance pricing agreements (APAs) determine transfer prices for intra-fi?rm transactions in advance. This paper interprets these contracts as a means to overcome a hold-up problem that occurs because governments cannot commit to non-excessive future tax rates. In addition, with private information, just as in practice, our APAs will be complex and require lengthy negotiations. Never- theless, implemented APAs lead to a Pareto improvement even when all agents are risk neutral. However, not all...

  3. Downscaling Alkaline Phosphatase Activity in a Subtropical Reservoir

    Science.gov (United States)

    Tseng, Y.

    2011-12-01

    This research was conducted by downscaling study to understand phosphorus (P)-deficient status of different plankton and the role of alkaline phosphatase activity (APA) in subtropical Feitsui Reservoir. Results from field survey showed that bulk APA (1.6~95.2 nM h-1) was widely observed in the epilimnion (0~20 m) with an apparent seasonal variations, suggesting that plankton in the system were subjected to P-deficient seasonally. Mixed layer depth (an index of phosphate availability) is the major factor influencing the variation of bulk APA and specific APA (124~1,253 nmol mg C-1 h-1), based on multiple linear regression analysis. Size-fractionated APA assays showed that picoplankton (size 0.2~3 um) contributed most of the bulk APA in the system. In addition, single-cell APA detected by enzyme-labeled fluorescence (ELF) assay indicated that heterotrophic bacteria are the major contributors of APA. Thus, we can infer that bacteria play an important role in accelerating P-cycle within P-deficient systems. Light/nutrient manipulation bioassays showed that bacterial growth was directly controlled by phosphate, while picocyanobacterial growth is controlled by light and can out-compete bacteria under P-limited condition with the aid of light. Further analysis revealed that the strength of summer typhoon is a factor responsible for the inter-annual variability of bulk and specific APA. APA study demonstrated the episodic events (e.g. strong typhoon and extreme precipitation) had significant influence on APA variability in sub-tropical to tropical aquatic ecosystems. Hence, the results herein will allow future studies on monitoring typhoon disturbance (intensity and frequency) as well as the APA of plankton during summer-to-autumn in subtropical systems.

  4. The Role of Proprioception in the Sagittal Setting of Anticipatory Postural Adjustments During Gait Initiation

    OpenAIRE

    Pereira Marcelo P.; Pelicioni Paulo H. Silva; Gobbi Lilian T.B.

    2015-01-01

    Purpose. Previous studies have studied the role of proprioception on the setting of anticipatory postural adjustments (APA) during gait initiation. However, these studies did not investigate the role of proprioception in the sagittal APA setting. We aimed to investigate the role of proprioception manipulation to induce APA sagittal adaptations on gait initiation. Methods. Fourteen healthy adults performed gait initiation without, and with, vibration applied before movement onset, and during m...

  5. Laparoscopic Adrenalectomy for Bilateral Metachronous Aldosteronomas

    OpenAIRE

    Rizek, Philippe; Gorecki, Piotr; Lindenmayer, Aristid; Moktan, Sabita

    2011-01-01

    Introduction: Primary aldosteronism affects 5% to 13% of patients with hypertension. Idiopathic bilateral hyperplasia (IHA) and unilateral aldosterone-producing adenoma (APA) are the most common types of primary aldosteronism. Bilateral APA is a very rare entity with only a few reports in the literature. We present the case of a patient with metachronous bilateral APA treated with metachronous bilateral total and near total adrenalectomy. Case Report: A 66-year-old female was evaluated for hy...

  6. Affine Projection Algorithm Using Regressive Estimated Error

    OpenAIRE

    Zhang, Shu; Zhi, Yongfeng

    2011-01-01

    An affine projection algorithm using regressive estimated error (APA-REE) is presented in this paper. By redefining the iterated error of the affine projection algorithm (APA), a new algorithm is obtained, and it improves the adaptive filtering convergence rate. We analyze the iterated error signal and the stability for the APA-REE algorithm. The steady-state weights of the APA-REE algorithm are proved to be unbiased and consist. The simulation results show that the proposed algorithm has a f...

  7. Theory of affine projection algorithms for adaptive filtering

    CERN Document Server

    Ozeki, Kazuhiko

    2016-01-01

    This book focuses on theoretical aspects of the affine projection algorithm (APA) for adaptive filtering. The APA is a natural generalization of the classical, normalized least-mean-squares (NLMS) algorithm. The book first explains how the APA evolved from the NLMS algorithm, where an affine projection view is emphasized. By looking at those adaptation algorithms from such a geometrical point of view, we can find many of the important properties of the APA, e.g., the improvement of the convergence rate over the NLMS algorithm especially for correlated input signals. After the birth of the APA in the mid-1980s, similar algorithms were put forward by other researchers independently from different perspectives. This book shows that they are variants of the APA, forming a family of APAs. Then it surveys research on the convergence behavior of the APA, where statistical analyses play important roles. It also reviews developments of techniques to reduce the computational complexity of the APA, which are important f...

  8. Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer

    OpenAIRE

    Ichinose, Junji; Watanabe, Kousuke; Sano, Atsushi; Nagase, Takahide; Nakajima, Jun; Fukayama, Masashi; Yatomi, Yutaka; Ohishi, Nobuya; Takai, Daiya

    2014-01-01

    Alternative polyadenylation (APA), which induces shortening of the 3′UTR, is emerging as an important phenomenon in gene regulation. APA is involved in development, cancer and cell proliferation. APA may lead to disruption of microRNA-mediated gene silencing in cancer cells via detachment of microRNA binding sites. We studied the correlation between the APA profile and the tumor aggressiveness in cases of lung cancer. We selected the top 10 genes showing significant 3′UTR shortening in lung c...

  9. Anticipatory postural adjustments are unaffected by age and are not absent in patients with the freezing of gait phenomenon.

    Science.gov (United States)

    Plate, A; Klein, K; Pelykh, O; Singh, A; Bötzel, K

    2016-09-01

    In bipedal gait, the initiation of the first step is preceded by a complex sequence of movements which shift the centre of mass of the body towards the stance foot to allow for a step of the swing foot. These anticipatory postural adjustments (APAs) have been investigated in order to elucidate movement strategies in healthy and diseased persons. We studied the influence of several external parameters (age, type of step initiation) on APAs and investigated whether Parkinsonian patients may have different APAs. As a result, we found that externally elicited steps were preceded by faster and larger APAs than self-timed steps. Parkinsonian patients without the freezing of gait (FOG) phenomenon showed overall slightly reduced APAs but did not clearly differ from patients with FOG. Multiple APAs were seen in up to 25 % of the steps of the patients and in a much lower percentage of the steps of control subjects. The results indicate that APAs are significantly influenced by the timing of a step, i.e. are larger in externally elicited steps. The patients showed an overall preserved APA pattern but slowed movements and amplitude, indicating that increased bradykinesia due to progressive illness is a plausible explanation for these findings. The freezing phenomenon is not explained by a general absence or massive reduction in APA measures. PMID:27173496

  10. Low Complexity Adaptive Equalizers for Underwater Acoustic Communications

    Institute of Scientific and Technical Information of China (English)

    Masoumeh SOFLAEI; Paeiz AZMI

    2014-01-01

    Interference-signals-due-to-scattering-from-surface-and-reflecting-from-bottom-is-one-of-the-most-important-problems-of-reliable-communications-in-shallow-water-channels.-To-solve-this-problem,-one-of-the-best-suggested-ways-is-to-use-adaptive-equalizers.-Convergence-rate-and-misadjustment-error-in-adaptive-algorithms-play-important-roles-in-adaptive-equalizer-performance.-In-this-paper,-affine-projection-algorithm-(APA),-selective-regressor-APA(SR-APA),-family-of-selective-partial-update-(SPU)-algorithms,-family-of-set-membership-(SM)-algorithms-and-selective-partial-update-selective-regressor-APA-(SPU-SR-APA)-are-compared-with-conventional-algorithms-such-as-the-least-mean-square-(LMS)-in-underwater-acoustic-communications.-We-apply-experimental-data-from-the-Strait-of-Hormuz-for-demonstrating-the-efficiency-of-the-proposed-methods-over-shallow-water-channel.-We-observe-that-the-values-of-the-steady-state-mean-square-error-(MSE)-of-SR-APA,-SPU-APA,-SPU-normalized-least-mean-square-(SPU-NLMS),-SPU-SR-APA,-SM-APA-and-SM-NLMS-algorithms-decrease-in-comparison-with-the-LMS-algorithm.-Also-these-algorithms-have-better-convergence-rates-than-LMS-type-algorithm.

  11. What Is Psychiatry?

    Medline Plus

    Full Text Available ... diagnoses are based on criteria established in APA's Diagnostic and Statistical Manual of Mental Disorders ( DSM-5 ), which contains descriptions, symptoms and other criteria for ...

  12. Auricular point acupressure for chronic pain: a feasibility study of a 4-week treatment protocol.

    Science.gov (United States)

    Yeh, Chao Hsing; Chien, Lung-Chang; Huang, Li Chun; Suen, Lorna Kwai-Ping

    2014-01-01

    This 1-group, 4-week observational study aimed to (1) assess the feasibility of recruiting, retention, and completion of a 4-week auricular point acupressure (APA) treatment protocol for chronic pain in adult patients and (2) assess the effects of APA in pain reduction (pain severity and pain interference) among these patients. The participants received a 4-week APA treatment protocol in weekly cycles. Each weekly cycle included 5 days with APA seeds taped onto the ear and 2 days without. Each participant was called every day to monitor adherence to the treatment protocol (the actual times the participant pressed the seeds each day and the duration of applied pressure), to answer analgesic use, and to answer the pain intensity questionnaire. Thirty participants were initially enrolled in this study, but 5 did not continue. The retention rate was 83% (n = 25). Approximately 60% of the participants (n = 15) adhered to the 4-week APA and completed all data assessments. At baseline assessment, only 40% of all participants (n = 12 of 30) were confident that APA would reduce and eliminate pain; nonetheless, all participants reported fewer episodes of pain occurrences and pain intensity with the APA treatment. For the participants who completed the 4-week APA protocol (n = 15), 96% (n = 14) decreased analgesic medication intake and 88% (n = 13) felt "much better" after the APA treatment. Participants reported an average reduction of 63% in the worst pain intensity at day 7. By the end of the 4-week APA protocol, an even greater reduction in pain intensity was reported (66%, n = 10, at day 28). The participants who did not complete the treatment protocol reported an average pain reduction of 29%, which fluctuated to 22% before they dropped out. Auricular point acupressure is feasible for patients with chronic pain. The preliminary findings of this feasibility study show a reduction in pain intensity and improvement in physical function, which demonstrate the potential for

  13. Separate but Equal: School Psychology's Search for Organizational Identity.

    Science.gov (United States)

    Fagan, Thomas K.

    1993-01-01

    Traces organizational roots of Division 16 of the American Psychological Association (APA) and of National Association of School Psychologists from the founding of APA to present. Focuses on significance of these organizations and their contributions to development of school psychology. Describes trends in structure and characteristics of the…

  14. A Randomized Clinical Trial of Auricular Point Acupressure for Chronic Low Back Pain: A Feasibility Study

    Directory of Open Access Journals (Sweden)

    Chao Hsing Yeh

    2013-01-01

    Full Text Available Objectives. This prospective, randomized clinical trial (RCT was designed to investigate the feasibility and effects of a 4-week auricular point acupressure (APA for chronic low back pain (CLBP. Methods. Participants were randomized to either true APA (true acupoints with taped seeds on the designated ear points for CLBP or sham APA (sham acupoints with taped seeds but on different locations than those designated for CLBP. The duration of treatment was four weeks. Participants were assessed before treatment, weekly during treatment, and 1 month following treatment. Results. Participants in the true APA group who completed the 4-week APA treatment had a 70% reduction in worst pain intensity, a 75% reduction in overall pain intensity, and a 42% improvement in disability due to back pain from baseline assessment. The reductions of worst pain and overall pain intensity in the true APA group were statistically greater than participants in the sham group (P<0.01 at the completion of a 4-week APA and 1 month followup. Discussion. The preliminary findings of this feasibility study showed a reduction in pain intensity and improvement in physical function suggesting that APA may be a promising treatment for patients with CLBP.

  15. Courseware Development with Animated Pedagogical Agents in Learning System to Improve Learning Motivation

    Science.gov (United States)

    Chin, Kai-Yi; Hong, Zeng-Wei; Huang, Yueh-Min; Shen, Wei-Wei; Lin, Jim-Min

    2016-01-01

    The addition of animated pedagogical agents (APAs) in computer-assisted learning (CAL) systems could successfully enhance students' learning motivation and engagement in learning activities. Conventionally, the APA incorporated multimedia materials are constructed through the cooperation of teachers and software programmers. However, the thinking…

  16. A case of endometrioid adenocarcinoma developing 8 years after conservative management for atypical polypoid adenomyoma

    OpenAIRE

    Inoue, Kayo; Tsubamoto, Hiroshi; Hori, Masateru; Ogasawara, Toshitada; Takemura, Tadashi

    2014-01-01

    •Endometrioid adenocarcinoma may develop during the long-term follow-up of APA.•Atypical polypoid adenomyoma is a precursor of endometrioid adenocarcinoma.•Careful follow-up is needed for the conservative management of APA.

  17. Animated pedagogical agents effects on enhancing student motivation and learning in a science inquiry learning environment

    NARCIS (Netherlands)

    Meij, van der H.; Meij, van der J.; Harmsen, Ruth

    2015-01-01

    This study focuses on the design and testing of a motivational animated pedagogical agent (APA) in an inquiry learning environment on kinematics. The aim of including the APA was to enhance students’ perceptions of task relevance and self-efficacy. Given the under-representation of girls in science

  18. Self-Efficacy and Preparation of Scholarly Writing: Online Doctoral Coursework to Comprehensive Examination--a Mixed Method Study

    Science.gov (United States)

    Thomas, Sonya C.

    2013-01-01

    Writing is seldom explicitly taught, most specifically, in academic and scholarly writing. Therefore, this mixed methods correlational phenomenology research study explored the correlation between self-efficacy perception and course room preparation for the comprehensive examination, APA standards in the course room, APA standards evaluation for…

  19. 75 FR 3122 - Policy Statement Concerning Cooperation by Individuals in Its Investigations and Related...

    Science.gov (United States)

    2010-01-19

    ... Procedure Act (``APA''), 5 U.S.C. 553, regarding notice of proposed rulemaking, opportunities for public... notice and comment are required by the APA or another statute and are therefore not applicable. List of...: ] PART 202--INFORMAL AND OTHER PROCEDURES 1. The authority citation for Part 202 continues to read,...

  20. 77 FR 26181 - Authorization To Redelegate Settlement Authority for Claims Submitted Under the Federal Tort...

    Science.gov (United States)

    2012-05-03

    ... of these claims. Administrative Procedure Act (APA) Notice and comment rulemaking is not required for this final rule. Under the APA, ``rules of agency organization, procedure or practice,'' 5 U.S.C. 553(b... OF THE DEPARTMENT OF JUSTICE 0 1. The authority citation for 28 CFR Part 0 continues to read...

  1. 76 FR 6687 - Bank Secrecy Act Compliance; Fair Credit Reporting; Technical Amendments

    Science.gov (United States)

    2011-02-08

    ... CFR Part 103 to 31 CFR Chapter X. See 75 FR 65806, October 26, 2010. The OCC is amending provisions of.... Administrative Procedure Act and Effective Date Under 5 U.S.C. 553(b)(B) of the Administrative Procedure Act (APA... by the APA are unnecessary because the final rule makes technical amendments to citations...

  2. 77 FR 76839 - Home Mortgage Disclosure (Regulation C): Adjustment To Asset-Size Exemption Threshold

    Science.gov (United States)

    2012-12-31

    .... Procedural Requirements Administrative Procedure Act Under the Administrative Procedure Act (APA), notice and...) of the APA, the required publication or service of a substantive rule shall be made not less than 30...: PART 1003--HOME MORTGAGE DISCLOSURE (REGULATION C) 0 1. The authority citation for part 1003...

  3. Ethics Education and Adjudication within Psychology.

    Science.gov (United States)

    Mills, David H.

    1984-01-01

    Provides an overview of the formal ethics system within psychology. Describes the structure of the American Psychological Association (APA) and state ethics systems, functions of APA's Committee on Scientific and Professional Ethics and Conduct, and its procedures for handling complaints. (Author/CMG)

  4. Neuropsychological Training in American Psychological Association-Accredited and Nonaccredited School Psychology Programs.

    Science.gov (United States)

    D'Amato, Rik Carl; And Others

    1992-01-01

    Examines whether American Psychological Association (APA)-accredited and nonaccredited programs differ in views and offerings of neuropsychological training. Of 72 programs surveyed, 59 percent of APA-accredited programs and 53 percent of nonaccredited programs offered course work in neuropsychology. Found that students viewed neuropsychological…

  5. Induction and characterization of multianalyte antibodies against penicillins in egg yolk

    NARCIS (Netherlands)

    Leuw, de P.; Kapa, G.; Petz, M.; Schreurs, F.J.G.; Kan, C.A.

    1997-01-01

    Antibodies against penicillins were induced in eggs of laying hens after immunization with 6-aminopenicillanic acid (6-APA) coupled to keyhole limpet hemocyanin (KLH). Development of the antibody titer was monitored by an indirect enzyme-linked immunosorbent assay (ELISA), with 6-APA coupled to oval

  6. Tobacco industry influence on the definition of tobacco related disorders by the American Psychiatric Association

    OpenAIRE

    Neuman, M; Bitton, A; Glantz, S

    2005-01-01

    Objective: The Diagnostic and statistical manual of mental disorders, third edition (DSM-III), published by the American Psychiatric Association (APA) in 1980, included the first official definitions by the APA of tobacco dependence and tobacco withdrawal. Tobacco industry efforts to influence the DSM-III were investigated.

  7. Animated Pedagogical Agents Effects on Enhancing Student Motivation and Learning in a Science Inquiry Learning Environment

    Science.gov (United States)

    van der Meij, Hans; van der Meij, Jan; Harmsen, Ruth

    2015-01-01

    This study focuses on the design and testing of a motivational animated pedagogical agent (APA) in an inquiry learning environment on kinematics. The aim of including the APA was to enhance students' perceptions of task relevance and self-efficacy. Given the under-representation of girls in science classrooms, special attention was given to…

  8. Psychologists Back Women, Chuck Magazine, Gear up for NHI

    Science.gov (United States)

    Science, 1977

    1977-01-01

    Last year the American Psychological Association (APA) voted not to hold future conventions in states where the Equal Rights Amendment has not been passed. At its annual meeting, the APA also decided not to print a quarterly psychology magazine. Meeting emphasis concerning psychotherapy was in anticipation of Natural Health Insurance. (MA)

  9. Internship Training Directors' Perceptions of School Psychology Internship Applicants

    Science.gov (United States)

    Mahoney, Emery B.; Perfect, Michelle M.; Edwinson, Roxanne M.

    2015-01-01

    Since the mid-1990s, an imbalance between the number of available American Psychological Association (APA)-accredited internships and applicants has existed. In 2014, 14% of predoctoral psychology students who applied for internships accredited by the APA or members of the Association of Psychology Postdoctoral and Internship Centers (APPIC) did…

  10. Ethics as an Undergraduate Psychology Outcome: When, Where, and How to Teach It

    Science.gov (United States)

    Ruiz, Ana; Warchal, Judith

    2014-01-01

    The American Psychological Association (APA) recently approved a new set of "Guidelines for the undergraduate psychology major, version 2.0" (APA, 2013a) which addressed ethics specifically. Yet the teaching of ethics receives little attention in publications, national and international institutes, and conferences. Few guidelines for…

  11. Pedophilia and the Culture Wars.

    Science.gov (United States)

    Zuriff, G. E.

    2000-01-01

    Discusses reaction to research findings published in a journal of the American Psychological Association (APA) which concluded that classifying sexual behavior between adults and children as abuse merely because it is considered illegal or immoral, even in the absence of harm, is not scientifically valid. Notes the APA's stand on the study's…

  12. What Is Psychiatry?

    Medline Plus

    Full Text Available ... News Releases Message from the President Reporting on Mental Health Conditions APA Blogs Media Registration - Annual Meeting Advocacy & ... Foundation APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Sign In Join General Residents Medical Students International ...

  13. Probability as certainty : Dichotomous thinking and the misuse of p values

    NARCIS (Netherlands)

    Hoekstra, Rink; Finch, Sue; Kiers, Henk A.L.; Johnson, Addie

    2006-01-01

    Significance testing is widely used and often criticized. The Task Force on Statistical Inference of the American Psychological Association (TFSI, APA; Wilkinson & TFSI, 1999) addressed the use of significance testing and made recommendations that were incorporated in the fifth edition of the APA Pu

  14. Statistical Methods in Psychology Journals.

    Science.gov (United States)

    Willkinson, Leland

    1999-01-01

    Proposes guidelines for revising the American Psychological Association (APA) publication manual or other APA materials to clarify the application of statistics in research reports. The guidelines are intended to induce authors and editors to recognize the thoughtless application of statistical methods. Contains 54 references. (SLD)

  15. Yeki Bood/Yeki Na Bood: Writing and Publishing as a Teacher Researcher.

    Science.gov (United States)

    Fecho, Bob

    2003-01-01

    Discusses considerations faced by practitioner researchers as they write for publication, particularly as they encounter the template of the Publication Manual of the American Psychological Association (APA). Argues that some APA conventions--such as beginning an article with theory rather than the story of the research--do not suite the purposes…

  16. Teen Dating Violence Prevention Program Assessment

    Science.gov (United States)

    Lucas, Quincy Arrianna Rose

    2013-01-01

    The American Psychological Association (APA) has identified the prevention of and intervention in relationship violence as a top priority (APA, n.d.). According to the Center for Disease Control and Prevention's 2012 Teen Dating Violence Fact Sheet, dating violence is a serious problem in the United States. In accordance with Foshee et al. (1998):…

  17. Joint effect of freshwater plume and coastal upwelling on phytoplankton growth off the Changjiang River

    Directory of Open Access Journals (Sweden)

    Y.-F. Tseng

    2013-06-01

    Full Text Available Changjiang River discharges vast amount of unbalanced nutrients (dissolved inorganic nitrogen (N and phosphorus (P with N / P > 80 in general into the East China Sea during summertime. To explore nutrient dynamics and P stress potential for phytoplankton, a cruise was conducted in the Changjiang plume during summer 2011. With 3-D observations of nutrients, chlorophyll a (Chl a, and bulk alkaline phosphatase activity (APA, we concluded that the Changjiang Diluted Water (CDW and coastal upwelling significantly influenced the horizontal and vertical heterogeneities of phytoplankton P-deficiency in the plume. Allochthonous APA was detected at nutrient-enriched freshwater end. Excessive N (~10 to 112 µM was obserevd throughout the entire plume surface. In the plume fringe where featured by stratification and excess N, diapycnal phosphate supply was blocked to stimulate APA for phytoplankton growth. We observed upwelling outcrops just attaching the turbidity front at seaward side, where Chl a peaked yet much less APA was detected. An external phosphate supply from subsurface, which stimulated phytoplankton growth but inhibited APA, was suggested and the supply was likely sourced from the Nearshore Kuroshio Branch Current. In such hydrographically complicated Changjiang plume, phosphate supply instead of its concentration was more important determining the expression of APA. Meanwhile, allochthounous APA may also alter the usefulness of APA as a P-stress indicator.

  18. Reporting and Interpreting Effect Size in Quantitative Agricultural Education Research

    Science.gov (United States)

    Kotrlik, Joe W.; Williams, Heather A.; Jabor, M. Khata

    2011-01-01

    The Journal of Agricultural Education (JAE) requires authors to follow the guidelines stated in the Publication Manual of the American Psychological Association [APA] (2009) in preparing research manuscripts, and to utilize accepted research and statistical methods in conducting quantitative research studies. The APA recommends the reporting of…

  19. An Introduction to Confidence Intervals for Both Statistical Estimates and Effect Sizes.

    Science.gov (United States)

    Capraro, Mary Margaret

    This paper summarizes methods of estimating confidence intervals, including classical intervals and intervals for effect sizes. The recent American Psychological Association (APA) Task Force on Statistical Inference report suggested that confidence intervals should always be reported, and the fifth edition of the APA "Publication Manual" (2001)…

  20. An Introductory Summary of Various Effect Size Choices.

    Science.gov (United States)

    Cromwell, Susan

    This paper provides a tutorial summary of some of the many effect size choices so that members of the Southwest Educational Research Association would be better able to follow the recommendations of the American Psychological Association (APA) publication manual, the APA Task Force on Statistical Inference, and the publication requirements of some…

  1. Interpreting and Reporting Effect Sizes in Research Investigations.

    Science.gov (United States)

    Tapia, Martha; Marsh, George E., II

    Since 1994, the American Psychological Association (APA) has advocated the inclusion of effect size indices in reporting research to elucidate the statistical significance of studies based on sample size. In 2001, the fifth edition of the APA "Publication Manual" stressed the importance of including an index of effect size to clarify research…

  2. Phosphorus use by planktonic communities in a large regulated Mediterranean river.

    Science.gov (United States)

    Artigas, J; Soley, S; Pérez-Baliero, M C; Romaní, A M; Ruiz-González, C; Sabater, S

    2012-06-01

    The regulation of large rivers to meet human requirements (e.g. hydroelectricity production, flood prevention, recreation activities) alters the longitudinal distribution of plankton communities and may affect their capacity to use nutrients and organic matter. Here we analyzed phosphorus (P) availability and use by phytoplankton and bacterioplankton in 6 upstream and 5 downstream sites from a reservoir system in the Ebro River (N Spain). Alkaline phosphatase activity (APA) was related to nutrient availability and biomass of both phytoplankton and bacterioplankton. During dry periods phytoplankton and bacterioplankton APA was inversely correlated to P availability in the water, but these patterns became less clear during wet periods. The phosphorus-APA patterns were more consistent in the upstream sites and especially during dry periods. Although phytoplankton APA was 6-40 times greater than that of bacterioplankton, APA per unit of biomass suggested that bacterioplankton was more efficient at utilizing dissolved organic phosphorus (DOP) in the upstream section during dry periods. Imbalanced N:P ratios in the particulate (N:P ranging 133-170) and dissolved (N:P ranging 301-819) water fractions confirmed the strong P limitation in these upstream communities. The phosphorus-APA patterns were weaker in the downstream section and during wet periods. The reservoirs caused a change in the downstream dynamics, where bacterioplankton biomass was positively correlated to APA but APA per unit of biomass decreased. Our findings reveal that river regulation drives changes in plankton use of organic phosphorus, especially during extreme dry periods. PMID:22503678

  3. FBRM and PVM investigations of the double feed semi-batch crystallization of 6-aminopenicillanic acid

    Institute of Scientific and Technical Information of China (English)

    Min SU; Lin WANG; Hua SUN; Jingkang WANG

    2009-01-01

    6-Aminopenicillanic acid (6-APA) is a crucial pharmaceutical intermediate in the chemistry of semi-synthetic antibiotics. The focused beam reflectance measurement (FBRM) technology and particle vision measurement (PVM) technology were employed to the processes of online-monitoring of 6-APA crystallization behavior in a double-feeding semi-batch crystallizer. Experiments were carried out with four kinds of double-feeding policies and the results were compared with the traditional single-feeding. Records and analysis of FBRM indicated that the nucleation of double feeding policy was much higher than single policy, and chord length of 6-APA was almost determined and had little change after the nucleation peak. Ostwald ripening process had no significant effect on further growth of 6-APA crystal. PVM images showed that the crystal habit of 6-APA was continuously changed during the crystallization process. The development of (002) face in the final crystal for the five feeding policies were different.

  4. Alternative polyadenylation of tumor suppressor genes in small intestinal neuroendocrine tumors

    DEFF Research Database (Denmark)

    Rehfeld, Anders Aagaard; Plass, Mireya; Døssing, Kristina;

    2014-01-01

    The tumorigenesis of small intestinal neuroendocrine tumors (SI-NETs) is poorly understood. Recent studies have associated alternative polyadenylation (APA) with proliferation, cell transformation, and cancer. Polyadenylation is the process in which the pre-messenger RNA is cleaved at a polyA site...... or 3' untranslated regions. Among these, 11 genes had been previously associated with cancer, with 4 genes being known tumor suppressors: DCC, PDZD2, MAGI1, and DACT2. We validated the APA in three out of three cases with quantitative real-time-PCR. Our findings suggest that changes of APA pattern...... in these 16 genes could be involved in the tumorigenesis of SI-NETs. Furthermore, they also point to APA as a new target for both diagnostic and treatment of SI-NETs. The identified genes with APA specific to the SI-NETs could be further tested as diagnostic markers and drug targets for disease prevention...

  5. Anticipatory Postural Adjustments in Standing Reach Tasks Among Middle-Aged Adults With Diplegic Cerebral Palsy.

    Science.gov (United States)

    Su, Ivan Y W; Chow, Daniel H K

    2016-01-01

    Previous studies reported that children with cerebral palsy (CP) exhibited premature anticipatory postural adjustments (APAs) with high variability and excessive activity in the frontal plane. To better understand the effects of gross motor functioning level on APAs over the life course, the authors examined the presence and consistency of APAs in 11 adults with diplegia at 2 functioning levels against 8 age-matched healthy adults during unilateral and bilateral reaching. Results revealed an anticipatory vertical torque (TZ) and an increased likelihood of APAs during bilateral reaching for the lower functioning group. It is postulated that APAs may first emerge in TZ in CP. Results also indicated an excessive premovement postural activity in the frontal plane in both CP groups. PMID:26730748

  6. Pelvic magnetic resonance imaging angioanatomy of the arterial blood supply to the penis in suspected prostate cancer patients

    International Nuclear Information System (INIS)

    Highlights: • Three patterns of penile arterial supply (according to the classification of Stéphane Droupy). • Our classification about accessory pudendal artery. • Origin of accessory pudendal artery. - Abstract: Purpose: To describe the internal pudendal artery (IPA) and accessory pudendal artery (APA) detected by magnetic resonance (MR) angiography to help surgeons to find and preserve them during radical prostatectomy (RP). Materials and methods: Constrast-enhanced MR 3.0 T angiography of the pelvis were performed in 111 male patients suspected diagnosis of prostate cancer (PCa), and describe the penile arterial blood supply. Results: There are three patterns of the arterial blood supply to the penis (IPA and/or APA) accounting for 51.4%, 46.8% and 1.8% of cases, respectively. About the accessory pudendal artery (APA): 54/111 (48.6%) patients had APA with five different branching patterns, they were type I (APA bilateral symmetry): 17 (31.5%); type II (APA bilateral asymmetry): 1 (1.9%); type III (APA unilateral lateral): 13 (24%); type IV (APA unilateral apical): 21 (38.9%); type V (APA unilateral mix): 2 (3.7%). APA origin were from inferior epigastric artery (IEA): 7 (9.5%); from inferior vesical artery (IVA): 32 (43.2%); from obturator artery (OA): 35 (47.3%). Conclusion: A precise angioanatomic evalutation of arteries destined to the penis by MR angiography pre-operation for male pelvic organs will help surgeons to preserve them and contributes to reduce the erectile dysfunction after these procedures

  7. Pelvic magnetic resonance imaging angioanatomy of the arterial blood supply to the penis in suspected prostate cancer patients

    Energy Technology Data Exchange (ETDEWEB)

    Thai, Cao Tan, E-mail: bstanhatinh@gmail.com [Department of Urology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France); IADI Laboratory, INSERM-U947, Brabois Hospital, University Hospital of Nancy, Tour Drouet, rue du Morvan, 54511 Vandoeuvre Lès Nancy Cedex (France); Karam, Ibrahim Michel [Clinical Epidemiology and Evaluation Department, University Hospital of Nancy (France); Department of Anatomy, Faculty of Medicine Nancy, 9 Avenue de la Foret de haye BP, 54505 Vandoeuvre Lès Nancy Cedex (France); Nguyen-Thi, Phi Linh [Clinical Epidemiology and Evaluation Department, University Hospital of Nancy (France); INSERM, CIC-EC CIE6, 92 Avenue du Maréchal de Lattre de Tassigny, 54000 Nancy (France); Lefèvre, Frédéric [Department of Radiology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France); Hubert, Jacques [Department of Urology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France); IADI Laboratory, INSERM-U947, Brabois Hospital, University Hospital of Nancy, Tour Drouet, rue du Morvan, 54511 Vandoeuvre Lès Nancy Cedex (France); Felblinger, Jacques [IADI Laboratory, INSERM-U947, Brabois Hospital, University Hospital of Nancy, Tour Drouet, rue du Morvan, 54511 Vandoeuvre Lès Nancy Cedex (France); Eschwège, Pascal [Department of Urology, Brabois Hospital, University Hospital of Nancy, Rue du Morvan, 54500 Vandoeuvre Lès Nancy Cedex (France)

    2015-05-15

    Highlights: • Three patterns of penile arterial supply (according to the classification of Stéphane Droupy). • Our classification about accessory pudendal artery. • Origin of accessory pudendal artery. - Abstract: Purpose: To describe the internal pudendal artery (IPA) and accessory pudendal artery (APA) detected by magnetic resonance (MR) angiography to help surgeons to find and preserve them during radical prostatectomy (RP). Materials and methods: Constrast-enhanced MR 3.0 T angiography of the pelvis were performed in 111 male patients suspected diagnosis of prostate cancer (PCa), and describe the penile arterial blood supply. Results: There are three patterns of the arterial blood supply to the penis (IPA and/or APA) accounting for 51.4%, 46.8% and 1.8% of cases, respectively. About the accessory pudendal artery (APA): 54/111 (48.6%) patients had APA with five different branching patterns, they were type I (APA bilateral symmetry): 17 (31.5%); type II (APA bilateral asymmetry): 1 (1.9%); type III (APA unilateral lateral): 13 (24%); type IV (APA unilateral apical): 21 (38.9%); type V (APA unilateral mix): 2 (3.7%). APA origin were from inferior epigastric artery (IEA): 7 (9.5%); from inferior vesical artery (IVA): 32 (43.2%); from obturator artery (OA): 35 (47.3%). Conclusion: A precise angioanatomic evalutation of arteries destined to the penis by MR angiography pre-operation for male pelvic organs will help surgeons to preserve them and contributes to reduce the erectile dysfunction after these procedures.

  8. Auricular point acupressure as an adjunct analgesic treatment for cancer patients: a feasibility study.

    Science.gov (United States)

    Yeh, Chao Hsing; Chien, Lung-Chang; Chiang, Yi Chien; Ren, Dianxu; Suen, Lorna Kwai-Ping

    2015-06-01

    This study aimed (1) to examine the feasibility of an auricular point acupressure (APA) research protocol in terms of recruitment and for the assessment and management of pain and (2) to examine the potential APA analgesic effects for cancer patients. This study was a repeated-measures one-group design. Participants were recruited from the cancer center follow-up clinic affiliated with a large university hospital in the northeastern United States. Participants included 50 patients aged 55-87 years with a diagnosis of cancer. Participants received 7 days of APA treatment for their pain. After appropriate acupoints were identified, vaccaria seeds were carefully taped onto each selected auricular point on each ear. The study recruitment and retention rates were 92% and 91%, respectively. Importantly, the study found preliminary evidence for the analgesic effects of APA for cancer pain management. For example, by the end of the 7-day study, APA reduced pain intensity more than 55% for "worst pain" and about 57% for "average pain" and "pain intensity." Moreover, the use of pain medication was reduced during the APA treatment (e.g., 78% of patients [n = 39] took less pain medication than before the treatment). APA appears to be highly acceptable to patients with cancer-related pain. However, without a placebo control, we cannot draw conclusive evidence for the analgesic effect of APA for cancer patients. A sham group must be added to future studies to differentiate the true effects of APA from the possible psychological effects of the APA treatment. PMID:25439120

  9. Alkaline Phosphatase Activity : an overlooked player on the phosphate behavior in macrotidal estuaries

    Science.gov (United States)

    Delmas, Daniel; Labry, Claire; Youenou, Agnes; Quere, Julien; Auguet, Jean Christophe; Montanie, Helene

    2014-05-01

    The non-conservative behavior of phosphate within the estuarine salinity gradient is essentially assigned to physico-chemical processes, such as desorption at low salinity and to benthic exchanges. Microbial phosphatase activity (APA), generally related to phosphate deficiency, is seldom studied in phosphate rich estuarine waters. In order to address the impact of microbial activity (bacterial abundance, production BSP, APA) on phosphate behavior, we studied these activities on a seasonal basis within the salinity gradient of two macrotidal estuaries presenting different levels of suspended solids. Whatever the season the Charente estuary is characterized by high levels of Suspended Particulate Matter (SPM > 1g.L-1), particularly in the Maximum Turbidity Zone (MTZ) located at the 5-10 psu. In this area characterized by high BSP and APA there is a significant increase of PO4 levels especially during summer. In the Aulne estuary the particle load is significantly lower (1/10) but high BSP and APA are equally recorded. In the highly turbid waters of the Charente estuary, active phytoplankton is virtually absent as pheopigments constitute up to 80% of the total pigments, particularly in the MTZ, therefore APA may essentially have a bacterial origin. In the Aulne estuary attached bacteria are dominant, both in numbers and production, and their distribution along the haline gradient perfectly follows those of APA and phosphate levels. These observations, associated with the very close relationships observed between APA, SPM and BSP, suggest that APA derive mainly from bacterial (attached) origin and operate at the expense of particulate phosphorus and hence contribute to PO4 regeneration, especially in spring and summer. Finally, as APA increased as PO4, whereas the reverse is observed in both fresh and marine waters, an original scheme for APA regulation, related to the large dominance of attached bacteria can be described for the estuarine waters.

  10. Variations of alkaline phosphatase activity and P fractions in sediments of a shallow Chinese eutrophic lake (Lake Taihu)

    International Nuclear Information System (INIS)

    The distribution of alkaline phosphatase activity (APA) and P fractions in sediment cores and the relationship between them were studied in a shallow Chinese freshwater lake (Lake Taihu). Sediment cores were collected from four sites, characterized by different degrees of eutrophication in June 2004. Sediment P was fractionated into Fe/Al-P, Ca-P, organic P (OP), inorganic P (IP) and total P (TP). The former two species made the largest contribution to the sediment P pool. Results show that trophic status and hydrological conditions have great impact on the APA of the sediments. The order of the APA in sediments was conjectured to be: macrophyte dominated lake > transitional lake > algal dominated lake. APA profiles follow a similar downcore decreasing trend. There was a positive relationship between the APA and the TP, IP. The multiple linear regression equation of the APA and P fractions is: APA = -97 + 0.768TP - 0.985Fe/Al-P. - Characteristics of the alkaline phosphatase activity and P fractions in sediments of different trophic status lake were studied in Lake Taihu

  11. Protocol to assess the neurophysiology associated with multi-segmental postural coordination

    International Nuclear Information System (INIS)

    Anticipatory postural adjustments (APAs) stabilize potential disturbances to posture caused by movement. Impaired APAs are common with disease and injury. Brain functions associated with generating APAs remain uncertain due to a lack of paired tasks that require similar limb motion from similar postural orientations, but differ in eliciting an APA while also being compatible with brain imaging techniques (e.g., functional magnetic resonance imaging; fMRI). This study developed fMRI-compatible tasks differentiated by the presence or absence of APAs during leg movement. Eighteen healthy subjects performed two leg movement tasks, supported leg raise (SLR) and unsupported leg raise (ULR), to elicit isolated limb motion (no APA) versus multi-segmental coordination patterns (including APA), respectively. Ground reaction forces under the feet and electromyographic activation amplitudes were assessed to determine the coordination strategy elicited for each task. Results demonstrated that the ULR task elicited a multi-segmental coordination that was either minimized or absent in the SLR task, indicating that it would serve as an adequate control task for fMRI protocols. A pilot study with a single subject performing each task in an MRI scanner demonstrated minimal head movement in both tasks and brain activation patterns consistent with an isolated limb movement for the SLR task versus multi-segmental postural coordination for the ULR task. (note)

  12. Alaska Power Administration combined financial statements, schedules, and supplemental reports, September 30, 1997 and 1996 with independent auditors` report thereon

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The Alaska Power Administration (APA) will continue to encourage economic and industrial development in Alaska through implementing the sale of APA assets in a manner consistent with the authorizing legislation while balancing all the stakeholders` interests. Alaska Power Administration will provide their employees opportunities for successful career transitions and conduct an efficient transfer of assets and closeout of APA, while continuing to provide customers reliable, low-cost hydroelectric energy during the transition. The attached report presents the results of the independent certified public accounts` audit of the Alaska Power Administration`s (APA) combined power system statements of assets; Federal investment and liabilities; and the related combined statements of revenues, expenses and accumulated net revenues, and cash flows. The auditors` reports on APA`s internal control structure and compliance with laws and regulations disclosed no reportable conditions or instances of noncompliance. Based on the unqualified opinion of the independent public accounting firm of KPMG Peak Marwick LLP and review of their audit work, the authors believe the financial statements fairly present the financial condition and results of the operations of APA for the period under audit.

  13. Characterising antimicrobial protein-membrane complexes

    International Nuclear Information System (INIS)

    Full text: Antimicrobial proteins (AMPs) are host defence molecules that protect organisms from microbial infection. A number of hypotheses for AMP activity have been proposed which involve protein membrane interactions. However, there is a paucity of information describing AMP-membrane complexes in detail. The aim of this project is to characterise the interactions of amoebapore-A (APA-1) with membrane models using primarily solution-state NMR spectroscopy. APA-1 is an AMP which is regulated by a pH-dependent dimerisation event. Based on the atomic resolution solution structure of monomeric APA-1, it is proposed that this dimerisation is a prerequisite for ring-like hexameric pore formation. Due to the cytotoxicity of APA-1, we have developed a cell-free system to produce this protein. To facilitate our studies, we have adapted the cell-free system to isotope label APA-1. 13C/15N-enriched APA-1 sample was achieved and we have begun characterising APA-1 dimerisation and membrane interactions using NMR spectroscopy and other biochemical/biophysical methods. Neutron reflectometry is a surface-sensitive technique and therefore represents an ideal technique to probe how APA-1 interacts with membranes at the molecular level under different physiological conditions. Using Platypus, the pH-induced APA-1-membrane interactions should be detectable as an increase of the amount of protein adsorbed at the membrane surface and changes in the membrane properties. Specifically, detailed information of the structure and dimensions of the protein-membrane complex, the position and amount of the protein in the membrane, and the perturbation of the membrane phospholipids on protein incorporation can be extracted from the neutron reflectometry measurement. Such information will enable critical assessment of current proposed mechanisms of AMP activity in bacterial membranes and complement our NMR studies

  14. p-Aminophenylacetic acid-mediated synthesis of monodispersed titanium oxide hybrid microspheres in ethanol solution.

    Science.gov (United States)

    Zhang, Hongye; Xie, Yun; Liu, Zhimin; Tao, Ranting; Sun, Zhenyu; Ding, Kunlun; An, Guimin

    2009-10-15

    Monodispersed TiO2 hybrid microspheres were prepared via the hydrolysis of titanium isopropoxide (TTIP) in ethanol solution containing p-aminophenylacetic acid (APA). The effects of the APA:TTIP molar ratio, water content, reaction time and reaction temperature on the morphology of the resultant spheres were investigated. The products were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction. It was demonstrated that the diameters of the resultant TiO2 spheres could be tuned in the range of 380-800 nm by changing the APA:TTIP molar ratio (1:3 to 3:1) and water content (1-3 v/v%) in the reaction medium, and that increasing the APA:TTIP molar ratio led to larger TiO2 hybrid spheres while increasing the water content decreased their size. The loading content of APA in the hybrid spheres could reach 20 wt.% as they were prepared with the APA:TTIP ratio of 3:1. The possible formation mechanism of the hybrid spheres was also investigated. It was found that APA slowed down the hydrolysis rate of the titanium precursor so that resulted in the formation of the TiO2 spheres. In addition, the APA present in TiO2 spheres acted as a reducing agent to in situ convert HAuCl4 into metallic Au on the surface of the TiO2 spheres. The catalytic activity of the resultant Au/APA-TiO2 composite was examined using transfer hydrogenation of phenylacetone with 2-propanol, and it was indicated that the catalyst displayed high efficiency for this reaction. PMID:19616218

  15. Alkaline phosphatase activity related to phosphorus stress of microphytoplankton in different trophic conditions

    Science.gov (United States)

    Ivančić, Ingrid; Pfannkuchen, Martin; Godrijan, Jelena; Djakovac, Tamara; Marić Pfannkuchen, Daniela; Korlević, Marino; Gašparović, Blaženka; Najdek, Mirjana

    2016-08-01

    The northern Adriatic (NA) is a favorable basin for studying the adaptive strategies of plankton to a variety of conditions along the steep gradients of environmental parameters over the year. Earlier studies identified phosphorus (P)-limitation as one of the key stresses within the NA that shape the biological response in terms of biodiversity and metabolic adjustments. A wide range of reports supports the notion that P-limitation is a globally important phenomenon in aquatic ecosystems. In this study P stress of marine microphytoplankton was determined at species level along a trophic gradient in the NA. In P-limitation all species with considerable contributions to the diatom community expressed alkaline phosphatase activity (APA), compared to only a few marginal dinoflagellate species. Nevertheless, APA expressing species did not always dominate the phytoplankton community, suggesting that APA is also an important strategy for species to survive and maintain active metabolism outside of their mass abundances. A symbiotic relationship could be supposed for diatoms that did not express APA themselves and probably benefited from APA expressed by attached bacteria. APA was not expressed by any microphytoplankton species during the autumn when P was not limiting, while most of the species did express APA during the P-limitation. This suggests that APA expression is regulated by orthophosphate availability. The methods employed in this study allowed the microscopic detection of APA for each microphytoplankton cell with simultaneous morphologic/taxonomic analysis. This approach uncovered a set of strategies to compete in P-limited conditions within the marine microphytoplankton community. This study confirms the role of P-limitation as a shaping factor in marine ecosystems.

  16. Alterations in polyadenylation and its implications for endocrine disease

    DEFF Research Database (Denmark)

    Rehfeld, Anders Aagaard; Plass, Mireya; Krogh, Anders;

    2013-01-01

    Introduction: Polyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation. Genes with multiple poly(A) sites can undergo alternative polyadenylation (APA), producing distinct mRNA isoforms with...... different 3' untranslated regions (3' UTRs) and in some cases different coding regions. Two thirds of all human genes undergo APA. The efficiency of the polyadenylation process regulates gene expression and APA plays an important part in post-transcriptional regulation, as the 3' UTR contains various cis...

  17. Unions and Upward Mobility for Asian Pacific American Workers

    OpenAIRE

    John Schmitt; Hye-Jin Rho; Nicole Woo

    2009-01-01

    Asian Pacific American (APA) workers are, with Latinos, the fastest growing group in the U.S. workforce and in organized labor. Since the late 1980s, APA workers have seen their representation in the ranks of U.S. unions almost double, from about 2.5 percent of all union workers in 1989 to about 4.6 percent in 2008. This report uses national data from the Current Population Survey (CPS) to show that unionization raises the wages of the typical APA worker by 9 percent compared to their non-uni...

  18. Responding to change in a challenging climate: 2015 five-year report of the Policy and Planning Board.

    Science.gov (United States)

    2016-01-01

    The American Psychological Association (APA) Bylaws Article XI.7 (http://www.apa.org/about/governance/bylaws/article-11.aspx) requires that the Policy and Planning Board report annually by publication to the membership and review the structure and function of the association as a whole every fifth year. This report details the board's 5-year review, including APA's challenges and achievements from 2011 through 2015 within the context of broader social and environmental changes. Recommended priorities for future change are offered. (PsycINFO Database Record PMID:27504574

  19. On-orbit operations of the Space Station Freedom attached payloads accommodations equipment

    Science.gov (United States)

    Lane, Jean Folse; Stivaletti, Joseph

    1989-01-01

    The Space Station Freedom which will serve as a base of operations for instruments performing space science is discussed. The Attached Payload Accommodation Equipment (APAE) will be a set of equipment designed to provide standard structural, power, data and thermal interfaces between payloads and the space station. The APAE is designed to minimize and simplify the on-orbit operations required for payload installation, replacement, and servicing. In addition, the APAE supplies launch support for small payloads and attitude control for payloads that required it.

  20. UPF2-dependent nonsense-mediated mRNA decay pathway is essential for spermatogenesis by selectively eliminating longer 3'UTR transcripts

    DEFF Research Database (Denmark)

    Bao, Jianqiang; Vitting-Seerup, Kristoffer; Waage, Johannes Eichler;

    2016-01-01

    During transcription, most eukaryotic genes generate multiple alternative cleavage and polyadenylation (APA) sites, leading to the production of transcript isoforms with variable lengths in the 3' untranslated region (3'UTR). In contrast to somatic cells, male germ cells, especially pachytene...

  1. Antiphospholipid Antibody and Antiphospholipid Syndrome

    Institute of Scientific and Technical Information of China (English)

    吴竞生

    2008-01-01

    @@ Antiphospholipid antibodies (APA) APA is a big category for all kinds of negative charge phospholipid or lecithin - a protein complex autoantibodies or the same antibody, through its recognition of antigen (target protein) different, and phospholipids or lecithin - protein complex combination of various rely on the interference Phospholipid clotting and anti-coagulation factor, and promote endothelial cells, platelets, complement activation and play a role. APA including lupus anticoagulant(LA) and anticardiolipin antibody (ACA), In addition, there are anti-β2 glycoprotein-I (β2-GPI) antibody, anti-prothrombin (a- PT) antibody, anti-lysophosphatidic acid antibody and anti-phosphatidylserine antibody, and so on. APA as the main target of phospholipid-binding protein, including β2-GPI, prothrombin, annexin, protein C (PC) and protein S (PS), plasminogen, and so on.

  2. Estonian President Ilves: Euro introduction was a "fantastic idea"

    Index Scriptorium Estoniae

    2011-01-01

    President Toomas Hendrik Ilves nõudis Viinis maailmapoliitika konverentsi ajal uudisteagentuurile APA antud usutluses rangemat rahanduspoliitilist distsipliini.Visiit Šveitsi ja Austriasse 07.12.2011 - 11.12.2011

  3. YPEL4 modulates HAC15 adrenal cell proliferation and is associated with tumor diameter.

    Science.gov (United States)

    Oki, Kenji; Plonczynski, Maria W; Gomez-Sanchez, Elise P; Gomez-Sanchez, Celso E

    2016-10-15

    Yippee-like (YPEL) proteins are thought to be related to cell proliferation because of their structure and location in the cell. The aim of this study was to clarify the effects of YPEL4 on aldosterone production and cell proliferation in the human adrenocortical cell line (HAC15) and aldosterone producing adenoma (APA). Basal aldosterone levels in HAC15 cells over-expressing YPEL4 was higher than those of control HAC15 cells. The positive effects of YPEL4 on cell proliferation were detected by XTT assay and crystal violet staining. YPEL4 levels in 39 human APA were 2.4-fold higher compared to those in 12 non-functional adrenocortical adenomas, and there was a positive relationship between YPEL4 levels and APA diameter (r = 0.316, P APA in humans. PMID:27333825

  4. A Comparison of DSM-IV and DSM-5 Panel Members' Financial Associations with Industry: A Pernicious Problem Persists

    OpenAIRE

    Cosgrove, Lisa; Krimsky, Sheldon

    2012-01-01

    Lisa Cosgrove and Sheldon Krimsky examine the new competing interest disclosure policy of the American Psychiatric Association (APA) and report that DSM panel members still have considerable financial conflicts of interest.

  5. Two-Thirds of Americans Report Daily Discrimination in Poll

    Science.gov (United States)

    ... to race, ethnicity, age, disability, gender or sexual orientation," Jaime Diaz-Granados, executive director for education at the American Psychological Association (APA), said in a news release from ...

  6. 33 CFR 1.05-35 - Notice of proposed rulemaking (NPRM).

    Science.gov (United States)

    2010-07-01

    ... Administrative Procedure Act (APA), 5 U.S.C. 553, an NPRM is generally published in the Federal Register for... discussion of any comments received in response to prior notices, a citation of legal authority for the...

  7. The PsycARTICLES database: attributes and limitations.

    Science.gov (United States)

    Piotrowski, Chris; Perdue, Bob

    2003-12-01

    This paper presents an overview on the main features of the new APA database, PsycARTICLES, with a focus on the citation searching option. Both positive aspects and limitations of the file are noted. PMID:14738369

  8. Citation Styles For Internet Resources : A Webliography

    Directory of Open Access Journals (Sweden)

    2004-12-01

    Full Text Available A Webliography collects resources about citation Styles For internet resources, it divided by the styles: Chicago University style, MLA style, APA style, ISO style, and some articles about internet resources citation.

  9. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Association for Emergency Psychiatry Association of Gay and Lesbian Psychiatrists Resources Explore More Topics Warning Signs of ... APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Terms of Use Copyright Contact © 2016 American Psychiatric ...

  10. New Perspectives on Rodent Models of Advanced Paternal Age: Relevance to Autism

    Directory of Open Access Journals (Sweden)

    Claire J Foldi

    2011-06-01

    Full Text Available Offspring of older fathers have an increased risk of various adverse health outcomes, including autism and schizophrenia. With respect to biological mechanisms for this association, there are many more germline cell divisions in the life history of a sperm relative to that of an oocyte. This leads to more opportunities for copy error mutations in germ cells from older fathers. Evidence also suggests that epigenetic patterning in the sperm from older men is altered. Rodent models provide an experimental platform to examine the association between paternal age and brain development. Several rodent models of advanced paternal age (APA have been published with relevance to intermediate phenotypes related to autism. All four published APA models vary in key features creating a lack of consistency with respect to behavioural phenotypes. A consideration of common phenotypes that emerge from these APA-related mouse models may be informative in the exploration of the molecular and neurobiological correlates of APA.

  11. What Is Psychiatry?

    Medline Plus

    Full Text Available ... Us Newsroom News Releases Message from the President Reporting on Mental Health Conditions APA Blogs Advocacy & APAPAC ... choose additional training in psychoanalysis or in psychiatric research. Where Do Psychiatrists Work? Psychiatrists work in a ...

  12. Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis

    DEFF Research Database (Denmark)

    Brandt, Christian; Frimodt-Moller, N; Lundgren, Jens Dilling;

    2006-01-01

    OBJECTIVE: Bacteraemia concomitant with meningitis has been shown to greatly affect outcome. Consequently, the efficacy of serotype-specific anti-pneumococcal antiserum (APAS) was investigated in a rat model of pneumococcal meningitis. METHODS: Rats were infected with Streptococcus pneumoniae...... serotype 3. All rats received ceftriaxone starting 26 h post-infection. APAS was administered either at the time of infection or 26 h post-infection and effects were compared with rats treated with antibiotics only. RESULTS AND CONCLUSION: A significant clinical benefit was found when APAS was given at the...... time of infection whereas no effect was found when administered 26 h after infection. This work indicates that the clinical value of using APAS in pneumococcal meningitis may be limited...

  13. Homosexuality: Facts for Teens

    Science.gov (United States)

    ... Researchers who study human sexuality believe that sexual orientation develops and changes over a person’s lifetime. Having ... All major mental health organizations, including the American Psychological Association (APA), have stated that homosexuality is not ...

  14. Probability as certainty: dichotomous thinking and the misuse of p values.

    Science.gov (United States)

    Hoekstra, Rink; Finch, Sue; Kiers, Henk A L; Johnson, Addie

    2006-12-01

    Significance testing is widely used and often criticized. The Task Force on Statistical Inference of the American Psychological Association (TFSI, APA; Wilkinson & TFSI, 1999) addressed the use of significance testing and made recommendations that were incorporated in the fifth edition of the APA Publication Manual (APA, 2001). They emphasized the interpretation of significance testing and the importance of reporting confidence intervals and effect sizes. We examined whether 286 Psychonomic Bulletin & Review articles submitted before and after the publication of the TFSI recommendations by APA complied with these recommendations. Interpretation errors when using significance testing were still made frequently, and the new prescriptions were not yet followed on a large scale. Changing the practice of reporting statistics seems doomed to be a slow process. PMID:17484431

  15. Help your teen cope with stress

    Science.gov (United States)

    ... situations on their own. Stock up on healthy foods. Like many adults, teens often reach for unhealthy snacks when they are ... Accessed April 21, 2014. American Psychological Association. Are ... Stress Habits? February 2014. Available at: www.apa.org/news/ ...

  16. Help With Bipolar Disorders

    Science.gov (United States)

    ... a Psychiatrist Patients & Families All Topics Help With Bipolar Disorders Curated and updated for the community by APA Topic Information Bipolar disorders are brain disorders that cause changes in a ...

  17. Depression - resources

    Science.gov (United States)

    Resources - depression ... Depression is a medical condition. If you think you may be depressed, see a health care provider. ... following organizations are good sources of information on depression : American Psychological Association -- www.apa.org/topics/depress/ ...

  18. Answers to Your Questions about Transgender Individuals and Gender Identity

    Science.gov (United States)

    ... Questions for a Better Understanding of Sexual Orientation & Homosexuality for more information on sexual orientation). The degree ... questions for a better understanding of sexual orientation & homosexuality. Retrieved from http: / / www. apa. org/ topics/ lgbt/ ...

  19. Help With Schizophrenia

    Science.gov (United States)

    ... trouble with thinking and concentration, and lack of motivation. However, when these symptoms are treated, most people ... Learning Center APA Annual Meeting Psychiatric News PsychiatryOnline Workplace Mental Health Terms of Use Copyright Contact © 2016 ...

  20. Diagnosis and treatment of atypical polypoid adenomyoma of uterus%子宫非典型息肉样腺肌瘤诊治分析

    Institute of Scientific and Technical Information of China (English)

    叶明侠; 彭红梅; 黄柯; 李立安; 孟元光; 李亚里

    2013-01-01

    Objective To study the clinical characteristics, diagnosis and treatment of atypical polypoid adenomyoma (APA) of uterus. Methods Clinical data about 13 patients with APA of uterus admitted to our hospital from January 2006 to October 2011 were retrospectively analyzed. Results APA usually occurred in premenopausal women and mainly manifested as irregular menstrual bleeding and infertility. Of the 13 patients, 6 underwent total hysterectomy and were followed up for 67 months during which no abnormality was observed, 5 received hysteroscopic tumor resection and curettage, 3 was pathologically diagnosed with APA and received no further treatment, 2 was pathologically diagnosed with low malignant potential APA and treated with progestogen with relapse in 1 who was not pregnant after treatment. No malignancy was found in all patients. Conclusion APA is a benign tumor with a good prognosis. It may potentially become malignant and can be surgically removed with fertility reserved and treated with progestogen. APA patients should be regularly followed up. Surgery and hysteroscopy are recommended for its reexamination.%  目的探讨子宫非典型息肉样腺肌瘤(atypical polypoid adenomyoma,APA)的临床特点、诊断及治疗.方法回顾性分析我院2006年1月-2011年10月住院治疗的13例APA患者临床诊疗情况及结局.结果 APA多发于绝经前,主要临床表现为不规则阴道流血及不孕.6例全子宫切除患者,随访至今,最长67个月,定期复查未见异常.5例宫腔镜下肿物切除+诊刮患者,3例病理为APA,未行进一步治疗,单纯随访未见异常.2例病理为低恶性潜能APA(atypical polypoid adenomyoma of low malignant potential,APA-LMP),给予孕激素治疗,其中1例复发,均给予助孕治疗,尚未妊娠.所有患者无恶变.结论 APA是一种良性病变,多数预后良好;但有恶性潜能,可以行保留生育功能的手术,同时辅以孕激素治疗,严格随诊;手术及复查推荐宫腔镜.

  1. Economic Needs of Asian Americans and Pacific Islanders in Distressed Areas: Establishing Baseline Information

    OpenAIRE

    Ong, Paul M.; Miller, Douglas

    2002-01-01

    This report provides baseline statistics needed for policy-oriented research on disadvantaged Asian-Pacific Americans (APAs) neighborhoods. We profile 17 poor APA neighborhoods across the United States and provide insights from a survey of community-based organizations (CBOs). The neighborhood profiles reveal diverse neighborhood characteristics, including variations in economic base, size, and ethnic composition. In spite of substantial differences, some common features are seen. Most neighb...

  2. Economic Needs of Asian Americans and Pacific Islanders in Distressed Areas: Establishing Baseline Information

    OpenAIRE

    Ong, Paul M.; Miller, Douglas

    2002-01-01

    This report provides baseline statistics needed for policy-oriented research on disadvantaged Asian-Pacific Americans (APAs) neighborhoods. We profile 17 poor APA neighborhoods across the United States and provide insights from a survey of community-based organizations (CBOs). The neighborhood profiles reveal diverse neighborhood characteristics, including variations in economic base, size, and ethnic composition. In spite of substantial differences, some common features are seen. Most nei...

  3. Changes of pain behavior and expression of N-methyl-D-aspartate receptor in spinal dorsal horn after intrathecal transplantation of microcapsulized transplant-enkephalin cells in rat%鞘内移植微囊化转前脑啡肽原基因细胞对大鼠痛行为及脊髓背角相关蛋白表达的影响

    Institute of Scientific and Technical Information of China (English)

    曹靖; 王振全; 任秀花; 臧卫东

    2010-01-01

    目的:观察海藻酸钠-聚赖氨酸-海藻酸钠(APA)微囊化转鼠前脑啡肽原基因NIH3T3细胞(APA-NIH3T3/rPENK)移植对大鼠神经痛的影响及相关机制.方法:制作SD大鼠坐骨神经慢性压迫模型(CCI),随机分为APA空囊组、NIH3T3/rPENK组和APA-NIH3T3/rPENK组.测定移植后各组CCI术侧热痛阈,大鼠脊髓背角N-甲基-D-天冬氨酸受体2B亚基(NR2B)蛋白的表达情况.结果:移植后NIH3T3/rPENK组和APA-NIH3T3/rPENK组热痛阈明显高于APA空囊组.移植15d后APA-NIH3T3/rPENK组热痛阈显著高于NIH3T3/rPEN组.NIH3T3/rPENK组、 APA-NIH3T3/rPENK组结扎侧背角NR2B蛋白表达低于APA组;APA-NIH3T3/rPENK组背角NR2B蛋白表达低于NIH3T3/rPENK组.结论:NIH3T3/RPENK或APA-NIH3T3/rPENK植入大鼠的蛛网膜下腔可以明显减轻神经痛大鼠的热痛敏感行为,并降低脊髓背角NR2B蛋白的表达.

  4. A case of bilateral aldosterone-producing adenomas differentiated by segmental adrenal venous sampling for bilateral adrenal sparing surgery.

    Science.gov (United States)

    Morimoto, R; Satani, N; Iwakura, Y; Ono, Y; Kudo, M; Nezu, M; Omata, K; Tezuka, Y; Seiji, K; Ota, H; Kawasaki, Y; Ishidoya, S; Nakamura, Y; Arai, Y; Takase, K; Sasano, H; Ito, S; Satoh, F

    2016-06-01

    Primary aldosteronism due to unilateral aldosterone-producing adenoma (APA) is a surgically curable form of hypertension. Bilateral APA can also be surgically curable in theory but few successful cases can be found in the literature. It has been reported that even using successful adrenal venous sampling (AVS) via bilateral adrenal central veins, it is extremely difficult to differentiate bilateral APA from bilateral idiopathic hyperaldosteronism (IHA) harbouring computed tomography (CT)-detectable bilateral adrenocortical nodules. We report a case of bilateral APA diagnosed by segmental AVS (S-AVS) and blood sampling via intra-adrenal first-degree tributary veins to localize the sites of intra-adrenal hormone production. A 36-year-old man with marked long-standing hypertension was referred to us with a clinical diagnosis of bilateral APA. He had typical clinical and laboratory profiles of marked hypertension, hypokalaemia, elevated plasma aldosterone concentration (PAC) of 45.1 ng dl(-1) and aldosterone renin activity ratio of 90.2 (ng dl(-1) per ng ml(-1 )h(-1)), which was still high after 50 mg-captopril loading. CT revealed bilateral adrenocortical tumours of 10 and 12 mm in diameter on the right and left sides, respectively. S-AVS confirmed excess aldosterone secretion from a tumour segment vein and suppressed secretion from a non-tumour segment vein bilaterally, leading to the diagnosis of bilateral APA. The patient underwent simultaneous bilateral sparing adrenalectomy. Histopathological analysis of the resected adrenals together with decreased blood pressure and PAC of 5.2 ng dl(-1) confirmed the removal of bilateral APA. S-AVS was reliable to differentiate bilateral APA from IHA by direct evaluation of intra-adrenal hormone production. PMID:26538381

  5. McCay Vernon: award for distinguished senior career contributions to psychology in the public interest.

    Science.gov (United States)

    2006-11-01

    Presents a citation for McCay Vernon, who received the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest "for fifty-five years of distinguished contributions toward improving the lives of both deaf and deaf-blind individuals." Accompanying the citation are a brief profile and a selected bibliography, as well as Vernon's award address, The APA and Deafness. ((c) 2006 APA, all rights reserved). PMID:17115822

  6. Covalent functionalization of graphene oxide by 9-(4-aminophenyl)acridine and its derivatives

    Institute of Scientific and Technical Information of China (English)

    Yi Si Feng; Jing Jing Ma; Xin Yan Lin; Jia Song Zhang; Peng Lv; Hua Jian Xu; Lin Bao Luo

    2012-01-01

    Graphene/acridine (G-Acr) hybrid structures were synthesized through covalent functionalization of graphene oxide with 9-(4-aminophenyl)acridine (APA) and its derivatives.The G-Acr hybrids were characterized by Fourier transform infrared spectroscopy,ultraviolet-visible spectrophotometry,thermal gravimetric analysis and Raman spectroscopy.X-ray photoelectron spectroscopy confirms that the binding energies of APA and its derivatives shifted to higher values,revealing pronounced charge transfer at the interface of graphene and organic molecules.

  7. Konsep Fiqah Malaysia dalam Perundangan Islam: Satu Pengenalan (The Concept of Malaysian Fiqah in Islamic Law: An Introduction)

    OpenAIRE

    Rahimin Affandi Abd. Rahim; Shamsiah Mohamad; Paizah Ismail; Nor Hayati Mohd Dahlal

    2010-01-01

    Kajian ini bertujuan untuk menunjukkan sifat dinamik konsep fiqah dalam sistem perundangan Islam Malaysia yang menekankan kepentingan hubungan dengan Allah dan sesama makhluk. Teori utama yang digunakan adalah teori epistemologi hukum Islam yang menetapkan bahawa sifat kelestarian sistem hukum Islam hanya boleh dicapai melalui pembentukan kerangka epistemologi (apa, bagaimana dan untuk tujuan apa) yang jelas. Bagi mencapai objektif, kajian ini menggunakan kaedah pengumpulan data primer dan da...

  8. Pioneers in Pediatric Psychology: Integrating Nutrition and Child Development Interventions

    OpenAIRE

    Black, Maureen M.

    2015-01-01

    As part of the Pioneers in Pediatric Psychology series, this article provides a brief personal account of Maureen Black's career as a pediatric psychologist. It traces the transition of the Society of Pediatric Psychology (SPP) from a section of the Division of Clinical Psychology of the American Psychological Association (APA) to an independent division of APA, which occurred during my presidency of SPP. The article addresses three aspects of pediatric psychology that have been central to my...

  9. Activation timing of soleus and tibialis anterior muscles during sit-to-stand and stand to sit in post-stroke vs healthy subjects

    OpenAIRE

    Augusta Silva; Andreia S. P. Sousa; Rita Pinheiro; Joana Ferraz; João Manuel R. S. Tavares; Rubim Santos; Filipa Sousa

    2013-01-01

    Introduction: Sit-to-stand (SitTS) and stand-to-sit (StandTS) are very important functional tasks that become compromised in stroke patients. As in other voluntary movements, they require an adequate postural control (PC) involving the generation of anticipatory postural adjustments (APAs). In order to give clues for more efficient and directed rehabilitation programs, a deeper knowledge about APAs during challenging and daily life movements is essential. Purpose: To analyze the activation ti...

  10. Persepsi Petani Mengenai Pupuk Palsu (Study kasus: Petani Jeruk Desa Surbakti, Kecamatan Simpang Empat, Kabupaten Karo)

    OpenAIRE

    Panjaitan, Reny Vesta Murtina

    2012-01-01

    Reaksi petani mengenai munculnya pupuk palsu : 50 % menyatakan tidak berbuat apa-apa 26,67 % Menghubungi distributor kembali dan 23,33 % tidak membeli pupuk di tempat yang sama. Pengalaman petani terhadap pemalsuan pupuk : 43,33 % menyatakan tidak pernah tertipu, 30 % pernah tertipu dan 26,67 % tidak tahu/tidak menyadari apakah pupuk yang dipakai palsu atau tidak. Pengetahuan petani terhadap pengenalan pupuk palsu : 70 % menyatakan sama sekali tidak tahu, dan 30 % menyatakan tahu berdasark...

  11. Alkaline phosphatase activity in the subtropical ocean: insights from nutrient, dust and trace metal addition experiments

    Directory of Open Access Journals (Sweden)

    Claire eMahaffey

    2014-12-01

    Full Text Available Phosphorus is an essential nutrient for all life on earth. In the ocean, the most bioavailable form of phosphorus is inorganic phosphate, but in the extensive subtropical gyres, phosphate concentrations can be chronically low and limit primary productivity and nitrogen fixation. In these regions, organisms produce hydrolytic enzymes, such as alkaline phosphatase (AP, that enable them to utilize the more replete dissolved organic phosphorus (DOP pool to meet their cellular phosphorus demands. In this study, we synthesized data from 14 published studies and present our own findings from two research cruises (D326 and D361 in the eastern subtropical Atlantic to explore the relationship between AP activity (APA and nutrients, Saharan dust and trace metals. We found that below a threshold phosphate concentration of ~ 30 nM, APA increased with an inverse hyperbolic relationship with phosphate concentration. Meanwhile, DOP concentrations decreased with enhanced APA, indicating utilization of the DOP pool. We found APA rates were significantly higher in the subtropical Atlantic compared to the subtropical Pacific Ocean, even over the same low phosphate concentration range (0 to 50 nM. While the phosphate concentration may have a first order control on the APA rates, we speculate that other factors influence this basin scale contrast. Using bioassay experiments, we show that the addition of Saharan dust and zinc significantly increased the rate of APA. To our knowledge, our results are the first direct field-based evidence that APA is limited by zinc in the subtropical ocean. Further work is required to explore the relationship between trace metals such as iron and zinc, which are co-factors of phosphohydrolytic enzymes, specifically PhoX and PhoA, respectively, and APA in the ocean.

  12. Reference List Errors in Manuscripts Submitted to a Journal for Review for Publication

    OpenAIRE

    Anthony J Onwuegbuzie; Eunjin Hwang

    2013-01-01

    Style errors outlined in the Publication Manual of the American Psychological Association (APA) were examined among 131 manuscripts submitted to Research in the Schools, a nationally refereed journal, over a 6-year period. Specifically, a mixed research design was utilized to determine the frequency and characteristics of APA errors committed in the reference lists of these manuscripts. Findings revealed that authors committed more than 12 reference list errors per manuscript, on average (M =...

  13. Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia.

    OpenAIRE

    Snapper, J R; Hinson, J M; Hutchison, A A; Lefferts, P L; Ogletree, M L; Brigham, K L

    1984-01-01

    The effect of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia was studied in eight unanesthetized sheep. Platelets were depleted with rabbit anti-sheep platelet antibodies (APA). Bolus injections of APA alone caused marked pulmonary hypertension (PPA increased from 21 +/- 2 to 62 +/- 5 cm H2O +/- SE) and alterations in lung mechanics (dynamic compliance of the lung [Cdyn] decreased to 38.5 +/- 4.6% and resistance to air flow across the lung [RL] increased to...

  14. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KESIAPAN KERJA SISWA KELAS XI ADMINISTRASI PERKANTORAN SMK N 1 PEMALANG

    OpenAIRE

    Karina Ajeng Softi,; Ade Rustiana; Nina Oktarina

    2012-01-01

    Tujuan Sekolah Menengah Kejuruan ialah menghasilkan lulusan yang siap kerja dan dapat mengembangkan sikap profesional. Namun, lulusan Sekolah Menengah Kejuruan belum seluruhnya dapat terjun dalam dunia kerja. Pemasalahan dalam skripsi ini yaitu faktor-faktor apa saja yang dapat mempengaruhi kesiapan kerja (studi kasus pada siswa kelas XI program keahlian administrasi perkantoran) di SMK Negeri 1 Pemalang dan faktor apa yang paling dominan pada siswa kelas XI program keahlian administrasi perk...

  15. An automatic method for inspecting plywood shear samples

    OpenAIRE

    Avent, R. Richard

    1990-01-01

    Plywood is composed of several thin layers of wood bonded together by glue. The adhesive integrity of the glue formulation employed must surpass the structural integrity of the wood species within a given panel of plywood. The American Plywood Association (APA) regularly tests the plywood produced at various plywood manufacturing plants to ensure that this particular performance requirement is consistently met. One of the procedures used by the APA to test this requirement c...

  16. Surface alkaline phosphatase activities of macroalgae on coral reefs of the central Great Barrier Reef, Australia

    Science.gov (United States)

    Schaffelke, B.

    2001-05-01

    Inshore reefs of the Great Barrier Reef (GBR) are subject to episodic nutrient supply, mainly by flood events, whereas midshelf reefs have a more consistent low nutrient availability. Alkaline phosphatase activity (APA) enables macroalgae to increase their phosphorus (P) supply by using organic P. APA was high (~4.0 to 15.5 µmol PO4 3- g DW-1 h-1) in species colonising predominantly inshore reefs and low (human activity, which currently is a global problem.

  17. Graduate Ethics Education: A Content Analysis of Syllabi

    OpenAIRE

    Grifith, Shannon M; Domenech Rodriguez, Melanie M.; Anderson, Austin J

    2014-01-01

    Ethical practice of psychology is emphasized by APA accreditation requirements. The current study is a content analysis of 53 ethics courses syllabi from all APA accredited programs listed in the American Psychologist 2011 annual report. This article is a companion to Domenech Rodríguez et al. (2013) and contributes knowledge on the current state of graduate ethics education. Of the parent project respondents (N = 364), 14% returned syllabi for the present study. General information (e.g., ob...

  18. Estimation of the parameters of cytotoxicity of fullerene C60 and C60-containing composites in vitro

    International Nuclear Information System (INIS)

    The influence of fullerene C60 and C60-containing composites (on the basis of aminopropylaerosyl (ApA)) on the stability of erythrocytes to acid haemolysis and the viability of thymocytes, ascite forms of Erlich and leucosis L1210 cells is studied. The obtained results indicate the possibility to use ApA as a matrix for conjugation with other elements and for the further biological studies of composites photosensitizing the effect

  19. ANALISIS PENGARUH KREDIBILITAS MEREK TERHADAP SENSITIVITAS HARGA KONSUMEN

    OpenAIRE

    Anik - Kusmintarti; Djasly - By; M Syafiie - Idrus

    2012-01-01

    ABSTRAKS   Informasi yang tidak sempurna dan tidak simetris mengakibatkan timbulnya ketidakpastian yang dihadapi konsumen tentang atribut dan/ atau manfaat apa yang didapat dari sebuah produk.  Dalam kondisi seperti ini penting bagi perusahaan untuk menyampaikan informasi terpercaya kepada konsumen, yaitu informasi yang jujur dan perusahaan harus bersedia dan mampu menyampaikan apa yang telah dijanjikan. Merek yang kredibel berpengaruh terhadap  kesan kualitas, resiko yang diterima dan biaya ...

  20. [Influence of paternal age in schizophrenia].

    OpenAIRE

    Hubert, Alexandre; Szöke, Andrei; Leboyer, Marion; Schürhoff, Franck

    2011-01-01

    International audience BACKGROUND: Schizophrenia is an aetiologically heterogeneous syndrome, with a strong genetic component. Despite a reduced fertility in this disorder, its prevalence is maintained and could be explained by de novo genetic mutations. Advanced paternal age (APA) is a major source of new mutations in human beings and could thus be associated with an increased risk of developing schizophrenia in offspring. New mutations related to APA have been implicated as a cause of sp...

  1. Preparatory state and postural adjustment strategies for choice reaction step initiation.

    Science.gov (United States)

    Watanabe, Tatsunori; Ishida, Kazuto; Tanabe, Shigeo; Nojima, Ippei

    2016-09-22

    A loud auditory stimulus (LAS) presented simultaneously with a visual imperative stimulus can reduce reaction time (RT) by automatically triggering a movement prepared in the brain and has been used to investigate a movement preparation. It is still under debate whether or not a response is prepared in advance in RT tasks involving choice responses. The purpose of the present study was to investigate the preparatory state of anticipatory postural adjustments (APAs) during a choice reaction step initiation. Thirteen young adults were asked to step forward in response to a visual imperative stimulus in two choice stepping conditions: (i) the responding side is not known and must be selected and (ii) the responding side is known but whether to initiate or inhibit a step response must be selected. LAS was presented randomly and simultaneously with the visual imperative stimulus. LAS significantly increased the occurrence rates of inappropriately initiated APAs while reducing the RTs of correct and incorrect trials in both task conditions, demonstrating that LAS triggered the prepared APA automatically. This observation suggests that APAs are prepared in advance and withheld from release until the appropriate timing during a choice reaction step initiation. The preparatory activity of APAs might be modulated by the inhibitory activity required by the choice tasks. The preparation strategy may be chosen for fast responses and is judged most suitable to comply with the tasks because inappropriately initiated APAs can be corrected without making complete stepping errors. PMID:27393247

  2. 改良APACHE评分系统对血栓性急症的临床应用

    Institute of Scientific and Technical Information of China (English)

    陈凯

    2008-01-01

    目的:探讨改良APA CHE评分系统对血栓性急症的临床应用.方法:采用改良APA CHEⅡ评分系统在急诊内科患者进行评分,根据分值分层比较各组缓解率、住院率和病死率,对生存组和死亡组的评分进行比较.结果:根据改良APA CHEⅡ评分进行分组后,随着改良APA CHEⅡ评分,病死率也逐渐升高,APA CHEⅡ评分均值高于急症组,差异具有统计学意义.结论:采用改良APA CHEⅡ评分系统对急诊内科患者评估,对血栓性急症能够判断病情和估计预后,而且简便、快捷,适合急诊应用.

  3. Kinetic studies on the carboxylation of 6-amino-penicillanic acid to 8-hydroxy-penillic acid

    DEFF Research Database (Denmark)

    Henriksen, Claus Maxel; Holm, SS; Schipper, D.;

    1997-01-01

    The carboxylation in aqueous solution of 6-amino-penicillanic acid (6-APA) to 8-hydroxy-penillic acid (8-HPA) was studied at 25 degrees C and pH 6.5. During sparging with either a citrate buffer or a chemically defined cultivation medium containing 6-APA with mixtures of carbon dioxide and air (2.......7-41% (v/v) CO2), the kinetics for conversion of 6-APA was followed by HPLC. In the citrate buffer 6-APA was converted by two competitive reactions each following first order kinetics with respect to the concentration of 6-APA: 1. carboxylation into 8-HPA; and 2. slow conversion into an unknown compound....... Formation of the unknown compound was not observed in the cultivation medium. The carboxylation of 6-APA was also found to be first order with respect to the concentration of dissolved carbon dioxide. The rate constant for formation of 8-HPA did not differ significantly in the cultivation medium compared to...

  4. The ethics of interrogation and the American Psychological Association: A critique of policy and process

    Directory of Open Access Journals (Sweden)

    Davis Martha

    2008-01-01

    Full Text Available Abstract The Psychological Ethics and National Security (PENS task force was assembled by the American Psychological Association (APA to guide policy on the role of psychologists in interrogations at foreign detention centers for the purpose of U.S. national security. The task force met briefly in 2005, and its report was quickly accepted by the APA Board of Directors and deemed consistent with the APA Ethics Code by the APA Ethics Committee. This rapid acceptance was unusual for a number of reasons but primarily because of the APA's long-standing tradition of taking great care in developing ethical policies that protected anyone who might be impacted by the work of psychologists. Many psychological and non-governmental organizations (NGOs, as well as reputable journalists, believed the risk of harm associated with psychologist participation in interrogations at these detention centers was not adequately addressed by the report. The present critique analyzes the assumptions of the PENS report and its interpretations of the APA Ethics Code. We demonstrate that it presents only one (and not particularly representative side of a complex set of ethical issues. We conclude with a discussion of more appropriate psychological contributions to national security and world peace that better respect and preserve human rights.

  5. Genome-Wide Association Study of Antiphospholipid Antibodies

    Directory of Open Access Journals (Sweden)

    M. Ilyas Kamboh

    2013-01-01

    Full Text Available Background. The persistent presence of antiphospholipid antibodies (APA may lead to the development of primary or secondary antiphospholipid syndrome. Although the genetic basis of APA has been suggested, the identity of the underlying genes is largely unknown. In this study, we have performed a genome-wide association study (GWAS in an effort to identify susceptibility loci/genes for three main APA: anticardiolipin antibodies (ACL, lupus anticoagulant (LAC, and anti-β2 glycoprotein I antibodies (anti-β2GPI. Methods. DNA samples were genotyped using the Affymetrix 6.0 array containing 906,600 single-nucleotide polymorphisms (SNPs. Association of SNPs with the antibody status (positive/negative was tested using logistic regression under the additive model. Results. We have identified a number of suggestive novel loci with PAPA. We have replicated the previously reported associations of HLA genes and APOH with APA but these were not the top loci. Conclusions. We have identified a number of suggestive novel loci for APA that will stimulate follow-up studies in independent and larger samples to replicate our findings.

  6. Engaging the recreational angling community to implement and manage aquatic protected areas.

    Science.gov (United States)

    Danylchuk, Andy J; Cooke, Steven J

    2011-06-01

    Recreational angling is a popular leisure activity, the quality of which is greatly dependent on fish abundance and well-functioning aquatic ecosystems. Aquatic protected areas (APAs) are used to help maintain and even restore aquatic systems and their associated biota, including fish species that are popular with recreational anglers. Paradoxically, the use of APAs has been a source of much contention and conflict between members of the recreational angling community and those interested in or mandated to protect aquatic resources on the basis of the interests of multiple stakeholder groups. The angling community is concerned about the loss of fishing opportunities and effectiveness of APAs. Although it is still unclear whether establishment of APAs alone can effectively protect aquatic resources, actively including the recreational angling community in the design, implementation, and management of APAs will help ensure the values of this rather substantial user group are incorporated into aquatic conservation strategies. Conversely, the probability of increasing the sustainability of recreational angling and related economies will be greatest if recreational angler groups remain open minded to both short-term and long-term goals of fisheries conservation strategies, including the use of APAs. PMID:21175844

  7. Amoebapore is an important virulence factor of Entamoeba histolytica

    Indian Academy of Sciences (India)

    Rivka Bracha; Yael Nuchamowitz; David Mirelman

    2002-11-01

    We have previously demonstrated that inhibition of expression of amoebapore A (AP-A) by antisense RNA caused a marked decrease in the virulence of the parasite. A four-fold over-expression of AP-A was obtained with plasmid (pA7) which has the ap-a gene under the control of gene EhgLE-3-RP-L21. The virulence of the transfected trophozoites, however, was also decreased. Excess of AP-A protein was found in the cytosol and a significant amount was released into the surrounding media. Transfection of the parasite with a plasmid (psAP-1) in which the ap-a gene was introduced with its own regulatory sequences, caused a total suppression of the transcription and translation of both the genomic and episomal ap-a genes. The silenced transfectant was not virulent at all. These results demonstrate that important factors need to be expressed at the correct cellular location and that the parasite has additional internal control mechanisms such as transcriptional gene silencing which can prevent excess amounts of gene expression.

  8. The ethics of interrogation and the American Psychological Association: a critique of policy and process.

    Science.gov (United States)

    Olson, Brad; Soldz, Stephen; Davis, Martha

    2008-01-01

    The Psychological Ethics and National Security (PENS) task force was assembled by the American Psychological Association (APA) to guide policy on the role of psychologists in interrogations at foreign detention centers for the purpose of U.S. national security. The task force met briefly in 2005, and its report was quickly accepted by the APA Board of Directors and deemed consistent with the APA Ethics Code by the APA Ethics Committee. This rapid acceptance was unusual for a number of reasons but primarily because of the APA's long-standing tradition of taking great care in developing ethical policies that protected anyone who might be impacted by the work of psychologists. Many psychological and non-governmental organizations (NGOs), as well as reputable journalists, believed the risk of harm associated with psychologist participation in interrogations at these detention centers was not adequately addressed by the report. The present critique analyzes the assumptions of the PENS report and its interpretations of the APA Ethics Code. We demonstrate that it presents only one (and not particularly representative) side of a complex set of ethical issues. We conclude with a discussion of more appropriate psychological contributions to national security and world peace that better respect and preserve human rights. PMID:18230171

  9. Should title lengths really adhere to the American Psychological Association's twelve word limit?

    Science.gov (United States)

    Hallock, Robert M; Dillner, Kari M

    2016-04-01

    The publication manual for the American Psychological Association (APA) suggests that title lengths do not exceed 12 words, yet journals do not prevent longer titles. Here, we examined title lengths in APA journals to see how many exceeded the APA's suggested limit. First, we conducted a systematic analysis of 235 articles in the current issues of 23 APA journals. A total of 52% of titles were more than 12 words long. Second, we examined articles from APA journals that were at least 50 years old to examine whether title lengths have changed over time. Our results suggested that the average title lengths have indeed increased with time. One of 2 courses should be taken. Perhaps science is becoming more complex that longer titles are needed in order to convey the primary message to the reader. If this is the case, then the APA's word limit should be increased. On the other hand, however, maybe editor and reviewers should try to enforce the current word limit to force writers to be succinct. Either way, editors should make their preferences clear so that the trend for longer titles does not continue unchecked. PMID:27042886

  10. [Antiphospholipid antibodies--antiphospholipid syndrome. Cause or consequence of thrombosis].

    Science.gov (United States)

    Scrobohaci, M L; Freyssinet, J M

    1991-09-01

    Antiphospholipid antibodies (APA) are heterogeneous immunoglobulines of G, M or A classes with specificity directed towards anionic phospholipids. The APA are associated with a wide variety of diseases. They have been found to represent risk factor for development of arterial and/or veinous thrombosis. The APA would perturbed the biological activities of anionic phospholipid surface in a manner that could decrease the natural anti-coagulant pathway in order to lead to thrombosis. In the latter hypothesis APA would appear as a secondary response to the exposure of phospholipid "self antigens" by activated or damaged blood vascular cells by known stimuli able to induce thrombosis. In these cases APA would therefore constitute a marker of risk of thrombosis. The question which remains to be solved is if APA possess their own pathogenic potential or if they appear as the result of an up-stream pathological event known to be favourable to the development of thrombosis or if both mechanism are involved. PMID:1758724

  11. Uterine arterial resistance index and auto-immune disease in patients with recurrent pregnancy loss%自身抗体阳性复发性自然流产患者的子宫动脉血流阻力变化

    Institute of Scientific and Technical Information of China (English)

    胡晶晶; 朱盈; 李国华; 洪向丽; 鲍时华; Joanne Kwak-Kim

    2015-01-01

    目的::研究自身抗体阳性的复发性自然流产(RPL)患者的子宫动脉血流阻力(U-RI)指数的变化。方法:回顾分析189例 RPL 患者(≥3)的临床资料,比较孕前自身抗体阳性和阴性患者的 U-RI 指数。结果:抗磷脂抗体(APA)阳性患者的 U-RI 明显高于APA 阴性组(P =0.018),APA-IgG 阳性组和 APA-IgA 阳性组的 U-RI 明显高于 APA 阴性组(P =0.015,P =0.030),APA-IgG、APA-IgA 阳性组的 U-RI 分别与 APA-IgG、APA-IgA 阴性组比较,差异有统计学意义(P =0.025,P =0.049),抗磷脂酸抗体(APAA)阳性组和抗磷脂酰肌醇抗体(APIA)阳性组的 U-RI 明显高于 APA 阴性组(P =0.045,P =0.048)。抗核抗体(ANA)阳性组和阴性组的 U-RI 比较,差异无统计学意义(P =0.235)。 ANA 阳性不同滴度和不同荧光核型组的 U-RI 比较,差异无统计学意义(P =0.384,P =0.181);其他抗体:anti-thyroid antibody(ATA)、dsDNA、ssDNA、Histone 及 Scl70阳性组和阴性组的 U-RI 比较,差异均无统计学意义(P>0.05)。结论:APA 阳性的 RPL 患者子宫动脉血流容易出现高阻,可能会引起子宫动脉血流灌注不足现象发生。%Objective:To investigate a possible relationship of uterine arterial resist-ance index ( U-RI) and auto-antibodies in women with recurrent pregnancy losses ( RPL).Methods:A retrospective medical record review was carried out in 189 women with RPL. Corre-lations between U-RIs and auto-antibodies were analyzed in women with RPL (≥3). Results:U-RIs were higher in RPL women with anti-phospholipid antibodies (APA) than those without APA (P =0. 018). U-RIs were higher in RPL women with APA-IgG and APA-IgA (P = 0. 015 and P =0. 030,respectively) as compared to those without APA. U-RIs of RPL women with pos-itive APA-IgG and APA-IgA were higher than those of negative APA-IgG and APA-IgA (P =0. 025 and P =0. 049,respectively). Significant differences in U-RIs were found in women with anti-phosphatidic acid antibody ( APAA) ( P = 0

  12. Interactive effects of temperature, ultraviolet radiation and food quality on zooplankton alkaline phosphatase activity.

    Science.gov (United States)

    Wolinski, Laura; Modenutti, Beatriz; Souza, Maria Sol; Balseiro, Esteban

    2016-06-01

    Ultraviolet Radiation (UVR) is a stressor for aquatic organisms affecting enzyme activities in planktonic populations because of the increase in reactive oxygen species. In addition, UVR exposure combined with other environmental factors (i.e. temperature and food quality) could have even higher detrimental effects. In this work, we aimed to determine the effect of UVR on somatic Alkaline Phosphatase Activity (APA) and Glutathione S-Transferase (GST) activity on the cladoceran Daphnia commutata under two different temperatures (10 °C and 20 °C) and under three food qualities (carbon:phosphorus ratios: 1150, 850 and 550). APA is a biomarker that is considered as a P deficiency indicator in zooplankton. Since recovery from UVR damage under dark conditions is an ATP depending reaction we also measured APA during recovery phases. We carried out a laboratory experiment combining different temperatures and food qualities with exposition to UVR followed by luminic and dark phases for recovery. In addition, we exposed organisms to H2O2, to establish if the response on APA to UVR was a consequence of the reactive oxygen species produced these short wavelengths. Our results showed that somatic APA was negatively affected by UVR exposure and this effect was enhanced under high temperature and low food quality. Consistently, GST activity was higher when exposed to UVR under both temperatures. The H2O2 experiments showed the same trend as UVR exposure, indicating that APA is affected mainly by oxidative stress than by direct effect of UVR on the enzyme. Finally, APA was affected in the dark phase of recovery confirming the P demands. These results enlighten the importance of food quality in the interacting effect of UVR and temperature, showing that C:P food ratio could determine the success or failure of zooplanktonic populations in a context of global change. PMID:26895537

  13. Responses of Soil Acid Phosphomonoesterase Activity to Simulated Nitrogen Deposition in Three Forests of Subtropical China

    Institute of Scientific and Technical Information of China (English)

    HUANG Wen-Juan; LIU Shi-Zhong; CHU Guo-Wei; ZHANG De-Qiang; LI Yue-Lin; LU Xian-Kai; ZHANG Wei; HUANG Juan; D. OTIENO; Z. H. XU; LIU Ju-Xiu

    2012-01-01

    Soil acid phosphomonoesterase activity (APA) plays a vital role in controlling phosphorus (P) cycling and reflecting the current degree of P limitation Responses of soil APA to elevating nitrogen (N) deposition are important because of their potential applications in addressing the relationship between N and P in forest ecosystems.A study of responses of soll APA to simulated N deposition was conducted in three succession forests of subtropical China.The three forests include a Masson pine (Pinus massoniana) forest (MPF)—pioneer community,a coniferous and broad-leaved mixed forest (MF)—transition community and a monsoon evergreen broadleaved forest (MEBF)—climax community.Four N treatments were designed for MEBF:control (without N added),low-N (50 kg N ha-1 year-1),and medium-N (100 kg N ha-1 year-1) and high-N (150 kg N ha-1 year-1),and only three N treatments (i.e.,control,low-N,mediun-N) were established for MPF and MF.Results showed that soil APA was highest in MEBF.followed by MPF and MF.Soil APAs in both MPF and MF were not influenced by low-N treatments but depressed in medium-N trcatments.However,soil APA in MEBF exhibited negative responses to high N additions,indicating that the environment of enhanced N depositions would reduce P supply for the mature forest ecosystem.Soil APA and its responses to N additions in subtropical forests were closely related to the succession stages in the forests.

  14. Detection of anticipatory postural adjustments prior to gait initiation using inertial wearable sensors

    Directory of Open Access Journals (Sweden)

    Sekine Masaki

    2011-04-01

    Full Text Available Abstract Background The present study was performed to evaluate and characterize the potential of accelerometers and angular velocity sensors to detect and assess anticipatory postural adjustments (APAs generated by the first step at the beginning of the gait. This paper proposes an algorithm to automatically detect certain parameters of APAs using only inertial sensors. Methods Ten young healthy subjects participated in this study. The subjects wore an inertial unit containing a triaxial accelerometer and a triaxial angular velocity sensor attached to the lower back and one footswitch on the dominant leg to detect the beginning of the step. The subjects were standing upright on a stabilometer to detect the center of pressure displacement (CoP generated by the anticipatory adjustments. The subjects were asked to take a step forward at their own speed and stride length. The duration and amplitude of the APAs detected by the accelerometer and angular velocity sensors were measured and compared with the results obtained from the stabilometer. The different phases of gait initiation were identified and compared using inertial sensors. Results The APAs were detected by all of the sensors. Angular velocity sensors proved to be adequate to detect the beginning of the step in a manner similar to the footswitch by using a simple algorithm, which is easy to implement in low computational power devices. The amplitude and duration of APAs detected using only inertial sensors were similar to those detected by the stabilometer. An automatic algorithm to detect APA duration using triaxial inertial sensors was proposed. Conclusions These results suggest that the feasibility of accelerometers is improved through the use of angular velocity sensors, which can be used to automatically detect and evaluate APAs. The results presented can be used to develop portable sensors that may potentially be useful for monitoring patients in the home environment, thus

  15. Alkaline phosphatase activity at the southwest coast of India: A comparison of locations differently affected by upwelling

    Science.gov (United States)

    Mamatha, S. S.; Malik, Ashish; Varik, Sandesh; Parvathi, V.; Jineesh, V. K.; Gauns, Mangesh U.; LokaBharathi, P. A.

    2015-01-01

    The realization of the potential importance of phosphorus (P) as a limiting nutrient in marine ecosystem is increasing globally. Hence, the contribution of biotic variables in mobilizing this nutrient would be relevant especially in productive coastal waters. As alkaline phosphatase activity (APA) indicates the status of P for primary production in aquatic environments, we asked the following question: is the level of APA indicative of P sufficiency or deficiency in coastal waters, especially, where upwelling is a regular phenomenon? Therefore, we have examined the total APA, chlorophyll a along with phosphatase producing bacteria (PPB) and related environmental parameters from nearshore to offshore in coastal waters off Trivandrum and Kochi regions differently affected by upwelling during the onset of monsoon. Off Trivandrum, APA in the offshore waters of 5-m layer at 2.23 μM P h- 1 was > 4 times higher than nearshore. Thus, low APA could be indicative of P sufficiency in coastal waters and higher activity suggestive of deficiency in offshore waters off Trivandrum. In contrast, there was less difference in APA between near and offshore surface waters off Kochi. Our results show that the regions differently affected by upwelling respond differently according to ambient P concentration, distance from shore or depth of water. These observations could apparently be applicable to other coastal systems as well, where gradients in upwelling and phosphate runoff have been noticed. Further studies on other transects would throw more light on the extent and direction of the relationship between APA and ambient P concentration. Such studies would help in understanding the level of control of this nutrient on the productivity of coastal waters.

  16. Spatial-temporal Variations of Alkaline Phosphatase Activity in the Kuilei Lake and Their Influencing Factors%傀儡湖水体中碱性磷酸酶活性的时空变化及其影响因素

    Institute of Scientific and Technical Information of China (English)

    张成艳; 成小英; 王建军; 张路; 杜应旸

    2013-01-01

    Alkaline phosphatase activity (APA) plays an important role in the biogeochemical cycling of phosphorus.The spatial-temporal distribution of APA and related environmental variables were studied in the Kuilei Lake.The research found significant seasonal and regional variations of APA in the water body,with lower APAs in outlet waters and higher in the estuarine.APAs were relatively low in winter (January),ranging from 2.06 to 17.33 nmol mL-1 h-1,and high in summer (July),ranging from 5.78 to 13.52 nmol mL-1 h-1.Correlation analyses indicated that APAs were significantly related to particulate organic nitrogen,total nitrogen and NO2--N.Other nitrogen forms (NO3--N and NH4+-N) were also related,though not significantly.The results implied that the factors related to nitrogen are the primary factors affecting APAs.%碱性磷酸酶在磷的生物地球化学循环过程中发挥着重要作用.以傀儡湖为研究区域,对其水体中碱性磷酸酶活性(Alkaline phosphatase activity,APA)及其理化性质的时空分布进行分析.结果表明,傀儡湖水体APA呈时空异质性:河道较低,河口则易出现较高的APA;全湖的APA存在较强的季节性变化,冬季(1月)最低,变化范围为2.06-17.33nmol mL-1h-1;夏季(7月)最高,变化范围为5.78-13.52 nmol mL-1 h-1.APA与环境因子相关性分析显示,APA与颗粒态有机氮浓度关系最为密切,与总氮含量的相关性其次,随后显著相关的因子为NO2--N,此外是NO3--N和NH4+-N.这一结果表明与氮元素有关的环境因子可能是影响APA的主要因素.

  17. Auricular Point Acupressure for Chronic Low Back Pain: A Feasibility Study for 1-Week Treatment

    Directory of Open Access Journals (Sweden)

    Chao-Hsing Yeh

    2012-01-01

    Full Text Available Objectives. The objective of this one-group, repeated-measures design was to explore the acceptance of auricular point acupressure (APA to reduce chronic low back pain (CLBP and estimate minimum clinically important differences (MCIDs for pain intensity change. Methods. Subjects received 7-day APA treatment. After appropriate acupoints were identified, vaccaria seeds were carefully taped onto each selected auricular point for 7-day. The Brief Pain Inventory Short Form (BPI was used to collect outcome data. Results. A total of 74 subjects participated in the study. Ten subjects dropped out and the retention rate was 87%. Subjects reported a 46% reduction in BPI worst pain, and over 50% reduction in BPI average pain, overall pain severity and pain interference by the end of study, and 62.5% subjects also reported less pain medication use. The MCIDs for the subscale of BPI ranged from .70 to 1.86 points. The percentage improvement of MCIDs from baseline was between 14.5–24.9%. Discussion. APA appears to be highly acceptable to patients with CLBP. A sham group is needed in order to differentiate the true effects of APA from the possible psychological effects of more frequent visits by the auricular therapist and patients’ expectation of the APA treatment.

  18. RNA regulatory elements and polyadenylation in plants

    Directory of Open Access Journals (Sweden)

    Arthur G. Hunt

    2012-01-01

    Full Text Available Alternative poly(A site choice (also known as alternative polyadenylation, or APA has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generation of transcripts with differing 3’-UTRs (and thus differing potential regulatory potential and of transcripts with differing protein-coding potential. Genome-wide studies of possible APA suggest a linkage with pre-mRNA splicing, and indicate a coincidence of and perhaps cooperation between RNA regulatory elements that affect splicing efficiency and the recognition of novel intronic poly(A sites. These studies also raise the possibility of the existence of a novel class of polyadenylation-related cis elements that are distinct from the well-characterized plant polyadenylation signal. Many potential APA events, however, have not been associated with identifiable cis elements. The present state of the field reveals a broad scope of APA, and also numerous opportunities for research into mechanisms that govern both choice and regulation of poly(A sites in plants.

  19. THE STUDY OF PRODUCTION AND MECHANISM OF ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH CORONARY HEART DISEASE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Objective To assess whether there was strong association between antiphospholipid antibodies(APA) and coronary heart disease(CHD), to study the environmental factors of APA production and APA pathogenic mechanism in patients with CHD.Methods Blood samples from 76 patients with CHD and 30 controls were tested for anticardiolipin antibodies IgG(ACA-IgG),human cytomegalovirus IgG,IgM(HCMV-IgG,IgM) by enzyme-link immunosorbant assay(ELISA) and 6-keto-PGF1a,endothelin(ET) by radioimmunoassay(RIA).Results A total of 27 patients(35.53%) were ACA positive in 76, as compared to 2 of 30(6.67%) healthy individuals, P<0.05. There was no difference in ACA among acute myocardial infarction(AMI,39.13%), old myocardial infarction(OMI,26.53%), unstable angina pectoris(UA,38.40%), P>0.05. The number of ACA positive subjects was higher in HCMV infection patients with CHD than no HCMV infectious patients with CHD. There was no PGI2 and ET level difference between ACA-IgG positive and negative CHD.Conclusion There are strong association between APA and CHD. The HCMV infection may be an environmental factor of APA production in CHD patients with raised ACA. The alteration of PGI2 and ET are not the pathogenic mechanism of ACA in patients with CHD.

  20. Intracranial hemorrhage and platelet transfusion after administration of anti-platelets agents: Fukushima Prefecture.

    Science.gov (United States)

    Suzuki, Yuhko; Sato, Taku; Sakuma, Jun; Ichikawa, Masahiro; Kishida, Yugo; Oda, Keiko; Watanabe, Yoichi; Goto, Takeshi; Sato, Masahiro; Nollet, Kenneth E; Saito, Kiyoshi; Ohto, Hitoshi

    2016-06-01

    We conducted a case series study to assess intracerebral hemorrhage (ICH) in the context of anti-platelets agents (APAs) and platelet (PLT) transfusion in Fukushima Prefecture.This study included patients who were newly diagnosed with ICH between January 2008 and June 2014 in the neurosurgical hospitals of Fukushima Prefecture. Four of ten neurosurgical hospitals responded to our questionnaire. Of 287 ICH patients, 51 (20.6%) were on APA therapy, of whom PLT transfusion was given to only one persistently bleeding patient who was on dual anti-platelet therapy. In a follow-up survey, 30 out of 51 ICH patients on APA therapy, average age 75 years, were analyzed, of whom 21 (70%) were male. The predominant underlying disease was diabetes mellitus. It is interesting to note that peripheral artery disease and aortic aneurysm were among the indications for APAs. ICH was mainly observed supratentorially. Hematoma enlargement was observed in 13 (44.8%) cases. By day 7, 3 patients (10%) had died from complications of ICH. In this study, we show that ICH during APA therapy matched what was observed in Kanagawa Prefecture. Whether or not a national survey differs, we anticipate greater statistical validity and an opportunity to improve patient outcomes in Japan and around the world. PMID:27210309

  1. Enhanced Soluble Serum CD40L and Serum P-Selectin Levels in Primary Aldosteronism.

    Science.gov (United States)

    Petramala, L; Iacobellis, G; Carnevale, R; Marinelli, C; Zinnamosca, L; Concistrè, A; Galassi, M; Iannucci, G; Lucia, P; Pignatelli, P; Ciardi, A; Violi, F; De Toma, G; Letizia, C

    2016-07-01

    Primary aldosteronism (PA) is one of the most frequent forms of secondary hypertension, associated with atherosclerosis and higher risk of cardiovascular events. Platelets play a key role in the atherosclerotic process. The aim of the study was to evaluate the platelet activation by measuring serum levels of soluble CD40L (sCD40L) and P-selectin (sP-selectin) in consecutive PA patients [subgroup: aldosterone-secreting adrenal adenoma (APA) and bilateral adrenal hyperplasia (IHA)], matched with essential hypertensive (EH) patients. The subgroup of APA patients was revaluated 6-months after unilateral adrenalectomy. In all PA group, we measured higher serum levels of both sP-selectin (14.29±9.33 pg/ml) and sCD40L (9.53±4.2 ng/ml) compared to EH patients (9.39±5.3 pg/ml and 3.54±0.94 ng/ml, respectively; pAPA, PA patients showed significant reduction of blood pressure (BP) values, plasma aldosterone (PAC) levels and ARR-ratio, associated with a significant reduction of sP-selectin (16.74±8.9 pg/ml vs. 8.1±3.8 pg/ml; pAPA patients (r=0.54; pAPA patients. PMID:27101095

  2. 澳大利亚预约定价安排(APA)制度借鉴

    Institute of Scientific and Technical Information of China (English)

    陈挺; 曾进

    2011-01-01

    Advance Pricing Arrangement (APA) system in Australia is comparatively mature, and Australia issued the latest guidance of APA Program on March 17th,2011. On the basis of introducing annual bulletin of APA and the latest guidance of APA in Australia, this paper classifies and summarizes eight items of Australian APA deserving for reference, and meanwhile makes an analysis on the developing orientation of APA system in China.%澳大利亚的预约定价安排(APA)制度比较成熟。2011年3月17日该国颁布了最新的预约定价安排指南。本文在介绍澳大利亚预约定价安排年度报告、最新预约定价安排指南的基础上,对澳大利亚预约定价安排制度中八项值得借鉴的内容作了梳理和归纳,同时,分析了我国预约定价安排制度的发展方向。

  3. CPSF30 at the Interface of Alternative Polyadenylation and Cellular Signaling in Plants.

    Science.gov (United States)

    Chakrabarti, Manohar; Hunt, Arthur G

    2015-01-01

    Post-transcriptional processing, involving cleavage of precursor messenger RNA (pre mRNA), and further incorporation of poly(A) tail to the 3' end is a key step in the expression of genetic information. Alternative polyadenylation (APA) serves as an important check point for the regulation of gene expression. Recent studies have shown widespread prevalence of APA in diverse systems. A considerable amount of research has been done in characterizing different subunits of so-called Cleavage and Polyadenylation Specificity Factor (CPSF). In plants, CPSF30, an ortholog of the 30 kD subunit of mammalian CPSF is a key polyadenylation factor. CPSF30 in the model plant Arabidopsis thaliana was reported to possess unique biochemical properties. It was also demonstrated that poly(A) site choice in a vast majority of genes in Arabidopsis are CPSF30 dependent, suggesting a pivotal role of this gene in APA and subsequent regulation of gene expression. There are also indications of this gene being involved in oxidative stress and defense responses and in cellular signaling, suggesting a role of CPSF30 in connecting physiological processes and APA. This review will summarize the biochemical features of CPSF30, its role in regulating APA, and possible links with cellular signaling and stress response modules. PMID:26061761

  4. CPSF30 at the Interface of Alternative Polyadenylation and Cellular Signaling in Plants

    Directory of Open Access Journals (Sweden)

    Manohar Chakrabarti

    2015-06-01

    Full Text Available Post-transcriptional processing, involving cleavage of precursor messenger RNA (pre mRNA, and further incorporation of poly(A tail to the 3' end is a key step in the expression of genetic information. Alternative polyadenylation (APA serves as an important check point for the regulation of gene expression. Recent studies have shown widespread prevalence of APA in diverse systems. A considerable amount of research has been done in characterizing different subunits of so-called Cleavage and Polyadenylation Specificity Factor (CPSF. In plants, CPSF30, an ortholog of the 30 kD subunit of mammalian CPSF is a key polyadenylation factor. CPSF30 in the model plant Arabidopsis thaliana was reported to possess unique biochemical properties. It was also demonstrated that poly(A site choice in a vast majority of genes in Arabidopsis are CPSF30 dependent, suggesting a pivotal role of this gene in APA and subsequent regulation of gene expression. There are also indications of this gene being involved in oxidative stress and defense responses and in cellular signaling, suggesting a role of CPSF30 in connecting physiological processes and APA. This review will summarize the biochemical features of CPSF30, its role in regulating APA, and possible links with cellular signaling and stress response modules.

  5. Probing attention prioritization during dual-task step initiation: a novel method.

    Science.gov (United States)

    Sun, Ruopeng; Shea, John B

    2016-04-01

    The present study investigated the attention allocation during reactive stepping using a continuous finger-tapping task. Ten healthy young subjects were recruited to participate in this study. Subjects were required to perform a rapid voluntary step with either left or right leg after hearing an auditory tone while tapping their right index finger on a handhold numeric keypad. Step initiation conditions included simple and choice reaction forward stepping with three variants of continuous tapping task that were: (1) single task-no concurrent finger-tapping task; (2) dual task easy-one-button tapping task; (3) dual task hard-four-button tapping task. Types of anticipatory postural adjustment (APA) were determined by the center of pressure trajectory. Reaction time, APA duration, and stepping latency were compared between APA types and various dual-task conditions. Wavelet analysis was performed on the stimulus-locked finger-tapping data to determine the frequency change of tapping speed related to reactive stepping. Results showed that postural performance was negatively affected only by the high-attention-demanding cognitive task. Significant reduction of finger-tapping speed post-stimulus presentation was observed across all test conditions, indicating attention shift during the execution of a step. In addition, the DTH condition induced early postural prioritization in choice reaction stepping when different motor programs needed to be planned and executed. Error APA also triggered larger deterioration of tapping performance compared to correct APA, indicating the perceived error and the remedial action require additional attentional resources. PMID:26708519

  6. Activating mutations in CTNNB1 in aldosterone producing adenomas.

    Science.gov (United States)

    Åkerström, Tobias; Maharjan, Rajani; Sven Willenberg, Holger; Cupisti, Kenko; Ip, Julian; Moser, Ana; Stålberg, Peter; Robinson, Bruce; Alexander Iwen, K; Dralle, Henning; Walz, Martin K; Lehnert, Hendrik; Sidhu, Stan; Gomez-Sanchez, Celso; Hellman, Per; Björklund, Peyman

    2016-01-01

    Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5-10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically correctable form of the disease. The WNT signaling pathway is activated in APAs. In other tumors, a frequent cause of aberrant WNT signaling is mutation in the CTNNB1 gene coding for β-catenin. Our objective was to screen for CTNNB1 mutations in a well-characterized cohort of 198 APAs. Somatic CTNNB1 mutations were detected in 5.1% of the tumors, occurring mutually exclusive from mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D. All of the observed mutations altered serine/threonine residues in the GSK3β binding domain in exon 3. The mutations were associated with stabilized β-catenin and increased AXIN2 expression, suggesting activation of WNT signaling. By CYP11B2 mRNA expression, CYP11B2 protein expression, and direct measurement of aldosterone in tumor tissue, we confirmed the ability for aldosterone production. This report provides compelling evidence that aberrant WNT signaling caused by mutations in CTNNB1 occur in APAs. This also suggests that other mechanisms that constitutively activate the WNT pathway may be important in APA formation. PMID:26815163

  7. Activating mutations in CTNNB1 in aldosterone producing adenomas

    Science.gov (United States)

    Åkerström, Tobias; Maharjan, Rajani; Sven Willenberg, Holger; Cupisti, Kenko; Ip, Julian; Moser, Ana; Stålberg, Peter; Robinson, Bruce; Alexander Iwen, K.; Dralle, Henning; Walz, Martin K.; Lehnert, Hendrik; Sidhu, Stan; Gomez-Sanchez, Celso; Hellman, Per; Björklund, Peyman

    2016-01-01

    Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5–10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically correctable form of the disease. The WNT signaling pathway is activated in APAs. In other tumors, a frequent cause of aberrant WNT signaling is mutation in the CTNNB1 gene coding for β-catenin. Our objective was to screen for CTNNB1 mutations in a well-characterized cohort of 198 APAs. Somatic CTNNB1 mutations were detected in 5.1% of the tumors, occurring mutually exclusive from mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D. All of the observed mutations altered serine/threonine residues in the GSK3β binding domain in exon 3. The mutations were associated with stabilized β-catenin and increased AXIN2 expression, suggesting activation of WNT signaling. By CYP11B2 mRNA expression, CYP11B2 protein expression, and direct measurement of aldosterone in tumor tissue, we confirmed the ability for aldosterone production. This report provides compelling evidence that aberrant WNT signaling caused by mutations in CTNNB1 occur in APAs. This also suggests that other mechanisms that constitutively activate the WNT pathway may be important in APA formation. PMID:26815163

  8. Evaluation of two statistical methods provides insights into the complex patterns of alternative polyadenylation site switching.

    Directory of Open Access Journals (Sweden)

    Jie Li

    Full Text Available Switching between different alternative polyadenylation (APA sites plays an important role in the fine tuning of gene expression. New technologies for the execution of 3'-end enriched RNA-seq allow genome-wide detection of the genes that exhibit significant APA site switching between different samples. Here, we show that the independence test gives better results than the linear trend test in detecting APA site-switching events. Further examination suggests that the discrepancy between these two statistical methods arises from complex APA site-switching events that cannot be represented by a simple change of average 3'-UTR length. In theory, the linear trend test is only effective in detecting these simple changes. We classify the switching events into four switching patterns: two simple patterns (3'-UTR shortening and lengthening and two complex patterns. By comparing the results of the two statistical methods, we show that complex patterns account for 1/4 of all observed switching events that happen between normal and cancerous human breast cell lines. Because simple and complex switching patterns may convey different biological meanings, they merit separate study. We therefore propose to combine both the independence test and the linear trend test in practice. First, the independence test should be used to detect APA site switching; second, the linear trend test should be invoked to identify simple switching events; and third, those complex switching events that pass independence testing but fail linear trend testing can be identified.

  9. High frequencies of elevated alkaline phosphatase activity and rickets exist in extremely low birth weight infants despite current nutritional support

    Directory of Open Access Journals (Sweden)

    Parker Bruce R

    2009-07-01

    Full Text Available Abstract Background Osteopenia and rickets are common among extremely low birth weight infants (ELBW, Methods We evaluated all ELBW infants admitted to Texas Children's Hospital NICU in 2006 and 2007. Of 211 admissions, we excluded 98 patients who were admitted at >30 days of age or did not survive/stay for >6 weeks. Bone radiographs obtained in 32 infants were reviewed by a radiologist masked to laboratory values. Results In this cohort of 113 infants, P-APA was found to have a significant inverse relationship with BW, gestational age and serum phosphorus. In paired comparisons, P-APA of infants Conclusion Elevation of P-APA >600 IU/L was very common in ELBW infants. BW was significantly inversely related to both P-APA and radiologic rickets. No single value of P-APA was related to radiological findings of rickets. Given the very high risk of osteopenia and rickets among ELBW infants, we recommend consideration of early screening and early mineral supplementation, especially among infants

  10. Uranium dust concentration measured in a conversion plant by aerosol sampling and application for dose calculation

    International Nuclear Information System (INIS)

    COMURHEX is a plant for converting mining concentrates into UF4. The atmosphere in different facilities is monitored daily using aerosol sampling devices (APA) placed in selected locations depending upon the workstations used by the operators. The results, entered every day into a computer program, can be displayed on individual diagrams for each shop. This program allows urinary uranium analyses over a given threshold to be targeted in addition to the systematic analysis performed periodically. In 1996, 23 urinary analyses corresponding to six events exceeding APA guide values were investigated. A direct approximation of systematic contamination from measurement data has recently been described using a deconvolution of individual monitoring results. Uptakes calculated from urine analysis using this method are correlated with the increase of the APA values. This method implies that a specific monitoring protocol is developed by setting up a minimum number of urinary analyses in one year, a maximum interval between two examinations, considering the chemical composition of the components and the urinary level measurements. Internal dosimetry based only on APA values is not sufficient for operational medical monitoring. To reduce the uncertainties in dose calculation, a special program based on bioassay analysis initiated by the APA guide values is better adapted to estimating the internal dose to each worker in the different facilities of the plant. (author)

  11. Development of NASA's Accident Precursor Analysis Process Through Application on the Space Shuttle Orbiter

    Science.gov (United States)

    Maggio, Gaspare; Groen, Frank; Hamlin, Teri; Youngblood, Robert

    2010-01-01

    Accident Precursor Analysis (APA) serves as the bridge between existing risk modeling activities, which are often based on historical or generic failure statistics, and system anomalies, which provide crucial information about the failure mechanisms that are actually operative in the system. APA docs more than simply track experience: it systematically evaluates experience, looking for under-appreciated risks that may warrant changes to design or operational practice. This paper presents the pilot application of the NASA APA process to Space Shuttle Orbiter systems. In this effort, the working sessions conducted at Johnson Space Center (JSC) piloted the APA process developed by Information Systems Laboratories (ISL) over the last two years under the auspices of NASA's Office of Safety & Mission Assurance, with the assistance of the Safety & Mission Assurance (S&MA) Shuttle & Exploration Analysis Branch. This process is built around facilitated working sessions involving diverse system experts. One important aspect of this particular APA process is its focus on understanding the physical mechanism responsible for an operational anomaly, followed by evaluation of the risk significance of the observed anomaly as well as consideration of generalizations of the underlying mechanism to other contexts. Model completeness will probably always be an issue, but this process tries to leverage operating experience to the extent possible in order to address completeness issues before a catastrophe occurs.

  12. A priori analysis: an application to the estimate of the uncertainty in course grades

    CERN Document Server

    Lippi, G L

    2014-01-01

    The a priori analysis (APA) is discussed as a tool to assess the reliability of grades in standard curricular courses. This unusual, but striking application is presented when teaching the section on data treatment of a Laboratory Course to illustrate the characteristics of the APA and its potential for widespread use, beyond the traditional Physics Curriculum. The conditions necessary for this kind of analysis are discussed, the general framework is set out and a specific example is given to illustrate its various aspects. Students are often struck by this unusual application and are more apt to remember the APA. Instructors may also benefit from some of the gathered information, as discussed in the paper.

  13. The Angstrom Project Alert System: real-time detection of extragalactic microlensing

    CERN Document Server

    Darnley, M J; Newsam, A; Duke, J P; Gould, A; Han, C; Ibrahimov, M A; Im, M; Jeon, Y B; Karimov, R G; Lee, C U; Park, B G

    2006-01-01

    The Angstrom Project is undertaking an optical survey of stellar microlensing events across the bulge region of the Andromeda Galaxy (M31) using a distributed network of two-meter class telescopes. The Angstrom Project Alert System (APAS) has been developed to identify in real time candidate microlensing and transient events using data from the Liverpool and Faulkes North robotic telescopes. This is the first time that real-time microlensing discovery has been attempted outside of the Milky Way and its satellite galaxies. The APAS is designed to enable follow-up studies of M31 microlensing systems, including searches for gas giant planets in M31. Here we describe the APAS and we present a few example light curves obtained during its commissioning phase which clearly demonstrate its real-time capability to identify microlensing candidates as well as other transient sources.

  14. Fabrication and optical property of metal nanowire arrays embedded in anodic porous alumina membrane

    Science.gov (United States)

    Takase, Kouichi; Shimizu, Tomohiro; Sugawa, Kosuke; Aono, Takashige; Shirai, Yuma; Nishida, Tomohiko; Shingubara, Shoso

    2016-06-01

    Nanowires embedded in nanopores are potentially tough against surface scraping and agglomeration. In this study, we have fabricated Au and Ni nanowires embedded into anodic porous alumina (APA) and investigated their reflectance to study the effects of surface plasmon absorption properties and conversion from solar energy to thermal energy. Au nanowires embedded into APA show typical gold surface plasmon absorption at approximately 530 nm. On the other hand, Ni nanowires show quite a low reflectance under 600 nm. In the temperature elevation test, both Au and Ni nanowire samples present the same capability to warm up water. It means that Ni nanowires embedded into APA have almost the same photothermal activity as Au nanowires.

  15. Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation.

    Science.gov (United States)

    Hardy, Jessica G; Norbury, Chris J

    2016-08-15

    Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA. PMID:27528751

  16. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

    DEFF Research Database (Denmark)

    Beuschlein, Felix; Boulkroun, Sheerazed; Osswald, Andrea;

    2013-01-01

    Primary aldosteronism is the most prevalent form of secondary hypertension. To explore molecular mechanisms of autonomous aldosterone secretion, we performed exome sequencing of aldosterone-producing adenomas (APAs). We identified somatic hotspot mutations in the ATP1A1 (encoding an Na+/K+ ATPase α...... subunit) and ATP2B3 (encoding a Ca2+ ATPase) genes in three and two of the nine APAs, respectively. These ATPases are expressed in adrenal cells and control sodium, potassium and calcium ion homeostasis. Functional in vitro studies of ATP1A1 mutants showed loss of pump activity and strongly reduced...... affinity for potassium. Electrophysiological ex vivo studies on primary adrenal adenoma cells provided further evidence for inappropriate depolarization of cells with ATPase alterations. In a collection of 308 APAs, we found 16 (5.2%) somatic mutations in ATP1A1 and 5 (1.6%) in ATP2B3. Mutation...

  17. 微囊化人血管抑素基因工程细胞对人脐静脉内皮细胞增殖的影响%Effect of Microencapsulated Human Angiostatin Gene Engineered Cell on the Proliferation of Human Umbilical Vein Endothelial Cell

    Institute of Scientific and Technical Information of China (English)

    罗芸; 薛毅珑; 赵卉

    2012-01-01

    Objective To study the effect of microencapsulated human angiostatin gene engineered cell on the proliferation of human umbilical vein endothelial cell Huecv304. Methods Alginate - polylysine -alginate (APA)was used to encapsulate 293 cells expressing human angioslain (APA - hAS/293) or empty vector (APA -0/293). Microencapsulated APA - hAS/293 or APA -0/293 cells were co - cultured with Huecv304 in different cell concentration. After 0, 24, 48 and 72h, the proliferation of Huecv304 was measured with MTT assay. Results Microencapsulated APA - hAS/293 inhibited the proliferation of cocultured Huecv304 cells ( P < 0. 01 ) in a dose -dependent manner. While microencapsulated APA - 0/293 didn't inhibit the proliferation of Huecv304 cells in co - culture. Conclusion The secretion of gene engineered cells expressing human angiostatin could pass through the membrane of microencapsule and inhibit the proliferation of human umbilical vein endothelial cells.%目的 了解海藻酸钠-多聚赖氨酸-海藻酸钠(alginate - polylysine - alginate,APA)微囊化人血管抑素基因工程细胞对人脐静脉内皮细胞(Huecv304)增殖的影响.方法 采用APA制备微囊包裹的表达人血管抑素(human angiostatin,hAS)的基因工程细胞(APA - hAS/293细胞微囊)或空载体转染的基因工程细胞(APA - 0/293细胞微囊).分别将上述两种细胞微囊以不同浓度与人脐静脉内皮细胞Huecv304细胞共培养,于培养0、24、48及72h时,以MTT法测定Huecv304细胞的增殖情况.结果 APA - hAS/293细胞微囊对共培养的Huecv304细胞的增殖具有明显的抑制作用(P<0.01),且具有良好的量效关系.而对照组APA - 0/293细胞微囊对Huecv304细胞的增殖无明显抑制作用.结论 体外培养的表达人血管抑素基因的工程细胞的分泌物可以通过微囊膜并对人脐静脉内皮细胞的增殖产生显著的抑制效应.

  18. Environmental Audit of the Alaska Power Administration

    International Nuclear Information System (INIS)

    This report documents the results of the Comprehensive Baseline Environmental Audit of the Alaska Power Administration (APA) headquartered in Juneau, Alaska. This Audit was conducted by the US Department of Energy's (DOE's) Office of Environmental Audit (EH-24) from August 24 to December 8, 1992. The scope of the Audit was comprehensive, covering all environmental programs and activities with the exception of those relating to the National Environmental Policy Act (NEPA). Specifically considered was the compliance status of APA regarding Federal, state, and local statutes and regulations, DOE Orders and Directives, and best management practices. The technical disciplines addressed by the Audit were: air, surface water/drinking water, groundwater, waste management, toxic and chemical materials, quality assurance, inactive waste sites, and environmental management. Due to the nature of the activities carried out at the two Federal hydroelectric projects operated by APA, the area of radiation was not investigated during the Audit

  19. 预约定价安排在防止和解决转让定价争议中的作用

    Institute of Scientific and Technical Information of China (English)

    池澄; 饶戈军

    2012-01-01

    This paper introduces the evolution, development and prospect of Advancing Pricing Arrangement (APA) worldwide, and analyzes difficulties in the APA application as well as the status of APA development in China, and finally puts forward relevant suggestions on how tax authorities shall conduct tax administration concerning APA.%本文介绍了预约定价安排在全球的历史沿革、发展与展望,分析了预约定价安排在实际开展中的难点及在中国的开展情况,并提出了中国税务机关预约定价安排税收管理方面的相关建议。

  20. A priori analysis: an application to the estimate of the uncertainty in course grades

    International Nuclear Information System (INIS)

    A priori analysis (APA) is discussed as a tool to assess the reliability of grades in standard curricular courses. This unusual, but striking, application is presented when teaching the section on the data treatment of a laboratory course to illustrate the characteristics of the APA and its potential for widespread use, beyond the traditional physics curriculum. The conditions necessary for this kind of analysis are discussed, the general framework is set out and a specific example is given to illustrate its various aspects. Students are often struck by this unusual application and are more apt to remember the APA. Instructors may also benefit from some of the gathered information, as discussed in the paper. (paper)

  1. Faculty role modeling of professional writing: one baccalaureate nursing program's experience.

    Science.gov (United States)

    Newton, Sarah E

    2008-01-01

    According to The Essentials of Baccalaureate Education for Professional Nursing Practice (American Association of Colleges of Nursing, 1998), professional writing is an important outcome of baccalaureate nursing education. Most baccalaureate nursing programs in the United States expect formally written student papers to adhere to the style requirements outlined in the Publication Manual of the American Psychological Association (APA, 2001). It is essential for the baccalaureate nursing faculty members who evaluate student papers to be role models for the desired writing behaviors to facilitate student attainment of professional writing outcomes. However, to what extent nursing faculty members' writing behaviors and knowledge of the APA style requirements impact student writing outcomes is not known because the issue has not been addressed in the literature. The purpose of this article is to describe one Midwestern baccalaureate nursing program's faculty development efforts to assess faculty familiarity with the APA style requirements and how such knowledge may impact baccalaureate nursing students' writing outcomes. PMID:18358441

  2. Best kept secrets ... First Coast Systems, Inc. (FCS).

    Science.gov (United States)

    Andrew, W F

    1991-04-01

    The FCS/APaCS system is a viable option for small-to medium-size hospitals (up to 400 beds). The table-driven system takes full advantage of IBM AS/400 computer architecture. A comprehensive application set, provided in an integrated database environment, is adaptable to multi-facility environments. Price/performance appears to be competitive. Commitment to IBM AS/400 environment assures cost-effective hardware platforms backed by IBM support and resources. As an IBM Health Industry Business Partner, FCS (and its clients) benefits from IBM's well-known commitment to quality and service. Corporate emphasis on user involvement and satisfaction, along with a commitment to quality and service for the APaCS systems, assures clients of "leading edge" capabilities in this evolutionary healthcare delivery environment. FCS/APaCS will be a strong contender in selected marketing environments. PMID:10120779

  3. Ethical Considerations for Psychologists Taking a Public Stance on Controversial Issues: The Balance Between Personal and Professional Life.

    Science.gov (United States)

    Haeny, Angela M

    2014-07-01

    Previous literature has documented the general issues psychologists often face while balancing their personal and professional lives. The struggle stems from attempting to satisfy the need to maintain a life outside of work while having the professional obligation to follow the American Psychological Association's (APA's) Ethical Principles of Psychologists and Code of Conduct (Ethics Code) to prevent their personal lives from interfering with their professional roles and relationships. The present paper analyzes the subject of psychologists taking a public position on controversial public issues. Although the APA Ethics Code does not restrict how psychologists conduct themselves during their personal time, taking a public stance on a controversial issue could potentially strain professional relationships and inadvertently reflect negatively on the profession. The present paper examines ethical issues that a) should be taken into account before psychologists take a public position on a controversial issue, and b) are in conflict with APA's Ethics Code or current research. PMID:25342876

  4. Correlation of Traditional Point a With Anatomic Location of Uterine Artery and Ureter in Cancer of the Uterine Cervix

    International Nuclear Information System (INIS)

    Purpose: Point A, used for dose specification for intracavitary brachytherapy for cervical cancer, is the point at which the uterine artery and ureter cross. This study assessed compatibility of commonly used traditional point A (TPA) and actual anatomic point A (APA). Methods and Materials: We visualized and placed radiopaque clips at the APA during pelvic and paraaortic lymphadenectomy in 11 patients with cervical carcinoma. Orthogonal and oblique radiographs were obtained after insertion of brachytherapy applicators. We measured the distance between the TPA and APA and estimated the brachytherapy dose to each of the two points. Results: A total of 64 brachytherapy treatments were performed. The mean distances between the TPA and APA were 5.2 ± 1.0 cm on the right and 5.4 ± 1.1 cm on the left. The estimated brachytherapy doses delivered to the APA as a percentage of the presumed 500-cGy fraction size to the TPA were 35.2% (176.6 ± 59.0 cGy) on the right and 30.0% (150.2 ± 42.9 cGy) on the left. The marked discrepancy in the position of the two points was not related to individual kinetic variations during brachytherapy treatment, tumor size, or bladder filling. Conclusions: The conventional TPA does not provide an accurate estimate of the APA determined during lymphadenectomy, indicating a need to reevaluate the current practice for determining the brachytherapy prescription for cervical cancer. ( (ClinicalTrials.gov) Identifier, NCT00319462)

  5. Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis.

    Science.gov (United States)

    Lehrer, Douglas S; Pato, Michele T; Nahhas, Ramzi W; Miller, Brian R; Malaspina, Dolores; Buckley, Peter F; Sobell, Janet L; Walsh-Messinger, Julie; Cohort Consortium, Genomic Psychiatry; Pato, Carlos N

    2016-06-01

    Advanced paternal age (APA) is a risk factor for schizophrenia (Sz) and bipolar disorder (BP). Putative mechanisms include heritable genetic factors, de novo mutations, and epigenetic mechanisms. Few studies have explored phenotypic features associated with APA. The Genomic Psychiatry Cohort established a clinically characterized repository of genomic samples from subjects with a Sz-BP diagnosis or unaffected controls, 12,975 with parental age information. We estimated relative risk ratios for Sz, schizoaffective depressed and bipolar types (SA-D, SA-B), and BP with and without history of psychotic features (PF) relative to the control group, comparing each paternal age group to the reference group 20-24 years. All tests were two-sided with adjustment for multiple comparisons. Subjects with fathers age 45+ had significantly higher risk for all diagnoses except for BP w/o PF. APA also bore no significant relation to family psychiatric history. In conclusion, we replicated APA as a risk factor for Sz. To our knowledge, this is the first published report of APA in a BP sample stratified by psychosis history, extending this association only in BP w/PF. This suggests that phenotypic expression of the APA effect in Sz-BP spectrum is psychosis, per se, rather than other aspects of these complex disorders. The lack of a significant relationship between paternal age and familial disease patterns suggests that underlying mechanisms of the paternal age effect may involve a complex interaction of heritable and non-heritable factors. The authors discuss implications and testable hypotheses, starting with a focus on genetic mechanisms and endophenotypic expressions of dopaminergic function. © 2015 Wiley Periodicals, Inc. PMID:26183902

  6. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

    OpenAIRE

    Scholl, Ute I; Goh, Gerald; Stölting, Gabriel; de Oliveira, Regina Campos; Choi, Murim; Overton, John D; Fonseca, Annabelle L.; Korah, Reju; Lee F. Starker; Kunstman, John W.; Prasad, Manju L.; Hartung, Erum A.; Mauras, Nelly; Benson, Matthew R.; Brady, Tammy

    2013-01-01

    Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining hormone aldosterone and are a common cause of severe hypertension. Recurrent mutations in the potassium channel KCNJ5 that result in cell depolarization and Ca2+ influx cause ~40% of these tumors 1 . We found five somatic mutations (four altering glycine 403, one altering isoleucine 770) in CACNA1D, encoding a voltage-gated calcium channel, among 43 non-KCNJ5-mutant APAs. These mutations lie in S6 segments...

  7. Purification and Characterization of Abrus precatorius Agglutinin

    OpenAIRE

    Absar, Nural; Funatsu, Gunki

    1984-01-01

    Abrus pvecatorius agglutinin (APA) has been purified by a new purification procedure from the seeds of semen jequiriti produced in Bangladesh and Taiwan. The method was accomplished by 33-50% saturation ammonium sulfate fraction from 1% acetic acid extract of the seeds of semen jequiriti using gel filtration on Sephadex G-75 followed by DEAE-cellulose column chromatography. The molecular weight was estimated to be 126,000 and 122,000 by gel filtration on Sephadex G-150 for Bangladesh-APA and ...

  8. 抗磷脂抗体综合征的研究进展

    Institute of Scientific and Technical Information of China (English)

    赫晓燕; 牛艺儒; 谢建山

    2007-01-01

    抗磷脂抗体(APA)与APA综合征的发生密切相关,但APA引起APA综合征的发病机制仍不清楚,近年来APA通过抑制蛋白C(PC)途径,引起获得抗活化蛋白C现象进而导致血栓的研究受到关注.本文结合抗磷脂抗体(antiphospholipid antibody,APA)的最新研究进展,从病理角度综述APA综合征及其治疗和发展前景.

  9. Præsentationsformater for bibliografier, publikationslister og andre referencer

    DEFF Research Database (Denmark)

    Wille, Niels Erik

    Vejledning i udformning af teksthenvisninger og referencelister, med et udvalg af eksempler fra de mest udbredte "systemer": F.eks. Dansk Standard, Modern Language Aasociation (MLA), American Psychological Association (APA), Modern Humanities Research Association (MHRA), Chicago Manual of Style...... gennemarbejdet system, men en art kælenavn for en form for teksthenvisninger som forekommer i flere forskellige systemer, bl.a. APA, CMS2, CSE/CBE m.fl. Vejledningen er knyttet til kurset Ret&Rigtigt som udbydes af fagene Kommunikation og Performance-design i samarbejde....

  10. Enzyme assays for synthesis and degradation of 2-5As and other 2'-5' oligonucleotides

    DEFF Research Database (Denmark)

    Poulsen, Jesper Buchhave; Kjær, Karina Hansen; Justesen, Just;

    2015-01-01

    demonstration of enzyme assays measuring synthetase and nuclease activities, respectively. The synthetase assays produce only a single reaction product allowing for very precise kinetic assessment of the enzymes. We present an assay using dATP and the A(pA)3 tetramer core as substrates, which requires prior...... isolation of A(pA)3. A synthetase assay using either of the dNTPs individually together with NAD(+) as substrates is also presented. The nuclease reactions make use of the isolated 2'-5' oligoadenylates in producing a mixture of shorter reaction products, which are resolved by ion-exchange chromatography to...

  11. Impaired motor preparation and execution during standing reach in people with chronic stroke.

    Science.gov (United States)

    McCombe Waller, Sandy; Yang, Chieh-Ling; Magder, Laurence; Yungher, Don; Gray, Vicki; Rogers, Mark W

    2016-09-01

    Movement preparation of both anticipatory postural adjustments (APAs) and goal directed movement during a standing reaching task in adults with chronic hemiparesis and healthy controls was investigated. Using a simple reaction time paradigm, while standing on two separate force platforms, subjects received a warning light cue to "get ready to reach" followed 2.5s later by an imperative light cue to "reach as quickly as possible" with the paretic arm (matched arm for controls) to touch a target in front of them for a total of 90 trials. In 30 of the reaching trials a loud acoustic stimulus (LAS) of 123 dB was randomly - -200, or 0ms relative to the "go" cue. APA (postural) responses were characterized by the onset and maximal posterior displacement of center of pressure (CoP) and onset/offset of electromyography (EMG) from tibialis anterior (TA), soleus (SOL), while reach was characterized by onset and maximal forward displacement of the reach hand and onset of the anterior (AD), biceps brachii (BB) and middle deltoid (MD). Subjects with stroke, demonstrated a marked reduction in the occurrence of the StartReact responses for both APA and forward reach at all LAS time points indicating movement preparation dysfunction. Movement execution during a cued reach showed significant delays in APA and reach onsets, significant reduction in the magnitude of APA (posterior CoP displacement) and reach excursion, and an increased latency between the APA and reach compared to controls. EMG activation patterns for the TA and SOL demonstrated co contraction compared to the temporally sequenced pattern of control subjects. When LAS was provided at the "go" there were earlier but not significant differences in APA onset latency compared to reaching without LAS and significant delays in reach onset latency when compared to control subjects with or without LAS. An early burst of EMG in biceps brachii muscles with a further delay of the reach onset compared to reaching without LAS may

  12. Investigation of a possible outbreak of carbapenem-resistant Acinetobacter baumannii in Odense, Denmark using PFGE, MLST and whole-genome-based SNPs

    DEFF Research Database (Denmark)

    Hammerum, Anette M; Hansen, Frank; Skov, Marianne N;

    2015-01-01

    carbapenem-resistant A. baumannii were detected at Odense University Hospital, Odense, Denmark. These isolates were typed by PFGE, with ApaI and SmaI, respectively, and subjected to WGS. The WGS data were used for in silico extraction of MLST types using two different schemes, resistance genes and SNPs, to...... which 31 publicly available A. baumannii genomes were added. RESULTS: Using ApaI, the eight isolates had four different PFGE profiles, which were further differentiated using SmaI, separating one of the profiles into two distinct PFGE types. Five ST2 (Pasteur MLST) OXA-23-producing isolates, two ST1 OXA...

  13. Steered Molecular Dynamics Simulation on the Binding of NNRTI to HIV-1 RT

    Energy Technology Data Exchange (ETDEWEB)

    Shen, Lingling; Shen, Jianhua; Luo, Xiaomin; Cheng, Feng; Xu, Yechun; Chen, Kaixian; Arnold, Edward; Ding, Jianping; Jiang, Hualiang

    2003-06-01

    HIV-1 reverse transcriptase (RT) is the primary target for anti-AIDS chemotherapy. Nonnucleoside RT inhibitors (NNRTIs) are very potent and most promising anti-AIDS drugs that specifically inhibit HIV-1 RT. The binding and unbinding processes of alpha-APA, an NNRTI, have been studied using nanosecond conventional molecular dynamics and steered molecular dynamics simulations. The simulation results show that the unbinding process of alpha-APA consists of three phases based on the position of alpha-APA in relation to the entrance of the binding pocket. When alpha-APA is bound in the binding pocket, the hydrophobic interactions between HIV-1 RT and alpha-APA dominate the binding; however, the hydrophilic interactions (both direct and water-bridged hydrogen bonds) also contribute to the stabilizing forces. Whereas Tyr-181 makes significant hydrophobic interactions with alpha-APA, Tyr-188 forms a strong hydrogen bond with the acylamino group (N14) of alpha-APA. These two residues have very flexible side chains and appear to act as two ''flexible clamps'' discouraging alpha-APA to dissociate from the binding pocket. At the pocket entrance, two relatively inflexible residues, Val-179 and Leu-100, gauge the openness of the entrance and form the bottleneck of the inhibitor-unbinding pathway. Two special water molecules at the pocket entrance appear to play important roles in inhibitor recognition of binding and unbinding. These water molecules form water bridges between the polar groups of the inhibitor and the residues around the entrance, and between the polar groups of the inhibitor themselves. The water-bridged interactions not only induce the inhibitor to adopt an energetically favorable conformation so the inhibitor can pass through the pocket entrance, but also stabilize the binding of the inhibitor in the pocket to prevent the inhibitor's dissociation. The complementary steered molecular dynamics and conventional molecular dynamics

  14. Norine G. Johnson (1935-2011).

    Science.gov (United States)

    Cantor, Dorothy W; Goodheart, Carol D

    2012-04-01

    On November 19, 2011, Norine G. Johnson, the ninth woman to serve as president of the American Psychological Association (APA), lost a valiant battle with cancer. Norine's curiosity about her grandmother's strength led to much of her later work on the development of strength and resiliency in adolescent girls and in women. She received her doctorate in 1972, with a minor in child development, and she became one of the first to be considered a pediatric psychologist, a newly emerging specialty. Norine became involved in organized psychology as her children got older. When she learned there had not been a woman president of the Massachusetts Psychological Association (MPA) for almost 50 years, she was appalled. An ardent feminist, who had served on MPA's Board of Directors, she could not let the situation remain that way. She ran for president and won, serving from 1981 to 1983, and then mentored many women colleagues into the role. MPA sent her to the Council of the APA as one of their representatives, and she immediately ran for a seat on the Finance Committee, later serving as chair of the committee. During her tenure on the Finance Committee, she helped create financial policy that changed APA from an organization whose assets were threatened and shrinking to a financially solid association. Norine considered Division 35 (Psychology of Women) to be her home in APA, a place filled with warmth, collegiality, and shared values. She and Judith Worell spearheaded the extremely important and successful 1993 National Conference on Education and Training in Feminist Practice. Norine was elected to the APA Board of Directors in 1997, where she served with distinction, continuing to focus on the financial well-being of the Association. Not surprisingly, she went from that role to being elected APA president. Her focus as president was on the changes in the health care delivery system in the United States. She was a staunch champion of the biopsychosocial model of health

  15. Advanced Pricing Arrangements : Development of the Swedish legislation

    OpenAIRE

    Wedin, Axel

    2012-01-01

    In recent years transfer pricing has become one of the most important issues for tax authorities and companies. As the area has become more complex this has lead to an increase in disputes and a need for dispute resolution procedure. Advanced Pricing Arrangement (APA) is the latest dispute resolution procedure and was introduced in Sweden in 2010. APAs determine a taxpayer’s future taxation of cross-border transaction by a taxpayer. Through co-operation the taxpayer and the tax authorities re...

  16. Sizing of the Haemophilus influenzae Rd genome by pulsed-field agarose gel electrophoresis.

    OpenAIRE

    Lee, J J; Smith, H O

    1988-01-01

    The four restriction enzymes ApaI (5'-GGGCCC), EagI (5'-CGGCCG), NaeI (5'-GCCGGC), and SmaI (5'-CCCGGG) were found to produce distributions of DNA fragment sizes useful for mapping of the Haemophilus influenzae Rd genome by pulsed-field agarose gel electrophoresis. ApaI produced 21 fragments (range, 1.6 to 305 kilobases [kb]), EagI yielded 30 fragments (0.6 to 339 kb), NaeI produced 32 fragments (2.3 to 290 kb), and SmaI yielded 16 fragments (6.0 to 377 kb). Summation of the fragment lengths ...

  17. The role of animated pedagogical agents in scenario-based language e-learning: a case-study

    OpenAIRE

    Reategui, Eliseo; Polonia, Eunice; Roland, Letícia

    2007-01-01

    Scenario-based language e-learning (SBeL) is focused on contextual learning, since it uses authentic activities that can improve communication skills. This paper reports a case-study that proposes the use of animated pedagogical agents (APAs) in a Brazilian Portuguese web-based course built under a mix of task- and scenario-based approaches. Its main purpose is to discuss how APAs can be used to improve students' communicative skills, cultural awareness and level of interaction with course's ...

  18. Synthesis and properties of defined DNA oligomers containing base mispairs involving 2-aminopurine.

    OpenAIRE

    Eritja, R.; Kaplan, B E; Mhaskar, D; Sowers, L C; Petruska, J; Goodman, M F

    1986-01-01

    DNA heptamers containing the mutagenic base analogue 2-aminopurine (AP) have been chemically synthesized and physically characterized. We report on the relative stabilities of base pairs between AP and each of the common DNA bases, as determined from heptamer duplex melts at 275 and 330 nm. Base pairs are ranked in order of decreasing stability: AP.T greater than AP.A greater than AP.C greater than AP.G. It is of interest that AP.A is more stable than AP.C even though DNA polymerase strongly ...

  19. Structures and related properties of helical, disulfide-stabilized peptides

    Energy Technology Data Exchange (ETDEWEB)

    Pagel, M.D. [Univ. of California, Berkeley, CA (United States). Dept. of Chemistry]|[Lawrence Berkeley Lab., CA (United States)

    1993-11-01

    The three dimensional structure of several peptides were determined by NMR spectroscopy and distance geometry calculations. Each peptide formed a predictable, rigid structure, consisting of an {alpha}-helix, a {open_quotes}scaffold{close_quotes} region which packed along one face of the helix, and two disulfide bridges which covalently connect the helix and scaffold regions. The peptide Apa-M5 was designed to constrain the M5 peptide from MLCK in a helical geometry using the apamin disulfide scaffold. This scaffold constrains the N- terminal end of the helix with two disulfide bridges and a reverse turn. Like the M5 peptide, Apa-M5 was found to bind calmodulin in a Ca{sup 2+}-dependent 1:1 stoichiometry. However, the dissociation constant of the (Apa-M5)-calmodulin complex, 107 nM, was 100-fold higher than the dissociation constant of the M5-calmodulin complex. This difference was due to a putative steric overlap between the Apa-M5 scaffold and calmodulin. The peptide Apa-Cro was designed to replace the large structural protein matrix of {lambda} Cro with the apamin disulfide scaffold. However, Apa-Cro did not bind the consensus DNA operator half-site of {lambda} Cro, probably due to a steric overlap between the Apa-Cro disulfide framework and the DNA. The amino acid sequence of the scaffold-disulfide bridge arrangement of the peptide Max was derived from the core sequence of scyllatoxin, which contains an {alpha}-helix constrained at the C-terminal end by two disulfide bridges and a two-stranded {beta}sheet scaffold. Max was shown to fold with >84% yield to form a predictable, stable structure that is similar to scyllatoxin. The folding and stability properties of Max make this scaffold and disulfide bridge arrangement an ideal candidate for the development of hybrid sequence peptides. The dynamics of a fraying C-terminal end of the helix of the peptide Apa-AlaN was determined by analysis of {sup 15}N NMR relaxation properties.

  20. Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum.

    OpenAIRE

    E. Alvarez; Cantoral, J M; Barredo, J L; Díez, B; Martín, J F

    1987-01-01

    The acyl coenzyme A (CoA):6-aminopenicillanic acid (6-APA) acyltransferase of Penicillium chrysogenum AS-P-78 was purified to homogeneity, as concluded by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing. The enzyme is a monomer with a molecular weight of 30,000 +/- 1,000 and a pI of about 5.5. The optimal pH and temperature were 8.0 and 25 degrees C, respectively. This enzyme converts 6-APA into penicillin by using phenylacetyl CoA or phenoxyacetyl CoA as ac...

  1. Estudos etnobotanicos em comunidades continentais da area de proteção ambiental de Guaraqueçaba Parana - Brasil

    OpenAIRE

    Lima, Roberto Xavier de

    2013-01-01

    Este trabalho tem por objetivo resgatar o conhecimento etnobotânico em dez comunidades continentais da Área de Proteção Ambiental (APA) de Guaraqueçaba. A APA está localizada no litoral norte do Estado do Paraná - Brasil, é uma Unidade de Conservação composta por ecossistemas da Floresta Ombrófila Densa (Floresta Atlântica) em bom estado de conservação, compreendendo 313.400 ha. Populações Tradicionais, com elevado conhecimento da flora regional, estão distribuídas em 57 localidades. Foram s...

  2. Transplantation of microencapsulated human retinal pigment epithelial cells in Parkinsonian rats%微囊化人视网膜色素上皮细胞移植治疗帕金森病的实验研究

    Institute of Scientific and Technical Information of China (English)

    李锐; 宗伟; 郭民侠; 蒋宏伟

    2009-01-01

    目的 观察微囊化人视网膜色素上皮(RPE)细胞移植治疗帕金森病(PD)大鼠的疗效. 方法 采用机械分离法和酶消化法原代培养人RPE细胞,传代后用高压静电微胶囊成型装置制作海藻酸钠-多聚赖氨酸-海藻酸钠微囊化细胞,将其立体定向移植人6-羟基多巴胺(6-OHDA)所致的PD模型大鼠的右侧纹状体.实验分为模型组、裸细胞(RPE)组、空囊对照(APA)组以及微囊化细胞(APA-RPE)组.检测各组大鼠移植前后阿朴吗啡诱导的旋转行为变化和移植后8周纹状体中多巴胺(DA)的含量. 结果 APA-RPE组大鼠在移植后4周阿朴吗啡诱发的旋转次数[(6.25±1.04)r/min]开始减少,与移植前[(12.88±7.34)r/min]相比减少幅度为51.48%,至第8周[(5.87±2.03)r/min]减少更加明显,减少幅度为54.43%,差异均有统计学意义(P<0.05);与模型组[(108.14±1.89)mol/L]比较,APA-RPE组移植后8周[(342.63±28.32)mol/L]大鼠纹状体DA含量明显增加,差异有统计学意义(P<0.05),而RPE组和APA组未见明显变化. 结论 微囊化人RPE细胞对PD大鼠模型有治疗作用,可作为一种前景良好的治疗PD的方法 进一步研究.%Objective To observe the therapeutic effect of microencapsulated human retinal pigment epithelial (RPE) cell transplantation into the striatum in a rat model of Parkinson' disease (PD). Methods Cultured RPE cells were microencapsulated by alginate-polylysine-alginate (APA) using a high voltage electrostatic system. The Parkinsonian rats were divided into 4 groups, namely the model group, RPE group, APA group and RPE-APA group, and in the latter 3 groups, RPE cells, empty APA microcapsules and APA-capsulated RPE cells, respectively, were transplanted into the right striatum of the rats via stereotactic surgery. After the transplantation, the changes in apomorphine-induced rotation of the rats were investigated and the striatum DA contents were measured with high-performance liquid chromatography with

  3. Dimensional approaches to psychiatric classification: refining the research agenda for DSM-V: an introduction.

    Science.gov (United States)

    Regier, Darrel A

    2007-01-01

    The American Psychiatric Association (APA) will publish the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V), in 2012. This paper reviews the extended, multi-faceted research planning preparations that APA has undertaken, several in collaboration with the World Health Organization and the U.S. National Institutes of Health, to assess the current state of diagnosis-relevant research and to generate short- and long-term recommendations for research needed to enrich DSM-V and future psychiatric classifications. This research review and planning process has underscored widespread interest among nosologists in the US and globally regarding the potential benefits for research and clinical practice of incorporating a dimensional component into the existing categorical, or binary, classification system in the DSM. Toward this end, the APA and its partners convened an international conference in July 2006 to critically appraise the use of dimensional constructs in psychiatric diagnostic systems. Resultant papers appear in this issue of International Journal of Methods in Psychiatric Research and in a forthcoming monograph to be published by APA. PMID:17623390

  4. Different Imprinting Status of IGF-2 in Epithelial Ovarian Tumors

    Institute of Scientific and Technical Information of China (English)

    熊雅丽; 孙永玉; 李红发

    2002-01-01

    Summary: To explore whether the imprinting status of IGF-2 in the malignant epithelial ovarian tumors is different from that in benign tumors, the target sequences (DNA and RNA) which contain a polymorphism site for ApaI restriction endonuclease digestion were amplified with PCR and RT-PCR methods. Then the PCR/RT-PCR products were digested by ApaI. The IGF-2 transcriptional pattern came out from the results of endonucleases digestion. Among the 36 cases of benign epithelial ovarian tumors, 20 were heterozygous for ApaI locus and all showed genomic imprinting. While in the malignant group, 22 were heterozygous for ApaI locus but six were found to lose imprinting. Significant differences existed between the two groups (P<0. 05). Loss of imprinting of IGF-2 may serve as a marker for differentiating the malignant ovarian cancers from the benign ones. In a new field of molecular genetics, our research provides an experimental basis for genetic diagnosis and treatment of the ovarian cancers.

  5. Challenges in Social Communication in Asperger Syndrome and High-Functioning Autism

    Science.gov (United States)

    Rubin, Emily; Lennon, Laurie

    2004-01-01

    Despite the inclusion of Asperger syndrome in the Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition (DSM-IV) American Psychiatric Association [APA], 1994) 10 years ago, there is ongoing debate regarding its validity as a diagnostic construct, particularly relative to the diagnosis of autistic disorder when it is not accompanied…

  6. Citar documentos electrónicos. Revisión de propuestas y planteamiento de pautas generales

    OpenAIRE

    Marcos Mora, Mari Carmen

    2002-01-01

    Se recogen las propuestas de normalización de citas de documentos electrónicos de varios autores que a su vez se basan para desarrollarlas en los estilos publicados por la ISO, la APA y la MLA. Se ofrecen unas pautas generales de aplicación que suponen una unificación de las presentadas.

  7. Effects of paternal age and offspring cognitive ability in early adulthood on the risk of schizophrenia and related disorders

    DEFF Research Database (Denmark)

    Sørensen, Holger J; Pedersen, Carsten B; Nordentoft, Merete;

    2014-01-01

    Advanced paternal age (APA) and intelligence quotient (IQ) are both associated with the risk of schizophrenia spectrum disorder (SSD) in young adult offspring. We hypothesized that the offspring SSD risk gradient associated with paternal age is mediated by offspring IQ. We investigated joint and ...

  8. Peranan Departemen Sumber Daya Manusia Dalam Meningkatkan Efesiensi Dan Kinerja Karyawan Di Hotel JW Marriott Medan

    OpenAIRE

    Kemal, M. Arya

    2013-01-01

    Kemajuan ilmu pengetahuan dan tekhnologi di negara maju maupun negara berkembang sangat ditentukan oleh peranan dan perkembangan Departemen Sumberdaya Manusia. Fungsi utama Departemen Sumberdaya Manusia adalah melatih dan menyediakan karyawan yang kompeten dan professional yang berorientasi kepada kepuasan pelanggan atau tamu. Kompetensi adalah sebuah persaingan terhadap apa yang seseorang harus lakukan ditempat dimana ia bekerja untuk menunjukkan pengetahuan, kualitas, dan keterampilan yang ...

  9. Textual standardization and the DSM-5 "common language".

    Science.gov (United States)

    Kelly, Patty A

    2014-06-01

    In February 2010, the American Psychiatric Association (APA) launched their DSM-5 website with details about the development of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). The APA invited "the general public" to review the draft diagnostic criteria and provide written comments and suggestions. This revision marks the first time the APA has solicited public review of their diagnostic manual. This article analyzes reported speech on the DSM-5 draft diagnostic criteria for the classification Posttraumatic Stress Disorder. It demonstrates how textual standardization facilitates the cultural portability of the DSM-5 diagnostic criteria such that a community of speakers beyond the borders of the APA come to be seen as exemplary speakers, writers, and revisers of the professional style. Furthermore, analysis shows how co-authoring practices recontextualize the "voice" and persona of putative patient reported speech on Criterion D2. As a consequence of textual standardization, spoken discourse becomes recontextualized as the product of scientific inquiry and the organization of psychiatric knowledge. PMID:24682628

  10. Hubungan Faktor Sosial Ekonomi Petani Padi Sawah Dengan Tingkat Adopsi Teknologi Rumah Kompos (Studi Kasus : Desa Sei Buluh, Kecamatan Teluk Mengkudu, Kabupaten Serdang Bedagai)

    OpenAIRE

    Aceh, Rais

    2011-01-01

    Penelitian dilakukan untuk mengetahui tingkat adopsi petani padi sawah terhadap teknologi rumah kompos di daerah penelitian, mengetahui hubungan antara faktor sosial ekonomi petani (umur, tingkat pendidikan, lamanya berusahatani, frekuensi mengikuti penyuluhan, tingkat kosmopolitan, jumlah tanggungan keluarga, luas lahan, produksi dan produktivitas) dengan tingkat adopsi petani padi sawah terhadap teknologi rumah kompos di daerah penelitian, untuk mengetahui masalah masalah apa saja yang di...

  11. 77 FR 58492 - Prohibitions Governing Fire

    Science.gov (United States)

    2012-09-21

    ... public property exemption from public notice and comment rulemaking under the APA (July 24, 1971; 36 FR... Forest Service 36 CFR Part 261 RIN 0596-AD08 Prohibitions Governing Fire AGENCY: Forest Service, USDA... Fire. * * * * * (j) Operating or using any internal or external combustion engine without a...

  12. Auricular Point Acupressure to Manage Chronic Low Back Pain in Older Adults: A Randomized Controlled Pilot Study

    Directory of Open Access Journals (Sweden)

    Chao Hsing Yeh

    2014-01-01

    Full Text Available This prospective, randomized clinical trial (RCT pilot study was designed to (1 assess the feasibility and tolerability of an easily administered, auricular point acupressure (APA intervention and (2 provide an initial assessment of effect size as compared to a sham treatment. Thirty-seven subjects were randomized to receive either the real or sham APA treatment. All participants were treated once a week for 4 weeks. Self-report measures were obtained at baseline, weekly during treatment, at end-of-intervention (EOI, and at a 1-month follow-up. A dropout rate of 26% in the real APA group and 50% in the sham group was observed. The reduction in worst pain from baseline to EOI was 41% for the real and 5% for the sham group with a Cohen’s effect size of 1.22 P<0.00. Disability scores on the Roland Morris Disability Questionnaire (RMDQ decreased in the real group by 29% and were unchanged in the sham group (+3% P<0.00. Given the high dropout rate, results must be interpreted with caution; nevertheless, our results suggest that APA may provide an inexpensive and effective complementary approach for the management of back pain in older adults, and further study is warranted.

  13. Alternative polyadenylation and RNA-binding proteins.

    Science.gov (United States)

    Erson-Bensan, Ayse Elif

    2016-08-01

    Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs. To add further complexity, alternative polyadenylation (APA) emerges as a widespread mechanism to regulate gene expression by producing shorter or longer mRNA isoforms that differ in the length of their 3'-UTRs or even coding sequences. Resulting shorter mRNA isoforms generally lack cis-elements where trans-acting factors bind, and hence are differentially regulated compared with the longer isoforms. This review focuses on the RBPs involved in APA regulation and their action mechanisms on APA-generated isoforms. A better understanding of the complex interactions between APA and RBPs is promising for mechanistic and clinical implications including biomarker discovery and new therapeutic approaches. PMID:27208003

  14. Therapeutic effect of apatinib-loaded nanoparticles on diabetes-induced retinal vascular leakage

    Science.gov (United States)

    Jeong, Ji Hoon; Nguyen, Hong Khanh; Lee, Jung Eun; Suh, Wonhee

    2016-01-01

    Apatinib, a novel and selective inhibitor of vascular endothelial growth factor (VEGF) receptor 2, has been demonstrated recently to exhibit anticancer efficacy by inhibiting the VEGF signaling pathway. Given the importance of VEGF in retinal vascular leakage, the present study was designed to investigate whether apatinib-loaded polymeric nanoparticles inhibit VEGF-mediated retinal vascular hyperpermeability and block diabetes-induced retinal vascular leakage. For the delivery of water-insoluble apatinib, the drug was encapsulated in nanoparticles composed of human serum albumin (HSA)-conjugated polyethylene glycol (PEG). In vitro paracellular permeability and transendothelial electric resistance assays showed that apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles significantly inhibited VEGF-induced endothelial hyperpermeability in human retinal microvascular endothelial cells. In addition, they substantially reduced the VEGF-induced junctional loss and internalization of vascular endothelial-cadherin, a major component of endothelial junction complexes. In vivo intravitreal injection of Apa-HSA-PEG nanoparticles in mice blocked VEGF-induced retinal vascular leakage. These in vitro and in vivo data indicated that Apa-HSA-PEG nanoparticles efficiently blocked VEGF-induced breakdown of the blood–retinal barrier. In vivo experiments with streptozotocin-induced diabetic mice showed that an intravitreal injection of Apa-HSA-PEG nanoparticles substantially inhibited diabetes-induced retinal vascular leakage. These results demonstrated, for the first time, that apatinib-loaded nanoparticles may be a promising therapeutic agent for the prevention and treatment of diabetes-induced retinal vascular disorders. PMID:27462154

  15. Simultaneous description of conductance and thermopower in single-molecule junctions from many-body ab initio calculations

    DEFF Research Database (Denmark)

    Jin, Chengjun; Markussen, Troels; Thygesen, Kristian Sommer

    2014-01-01

    We investigate the electronic conductance and thermopower of a single-molecule junction consisting of bis-(4-aminophenyl) acetylene (B4APA) connected to gold electrodes. We use nonequilibrium Green's function methods in combination with density-functional theory (DFT) and the many-body GW...

  16. m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome.

    Science.gov (United States)

    Molinie, Benoit; Wang, Jinkai; Lim, Kok Seong; Hillebrand, Roman; Lu, Zhi-Xiang; Van Wittenberghe, Nicholas; Howard, Benjamin D; Daneshvar, Kaveh; Mullen, Alan C; Dedon, Peter; Xing, Yi; Giallourakis, Cosmas C

    2016-08-01

    N(6)-Methyladenosine (m(6)A) is a widespread, reversible chemical modification of RNA molecules, implicated in many aspects of RNA metabolism. Little quantitative information exists as to either how many transcript copies of particular genes are m(6)A modified ('m(6)A levels') or the relationship of m(6)A modification(s) to alternative RNA isoforms. To deconvolute the m(6)A epitranscriptome, we developed m(6)A-level and isoform-characterization sequencing (m(6)A-LAIC-seq). We found that cells exhibit a broad range of nonstoichiometric m(6)A levels with cell-type specificity. At the level of isoform characterization, we discovered widespread differences in the use of tandem alternative polyadenylation (APA) sites by methylated and nonmethylated transcript isoforms of individual genes. Strikingly, there is a strong bias for methylated transcripts to be coupled with proximal APA sites, resulting in shortened 3' untranslated regions, while nonmethylated transcript isoforms tend to use distal APA sites. m(6)A-LAIC-seq yields a new perspective on transcriptome complexity and links APA usage to m(6)A modifications. PMID:27376769

  17. Physical and genetic mapping of the genomes of five Mycoplasma hominis strains by pulsed-field gel electrophoresis

    DEFF Research Database (Denmark)

    Ladefoged, Søren; Christiansen, Gunna

    1992-01-01

    -field gel electrophoresis. All the ApaI, SmaI, BamHI, XhoI, and SalI restriction sites (total of 21 to 33 sites in each strain) were placed on the physical map, yielding an average resolution of 26 kb. The maps were constructed using three different approaches: (i) size determination of DNA fragments...

  18. 3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells.

    Directory of Open Access Journals (Sweden)

    Yonit Hoffman

    2016-02-01

    Full Text Available Most mammalian genes often feature alternative polyadenylation (APA sites and hence diverse 3'UTR lengths. Proliferating cells were reported to favor APA sites that result in shorter 3'UTRs. One consequence of such shortening is escape of mRNAs from targeting by microRNAs (miRNAs whose binding sites are eliminated. Such a mechanism might provide proliferation-related genes with an expression gain during normal or cancerous proliferation. Notably, miRNA sites tend to be more active when located near both ends of the 3'UTR compared to those located more centrally. Accordingly, miRNA sites located near the center of the full 3'UTR might become more active upon 3'UTR shortening. To address this conjecture we performed 3' sequencing to determine the 3' ends of all human UTRs in several cell lines. Remarkably, we found that conserved miRNA binding sites are preferentially enriched immediately upstream to APA sites, and this enrichment is more prominent in pro-differentiation/anti-proliferative genes. Binding sites of the miR17-92 cluster, upregulated in rapidly proliferating cells, are particularly enriched just upstream to APA sites, presumably conferring stronger inhibitory activity upon shortening. Thus 3'UTR shortening appears not only to enable escape from inhibition of growth promoting genes but also to potentiate repression of anti-proliferative genes.

  19. Are reactive thermoplastic polymers suitable for future wind turbine composite materials blades?

    DEFF Research Database (Denmark)

    Raghavalu Thirumalai, Durai Prabhakaran

    2014-01-01

    found that only two potential reactive thermoplastic resin systems qualify for different processing requirements for blade manufacturing. Hence, the article focuses on the issues with the use of reactive polymers like APA-6 (Caprolactam) and CBT (Cyclic Butylene Terephtalate) resin systems for composite...

  20. Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII

    DEFF Research Database (Denmark)

    Gbahou, F; Holst, B; Schwartz, T W

    2010-01-01

    Epitopes determining the agonist property of two structurally distinct selective ligands for the human bombesin receptor subtype 3 (BB3), [D-Tyr6,(R)-Apa11,Phe13, Nle14]-bombesin(6-14) (Pep-1) and Ac-Phe-Trp-Ala-His(TauBzl)-Nip-Gly-Arg-NH2 (Pep-2), were mapped through systematic mutagenesis of the...

  1. Modulation of motor excitability by metricality of tone sequences

    DEFF Research Database (Denmark)

    Cameron, David; Stewart, Lauren; Pearce, Marcus;

    2012-01-01

    amplitude. These results demonstrate that the pure metrical structure of an auditory rhythm presented as generic parametrically varied tone sequences can influence motor excitability but that the picture may be more complex for real recordings of musical pieces. (PsycINFO Database Record (c) 2013 APA, all...

  2. The Relationship of Tobacco Use With Gambling Problem Severity and Gambling Treatment Outcome

    DEFF Research Database (Denmark)

    Odlaug, Brian Lawrence; Stinchfield, Randy; Golberstein, Ezra;

    2013-01-01

    This study sought to examine the impact of tobacco use on gambling treatment. Pathological gambling (PG) is a psychiatric condition associated with significant financial, emotional, and psychosocial consequences. Elevated rates of nicotine dependence have been associated with increased gambling s....... (PsycINFO Database Record (c) 2012 APA, all rights reserved)....

  3. Acute antidepressant drug administration and autobiographical memory recall

    DEFF Research Database (Denmark)

    Papadatou-Pastou, Marietta; Miskowiak, Kamilla W; Williams, J Mark G;

    2012-01-01

    effect of reboxetine on emotional memory extends to recall of personally experienced events. Such effects may be relevant to the cognitive improvements found with recovery from depression and with the mechanism of action of contemporary antidepressant drugs. (PsycINFO Database Record (c) 2012 APA, all...

  4. One Week in January: A Register of Men from Late Antique Egypt

    DEFF Research Database (Denmark)

    Cromwell, Jennifer Adele

    2015-01-01

    various commodities, gardeners, and herders. Where toponyms can be identified, they are from the Hermopolite nome. It is argued that this register records the male visitors to the monastery of Apa Apollo at Bawit, near Hermopolis, during a period of one week in Tobe (January) in the seventh/eighth century...

  5. Rubric Use in Formative Assessment: A Detailed Behavioral Rubric Helps Students Improve Their Scientific Writing Skills

    Science.gov (United States)

    Greenberg, Kathleen P.

    2015-01-01

    A detailed rubric initially designed as a scoring instrument for grading APA-style empirical research reports was tested for its ability to help students improve their scientific writing skills. Students who used the rubric while preparing their reports wrote a higher quality report than did students who did not. Students also improved the quality…

  6. Kajian hukum terhadap Pengalokasian Lahan Untuk Fasilitas Umum diatas Hak Pengelolaan Untuk Kegiatan Perumahan (studi Pada Perumahan Plamo Garden dan Taman Harapan Indah di Kota Batam)

    OpenAIRE

    Maria, Candy Desita Paramitha

    2013-01-01

    Pihak Pengembang Perumahan yang telah memiliki lahan harus mengikuti persyaratan pembagian luasan persil seluruhnya (Building coverage), Bagian lahan yang diserahkan kepada Pemda tersebut akan di gunakan sebagai fasilitas demi kepentingan bersama penghuni dan juga penghijauan agar perumahan terlihat asri. Namun pada kenyataannya telah ditemukan pihak pengembang yang tidak memberikan apa yang seharusnya menjadi hak masyarakat kepada Pemerintah Kota dengan merubah fungsi yang tad...

  7. TINJAUAN HUKUM PENDAFTARAN ASET BERUPA TANAH OLEH PEMERINTAH KOTA GORONTALO

    OpenAIRE

    RAZAK BIYA, BAYU

    2014-01-01

    Tujuan penelitian ini adalah untuk mengetahui bagaimana pelaksanaan pendaftaran aset daerah yang berupa tanah di Pemerintah Kota Gorontalo dan untuk mengetahui faktor-faktor apa yang menjadi penghambat Pemerintah Kota Gorontalo dalam melaksanakan pendaftaran aset daerah yang berupa tanah. Penelitian ini bersifat penelitian lapangan dimana pengumpulan data dilakukan dengan metode wawancara terhadap beberapa pihak yang terkait denga...

  8. Peranan Komunikasi Antarpribadi Dalam Meningkatkan Kinerja Karyawan Di KFC Suzuya Binjai

    OpenAIRE

    Ismail

    2014-01-01

    Penelitian ini merupakan penelitian kualitatif dengan judul Peranan Komunikasi Antarpribadi dalam meningkatkan kinerja karyawan di KFC Suzuya Binjai. Adapun permasalahan penelitian penulis adalah bagaimanakah peranan komunikasi antarpribadi berperan terhadap peningkatan kinerja karyawan KFC Suzuya Binjai. Adapun yang menjadi tujuan penelitian ini adalah untuk mengetahui proses komunikasi antarpribadi pimpinan terhadap karyawan, untuk mengetahui hambatan-hambatan apa saja yang terjadi selama ...

  9. 77 FR 69761 - Regulated Navigation Area; Recovery Operations, the Port of New York and New Jersey, NJ and NY

    Science.gov (United States)

    2012-11-21

    ... INFORMATION: Table of Acronyms APA Administrative Procedure Act DHS Department of Homeland Security FR Federal... the January 17, 2008, issue of the Federal Register (73 FR 3316). 4. Public Meeting We do not now plan... large machinery and construction vessel operations above and upon the navigable waters of the Port...

  10. Report of the Ethics Committee, 2010

    Science.gov (United States)

    American Psychologist, 2011

    2011-01-01

    In accordance with the bylaws of the American Psychological Association (APA), the Ethics Committee reports regularly to the membership regarding the number and types of ethics matters investigated and the major programs undertaken. In 2010, ethics adjudication, ethics education and consultation, and special projects were activities of the Ethics…

  11. Knowing What We Do Not Know about Sexual Orientation Change Efforts

    Science.gov (United States)

    Rosik, Christopher H.; Jones, Stanton L.; Byrd, A. Dean

    2012-01-01

    Comments on the original article, "Guidelines for psychological practice with lesbian, gay, and bisexual clients," by the American Psychological Association (see record 2011-19419-001). The present authors note that the APA has provided a very helpful document for those who do clinical work with individuals experiencing same-sex attractions.…

  12. Top 20 Psychological Principles for PK-12 Education

    Science.gov (United States)

    Lucariello, Joan M.; Nastasi, Bonnie K.; Dwyer, Carol; Skiba, Russell; DeMarie, Darlene; Anderman, Eric M.

    2016-01-01

    This article describes an initiative undertaken by a coalition of psychologists (Coalition for Psychology in Schools and Education) from the American Psychological Association (APA) to identify the top 20 principles from psychological science relevant to teaching and learning in the classroom. This article identifies these principles and their…

  13. 2011 Annual Report of the American Psychological Association

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    As we have throughout the association's history, we focused in 2011 on multiple initiatives--all designed to further, support, and communicate the important work that psychologists do. This year we had the benefit of APA's first-ever strategic plan as well as funding for the following seven initiatives that are specifically designed to execute the…

  14. 78 FR 11939 - Social Security Ruling, SSR 13-2p.; Titles II and XVI: Evaluating Cases Involving Drug Addiction...

    Science.gov (United States)

    2013-02-20

    ...) published by the American Psychiatric Association.\\3\\ See Question 4. In general, the DSM defines Substance... or distress.\\4\\ \\3\\ American Psychiatric Association (APA), Diagnostic and Statistical Manual of..., psychologist, or other appropriate acceptable medical source based on examination of the claimant....

  15. 2009 Annual Report of the American Psychological Association

    Science.gov (United States)

    American Psychologist, 2010

    2010-01-01

    This annual report of the American Psychological Association (APA) describes the association's activities and accomplishments in 2009. It describes strides made toward the goal of infusing psychology into the health care marketplace and of bringing psychology--and the unique skills of psychologists--to the attention of the public. This report aims…

  16. Shift of the Muscular Inhibition Latency during On-Line Acquisition of Anticipatory Postural Adjustments

    Science.gov (United States)

    Barlaam, Fanny; Vaugoyeau, Marianne; Fortin, Carole; Assaiante, Christine; Schmitz, Christina

    2016-01-01

    During action, Anticipatory Postural Adjustments (APAs) cancel the consequences of a movement on postural stabilization. Their muscular expression is characterized by early changes in the activity of the postural muscles, before the movement begins. To explore the mechanisms enabling the acquisition of APAs, a learning paradigm was designed in which the voluntary lifting of a load with one hand triggered the unloading of another load suspended below the contralateral forearm. The aim of this study was to investigate changes in the muscular expression that uncovers the progressive learning of new APAs. A trial-by-trial analysis of kinematic and electromyographic signals recorded on the right arm was conducted in twelve adults through six sessions of learning. Kinematic results reported an enhancement of the postural stabilization across learning. The main EMG pattern found during learning consisted of a flexor inhibition, where latency was shifted towards an earlier occurrence in parallel with the improvement of the postural performance. A linear regression analysis conducted between the inhibition latency and the maximal amplitude of elbow rotation showed that the earlier the inhibition onset, the better the postural stabilization. This study revealed that the progressive shift of the postural flexor inhibition latency could be considered as a reliable neurophysiological marker of the progressive learning of new APAs. Importantly, this marker could be used to track motor learning abnormalities in pathology. We relate our findings to the update of a forward predictive model of action, defined as a system that predicts beforehand the consequences of the action on posture. PMID:27192604

  17. Charles L. Brewer Award for Distinguished Teaching of Psychology.

    Science.gov (United States)

    2008-01-01

    The American Psychological Foundation (APF) Charles L. Brewer Distinguished Teaching of Psychology Award recognizes an outstanding career contribution to the teaching of psychology. The 2008 recipient of the Distinguished Teaching Award is Scott Plous. A citation, biography, and selected bibliography for Scott Plous are provided in this article. (PsycINFO Database Record (c) 2008 APA, all rights reserved). PMID:18665671

  18. 78 FR 49921 - Safety Zone; Thunder on the Niagara, Niagara River, North Tonawanda, NY

    Science.gov (United States)

    2013-08-16

    ... DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking TFR... Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without... LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues to read as follows: Authority:...

  19. Stephen M. Weiss: award for distinguished professional contributions to applied research.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Stephen M. Weiss, who received the Award for Distinguished Professional Contributions to Applied Research "for his work as an internationally recognized leader in the fields of health psychology and behavioral medicine." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115838

  20. Marcia K. Johnson: 2006 award for distinguished scientific contributions.

    Science.gov (United States)

    2006-11-01

    Presents the citation to Marcia K. Johnson, who received the Award for Distinguished Scientific Contributions "for raising and illuminating fundamental questions about the cognitive and neural processes that constitute the subjective experience of mental life." A brief profile and a selected bibliography, as well as Johnson's award address, entitled Memory and Reality, accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115807

  1. 76 FR 64005 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-10-17

    ... Policies and Procedures (44 FR 11034; February 26,1979); and (3) does not warrant preparation of a... Center (APA-200), FAA Headquarters Building, 800 Independence Avenue, SW., Washington, DC 20591; or 2... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  2. John P. Campbell: award for distinguished scientific applications of psychology.

    Science.gov (United States)

    2006-11-01

    Presents the citation for John P. Campbell who received Award for Distinguished Scientific Applications of Psychology "for his many different contributions to the field of industrial and organizational (I/O) psychology." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115812

  3. Martin E. P. Seligman: 2006 award for distinguished scientific contributions.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Martin E. P. Seligman, who received the Award for Distinguished Scientific Contributions "for a career spent charging creatively ahead of his field and then pulling his colleagues along." A brief profile and a selected bibliography, as well as the award address, Positive Psychotherapy, accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115809

  4. Selected Bibliography (259 ref.) of Ojibwa and Other Native American Related Research Concerning Psychoeducational Assessment and Intervention (as well as Related Historical, Cultural, Legal, Economic, and Medical Factors).

    Science.gov (United States)

    McShane, Damian, Comp.

    Utilizing ERIC (Educational Resources Information Center), DAI (Dissertation Abstracts International), and APA (American Psychological Association) computer search resources and library resources in Tennessee, Minnesota, Wisconsin, and Canada, this bibliography contains 259 citations pertaining to Ojibwa (Chippewa) and other Native Americans.…

  5. Thomas J. Fagan: award for distinguished professional contributions to practice in the public sector.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Thomas J. Fagan, who received the Award for Distinguished Professional Contributions to Practice in the Public Sector "for his service as a leader in correctional psychology." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115843

  6. 78 FR 62329 - Special Local Regulation; Tennessee River, Miles 255.0 to 256.5, Florence, AL

    Science.gov (United States)

    2013-10-17

    ... Security FR Federal Register NPRM Notice of Proposed Rulemaking A. Regulatory History and Information The... pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This... ON NAVIGABLE WATERS 0 1. The authority citation for Part 100 continues to read as follows:...

  7. 75 FR 80680 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-12-23

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters... citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40106, 40113,...

  8. 78 FR 59808 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-09-30

    ... ``significant rule '' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26,1979); and (3) does... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue SW... authority citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103,...

  9. Seth D. Pollak: award for distinguished scientific early career contributions to psychology.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Seth D. Pollak, who received the Award for Distinguished Scientific Early Career Contributions to Psychology (developmental psychology) "for his research on the mechanisms of emotional development using an innovative combination of methods from psychophysics, neuroscience, and behavioral endocrinology." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115817

  10. 78 FR 36429 - Safety Zone; Private Party Fireworks; Lake Michigan, Chicago, IL

    Science.gov (United States)

    2013-06-18

    ...-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal... pursuant to authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This... AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for Part 165 continues to read as...

  11. The Missing Link: The Lack of Citations and Copyright Notices in Multimedia Presentations

    Science.gov (United States)

    Huffman, Stephanie

    2010-01-01

    Many of the projects and assignments we have our students complete for our classes include a multimedia presentation. Why are we not teaching our students how to cite their sources for these presentations? Writing style (APA, MLA, or Chicago) does not matter. Regardless of whether it is a paper or multimedia presentation students should always…

  12. 77 FR 70372 - Drawbridge Operation Regulation; Shark River (South Channel), Avon Township, NJ

    Science.gov (United States)

    2012-11-26

    ... FR Federal Register NPRM Notice of Proposed Rulemaking Sec. Section Symbol U.S.C. United States Code... Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior...: PART 117--DRAWBRIDGE OPERATION REGULATIONS 0 1. The authority citation for part 117 continues to...

  13. Anthony D. Wagner: award for distinguished scientific early career contributions to psychology.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Anthony D. Wagner, who received the Award for Distinguished Scientific Early Career Contributions to Psychology (cognition and human learning) "for outstanding and innovative research on the neural basis of memory and executive control." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115819

  14. 78 FR 7652 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-02-04

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  15. 75 FR 32655 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-06-09

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a... and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  16. 78 FR 37971 - Security Zone; Naval Exercise; Pacific Ocean, Coronado, CA

    Science.gov (United States)

    2013-06-25

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without... authority citation for part 165 continues to read as follows: Authority: 33 U.S.C. 1231; 46 U.S.C....

  17. 76 FR 77111 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-12-12

    ... ``significant rule '' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979) ; and (3... obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue... authority citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103,...

  18. 78 FR 48609 - Safety Zone; James River; Newport News, VA

    Science.gov (United States)

    2013-08-09

    ... INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior... authority citation for part 165 continues to read as follows: Authority: 33 U.S.C. 1231; 46 U.S.C....

  19. 78 FR 6728 - Drawbridge Operation Regulation; Long Island, New York Inland Waterway From East Rockaway Inlet...

    Science.gov (United States)

    2013-01-31

    ... Federal Regulations DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an... REGULATIONS 0 1. The authority citation for part 117 continues to read as follows: Authority: 33 U.S.C....

  20. 78 FR 7650 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-02-04

    ... ``significant rule '' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3... from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue SW... authority citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103,...

  1. 78 FR 30765 - Safety Zone; Bay Village Independence Day Fireworks, Lake Erie, Bay Village, OH

    Science.gov (United States)

    2013-05-23

    ... of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking TFR Temporary Final Rule... Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior...--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues...

  2. 78 FR 49923 - Safety Zone; D-Day Conneaut, Lake Erie, Conneaut, OH

    Science.gov (United States)

    2013-08-16

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision... LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues to read as follows: Authority:...

  3. 77 FR 56115 - Safety Zone for Fireworks Display, Potomac River, National Harbor Access Channel; Oxon Hill, MD

    Science.gov (United States)

    2012-09-12

    ...: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed... Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior... LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues to read as follows: Authority:...

  4. 77 FR 12454 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-03-01

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... citation for part 97 continues to read as follows: Authority: 49 U.S.C. 106(g), 40103, 40106, 40113,...

  5. 77 FR 33085 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-06-05

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  6. 78 FR 30762 - Safety Zone; 2013 Fish Festival Fireworks, Lake Erie, Vermilion, OH

    Science.gov (United States)

    2013-05-23

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... authority under section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision...--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues...

  7. 78 FR 60220 - Safety Zone; Fireworks Display, Willamette River, Oregon City, OR

    Science.gov (United States)

    2013-10-01

    ... DHS Department of Homeland Security FR Federal Register NPRM Notice of Proposed Rulemaking A... Act ] (APA) (5 U.S.C. 553(b)). This provision authorizes an agency to issue a rule without prior...--REGULATED NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues...

  8. 76 FR 77113 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-12-12

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  9. Angela Bryan: award for distinguished scientific early career contributions to psychology.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Angela Bryan, who received the Award for Distinguished Scientific Early Career Contributions to Psychology (health psychology) "for her outstanding theoretical and applied research on health behavior change." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115816

  10. 75 FR 42310 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-07-21

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  11. Brian J. Scholl: award for distinguished scientific early career contributions to psychology.

    Science.gov (United States)

    2006-11-01

    Presents the citation for Brian J. Scholl, who received the Award for Distinguished Scientific Early Career Contributions to Psychology "for his brilliantly creative and sweepingly broad research program that addresses the hard questions in cognitive science." A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved). PMID:17115818

  12. 76 FR 18381 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-04-04

    ... Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of a..., individual SIAP and Takeoff Minimums and ODP copies may be obtained from: 1. FAA Public Inquiry Center (APA... specified, as follows: PART 97--STANDARD INSTRUMENT APPROACH PROCEDURES 0 1. The authority citation for...

  13. 78 FR 669 - Safety Zone; Hampton Harbor Channel Obstruction, Hampton Harbor; Hampton, NH

    Science.gov (United States)

    2013-01-04

    ...) 366-9826. SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal... section 4(a) of the Administrative Procedure Act (APA) (5 U.S.C. 553(b)). This provision authorizes an... NAVIGATION AREAS AND LIMITED ACCESS AREAS 0 1. The authority citation for part 165 continues to read...

  14. Examining the Personal-Professional Distinction: Ethics Codes and the Difficulty of Drawing a Boundary

    Science.gov (United States)

    Pipes, Randolph B.; Holstein, Jaymee E.; Aguirre, Maria G.

    2005-01-01

    The Ethics Code of the American Psychological Association (APA) applies to the professional role behaviors of members and not to their personal behavior. This article discusses some of the difficulties inherent in drawing distinctions between the personal and the professional. Consideration is given to the importance of clarifying public…

  15. Preparing the New Professoriate: What Courses Should They Be Ready to Teach?

    Science.gov (United States)

    Irons, Jessica G.; Buskist, William

    2008-01-01

    We examined job advertisements published in the September and October 2006 issues of the APA Monitor and APS Observer for courses that psychology departments requested successful applicants for assistant professor openings to teach. We found that 4 courses accounted for 45% of all courses so listed: research methods, introductory psychology,…

  16. ANALISA KEPUASAN PELANGGAN SEBAGAI UPAYA PENINGKATAN KUALITAS PELAYANAN DI SF DIGITAL PHOTO SERVICE

    OpenAIRE

    Heru Kesumajayansyah; M. Ari Budi Yuwono

    2014-01-01

    Ditengah persaingan saat ini yang sangat ketat menuntut perusahaan harus dapat meningkatkan kualitas pelayanannya agar dapat terus mempertahankan pelanggan yang dimilikinya. Tujuan dari penelitian ini yaitu untuk mengetahui mengetahui perbedaan (gap) antara persepsi pelanggan dengan harapan pelanggan terhadap kualitas pelayanan, mendapatkan gambaran tentang atribut kualitas apa yang berpengaruh terhadap kualitas pelayanan, dan mengetahui tingkat kepuasan pelanggan terhadap kualitas pelayanan ...

  17. The Role of Educational Psychology in Teacher Education: Three Challenges for Educational Psychologists

    Science.gov (United States)

    Patrick, Helen; Anderman, Lynley H.; Bruening, Paige S.; Duffin, Lisa C.

    2011-01-01

    We argue that this is a crucial time for educational psychology as a field to refocus its attention on the evidence base for its contribution to teacher education. In revisiting the recommendations of the APA Division 15 committee charged with examining the role of educational psychology in teacher education (Anderson et al., 1995), we note…

  18. Model Act for State Licensure of Psychologists

    Science.gov (United States)

    American Psychologist, 2011

    2011-01-01

    As APA policy, the Model Act for State Licensure of Psychologists serves as a prototype for drafting state legislation regulating the practice of psychology. State legislatures are encouraged to use the language of this document and the policies that it espouses as the model for their own state licensure laws. Inevitably each state law will…

  19. Residual Strains in Thick Thermoplastic Composites: an Experimental Approach

    NARCIS (Netherlands)

    Parlevliet, P.P.

    2010-01-01

    Thermoplastic composites are currently investigated for application in windmill turbine blades for their recyclability. A suitable manufacturing technology for these thick structures is liquid resin infusion followed by in-situ polymerisation of Anionic Polyamide-6 (APA-6). During manufacturing of t

  20. Association between vitamin D receptor gene polymorphisms and chronic periodontitis among Libyans

    Directory of Open Access Journals (Sweden)

    Mouna M. El Jilani

    2015-03-01

    Full Text Available Background: Chronic periodontitis (CP is a common oral disease characterized by inflammation in the supporting tissue of the teeth ‘the periodontium’, periodontal attachment loss, and alveolar bone loss. The disease has a microbial etiology; however, recent findings suggest that the genetic factors, such as vitamin D receptor (VDR gene polymorphisms, have also been included. Aim: Investigation of the relationship between VDR gene polymorphisms and CP among Libyans. Materials and methods: In this study, we examined 196 unrelated Libyans between the ages of 25 and 65 years, including 99 patients and 97 controls. An oral examination based on Ramfjord Index was performed at different dental clinics in Tripoli and information were collected using a self-reported questionnaire. DNA was extracted from buccal swabs; the VDR ApaI, BsmI, and FokI polymorphisms were genotyped using polymerase chain reaction and were sequenced using Sanger Method. Results: A significant difference in the newly detected ApaI SNP C/T rs#731236 was found (p=0.022, whereas no significant differences were found in ApaI SNP G/T rs#7975232, BsmI SNP A/G rs#1544410, and FokI SNP A/G rs#2228570 between patients and controls (p=0.939, 0.466, 0.239, respectively. Conclusion: VDR ApaI SNP C/T rs#731236 may be related to the risk of CP in the Libyan population.

  1. Matrix Summaries Improve Research Reports: Secondary Analyses Using Published Literature

    Science.gov (United States)

    Zientek, Linda Reichwein; Thompson, Bruce

    2009-01-01

    Correlation matrices and standard deviations are the building blocks of many of the commonly conducted analyses in published research, and AERA and APA reporting standards recommend their inclusion when reporting research results. The authors argue that the inclusion of correlation/covariance matrices, standard deviations, and means can enhance…

  2. DSM-5 ASD Moves Forward into the Past

    Science.gov (United States)

    Tsai, Luke Y.; Ghaziuddin, Mohammad

    2014-01-01

    The fifth edition of the diagnostic and statistical manual of mental disorders (DSM-5) (APA in diagnostic and statistical manual of mental disorders, Author, Washington, 2013) has decided to merge the subtypes of pervasive developmental disorders into a single category of autism spectrum disorder (ASD) on the assumption that they cannot be…

  3. DSM-V筹备项目进行得怎样了?

    Institute of Scientific and Technical Information of China (English)

    舒伟洁

    2008-01-01

    @@ 精神疾病诊断与统计手册(The Diagnostic and Statistical Manual of Mental Disorders,DSM)由美国精神科学会(American Psychiatric Association,APA)出版,是美国等国最常使用来诊断精神疾病的指导手册.

  4. Meet the New (and Improved?) DSM-5

    Science.gov (United States)

    Hart, Shelly R.; Pate, Christine M.; Brock, Stephen E.

    2013-01-01

    Clinical diagnosis is not a typical school psychologist activity. However, changes to the "Diagnostic and Statistical Manual of Mental Disorders" (DSM), the framework for diagnosis put forth by the American Psychiatric Association (APA), are important to consider. First published in 1952, major revisions are being proposed for this new edition…

  5. Redefining Autism Spectrum Disorder Using DSM-5: The Implications of the Proposed DSM-5 Criteria for Autism Spectrum Disorders

    Science.gov (United States)

    Young, Robyn L.; Rodi, Melissa L.

    2014-01-01

    A number of changes were made to pervasive developmental disorders (PDDs) in the recently released diagnostic and statistical manual of mental disorders (APA, "Diagnostic and statistical manual of mental disorders," American Psychiatric Publishing, Arlington, VA, 2013). Of the 210 participants in the present study who met DSM-IV-TR…

  6. Association of vitamin D receptor and estrogen receptor-α gene polymorphism with peak bone mass and bone size in Chinese women

    Institute of Scientific and Technical Information of China (English)

    Yue-juan QIN; Zhen-lin ZHANG; Qi-ren HUANG; Jin-wei HE; Yun-qiu HU; Qi ZHOU; Jing-hui LU; Miao LI; Yu-juan LIU

    2004-01-01

    AIM: To investigate if vitamin D receptor (VDR) gene Apa I polymorphism and estrogen receptor-α (ER-α) gene Pvu II, Xba I polymorphisms are related to bone mineral density (BMD), bone mineral content (BMC) and bone size in premenopausal Chinese women. METHODS: The VDR Apa I genotype and ER-α Pvu II, Xba I genotype were determined by PCR-restriction fragment length polymorphism (RFLP) in 493 unrelated healthy women aged 20-40 years of Hah nationality in Shanghai city. BMD (g/cm2), BMC (g), and bone areal size (BAS, cm2) at lumbar spine 1-4 (L1-4) and proximal femur (femoral neck, trochanter and Ward's triangle) were measured by duel-energy X-ray absorptionmetry. RESULTS: All allele frequencies did not deviate from Hardy-Weinberg equilibrium. After phenotypes were adjusted for age, height, and weight, a significant association was found between VDR Apa I genotype and BMC variation at L1-4 and Ward's triangle (P<0.05), but not in BMD or BAS at lumbar spine and proximal femur.ER-α Pvu II, Xba I genotype was not related to BMC, BMD, and BAS at all sites. CONCLUSION: The study suggested that Apa I polymorphism in VDR gene may influence on attainment and maintenance of peak bone mass in premenopausal Chinese women.

  7. Time Management, Passion, and Collaboration: A Qualitative Study of Highly Research Productive Counseling Psychologists

    Science.gov (United States)

    Duffy, Ryan D.; Torrey, Carrie L.; Bott, Elizabeth M.; Allan, Blake A.; Schlosser, Lewis Z.

    2013-01-01

    The present study interviewed 17 of the most research-productive counseling psychologists within APA-accredited counseling psychology programs. Using Consensual Qualitative Research, seven domains emerged from the interviews: root of productivity, personality characteristics, productivity strategies, work environment, nonwork life, impact, and…

  8. Allegation rates in forensic child abuse investigations: Comparing the Revised and Standard NICHD Protocols

    OpenAIRE

    Lamb, Michael E.; Katz, Carmit

    2014-01-01

    This is the author accepted manuscript. The final version of this article can be found here: doi: 10.1037/a0037391. This article may not exactly replicate the final version published in the APA journal. It is not the copy of record. ? 2014 American Psychological Association.

  9. Asian Pacific American Women in Higher Education: Claiming Visibility and Voice [and] Executive Summary.

    Science.gov (United States)

    Hune, Shirley

    This report examines the literature on the status of Asian Pacific American (APA) women and is based on a review of research studies, campus climate and diversity reports, focus group and individual interviews representing a range of colleges and universities, and the author's own observations in academe over two decades. The report finds that APA…

  10. Adapted Physical Activity Programme and Self-Perception in Obese Adolescents with Intellectual Disability: Between Morphological Awareness and Positive Illusory Bias

    Science.gov (United States)

    Salaun, Laureline; Reynes, Eric; Berthouze-Aranda, Sophie E.

    2014-01-01

    Background: In adolescents with intellectual disability, the management of obesity is a crucial issue, yet also quite complex because of their particular perception of themselves. This study investigated the relationship between self-perception variables and morphological variables and their changes after a 9-month Adapted Physical Activity (APA)…

  11. 76 FR 30509 - Court Orders and Legal Processes Affecting Thrift Savings Plan Accounts

    Science.gov (United States)

    2011-05-26

    ... character. As a result, no notice and comment period is required by the Administrative Procedure Act. See 5... finalize the process by which TSP accounts may be garnished efficiently--consistent with law and regulation..., no notice and comment period is required by the Administrative Procedure Act (APA). See 5 U.S.C....

  12. Favorite Activities for the Teaching of Psychology

    Science.gov (United States)

    Benjamin, Ludy T., Jr., Ed.

    2008-01-01

    The most popular activities from APA's successful "Activities Handbooks for the Teaching of Psychology" are gathered together and updated in this book of teachers' favorites. The lesson plans, which encourage active learning and involve the whole class, have stood the test of time and proven themselves to be entertaining, effective, and easy to…

  13. Ethel Tobach (1921-2015).

    Science.gov (United States)

    Greenberg, Gary

    2016-01-01

    With the passing of Ethel Tobach, the world of psychology has lost one of its few remaining giants. While her death brings to an end an important era in 20th-century comparative psychology, her contributions went beyond her research specialty into leadership and advocacy roles where she also had a substantial impact. Ethel's professional work and societal work were well recognized and often intertwined. Her many awards included the Kurt Lewin Award (1993) from Division 9 of the American Psychological Association (APA; Society for the Psychological Study of Social Issues), for "outstanding contributions to the development and integration of psychological research and social action." She served as president of APA Division 6 (1984 -1985, Comparative and Physiological Psychology) and APA's Division 48, (2004, the Society for the Study of Peace, Conflict, and Violence). Her professional contributions were acknowledged by being awarded the APA's Gold Medal Award for Lifetime Achievement in Psychology in the Public Interest (2003). In addition to a corpus of research publications and essays on various aspects of psychology, she is known for coediting several important books. PMID:26766768

  14. Report of the Ethics Committee, 2008

    Science.gov (United States)

    American Psychologist, 2009

    2009-01-01

    In accordance with the bylaws of the American Psychological Association (APA), the Ethics Committee reports regularly to the membership regarding the number and types of ethics complaints investigated and the major programs undertaken. In 2008, ethics adjudication, ethics education and consultation, convention programs, ethics publications,…

  15. Report of the Ethics Committee, 2009

    Science.gov (United States)

    American Psychologist, 2010

    2010-01-01

    In accordance with the bylaws of the American Psychological Association (APA), the Ethics Committee reports regularly to the membership regarding the number and types of ethics complaints investigated and the major programs undertaken. This article is a summary of the talks and workshops of 2009, ethics adjudication, ethics education and…

  16. Poly(A) code analyses reveal key determinants for tissue-specific mRNA alternative polyadenylation.

    Science.gov (United States)

    Weng, Lingjie; Li, Yi; Xie, Xiaohui; Shi, Yongsheng

    2016-06-01

    mRNA alternative polyadenylation (APA) is a critical mechanism for post-transcriptional gene regulation and is often regulated in a tissue- and/or developmental stage-specific manner. An ultimate goal for the APA field has been to be able to computationally predict APA profiles under different physiological or pathological conditions. As a first step toward this goal, we have assembled a poly(A) code for predicting tissue-specific poly(A) sites (PASs). Based on a compendium of over 600 features that have known or potential roles in PAS selection, we have generated and refined a machine-learning algorithm using multiple high-throughput sequencing-based data sets of tissue-specific and constitutive PASs. This code can predict tissue-specific PASs with >85% accuracy. Importantly, by analyzing the prediction performance based on different RNA features, we found that PAS context, including the distance between alternative PASs and the relative position of a PAS within the gene, is a key feature for determining the susceptibility of a PAS to tissue-specific regulation. Our poly(A) code provides a useful tool for not only predicting tissue-specific APA regulation, but also for studying its underlying molecular mechanisms. PMID:27095026

  17. Integrating Science in Applied Psychology Programs: A Student-Operated Journal

    Science.gov (United States)

    Antonius, Daniel; Brown, Adam D.; Todman, McWelling; Safran, Jeremy D.

    2007-01-01

    As a requirement of APA accreditation, many PhD programs in applied psychology subscribe to some variant of the scientist-practitioner model. However, critics have argued that integrating science into an applied psychology curriculum may be too challenging a task. This article describes the development of The New School Psychology Bulletin, a…

  18. Analisa Chemical Oxygen Demand (COD) Pada Air Limbah Dengan Metode Spektrofotometri Portable.

    OpenAIRE

    Utami, Derma Sari

    2011-01-01

    Pencemaran air disebabkan oleh komponen-komponen anorganik dan organik yang berasal dari kegiatan manusia seperti industri maupun buangan domestik diantaranya pembuangan limbah yang sangat berbahaya, dimana pencemaran merupakan kehadiran sesuatu (senyawa, zat kimia, materi, radiasi, suara, energi, atau apa saja) yang dapat mengakibatkan penyimpangan dari komposisi normal terhadap lingkungan.

  19. The Relationships between Homophobic Attitudes and Religiosity among Turkish Physical Education Teacher Majors

    Science.gov (United States)

    Sarac, Leyla

    2012-01-01

    Background: The American Psychiatric Association (APA) removed homosexuality from its official list of mental disorders in 1973. However, homosexuals face continuous discrimination in society. Studies have been conducted on societal attitudes toward homosexuals, and most of this research has focused on factors such as gender, educational level,…

  20. 美国心理协会参与修订《国际伤残分类标准》

    Institute of Scientific and Technical Information of China (English)

    吴今

    1997-01-01

    @@ 最近,世界卫生组织邀请美国心理协会(APA)参与(International Classification of Impairments,Dis-abilities and Handicaps,ICIDH)的修订工作,这给心理学界提供了一个难得的机会.

  1. Green Legacy of a Tibetan Village

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    When he finally reached the tittle Tibetan village hidden deep in the emerald mountains by the Tongtian River, on the upper reaches of the Yangtze River, Jeff Soule, policy director of the American Planning Association (APA), looked around with shining eyes.

  2. Tourette Syndrome: A Collaborative Approach Focused on Empowering Students, Families and Teachers

    Science.gov (United States)

    Christner, Beth; Dieker, Lisa A.

    2008-01-01

    Tourette syndrome (TS) is a neurobiological disorder marked by a wide range of involuntary motor and vocal movements and sounds called "tics" (American Psychiatric Association, APA, 2000). This syndrome is frequently misunderstood and difficult to diagnose (Chamberlain, 2003). Recent television shows featuring the topic of TS such as "The Oprah…

  3. Psychology Ethics in Introductory Psychology Textbooks

    Science.gov (United States)

    Zucchero, Renee' A.

    2011-01-01

    Previous research revealed that introductory psychology textbooks included limited information about psychology ethics. This study reviewed 48 current introductory psychology textbooks for research and other APA ethics content. These textbooks included slightly more total ethics content and were more thorough in their review of research ethics…

  4. Characteristics of Programs That Maximize Psychology Major Success

    Science.gov (United States)

    Stoloff, Michael L.; Good, Megan Rodgers; Smith, Kristen L.; Brewster, JoAnne

    2015-01-01

    We conducted a national survey of psychology department chairs, and, based on their responses, we concluded that psychology programs differ in the number of students enrolled in various types of classes; the degree of focus on each of the goals recommended by the "American Psychological Association (APA) Guidelines for an Undergraduate…

  5. Social justice and the politics of recognition.

    Science.gov (United States)

    Arfken, Michael

    2013-09-01

    Comments on the original article, "Psychology and social justice: Why we do what we do" by M. J. T. Vasquez (see record 2012-18676-002). Vasquez pointed to numerous initiatives and task forces that the American Psychological Association (APA) has established to address the marginalization and subordination of various groups. There is little doubt that the concerns addressed by these initiatives and task forces are important and play a central role in the development of a just society. Although Vasquez noted that "social realities are important determinants of distress" she failed to appreciate the extent to which our social relations emerge against the background of specific political and economic structures. The cost of this oversight is the perpetuation of a politics of recognition that does little to address the economic inequalities that are a defining feature of unjust societies. Were APA to restrict its attention to psychological distress or access to resources, it would place APA in the service of maintaining rather than transforming the existing structure of society. APA should consider developing initiatives and task forces to investigate the role that capitalism plays in the perpetuation of inequality and exploitation. It may also be time to reflect on why an institution that claims to be dedicated to social justice has had so little to say about one of the dominant features of modern society. PMID:24016125

  6. Plagio

    OpenAIRE

    Rosalynn Argelia CAMPOS ORTUÑO; Erla Mariela MORALES MORGADO; Yang, Lingling

    2014-01-01

    Resumen en español Resumen en inglés 1. El plagio. 2. Por qué evitar el plagio. 3. Tipos de plagio. 4. No plagiar a otros Se presenta el concepto y casos de plagio, complementado con vídeos y ejercicios de refuerzo sobre el uso adecuado de las normas APA.

  7. Age Differences in Personality Structure: A Cluster Analytic Approach

    Science.gov (United States)

    Costa, Paul T., Jr.; McCrae, Robert R.

    1976-01-01

    Presented at the 81st APA Convention, Montreal, 1973, this study showed how a cluster analytic approach was used to determine age differences in personality measured by the Sixteen Personality Factor Questionnaire (16PF). Subjects were 969 adult male volunteers, 25 to 34, 35 to 54, and 55 to 82. Openness to experience showed age-related…

  8. Effects of Teacher Consultation on Evidence-Based Classroom Management Strategies: Teacher and Student Behavior

    Science.gov (United States)

    Funk, Kristin M.

    2013-01-01

    The American Psychological Association (APA) conducted the online 2005-2006 Teacher Needs Survey wherein 52% of first year teachers, 28% of teachers with two to five years of experience, and 26% of teachers with 6 to 10 years experience ranked classroom management as their greatest need. Difficulty managing student behaviors leads to higher stress…

  9. GSFC contamination monitors for Space Station

    Science.gov (United States)

    Carosso, P. A.; Tveekrem, J. L.; Coopersmith, J. D.

    1988-01-01

    This paper describes the Work Package 3 activities in the area of neutral contamination monitoring for the Space Station. Goddard Space Flight Center's responsibilities include the development of the Attached Payload Accommodations Equipment (APAE), the Polar Orbiting Platform (POP), and the Flight Telerobotic Servicer (FTS). GSFC will also develop the Customer Servicing Facility (CSF) in Phase 2 of the Space Station.

  10. Thermoplastic Composite Wind Turbine Blades: An Integrated Design Approach

    NARCIS (Netherlands)

    Joncas, S.

    2010-01-01

    This thesis proposes a new structural design concept for future large wind turbine blades based on fully recyclable thermoplastic composites (TPC). With respect to material properties, cost and processing, reactively processed anionic polyamide-6 (APA-6) has been identified as the most promising the

  11. The RRC Mandate for Residency Programs to Demonstrate Psychodynamic Psychotherapy Competency among Residents: A Debate

    Science.gov (United States)

    Yager, Joel; Mellman, Lisa; Rubin, Eugene; Tasman, Allan

    2005-01-01

    Objective: The Residency Review Committee (RRC) requirement that residents must achieve competency in psychodynamic psychotherapy has generated considerable deliberation. Methods: The authors debated this subject at the 2004 American Psychiatric Association (APA) meetings. Results: Arguments favoring current requirements emphasize the importance…

  12. Pasteurella multocida from outbreaks of avian cholera in wild and captive birds in Denmark

    DEFF Research Database (Denmark)

    Pedersen, Karl; Dietz, Hans-Henrik; Jørgensen, J.C.;

    2003-01-01

    An outbreak of avian cholera was observed among wild birds in a few localities in Denmark in 2001. The highest mortalities were among breeding ciders (Somateria mollissima) and gulls (Larus spp.). Pulsed-field gel electrophoresis (PFGE) was conducted using ApaI and SmaI as restriction enzymes and...

  13. Redefining the Moral Responsibilities for Food Safety: The Case of Red Meat in New Zealand

    Science.gov (United States)

    Tanaka, Keiko

    2005-01-01

    Food safety governance is shaped by social relationships among the state, the industry, and the public in the food system in a given country. This paper examines the contestation among actors in New Zealand's red meat chain over the implementation of the Animal Product Act of 1999 (APA), which became a cornerstone in the reform of food safety…

  14. UniProt search blastx result: AK287918 [KOME

    Lifescience Database Archive (English)

    Full Text Available dase A) (APA) (Differentiation antigen gp160) (CD249 antigen) - Homo sapiens (Human) 2.00E-16 ... ...AK287918 J065214O12 Q07075|AMPE_HUMAN Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopepti

  15. Addressing the Issue of Fractionation in Autism Spectrum Disorder: A Commentary on Brunsdon and Happé, Frazier et al., Hobson and Mandy et al.

    Science.gov (United States)

    Rutter, Michael

    2014-01-01

    It seems decidedly odd that after more than half a century of both research and clinical experience with autism spectrum disorders (ASDs), there continue to be arguments on the nature of autism. "Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition" ["DSM-5"; American Psychiatric Association (APA), 2013] has not…

  16. Statistical Significance, Effect Size Reporting, and Confidence Intervals: Best Reporting Strategies

    Science.gov (United States)

    Capraro, Robert M.

    2004-01-01

    With great interest the author read the May 2002 editorial in the "Journal for Research in Mathematics Education (JRME)" (King, 2002) regarding changes to the 5th edition of the "Publication Manual of the American Psychological Association" (APA, 2001). Of special note to him, and of great import to the field of mathematics education research, are…

  17. The Role of Statistics and Research Methods in the Academic Success of Psychology Majors: Do Performance and Enrollment Timing Matter?

    Science.gov (United States)

    Freng, Scott; Webber, David; Blatter, Jamin; Wing, Ashley; Scott, Walter D.

    2011-01-01

    Comprehension of statistics and research methods is crucial to understanding psychology as a science (APA, 2007). However, psychology majors sometimes approach methodology courses with derision or anxiety (Onwuegbuzie & Wilson, 2003; Rajecki, Appleby, Williams, Johnson, & Jeschke, 2005); consequently, students may postpone enrollment…

  18. Postural Control in Children: Implications for Pediatric Practice

    Science.gov (United States)

    Westcott, Sarah L.; Burtner, Patricia

    2004-01-01

    Based on a systems theory of motor control, reactive postural control (RPA) and anticipatory postural control (APA) in children are reviewed from several perspectives in order to develop an evidence-based intervention strategy for improving postural control in children with limitations in motor function. Research on development of postural…

  19. 76 FR 72615 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-11-25

    ... ``significant rule '' under DOT Regulatory Policies and Procedures (44 FR 11034; February 26, 1979) ; and (3... obtained from: 1. FAA Public Inquiry Center (APA-200), FAA Headquarters Building, 800 Independence Avenue..., VOR RWY 24, Amdt 8 Murray, KY, Kyle-Oakley Field, GPS RWY 5, Amdt 1 CANCELLED Murray, KY,...

  20. Association of beta2-glycoprotein I IgG and IgM antibodies with thrombosis and thrombocytopenia

    DEFF Research Database (Denmark)

    Voss, Anne-Sofie Boertmann; Jacobsen, Søren; Heegaard, Niels Henrik Helweg

    2001-01-01

    Antiphospholipid antibodies (APA) have been known for decades. Their relation to clinical manifestations, primarily thromboses and thrombocytopenia, was recognised in the 1980s. In this clinical study two cohorts of patients, a population-based (84 patients with systemic lupus erythematosus (SLE)...