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Sample records for ap case study

  1. An Analysis of Media’s Role: Case Study of Army Public School (APS Peshawar Attack

    Directory of Open Access Journals (Sweden)

    Qureshi Rameesha

    2016-12-01

    Full Text Available The study aimed at analyzing the role of media during and after terrorist attacks by examining the media handling of APS Peshawar attack. The sample consisted of males and females selected on convenience basis from universities of Rawalpindi and Islamabad. It was hypothesized that (1 Extensive media coverage of terrorist attacks leads to greater publicity/recognition of terrorist groups (2 Media coverage of APS Peshawar attack increased fear and anxiety in public (3 Positive media handling/coverage of APS Peshawar attack led to public solidarity and peace. The results indicate that i Media coverage of terrorist attacks does help terrorist groups to gain publicity and recognition amongst public ii Media coverage of Aps Peshawar attack did not increase fear/anxiety in fact it directed the Pakistani nation towards public solidarity and peace.

  2. New Wave of Component Reuse with Spring Framework - AP Case Study

    CERN Document Server

    Wozniak, J; Deghaye, S

    2009-01-01

    The myth of component reuse has always been the “holy grail” of software engineering. The motivation var-ies from less time, effort and money expenditure to higher system quality and reliability which is especially impor-tant in the domain of high energy physics and accelerator controls. Identified as an issue by D. McIlroy in 1968 [1], it has been generally addressed in many ways with vari-ous success rates. But only recently with the advent of fresh ideas like the Spring Framework with its powerful yet simple “Inversion of Control” paradigm the solution to the problem has started to be surprisingly uncompli-cated. Gathered over years of experience this document explains best practices and lessons learned applied at CERN for the design of the operational software used to control the accelerator complex and focuses on features of the Spring Framework that render the component reuse achievable in practice. It also provides real life use cases of mission-critical control systems developed by the Ap-plic...

  3. Enablers of Open Source Software adoption: A case study of APS organisations

    Directory of Open Access Journals (Sweden)

    Kavitha Gurusamy

    2012-04-01

    Full Text Available Despite a considerable body of literature investigating factors involved in the Open Source Software (OSS adoption process, there is little research into adoption of OSS by public sector organisations. So it was important to reassess the factors enabling OSS adoption in order to enhance OSS utilization within public sector organisations. This study explored various factors that may enable OSS adoption within Australian Public Sector (APS organisations by interviewing those involved in software procurement. The findings were analysed through the lenses of technology adoption theories (i.e, Diffusion of Innovation (DOI theory and Technology Acceptance Model (TAM, and OSS adoption literature. Success of OSS in government agencies was found to be contingent on critical aspects such as availability of support and maintainability of OSS products, ability to meet organisational business needs in a cost effective manner, economic value associated with OSS such as maintenance and training costs, and attitude of staff toward OSS. The findings suggested that Rogers’ relative advantage and compatibility constructs are major enablers while organisational attributes, environmental attributes, and TAM’s attributes also had some influence on OSS adoption.

  4. STUDY OF ORGANOPHOSPHOROUS POISONING CASES AT MAHARAJAH INSTITUTE OF MEDICAL SCIENCES, A.P.

    Directory of Open Access Journals (Sweden)

    Aswini Kumar

    2014-08-01

    Full Text Available BACKGROUND & OBJECTIVES: Organophosphorus pesticide self-poisoning is a major clinical and public-health problem across much of rural Asia. The aim of this study was to analyze the patterns, the social factors and the clinical outcomes of OP poisoning at the Maharajah Institute Of Medical Sciences, Vizianagaram. MATERIALS AND METHODS: Fifty organophosphorous poisoning cases who were admitted to the MIMS, during the period of 1year (May 2013to June 2014, were studied. RESULTS: Fifty cases of OP poisoning were studied. In the present study, 56% cases were males, with the highest number of cases in the age group of 21 to 30 years (44%. Sixty four % belonged to married category. Sixty % of organophosphorous poisoning victims belonged to the farming community. Chlorpyrifos was consumed by 58% of the victims. 64 % of the OP poisoning victims were having family problems. Muscarinic and nicotinic symptoms were prevalent in majority of victims. 64 % people had recovery and Intermediate syndrome was observed in 36% cases of organophosphorous poisoning. CONCLUSION: There was a high incidence of OP poisoning related mortality in this region. The OP compounds were readily available at low costs in the market. A time of stress and frustration can lead to their use as a common poison to commit suicide with.

  5. Social media activism and Egyptians' use of social media to combat sexual violence: an HiAP case study.

    Science.gov (United States)

    Peuchaud, Sheila

    2014-06-01

    This paper represents a case study of how social media activists have harnessed the power of Facebook, Twitter and mobile phone networks to address sexual harassment in Egypt. HarassMap plots reports of sexual harassment on a Google Map and informs victims of support services. Tahrir Bodyguard and Operation Anti-Sexual Harassment (OpAntiSH) protect female protestors who have been vulnerable to sexual aggression at the hands of unruly mobs and by agents of the state. Activists have access to an Android app called 'I'm Getting Arrested' or 'Byt2ebed 3alia' in Egyptian Arabic. The app sends the time and GPS coordinates of an arrest to family, fellow activists, legal counsel and social media outlets. The hope is the initiatives described in this paper could inspire public health ministries and activist NGOs to incorporate crowdsourcing social media applications in the spirit of health in all policies (HiAP). To that end, this paper will begin by defining social media activism from the perspective of the communications discipline. This paper will then demonstrate the significance of sexual harassment as a public health issue, and describe several social media efforts to document incidents and protect victims. The paper will conclude with discussion regarding how these innovations could be integrated into the HiAP approach.

  6. GeoDCAT-AP: Use cases and open issues

    OpenAIRE

    PEREGO ANDREA; FRIIS-CHRISTENSEN Anders; Lutz, Michael

    2016-01-01

    This paper illustrates some issues and use cases identified during the design and implementation of GeoDCAT-AP, a metadata profile aiming to provide a representation of geospatial metadata compliant with the DCAT application profile for European data portals (DCAT-AP). In particular, the paper focuses on those issues that may have a possible relevance also outside the geospatial domain, covering topics concerning metadata profile-based negotiation, publishing metadata on the Web, represen...

  7. Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

    Directory of Open Access Journals (Sweden)

    Almind Katrine

    2008-12-01

    Full Text Available Abstract Background Several studies in multiple ethnicities have reported linkage to type 2 diabetes on chromosome 1q21-25. Both PKLR encoding the liver pyruvate kinase and NOS1AP encoding the nitric oxide synthase 1 (neuronal adaptor protein (CAPON are positioned within this chromosomal region and are thus positional candidates for the observed linkage peak. The C-allele of PKLR rs3020781 and the T-allele of NOS1AP rs7538490 are reported to strongly associate with type 2 diabetes in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR of 1.33 [1.16–1.54] and 1.53 [1.28–1.81], respectively. Our aim was to validate these findings by investigating the impact of the two variants on type 2 diabetes and related quantitative metabolic phenotypes in a large study sample of Danes. Further, we intended to expand the analyses by examining the effect of the variants in relation to overweight and obesity. Methods PKLR rs3020781 and NOS1AP rs7538490 were genotyped, using TaqMan allelic discrimination, in a combined study sample comprising a total of 16,801 and 16,913 individuals, respectively. The participants were ascertained from four different study groups; the population-based Inter99 cohort (nPKLR = 5,962, nNOS1AP = 6,008, a type 2 diabetic patient group (nPKLR = 1,873, nNOS1AP = 1,874 from Steno Diabetes Center, a population-based study sample (nPKLR = 599, nNOS1AP = 596 from Steno Diabetes Center and the ADDITION Denmark screening study cohort (nPKLR = 8,367, nNOS1AP = 8,435. Results In case-control studies we evaluated the potential association between rs3020781 and rs7538490 and type 2 diabetes and obesity. No significant associations were observed for type 2 diabetes (rs3020781: pAF = 0.49, OR = 1.02 [0.96–1.10]; rs7538490: pAF = 0.84, OR = 0.99 [0.93–1.06]. Neither did we show association with overweight or obesity. Additionally, the PKLR and the NOS1AP genotypes were demonstrated not

  8. [Serum enzyme alterations during diabetic ketoacidosis. Prospective study of the behaviour of AP, AsAT, AIAT, and GGPT in 24 cases (author's transl)].

    Science.gov (United States)

    Pérez-Jiménez, F; Muñoz, R; Jiménez Perepérez, J; Jiménez Alonso, J; Grilo, A; Benito, P

    1981-09-25

    Because of the scarcity of data on the changes of serum enzymes during diabetic ketoacidosis, the authors have prospectively studied the alterations of gamma-glutamyl transpeptidase (GGTP), alkaline phosphatase (AP), aspartate aminotransferase (AsAT), and alanine aminotransferase (AIAT) in this metabolic disturbance. The most significant finding was the frequent increase of AP activity on admission, with a systematic fall of the serum levels within the first 24 hours (p less than 0.001). This phenomenon was negatively correlated with patients' age (p less than 0.05), and the same occurred with the bone isoenzyme of AP (p less than 0.01). The remaining enzymes studies were always normal, thus suggesting that any increase of the serum levels of GGTP, AsAT, and AIAT found in a patient with diabetic ketoacidosis must arise the suspicion of an associated disturbance.

  9. AP1000进度管理研究%The study on AP1000 Schedule management

    Institute of Scientific and Technical Information of China (English)

    李阳; 王飞鸣

    2015-01-01

    核电建设进度管理非常重要,本文针对核电站进度管理的内容、体系、管理方式等进行介绍,并结合AP1000核电技术的特点——模块化,分析其对进度管理的影响和目前存在的问题。并结合影响和问题提出了在后续AP1000建设进度管理中的几项建议。%Nuclear power plant construction progress management is very important. This paper addresses important topics including the content, system and manage methods of nuclear power plants construction. Combining the characteristics of AP1000 nuclear power technology-modular, the paper analyzed its impact on progress management and the existing problems. Depending on the impacts and problems, the paper also raised several suggestions in AP1000 modular construction.

  10. Cistoadenoma mucinoso do apêndice: relato de caso Mucinous cystadenoma of the appendix: case report

    Directory of Open Access Journals (Sweden)

    Cristiano Feijó Andrade

    2001-12-01

    Full Text Available O cistoadenoma mucinoso do apêndice ceca l, um tipo de mucocele do apêndice, é uma neoplasia benigna caracterizada pela metaplasia focal ou difusa do epitélio superficial da mucosa, associada à dilatação do apêndice e produção de muco para a luz apendicular. No presente estudo os autores relatam um caso de cistoadenoma mucinoso do apêndice observado em uma mulher de 65 anos de idade, com dor e massa palpável no quadrante inferior direito do abdome, cujo quadro teve início há 1 ano. O diagnóstico de cistoadenoma do apêndice foi suspeitado através da ultrassonografia e tomografia computadorizada do abdome, e confirmado pelo exame histopatológico. A paciente também apresentava cálculos na vesícula biliar e um cisto renal à direita. A laparotomia foi indicada sendo realizada a apendicectomia, a colecistectomia e a exérese do cisto renal. Na presente discussão esperamos contribuir para o diagnóstico precoce dessa doença e a melhor compreensão de sua classificação e patogenia.Mucinous cystadenoma of the vermiform appendix, a type of mucocele of appendix, is a benign neoplasm characterized by focal or diffuse metaplasia of the superficial epithelium of mucosae, associated with appendix dilation and mucinous secretion into the appendiceal lumen. At present study the authors report a case of mucinous cystadenoma of appendix observed in a 65-yr-old woman with pain and palpated mass in the right lower quadrant of the abdomen started one year ago. Cystadenoma of the appendix was suspected throughout ultrasonography and CT scan of abdomen and confirmed by histology. Pacient also presented gallstones, and a right renal cyst. Laparotomy was indicated, appendicectomy and cholecystectomy performed and, renal cyst removed. At present issue we hope to contribute for early detection of this disease, and better understanding of its classification and pathogenesis.

  11. The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey

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    Midilli Kenan

    2009-06-01

    Full Text Available Abstract Background Crimean-Congo Hemorrhagic Fever (CCHF is a fatal infection, but no clinical case due to AP92 strain was reported. We described the first clinical case due to AP92 like CCHFV. Methods A case infected by a AP92 like CCHFV was detected in Balkanian part of Turkey. Diagnosis was confirmed by RT-PCR and sequencing. A human serologic and tick survey studies were performed in the region, where the case detected. Results Thirty eight individuals out of 741 were found to be anti CCHFV IgM positive. The attack rate for overall CCHFV was calculated as 5.2%. In univariate analyses, CCHFV IgM positivity was found to be associated with the age (p Conclusion This is the first human case with AP92 like CCHFV infection. Furthermore, this is the first report of AP92 like strain in Turkey. In the region, elderly males carry the highest risk for CCHFV infection.

  12. The first clinical case due to AP92 like strain of Crimean-Congo Hemorrhagic Fever virus and a field survey

    Science.gov (United States)

    2009-01-01

    Background Crimean-Congo Hemorrhagic Fever (CCHF) is a fatal infection, but no clinical case due to AP92 strain was reported. We described the first clinical case due to AP92 like CCHFV. Methods A case infected by a AP92 like CCHFV was detected in Balkanian part of Turkey. Diagnosis was confirmed by RT-PCR and sequencing. A human serologic and tick survey studies were performed in the region, where the case detected. Results Thirty eight individuals out of 741 were found to be anti CCHFV IgM positive. The attack rate for overall CCHFV was calculated as 5.2%. In univariate analyses, CCHFV IgM positivity was found to be associated with the age (p < 0.001), male gender (p = 0.001), agricultural activity (p = 0.036), and history of tick bite (p = 0.014). In multivariate analysis, older age (OR: 1.03, CI:1.01–1.05, p < 0.001), male gender were found to be the risk factors (OR: 2.5, CI:1.15–5.63, p = 0.020) for CCHFV infection. Conclusion This is the first human case with AP92 like CCHFV infection. Furthermore, this is the first report of AP92 like strain in Turkey. In the region, elderly males carry the highest risk for CCHFV infection. PMID:19515251

  13. AP/二茂铁衍生物混合体系的热感度研究%Study on thermal sensitivity of AP and ferrocene derivative mixtures

    Institute of Scientific and Technical Information of China (English)

    王宁; 赵孝彬; 罗岚; 李彦荣; 段卫毅

    2011-01-01

    通过局部热感度试验和DSC-TG联用仪,研究了高氯酸铵(AP)和一种二茂铁衍生物(EMT)混合体系的热感度.结果表明,减小AP粒度或增加EMT含量,能缩小AP高低温分解峰之间的差距,提高AP低温分解量,混合物的局部热感度增加.AP存在下,EMT的侧链容易发生断裂,断裂后的二茂铁或二茂铁离子活性体对AP分解起催化作用.此外,EMT 不利于AP的质子转移过程,但对HClO4的分解有较强催化作用.%Thermal sensitivity of AP and ferrocene derivative (EMT) mixtures was studied by partial thermal sensitivity and DSC-TG coupling. The results indicate that reducing AP particle size or increasing the content of EMT can shorten the gap between high-temperature thermal decomposition peak of AP and low-temperature thermal decomposition peak of AP, enhance the low-temperature thermad decomposition amount of AP,and increase partial thermal sensitivity about mixtures of AP and EMT. In the presence of AP, side-chain of EMT is easily ruptured. Residual main skeleton, ferrocene or ferrocene ion, is the real catalyst to thermal decomposition of AP. Furthermore, EMT inhabits proton transfer process of AP, but it is a strong catalysis of EMT to decomposition of HCIO4, one of initial decomposition product of AP.

  14. Psychosocial intervention, as a contribution to local human development within Medellin’s public scope. Case study: project aps - “buenvivir” (good living into a family. sponsor: City hall of Medellin, Colombia

    Directory of Open Access Journals (Sweden)

    J. J. García

    2013-10-01

    Full Text Available This article provides information about a research held on the psychosocial intervention offered from social projects such as educational formative spaces. A critical analysis is made by means of a government project conducted by the local administration of the city of Medellin known as “APS Buenvivir en Familia, 2011”, compiled by the Social Welfare Town Council Office, in association with the Municipality’s Health Department. Its purpose was to examine the logic and approach of psychosocial intervention as an input to human development. It was carried out through a qualitative focusing, taking in consideration the following categories: The psychosocial intervention has a definite impact on local human development, psychosocial praxis from the point of view of a public action strategy, community involvement taken as a true political act. The results showed that the psychosocial as a public exercise makes a contribution to local human development starting from the social involvement of communities and, in its everyday doing, presents structural and formal contradictions between the way they are designed and how the projects are planned and implemented among the people. 

  15. Preliminary study to AP mine neutralisation by EFP impact

    NARCIS (Netherlands)

    Meulman, J.H.

    2004-01-01

    A preliminary study has been conducted into the response of anti-personnel mines at the impact of an Explosively Formed Projectile (EFP). The objective was to obtain a low order reaction (preferably a deflagration) to minimise collateral damage. Further the method should be capable to neutralise min

  16. Search of X-ray emission from roAp stars: The case of gamma Equulei

    CERN Document Server

    Stelzer, B; Schöller, M; Hubrig, S; Cowley, C

    2011-01-01

    The detection of X-ray emission from Ap stars can be an indicator for the presence of magnetic activity and dynamo action, provided different origins for the emission, such as wind shocks and close late-type companions, can be excluded. Here we report on results for gamma Equu, the only roAp star for which an X-ray detection is reported in ROSAT catalogs. We use high resolution imaging in X-rays with Chandra and in the near-infrared with NACO/VLT that allow us to spatially resolve companions down to ~1" and ~0.06" separations, respectively. The bulk of the X-ray emission is associated with a companion of gamma Equu identified in our NACO image. Assuming coevality with the primary roAp star (~900 Myr), the available photometry for the companion points at a K-type star with ~0.6 M_sun. Its X-ray properties are in agreement with the predictions for its age and mass. An excess of photons with respect to the expected background and contribution from the nearby companion is observed near the optical position of gam...

  17. Spinal cord injury: epidemiologycal study of 386 cases with emphasis on those patients admitted more than four hours after the trauma Trauma raquimedular: estudo epidemiológico de 386 casos com ênfase para aqueles pacientes admitidos após quatro horas do trauma

    Directory of Open Access Journals (Sweden)

    Manoel Baldoino Leal-Filho

    2008-06-01

    Full Text Available We studied 386 cases of spinal cord injury to analyze the follow up of the patients admitted most of the time more than four hours, the majority of the injuries happening far from the attending health service and first specialized care received long after the accident. This is a clinical study based on data collected during hospitalization of the patients, operated or not, in a Brazilian public health service. The lesion mainly seen was fracture and dislocation, isolated or on multiple levels, and the most important clinical complications were due to respiratory failure and hypotension, especially because 73.8% were from outside and they were admitted more then four hours after the trauma. The mortality rate was 11.9%, but just 2.1% had undergone a surgery. The complications resulted in major risk of death when the trauma was at the cervical level and the patients were over 50 years old, especially when admitted more than four hours after the trauma. We emphasize the importance of the first health care concerning the clinical treatment, aiming to reduce the mortality rate.Estudamos 386 casos de trauma raquimedular, observando a evolução dos pacientes admitidos na maioria das vezes após quatro horas do trauma, a maioria procedente de lugar distante do serviço de saúde. Trata-se de um estudo clínico baseado em dados coletados durante a hospitalização, de pacientes operados ou não, em serviço de saúde pública no Brasil. Na maioria das vezes a lesão principal foi fratura-luxação, isolada ou em múltiplos níveis, e as complicações clínicas mais importantes foram devido à insuficiência respiratória e hipotensão, especialmente porque 73.8% dos casos eram de lugares distantes, tendo sido admitidos mais de quatro horas após o trauma. A taxa de mortalidade foi 11,9%, sendo 2,1% em pós-operatório. As complicações resultaram em maior risco de morte quando o trauma foi ao nível cervical, idade acima de 50 anos, especialmente

  18. Conformational characteristics of dimeric subunits of RNA from energy minimization studies. Mixed sugar-puckered ApG, ApU, CpG, and CpU.

    Science.gov (United States)

    Thiyagarajan, P; Ponnuswamy, P K

    1981-09-01

    Following the procedure described in the preceding article, the low energy conformations located for the four dimeric subunits of RNA, ApG, ApU, CpG, and CpU are presented. The A-RNA type and Watson-Crick type helical conformations and a number of different kinds of loop promoting ones were identified as low energy in all the units. The 3E-3E and 3E-2E pucker sequences are found to be more or less equally preferred; the 2E-2E sequence is occasionally preferred, while the 2E-3E is highly prohibited in all the units. A conformation similar to the one observed in the drug-dinucleoside monophosphate complex crystals becomes a low energy case only for the CpG unit. The low energy conformations obtained for the four model units were used to assess the stability of the conformational states of the dinucleotide segments in the four crystal models of the tRNAPhe molecule. Information on the occurrence of the less preferred sugar-pucker sequences in the various loop regions in the tRNAPhe molecule has been obtained. A detailed comparison of the conformational characteristics of DNA and RNA subunits at the dimeric level is presented on the basis of the results.

  19. Case Study: Testing with Case Studies

    Science.gov (United States)

    Herreid, Clyde Freeman

    2015-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses using case studies to test for knowledge or lessons learned.

  20. A Missing-Link in the Supernova-GRB Connection: The Case of SN 2012ap

    CERN Document Server

    Chakraborti, Sayan; Chomiuk, Laura; Kamble, Atish; Yadav, Naveen; Ray, Alak; Hurley, Kevin; Margutti, Raffaella; Milisavljevic, Dan; Bietenholz, Michael; Brunthaler, Andreas; Pignata, Giuliano; Pian, Elena; Mazzali, Paolo; Fransson, Claes; Bartel, Norbert; Hamuy, Mario; Levesque, Emily; MacFadyen, Andrew; Dittmann, Jason; Krauss, Miriam; Briggs, M S; Connaughton, V; Yamaoka, K; Takahashi, T; Ohno, M; Fukazawa, Y; Tashiro, M; Terada, Y; Murakami, T; Goldsten, J; Barthelmy, S; Gehrels, N; Cummings, J; Krimm, H; Palmer, D; Golenetskii, S; Aptekar, R; Frederiks, D; Svinkin, D; Cline, T; Mitrofanov, I G; Golovin, D; Litvak, M L; Sanin, A B; Boynton, W; Fellows, C; Harshman, K; Enos, H; von Kienlin, A; Rau, A; Zhang, X; Savchenko, V

    2014-01-01

    Gamma Ray Bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly usually within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However supernovae, with heavy ejecta, can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. Yet the ejecta from SN 2009bb was baryon loaded, and in nearly-free expansion for a year, unlike GRBs. We report the first supernova discovered without a GRB, but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. This shows that central engines in type Ic supernovae, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.

  1. Case study

    DEFF Research Database (Denmark)

    Milana, Marcella; Bernt Sørensen, Tore

    of several DHSs. Furthermore ?Udspil? was chosen for being a non-formal learning activity based on individual participation, even though linked to institutionalized learning practices, which were carried out in cooperation between several local institutions.Last but not least, the project represents...... that time Roskilde University Centre and Learning Lab Denmark, DK)3. The case here presented is based on results from research activity carried out over a 1 year period (spring 2006 - spring 2007). Detailed information concerning participation in the project was collected in two DHSs only: the Sports Day......Learning for democratic citizenship is embedded in the general popular education ideal(folkeoplysning), which is the primary source of inspiration for the Day High Schools (DHSs). DHSs are private institutions supported by local authorities, that host primarily low educated and unemployed young...

  2. A genomic and expression study of AP-1 in primary cutaneous T-cell lymphoma: evidence for dysregulated expression of JUNB and JUND in MF and SS.

    Science.gov (United States)

    Mao, Xin; Orchard, Guy; Mitchell, Tracey J; Oyama, Noritaka; Russell-Jones, Robin; Vermeer, Maarten H; Willemze, Rein; van Doorn, Remko; Tensen, Cornelis P; Young, Bryan D; Whittaker, Sean J

    2008-10-01

    Activator protein 1 (AP-1) consists of a group of transcription factors including the JUN and FOS family proteins with diverse biological functions. This study assessed the genomic and expression status of the AP-1 transcription factors in primary cutaneous T-cell lymphoma (CTCL) by using immunohistochemistry (IHC), Affymetrix expression microarray, real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescent in situ hybridization (FISH). IHC showed JUNB protein expression in tumor cells from 17 of 33 cases of Sezary syndrome (SS) and JUND protein expression in 16 of 23 mycosis fungoides cases. There was no correlation between JUNB and CD30 expression. However, 7 of 12 JUNB-positive SS cases expressed both phosphorylated and total extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated protein kinase (MAPK) proteins. Expression microarray showed over threefold increased expression of JUNB in three of six SS patients and similar findings were also noted after re-analysis of previously published data. Real-time RT-PCR confirmed the overexpression of JUNB in four SS cases and of JUND in three of four cases. FISH showed increased JUNB copy number in four of seven SS cases. These findings suggest that deregulation of AP-1 expression in CTCL is the result of aberrant expression of JUNB and possible JUND resulting from genomic amplification and constitutive activation of ERK1/2 MAPK in this type of lymphoma.

  3. A MISSING-LINK IN THE SUPERNOVA–GRB CONNECTION: THE CASE OF SN 2012ap

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborti, Sayan; Soderberg, Alicia; Kamble, Atish; Margutti, Raffaella; Milisavljevic, Dan; Dittmann, Jason [Institute for Theory and Computation, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Chomiuk, Laura [Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States); Yadav, Naveen; Ray, Alak [Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Mumbai 400005 (India); Hurley, Kevin [Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720 (United States); Bietenholz, Michael [Department of Physics and Astronomy, York University, 4700 Keele St., M3J 1P3 Ontario (Canada); Brunthaler, Andreas [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Pignata, Giuliano [Departamento de Ciencias Fisicas, Universidad Andres Bello, Avda. Republica 252, Santiago (Chile); Pian, Elena [Scuola Normale Superiore, Piazza Dei Cavalieri 7—I-56126 Pisa (Italy); Mazzali, Paolo [Liverpool John Moores University, IC2, 146 Brownlow Hill, Liverpool (United Kingdom); Fransson, Claes [Department of Astronomy, Stockholm University, AlbaNova, SE-106 91 Stockholm (Sweden); Bartel, Norbert [Hartebeesthoek Radio Astronomy Observatory, PO Box 443, Krugersdrop, 1740 (South Africa); Hamuy, Mario [Departamento de Astronoma, Universidad de Chile (Chile); Levesque, Emily [University of Colorado, C327A, Boulder, CO 80309 (United States); MacFadyen, Andrew, E-mail: schakraborti@fas.harvard.edu [New York University, 4 Washington Place, New York, NY 10003 (United States); and others

    2015-06-01

    Gamma-ray bursts (GRBs) are characterized by ultra-relativistic outflows, while supernovae are generally characterized by non-relativistic ejecta. GRB afterglows decelerate rapidly, usually within days, because their low-mass ejecta rapidly sweep up a comparatively larger mass of circumstellar material. However, supernovae with heavy ejecta can be in nearly free expansion for centuries. Supernovae were thought to have non-relativistic outflows except for a few relativistic ones accompanied by GRBs. This clear division was blurred by SN 2009bb, the first supernova with a relativistic outflow without an observed GRB. However, the ejecta from SN 2009bb was baryon loaded and in nearly free expansion for a year, unlike GRBs. We report the first supernova discovered without a GRB but with rapidly decelerating mildly relativistic ejecta, SN 2012ap. We discovered a bright and rapidly evolving radio counterpart driven by the circumstellar interaction of the relativistic ejecta. However, we did not find any coincident GRB with an isotropic fluence of more than one-sixth of the fluence from GRB 980425. This shows for the first time that central engines in SNe Ic, even without an observed GRB, can produce both relativistic and rapidly decelerating outflows like GRBs.

  4. Pneumomediastino espontâneo após esforço vocal: relato de caso Spontaneous pneumomediastinum following vocal effort: a case report

    Directory of Open Access Journals (Sweden)

    Flávia Paiva Lobo Lopes

    2010-04-01

    Full Text Available Neste estudo é relatado o caso de um paciente do sexo masculino, 14 anos de idade, que após fazer grande esforço vocal, durante uma partida de futebol, desenvolveu quadro agudo de dor torácica. As radiografias de tórax e a tomografia computadorizada evidenciaram pneumomediastino, com pequeno pneumotórax bilateral. Os exames clínico, laboratoriais e radiológicos não demonstraram qualquer fator predisponente, ficando o caso classificado como pneumomediastino espontâneo.The present article reports the case of a 14-year-old male patient who developed acute chest pain following increased vocal effort during a soccer game. Chest radiography and computed tomography demonstrated pneudomediastinum with small bilateral pneumothorax. Clinical, laboratory and radiological studies did not demonstrate any predisposing factor, and the case was classified as spontaneous pneudomediastinum.

  5. Case Study: Writing a Journal Case Study

    Science.gov (United States)

    Prud'homme-Genereux, Annie

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue describes incorporating a journal article into the classroom by first converting it into a case study.

  6. Study on the thermal decomposition behavior of RDX/AP/HTPB propellant%RDX/AP/HTPB推进剂热分解特性研究

    Institute of Scientific and Technical Information of China (English)

    陈沛; 赵凤起; 阴翠梅

    2002-01-01

    利用高压差示扫描量热仪(PDSC)研究了RDX/AP/HTPB推进剂系列配方的热分解性能,发现配方组分的改变对RDX/AP/HTPB推进剂的热分解性能有影响,突出表现在RDX/AP/HTPB推进剂中RDX分解峰变宽,AP放热分解效应增强.推进剂中添加Al粉后,RDX的分解受到抑制,而AP的分解却得到增强.

  7. AP statistics crash course

    CERN Document Server

    D'Alessio, Michael

    2012-01-01

    AP Statistics Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP Statistics Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP Statistics course description outline and actual Advanced Placement test questions. It covers only the information tested on the exam, so you can make the most of your valuable study time. Our easy-to-read format covers: exploring da

  8. A Comparative Study On The Action Potential Simulation (APS Therapy And The Routine Physiotherapy Protocol In Knee Osteoarthritisin Elderly People

    Directory of Open Access Journals (Sweden)

    Abbas Rahimi

    2012-04-01

    Full Text Available Background and Aim: Knee osteoarthritis is the most common cause for which the elderly people refere to physiotherapy outpatient clinics. This study aimed to investigate the effects of the Action Potential Stimulation (APS Therapy and the routine physiotherapy (PT protocol on relieving pain and swelling as well as the duration of the relief period in patients with knee osteoarthritis. Materials and Methods: 69 patients (62 females & 7 males with knee osteoarthritis were recruited in this study. The subjects were divided into two groups including APS Therapy (n=37, mean age: 55±13 years old and the routine PT protocol (n=32, mean age: 61±14 years old groups. A 10-session treatment period was carried out for each group; and their pain and swelling were measured at the first, fifth and tenth sessions and also one-month after the last session (follow up. The swelling was measured using measuring the circumference of the knee on the patella, 5 Cm above and 5 Cm below the patella. The routine PT protocol consisted of hot pack, ultrasound, TENS and exercise; and the APS therapy protocol included hot pack, APS Therapy and the same exercise. During the follow up, 50 out of 61 subjects were called on the phone and any pain changes were recorded.Results: In terms of swelling, the results showed significant reduction just on the patella only in the APS Therapy group (P<0.05. Visual Analogue Pain Scale (VAPS indicated a significant pain reduction in both groups. However, the APS Therapy group showed significantly pain reduction at the end of sessions five, ten and the follow up session (P<0.05. It was also revealed that while routine PT subjects showed no significant pain changes between the tenth and the follow up session, a gradual pain reduction was seen in the APS therapy group during this period (P<0.05. A gradual dosage reduction was recorded only in the APS therapy group, indicating a slight correlation with pain reduction (r=0.4.Conclusion: The

  9. Case Study Teaching

    Science.gov (United States)

    Herreid, Clyde Freeman

    2011-01-01

    This chapter describes the history of case study teaching, types of cases, and experimental data supporting their effectiveness. It also describes a model for comparing the efficacy of the various case study methods. (Contains 1 figure.)

  10. 基于案例的随堂考核法在应用技术课程的实践--以“工程CAD基础”课程教学为例%Practice of Case -oriented Classroom Assessment Ap-proach in Applied Technique Courses:A Case Study on the Course of "Introduction to Engineering CAD"

    Institute of Scientific and Technical Information of China (English)

    李长冬; 吴琼; 李德营

    2015-01-01

    The applied technique courses are the necessary skill training courses for the engineering undergraduates, and they are of great importance for their future career. Illustrated by the course of "Introduction to Engineering CAD", the engineering case teaching approach, including the interest promoting, skill training and case analysis stages, was put into effect to motivate the studying interest and the practical ability of undergraduates. Furthermore, the case-oriented classroom assessment approach was proposed, including the phased intensive training and class-room site assessment and summarization, which can enhance the interactive teaching and encourage the undergraduates to grasp the CAD manipulative skill quickly.%应用技术课程是工科大学生必要的技能训练课程,对其今后工作实践具有重要意义。以“工程CAD基础”课程为例,采用工程案例教学法,分为兴趣提升、技能培养和实例分析三个阶段进行教学,既激发了学生学习兴趣,又加强了其动手操作能力。同时,提出了基于案例教学的随堂考核法,设计了分阶段强化拓展训练,并及时进行随堂考核与总结,加强了师生间教学互动,促进学生尽快掌握工程CAD操作技能。

  11. Feasibibility study - cases

    DEFF Research Database (Denmark)

    Lund, Henrik; Hvelplund, Frede Kloster; Sukkumnoed, Decharut

    2004-01-01

    The chapter presents two case studies to show the tools of feasibiliy studies within the context of technological innovation.......The chapter presents two case studies to show the tools of feasibiliy studies within the context of technological innovation....

  12. Project management case studies

    CERN Document Server

    Kerzner, Harold R

    2013-01-01

    A new edition of the most popular book of project management case studies, expanded to include more than 100 cases plus a ""super case"" on the Iridium Project Case studies are an important part of project management education and training. This Fourth Edition of Harold Kerzner''s Project Management Case Studies features a number of new cases covering value measurement in project management. Also included is the well-received ""super case,"" which covers all aspects of project management and may be used as a capstone for a course. This new edition:Contains 100-plus case studies drawn from re

  13. Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (I): catastrophic APS, APS nephropathy and heart valve lesions.

    Science.gov (United States)

    Cervera, R; Tektonidou, M G; Espinosa, G; Cabral, A R; González, E B; Erkan, D; Vadya, S; Adrogué, H E; Solomon, M; Zandman-Goddard, G; Shoenfeld, Y

    2011-02-01

    The objectives of the 'Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations' were to assess the clinical utility of the international consensus statement on classification criteria and treatment guidelines for the catastrophic APS, to identify and grade the studies that analyse the relationship between the antiphospholipid antibodies and the non-criteria APS manifestations and to present the current evidence regarding the accuracy of these non-criteria APS manifestations for the detection of patients with APS. This article summarizes the studies analysed on the catastrophic APS, APS nephropathy and heart valve lesions, and presents the recommendations elaborated by the Task Force after this analysis.

  14. Boildown Study on Supernatant Liquid Retrieved from AP-107 in May 2010

    Energy Technology Data Exchange (ETDEWEB)

    Callaway, W. S. [Washington River Protection Solutions, LLC, Richland, WA (United States); Page, J. S. [Washington River Protection Solutions, LLC, Richland, WA (United States)

    2013-02-12

    A boildown study was completed on a composite prepared from supernatant liquid grab samples retrieved from tank 241-AP-107 in May of 2010. The composite was a clear, yellow liquid containing no visible solids at hot cell ambient temperatures (25-27 °C). The density of the test composite was 1.216 g/mL at 26.8 °C. The boiling temperature curves generated at three reduced pressures—40-, 60-, and 80 Torr—displayed steadily increasing boiling temperatures with increasing volume reduction with no significant discontinuities. Only minimal foaming was observed after the volume reduction proceeded beyond 50 %WVR (percent waste volume reduction). The bulk densities (D{sub Bulk}{sup 18 °C}) and quantities of settled and centrifuged solids present were measured on samples of the boildown concentrates that were kept at 18 °C for 7-8 days. Estimated values of the bulk densities of the concentrates at 60-Torr boiling temperatures (D{sub Bulk}{sup 60 Torr}) were also calculated. Solids were observed in all boildown concentrates at process temperatures, at hot cell ambient temperatures (25-27 °C), and at 18 °C. The quantity of solids found in the cooled concentrates increased slowly through 50.2 %WVR. The quantity of solids found in concentrates after 54.0 %WVR was noticeably greater. Beyond 54.0 %WVR, the quantity of solids found in cooled concentrates increased dramatically. Analysis of boildown test samples indicated that sodium oxalate and sodium carbonate solids form in cooled concentrates after volume reduction of 8.4 %WVR or less. The major contributors to the large increase in the quantity of solids found in concentrates after 54 %WVR were sodium nitrate and sodium carbonate.

  15. Study on Mitigation Strategy of AP1000 Spent Fuel Pool Exterior Disaster%AP1000外部灾害情形下乏燃料池缓解策略研究

    Institute of Scientific and Technical Information of China (English)

    徐红

    2012-01-01

    日本福岛核事故后,乏燃料池(SFP)在事故中的安全性得到广泛的关注.AP1000乏燃料池冷却系统(SFS)是一非安全相关的系统,不需在事故后运行以缓解设计基准事故.但乏燃料池在超设计基准事故或外部灾害事件(包括自然灾害和人为事件)下的安全性一直是核电厂设计的重点.本工作结合美国核能研究所(NEI)给出的扩大损害的缓解导则(EDMG)提出了针对AP1000外部灾害情形下的SFP缓解策略(包括内部策略和外部策略),并对策略进行了评估.本工作结论有助于AP1000 SFP EDMG的建立,对AP1000核电厂的设计、建造、运行管理和事故管理均有很强的参考价值.%After Fukushima nuclear accident, much attention has been paid to the safety of the spent fuel pool (SFP). AP1000 spent fuel pool cooling system (SPS) is not a safety related system. It is not designed for design basis accident. But the safety of SFP in exterior disaster and severe accident is very important. The extensive damage mitigation guidelines (EDMG) of NEI to AP1000 SFP accident mitigation was studied, including internal strategy and external strategy. The results are useful for design AP1000 nuclear power plant and the mitigation when SFP exterior disaster happens.

  16. APS Science 2009.

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, J. M; Mills, D. M.; Gerig, R.

    2010-05-01

    ), the challenge of sustainable energy provides an opportunity for expanded involvement with industrial research. We were privileged to recruit several outstanding new leaders at the APS. Linda Young, from Argonne's Chemical Sciences Division, became the new Director of the X-ray Science Division (XSD). Chris Jacobsen (from Stony Brook University) has been added to Linda's team as an XSD Associate Division Director, joining George Srajer. Alexander (Sasha) Zholents (formerly of Berkeley Lab) became Director of the Accelerator Systems Division. Sasha is the inventor of the short-pulse x-ray scheme that we plan to implement in the APS-U to obtain very high average brightness, broadband, 1-ps x-ray pulses. Walter Lowe (formerly of Howard University) has taken a new position as senior advisor for outreach and development of the user community. Walter's role is to increase the diversity of the user community (with diversity read broadly to include users, institutions, and technical disciplines that are underrepresented at APS). Walter is also leading an effort to increase access for industrial users. I am confident that we have in place a great team to help our users and the APS take fullest advantage of the APS-U opportunity. In planning with users for the proposed APS-U, we focused on the need to study 'real materials under real conditions in real time' on spatial and temporal scales unavailable today. Only by studying materials as they are made-or as they perform-in difficult environments can we solve the grand challenge of higher-performance, sustainable materials for energy and health. The proposed APS-U will improve the brightness of penetrating x-rays produced by the APS over 100 times, and support our efforts in developing state-of-the-art instruments to address these challenges.

  17. Study on the faint star extraction technology with MEMS gyro aided APS star tracker

    Science.gov (United States)

    Xing, Fei; Zhao, Borui; Sun, Ting; Xu, Wei; You, Zheng

    2013-08-01

    Star tracker is the most accurate attitude sensor for satellite. Generally speaking, the higher the accuracy, the fainter the star can be sensed by the star tracker. How to extract the faint star from a star image is becoming a critical technology in dynamic condition for star tracker, especially using the APS (Active Pixels Sensor) detector. A novel APS star tracker with MEMS Gyroscope aided system was proposed in this paper that could extremely improve the detection effect and capability for the faint stars. During the exposure time of star tracker, the trajectory of star projection on the detector maybe occupy more than ten pixels due to the satellite rotation. In this situation, the signal-to-noise ratio will decline sharply, and the traditional star extraction method for faint star will take no effect. As a result, the accuracy of star tracker would decline sharply, even more, couldn't work. Using the MEMS Gyroscope, the track of star projection can be predicated and measured, on the basis of which the deconvolution algorithm could be taken to recover the faint star signal. The accuracy of the star projection centroid could be improved obviously, and the dynamic performance of the star tracker would be improved by a magnitude. Meanwhile, the MEMS gyroscope has not less volume, mass and power consumption, which make it more suitable for the application of APS star tracker.

  18. Case study research.

    Science.gov (United States)

    Taylor, Ruth; Thomas-Gregory, Annette

    2015-06-10

    This article describes case study research for nursing and healthcare practice. Case study research offers the researcher an approach by which a phenomenon can be investigated from multiple perspectives within a bounded context, allowing the researcher to provide a 'thick' description of the phenomenon. Although case study research is a flexible approach for the investigation of complex nursing and healthcare issues, it has methodological challenges, often associated with the multiple methods used in individual studies. These are explored through examples of case study research carried out in practice and education settings. An overview of what constitutes 'good' case study research is proposed.

  19. An analysis of AP600 design features

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Kyoon; Jang, Moon Heui; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)] [and others

    1994-01-01

    In the aspect of engineering, passive safety system concept has improved the safety degree of nuclear power plant. Therefore, the objective of this study is to check on the possibility of the capacity upgrade of nuclear power plant in the case of adopting the passive safety system concept of AP 600. The characteristics of AP 600 are the advanced functions in ECCS, heat removal of containment building and residual heat removal under the passive safety system concept. The result of this study will become the basic data of capacity upgrade of nuclear power plant and will be widely used in second year project. (Author).

  20. AP physics B crash course

    CERN Document Server

    Howell, Rebecca

    2012-01-01

    AP Physics B Crash Course - Get a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. Our AP Physics B Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know The Crash Course is based on an in-depth analysis of the AP Physics B course description outline and actual AP test questions. It covers only the information tested on the exam, so you can make the most of your valuable study time. Our easy-to-read format covers: mechanics, kinetic theory, t

  1. Abscessos cerebrais múltiplos após apendicectomia: relato de caso Multiple brain abscesses following appendicectomy: case report

    Directory of Open Access Journals (Sweden)

    Michele Schops

    1996-06-01

    Full Text Available Paciente masculino de 39 anos, com quadro de abdomen agudo de evolução de 72 horas, foi submetido a apendicectomia. Desenvolveu 14 dias após, quadro de cefaléia, vômitos, afasia, torpor, hemiplegia à direita e rigidez de nuca. A tomografia computadorizada craniana mostrou múltiplos abscessos cerebrais supra tentoriais bilateralmente. Após punção aspirativa do maior deles foi instituída antibióticoterapia resultando em cura do paciente.A 39 years old male patient with a 72 hours evolution of acute abdominal syndrome was submitted to appendicectomy. Fourteen days later he developed headache, vomiting, aphasia, torpor, nuchal stiffness and right hemiplegia. A CT-scan showed multiple brain abscesses on both hemispheres. After aspirative puncture of the largest one, antibiotic treatment was established with total recovery of the patient.

  2. AP1000核电机组模块化建造技术的研究%The Study on Modularization Construction of AP1000 Nuclear Power Plant

    Institute of Scientific and Technical Information of China (English)

    郑宝忠; 颜岩; 孙汉虹

    2015-01-01

    本文对AP1000核电机组模块及模块化定义和分类进行介绍的基础上,讨论了模块化建造的实施,包括模块化设计、模块预制、模块运输、模块组装、模块吊装和模块安装等,提出了模块化在缩短建造周期、提高工程质量和降低工程造价方面的优势,分析模块化应用带来的挑战,提出具体的应对措施.

  3. Evolução do comportamento auditivo após meningite bacteriana: relato de caso Auditory behaviour monitoring after bacterial meningitis: case report

    Directory of Open Access Journals (Sweden)

    Ida Lichtig

    1997-06-01

    Full Text Available A deficiência auditiva adquirida tem nas meningites bacterianas a sua principal etiologia e pouco tem-se dito a respeito da evolução para melhora ou piora do comportamento auditivo após a alta hospitalar. O presente estudo descreve o caso de um menino que teve meningite por Haemophilus influenzae aos 5 meses de vida e que entre outras complicações apresentou diminuição da acuidade auditiva detectada na evolução imediata, com melhora significativa posteriormente, confirmada por testes qualitativos e quantitativos. Discute-se a importância e a necessidade do seguimento fonoaudiológico de tais indivíduos para estabelecer orientação adequada.Bacterial meningitis is the main cause for acquired hearing loss. Nevertheless very little has been written about the development of the auditory behaviour either for improvement or for deterioration, after hospital release. The present study describes the case of a five month old boy with Haemophilus influenzae meningitis. Amongst various complications, a decrement in the auditory acuity was detected in the immediate evolution, with significant improvement later on by qualitative and quantitative tests.

  4. RELATIVISTIC SUPERNOVAE HAVE SHORTER-LIVED CENTRAL ENGINES OR MORE EXTENDED PROGENITORS: THE CASE OF SN 2012ap

    Energy Technology Data Exchange (ETDEWEB)

    Margutti, R.; Milisavljevic, D.; Soderberg, A. M.; Sanders, N.; Chakraborti, S.; Kamble, A.; Drout, M.; Parrent, J.; Zauderer, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Guidorzi, C. [Department of Physics and Earth Sciences, University of Ferrara, via Saragat 1, I-44122 Ferrara (Italy); Morsony, B. J. [Department of Astronomy, University of Wisconsin-Madison, 2535 Sterling Hall, 475 North Charter Street, Madison, WI 53706-1582 (United States); Ray, A. [Department of Astronomy and Astrophysics, Tata Institute of Fundamental Research, 1 Homi Bhabha Road, Mumbai 400 005 (India); Chomiuk, L. [Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824 (United States)

    2014-12-20

    Deep, late-time X-ray observations of the relativistic, engine-driven, type Ic SN 2012ap allow us to probe the nearby environment of the explosion and reveal the unique properties of relativistic supernova explosions (SNe). We find that on a local scale of ∼0.01 pc the environment was shaped directly by the evolution of the progenitor star with a pre-explosion mass-loss rate of M-dot <5×10{sup −6} M{sub ⊙} yr{sup −1}, in line with gamma-ray bursts (GRBs) and the other relativistic SN 2009bb. Like sub-energetic GRBs, SN 2012ap is characterized by a bright radio emission and evidence for mildly relativistic ejecta. However, its late-time (δt ≈ 20 days) X-ray emission is ∼100 times fainter than the faintest sub-energetic GRB at the same epoch, with no evidence for late-time central engine activity. These results support theoretical proposals that link relativistic SNe like 2009bb and 2012ap with the weakest observed engine-driven explosions, where the jet barely fails to break out. Furthermore, our observations demonstrate that the difference between relativistic SNe and sub-energetic GRBs is intrinsic and not due to line-of-sight effects. This phenomenology can either be due to an intrinsically shorter-lived engine or to a more extended progenitor in relativistic SNe.

  5. A STUDY OF RISK FACTORS IN STROKE PATIENTS IN GOVT., GENERAL HOSPITAL, KURNOOL, A.P

    Directory of Open Access Journals (Sweden)

    B.S. Isaac

    2013-10-01

    Full Text Available ABSTRACT : A study was undertaken on 50 patients admitted in Govt. General Hospital, Kurnool with acute cerebrovascular disease by using a pretested questionnaire. Parameters studied were age, sex, blood pressure, diabetes mellitus, smoking, alcohol, and hypercholesterolemia. 30(60% patients gave the history of hypertension in the past and were on treatment, apart from 10 more pa tients recorded a high blood pressure (>140/90 at the time of admission, making a total of 40(80% patients with hypertension. Out of 40 cases of hypertension, 30(75% had cerebral infarction and 10(25% had cerebral hemorrhage. 18 patients gave the hist ory of diabetes, and 14 more had blood sugar more than 140 mgs% at the time of admission, making a total of 32(64%. Out of 30 cases of diabetes, 20(66% had infarction and 10(33% had hemorrhage. 25 (50% patients were in the habit of smoking at a frequen cy of 5 - 25 cigarettes per day. Out of 25 patients with smoking 20(80% had infarction and 5(20% had hemorrhage. 16 patients gave the history of alcoholism. Out of which 7(43.7% had infarction and 9(56.3% had hemorrhage. Out of the 25 patients with smok ing habit 16 were hypertensive patients and 9 patients revealed raised serum cholesterol. Out of 16 patients with alcohol habit, 11 were hypertensive patients and 5 had raised serum cholesterol. Out of these 11 hypertensive patients 5 had infarction and 6 had hemorrhage. The 5 patients who had raised cholesterol 3 had infarction and 2 had hemorrhage. Out of the 32 diabetes cases, 21 had hypertension, and 11 had raised serum cholesterol. Out of 21 hypertensive’s, 12 had infarction and 9 had hemorrhage. Out o f 11 patients who had raised serum cholesterol, 8 had infarction and 3 had hemorrhage

  6. CLINICAL STUDY ON PA NCREATIC CANCER IN G OVERNMENT GENERAL HOSPITAL, GU NTUR, AP, INDIA

    Directory of Open Access Journals (Sweden)

    Ch. Kalyan

    2015-03-01

    Full Text Available Pancreatic cancer has a lower incidence than many other types of cancer, but is the fourth most common cause of death from cancer, among men and women, being responsible for 6% of all cancer - related deaths. The global annual incidence rate for pancreas cancer is about 8/100,000 persons. Pancreatic cancer disease is notoriously difficult to diagnose in its early stages. Study was carried out in the Department of General Surgery, Government General Hospital, Guntur from October 2010 to 2012, in which 16 cases with a diagnosis of carcinoma pancreas. They were investigated with routine blood investigations. They were treated accordingly with Pylorus preserving pancreaticodenectomy (PPPD or palliative bypass or with non - operative palliative measures. Carcinoma pancreas is an aggressive disease with male preponderance with peak incidence in 5th and 6th decade. Important risk factors are Smoking and alcohol consumption. Nearly 75% of the cases presented in the late stage of the disease. Resection of the tumour had better survival. The limitations of our study are small number of patients and short follow - up

  7. Relação entre a lesão condral e o pico de torque após reconstrução do ligamento cruzado anterior do joelho: estudo de casos Relationship between chondral lesion and peak torque following anterior cruciate ligament reconstruction of the knee: case study

    Directory of Open Access Journals (Sweden)

    RF Traete

    2007-06-01

    Full Text Available CONTEXTUALIZAÇÃO: A associação entre lesão do ligamento cruzado anterior (LCA e desenvolvimento de osteoartrite (OA secundária tem sido objeto de vários estudos. A lesão ligamentar predispõe a lesões da cartilagem articular, influenciando, assim, o controle motor e o pico de torque. OBJETIVO: Avaliar a influência do grau de lesão condral no pico de torque da musculatura anterior e posterior da coxa após lesão e reconstrução do LCA. MÉTODO: Seis sujeitos do sexo masculino com lesão total e unilateral do LCA foram avaliados pré-cirurgia (24 horas antes da cirurgia e pós-cirurgia em dois momentos distintos, 4,66 ± 1,03 e 15,83 ± 2,63 meses, respectivamente. As avaliações isocinéticas foram realizadas no modo concêntrico de flexão e extensão do joelho, nas velocidades de 60º/s e 180º/s, em que foram a analisadas as variáveis PT dos isquiotibiais (PTI, PT do quadríceps (PTQ e a relação entre eles (I/Q. A escala histológica de Mankin modificada foi utilizada para avaliar o grau macroscópico de lesão condral. O teste estatístico ANOVA (pCONTEXT: The association between anterior cruciate ligament (ACL injury and the development of secondary osteoarthritis has been the subject of several studies. Ligament injury predisposes joint cartilage lesions, thus influencing motor control and peak torque. OBJECTIVE: To evaluate the influence of the degree of chondral lesion on peak torque of the anterior and posterior musculature of the thigh following ACL injury and reconstruction. METHOD: Six male subjects with total unilateral ACL injury were evaluated 24 hours before surgery and at two times after surgery (4.66 ± 1.03 and 15.83 ± 2.63 months, respectively. Isokinetic evaluations of knee flexion and extension were made in concentric mode, at velocities of 60º/s and 180º/s, and the variables of hamstring peak torque (HPT and quadriceps peak torque (QPT and hamstring/quadriceps ratio (H/Q were analyzed. The modified

  8. APS Science 2007.

    Energy Technology Data Exchange (ETDEWEB)

    2008-05-30

    This report provides research highlights from the Advanced Photon Source (APS). Although these highlights represent less than 10% of the published work from the APS in 2007, they give a flavor of the diversity and impact of user research at the facility. In the strategic planning the aim is to foster the growth of existing user communities and foresee new areas of research. This coming year finds the APS engaged in putting together, along with the users, a blueprint for the next five years, and making the case for a set of prioritized investments in beamlines, the accelerator, and infrastructure, each of which will be transformational in terms of scientific impact. As this is written plans are being formulated for an important user workshop on October 20-21, 2008, to prioritize strategic plans. The fruit from past investments can be seen in this report. Examples include the creation of a dedicated beamline for x-ray photon correlation spectroscopy at Sector 8, the evolution of dedicated high-energy x-ray scattering beamlines at sectors 1 and 11, a dedicated imaging beamline at Sector 32, and new beamlines for inelastic scattering and powder diffraction. A single-pulse facility has been built in collaboration with Sector 14 (BioCARS) and Phil Anfinrud at the National Institutes of Health, which will offer exceptionally high flux for single-pulse diffraction. The nanoprobe at Sector 26, built and operated jointly by the Argonne Center for Nanoscale Materials and the X-ray Operations and Research (XOR) section of the APS X-ray Science Division, has come on line to define the state of the art in nanoscience.

  9. Comparison of exposure dose by using AEC mode of abdomen AP study in radiography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ki Won [Dept. of Radiology, Gang-dong Kyung Hee Medical Center, Seoul (Korea, Republic of); Kwon, Yong Rak; Seo, Seong Won [Dept. of Radiology, Samsung Medical Center, Seoul (Korea, Republic of); Kwon, Kyung Tae [Dept. of Radiology, Dongnam Health University, Suwon (Korea, Republic of); Oh, Joo Young; Son, Soon Yong [Asan Medical Center, Seoul (Korea, Republic of); Min, Jung Whan [Dept. of Radiology, Shingu University, Sungnam (Korea, Republic of)

    2015-09-15

    We evaluated the effectiveness of TL (Time Limit) method by comparing with NTL (Non-time limit) method when it is used for examinations for abdomen Anterior Posterior (AP) in this paper. The evaluation was conducted based on the comparison of dose, and of signal to noise ratio (SNR) and contrast to ratio (CNR) on both methods. The experiments were conducted with XGEO GC 80 (Samsung, Korea), Unfors ThinX RAD (Unfors, Sweden) and Rando Phantom (Alderson research laboratories, USA) and shielding material with the size of 5.5 × 9 × 0.1 cm{sup 3}. It was set to activate only two upper ionization chambers in automatic exposure control (AEC) mode and the tube-voltage was set to 80kVp. When the exposure time was limited, it is limited to 51 msec. The images both by NTL AEC method and TL AEC method were acquired when with and without attachment of shielding material on the upper ionization chambers. The images were evaluated by SNR and CNR which are the image evaluation methods using ‘Image J’. The NTL AEC method showed increases in dose as much as 130.7% at maximum and 80% at minimum than other methods. The TL AEC method showed decreases in mAs and exposure dose than the NTL AEC method as much as 43.8% and 44.4% respectively. There were no significant differences in SNR or CNR for the experiments (p≥0.05). Therefore, it is suggested that the TLAEC mode is more effective when examining patients who have high BMI index or a patient with a metallic substance in the body after surgery.

  10. Objectivist case study research

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner; Fachner, Jörg

    2016-01-01

    be achieved through the use of objectivist case study research. The strength of the case study design is that it allows for uncovering or suggesting causal relationships in real-life settings through an intensive and rich collection of data. According to Hilliard (1993), the opposite applies for extensive...... designs, in which a small amount of data is gathered on a large number of subjects. With the richness of data, the intensive design is ―the primary pragmatic reason for engaging in single-case or small N research‖ (p. 374) and for working from an idiographic rather than a nomothetic perspective....

  11. AP statistics

    CERN Document Server

    Levine-Wissing, Robin

    2012-01-01

    All Access for the AP® Statistics Exam Book + Web + Mobile Everything you need to prepare for the Advanced Placement® exam, in a study system built around you! There are many different ways to prepare for an Advanced Placement® exam. What's best for you depends on how much time you have to study and how comfortable you are with the subject matter. To score your highest, you need a system that can be customized to fit you: your schedule, your learning style, and your current level of knowledge. This book, and the online tools that come with it, will help you personalize your AP® Statistics prep

  12. A Comparative Study on Ni-Based Coatings Prepared by HVAF, HVOF, and APS Methods for Corrosion Protection Applications

    Science.gov (United States)

    Sadeghimeresht, E.; Markocsan, N.; Nylén, P.

    2016-12-01

    Selection of the thermal spray process is the most important step toward a proper coating solution for a given application as important coating characteristics such as adhesion and microstructure are highly dependent on it. In the present work, a process-microstructure-properties-performance correlation study was performed in order to figure out the main characteristics and corrosion performance of the coatings produced by different thermal spray techniques such as high-velocity air fuel (HVAF), high-velocity oxy fuel (HVOF), and atmospheric plasma spraying (APS). Previously optimized HVOF and APS process parameters were used to deposit Ni, NiCr, and NiAl coatings and compare with HVAF-sprayed coatings with randomly selected process parameters. As the HVAF process presented the best coating characteristics and corrosion behavior, few process parameters such as feed rate and standoff distance (SoD) were investigated to systematically optimize the HVAF coatings in terms of low porosity and high corrosion resistance. The Ni and NiAl coatings with lower porosity and better corrosion behavior were obtained at an average SoD of 300 mm and feed rate of 150 g/min. The NiCr coating sprayed at a SoD of 250 mm and feed rate of 75 g/min showed the highest corrosion resistance among all investigated samples.

  13. Relação entre a lesão condral e o pico de torque após reconstrução do ligamento cruzado anterior do joelho: estudo de casos Relationship between chondral lesion and peak torque following anterior cruciate ligament reconstruction of the knee: case study

    OpenAIRE

    2007-01-01

    CONTEXTUALIZAÇÃO: A associação entre lesão do ligamento cruzado anterior (LCA) e desenvolvimento de osteoartrite (OA) secundária tem sido objeto de vários estudos. A lesão ligamentar predispõe a lesões da cartilagem articular, influenciando, assim, o controle motor e o pico de torque. OBJETIVO: Avaliar a influência do grau de lesão condral no pico de torque da musculatura anterior e posterior da coxa após lesão e reconstrução do LCA. MÉTODO: Seis sujeitos do sexo masculino com lesão total e u...

  14. Asymmetric pulmonary edema after scorpion sting: a case report Edema pulmonar assimétrico após picada de escorpião: relato de caso

    Directory of Open Access Journals (Sweden)

    Ebrahim Razi

    2008-12-01

    Full Text Available A 12-year-old boy was referred with acute asymmetric pulmonary edema (APE four-hour after scorpion sting to Emergency department. On admission, the main clinical manifestations were: dyspnea, tachypnea, and tachycardia. Chest x-ray revealed APE predominantly on the right hemithorax. The patient was treated with oxygen, intravenous frusemide and digoxin and discharged on the sixth hospital day in a good condition. This case report emphasizes the occurrence of asymmetric pulmonary edema after severe scorpion envenomation within few hours immediately after the sting.Menino de 12 anos foi internado no Pronto Socorro, com edema pulmonar assimétrico agudo (APE, quatro horas após picada de escorpião. À admissão, as principais manifestações clínicas foram: dispnéa, taquipnéa e taquicardia. Raio X do pulmão revelou APE predominantemente no hemitórax direito. O paciente foi tratado com oxigênio, frusemida intravenosa e digoxina e teve alta no sexto dia de internação, em boas condições. Este relato de caso enfatiza a ocorrência de edema pulmonar assimétrico algumas horas após a picada.

  15. Hypothyroidism following struma ovarii tumor resection: a case report Hipotireoidismo após ressecção de tumor struma ovarii: relato de caso

    Directory of Open Access Journals (Sweden)

    Jesus Paula Carvalho

    2002-06-01

    Full Text Available Struma ovarii is an infrequent ovarian tumor, and there are only few reports with detailed data of thyroid function. In several cases, malignant struma ovarii have been shown to produce hyperthyroidism, but there is no reported case of hypothyroidism following struma ovarii tumor resection. A 62-year-old white woman underwent right ovary resection that had a pathologic diagnosis of struma ovarii. After 6 days, she developed weakness, myalgia, somnolence, nausea, and arterial hypotension. Laboratory tests showed a high level of thyroid-stimulating hormone (TSH and a decreased level thyroxin. Thyroxin replacement therapy was initiated, and the patient became completely asymptomatic. This is the first reported case of a previously asymptomatic woman who developed a definite clinical hypothyroidism after resection of a struma ovarii tumor.Struma ovarii é um tumor infreqüente com poucos relatos de casos abordando detalhadamente a função tireoidiana. Na maioria dos casos têm sido demonstrado que o struma ovarii produz hipertireoidismo, entretando não existe relatos de desenvolvimento de hipotireoidismo após a retirada deste tumor. Uma mulher branca de 62 anos foi submetida a oforectomia direita com diagnóstico anatomopatológico de struma ovarii. Após seis dias da cirurgia, a paciente desenvolveu fraqueza, mialgia, sonolência, náusea e hipotensão arterial. Exames laboratoriais demonstraram níveis elevados de hormônio tireo-estimulante (TSH e baixos de T3 e T4. Foi iniciado terapia de reposição de tiroxina e a paciente recuperou seus parâmetros clínicos e laboratoriais. Não existe, até o momento, relato de hipotireoidismo seguindo a exerese de struma ovarii. Este é o primeiro caso de uma mulher com função tireoidiana prévia normal que desenvolveu hipotireoidismo clínico após a ressecção de um tumor ovariano struma ovarii.

  16. Case Studies in Biology.

    Science.gov (United States)

    Zeakes, Samuel J.

    1989-01-01

    A case study writing exercise used in a course on parasitology was found to be a powerful learning experience for students because it involved discipline-based technical writing and terminology, brought the students in as evaluators, applied current learning, caused interaction among all students, and simulated real professional activities. (MSE)

  17. AP Music Theory Applied

    Science.gov (United States)

    Spieker, Matthew H.

    2016-01-01

    Some American high schools include Advanced Placement (AP) Music Theory within their course offerings. Students who pass the AP exam can receive college credit either as a music or humanities credit. An AP class, however, offers music students more than future college credit; it ultimately improves musicianship skills and promotes deeper…

  18. SU-E-T-14: A Feasibility Study of Using Modified AP Proton Beam for Post-Operative Pancreatic Cancer Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Ding, X; Witztum, A; Kenton, O; Younan, F; Dormer, J; Kremmel, E; Lin, H; Liu, H; Tang, S; Both, S; Kassaee, A; Avery, S [UniversityPennsylvania, Philadelphia, PA (United States)

    2014-06-01

    Purpose: Due to the unpredictability of bowel gas movement, the PA beam direction is always favored for robust proton therapy in post-operative pancreatic cancer treatment. We investigate the feasibility of replacing PA beam with a modified AP beam to take the bowel gas uncertainty into account. Methods: Nine post-operative pancreatic cancer patients treated with proton therapy (5040cGy, 28 fractions) in our institution were randomly selected. The original plan uses PA and lateral direction passive-scattering proton beams. Beam weighting is about 1:1. All patients received weekly verification CTs to assess the daily variations(total 17 verification CTs). The PA direction beam was replaced by two other groups of AP direction beam. Group AP: takes 3.5% range uncertainty into account. Group APmod: compensates the bowel gas uncertainty by expanding the proximal margin to 2cm more. The 2cm margin was acquired from the average bowel diameter in from 100 adult abdominal CT scans near pancreatic region (+/- 5cm superiorly and inferiorly). Dose Volume Histograms(DVHs) of the verification CTs were acquired for robustness study. Results: Without the lateral beam, Group APmod is as robust as Group PA. In Group AP, more than 10% of iCTV D98/D95 were reduced by 4–8%. LT kidney and Liver dose robustness are not affected by the AP/PA beam direction. There is 10% of chance that RT kidney and cord will be hit by AP proton beam due to the bowel gas. Compared to Group PA, APmod plan reduced the dose to kidneys and cord max significantly, while there is no statistical significant increase in bowel mean dose. Conclusion: APmod proton beam for the target coverage could be as robust as the PA direction without sacrificing too much of bowel dose. When the AP direction beam has to be selected, a 2cm proximal margin should be considered.

  19. Piomiosite em atletas após o uso de esteroides anabolizantes: relato de casos Pyomyositis in athletes after the use of anabolic steroids: case reports

    Directory of Open Access Journals (Sweden)

    Nivaldo Souza Cardozo Filho

    2011-01-01

    Full Text Available Relato da conduta de cinco casos de piomiosite em atletas após o uso de esteroides anabolizantes. Nos últimos 10 anos foram avaliados cinco atendimentos a atletas no Centro de Traumatologia do Esporte (CETE - EPM - Unifesp que desenvolveram piomiosite após o uso de esteroides anabolizantes. Todos os pacientes foram diagnosticados clínica e laboratorialmente e por exames de imagem, sendo realizado tratamento cirúrgico (com coleta de material para cultura e antibioticoterapia. Em quatro casos, os locais de administração foram nos membros superiores e, em um dos casos, nos glúteos bilaterais, além dos membros superiores. Nos cinco casos, houve a ocorrência de leucocitose com neutrofilia no hemograma e, após a limpeza cirúrgica, os germes habituais da pele (S. aureus e S. viridans foram encontrados na cultura das secreções. A delimitação do abscesso, assim como o estudo do plano muscular em que se encontrava, foi realizada por meio do estudo de imagem com ultrassonografia e ressonância magnética. Todos responderam à antibioticoterapia de amplo espectro e, em dois casos, foi necessário mais de um procedimento cirúrgico devido ao surgimento de mais de um ponto de abscesso com tempo de evolução diferente. O uso de esteroides anabolizantes por alguns atletas pode trazer consequências graves; a intervenção rápida, enérgica e multidisciplinar se faz necessária nesses casos para se evitar resultados não desejáveis. O tratamento adequado curou os atletas completamente, com retorno ao esporte no mesmo nível.OBJECTIVE: To report on the management of five cases of pyomyositis in athletes after the use of anabolic steroids. METHOD: Over the past 10 years, five cases of athletes who developed pyomyositis after using anabolic steroids were attended at the Sports Trauma Center (CETE, EPM-UNIFESP. RESULTS: All the patients were diagnosed clinically and through laboratory and imaging tests. Surgical treatment was carried out (with

  20. Case Studies - Cervical Cancer

    Centers for Disease Control (CDC) Podcasts

    2010-10-15

    Dr. Alan Waxman, a professor of obstetrics and gynecology at the University of New Mexico and chair of the American College of Obstetricians and Gynecologists (ACOG) committee for the underserved, talks about several case studies for cervical cancer screening and management.  Created: 10/15/2010 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP), Division of Cancer Prevention and Control (DCPC).   Date Released: 6/9/2010.

  1. Plant-specific insertions in the soybean aspartic proteinases, soyAP1 and soyAP2, perform different functions of vacuolar targeting.

    Science.gov (United States)

    Terauchi, Kaede; Asakura, Tomiko; Ueda, Haruko; Tamura, Tomoko; Tamura, Kentaro; Matsumoto, Ichiro; Misaka, Takumi; Hara-Nishimura, Ikuko; Abe, Keiko

    2006-07-01

    Most aspartic proteinases (APs) of plant origin are characterized by the presence of plant-specific insertion (PSI) in their primary structure. PSI has been reported to function as signals for both transport of AP molecules from the endoplasmic reticulum (ER) and for their targeting to the vacuole. To determine the functions of the PSIs in soyAP1 and soyAP2 identified in our previous study, we examined their subcellular localization by transient expression of a green fluorescent protein (GFP) fusion protein in the protoplasts of Arabidopsis suspension-cultured cells. Both soyAP1-GFP and soyAP2-GFP were targeted to the vacuole. To confirm the role of the PSI, we prepared PSI-deleted soyAP1 and soyAP2, and investigated their vacuolar targeting by the same method. While the former deletion mutant was always transported to the vacuole, the latter sometimes remained in the ER and was only sometimes transported to the vacuole. These observations indicated that, in the case of soyAP1, the PSI is not involved in vacuolar targeting, also suggesting that the function of the PSI differs depending on its origin.

  2. Hypersexuality following bilateral thalamic infarction: case report Hiperssexualidade após infarto talâmico bilateral: relato de caso

    Directory of Open Access Journals (Sweden)

    Eduardo G. Mutarelli

    2006-03-01

    Full Text Available Hypersexuality is a rare but well recognized condition following brain injury. It has been described secondarily to dysfunction in the hypothalamus, the temporal and frontal lobes. We report a 63 year-old man that developed neuropsychological disturbances with hypersexuality as a prominent feature, disinhibition and moderate memory loss, hypersomnia and irritability after a bilateral paramedian thalamic infarction. A SPECT showed frontal hypoperfusion. We believe that these findings are expression of frontal-subcortical circuits dysfunction, particularly the orbitofrontal circuit, secondary to dorso medial thalamic infarction which probably plays a role in the determination of human sexual behavior. This case favors a thalamic modulation of frontal function.Hiperssexualidade é uma condição rara mas bem reconhecida após lesão do sistema nervoso central. A literatura medica registra casos secundários a disfunção do hipotálamo, do lobo temporal e do lobo frontal. Relatamos o caso de um homem de 63 anos de idade que desenvolveu alterações neuropsicológicas com hiperssexualidade como característica mais proeminente, desinibição, moderada perda de memória, hipersonia e irritabilidade após infarto talâmico paramediano bilateral. O SPECT evidenciou hipoperfusão frontal. Nós acreditamos que esses achados sejam expressão da disfunção de circuitos córtico-subcorticais frontais, particularmente do circuito órbito-frontal, secundária ao infarto dorsomedial do tálamo, que provavelmente desempenha papel relevante na determinação do comportamento sexual humano. Este caso favorece uma possível função moduladora do tálamo sobre os circuitos córtico-subcorticais frontais.

  3. Case Study - Alpha

    Directory of Open Access Journals (Sweden)

    Stephen Leybourne

    2016-11-01

    Full Text Available This case study was developed from an actual scenario by Dr. Steve Leybourne of Boston University.  The case documents the historical evolution of an organization, and has been used successfully in courses dealing with organizational and cultural change, and the utilization of ‘soft skills’ in project-based management. This is a short case, ideal for classroom use and discussion.  The issues are easily accessible to students, and there is a single wide ranging question that allows for the inclusion of many issues surrounding strategic decision-making, and behavioural and cultural change. Alpha was one of the earlier companies in the USA to invest in large, edge-of-town superstores, with plentiful free vehicle parking, selling food and related household products. Alpha was created in the 1950s as a subsidiary of a major publicly quoted retail group.  It started business by opening a string of very large discount stores in converted industrial and warehouse premises in the south of the United States. In the early days shoppers were offered a limited range of very competitively priced products. When Alpha went public in 1981 it was the fourth largest food retailer in the US, selling an ever-widening range of food and non-food products.  Its success continued to be based on high volume, low margins and good value for money, under the slogan of ‘Alpha Price.’

  4. A neurogenic tumor containing a low-grade malignant peripheral nerve sheath tumor (MPNST) component with loss of p16 expression and homozygous deletion of CDKN2A/p16: a case report showing progression from a neurofibroma to a high-grade MPNST.

    Science.gov (United States)

    Tajima, Shogo; Koda, Kenji

    2015-01-01

    Development of malignant peripheral nerve sheath tumors (MPNSTs) is a stepwise process that involves the alteration of many cell cycle regulators and the double inactivation of the NF1 gene. Inactivation of the TP53 gene and deletion of the CDKN2A/p16 gene are known to play an important role in the process. Herein, we present a 19-year-old man with a familial history of neurofibromatosis type 1, in whom the tumor arose from the intercostal nerve and showed 3 components: a neurofibroma, a low-grade MPNST, and a high-grade MPNST. Loss of p16 expression and homozygous deletion of the CDKN2A/p16 gene were observed in both the low-grade and the high-grade MPNST. In contrast to low-grade MPNSTs, high-grade MPNSTs generally tend to lose expression of p16 and harbor homozygous deletion of the CDKN2A/p16 gene. Loss of p16 expression and homozygous deletion of the CDKN2A/p16 gene in low-grade MPNST in our case might be related to its progression to high-grade MPNST. To the best of our knowledge, this is the first study correlating the p16 expression status and CDKN2A/p16 gene alteration in low-grade MPNSTs.

  5. Ceratite por Staphylococcus aureus após ceratomileuse in situ por laser (LASIK: relato de caso Staphylococcus aureus keratitis following laser in situ keratomileusis: case report

    Directory of Open Access Journals (Sweden)

    Alessandra Pinheiro Chaves

    2000-04-01

    Full Text Available Objetivo: Relatar um caso clínico de infecção por S. aureus no pós- operatório de LASIK, o tratamento adotado e a evolução clínica. Relato do caso: Paciente de 26 anos, masculino, submetido a LASIK tórico em OE, evoluindo com ceratite por S. aureus. Após diagnóstico clínico da infecção, realizamos estudo microbiológico e foi instituída a terapêutica adequada. O paciente evoluiu com recuperação da transparência corneana e acuidade visual 20/25, sem correção. Discussão: Infecção no pós-operatório de LASIK, quando diagnosticada precocemente e tratada adequadamente, pode evoluir sem maiores complicações e sem comprometimento visual significativo.Purpose: To report a case of S. aureus keratitis after laser in situ keratomileusis, the management and the outcome. Case report: 26-year-old male underwent toric LASIK OS, evoluing with S. aureus keratitis. After a clinical hypothesis of infection, we performed corneal scrape for lab analysis and proper treatment was given. After successful treatment, the patient showed an improvement in corneal transparency and recovered his visual acuity. Discussion: Infections following laser in situ keratomileusis may not produce visual loss if proper treatment is given.

  6. Parto prematuro após uso de antimonial pentavalente: relato de um caso Premature birth after the use of pentavalent antimonial: case report

    Directory of Open Access Journals (Sweden)

    Bruna Pinheiro Silveira

    2003-07-01

    Full Text Available Relata-se o caso de uma mulher de 19 anos, na 24ª semana de gravidez e com leishmaniose visceral. Tratada com antimonial pentavalente na posologia de 850mg/dia por 20 dias, ocorreu parto prematuro no quinto dia de tratamento e óbito da criança um dia após nascimento. Considerando a importância da protozoose no nosso meio e a raridade da associação com a gestação, julgamos de interesse a publicação do caso.A case is reported of a 19-year-old woman, at week 24 of gestation, with visceral leishmaniosis. She was treated with meglumine antimoniate at a dose of 850mg/day for 20 days. There occurred premature birth on day five of treatment and the neonate died one day after birth. Considering the importance of protozoiasis in our population and the rarity of the association with pregnancy, we resolved to publish the case.

  7. Importance of the multi-modules study in PSA; Importancia del estudio de multi-modulos en APS

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez R, V. J.; Nelson E, P. F., E-mail: judith_gonzalez_rodriguez@outlook.es [UNAM, Facultad de Ingenieria, Departamento de Sistemas Energeticos, Paseo Cuauhnahuac 8532, 62550 Jiutepec, Morelos (Mexico)

    2015-09-15

    The current approach that has taken the Probabilistic Safety Analysis (PSA) consists of doing all the APS analysis including the existence of multi-units in the nuclear power plants (NPP), this new approach seeks to analyze the risk of site, evaluating all reactors together. The main reasons for this trend are: the accident occurred on March 2011 in Fukushima Daiichi in Japan, with serious consequences in more than one reactor of the NPP and the current planning and construction of new Small Modular Reactors, which host more than one module on the same NPP and are connected to a single control room. This study analyzes how to model the risk of a multi-module NPP. In 2013, the ASME/ANS standard for advanced reactors that are not light-water reactors was published, in which the requirements to realize a PSA including multi-units or modules are shown; however, does not describe the methodology to do that. This article presents a methodology to calculate the risk of the site in a PBMR plant with two modules. This methodology consists of two models of trees of different events, one that evaluates to a single PBMR module and another that evaluates the two modules together. Both models are responsible to show their differences and compare results to finally demonstrate the need for new methodologies for risk analysis site in multi-modules and units. (Author)

  8. Prolapso de tuba uterina após histerectomia vaginal: relato de caso Fallopian tube prolapse after vaginal hysterectomy: a case report

    Directory of Open Access Journals (Sweden)

    Maurício B. Noviello

    2003-12-01

    Full Text Available O prolapso de tuba uterina é complicação rara após histerectomia, com aproximadamente 80 casos descritos na literatura. A sintomatologia é inespecífica, podendo incluir sangramento genital, dispareunia e dor pélvica crônica. O diagnóstico diferencial deve ser feito com granuloma de cúpula vaginal e carcinoma de vagina. O tratamento deve ser individualizado, podendo ser realizado por via vaginal, abdominal ou laparoscópica. Relatamos o caso de uma paciente, 47 anos, com miomatose uterina, submetida a histerectomia vaginal, evoluindo com prolapso de tuba uterina após 11 meses de pós-operatório. O exame especular evidenciava lesão vegetante, friável e sangrante localizada na cúpula vaginal. Esses achados clínicos sugeriam o diagnóstico de prolapso de tuba uterina. A paciente foi submetida a nova intervenção cirúrgica, com ressecção da tuba uterina por via vaginal. O exame natomopatológico confirmou o diagnóstico e a paciente evoluiu com remissão completa da sintomatologia.Fallopian tube prolapse is a rare complication after hysterectomy, with approximately 80 cases described in the literature. The symptoms are nonspecific including vaginal bleeding, dyspareunia and chronic pelvic pain. The differential diagnosis must be done with granulation tissue of the vaginal cuff and vaginal carcinoma. The treatment should be individualized, and is possible to be done by vaginal, abdominal or laparoscopic approach. We report a case of a 47-year-old woman with myoma who was submitted to a vaginal hysterectomy and evolved with fallopian tube prolapse 11 months after surgery. Specular examination showed a fungating, friable and bleeding lesion at the vaginal cuff. The clinical findings suggested the diagnosis of fallopian tube prolapse. The patient was submitted to a new surgical intervention with resection of the left fallopian tube. The histologic examination confirmed the diagnosis and the patient evolved with complete remission of

  9. Advanced Photon Source (APS)

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Photon Source (APS) at the U.S. Department of Energy's Argonne National Laboratoryprovides this nation's (in fact, this hemisphere's) brightest storage...

  10. Study of impact of the AP1000{sup Registered-Sign} reactor vessel upper internals design on fuel performance

    Energy Technology Data Exchange (ETDEWEB)

    Xu Yiban; Conner, Michael; Yuan Kun; Dzodzo, Milorad B.; Karoutas, Zeses; Beltz, Steven A.; Ray, Sumit; Bissett, Teresa A. [Westinghouse Electric Company, Cranberry Township, PA 16066 (United States); Chieng, Ching-Chang, E-mail: cchieng@ess.nthu.edu.tw [National Tsing Hua University, Hsinchu 30043, Taiwan (China); Kao, Min-Tsung; Wu, Chung-Yun [National Tsing Hua University, Hsinchu 30043, Taiwan (China)

    2012-11-15

    One aspect of the AP1000{sup Registered-Sign} reactor design is the reduction in the number of major components and simplification in manufacturing. One design change relative to current Westinghouse reactors of similar size is the reduction in the number of reactor vessel outlet nozzles/hot legs leaving the upper plenum from three to two. With regard to fuel performance, this design difference creates a different flow field in the AP1000 reactor vessel upper plenum (the region above the core). The flow exiting core and entering the upper plenum must turn 90 Degree-Sign , flow laterally through the upper plenum around support structures, and exit through one of the two outlet nozzles. While the flow in the top of the core is mostly axial, there is some lateral flow component as the core flow reacts to the flow field and pressure distribution in the upper plenum. The pressure distribution in the upper plenum varies laterally depending upon various factors including the proximity to the outlet nozzles. To determine how the lateral flow in the top of the AP1000 core compares to current Westinghouse reactors, a computational fluid dynamics (CFD) model of the flow in the upper portion of the AP1000 reactor vessel including the top region of the core, the upper plenum, the reactor vessel outlet nozzles, and a portion of the hot legs was created. Due to geometric symmetry, the computational domain was reduced to a quarter (from the top view) that includes Vulgar-Fraction-One-Quarter of the top of the core, Vulgar-Fraction-One-Quarter of the upper plenum, and Vulgar-Fraction-One-Half of an outlet nozzle. Results from this model include predicted velocity fields and pressure distributions throughout the model domain. The flow patterns inside and around guide tubes clearly demonstrate the influence of lateral flow due to the presence of the outlet nozzles. From these results, comparisons of AP1000 flow versus current Westinghouse plants were performed. Field performance

  11. Transanal rectopexy - twelve case studies

    Directory of Open Access Journals (Sweden)

    Rubens Henrique Oleques Fernandes

    2012-06-01

    Full Text Available OBJECTIVES: This study analyzed the results of transanal rectopexy and showed the benefits of this surgical technique. METHOD: Twelve patients were submitted to rectopexy between 1997 and 2011. The surgical technique used was transanal rectopexy, where the mesorectum was fixed to the sacrum with nonabsorbable suture. Three patients had been submitted to previous surgery, two by the Delorme technique and one by the Thiersch technique. RESULTS: Postoperative hospital stay ranged from 1 to 4 days. One patient (8.3% had intraoperative hematoma, which was treated with local compression and antibiotics. One patient (8.3% had residual mucosal prolapse, which was resected. Prolapse recurrence was seen in one case (8.3%. Improved incontinence occurred in 75% of patients and one patient reported obstructed evacuation in the first month after surgery. No death occurred. CONCLUSION: Transanal rectopexy is a simple, low cost technique, which has shown good efficacy in rectal prolapse control.OBJETIVO: O presente estudo analisou os resultados da retopexia pela via transanal e expôs os benefícios desta técnica cirúrgica. MÉTODO: Doze pacientes com prolapso foram operados no período de 1997 a 2011. A técnica cirúrgica usada foi a retopexia transanal, onde o mesorreto foi fixado ao sacro com fio inabsorvível. Três pacientes tinham cirurgia prévia, dois pela técnica de Delorme e um pela técnica de Thiersch. RESULTADOS: A permanência hospitalar pós-operatória variou de 1- 4 dias. Uma paciente (8,3% apresentou hematoma transoperatório que foi tratado com compressão local e antibioticoterapia. Um paciente apresentou prolapso mucoso residual (8,3%, que foi ressecado. Houve recidiva da procidência em um caso (8,3%. A melhora da incontinência ocorreu em 75% dos pacientes e uma paciente apresentou bloqueio evacuatório no primeiro mês após a cirurgia. Não houve mortalidade entre os pacientes operados. CONCLUSÃO: A retopexia transanal é uma t

  12. On the dynamics of immobilized enzyme kinetics in a microreactor: A study of AP-catalyzed reactions

    Directory of Open Access Journals (Sweden)

    Pratap R Patnaik

    2011-11-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The kinetics of immobilized enzyme-catalyzed reactions in microreactors differ from those in macro-scale reactors. Recognizing this, a recent study (Patnaik 2011 based on a new interpretation of the kinetics of AP-catalyzed reactions showed that dynamic behavior is feasible only certain loci relating key kinetic parameters. That work has been extended here, and the kinetic parameters have now been related to bulk phase concentrations, thereby providing a link with the reaction system per se. It has also been shown that under certain conditions the reaction may become self-quenching but either monotonically or as damped oscillations. These two studies thus establish the importance of understanding kinetic dynamics in microreactors and in selecting feasible operating conditions.

  13. APS and Open Access

    Science.gov (United States)

    2011-03-01

    The movement toward Open Access continues to gain momentum. A brief review of APS efforts in this area will be presented by APS Editor in Chief, Gene Sprouse. Editors from Physical Review A, B, E, Focus, Letters, and X, Reviews of Modern Physics, and Physics will address your questions about publishing in this evolving environment.

  14. Paraplegia and intracranial hypertension following epidural anesthesia: report of four cases Paraplegia e hipertensão craniana após anestesia epidural: relato de 4 casos

    Directory of Open Access Journals (Sweden)

    Frederico A. D. Kliemann

    1975-09-01

    Full Text Available Four patients who received epidural anesthesia presented sustained myelopathy; three of them had complete paraplegia and one a lumbo-sacral myelopathy with urinary retention. All four patients complained of very intense radicular pains immediately after the analgesic effect of Lidocaine was over. Two patients in whom lumbar puncture was done in the first 24 hours presented an aseptic meningitic reaction in CSF. Paraplegia completed in two to ten months in three patients and in two of them severe intracranial hypertension developped at this time. It is proposed that the disease runs a two-stages course, at least in some cases, characterized by an aseptic meningitis, followed, after a silent period of some months, by signs of adhesive spinal and intracranial arachnoiditis. Intracranial hypertension was controlled by ventriculo-peritoneal shunt; in two patients a transitory effect of intrathecal injections of methyl-prednisolone acetate was observed. Two patients recovered almost completely from paraplegia.Quatro pacientes que receberam anestesia epidural apresentaram mielopatia de longa evolução; em três ocorreu paraplegia completa e um apresentou uma síndrome medular lombo-sacra com retenção urinária. Todos os pacientes se queixaram de intensas dores radiculares imediatamente após a cessação do efeito analgésico da lidocaína. Dois pacientes apresentaram uma reação meningítica asséptica no líquido cefalorraqueano nas primeiras 24 horas. A paraplegia tornou-se completa em 2 a 10 meses após a anestesia; dois pacientes tiveram hipertensão craniana severa. Em alguns casos, senão em todos, esta afecção apresenta uma evolução em duas etapas, caracterizadas por meningite asséptica imediata, seguida, depois de um período silencioso de poucos meses, de sinais de aracnoidite adesiva espinal e intracraniana. A hipertensão intracraniana foi controlada por derivação ventriculo-peritoneal; em 2 pacientes houve melhora transit

  15. Program evaluation and case study

    OpenAIRE

    Kushner, S

    2009-01-01

    This entry looks at the convergence of case study methodology and program evaluation. An early insight of some educational evaluation theorists was of the convergence of case study and program evaluation – the fusion of method with purpose. Program evaluation and case study came to be mutually-bracketed. In the educational evaluation field 'Responsive', 'Democratic', 'Illuminative' methodologies were developed in parallel with case study methods - the same authors contributing freely to both ...

  16. Examples and Case Studies

    NARCIS (Netherlands)

    Asbach, C.; Aguerre, O.; Bressot, C.; Brouwer, D.H.; Gommel, U.; Gorbunov, B.; Bihan, O. le; Jensen, K.A.; Kaminski, H.; Keller, M.; Koponen, I.K.; Kuhlbusch, T.A.J.; Lecloux, A.; Morgeneyer, M.; Muir, R.; Shandilya, N.; Stahlmecke, B.; Todea, A.M.

    2014-01-01

    Release of nanomaterials may occur during any stage of the life-cycle and can eventually lead to exposure to humans, the environment or products. Due to the large number of combinations of release processes and nanomaterials, release scenarios can currently only be tested on a case-by-case basis. Th

  17. Final report on case studies

    DEFF Research Database (Denmark)

    Ljungberg, Daniel; McKelvey, Maureen; Lassen, Astrid Heidemann

    2012-01-01

    Case study as a research design means investigating a single or multiple instance(s) or setting(s) (i.e. a case) and its entire context to explain a phenomenon and its processes. This is achieved through detailed understanding, usually comprised of multiple sources of information. In this way, case...... studies attempt to provide as a complete an understanding of a (complex) phenomenon as possible. Within the AEGIS project, survey and case study research are complementary. They are complementary in the sense that the former can provide more generalizable evidence on a phenomenon in terms of cross......-sectional data, while the latter can provide more in-depth (qualitative) understanding on specific issues. In systematically examining the case studies, however, this report goes beyond a typical single case study. Here we provide a synthesis of 86 case studies. Multiple case studies, following similar focus...

  18. Natural Learning Case Study Archives

    Science.gov (United States)

    Lawler, Robert W.

    2015-01-01

    Natural Learning Case Study Archives (NLCSA) is a research facility for those interested in using case study analysis to deepen their understanding of common sense knowledge and natural learning (how the mind interacts with everyday experiences to develop common sense knowledge). The database comprises three case study corpora based on experiences…

  19. Dioxin: a case study.

    Science.gov (United States)

    Bond, G G

    1993-01-01

    The need to notify individuals of a possible health risk from their past exposure to potentially hazardous agents frequently extends beyond workers to include community groups. The issues to consider in community notification are frequently similar to those that are important for worker notification but may include some that are unique. This case study traces the evolution of one company's strategy for communicating with the public about possible dioxin contamination associated with its operations. Early communications tended to emphasize the technical aspects of the issues in the fashion of scientists talking to other scientists. This was interpreted by some to be symptomatic of an arrogant and uncaring attitude. Beginning in the early 1980s, the company's management recognized the need to reach out to a variety of audiences on multiple levels, and shifted to a more comprehensive communications strategy. A similar shift is now occurring throughout the chemical manufacturing industry as top managers realize that, if they expect to continue to operate, they must become more accountable and responsive to the public.

  20. AP calculus AB & BC crash course

    CERN Document Server

    Rosebush, J

    2012-01-01

    AP Calculus AB & BC Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP Calculus AB & BC Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP Calculus AB & BC course description outline and actual AP test questions. It covers only the information tested on the exams, so you can make the most of your valuable study time. Written by experienced math teachers, our

  1. Glossary for the implementation of Health in All Policies (HiAP).

    Science.gov (United States)

    Freiler, Alix; Muntaner, Carles; Shankardass, Ketan; Mah, Catherine L; Molnar, Agnes; Renahy, Emilie; O'Campo, Patricia

    2013-12-01

    Health in All Policies (HiAP) is becoming increasingly popular as a governmental strategy to improve population health by coordinating action across health and non-health sectors. A variety of intersectoral initiatives may be used in HiAP that frame health determinants as the bridge between policies and health outcomes. The purpose of this glossary is to present concepts and terms useful in understanding the implementation of HiAP as a cross-sectoral policy. The concepts presented here were applied and elaborated over the course of case studies of HiAP in multiple jurisdictions, which used key informant interviews and the systematic review of literature to study the implementation of specific HiAP initiatives.

  2. 耐甲氧西林金黄色葡萄球菌感染病例对经济损失与住院日影响的对照研究%Case-control study of influence of methicillin-resistant St ap hy lococcus aureus infection on economic losses and length of hospital stay

    Institute of Scientific and Technical Information of China (English)

    傅建国; 陈宝勤; 王雪莲; 叶清星; 卢珍玲; 苏成豪; 牛建军

    2014-01-01

    目的:探讨耐甲氧西林金黄色葡萄球菌(MRSA)和甲氧西林敏感金黄色葡萄球菌(MSSA)感染造成的经济损失。方法回顾性调查2012年1月-2013年12月456例MRSA感染和250例MSSA感染患者的住院费用与住院天数,并按照1∶1匹配设立对照组,比较各组的住院费用和住院天数。结果 MRSA感染组、MSSA感染组住院费用分别增加82694.8元和18735.3元,延长住院天数14.1 d和5.9 d;IC U中M RS A感染增加费用最高,为153344.5元,延长住院天数则以外科明显;60~75岁M RS A造成的直接经济损失最高,达100208.9元,延长住院天数22 d;MSSA感染造成的经济损失则以>75岁组最大,直接经济损失23914.4元,延长住院天数6.9 d。结论 M RS A感染增加患者经济负担,延长住院时间,同时也影响医院病床周转率。%OBJECTIVE To evaluate the direct economic losses caused by the methicillin-resistant Staphylococcus aureus (MRSA) infection and the methicillin-sensitive Staphylococcus aureus (MSSA) infection .METHODS A total of 456 patients with MRSA infection and 250 patients with MSSA infection ,who were treated in the hospital from Jan 2012 to Dec 2013 ,were enrolled in the study ,then the hospitalization cost and the length of hospital stay of the subjects were retrospectively investigated , the control group was set up in a 1 ∶ 1 ratio , and the hospitalization cost and the length of hospital stay were compared .RESULTS The hospitalization cost of the patients with MRSA infections increased by 82 694 .8 yuan ,the patients with MSSA infections 18 735 .3 yuan;the prolonged length of hospital stay of the patients with MRSA infections was 14 .1 days ,the patients with MSSA infection 5 .9 days;the increase of the hospitalization cost of the patients with MRSA infections was highest in the ICU ( 153 344 .5 yuan) ,and the prolonged length of hospital stay was longest in the department of surgery .The

  3. APS Science 2006.

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, J. M.; Fenner, R. B.; Long, G.; Borland, M.; Decker, G.

    2007-05-24

    In my five years as the Director of the Advanced Photon Source (APS), I have been fortunate to see major growth in the scientific impact from the APS. This year I am particularly enthusiastic about prospects for our longer-term future. Every scientific instrument must remain at the cutting edge to flourish. Our plans for the next generation of APS--an APS upgrade--got seriously in gear this year with strong encouragement from our users and sponsors. The most promising avenue that has emerged is the energy-recovery linac (ERL) (see article on page xx), for which we are beginning serious R&D. The ERL{at}APS would offer revolutionary performance, especially for x-ray imaging and ultrafast science, while not seriously disrupting the existing user base. I am very proud of our accelerator physics and engineering staff, who not only keep the current APS at the forefront, but were able to greatly impress our international Machine Advisory Committee with the quality of their work on the possible upgrade option (see page xx). As we prepare for long-term major upgrades, our plans to develop and optimize all the sectors at APS in the near future are advancing. Several new beamlines saw first light this year, including a dedicated powder diffraction beamline (11-BM), two instruments for inelastic x-ray scattering at sector 30, and the Center for Nanoscale Materials (CNM) Nanoprobe beamline at sector 26. Our partnership in the first x-ray free-electron laser (LCLS) to be built at Stanford contributes to revolutionary growth in ultrafast science (see page xx), and we are developing a pulse chirping scheme to get ps pulses at sector 7 of the APS within a year or so. In this report, you will find selected highlights of scientific research at the APS from calendar year 2006. The highlighted work covers diverse disciplines, from fundamental to applied science. In the article on page xx you can see the direct impact of APS research on technology. Several new products have emerged from

  4. Gravidez ectópica após uso de contracepção de emergência: relato de caso Ectopic pregnancy after use of hormonal emergency contraception: a case report

    Directory of Open Access Journals (Sweden)

    Renato Monteiro Zucchi

    2004-10-01

    Full Text Available Gravidez ectópica é a implantação e o desenvolvimento do ovo fora da cavidade uterina; impõe diagnóstico precoce e assistência de urgência. Gravidez ectópica com corpo lúteo contralateral presume ocorrência de transmigração do zigoto para a tuba uterina do lado oposto, o que pode ser responsável pela sua ocorrência. Em 1994, o levonorgestrel teve sua eficácia comprovada como superior à dos outros métodos para contracepção de emergência. É relatado caso de paciente de 27 anos que apresentou gravidez ectópica, de localização tubária, com corpo lúteo contralateral, após uso de contracepção de emergência por falha do método anticoncepcional de escolha (preservativo masculino. Foi realizado tratamento cirúrgico conservador por videolaparoscopia, com boa evolução após a cirurgia.Ectopic pregnancy is the implantation and development of the ovum outside the uterine cavity; it needs a quick diagnosis and an urgent treatment. The presence of the corpus luteum in the ovary that is contralateral to the ectopic pregnancy is presumptive evidence for ovum transmigration, which may be the cause of ectopic pregnancy. In 1994, a multinational clinical trial proved the superiority of levonorgestrel over the existing emergency contraceptive products. In the present study, we describe the case of a 27-year-old woman with ectopic pregnancy and a contralateral corpus luteum after use of hormonal emergency contraception (levonorgestrel, because of failure of the used contraception method (condom. The patient was treated with laparoscopic surgery that was successful.

  5. Intercultural Communicative Case Study

    Institute of Scientific and Technical Information of China (English)

    吴冬梅

    2009-01-01

    The essay is mainly about the author's comprehension of cultural differences and intercultural communication after reading the book Communication Between Cultures.In addition,the author also analyses three cases with the theories and approaches mentioned in Communication Between Cultures.

  6. Emotion, Engagement, and Case Studies

    Science.gov (United States)

    Herreid, Clyde Freeman; Terry, David R.; Lemons, Paula; Armstrong, Norris; Brickman, Peggy; Ribbens, Eric

    2014-01-01

    Three college faculty taught large general biology classes using case studies and personal response systems (clickers). Each instructor taught the same eight cases in two different sections, except the questions within the cases differed. In one section the questions were lower order (LO) factual inquiries, and in the other they were largely…

  7. Case Study: Case Studies and the Flipped Classroom

    Science.gov (United States)

    Herreid, Clyde Freeman; Schiller, Nancy A.

    2013-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue discusses the positive and negative aspects of the "flipped classroom." In the flipped classroom model, what is normally done in class and what is normally done as…

  8. Building theories from case study research: the progressive case study

    NARCIS (Netherlands)

    Steenhuis, Harm-Jan; Bruijn, de Erik J.

    2006-01-01

    Meredith (1998) argues for more case and field research studies in the field of operations management. Based on a literature review, we discuss several existing approaches to case studies and their characteristics. These approaches include; the Grounded Theory approach which proposes no prior litera

  9. Theory Testing Using Case Studies

    DEFF Research Database (Denmark)

    Møller, Ann-Kristina Løkke; Dissing Sørensen, Pernille

    2014-01-01

    testing using case studies, including the associated research goal, analysis, and generalisability. We argue that research designs for theory testing using case studies differ from theorybuilding case study research designs because different research projects serve different purposes and follow different......The appropriateness of case studies as a tool for theory testing is still a controversial issue, and discussions about the weaknesses of such research designs have previously taken precedence over those about its strengths. The purpose of the paper is to examine and revive the approach of theory...... research paths....

  10. Contratura cicatricial severa em membros superiores após queimadura por escaldamento: relato de caso = Severe upper extremities burn scar contractures after a scald burn: case report

    OpenAIRE

    2013-01-01

    Objetivos: Descrever a história e o tratamento de um menino com severa contratura cicatricial em membros superiores após queimadura. Descrição do caso: Paciente de seis anos que evoluiu com importantes contraturas cicatriciais em tronco e membros superiores após queimadura por escaldamento. Foi realizado tratamento cirúrgico através de múltiplas zetaplastias em mais de um tempo cirúrgico, com resultado funcional satisfatório. Conclusões: As contraturas cicatriciais são complicações comu...

  11. Guillain-Barré syndrome after brachial plexus trauma: case report Síndrome de Guillain-Barré após traumatismo de plexo braquial: relato de caso

    Directory of Open Access Journals (Sweden)

    Marcos R.G. de Freitas

    2006-12-01

    Full Text Available The Guilllain-Barré syndrome (GBS is an acute predominantly demyelinating polyneuropathy. In many cases GBS is preceding by infection, immunization, surgery or trauma. Although there are a few reports of GBS after head trauma, there is no report of this syndrome after brachial plexus injury. We report on a 51 years-old man who presented GBS fifteen days after a brachial plexus trauma. The polineuropathy resolved completely in a few weeks. We believe that GBS was triggered by the trauma that evoked an immune mediated disorder producing inflammation and demyelination of the peripheral nerves.A síndrome de Guillain-Barré (SGB é uma polineuropatia predominantemente desmielinizante, que ocorre na maioria das vezes após uma infecção, vacinação, cirurgia ou traumatismo. Embora tenham sido descritos alguns casos após traumatismo crânio encefálico, ainda não foi referido caso de SGB após traumatismo do plexo braquial. Relatamos o caso de um homem de 51 anos que 15 dias após ter apresentado paralisia traumática do plexo braquial, desenvolveu SGB. Recuperou-se inteiramente em algumas semanas. Achamos que em nosso caso a SGB foi desencadeada pelo traumatismo, que provocou distúrbios imunológicos com conseqüente acometimento dos nervos periféricos.

  12. Theory testing using case studies

    DEFF Research Database (Denmark)

    Dissing Sørensen, Pernille; Løkke Nielsen, Ann-Kristina

    Case studies may have different research goals. One such goal is the testing of small-scale and middle-range theories. Theory testing refers to the critical examination, observation, and evaluation of the 'why' and 'how' of a specified phenomenon in a particular setting. In this paper, we focus...... on the strengths of theory-testing case studies. We specify research paths associated with theory testing in case studies and present a coherent argument for the logic of theoretical development and refinement using case studies. We emphasize different uses of rival explanations and their implications for research...... design. Finally, we discuss the epistemological logic, i.e., the value to larger research programmes, of such studies and, following Lakatos, conclude that the value of theory-testing case studies lies beyond naïve falsification and in their contribution to developing research programmes in a progressive...

  13. Instructional Computing: Ten Case Studies.

    Science.gov (United States)

    Hargan, Carol; Hunter, Beverly

    These case studies are written for educational institutions that wish to plan, extend, or improve their use of computers for learning and teaching. Each case study includes a brief description of each of the following: profile of the institution, history of the development of instructional computing, organization and management, student access to…

  14. Three Community College Case Studies

    Science.gov (United States)

    Wojtysiak, Joseph; Sutton, William J., II; Wright, Tommy; Brantley, Linda

    2011-01-01

    This article presents three case studies that focus on specific projects that are underway or have been completed. In the first case study, Joseph Wojtysiak and William J. Sutton, II discuss the Green Center of Central Pennsylvania, which is designed to serve as the state's preeminent source for education, training and public information about…

  15. Endoftalmite por Candida albicans após transplante penetrante de córnea: relato de caso Candida albicans endophthalmitis following penetrating corneal graft: case report

    Directory of Open Access Journals (Sweden)

    Glaucio de Godoy

    2004-04-01

    Full Text Available Os autores relatam o caso de uma paciente submetida a transplante penetrante de córnea por ceratocone que evoluiu com resposta inflamatória exacerbada durante o período pós-operatório, suspeitando-se, inicialmente, de rejeição atípica e intensa ao botão doador. Houve períodos de melhora, seguidos por períodos de piora a cada tentativa de se reduzir o corticóide tópico. Iniciou-se terapia imunossupressora com ciclosporina via oral e altas doses de corticóide tópico, porém, a paciente desenvolveu endoftalmite por Candida albicans com acometimento do segmento anterior do olho e do corpo vítreo, mas sem surgimento de lesões coriorretinianas. Evoluiu de forma satisfatória após três injeções de anfotericina B 5µg intravítrea, cetoconazol 400 mg/dia via oral e clotrimazol tópico de 4/4 horas. Os autores discutem também as principais possibilidades de contaminação da paciente, sendo o quadro infeccioso provavelmente relacionado ao procedimento cirúrgico.The authors report a case of a patient submitted to penetrating corneal graft for keratoconus with an exaggerated inflammatory response during the postoperative period. The patient was suspected of having an atypical rejection to the donor button. There were periods of improvement, followed by periods of worsening of the inflammation at each attempt of reducing the topical corticosteroid. After initiating immunosuppressive therapy with cyclosporin and high doses of topical corticosteroid, the patient developed Candida albicans endophthalmitis affecting the anterior segment of the eye and the vitreous body, but sparing the chorioretina. The patient improved after three injections of 5 µg intravitreal amphotericin B, 400 mg oral ketoconazole daily and topical clotrimazole every four hours. The authors also discuss the main possibilities of contamination of the patient, the infectious picture probably being related to the surgical procedure.

  16. Strengthening the implementation of Health in All Policies: a methodology for realist explanatory case studies.

    Science.gov (United States)

    Shankardass, Ketan; Renahy, Emilie; Muntaner, Carles; O'Campo, Patricia

    2015-05-01

    To address macro-social and economic determinants of health and equity, there has been growing use of intersectoral action by governments around the world. Health in All Policies (HiAP) initiatives are a special case where governments use cross-sectoral structures and relationships to systematically address health in policymaking by targeting broad health determinants rather than health services alone. Although many examples of HiAP have emerged in recent decades, the reasons for their successful implementation--and for implementation failures--have not been systematically studied. Consequently, rigorous evidence based on systematic research of the social mechanisms that have regularly enabled or hindered implementation in different jurisdictions is sparse. We describe a novel methodology for explanatory case studies that use a scientific realist perspective to study the implementation of HiAP. Our methodology begins with the formulation of a conceptual framework to describe contexts, social mechanisms and outcomes of relevance to the sustainable implementation of HiAP. We then describe the process of systematically explaining phenomena of interest using evidence from literature and key informant interviews, and looking for patterns and themes. Finally, we present a comparative example of how Health Impact Assessment tools have been utilized in Sweden and Quebec to illustrate how this methodology uses evidence to first describe successful practices for implementation of HiAP and then refine the initial framework. The methodology that we describe helps researchers to identify and triangulate rich evidence describing social mechanisms and salient contextual factors that characterize successful practices in implementing HiAP in specific jurisdictions. This methodology can be applied to study the implementation of HiAP and other forms of intersectoral action to reduce health inequities involving multiple geographic levels of government in diverse settings.

  17. Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations (II): thrombocytopenia and skin manifestations.

    Science.gov (United States)

    Cervera, R; Tektonidou, M G; Espinosa, G; Cabral, A R; González, E B; Erkan, D; Vadya, S; Adrogué, H E; Solomon, M; Zandman-Goddard, G; Shoenfeld, Y

    2011-02-01

    The objectives of the 'Task Force on Catastrophic Antiphospholipid Syndrome (APS) and Non-criteria APS Manifestations' were to assess the clinical utility of the international consensus statement on classification criteria and treatment guidelines for the catastrophic APS, to identify and grade the studies that analyze the relationship between the antiphospholipid antibodies and the non-criteria APS manifestations, and to present the current evidence regarding the accuracy of these non-criteria APS manifestations for the detection of patients with APS. This article summarizes the studies analyzed on thrombocytopenia and skin manifestations, and presents the recommendations elaborated by the Task Force after this analysis.

  18. A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced stage solid cancers – A California Cancer Consortium Study

    Science.gov (United States)

    Chao, Joseph; Synold, Timothy W.; Morgan, Robert J.; Kunos, Charles; Longmate, Jeff; Lenz, Heinz-Josef; Lim, Dean; Shibata, Stephen; Chung, Vincent; Stoller, Ronald G.; Belani, Chandra P.; Gandara, David R.; McNamara, Mark; Gitlitz, Barbara J.; Lau, Derick H.; Ramalingam, Suresh S.; Davies, Angela; Espinoza-Delgado, Igor; Newman, Edward M.; Yen, Yun

    2012-01-01

    Background 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) is a novel small molecule ribonucleotide reductase inhibitor. This study was designed to estimate the maximum-tolerated dose (MTD) and oral bioavailability of 3-AP in patients with advanced stage solid tumors. Methods Twenty patients received one dose of intravenous and subsequent cycles of oral 3-AP following a 3+3 patient dose-escalation. Intravenous 3-AP was administered to every patient at a fixed dose of 100 mg over a 2-hour infusion 1 week prior to the first oral cycle. Oral 3-AP was administered every 12 hours for 5 consecutive doses on days 1–3, days 8–10, and days 15–17 of every 28-day cycle. 3-AP was started at 50 mg with a planned dose escalation to 100, 150, and 200 mg. Dose-limiting toxicities (DLT) and bioavailability were evaluated. Results Twenty patients were enrolled. For dose level 1 (50mg), the second of three treated patients had a DLT of grade 3 hypertension. In the dose level 1 expansion cohort, three patients had no DLTs. No further DLTs were encountered during escalation until the 200 mg dose was reached. At the 200 mg 3-AP dose level, two treated patients had DLTs of grade 3 hypoxia. One additional DLT of grade 4 febrile neutropenia was subsequently observed at the de-escalated 150 mg dose. One DLT in 6 evaluable patients established the MTD as 150 mg per dose on this dosing schedule. Responses in the form of stable disease occurred in 5 (25%) of 20 patients. The oral bioavailability of 3-AP was 67 ± 29%, and was consistent with the finding that the MTD by the oral route was 33% higher than by the intravenous route. Conclusions Oral 3-AP is well-tolerated and has an MTD similar to its intravenous form after accounting for the oral bioavailability. Oral 3-AP is associated with a modest clinical benefit rate of 25% in our treated patient population with advanced solid tumors. PMID:22105720

  19. Roundabouts Canada case study

    Energy Technology Data Exchange (ETDEWEB)

    Jamieson, M. [Ryerson Polytechnic Univ., Toronto, ON (Canada); Lenters, M. [Roundabouts Canada, Whitby, ON (Canada)

    2002-07-01

    A modern roundabout was constructed in the community of Ancaster, Ontario in response to growing complaints regarding speeding along the major roadway, and queuing on the minor roadway. The roundabout opened on October 25, 2002. The before and after speeds at the roundabout are being studied, and the fastest path characteristics are assessed in an effort to determine whether the predicted fastest path data correlates with the in-service operating speeds. The speed at R1, R2 and R3 locations on the east west, and north south approaches are measured. tabs., figs.

  20. Case Studies in Science Ethics

    Science.gov (United States)

    Williams, Karen

    2010-03-01

    Everyone in science should have ethics education training. I have seen graduate students taken advantage of by their mentors. Many of us have seen misconduct...but what should we do about it? Young scientists are often unaware of the rules in science and make mistakes because of their ignorance of the rules in that particular field of study. Then there are an increasing number of cases in the news of overt cases of misrepresentation in science. All are welcome to attend this discussion of case studies. A case study on topics such as: how to treat data properly, how our values in science affect our work, who gets authorship on scientific papers, who is first author on a paper, what you should do if you uncover misconduct or plagiarism in your university, and we will discuss the scientist's role in society. This will be a painless, non-confrontational small group, then large group discussion of each case

  1. Hydrogeologic Case Studies (Seattle, WA)

    Science.gov (United States)

    Hydrogeology is the foundation of subsurface site characterization for evaluations of monitored natural attenuation (MNA). Three case studies are presented. Examples of the potentially detrimental effects of drilling additives on ground-water samples from monitoring wells are d...

  2. Nasopharyngeal Case-Control Study

    Science.gov (United States)

    A case-control study conducted in Taiwan between 1991-1994 among approximately 1,000 individuals to examine the role of viral, environmental, and genetic factors associated with the development of nasopharyngeal carcinoma

  3. Case Studies in Strategic Planning

    Science.gov (United States)

    1990-03-06

    Contains developed case studies in strategic planning on The Navy General Board, Joint Service War Planning 1919 to 1941, Navy Strategic Planning , NASA...in Strategic Planning NPS-56-88-031-PR of September 1988. Strategic planning , Strategic Management.

  4. Case Study: del Amo Bioventing

    Science.gov (United States)

    The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study.

  5. Unilateral dysphotopsia after bilateral intraocular lens implantation using the AR40e IOL model: case report Disfotopsia unilateral após implante bilateral de lente intra-ocular modelo AR40e: relato de caso

    Directory of Open Access Journals (Sweden)

    Frederico França Marques

    2007-03-01

    Full Text Available The authors report a recent complication during the postoperative period of cataract surgery. A patient was submitted to cataract surgery in both eyes with IOL implantation (Sensar® inside the capsular bag. The postoperative period of right eye was uneventful, however, in the left eye the patient noted a dark shadow at the temporal visual field at the first postoperative week. This diagnosis was confirmed with the presence of a temporal scotoma revealed by the computerized visual field (first reported in this study and also reducing the pupil area with miotic drops. The treatment of this complication was performed by using brimonidine tartrate and after 6 months this symptom completely disappeared as confirmed by the computerized visual field. The treatment should be based on reducing the pupil area with miotic drops and we also recommend to observe these cases until the 6th postoperative month before indicating an IOL exchange since the capsular edge that overlaps the IOL may opacify creating an optical barrier reducing or eliminating negative dysphotopsia.Os autores relatam uma complicação no período pós-operatório relativamente recente na cirurgia de catarata. Trata-se de paciente que foi submetido à cirurgia de catarata bilateral não simultânea com implante sacular da lente intra-ocular (Sensar®. O pós-operatório do olho direito evoluiu sem nenhuma queixa, entretanto, no olho esquerdo o paciente referiu a presença de uma sombra em campo visual temporal na primeira semana de pós-operatório sendo diagnosticado disfotopsia negativa após exclusão de outras causas oculares, principalmente retinianas. Este diagnóstico foi confirmado com a presença de um escotoma temporal na campimetria visual computadorizada (relatado na literatura pela primeira vez neste estudo e também com a redução medicamentosa do tamanho da pupila. Seu tratamento foi realizado com a administração de tartarato de brimonidina e após 6 meses o sintoma

  6. AP English language & composition crash course

    CERN Document Server

    Hogue, Dawn

    2012-01-01

    AP English Language & Composition Crash Course - Gets You a Higher Advanced Placement Score in Less Time Crash Course is perfect for the time-crunched student, the last-minute studier, or anyone who wants a refresher on the subject. AP English Language & Composition Crash Course gives you: Targeted, Focused Review - Study Only What You Need to Know Crash Course is based on an in-depth analysis of the AP English Language & Composition course description outline and actual Advanced Placement test questions. It covers only the information tested on the exam, so you can make the most of your valua

  7. Late recurrent iris synechia following laser goniopuncture for deep sclerectomy enhancement: case report Sinéquia iriana tardia após goniopunctura a laser para esclerectomia profunda não penetrante: relato de caso

    Directory of Open Access Journals (Sweden)

    Christiana Rebello Hilgert

    2012-12-01

    Full Text Available We report a case of recurrent iris synechiae one year after Nd:YAG laser goniopuncture for deep sclerectomy enhancement in the only functional eye of a patient with end-stage glaucoma. The possible pathophysiology of this uncommon complication and laser treatment aspects are discussed.A ocorrência de sinéquias irianas após goniopunctura a laser com finalidade de aumentar a filtração após esclerectomia não penetrante é evento raro e que pode levar à crise glaucomatosa aguda e suas consequências. Relatamos a ocorrência deste evento em olho único de paciente portadora de glaucoma em estágio final, um ano após a realização de goniopunctura. Os possíveis mecanismos fisiopatológicos desta complicação incomum, assim como aspectos do tratamento a laser para reverter o quadro são discutidos.

  8. Biophysical studies of the membrane location of the voltage-gated sensors in the HsapBK and KvAP K(+) channels.

    Science.gov (United States)

    Biverståhl, Henrik; Lind, Jesper; Bodor, Andrea; Mäler, Lena

    2009-09-01

    The membrane location of two fragments in two different K(+)-channels, the KvAP (from Aeropyrum pernix) and the HsapBK (human) corresponding to the putative "paddle" domains, has been investigated by CD, fluorescence and NMR spectroscopy. Both domains interact with q = 0.5 phospholipid bicelles, DHPC micelles and with POPC vesicles. CD spectra demonstrate that both peptides become largely helical in the presence of phospholipid bicelles. Fluorescence quenching studies using soluble acrylamide or lipid-attached doxyl-groups show that the arginine-rich domains are located within the bilayered region in phospholipid bicelles. Nuclear magnetic relaxation parameters, T(1) and (13)C-(1)H NOE, for DMPC in DMPC/DHPC bicelles and for DHPC in micelles showed that the lipid acyl chains in the bicelles become less flexible in the presence of either of the fragments. An even more pronounced effect is seen on the glycerol carbons. (2)H NMR spectra of magnetically aligned bicelles showed that the peptide derived from KvAP had no or little effect on bilayer order, while the peptide derived from HsapBK had the effect of lowering the order of the bilayer. The present study demonstrates that the fragments derived from the full-length proteins interact with the bilayered interior of model membranes, and that they affect both the local mobility and lipid order of model membrane systems.

  9. Study on Early Phase of AP1000 Accident Under Fukushima Condition%福岛条件下 AP1000核电厂事故前期研究

    Institute of Scientific and Technical Information of China (English)

    杨江; 王婷; 陶俊; 高玲媛; 卢向晖

    2014-01-01

    假设AP1000核电厂发生类似福岛核事故的初因事件,利用RELAP5/MOD3.3程序对事故早期的一、二回路系统和非能动安全系统进行模拟计算,得到了反应堆冷却剂系统压力、堆芯冷却剂温度、非能动安全系统流量等重要参数的瞬态变化。分析表明:在非能动余热排出系统完好的情况下,反应堆系统能顺利进入热停堆状态;如果非能动余热排出系统1根换热管发生双端断裂,则反应堆系统将会在5h内发生严重事故。%Simulation calculations of AP1000 nuclear power plant consisting of the pri-mary and secondary loop systems , and the passive safety systems with RELAP5/MOD3.3 code were performed under the assumption of Fukushima nuclear accident . Some key transient parameters including RCS pressure ,core coolant temperature ,and passive safety system flow were obtained .The analysis results show that the AP1000 reactor can reach hot shutdow n status with the passive residual heat removal system (PRHRS) available;however the reactor will undergo severe accident in five hours with the assumption of double-ended rupture of one PRHRS tube .

  10. AIRE variations in Addison's disease and autoimmune polyendocrine syndromes (APS)

    DEFF Research Database (Denmark)

    Bøe Wolff, A S; Oftedal, B; Johansson, S

    2008-01-01

    Autoimmune Addison's disease (AAD) is often associated with other components in autoimmune polyendocrine syndromes (APS). Whereas APS I is caused by mutations in the AIRE gene, the susceptibility genes for AAD and APS II are unclear. In the present study, we investigated whether polymorphisms...... or copy number variations in the AIRE gene were associated with AAD and APS II. First, nine SNPs in the AIRE gene were analyzed in 311 patients with AAD and APS II and 521 healthy controls, identifying no associated risk. Second, in a subgroup of 25 of these patients, AIRE sequencing revealed three novel...... polymorphisms. Finally, the AIRE copy number was determined by duplex quantitative PCR in 14 patients with APS I, 161 patients with AAD and APS II and in 39 healthy subjects. In two Scandinavian APS I patients previously reported to be homozygous for common AIRE mutations, we identified large deletions...

  11. Contratura cicatricial severa em membros superiores após queimadura por escaldamento: relato de caso = Severe upper extremities burn scar contractures after a scald burn: case report

    Directory of Open Access Journals (Sweden)

    Laitano, Francisco Felipe

    2013-01-01

    Conclusões: As contraturas cicatriciais são complicações comuns após queimaduras e devem ser manejadas individualmente. A melhor forma de preveni-las é seguir um tratamento baseado em protocolos para pacientes queimados graves. No tratamento das contraturas deve-se sempre iniciar o manejo através da modalidade mais simples e resolutiva para cada caso. No caso relatado foram utilizados apenas zetaplastias e enxertos de pele parcial, obtendo-se um resultado eficaz com mínima morbidade e importante melhora na qualidade de vida do paciente

  12. Antiphospholipid syndrome (APS) revisited: Would migraine headaches be included in future classification criteria?

    Science.gov (United States)

    Noureldine, Mohammad Hassan A; Haydar, Ali A; Berjawi, Ahmad; Elnawar, Rody; Sweid, Ahmad; Khamashta, Munther A; Hughes, Graham R V; Uthman, Imad

    2016-07-16

    Headaches have been extensively reported in Antiphospholipid syndrome (APS)/Antiphospholipid antibodies (aPL)-positive patients. The aim of this study was to highlight the prevalence of headaches among APS/aPL-positive patients and discuss its association with laboratory, clinical and imaging findings. We searched the literature through Google Scholar and PubMed for publications on the epidemiology, pathogenesis, laboratory, imaging and clinical findings, and management of headaches in APS/aPL-positive patients. The following keywords were used: Antiphospholipid, Hughes syndrome, anticardiolipin, lupus anticoagulant, anti-β2 glycoprotein I, headache, migraine, tension, and cluster. All reports published between 1969 and 2015 were included. Migraine is the most commonly reported type of headache in APS/aPL-positive patients. Thrombotic and platelet dysfunction hypotheses have been studied to uncover the pathogenic role of aPL in the development of headaches. Several studies are reporting higher levels of aPL in primary and secondary APS migraineurs, but only few reached statistical significance. Migraine patients without clinical signs/symptoms of cerebral infarction rarely show positive imaging findings. Digital subtraction angiography shows promise in demonstrating small vascular lesions otherwise not detected on computed tomography, magnetic resonance imaging, or cerebral angiograms. Although it may be solitary and harmless in many cases, the deleterious effect of migraine on the quality of life of APS patients prompts rapid diagnosis and proper management. An anticoagulation trial is advisable in APS patients with migraine as many cases of severe, refractory migraine resolved with anticoagulation therapy. The profile of migraine headaches discussed in this study permits its candidacy for inclusion in future APS classification criteria.

  13. Purification and study of the functions of pAp Phosphatase of Streptococcus mutans%变异链球菌腺苷磷酸硫酸酶的原核表达及功能研究

    Institute of Scientific and Technical Information of China (English)

    张加勤; 侯香华; 宋秀宇

    2012-01-01

    His-tagged APS protein can convert pAp to AMP and inorganic phosphate in vitro in the presence of Mg2+ or Mn2+ , but it cannot degrade Cy5-tagged RNA oligos even in the presence of high concentrations of Mg2+ or Mn2+. Conclusion S. mutans APS yielded time and dose-dependent pAp phosphatase activity in vitro. This study provides grounds for the further investigation of the function of the S. mutans aps gene.

  14. eCompetence Case Studies

    DEFF Research Database (Denmark)

    Jensen, Helle Bækkelund

    2006-01-01

    In this paper we present some details of the processes undertaken in the European eCompetence Initiative. We present two illustrative and representative case studies. The research aims to identify and understand patterns of individual and organisational eCompetence approaches.......In this paper we present some details of the processes undertaken in the European eCompetence Initiative. We present two illustrative and representative case studies. The research aims to identify and understand patterns of individual and organisational eCompetence approaches....

  15. Case Study on Logistics Performance

    Directory of Open Access Journals (Sweden)

    Shahryar Sorooshian

    2013-05-01

    Full Text Available The paper presents research carried out at a medium‐size manufacturing organization in east Asia. The study tries to highlight the importance of supply chain management; specifically, our aim for this study is to understand logistics and performance measurement in the logistics and supply chain, and we include a theoretical discussion of online data collected and a case study of the logistic performance of a real organization. The study also examines the performance of the selected company, identifies the problems and provides recommendations for improvements. This study can be a guide for business advisers and those interested in analysing company performance, especially from a logistics viewpoint. We also suggest the methodology of this case study for those who want to have a better understanding of a business environment before starting their own business, or for benchmarking practice during strategic planning.

  16. Teaching Case: Enterprise Architecture Specification Case Study

    Science.gov (United States)

    Steenkamp, Annette Lerine; Alawdah, Amal; Almasri, Osama; Gai, Keke; Khattab, Nidal; Swaby, Carval; Abaas, Ramy

    2013-01-01

    A graduate course in enterprise architecture had a team project component in which a real-world business case, provided by an industry sponsor, formed the basis of the project charter and the architecture statement of work. The paper aims to share the team project experience on developing the architecture specifications based on the business case…

  17. The APS ceramic chambers

    Energy Technology Data Exchange (ETDEWEB)

    Milton, S.; Warner, D.

    1994-07-01

    Ceramics chambers are used in the Advanced Photon Source (APS) machines at the locations of the pulsed kicker and bumper magnets. The ceramic will be coated internally with a resistive paste. The resistance is chosen to allow the low frequency pulsed magnet field to penetrate but not the high frequency components of the circulating beam. Another design goal was to keep the power density experienced by the resistive coating to a minimum. These ceramics, their associated hardware, the coating process, and our recent experiences with them are described.

  18. The Case Study of Frank

    Science.gov (United States)

    Eynde, Peter Op't; Hannula, Markku S.

    2006-01-01

    As a unifying feature of this Special Issue, we have asked proponents of each framework to analyse an empirical classroom account of one student's process of solving a mathematical problem. Here, for the case study of "Frank", we give the main data that were available to all authors.

  19. Case Studies in Sports Nutrition.

    Science.gov (United States)

    Clark, Nancy

    1988-01-01

    This article presents case studies of two athletes who wanted to affect a change in their body weight in order to enhance athletic performance. Each athlete's problem and the nutrition approach used to solve it are discussed. Caloric values of fast foods are listed. (JL)

  20. The reflexive case study method

    DEFF Research Database (Denmark)

    Rittenhofer, Iris

    2015-01-01

    This paper extends the international business research on small to medium-sized enterprises (SME) at the nexus of globalization. Based on a conceptual synthesis across disciplines and theoretical perspectives, it offers management research a reflexive method for case study research of postnational...

  1. Overview of the Case Studies

    DEFF Research Database (Denmark)

    Cameron, Ian; Gani, Rafiqul

    2011-01-01

    A series of case studies are used to illustrate many of the underlying modelling principles within the book. To facilitate this, the ICAS-MoT modelling tool has been used. A wide range of application areas have been chosen to ensure that the principal concepts of effective and efficient modelling...

  2. Equatorial jet - a case study

    Digital Repository Service at National Institute of Oceanography (India)

    Muraleedharan, P.M.; PrasannaKumar, S.

    Detailed EOF analysis of wind data reportEd. by Wunsch over Gan (00 degrees 41'S; 73 degrees 10'E) is made for the period 1963-70. The year 1964, which exhibited least variability from mean wind structure, has been chosen for the case study. EOF...

  3. Herniation of the cerebellar tonsils after suprasellar arachnoid cyst shunt: case report Herniação das tonsilas cerebelares após shunt de cisto aracnóide supra-selar: relato de caso

    Directory of Open Access Journals (Sweden)

    Rodrigo Mendonça

    2006-06-01

    Full Text Available It is known that the caudal dislocation of the cerebellar tonsils may occur associated with clinical conditions such as an intracranial mass lesion or Chiari I and II malformation. It may also be acquired after repeated lumbar punctures or lumboperitoneostomy. The occurrence of cerebellar herniation after derivation of intracranial arachnoid cyst is extremely rare, and there are only three cases reported in the medical literature. We present the case of a 9-year-old boy with precocious puberty and suprasellar arachnoid cyst who developed a symptomatic herniation of the cerebellar tonsils three years after a cystoperitoneostomy. The patient underwent a suboccipital craniectomy with duraplasty and partial tonsilectomy, showing afterwards, remission of the symptoms. We discussed the pathogenesis suggested in the literature.Sabe-se que o deslocamento caudal das tonsilas cerebelares pode ocorrer em associação com condições clínicas tais como: lesão expansiva intracraniana ou malformação de Chiari I e II. Pode ainda ser adquirido após repetidas punções lombares ou lomboperitoniostomia. A ocorrência de herniação cerebelar após derivação de cisto aracnóide intracraniano é evento extremamente raro, existindo apenas três casos relatados na literatura médica. O caso de menino de 9 anos de idade, com puberdade precoce e cisto aracnóide supra-selar, que desenvolveu herniação sintomática das tonsilas cerebelares três anos após cistoperitoniostomia. O paciente foi submetido a craniectomia suboccipital com plástica dural e tonsilectomia parcial, apresentando remissão dos sintomas. Discutimos a patogênese sugerida na literatura.

  4. AP1000核电厂应对全厂断电事故的稳压器防满溢对策研究%AP1000 Plant Pressurizer Overfilling Prevention Study Against Station Blackout Accident

    Institute of Scientific and Technical Information of China (English)

    刘展; 王喆; 张国胜; 秦慧敏

    2014-01-01

    If loss of main feed-water occurs in a station blackout accident for AP1000 plant ,the pressurizer will overfill and the coolant will be discharged through pressurizer safety valves .It results in a loss of coolant accident ,RCS inventory will decrease ,and the risk of reactor core uncovering increases .Because of the coolant discharging , the atmosphere radiation level in the containment may be raised , w hile the possibility of radioactive release to the environment increases .In order to prevent pressurizer overfill-ing ,an effective strategy to avoid and mitigate pressurizer overfilling was provided .The results show that increasing heat transfer areas of PRHRS heat exchanger can prevent pressurizer overfilling ;reasonable decreasing of IRWST back pressure can enhance mar-gins of pressurizer overfilling , and mitigate pressurizer overfilling phenomena ;increasing pressurizer volumes can also avoid pressurizer overfilling . T he conclusions have reference value in helping design and safety analysis of AP 1000 plant .%A P1000核电厂若在全厂断电事故下丧失正常给水,会引起稳压器满溢,将通过稳压器安全阀排放液体冷却剂,引起反应堆冷却剂水装量流失,增大反应堆堆芯裸露的风险。与此同时,安全壳内的放射性水平因稳压器满溢可能会增大,增大向环境排放大量放射物质的可能。为防止稳压器满溢,本工作进行了解决或缓解稳压器满溢的对策研究。结果表明,增大非能动余热排出系统(PRHRS )热交换器的传热面积,可防止稳压器满溢;合理降低安全壳内置换料水箱(IRWST )的背压,可增大达到稳压器满溢的裕度,有效地缓解稳压器满溢;增大稳压器的自由容积,可防止稳压器满溢。此结论对A P1000核电厂的设计和事故分析有一定的参考作用。

  5. CGM ApS Årsberetning til DANAK

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2003. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, ErhvervsfremmeStyrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler.......Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2003. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, ErhvervsfremmeStyrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler....

  6. A cross sectional study of satisfaction of in-patients in a private medical college hospital in A.P

    Directory of Open Access Journals (Sweden)

    Rajagopal Rao Kodali

    2011-01-01

    Full Text Available Objectives: To study the level of satisfaction of in-patients and to find out the causes for dissatisfaction. Materials and Methods : Study area - Pinnamaneni Siddhartha General Hospital.Study population: In-patients admitted in the Medicine, Surgery, Obstetrics and Gynecology, Orthopedics wards. Sample size: 200. Study Design: A well designed cross-sectional study using pre tested structural pro forma. Duration of study: 2 Months. Survey method: The sample size is randomly selected. Respondent is the patient. Patient satisfaction was assessed in relation to doctors, nurses, housekeeping and billing. The satisfactory levels were divided into Very good, Good, Fair, Bad, and Very bad. Results: The satisfaction of in-patients expressed by majority was Good followed by Fair, Bad, Very good, and Very bad. The satisfaction expressed was more with nursing services followed by doctors and billing and least with housekeeping.

  7. A case study of Impetigo

    Directory of Open Access Journals (Sweden)

    Mansouri P

    1993-05-01

    Full Text Available This is a report of a case study on 234 patients with impetigo who referred to Razi Dermatology Hospital from April to November, 1989. Treatment was started immediately after obtaining direct smear and performing culture and antibiotic sensitivity test. The most common organism responsible for impetigo was the coagulase-positive staphylococcus (71%. In 13.7% of the cases, the coagulase-negative staphylococcus was grown on culture media, but none of the cultures showed streptococcus as the main organism. Treatment was started with oral penicillin V, oral erythromycin, benzathine penicillin G injection, oral cephalexin, and topical fuccidin. Clinical and bacteriological evaluation after 3-7 days showed that it is preferable to use oral cephalexin instead of other protocols such as oral erythromycin, which has previously been the drug of choice for impetigo. In addition, topical fuccidin with a 75% curative rate was the first drug for treatment, with the same effect as the oral cephalexin

  8. A eletromiografia como auxílio na conduta terapêutica após cirurgia de craniotomia fronto-temporal: relato de caso Electromyography as an aid in therapeutic behavior after fronto-temporal craniotomy surgery: case report

    Directory of Open Access Journals (Sweden)

    Maristella Cecco Oncins

    2009-01-01

    Full Text Available TEMA: eletromiografia e conduta terapêutica. PROCEDIMENTOS: este estudo foi realizado com uma paciente de 45 anos de idade, após 4 meses ser submetida a craniotomia fronto-temporal proveniente de um aneurisma. O músculo temporal anterior direito foi retirado da sua origem móvel e após a cirurgia, a paciente apresentou disfunção do músculo temporal e da articulação temporomandibular, com redução da abertura de boca, dor ao falar e comer. Utilizou-se a eletromiografia para registrar quantitativamente a atividade elétrica dos músculos temporais e masseteres na avaliação e durante o processo terapêutico. Registraram-se, na posição de repouso, oclusão máxima e mastigação habitual provocada. Fez-se terapia miofuncional durante todo o processo. RESULTADOS: dados dos exames mostraram um aumento significativo da atividade elétrica do músculo temporal anterior direito e uma redução da atividade do músculo temporal anterior esquerdo, o que no primeiro registro mostrava uma atividade elétrica rebaixada do lado direito em comparação com o lado esquerdo. Com a seleção dos exercícios miofuncionais houve uma participação mais efetiva do músculo temporal anterior direito, abertura de boca maior, sem dor, facilitando a função da mastigação e da fala, harmonizando o sistema estomatognático. CONCLUSÃO: registros comparativos dos exames de eletromiografia em diferentes etapas do processo terapêutico auxiliaram e direcionaram a melhor conduta terapêutica fonoaudiológica. Conseguiu-se atingir um equilíbrio das funções de respiração, sucção, mastigação, deglutição e fala relacionadas ao sistema estomatognático, considerando as limitações do caso.BACKGROUND: electromyography and therapeutic behavior. PROCEDURES: this study was carried out with a woman, 45year old, after 4 months from being submitted to fronto-temporal craniotomy originated an aneurysm. The right anterior temporal muscle was removed from its

  9. 3D-AP and positron annihilation study of precipitation behavior in Cu-Cr-Zr alloy

    DEFF Research Database (Denmark)

    Hatakeyama, M.; Toyama, T.; Yang, J.;

    2009-01-01

    Precipitation behavior in a Cu-0.78%Cr-0.13%Zr alloy during aging and reaging has been studied by laser-assisted local electrode three-dimensional atom probe (Laser-LEAP) and positron annihilation spectroscopy (PAS). After the prime aging at 460 degrees C, Cr clusters enriched with Zr were observ...

  10. Computer Based Training - A Report of a NATO Study Visit to America. A.P. Report 91.

    Science.gov (United States)

    Patrick, J.

    This report describes some of the research projects encountered on a 1979 study visit which investigated the nature and availability of computer-based training (CBT) systems in the United States and Canada, particularly within industrial, occupational and military contexts. An overview of the trip itinerary includes the names of the organizations…

  11. Center for Geometrisk Metrologi, CGM ApS

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2002. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, Erhvervsfremme Styrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler (Teknisk Forskrift Nr. TF4 af 2000...

  12. Enfisema subcutâneo e pneumomediastino após amigdalectomia: relato de caso Onset of subcutaneous emphysema and pneumomediastinum after tonsillectomy: a case report

    Directory of Open Access Journals (Sweden)

    Ângelo C. D. Panerari

    2005-02-01

    Full Text Available Várias complicações podem estar relacionadas a procedimentos cirúrgicos na área de cabeça e pescoço. Entre elas, o pneumomediastino, pneumotórax e enfisema subcutâneo ocorrem raramente. Relatamos o caso de uma paciente submetida a tonsilectomia palatina que evoluiu com enfisema subcutâneo da região cervical, torácica e pneumomediastino. Em cirurgias de tonsilas palatinas devem ser observados cuidados com a intubação, uso de máscara sob pressão positiva com oxigênio na recuperação anestésica, atos cirúrgicos intempestivos e uso de aparelhos que proporcionem lesão excessiva na loja tonsiliana a fim de se evitar as complicações descritas.Several complications can be related to surgical approaches of head and neck regions. Among those, there are rare conditions such as pneumomediastinum, pneumothorax and subcutaneous cervical emphysema. This study reports a case of a patient that developed pneumomediastinum, pneumothorax and subcutaneous emphysema after undergoing tonsillectomy. In order to reduce these complications in surgical approaches such as tonsillectomy, care should be taken with intubation, use of oxygen mask for positive pressure ventilation during anesthesia recovery, aggressive surgical maneuvers and use of surgical instruments that may cause deep tonsillar injuries.

  13. TEACHER BELIEFS: A CASE STUDY

    Institute of Scientific and Technical Information of China (English)

    HuYijie

    2004-01-01

    In recent years ELT has stressed the role which teachers' beliefs play in shaping what they do in the classroom. But so far as teaching English in China is concerned, we lack empirical insight into the relationship between teachers' beliefs and their classroom practice. With specific reference to the use of English in intensive reading classes, by presenting and discussing data from a case study of a non-native college English teacher,this exploratory qualitative classroom research sheds light on the nature of teachers' beliefs held consciously or unconsciously.Their subsequent change and impact on the classroom will also be reported and discussed.

  14. Multiplicity of rapidly oscillating Ap stars

    CERN Document Server

    Schoeller, M; Hubrig, S; Kurtz, D W

    2012-01-01

    Rapidly oscillating Ap (roAp) stars have rarely been found in binary or higher order multiple systems. This might have implications for their origin. We intend to study the multiplicity of this type of chemically peculiar stars, looking for visual companions in the range of angular separation between 0.05" and 8". We carried out a survey of 28 roAp stars using diffraction-limited near-infrared imaging with NAOS-CONICA at the VLT. Additionally, we observed three non-oscillating magnetic Ap stars. We detected a total of six companion candidates with low chance projection probabilities. Four of these are new detections, the other two are confirmations. An additional 39 companion candidates are very likely chance projections. We also found one binary system among the non-oscillating magnetic Ap stars. The detected companion candidates have apparent K magnitudes between 6.8 and 19.5 and angular separations ranging from 0.23" to 8.9", corresponding to linear projected separations of 30-2400AU. While our study confi...

  15. 统一螺纹量规标准研究及其在AP1000反应堆压力容器主螺栓制造中的应用%Study on Standard of Gages for Unified Screw Threads and Application on AP1000 Reactor Pressure Vessel Main Stud Manufacturing

    Institute of Scientific and Technical Information of China (English)

    易飞; 杨杰

    2015-01-01

    研究了按ASME B1. 2标准规定的统一螺纹量规(通、 止规)的设计原则, 介绍了统一螺纹量规功能、 公差设置、 量规尺寸确定等, 并针对AP1000反应堆压力容器主螺栓螺纹制造和检测提出建议, 为业内及其他统一螺纹制造和检测提供参考.%This paper studies the design principles, function and determination of tolerances and dimensions of gages for unified inch screw thread according to ASME B1. 2 standard, based on which some suggestions are given for AP1000 reactor pressure vessel main studs manufacturing and testing, as reference for in industry sectors.

  16. Physiologic amputation: a case study.

    Science.gov (United States)

    Long, Jeri; Hall, Virginia

    2014-03-01

    Acute limb ischemia is a complication of severe peripheral arterial disease that can be a threatening limb as well as life. Multiple procedures exist today to help revascularize extremities; however, even with the latest technologies, surgical amputation of the limb may still be necessary. Cryoamputation, or physiologic amputation, is a method used to treat patients who are hemodynamically unstable for the operating room and who are in need of urgent amputation owing to arterial ischemia. This procedure is used in the rare instance where not only a persons' limb is threatened, but also their life. This is a case study regarding one patient who presented to the hospital with limb-threatening ischemia who became hemodynamically unstable owing to the rhabdomyolysis associated with the ischemia of his lower extremity. Cryoamputation was used to stabilize the patient and prevent further deterioration, so that he could safely undergo surgical amputation of the limb without an increase in mortality risk. Cryoamputation must be followed by formal surgical amputation when the patient is hemodynamically stabilized. It is not a limb salvaging, procedure but it is a life-saving procedure. This case study demonstrates the usefulness of the procedure and discusses the technique used for cryoamputation.

  17. Five misunderstandings about Case-study Research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...

  18. Five misunderstandings about case study research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2004-01-01

    This article examines five common misunderstandings about case-study research: (1) Theoretical knowledge is more valuable than practical knowledge; (2) One cannot generalize from a single case, therefore the single case study cannot contribute to scientific development; (3) The case study is most...

  19. Using Correspondence Analysis in Multiple Case Studies

    NARCIS (Netherlands)

    Kienstra, Natascha; van der Heijden, Peter G.M.

    2015-01-01

    In qualitative research of multiple case studies, Miles and Huberman proposed to summarize the separate cases in a so-called meta-matrix that consists of cases by variables. Yin discusses cross-case synthesis to study this matrix. We propose correspondence analysis (CA) as a useful tool to study thi

  20. Using correspondence analysis in multiple case studies

    NARCIS (Netherlands)

    Kienstra, N.H.H.; van der Heijden, P.G.M.

    2015-01-01

    In qualitative research of multiple case studies, Miles and Huberman proposed to summarize the separate cases in a so-called meta-matrix that consists of cases by variables. Yin discusses cross-case synthesis to study this matrix. We propose correspondence analysis (CA) as a useful tool to study thi

  1. Edema pulmonar por pressão negativa após extubação traqueal: relato de caso Negative pressure pulmonary edema after tracheal extubation: case report

    Directory of Open Access Journals (Sweden)

    Fabiano Timbó Barbosa

    2007-03-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O edema pulmonar por pressão negativa após obstrução de via aérea é atualmente uma entidade bem descrita, porém pouco diagnosticada e com poucos casos relatados. O objetivo deste artigo foi relatar um caso de edema pulmonar por pressão negativa (EPPN após extubação traqueal com sucesso terapêutico, após uso de ventilação mecânica não-invasiva com pressão positiva. RELATO DO CASO: Paciente do sexo feminino, 22 anos, foi submetida à colecistectomia aberta. Os exames pré-operatórios encontravam-se sem alterações. Imediatamente após extubação a paciente apresentou dispnéia súbita e crepitações pulmonares. Foi iniciado tratamento para edema agudo de pulmão com oxigenoterapia sob máscara de Venturi, elevação do tórax e diurético. A paciente foi encaminhada a UTI devido a falha no tratamento. Ao chegar a UTI foi iniciada ventilação mecânica não-invasiva (VMNI com pressão de suporte (15 cmH2O e pressão expiratória final positiva (5 cmH2O com resolução dos sintomas. A paciente foi mantida em observação por mais 24 horas depois do evento com boas condições e recebeu alta para o quarto sem sintomas. CONCLUSÕES: O EPPN é uma entidade de difícil diagnóstico e deverá ser observada sempre que os pacientes evoluem com sinais e sintomas de insuficiência respiratória pós-extubação. Esta paciente se beneficiou de VMNI, mas caso haja falha terapêutica, a intubação traqueal e o suporte ventilatório mecânico invasivo deverão ser instituídos para melhor oxigenação dos pacientes.BACKGROUND AND OBJECTIVES: Negative pressure pulmonary edema after acute upper airway obstruction is a well-described event, thought infrequently diagnosed and reported. This report aimed at presenting a case of postextubation negative pressure pulmonary edema refractory to use of diuretics and with successful therapeutic after using positive pressure noninvasive mechanic ventilation. CASE REPORT: A

  2. Learning about Antiphospholipid Syndrome (APS)

    Science.gov (United States)

    ... other autoimmune disorders, including myasthenia gravis, Graves' disease, autoimmune hemolytic anemia, and Evan's syndrome. Top of page How is APS diagnosed? A diagnosis of APS is made based on both clinical and ... Autoimmune Related Diseases Association, Inc. [aarda.org] An organization ...

  3. Proximal femoral canal shape is more accurately assessed on AP hip radiographs than AP pelvis radiographs in primary hip osteoarthritis.

    Science.gov (United States)

    Merle, Christian; Waldstein, Wenzel; Gregory, Jennifer S; Goodyear, Simon R; Aspden, Richard M; Aldinger, Peter R; Murray, David W; Gill, Harinderjit S

    2013-01-01

    The objectives of the present study were to determine whether differences in the radiographic appearance of the of the proximal femoral canal exist on corresponding AP pelvis and AP hip radiographs, and whether radiographic assessment of canal shape is accurate with reference to computed tomography (CT). In a retrospective study, corresponding radiographs and CT scans of 100 consecutive patients with primary hip OA were evaluated. Active shape modelling (ASM) was performed to assess the variation in proximal femoral canal shape and to identify differences between AP hip and AP pelvis views. Differences in the medial cortical flare between radiographs and CT were quantified using least squares curve fitting. ASM identified significant differences in the assessment of canal shape on corresponding AP hip and AP pelvis views. Curve fitting demonstrated a good agreement between AP hip radiographs and CT. Agreement between AP pelvis radiographs and CT was less good. In contrast to AP pelvis radiographs, AP hip radiographs allow a more accurate and reliable assessment of proximal femoral canal shape in the frontal plane in primary hip OA. Our findings may improve stem fit in total hip arthroplasty without the routine use of CT.

  4. Comparative analysis between radiographic views for knee osteoarthrosis (bipedal AP versus monopedal AP

    Directory of Open Access Journals (Sweden)

    Rodrigo Pires e Albuquerque

    2013-08-01

    Full Text Available OBJECTIVE: A comparative analysis by applying the criteria of the original classification Ahlbäck in the anteroposterior (AP bipedal knee in extension and anteroposterior (AP monopodal knee in symptomatic knee arthrosis. With this analysis we intend to observe the agreement, any advantage or difference between the incidence and degree of joint involvement between the orthopedic surgeons and radiologists with the referring physician. METHODS: From January 2012 to March 2012, was a prospective study of 60 symptomatic arthrosis knees (60 patients, clinically selected group of outpatient knee and radiographic proposals submitted to the search. Of the 60 patients, 39 were female and 21 male, mean age 64 years (ranging from 50 to 84 years. Of the 60 knees studied, 37 corresponded to the right side and 23 on the left side. Statistical analysis was performed by Kappa statistics, which evaluates the interobserver agreement for qualitative data. RESULTS: According to the scale of Ahlbäck, there was a significant agreement (p < 0.0001 intra-observer in the classification of knee osteoarthritis among the five evaluators. There was a significant agreement (p < 0.0001 with inter-observer referring physician in the incidence of AP monopodal and AP bipedal for the four raters. CONCLUSION: The study found no difference between the incidence in the AP monopodal versus AP bipedal in osteoarthritis of the knee.

  5. Case Study: A Picture Worth a Thousand Words? Making a Case for Video Case Studies

    Science.gov (United States)

    Pai, Aditi

    2014-01-01

    A picture, they say, is worth a thousand words. If a mere picture is worth a thousand words, how much more are "moving pictures" or videos worth? The author poses this not merely as a rhetorical question, but because she wishes to make a case for using videos in the traditional case study method. She recommends four main approaches of…

  6. KAIZEN – A case study

    Directory of Open Access Journals (Sweden)

    Manjunath Shettar

    2015-05-01

    Full Text Available The ultimate objective of manufacturing industries is to increase productivity with high quality. At present, many manufacturing companies are facing problems such as high quality rejection, high inventories, high lead time, high costs of production, and inability to cope with customer orders. By implementing and practicing the lean production system many problems can be solved without employing high-tech and high-touch approaches but by involving people on the shop floor in Kaizen activities. Kaizen is one of the powerful tools of lean manufacturing. Kaizen refers to continuous improvement in performance, cost and quality. Kaizen ensures that manufacturing processes become leaner and fitter, but eliminate waste (problem where value is added. The main objective of this paper is to provide a background on kaizen, present an overview of kaizen concepts that are used to transform a company into a high performing lean enterprise. A case study of implementation of Kaizen‟s has been discussed.

  7. STS Case Study Development Support

    Science.gov (United States)

    Rosa de Jesus, Dan A.; Johnson, Grace K.

    2013-01-01

    The Shuttle Case Study Collection (SCSC) has been developed using lessons learned documented by NASA engineers, analysts, and contractors. The SCSC provides educators with a new tool to teach real-world engineering processes with the goal of providing unique educational materials that enhance critical thinking, decision-making and problem-solving skills. During this third phase of the project, responsibilities included: the revision of the Hyper Text Markup Language (HTML) source code to ensure all pages follow World Wide Web Consortium (W3C) standards, and the addition and edition of website content, including text, documents, and images. Basic HTML knowledge was required, as was basic knowledge of photo editing software, and training to learn how to use NASA's Content Management System for website design. The outcome of this project was its release to the public.

  8. Using teaching case studies for management research

    OpenAIRE

    Ambrosini, Veronique; Bowman, Cliff; Collier, Nardine

    2010-01-01

    Teaching case studies are widely deployed in business schools. They are contextually rich in detail, and students learn by applying and adapting theoretical concepts to specific business situations described in the case. This article proposes a new way to use teaching case studies, as research materials for academics. The article addresses three questions: (1) Can teaching cases be used as an alternative to field research? (2) When can teaching case studies be used as second...

  9. Value of case studies in disaster assessment?

    Science.gov (United States)

    Grynszpan, Delphine; Murray, Virginia; Llosa, Silvia

    2011-06-01

    Case studies can be useful in assessing and learning lessons from emergency situations. In this paper, different uses for disaster case studies, are explored with identification of potential pitfalls that should be avoided. In addition, ways to improve the rigor and significance of case studies are suggested. Case studies can be used as examples or as a research tool. If conducted properly, they can provide robust and compelling results. It is argued that sharing a common guide to conducting and writing case studies among all disaster risk reduction professionals could improve the quality of case study reports and thereby strengthen their value in advancing the prevention, preparedness, and management of disasters and emergencies.

  10. Fístula Arteriovenosa após Nefrectomia Radical: A Propósito de um Caso Clínico Arteriovenous fistula after Radical Nephrectomy:: a case report

    Directory of Open Access Journals (Sweden)

    Nádia Duarte

    2011-09-01

    Full Text Available Existem três tipos diferentes de fístulas arteriovenosas (FAV renais, as congénitas, as idiopáticas e as adquiridas, sendo as últimas as mais frequentes. Dentro destas, as resultantes da nefrectomia são uma raridade. A FAV entre a artéria renal e a veia cava inferior (VCI é uma complicação rara após nefrectomia, estando descritos cerca de 10 casos na literatura. Os autores descrevem um caso de um homem de 51 anos, insuficiente renal crónico (IRC em hemodiálise, enviado à consulta de Urologia por nódulo sólido do rim direito sugestivo de neoplasia, detectado em ressonância magnética (RMN. Foi submetido a nefrectomia radical direita, tendo sido efectuada laqueação conjunta do pedículo renal, sem intercorrências cirúrgicas. Quatro meses depois, inicia clínica de sobrecarga hídrica, de difícil controlo com a hemodiálise e surge um sopro abdominal localizado no flanco direito, contínuo. O estudo por eco-doppler abdominal e angiografia demonstrou a presença de fístula entre a artéria renal e a veia cava inferior. Foi submetido a embolização da FAV com coils, tendo-se registado migração dos mesmos para a artéria pulmonar. A sua recolha foi efectuada imediatamente com basket, sem outras intercorrências. Posteriormente, foi submetido a laparotomia com laqueação simples da artéria renal justa-aórtica, com resolução e estabilização do quadro clínico. A propósito deste caso clínico os autores discutem a abordagem diagnóstica e a hierarquia terapêutica da FAV reno-VCI nomeadamente na cirurgia directa e endovascular.There are three different types of renal arteriovenous fistula (AVF, congenital, idiopathic and acquired, being the latter the most frequent. Within these, those resulting from nephrectomy are rare. The AVF between the renal artery and the inferior vena cava (IVC is a rare complication, with about 10 cases described in literature. The authors describe the case of a 51 year old man, with chronic

  11. APS Editorial Q&A: APS and Open Access

    Science.gov (United States)

    2011-04-01

    The movement toward Open Access continues to gain momentum. A brief review of APS efforts in this area will be presented by APS Editor in Chief, Gene Sprouse. Editors from Physical Review C, D, Letters, and X, Physical Review Special Topics - Accelerators and Beams, Physical Review Special Topics - Physics Education Research, and Reviews of Modern Physics will address your questions about publishing in this evolving environment.

  12. Structuring the AP Art History Course

    Science.gov (United States)

    Herscher, Walter R.

    2013-01-01

    While AP (Advanced Placement) Art History may be taught within the art department in many schools, social studies teachers are equally capable of teaching the course well. They have the historical background to discuss the reasons for changes in art styles. A teacher's preparation is similar to teaching a course stressing political history,…

  13. Catalog of NASA-Related Case Studies

    Data.gov (United States)

    National Aeronautics and Space Administration — The OCKO has developed over 50 case studies to enhance learning at workshops, training, retreats and conferences. Case studies make mission knowledge attractive and...

  14. Case Study: The Chemistry of Cocaine

    Science.gov (United States)

    Dewprashad, Brahmadeo

    2011-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's case study focuses on the chemistry of cocaine to teach a number of core concepts in organic chemistry. It also requires that students read and analyze an original research paper on…

  15. Writing case studies in information systems research

    NARCIS (Netherlands)

    van der Blonk, H.C.

    2003-01-01

    Case study research can be reported in different ways. This paper explores the various ways in which researchers may choose to write down their case studies and then introduces a subsequent typology of writing case studies. The typology is based on a 2 x 2 matrix, resulting in four forms of writing

  16. Concentrated photovoltaics, a case study

    Directory of Open Access Journals (Sweden)

    Antonini Piergiorgio

    2014-01-01

    Full Text Available Concentrated Photovoltaics (CPV, once a niche technology, has now reached the maturity and reliability for large scale power generation. Especially in regions where temperatures are very high, the use of high efficiency triple junction solar cells with concentrating optics allows stable energy yield. Thus CPV can be seen as complementary and not in concurrence with silicon photovoltaics. The state of the art, the advantages and limitations of this technology will be shown. Among the main advantages of CPV is the possibility of a much higher energy supply, when compared to silicon photovoltaics, both comparing CPV and silicon with same area or the same installed power. The use of recycled and recyclable materials allows a more environmentally friendly production. The possibility to couple CPV with desalination facilities, energy storage will be analysed. As an example a case study of a CPV installation in Northern Italy is discussed. Here the use of mature technologies, derived from automotive and lighting sectors resulted in a simple and efficient module.

  17. Concentrated photovoltaics, a case study

    Science.gov (United States)

    Antonini, Piergiorgio; Centro, Sandro; Golfetto, Stelvio; Saccà, Alessandro

    2014-12-01

    Concentrated Photovoltaics (CPV), once a niche technology, has now reached the maturity and reliability for large scale power generation. Especially in regions where temperatures are very high, the use of high efficiency triple junction solar cells with concentrating optics allows stable energy yield. Thus CPV can be seen as complementary and not in concurrence with silicon photovoltaics. The state of the art, the advantages and limitations of this technology will be shown. Among the main advantages of CPV is the possibility of a much higher energy supply, when compared to silicon photovoltaics, both comparing CPV and silicon with same area or the same installed power. The use of recycled and recyclable materials allows a more environmentally friendly production. The possibility to couple CPV with desalination facilities, energy storage will be analysed. As an example a case study of a CPV installation in Northern Italy is discussed. Here the use of mature technologies, derived from automotive and lighting sectors resulted in a simple and efficient module.

  18. Pneumopericárdio após traumatismo penetrante: relato de três casos Pneumopericardium after penetrating trauma: report of three cases

    Directory of Open Access Journals (Sweden)

    Fernando Antonio Campelo Spencer Netto

    2001-12-01

    Full Text Available Pneumopericardium after penetrating wound represents a high suspicion for cardiac wound. Some authors recommend thoracotomy to discharge a cardiac lesion. We present three cases of post-traumatic pneumopericardium one following a gunshot wound and two following a stab wound and discuss about diagnosis and treatment. None showed clinical signs of cardiac tamponade. Diagnosis was made by chest x-ray. Pneumopericardium was identified at the initial evaluation in two patients, who had concomitant hemothorax and underwent chest drainage. The patient with penetrating thoracic wound by gunshot pneumopericardium developed 24h after trauma. Treatment was directed to the associated lesions without specific measurements for pneumopericardium. This aproach was safe in these patients.

  19. Remissão espontânea de um granuloma eosinofílico orbitário após biópsia: relato de caso e revisão da literatura Spontaneous remission of an orbital eosinophilic granuloma after biopsy: a case report and literature review

    Directory of Open Access Journals (Sweden)

    Jayter Silva de Paula

    2003-08-01

    Full Text Available OBJETIVO: Relatar o caso de paciente de 17 anos de idade com granuloma eosinofílico (GE na parede superior da órbita com regressão espontânea após biópsia. MÉTODOS: Relato de caso. RESULTADOS: Remissão espontânea após biópsia incisional, via palpebral, de lesão de teto orbitário, sem evidências clínicas e tomográficas de recorrência com seguimento de 22 meses. A análise histopatológica da biópsia confirmou granuloma de aspecto proliferativo apresentando macrófagos, eosinófilos e células de Langerhans sem características neoplásicas. CONCLUSÃO: A remissão espontânea do caso descrito levanta a hipótese de que seguimento cuidadoso de pacientes com GE orbitário, confirmado por biópsia incisional, com exames de controle rotineiros, pode ser uma maneira menos invasiva e eficaz de abordagem.PURPOSE: To report a case of a 17-year-old patient who presented with spontaneuos remission of an eosinophilic granuloma (EG of the superior orbital wall after biopsy. METHODS: Case report. RESULTS: An orbital roof lesion was biopsied through lid crease approach. The histopathological study showed a granuloma with a proliferative aspect with macrophages, eosinophils and Langerhans' cells, without neoplastic features. After biopsy there was spontaneous remission demonstrated by computerized tomography scans of the orbit on a 22-month follow-up period. CONCLUSION: This case highlights that spontaneous remission of unifocal eosinophilic granuloma should be considered in the management of these lesions.

  20. Pseudoaneurisma de artéria genicular após cirurgia artroscópica de joelho: Relato de dois casos Geniculate artery pseudoaneurysm after arthroscopic knee surgery: Two case reports

    Directory of Open Access Journals (Sweden)

    Edgard dos Santos Pereira Junior

    2010-01-01

    Full Text Available A artroscopia do joelho é considerado um procedimento cirúrgico muito seguro, com um número relativamente pequeno de complicações. Relatamos o caso de dois pacientes do sexo masculino que foram submetidos à artroscopia de joelho (para meniscectomia parcial e reconstrução do ligamento cruzado anterior com parafuso transverso femoral e interferência tibial que desenvolveram um pseudoaneurisma de artéria genicular superior lateral após o procedimento. A ultrassonografia com Doppler realizou o diagnóstico e os pacientes foram tratados cirurgicamente com ligadura arterial. Um paciente apresentou extenso hematoma na coxa e foi necessária reposição volêmica. Estes casos exemplificam uma complicação vascular rara, nem sempre benigna, em uma cirurgia minimamente invasiva do joelho.Arthroscopy of the knee is a very safe surgical procedure, with relatively few complications. Here we present the cases of two patients submitted to arthroscopic surgery for partial meniscectomy and reconstruction of the anterior cruciate ligament with femoral transverse screw and tibial interference screw that developed a superior lateral genicular artery pseudoaneurysm. Doppler ultrasonography was performed for diagnostic purposes and the patients were treated by direct arterial suture. One patient developed a large haematoma requiring volemic replacement. These cases illustrate a rare, and not always benign vascular complication, in a minimally invasive arthroscopic surgery.

  1. Demystifying Instructional Innovation: The Case of Teaching with Case Studies

    Science.gov (United States)

    Kantar, Lina D.

    2013-01-01

    Issues emerging from instructional innovation are inevitable, yet basing any curriculum shift on a theoretical framework is paramount. This paper grounds the case-based pedagogy in three learning theories: behaviorism, cognitivism, and constructivism. The three theories are described and situated in relation to the case study method. An…

  2. Enfisema orbitário compressivo após asseio nasal: relato de caso Sight-threatening orbital emphysema after nose blowing: case report

    Directory of Open Access Journals (Sweden)

    Bruno de Albuquerque Furlani

    2009-04-01

    Full Text Available O enfisema orbitário é caracterizado pela presença anormal de ar na órbita. Sua ocorrência espontânea não é frequente e a maioria dos casos está associada à fratura de órbita. Relatamos o caso de uma paciente do sexo feminino de 40 anos com quadro de enfisema orbitário unilateral, secundário a asseio vigoroso do nariz. A paciente evoluiu com redução aguda da acuidade visual em decorrência de elevação da pressão intraocular, sendo indicado tratamento de urgência. Foi realizada punção orbitária com agulha 24-gauge próximo à região da incisura supraorbital, com melhora imediata do quadro clínico e recuperação da acuidade visual.Orbital emphysema is the abnormal presence of air in the orbit. Occurrence in the absence of orbital fracture is rare. We report a case of a 40-year-old female presenting unilateral orbital emphysema after vigorous nose blowing. She developed sudden visual loss as a result of elevated intraocular pressure and urgent treatment was required. She underwent an orbital decompression, performed using a 24-gauge needle puncture adjacent to the supraorbital notch. After treatment, she reported considerable decrease of symptoms.

  3. Background: GIS Applications and Case Studies

    OpenAIRE

    01, CCTP; Albert, Don

    1998-01-01

    This unit presents (1) a case study and (2) a bibliographic resource for GIS in the medical field. The case study illustrates the use of a GIS to monitor and analyze spatial patterns of physicians' multiple locations. This case highlights data location, acquisition and assessment, join and relational operators, geocoding and distance calculations, and standard query language.

  4. Study of factors controlling exposure dose and image quality of C-arm in operation room according to detector size of it (Mainly L-Spine AP study)

    Energy Technology Data Exchange (ETDEWEB)

    Chui, Sung Hyun; Jo, Hwang Woo [Dept. of Radiology, Kyung Hee University Hospital at Gangdong, Seoul (Korea, Republic of); Chun, Woon Kwan; Song, Ha Jin [Dept. of Nuclear Engineering, Chosun University, Gwangju (Korea, Republic of); Dong, Kyung Rae [Dept. of Radiological Technology, Gwangju Health University, Gwangju (Korea, Republic of); Choi, Eun Jin [Dept. of Public Health and Medicine, Dongshin University, Naju (Korea, Republic of)

    2015-02-15

    Time of operation has been reduced and accuracy of operation has been improved since C-arm, which offer real-time image of patient, was introduced in operation room. However, because of the contamination of patient, C-arm could not be used more appropriately. Therefore, this study is to know factors of controlling exposure dose, image quality and the exposed dose of health professional in operation room. Height of Wilson frame (bed for operation) was fixed at 130 cm. Then, Model 76-2 Phantom, which was set by assembling manual of Fluke Company, was set on the bed. Head/Spine Fluoroscopy AEC mode was set for exposure condition. According to detector size of C-arm, the absorbed dose per min was measured in the 7 steps OFD (cm) from 10 cm to 40 cm (10, 15, 20, 25, 30, 35, 40 cm). In each step of OFD, the absorbed dose per min of same diameter of collimation was measured. Moreover, using Nero MAX Model 8000, exposure dose per min was measured according to 3 step of distance from detector (20 cm, 60 cm, 100 cm). Finally, resolution was measured by CDRH Disc Phantom and magnification of each OFD was measured by aluminum stick bar. According to detector size of C-arm, difference of absorbed dose shows that the dose of 20 cm OFD is 1.750 times higher than the dose of 40 cm OFD. It means that the C-arm, which has smaller size of detector, shows the bigger difference of absorbed dose per min (p<0.05). In the difference of absorbed dose in the same step of OFD (from 20 cm to 40 cm), the absorbed dose of 9 inch detect or C-arm was 1.370 times higher than 12 inch' s (p<0.05). When OFD was set to 20 cm OFD, the absorbed dose of non-collimation case was approximately 0.816 times lower than the absorbed dose of collimation cases (p<0.05). When the distance was 20 cm from detector, exposed does includes first-ray and scatter-ray. When the distance was 60 cm and 100 cm from detector, exposed does includes just scatter-ray. So, there was the 2.200 times difference of absorbed

  5. Drive Electric Vermont Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Fred [Energetics Incorporated, Columbia, MD (United States); Roberts, Dave [Vermont Energy Investment Corporation (VEIC), Burlington, VT (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States); White, Sera [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Currently in the United States, the heavy majority of plug-in electric vehicle (PEV) sales have been in highly conducive, selected, metropolitan areas; opposed to more broad distribution across the country. The U.S. Department of Energy’s EV Everywhere Grand Challenge is looking carefully at the barriers and opportunities that exist to enable small and midsize communities to partake in the PEV market and benefit from the economic and environmental advantages of PEVs. In order to gain insight into these challenges and barriers, DOE selected a success story (i.e., Drive Electric Vermont) as the subject of this case study, as the state of Vermont is tied with Detroit, Michigan in having the highest percentage of 2014 (most recent complete data) PEV registrations for cold weather U.S. cities and has seen more than a sixfold increase in charging stations over the last three years. The overall objective of this case study was to use the lessons learned from Drive Electric Vermont to determine what activities are most effective at encouraging acquisitions of PEVs and deployment of charging infrastructure in small to midsize communities, prioritizing and sequencing their implementation, identifying robust means for extrapolation, and applying this understanding to other small to midsize communities across the nation. The Drive Electric Vermont Program was formed in 2012 with a goal of increasing the use of electrified transportation in Vermont through policy development, education and outreach, and infrastructure development. The Drive Electric Vermont Program can be broadly broken into four components: (1) strategic planning/leadership, (2) stakeholder/partnership development, (3) education and outreach, and (4) incentives. The early phases of the program focused heavily on strategic planning, and stakeholder and partnership development, followed by a transition to education and outreach activities, charging infrastructure development, and grant and incentive programs

  6. Drive Electric Vermont Case Study

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Fred [Energetics Incorporated, Columbia, MD (United States); Roberts, Dave [Vermont Energy Investment Corporation (VEIC), Burlington, VT (United States); Francfort, Jim [Idaho National Lab. (INL), Idaho Falls, ID (United States); White, Sera [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    Currently in the United States, the heavy majority of plug-in electric vehicle (PEV) sales have been in highly conducive, selected, metropolitan areas; opposed to more broad distribution across the country. The U.S. Department of Energy’s EV Everywhere Grand Challenge is looking carefully at the barriers and opportunities that exist to enable small and midsize communities to partake in the PEV market and benefit from the economic and environmental advantages of PEVs. In order to gain insight into these challenges and barriers, DOE selected a success story (i.e., Drive Electric Vermont) as the subject of this case study, as the state of Vermont is tied with Detroit, Michigan in having the highest percentage of 2014 (most recent complete data) PEV registrations for cold weather U.S. cities and has seen more than a sixfold increase in charging stations over the last three years. The overall objective of this case study was to use the lessons learned from Drive Electric Vermont to determine what activities are most effective at encouraging acquisitions of PEVs and deployment of charging infrastructure in small to midsize communities, prioritizing and sequencing their implementation, identifying robust means for extrapolation, and applying this understanding to other small to midsize communities across the nation. The Drive Electric Vermont Program was formed in 2012 with a goal of increasing the use of electrified transportation in Vermont through policy development, education and outreach, and infrastructure development. The Drive Electric Vermont Program can be broadly broken into four components: (1) strategic planning/leadership, (2) stakeholder/partnership development, (3) education and outreach, and (4) incentives. The early phases of the program focused heavily on strategic planning, and stakeholder and partnership development, followed by a transition to education and outreach activities, charging infrastructure development, and grant and incentive programs

  7. [Apheresis in antiphospholipid syndrome (APS)].

    Science.gov (United States)

    De Silvestro, Giustina; Tison, Tiziana; Marson, Piero

    2012-01-01

    Antiphospholipid syndrome (APS) is a rare clinical disorder characterized by thromboembolic manifestations and/or obstetric complications. Along with the clinical symptoms and signs, serum antiphospholipid antibodies have to be detected. APS can be primary, i.e., without any concomitant disorders, or secondary to other autoimmune diseases, particularly systemic lupus erythematosus. Criteria for the diagnosis of APS have been clearly established. Hyperacute APS (or catastrophic antiphospholipid syndrome), often with a poor prognosis, must meet four criteria: involvement of three or more organs, rapid evolution of clinical manifestations, microangiopathic occlusion of small blood vessels at biopsy, and presence of antiphospholipid antibodies. The rationale for apheresis treatment is the removal of pathogenetic antibodies involved in the development of tissue damage. Our experience includes 23 patients, in particular 15 women treated for 19 pregnancies. According to the National Guidelines Program, the effectiveness of apheresis in catastrophic syndrome has a level of evidence of V/VI, with a strength of recommendation A; in highrisk pregnancy it has a level of evidence of V with a strength of recommendation B. It will be necessary to better define the prognosis of various categories of pregnant patients with APS, as well as useful laboratory parameters to monitor its clinical course and anticipate any complications of pregnancy.

  8. APS Education and Diversity Efforts

    Science.gov (United States)

    Prestridge, Katherine; Hodapp, Theodore

    2015-11-01

    American Physical Society (APS) has a wide range of education and diversity programs and activities, including programs that improve physics education, increase diversity, provide outreach to the public, and impact public policy. We present the latest programs spearheaded by the Committee on the Status of Women in Physics (CSWP), with highlights from other diversity and education efforts. The CSWP is working to increase the fraction of women in physics, understand and implement solutions for gender-specific issues, enhance professional development opportunities for women in physics, and remedy issues that impact gender inequality in physics. The Conferences for Undergraduate Women in Physics, Professional Skills Development Workshops, and our new Professional Skills program for students and postdocs are all working towards meeting these goals. The CSWP also has site visit and conversation visit programs, where department chairs request that the APS assess the climate for women in their departments or facilitate climate discussions. APS also has two significant programs to increase participation by underrepresented minorities (URM). The newest program, the APS National Mentoring Community, is working to provide mentoring to URM undergraduates, and the APS Bridge Program is an established effort that is dramatically increasing the number of URM PhDs in physics.

  9. Roadmaster Roading Contractors Case Study

    Directory of Open Access Journals (Sweden)

    Hazel Taylor

    1999-01-01

    Full Text Available Systems analysis students seldom experience the practical difficulties of the initial investigation into a client’s requirements. They get little chance to practice the skills they need to investigate complex and confused problem situations, or to appreciate the wider organizational issues that can impact on a situation. This teaching case is designed to give students the opportunity to practice and apply investigation skills and to challenge them to consider the wider work environment when considering possible solutions to a problem situation. The case is conducted as a role-play, with students acting as systems analysts and teaching staff role-playing the clients. The students develop a report analyzing the client’s situation based on the issues that arise during the interviews. Feed-back sessions focus on discussing how well the students applied various interviewing strategies previously covered in lectures, and on the wider organizational problems that could impact proposed information system solutions.

  10. 表现为皮肤大片瘀斑和坏死的抗磷脂抗体综合征%A case of antiphospholipid syndrome (APS) presenting with large areas of ecchymosisand necrosis on skin

    Institute of Scientific and Technical Information of China (English)

    夏济平; 许阳; 侯麦花; 张美华

    2012-01-01

    报告1例表现为皮肤大片瘀斑和坏死的抗磷脂抗体综合征.患者女性,42岁.双侧臀部及下肢大片瘀斑、坏死,血小板减少,抗核抗体、抗心磷脂抗体异常升高,补体降低.皮损组织病理示真皮血管有血栓存在.给予抗凝、血管扩张剂、糖皮质激素、免疫抑制剂和静脉注射用人免疫球蛋白等控制病情的同时,外科手术修复大片坏死皮肤.%A case of antiphospholipid syndrome (APS) presenting with large areas of ecchymosis and necrosis on skin is reported. A 42-year-old female suffered from skin ecchymosis and necrosis in buttocks and lower limbs with thrombocytope-nia, abnormal elevation of ANA and antiphospholipid antibodies (APL), and low complements. Histopathology revealed thrombosis of dermal and subcutaneous vessels. As treatment with anticoagulation, vasodilation, immunosuppressant, intravenous im-munoglobulin, the condition of the patient was changed successfully. And then the effective surgical treatment restored the large area of the necrotic skin.

  11. Associative visual agnosia: a case study.

    Science.gov (United States)

    Charnallet, A; Carbonnel, S; David, D; Moreaud, O

    2008-01-01

    We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study, an alternative account in the framework of (non abstractive) episodic models of memory.

  12. Study on Case Teaching of Financial Management

    Science.gov (United States)

    Che, Zhenghong; Che, Zhengmei

    2011-01-01

    Case teaching is an efficient teaching method of management. It plays an important role to enhance the students' ability to practice the theory. However, case teaching of financial management has not achieved the expected results. The paper aims to study the importance, characteristics and corresponding methods of case teaching method of financial…

  13. Associative Visual Agnosia: A Case Study

    OpenAIRE

    A. Charnallet; S. Carbonnel; David, D.; Moreaud, O.

    2008-01-01

    We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study [1], an alternative account in the framework of (non abstractive) episodic models of memory [4].

  14. Hematoma após anestesia peridural: tratamento conservador. Relato de caso Hematoma posterior a la anestesia peridural: tratamiento conservador. Relato de caso Hematoma after epidural anesthesia: conservative treatment. Case report

    Directory of Open Access Journals (Sweden)

    Edno Magalhães

    2007-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O hematoma associado à compressão espinhal após anestesia peridural é uma complicação neurológica grave, apesar da pequena incidência relatada (1:150.000. É um episódio agudo, e o tratamento tradicionalmente aplicado é a descompressão cirúrgica de urgência. Mais recentemente, em casos específicos, o tratamento com corticosteróide tem sido aplicado como alternativa, com boa recuperação neurológica. O objetivo deste relato foi expor um caso de hematoma peridural com tratamento conservador e recuperação neurológica completa. RELATO DO CASO: Paciente do sexo feminino, 34 anos, estado físico ASA I, sem qualquer histórico de coagulopatia ou terapia anticoagulante, submetida à anestesia peridural com punção única, em L2-L3, para tratamento cirúrgico de varizes nos membros inferiores. Oito horas após a anestesia regional, ela ainda apresentava bloqueio motor completo (escala de Bromage, redução das sensibilidades térmica e dolorosa abaixo do nível L3, hiperalgesia na região plantar esquerda, preservação dos reflexos tendinosos e ausência de dor lombar. A tomografia computadorizada revelou hematoma peridural em L2 com compressão do saco dural. Dez horas após a punção peridural não havia progressão dos sinais e sintomas neurológicos. Optou-se, então, pelo tratamento com metilprednisolona em infusão venosa contínua (5,3 mg.kg-1 na primeira hora e 1,4 mg.kg-1.h-1 nas 23 horas subseqüentes. Oito horas após o início do tratamento, a paciente recuperou as sensibilidades térmica e dolorosa, e houve regressão total do bloqueio motor. Na 12ª hora, deambulava e referia dor na ferida operatória. O hematoma peridural não foi visualizado em nova tomografia computadorizada na 14ª hora após o início do tratamento. A paciente recebeu alta hospitalar 86 horas depois do início do tratamento conservador, sem comprometimento neurológico. Uma tomografia computadorizada de controle, ap

  15. Liverpool Telecare Pilot: case studies

    Directory of Open Access Journals (Sweden)

    Nigel Barnes

    2006-09-01

    Full Text Available Telecare services use information and communications technology (ICT to support the provision of care to people in their own homes. This paper describes a pilot telecare service employed by Liverpool (UK City Council to support a sample of their frail and elderly social services users. The pilot has been running for over two years and has been deployed for 21 individuals in Liverpool. In this paper we present the pilot system and provide real example cases which help to illustrate the benefits of such a system.

  16. Expansion and Functional Divergence of AP2 Group Genes in Spermatophytes Determined by Molecular Evolution and Arabidopsis Mutant Analysis

    Directory of Open Access Journals (Sweden)

    Pengkai Wang

    2016-09-01

    Full Text Available The APETALA2 (AP2 genes represent the AP2 group within a large group of DNA-binding proteins called AP2/EREBP. The AP2 gene is functional and necessary for flower development, stem cell maintenance, and seed development, whereas the other members of AP2 group redundantly affect flowering time. Here we study the phylogeny of AP2 group genes in spermatophytes. Spermatophyte AP2 group genes can be classified into AP2 and TOE types, six clades, and we found that the AP2 group homologs in gymnosperms belong to the AP2 type, whereas TOE types are absent, which indicates the AP2 type gene are more ancient and TOE type was split out of AP2 type and losing the major function. In Brassicaceae, the expansion of AP2 and TOE type lead to the gene number of AP2 group were up to six. Purifying selection appears to have been the primary driving force of spermatophyte AP2 group evolution, although positive selection occurred in the AP2 clade. The transition from exon to intron of AtAP2 in Arabidopsis mutant leads to the loss of gene function and the same situation was found in AtTOE2. Combining this evolutionary analysis and published research, the results suggest that typical AP2 group genes may first appear in gymnosperms and diverged in angiosperms, following expansion of group members and functional differentiation. In angiosperms, AP2 genes (AP2 clade inherited key functions from ancestors and other genes of AP2 group lost most function but just remained flowering time controlling in gene formation. In this study, the phylogenies of AP2 group genes in spermatophytes was analyzed, which supported the evidence for the research of gene functional evolution of AP2 group.

  17. Case studies in conservation science

    Science.gov (United States)

    Bisulca, Christina

    The research presented in this dissertation covers three separate topics of conservation as defined by the National Science Foundation: 1) Materials Stabilization, Strengthening, Monitoring, and Repair; 2. Understanding Material Degradation and Aging; and 3) Materials and Structural Characterization of Cultural Heritage Objects (the 'technical study'). The first topic is addressed through a study to assess the consolidant tetraethoxysilane for the stabilization of alum treated wood. Falling under materials degradation studies is a study published in American Museum Novitates to understand how environmental conditions affect the aging of fossil resins from five different deposits. Two separate studies are included in technical study of cultural heritage objects which comprises the third research area of materials characterization. The first is a survey of red dyes used in Chinese paintings from the Ming Dynasty to the Early Republic (1364-1911). The second is a study of the pigments, dyes and binders used in Hawaiian barkcloth (kapa) from the 19th century.

  18. AP Geography, Environmental Science Thrive

    Science.gov (United States)

    Robelen, Erik W.

    2012-01-01

    Geography may not be particularly known as a hot topic among today's students--even some advocates suggest it suffers from an image problem--but by at least one measure, the subject is starting to come into its own. Across more than 30 topics covered in the Advanced Placement (AP) program, participation in geography is rising faster than any…

  19. Case Studies in L2 Teacher Education.

    Science.gov (United States)

    Reichelt, Melinda

    2000-01-01

    Reports on the use of student-generated case studies in an English-as-a-Second-Language teacher education course, including the context, participants classroom procedures and case studies written, as well as students' responses to their use. (Author/VWL)

  20. A Case Study of "Empathetic Teaching Artistry"

    Science.gov (United States)

    Risner, Doug

    2014-01-01

    This case study is one of twenty cases derived from Anderson and Risner's international study of teaching artists in dance, and theatre, which investigated participants' (n=172) artistic and academic preparation in dance, and theatre, initial entry into the teaching artist field, rewards, challenges, and obstacles in participants' work, artists'…

  1. The Danish National Case Study Report

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    Three case studies from Danish science shops within the environmental field are analysed with respect to societal background, interaction between the involved actors and the societal impact of the co-operation. The report is one of the seven national case study reports from the EU...

  2. Case Studies in Middle Management Supervision

    Science.gov (United States)

    White, Lori S.

    2011-01-01

    This chapter presents a series of supervision-related case studies of situations that midlevel managers might face. Individuals enrolled in a midlevel management professional development course recommended the topics selected for this chapter. Drawing upon her experience teaching the course, the author selected four case studies that individuals…

  3. Five Misunderstandings About Case-Study Research

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2006-01-01

    useful for generating hypotheses, whereas other methods are more suitable for hypotheses testing and theory building; (d) the case study contains a bias toward verification; and (e) it is often difficult to summarize specific case studies. This article explains and corrects these misunderstandings one...

  4. Case studies--ergonomics in projects.

    Science.gov (United States)

    Pikaar, Ruud N

    2012-01-01

    The aim of a series of sessions on Company Case Studies, is to learn from practical experiences, to give feed back to researchers on applicability of theories, methods and techniques, and last but not least, to market ergonomics. In order to learn from case material, reports need to be easy accessible and well structured. System ergonomics provides such a structure. Usually a project is not done twice, i.e. with and without ergonomics. Therefore, it is not possible to make comparisons and determine the impact of ergonomics directly. A different approach is needed. It has been suggested at the IEA2006 World Congress, to compile a database of published case studies, each case to be reported in a fixed report format and critically reviewed to enable generalizing the outcomes. This paper proposes such a format. At the IEA2012 World Congress 40 case studies have been accepted, representing applied ergonomics cases in manufacturing, process industries, aviation and logistic systems.

  5. Leishmaniasis in dogs: Case study

    Directory of Open Access Journals (Sweden)

    Aleksić Jelena

    2009-01-01

    Full Text Available The paper presents a case of leishmaniasis in a 2.5-month-old dog imported from France. The clinical examination established a generally poor state of health, expressed cachexia, atrophy of the temporal musculature, weakness of movement, as well as abnormally long and brittle nails. There was also hyperkeratosis of the nose tip and paws. A histological examination of biopsy sections of the altered skin parts showed inflammatory changes in the area of the dermis, together with infiltration of macrophages and a smaller number of lymphocytes, plasmocytes and neutrophil granulocytes in the area around the sebaceous glands and hair follicles. The determined changes correspond to superficial dermatitis. Edema followed by partial degeneration of connective-tissue fibers is observed in connective tissue. A smaller number of intracellular parasitic forms was established in mononuclear cells. A smaller number of oval amastigotes with round dark red nucleis were observed in sections stained using the Gimza method in the cytoplasm of macrophages located in the dermis, but also extracellularly. It was concluded that the dog was diseased with leishmaniasis on the grounds of the clinical picture and the microscopic findings.

  6. Regional case studies--Africa.

    Science.gov (United States)

    Prentice, Andrew M

    2009-01-01

    Africa is the final continent to be affected by the nutrition transition and, as elsewhere, is characterized by the paradoxical coexistence of malnutrition and obesity. Several features of the obesity epidemic in Africa mirror those in other emerging nations: it penetrates the richer nations and urban areas first with a strong urban- rural gradient; initially it affects the wealthy, but later there is a demographic switch as obesity becomes a condition more associated with poverty, and it shares many of the same drivers related to the increasing affordability of highly refined oils and carbohydrates, and a move away from subsistence farm work and towards sedentary lifestyles. Africa also has some characteristics of the obesity epidemic that stand out from other regions such as: (1) excepting some areas of the Pacific, Africa is probably the only region in which obesity (especially among women) is viewed culturally as a positive and desirable trait, leading to major gender differences in obesity rates in many countries; (2) most of Africa has very low rates of obesity in children, and to date African obesity is mostly an adult syndrome; (3) Africans seem genetically prone to higher rates of diabetes and hypertension in association with obesity than Caucasians, but seem to be relatively protected from dislipidemias; (4) the case-specific deaths and disabilities from diabetes and hypertension in Africa are very high due to the paucity of health services and the strain that the 'double burden' of disease places on health systems.

  7. From single-case studies to practice-based knowledge: aggregating and synthesizing case studies.

    Science.gov (United States)

    Iwakabe, Shigeru; Gazzola, Nicola

    2009-07-01

    Recent developments in case study methodology reflect a rising interest that clinicians and researchers share in building a clinically useful and empirically sound knowledge base from single-case studies. The present article describes three types of single-case studies (clinical, experimental, systematic) and examines their potential contributions to psychotherapy research. It then lays out three ways in which single-case studies can be aggregated and synthesized to enhance clinical understanding: (a) a case database that allows clinicians to efficiently search for relevant cases, (b) a metasynthesis of single-case studies that integrates common themes across similar cases, and (c) an individual case comparison method in which closely matched cases are compared to identify both therapeutic and hindering processes.

  8. AP stars with resolved Zeeman split lines

    Science.gov (United States)

    Mathys, G.

    1990-06-01

    High-resolution, high SNR observations of a sample of sharp-lined A stars and of Ap stars showing resolved Zeeman split lines are presented. The Fe II lines 6147.7 A and 6149.2 A unexpectedly appear to be asymmetric in all stars where they are resolved. The blue component of the 6149.2 line, which is a Zeeman doublet, is deeper and narrower than its red component. For line 6147.7, whose Zeeman pattern does not differ much from a quadruplet, the red components are deeper than the blue ones. It is shown that a partial Paschen-Back effect can account for these properties. The potential implications of this finding for studies of magnetic Ap stars are discussed.

  9. Summary of case studies for cooperation mechanisms

    DEFF Research Database (Denmark)

    Longa, Francesco Dalla; Klinge Jacobsen, Henrik; Hansen, Lise-Lotte Pade;

    2012-01-01

    This document is a summary report highlighting the main aspect analyzed in the RES4LESS case studies. The document starts with an introductory chapter where the background that led to the selection of the case studies is outlined. In the following three chapters the case studies are presented......, highlighting the most relevant results. A brief chapter concludes the document, giving an outlook on the follow-up activities of the RES4LESS project. This summary is intended not only as an introduction to the RES4LESS cases studies, but also as a guideline to read and interpret the in-depth analysis carried...... out in the final documents that describe the case studies in detail. These documents will be published in September 2012 on the RES4LESS website, www.res4less.eu....

  10. Five case studies of multifamily weatherization programs

    Energy Technology Data Exchange (ETDEWEB)

    Kinney, L; Wilson, T.; Lewis, G. [Synertech Systems Corp. (United States); MacDonald, M. [Oak Ridge National Lab., TN (United States)

    1997-12-31

    The multifamily case studies that are the subject of this report were conducted to provide a better understanding of the approach taken by program operators in weatherizing large buildings. Because of significant variations in building construction and energy systems across the country, five states were selected based on their high level of multifamily weatherization. This report summarizes findings from case studies conducted by multifamily weatherization operations in five cities. The case studies were conducted between January and November 1994. Each of the case studies involved extensive interviews with the staff of weatherization subgrantees conducting multifamily weatherization, the inspection of 4 to 12 buildings weatherized between 1991 and 1993, and the analysis of savings and costs. The case studies focused on innovative techniques which appear to work well.

  11. Making a case for case studies in psychotherapy training

    DEFF Research Database (Denmark)

    Mackrill, Thomas Edward; Iwakabe, Shigeru

    2013-01-01

    The evidence debate in psychotherapy pays little attention to developing an evidence base for training practices. Understanding effective training requires an examination of what makes training work. This article examines the role of case studies in psychotherapy training. This has not been...... articulated explicitly or researched systematically in spite of its cardinal importance. An analysis of the role of case studies in psychotherapy training is presented. Reading, watching, or hearing about cases can offer novice psychotherapists access to a closed world; access to psychological theory...... in action; access to whole courses of therapy; access to different approaches; access to significant moments; access to the therapeutic relationship; access to a wide range of client types; access to working in different contexts; and the opportunity of identifying with therapists and clients. Writing...

  12. Theoretical pluralism in psychoanalytic case studies.

    Science.gov (United States)

    Willemsen, Jochem; Cornelis, Shana; Geerardyn, Filip M; Desmet, Mattias; Meganck, Reitske; Inslegers, Ruth; Cauwe, Joachim M B D

    2015-01-01

    The aim of this study is to provide an overview of the scientific activity of different psychoanalytic schools of thought in terms of the content and production of case studies published on ISI Web of Knowledge. Between March 2013 and November 2013, we contacted all case study authors included in the online archive of psychoanalytic and psychodynamic case studies (www.singlecasearchive.com) to inquire about their psychoanalytic orientation during their work with the patient. The response rate for this study was 45%. It appears that the two oldest psychoanalytic schools, Object-relations psychoanalysis and Ego psychology or "Classical psychoanalysis" dominate the literature of published case studies. However, most authors stated that they feel attached to two or more psychoanalytic schools of thought. This confirms that the theoretical pluralism in psychoanalysis stretches to the field of single case studies. The single case studies of each psychoanalytic school are described separately in terms of methodology, patient, therapist, or treatment features. We conclude that published case studies features are fairly similar across different psychoanalytic schools. The results of this study are not representative of all psychoanalytic schools, as some do not publish their work in ISI ranked journals.

  13. [Ergotamine poisoning: a case study].

    Science.gov (United States)

    Zapalska-Pozarowska, Karolina; Szponar, Jarosław; Górska, Agnieszka; Niewiedzioł, Marek

    2012-01-01

    Ergotamine is a well known pharmacological remedy applied in neurology (treatment of vascular headache) and in obstetrics (abortive remedy, uterus atony). But today it is rarely used, because of new safer anti-migraine medicine (triptanes) which cause fewer side effects. According to obstetrical indications ergotamine is applied only in hospital treatment. For that reason, cases of intoxication by this class of drugs are rarely observed. Ergotamine causes constriction of the blood vessels through the blockade of alpha-receptors and stimulation of the serotonin-receptors on the walls of blood vessels both in the central nervous system and in peripheral circulation. Intoxication/overdose symptoms may appear on application of therapeutic dose by sensitive patients, mostly by patients with migraine headache using ergotamine preparation for relief of migraine attacks. In the Regional Centre of Clinical Toxicology, a 21-year-old patient was hospitalized. She took about 20 tablets of Cafergot (complex preparation containing 1mg ergotamine tartare and 100mg caffeine). During her stay on the ward, typical symptoms of severe poisoning were observed: nausea, severe vomiting, dizziness, decreased blood pressure without perceptible pulse, narrowing of the blood vessels in the extremities of the body (peripheral vasoconstriction) - paresthesia, digital cyanosis, refrigeration of legs, angina. Due to taking once of a great dose of the drug by the patient, violent process of intoxication, possibility of dangerous complication and also the unavailability of specific antidotes and lack of efficient methods of extracorporeal elimination of the drug, the patient was intensively controlled and symptomatic treatments according to the law of intensive therapy was applied.

  14. Parametric study of the ductile damage by the Gurson–Tvergaard–Needleman model of structures in carbon steel A48-AP

    Directory of Open Access Journals (Sweden)

    Abdelkader Slimane

    2015-04-01

    Full Text Available This part of study is devoted to the numerical simulation of axisymmetric notched specimens in order to study the phenomenon of nucleation by Gurson–Tvergaard–Needleman model (GTN. The numerical simulations were performed to describe the damage of the materials using GTN model, which involves the stress triaxiality. The specimens chosen are somewhat axisymmetric notched (AN: hence, this choice was motivated by the symmetry of these specimens, and also by the existence of notches that make them interesting in the case of fracture mechanics.

  15. Outage management: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Haber, S.B.; Barriere, M.T. (Brookhaven National Lab., Upton, NY (United States)); Roberts, K.H. (California Univ., Berkeley, CA (United States). Walter A. Haas School of Business)

    1992-01-01

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission's (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study.

  16. Outage management: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Haber, S.B.; Barriere, M.T. [Brookhaven National Lab., Upton, NY (United States); Roberts, K.H. [California Univ., Berkeley, CA (United States). Walter A. Haas School of Business

    1992-09-01

    Outage management issues identified from a field study conducted at a two-unit commercial pressurized water reactor (PWR), when one unit was in a refueling outage and the other unit was at full power operation, are the focus of this paper. The study was conduced as part of the US Nuclear Regulatory Commission`s (NRC) organizational factors research program, and therefore the issues to be addressed are from an organizational perspective. Topics discussed refer to areas identified by the NRC as critical for safety during shutdown operations, including outage planning and control, personnel stress, and improvements in training and procedures. Specifically, issues in communication, management attention, involvement and oversight, administrative processes, organizational culture, and human resources relevant to each of the areas are highlighted by example from field data collection. Insights regarding future guidance in these areas are presented based upon additional data collection subsequent to the original study.

  17. Tratamento ortodôntico em pacientes com dentes reimplantados após avulsão traumática: relato de caso Orthodontic treatment in patients with reimplanted teeth after traumatic avulsion: a case report

    Directory of Open Access Journals (Sweden)

    Simone Requião Thá Rocha

    2010-08-01

    Full Text Available INTRODUÇÃO: a alta prevalência de indivíduos com traumatismo dentário prévio ao tratamento ortodôntico justifica os cuidados a serem observados antes e durante o tratamento, considerando todas as implicações do movimento ortodôntico sobre os dentes traumatizados. Entre as lesões traumáticas dentárias, a avulsão com posterior reimplantação do dente é a que apresenta maior risco de complicações - como necrose pulpar, reabsorção radicular e anquilose -, sendo também a que inspira maiores cuidados pelo ortodontista. OBJETIVO: este trabalho busca, através do relato de um caso clínico, analisar as implicações do reimplante dentário após avulsão traumática, em pacientes que requerem tratamento ortodôntico. CONCLUSÕES: a movimentação ortodôntica de um dente reimplantado, após sua avulsão traumática, é possível desde que não ocorra qualquer sinal de anormalidade. Porém, dentes que sofrem anquilose não são passíveis de movimentação ortodôntica, mas devem ser preservados como mantenedores de espaço, até a reabsorção total da raiz, desde que não apresentem infraposição severa. Ocorrendo infraposição severa do dente anquilosado, é indicada a amputação da coroa e o sepultamento da raiz, como meio de favorecer a manutenção do osso alveolar na região, pois ocorrerá reabsorção por substituição da raiz sepultada, como ocorreu no caso clínico apresentado.INTRODUCTION: The high prevalence of individuals with dental trauma prior to orthodontic treatment justifies the precautions that should be followed before and during treatment, considering all possible effects of orthodontic movement on traumatized teeth. Among the major traumatic dental injuries, avulsion with subsequent tooth reimplantation entails a higher than average risk of complications, such as pulp necrosis, root resorption and ankylosis. Therefore, it gives orthodontists several reasons for concern. OBJECTIVE: This case report sought

  18. Case Study Methodology and Homelessness Research

    Directory of Open Access Journals (Sweden)

    Jill Pable

    2013-10-01

    Full Text Available This paper describes the potential suitability of case study methodology for inquiry with the homeless population. It references a research study that uses case study research method to build theory. This study's topic is the lived experience of destitute individuals who reside in homeless shelters, and explores the homeless shelter built environment's potential influence on resident satisfaction and recovery. Case study methodology may be appropriate because it explores real-life contextual issues that characterize homelessness and can also accommodate the wide range of homeless person demographics that make this group difficult to study in a generalized fashion. Further, case study method accommodates the need within research in this area to understand individualized treatments as a potential solution for homelessness.

  19. Case Study on Quality Education

    Science.gov (United States)

    Habib, Zahida

    2011-01-01

    Quality of Education, especially at Primary level, is an important issue to be discussed at the International Forum. This study highlights the quality of primary education through a comparison of the quality of Community Model Schools and Govt. Girls Primary Schools in Pakistan. Community Model Schools were established under Girls Primary…

  20. Alterações cutâneas no Kwashiorkor: relato de caso de um homem adulto após cirurgia abdominal Cutaneous manifestations of kwashiorkor: a case report of an adult man after abdominal surgery

    Directory of Open Access Journals (Sweden)

    Danielle Mann

    2011-12-01

    Full Text Available Kwashiorkor é um tipo de desnutrição proteico-energética em que há deficiência dietética de proteína, embora a ingestão de calorias se mantenha adequada. As manifestações cutâneas incluem pele xerótica, com aspecto de esmalte descascado, típica coloração avermelhada a branco-acinzentada dos cabelos, o sinal da bandeira e edema mais evidente, nos membros inferiores e na face, dando aspecto de lua cheia. O presente artigo relata o caso de um paciente adulto, do sexo masculino, previamente submetido à duodenopancreatectomia para tratamento de pancreatite crônica associada ao pseudotumor em cabeça de pâncreas que evoluiu com alterações cutâneas de kwashiorkor após tuberculose pulmonar.Kwashiorkor is a type of protein-energy malnutrition where diet protein deficit is found, in spite of appropriate caloric intake. Cutaneous manifestations include xerosis, with abnormally dry skin that has a flaking enamel paint aspect, a typical red to gray-white hair color, the "flag sign" and more evident edema in lower limbs and face, giving it a full moon appearance. This article reports a case of a male adult patient who had undergone Whipple surgery for treatment of chronic pancreatitis associated with pseudotumor of the pancreatic head that progressed to cutaneous manifestations of kwashiorkor after pulmonary tuberculosis.

  1. Associative Visual Agnosia: A Case Study

    Directory of Open Access Journals (Sweden)

    A. Charnallet

    2008-01-01

    Full Text Available We report a case of massive associative visual agnosia. In the light of current theories of identification and semantic knowledge organization, a deficit involving both levels of structural description system and visual semantics must be assumed to explain the case. We suggest, in line with a previous case study [1], an alternative account in the framework of (non abstractive episodic models of memory [4].

  2. Arctic bioremediation -- A case study

    Energy Technology Data Exchange (ETDEWEB)

    Smallbeck, D.R.; Ramert, P.C. (Harding Lawson Associates, Novato, CA (United States)); Liddell, B.V.

    1994-05-01

    This paper discusses the use of bioremediation as an effective method to clean up diesel-range hydrocarbon spills in northern latitudes. The results of a laboratory study of microbial degradation of hydrocarbons under simulated arctic conditions showed that bioremediation can be effective in cold climates and led to the implementation of a large-scale field program. The results of 3 years of field testing have led to a significant reduction in diesel-range hydrocarbon concentrations in the contaminated area.

  3. Case Study: A Strategic Research Methodology

    Directory of Open Access Journals (Sweden)

    Khairul B.M. Noor

    2008-01-01

    Full Text Available This research reviews the literature on case study as a strategic qualitative research methodology. Although case studies have been criticised by some authors as lacking scientific rigour and do not address generalizability, this research, however, reiterated its appropriateness when dealing with a process or a complex real-life activities in great-depth. Case study has been commonly used in social science fields like sociology, industrial relations and anthropology eventhough generally was considered an underutilized strategy. Hence, this research explained the general concept of a case study, strengths and weaknesses of using this method knowing that theoretically case is exciting and data rich. Based on a study of four organizations and the researcher’s own experience, this article described matters on how case study was undertaken, gaining excess to those organizations and the systematic process of data collection and triangulation (multiple techniques. It was noted that combining multiple techniques for elicitng data in case study research actually strengthens and confirmed results.

  4. Clinical Study on Acute Pancreatitis in Pregnancy in 26 Cases

    Directory of Open Access Journals (Sweden)

    Cheng Qihui

    2012-01-01

    Full Text Available Aim. This paper investigated the pathogenesis and treatment strategies of acute pancreatitis (AP in pregnancy. Methods. We analyzed retrospectively the characteristics, auxiliary diagnosis, treatment strategies, and clinical outcomes of 26 cases of patients with AP in pregnancy. Results. All patients were cured finally. (1 Nine cases of 22 mild acute pancreatitis (MAP patients selected automatic termination of pregnancy because of the unsatisfied therapeutic efficacy or those patients’ requirements. (2 Four cases of all patients were complicated with severe acute pancreatitis (SAP; 2 cases underwent uterine incision delivery while one of them also received cholecystectomy, debridement and drainage of pancreatic necrosis, and percutaneous jejunostomy. One case had a fetal death when complicated with SAP; she had to receive extraction of bile duct stones and drainage of abdominal cavity after induced abortion. The other one case with hyperlipidemic pancreatitis was given induced abortion and hemofiltration. Conclusions. The first choice of MAP in pregnancy is the conventional therapy. Apart from the conventional therapy, we need to terminate pregnancy as early as possible for patients with SAP. Removing biliary calculi and drainage is supposed to be considered for acute biliary pancreatitis. Lowering blood lipids treatment should be applied to hyperlipidemic pancreatitis or given to hemofiltration when necessary.

  5. Case study on printed matter

    DEFF Research Database (Denmark)

    Introduction Existing product Life Cycle Assessments (LCA’s) on offset printed matter all point at paper as the overall dominating contributor to the impacts from the life-cycle of this category of products. This dominating role of paper is primarily founded in the energy-related impact categories...... include these chemical-related impact categories by making use of some of the newest knowledge about emissions from the production at the printing industry combined with knowledge about the composition of the printing materials used during the production of offset printed matter. This paper is based...... on the dissertation “Assessment of chemical emissions in life cycle impact assessment” (Larsen 2004) and the paper “Life-cycle assessment of offset printed matter with EDIP97 – how important are emissions of chemicals? “ (Larsen et al. 2009). Goal and scope The goal of the study is to identify the distribution...

  6. Case Study of above Average Elementary School

    Science.gov (United States)

    Mendez-Morse, Sylvia; Klinker, JoAnn Franklin

    2005-01-01

    This case study explores the duty of midmanagement administrators to enforce district policies with which they do not necessarily agree. The case addresses the issues of moral leadership, distribution of power, emotional responses that impact decision making, class differences, and equity. It also examines the role conflict that many married…

  7. Abbreviated Case Studies in Organizational Communication

    Science.gov (United States)

    Wanguri, Deloris McGee

    2005-01-01

    The cases contained within organizational communication texts are generally two to three pages, often followed by questions. These case studies are certainly useful. They generally describe events in the present, provide some type of organizational context, include first-hand data, include a record of what people say and think, develop a…

  8. Case Study Report about Gender Impact Assessment

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann; Agustin, Lise Rolandsen

    2013-01-01

    The aim of this national case study report is to take a closer look at the use of Gender Impact Assessments in Denmark in order to describe the Danish implementation of this specific Gender Mainstreaming method. By way of analyzing two selected cases (two law proposals put forward by The Danish...

  9. Music in context : Four case studies

    NARCIS (Netherlands)

    Randwijck, R.J.C. van

    2008-01-01

    In his thesis entitled “Music in Context. Four Case Studies”, R.J.C. van Randwijck investigates the context in which music has been created. It is a search in Four Case Studies, approaching four pieces of music from the context in which they were written in order to understand their meaning. The inv

  10. Case studies of steel structure failures

    Directory of Open Access Journals (Sweden)

    P. Bernasovský

    2010-01-01

    Full Text Available The contribution deals with some case studies of steel structure failures, which happened in Slovakia a few years ago. Features of cracking are illustrated on real cases of breakdowns in the transmission gas pipelines, at the cement works and in the petrochemical indus-try. All failures were caused by an incorrect technical approach. Possible remedial measures are proposed.

  11. Implementing Product Platforms: A Case Study

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil; Mortensen, Niels Henrik

    2006-01-01

    The paper describes a case study dealing with the process of creating and implementing a product platform. The paper espessially deals with the fact that to obtain the benefits of platforms a permanent change in behaviour in product development must be ensured. This change in behaviour requires...... acceptance and approval from the organisation in general and the commitment from management to enforce agreed-upon decisions. The case study itself was performed in the Danish company LEGO Group. The case study had two objectives: To create a technical architecture and align this architecture...

  12. Case study in professionally-oriented training

    Directory of Open Access Journals (Sweden)

    Valitov Shamil M.

    2016-01-01

    Full Text Available Modern educational technologies are based on competence approach and focus on the future professional activity. Case study is one of the most significant technologies in modern higher education. The basic concepts used in the case study method are a “situation” and an “analysis”, as well as their derivative - “analysis of the situation”. The case study method of is one of the best tools for gaining experience, as it investigates practical situations that occur in managerial job. It combines theoretical knowledge with the analysis of the actual practical experience in accordance with a major. Doing case studies students read the description of the situation and offer divergent projects of managerial decisions that could be used by real managers dealing with the problem posed by the case study author. Answers to the questions posed in the case description are not given, as a rule, since the main purpose in the case analysis is to organize a discussion in the classroom or provoke speculations of those who do the self-study.

  13. Antiphospholipid syndrome: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Davies, T. [Royal Adelaide Hospital, Adelaide, SA (Australia). Department of Nuclear Medicine

    1998-03-01

    Full text: A forty-two-year-old male presented to the Royal Adelaide Hospital with symptoms of increasing shortness of breath, swelling in both ankles, petechial rash and blood in his sputum. Initial investigations showed cardiomegaly, right ventricular hypertrophy, patchy lung infiltrates, a platelet count of 1500 and a clotting time of 60 seconds. A V/Q scan indicated a high probability of pulmonary embolism. Further investigations showed that the patient was positive for lupus anticoagulant and cardiolipin antibodies. A diagnosis of primary antiphospholipid syndrome was made. The patient``s high risk of strokes and hemorrhaging prompted investigation by a {sup 99}mTc-HMPAO brain scan. Further V/Q scans were performed to follow up the initial finding of multiple pulmonary embolism and a R-L shunt study was performed to investigate a left subclavian murmur. The patient was admitted for four weeks and began treatment which included cyclaphosphamide, corticosteroids and plasmaphoresis and was discharged when stable. Over the next six months he was re admitted three times for relapse of antiphospholipid syndrome. On his fourth admission he collapsed and died five hours after admission. Cause of death was due to cardiac arrhythmia secondary to severe right ventricular hypertrophy and dilation. The effects of antiphospholipid syndrome was believed to be responsible for this outcome.

  14. Energy Audit: A Case Study

    Directory of Open Access Journals (Sweden)

    Sanjay Kumar

    2013-06-01

    Full Text Available This India is the Fifth largest producer of Electricalenergy in the world. Despite such achievements the gapbetween demand and supply of electrical energy is increasingevery year and power sector is highly capital – intensive. Thusthe deficit in installed capacity was nearly 10000MWper year.So the gap between demand and supply is continuouslyincreasing day by day. An energy audit is a study of a plant orfacility to determine how and where energy is used and toidentify methods for energy savings. The opportunities lie inthe use of existing renewable energy technologies, greaterefforts at energy efficiency and the dissemination of thesetechnologies and options. This thesis provides an overview of ageneral energy conservation measures (ECMs that can becommonly recommended for NIT Hamirpur. It should be notedthat the Energy auidut presented in this paper does not pretendto be exhaustive nor comprehensive. It provides merely toindicate some of the options that energy auditor can considerwhen performing an analysis of this institute. Energyconservation and exploration of new energy avenues are thewell accepted solution to fulfil the demand in future. The totalcost of energy plays a vital role in determining the product costof a commodity. Therefore the identification of potential energysavings and implementation for a given institutional facility isunimportant to ensure its competitive advantage over otherinstitute. This paper work presents such energy saving methodsin a methodological approach, experienced during a detailedenergy audit of NIT Hamirpur.

  15. Trichomonas vaginalis: the adhesins AP51 and AP65 bind heme and hemoglobin.

    Science.gov (United States)

    Ardalan, Shahed; Lee, B Craig; Garber, Gary E

    2009-04-01

    Trichomonas vaginalis is the cause of human trichomoniasis, the most common non-viral sexually transmitted disease worldwide. Although acquisition of iron by binding to host hemoglobin through distinct receptor(s) has been described, no specific heme- or hemoglobin-binding site has been reported in this parasite. To determine the presence of hemoglobin-binding protein(s), membrane proteins were subjected to hemoglobin-affinity chromatography. Eluted proteins were analysed by SDS-PAGE. Two protein bands of 48 and 63 kDa were detected. Competition assay with an excess amount of hemoglobin or hemin in hemoglobin-affinity chromatography could block the 63- and 48-kDa bands, respectively. Further analysis by mass spectrometry indicated that the 48- and 63-kDa proteins had identity with two T. vaginalis adhesins: AP51 and AP65, respectively. This study confirms the existence of multifunctional proteins in T. vaginalis, and suggested that AP51 and AP65, besides serving as adhesion molecules, could also act as heme- and hemoglobin-binding proteins.

  16. Plexopatia lombar após histerectomia abdominal: relato de caso Plexopatía lumbar después de la histerectomía abdominal: relato de caso Lumbar plexopathy after abdominal hysterectomy: case report

    Directory of Open Access Journals (Sweden)

    Elizabeth Vaz da Silva

    2006-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As lesões neurológicas diagnosticadas no período pós-operatório muitas vezes são atribuídas ao ato anestésico, embora possam também decorrer do ato cirúrgico. O objetivo deste relato foi apresentar o caso de uma paciente submetida à intervenção cirúrgica pélvica que evoluiu com quadro de plexopatia lombar e discutir as possíveis causas. RELATO DO CASO: Paciente do sexo feminino, 38 anos, 58 kg, 1,63 m de altura, estado físico ASA I, internada para tratamento de leiomiomatose uterina, com indicação de histerectomia total abdominal. A monitorização inicial incluiu oxímetro de pulso, pressão arterial não-invasiva, eletrocardioscópio e diurese. Após punção venosa no membro superior esquerdo com cateter 18G, foram administrados, por via venosa, cefazolina (2 g, dipirona (2 g, dexametasona (10 mg e metoclopramida (10 mg. A anestesia peridural foi realizada com agulha Tuohy 16G, no espaço L3-L4, na linha mediana com a paciente em decúbito lateral esquerdo. Foram administrados 15 mL de ropivacaína a 0,75% e 2 mg de morfina, a seguir posicionado cateter para analgesia pós-operatória. A intervenção cirúrgica não teve intercorrência, mantendo-se a paciente estável sob o ponto de vista cardiovascular. Na visita pós-anestésica, oito horas após o procedimento, a paciente não deambulava e apresentava monoparesia no membro inferior esquerdo. Após investigações clínicas e radiológicas foi descartada a hipótese diagnóstica de síndrome radicular. Como não houve regressão do quadro, 30 dias após foi realizada eletroneuromiografia que foi compatível com plexopatia lombar de possível origem traumática. CONCLUSÕES: O anestesiologista deve estar atento às complicações neurológicas que podem surgir no pós-operatório, participando da elucidação das causas, do tratamento e da sua evolução.JUSTIFICATIVA Y OBJETIVOS: Las lesiones neurológicas diagnosticadas en el per

  17. Tratamento da recidiva da leucemia mielóide crônica após transplante de medula óssea alogênico utilizando mesilato de imatinibe: relato de três casos Treatment of chronic myelogenous leukemia relapse after allogeneic bone marrow transplantation with imatinib mesylate: report of three cases

    Directory of Open Access Journals (Sweden)

    Ronald Pallotta

    2006-06-01

    Full Text Available O mesilato de imatinibe (MI, inibidor seletivo da tirosinoquinase envolvido na patogênese da leucemia mielóide crônica (LMC, tem se constituído como terapia farmacológica de primeira linha para o tratamento desta doença. A infusão de linfócitos do doador (DLI tem sido considerada como tratamento padrão para recidiva da LMC após transplante de medula óssea (TMO alogênico, apesar de estar freqüentemente associado à ocorrência de doença do enxerto contra hospedeiro e mielossupressão. Por apresentar resultados satisfatórios e boa tolerabilidade no tratamento da LMC, os autores empregaram o mesilato de imatinib como terapêutica alternativa à DLI em pacientes que sofreram recidiva após o TMO. Obtiveram sucesso em dois casos, sendo que em um houve retorno comprovado do quimerismo do doador. No terceiro caso houve progressão da doença e o paciente foi encaminhado para segundo TMO. Desta forma, devido ao caráter recente do tema, este estudo descritivo sugere que esta opção terapêutica possa ser estudada como alternativa na recaída pós-TMO.Imatinib mesylate (MI, a selective tyrosine kinase inhibitor involved in the pathogenesis of chronic myelogenous leukemia (CML, has become the first-line treatment for this disease. Donor lymphocyte infusion (DLI has been considered as the standard treatment for relapse after allogeneic bone marrow transplantation (BMT, even though it is frequently associated with graft versus host disease and myelosuppression. Because of the satisfactory results and tolerance of the treatment of CML, the authors used MI as an alternative therapy for DLI in patients that relapsed after BMT. They obtained cytogenetic remission in two cases, with, in one case, proven conversion to the donor chimera. The third case evolved with progression of the disease and a second BMT was required. Since this is a new alternative, this descriptive study suggests it should be considered as an alternative therapy for relapse

  18. Case Study Orientation for New Teachers.

    Science.gov (United States)

    Richardson, James M.

    1979-01-01

    This article describes Oldfields School's systematic orientation program for beginning teachers. They meet as a group and discuss case studies, which give substance to the regulations and policies listed in the school handbooks. (SJL)

  19. Towards More Case Study Research in Entrepreneurship

    Directory of Open Access Journals (Sweden)

    Tom Duxbury

    2012-03-01

    Full Text Available Entrepreneurship as an emerging discipline has made good strides, but according to some, has fallen short of bringing its theory and literature up to the standards of others in the management sciences. Rich with the descriptive detail needed for insightful theory building in entrepreneurship, scholars have called for more case study research, particularly those incorporating non-retrospective and longitudinal observations. At the same time however, it has become rare to find such research published in A-level journals dedicated to entrepreneurship. A survey presented here of major entrepreneurship journals over the past six years revealed a publication rate of only 3% using the case study method. This presents a major impediment for developing fresh research in this field based upon the study of real cases. The author explores how the case study method has been applied to entrepreneurship research and provides recommendations for improved publication rates.

  20. Analysis of an accident type sbloca in reactor contention AP1000 with 8.0 Gothic code; Analisis de un accidente tipo Sbloca en la contencion del reactor AP1000 con el codigo Gothic 8.0

    Energy Technology Data Exchange (ETDEWEB)

    Goni, Z.; Jimenez Varas, G.; Fernandez, K.; Queral, C.; Montero, J.

    2016-08-01

    The analysis is based on the simulation of a Small Break Loss-of-Coolant-Accident in the AP1000 nuclear reactor using a Gothic 8.0 tri dimensional model created in the Science and Technology Group of Nuclear Fision Advanced Systems of the UPM. The SBLOCA has been simulated with TRACE 5.0 code. The main purpose of this work is the study of the thermo-hydraulic behaviour of the AP1000 containment during a SBLOCA. The transients simulated reveal close results to the realistic behaviour in case of an accident with similar characteristics. The pressure and temperature evolution enables the identification of the accident phases from the RCS point of view. Compared to the licensing calculations included in the AP1000 Safety Analysis, it has been proved that the average pressure and temperature evolution is similar, yet lower than the licensing calculations. However, the temperature and inventory distribution are significantly heterogeneous. (Author)

  1. Anencephaly: A pathological study of 41 cases

    Directory of Open Access Journals (Sweden)

    C Panduranga

    2012-01-01

    Full Text Available Background : Anencephaly is a lethal neural tube defect which is due to the defective closure of rostral pore of neural tube. In more than 50% of cases it is associated with other systemic anomalies. Hence this study was undertaken to assess pathological parameters associated with anencephaly in particular attention to associated systemic anomalies. Materials and Methods: It is a study on 41 anencephaly fetuses conducted in the Department of Pathology. The period of study is from January 2001 to December 2011. Results: Out of 41 cases, 30 (73% cases showed presence of systemic anomalies, 48.5% of the cases were observed in primigravida. Most common associated anomaly was spina bifida followed by gastrointestinal anomalies. Conclusion: Pathological examination of the abortus is essential to document the associated anomalies.

  2. Effect of multifunctional protein YB-1 on the AP site cleavage by AP endonuclease 1 and tyrosyl phosphodiesterase 1

    Directory of Open Access Journals (Sweden)

    Ovchinnikov L. P.

    2012-07-01

    Full Text Available Apurinic/apyrimidinic sites (AP sites which represent one of the most abundantly generated DNA lesions in the cell are generally repaired by base excision repair (BER pathway. Multifunctional protein YB-1 is known to participate in cellular response to genotoxic stress and was shown to interact with several components of BER – DNA glycosylases NTH1, NEIL2, DNA polymerase and DNA ligase III. Therefore, it is of great interest to investigate the influence of YB-1 on one of the major BER enzymes, responsible for AP site cleavage, AP endonuclease APE1, and on tyrosyl phosphodiesterase Tdp1, participating in APE1 independent pathway of AP site repair. Aim. Effect of multifunctional protein YB-1 on the AP site cleavage by the activities of APE1 and Tdp1 was studied. Methods. Gel-mobility shift assays and enzyme activity tests. Results. YB-1 was shown to inhibit the cleavage of AP site located in single-stranded DNA by both APE1 and Tdp1. Stimulation of APE1 activity on protruding double-stranded DNA in the presence of YB-1 was observed, whereas no effect on Tdp1-mediated cleavage of AP site in double-stranded DNA was found. Conclusions. YB-1 can modulate the repair of AP sites in DNA by both positively stimulating APE1 during the classic BER of AP sites and avoiding a possible generation of doublestrand breaks, arising from the cleavage of single-stranded portion of DNA substrate already used by different DNA-processing pathway

  3. Case studies of nurseries in Malawi

    DEFF Research Database (Denmark)

    Namoto, M.; Likoswe, M.G.

    This study of 42 case studies of nurseries was made as part of a major sample survey of 360 nurseries in 6 districts in Malawi. The purpose of the study was to let the small nurseries in the country explain in their own words how they source seed, how and for whom they produce seedlings...

  4. Predicting Students Drop Out: A Case Study

    Science.gov (United States)

    Dekker, Gerben W.; Pechenizkiy, Mykola; Vleeshouwers, Jan M.

    2009-01-01

    The monitoring and support of university freshmen is considered very important at many educational institutions. In this paper we describe the results of the educational data mining case study aimed at predicting the Electrical Engineering (EE) students drop out after the first semester of their studies or even before they enter the study program…

  5. An AP Calculus Classroom Amusement Park

    Science.gov (United States)

    Ferguson, Sarah

    2016-01-01

    Throughout the school year, AP Calculus teachers strive to teach course content comprehensively and swiftly in an effort to finish all required material before the AP Calculus exam. As early May approaches and the AP Calculus test looms, students and teachers nervously complete lessons, assignments, and assessments to ensure student preparation.…

  6. Heterologous expression of ApGSMT2 and ApDMT2 genes from Aphanothece halophytica enhanced drought tolerance in transgenic tobacco.

    Science.gov (United States)

    He, Ying; He, Chunmei; Li, Lihua; Liu, Zhili; Yang, Aifang; Zhang, Juren

    2011-01-01

    The glycine-methylation biosynthetic pathway of glycinebetaine (GB) has been investigated, but only a few studies on GB accumulation in transgenic higher plants have utilized this pathway. In this study, two methyltransferase genes named ApGSMT2 and ApDMT2, encoding proteins catalyzing GB biosynthesis from glycine, were cloned from a relative strain of Aphanothece halophytica. The potential roles of ApGSMT2 and ApDMT2 in GB synthesis were first examined in transgenic Escherichia coli, which had increased levels of GB and improved salt tolerance. Then ApGSMT2 and ApDMT2 were transferred into tobacco. Compared with transgenic tobacco expressing betA, transgenic tobacco co-expressing ApGSMT2 and ApDMT2 accumulated more GB and exhibited enhanced drought resistance with better germination performance, higher relative water content, less cell membrane damage and better photosynthetic capacity under drought stress. We concluded that the ApGSMT2 and ApDMT2 genes cloned in this study will be very useful for engineering GB-accumulating transgenic plants with enhanced drought resistance.

  7. Opportunistic detection of atrial fibrillation in subjects aged 65 years or older in primare care: a randomised clinical trial of efficacy. DOFA-AP study protocol

    Directory of Open Access Journals (Sweden)

    Pérula-de-Torres LuisÁ

    2012-10-01

    Full Text Available Abstract Background Clinical Practice Guidelines recommend using peripheral blood pulse measuring as a screening test for Atrial Fibrillation. However, there is no adequate evidence supporting the efficacy of such procedure in primary care clinical practice. This paper describes a study protocol designed to verify whether early opportunistic screening for Atrial Fibrillation by measuring blood pulse is more effective than regular practice in subjects aged 65 years attending primary care centers. Methods/design An cluster-randomized controlled trial conducted in Primary Care Centers of the Spanish National Health Service. A total of 269 physicians and nurses will be allocated to one of the two arms of the trial by stratified randomization with a 3:2 ratio (three practitioners will be assigned to the Control Group for every two practitioners assigned to the Experimental Group. As many as 12 870 patients aged 65 years or older and meeting eligibility criteria will be recruited (8 580 will be allocated to the Experimental Group and 4 290 to the Control Group. Randomization and allocation to trial groups will be carried out by a central computer system. The Experimental Group practitioners will conduct an opportunistic case finding for patients with Atrial Fibrillation, while the Control Group practitioners will follow the regular guidelines. The first step will be finding new Atrial Fibrillation cases. A descriptive inferential analysis will be performed (bivariate and multivariate by multilevel logistic regression analysis. Discussion If our hypothesis is confirmed, we expect Primary Care professionals to take a more proactive approach and adopt a new protocol when a patient meeting the established screening criteria is identified. Finally, we expect this measure to be incorporated into Clinical Practice Guidelines. Trial registration The study is registered as NCT01291953 (ClinicalTrials.gob

  8. Case Study Research Methodology in Nursing Research.

    Science.gov (United States)

    Cope, Diane G

    2015-11-01

    Through data collection methods using a holistic approach that focuses on variables in a natural setting, qualitative research methods seek to understand participants' perceptions and interpretations. Common qualitative research methods include ethnography, phenomenology, grounded theory, and historic research. Another type of methodology that has a similar qualitative approach is case study research, which seeks to understand a phenomenon or case from multiple perspectives within a given real-world context.

  9. Gigantic Suprapubic Lymphedema: A Case Study

    Science.gov (United States)

    Tanhaeivash, Roozbeh; Franiel, Tobias; Grimm, Marc-Oliver

    2016-01-01

    We present the first case study of idiopathic gigantic suprapubic lymphedema and buried penis treated with puboscrotal reconstruction in a patient with initial extreme obesity after an extensive weight reduction (120 kg). Massive localized lymphedema of the suprapubic region should be differentiated from the scrotal type. Severe lymphedema could not resolve on its own and weight reduction does not seem to be helpful in such cases. PMID:27574599

  10. Fellow's Apéro

    CERN Multimedia

    Staff Association

    2017-01-01

    Let's get together, meet each other, exchange experiences and ideas, and share useful information on CERN and the Staff Association. Join us for Fellow's Apéro, organised by the Staff Association on Tuesday 21 February at 16.30 in Restaurant 1. There will be drinks and snacks for everybody! We look forward to seeing you there! Please confirm your participation on Doodle http://doodle.com/poll/skvm7ucm2z78i6bt or alternatively on Facebook https://www.facebook.com/events/1862757017340069/. Your delegates in the Staff Association, Barbora & Jiri

  11. Testing of Solar Heated Domestic Hot Water System for Solahart Scandinavia ApS

    DEFF Research Database (Denmark)

    Andersen, Elsa

    1997-01-01

    The solar heating system marketed by Solahart Scandinavia ApS was tested in the Institutes test facility for SDHWsystems. The test results are described in the report.......The solar heating system marketed by Solahart Scandinavia ApS was tested in the Institutes test facility for SDHWsystems. The test results are described in the report....

  12. [Asteroid hyalopathy. Ultrastructural study of 3 cases].

    Science.gov (United States)

    Adenis, J P; Leboutet, M J; Loubet, R

    1984-01-01

    The vitreous of three patients with asteroïd hyalosis (average age: 57 years) was obtained by a two-hand closed pars plana vitrectomy. Asteroïd hyalosis was associated with alcoholic neuropathy in the first case, long standing retinal detachment in the second case, and diabetes mellitus in the third case. The visual acuity before and after the surgical procedure improved from 1.2/6 to 6/6 in the first case, from light perception to 0.3/6 in the second case, from 0.6/6 to 4.8/6 in the third case. The vitreous was studied by different ultrastructural technics : transmission electron microscopy (T.E.M.) scanning electron microscopy (S.E.M.) and electron diffraction X ray analysis (E.D.A.X.). By S.E.M. the asteroïd bodies appeared as rounded structures with an irregular surface connected to each other by fibrous strands among sodium chloride crystals. No cellular remnants were observed. By T.E.M. the asteroïd bodies were composed of interwinned ribbons of multilaminar membranes with a periodicity (10 to 60 A) characteristic of complex lipids, especially phospholipids. At the edge of the ribbons there were dots and sometimes clumps of opaque material that tended to crack out of the specimen with the heat of the electron beam. T.E.M. study disclosed the irregular disposition of the calcific bodies. By E.D.A.X. the calcific composition of the rounded structures could be determined : calcium and phosphorus were the main elements detectable in asteroïd bodies of all sizes for all three patients. The average calcium counts for the three successive cases were : 18, 30, 43 and for phosphorus : 9, 14, 26. Potassium was found in the first case, and sulfur in the third case.(ABSTRACT TRUNCATED AT 250 WORDS)

  13. Ozone mitigation tests at the APS

    Energy Technology Data Exchange (ETDEWEB)

    Kuzay, T.M.; Collins, J.T.; Pisharody, M.; Job, P.K.; Wang Zhibi

    1996-09-01

    Ozone is generated in the APS experimental stations whenever the x-ray beam has a chance to interact with air. Ozone concentrations in an experimental station have to be below a certain defined limit (current OSHA regulations specify 0.08 ppm as the maximum limit) before an experimenter can reenter the hutch. This limit is said to be currently under study for a downward adjustment. One method of depleting the ozone generated in an experimental station is mitigation through either adsorption or direct destruction. In recent tests, both methods were tried using commercially available units. Test results and some analytical predictions are presented.

  14. Wiley AP english language and composition

    CERN Document Server

    Woods, Geraldine

    2013-01-01

    Two full-length practice tests to help you score your highest Review questions with complete answers and explanations for the most popular themes on the test Study strategies and expert test-taking tips to keep you calm and focused on test day Review key exam topics and themes to maximize your score Preparing for the AP English Language and Composition test? This test-prep guide helps you perfect the skills you need to achieve your best possible score. You'll find winning test-taking tips, multiple-choice strategies, and essay guidelines, as well as great advice on getting the

  15. Nanomaterial Case Study: A Comparison of Multiwalled ...

    Science.gov (United States)

    The draft document is intended to be used as part of a process to identify what is known and, more importantly, what is not yet known that could be of value in assessing the broad implications of specific nanomaterials. Like previous case studies (see History/ Chronology below), this draft case study on multiwalled carbon nanotubes (MWCNTs) is based on the comprehensive environmental assessment (CEA) approach, which consists of both a framework and a process. Unlike previous case studies this case study incorporates information about a traditional (i.e., “non-nano-enabled”) product, against which the MWCNT flame-retardant coating applied to upholstery textiles (i.e., the “nano-enabled” product) can be compared. The comparative element serves dual-purposes: 1) to provide a more robust database that facilitates identification of data gaps related to the nano-enabled product and 2) to provide a context for identifying key factors and data gaps for future efforts to evaluate risk-related trade-offs between a nano-enabled and non-nano-enabled product. This draft case study does not represent a completed or even a preliminary assessment of MWCNTs; rather, it uses the CEA framework to structure information from available literature and other resources (e.g., government reports) on the product life cycle, fate and transport processes in various environmental media, exposure-dose characterization, and impacts in human, ecological, and environmental receptors.

  16. The Glioma International Case-Control Study

    DEFF Research Database (Denmark)

    Amirian, E Susan; Armstrong, Georgina N; Zhou, Renke

    2016-01-01

    describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen...

  17. Connecting Reading and Writing: A Case Study

    Science.gov (United States)

    Li, Zhanfang

    2015-01-01

    Connecting reading and writing, proposed by many scholars, is realized in this case study. The 30 participants in this study are the English majors of the third year in one School of Foreign Languages in Beijing. They are encouraged to write journals every week, based on the source text materials in their Intensive Reading class, with the final…

  18. A Multiple Case Study of Innovation

    Science.gov (United States)

    Zheng, Wei; Khoury, Anne E.

    2008-01-01

    This study aims to explore how leadership and contextual factors influence innovation in R&D teams in national laboratories, using the approach of multiple case studies. This paper provides some preliminary findings from two highly innovative teams residing in two national laboratories in the US. The preliminary results suggested several common…

  19. Prader-Willi Disease: A Case Study.

    Science.gov (United States)

    Forbus, William R., III

    A case study focuses on the characteristics and physical management of a 15-year-old with Prader-Willi Syndrome, a birth defect associated with hypotonia, insatiable appetite, hypogonadism, central nervous system dysfunction, and abnormal growth and development . A literature review addresses studies dealing with behavior modification of obesity…

  20. Measuring marketing performance - A case study

    OpenAIRE

    Laakso, Vesa-Pekka

    2011-01-01

    PURPOSE OF THE STUDY The purpose of this study is to develop a marketing dashboard for a Finnish company that operates in the financial industry. The identification of suitable metrics for assessing marketing performance is considered central. This study proposes a new construct (a dashboard) that aims to providing management relevant information on marketing performance from decision-making perspective. METHODOLOGY AND DATA The methodology is a constructive case study. In the...

  1. AP600 containment purge radiological analysis

    Energy Technology Data Exchange (ETDEWEB)

    O`Connor, M.; Schulz, J.; Tan, C. [Bechtel Power Corporation (United States)] [and others

    1995-02-01

    The AP600 Project is a passive pressurized water reactor power plant which is part of the Design Certification and First-of-a-Kind Engineering effort under the Advanced Light Water Reactor program. Included in this process is the design of the containment air filtration system which will be the subject of this paper. We will compare the practice used by previous plants with the AP600 approach to meet the goals of industry standards in sizing the containment air filtration system. The radiological aspects of design are of primary significance and will be the focus of this paper. The AP600 Project optimized the design to combine the functions of the high volumetric flow rate, low volumetric flow rate, and containment cleanup and other filtration systems into one multi-functional system. This achieves a more simplified, standardized, and lower cost design. Studies were performed to determine the possible concentrations of radioactive material in the containment atmosphere and the effectiveness of the purge system to keep concentrations within 10CFR20 limits and within offsite dose objectives. The concentrations were determined for various reactor coolant system leakage rates and containment purge modes of operation. The resultant concentrations were used to determine the containment accessibility during various stages of normal plant operation including refueling. The results of the parametric studies indicate that a dual train purge system with a capacity of 4,000 cfm per train is more than adequate to control the airborne radioactivity levels inside containment during normal plant operation and refueling, and satisfies the goals of ANSI/ANS-56.6-1986 and limits the amount of radioactive material released to the environment per ANSI/ANS 59.2-1985 to provide a safe environment for plant personnel and offsite residents.

  2. Integrating Ethics into Case Study Assignments

    Directory of Open Access Journals (Sweden)

    Pamela A. Marshall

    2014-08-01

    Full Text Available I teach an upper-level writing course, Genes, Race, Gender, and Society, designed for Life Science majors, in which I utilize a case study to expose students to ethical ways of thinking.  Students first work through the topical case study and then are challenged to rethink their responses through the lenses of ethics, taking into account different ethical frameworks.  Students then develop their own case study, integrating ethical components.  I want to expose my students to this way of thinking because I see technology being driven by the Jurassic Park phenomenon, "Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should." and want future physicians grounded in a sense of how their actions relate to the greater good.

  3. Cryostat design case studies, principles and engineering

    CERN Document Server

    2016-01-01

    This book enables the reader to learn the fundamental and applied aspects of practical cryostat design by examining previous design choices and resulting cryostat performance. Through a series of extended case studies the book presents an overview of existing cryostat design covering a wide range of cryostat types and applications, including the magnet cryostats that comprise the majority of the Large Hadron Collider at CERN, space-borne cryostats containing sensors operating below 1 K, and large cryogenic liquid storage vessels. It starts with an introductory section on the principles of cryostat design including practical data and equations. This section is followed by a series of case studies on existing cryostats, describing the specific requirements of the cryostat, the challenges involved and the design choices made along with the resulting performance of the cryostat. The cryostat examples used in the studies are chosen to cover a broad range of cryostat applications and the authors of each case are ...

  4. Shuttle Case Study Collection Website Development

    Science.gov (United States)

    Ransom, Khadijah S.; Johnson, Grace K.

    2012-01-01

    As a continuation from summer 2012, the Shuttle Case Study Collection has been developed using lessons learned documented by NASA engineers, analysts, and contractors. Decades of information related to processing and launching the Space Shuttle is gathered into a single database to provide educators with an alternative means to teach real-world engineering processes. The goal is to provide additional engineering materials that enhance critical thinking, decision making, and problem solving skills. During this second phase of the project, the Shuttle Case Study Collection website was developed. Extensive HTML coding to link downloadable documents, videos, and images was required, as was training to learn NASA's Content Management System (CMS) for website design. As the final stage of the collection development, the website is designed to allow for distribution of information to the public as well as for case study report submissions from other educators online.

  5. Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models

    Science.gov (United States)

    Badavi, Francis F.; Walker, Steven A.; Santos Koos, Lindsey M.

    2015-04-01

    The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow

  6. Low Earth orbit assessment of proton anisotropy using AP8 and AP9 trapped proton models.

    Science.gov (United States)

    Badavi, Francis F; Walker, Steven A; Santos Koos, Lindsey M

    2015-04-01

    The completion of the International Space Station (ISS) in 2011 has provided the space research community with an ideal evaluation and testing facility for future long duration human activities in space. Ionized and secondary neutral particles radiation measurements inside ISS form the ideal tool for validation of radiation environmental models, nuclear reaction cross sections and transport codes. Studies using thermo-luminescent detectors (TLD), tissue equivalent proportional counter (TPEC), and computer aided design (CAD) models of early ISS configurations confirmed that, as input, computational dosimetry at low Earth orbit (LEO) requires an environmental model with directional (anisotropic) capability to properly describe the exposure of trapped protons within ISS. At LEO, ISS encounters exposure from trapped electrons, protons and geomagnetically attenuated galactic cosmic rays (GCR). For short duration studies at LEO, one can ignore trapped electrons and ever present GCR exposure contributions during quiet times. However, within the trapped proton field, a challenge arises from properly estimating the amount of proton exposure acquired. There exist a number of models to define the intensity of trapped particles. Among the established trapped models are the historic AE8/AP8, dating back to the 1980s and the recently released AE9/AP9/SPM. Since at LEO electrons have minimal exposure contribution to ISS, this work ignores the AE8 and AE9 components of the models and couples a measurement derived anisotropic trapped proton formalism to omnidirectional output from the AP8 and AP9 models, allowing the assessment of the differences between the two proton models. The assessment is done at a target point within the ISS-11A configuration (circa 2003) crew quarter (CQ) of Russian Zvezda service module (SM), during its ascending and descending nodes passes through the south Atlantic anomaly (SAA). The anisotropic formalism incorporates the contributions of proton narrow

  7. Roles of AP-2 in clathrin-mediated endocytosis.

    Directory of Open Access Journals (Sweden)

    Emmanuel Boucrot

    Full Text Available BACKGROUND: The notion that AP-2 clathrin adaptor is an essential component of an endocytic clathrin coat appears to conflict with recent observations that substantial AP-2 depletion, using RNA interference with synthesis of AP-2 subunits, fails to block uptake of certain ligands known to internalize through a clathrin-based pathway. METHODOLOGY/PRINCIPAL FINDINGS: We report here the use of in vivo imaging data obtained by spinning-disk confocal microscopy to study the formation of clathrin-coated structures at the plasma membranes of BSC1 and HeLa cells depleted by RNAi of the clathrin adaptor, AP-2. Very few clathrin coats continue to assemble after AP-2 knockdown. Moreover, there is a total absence of clathrin-containing structures completely lacking AP-2 while all the remaining coats still contain a small amount of AP-2. These observations suggest that AP-2 is essential for endocytic coated-pit and coated-vesicle formation. We also find that AP-2 knockdown strongly inhibits light-density lipoprotein (LDL receptor-mediated endocytosis, as long as cells are maintained in complete serum and at 37 degrees C. If cells are first incubated with LDL at 4 degrees C, followed by warming, there is little or no decrease in LDL uptake with respect to control cells. LDL uptake at 37 degrees C is also not affected in AP-2 depleted cells first deprived of LDL by incubation with either serum-starved or LDL-starved cells for 24 hr. The LDL-deprived cells display a significant increase in endocytic structures enriched on deeply invaginated tubes that contain LDL and we suggest that under this condition of stress, LDL might enter through this alternative pathway. CONCLUSIONS/SIGNIFICANCE: These results suggest that AP-2 is essential for endocytic clathrin coated-pit and coated-vesicle formation. They also indicate that under normal conditions, functional endocytic clathrin coated pits are required for LDL internalization. We also show that under certain

  8. 废磷酸三异戊酯有机溶剂的间接电化学氧化分解行为研究%Study on Mediated Electrochemical Oxidation for Destruction of Spent TiAP Solvent

    Institute of Scientific and Technical Information of China (English)

    李辉波; 袁洁琼; 苏哲; 朱桐宇; 苏明业

    2014-01-01

    A silver mediated electrochemical oxidation is a promising technique for the destruction of organic compounds .The destruction of spent organic solvent in nitric acid medium containing Ag + was studied by using a laboratory scale electrochemical oxidation cell and fresh 30% tri-isoamyl phosphate (TiAP) .The factors affecting the generation of Ag2 + and its capability to decompose TiAP were investigated , which include temperature , nitric acid concentration and current density . T he results show that the generation of Ag2+ increases with the concentrations of HNO3 and Ag+ and reduces with the increase of temperature .It is also found that the destruction rate of TiAP is 99.9% with a temperature of 40 ℃ ,a nitric acid concentration of 8 mol/L ,and a current density of 0.5 A/cm2 for 8 h .%银媒介间接电化学氧化(A g/M EO )技术是一种有机溶剂分解破坏的有效方法。本文采用小型氧化电解池和新鲜磷酸三异戊酯(TiAP)有机溶剂模拟研究了在含 Ag+的 HNO3溶液体系中氧化分解TiAP ,包括电解氧化过程中阳极室 HNO3浓度、操作温度等条件对Ag2+产生量的影响,以及影响Ag2+氧化分解TiAP有机溶剂的相关因素。研究结果表明,溶液中Ag+和HNO3浓度的提高有利于Ag2+的生成;操作温度的升高,不利于Ag2+的生成。最佳条件为:温度,40℃;HNO3浓度,8 mol/L;电流密度,0.5 A/cm2。在此条件下,8 h可将99.9%的T iA P氧化分解。

  9. Repurposing legacy data innovative case studies

    CERN Document Server

    Berman, Jules J

    2015-01-01

    Repurposing Legacy Data: Innovative Case Studies takes a look at how data scientists have re-purposed legacy data, whether their own, or legacy data that has been donated to the public domain. Most of the data stored worldwide is legacy data-data created some time in the past, for a particular purpose, and left in obsolete formats. As with keepsakes in an attic, we retain this information thinking it may have value in the future, though we have no current use for it. The case studies in this book, from such diverse fields as cosmology, quantum physics, high-energy physics, microbiology,

  10. Presenting Software Metrics Indicators- A Case Study

    DEFF Research Database (Denmark)

    Pantazos, Kostas; Shollo, Arisa; Staron, Miroslaw;

    2010-01-01

    decisions based on indicators. In essence, visualizing indicators and their dependencies can communicate the information to the stakeholders efficiently if done correctly, or mislead them if not done properly. In this paper we present results of a case study conducted in a unit of Ericsson. During the case...... study we identified the main requirements for methods for visualizing the indicators, developed these visualizations and conducted a series of interviews evaluating them. The results show that the dashboard presentation is the best solution, but that the simple, tabular visualizations are next best...

  11. SYNONYMS IN ACTION: A CASE STUDY

    Directory of Open Access Journals (Sweden)

    Rebecca Clift

    2003-05-01

    Full Text Available This paper discusses what the methods of conversation analysis (CA might have to offer the study of linguistic synonymy. It takes as a case study two items commonly held to be synonyms -'actually' and 'in fact'- and shows considerable differences between the two in their interactional implementation: they are implicated in the prosecution of differing courses of action. Such cases argue that it is analytically more profitable to consider what a lexical item does in the context of talk than what it means.

  12. A Comparative Comment on the Case Studies

    DEFF Research Database (Denmark)

    Kjeldsen, Christian Christrup; Ley, Thomas; Jensen, Niels Rosendal;

    2012-01-01

    Denne konklusion sammenfatter hovedtrækkene af de gennemførte case studies i WorkAble-projektet. Vigtige pointer er, at unge på tværs af de forskellige case studies har vanskeligt ved at blive hørt og taget alvorligt. I stedet spises de af med "realistisk vejledning" eller dårlige uddannelses- og...... arbejdstilbud. Konklusionen foreslår at give unge mere tid til at træffe de alvorlige valg vedr. deres fremtid ved at indføre et refugium, som i tankegang minder om Eriksons ungdomsmoratorium....

  13. Refined solution structure and backbone dynamics of 15N-labeled C12A-p8MTCP studied by NMR relaxation

    Energy Technology Data Exchange (ETDEWEB)

    Barthe, Philippe; Chiche, Laurent; Declerck, Nathalie; Delsuc, Marc-Andre [Universite de Montpellier I, Faculte de Pharmacie, Centre de Biochimie Structurale, CNRS-UMR 9955, INSERM-U414 (France); Lefevre, Jean-Francois [Universite Louis Pasteur, CNRS UPR-9003, ESBS (France); Malliavin, Therese [Universite de Montpellier I, Faculte de Pharmacie, Centre de Biochimie Structurale, CNRS-UMR 9955, INSERM-U414 (France); Mispelter, Joel [Centre Universitaire Bat 112, INSERM-U350, Institut Curie, Biologie (France); Stern, Marc-Henri [Hopital Saint-Louis, Unite INSERM-U462 (France); Lhoste, Jean-Marc; Roumestand, Christian [Universite de Montpellier I, Faculte de Pharmacie, Centre de Biochimie Structurale, CNRS-UMR 9955, INSERM-U414 (France)

    1999-12-15

    MTCP1 (for Mature-T-Cell Proliferation) was the first gene unequivocally identified in the group of uncommon leukemias with a mature phenotype. The three-dimensional solution structure of the human p8{sup MTCP} protein encoded by the MTCP1 oncogene has been previously determined by homonuclear proton two-dimensional NMR methods at 600 MHz: it consists of an original scaffold comprising three {alpha}-helices, associated with a new cysteine motif. Two of the helices are covalently paired by two disulfide bridges, forming an {alpha}-hairpin which resembles an antiparallel coiled-coil. The third helix is orientated roughly parallel to the plane defined by the {alpha}-antiparallel motif and appears less well defined. In order to gain more insight into the details of this new scaffold, we uniformly labeled with nitrogen-15 a mutant of this protein (C12A-p8{sup MTCP1}) in which the unbound cysteine at position 12 has been replaced by an alanine residue, thus allowing reproducibly high yields of recombinant protein. The refined structure benefits from 211 additional NOEs, extracted from {sup 15}N-edited 3D experiments, and from a nearly complete set of {phi} angular restraints allowing the estimation of the helical content of the structured part of the protein. Moreover, measurements of {sup 15} N spin relaxation times and heteronuclear {sup 15} N{sup 1}HNOEs provided additional insights into the dynamics of the protein backbone. The analysis of the linear correlation between J(0) and J({omega}) was used to interpret relaxation parameters. It appears that the apparent relative disorder seen in helix III is not simply due to a lack of experimental constraints, but associated with substantial contributions of sub-nanosecond motions in this segment.

  14. The Danish National Case Study Report

    DEFF Research Database (Denmark)

    Brodersen, Søsser; Jørgensen, Michael Søgaard

    and science through co-operation with Science Shops as a mediator between universities and civil society. The Danish national case study report analyses three projects carried out through the Science Shops at DTU and RUC. One case is a co-operation between two DTU students and an NGO, whom is working towards...... that all three NGO’s have used the results and findings to try influencing the societal discourses, and that the results and findings have helped two of the NGOs to gain influence. The analysis further shows that this influence seems to depend on the ability of the NGOs to build alliances with other actors......This report is the Danish case study report in the EU-financed project INTERACTS, which analyses experience and expectations to the interaction between NGOs, Science Shops and universities. The report analyses potentials and barriers to NGO’s and similar civil society groups’ use of research...

  15. Necrotizing Fasciitis: A Study of 48 Cases.

    Science.gov (United States)

    Singh, Gurjit; Bharpoda, Pragnesh; Reddy, Raghuveer

    2015-12-01

    Necrotizing fasciitis represents a group of highly lethal infections characterized by rapidly progressing inflammation and necrosis. The aim of the study was to analyze the clinical profile, microbial flora, and predisposing risk factors in patients with necrotizing fasciitis. Lastly, we aimed to formulate a protocol for management of necrotizing fasciitis. Forty-eight cases of necrotizing fasciitis patients who reported to our hospital between April 2007 and September 2009 were included in the study. The commonest predisposing factors were age greater than 50 years (58 % cases) and diabetes mellitus (52 % cases). The commonest site involved was extremity (70.8 %). Majority of infections were polymicrobial (87.5 %). Repeated aggressive debridement was the commonest surgical procedure performed. Early and aggressive surgical debridement, often in multiple sittings, supplemented by appropriate antibiotics and supportive therapy, forms the key to a successful outcome in necrotizing fasciitis.

  16. DNA cleavage at the AP site via β-elimination mediated by the AP site-binding ligands.

    Science.gov (United States)

    Abe, Yukiko S; Sasaki, Shigeki

    2016-02-15

    DNA is continuously damaged by endogenous and exogenous factors such as oxidation and alkylation. In the base excision repair pathway, the damaged nucleobases are removed by DNA N-glycosylase to form the abasic sites (AP sites). The alkylating antitumor agent exhibits cytotoxicity through the formation of the AP site. Therefore blockage or modulation of the AP site repair pathway may enhance the antitumor efficacy of DNA alkylating agents. In this study, we have examined the effects of the nucleobase-polyamine conjugated ligands (G-, A-, C- and T-ligands) on the cleavage of the AP site. The G- and A-ligands cleaved DNA at the AP site by promoting β-elimination in a non-selective manner by the G-ligand, and in a selective manner for the opposing dT by the A-ligand. These results suggest that the nucleobase-polyamine conjugate ligands may have the potential for enhancement of the cytotoxicities of the AP site.

  17. Microbial study of meningitis and encephalitis cases.

    Science.gov (United States)

    Selim, Heba S; El-Barrawy, Mohamed A; Rakha, Magda E; Yingst, Samuel L; Baskharoun, Magda F

    2007-01-01

    Meningitis and/or encephalitis can pose a serious public health problem especially during outbreaks. A rapid and accurate diagnosis is important for effective earlier treatment. This study aimed to identify the possible microbial causes of meningitis and/or encephalitis cases. CSF and serum samples were collected from 322 patients who had signs and symptoms suggestive of meningitis and/or encephalitis. Out of 250 cases with confirmed clinical diagnosis, 83 (33.2%) were definitely diagnosed as bacterial meningitis and/or encephalitis cases (by using CSF culture, biochemical tests, latex agglutination test, and CSF stain), 17 (6.8%) were definitely diagnosed as having viral causes ( by viral isolation on tissue culture, PCR and ELISA), and one (0.4%) was diagnosed as fungal meningitis case (by India ink stain, culture, and biochemical tests). Also, there was one encephalitis case with positive serum ELISA IgM antibodies against Sandfly scilian virus. N. meningitidis, S. pneumonia and M. tuberculosis were the most frequently detected bacterial agents, while Enteroviruses, herpes simplex viruses and varicella zoster viruses were the most common viral agents encountered. Further studies are needed to assess the role of different microbial agents in CNS infections and their effective methods of diagnosis.

  18. STUDY OF 200 CASES OF PLEURAL FLUID

    Directory of Open Access Journals (Sweden)

    Ramakrishna R

    2016-09-01

    Full Text Available BACKGROUND We have studied 200 patients of pleural fluid presenting to our tertiary care centre. Presence of cases of pleural fluid is a common presentation both in pulmonary and extrapulmonary diseases. We analysed the patients having both exudates and transudates and studied the results. MATERIALS AND METHODS We selected patients above 20 years of age and classified the patients with pleural fluid as having transudates and exudates. We studied the causes of transudates and exudates. A total of 200 patients are studied in this prospective study. Diagnosis of pleural exudates is made on the basis of Light’s criteria, chest x-ray, pleural fluid analysis, CT scan in selected patients, sputum examination, bronchoscopy and bronchial washings. Moribund and non-cooperative patients and HIV positives were excluded from the study. RESULTS Among the 200 patients, 91% have exudates. 9% have transudates by Light’s criteria. Tuberculosis is the commonest cause of effusions (64.83% followed by malignancy (13.73% and sympneumonic or parapneumonic effusions (9.89%. Pleural effusions occurred predominantly in males. Prevalence of diabetes Mellitus among cases of tuberculous pleural effusions is 13.56%. Tuberculous effusions are predominantly right-sided. CONCLUSION Predominant cases of pleural fluid are exudates. Commonest cause of pleural effusion is Tuberculosis followed by malignancy both pulmonary and extrapulmonary and sym. and parapneumonic effusions. Prevalence of Diabetes among Tuberculous pleural effusion cases is more or less same as in general population. Cough, expectoration fever, chest pain and breathlessness are the common symptoms occurring in three fourths of the patients of tuberculous pleural effusion. Most of the cases of Tuberculous effusion are above 30 years of age. In the diagnosis of tuberculous pleural effusion, Pleural fluid ADA is very important. Pleural fluid cytology, pleural biopsy, bronchoscopy, bronchial washings and sputum

  19. Aerospace Mechanisms and Tribology Technology: Case Study

    Science.gov (United States)

    Miyoshi, K.

    1999-01-01

    This paper focuses attention on tribology technology practice related to vacuum tribology. A case study describes an aspect of a real problem in sufficient detail for the engineer and scientist to understand the tribological situation and the failure. The nature of the problem is analyzed and the tribological properties are examined.

  20. Aerospace Mechanisms and Tribology Technology: Case Studies

    Science.gov (United States)

    Miyoshi, Kazuhisa

    1999-01-01

    This chapter focuses attention on tribology technology practice related to vacuum tribology and space tribology. Two case studies describe aspects of real problems in sufficient detail for the engineer and the scientist to understand the tribological situations and the failures. The nature of the problems is analyzed and the range of potential solutions is evaluated. Courses of action are recommended.

  1. Case Study of Home-School Visits

    Science.gov (United States)

    Aguerrebere, Yolanda

    2009-01-01

    This case study evaluated one site of a California teacher home visit program. Home visits have been an important means of connecting families and schooling. In 1999, California inaugurated a statewide home visit program to promote effective partnership between home and school for low-achieving schools. At this site, families in 3 kindergarten…

  2. Learning Team Strategies: Soccer Case Studies

    NARCIS (Netherlands)

    Wiering, M.A.; Salustowicz, R.P.; Schmidhuber, J.

    1998-01-01

    We use simulated soccer to study multiagent learning. Each team's players (agents) share action set and policy, but may behave differently due to position-dependent inputs. All agents making up a team are rewarded or punished collectively in case of goals. We conduct simulations with varying t

  3. Learning Machine Learning: A Case Study

    Science.gov (United States)

    Lavesson, N.

    2010-01-01

    This correspondence reports on a case study conducted in the Master's-level Machine Learning (ML) course at Blekinge Institute of Technology, Sweden. The students participated in a self-assessment test and a diagnostic test of prerequisite subjects, and their results on these tests are correlated with their achievement of the course's learning…

  4. Physics Courses--Some Suggested Case Studies

    Science.gov (United States)

    Swetman, T. P.

    1972-01-01

    To communicate the relevance and excitement of science activity to students, the use of more imaginative, and even openly speculative, case studies in physics courses is suggested. Some useful examples are Magnetic Monopoles, Constants, Black Holes, Antimatter, Zero Mass Particles, Tachyons, and the Bootstrap Hypothesis. (DF)

  5. Climate wise case study compendium: Report 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-01

    This case study compendium is one of several Climate Wise tools available to help interested companies identify cost-effective options. Climate Wise, a private-public partnership program, is a key Federal initiative to return greenhouse gas emissions to 1990 levels by 2000.

  6. Marietta Celebration of Unity Case Study.

    Science.gov (United States)

    Philbin, Meg; Phillips, Rebecca

    This case study concerns the forming of a Marietta, Ohio unity committee, entitled Citizens for Social and Racial Justice, in response to the local Ku Klux Klan's (KKK) request for a parade permit in order to demonstrate against blacks in this city. Marietta, the county seat of Washington County, Ohio, has a population composed of both white and…

  7. Gifted Teenagers with Problems: Three Case Studies.

    Science.gov (United States)

    Monaco, Theresa; Goodner, Jane

    Case studies are presented of three gifted students, indicating the social and academic problems which are standing in the way of their potential development. The students include a Vietnamese-American ninth-grade girl who has difficulty with English and does not feel accepted by other students, an underachieving seventh grade boy who speaks out…

  8. Sustainability in Housing: A Curriculum Case Study.

    Science.gov (United States)

    Parrott, Kathleen; Emmel, Joann M.

    2001-01-01

    Explores the influence of environmental issues on the field of housing, from the perspective of sustainable housing. Presents a case study of the development of a college course to address these issues by integrating energy management, air quality, water quality, and waste management. (Author)

  9. A Codesign Case Study in Computer Graphics

    DEFF Research Database (Denmark)

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based...

  10. WP6 - The Ag2020 Case Studies

    DEFF Research Database (Denmark)

    Hansen, Jens G; Borch, Kristian; Trombi, Giacomo;

    2010-01-01

    of the Future are presented. Finally, in section 1.4, is described the structure of the present report,which is firmly followed by the four case studies involved in the Project, namely the Rhodope Mountainous region in Bulgaria (CS1), The Kastelli region (Herakleion nomos) in Greece (CS2), the Central Denmark...

  11. LCA – Unique and Controversial Case Studies

    Science.gov (United States)

    This session will focus on case studies and applications that have a unique or controversial aspect. Some of the most recent topics that seem to have significant interest include: LCA-based product declarations, LCA-based standards, LCA-based labels, alternative energy, agricul...

  12. Recurrent perinatal loss: a case study.

    Science.gov (United States)

    Kavanaugh, K; Robertson, P A

    1999-01-01

    To date, investigators have not demonstrated a clear relationship between a parent's history of prior perinatal losses and intensity of grief response following a subsequent perinatal loss. Examining this relationship for low-income, African-American parents is important because they are a vulnerable population due to the high incidence of perinatal mortality in Blacks and their other life stressors that can impact on grief response and caring needs. The purpose of this case study was to examine the impact of recurrent perinatal loss on a low-income African-American parent. The research design for this study was case report, using interview data collected from a mother who had recently experienced her fourth perinatal loss, which occurred at twenty-five weeks of gestation. Transcripts from two open-ended interviews were analyzed. The theoretical framework used to guide analysis of this case study was Lazarus and Folkman's stress and coping theory. Results demonstrated that the prior perinatal losses did not appear as critical components of the way the mother responded to her most recent loss. Instead, perception of the care she received from healthcare providers and how that care related to her experiences with her one living child who was born at the same gestational age was an important determinant in how she responded to her loss. The results of this case study demonstrate the importance assessing a person's perception of their experience and those factors which contribute to the way they respond.

  13. The Interim Superintendent: A Case Study

    Science.gov (United States)

    Bigham, Gary; Nix, Susan J.

    2011-01-01

    Considering the vitally important role that the superintendent plays in the overall functioning and wellbeing of any school district, the filling of that position should never be done in haste. Due to the importance of this process and the time it requires, school districts often employ an interim superintendent. In this single case study, one…

  14. Biliteracy, Spelling, and Writing: A Case Study

    Science.gov (United States)

    Midgette, Ekaterina; Philippakos, Zoi A.

    2016-01-01

    The overall purpose of this case study is to examine biliteracy and its effects on a young child's orthographic and writing growth. The analysis of the kindergartener's spelling development and compositional growth in reference to both language systems indicates that biliteracy had a positive effect on the student's acquisition of English…

  15. Makerspaces in Engineering Education: A Case Study

    DEFF Research Database (Denmark)

    Jensen, Lasse Skovgaard; Özkil, Ali Gürcan; Mougaard, Krestine

    2016-01-01

    it by opening makerspaces and adopting elements of the Maker Movement in their offerings. This paper investigates how university driven makerspaces can affect engineering design and product development education trough a case study. We provide our findings based on interviews and data collected from educators...

  16. Career Development of Black Males: Case Studies.

    Science.gov (United States)

    Chung, Y. Barry; Baskin, Monica L.; Case, Andrew B.

    1999-01-01

    Case studies of six black males explored background, school and work experiences, and career issues. These themes emerged: fathers' financial support and role modeling influenced career development; other male role models affected aspirations; social, especially parental support for education and careers influenced decision making; and racism…

  17. Helping Adolescents in Crisis: A Case Study.

    Science.gov (United States)

    Hamilton-Obaid, Beatrice

    1989-01-01

    Addresses problem of adolescent suicide by developing five stages (suicidal signs, establishing rapport, making referral, constructive actions, and self-management) that may be used to help adolescents in distress. Uses five stages in case study to demonstrate the roles played by teacher, friend, and parents in helping adolescent through a crisis.…

  18. New Lives: Some Case Studies in Minamata.

    Science.gov (United States)

    Tsurumi, Kazuko

    Three case studies of young Japanese adults who fell ill with Minamata disease (a form of methyl-mercury poisoning) are presented and the adjustment of the individuals to the disease is analyzed in terms of a model of creativity. The model distinguishes three types of creativity: identificational (in which one identifies with old ideas and…

  19. ESL and Digital Video Integration: Case Studies

    Science.gov (United States)

    Li, J., Ed.; Gromik, N., Ed.; Edwards, N., Ed.

    2013-01-01

    It should come as no surprise that digital video technology is of particular interest to English language learners; students are drawn to its visual appeal and vibrant creative potential. The seven original case studies in this book demonstrate how video can be an effective and powerful tool to create fluid, fun, interactive, and collaborative…

  20. Eastern's Employee Communication Crisis: A Case Study.

    Science.gov (United States)

    Saunders, Martha

    1988-01-01

    Explores communication behaviors and reactions of employees during crisis periods, using a qualitative case study of Eastern Airlines pilots. Finds that useful theories for crisis communication can be developed only after sufficient inquiry into the communication needs and behaviors of message receivers. (MS)

  1. Interdisciplinary Student Teams Projects: A Case Study

    Science.gov (United States)

    Kruck, S. E.; Teer, Faye P.

    2009-01-01

    In today's organizations team work has become an integral part of the day-to-day routine. For this reason, University professors are including group projects in many courses. In such group assessments, we advocate the use of interdisciplinary teams, where possible. As a case study, we report an interdisciplinary group technical project with…

  2. Nanomaterial Case Studies: Nanoscale Titanium Dioxide ...

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental assessment approach that combines a product life cycle framework with the risk assessment paradigm. The document does not draw conclusions about potential risks. Rather, the case studies are intended to help identify what needs to be known in order to conduct a comprehensive environmental assessment of the potential risks related to nano-TiO2. This draft document is part of a process that will inform the development of EPA’s research strategy to support nanomaterial risk assessments. The complex properties of various nanomaterials make evaluating them in the abstract or with generalizations difficult if not impossible. Thus, this document focuses on two specific uses of nano-TiO2, as a drinking water treatment and as topical sunscreen. These case studies do not represent completed or even preliminary assessments; rather, they present the structure for identifying and prioritizing research needed to support future assessments.

  3. It's Not Funny: A Case Study

    Science.gov (United States)

    Méndez-Morse, Sylvia

    2015-01-01

    This case study may be used with personnel supervision, school law, and other school leadership courses. It describes the behavior and actions of one teacher toward another. Student discussions can focus on supervision, workplace mobbing, workplace bullying, as well as sexual harassment. Students should focus on a school leader's role in such…

  4. Lifelong Learning in SMEs: A Case Study.

    Science.gov (United States)

    Holden, Rick; Smith, Vikki; Devins, Dave

    2002-01-01

    Learning centers using information-communications technologies were established in three British industrial estates. A case study of one organization shows the center contributed to lifelong learning and enhanced information technology training and employee confidence. Transfer of training and productivity improvements were not as clear. (Contains…

  5. Makerspaces in Engineering Education: A Case Study

    DEFF Research Database (Denmark)

    Jensen, Lasse Skovgaard; Özkil, Ali Gürcan; Mougaard, Krestine

    2016-01-01

    it by opening makerspaces and adopting elements of the Maker Movement in their offerings. This paper investigates how university driven makerspaces can affect engineering design and product development education trough a case study. We provide our findings based on interviews and data collected from educators...... engineering design education....

  6. Fraternization in Accounting Firms: A Case Study

    Science.gov (United States)

    Heinze, Tim; Kizirian, Tim; Leese, Wallace

    2004-01-01

    This case study sheds light on how to avoid risks caused by manager-subordinate dating relationships (fraternization) such as employee misunderstandings, retaliation charges, favoritism complaints, wrongful termination lawsuits, and sexual harassment lawsuits, as well as associated ethical risks. Risk avoidance can be accomplished through a better…

  7. Molecular Basis for Enhancement of the Meiotic DMCI Recombinase by RAD51AP1

    Energy Technology Data Exchange (ETDEWEB)

    Dray, Eloise; Dunlop, Myun Hwa; Kauppi, Liisa; San Filippo, Joseph San; Wiese, Claudia; Tsai, Miaw-Sheue; Begovic, Sead; Schild, David; Jasin, Maria; Keeney, Scott; Sung, Patrick

    2010-11-05

    Homologous recombination is needed for meiotic chromosome segregation, genome maintenance, and tumor suppression. RAD51AP1 (RAD51 Associated Protein 1) has been shown to interact with and enhance the recombinase activity of RAD51. Accordingly, genetic ablation of RAD51AP1 leads to enhanced sensitivity to and also chromosome aberrations upon DNA damage, demonstrating a role for RAD51AP1 in mitotic homologous recombination. Here we show physical association of RAD51AP1 with the meiosis-specific recombinase DMC1 and a stimulatory effect of RAD51AP1 on the DMC1-mediated D-loop reaction. Mechanistic studies have revealed that RAD51AP1 enhances the ability of the DMC1 presynaptic filament to capture the duplex DNA partner and to assemble the synaptic complex, in which the recombining DNA strands are homologously aligned. We also provide evidence that functional co-operation is dependent on complex formation between DMC1 and RAD51AP1, and that distinct epitopes in RAD51AP1 mediate interactions with RAD51 and DMC1. Finally, we show that RAD51AP1 is expressed in mouse testes, and that RAD51AP1 foci co-localize with a subset of DMC1 foci in spermatocytes. These results suggest that RAD51AP1 also serves an important role in meiotic homologous recombination.

  8. Avio case study: the MRO process

    Science.gov (United States)

    Corallo, Angelo; Dimartino, Angelo; Errico, Fabrizio; Giangreco, Enza

    This chapter presents the case study of the Avio Brindisi plant where a profound process of change has been in progress for a number of years. We use the TEKNE Project methodology of change to analyze the different aspects of the case, highlighting the firm's strategic, organizational and technological characteristics and the environment it operates in. In particular, we envisage a change in the plant's business model in response to the expansion of its client segments and a potential new approach to MRO operations based on advanced fleet management practices that would radically change the firm's organization and value network with respect to its MRO service offering, thereby yielding extensive global market opportunities.

  9. Mobile Technologies Adoption: An Exploratory Case Study

    Institute of Scientific and Technical Information of China (English)

    CHU Yan; HUANG Lihua

    2008-01-01

    Based on the theory of task-technology fit and literature review of mobile technology acceptance, a research model is presented based on the features of mobile technologies and the actual usage of mobile applications in business environments, which identifies the characteristics of mobile applications and fitting tasks. An exploratory case is studied to understand how ABC Company, Hong Kong, utilizes mobile selling applications in their sales management process. This study gives some managerial suggestions for enterprises to successfully use mobile applications.

  10. Empathy Development Through Case Study and Simulation.

    Science.gov (United States)

    Mennenga, Heidi A; Bassett, Susan; Pasquariello, Libby

    2016-01-01

    Because empathy is integral to the nurse-patient relationship, nurse educators are challenged to explore teaching strategies that may aid in the development of empathy among students. The purpose of this study was to determine whether consistent exposure to a single patient through case study and simulation had an impact on empathy levels in senior-level baccalaureate nursing students. Results provide interesting conclusions for faculty members and offer a basis for ongoing discussion.

  11. CAT: A CASE STUDY OF GRE

    Institute of Scientific and Technical Information of China (English)

    WangZe; ChenJiliang

    2004-01-01

    The Computer Adaptive Testing (CAT) has developedsuccessfully with its adoption by testing agencies. The authors ofthis paper point out the advantages and disadvantages of CATsand then take GRE as a case study to probe into the scoringalgorithm in CAT. By analyzing some typical score reports ofcomputer-adaptive GRE General Test, they study some majorfactors affecting the final score such as the percentage ofcorrectness and difficulty levels.

  12. On AP-property of Function Spaces

    Institute of Scientific and Technical Information of China (English)

    SHEN Rong-xin

    2012-01-01

    In this paper,it is discussed the AP-property of function spaces.We prove that for any compact network α for a space X which is closed under finite unions,(1) if Cα(X) is an AP-space and X is paracompact,then X is a Hurewicz space; (2) if Cα (X) is an AP-space which has countable tightness,then Cα(X) is discretely generated.

  13. PANCYTOPENIA - A STUDY OF 58 CASES

    Directory of Open Access Journals (Sweden)

    Rajesh

    2013-11-01

    Full Text Available Pancytopenia means decrease in all three cell lines. It is the striking feature of of many illness ranging from megaloblastic anaemia to leukemias. The underlying pathology of pancytopenia will determine the management and prognosis. OB JECTIVE: To identify the various causes of Pancytopenia. MATERIALS AND METHODS: The present study was undertaken at A Private Lab. RESULTS: 58 cases were studied, 30males and 28 females with age ranging from 3 yrs to 90 yrs. Most of the cases presented wit h generalized weakness, followed by pallor, hepatosplenomegaly and bleeding manifestations. CONCLUSION: The present study was helpful in understanding the various causes of diseases process with bone marrow aspiration done in few of the pancytopenic patien ts along with support of biochemical investigations which were helpful in planning further investigations and management.

  14. Dieulafoy's lesion: A case series study

    Institute of Scientific and Technical Information of China (English)

    RS Walmsley; Yuk-Tong Lee; Joseph JY Sung

    2005-01-01

    AIM: Dieulafoy's lesion (DL) accounts for 1-5.8% of cases of acute upper gastrointestinal bleeding (GIB). Its mortality is high, approaching 20%, despite recent advances in endoscopic therapy. We aimed to report our experience in the treatment of DL.METHODS: A retrospective case study of all patients with DL between January 1993 and January 2003 was done. Characteristics, treatment methods, success rates and 30-d mortality of the patients were analyzed. RESULTS: Thirty-six patients were noted to have DL in the study period. Thirty-three records were available for assessment in which 35 DL were identified. The median age of the patients was 67 years with male to female ratio of 5.6:1. Significant comorbidities existed in 69% of the patients. Eighty-nine percent of the DL was found at first endoscopy, three DL at laparotomy. Significant coexistent endoscopic findings existed in 23%. Hemostasis was achieved in 88% by using adrenaline injection, or in combination with heater probe application at first endoscopy. Four cases had re-bleeding, all were successfully treated endoscopically. The 30-d mortality rate was 23%.CONCLUSION: Successful endoscopic hemostasis could be achieved in 100% of cases of DL. The overall mortality may still remain high, mainly due to the comorbidities and age of these patients.

  15. The Pendulum A Case Study in Physics

    CERN Document Server

    Baker, Gregory L

    2005-01-01

    The pendulum: a case study in physics is a unique book in several ways. Firstly, it is a comprehensive quantitative study of one physical system, the pendulum, from the viewpoint of elementary and more advanced classical physics, modern chaotic dynamics, and quantum mechanics. In addition, coupled pendulums and pendulum analogs of superconducting devices are also discussed. Secondly, this book treats the physics of the pendulum within a historical and cultural context,showing, for example, that the pendulum has been intimately connected with studies of the earth's density, the earth's motion,

  16. Necrotizing nocardial scleritis after combined penetrating keratoplasty and phacoemulsification with intraocular lens implantation: a case report and review of the literature Esclerite necrosante por Nocardia após ceratoplastia penetrante e facoemulsificação com implante de lente intra-ocular: caso clínico e revisão de literatura

    Directory of Open Access Journals (Sweden)

    Jerome Charles Ramos-Esteban

    2007-03-01

    Full Text Available We report the history and clinical presentation of an 88-year-old female with Fuchs dystrophy who developed an acute anterior necrotizing scleritis in her left eye 23 months after an uncomplicated combined penetrating keratoplasty and phacoemulsification with intraocular lens implantation which progressed to slceral perforation with uveal prolapses. The patient underwent a complete systemic work-up for both autoimmune and infectious causes of scleritis. Surgical specimens of the area of scleral perforation were sent for histology and microbiologic studies. Analysis of surgical specimens revealed the presence of culture-proven Nocardia asteroides as a causative agent for the patient's scleral perforation. Results of her systemic autoimmune work-up were not conclusive. Successful treatment with tectonic scleral reinforcement with donor corneal tissue and preserved pericardium, oral and topical trimethoprim-sulfamethoxazole and topical amikacin salvaged the globe and increased vision. The patient's final best-corrected visual acuity sixteen months after her last operation remains 20/70. Prompt surgical intervention with submission of appropriate specimens for pathological diagnosis and microbiology, along with consultation with rheumatologic and infectious disease specialists, are mandatory to minimize visual loss in cases of suspected infectious necrotizing scleritis.Relato de caso de esclerite necrosante aguda, evoluindo para perfuração escleral com prolapso uveal, 23 meses após procedimento de ceratoplastia penetrante e facoemulsificação com implante de lente intra-ocular no olho esquerdo sem intercorrências.A paciente foi submetida à avaliação completa auto-imune para esclerite. Biópsia da área de perfuração escleral foi encaminhada para avaliação patológica e microbiológica. Análise de material cirúrgico revelou presença de cultura proveniente de Nocardia asteroides como agente causal da perfuração escleral. Resultados de

  17. Management & Communication: Project Management Case Study

    CERN Document Server

    Nathalie Dumeaux

    2004-01-01

    We are pleased to announce the recent launch of a new workshop on Project Management. This is designed for People with budgetary, scheduling and/or organizational responsibilities in a project or a sub-project. The objectives through a management case study specially suited to CERN are: to become familiar with modern management techniques in use for structuring, planning, scheduling, costing and progress monitoring of a project or a sub-project. to understand in-depth issues associated with Deliverable-oriented Project Management, Earned Value Management, Advanced Project Cost Engineering and Project Risk Management. The full description of this workshop can be found here. The next session will be held on 8 October 2004. If you are interested in this workshop, please contact Nathalie Dumeaux, email or 78144. Programme of Seminars October to December 2004 Situation : 21.09.2004 Séminaires bilingues Dates Jours Places disponibles Project Management Case study 8 October 1 oui Intr...

  18. Case studies in government procurement fraud

    OpenAIRE

    Gayton, James R. S.

    2004-01-01

    Approved for public release, distribution is unlimited MBA Professional Report The purpose of this research is to provide guidance that will increase awareness and facilitate class discussions on ethical situations that contracting officers are exposed to during their business relationships with contracting firms. The cases explore the specifics of individual incidents of ethical and procedural procurement violations. Additionally, this study provides conclusions and recommendations tha...

  19. Web Fuzzy Clustering and a Case Study

    Institute of Scientific and Technical Information of China (English)

    LIU Mao-fu; HE Jing; HE Yan-xiang; HU Hui-jun

    2004-01-01

    We combine the web usage mining and fuzzy clustering and give the concept of web fuzzy clustering, and then put forward the web fuzzy clustering processing model which is discussed in detail. Web fuzzy clustering can be used in the web users clustering and web pages clustering. In the end, a case study is given and the result has proved the feasibility of using web fuzzy clustering in web pages clustering.

  20. RECURRENT PERINATAL LOSS: A CASE STUDY*

    OpenAIRE

    1999-01-01

    To date, investigators have not demonstrated a clear relationship between a parent’s history of prior perinatal losses and intensity of grief response following a subsequent perinatal loss. Examining this relationship for low-income, African-American parents is important because they are a vulnerable population due to the high incidence of perinatal mortality in Blacks and their other life stressors that can impact on grief response and caring needs. The purpose of this case study was to exam...

  1. Teaching microbiological food safety through case studies

    OpenAIRE

    Florence Dubois-Brissonnet; Laurent Guillier; Murielle Naïtali

    2015-01-01

    Higher education students usually ask for more training based on case studies. This was addressed by designing a specific food safety module (24 hours) in which students were shown how to predict microbiological risks in food products i.e. they were asked to determine product shelf-life according to product formulation, preservation methods and consumption habits using predictive microbiology tools. Working groups of four students first identified the main microbiological hazards associated w...

  2. A warehouse design decision model: case study

    OpenAIRE

    Geraldes, Carla A. S. (Ed.); Carvalho, Maria do Sameiro; Pereira, Guilherme

    2008-01-01

    Today’s competitive and volatile market requires flexibility, quality and efficiency from the logistics operations. In this context, warehouses are an important link of the logistic chain and warehouse management plays an important role over customer's service. Throughout this work we analyze a mathematical model aiming to support warehouse management decisions. A case study is used for that purpose and the model jointly identifies product allocation to the functional areas in the warehouse, ...

  3. Concentrated Photo Voltaics (CPV: a case study

    Directory of Open Access Journals (Sweden)

    Centro S.

    2015-01-01

    Full Text Available Concentrated PhotoVoltaic (CPV, among green energy solutions, nowadays has the ambition to reach grid-parity without subside. CPV substitutes large areas of expensive semiconductor solar cells, with concentrating optics made of cheap materials. Moreover the cells that are suitable for CPV exhibits an unprecedented efficiency and their technology is progressing every year. A case study project, TwinFocus®, will be presented in detail.

  4. BOOK REVIEW: Case Studies in Knowledge Management

    OpenAIRE

    BOYACI, Reviewed By Dr. Adnan

    2005-01-01

    161Case Studies in Knowledge ManagementEdited by Murray JennexHersley: PA: Idea Group, 2005, pp. 372, ISBN 1-59140-352-9Reviewed by Dr. Adnan BOYACIAnadolu UniversityEskişehir-TurkeyKnowledge management (KM) as a structured system and the way to the effectiveness isrelatively new field for the contemporary organizations functioning in different andcompetitive domain of public and private sectors in terms of getting optimal effectivenessunderlined by the concepts such as quality, productivity…...

  5. Case studies of soil in art

    Science.gov (United States)

    Feller, C.; Landa, E. R.; Toland, A.; Wessolek, G.

    2015-08-01

    The material and symbolic appropriations of soil in artworks are numerous and diverse, spanning many centuries and artistic traditions, from prehistoric painting and ceramics to early Renaissance works in Western literature, poetry, paintings, and sculpture, to recent developments in film, architecture, and contemporary art. Case studies focused on painting, installation, and film are presented with the view of encouraging further exploration of art about, in, and with soil as a contribution to raising soil awareness.

  6. Global Hawk Systems Engineering. Case Study

    Science.gov (United States)

    2010-01-01

    as Aurora and Grob. Fourteen teams responded. The bids submitted covered a wide-range of size and performance for a $10 million UFP, causing the...Delos Reyes , 95th Air Base Wing Public Affairs, 1 December 2006 Roll Out of Firs Production Block 10 Global Hawk Systems Engineering Case Study...Delos Reyes , 95th DoD News Briefing, June 28, 1995 Air Base Wing Public Affairs, December 1, 2006 Edwards Test Production Global Hawk for Possible

  7. The Graduate Experience: Living and Studying Abroad (A Case Study

    Directory of Open Access Journals (Sweden)

    Rosario Hernández Castañeda

    2008-11-01

    Full Text Available This article is a qualitative case study describing the experience of Angélica an international graduate student from Latin America, who received her doctorate at the University of New Mexico in the United States. Her case demonstrated how administrators and faculty learn about the experience and struggles endured by international students, especially those who learned English a short time before admission to graduate studies. While a single case is understandably idiographic in nature and inevitably requires a larger sample, from the analysis of Angélica’s case and the analysis of the relevant literature common topics emerged persuading me to conclude that the issues that commonly impact the life of international students have to do with: 1 second language problems; 2 the quality of academic advisement received; 3 the availability of financial support; 4 the level of integration into their academic program; and 5 the level of cultural adjustment in their host country.

  8. Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study in the Asia-Pacific Region (MUSIC OS-AP: Design of a multinational, prospective, observational study examining the impact of gastrointestinal events on osteoporosis management in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Ankita Modi

    2015-12-01

    Conclusions: The results of MUSIC OS-AP will highlight the association of gastrointestinal events with patient-reported outcomes among postmenopausal women with osteoporosis and elucidate physicians' management of gastrointestinal events among this patient population in the Asia-Pacific region.

  9. Shuttle Transportation System Case-Study Development

    Science.gov (United States)

    Ransom, Khadijah

    2012-01-01

    A case-study collection was developed for NASA's Space Shuttle Program. Using lessons learned and documented by NASA KSC engineers, analysts, and contractors, decades of information related to processing and launching the Space Shuttle was gathered into a single database. The goal was to provide educators with an alternative means to teach real-world engineering processes and to enhance critical thinking, decision making, and problem solving skills. Suggested formats were created to assist both external educators and internal NASA employees to develop and contribute their own case-study reports to share with other educators and students. Via group project, class discussion, or open-ended research format, students will be introduced to the unique decision making process related to Shuttle missions and development. Teaching notes, images, and related documents will be made accessible to the public for presentation of Space Shuttle reports. Lessons investigated included the engine cutoff (ECO) sensor anomaly which occurred during mission STS-114. Students will be presented with general mission infom1ation as well as an explanation of ECO sensors. The project will conclude with the design of a website that allows for distribution of information to the public as well as case-study report submissions from other educators online.

  10. National Environmental Change Information System Case Study

    Science.gov (United States)

    Goodman, S. J.; Ritschard, R.; Estes, M. G., Jr.; Hatch, U.

    2001-01-01

    The Global Hydrology and Climate Center and NASA's Marshall Space Flight Center conducted a fact-finding case study for the Data Management Working Group (DMWG), now referred to as the Data and Information Working Group (DIWG), of the U.S. Global Change Research Program (USGCRP) to determine the feasibility of an interagency National Environmental Change Information System (NECIS). In order to better understand the data and information needs of policy and decision makers at the national, state, and local level, the DIWG asked the case study team to choose a regional water resources issue in the southeastern United States that had an impact on a diverse group of stakeholders. The southeastern United States was also of interest because the region experiences interannual climatic variations and impacts due to El Nino and La Nina. Jointly, with input from the DIWG, a focus on future water resources planning in the Apalachicola-Chattahoochee-Flint (ACF) River basins of Alabama, Georgia, and Florida was selected. A tristate compact and water allocation formula is currently being negotiated between the states and U.S. Army Corps of Engineers (COE) that will affect the availability of water among competing uses within the ACF River basin. All major reservoirs on the ACF are federally owned and operated by the U.S. Army COE. A similar two-state negotiation is ongoing that addresses the water allocations in the adjacent Alabama-Coosa-Tallapoosa (ACT) River basin, which extends from northwest Georgia to Mobile Bay. The ACF and ACT basins are the subject of a comprehensive river basin study involving many stakeholders. The key objectives of this case study were to identify specific data and information needs of key stakeholders in the ACF region, determine what capabilities are needed to provide the most practical response to these user requests, and to identify any limitations in the use of federal data and information. The NECIS case study followed the terms of reference

  11. Are clerical workers proletarian? A case study of the Australian Public Service.

    Science.gov (United States)

    Matheson, Craig

    2007-12-01

    This paper explores whether clerical workers have been proletarianized by using the Australian Public Service (APS) as a case study. It shows that before the late 1980s the market, work and status situations of APS clerks were predominantly proletarian since they were typified by limited career prospects, low skill requirements, restricted autonomy; low organizational status and estrangement from senior management. This proletarian class situation was reflected in an order taker's culture of informality, cynicism, hedonism and alienation. Since the late 1980s however technological change and workplace restructuring have markedly reduced the number of unskilled and lower paid jobs in the APS, thereby belying widespread predictions of deskilling. I conclude that proletarianization is more likely to have arisen from a decline in the status of clerical work during the course of the twentieth century rather than from a process of deskilling. Notwithstanding the fact that their class situations were predominantly proletarian, most clerks have identified as middle class. We can attribute this not only to the fact that their class situations differ from those of manual workers, as noted by Lockwood, but also to a widespread tendency to identify as middle class, the tendency of many female clerks to base their class identity on their husband's occupation and the fact that popular stereotypes tend to equate class with occupation. It is difficult to decide if clerks are proletarian since 1. Their class situations display a mixture of proletarian and middle-class characteristics 2. They exhibit diverse class identities, social origins, marriage partners and cultural attributes and 3. They occupy different positions on different aspects of inequality. We are therefore unable to allocate them en bloc to a single uniform class. I conclude that while a minority of clerks are proletarian most are better described as middle class.

  12. Prevention of aspiration pneumonia (AP) with oral care.

    Science.gov (United States)

    Tada, Akio; Miura, Hiroko

    2012-01-01

    AP is a major cause of morbidity and mortality in elderly patients, especially frail elderly patients. The aim of this article is to review effect of oral care, including oral hygiene and improvement of oral function, on the prevention of AP among elderly people in hospitals and nursing homes. There is now a substantial body of work studying the effect of oral care on the prevention of respiratory diseases. Oral hygiene, consisting of oral decontamination and mechanical cleaning by dental professionals, has resulted in significant clinical effects (decreased incidence of pneumonia and decreased mortality from respiratory diseases) in clinical randomized trials. Moreover, studies examining oral colonization by pneumonia pathogens have shown the effect of oral hygiene on eliminating these pathogens. In addition, swallowing training has been shown to improve the movement and function of swallowing-related muscles, also resulting in decreased incidence of pneumonia. These findings support the contention that oral care is effective in the prevention of AP.

  13. Case Study on Printed Matter in Denmark

    DEFF Research Database (Denmark)

    Larsen, Henrik Fred

    2012-01-01

    60 of these substances fulfill one or more of the criteria (e.g., CMR, EDS) for the REACH Annex XIV candidate list (Authorisation List). This case study presents the results of the mapping of chemical substitution candidates some of which may be relevant regarding accumulation of additives...... in 2006. A major part of the work has been mapping the presence of chemicals, which are the potential candidates for substitution (e.g., PBT, CMR, vPvB, EDS). The mapping comprises a combination of a literature study and an investigation of the actual (2007) presence of candidate substances at 15 Danish...

  14. Case study of isosurface extraction algorithm performance

    Energy Technology Data Exchange (ETDEWEB)

    Sutton, P M; Hansen, C D; Shen, H; Schikore, D

    1999-12-14

    Isosurface extraction is an important and useful visualization method. Over the past ten years, the field has seen numerous isosurface techniques published leaving the user in a quandary about which one should be used. Some papers have published complexity analysis of the techniques yet empirical evidence comparing different methods is lacking. This case study presents a comparative study of several representative isosurface extraction algorithms. It reports and analyzes empirical measurements of execution times and memory behavior for each algorithm. The results show that asymptotically optimal techniques may not be the best choice when implemented on modern computer architectures.

  15. Using Case Studies to Teach About Global Issues, Bali: A Case Study

    Science.gov (United States)

    Oswald, James M.

    1974-01-01

    The South Pacific island of Bali is used as a case study of overpopulation and food shortage. A brief description of the resources, the typical lifestyle of the Balinese farmer, and possible teaching techniques are given. (DE)

  16. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in ...

    Science.gov (United States)

    EPA announced the availability of the final report, Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen. This report is a starting point to determine what is known and what needs to be known about selected nanomaterials as part of a process to identify and prioritize research to inform future assessments of the potential ecological and health implications of these materials. Two specific applications of nanoscale titanium dioxide (nano-TiO2) are considered: (1) as an agent for removing arsenic from drinking water; and (2) as an active ingredient in topical sunscreen. These case studies are organized around a comprehensive environmental assessment (CEA) framework that combines a product life cycle perspective with the risk assessment paradigm. They are intended to help identify what may need to be known in order to conduct a comprehensive environmental assessment of the potential risks related to nano-TiO2. These “case studies” do not represent completed or even preliminary assessments, nor are they intended to serve as a basis for risk management decisions in the near term on these specific uses of nano TiO2. Rather, the intent is to use this document in developing the scientific and technical information needed for future assessment efforts.

  17. The case study of biomaterials and biominerals

    Science.gov (United States)

    Del Hoyo Martínez, Carmen

    2013-04-01

    The teaching of biomaterials as case study by on-line platform , susceptible to develop both individually and in groups, got different objectives proposed by the European Higher Education System, among which include: participate actively in the teaching-learning process by students, interpreting situations, adapt processes and solutions. It also improves oral and written communication, analytical skills and synthesis and also the ability to think critically. Biomaterials have their origin in biominerals. These are solid inorganic compounds of defined structure, consisting of molecular control mechanisms that operate in biological systems. Its main functions are: structural support, a reservoir of essential elements, sensors, mechanical protection and storage of toxic elements. Following the demand of materials compatible with certain functional systems of our body, developed biomaterials. Always meet the condition of biocompatibility. Should be tolerated by the body and do not provoke rejection. This involves a comprehensive study of physiological conditions and the anatomy of the body where a biomaterial has to be implemented. The possibility of generating new materials from biominerals has a major impact in medicine and other fields could reach as geology, construction, crystallography, etc. While the study of these issues is in its infancy today, can be viewed as an impact on the art and future technology. Planning case study that students would prepare its report for discussion in subgroups. Occurs then the pooling of individual analysis, joint case discussion and adoption by the subgroup of a consensual solution to the problem. The teacher as facilitator and coordinator of the final case analysis, sharing leads to group-wide class and said the unanimous decision reached by the students and gives his opinion on the resolution of the case. REFERENCES D.P. Ausubel. Psicología Educativa. Un punto de vista cognoscitivo. Trillas. Ed. 1983. E.W. Eisner. Procesos

  18. Terahertz applications in cultural heritage: case studies

    Science.gov (United States)

    Giovannacci, D.; Martos-Levif, D.; Walker, G. C.; Menu, M.; Detalle, V.

    2013-11-01

    Terahertz (THz) spectroscopy and imaging is a non-destructive, non-contact, non-invasive technology emerging as a tool for the analysis of cultural heritage. THz Time Domain Spectroscopy (TDS) techniques have the ability to retrieve information from different layers within a stratified sample, that enable the identification of hidden sub-layers in the case of paints and mural paintings. In this paper, we present the THz TDS2 system developed in the European Commission's 7th Framework Program project CHARISMA [grant agreement no. 228330]. Bespoke single processing algorithms; including a deconvolution algorithm can be deployed to increase the resolution and the global performance of the system. The potential and impact of this work is demonstrated through two case studies of mural paintings, where the capability to reveal the stratigraphy of the artworks is demonstrated.

  19. Forecast Master Program case studies: Final report

    Energy Technology Data Exchange (ETDEWEB)

    Engle, R.; Granger, C.; Ramanathan, R. (ed.)

    1987-04-01

    This report presents a number of case studies using the computer software package FORECAST MASTER (FM). The series studied and forecast are, aggregate monthly California Electricity Sales, system energy demand data from Ontario Hydro, peak demand data for the residential and commercial customers of Georgia Power Company, Massachusetts Electric commercial sales, Narragansett Electric commercial sales, average and peak demand using Georgia Power Company data. A variety of methods have been studied by each of the contributing authors; trend line fitting, exponential smoothing, Box-Jenkins univariate forecasting, vector autoregression, state space modeling, dynamic econometric models including time-varying parameters and general order serial correlation corrections. Thus both the data sets and the modeling/forecasting methodologies are varied. A number of conclusions emerge from these case studies: FM provides a powerful set of tools to aid a utility forecaster, a great deal of caution should be exercised in pre-processing the data; it can have unintended side effects, diagnostic tests are very useful in econometric models, the Akaike Information Criterion is a useful measure for selecting the best state space model, and state space and econometric approaches both need equal amounts of care in model analysis and presentation.

  20. Estudo das alterações ecocardiográficas nos primeiros seis meses após o transplante renal Study of echocardiographic alterations in the first six months after kidney transplantation

    Directory of Open Access Journals (Sweden)

    Francival Leite de Souza

    2012-06-01

    Full Text Available FUNDAMENTO: Alterações cardíacas são muito frequentes nos indivíduos portadores de doença renal crônica terminal e estão associadas com a morbimortalidade. OBJETIVOS: Avaliar as alterações evolutivas cardíacas após o transplante renal. MÉTODOS: Foram avaliados prospectivamente 40 pacientes com doença renal crônica terminal, imediatamente antes e com um mês, três meses e seis meses após o transplante renal, por meio de estudo ecocardiográfico com Doppler tecidual. Os parâmetros de massa ventricular, função sistólica e diastólica foram analisados. RESULTADOS: A média da idade foi 31,6 anos e 40% eram do sexo feminino. Observamos redução do diâmetro diastólico do VE (52,23 para 49,95 mm, p = 0,021 e do índice de massa do VE (131,48 para 113,039 g/m², p = 0,002 após o transplante renal. A razão E/e' média reduziu no terceiro e no sexto meses após o transplante renal em relação ao exame basal (8,13 e 7,85 vs 9,79, p BACKGROUND: Cardiac disorders are very common in individuals with chronic kidney disease and are associated with morbimortality. OBJECTIVE: To evaluate cardiac alterations after kidney transplantation. METHODS: We prospectively evaluated 40 patients with chronic kidney disease, immediately before and one month, three months and six months after kidney transplantation, using tissue Doppler echocardiographic study. The left ventricular mass, systolic and diastolic function parameters were analyzed. RESULTS: The mean age was 31.6 years and 40% of patients were female. We observed a reduction in left ventricular diastolic diameter (52.23 to 49.95 mm, p = 0.021 and LV mass index (131.48 to 113.039 g/m2, p = 0.002 after kidney transplantation. The mean E/e' decreased in the third and sixth months after kidney transplantation, when compared to basal values (8.13 and 7.85 vs. 9.79, p <0.05. The ejection fraction increased from the first month after kidney transplantation compared to basal assessment (69.72% vs

  1. Estudo piloto dos efeitos da terapia hormonal sobre o tecido mamário normal de mulheres após a menopausa A pilot study of the effects of hormone therapy on normal breast tissue of postmenopausal women

    Directory of Open Access Journals (Sweden)

    Simone Elias

    2006-11-01

    Full Text Available OBJETIVOS: avaliou-se o tecido mamário de mulheres antes e depois de seis meses de terapia estroprogestativa combinada contínua (0,625 mg de estrogênios conjugados eqüinos associados a 2,5 mg de acetato de medroxiprogesterona. MÉTODOS: todas as pacientes foram avaliadas antes de se instituir o tratamento e consideradas aptas para este. Foram obtidos fragmentos de tecido mamário por meio de biópsia percutânea com agulha grossa (acoplada a um propulsor automático - "core-biópsia". O material foi fixado e os cortes corados por hematoxilina-eosina. Avaliou-se a densidade epitelial e o volume nuclear do epitélio mamário antes e após a terapia hormonal. Esses parâmetros morfométricos foram analisados graficamente com auxílio do programa Imagelab 2000 ®, após captura da imagem microscópica pelo sistema Vidcap 32. Esse programa permite que sejam selecionadas as áreas de interesse, possibilitando o cálculo de área, volume ou a relação da área ocupada entre diferentes estruturas. RESULTADOS: depois do uso da terapia, o volume nuclear nas mulheres em que o tratamento foi instituído em período mais tardio após a menopausa mostrou um aumento de cerca de 33% (de 103,6 para 138,1 µm³. A densidade epitelial não se modificou de forma significativa: o valor médio antes da terapia hormonal foi de 0,08 e após de 0,10. CONCLUSÕES: a terapia estroprogestativa combinada contínua empregada por seis meses induziu à alteração no volume nuclear das células epiteliais das mamas, sugerindo aumento de sua atividade metabólica. Provavelmente, esse evento precede outros que confirmariam o estímulo da proliferação celular por esses hormônios.PURPOSE: to analyze breast tissue of postmenopausal women before and after six months of continuous combined estrogen-progestin replacement therapy (0.625 mg conjugated equine estrogens associated with 2.5 mg medroxyprogesterone acetate. METHODS: all patients were evaluated before treatment and

  2. Ectopic expression of Jatropha curcas APETALA1 (JcAP1 caused early flowering in Arabidopsis, but not in Jatropha

    Directory of Open Access Journals (Sweden)

    Mingyong Tang

    2016-04-01

    Full Text Available Jatropha curcas is a promising feedstock for biofuel production because Jatropha oil is highly suitable for the production of biodiesel and bio-jet fuels. However, Jatropha exhibits a low seed yield as a result of unreliable and poor flowering. APETALA1 (AP1 is a floral meristem and organ identity gene in higher plants. The flower meristem identity genes of Jatropha have not yet been identified or characterized. To better understand the genetic control of flowering in Jatropha, an AP1 homolog (JcAP1 was isolated from Jatropha. An amino acid sequence analysis of JcAP1 revealed a high similarity to the AP1 proteins of other perennial plants. JcAP1 was expressed in inflorescence buds, flower buds, sepals and petals. The highest expression level was observed during the early developmental stage of the flower buds. The overexpression of JcAP1 using the cauliflower mosaic virus (CaMV 35S promoter resulted in extremely early flowering and abnormal flowers in transgenic Arabidopsis plants. Several flowering genes downstream of AP1 were up-regulated in the JcAP1-overexpressing transgenic plant lines. Furthermore, JcAP1 overexpression rescued the phenotype caused by the Arabidopsis AP1 loss-of-function mutant ap1-11. Therefore, JcAP1 is an ortholog of AtAP1, which plays a similar role in the regulation of flowering in Arabidopsis. However, the overexpression of JcAP1 in Jatropha using the same promoter resulted in little variation in the flowering time and floral organs, indicating that JcAP1 may be insufficient to regulate flowering by itself in Jatropha. This study helps to elucidate the function of JcAP1 and contributes to the understanding of the molecular mechanisms of flower development in Jatropha.

  3. MMN、P300、ApEn在轻度认知功能障碍诊断中的价值探讨%A study of the value of MMN,ERP,and ApEn in diagnosis of mild cognitive impairment

    Institute of Scientific and Technical Information of China (English)

    郝良芳; 季晓林

    2013-01-01

    To analyze the changes of MMN,P300 and ApEn in patients with mild cognitive impairment (MCI) and healthy control subjects,and evaluate the diagnostic value of MMN,ERP and ApEn in diagnosis of MCI.Methods:According to the criteria of MCI made by Peterson,46 subjects with MCI and 48 normal controls (NC) were involved in the examination of neuropsychological scale,MMN,ERP and electroencephalogram.Changes of MMN,ERP and ApEn in all subjects were measured and analyzed.Results:①Compared with NC group,MCI patients showed prolonged MMN,N2,P3 peak latency was and the N2-P3 peak-to-peak latencies,there was apparent difference in neuropsy-chological measures(P<0.01).②MMN latency was correlated with the latencies of N2 and P3(P<0.01).③The latency of MMN,N2,P3 and the N2-P3 peak-to-peak latencies were negatively correlated with MMSE.There was apparent difference in neuropsychological measures(P<0.01).④Compared with NC group,paitents with MCI had lower EEG ApEn in terms of Fp1,C3,P3,P4,T3,T4,T5 in eye-closed state; As well in terms of Fp1,Fp2,P4,C3,C4,P3,P4,F7,F8,T3,T4,T5 in mental arithmetic with eyes closed.⑤ Patients with prolonged latency of MMN,N2,P3 accounted for 54,54,76 percent of patients with MCI respectively.At least one encephalic region with lower EEG ApEn accounted for 68.0 and 100 percent of patients who had prolonged MMN latency with MCI respectively in eye-closed and mental arithmetic state;accounting for 71 and 91 percent of patients with prolonged P3 latency respectively.Conclusion:② MMN,ERP and nonlinear dynamic analysis of EEG may be auxiliary diagnosis of MCI.②MMN,ERP and ApEn can be used to evaluate the cognitive functions of patients with MCI.The combination of MMN,ERP and ApEn can offer objective basis for the assessment of MCI.%目的:分析轻度认知功能障碍(MCI)患者和正常对照组失匹配负波(MMN)、事件相关电位(ERP)及脑电活动非线性指数近似熵(ApEn)的变化,评估MMN、P300、ApEn在MCI诊断中的

  4. Parameterized Synthesis Case Study: AMBA AHB

    Directory of Open Access Journals (Sweden)

    Roderick Bloem

    2014-07-01

    Full Text Available We revisit the AMBA AHB case study that has been used as a benchmark for several reactive synthesis tools. Synthesizing AMBA AHB implementations that can serve a large number of masters is still a difficult problem. We demonstrate how to use parameterized synthesis in token rings to obtain an implementation for a component that serves a single master, and can be arranged in a ring of arbitrarily many components. We describe new tricks - property decompositional synthesis, and direct encoding of simple GR(1 - that together with previously described optimizations allowed us to synthesize a component model with 14 states in about 1 hour.

  5. Case study: Bioremediation in the Aleutian Islands

    Energy Technology Data Exchange (ETDEWEB)

    Steward, K.J.; Laford, H.D. [URS Consultants, Inc., Seattle, WA (United States)

    1995-12-31

    This case study describes the design, construction, and operation of a bioremediation pile on Adak Island, which is located in the Aleutian Island chain. Approximately 1,900 m{sup 3} of petroleum-contaminated soil were placed in the bioremediation pile. The natural bioremediation process was enhanced by an oxygen and nutrient addition system to stimulate microbial activity. Despite the harsh weather on the island, after the first 6 months of operation, laboratory analyses of soil samples indicated a significant (80%) reduction in diesel concentrations.

  6. Russian Media Educators: Case Studies Portraits

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2013-01-01

    Full Text Available This article is devoted to case studies of the media education works of some well knowns Russian media educators. The analysis of media educational work of the famous Russian media educators leads us to the conclusion that media education in Russia is developing, building on the synthesis of the aesthetic, socio-cultural, and practical concepts, with a focus on the development of media competence of the audience, mainly school and youth. The enthusiasts of media education, even devoid of substantial public support for its innovative projects, achieve significant and meaningful results.

  7. Metrology in Pharmaceutical Industry - A Case Study

    Science.gov (United States)

    Yuvamoto, Priscila D.; Fermam, Ricardo K. S.; Nascimento, Elizabeth S.

    2016-07-01

    Metrology is recognized by improving production process, increasing the productivity, giving more reliability to the measurements and consequently, it impacts in the economy of a country. Pharmaceutical area developed GMP (Good Manufacture Practice) requeriments, with no introduction of metrological concepts. However, due to Nanomedicines, it is expected this approach and the consequent positive results. The aim of this work is to verify the level of metrology implementation in a Brazilian pharmaceutical industry, using a case study. The purpose is a better mutual comprehension by both areas, acting together and governmental support to robustness of Brazilian pharmaceutical area.

  8. Case studies in Bayesian microbial risk assessments

    Directory of Open Access Journals (Sweden)

    Turner Joanne

    2009-12-01

    Full Text Available Abstract Background The quantification of uncertainty and variability is a key component of quantitative risk analysis. Recent advances in Bayesian statistics make it ideal for integrating multiple sources of information, of different types and quality, and providing a realistic estimate of the combined uncertainty in the final risk estimates. Methods We present two case studies related to foodborne microbial risks. In the first, we combine models to describe the sequence of events resulting in illness from consumption of milk contaminated with VTEC O157. We used Monte Carlo simulation to propagate uncertainty in some of the inputs to computer models describing the farm and pasteurisation process. Resulting simulated contamination levels were then assigned to consumption events from a dietary survey. Finally we accounted for uncertainty in the dose-response relationship and uncertainty due to limited incidence data to derive uncertainty about yearly incidences of illness in young children. Options for altering the risk were considered by running the model with different hypothetical policy-driven exposure scenarios. In the second case study we illustrate an efficient Bayesian sensitivity analysis for identifying the most important parameters of a complex computer code that simulated VTEC O157 prevalence within a managed dairy herd. This was carried out in 2 stages, first to screen out the unimportant inputs, then to perform a more detailed analysis on the remaining inputs. The method works by building a Bayesian statistical approximation to the computer code using a number of known code input/output pairs (training runs. Results We estimated that the expected total number of children aged 1.5-4.5 who become ill due to VTEC O157 in milk is 8.6 per year, with 95% uncertainty interval (0,11.5. The most extreme policy we considered was banning on-farm pasteurisation of milk, which reduced the estimate to 6.4 with 95% interval (0,11. In the second

  9. Myonecrosis in Sickle Cell Anemia: Case Study

    Science.gov (United States)

    Turaga, Lalita Prabha; Boddu, Prajwal; Kipferl, Steve; Basu, Anupam; Yorath, Martin

    2017-01-01

    Patient: Male, 27 Final Diagnosis: Myonecrosis of sickle cell anaemia Symptoms: Pain • redness to feet • swelling foot Medication: — Clinical Procedure: MRI Specialty: Podiatry Objective: Rare disease Background: Myonecrosis is one of the more poorly studied, painful manifestations of sickle cell crisis. Medical literature is sparse detailing the manifestations and management of such symptoms. In myonecrosis, red cells containing sickle hemoglobin become rigid, resulting in reduced blood flow and myonecrosis. Case Report: We present a case study of a patient in sickle cell crisis with an episode of acute pain and swelling to the intrinsic muscles of the foot as a prominent feature of the crises. Although muscle biopsy is considered the gold standard for the diagnosis of myositis or myonecrosis, a low intensity signal on T1 and high intensity signal on T2 at the affected muscle belly can be as conclusive as imaging studies. In an actively sickling patient any invasive intervention should be avoided as it can result in ischemic necrosis of the tissues, due to interruption of capillary flow in end-arteries. Conclusions: Early recognition is critical in sickle cell disease management, allowing for prompt and aggressive fluid resuscitation which remains a cornerstone in the management of most sickle cell vaso-occlusive crises. In this instance, off loading the extremity and early fluid resuscitation resolved the pain and swelling and prevented myonecrosis. PMID:28133359

  10. Learning with Multimedia Cases: An Evaluation Study

    Science.gov (United States)

    Van Den Berg, Ellen; Jansen, Leanne; Blijleven, Peter

    2004-01-01

    This article is about the relation between case-based learning and transfer in teacher education. Through a design research approach a multimedia case has been developed. The topic of the case is "outdoor activities in science education." The core of the case is a 17 minute video that is supplemented by all kinds of background information. Results…

  11. [The SAPHO syndrome: a study of 16 cases].

    Science.gov (United States)

    Olivé, A; Pérez-Andrés, R; Rivas, A; Holgado, S; Casado, E; Gumá, M; Tena, X

    1999-01-23

    The SAPHO syndrome is characterized by synovitis, acne, palmo-plantar pustulosis, hyperostosis and osteitis. SAPHO syndrome has been occasionally described in Spain. We present our experience of 16 cases with the SAPHO syndrome diagnosed between 1984-1995. The predominant clinical symptoms were: anterior thoracic pain (14 cases), sacroiliac pain (7 cases) and peripheral arthritis (2 cases). Cutaneous involvement was characterized by palmo-plantar pustulosis (8 cases) acne (3 cases) and psoriasis (2 cases). The histocompatibility antigen B27 was negative in all cases. A computerized tomographic study revealed involvement of sterno-costo-clavicular and manubriosternal joints (14 cases) and sacroiliitis (8 cases).

  12. Delivering Online Examinations: A Case Study

    Directory of Open Access Journals (Sweden)

    John MESSING

    2004-07-01

    Full Text Available Delivering Online Examinations: A Case Study Jason HOWARTH John MESSING Irfan ALTAS Charles Sturt University Wagga Wagga-AUSTRALIA ABSTRACT This paper represents a brief case study of delivering online examinations to a worldwide audience. These examinations are delivered in partnership with a commercial online testing company as part of the Industry Master’s degree at Charles Sturt University (CSU. The Industry Master’s degree is an academic program for students currently employed in the IT industry. Using Internet Based Testing (IBT, these students are examined in test centres throughout the world. This offers many benefits. For example, students have the freedom of sitting exams at any time during a designated interval. Computer-based testing also provides instructors with valuable feedback through test statistics and student comments. In this paper, we document CSU’s use of the IBT system, including how tests are built and delivered, and how both human and statistical feedback is used to evaluate and enhance the testing process.

  13. Sacroiliac joint dysfunction: a case study.

    Science.gov (United States)

    Murray, William

    2011-01-01

    Pain is a widespread issue in the United States. Nine of 10 Americans regularly suffer from pain, and nearly every person will experience low back pain at one point in their lives. Undertreated or unrelieved pain costs more than $60 billion a year from decreased productivity, lost income, and medical expenses. The ability to diagnose and provide appropriate medical treatment is imperative. This case study examines a 23-year-old Active Duty woman who is preparing to be involuntarily released from military duty for an easily correctable medical condition. She has complained of chronic low back pain that radiates into her hip and down her leg since experiencing a work-related injury. She has been seen by numerous providers for the previous 11 months before being referred to the chronic pain clinic. Upon the first appointment to the chronic pain clinic, she has been diagnosed with sacroiliac joint dysfunction. This case study will demonstrate the importance of a quality lower back pain assessment.

  14. Case Study of the California Cement Industry

    Energy Technology Data Exchange (ETDEWEB)

    Coito, Fred; Powell, Frank; Worrell, Ernst; Price, Lynn; Friedmann, Rafael

    2005-05-01

    California is the largest cement producing state in theU.S., accounting for between 10 percent and 15 percent of U.S. cementproduction and cement industry employment. The cement industry inCalifornia consists of 31 sites that consume large amounts of energy,annually: 1,600 GWh of electricity, 22 million therms of natural gas, 2.3million tons of coal, 0.25 tons of coke, and smaller amounts of wastematerials, including tires. The case study summarized in this paperfocused on providing background information, an assessment ofenergy-efficiency opportunities and barriers, and program recommendationsthat can be used by program planners to better target products to thecement industry. The primary approach to this case study involvedwalk-through surveys of customer facilities and in depth interviews withcustomer decision makers and subsequent analysis of collected data. Inaddition, a basic review of the cement production process was developed,and summary cement industry energy and economic data were collected, andanalyzed. The analysis of secondary data provides background informationon the cement industry and identification of potential energy-efficiencyopportunities. The interviews provide some understanding of the customerperspective about implementation of energy-efficiencyprojects.

  15. Commercializing Emerging Renewable Energy: A Case Study

    Directory of Open Access Journals (Sweden)

    Matti Lehtovaara

    2012-12-01

    Full Text Available A broad scientific consensus exists that the global climate is changing. The Earth’s surface temperature could rise significantly over the next few decades, leading to us witnessing an entirely new and unknown planet. Improved energy efficiency, decreasing use of fossil fuels and wide diffusion of various renewable energy sources are among the focal measures to limit global warming to a sustainable level. The objective of this study is to analyse how renewable energy, such as wind power and bioenergy, could be efficiently commercialized. The evaluation is based on a case study and expert analyses exploiting lateral and parallel thinking methods, and group decision support systems tools. The results reveal that some of the generated ideas are ready for implementation to commercialize renewable energy, whereas others still require technical and commercial development and improvements before maturity.

  16. Social Architecture: An Emergency Management Case Study

    Directory of Open Access Journals (Sweden)

    Asif Qumer Gill

    2015-03-01

    Full Text Available Emergency management agencies are progressively using social media for the sourcing and distribution of disaster information. Emergency management agencies are often unsure as to how to best identify and assess social media concerns (e.g. information security, trust which must be addressed to develop a social media-enabled disaster information management environment. This paper adopts the Social Architecture Viewpoint Assessment (SAVA framework for identifying and assessing social media concerns from four different viewpoints: IT, Value, Resource and Management. This paper demonstrates the use of the SAVA framework in the context of an in-depth empirical case study of an Australian emergency management agency. The results of this study indicate that the SAVA framework is useful for emergency information management managers in identifying and assessing social media concerns.

  17. Climate change: a case study over India

    Energy Technology Data Exchange (ETDEWEB)

    Sahai, A.K. [Indian Institute of Tropical Meteorology, Pune (India)

    1998-12-31

    A brief account of various causes of climate change in recent decades and climate change trends in the Indian region is presented. Local temperature is one of the major climatic elements to record the changes in the atmospheric environment caused by industrialization and urbanization. Literature data show that there is either a cooling tendency or cessation of warming after the late 1950s at most of the Indian industrial cities. A case study of Nagpur, a centrally located city in India, is done to understand the possible causes of cooling. Nagpur is the only city in India for which a long-term record of temperature, for urban (Mayo Hospital) and relatively suburban (Sonegaon Airport) area, is available. The study of the diurnal asymmetry in maximum and minimum temperatures indicates that the role of suspended particulate matter dominates over that of increasing greenhouse gases.

  18. Nightmares and psychotic decompensation: a case study.

    Science.gov (United States)

    Levin, R; Daly, R S

    1998-01-01

    There have been numerous reports in the literature on the descriptive similarities between a severe nightmare and an acute psychotic episode. Nightmares may be a prelude to psychotic decompensation, and it has been suggested that frequent lifelong nightmares may even be diagnostic of an underlying vulnerability to psychosis. In this report, we present a case study of a 40-year old female experiencing chronic paranoid schizophrenia, whose two witnessed psychotic relapses in the hospital were immediately preceded by intense and vivid nightmare attacks. Significantly, the content of these nocturnal dreams was thematically consistent with her waking hallucinations, suggesting a direct continuity between these experiences. We propose that further systematic study of the dreams and nightmares of individuals diagnosed with schizophrenia may be particularly useful in understanding their phenomenological experience.

  19. Scheduling job shop - A case study

    Science.gov (United States)

    Abas, M.; Abbas, A.; Khan, W. A.

    2016-08-01

    The scheduling in job shop is important for efficient utilization of machines in the manufacturing industry. There are number of algorithms available for scheduling of jobs which depend on machines tools, indirect consumables and jobs which are to be processed. In this paper a case study is presented for scheduling of jobs when parts are treated on available machines. Through time and motion study setup time and operation time are measured as total processing time for variety of products having different manufacturing processes. Based on due dates different level of priority are assigned to the jobs and the jobs are scheduled on the basis of priority. In view of the measured processing time, the times for processing of some new jobs are estimated and for efficient utilization of the machines available an algorithm is proposed and validated.

  20. HPV16 E6 and E6AP differentially cooperate to stimulate or augment Wnt signaling

    Energy Technology Data Exchange (ETDEWEB)

    Sominsky, Sophia, E-mail: sophia.tab@gmail.com [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Kuslansky, Yael, E-mail: ykuslansky@gmail.com [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Shapiro, Beny, E-mail: benyshap@gmail.com [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Jackman, Anna, E-mail: jackman@post.tau.ac.il [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Haupt, Ygal, E-mail: ygal.haupt@petermac.org [Research Division, The Peter MacCallum Cancer Centre, East Melbourne (Australia); Rosin-Arbesfeld, Rina, E-mail: arina@post.tau.ac.il [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel); Sherman, Levana, E-mail: lsherman@post.tau.ac.il [Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 (Israel)

    2014-11-15

    The present study investigated the roles of E6 and E6AP in the Wnt pathway. We showed that E6 levels are markedly reduced in cells in which Wnt signaling is activated. Coexpression of wild-type or mutant E6AP (C820A) in Wnt-activated cells stabilized E6 and enhanced Wnt/β-catenin/TCF transcription. Expression of E6AP alone in nonstimulated cells elevated β-catenin level, promoted its nuclear accumulation, and activated β-catenin/TCF transcription. A knockdown of E6AP lowered β-catenin levels. Coexpression with E6 intensified the activities of E6AP. Further experiments proved that E6AP/E6 stabilize β-catenin by protecting it from proteasomal degradation. This function was dependent on the catalytic activity of E6AP, the kinase activity of GSK3β and the susceptibility of β-catenin to GSK3β phosphorylation. Thus, this study identified E6AP as a novel regulator of the Wnt signaling pathway, capable of cooperating with E6 in stimulating or augmenting Wnt/β-catenin signaling, thereby possibly contributing to HPV carcinogenesis. - Highlights: • The roles of E6 and E6AP in the Wnt pathway were investigated. • E6AP stabilizes E6 and enhances E6 activity in augmentation of Wnt signaling. • E6AP cooperates with E6 to stabilize β-catenin and stimulate Wnt/β-catenin signaling. • E6AP and E6 act through different mechanisms to augment or stimulate Wnt signaling.

  1. A Weighted K-AP Query Method for RSSI based Indoor Positioning

    DEFF Research Database (Denmark)

    Huo, Huan; Liu, Xiufeng; Li, Jifeng

    2016-01-01

    The paper studies the establishment of offline fingerprint library based on RSSI (Received Signal Strength Indication), and proposes WF-SKL algorithm by introducing the correlation between RSSIs. The correlations can be transformed as AP fingerprint sequence to build the offline fingerprint library....... To eliminate the positioning error caused by instable RSSI value, WF-SKL can filter the noise AP via online AP selection, meanwhile it also reduces the computation load. WF-SKL utilizes LCS algorithm to find out the measurement between the nearest neighbors, and it proposes K-AP (P,Q) nearest neighbor queries...

  2. Penetration dynamics of AP8 in thin ceramic tiles

    NARCIS (Netherlands)

    Abadjieva, E.; Khoe, Y.S.

    2013-01-01

    The interaction of thin ceramic tiles with AP8 (WC core, 7,62 mm) at 1000 m/s velocity has been studied experimentally and numerically. “Thin” ceramic tiles refers here to ratio of the tile thickness (t) to the projectile diameter, (d), t/d@ 1, as they are both in the same order. The method applied

  3. STAKEHOLDERS AND APART HOTELS: MULTIPLE CASE STUDY

    Directory of Open Access Journals (Sweden)

    Patrícia Freire Ferreira Oliveira

    2012-09-01

    Full Text Available Means of accommodation involve a wide range of social actors and agents, as well as different business models. Management strategies in this sector have been increasingly important for long-term sustainability and competitiveness of business organizations. This study aims to analyze the interactions between apart-hotels and their stakeholders to foster an improvement of services provided, aligning the interface of strategic management from the point of view of managers and their key stakeholders. It is an exploratory study, with qualitative chacter, along with multiple case studies of the following establishments: Travel Inn, Hotels Slaviero and Etoile george v. Brazilian enterprises, which manage lodging facilities with apart-hotel concepts, combining features that enable comparative analysis of the study. For conceptual understanding, this study was based on literature about stakeholders, taking the work of Freeman (1984 and Freeman et al (2010 as main references. The research was conducted through semi-structured interviews with managers of lodging facilities and their key stakeholders and through direct observation and documentation. We found that not all groups of influence are considered in the planning of service flats. However, the organizations surveyed indicated that the market has realized the importance of the groups that exert influence and are influenced by their goals, and are therefore increasingly alert for integration of such groups in their strategic planning.

  4. Distúrbios evacuatórios em primigestas após parto normal: estudo clínico Evacuatory disorders in primigravidae after vaginal delivery: clinical study

    Directory of Open Access Journals (Sweden)

    Maria Auxiliadora Prolungatti Cesar

    2011-06-01

    Full Text Available Introdução: Os distúrbios evacuatórios são descritos na literatura relacionados ao parto normal e episiotomia. Objetivo: Estudar a incidência de distúrbios evacuatórios em primíparas submetidas à episiotomia, durante o parto normal. Métodos: Estudo prospectivo em 32 pacientes primíparas, submetidas à episotomia durante parto vaginal. Para realização do estudo as pacientes reSponderam os questionários com o score de constipação de Agachan e score de incontinência de Jorge e Wexner, em relação ao período pré-gestacional e 90 dias após o parto. Resultados: Não foram encontradas diferenças estatisticamente significantes quando comparados os resultados dos questionários aplicados, em relação ao período pré-gestacional e 90 dias pós-parto. Conclusões: Não observamos alterações da constipação e continência fecal em primigestas após parto normal com episiotomia.Introduction: Evacuatories disturbances are described in the literature related to vaginal delivery and episiotomy. Objective: To study the incidence of evacuatories disturbances in primiparous undergoing episiotomy during vaginal delivery. Methods: Prospective study in 32 primiparous patients submitted to episotomy during vaginal delivery. For the study the patients answered in relation to the period before pregnancy and 90 days postpartum questionnaires with the score of Agachan constipation and incontinence score of Jorge and Wexner. Results: No statistically significant differences were found when comparing the results from the questionnaires in relation to the period before pregnancy and 90 days postpartum. Conclusions: Episiotomy in vaginal delivery in primiparous women with no prior history of intestinal symptoms, caused no disorders of anal continence postpartum in the pacients of this study.

  5. Anestesia subdural após punção peridural: relato de dois casos Anestesia subdural después punción peridural: relato de dos casos Subdural anesthesia after epidural puncture: two case reports

    Directory of Open Access Journals (Sweden)

    Carlos Escobar Vásquez

    2003-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Anestesias condutivas peridurais são realizadas amplamente no nosso meio. A anestesia subdural acidental após punção peridural é uma complicação rara. O objetivo deste relato é descrever dois casos de injeção subdural que coincidentemente ocorreram de forma consecutiva realizadas pelo mesmo anestesiologista. RELATO DOS CASOS: Caso 1: Paciente do sexo masculino, 41 anos, estado físico ASA I, a realizar procedimento cirúrgico de retirada de cálculo renal. Optou-se por anestesia peridural. Após 30 minutos do início da anestesia, o paciente mantinha-se comunicativo mas sonolento com SpO2 de 100%, quando lentamente começou a apresentar diminuição da SpO2 chegando a 80%. Apresentava-se inconsciente com apnéia e anisocoria. A partir deste momento foi levantada hipótese diagnóstica de anestesia subdural acidental. O paciente foi então intubado e mantido em ventilação controlada mecânica. Terminada a cirurgia, foi encaminhado para a sala de recuperação, recebendo alta após 6 horas, sem nenhuma alteração clínico-neurológica. Caso 2: Paciente do sexo feminino, 82 anos, estado físico ASA II, programado para procedimento cirúrgico de fixação de fratura transtrocanteriana. Optou-se por anestesia peridural contínua. Assim como no caso anterior, após 30 minutos, a paciente começou a apresentar diminuição da SpO2 para 90%. Mostrava-se inconsciente e com anisocoria; entretanto, sem apnéia. Optou-se por manter a paciente sob vigilância constante, não sendo necessária intubação. A hipótese diagnóstica aventada também neste caso foi de anestesia subdural acidental. Terminada a cirurgia, a paciente foi encaminhada à sala de recuperação pós-anestésica, tendo alta após 4 horas, sem nenhuma alteração clínico-neurológica. CONCLUSÕES: Anestesia subdural acidental é uma complicação extremamente rara. A hipótese diagnóstica de anestesia subdural acidental, nestes casos, limitou

  6. Adalimumab-associated antiphospholipid syndrome: a case report and review of the literature.

    Science.gov (United States)

    Hemmati, Iman; Kur, Jason

    2013-07-01

    This study aims for the presentation of the first reported case of adalimumab-associated antiphospholipid syndrome (APS) and review of the literature on adalimumab-induced vasculitis and APS. A case of APS associated with adalimumab use in a 67-year-old woman is reported. The English medical literature was reviewed for antitumor necrosis factor (TNF) agents and their association with APS and vasculitis. Adalimumab is a fully humanized monoclonal antibody targeted against TNF alpha that is widely used in the treatment of rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis, and Crohn's disease. Literature review reveals several cases of anti-TNF-induced vasculitis including cases associated with adalimumab. We report the first case of adalimumab-induced APS in a 67-year-old woman who developed APS and vasculitis associated with de novo positive anti-cardiolipin (aCL) antibody following the third dose of adalimumab therapy for the treatment of spondyloarthropathy. This is the first case demonstrating that a short course of adalimumab therapy may induce immunoglobulin M aCL autoantibodies leading to APS. With the growing use of anti-TNF medications in immune-mediated and inflammatory diseases, adalimumab and other anti-TNF medications should be considered as a possible explanation for APS.

  7. Building Energy Information Systems: User Case Studies

    Energy Technology Data Exchange (ETDEWEB)

    Granderson, Jessica; Piette, Mary Ann; Ghatikar, Girish

    2010-03-22

    Measured energy performance data are essential to national efforts to improve building efficiency, as evidenced in recent benchmarking mandates, and in a growing body of work that indicates the value of permanent monitoring and energy information feedback. This paper presents case studies of energy information systems (EIS) at four enterprises and university campuses, focusing on the attained energy savings, and successes and challenges in technology use and integration. EIS are broadly defined as performance monitoring software, data acquisition hardware, and communication systems to store, analyze and display building energy information. Case investigations showed that the most common energy savings and instances of waste concerned scheduling errors, measurement and verification, and inefficient operations. Data quality is critical to effective EIS use, and is most challenging at the subsystem or component level, and with non-electric energy sources. Sophisticated prediction algorithms may not be well understood but can be applied quite effectively, and sites with custom benchmark models or metrics are more likely to perform analyses external to the EIS. Finally, resources and staffing were identified as a universal challenge, indicating a need to identify additional models of EIS use that extend beyond exclusive in-house use, to analysis services.

  8. Case-Studie af Fredericia Battle 1849

    DEFF Research Database (Denmark)

    Konzack, Lars

    2015-01-01

    En gennemgang af hvordan oplevelsesøkomien fungerer diskursivt - med Fredericia Battle 1849 som case.......En gennemgang af hvordan oplevelsesøkomien fungerer diskursivt - med Fredericia Battle 1849 som case....

  9. Study on Case-Based Fixture Design

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Fixture is an important manufacturing activity. A fixture design system based on case-based reasoning (CBR) is proposed in this paper. A new method of case representation on the basis of fixture function is presented, where the case representation is constituted of workpiece knowledge, processing feature knowledge, and fixture feature knowledge. Running the prototype system shows that the knowledge representation method, using cases, is a better way to transform and explain the design knowledge.

  10. Logistics opportunity costs: A mining case study

    Directory of Open Access Journals (Sweden)

    Leani van Jaarsveld

    2013-05-01

    Full Text Available This study highlighted the importance of determining the impact that an ineffective mode of transport has on a firm’s transportation model and costs. The main focus of this study was to determine the logistics opportunity costs of using road transport within a mining firm. A case study approach was followed, as the investigation aimed to analyse a complex problem experienced by one company and present it in an easily understandable format. From the results of this study, it was apparent that the logistics opportunity costs associated with the mode of transport was substantial. This highlighted the need for firms to revise their choice of transport mode on a regular basis, as it has a major impact not only on their transportation costs, but also on their inventory holding and carbon emissions. The results also have implications for South Africa’s only freight railway, Transnet Freight Rail, which should not only focus on expanding its existing capacity, but also on improving its customer service delivery whilst containing tariff increases.

  11. Pentoxifylline Treatment in Acute Pancreatitis (AP)

    Science.gov (United States)

    2016-09-14

    Acute Pancreatitis (AP); Gallstone Pancreatitis; Alcoholic Pancreatitis; Post-ERCP/Post-procedural Pancreatitis; Trauma Acute Pancreatitis; Hypertriglyceridemia Acute Pancreatitis; Idiopathic (Unknown) Acute Pancreatitis; Medication Induced Acute Pancreatitis; Cancer Acute Pancreatitis; Miscellaneous (i.e. Acute on Chronic Pancreatitis)

  12. 储氢合金/AP/HTPB推进剂燃烧性能研究%Investigation on Combustion Properties of Hydrogen Storage Alloy/AP/HTPB Propellant

    Institute of Scientific and Technical Information of China (English)

    窦燕蒙; 罗运军; 李国平; 葛震

    2013-01-01

    AI/AP/HTPB propellant and hydrogen storage alloy/AP/HTPB propellant were prepared and their properties were characterized by DSC,PDSC,explosion heat and burning rate test. DSC and PDSC test results show that hydrogen storage alloy has catalysis on condensed phase reactions of AP/HTPB propellant in which main decomposition temperature is decreased by 21.67℃,and 15. 67 ℃ at 0. 1MPa and 5MPa,respectively while condensed phase reaction heat is increased by 105. 97% and 21. 87% separately. Explosion heat test results show that hydrogen storage alloy has catalysis on gas phase reactions of AP/HTPB propellant in which gas phase reaction heat is increased by 4. 74% . Burning rate test results show that hydrogen storage alloy can increase burning rate of AP/HTPB propellant. Further studies indicate that possible correlation exist between burning rate and explosion heat of Al/AP/HTPB propellant and hydrogen storage alloy/AP/HTPB propellant. The burning rate-explosion heat formula is summed up.%制备了Al/AP/HTPB推进剂和储氢合金/AP/HTPB推进剂,并对它们进行了DSC,PDSC,爆热和燃速测试.DSC和PDSC测试结果表明,储氢合金对AP/HTPB推进剂的凝聚相反应有催化作用,在0.1MPa和5MPa下,使其凝聚相主分解温度分别降低21.67℃和15.67℃,凝聚相反应热分别提高105.97%和21.87%;爆热测试结果表明,储氢合金对AP/HTPB推进剂的气相反应有催化作用,使气相反应热提高4.74%;燃速结果表明,储氢合金可以提高AP/HTPB推进剂的燃速.进一步研究表明,A1/AP/HTPB推进剂和储氢合金/AP/HTPB推进剂的燃速与爆热存在一定的相关性.总结出了燃速-爆热关系式.

  13. Understanding Support - lessons from a case study

    Directory of Open Access Journals (Sweden)

    Chris Sauer

    1993-11-01

    Full Text Available Support from top management and others is agreed to be an important factor in information systems success and failure, but little is written about how it has its effect and how it might be managed to a project's advantage. A recently developed conceptual framework is described. It covers the nature and forms of support, the way support affects project outcomes, the bases on which support is provided, and the strategies by which support may be managed. The framework is used to analyse a case study in several stages. At the end of the analysis of each stage, the framework's utility is assessed in terms of its explanatory value and the practical advice it suggests. Areas for further research are identified.

  14. Automated cardiopulmonary resuscitation: a case study.

    Science.gov (United States)

    Spiro, Jon; Theodosiou, Maria; Doshi, Sagar

    2014-02-01

    Rates of survival after cardiac arrest are low and correlate with the quality of cardiopulmonary resuscitation (CPR). Devices that deliver automated CPR (A-CPR) can provide sustained and effective chest compressions, which are especially useful during patient transfer and while simultaneous invasive procedures are being performed. The use of such devices can also release members of resuscitation teams for other work. This article presents a case study involving a man with acute myocardial infarction complicated by cardiogenic shock and pulmonary oedema. It describes how ED nursing and medical teams worked together to deliver A-CPR, discusses the use of A-CPR devices in a tertiary cardiac centre, and highlights the advantages of using such devices.

  15. Vitamin K deficiency bleeding: a case study.

    Science.gov (United States)

    Woods, Christopher W; Woods, Amanda G; Cederholm, Carmen K

    2013-12-01

    Vitamin K deficiency bleeding (VKDB), formerly known as hemorrhagic disease of the newborn (HDN), is a bleeding disorder in neonates that is caused by inadequate serum levels of vitamin K. Vitamin K is a nutrient essential for adequate function of the coagulation cascade. Certain internal and external factors place newborn infants at higher risk for VKDB. Therefore, vitamin K prophylaxis has become the standard of care for newborns. Although the American Academy of Pediatrics recommends the administration of vitamin K to newborns, some parents are choosing to withhold vitamin K administration at birth. This case study describes an infant who developed VKDB in the absence of vitamin K prophylaxis. Although parents ultimately have the right to choose whether or not to administer vitamin K, as healthcare professionals, it is important to provide education regarding the potential complications of withholding vitamin K and the signs of VKDB if vitamin K prophylaxis at birth is withheld.

  16. The virtual information: a case study

    Directory of Open Access Journals (Sweden)

    Ginevra Gravili

    2012-09-01

    Full Text Available In todays economics, the fact that information is a major factor of production and of increasing importance as a source of competitive advantage is a generally accepted truism. The trend towards global markets has strongly impacted the competitive situation of many enterprises. Never has the economic environment been subject to so many drastic and rapid changes. This put new weight factors on the requirements for design of business process. This paper explores the case of an Italian legal office that has studied more and more innovative solutions both to satisfy the demands of the clienteles and to oppose the action of the new competitors. Comparing classic models and the theories of Porter with the characteristics and needs of new economy, it shows as the ability to possess, to easily have access, to creatively use of information constitutes one of the more strategic sources of the competitive advantage.

  17. Late ulnar paralysis. Study of seventeen cases.

    Science.gov (United States)

    Mansat, M; Bonnevialle, P; Fine, X; Guiraud, B; Testut, M F

    1983-01-01

    Seventeen cases of late ulnar paralysis treated by neurolysis-transposition are reported. The clinical characteristics of these paralysis are emphasized. A very prolonged symptom free interval, a rapid onset and a severe involvement. The ulnar transposition was most often done subcutaneously. Cubitus valgus and definite nerve compression proximal to the arcade of the flexor carpi ulnaris muscle are almost always present. The results as regards the neuropathy are notable: no patient is completely cured and only half are improved. An anatomical study of the nerve path shows the essential role, in the compression of the nerve, of the muscular arcade of the flexor carpi ulnaris muscle which acts in a way similar to the bridge of a violin. Hence, opening it longitudinally is the principal procedure of the neurolysis. This should be routine before the first signs of neuropathy occur in an elbow whose axis is out of alignment as a sequela of a childhood injury.

  18. Heterologous expression in Tritrichomonas foetus of functional Trichomonas vaginalis AP65 adhesin

    Directory of Open Access Journals (Sweden)

    Alderete JF

    2005-03-01

    Full Text Available Abstract Background Trichomonosis, caused by Trichomonas vaginalis, is the number one, nonviral sexually transmitted infection that has adverse consequences for the health of women and children. The interaction of T. vaginalis with vaginal epithelial cells (VECs, a step preparatory to infection, is mediated in part by the prominent surface protein AP65. The bovine trichomonad, Tritrichomonas foetus, adheres poorly to human VECs. Thus, we established a transfection system for heterologous expression of the T. vaginalis AP65 in T. foetus, as an alternative approach to confirm adhesin function for this virulence factor. Results In this study, we show stable transfection and expression of the T. vaginalis ap65 gene in T. foetus from an episomal pBS-ap65-neo plasmid. Expression of the gene and protein was confirmed by RT-PCR and immunoblots, respectively. AP65 in transformed T. foetus bound to host cells. Specific mAbs revealed episomally-expressed AP65 targeted to the parasite surface and hydrogenosome organelles. Importantly, surface-expression of AP65 in T. foetus paralleled increased levels of adherence of transfected bovine trichomonads to human VECs. Conclusion The T. vaginalis AP65 adhesin was stably expressed in T. foetus, and the data obtained using this heterologous system strongly supports the role of AP65 as a prominent adhesin for T. vaginalis. In addition, the heterologous expression in T. foetus of a T. vaginalis gene offers an important, new approach for confirming and characterizing virulence factors.

  19. A case study in pathway knowledgebase verification

    Directory of Open Access Journals (Sweden)

    Shah Nigam H

    2006-04-01

    Full Text Available Abstract Background Biological databases and pathway knowledgebases are proliferating rapidly. We are developing software tools for computer-aided hypothesis design and evaluation, and we would like our tools to take advantage of the information stored in these repositories. But before we can reliably use a pathway knowledgebase as a data source, we need to proofread it to ensure that it can fully support computer-aided information integration and inference. Results We design a series of logical tests to detect potential problems we might encounter using a particular knowledgebase, the Reactome database, with a particular computer-aided hypothesis evaluation tool, HyBrow. We develop an explicit formal language from the language implicit in the Reactome data format and specify a logic to evaluate models expressed using this language. We use the formalism of finite model theory in this work. We then use this logic to formulate tests for desirable properties (such as completeness, consistency, and well-formedness for pathways stored in Reactome. We apply these tests to the publicly available Reactome releases (releases 10 through 14 and compare the results, which highlight Reactome's steady improvement in terms of decreasing inconsistencies. We also investigate and discuss Reactome's potential for supporting computer-aided inference tools. Conclusion The case study described in this work demonstrates that it is possible to use our model theory based approach to identify problems one might encounter using a knowledgebase to support hypothesis evaluation tools. The methodology we use is general and is in no way restricted to the specific knowledgebase employed in this case study. Future application of this methodology will enable us to compare pathway resources with respect to the generic properties such resources will need to possess if they are to support automated reasoning.

  20. Peculiar Traits of Coarse AP (Briefing Charts)

    Science.gov (United States)

    2014-12-01

    Self Combustion 3 Thom L. Boggs Parallel ridges and valley surfaces seen at 1000 to 1500 psi Isolated AP vertical needle pockets at 1500 and 1800 psi...Negative exponents, bouncing flamlets between 2000 to 4000 psi Extremely irregular AP surface regression Hightower and Price 16 Air Force Research...supported by vertical gas jetlets from active centers? Did Boggs burn a few samples at 1000 to 2000 psi with orthorhombic main axis normal to

  1. EVALUATION OF AP-FARM SIMULANT COMPOSITION FOR ROTARY MICROFILTER TESTING

    Energy Technology Data Exchange (ETDEWEB)

    HUBER HJ

    2011-09-19

    This document identifies the feed composition of a Hanford AP tank farm simulant for rotary microfiltration testing. The composition is based on an Hanford Tank Waste Operations Simulator (HTWOS) model run in combination with Tank Waste Information Network (TWINS) data and mineralogical studies of actual waste solids. The feed simulant is intended to be used in test runs at SRNL. The simulant will be prepared in two parts: (1) A supernate, composed of water-soluble salts and (2) The undissolved (actually, undissolvable) solids. Test slurries with distinct solids concentrations (e.g., 0.5, 5 and 10 wt%) are then prepared as needed. The base for the composition of supernate and solids is the modeled feed sequence for a deployment scenario of the Supplemental Pretreatment units within AP-farm. These units comprise a filtration part, the RMF, and a Cesium-removal part, a Small Column Ion Exchange. The primary use of this simulant is for filtration testing - however, in case that it is also used for ion-exchange tests, the amount of Cs-137 that would need to be added is available in Table 1 and Attachment 3. A modified model run (MMR-049) of the Hanford Tank Waste Operations Simulator (HTWOS) system plan 6 case 3 was performed to identify the feed sequence. Case 3 assumed supplemental treatment besides the low activity waste (LAW) melter with supplemental pretreatment supporting the pretreatment facility. The MMR did not cap the duration of supplemental pretreatment to 15 months, but rather used it throughout the entire treatment mission as an add-on option to the pretreatment facility at the Waste Treatment and Immobilization Plant (WTP). Tank 241-AP-105 (AP-105) was chosen as the feed tank to the filtration unit. Other parameters included a fixed minimum of 0.5 wt% solids in the feed and a maximum Na-concentration of 5M in the supernate. The solids rejection from the filtration unit was set to 99.99% and the maximum allowed amount of solids within tank AP-105 was set

  2. Tank 241-AP-106, Grab samples, 6AP-98-1, 6AP-98-2 and 6AP-98-3 Analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    FULLER, R.K.

    1999-02-23

    This document is the final report for tank 241-AP-106 grab samples. Three grab samples 6AP-98-1, 6AP-98-2 and 6AP-98-3 were taken from riser 1 of tank 241-AP-106 on May 28, 1998 and received by the 222-S Laboratory on May 28, 1998. Analyses were performed in accordance with the ''Compatability Grab Sampling and Analysis Plan'' (TSAP) (Sasaki, 1998) and the ''Data Quality Objectives for Tank Farms Waste Compatability Program (DQO). The analytical results are presented in the data summary report. No notification limits were exceeded. The request for sample analysis received for AP-106 indicated that the samples were polychlorinated biphenyl (PCB) suspects. The results of this analysis indicated that no PCBs were present at the Toxic Substance Control Act (TSCA) regulated limit of 50 ppm. The results and raw data for the PCB analysis are included in this document.

  3. Duplication of AP1 within the Spinacia oleracea L. AP1/FUL clade is followed by rapid amino acid and regulatory evolution.

    Science.gov (United States)

    Sather, D Noah; Golenberg, Edward M

    2009-02-01

    The AP1/FUL clade of MADS box genes have undergone multiple duplication events among angiosperm species. While initially identified as having floral meristem identity and floral organ identity function in Arabidopsis, the role of AP1 homologs does not appear to be universally conserved even among eudicots. In comparison, the role of FRUITFULL has not been extensively explored in non-model species. We report on the isolation of three AP1/FUL genes from cultivated spinach, Spinacia oleracea L. Two genes, designated SpAPETALA1-1 (SpAP1-1) and SpAPETALA1-2 (SpAP1-2), cluster as paralogous genes within the Caryophyllales AP1 clade. They are highly differentiated in the 3', carboxyl-end encoding region of the gene following the third amphipathic alpha-helix region, while still retaining some elements of a signature AP1 carboxyl motifs. In situ hybridization studies also demonstrate that the two paralogs have evolved different temporal and spatial expression patterns, and that neither gene is expressed in the developing sepal whorl, suggesting that the AP1 floral organ identity function is not conserved in spinach. The spinach FRUITFULL homolog, SpFRUITFULL (SpFUL), has retained the conserved motif and groups with Caryophyllales FRUITFULL homologs. SpFUL is expressed in leaf as well as in floral tissue, and shows strong expression late in flower development, particularly in the tapetal layer in males, and in the endothecium layer and stigma, in the females. The combined evidence of high rates of non-synonymous substitutions and differential expression patterns supports a scenario in which the AP1 homologs in the spinach AP1/FUL gene family have experienced rapid evolution following duplication.

  4. Hubble Case Studies of Transiting Giant Exoplanets

    Science.gov (United States)

    Wilkins, Ashlee N.; Deming, Drake; Barker, Adrian; Benneke, Björn; Delrez, Laetitia; Gillon, Michaël; Hamilton, Douglas P.; Jehin, Emmanuel; Knutson, Heather; Lewis, Nikole K.; Madhusudhan, Nikku; Mandell, Avi; McCullough, Peter R.; Wakeford, Hannah R.

    2017-01-01

    The study of planets around other stars has entered a science-rich era of characterization, in which detailed information about individual planets can be inferred from observations beyond mere detection, which only yields bulk properties like mass or radius. Characterization probes more revealing quantities such as chemical abundances, albedo, and temperature/pressure profiles, which allow us to address larger questions of planet formation mechanisms, planetary evolution, and, eventually, habitability and presence of biosignature gases. The primary method for characterization of close-in planets is transit spectroscopy. This dissertation talk will focus on transiting exoplanet case studies with the Hubble Space Telescope’ Wide-Field Camera-3 (WFC-3) as a tool of exoplanet characterization in a near-infrared band dominated by strong water features. I will first present a characterization the WFC-3 systematic effects that must be mitigated to extract the incredibly small (tens to 200 parts per million) signals, and then a study of four transiting giant planets (HATS-7b, HAT-p-3b, HD 149026b, and WASP-18b) in transmission, and two (WASP-18b and CoRoT-2b) in eclipse. Finally, I will discuss the role of transit timing monitoring of WASP-18b with HST and other observatories as another clue to its evolution as a close-in, massive planet. The five planets range from Neptune-class to Super-Jupiter-class in size/mass. Though these planets may be relatively rare, their observability represents a unique opportunity to probe planet formation and evolution, as well as atmospheric structures in a high-irradiation environment. These observations also yield insights into aerosols (i.e. clouds/hazes) in the atmosphere; clouds and/or hazes should significantly impact atmospheric chemistry and observational signatures, and we as a community must get a better handle on the phenomenon of aerosols in advance of the next generation of space observatories, including JWST and WFIRST

  5. Estudo da estabilidade da coluna lombar após facetectomia Estudio de la estabilidad de la columna lumbar después de la facetectomía The study of lumbar spine's stability after facetectomy

    Directory of Open Access Journals (Sweden)

    José Roberto Rossanez

    2009-09-01

    Full Text Available OBJETIVO: determinar a presença, ou não, de instabilidade lombar após a realização de facetectomia total unilateral para a descompressão radicular. MÉTODOS: os autores realizaram uma análise retrospectiva por avaliação clínica e radiográfica de 29 pacientes operadores, por discopatia, durante o período de janeiro de 1985 até janeiro de 1995. Os pacientes apresentavam queixa de dor ciática aguda, sem dor lombar prévia, e foram submetidos à facetectomia total unilateral para a descompressão radicular. Os casos operados por esta técnica necessitaram de manipulações excessivas com riscos de lesão da raiz nervosa. RESULTADOS: após um seguimento que variou de 9 a 17 anos, os resultados foram excelentes em 17 pacientes, bom em 9, regular em 3. CONCLUSÃO: nessa série de casos, a facetectomia total unilateral não foi fator determinante de instabilidade lombar.OBJETIVO: determinar la presencia o no de la inestabilidad lumbar después de la realización de facetectomía total unilateral para la descompresión radicular. MÉTODOS: los autores realizaron un análisis retrospectivo por evaluación clínica y radiográfica de 29 pacientes operados por discopatía, durante el periodo de Enero de 1985 hasta Enero de 1995. Los pacientes presentaban queja de dolor ciática aguda, sin dolor lumbar previa y fueron sometidos a la facetectomía total unilateral para la descompresión radicular. Los casos operados por esta técnica necesitaron de manipulaciones excesivas con riesgo de lesión de la raíz nerviosa. RESULTADOS: después de un seguimiento que varió de 9 a 17 años, los resultados fueron excelentes en 17 pacientes, bueno en 9 y regular en 3. CONCLUSIÓN: en esa serie de casos la facetectomía total unilateral no fue factor determinante de inestabilidad lumbar.OBJECTIVE: to determine the presence or absence of lumbar instability after the execution of unilateral total facetectomy for the root decompression. METHODS: the authors

  6. Depression with postpartum onset: a prospective cohort study in women undergoing elective cesarean section in Brasilia, Brazil Depressão com início após o parto: estudo de corte prospectivo em mulheres submetidas à cesárea eletiva em Brasília, Brasil

    Directory of Open Access Journals (Sweden)

    Alberto Moreno Zaconeta

    2013-03-01

    Full Text Available PURPOSE: It was to determine the prevalence of depressive symptoms in a sample of puerperal women from Brasília, Brazil, distinguishing cases with onset after delivery from those already present during pregnancy. METHODS: A prospective cohort study with convenience sampling of patients submitted to elective cesarean section at two private hospitals. As an instrument for assessing depressive symptoms, the Edinburgh Postnatal Depression Scale with cutoff >13 was applied shortly before delivery and four to eight weeks after childbirth. RESULTS: Among the 107 women who completed the study, 11 (10.3% had significant depressive symptoms during pregnancy and 12 (11.2% during the postpartum period. Among the 12 patients with postpartum symptoms, 6 had symptoms during pregnancy, so that 5.6% of the sample had postpartum onset of depression. The higher overall frequency of depression was significantly among single women than among married women (p=0.04, a fact mainly due to a higher frequency of single women experiencing persistent depressive symptoms both before and after delivery (p=0.002. The risk of depression was not influenced by age, parity or educational level. CONCLUSION: Women with depression identified during the postpartum period comprise a heterogeneous group, in which symptoms may have started before pregnancy, during pregnancy or after childbirth. In this sample, half of the postpartum depression cases already presented symptoms during late pregnancy. Since depression can arise before and after childbirth, it may have different etiologies and, therefore, a different response to treatment, a possibility that should be considered by clinicians and researchers.OBJETIVO: Foi determinar a prevalência de sintomas depressivos em uma amostra de puérperas da cidade de Brasília, Brasil, discriminando os casos com surgimento após o parto daqueles já presentes durante a gestação. MÉTODOS: Estudo de corte prospectivo. Amostragem por conveni

  7. Case Study: Revising a Formal Case Study Presentation as an Independent Research Project

    Science.gov (United States)

    Field, Patrick R.

    2013-01-01

    This article examines the process of researching and revising a case study presentation on an individual who experienced anesthetic awareness during an abdominal surgery and eventually committed suicide. Topics addressed include the author's selection of an undergraduate student with a science and teaching background to work on the case…

  8. Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1

    Directory of Open Access Journals (Sweden)

    Ammar Almaaytah

    2014-04-01

    Full Text Available There is great interest in the development of antimicrobial peptides as a potentially novel class of antimicrobial agents. Several structural determinants are responsible for the antimicrobial and cytolytic activity of antimicrobial peptides. In our study, a new synthetic peptide analog, AamAP1-Lysine from the naturally occurring scorpion venom antimicrobial peptide AamAP1, was designed by modifying the parent peptide in order to increase the positive charge and optimize other physico-chemical parameters involved in antimicrobial activity. AamAP1-Lysine displayed potent antibacterial activity against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration was in the range of 5 to 15 µM with a 10 fold increase in potency over the parent peptide. The hemolytic and antiproliferative activity of AamAP1-Lysine against eukaryotic mammalian cells was minimal at the concentration range needed to inhibit bacterial growth. The antibacterial mechanism analysis indicated that AamAP1-Lysine is probably inducing bacterial cell death through membrane damage and permeabilization determined by the release of β-galactosidase enzyme from peptide treated E. coli cells. DNA binding studies revealed that AamAP1-Lysine caused complete retardation of DNA migration and could display intracellular activities in addition to the membrane permeabilization mode of action reported earlier. In conclusion, AamAP1-Lysine could prove to be a potential candidate for antimicrobial drug development in future studies.

  9. AP1000核电厂氢气点火器功能分析%Analysis of AP1000 Hydrogen Igniter Performance

    Institute of Scientific and Technical Information of China (English)

    林千; 周全福

    2012-01-01

    A lumped parameter code was used to study the AP1000 hydrogen igniter system and demonstrate its performance. In the worst case defined in this paper, the maximum hydrogen release rate was up to 300 kg/min. The results show that, if no ignition is initiated, the hydrogen concentration in some compartment is very high, the gas is burnable and it may induce the deflagration to detonation transition (DDT). While igniters on, and the concentration is reduced below the lower flammable limits. These demonstrate that the igniter system can effectively reduce the risk of hydrogen in severe accident.%采用集总参数分析程序对AP1000核电厂安全壳内氢气点火系统功能进行了分析和验证.在定义的包络事故工况下,氢气最大瞬时释放速率达300 kg/min.计算表明:在无点火措施情况下,AP1000安全壳局部隔间的氢气浓度较高,隔间内的气体处于可燃状态,且接近爆燃向爆炸转变( DDT)状态;在实施点火措施情况下,氢气浓度得到有效控制,氢气点火系统能消除严重事故下氢气所引起的风险.

  10. The calcar screw in angular stable plate fixation of proximal humeral fractures - a case study

    Directory of Open Access Journals (Sweden)

    Simmen Hans-Peter

    2011-09-01

    Full Text Available Abstract Background With new minimally-invasive approaches for angular stable plate fixation of proximal humeral fractures, the need for the placement of oblique inferomedial screws ('calcar screw' has increasingly been discussed. The purpose of this study was to investigate the influence of calcar screws on secondary loss of reduction and on the occurrence of complications. Methods Patients with a proximal humeral fracture who underwent angular stable plate fixation between 01/2007 and 07/2009 were included. On AP views of the shoulder, the difference in height between humeral head and the proximal end of the plate were determined postoperatively and at follow-up. Additionally, the occurrence of complications was documented. Patients with calcar screws were assigned to group C+, patients without to group C-. Results Follow-up was possible in 60 patients (C+ 6.7 ± 5.6 M/C- 5.0 ± 2.8 M. Humeral head necrosis occurred in 6 (C+, 15.4% and 3 (C-, 14.3% cases. Cut-out of the proximal screws was observed in 3 (C+, 7.7% and 1 (C-, 4.8% cases. In each group, 1 patient showed delayed union. Implant failure or lesions of the axillary nerve were not observed. In 44 patients, true AP and Neer views were available to measure the head-plate distance. There was a significant loss of reduction in group C- (2.56 ± 2.65 mm compared to C+ (0.77 ± 1.44 mm; p = 0.01. Conclusions The placement of calcar screws in the angular stable plate fixation of proximal humeral fractures is associated with less secondary loss of reduction by providing inferomedial support. An increased risk for complications could not be shown.

  11. Tactile Astronomy - a Portuguese case study

    Science.gov (United States)

    Canas, L.; Alves, F.; Correia, A.

    2012-09-01

    Although astronomy plays an important role in the most various outreach initiatives, as well as school science curricula, due to its strong visual component in knowledge acquisition, astronomy subjects are not entirely well addressed and accessed by visually impaired students and/or general public. This stresses the need of more tactile material production, still very scarce in an educational context whether formal or informal. This is a case study activity developed based on different schematic tactile images of several objects present in our solar system. These images in relief, highlight, through touch, several relevant features present in the different astronomical objects studied. The scientific knowledge is apprehended through the use of a tactile key, complemented with additional information. Through proper hands-on activities implementation and careful analysis of the outcome, the adapted images associated with an explanatory key prove to be a valuable resource in tactile astronomy domain. Here we describe the process of implementing such initiative near visually impaired students. The struggles and challenges perceived by all involved and the enrichment experience of engaging astronomy with visually impaired audiences, broadening horizons in an overall experience accessible to all.

  12. Anorexia in the Adolescence - case study

    Directory of Open Access Journals (Sweden)

    Almeida de Paiva, Maria O

    2010-07-01

    Full Text Available Eating disorders lead to special biological and psychological states. The result of the total lack of food is treated in a distinct way by anorexia. Nutritionists have thus had difficulty in coming to an agreement on the best therapy to prevent such disorders. First it is essential to understand which treatment aims are and then to attempt to know how the several treatment models used nowadays can reach those aims. Someone who suffers from eating disorders, together with an inner deformation, suffers from too much sensitiveness. In order to solve these problems, one needs a change in the relationship with oneself, with the others and with the world. This study presents a teenager’s case study – Anorexia. Is, in fact, a problem that society faces and can’t ignore. Many youngsters have already died and others are following their steps. But there are also those ones that succeeded in overcoming the problem and now are reporting their stories.

  13. Odontoma: a retrospective study of 73 cases

    Energy Technology Data Exchange (ETDEWEB)

    An, Seo Young; An, Chang Hyeon; Choi, Karp Shik [School of Dentistry, Kyungpook National University, Daegu (Korea, Republic of)

    2012-06-15

    The purpose of the present study was to retrospectively evaluate the clinical findings and treatment results for impacted permanent teeth associated with odontomas. We retrospectively investigated 73 odontomas in 72 patients who visited Kyungpook National University Dental Hospital from April 2004 through November 2011. The study was performed using medical records, panoramic radiographs, and pathological reports. Data gathered included age, gender, location, chief complaints, effects on dentition, and treatment of odontoma and the impacted tooth associated with odontoma. Most compound odontomas (46.7%) were found in the second decade and complex odontomas were not related to age. Odontomas showed no gender predilection. Fifty-five cases (75.3%) of odontomas were detected on routine dental radiographs. Sixty percent of compound odontomas occurred in the canine area and 57.1% of complex odontomas in the molar areas. Impaction of permanent teeth (61.6%) was the most common complication on the adjacent teeth. Most odontomas (84.9%) were removed surgically and impacted permanent teeth were managed by surgical removal (53.2%), orthodontic treatment (25.5%), or surgical repositioning (6.4%). There was a statistically significant relation between age and preservation of the impacted permanent teeth associated with odontomas (p<0.01). Early detection and treatment of odontomas increase the possibility of preservation of the impacted tooth. Therefore, it would be suggested that periodic panoramic examination during the first and second decade of life might be beneficial for the early detection and better prognosis of odontomas.

  14. Go with the flow: A case study

    Energy Technology Data Exchange (ETDEWEB)

    Moran, J.A. [Alfred Hospital, Prahran, VIC (Australia)

    1998-03-01

    Full text: A 55-year-old female presented to the Alfred Emergency Department semi-conscious with frank rectal bleeding requiring blood volume replacement. Labelled red blood cell (RBC) scintigraphy was requested in order to locate the site of bleeding. In vitro labelling of 3 mL of patient``s blood was performed (PYP as a diluted tinning agent and 1 GBq of freshly eluted {sup 99}mTc) and suspended red cells were injected. Using a GE Starcam system with high resolution collimation, images were acquired for 30 seconds (2 s per frame) and thereafter continuously for 1. 5 hours (30 s per frame). During imaging, patient history became available revealing portal hypertension, oesophageal and anal varices due to myelofibrosis and previous cholecystectomy. Initial flow images showed bizarre abdominal collateral vessels. Accumulation of labelled RBC over 1.5 hours in the right upper quadrant indicated the hepatic flexure as the site of bleeding. The initial flow study showing major porto-systemic collateral vessels indicated that therapeutic embolisation via angiography would be life threatening. The patient underwent emergency hemicolectomy and has been bleed-free to date. In this case, delayed RBC scintigraphy accurately located the haemorrhage site. However, the initial flow study demonstrating major vessel collateral flow was crucial in contraindicating angiographic embolisation. Surgery was then the only therapeutic option.

  15. Antineutrino reactor safeguards - a case study

    CERN Document Server

    Christensen, Eric; Jaffke, Patrick

    2013-01-01

    Antineutrinos have been proposed as a means of reactor safeguards for more than 30 years and there has been impressive experimental progress in neutrino detection. In this paper we conduct, for the first time, a case study of the application of antineutrino safeguards to a real-world scenario - the North Korean nuclear crisis in 1994. We derive detection limits to a partial or full core discharge in 1989 based on actual IAEA safeguards access and find that two independent methods would have yielded positive evidence for a second core with very high confidence. To generalize our results, we provide detailed estimates for the sensitivity to the plutonium content of various types of reactors, including most types of plutonium production reactors, based on detailed reactor simulations. A key finding of this study is that a wide class of reactors with a thermal power of less than 0.1-1 GWth can be safeguarded achieving IAEA goals for quantitative sensitivity and timeliness with detectors right outside the reactor ...

  16. BOOK REVIEW: Case Studies in Knowledge Management

    Directory of Open Access Journals (Sweden)

    Reviewed by Dr. Adnan BOYACI

    2005-10-01

    Full Text Available 161Case Studies in Knowledge ManagementEdited by Murray JennexHersley: PA: Idea Group, 2005, pp. 372, ISBN 1-59140-352-9Reviewed by Dr. Adnan BOYACIAnadolu UniversityEskişehir-TurkeyKnowledge management (KM as a structured system and the way to the effectiveness isrelatively new field for the contemporary organizations functioning in different andcompetitive domain of public and private sectors in terms of getting optimal effectivenessunderlined by the concepts such as quality, productivity…etc. Because of the growingimportance and the popularity of the KM either as a research topic or specialized coursesubject, a crucial need for understanding, conceptualization and implementation of KM asa system has emerged since the mid 1990’s. In this sense, the book contributes criticallyto fill the gap between theory and implementation as a teaching material.This edited book is published by Idea Group Publishing. The book has twenty chaptersdivided into seven sections. In addition to a section of authors’ biography contributing thebook and an index, there is a preface that the basic terms and key concepts underliningthe cases discussed following chapters, which is explained in a schematized way.Besides the editor, total of 47 authors have contributed to the book. These authors arefrom different countries, academic backgrounds, and institutions. Although approximatelyone third of the authors are from USA, the rest of the authors are from Canada, England,Austria, Germany, Australia, New Zealand, Egypt, Bahrain and China. The authorsrepresent a variety of universities, private companies, and military institutions. Most ofthem have strong professional backgrounds, which help them address the issues bothfrom theoretical and practical perspectives. Contributions of authors having differentbackgrounds and institutions enable the book to have very comprehensive spectrum andthis makes the book attractive practically for those working different sectors

  17. Kepler observations of rapidly oscillating Ap, δ Scuti and γ Doradus pulsations in Ap stars

    DEFF Research Database (Denmark)

    Balona, Luis A.; Cunha, Margarida S.; Kurtz, Donald W.

    2011-01-01

    Observations of the A5p star KIC 8677585 obtained during the Kepler 10-d commissioning run with 1-min time resolution show that it is a rapidly oscillating Ap (roAp) star with several frequencies with periods near 10 min. In addition, a low frequency at 3.142 d−1 is also clearly present....... Multiperiodic γ Doradus (γ Dor) and δ Scuti (δ Sct) pulsations, never before seen in any Ap star, are present in Kepler observations of at least three other Ap stars. Since γ Dor pulsations are seen in Ap stars, it is likely that the low frequency in KIC 8677585 is also a γ Dor pulsation. The simultaneous...... presence of both γ Dor and roAp pulsations and the unexpected detection of δ Sct and γ Dor pulsations in Ap stars present new opportunities and challenges for the interpretation of these stars. Since it is easy to confuse Am and Ap stars at classification dispersions, the nature of these Ap stars...

  18. Guidelines for Conducting Positivist Case Study Research in Information Systems

    Directory of Open Access Journals (Sweden)

    Graeme Shanks

    2002-11-01

    Full Text Available The case study research approach is widely used in a number of different ways within the information systems community. This paper focuses on positivist, deductive case study research in information systems. It provides clear definitions of important concepts in positivist case study research and illustrates these with an example research study. A critical analysis of the conduct and outcomes of two recently published positivist case studies is reported. One is a multiple case study that validated concepts in a framework for viewpoint development in requirements definition. The other is a single case study that examined the role of social enablers in enterprise resource planning systems implementation. A number of guidelines for successfully undertaking positivist case study research are identified including developing a clear understanding of key concepts and assumptions within the positivist paradigm; providing clear and unambiguous definitions of the units and interactions when using any theory; carefully defining the boundary of the theory used in the case study; using hypotheses rather than propositions in the empirical testing of theory; using fuzzy or probabilistic propositions in recognising that reality can never be perfectly known; selecting case studies carefully, particularly single case studies; and recognising that generalisation from positivist, single case studies is inherently different from generalisation from single experiments. When properly undertaken, positivist, deductive case study research is a valuable research approach for information systems researchers, particularly when used within pluralist research programs that use a number of different research approaches from different paradigms.

  19. Teaching microbiological food safety through case studies

    Directory of Open Access Journals (Sweden)

    Florence Dubois-Brissonnet

    2015-10-01

    Full Text Available Higher education students usually ask for more training based on case studies. This was addressed by designing a specific food safety module (24 hours in which students were shown how to predict microbiological risks in food products i.e. they were asked to determine product shelf-life according to product formulation, preservation methods and consumption habits using predictive microbiology tools. Working groups of four students first identified the main microbiological hazards associated with a specific product. To perform this task, they were given several documents including guides for good hygiene practices, reviews on microbiological hazards in the food sector, flow sheets, etc…  After three-hours of work, the working groups prepared and gave an oral presentation in front of their classmates and professors. This raised comments and discussion that allowed students to adjust their conclusions before beginning the next step of their work. This second step consisted in the evaluation of the safety risk associated with the two major microbiological hazards of the product studied, using predictive microbiology. Students then attended a general lecture on the different tools of predictive microbiology and tutorials (6 hours that made them familiar with the modelling of bacterial growth or inactivation. They applied these tools (9 hours to predict the shelf-life of the studied product according to various scenarios of preservation (refrigeration, water activity, concentration of salt or acid, modified atmosphere, etc… and/or consumption procedures (cooking. The module was concluded by oral presentations of each working group and included student evaluation (3 hours.

  20. Stratification in Ap star atmospheres: Simulations

    Science.gov (United States)

    Cowley, Charles R.; Castelli, Fiorella

    2017-01-01

    It is now well established that the atmospheres of Ap stars can be chemically stratified (cf. Babel, A\\&A 258, 645, 1992; Ryabchikova et al. A\\&A 384, 545, 2002). The most convincing cases have been made with the profiles of very strong lines, such as Ca II K. Weaker line profiles are less obvious indicators. The collective behavior of sets or groups of lines have also been used. For example, if higher abundances are derived for strong lines in an atmosphere with zero microturbulence, one may assume that the absorbing species has been pushed into the higher photospheres. An example are the medium-strong Mn II lines in HgMn stars. In this paper, we probe this assumption by calculating line strengths with various assumed stratification models, and then determining abundances from those lines using an {\\bf unstratified} model with the same Teff and log(g). We use the model from Castelli, Kurucz \\& and Hubrig (A\\&A, 508, 401, 2009) for HR 6000, whose spectrum shows numerous indications of stratification. A variety of stratification models are considered, for example, ones where the majority of an absorbing species is concentrated above (or below) $log(\\tau_{5000}$ = -2.0. Cloud models are also investigated, where a species is concentrated within a range of photospheric depths. Curves of growth are generated in unstratified atmospheres for lines by holding the abundance fixed, and increasing log(gf). Similar curves are made in stratified models, and the ratios of strong to weak linesare compared with and without stratification. The effects of stratification on ionization are also investigated, as well as on the profiles of strong lines. We find, in agreement with previous work, that severe abundance jumps are sometimes required to account for some of the observed peculiarities.

  1. El uso de apósitos hidrocelulares de la gama Allevyn® en heridas agudas: Resultados a partir del estudio AURIGA-04 en Atención Primaria The use of Allevyn® hydrocellular dressings range in acute wounds-AURIGA-04 study in primary care

    Directory of Open Access Journals (Sweden)

    José Verdú Soriano

    2006-09-01

    el 63,9% de las heridas, en un promedio de 40,9 días. La superficie inicial de las lesiones mostró una reducción significativa a lo largo del seguimiento (inicial: 23,34 cm², final: 4,27 cm², p ≤ 0,001. En los modelos de regresión de Cox, sólo resultó estadísticamente significativa la edad del paciente, en el grupo de lesiones traumáticas (RR: -0,03, p= 0,039. Durante el período de seguimiento, un 80,3% de los pacientes fue tratado en combinación con Intrasite Conformable®, Iruxol Mono® o la combinación de ambos productos. Los profesionales que realizaron las curas con Allevyn® valoraron muy favorablemente su manejo durante todo el estudio; así, en más del 96% de los cambios se consideró fácil de colocar, en el 100% indoloro y también en el 100% de fácil retirada. A la vista de los resultados, los apósitos de CAH y, en concreto, la gama de apósitos Allevyn®, tienen una clara aplicación en el caso de las heridas agudas, permitiendo un óptimo abordaje local de las lesiones, proporcionando unos nivelesóptimos de humedad, pH y temperatura para las células implicadas en el proceso de cicatrización. Así, se promueve la formación de tejido de granulación y facilita la epitelización, además de proteger la herida ante traumatismos y gérmenes.Although moist environment dressings have mainly been used for chronic wounds, they can also be used on acute wounds in order to achieve an optimum atmosphere that facilitates epithelial migration, providing adequate protection for the wounds as well as good exudate management. Hence, as part of the AURIGA- 04 study, an observational study was carried out at different centres, involving repeated measures on a group of patients who presented diverse acute wounds, including patients with traumatic wounds, surgical wounds or burns treated by primary care professionals. The aim of this study was to find evidence about the use of moist environment dressings, specifically the Allevyn® range of

  2. Estrabismo após inflamação idiopática orbitária aguda na infância: relato de caso Strabismus after orbital inflammation in childhood: case report

    Directory of Open Access Journals (Sweden)

    Flávia Augusta Attié de Castro

    2004-02-01

    Full Text Available Em crianças, as inflamações orbitárias idiopáticas são extremamente raras e de difícil diagnóstico. O presente trabalho tem por objetivo descrever um caso de inflamação orbitária idiopática aguda em criança de um ano e um mês de idade, que evoluiu com importante seqüela oculomotora. Além do estudo de caso, discute-se o diagnóstico diferencial entre a celulite orbitária e as inflamações orbitárias idiopáticas e faz-se uma revisão da literatura sobre a ocorrência das inflamações orbitárias idiopáticas na infância.In children, idiopathic orbital inflammations are extremely rare and difficult to diagnose. The present study describes one case of idiopathic orbital inflammation in a one-year-old child that led to important oculomotor impairment. The differential diagnosis between idiopathic orbital inflammation and orbital cellulitis is discussed and the literature on the idiopathic orbital inflammation in childhood is reviewed.

  3. Case Study Research in Software Engineering Guidelines and Examples

    CERN Document Server

    Runeson, Per; Rainer, Austen; Regnell, Bjorn

    2012-01-01

    Based on their own experiences of in-depth case studies of software projects in international corporations, in this book the authors present detailed practical guidelines on the preparation, conduct, design and reporting of case studies of software engineering.  This is the first software engineering specific book on the case study research method.

  4. Generation solar case study : solar summer camp

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    This document presented a case study of the use of solar power at camp Tanamakoon in Ontario's Algonquin Park. It discussed camp facilities which include solar powered composting toilets and solar heated showers. Composting, recycling, and use of environmentally friendly products were also discussed. The camp also has a grid interactive solar electric system and a solar water heating system. The solar electric system provides backup power to critical loads such as safety lights and an emergency fridge and is also connected to the existing grid electricity system. Any excess energy from the solar system can be used by other kitchen appliances or, any other load anywhere in the camp. The main user of the solar heated water is a large automatic dishwasher which has as a built-in boost heater for those days when the solar heated water is insufficiently hot to sanitize dishes. It was concluded that while camp utility bills have been reduced by this investment in renewable energy technology, the primary objectives of the project were the protection of Tanamakoon's pristine Algonquin environment and the attraction and retention of clients for the camp by enhancing the camping experience. fig.

  5. Deep Energy Retrofits - Eleven California Case Studies

    Energy Technology Data Exchange (ETDEWEB)

    Less, Brennan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fisher, Jeremy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Walker, Iain [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-10-01

    This research documents and demonstrates viable approaches using existing materials, tools and technologies in owner-conducted deep energy retrofits (DERs). These retrofits are meant to reduce energy use by 70% or more, and include extensive upgrades to the building enclosure, heating, cooling and hot water equipment, and often incorporate appliance and lighting upgrades as well as the addition of renewable energy. In this report, 11 Northern California (IECC climate zone 3) DER case studies are described and analyzed in detail, including building diagnostic tests and end-use energy monitoring results. All projects recognized the need to improve the home and its systems approximately to current building code-levels, and then pursued deeper energy reductions through either enhanced technology/ building enclosure measures, or through occupant conservation efforts, both of which achieved impressive energy performance and reductions. The beyond-code incremental DER costs averaged $25,910 for the six homes where cost data were available. DERs were affordable when these incremental costs were financed as part of a remodel, averaging a $30 per month increase in the net-cost of home ownership.

  6. Hyperamonemia in children. Study of 72 cases

    Directory of Open Access Journals (Sweden)

    Jiménez Pérez Mario

    2014-07-01

    Full Text Available Hyperammonemia (HA is a metabolic emergency, and when not diagnosed and treated in a timely manner leads to severe neuro- logical damage and/ or death. HA may have multiple origins, but the EIM are one of the causes that should always be suspected. The objective of this work is to make a clinical description of the causes of HA in a sample of patients from the National Institute of Pediatrics (INP, to know the proportion of patients with HA in which could confirm the presence of an inborn error of metabolism (IEM. We found 72 patients with HA in the past 10 years, of whom 11 were patients already known to have an IEM and 61 with unknown cause; Of the latter, 46% of patients underwent metabolic studies (amino acids quantification, organic acids analysis and orotic acid quantification and in 14 cases (30% an IEM was diagnosed. The clinical symptoms most frequently observed were neurological (seizures, drowsiness, lethargy, irritability, developmental delay, and hypotonia stupor, etc., followed by digestive disturbances such as vomiting and refusal to eat. Urea cycle disorders, aminoacidopathies and organic acidemias were diagnosed, so the management and treatment of these should be known by the pediatricians, especially those dedicated to emergencies.

  7. Jazz improvisers’ shared understanding: A case study

    Directory of Open Access Journals (Sweden)

    Michael F. Schober

    2014-08-01

    Full Text Available To what extent and in what arenas do collaborating musicians need to understand what they are doing in the same way? Two experienced jazz musicians who had never previously played together played three improvisations on a jazz standard (It Could Happen to You on either side of a visual barrier. They were then immediately interviewed separately about the performances, their musical intentions, and their judgments of their partner’s musical intentions, both from memory and prompted with the audiorecordings of the performances. Statements from both (audiorecorded interviews as well as statements from an expert listener were extracted and anonymized. Two months later, the performers listened to the recordings and rated the extent to which they endorsed each statement. Performers endorsed statements they themselves had generated more often than statements by their performing partner and the expert listener; their overall level of agreement with each other was greater than chance but moderate to low, with disagreements about the quality of one of the performances and about who was responsible for it. The quality of the performances combined with the disparities in agreement suggest that, at least in this case study, fully shared understanding of what happened is not essential for successful improvisation. The fact that the performers endorsed an expert listener’s statements more than their partner’s argues against a simple notion that performers’ interpretations are always privileged relative to an outsider’s.

  8. Jazz improvisers' shared understanding: a case study.

    Science.gov (United States)

    Schober, Michael F; Spiro, Neta

    2014-01-01

    To what extent and in what arenas do collaborating musicians need to understand what they are doing in the same way? Two experienced jazz musicians who had never previously played together played three improvisations on a jazz standard ("It Could Happen to You") on either side of a visual barrier. They were then immediately interviewed separately about the performances, their musical intentions, and their judgments of their partner's musical intentions, both from memory and prompted with the audiorecordings of the performances. Statements from both (audiorecorded) interviews as well as statements from an expert listener were extracted and anonymized. Two months later, the performers listened to the recordings and rated the extent to which they endorsed each statement. Performers endorsed statements they themselves had generated more often than statements by their performing partner and the expert listener; their overall level of agreement with each other was greater than chance but moderate to low, with disagreements about the quality of one of the performances and about who was responsible for it. The quality of the performances combined with the disparities in agreement suggest that, at least in this case study, fully shared understanding of what happened is not essential for successful improvisation. The fact that the performers endorsed an expert listener's statements more than their partner's argues against a simple notion that performers' interpretations are always privileged relative to an outsider's.

  9. Case study for a vaccine against leishmaniasis.

    Science.gov (United States)

    Alvar, Jorge; Croft, Simon L; Kaye, Paul; Khamesipour, Ali; Sundar, Shyam; Reed, Steven G

    2013-04-18

    Leishmaniasis in many ways offers a unique vaccine case study. Two reasons for this are that leishmaniasis is a disease complex caused by several different species of parasite that are highly related, thus raising the possibility of developing a single vaccine to protect against multiple diseases. Another reason is the demonstration that a leishmaniasis vaccine may be used therapeutically as well as prophylactically. Although there is no registered human leishmaniasis vaccine today, immunization approaches using live or killed organisms, as well as defined vaccine candidates, have demonstrated at least some degree of efficacy in humans to prevent and to treat some forms of leishmaniasis, and there is a vigorous pipeline of candidates in development. Current approaches include using individual or combined antigens of the parasite or of salivary gland extract of the parasites' insect vector, administered with or without formulation in adjuvant. Animal data obtained with several vaccine candidates are promising and some have been or will be entered into clinical testing in the near future. There is sufficient scientific and epidemiological justification to continue to invest in the development of vaccines against leishmaniasis.

  10. Hybrid Risk Management Methodology: A Case Study

    Directory of Open Access Journals (Sweden)

    Jacky Siu-Lun Ting

    2009-10-01

    Full Text Available Risk management is a decision-making process involving considerations of political, social, economic and engineering factors with relevant risk assessments relating to a potential hazard. In the last decade, a number of risk management tools are introduced and employed to manage and minimize the uncertainty and threats realization to the organizations. However, the focus of these methodologies are different; in which companies need to adopt various risk management principles to visualize a full picture of the organizational risk level. Regarding to this, this paper presents a new approach of risk management that integrates Hierarchical Holographic Modeling (HHM, Enterprise Risk Management (ERM and Business Recovery Planning (BCP for identifying and assessing risks as well as managing the consequences of realized residual risks. To illustrate the procedures of the proposed methodology, a logistic company ABC Limited is chosen to serve as a case study Through applying HHM and ERM to investigate and assess the risk, ABC Limited can be better evaluated the potential risks and then took the responsive actions (e.g. BCP to handle the risks and crisis in near future.

  11. Solar wind correlations: Statistical and case studies

    Science.gov (United States)

    Paularena, K. I.; Richardson, J. D.; Zastenker, G. N.; Dalin, P. A.

    1999-06-01

    Recent work on solar wind plasma correlations using data from several widely-separated spacecraft (IMP 8, INTERBALL-1, WIND, and ISEE-3) has shown that, for 6-hour periods, the average plasma correlation is ~0.7. The focus of these studies has been directed toward a statistical understanding of gross solar wind correlation behavior. In all correlations examined, lower average correlations are caused by the presence of many points from the low correlation subpopulation; nevertheless, data points from the high correlation population are still present. No single organizational factor has yet been found which adequately separates low-correlation periods from high-correlation periods. Some of the spread in correlations is due to the spatial orientations and dimensions of solar wind structures, and thus to the locational alignments of the spacecraft being correlated, but this does not adequately explain all the good or poor correlations since sometimes three nearby spacecraft show poor correlations, while sometimes three widely-separated space-craft show good correlations. Thus, in order to understand the underlying physics, detailed investigation of individual cases has been undertaken. These results will be important in assigning quality measures to space weather predictions using satellite measurements taken at L1, for example.

  12. Dynamic optimization case studies in DYNOPT tool

    Science.gov (United States)

    Ozana, Stepan; Pies, Martin; Docekal, Tomas

    2016-06-01

    Dynamic programming is typically applied to optimization problems. As the analytical solutions are generally very difficult, chosen software tools are used widely. These software packages are often third-party products bound for standard simulation software tools on the market. As typical examples of such tools, TOMLAB and DYNOPT could be effectively applied for solution of problems of dynamic programming. DYNOPT will be presented in this paper due to its licensing policy (free product under GPL) and simplicity of use. DYNOPT is a set of MATLAB functions for determination of optimal control trajectory by given description of the process, the cost to be minimized, subject to equality and inequality constraints, using orthogonal collocation on finite elements method. The actual optimal control problem is solved by complete parameterization both the control and the state profile vector. It is assumed, that the optimized dynamic model may be described by a set of ordinary differential equations (ODEs) or differential-algebraic equations (DAEs). This collection of functions extends the capability of the MATLAB Optimization Tool-box. The paper will introduce use of DYNOPT in the field of dynamic optimization problems by means of case studies regarding chosen laboratory physical educational models.

  13. Refugee Problem in Europe – Case Studies

    Directory of Open Access Journals (Sweden)

    Esztella Varga

    2015-11-01

    Full Text Available The European refugee problem has grown dramatically in the last few months, putting a considerable amount of pressure on the European countries. Not only are they facing migrants from North Africa, but from the Middle East as well.In March 2011 the Arab Spring has reached Syria, causing a huge number of Syrians to flee their country and seek asylum in Turkey, and possibly going further to the EU. The refugees who fled Syria as well as those who are leaving North Africa (mostly the failed state of Libya are aiming to reach European soil, but Italy, Greece or Turkey is not ready to handle the amount of refugees. The cooperation of the Mediterranean countries and Europe has not been able to slow down the flow of refugees, and the Mediterranean and Aegean seas have become dangerous routes for the desperate migrants who attempt the sea-crossing. In my analysis I would like to highlight the role of the so-called elements of ‘soft power’ in the way of dealing with the refugee problem. According to my hypothesis, the issue can’t be successfully addressed using only the means of the ‘soft power’. No real solution for the crisis has been offered yet, and I would like to give case studies of the different ways of dealing with the problem – inside (Greece, Italy and outside (Turkey of the European Union.

  14. Environmental injustice: case studies from the South

    Energy Technology Data Exchange (ETDEWEB)

    Cifuentes, Enrique [Pediatric Environmental Health Specialty Unit, National Institute of Public Health, Mexico Environmental Sciences, Av Universidad 655, Cuernavaca CP 62508 (Mexico); Frumkin, Howard [National Centre Environmental Health, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, 1600 Clifton Road MS E-28, Atlanta, GA 30333 (United States)

    2007-10-15

    We selected three case studies to illustrate environmental injustice issues in the South. These examples relate to migrant agricultural workers, the maquiladora industry and artisanal mining, while reviewing some of the major mechanisms involved, e.g. multinational corporations, the development of free trade zones, multilateral free trade agreements and the export of hazards. A series of strategies are discussed in order to address environmental injustice and health disparities that exist on a global scale. Some of the recommendations involve policy initiatives; others, such as research and mentorship, fall within the traditional domain of public health practice. In this paper, special attention is given to concerned environmental and occupational health professionals using evidence-based data for advocacy. For lasting changes to be made, however, stronger institutions and legislation are required. Those who have the 'right to know' about environmental injustice issues include communities of concern, workers' representatives and lawyers. Government officials and company officials may eventually work on the basis of conflict resolution, compensation and remediation, to quote some examples. Systematic approaches to protect both the environment and public health must be updated.

  15. Environmental injustice: case studies from the South

    Science.gov (United States)

    Cifuentes, Enrique; Frumkin, Howard

    2007-10-01

    We selected three case studies to illustrate environmental injustice issues in the South. These examples relate to migrant agricultural workers, the maquiladora industry and artisanal mining, while reviewing some of the major mechanisms involved, e.g. multinational corporations, the development of free trade zones, multilateral free trade agreements and the export of hazards. A series of strategies are discussed in order to address environmental injustice and health disparities that exist on a global scale. Some of the recommendations involve policy initiatives; others, such as research and mentorship, fall within the traditional domain of public health practice. In this paper, special attention is given to concerned environmental and occupational health professionals using evidence-based data for advocacy. For lasting changes to be made, however, stronger institutions and legislation are required. Those who have the 'right to know' about environmental injustice issues include communities of concern, workers' representatives and lawyers. Government officials and company officials may eventually work on the basis of conflict resolution, compensation and remediation, to quote some examples. Systematic approaches to protect both the environment and public health must be updated.

  16. Actinic Prurigo Cheilitis: A Clinicopathologic Review of 75 Cases.

    Science.gov (United States)

    Plaza, Jose A; Toussaint, Sonia; Prieto, Victor G; Mercadillo, Patricia; Diez de Medina, Juan C; Lourenco, Silvia; Batdorf, Bjorn; Sangueza, Martin

    2016-06-01

    Actinic prurigo (AP) is a chronic idiopathic photodermatosis that primarily affects American Indians in the United States and Mestizos in Latin American countries. Clinically, the onset of the disease is usually in the first decade of life but may appear initially in adult life, and it is characterized by symmetric involvement of sun-exposed areas of the skin, particularly areas of the face, resulting in polymorphic erythematous papules, macules, and plaques in different stages of evolution. Lower lip involvement includes swelling, scaling, fissures, hyperpigmentation, and ulcerations of the vermilion border. and in some cases could represent the only manifestation of the disease. The histopathologic features of AP have been studied; however, there is a controversy regarding whether AP cheilitis has distinct histopathologic features that could allow accurate separation from other specific and nonspecific forms of cheilitis. The diagnosis can be challenging, mainly when lip lesions are the only manifestation of the disease. In this study, the authors investigate the clinicopathologic features of 75 cases of AP cheilitis to provide further criteria for its diagnosis and classification. All 75 patients presented with lip lesions. Thirty-three cases were diagnosed as AP cheilitis with cutaneous lesions and 42 cases were diagnosed as AP cheilitis without cutaneous lesions (only lip lesions). Histologically, of the 33 cases with AP cheilitis with cutaneous lesions, 17 (52%) cases showed follicular cheilitis, and of the 42 cases that had only lip lesions, 18 (43%) cases showed follicular cheilitis. Histologically, AP cheilitis can present as follicular cheilitis; thus, supporting the diagnosis. Also, our findings confirm that lip lesions can present as the only manifestation of the disease, showing typical histological and clinical features. This form of cheilitis has not being well described in the dermatologic and dermatopathologic literature.

  17. Bilingual education in Slovakia: A Case Study

    Directory of Open Access Journals (Sweden)

    Silvia Pokrivčáková

    2013-06-01

    Full Text Available Bilingual education is one of the areas in contemporary education that brings out some important controversies (philosophical, conceptual, sociological, political, economical, etc. and thus calls for extensive and intensive debate. Bilingual education in Europe (and here the European Union countries are meant has gained a very different status, due to the general European policy of developing language diversity and promoting “European plurilingualism and multilingualism”. In Slovakia, one of the younger members of the EU, bilingual education became an extraordinarily popular instrument for the fulfilment of this task.  Since the specifically defined topic of bilingual education and its current status in Slovakia has not been studied and systematically reviewed yet, the research presented in this paper was designed as a single-phenomenon revelatory case study investigating seven research areas: reflection of bilingual education in school legislation and state pedagogical documents, purposes of bilingual education in Slovakia, its organization (levels and types of schools, foreign languages incorporated, teachers, structure of bilingual schools curricula, types of bilingual education applied at Slovak bilingual schools, and how bilingual education is both reflected in and saturated by the latest research findings. The conclusions presented in the paper were collected from multiple sources: state curriculum, statistical data published by the Slovak Ministry of Education or its partner institutions, international treaties on establishing and supporting bilingual sections of schools, bilingual schools curricula, interviews with school directors, teachers, and learners, direct observations at bilingual schools, research studies and research reports, etc. In the conclusion, bilingual education in Slovakia is identified as a unique, dynamically developing system which is both significantly shaped by the foreign language education policy promoted by

  18. Cases for the Net Generation: An Empirical Examination of Students' Attitude toward Multimedia Case Studies

    Science.gov (United States)

    Sheppard, Michael; Vibert, Conor

    2016-01-01

    Case studies have been an important tool in business, legal, and medical education for generations of students. Traditional text-based cases tend to be self-contained and structured in such a way as to teach a particular concept. The multimedia cases introduced in this study feature unscripted web-hosted video interviews with business owners and…

  19. Case Study: What Makes a Good Case, Revisited: The Survey Monkey Tells All

    Science.gov (United States)

    Herried, Clyde Freeman; Prud'homme-Genereux, Annie; Schiller, Nancy A.; Herreid, Ky F.; Wright, Carolyn

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. In this month's issue the authors provide a more definitive answer to the "What Makes a Good Case?" question based on a just-completed Survey Monkey survey given to NCCSTS teachers.

  20. In Case You Are Interested: Results of a Survey of Case Study Teachers

    Science.gov (United States)

    Herreid, Clyde Freeman; Schiller, Nancy A.; Herreid, Ky F.; Wright, Carolyn

    2011-01-01

    Case study teaching had a long tradition in law and business before it made the jump to medical school education in the form of Problem-Based Learning (PBL) in the 1970s. Today, both the University of Delaware's Clearinghouse and the University of Buffalo's National Center for Case Study Teaching in Science (NCCSTS) have hundreds of cases and…

  1. Estudo histopatológico da retina de coelhos após injeção intravítrea de lidocaína Histopathologic study of the retina in rabbits after intravitreous injection of lidocaine

    Directory of Open Access Journals (Sweden)

    Marcos Antônio Ferreira

    2002-01-01

    Full Text Available Objetivo: Estudar em olhos de coelhos as alterações retinianas após injeção intravítrea de lidocaína nas concentrações 0,5, 1,0 e 2,0% por meio de análise histopatológica com microscopias de luz e eletrônica de transmissão. Métodos: Foram utilizados 40 olhos de 20 coelhos albinos da raça Nova Zelândia, submetidos à injeção intravítrea de lidocaína a 0,5% (grupo II, 1,0% (grupo III e 2,0% (grupo IV nos olhos direitos e solução salina nos olhos esquerdos (grupo I-controle após anestesia geral. Foi realizada oftalmoscopia binocular indireta, antes, durante, imediatamente e uma hora após a injeção intravítrea e nos dias 1º, 3º, 7º e 15º de evolução. Nos mesmos períodos um olho do grupo II, dois olhos do grupo III, um olho do grupo IV e todos olhos contralaterais (grupo I, foram enucleados e examinados sob microscopia de luz e eletrônica de transmissão. Resultados: A observação por oftalmoscopia binocular indireta antes e durante a injeção intravítrea não apresentou alteração em todos os olhos examinados. Após a injeção intravítrea observou-se a retina com aspecto esbranquiçado difuso, elevação da interface vítreo-retiniana, focal e próximo ao local de injeção, edema de retina e anel de condensação vítrea tanto no grupo controle quanto nos olhos com injeção de lidocaína. A análise histológica por microscopia de luz e eletrônica de transmissão não evidenciou alterações em nenhum dos olhos examinados. Conclusões: A injeção intravítrea de lidocaína nas concentrações de 0,5, 1,0 e 2,0% demonstrou ser atóxica para a retina, considerando os estudos de microscopia de luz e eletrônica de transmissão.Purpose: To study the retinal alterations in rabbit eyes after intravitreal injection of 0.5, 1.0 and 2.0% lidocaine through histopathological analysis with light and transmission electron microscopy. Methods: Forty eyes of 20 New Zeland albino rabbits were submitted to intravitreal

  2. Jane: A Case Study in Anorexia Nervosa.

    Science.gov (United States)

    Willingham, Barbara

    1988-01-01

    The article reports the case history of a 15-year-old Australian girl with anorexia nervosa. Information is also given on prevalence, causes, definitions, and treatments including hospitalization, co-therapy, psychotherapy, behavior modification, family therapy, and counseling. (DB)

  3. Mathematical modelling with case studies using Maple and Matlab

    CERN Document Server

    Barnes, B

    2014-01-01

    Introduction to Mathematical ModelingMathematical models An overview of the book Some modeling approaches Modeling for decision makingCompartmental Models Introduction Exponential decay and radioactivity Case study: detecting art forgeries Case study: Pacific rats colonize New Zealand Lake pollution models Case study: Lake Burley Griffin Drug assimilation into the blood Case study: dull, dizzy, or dead? Cascades of compartments First-order linear DEs Equilibrium points and stability Case study: money, money, money makes the world go aroundModels of Single PopulationsExponential growth Density-

  4. Do case studies mislead about the nature of reality?

    Science.gov (United States)

    Pattison, S; Dickenson, D; Parker, M; Heller, T

    1999-02-01

    This paper attempts a partial, critical look at the construction and use of case studies in ethics education. It argues that the authors and users of case studies are often insufficiently aware of the literary nature of these artefacts: this may lead to some confusion between fiction and reality. Issues of the nature of the genre, the fictional, story-constructing aspect of case studies, the nature of authorship, and the purposes and uses of case studies as "texts" are outlined and discussed. The paper concludes with some critical questions that can be applied to the construction and use of case studies in the light of the foregoing analysis.

  5. Phyllodes tumor in adolescent. Case study.

    Directory of Open Access Journals (Sweden)

    Lidia Torres Aja

    2008-04-01

    Full Text Available Presentation of the case of a patient (18 years old who was assisted in the provincial mastology consultation for a non painful tumor, of sudden growth covering almost all the right breast, without other symptom or sing. After some tests, it was decided to operate. The tumor turned to be benign phyllodes. The relevance of this case lies in the infrequent appearance of this type of tumor, being even the first to be operated in our hospital.

  6. Center for Geometrisk Metrologi CGM ApS, Årsberetning 2001 til DANAK

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    Denne årsberetning omfatter CGM ApS' akkrediterede virksomhed i kalenderåret 2001. Årsberetningen er udarbejdet til DANAK (Dansk Akkreditering, Erhvervsfremme Styrelsen), som led i opfyldelsen af laboratoriets informationspligt i henhold til gældende regler (Teknisk Forskrift Nr. TF4 af 2000...

  7. AP1000, a nuclear central of advanced design; AP1000, una central nuclear de diseno avanzado

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez M, N.; Viais J, J. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: nhm@nuclear.inin.mx

    2005-07-01

    The AP1000 is a design of a nuclear reactor of pressurized water (PWR) of 1000 M We with characteristic of safety in a passive way; besides presenting simplifications in the systems of the plant, the construction, the maintenance and the safety, the AP1000 is a design that uses technology endorsed by those but of 30 years of operational experience of the PWR reactors. The program AP1000 of Westinghouse is focused to the implementation of the plant to provide improvements in the economy of the same one and it is a design that is derived directly of the AP600 designs. On September 13, 2004 the US-NRC (for their initials in United States- Nuclear Regulatory Commission) approved the final design of the AP1000, now Westinghouse and the US-NRC are working on the whole in a complete program for the certification. (Author)

  8. The Analysis of a Murder, a Case Study

    Science.gov (United States)

    Dinan, Frank J.; Szczepankiewicz, Steven H.; Carnaham, Melinda; Colvin, Michael T.

    2007-01-01

    The analysis of a Murder case study can be used in general chemistry or nonscience major chemistry courses to teach data handling and analysis in a non-laboratory context. This case study will help students to respond more enthusiastically and with more interest to a set of material placed before them related to a real case rather than…

  9. Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns

    Science.gov (United States)

    Meulemans, Daniel; Bronner-Fraser, Marianne

    2002-01-01

    The neural crest is a uniquely vertebrate cell type present in the most basal vertebrates, but not in cephalochordates. We have studied differences in regulation of the neural crest marker AP-2 across two evolutionary transitions: invertebrate to vertebrate, and agnathan to gnathostome. Isolation and comparison of amphioxus, lamprey and axolotl AP-2 reveals its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by neural crest cells early in vertebrate evolution. Expression in non-neural ectoderm is a conserved feature in amphioxus and vertebrates, suggesting an ancient role for AP-2 genes in this tissue. There is also common expression in subsets of ventrolateral neurons in the anterior neural tube, consistent with a primitive role in brain development. Comparison of AP-2 expression in axolotl and lamprey suggests an elaboration of cranial neural crest patterning in gnathostomes. However, migration of AP-2-expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive feature retained in all vertebrates. Because AP-2 has essential roles in cranial neural crest differentiation and proliferation, the co-option of AP-2 by neural crest cells in the vertebrate lineage was a potentially crucial event in vertebrate evolution.

  10. A clinico-pathological study of 70 cases of pemphigus

    Directory of Open Access Journals (Sweden)

    Arya S

    1999-01-01

    Full Text Available A clinicopalhological study of 70 cases of pemphigus observed over a span of four and a half years from January 1992 to June 1996 at the Sir J.J. Group of Hospitals and Grant Medical College, Mumbai is reported. Pemphigus vulgaris constituted the single largest group of 43 cases, followed by pemphigus foliaceus (25 cases and pemphigus vegetans (2 cases. Majority of the cases were seen in the age group of 21-60 years, with a slight male predominance. The youngest patient was 14 years while the eldest was aged 75 years. Mucosal involvement was seen in 31 cases of pemphigus vulgaris, as opposed to only 5 cases of pemphigus foliaceus. Flaccid bullae were present in 100% cases. Pruritus was complained of in 14 cases, though it was more common in pemphigus vegetans and vulgaris. Salient histopathological features of pemphigus vulgaris observed were (I intraepidermal suprabasal blisters (35 cases, (2 presence of acantholytic cells (40 cases, (3 "Row of tombstone appearance" (I8 cases and (4 acantholysis involving follicular sheath (20 cases. Main histopathological features of pemphigus foliaceus were (1 subcorneal blister (15 case, (2 acantholysis (24 cases and (3 bulla cavity containing inflammatory infiltrate (12 cases. Both cases of pemphigus vegetans showed hyperkeratosis, papillomatosis and irregular acanthosis with intra-epidermal eosinophilic abscesses besides suprabasal lacunae.

  11. Formalistic approaches to A&P

    Institute of Scientific and Technical Information of China (English)

    赵倩

    2014-01-01

    A&P is a famous short story. Its simple words, the unique point of view and skillful writing technique are expressed successfully. Besides, the first-person narrator is also a good point. From Sammy’s eyes, readers can learn the character’s characteristics. Another point is the usage of symbol, the name of the store, A&P, it shows that people’s life is rich, but their spirit is barren. This article tries to analyze it by formalistic approaches.

  12. AP calculus AB/BC

    CERN Document Server

    Schwartz, Stu

    2013-01-01

    All Access for the AP® Calculus AB & BC Exams Book + Web + Mobile Everything you need to prepare for the Advanced Placement® exam, in a study system built around you! There are many different ways to prepare for an Advanced Placement® exam. What's best for you depends on how much time you have to study and how comfortable you are with the subject matter. To score your highest, you need a system that can be customized to fit you: your schedule, your learning style, and your current level of knowledge. This book, and the free online tools that come with it, will help you personalize your AP® Cal

  13. A Case for Adjusting Subjectively Rated Scores in the Advanced Placement Tests. Program Statistics Research. Technical Report No. 94-5.

    Science.gov (United States)

    Longford, Nicholas T.

    A case is presented for adjusting the scores for free response items in the Advanced Placement (AP) tests. Using information about the rating process from the reliability studies, administrations of the AP test for three subject areas, psychology, computer science, and English language and composition, are analyzed. In the reliability studies, 299…

  14. Antenatal stress: An Irish case study.

    LENUS (Irish Health Repository)

    Carolan-Olah, Mary

    2013-05-16

    BACKGROUND:: stress in pregnancy is common and impacts negatively on women, infants and families. A number of factors contribute to high levels of stress in pregnancy, including financial concerns, marital discord, low support systems and low socio-economic status. OBJECTIVES:: the aim of this study was to evaluate stress anxiety levels and depressive symptoms among low risk women in an area in Ireland that was particularly impacted by the 2008 economic crisis. DESIGN:: a quantitative descriptive cross-sectional design was used. Data were collected using the Edinburgh Postnatal Depression Scale (EPDS), the Perceived Stress Scale and the State Trait Anxiety Inventory (STAI). Data was collected at a single time during the second trimester. SETTING:: this paper reports a case study of one maternity service in Ireland. Participants included low risk pregnant women who were attending the hospital clinic for routine antenatal care. RESULTS:: of 150 questionnaires distributed, 74 completed questionnaires were returned indicating a 49.3% return rate. Findings indicated high levels of stress, anxiety and depressive symptomatology among participants. There were no significant difference in mean EPDS score for different age groups (F4,69=2.48, P=0.052), living arrangements (F4,68=0.90, P=0.5) or usual occupation (F4,69=1.45, P=0.2). A score of ≥12 was taken as indicative of probable antenatal depression and 86.5% of participants responded with a score of 12 or above. PSS scores were also high and more than three quarters of respondents scored ≥15 (75.6%) and more than a third had scores ≥20 (35.1%), out of a total score of 40. There was a significant difference in mean PSS score between the different age groups (F4,69=3.60, P=0.010) but not for living arrangements or usual occupation. A STAI score of ≥39 was taken as indicative of antenatal anxiety, and 74.3% of participants responded with a score of 39 or above. There were no significant differences in mean STAI

  15. Studies on five cases of radiation enterocolitis

    Energy Technology Data Exchange (ETDEWEB)

    Yasunaga, Akira; Shibata, Okihiko; Kubo, Hironobu; Tomonari, Kazuhide; Hadama, Tetsuo; Uchida, Yuzou; Shirabe, Joji (Oita Medical Coll. (Japan))

    1990-05-01

    Five patients with radiation enterocolitis who were surgically treated are reported. The 5 patients had received irradiation therapy more than 5,000 rad for ginecologic malignancies. The period for the onset of symptoms of irradiation enteritis ranged from 8 months to 20 years however, 3 of them developed the symptoms within one year after irradiation therapy. Emergency surgery was carried out for bowel obstruction in 3 cases and for intestinal perforation in 2 cases. Bowel resection and primary anastomosis were performed by a one-step approach in 4 of them. Transient colostomy as preventive measure was added in 2 cases. It is very important for the one-step approach to resect the intestine at the healthy part far from the lesion of irradiation enteritis and to add a transient colostomy to prevent anastomolic insufficiency. Furthermore, suture material should be used less tissue reactive one. (author).

  16. General Aviation Weather Encounter Case Studies

    Science.gov (United States)

    2012-09-01

    off.under.marginal.visual.flight.rules.(MVFR),.and.one. took.off.under.instrument.flight.rules.( IFR ) ..When.the. 24.cases.were.stratified.by.phase.of.flight...the.only.evidence.the.pilot. would.have.had.was.from.his.data-linked.NEXRAD;.this. case.had.AIRMETs.out.for.MTOS,. IFR ,.and.moderate. turbulence...AIRMETs issued for IFR and turbulence during this time and location (not shown). Panel b: “Zoom-in” of radar summary (composite reflectivity) with

  17. Complicações e condutas fisioterapêuticas após cirurgia por câncer de mama: estudo retrospectivo Complications and physical therapeutic treatment after breast cancer surgery: a retrospective study

    Directory of Open Access Journals (Sweden)

    Simony Lira do Nascimento

    2012-09-01

    Full Text Available Após cirurgia por câncer de mama, as mulheres estão sujeitas a desenvolver algumas complicações físicas. Os objetivos deste trabalho foram: investigar o desfecho dessas mulheres, que, durante o primeiro mês pós-operatório, foram submetidas a um programa de reabilitação e identificar ao longo de dois anos as complicações mais frequentes e as condutas fisioterapêuticas mais adotadas. Foi um estudo descritivo, retrospectivo, com dados de 707 prontuários de mulheres operadas por câncer de mama no Hospital da Mulher Professor Doutor José Aristodemo Pinotti da Universidade Estadual de Campinas, entre janeiro de 2006 e dezembro de 2007, atendidas pelo Setor de Fisioterapia. A análise foi feita por meio de médias, desvio padrão e frequências absolutas e relativas. Ao final do programa, 55% das mulheres receberam alta, 17% necessitaram de atendimento adicional e 26% não aderiram a ele. As complicações mais frequentes foram: aderência pericicatricial (26%, restrição da amplitude de movimento (24% e deiscência cicatricial (17%. No primeiro ano após a cirurgia (n=460, foram relatados dor (28,5%, sensação de peso (21,5% e restrição da amplitude de movimento do ombro (16,7%; já no segundo (n=168, houve dor (48,2%, sensação de peso (42,8% e linfedema (23,2%. Concluiu-se que, ao final do programa, a maioria das mulheres recebeu alta. Ao longo dos anos, houve redução da frequência de restrição da amplitude de movimento do ombro com aumento de linfedema. Cuidados com o braço, exercícios domiciliares e autodrenagem foram as condutas mais adotadas.After breast cancer surgery, women may develop some physical complications. Thus, the aims of this study were to investigate the outcome of these women, who participated in a rehabilitation program for one month, as well to identify along two years the most frequent complications and adopted physical therapy conducts. It was a descriptive and retrospective study with 707 medical

  18. DDACE cogeneration systems : 10 case studies

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    DDACE Power Systems are experts in green energy power generation and provide solutions that deal with waste and industrial by-products. The company develops practical energy solutions that address environmental and financial concerns facing both industrial and municipal customers. The following 10 case studies are examples of the installations that DDACE Power Systems have completed in recent years: (1) a combined heat and emergency power installation on the roof of a 19 storey apartment building on Bloor Street in Toronto, Ontario. The cogeneration package provides electricity and heat to the entire building, replacing an old diesel generator, (2) a combined heat and emergency power installation at the Villa Colombo extended care facility in Vaughan, Ontario. The cogeneration system provides heat and power to the building, as well as emergency power, (3) emergency standby power with demand response capabilities at Sobeys Distribution Warehouse in Vaughan, Ontario. The primary purpose of the 2.4 MW low emission, natural gas fuelled emergency standby generator is to provide emergency power to the building in the event of a grid failure, (4) a dual fuel combined heat and power installation at the Queensway Carleton Hospital in Ottawa, Ontario that provides electricity, hot water and steam to all areas of the hospital, (5) a tri-generation installation at the Ontario Police College in Aylmer, Ontario which provides power and heat to the building as well as emergency power in the event of a grid failure. An absorption chiller provides cooling in the summer and an exhaust emission control system reduces NOx emissions, (6) a biomass gasification installation at Nexterra Energy in Kamloops, British Columbia. The 239 kW generator is fueled by synthesis gas, (7) biogas utilization at Fepro Farms in Cobden, Ontario for treatment of the facility's waste products. The biogas plant uses cow manure, as well as fats, oil and grease from restaurants to produce electricity and

  19. Case studies: Soil mapping using multiple methods

    Science.gov (United States)

    Petersen, Hauke; Wunderlich, Tina; Hagrey, Said A. Al; Rabbel, Wolfgang; Stümpel, Harald

    2010-05-01

    Soil is a non-renewable resource with fundamental functions like filtering (e.g. water), storing (e.g. carbon), transforming (e.g. nutrients) and buffering (e.g. contamination). Degradation of soils is meanwhile not only to scientists a well known fact, also decision makers in politics have accepted this as a serious problem for several environmental aspects. National and international authorities have already worked out preservation and restoration strategies for soil degradation, though it is still work of active research how to put these strategies into real practice. But common to all strategies the description of soil state and dynamics is required as a base step. This includes collecting information from soils with methods ranging from direct soil sampling to remote applications. In an intermediate scale mobile geophysical methods are applied with the advantage of fast working progress but disadvantage of site specific calibration and interpretation issues. In the framework of the iSOIL project we present here some case studies for soil mapping performed using multiple geophysical methods. We will present examples of combined field measurements with EMI-, GPR-, magnetic and gammaspectrometric techniques carried out with the mobile multi-sensor-system of Kiel University (GER). Depending on soil type and actual environmental conditions, different methods show a different quality of information. With application of diverse methods we want to figure out, which methods or combination of methods will give the most reliable information concerning soil state and properties. To investigate the influence of varying material we performed mapping campaigns on field sites with sandy, loamy and loessy soils. Classification of measured or derived attributes show not only the lateral variability but also gives hints to a variation in the vertical distribution of soil material. For all soils of course soil water content can be a critical factor concerning a succesful

  20. Olympus Imaging Fraud Scandal: A Case Study

    Science.gov (United States)

    Elam, Dennis; Madrigal, Marion; Jackson, Maura

    2014-01-01

    This case examines the two decade long tobashi scheme by Olympus Imaging Executives to hide $1.7 billion in losses. In the 1980s, a soaring yen and falling dollar caused bottom line income problems for many Japanese companies. Some companies sought to offset the declining revenue with zaiteku, a form of speculative investment. While early…

  1. Tuberculosis of breast (study of 7 cases.

    Directory of Open Access Journals (Sweden)

    Sharma P

    1991-01-01

    Full Text Available Seven cases of tuberculosis of breast are presented. The clinical features were multiple discharging sinuses, lump, ulcer and recurring abscess of breast. Diagnosis relied on histological appearance. Acid fast bacilli being present in only one specimen and positive culture obtained in one patient. Successful treatment combines antituberculous drug therapy with removal of infected breast tissue.

  2. Child Survivor of War: A Case Study

    Science.gov (United States)

    Roysircar, Gargi

    2004-01-01

    This article examines the history of a Bosnian survivor of war living in the U.S. using the extended case method. Clinical issues related to acculturative stress, posttraumatic stress disorder, and identity are analyzed. Suggested treatment includes existential therapy and its cognitive--behavioral applications, didactic education on trauma,…

  3. Mucocele - A study of 36 cases

    Directory of Open Access Journals (Sweden)

    Jani Dhaval

    2010-01-01

    Full Text Available Background: Mucocele is one of the most common benign soft tissue tumor present in the oral cavity. They are of two types - one is extravasation and second one is retention type but the majority are extravasation type. Aims: The objective is to determine various factors related to mucocele such as role of trauma due to nearby teeth, recurrence, duration, and to find out whether there is any role of psychological stress which initiates trauma like lip or cheek biting. Materials and Methods: 36 cases of mucocele diagnosed at the Department of the Oral Pathology, Govt. Dental College and Hospital, Ahmedabad, between 2004 and 2008 were reviewed. The clinical data were recorded and histopathologic diagnosis was made. Statistical Analysis Used: Data analysis tool, Microsoft Office Excel 2007. Results: A diagnosis of mucocele was established in 36 cases with male-to-female ratio of 1.77:1. Most common type was extravasation in 30 (83.33% cases. The peak age of occurrence was between 1st and 3rd decade. Lateral side of the lower labial mucosa was the most affected site in 34 (94.44% cases. The history of trauma appeared the major etiological factor seen in 28 (77.77% cases. Conclusion: We conclude that there was male predominance and they were more affected in 2nd and 3rd decade. The lateral side of lower labial mucosa was the commonest site and the trauma due to teeth or lip biting was the major etiological factor for the occurrence of the mucocele. The article highlights role of psychological stress in occurrence of mucocele. The reader should understand the importance of histopathology examination and should try to control the psychological stress in such mucocele patients.

  4. Supply Chain Strategy: Empirical Case Study in Europe and Asia

    OpenAIRE

    Ilkka Sillanpää; Sebastian Sillanpää

    2014-01-01

    The purpose of this case study research is to present a literature review of supply chain strategy approaches, develop supply chain strategy framework and to validate a framework in empirical case study. Literature review and case study research are the research methods for this research. This study presents the supply chain strategy framework which merges together business environment, corporate strategy, supply chain demand and supply chain strategy. Research argues that all the different c...

  5. Isquemia do nervo óptico após intervenção cirúrgica na coluna vertebral: relato de caso Isquemia del nervio óptico después de la intervención quirúrgica en la columna vertebral: relato de caso Optic nerve ischemia after spine surgery: case report

    Directory of Open Access Journals (Sweden)

    Clóvis Marcelo Corso

    2006-06-01

    ía de columna vertebral en posición prona. RELATO DEL CASO: Paciente del sexo masculino, 58 años, índice de masa corporal de 37,6, con operación propuesta de descompresión medular asociada a la artrodesis de columna lumbar. Historial de tabaquismo e hipertensión arterial sin tratamiento. Exámenes físicos, de laboratorio y cardiológicos normales. La técnica anestésica utilizada fue la asociación de anestesia general con catéter peridural. No hubo ninguna complicación en el intraoperatorio. Al día siguiente, presentó proptosis ocular, edema conjuntival y pérdida visual en el ojo izquierdo. CONCLUSIONES: El caso evidencia la posibilidad de la pérdida visual después de la intervención quirúrgica de columna con el paciente en posición prona. La neuropatía óptica isquémica es el resultado del desequilibrio entre la oferta y la demanda de oxígeno en el nervio óptico a causa del aumento de la presión intra ocular (PIO con relación a la presión arterial sistémica, determinando la mala perfusión del tejido nervioso. Aunque todavía no esté clara la causa de esa complicación, pueden tenerse en cuenta como factores de riesgo, la avanzada edad, arteriosclerosis, diabetes melito, hipertensión arterial, tabaquismo, alteraciones en el suministro vascular y la duración del procedimiento.BACKGROUND AND OBJECTIVES: Visual loss is an uncommon complication in the postoperative period of non-ocular procedures and its incidence may be confirmed by the increasing number of studies in the international literature. This report aimed at describing a case of anopsia after prone spinal procedure. CASE REPORT: Male patient, 58 years old, body mass index of 37.6 scheduled for spinal cord decompression associated to lumbar spine arthrodesis. Clinical history of smoking and untreated hypertension. Normal physical, lab and cardiologic exams. Patient was anesthetized with general anesthesia associated to epidural catheter. There were no intraoperative complications

  6. Using Online Case Studies to Enhance Teacher Preparation

    Science.gov (United States)

    Richman, Laila

    2015-01-01

    The purpose of this study was to assess the impact interactive, online case studies have on learning for preservice teachers. More specifically, it evaluated whether the use of online case studies in instruction could enhance the level of knowledge the preservice teacher gained from the content material. This study utilized a nonequivalent group,…

  7. 2000 Johnston Site 3A-P

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 3A-P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on July 3, 2000. With a start point (meter 0) at...

  8. 2000 Johnston Site 1A-P

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 1A-P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on June 29, 2000. With a start point (meter 0) at...

  9. 2000 Johnston Site 2A-P

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 2A-P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on June 30, 2000. With a start point (meter 0) at...

  10. 2006 Johnston Site 1A-P

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Underwater Site 1A-P was established at Johnston Atoll by Dr. James Maragos, U.S. Fish & Wildlife Service, on June 29, 2000. With a start point (meter 0) at...

  11. Barron's AP English literature and composition

    CERN Document Server

    Ehrenhaft EdD, George

    2016-01-01

    Includes five full-length practice AP exams with all questions answered and explained. Also features additional reviews on poetry, fiction, and drama, definitions of 175 literary and rhetorical terms, and more. Can be purchased alone or with an optional CD-ROM with two additional practice tests.

  12. Two Successful Approaches to Teaching AP Government

    Science.gov (United States)

    Ladd, Brian; Stepp, Heidi

    2013-01-01

    Amador Valley High School, in Pleasanton, California, uses two unique approaches to teaching Advanced Placement Government and Politics. AP Government consists of six units: Constitutional Underpinnings; Political Behavior and Political Beliefs; Mass Media, Interest Groups, and Political Parties; Institutions of Government; Civil Liberties and…

  13. Trajetória institucional de um instituto público de pesquisa: o caso do Ital após 1995 Institutional trajectory of a public research institute: the case of Ital after 1995

    Directory of Open Access Journals (Sweden)

    Ana Elisa Brito Garcia

    2009-06-01

    Full Text Available Este artigo analisa a evolução organizacional de um instituto público de pesquisa tecnológica, o Instituto de Tecnologia de Alimentos (Ital por meio de um estudo de caso, num período de 10 anos. Aplica pela primeira vez os conceitos de modelos institucional e gerencial. Por modelo institucional entende-se a evolução das características jurídicas que permitem a uma instituição o cumprimento de suas funções sociais. O modelo gerencial compreende dois componentes: o compulsório e o estratégico. O primeiro trata da gestão dos processos decorrentes do modelo institucional, e o segundo, daqueles que são frutos de suas decisões estratégicas. A principal característica do Ital é ser uma instituição híbrida, pois juridicamente é um instituto público de pesquisa, mas gerenciado, em alguns aspectos, como uma empresa privada altamente inovadora. Na sua trajetória institucional, o Ital adotou uma organização descentralizada, o que lhe permitiu aprofundar os laços com o setor produtivo e aumentar a participação das fontes extraorçamentárias no seu orçamento total. O componente estratégico de seu modelo gerencial teve um peso muito grande nesse desenvolvimento. No entanto, seu modelo organizacional começa a apresentar sinais de esgotamento, colocando desafios para a sua continuidade como instituição de referência.This article analyzes the organizational development of a public research institute, the Food Technology Institute (Ital, during a period of 10 years. It applies the case study methodology and, for the first time, the concepts of institutional and managerial models. The first concept emphasizes the evolution of the formal characteristics which allow any institution to carry out its social functions. On the other hand, the managerial model consists of two components, the mandatory one, which results from the institutional model, and the strategic one, which results from the methods developed to organize and to

  14. Delusional parasitosis--study of 3 cases.

    Directory of Open Access Journals (Sweden)

    Hanumantha K

    1994-10-01

    Full Text Available Delusional disorder-somatic (parasitosis type is a rare psychiatric disorder which poses a challenge to diagnostic and therapeutic skills. Pimozide, a highly specific dopamine blocker has shown promising results in the 3 cases illustrated here. These cases were seen over a period of 3 years. All the three patients believed that an insect has entered through the ear and is burrowing tracts/laying multiple eggs. They approached the ENT surgeons or neurosurgeon with a fear that their brain will be invaded. On psychiatric evaluation, no past or present history of major psychiatric illness was found. Premorbid personalities were well adjusted. Only for two patients, acute moderate stressors were detected. Delusions disappeared by the end of 2 wks but therapy was continued for 5 months.

  15. Case study the poultry industry in Colombia

    OpenAIRE

    2003-01-01

    "As developing countries open their economies further to trade, their food industries are striving to raise safety and quality standards in order to compete in new markets. Such is the case with the Colombian poultry industry... Critical questions face the Colombian poultry industry: Is it ready to compete with foreign poultry producers on price, quality, and safety? Can industry efforts to produce better quality products assure an increased share of domestic and regional markets? This brief ...

  16. Orbital dermoid and epidermoid cysts: Case study

    Directory of Open Access Journals (Sweden)

    Veselinović Dragan

    2010-01-01

    Full Text Available Introduction. Dermoid and epidermoid cysts of the orbit belong to choristomas, tumours that originate from the aberrant primordial tissue. Clinically, they manifest as cystic movable formations mostly localized in the upper temporal quadrant of the orbit. They are described as both superficial and deep formations with most frequently slow intermittent growth. Apart from aesthetic effects, during their growth, dermoid and epidermoid cysts can cause disturbances in the eye motility, and in rare cases, also an optical nerve compression syndrome. Case Outline. In this paper, we described a child with a congenital orbital dermoid cyst localized in the upper-nasal quadrant that was showing signs of a gradual enlargement and progression. The computerized tomography revealed a cyst of 1.5-2.0 cm in size. At the Maxillofacial Surgery Hospital in Niš, the dermoid cyst was extirpated in toto after orbitotomy performed by superciliary approach. Postoperative course was uneventful, without inflammation signs, and after two weeks excellent functional and aesthetic effects were achieved. Conclusion. Before the decision to treat the dermoid and epidermoid cysts operatively, a detailed diagnostic procedure was necessary to be done in order to locate the cyst precisely and determine its size and possible propagation into the surrounding periorbital structures. Apart from cosmetic indications, operative procedures are recommended in the case of cysts with constant progressions, which cause the pressure to the eye lobe, lead to motility disturbances and indirectly compress the optical nerve and branches of the cranial nerves III, IV and VI.

  17. Insider Threat Case Studies at Radiological and Nuclear Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Pope, Noah Gale [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Hobbs, Christopher [Centre for Science and Security Studies, London (United Kingdom)

    2015-04-13

    Seven case studies are presented. The cases include thefts of various materials and sabotage. For each case there is an overview of the incident, a timeline, a profile of the perpetrator, and a discussion of the security system failures which allowed the incident to take place.

  18. Television Medical Dramas as Case Studies in Biochemistry

    Science.gov (United States)

    Millard, Julie T.

    2009-01-01

    Several case studies from popular television medical dramas are described for use in an undergraduate biochemistry course. These cases, which illustrate fundamental principles of biochemistry, are used as the basis for problems that can be discussed further in small groups. Medical cases provide an interesting context for biochemistry with video…

  19. Identification of Ambiguity in the Case Study Research Typology

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2015-01-01

    The purpose of this four volume collection is to provide an accessible selection of the best writing on case study in the English language internationally. Such a collection is timely and highly relevant to students, researchers and academics in higher education, especially when the case...... illustrations being adopted in the collection would provide comparative perspectives and international insights to scholars who are interested in English language studies in Asia." This collection takes a dutifully contemporary approach to the exploration of the uses and interpretations of the case study across....... Relevant to varied levels and scales of case study use, the aim of this collection is to provide readers with a comprehensive overview of where we are now with case study research, so that they may better judge their own applications of the case study. From definitions to interdisciplinary methods...

  20. The Use of Qualitative Content Analysis in Case Study Research

    OpenAIRE

    Florian Kohlbacher

    2006-01-01

    This paper aims at exploring and discussing the possibilities of applying qualitative content analysis as a (text) interpretation method in case study research. First, case study research as a research strategy within qualitative social research is briefly presented. Then, a basic introduction to (qualitative) content analysis as an interpretation method for qualitative interviews and other data material is given. Finally the use of qualitative content analysis for developing case studies is ...

  1. Síndrome compartimental em perna após reconstrução de ligamento cruzado anterior: relato de caso Leg's compartment syndrome after reconstruction of the anterior cruciate ligament: case report

    Directory of Open Access Journals (Sweden)

    Jorge Sayum Filho

    2011-01-01

    Full Text Available Os autores apresentam o relato de caso de um paciente que foi submetido à cirurgia de reconstrução de ligamento cruzado anterior e reparo de ligamento colateral medial de joelho esquerdo e que evoluiu com síndrome de compartimento de perna.The authors report a case of a patient that was submitted to a surgery of reconstruction of anterior cruciate ligament and collateral medial ligament repair of the left knee that complicated to a compartment syndrome.

  2. A Framework for Analysis of Case Studies of Reading Lessons

    Science.gov (United States)

    Carlisle, Joanne F.; Kelcey, Ben; Rosaen, Cheryl; Phelps, Geoffrey; Vereb, Anita

    2013-01-01

    This paper focuses on the development and study of a framework to provide direction and guidance for practicing teachers in using a web-based case studies program for professional development in early reading; the program is called Case Studies Reading Lessons (CSRL). The framework directs and guides teachers' analysis of reading instruction by…

  3. Use of Case Studies for Stimulating Thinking and Learning.

    Science.gov (United States)

    Zeakes, Samuel J.

    Noting that a case-study approach can stimulate student thinking and learning, this paper describes how students in a writing-intensive course on parasitology wrote brief medical case studies of parasites already studied for other students to read, evaluate, and identify the parasite. The paper presents a brief description of the course, an…

  4. A Mixed Methods Sampling Methodology for a Multisite Case Study

    Science.gov (United States)

    Sharp, Julia L.; Mobley, Catherine; Hammond, Cathy; Withington, Cairen; Drew, Sam; Stringfield, Sam; Stipanovic, Natalie

    2012-01-01

    The flexibility of mixed methods research strategies makes such approaches especially suitable for multisite case studies. Yet the utilization of mixed methods to select sites for these studies is rarely reported. The authors describe their pragmatic mixed methods approach to select a sample for their multisite mixed methods case study of a…

  5. Pityriasis amiantacea: a study of seven cases*

    Science.gov (United States)

    Amorim, Gustavo Moreira; Fernandes, Nurimar Conceição

    2016-01-01

    Pityriasis amiantacea was first described in 1832. The disease may be secondary to any skin condition that primarily affects the scalp, including seborrheic dermatitis. Its pathogenesis remains uncertain. We aim to analyze the epidemiological and clinical profiles of patients with pityriasis amiantacea to better understand treatment responses. We identified seven cases of pityriasis amiantacea and a female predominance in a sample of 63 pediatric patients with seborrheic dermatitis followed for an average of 20.4 months. We reported a mean age of 5.9 years. Five patients were female, with a mean age of 9 years. All patients were successfully treated with topic ketoconazole. PMID:27828657

  6. Pilonidal sinus (Nadi vrana): A case study

    OpenAIRE

    2010-01-01

    Pilonidal sinus (PNS) occurs in the cleavage between the buttocks (natal cleft) and can cause discomfort, embarrassment and absence from work for thousands of young people (mostly men) annually. The incidence of the disease is calculated to be 26 per 100,000 people. It occurs 2.2 times more often in men than in women. Age at presentation is 21 years for men and 19 years for women this case report describes a 22-year-old man with pilonidal sinus who was treated with ksharasutra.

  7. Pilonidal sinus (Nadi vrana): A case study.

    Science.gov (United States)

    Shinde, Pradeep; Toshikhane, Hemant

    2010-07-01

    Pilonidal sinus (PNS) occurs in the cleavage between the buttocks (natal cleft) and can cause discomfort, embarrassment and absence from work for thousands of young people (mostly men) annually. The incidence of the disease is calculated to be 26 per 100,000 people. It occurs 2.2 times more often in men than in women. Age at presentation is 21 years for men and 19 years for women this case report describes a 22-year-old man with pilonidal sinus who was treated with ksharasutra.

  8. Understanding energy poverty - Case study: Tajikistan

    Energy Technology Data Exchange (ETDEWEB)

    Robic, Slavica; Olshanskaya, Marina; Vrbensky, Rastislav; Morvaj, Zoran

    2010-09-15

    Access and affordability to energy services determine the state of energy poverty; however, there is no widely applicable definition of energy poverty and no universal set of measures for its eradication exists. This paper offers a new definition and possible solution for decrease, and eventually eradication, of energy poverty for the specific case of Tajikistan. As eradication of energy poverty needs to go in hand with nature preservation and economic development, authors provide possible approach to decrease of energy poverty in Tajikistan while simultaneously preserving nature and boosting the local economy.

  9. Management of neglected cervical spine dislocation: a study of six cases

    Directory of Open Access Journals (Sweden)

    Goni Vijay

    2013-08-01

    Full Text Available 【Abstract】Objective: To report a case series of six neglected cervical spine dislocations without neurological deficit, which were managed operatively. Methods: The study was conducted from August 2010 to December 2011 and cases were selected from the out-patient department of Postgraduate Institute of Medical Education and Research, India. The patients were in the age group of 30 to 50 years. All patients were operated via both anterior and posterior approaches. Results: During the immediate postoperative period, five (83.33% patients had normal neurological status. One (16.67% patient who had C 5 -C 6 subluxation developed neu-rological deficit with sensory loss below C 6 level and motor power of 2/5 in the lower limb and 3/5 in the upper limb below C 6 level. Conclusion: There is no role of skull traction in ne-glected distractive flexion injuries to cervical spine delayed for more than 3 weeks. Posterior followed by anterior ap-proach saves much time. If both approaches are to be done in the same sitting, there is no need for instrumentation posteriorly. But if staged procedure is planed, posterior sta-bilization is recommended, as there is a risk of deterioration in neurological status. Key words: Cervical vertebrae; Neck; Postoperative complications

  10. Evolution and protein interactions of AP2 proteins in Brassicaceae:Evidence linking development and environmental responses

    Institute of Scientific and Technical Information of China (English)

    Liping Zeng; Yue Yin; Chenjiang You; Qianli Pan; Duo Xu; Taijie Jin; Bailong Zhang; and Hong Ma

    2016-01-01

    Plants have evolved a large number of transcrip-tion factors (TF), which are enriched among duplicate genes, highlighting their roles in complex regulatory networks. The APETALA2/EREBP-like genes constitute a large plant TF family and participate in development and stress responses. To probe the conservation and divergence of AP2/EREBP genes, we analyzed the duplication patterns of this family in Brassicaceae and identified interacting proteins of represen-tative Arabidopsis AP2/EREBP proteins. We found that many AP2/EREBP duplicates generated early in Brassicaceae history were quickly lost, but many others were retained in all tested Brassicaceae species, suggesting early functional divergence followed by persistent conservation. In addition, the sequences of the AP2 domain and exon numbers were highly conserved in rosids. Furthermore, we used 16 A. thaliana AP2/EREBP proteins as baits in yeast screens and identified 1,970 potential AP2/EREBP-interacting proteins, with a small subset of interactions verified in planta. Many AP2 genes also exhibit reduced expression in an anther- defective mutant, providing a possible link to developmental regulation. The putative AP2-interacting proteins participate in many functions in development and stress responses, including photomorphogenesis, flower development, path-ogenesis, drought and cold responses, abscisic acid and auxin signaling. Our results present the AP2/EREBP evolution patterns in Brassicaceae, and support a proposed interaction network of AP2/EREBP proteins and their putative interacting proteins for further study.

  11. AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning

    Institute of Scientific and Technical Information of China (English)

    Yunbo Qiao; Yue Zhu; Nengyin Sheng; Jun Chen; Ran Tao; Qingqing Zhu; Ting Zhang; Cheng Qian; Naihe Jing

    2012-01-01

    Bone morphogenetic protein (BMP) inhibits neural specification and induces epidermal differentiation during ectodermal patterning.However,the mechanism of this process is not well understood.Here we show that AP2γ,a transcription factor activator protein (AP)-2 family member,is upregulated by BMP4 during neural differentiation of pluripotent stem cells.Knockdown of AP2γ facilitates mouse embryonic stem cell (ESC) neural fate determination and impairs epidermal differentiation,whereas AP2γ overexpression inhibits neural conversion and promotes epidermal commitment.In the early chick embryo,AP2γ is expressed in the entire epiblast before HH stage 3 and gradually shifts to the putative epidermal ectoderm during HH stage 4.In the future neural plate AP2γ inhibits excessive neural expansion and it also promotes epidermal development in the surface ectoderm.Moreover,AP2γ knockdown in ESCs and chick embryos partially rescued the neural inhibition and epidermal induction effects of BMP4.Mechanistic studies showed that BMP4 directly regulates AP2γ expression through Smad1 binding to the AP2γ promoter.Taken together,we propose that during the early stages of ectodermal patterning in the chick embryo,AP2γ acts downstream of the BMP pathway to restrict precocious neural expansion in the prospective neural plate and initiates epidermal differentiation in the future epidermal ectoderm.

  12. [Severe acute liver failure: a case study].

    Science.gov (United States)

    Moreno Arroyo, M Carmen; Puig Llobet, Montserrat; Cuervo Lavado, Luis

    2012-01-01

    Fulminant hepatic failure (FHF), also known as fulminant hepatitis, is a rare and extremely serious condition with a high mortality rate. Its rapid evolution and complexity in managing the treatment, creates the need to provide some immediate care by a team that specialises in intensive care. This acute decompensation is usually associated with other disorders, such as coagulopathy and hepatic encephalopathy, being responsible for major complications that can lead to organ failure. In our region the most common origin is unknown, followed by acute infection with hepatitis B. The treatment of this syndrome is based on the general measures applicable to any critically ill patient: treat the cause and early detection of extrahepatic complications, urgent liver transplantation being one of the alternatives with a better prognosis. This article presents a case report describing the monitoring of an Irish woman of 20 years who was transferred from a hospital in Ibiza to a hospital in Barcelona, with a suspected diagnosis of FHF. Following the conceptual model of Virginia Henderson, the collaborative problems and nursing diagnoses are described, presenting a care plan according to NANDA (North American Nursing Association), NIC (Nursing Intervention Classification), NOC (Nursing Outcomes Classification). This case helps to establish an individualised care plan that provides guidance to nurse professionals in critical patient care by increasing the knowledge of FHF.

  13. Logistics Outsourcing: Lessons from Case Studies

    Directory of Open Access Journals (Sweden)

    Aldo Srabotic

    2012-06-01

    Full Text Available This paper investigates key success factors in logistics outsourcing. Amodel is used to illustrate outsourcing relationships and then appliedto three examples from the logistics sector. The model is presented asa tool which can help managers to minimize the chance of failure byexplicitly addressing key issues prior to the implementation of a partnership.In order to fully capture the complexity of the outsourcingprocess, the model is refined by the analysis of implementation of outsourcingmethodology and the analysis of the presence of outsourcingmyths in each case. We find that the implementation of outsourcingmethodology is critical to successful outsourcing. Overall, we find thatthe main common factors leading to logistics outsourcing success, afterthe right third party service provider has been selected, are improvedservice levels and commercial viability for both parties, joint vision andobjectives of the partnership, clear roles, top management commitmentand support, communication and trust. The results of the case analysisshed light on what is the key to a successful outsourcing relationshipand indicate how the architecture of logistics outsourcing can be analyzedand improved.

  14. STUDY OF SIGNIFICANCE OF PLATELET COUNT IN FEVER CASES

    Directory of Open Access Journals (Sweden)

    Vasavilatha

    2015-01-01

    Full Text Available AIM: To study the significance of platelet count in various fevers and also identify the common causes of fever with thrombocytopenia . MATERIALS AND METHODS: 69 patients who were admitted with fever over 2 months of period from 15th October to15th December 2014 in King George Hospital AMC Visakhapatnam studied retrospectively. RESULTS: INCIDENCE: More than half of the cases (52.2% admitted with fever have thrombocytopenia. SEX: The study reveals that irrespective of sex and size of the sample the presentation of fever with/ without thromb ocytopenia could not found any significant difference . Degree of thrombocytopenia in various etiologies: in the present study it is found that out of 15 cases of falciparum malaria 10 cases had thrombocytopenia. Out of 12 undiagnosed cases 8 cases had thro mbocytopenia. Out of 4 cases of gastro intestinal system 3 cases had thrombocytopenia. In the present study it is significantly found that the highest difference is noticed in the presentation of dengue cases. Out of total sample (69 cases it is found tha t 5cases (7.2% of thrombocytopenia with dengue fever were found against 1case (1.4% of dengue fever with normal plate let count. The present study reveals that there is significant difference among various diseases such as malaria 14 (16.6%, dengue feve r 5 (13.9%, Urinary tract infection 2 (5.6%, undiagnosed cases 8 (22.2%. However severe thrombocytopenia (platelets less than 50,000 is seen in14 cases (38.8%out of 36 cases of fever with thrombocytopenia. Further this study reveals that in the cases of malaria 50% of cases reported as severe thrombocytopenia 7cases (19.4% followed by dengue fever3 cases (8.3%. CONCLUSION: Not only malaria, dengue fever and urinary tract infection can also cause severe thrombocytopenia. Fever cases especially with th rombocytopenia show seasonal variations, they are seen commonly in early winter. Febrile thrombocytopenia still presents as atypical and occult forms making

  15. TinyCoAP: A Novel Constrained Application Protocol (CoAP Implementation for Embedding RESTful Web Services in Wireless Sensor Networks Based on TinyOS

    Directory of Open Access Journals (Sweden)

    Anna Calveras

    2013-05-01

    Full Text Available In this paper we present the design and implementation of the Constrained Application Protocol (CoAP for TinyOS, which we refer to as TinyCoAP. CoAP seeks to apply the same application transfer paradigm and basic features of HTTP to constrained networks, while maintaining a simple design and low overhead. The design constraints of Wireless Sensor Networks (WSNs require special attention in the design process of the CoAP implementation. We argue that better performance and minimal resource consumption can be achieved developing a native library for the operating system embedded in the network. TinyOS already includes in its distribution an implementation of CoAP called CoapBlip. However, this is based on a library not originally designed to meet the requirements of TinyOS. We demonstrate the effectiveness of our approach by a comprehensive performance evaluation. In particular, we test and evaluate TinyCoAP and CoapBlip in a real scenario, as well as solutions based on HTTP. The evaluation is performed in terms of latency, memory occupation, and energy consumption. Furthermore, we evaluate the reliability of each solution by measuring the goodput obtained in a channel affected by Rayleigh fading. We also include a study on the effects that high workloads have on a server.

  16. In situ gel-forming AP-57 peptide delivery system for cutaneous wound healing.

    Science.gov (United States)

    Li, Xiaoling; Fan, Rangrang; Tong, Aiping; Yang, Meijia; Deng, Jiaojiao; Zhou, Liangxue; Zhang, Xiaoning; Guo, Gang

    2015-11-10

    In situ gel-forming system as local drug delivery system in dermal traumas has generated a great interest. Accumulating evidence shows that antimicrobial peptides play pivotal roles in the process of wound healing. Here in this study, to explore the potential application of antimicrobial peptide in wound healing, biodegradable poly(L-lactic acid)-Pluronic L35-poly(L-lactic acid) (PLLA-L35-PLLA) was developed at first. Then based on this polymer, an injectable in situ gel-forming system composed of human antimicrobial peptides 57 (AP-57) loaded nanoparticles and thermosensitive hydrogel was prepared and applied for cutaneous wound healing. AP-57 peptides were enclosed with biocompatible nanoparticles (AP-57-NPs) with high drug loading and encapsulation efficiency. AP-57-NPs were further encapsulated in a thermosensitive hydrogel (AP-57-NPs-H) to facilitate its application in cutaneous wound repair. As a result, AP-57-NPs-H released AP-57 in an extended period and exhibited quite low cytotoxicity and high anti-oxidant activity in vitro. Moreover, AP-57-NPs-H was free-flowing liquid at room temperature, and can form non-flowing gel without any crosslink agent upon applied on the wounds. In vivo wound healing assay using full-thickness dermal defect model of SD rats indicated that AP-57-NPs-H could significantly promote wound healing. At day 14 after operation, AP-57-NPs-H treated group showed nearly complete wound closure of 96.78 ± 3.12%, whereas NS, NPs-H and AP-57-NPs group recovered by about 68.78 ± 4.93%, 81.96 ± 3.26% and 87.80 ± 4.62%, respectively. Histopathological examination suggested that AP-57-NPs-H could promote cutaneous wound healing through enhancing granulation tissue formation, increasing collagen deposition and promoting angiogenesis in the wound tissue. Therefore, AP-57-NPs-H might have potential application in wound healing.

  17. Knockdown of CDK2AP1 in primary human fibroblasts induces p53 dependent senescence.

    Directory of Open Access Journals (Sweden)

    Khaled N Alsayegh

    Full Text Available Cyclin Dependent Kinase-2 Associated Protein-1 (CDK2AP1 is known to be a tumor suppressor that plays a role in cell cycle regulation by sequestering monomeric CDK2, and targeting it for proteolysis. A reduction of CDK2AP1 expression is considered to be a negative prognostic indicator in patients with oral squamous cell carcinoma and also associated with increased invasion in human gastric cancer tissue. CDK2AP1 overexpression was shown to inhibit growth, reduce invasion and increase apoptosis in prostate cancer cell lines. In this study, we investigated the effect of CDK2AP1 downregulation in primary human dermal fibroblasts. Using a short-hairpin RNA to reduce its expression, we found that knockdown of CDK2AP1 in primary human fibroblasts resulted in reduced proliferation and in the induction of senescence associated beta-galactosidase activity. CDK2AP1 knockdown also resulted in a significant reduction in the percentage of cells in the S phase and an accumulation of cells in the G1 phase of the cell cycle. Immunocytochemical analysis also revealed that the CDK2AP1 knockdown significantly increased the percentage of cells that exhibited γ-H2AX foci, which could indicate presence of DNA damage. CDK2AP1 knockdown also resulted in increased mRNA levels of p53, p21, BAX and PUMA and p53 protein levels. In primary human fibroblasts in which p53 and CDK2AP1 were simultaneously downregulated, there was: (a no increase in senescence associated beta-galactosidase activity, (b decrease in the number of cells in the G1-phase and increase in number of cells in the S-phase of the cell cycle, and (c decrease in the mRNA levels of p21, BAX and PUMA when compared with CDK2AP1 knockdown only fibroblasts. Taken together, this suggests that the observed phenotype is p53 dependent. We also observed a prominent increase in the levels of ARF protein in the CDK2AP1 knockdown cells, which suggests a possible role of ARF in p53 stabilization following CDK2AP1

  18. AE8/AP8 Implementations in AE9/AP9, IRBEM, and SPENVIS

    Science.gov (United States)

    2014-02-18

    period applies to orbit generation only; AE8/AP8 utilizes geomagnetic field models from other epochs as specified in the table below.) SHIELDOSE2 model...Cain, J. C., S. J. Hendricks, R. A. Langel, and W. V. Hudson (1967), A proposed model for the international geomagnetic reference field, 1965, J...trapped particle fluxes with the NASA models AP-8 and AE-8, Radiat. Meas., 26, pp. 947-952. International Association of Geomagnetism and Aeronomy

  19. Determination of Heats of Fusion: Using Differential Scanning Calorimetry for the AP Chemistry Courses.

    Science.gov (United States)

    Temme, Susan M.

    1995-01-01

    Describes an exercise designed to be used in an Advanced Placement (AP) chemistry course to accompany the study of thermodynamics. Uses Differential Scanning Calorimetry in teaching the concepts of thermochemistry and thermodynamics. (JRH)

  20. A rare combination of type 3 autoimmune polyendocrine syndrome (APS-3) or multiple autoimmune syndrome (MAS-3)

    OpenAIRE

    Betterle, Corrado; Garelli, Silvia; Coco, Graziella; Burra, Patrizia

    2014-01-01

    Context Type 3 autoimmune polyendocrine syndrome (APS-3) is defined by the presence of an autoimmune thyroid disease and another autoimmune illness, excluding Addison’s disease; this is a frequent combination. Case presentation We report the case of a 55 years old female patient with APS-3, with seven clinical or latent autoimmune manifestations. At 49 years of age she was admitted at the General Hospital for leukopenia, weight loss, tremors, anxiety and diarrhea. The personal history reveale...

  1. Case Study: Let's Get Personal--Putting Personality into Your Cases

    Science.gov (United States)

    Herreid, Clyde Freeman

    2017-01-01

    In this case study, the subject for discussion is the need to use teaching notes in order to add personality to case studies. Personality, it is said, is more important than policy, than demographics, than finances, or amorous peccadillos. Personality is essential. It is the interaction of people that capture our interest, yet, the question is…

  2. Methodology Series Module 2: Case-control Studies.

    Science.gov (United States)

    Setia, Maninder Singh

    2016-01-01

    Case-Control study design is a type of observational study. In this design, participants are selected for the study based on their outcome status. Thus, some participants have the outcome of interest (referred to as cases), whereas others do not have the outcome of interest (referred to as controls). The investigator then assesses the exposure in both these groups. The investigator should define the cases as specifically as possible. Sometimes, definition of a disease may be based on multiple criteria; thus, all these points should be explicitly stated in case definition. An important aspect of selecting a control is that they should be from the same 'study base' as that of the cases. We can select controls from a variety of groups. Some of them are: General population; relatives or friends; and hospital patients. Matching is often used in case-control control studies to ensure that the cases and controls are similar in certain characteristics, and it is a useful technique to increase the efficiency of the study. Case-Control studies can usually be conducted relatively faster and are inexpensive - particularly when compared with cohort studies (prospective). It is useful to study rare outcomes and outcomes with long latent periods. This design is not very useful to study rare exposures. Furthermore, they may also be prone to certain biases - selection bias and recall bias.

  3. Benzocaine-induced methaemoglobinaemia: a case study.

    Science.gov (United States)

    Bittmann, Stefan; Krüger, Carsten

    Benzocaine is a widely used topical anaesthetic and has been reported to cause toxic methaemoglobinaemia in otherwise healthy individuals with no predisposing risk factors. This article reports on a rare case of benzocaine-induced methaemoglobinaemia following adenotonsillectomy in a 5-year-old girl. Topical benzocaine was applied orally for the relief of postoperative wound pain on the eighth postoperative day. Two hours after application, generalized cyanosis, mild dyspnoea and some degree of agitation developed. The methaemoglobin level was 38.5%. Treatment with methylene blue was initiated immediately. Symptoms completely disappeared 4 hours after initiation of methylene blue therapy. The further course was uneventful. Therefore, all health professionals should be aware that topical anaesthetics after surgery can induce methaemoglobinaemia in children, even after a prolonged interval, and especially when applied on wound surfaces.

  4. Heartworm disease: Case study in dog patient

    Directory of Open Access Journals (Sweden)

    Spasojević-Kosić Ljubica

    2011-01-01

    Full Text Available Dirofilaria immitis is a parasite in a. pulmonalis in domestic and wild carnivora. Partial development and the transfer of this parasite among carnivora takes place through the mosquito, which makes possible the maintaining and spreading of this parasite among populations of susceptible animals. Heartworm disease, which is caused by Dirofilaria immitis, is most often manifested as changes in the respiratory and cardiovascular systems. This paper presents the case of heartworm disease in a dog. The therapy used to treat this disease in the dog was a combination of doxycycline and ivermectin. The blood test results indicated a rapid decrease in the number of microfilaria and lowering of the antigen level of the adult parasite. The conducted general and special clinical examinations of the respiratory and cardiovascular systems registered an improvement in the clinical condition of the patient.

  5. Does Pregnancy-Associated Breast Cancer Imply a Worse Prognosis? A Matched Case-Case Study

    Science.gov (United States)

    Dimitrakakis, Constantine; Zagouri, Flora; Tsigginou, Alexandra; Marinopoulos, Spyros; Sergentanis, Theodoros N.; Keramopoulos, Antonis; Zografos, George C.; Ampela, Konstantina; Mpaltas, Dimosthenis; Papadimitriou, Christos; Dimopoulos, Meletios-Athanassios; Antsaklis, Aris

    2013-01-01

    Summary Background Significant controversy exists in the literature regarding the role of pregnancy in the prognosis of breast cancer. We designed a matched case-case study, matching pregnancy-associated breast cancer (PABC) cases with breast cancer cases for stage, age, and year of diagnosis. Patients and Methods 39 consecutive cases of PABC were matched with 39 premenopausal cases of breast cancer. Univariate and multivariate survival analyses followed by adjustment for stage, grade, estrogen receptor status, and age at diagnosis, were performed. Results Regarding overall survival (OS), univariate analysis pointed to longer OS in non-PABC cases vs. PABC cases. Accordingly, a more advanced stage predicted shorter survival. In the multivariate analysis, the independent aggravating effect mediated by pregnancy persisted. Interestingly, a post hoc nested analysis within PABC cases indicated that the 3rd trimester pointed to shorter OS. The aforementioned results on OS were also replicated during the examination of relapse-free survival. Conclusion Implementing a matched case-case design, the present study points to pregnancy as a poor prognostic factor for breast cancer. PMID:24415971

  6. Environmental reference materials methods and case studies

    DEFF Research Database (Denmark)

    Schramm-Nielsen, Karina Edith

    1998-01-01

    be modelled when the length of the study is unknown. Experimental data has been collected from two stability studies of aqueous matrices. The first study regards the stability of TN NO² + ³-N and n in autoclaved wastewater samples over a period of 22 months. Data was collected specifically for this study....... The methods have been evaluated with regard to their robustness towards variations in the chemical analytical method and with regard to the number of times a significant out of control situation is indicated. The second study regards the stability of NH4-N and total phosphorous in autoclaved seawater samples...

  7. On the structure of AP-4 responsive element in the LTR of Jembrana disease virus

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Previous studies with deletion and sequence analysis of JDV LTR showed that there is a putative AP-4 responsive element in LTR. By antisense transient assay and gel shifting assay, we for the first time demonstrated that AP-4 modulated JDV gene expression by binding DNA directly to bovine cells. The results, derived from site-directed mutagenesis experiments, suggest that the six base pairs of AP-4 binding site (CAGCTG) have different effects on JDV gene expression. When the first two base pairs changed to GC, JDV gene expression is severely decreased.

  8. Deep stromal mycobacterial keratitis: viable bacteria after six months of treatment: case report and literature review Ceratite estromal profunda por micobactéria: bactéria viável após seis meses de tratamento: relato de caso e revisão da literatura

    Directory of Open Access Journals (Sweden)

    Filipe Accioly de Gusmão

    2005-08-01

    Full Text Available To report the presence of viable mycobacteria in a patient with keratitis treated for 6 months. Species identification was performed using the PRA method (polymerase chain reaction followed by restriction endonuclease analysis. Clonality was evaluated with RAPD (randomly amplified polymorphic DNA and ERIC-PCR (enterobacterial repetitive intergenic consensus - polymerase chain reaction methods. The patient reported trauma due to a metallic foreign body 3 weeks prior to presentation. Initial corneal scraping cultures revealed Mycobacterium abscessus. After 6 months of topical and systemic treatment the patient presented with no active inflammation and was considered clinically cured. An optic penetrating keratoplasty was performed. Culture of the excised cornea revealed Mycobacterium abscessus. Both isolates had the same clonal origin. The most interesting finding of this case report was the positive culture of the excised cornea after 6 months of intensive specific topical therapy. To our knowledge, this is the first report in the literature showing this possibility in the treatment of Mycobacterial keratitis. Thus, Mycobacterium abscessus may present viable bacteria after long-term treatment and should be followed carefully for a long period of time after tapering the medication.O objetivo do caso é descrever a presença de micobactérias viáveis em pacientes com ceratite, 6 meses após tratamento intensivo. A identificação de espécies, foi efetuada usando método PRA (polymerase chain reaction seguida pela restriction endonuclease analysis. Clonalidade foi avaliada pelos métodos RAPD (randomly amplified polymorphic DNA e ERIC-PCR (enterobacterial repetitive intergenic consensus - polymerase chain reaction. Paciente refere trauma com corpo estranho metálico há 3 semanas. A cultura da córnea revelou Mycobacterium abscessus. Após 6 meses de tratamento tópico e sistêmico, paciente apresentava-se sem inflamação, sendo considerado

  9. Remission of refractory chronic cluster headache after warfarin administrations: case report Remissão de cefaléia em salvas crônica refratária após administração de varfarina: relato de caso

    Directory of Open Access Journals (Sweden)

    Jano Alves de Souza

    2004-12-01

    Full Text Available Isolated reports of a possible positive effect of anti-coagulant drugs, among them heparin, warfarin and acenocumarol, in migraine prophylaxis are found in the literature. We report the case of a 37 years old man suffering from refractory chronic cluster headache that presented remission with the administration of warfarin for the treatment of deep venous thrombosis associated to arterial thrombosis. We did not found any case like that in the literature.Alguns relatos isolados na literatura referem-se a um possível efeito profilático de drogas anticoagulantes, entre elas a heparina, varfarina e acenocumarol na profilaxia da migrânea. Apresentamos o caso de um homem de 37 anos com cefaléia em salvas crônica refratária que obteve remissão total das crises após a administração de varfarina para o tratamento de trombose venosa e arterial. Não encontramos nenhum relato semelhante na literatura consultada.

  10. Hemorragia de tronco cerebral após remoção cirúrgica de cisto aracnóide da fissura silviana: Relato de caso Brainstem hemorrhage after surgical removal of arachnoid cyst of the sylvian fissure: case report

    Directory of Open Access Journals (Sweden)

    Guilherme Borges

    1995-12-01

    Full Text Available Os autores relatam um caso de hemorragia de tronco cerebral após craniotomia para ressecção de grande cisto aracnóide de fissura silviana esquerda. A sintomatologia inicial pré-operatória incluía sinais de hipertensão intracraniana e a tomografia computadorizada mostrava desvio de linha média. Diversos fatores são discutidos para explicar o sangramento parenquimatoso pós-operatório: edema cerebral, diminuição do retorno venoso e de fluxo sanguíneo no lado comprimido. Entretanto a fisiopatologia da hemorragia parenquimatosa em casos como o relatado permanece obscura. Uma abordagem cirúrgica mais cautelosa é proposta nesses pacientes com de hipertensão intracraniana.The authors report a case of a hemorrhage of the brainstem after craniotomy for resection of a huge arachnoid cyst of the sylvian fissure on the left hemisphere. The previous simptomatology included clinical signs of increased intracranial pressure, and the computerized tomography showed midline shift. Some factors may contribute to brain hemorrhage post-operatively: cerebral edema, ipsilateral changes in the venous reflux and blood perfusion, although the physiopathology remains obscure. A more careful approach is suggested in such cases with intracranial hypertension.

  11. THE APPLICATION OF CASE STUDY IN ENGINEERING DRAWING COURSE

    OpenAIRE

    Zhang, Wenying; Yuan, Yuefeng

    2015-01-01

    The paper describes the case study in engineering drawing course in the process of assembly drawing by using customized software. The process is reflecting three steps of an engineering case solving: design, processing and installation. Using case study for design drawings students can master the main components of assembly drawing, understand assembly drawing and learn the AutoCAD software. All this can improve the quality of teaching.

  12. Effects of Microstructure and the Form and Size on Mechanical Properties of AP-CMDB Propellant at Low Temperature%AP-CMDB 推进剂微观结构及药形尺寸对低温力学性能的影响

    Institute of Scientific and Technical Information of China (English)

    张正中; 樊学忠; 李吉祯; 刘晓军; 党永战; 张亚俊

    2015-01-01

    To study the cause of producing cracking propellant in engine test at low temperature for AP-CMDB propellant prepared by solvent-extrusion method,the microstructure of the sample was observed by scanning electron microscopy and energy spectrometer.The linear expansion matching of AP particles and binder system was studied via measuring the linear expansion coefficient of AP-CMDB propellant.The effects of the form and size on the impact resistance of the propellant were studied.The results show that there are lots of micro-holes and a few micro-cracks in the propellant grain prepared by solvent-extrusion method,the agglomeration of AP particles is ob-vious,and the Al particles and binder system appear serious interface debonding.The linear expansion matching be-tween AP particles and binder system is poor.The impact resistance of single-tube propellant grain with wall thinckness of 1.5 mm is lower than that of propellant with wall thickness of 4.5 mm at -40℃.The impact resist-ance of propellant grain with casing structure is lower than that of propellant with single-tube structure.The forma-tion of cracking propellant at low temperature for AP-CMDB propellant correlates with the microstructure,mechani-cal property,form and size of the propellant.%为研究溶剂压伸法制备的 AP-CMDB 推进剂低温发动机试验易产生碎药的原因,采用扫描电子显微镜(SEM)和能谱仪(EDS)观察了 AP-CMDB 推进剂样品的微观结构;通过测试样品的线膨胀系数,研究了 AP 颗粒与黏合剂体系的线膨胀匹配性;讨论了药形尺寸对推进剂低温抗冲强度的影响。结果表明,溶剂压伸法制备的 AP-CMDB 推进剂药柱中存在大量微孔和少量微裂纹,AP 颗粒团聚明显,Al 颗粒与黏合剂体系间出现严重的界面脱粘;AP 颗粒与黏合剂体系间的线膨胀匹配性较差;壁厚1.5 mm 的单孔管状药柱的低温(-40℃)抗冲强度低于壁厚4.5 mm 的,套

  13. The Role of the Clathrin Adaptor AP-1: Polarized Sorting and Beyond

    Directory of Open Access Journals (Sweden)

    Fubito Nakatsu

    2014-11-01

    Full Text Available The selective transport of proteins or lipids by vesicular transport is a fundamental process supporting cellular physiology. The budding process involves cargo sorting and vesicle formation at the donor membrane and constitutes an important process in vesicular transport. This process is particularly important for the polarized sorting in epithelial cells, in which the cargo molecules need to be selectively sorted and transported to two distinct destinations, the apical or basolateral plasma membrane. Adaptor protein (AP-1, a member of the AP complex family, which includes the ubiquitously expressed AP-1A and the epithelium-specific AP-1B, regulates polarized sorting at the trans-Golgi network and/or at the recycling endosomes. A growing body of evidence, especially from studies using model organisms and animals, demonstrates that the AP-1-mediated polarized sorting supports the development and physiology of multi-cellular units as functional organs and tissues (e.g., cell fate determination, inflammation and gut immune homeostasis. Furthermore, a possible involvement of AP-1B in the pathogenesis of human diseases, such as Crohn’s disease and cancer, is now becoming evident. These data highlight the significant contribution of AP-1 complexes to the physiology of multicellular organisms, as master regulators of polarized sorting in epithelial cells.

  14. Two tobacco AP1-like gene promoters with highly specific, tightly regulated and uniquely expressed activity during floral transition, initiation and development

    Science.gov (United States)

    Biotech engineering of agronomic traits requires an array of highly specific and tightly regulated promoters in flower or other tissues. In this study, we isolated and characterized two tobacco AP1-like promoters (termed NtAP1La and NtAP1Lb1) in transgenic plants using GUS reporter and tissue-speci...

  15. Final report for tank 241-AP-108, grab samples 8AP-96-1, 8AP-96-2 and 8AP-96-FB

    Energy Technology Data Exchange (ETDEWEB)

    Esch, R.A.

    1996-04-19

    This document is the final report deliverable for the tank 241-AP-108 grab samples. The samples were subsampled and analyzed in accordance with the TSAP. Included in this report are the results for the Waste Compatibility analyses, with the exception of DSC and thermogravimetric analysis (TGA) results which were presented in the 45 Day report (Part 2 of this document). The raw data for all analyses, with the exception of DSC and TGA, are also included in this report.

  16. An Updated AP2 Beamline TURTLE Model

    Energy Technology Data Exchange (ETDEWEB)

    Gormley, M.; O' Day, S.

    1991-08-23

    This note describes a TURTLE model of the AP2 beamline. This model was created by D. Johnson and improved by J. Hangst. The authors of this note have made additional improvements which reflect recent element and magnet setting changes. The magnet characteristics measurements and survey data compiled to update the model will be presented. A printout of the actual TURTLE deck may be found in appendix A.

  17. Using DCAT-AP for research data

    OpenAIRE

    PEREGO ANDREA; FRIIS-CHRISTENSEN Anders; VACCARI LORENZINO; TSINARAKI CHRYSI

    2016-01-01

    This paper outlines a set cross-domain requirements for the documentation of scientific data, identified during the development of the corporate data catalogue of the European Commission's Joint Research Centre (JRC). In particular, we illustrate how we have extended the DCAT application profile for European data portals (DCAT-AP) to accomodate requirements for scientific datasets, and we discuss a number of issues still to be addressed.

  18. Cultural Diversity in AP Art History

    Science.gov (United States)

    Bolte, Frances R.

    2006-01-01

    Teaching AP Art History is like running on a treadmill that is moving faster than a teacher can run. Many teachers are out of breath before the end of the term and wonder how in the world they can cover every chapter. Because time is short and art from pre-history through to the present, including the non-European traditions, must be covered, this…

  19. Educational Cost Analysis in Action: Case Studies for Planners -- II.

    Science.gov (United States)

    Coombs, Philip H.; Hallak, Jacques

    This document is the second in a series of three documents, which together contain 27 case studies on the uses of cost analysis in educational planning. The case studies are presented to help planners and administrators see how cost analysis can be used to improve the efficiency of their educational systems, or to get the best value existing…

  20. Educational Cost Analysis in Action: Case Studies for Planners -- III.

    Science.gov (United States)

    Coombs, Philip H.; Hallak, Jacques

    This document is the third in a series of three documents, which together contain 27 case studies on the uses of cost analysis in educational planning. The case studies have been presented to help planners and administrators see how cost analysis can be used to improve the efficiency of their educational systems, and to get the best value from…

  1. Educational Cost Analysis in Action: Case Studies for Planners -- I.

    Science.gov (United States)

    Coombs, Philip H.; Hallak, Jacques

    This document is the first in a series of three documents, which together contains 27 case studies on the uses of cost analysis in educational planning. The case studies have been presented to help planners and administrators see how cost analysis can be used to improve the efficiency of their educational systems, or how to get the best value from…

  2. Using the Case Study Method in Teaching College Physics

    Science.gov (United States)

    Burko, Lior M.

    2016-01-01

    The case study teaching method has a long history (starting at least with Socrates) and wide current use in business schools, medical schools, law schools, and a variety of other disciplines. However, relatively little use is made of it in the physical sciences, specifically in physics or astronomy. The case study method should be considered by…

  3. Case-crossover studies of occupational trauma: methodological caveats

    OpenAIRE

    Sorock, G; Lombardi, D; Gabel, C; Smith, G; Mittleman, M

    2001-01-01

    Objectives—The case-crossover study design was developed to examine triggers for the onset of myocardial infarction. This paper seeks to examine selected methodological issues when applying the case-crossover method to the study of traumatic injuries in the work environment.

  4. Hamlet's Suicide Soliloquy: A Case Study in Suicide Ideology.

    Science.gov (United States)

    Jenkins, Andrew P.

    This paper presents a secondary-level teaching technique that can be used in an integrated English and health education curriculum. The exercise provides students and teachers with a case study of a suicidal person for the purpose of teaching the warning signs of suicide, appropriate questioning, and referral skills. The case study uses Hamlet's…

  5. Using Clinical Gait Case Studies to Enhance Learning in Biomechanics

    Science.gov (United States)

    Chester, Victoria

    2011-01-01

    Clinical case studies facilitate the development of clinical reasoning strategies through knowledge and integration of the basic sciences. Case studies have been shown to be more effective in developing problem-solving abilities than the traditional lecture format. To enhance the learning experiences of students in biomechanics, clinical case…

  6. Hungarian Librarianship in Transition: An Academic Case Study.

    Science.gov (United States)

    Koltay, Zsuzsa; Parmer, Coleen

    This case study of the Kossuth Lajos Tudomanyeyetem, an academic library in Debrecen (Hungary), conducted in May 1992, describes its functioning and needs. Information gathered through a series of interviews, tours, library reports, and a review of relevant literature forms the basis for the case study. An overview of the library in its historical…

  7. A Case Study on Special Education in the Philippines.

    Science.gov (United States)

    Pascual, Dolores M.; Gregorio, Julieta A.

    This case study, undertaken as part of a Unesco survey of its member states, documents facilities and services for the education of disabled persons in the Philippines. The case study reports that Philippine children and youth with special needs are provided with access to educational opportunities that develop their potential and enable them to…

  8. Release and deployment at Planon: a case study

    NARCIS (Netherlands)

    Jansen, R.L.; Ballintijn, G.C.; Brinkkemper, S.

    2005-01-01

    This case study report describes the research results of a case study at Planon into the processes of development, release, and deployment. The research was done to document the release and deployment processes at Planon, to uncover strengths and weaknesses in these processes, and to compare Planon

  9. A Case Study in Elementary Statistics: The Florida Panther Population

    Science.gov (United States)

    Lazowski, Andrew; Stopper, Geffrey

    2013-01-01

    We describe a case study that was created to intertwine the fields of biology and mathematics. This project is given in an elementary probability and statistics course for non-math majors. Some goals of this case study include: to expose students to biology in a math course, to apply probability to real-life situations, and to display how far a…

  10. Case Study: Student-Produced Videos for the Flipped Classroom

    Science.gov (United States)

    Prud'homme-Genereux, Annie

    2016-01-01

    This column provides original articles on innovations in case study teaching, assessment of the method, as well as case studies with teaching notes. This month's issue describes a way of building a library of student-produced videos to use in the flipped classroom.

  11. Bridging the Performance Gap with Ergonomics: A Case Study

    Science.gov (United States)

    Rethaber, James D.

    2011-01-01

    Faced with increased incidences of work-related strain and sprain injuries and OSHA-recordable injuries, the organization in this case study details how it resolved these performance-related issues. This case study also demonstrates the effectiveness of Thomas Gilbert's (1978) Behavior Engineering Model as a tool for analyzing, defining, and…

  12. On misunderstandings in connection with case-studies

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    2005-01-01

    useful for generating hypotheses, while other methods aremore suitable for hypotheses testing and theory building; (4) The case study contains a bias toward verification; and (5) It is often difficult to summarize specific case studies. The article explains and corrects these misunderstandings one by one...

  13. Using a Case-Study Article to Effectively Introduce Mitosis

    Science.gov (United States)

    Van Hoewyk, Doug

    2007-01-01

    Community college students in a nonmajors biology class are introduced to mitosis by reading a case-study article that allows them to gauge how many times various parts of their bodies have been regenerated. The case-study article allows students to develop a conceptual framework of the cell cycle prior to a lecture on mitosis. (Contains 1 figure.)

  14. British Military Intervention into Sierra Leone: A Case Study

    Science.gov (United States)

    2007-12-14

    BRITISH MILITARY INTERVENTION INTO SIERRA LEONE : A CASE STUDY A thesis presented to the Faculty of the U.S. Army Command and...NUMBER 5b. GRANT NUMBER 4. TITLE AND SUBTITLE British Military Intervention into Sierra Leone : A Case Study 5c. PROGRAM ELEMENT NUMBER 5d...

  15. The Use of Business Case Studies in Business German Classes.

    Science.gov (United States)

    Schutte, Lilith

    The use of business case studies, defined as sophisticated models that present practical business problems and theoretical guidelines that can be used to solve the problems, is discussed. It is suggested that the main advantages of case studies are that they are usually more interesting to read than theoretical materials and they encourage student…

  16. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    Science.gov (United States)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  17. Architecture Analysis with AADL: The Speed Regulation Case-Study

    Science.gov (United States)

    2014-11-01

    inter-connected with two buses 25 Speed Regulation Case-Study Julien Delange © 2014 Carnegie Mellon University Architecture Alternative 1 50 MIPS 50 MIPS ...functions collocated on the same processor 26 Speed Regulation Case-Study Julien Delange © 2014 Carnegie Mellon University 50 MIPS 50 MIPS 50 MIPS Bandwidth

  18. A Neuroanatomy Teaching Activity Using Case Studies and Collaboration.

    Science.gov (United States)

    Sheldon, Jane P.

    2000-01-01

    Describes an activity for use in an introductory psychology course in which students collaborate and apply their neuroanatomy knowledge to three case studies. Provides a table with descriptions of and possible answers for the three case studies and discusses the students' responses. (CMK)

  19. Complexity, Representation and Practice: Case Study as Method and Methodology

    Science.gov (United States)

    Miles, Rebecca

    2015-01-01

    While case study is considered a common approach to examining specific and particular examples in research disciplines such as law, medicine and psychology, in the social sciences case study is often treated as a lesser, flawed or undemanding methodology which is less valid, reliable or theoretically rigorous than other methodologies. Building on…

  20. Evaluating Office Environments: A Case Study

    Science.gov (United States)

    1994-05-01

    The importance of a follow-up, post occupancy evaluation that challenges the redesigned product also is illustrated. The study shows the information...of Age, memo (Architecture Team, USACERL, February 13, 1992), pp 1-6. Weidemann, S., and J.R. Anderson, "Issues in the Analysis of Post - Occupancy Studies