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Sample records for aorta del conejo

  1. Evaluación del peso de conejos para carne alimentados con diferentes ensilajes

    OpenAIRE

    Rigoberto Villa-Ramírez; Jaime Hurtado-Villegas

    2016-01-01

    En la Granja Experimental Bengala, de la Universidad del Quindío, ubicada en el municipio de Filandia, Quindío, se evaluó la ganancia de peso en conejos tipo carne cuando son alimentados con diferentes ensilajes: pasto imperial (Axonopus scoparius), pasto imperial mezclado con botón de oro (Tithonia diversifolia (Hemsl.), pasto imperial con ramio (Boehmeria nivea) y pasto imperial con morera (Morus alba). Se valoraron cuatro tratamientos en cuatro grupos de cinco conejos cada uno. Los conejos...

  2. Toxicidad aguda oral del D-003 en conejos F1

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    Rafael Gámez

    2005-01-01

    acuerdo con ello y teniendo en cuenta que el conejo es una especie comúnmente utilizada para evaluar sustancias hipolipemiantes, se seleccionó esta especie para investigar la toxicidad por dosis orales únicas del D-003. De modo consistente con los resultados de los estudios agudos en roedores que revelaron que el D-003 no era tóxico por vía oral, en el presente estudio se administraron dosis únicas de 800, 2 000 y 5 000 mg/kg. Los animales se observaron durante 14 d, se controló el consumo de alimentos, se registró el peso corporal y los signos clínicos. Adicionalmente y dada la sensibilidad del conejo a las drogas hipolipemiantes, en los animales supervivientes se determinaron indicadores hematológicos y de bioquímica sanguínea. Además, durante la autopsia se realizó el estudio macroscópico de los órganos, se determinó el peso relativo de los órganos respecto al peso corporal, y se llevó a cabo el estudio histopatológico. Los resultados confirman que el D-003 administrado por vía oral a dosis únicas muy elevadas no resulta tóxico, lo cual se sustenta no solo en datos de mortalidad y síntomas, sino tambíen, en otros indicadores actualmente no exigidos en este tipo de estudio toxicológico.

  3. El peso del conejo de monte criado en jaula

    OpenAIRE

    P. González-Redondo

    1997-01-01

    Live weights of 19 wild rabbits (Orycrolagus cuniculus) reared in cages were measured and compared to the expected weights according to the growth curve followed by the wild rabbits growing in a natural environment. The results obtained, show that the rearing in captivity does not produces an increase in live weight of the wil rabbit. Los pesos de 19 conejos de monte (Orycrolagus cuniculus) criados en jaula fueron medidos y comparados con los pesos esperados segun una curva de crecimiento ...

  4. Evaluación del peso de conejos para carne alimentados con diferentes ensilajes

    Directory of Open Access Journals (Sweden)

    Rigoberto Villa-Ramírez

    2016-11-01

    Full Text Available En la Granja Experimental Bengala, de la Universidad del Quindío, ubicada en el municipio de Filandia, Quindío, se evaluó la ganancia de peso en conejos tipo carne cuando son alimentados con diferentes ensilajes: pasto imperial (Axonopus scoparius, pasto imperial mezclado con botón de oro (Tithonia diversifolia (Hemsl., pasto imperial con ramio (Boehmeria nivea y pasto imperial con morera (Morus alba. Se valoraron cuatro tratamientos en cuatro grupos de cinco conejos cada uno. Los conejos alimentados con ensilaje de pasto imperial y botón de oro fueron los que obtuvieron el mayor peso (2389 g, en promedio, mientras que los alimentados con solo forrajes frescos obtuvieron un peso promedio de 2021 g. Las fuentes nutricionales que mejor responden en la alimentación de conejos son, en su orden: ensilaje de botón de oro, ensilaje de morera y ensilaje de ramio.

  5. Estudio de la capacidad estabilizadora del peroné en fracturas de tibia de conejo

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    Fornells Miquel, P.; GÓMEZ BENITO, M.J.; García Aznar, J.M.; BEA CASCAROSA, J.A.

    2008-01-01

    El objetivo de este trabajo es estudiar la capacidad estabilizadora del peroné en fracturas de tibia. Si dicha capacidad es suficiente, sería posible evitar el uso de sistemas de fijación en los experimentos de laboratorio con este tipo de fracturas. Para comprobarlo se ha realizado una simulación computacional por elementos finitos de la tibia y el peroné de un conejo, con una fractura en el tercio medio superior de la diáfisis sin ningún elemento estabilizador. El conjunto ha sido sometido ...

  6. Capacidad condrogénica de injertos libres de periostio en la reparación de defectos del cartílago articular: estudio experimental en conejos

    OpenAIRE

    1996-01-01

    Ante la incapacidad de reparación de las lesiones del cartílago articular, hemos diseñado un modelo experimental, consistente en la realización de una úlcera condral de 8 mm, en la superficie articular de la rótula, en 48 conejos distribuidos en 2 series. Mientras en la serie control (24 conejos) dicha úlcera se dejó a evolución espontánea, en la experimental (24 conejos) fue cubierta con plastia libre de periostio tibial para poder investigar la posibilidad de regeneración del...

  7. Toxicología aguda del D-004 en conejos

    OpenAIRE

    Ariadne Gutiérrez Martínez; Rafael Gámez Menéndez; Rosa Más Ferreiro; Miriam Noa Puig; Balia Pardo Acosta; Eddy Goicochea Carrero; Dayisell Curveco Sánchez; Haydée García Cambián

    2007-01-01

    El D-004 es un extracto lipídico obtenido del fruto de la palma real (Roystonea regia) (Arecaceae) que consiste en una mezcla reproducible de ácidos grasos, en la cual el ácido oleico, el láurico y el palmítico son los más abundantes. El tratamiento oral con D-004 inhibe significativamente la hiperplasia prostática inducida por testosterona en roedores. La toxicología preclínica de un nuevo compuesto incluye la evaluación aguda en una especie no roedora. Con este objetivo se realizó el ensayo...

  8. Oleozon como tratamiento de la dermatomicosis del conejo. (Oleozonas treatment of rabbit dermatomycosis

    Directory of Open Access Journals (Sweden)

    Zullyt Zamora Rodríguez

    2007-03-01

    Full Text Available En este estudio fueron empleados 80 conejos pertenecientes al Centro Nacional para la Producción de Animales de Laboratorio (CENPALAB. Los animales fueron divididos en dos grupos. El primer grupo fue tratado con OLEOZON mientras que al segundo se le aplicó una solución de lugol, previo al comienzo de los tratamientos se arribo al iagnóstico de la patología mediante examen clínico y cultivo de muestras de raspado de piel. Ambos tratamientos fueron aplicados en días alternos culminando con recuperación y cura de los animales. Los resultados demuestran que existen diferencias estadísticamente significativas entre los grupos de tratamientos estudiados, siendomenor el tiempo de curación para el grupo con oleozon, con respecto al grupo tratado con la solución de lugol. Fue demostrado laefectividad del OLEOZON (pinceladas frente a la dermatomicosis del conejo en un rango de aplicaciones de 2 a 8 en correspondenciaal grado de lesión. In this study were used 80 rabbits providedby the National Center for production of Laboratory Animals (CENPALAB. The rabbits were divided in two groups. The firstwas treated with OLEOZON  whereas the second was treated with lugol solution, both applied topically in the rabbit skin damaged.Previously to application of treatments the diagnostic of this disease was obtained by means of clinical findings and the culture ofskin scrapings. Both treatments were applied every other day up to animal recovery and cure.

  9. La cría en jaulas y las necesidades etológicas del conejo

    OpenAIRE

    Finzi, Alessandro; Negretti, Paolo; Macchioni, P; González Redondo, Pedro

    2009-01-01

    Se relaciona una serie de ensayos planeados para averiguar las condiciones de bienestar de los conejos criados en sistemas artificiales. Se evidencia que los animales, cuando puedan escoger, prefieren quedarse en la jaula antes que en un prado, cuando ambos sean libremente accesibles. Se demuestra que, aunque en jaulas separadas, los conejos establecen relaciones sociales; se miran entre ellos más que en otras direcciones y se comprueba que tienen también una relación social olfat...

  10. Estudio experimental en el conejo del proceso de reparación de los defectos osteocondrales mediante el empleo de un injerto de periostio y un biomaterial

    OpenAIRE

    Cebamanos Celma, Juan

    2008-01-01

    Títol obtingut de la portada digitalitzada Consultable des del TDX La reparación de los defectos osteocondrales en la rodilla del conejo ha sido realizada mediante la utilización de: 1. Un injerto libre de periostio invertido (con su capa interna dirigida a la cavidad articular) 2. Un biomaterial (fosfato tricalcico-hidroxiapatita), con el objetivo de reemplazar al cartílago y hueso respectivamente. Se utilizaron 25 conejos, machos, adolescentes, de raza New Zealand y se realizó un defe...

  11. EFECTO DEL DIMETILSULFÓXIDO EN UN MODELO ANIMAL DE NEFROTOXICIDAD INDUCIDA POR GENTAMICINA EN CONEJOS

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    Oscar Francisco López Núñez

    2013-07-01

    Full Text Available Objetivo: La utilidad clínica de la gentamicina se ve limitada por sus efectos deletéreos renales, causados principalmente por daño oxidativo. Dado que el dimetilsulfóxido posee propiedades antioxidantes, se plantea su uso como agente nefroprotector en un modelo animal. Métodos: Se distribuyeron de forma aleatoria 24 conejos en 3 grupos (A, B y C, se administró durante 5 días solución salina normal 0,9%(SSN para el grupo A, gentamicina más SSN para el grupo B y gentamicina más dimetilsulfóxido al 25% para el grupo C. Se determinaron los parámetros: creatinina sérica, actividad enzimática (n-acetyl-b-d-glucosaminidasa urinaria e histopatología renal. Resultados: La creatinina aumentó respecto al valor basal en los grupos B y C (p=0,009. La comparación del incremento entre grupo A vs C mostró significancia estadística (p=0,0194. La clasificación para lesión renal aguda RIFLE fue del 25% y 50% en estadío Riesgo para los grupos C y B respectivamente y 12,5% en estadío Injuria para el grupo B. La actividad de n-acetyl-b-d-glucosaminidasa urinaria presentó incrementos en todas sus mediciones (p<0,05. La histopatología reveló necrosis mayor del 50% de los túbulos proximales en el 25% del grupo C y 87,5% del grupo B, así como necrosis total en 12,5% del grupo B. Se observaron diferencias entre el grupo A vs B (p<0,001 y C (p<0,05. Conclusiones: El modelo planteado induce nefrotoxicidad. El uso de dimetilsulfóxido no redujo el incremento en los niveles de creatinina y en actividad enzimática, mientras que la Lesión Renal Aguda (LRA por evaluación histopatológica presentó una leve mejoría que carece de respaldo estadístico. Palabras Clave: Dimetilsulfóxido, gentamicina, lesión renal aguda, radicales libres

  12. EFECTO DEL DIMETILSULFÓXIDO EN UN MODELO ANIMAL DE NEFROTOXICIDAD INDUCIDA POR GENTAMICINA EN CONEJOS

    Directory of Open Access Journals (Sweden)

    Oscar Francisco López Núñez

    2013-01-01

    Full Text Available Objetivo: La utilidad clínica de la gentamicina se ve limitada por sus efectos deletéreos renales, causados principalmente por daño oxidativo. Dado que el dimetilsulfóxido posee propiedades antioxidantes, se plantea su uso como agente nefroprotector en un modelo animal. Métodos: Se distribuyeron de forma aleatoria 24 conejos en 3 grupos (A, B y C, se administró durante 5 días solución salina normal 0,9%(SSN para el grupo A, gentamicina más SSN par el grupo B y gentamicina más dimetilsulfóxido al 25% para el grupo C. Se determinaron los parámetros: creatinina sérica, actividad enzimática (n-acetyl-b-d-glucosaminidasa urinaria e histopatología renal. Resultados: La creatinina aumentó respecto al valor basal en los grupos B y C (p=0,009. La comparación del incremento entre grupo A vs C mostró significancia estadística (p=0,0194. La clasifica- ción para lesión renal aguda RIFLE fue del 25% y 50% en estadío Riesgo para los grupos C y B respectivamente y 12,5% en estadío Injuria para el grupo B. La actividad de n-acetyl-b-d-glucosaminidasa urinaria presentó incrementos en todas sus mediciones (p<0,05. La histopatología reveló necrosis mayor del 50% de los túbulos proximales en el 25% del grupo C y 87,5% del grupo B, así como necrosis total en 12,5% del grupo B. Se observaron diferencias entre el grupo A vs B (p<0,001 y C (p<0,05. Conclusiones: El modelo planteado induce nefrotoxicidad. El uso de dimetilsulfóxido no redujo el incremento en los niveles de creatinina y en actividad enzimática, mientras que la Lesión Renal Aguda (LRA por evaluación histopatológica presentó una leve mejoría que carece de respaldo estadístico.

  13. USOS DE LA MORERA (Morus alba EN LA ALIMENTACIÓN DEL CONEJO. EL ROL DE LA FIBRA Y LA PROTEÍNA EN EL TRACTO DIGESTIVO

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    David Mora-Valverde

    2010-01-01

    Full Text Available El objetivo de este trabajo fue recopilar las principales características de la digestión del conejo, enfocándose en la digestibilidad de la fibra y la proteína de la dieta para valorar el potencial desempeño de un material con características como la morera. El sistema selectivo de fibra con el que cuenta este lagomorfo, le otorga una ventaja alimenticia especializada ya que excreta de manera eficiente los materiales de baja calidad. La composición bromatológica de la morera y su elevada digestibilidad la hacen muy promisoria para su incorporación en dietas de conejos, exigiendo la evaluación de ésta desde diversos niveles de inclusión, los cuales permitan definir márgenes de sostenibilidad que mejoren su uso en conejos. Se presenta información sobre el empleo de esta fuente en dietas para conejos.

  14. Participación de enzimas translocasas en la reacción acrosomal del espermatozoide de conejo

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    Mayren-Mendoza, Félix de Jesús

    2012-01-01

    Full Text Available ResumenEste estudio se realizó con la finalidad de evaluar la participación de enzimas translocadoras de fosfolípidos en el proceso de reacción acrosomal, en espermatozoides de conejo obtenidos de la región caudal del epidídimo, utilizando la progesterona como inductor de reacción acrosomal y NEtilmaleimida como inhibidor de translocasas.SummaryThis study was conducted in order to evaluate the participation of translocating enzymes of phospholipids in the reaction process acrosomal in rabbit sperm obtained from the caudal region of epididymis, using progesterone as inducer of acrosome reaction and N-ethylmaleimide as an inhibitor of translocase.

  15. Indicadores del valor nutritivo del Hidroforraje de Leucaena leucocephala para la alimentación de conejos - Nutritive values indicators of the Leucaena leucocepahla hydroforage for rabbit feeding

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    López Valoy, B

    2012-02-01

    Full Text Available RESUMENLos hidroforrajes son alimentos considerados de alto valor nutricional. Con el objetivo de determinar indicadores del valor nutritivo del hidroforraje de Leucaena (HFL para ser utilizado en la alimentación de los conejos, serealizaron las siguientes determinaciones: composición química del alimento, perfil aminocídico, presencia de metabolitos secundarios, propiedades físicas y digestibilidad in vitro.AbstractHydroforages are considered as feed of a high nutritive value. The main aim of this survey was to determine the indictors of the Leucaena leococephala hydroforage (LHF nutritive value to be used in feeding rabbits. The fallowing aspects were taken into account to reach such objective: feed chemical composition, aminoacid profile, presence of secondary metabolites, physical properties and invitro digestibility. In an experiment it was used a completely aleatorized design.

  16. Efecto del injerto óseo humano liofilizado y membrana amniótica humana liofilizada en la regeneración ósea en tibias de conejos

    OpenAIRE

    Paredes Nomberto, Frank; Unidad de Posgrado de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos, Perú.

    2016-01-01

    El presente estudio tuvo como objetivo investigar el efecto del injerto óseo humano liofilizado particulado en combinación con la membrana amniótica humana liofilizada en la regeneración ósea en tibias de conejos. Metodología. Se utilizaron 10 Conejos raza Nueva Zelanda, de 6 a 9 meses de edad aproximadamente, hembras y machos en buen estado, de 3.5 Kg-4 Kg de peso, en los que se crearon defectos circulares óseos de 4mm de diámetro en la región más inferior de las extremidades posteriores del...

  17. CALIDAD DE LA CARNE Y CONTAMINACIÓN MICROBIOLÓGICA POR Staphylococcus aureus METICILINA RESISTENTES EN CANALES DE CONEJOS (Oryctolagus cuniculus) PROCEDENTES DE UNIDADES DE PRODUCCIÓN FAMILIAR DEL VALLE DE TOLUCA

    OpenAIRE

    Rodriguez Correa, Juan Luis

    2016-01-01

    La estrecha relación entre la dieta y la salud ha conducido a cambios en los hábitos del consumidor. En este contexto, la carne de conejo es muy valorada por sus propiedades nutricionales y dietéticas. Por las características que tiene la carne es un buen sustrato para la contaminación cruzada. El S. aureus es un patógeno que afecta a humanos y animales. En los conejos puede causar mastitis, dermatitis exudativa, abscesos subcutáneos y septicemias. El uso indiscriminado de antibióticos como t...

  18. Análisis a largo plazo del cartílago producido por injertos libres de periostio tibial en lesiones articulares del cóndilo femoral del conejo

    OpenAIRE

    1999-01-01

    Propósito de estudio: Analizar la reparación de lesiones del cartílago articular con injertos libres de periostio. Material y Métodos: 36 conejos de Nueva Zelanda, de 4 a 6 semanas. Creación de úlcera condral en cóndilo femoral interno. Evolución espontánea en 18 animales. Tratamiento con injerto libre de periostio tibial fijado con Tissucol R en otros 18 animales. Sacrificio en grupos de 67 animales a las 8, 12 y 24 semanas. Valoración de resultados macroscópicos, histológicos e histoquímico...

  19. EVALUACIÓN HISTOLÓGICA DE BIOCOMPATIBILIDAD Y BIOCONDUCCIÓN DEL COMPUESTO HIDROXIAPATITA - LIGNINA IMPLANTADO EN TIBIA DE CONEJOS

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    Marlene Vargas V

    2009-04-01

    Full Text Available Objetivo. Evaluar histologicamente la biocompatibilidad y propiedad óseoconductora del compuesto de hidroxiapatita - lignina implantado en tibias de conejos. Material y métodos. Se utilizaron 20 conejos de raza nueva Zelanda, en cada uno, la tibia izquierda fue tratada con el compuesto y la tibia derecha no fue tratada y sirvió como control. Con la ayuda de taladro manual y una broca se realizó un defecto óseo de aproximadamente 4 mm de diámetro en la superficie lateral proximal tibial, hasta alcanzar el canal medular. Dos comprimidos del compuesto (400 mg, se utilizaron para rellenar el defecto. El mismo procedimiento quirúrgico se realizó en el grupo control, sin la utilización del compuesto. Las evaluaciones histológicas se realizaron a los 8, 30, 60, 90 y 120 días postcirugía, para lo que fue necesaria la eutanasia de 4 animales por fecha de evaluación. Resultados. En las evaluaciones de 30, 60, 90 y 120 días se observó una formación ósea más acelerada y extensa en el grupo tratado al compararse las lecturas histológicas con el grupo control. Conclusiones. El compuesto hidroxiapatita-lignina permitió el crecimiento de tejido óseo desde los bordes hasta el centro del defecto a un ritmo de crecimiento mayor, con formación de hueso mas organizado que en el grupo control. Además se observó su integración al tejido óseo; lo que sugiere su biocompatibilidad y propiedad óseoconductora, hecho que permite recomendarlo como substituto.

  20. Solución adyuvante CM-95 tratada magnéticamente en comparación con el adyuvante de Freund para la obtención del suero de Coombs en conejo

    OpenAIRE

    Clara Martínez; Marlene Toledano; Gustavo Rodríguez; Leagne Andina; Iztiz Lassalle; Gustavo Sierra

    2009-01-01

    En este trabajo se evaluó la aplicación de la solución CM-95 tratada magnéticamente como adyuvante inmunológico, en comparación con el adyuvante de Freund, para la obtención del suero de Coombs en conejos, de gran demanda en bancos de sangre y hospitales, para el diagnóstico clínico de conflictos Rh y la enfermedad hemolítica del recién nacido, entre otras. Conejos Nueva Zelanda Blancos se inocularon por la vía subcutánea con suero humano obtenido de 30 donantes O+, unido con la solución CM-9...

  1. Conejos. Muy meritorios, pero poco reconocidos.

    OpenAIRE

    Camps Rabadà, Jaume

    2011-01-01

    Los conejos son la única especie animal doméstica de origen europeo, y además, fue formada en nuestra península, único lugar relacionado con su evolución, con la etimología del nombre de España, y con su historia, dentro del pasado. Y, ya en la actualidad, la cría de conejos es importante por su relación con la economía, tanto en la balanza import-export, como en la producción ganadera, y, sobre todo, y muy destacable, con nuestra salud nutricional. A pesar de estos “méritos”, suelen ser, en ...

  2. Reparación de lesiones del cartílago articular de la rótula de conejos con injertos libres de pericondrio costal y periostio tibial: Estudio histológico comparativo

    OpenAIRE

    1998-01-01

    El propósito del presente, estudio experimental es comparar la capacidad condrogénica de injertos libres de pericondrio y periostio en lesiones que afectan a todo el espesor del cartílago articular rotuliano. Para ellos, se eligieron 18 conejos adolescentes de Nueva Zelanda con un peso comprendido entre los 2400 y 3600 gramos, a los que se realizó una lesión de 6 mm de diámetro y 3 mm de espesor en la superficie articular de la rótula, y se distribuyeron de modo aleatorio en tres grupos: con...

  3. New Age Fairy Tales: The Abject Female Hero in El laberinto del fauno and La rebelión de los conejos mágicos

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    Patricia Lapolla Swier

    2011-11-01

    Full Text Available In totalitarian regimes, the Other is marginalized, prosecuted, and often eliminated from the national spectrum. While Spain is just beginning to confront the violations of the post-Civil War era, the nations of the Latin American Southern Cone have continued to struggle with the trauma and memory related to the violence perpetrated by the dictatorship. Through a psychoanalytic reading based on Julia Kristeva's theories of the abject and Joseph Campbell's investigations of myth within the hero's journey, I show how the young female heroes of El laberinto del fauno (Pan's Labyrinth and La rebelión de los conejos mágicos (The Rabbits' Rebellion embark upon a journey of personal self-discovery and self-transcendence in the marginal space of the abject, and how, by doing so, they release the repressed stories of the victims of these dictatorships. Through their journeys in these fairy-tale settings emerges a transformation of consciousness that provides more comprehensive readings of history at the universal level.

  4. Coccidiosis hepática en el conejo: aspectos ambientales y clínico-patológicos

    OpenAIRE

    Mario Pérez Martínez; Miguel Angel Betancourt Alonso

    2011-01-01

    La cunicultura es una industria creciente en México. De las 13 especies de coccidias que afectan a los conejos, la Eimeria stiedae es el principal agente causal de la coccidiosis hepática en el conejo. En la presente revisión se aborda la importancia del medio ambiente y aspectos clínico- patológicos de la coccidiosis hepática en conejos. Como resultado de la revisión de la literatura disponible se observa la necesidad de abordar el estudio de la coccidiosis hepática del conejo de manera inte...

  5. EFECTO NEFROPROTECTOR DEL ÁCIDO ASCÓRBICO EN UN MODELO DE DAÑO RENAL INDUCIDO POR GENTAMICINA EN CONEJOS

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    Javier Antonio Padilla Funes

    2013-08-01

    Full Text Available Objetivo. Uno de los efectos secundarios mas notables de la Gentamicina es su nefrotoxicidad. En este estudio se propone el posible efecto nefroprotector del acido ascorbico como barredor de radicales libres de oxigeno. Metodología. Se ejecuto un estudio experimental en 24 conejos machos, raza Nueva Zelanda, cuyo peso fue de 1,5 +/- 0,5 Kg. Los sujetos experimentales fueron distribuidos en tres grupos. El grupo Control se manejo con Gentamicina a dosis de 80 mg/Kg/dia por via IM. El grupo Acido Ascorbico se trato a dosis de 200 mg/kg/dia via IP y Gentamicina 80mg/Kg/dia IM. El grupo Sham se manejo con SSN 0,9% por via IP e IM, durante cinco dias consecutivos, para cada grupo. Se determinaron los siguientes parametros: creatinina serica, N-Acetil s-D glucosaminidasa urinaria (NAG-U, diuresis e histopatologia de las muestras renales. Resultados. La creatinina serica fue significativamente mayor para el grupo Control respecto al grupo Acido Ascorbico (p<0,05. Respecto a la diuresis, se observo una tendencia a la poliuria en el grupo Control. En cuanto a NAG-U, se observo inhibicion completa de la actividad enzimatica en el grupo Acido Ascorbico. El analisis histopatologico demuestra hallazgos de necrosis tubular aguda en el 100% del grupo control, mientras que en el grupo Acido Ascorbico se obtuvo en un 50% de los sujetos unicamente detritos intraluminales. Conclusiones. La administracion concomitante de Acido Ascorbico con Gentamicina, disminuye significativamente el dano tubular renal, evidenciado en los valores de creatinina serica, NAG, diuresis e histopatologia renal.

  6. EFECTO NEFROPROTECTOR DEL ÁCIDO ASCÓRBICO EN UN MODELO DE DAÑO RENAL INDUCIDO POR GENTAMICINA EN CONEJOS

    Directory of Open Access Journals (Sweden)

    Javier Antonio Padilla Funes

    2012-01-01

    Full Text Available Objetivo. Uno de los efectos secundarios más notables de la Gentamicina es su nefrotoxicidad. En este estudio se propone el posible efecto nefroprotector del ácido ascórbico como barredor de radicales libres de oxígeno. Metodología. Se ejecutó un estudio experimental en 24 conejos machos, raza Nueva Zelanda, cuyo peso fue de 1,5 +/- 0,5 Kg. Los sujetos experimentales fueron distribuidos en tres grupos. El grupo Control se manejó con Gentamicina a dosis de 80 mg/Kg/día por vía IM. El grupo Ácido Ascórbico se trató a dosis de 200 mg/kg/día vía IP y Gentamicina 80mg/Kg/día IM. El grupo Sham se manejó con SSN 0,9% por vía IP e IM, durante cinco días consecutivos, para cada grupo. Se determinaron los siguientes parámetros: creatinina sérica, N-Acetil ß-D glucosaminidasa urinaria (NAG-U, diuresis e histopatología de las muestras renales. Resultados. La creatinina sérica fue significativamente mayor para el grupo Control respecto al grupo Ácido Ascór- bico (p<0,05. Respecto a la diuresis, se observó una tendencia a la poliuria en el grupo Control. En cuanto a NAG-U, se observó inhibición completa de la actividad enzimática en el grupo Ácido Ascórbico. El análisis histopatológico demuestra hallazgos de necrosis tubular aguda en el 100% del grupo control, mientras que en el grupo Ácido Ascórbico se obtuvo en un 50% de los sujetos únicamente detritos intraluminales. Conclusiones. La administración concomitante de Ácido Áscórbico con Gentamicina, disminuye significativamente el daño tubular renal, evidenciado en los valores de creatinina sérica, NAG, diuresis e histopatología renal.

  7. Efecto del entrenamiento físico sobre los factores endoteliales en el sistema arterial de conejo

    OpenAIRE

    Marchio, Patricia

    2015-01-01

    Las enfermedades cardiovasculares constituyen una de las primeras causas de mortalidad en la población occidental y prácticamente el 50% se podrían prevenir con modificaciones del estilo de vida. En este sentido, la práctica regular de ejercicio físico se asocia con una reducción de entre un 20 a un 40% de la incidencia de eventos vasculares primarios y secundarios y del riesgo de muerte por enfermedad cardiovascular. Parte de estos beneficios estarían relacionados con los efectos directos y ...

  8. Entre conejos y alegrías: Proceso productivo y valoración del amaranto en Tochimilco, Puebla.

    OpenAIRE

    Santamaría Llerandi, Alejandra Carolina

    2014-01-01

    La presente investigación tiene como objetivo dar a conocer cuál es el manejo, el uso y la valoración del amaranto en la región de Tochimilco, Puebla y proponer una estrategia de desarrollo rural. Para lograr este fin se trabajó con: la historia oral, encuestas, observación participante, entrevistas guiadas que permitieron la elaboración de una etnografía; así como un análisis FODA para generar una estrategia que permita darle mayor uso y valor al amaranto para su consumo en la región y valor...

  9. Consideraciones prácticas acerca de la calidad del semen de conejos aplicado en estudios de toxicología de la fertilidad (Practice considerations about the semen quality of rabbits for applied in fertility toxicology study.

    Directory of Open Access Journals (Sweden)

    Arencibia Arrebola Daniel Francisco

    2009-08-01

    Full Text Available ResumenEl conejo doméstico es un descendiente del conejo salvaje que habitaba en el oeste de Europa y en el noroeste de África. En los estudios de toxicología experimental se destaca su uso en la determinación de toxicidad por irritación dérmica, ocular, toxicología de vacunas, además de ser básico como modelo animal para determinar compuestos teratogénicos, los cuales influyen tanto en la fertilidad de la hembra como en la del macho. Los métodos para la valoración de la calidad del semen, tanto para la inseminación artificial como en la investigación, están sufriendo un constante desarrollo para intentar estimar con mayor precisión la fertilidadde los machos. Desafortunadamente, las valoraciones de laboratorio nopredicen con exactitud la fertilidad y tampoco se obtiene una repetitividad de unos análisis a otros, debido a la subjetividad de muchas de dichas valoraciones. El objetivo de este trabajo es la confección de una guía teórico-práctica que permita realizar estudios del semen en conejos de la raza Nueva Zelanda Blanca, aplicado a la temática de toxicología de la fertilidad. Trataremos los temas de inducción del celo en las hembras, condiciones y método para la extracción del semen, pruebas macroscópicas y microscópicas del semen, valoración del peso de órganos y examen anatomopatológico. Todas las pruebas descritas aportan datos que nosindicarán una disminución de la calidad del semen, pero debemos realizar valoraciones que nos aporten sencillez, rapidez y que sean económicamente viables; para ello cada investigador debe utilizar aquellas que mejor se adapten a sus condiciones de trabajo.SummaryThe domestic rabbit is descendend from the wilds rabbits was to inhabited of western Europe and Northwestern Africa. The rabbits is very usefull in the experimental Toxicology study, in dermal irritation, ocular irritation and the vaccines Toxicology, beside is a basic animal models in teratogenicity evaluation of

  10. Las Manas de Tio Conejo (Uncle Conejo's Tricks).

    Science.gov (United States)

    Kennedy, James H.

    A lesson is presented that is designed to assist intermediate and advanced students of Spanish in both language proficiency and cultural understanding. Entirely in Spanish, the lesson focuses on the character of Tio Conejo, a well-known figure in Latin American folklore, offering insight into the significant contribution made to Hispanic…

  11. Solución adyuvante CM-95 tratada magnéticamente en comparación con el adyuvante de Freund para la obtención del suero de Coombs en conejo

    Directory of Open Access Journals (Sweden)

    Clara Martínez

    2009-12-01

    Full Text Available En este trabajo se evaluó la aplicación de la solución CM-95 tratada magnéticamente como adyuvante inmunológico, en comparación con el adyuvante de Freund, para la obtención del suero de Coombs en conejos, de gran demanda en bancos de sangre y hospitales, para el diagnóstico clínico de conflictos Rh y la enfermedad hemolítica del recién nacido, entre otras. Conejos Nueva Zelanda Blancos se inocularon por la vía subcutánea con suero humano obtenido de 30 donantes O+, unido con la solución CM-95 tratada magnéticamente como adyuvante inmunológico. Se empleó un esquema de inmunización de 40 días, donde se evaluó la dinámica en el título de anticuerpos anti IgG humano por la técnica de hemoaglutinación en tubos. Al antisuero se le determinó la calidad inmunológica por el título de heteroaglutininas de los grupos sanguíneos A, B y O, de anticuerpos anticomplemento C3b, C3d y C4b y anti IgG, antes y después de su purificación. El suero de Coombs con la solución adyuvante CM-95 tratada magnéticamente mostró valores similares a los obtenidos con el adyuvante de Freund. En el mismo se cumplió con los requisitos establecidos por el Centro Estatal para el Control de la Calidad de los Medicamentos, según las normativas de la FDA para este diagnosticador. Estos resultados abren nuevas perspectivas para el uso de la solución adyuvante en la obtención del suero de Coombs.

  12. Coccidiosis hepática en el conejo: aspectos ambientales y clínico-patológicos

    Directory of Open Access Journals (Sweden)

    Mario Pérez Martínez

    2010-01-01

    Full Text Available La cunicultura es una industria creciente en México. De las 13 especies de coccidias que afectan a los conejos, la Eimeria stiedae es el principal agente causal de la coccidiosis hepática en el conejo. En la presente revisión se aborda la importancia del medio ambiente y aspectos clínico- patológicos de la coccidiosis hepática en conejos. Como resultado de la revisión de la literatura disponible se observa la necesidad de abordar el estudio de la coccidiosis hepática del conejo de manera integral, y avanzar en la comprensión de los mecanismos celulares y moleculares involucrados en su patogenia.

  13. Coccidiosis hepática en el conejo: aspectos ambientales y clínico-patológicos

    Directory of Open Access Journals (Sweden)

    Mario Pérez Martínez

    2011-01-01

    Full Text Available La cunicultura es una industria creciente en México. De las 13 especies de coccidias que afectan a los conejos, la Eimeria stiedae es el principal agente causal de la coccidiosis hepática en el conejo. En la presente revisión se aborda la importancia del medio ambiente y aspectos clínico- patológicos de la coccidiosis hepática en conejos. Como resultado de la revisión de la literatura disponible se observa la necesidad de abordar el estudio de la coccidiosis hepática del conejo de manera integral, y avanzar en la comprensión de los mecanismos celulares y moleculares involucrados en su patogenia.

  14. Análisis del comportamiento mecánico en una sección de la aorta // Mechanical behavior analysis in an aorta section

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    A. González-Martin

    2009-05-01

    Full Text Available La importancia social de las enfermedades arteriales motiva el interés en desarrollar estudios sobreel comportamiento mecánico de las paredes arteriales que aporten información para la prácticamédica, ya que estas enfermedades están fuertemente relacionadas con factores mecánicos comoson los estados de deformación y tensión. El presente trabajo ofrece una metodología para analizarel comportamiento mecánico de una arteria (la aorta. Dicho análisis parte de una geometría realconstruida a partir de imágenes médicas. En la formulación del modelo de elementos finitos seescogió un material con comportamiento no-lineal, con grandes deformaciones, hiperelástico, nohomogéneoy ortótropico. A la hora de analizar los resultados logrados y compararlos con losresultados obtenidos por otros autores no es posible establecer una comparación debido a losdiferentes métodos de ensayo empleados por distintos autores y la dificultad en laexperimentación en arterias humanas, solo es posible establecer zonas criticas en las cuales sepresente algún tipo de enfermedad arterial.Palabras claves: aorta, modelación, elementos finitos (EF, hiperelásticidad.______________________________________________________________________________AbstractThe social importance of the arterial illnesses motivates the interest in developing studies on themechanical behavior of the arterial walls. The medical practice has pointed that these illnesses arestrongly related with mechanical factors, such as states of deformation and tension as other relatedparameters. The present work offers a methodology to analyze the mechanical behavior of anartery (the aorta. This analysis uses a real geometry model that has been built based on medicalimages. In the formulation of the finite elements model the material has been considered with ano-linear behavior, with big deformations, hyperplasic, no-homogeneous and orthotropic. It is notpossible to establish comparisons between the

  15. Conejo Oryctolagus cuniculus (Linnaeus, 1758)

    OpenAIRE

    2016-01-01

    Salgado I. 2016. Conejo Oryctolagus cuniculus (Linnaeus, 1758). En: Calzada J., Clavero M. & Fernández A. (eds). “Guía virtual de los indicios de los mamíferos de la Península Ibérica, Islas Baleares y Canarias”. Sociedad Española para la Conservación y Estudio de los Mamíferos (SECEM). http://www.secem.es/guiadeindiciosmamiferos/ Downloaded on "12/12/2016”

  16. Modificaciones del patrón fibrilatorio ventricular por el estiramiento regional del ventrículo izquierdo: estudio en corazón aislado de conejo.

    OpenAIRE

    Trapero Gimeno, Isabel

    2006-01-01

    RESUMEN Introducción: Se parte de la hipótesis de que las modificaciones locales de las propiedades electrofisiológicas, si se circunscriben a zonas de extensión limitada, deben causar escasos cambios en el proceso global de activación durante la fibrilación ventricular (FV). Para comprobarlo, se produce un estiramiento local del miocardio, en la pared libre del ventrículo izquierdo, y se analizan diversos parámetros electrofisiológicos, tanto en situación de ritmo sinusal como durante la ...

  17. Efecto del láser infrarrojo de uso clínico sobre el perineuro de nervio isquiático de conejo Effect of the clinical infrared laser on the perineurium of rabbit isquiatic nerve

    Directory of Open Access Journals (Sweden)

    F. Matamala

    2001-01-01

    Full Text Available El rayo láser infrarrojo se utiliza para obtener disminución del dolor, aumento de la reparación tisular y disminución de la inflamación. El propósito de este trabajo fue comprobar la respuesta del tejido colágeno del perineuro de nervio isquiático sano de conejo, ante la estimulación del rayo láser infrarrojo. Se irradiaron transcutáneamente 10 conejos según el esquema habitual de tratamientos kinésicos. Los nervios irradiados y los controles fueron tratados con técnicas histológicas para tejido colágeno. La medición del espesor del perineuro se efectuó con un retículo ubicado en el ocular de un microscopio de luz. El perineuro de los nervios irradiados presentó mayor espesor que los controles, comprobado por análisis estadístico computacional. Se observó gran cantidad de tejido adiposo alrededor del nervio y aumento de volumen de los nervios irradiados. Se concluye que la aplicación de rayos láser infrarrojos sobre nervios periféricos produce variaciones en la morfología normal de estos nervios.The infrared laser beam employed as a Low Level Laser Therapy (LLLT is postulated by many authors as pain reliever and scar tissue healing by increasing cellular metabolism, irrigation and tisular cells repairing. The main goal of this experience was to check the thickness of healthy rabbit isquiatic perineurium nerve, which were irradiated with infrared laser. In each session, ten healthy rabbits were irradiated on the skin of the rigth leg with 10 Joule/cm² energy during 9 minutes to complete 10 of them, according to the rules of kinesic treatment. The animals were sacrified and their legs dissected , extracting the right and left isquiatic nerves. All nerves were treated by histologic procedure in order to observe colagen tissue (Van Giesson and Mallory methods .The left side nerve was used as a control. Perineurium thickness measurement was performed with a reticulated micrometer (400 X 0,25mm² located at the ocular

  18. MAMÍFEROS INVASORES EN LA PATAGONIA ARGENTINA: EL CONEJO SILVESTRE EUROPEO COMO CASO EMBLEMÁTICO

    Directory of Open Access Journals (Sweden)

    Never Antonio Bonino Vassallo

    2010-04-01

    Full Text Available Se brinda una reseña de los estudios biológicos y ecológicos realizados sobre el conejo silvestre europeo (Oryctolagus cuniculus, tal vez el más emblemático de los mamíferos exóticos introducidos en Argentina. En el sector continental argentino el conejo se encuentra establecido, y en proceso de dispersión, principalmente en las provincias de Mendoza y Neuquén (NO de la Patagonia. En esta región, el conejo ha demostrado tener un efecto negativo sobre la economía regional, especialmente en áreas ganaderas y en plantaciones comerciales de árboles frutales y maderables. No existen programas oficiales para controlar la dispersión geográfica y/o el impacto de esta especie exótica. La gente que se siente perjudicada por el conejo recurre a intentos individuales para controlar sus efectos negativos. Es necesario implementar monitoreos regulares de la dispersión del conejo para la detección temprana y el manejo de poblaciones recién establecidas; además, se requieren estudios comparativos tendientes a determinar los métodos más adecuados para controlar el impacto del conejo.

  19. Toxicología aguda en conejos del D-005, extracto lipídico del fruto de Acrocomia Crispa (palma corojo)

    OpenAIRE

    Ariadne Gutiérrez-Martínez; Carlos Nodal-Flores; Isury Bucarano-Lliteras; Regla Placeres-Hernández; Zenaida Tolón-Gato; Edy Goicochea-Carrero

    2016-01-01

    El D-005 es un extracto lipídico del fruto de Acrocomia crispa (palma corojo), palma endémica de la familia Arecaceae, que contiene una mezcla de ácidos grasos, principalmente láurico, oleico, mirístico y palmítico y en menores proporciones esteárico, caprílico, cáprico y palmitoleico. El tratamiento con D-005 por vía oral redujo el agrandamiento prostático inducido por testosterona en ratas. La toxicología preclínica de un nuevo compuesto incluye la evaluación aguda en una especie no roedora...

  20. Perfil del peso corporal en la isquemia mesentérica aguda: Estudio experimental en conejos Nueva Zelanda Body weight profile in acute mesenteric ischemia: Experimental study in New-Zealand rabbits

    Directory of Open Access Journals (Sweden)

    J. F. Guijarro Escribano

    2005-12-01

    Full Text Available Introducción y objetivos: Hay pocos trabajos de investigación que relacionen la isquemia mesentérica aguda y el peso corporal en la experimentación animal. Se pretende estudiar, si la pérdida de peso inicial, está relacionada con la magnitud de la agresión provocada por los clampajes de la arteria mesentérica superior durante 30 y 60 minutos, y si la isquemia reperfusión puede dificultar la recuperación ponderal del peso en los animales supervivientes, al final de las 11 semanas del trabajo experimental con conejos Nueva Zelanda, mediante un modelo experimental válido. Material y método: Se distribuyeron 80 animales (conejos en cuatro series de 20: serie I (control, los animales fueron pesados durante 11 semanas; serie II (operación simulada, serie III (isquemia mesentérica 30 minutos y serie IV (isquemia mesentérica 60 minutos. Provocamos la isquemia por pinzamiento de la arteria mesentérica superior. Los animales de las series II, III y IV fueron pesados 24 horas antes del procedimiento quirúrgico y semanalmente en el postoperatorio durante su supervivencia hasta completar 11 semanas. Para el análisis de los pesos, se aplicó un ANOVA enfrentando la variación del peso porcentual en función de la serie. Todos los animales fueron necropsiados para conocer la causa del fallecimiento y las lesiones histológicas de la mucosa intestinal Resultados: La serie control tuvo un incremento lineal del peso hasta el final del período de observación. Las series II, III y IV sufrieron un descenso proceinicial significativo del peso porcentual en la primera semana del postoperatorio, con una recuperación al final del estudio, pero significativamente menor con respecto a la serie control. También se han encontrado diferencias significativas en la recuperación del peso a las 11 semanas entre la serie II y las series III y IV, y entre las series isquémicas entre sí. Conclusiones: Los animales de las series II, III, y IV alcanzaron al

  1. Efectos de las formulaciones de citronelal ozonizado en el tratamiento de conejos con Dermatomicosis

    Directory of Open Access Journals (Sweden)

    Kendra García Madan

    2010-01-01

    Full Text Available El citronelal ozonizado presenta propiedades antimicrobianas y antifúngicas contra diferentes microorganismos. El objetivo de este estudio fue investigar el efecto de tres formulaciones, al 1, 3 y 5% de citronelal ozonizado y una formulación placebo, comparadas con el OLEOZON Tópico en la Dermatomicosis de conejos. En este estudio se utilizaron 27 conejos blancos de la raza Nueva Zelanda, distribuidos en 6 grupos de la siguiente forma: Grupo I, conejos sin tratamiento; Grupo II, tratados con OLEOZON Tópico; Grupo III, tratados con la formulación 1 (citronelal ozonizado al 3%; Grupo IV, tratados con la formulación 2 (citronelal puro al 5%; Grupo V, tratados con la formulación 3 (citronelal ozonizado al 5% y Grupo VI, tratados con la formulación 4 (citronelal ozonizado al 1%. El diagnóstico de la enfermedad se realizó por inspección visual y raspado profundo y cultivo. Todos los tratamientos se aplicaron tópicamente en días alternos durante 15 días. Como resultado, los animales de los grupos II Y III se curaron en los 15 días, Sin embargo los conejos del grupo II mostraron la piel aceitosa por una semana después de concluido el estudio. La apariencia de la piel sana de los conejos tratados con la formulación al 3% fue mejor en comparación con el grupo tratado con OLEOZON. El resto de los grupos, tratados con las formulaciones al 1 y 3% y con la formulación placebo, no se curaron con los 15 días de tratamiento. Este estudio demuestra la alta efectividad terapéutica de la formulación de citronelal ozonizado al 3% en el tratamiento de la dermatomicosis en conejos.

  2. Efecto protector de Helianthus annuus (girasol sobre el infarto de miocardio en conejos Nueva Zelanda

    Directory of Open Access Journals (Sweden)

    Edith Guardia-Espinoza

    2015-01-01

    Full Text Available Objetivos. Determinar el efecto protector del aceite de Helianthus annuus (Girasol sobre el infarto de miocardio inducido con epinefrina en conejos Nueva Zelanda. Materiales y métodos. Los conejos fueron asignados aleatoriamente en cinco grupos (n= 8 por grupo: blanco, control negativo, experimental 1 (10 mg/kg, experimental 2 (20 mg/kg y experimental 3 (40 mg/kg. Los grupos experimentales 1, 2 y 3 recibieron aceite de Helianthus annuus durante dos semanas. La epinefrina (2 mg/Kg se administró a los grupos control negativo, experimentales 1, 2 y 3 durante dos días consecutivos con un intervalo de 24 h después del pretratamiento con aceite. Veinticuatro horas después de la última administración, los conejos fueron anestesiados y sacrificados. Se evaluaron los niveles séricos de troponina I y número de polimorfonucleares por μm2. Resultados. Se encontró diferencia significativa entre el grupo control negativo y los grupos experimentales 1, 2 y 3 en los variables niveles séricos de troponina I y número de polimorfonucleares por μm2. Conclusiones: El aceite de Helianthus annuus a dosis de 20 mg/kg tiene efecto protector sobre el infarto de miocardio inducido con epinefrina en conejos Nueva Zelanda

  3. Efecto protector de Helianthus annuus (girasol sobre el infarto de miocardio en conejos Nueva Zelanda

    Directory of Open Access Journals (Sweden)

    Edith Guardia-Espinoza

    Full Text Available Objetivos. Determinar el efecto protector del aceite de Helianthus annuus (Girasol sobre el infarto de miocardio inducido con epinefrina en conejos Nueva Zelanda. Materiales y métodos. Los conejos fueron asignados aleatoriamente en cinco grupos (n= 8 por grupo: blanco, control negativo, experimental 1 (10 mg/kg, experimental 2 (20 mg/kg y experimental 3 (40 mg/kg. Los grupos experimentales 1, 2 y 3 recibieron aceite de Helianthus annuus durante dos semanas. La epinefrina (2 mg/Kg se administró a los grupos control negativo, experimentales 1, 2 y 3 durante dos días consecutivos con un intervalo de 24 h después del pretratamiento con aceite. Veinticuatro horas después de la última administración, los conejos fueron anestesiados y sacrificados. Se evaluaron los niveles séricos de troponina I y número de polimorfonucleares por μm2. Resultados. Se encontró diferencia significativa entre el grupo control negativo y los grupos experimentales 1, 2 y 3 en los variables niveles séricos de troponina I y número de polimorfonucleares por μm2. Conclusiones: El aceite de Helianthus annuus a dosis de 20 mg/kg tiene efecto protector sobre el infarto de miocardio inducido con epinefrina en conejos Nueva Zelanda

  4. EL CONEJO EUROPEO EN CHILE: HISTORIA DE UNA INVASIÓN BIOLÓGICA

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    Pablo Camus

    2008-12-01

    Full Text Available Este trabajo analiza las relaciones entre los seres humanos y su ambiente, a partir de la historia de la aclimatación y posterior invasión de conejos en Chile, constatando que, en el largo plazo, las acciones humanas tienen efectos e impactos insospechados sobre el medio natural. En efecto, si bien inicialmente los conejos fueron vistos como una oportunidad de desarrollo económico a partir del aprovechamiento de su piel y su carne, pronto esta especie se convirtió en una plaga difícil de controlar en diversas regiones del país, como Chile central, Tierra del Fuego e islas Juan Fernández. Así, con el paso del tiempo, el conejo se ha terminado por transformar en nuestro país en un verdadero "convidado de piedra".This work analyses the relationship between human beings and their environment taking into consideration the adjustment and eventual invasión of rabbits in Chile. It argües that in the long run, human actions have unsuspected effects upon the environment. In fact rabbits were seen initially as an opportunity for economic development because of the exploitation of their meat and skin. Later, rabbits became a plague in different áreas of Central Chile, Tierra del Fuego and Juan Fernández islands, which was difficult to control. Over the years rabbits became unwelcome guests in Chile.

  5. Bordetella bronchiseptica como un riesgo importante de salud publica. Estudio clínico patológico en conejos

    Directory of Open Access Journals (Sweden)

    Valladares-Carranza B.

    2011-10-01

    Full Text Available ResumenB. bronchiseptica es reconocida como un patógeno primario inicial del tracto respiratorio en animales domésticos, puede provocar tos de las perreras (perro, respiración ruidosa (en conejos y rinitis atrófica (en el cerdo.summary

  6. Evaluación de tres niveles de reemplazo del concentrado comercial por guandul (Cajanus cajan L. en conejos de ceba

    Directory of Open Access Journals (Sweden)

    Borrero Giovanny

    1990-06-01

    Full Text Available En Palmira Colombia se realizó un ensayo utilizando heno de guandul, Cajanus cajan L., para reemplazar concentrado comercial en niveles de 25,50,75 y 100 % con un tratamiento testigo de 100% concentrado comercial. Se emplearon 30 gazapos Nueva Zelanda blancos con una edad de 35 días, distribuídos en un diseño de bloques completamente al azar (BOCA donde el peso fue el factor de bloqueo. Cada bloque de 10 animales. Cada unidad experimental estaba constituida por dos animales alojados en jaulas de 0.3 x 0.6. Cada tratamiento tuvo 3 repeticiones. Se evaluaron las variables ganancia de peso, consumo de materia seca, conversión alimenticia, rendimiento en canal y semanas para alcanzar 2 kg. A medida que aumentó el nivel de guandul disminuyó la ganancia de peso/animal/día y el rendimiento en canal y se necesitó mayor número de semanas para alcanzar los 2 kg de peso. Se registraron mejores resultados en el testigo que en los tratamientos con guandul, sin embargo los resultados del tratamiento del 75 % de concentrado + 25 % de guandul, fueron similares a los del testigo y fue el tratamiento de mayor beneficio neto.In Palmira, Colombia was done an experiment using guandul (Cajanus cajan hay for replacing commercial feed in 25, 50, 75 and 100 % levels with a control treatment, 100 % commercial feed. Thirty white New Zeland rabbits 35 days old , were used and distributed in a Randomized Block Design (RDD where weight was the blocking factor. Each block had 10 animals. Every experimental unit was composed for two rabbits located in one e age (0.3 m x 0.6 m. Each treatment had 3 replications. The following variables were evaluated: weight gain, dry matter consumption, feed efficiency, carcass percentage ad weeks to reach the 2 kg weight. For every increase in guandul hay levels, there was a reduction in daily weight gain and carcass percentage and it was required more time to reach the 2 kg weight. When the control treatment was compared with the

  7. El cuello femoral en la enfermedad de Perthes. Estudio experimental en conejos

    OpenAIRE

    Carranza Bencano, A.

    1999-01-01

    Introducción: Aunque el substrato básico y fundamental de la enfermedad de Perthes es la osteocondritis por isquemia del núcleo de osificación de la extremidad proximal del fémur, no se ha conseguido la reproducción experimental de la misma. Objetivo: Reproducir experimentalmente,en el conejo, la isquemia del núcleo epifisario y comprobar si las lesiones obtenidas son superponibles a las conocidas de esta enfermedad en el hombre. Observar la evolución de estas lesiones y poder ...

  8. Análisis del comportamiento mecánico en una sección de la aorta

    Directory of Open Access Journals (Sweden)

    A. González-Martin

    2009-05-01

    Full Text Available La importancia social de las enfermedades arteriales motiva el interés en desarrollar estudios sobre el comportamiento mecánico de las paredes arteriales que aporten información para la práctica médica, ya que estas enfermedades están fuertemente relacionadas con factores mecánicos como son los estados de deformación y tensión. El presente trabajo ofrece una metodología para analizar el comportamiento mecánico de una arteria (la aorta. Dicho análisis parte de una geometría real construida a partir de imágenes médicas. En la formulación del modelo de elementos finitos se escogió un material con comportamiento no-lineal, con grandes deformaciones, hiperelástico, no-homogéneo y ortótropico. A la hora de analizar los resultados logrados y compararlos con los resultados obtenidos por otros autores no es posible establecer una comparación debido a los diferentes métodos de ensayo empleados por distintos autores y la dificultad en la experimentación en arterias humanas, solo es posible establecer zonas criticas en las cuales se presente algún tipo de enfermedad arterial.The social importance of the arterial illnesses motivates the interest in developing studies on the mechanical behavior of the arterial walls. The medical practice has pointed that these illnesses are strongly related with mechanical factors, such as states of deformation and tension as other related parameters. The present work offers a methodology to analyze the mechanical behavior of an artery (the aorta. This analysis uses a real geometry model that has been built based on medical images. In the formulation of the finite elements model the material has been considered with a no-linear behavior, with big deformations, hyperplasic, no-homogeneous and orthotropic. It is not possible to establish comparisons between the achieved results and the ones obtained by other authors. That is due to the different methods used by different authors and the difficulty in the

  9. Comparación bromatológica, microbiológica y sensorial de dos formulaciones de salchichas elaboradas con carne de conejo (Oryctolagus cuniculus)

    OpenAIRE

    José Igor Hleap Zapata; Yisell Vanessa Romero Erazo; Saúl Dussán Sarria

    2014-01-01

    En este estudio se evaluaron dos formulaciones diferentes de salchichas elaboradas con carne de conejo, utilizando como extendedores harina de chontaduro (Bactris gasipaes) y almidón modificado de maíz. Ambas formulaciones consistieron en 60% de carne de conejo, 12% de grasa de cerdo y 4% del respectivo extensor, el porcentaje restante correspondió a hielo y condimentos. Los análisis bromatológicos mostraron los contenidos siguientes (base seca): (1) en carne = 60.90% de proteína, 33.65% de...

  10. Eficacia de la membrana amniótica liofilizada como barrera en la regeneración ósea guiada en tibias de conejos

    OpenAIRE

    Jusef Yábar Condori; Yuri Castro Rodríguez; Sixto Grados Pomarino; Katia Medina Calderón; Emma Castro Gamero

    2014-01-01

    El presente estudio tuvo como objetivo determinar el efecto de la membrana amniótica liofilizada usada como barrera biológica en el proceso de regeneración ósea guiada en tibias de conejos. Materiales y métodos: se utilizaron 10 conejos de raza Nueva Zelanda de 2 a 2.5 Kg y de 4 a 6 meses de edad, en los cuales se crearon defectos circulares óseos de 4mm de diámetro en la región más inferior de las extremidades posteriores del conejo (tibias). Se formaron 2 grupos, el de control (no se colocó...

  11. Intradermo-reaccion en la Leishmaniosis Tegumentaria en el Perú: La prueba intradérmica con "leishmanina" en perros y conejos

    Directory of Open Access Journals (Sweden)

    German Battistini M

    1945-06-01

    Full Text Available Se ha probado el antígeno "leishmanina" en conejos inmunizados y perros inoculados con cultivos de Leishmania brasiliensis procedentes de casos de uta, obteniendo los siguientes resultados : 1. En los conejos la prueba intradérmica ha sido manifiesta entre las 24 y 48 horas, hasta con diluciones al 1/10 del antígeno. 2. Usando el antígeno sin diluír, en los perros también se obtuvo resultados positivos comparables a los obtenidos en los conejos, pero sólo durante los 20 días siguientes a la inoculación (con cultivos de leishmania. Una prueba llevada a cabo 10 días después, fué negativa.

  12. Origin of rhyolite by crustal melting and the nature of parental magmas in the Oligocene Conejos Formation, San Juan Mountains, Colorado, USA

    Science.gov (United States)

    Parker, D. F.; Ghosh, A.; Price, C. W.; Rinard, B. D.; Cullers, R. L.; Ren, M.

    2005-01-01

    Four closely spaced volcanoes (Summer Coon; Twin Mountains; Del Norte; Carnero Creek) form the east-central cluster of Conejos volcanic centers. These Conejos rocks range from high-K basaltic andesite to rhyolite, with andesite volumetrically the most abundant. Summer Coon and Twin Mountains are composite volcanoes. The Del Norte and Carnero Creek volcanoes are deeply eroded dacite shields. Rhyolite (10% of our Conejos analyses but a much smaller percentage by volume) is only known from Summer Coon and Twin Mountains volcanoes, although high-SiO 2 dacite occurs in the Del Norte volcano. The younger Hinsdale Formation contains a related series ranging from transitional basalt to high-K andesite; we use Hinsdale Formation analyses to represent Conejos parental magmas. Conejos and Hinsdale magmas evolved through AFC processes: Basalt, after interacting with lower crust, assimilated low K/Rb crust, similar in some ways to Taylor and McLennan (Taylor, S.R., and McLennan, S.M., 1985, The continental crust: its composition and evolution. Oxford, Blackwell Scientific.) model upper crust; main series basaltic andesite fractionated to high-K andesite; rhyolite was produced by melting of high K/Ba upper crustal rocks similar to granite gneiss known from inclusions and basement outcrops. Some rhyolite may have been back-mixed into fractionating andesite and dacite. Field evidence for assimilation includes sanidinite-facies, partially melted, gneiss blocks up to 1 m in diameter. Temperature estimates (1100-900 ° C) from two-pyroxene equilibria are consistent with this interpretation, as are the sparsely porphyritic nature of the most-evolved rhyolites and the absence of phenocrystic alkali feldspar. Our study supports the conclusions of previous workers on AFC processes in similar, but generally more mafic, Conejos magmas of the southeastern San Juan Mountains. Our results, however, emphasize the importance of crustal melting in the generation of Conejos rhyolite. We further

  13. Alargamiento de fémur con resección de periostio. Estudio experimental en el conejo

    OpenAIRE

    1994-01-01

    HIPÓTESIS DE TRABAJO:La integridad del periostio no es necesaria para conseguir la consolidación de un alargamiento.OBJETIVOS: 1. Demostrar que el alargamiento de fémur con resección del periostio puede consolidar en el conejo.2. Valorar si el adhesivo de fibrina a nivel del foco de elongación, con ausencia de periostio, endentece o no la consolidación del alargamiento.3. Establecer para medir la elongación, una correlación entre la clínica, la radiología y la ecografía.4. Encontrar una relac...

  14. Parcels and Land Ownership, Published in 2011, Conejos County Government.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Parcels and Land Ownership dataset as of 2011. The extent of these data is generally Conejos County, CO. This metadata was auto-generated through the Ramona...

  15. Estrategias de genética reversa aplicadas al vesivirus de conejo

    OpenAIRE

    García Manso, Alberto

    2016-01-01

    En el ámbito de la Virología, se denomina genética reversa al proceso de rescate de virus RNA de novo a partir de una copia del genoma viral en forma de cDNA. El trabajo recogido en esta memoria de tesis doctoral se ha dirigido a la obtención de un sistema de genética reversa para el vesivirus de conejo (RaV), uno de los pocos calicivirus capaz de ser propagado en cultivos celulares. Para ello, se han utilizado diferentes estrategias para expresar distintos clones de cDNA sintetizados. En ...

  16. 78 FR 45495 - Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation Management...

    Science.gov (United States)

    2013-07-29

    ... Forest Service Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation... statement. SUMMARY: The Conejos Peak Ranger District, Rio Grande National Forest, proposes to salvage timber... comments-rockv-mountain-rio-qrande-conejos-peak@fs.fed.us , or via facsimile to 719-852-6250, with...

  17. Ecocardiografía bidimensional normal en conejos neozelandeses blancos Normal two-dimensional echocardiography in new zewland white rabbits

    Directory of Open Access Journals (Sweden)

    P Chiaramonte

    2010-12-01

    Full Text Available Los autores describen las posiciones de las ventanas ecocardiográficas paraesternal derecha e izquierda, subxifoidea y subcostal izquierda, los aspectos anatómicos de los ecotomogramas de referencia en cada una de las ventanas estudiadas y presentan los valores medios obtenidos de los distintos accidentes e índices ecocardiográficos medidos en 38 conejos neozelandeses blancos. Los valores promedios obtenidos fueron los siguientes: espesor del septum interventricular en sístole (ESIVs: 2,9 mm ± 0,53 mm; espesor del septum interventricular en diástole (ESIVd: 4,41 mm ± 1,12 mm; diámetro sistólico del ventrículo izquierdo (DSVI: 15,76 mm ± 1,77 mm; diámetro diastólico del ventrículo izquierdo (DDVI:11,14 mm ± 1,73 mm; espesor de la pared libre del ventrículo izquierdo en sístole (EPLVId: 3,59 mm ± 0,54 mm; espesor de la pared libre del ventrículo izquierdo en diástole (EPLVIs: 4,53 mm ± 0,71 mm; fracción de acortamiento (FA%: 29,72 % ± 5,79 %; fracción de eyección (FE%: 64,09 % ± 8,61 %; diámetro aórtico a nivel de la base cardíaca (DAo: 8,87 mm ± 1,21 mm; diámetro del atrio izquierdo a nivel de la base cardíaca (DAi: 10,61 mm ± 1,28 mm; Relación atrio izquierdo y aorta en la base cardíaca (Ai:Ao: 1,21± 0,21; separación septal del punto E (SSPE: 2,18 mm ± 0,6 mm y excursión del anillo mitral (EAM: 5,61 mm ± 0,83 mm.Authors describe the position of the right and left parasternal, subxifoid and left subcostal echocardiographic windows, the anatomical aspects of the reference echotomograms of the studied windows, and present the obtained mean values of the different echocardiographic accidents and indexes in 38 New Zealand rabbits. The obtained means values were: interventricular septal thickness in systole (IVSTs: 2.95 mm ± 0.53 mm; interventricular septal thickness in diastole (IVSTd: 4.41 mm ± 1.12 mm; left ventricular systolic diameter (LVSD: 15.76 mm ± 1.77 mm; left ventricular diastolic diameter (LVDD

  18. Morus alba o Hibiscus rosa-sinensis como sustituto parcial de soya en dietas integrales para conejos

    Directory of Open Access Journals (Sweden)

    P. E. Lara

    2012-01-01

    Full Text Available Los conejos pueden aprovechar los nutrientes contenidos en los forrajes y subproductos agrícolas eficientemente gracias a la fermentación cecal y a la cecotrofía. Los objetivos del presente trabajo fueron: evaluar la tasa de crecimiento y el rendimiento de la canal en conejos alimentados con minibloques de harina de morera (Morus alba o tulipán (Hibiscus rosa-sinensis en sustitución parcial de pasta de soya; y determinar el consumo y digestibilidad de la dieta. Para esto, se utilizaron 18 conejos de 30 días de edad, distribuidos al azar en tres dietas experimentales (n=6, ac (alimento convencional, mbm (minibloque con 30% de morera y, mbt (minibloque con 27% de tulipán, durante nueve semanas. La ganancia diaria y el rendimiento en canal fue mejor (p0.10 en los tres grupos. Es factible sustituir parcialmente la proteína de la soya por harina de hojas de morera o tulipán, aunque presentan una menor respuesta productiva con respecto a la alimentación convencional.

  19. comparativo de tabletas de liberación controlada en conejos.

    Directory of Open Access Journals (Sweden)

    A Lagarto

    2008-01-01

    Full Text Available El objetivo del presente trabajo fue evaluar el potencial irritante gástrico de una formulación nacional de diclofenaco de sodio de liberación controlada comparativamente con un producto de importación y con una formulación recubierta con Sucralfato, mediante un ensayo agudo y otro a dosis repetidas en conejos Nueva Zelanda tratados con una dosis de 59 mg/kg por vía oral. Las tabletas de diclofenaco formulación nacional produjeron irritación gástrica ligera en el ensayo agudo, la cual fue similar a la producida con diclofenco importado y diclofenaco recubierto con sucralfato. La administración de diclofenaco formulación nacional durante 5 días en conejos produjo irritación gástrica, observándose erosión sobre la mucosa gástrica similar a la observada con la administración de diclofenaco importado. Los efectos sobre la mucosa gástrica y duodenal producidos por ambas formulaciones de diclofenaco fueron similares en el ensayo agudo y a dosis repetidas siendo factible el empleo de la formulación nacional en ensayos clínicos.

  20. PERITÔNIO DE BOVINO COMO BANDAGEM EM QUEIMADURAS CUTÂNEAS EXPERIMENTAIS EM COELHOS BOVINE PERITONEUM AS BANDAGE FOR FULL-THICKNESS CUTANEOUS BURNS IN RABBITS Peritoneo de los bóvidos como vendaje para las quemaduras cutáneas del lleno-grueso en conejos

    Directory of Open Access Journals (Sweden)

    Louisiane de Carvalho Nunes

    2009-09-01

    group. All wounds were involved by crepe gauze bandage and changed everyday and evaluation on 3, 7, 14 and 21 days of postoperative period. The bovine peritoneum bandage came off from wounds in 20 day of postoperative period, in average. xenogenic bandage in cutaneous burnings in rabbits causes absence of exudations and occlusion of the wound and formation of a scar organized with less intensity granulation tissue.

    KEY WORDS: Biological membrane, healing, skin, wounds.
    Una evaluación clínica e histopathological de la reparación cutánea de las quemaduras del lleno-grueso en conejos en la presencia de las preparaciones de herida del peritoneo de los bóvidos preservadas en el glicerol el 98% fue conducida. Dos áreas de los 2,5cm del diámetro, los 4cm equidistantes, en superficies torácicas dorsales derechas e izquierdas fueron delimitadas en dieciséis animales. Las áreas de la piel fueron quitadas hasta la exposición de la faja muscular. La faja y los bordes de la herida eran cauterized con eletrocautery. En las heridas en el derecho, el fragmento del peritoneo de los bóvidos conservado en la glicerina el 98% bajo wih humedecido gasa el 0.9% que la solución fisiological era heridas aplicadas (del grup tratado en el lado izquierdo fue irrigado con destilled el agua (grup del control. Todas las heridas fueron implicadas por el vendaje de la gasa del crepe y cambiaron diario y la evaluación en 3, 7, 14 y 21 días del período postoperatorio. El bandagem del peritonieum de los bóvidos vino apagado de heridas en el día 20 del período posoperative, en el vendaje xenogenic medio en burnings cutáneos en la ausencia de las causas de los conejos de exsudations y la obstrucción de la herida y la formación de una cicatriz organizada con menos tejido fino de la granulación de la intensidad.

  1. Variación de la concentración sanguínea del colesterol total y de las lipoproteínas en conejos hembras mantenidas a baja temperatura Change of the blood cholesterol and lipoproteins concentration in female rabbits maintained at low temperature

    Directory of Open Access Journals (Sweden)

    A. López-Ortega

    2000-01-01

    Full Text Available En la adaptación a la baja temperatura el metabolismo lipídico está involucrado como mecanismo generador de energía, especialmente por estimulación de la lipolisis en el tejido adiposo. Poco se conoce de la participación del colesterol circulante y de las lipoproteínas de baja y de alta densidad. Esta investigación tuvo como objetivo determinar el efecto de la mantención a baja temperatura por tiempo prolongado, sobre la concentración sanguínea de colesterol, LDL y HDL, en conejos hembras y su posible contribución al metabolismo energético. Con este objetivo se utilizaron 12 conejos NZW hembras adultas con un peso de 1,7 ± 0,2 Kg distribuidas en jaulas individuales bajo ciclos de luz de 12 h y con un aporte diario de 100 g de conejarina. El grupo control se mantuvo a temperatura ambiente (27 ± 2C y el grupo experimental se colocó a 5 ± 1C en un cuarto refrigerado. A los, 0, 30 y 60 días se obtuvo, por punción cardíaca, una muestra de sangre y en el plasma se determinó por método enzimático mediante kit Wiener Lab, la concentración de colesterol total, HDL-col y LDL-col. Los valores quedaron expresados en mg/dl y su análisis estadístico se realizó por el test de Student y un pIn the adaptive process to low temperature the lipidic metabolism is involved in energy production specially by stimulating lipolysis in the adipose tissue (AT however, little is known about the participation of circulating cholesterol, low (LDL and high density (HDL. This study was aimed to determine the effect of the prolonged exposure to low temperature on blood concentration of the above components and their possible contribution to the energetic metabolism in female rabbits. Twelve adult female NZW rabbits weighing 1.74 ± 0.18 Kg kept in separated cages under 12h light cycles and daily fed with 100g of commercial pellets were used. The control group was maintained at room temperature (27 ± 2C and the experimental group at 5°C ± 1°C in a

  2. Alimento balanceado-forraje verde idropónico en la alimentación de conejos criollos (oryctolagus cuniculus (Food green balance-forage hydroponic in the feeding of creole rabbits (oryctolagus cuniculus

    Directory of Open Access Journals (Sweden)

    José Rubén Nava Noriega; Juan Nava Zavaleta;

    2005-07-01

    Full Text Available La producción de forraje verde hidropónico (FVH se lleva a cabo en espacios reducidos con diferentes especies vegetales y condiciones hostiles, para alimentar diferentes especies de animales domésticos, equinos, bovinos, caprinos y conejos. El objetivo este trabajo fue valorar 9 proporciones de FVH-Alimento balanceado (AB y ambos por separado como dietas para alimentación de conejos machos criollos Oryctolagus cuniculus. El FVH se produjo con semillas de trigo Triticum aestivum, desinfectadas con hipoclorito de sodio al 5% y escarificadas por 24 horas con agua corriente; se transfirieron a charolas y se llevaron al invernadero, al inicio se regaron con agua corriente, luego con solución nutritiva durante 14 días. El experimento fue completamente al azar (CA con 11 tratamientos, proporciones FVH-AB, FVH y AB por separado, con 3 repeticiones. El experimento duró siete semanas y se registró el peso de los conejos una vez por semana, los datos se procesaron por análisis de varianza (P=0.05 con la prueba de medias de Tukey. Los resultados del peso de los conejos fueron significativos a partir de la cuarta semana, desde la proporción 60% de FVH + 40% de AB hasta AB solo, tratamientos del 3 al 11, con 100% FVH y 90% FVH + 10% AB. Se encontró semejanzas y diferencias con otros autores que han utilizado proporciones FVH + AB para conejos. Se concluye, que a partir de la proporción 60% FVH + 40 % AB puede ser utilizada en la alimentación de conejos criollos (Oryctolagus cuniculus con resultados de ganancia de peso similares a los obtenidos cuando se utiliza de 100% AB.

  3. Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duodenum El Trolox reduce el efecto del etanol sobre las contracciones inducidas a la acetilcolina y el estrés oxidativo en duodeno aislado de conejo

    Directory of Open Access Journals (Sweden)

    Diego S. Fagundes

    2011-08-01

    Full Text Available Trolox is a hydrophilic analogue of vitamin E and a free radical scavenger. Ethanol diminishes the amplitude of spontaneous contractions and acetylcholine (ACh-induced contractions in rabbit duodenum. The aim of this work was to study the effect of Trolox on the alterations induced by ethanol on contractility and lipid peroxidation in the duodenum. The duodenal contractility studies in vitro were carried out in an organ bath and the levels of malondialdehyde and 4-hydroxyalkenals (MDA+4-HAD were measured by spectrophotometry. Trolox increased the reduction induced by ethanol on the amplitude of spontaneous contractions in longitudinal muscle but not in circular muscle. Trolox 4 mM decreased the effects of ethanol on ACh-induced contractions and on MDA+4-HDA concentrations. We conclude that Trolox might prevent oxidative stress induced by ethanol in the duodenum.El Trolox es un análogo hidrofílico de la vitamina E y un agente que secuestra radicales libres. El etanol disminuye la amplitud de las contracciones espontáneas y las contracciones inducidas a la acetilcolina en el duodeno de conejo. El objetivo de este trabajo era estudiar el efecto del Trolox en las alteraciones inducidas por el etanol sobre la contractilidad y la peroxidación lipídica en el duodeno. Los estudios de contractilidad duodenal in vitro se realizaron en un baño de órganos y los niveles de MDA+4-HDA se midieron por espectofotometría. El Trolox aumentó la reducción inducida por el etanol sobre la amplitud de las contracciones espontáneas en el músculo longitudinal pero no en el músculo circular de duodeno. El Trolox 4 mM redujo los efectos del etanol sobre las contracciones inducidas a la acetilcolina y sobre las concentraciones de MDA+4-HDA. Se concluye que el Trolox podría prevenir el estrés oxidativo inducido por el etanol en el duodeno.

  4. Bordetella bronchiseptica como un riesgo importante de salud publica. Estudio clínico patológico en conejos

    OpenAIRE

    Valladares-Carranza B.; Ortega-Santana C; Velazquez-Ordoñez V; Zamora-Espinosa J.L.; Peñuelas-Rivas C.G.; Castro-Maruri J.; Talavera-Rojas M.; Alonso-Fresan M.U.; Zaragoza-Bastida A.

    2011-01-01

    B. bronchiseptica es reconocida como un patógeno primario inicial del tracto respiratorio en animales domésticos, puede provocar tos de las perreras (perro), respiración ruidosa (en conejos) y rinitis atrófica (en el cerdo). Conel objeto de enfatizar la importancia que representa en salud pública la infección ocasionada por Bordetella bronchiseptica se presenta un caso clínico ocurrido en una unidad de producción cúnicola en el Estado de México, México. Por la mortalidad observada en la gran...

  5. Respuesta productiva de conejos alimentados con forraje verde hidropónico de avena, como reemplazo parcial de concentrado comercial

    Directory of Open Access Journals (Sweden)

    Francisco Fabián Fuentes Carmona

    2011-04-01

    Full Text Available La respuesta productiva de conejos raza californiana alimentados con forraje verde hidropónico (FVH de avena como reemplazo parcial de concentrado comercial (CC, fue evaluada en condiciones de desierto en el norte de Chile. Se establecieron cinco tratamientos de alimentación, equivalentes a 0, 25, 50, 75 y 100% de reemplazo de la dieta diaria con FVH, el cual fue cosechado y utilizado directamente diez días después de la siembra. Cuarenta y cinco conejos destetados a los 31 días fueron evaluados en un diseño completamente al azar hasta alcanzar un peso de sacrificio de 2 kg de peso vivo. La calidad del FVH de avena fue considerada como buena, presentando similar valor nutritivo que el CC. Las variables evaluadas y sus respectivos rangos fueron: consumo de materia seca promedio (59.17 - 104.73 g/día, ganancia de peso vivo promedio (16.35 - 29.10 g/animal por día, conversión alimenticia promedio (3.31 - 3.93 kg MS/kg PV, tiempo de peso vivo a sacrificio (53 - 91 días, peso vivo final (1430 - 2044 g/animal, peso de la canal (1235 - 1385 g/animal y rendimiento de la canal (59.19 - 62.25%. El reemplazo de hasta 50% de la dieta base con FVH de avena no afectó significativamente (P < 0.05 el consumo de alimento, tiempo de peso vivo a sacrificio, peso vivo final y rendimiento de la canal, haciendo posible su uso como recurso forrajero alternativo en la alimentación de conejos en etapa de engorde en condiciones de desierto.

  6. Respuesta productiva de conejos alimentados con forraje verde hidropónico de avena, como reemplazo parcial de concentrado comercial

    Directory of Open Access Journals (Sweden)

    Poblete Pérez Cecilia Eva

    2011-06-01

    Full Text Available La respuesta productiva de conejos raza californiana alimentados con forraje verde hidropónico (FVH deavena como reemplazo parcial de concentrado comercial (CC, fue evaluada en condiciones de desiertoen el norte de Chile. Se establecieron cinco tratamientos de alimentación, equivalentes a 0, 25, 50, 75 y100% de reemplazo de la dieta diaria con FVH, el cual fue cosechado y utilizado directamente diez díasdespués de la siembra. Cuarenta y cinco conejos destetados a los 31 días fueron evaluados en un diseñocompletamente al azar hasta alcanzar un peso de sacrificio de 2 kg de peso vivo. La calidad del FVH deavena fue considerada como buena, presentando similar valor nutritivo que el CC. Las variables evaluadasy sus respectivos rangos fueron: consumo de materia seca promedio (59.17 - 104.73 g/día, gananciade peso vivo promedio (16.35 - 29.10 g/animal por día, conversión alimenticia promedio (3.31 - 3.93 kgMS/kg PV, tiempo de peso vivo a sacrificio (53 - 91 días, peso vivo final (1430 - 2044 g/animal, pesode la canal (1235 - 1385 g/animal y rendimiento de la canal (59.19 - 62.25%. El reemplazo de hasta50% de la dieta base con FVH de avena no afectó significativamente (P ≤ 0.05 el consumo de alimento,tiempo de peso vivo a sacrificio, peso vivo final y rendimiento de la canal, haciendo posible su uso comorecurso forrajero alternativo en la alimentación de conejos en etapa de engorde en condiciones de desierto.

  7. Caracterización de las fracturas antrópicas y sus tipologías en huesos de conejo procedentes de los niveles gravetienses de la Cova de les Cendres (Alicante

    Directory of Open Access Journals (Sweden)

    M. Pérez Ripoll

    2005-01-01

    Full Text Available El consumo humano de conejos en los yacimientos valencianos del Paleolítico superior fue importante. El aspecto más llamativo fue el consumo intensivo de sus recursos alimenticios. Los conejos eran descarnados y sus huesos sistematicamente mordidos y mordisqueados para obtener pequeños trozos de carne pegados al hueso y pequeñas cantidades de médula. La morfología de las mordeduras están avaladas por la experimentación. Además, se comparan las morfologias de huesos mordidos por humanos y carnívoros. Se ofrecen los morfotipos de fracturas de cada hueso del esqueleto del nivel Gravetiense de La Cova de Les Cendres (Alicante.

  8. Profilaxis de los puentes óseos fisarios mediante interposición de injerto autólogo de periostio. Estudio experimental en conejos

    OpenAIRE

    1994-01-01

    Se ha realizado un trabajo experimental sobre la profilaxis de los puentes óseos epifisometafisarios mediante la interposición de injerto autólogo de periostio, planteando los siguientes objetivos: 1) Conseguir una barrera epifisometafisaria que impida la comunicación de los vasos epifisarios y metafisarios y 2) Estudiar la capacidad condrogénica del periostio. Se han utilizado 48 conejos, distribuidos en dos Series de cuatro Grupos cada una, según el momento del sacrificio a l...

  9. Estudio comparativo del uso de la matriz ósea desmineralizada de origen humana y de la poliuretana derivada del aceite de mamona sobre el proceso de regeneración ósea: Estudio histométrico en calota de conejos A comparative study on the use of demineralized bone matrix of human origin and polyurethane derived from castor oil in bone regeneration processes: A histometric study on rabbit calvaria

    Directory of Open Access Journals (Sweden)

    J. Rodrigues Laureano Filho

    2007-08-01

    Full Text Available Objetivo. Analizar histométricamente el efecto de la matriz ósea desmineralizada de origen humana y de la resina poliuretana derivada del aceite de mamona, sobre el proceso de regeneración ósea. Diseño del estudio: fueron utilizados 24 conejos y en cada calota craniana fueron preparadas dos cavidades quirúrgicas, siendo una a cada lado de la sutura parietal. Los animales fueron divididos en dos grupos. En el grupo I la cavidad experimental (lado derecho fue rellenada con la poliuretana derivada del aceite de mamona, mientras que en el grupo II la cavidad experimental fue rellenada con la matriz ósea desmineralizada de origen humano. Las cavidades de control fueron rellenadas solo con la sangre del animal. Los animales fueron sacrificados en los períodos postoperatorios de 04, 07 y 15 semanas. Resultados. El análisis estadístico, realizado en base de los datos de la histometría, mostró una mayor neoformación ósea de los grupos I y II en relación al grupo control, no existiendo diferencia estadística cuando los grupos experimentales fueron comparados. Conclusiones. El uso de poliuretana derivada del aceite de mamona y matriz ósea desmineralizada de origen humano mejoran el proceso de regeneración cuando lo comparamos a la regeneración ósea normal resultando que entre ambos materiales tuvieron un comportamiento similar sin diferencias estadísticas significantes entre sí.Objective. The present study was aimed at carrying out a histological and histometric analysis on the effect of human demineralized bone matrix and a polyurethane resin, derived of the castor bean oil, on the bone regeneration process. Design: For this, 24 rabbits were used and in each calvarium two surgical bone defect were prepared, one on the right side and another on the left side of the parietal suture. The animals were divided into two groups. In group I the experimental defect (right side was filled with polyurethane derived from oil of the castor oil

  10. [Curriculum vitae aortae].

    Science.gov (United States)

    Solberg, S

    1998-12-10

    The Greek word aorta means lifter. The vessel was so termed because Aristotle, who first described it, assumed that the heart was lifted by/hanging in aorta. Leonardo da Vinci described the detailed anatomy of aorta. During the 17th century our present understanding of the aorta and the circulation of blood took form due to the descriptions given by William Harvey. The first known operation for abdominal aortic aneurysm was performed in London in 1817 by Sir Astley Cooper who ligated the infrarenal aorta above the aneurysm. Puncture with needles and application of electricity were later tried in order to induce thromboses in the aneurysm. In 1948 Albert Einstein was operated with wrapping of his abdominal aneurysm with cellophane. In 1955 he suffered rupture and died after having refused operation. In 1951 the first successful operation for abdominal aortic aneurysm was performed in Paris by Charles Dubost. With slight modifications, the same operative technique is used today.

  11. Rabbit IgG antibodies against Phospholipase A2 from Crotalus durissus terrificus neutralize the lethal activity of the venom Los anticuerpos IgG de conejos anti-fosfolipasa A2 de Crotalus durissus terrificus neutralizan la actividad letal del veneno

    Directory of Open Access Journals (Sweden)

    Juan P. Rodríguez

    2006-12-01

    Full Text Available Crotalus durissus terrificus (C.d.t. (South American rattlesnake venom possesses myotoxic and neurotoxic activities, both of which are also expressed by crotoxin, the principal toxin of this venom. Crotoxin contains a basic phospholipase A2 (PLA2 and a non toxic acidic protein, crotapotin. We have produced and investigated the ability of IgG antibodies raised in rabbits against PLA2 to neutralize the lethality of the whole venom. PLA2 was isolated by gel filtration chromatography (Sephadex G-75. Specific antibodies were obtained by subcutaneous and intramuscular inoculation of PLA2 (700 µg with Freund adjuvant. Groups of six mice (20 + 2 g were inoculated with 0.5 ml i.p. of C. d. t. venom (4 µg or a mixture of venom that had been preincubated with the desired volume of IgG antibodies. Mortality, recorded 24 and 48 h after inoculation, showed that IgG anti-PLA2 were more effective than anticrotalic serum in neutralizing the lethal activity. These results demonstrate that it could be possible to obtain an anti-venom made by specific antibodies with a high level of protection against the lethal component of C.d.t. venom, and/or the inclusion of these antibodies as a supplement in heterologous anti-venoms.El veneno de Crotalus durissus terrificus (C.d.t. (Cascabel de Sud América posee actividad miotóxica y neurotóxica, actividades que también exhibe el complejo crotoxina, principal componente tóxico de este veneno. El complejo crotoxina está constituido por una fosfolipasa A2 básica (PLA2 y una proteína acídica no tóxica, el crotapotín. En este trabajo se estudió la capacidad neutralizante de anticuerpos IgG anti-PLA2 sobre la letalidad inducida por el veneno entero. El antígeno PLA2, fue aislado por cromatografía de filtración en gel (Sephadex G-75. Se inocularon conejos machos por vía subcutánea e intramuscular, con 700 µg de PLA2 y adyuvante para la obtención de anticuerpos específicos. La capacidad neutralizante del

  12. Observación de la reacción tisular del precinto comercial de poliamida empleado como método de ligadura en pedículo renal y ute rino en conejos Observation of tissular reaction of commercial polyamide seal used as a method of bond in renal and uterine pedicle in rabbits

    Directory of Open Access Journals (Sweden)

    R Rovere

    2007-01-01

    Full Text Available La ligadura constituye el método más corriente para el control local y permanente de las hemorragias. Ha sido usada por más de 4.000 años a través del empleo de distintos materiales, desde el lino, la seda, intestino de oveja o fibras de tendón, hasta los actuales materiales sintéticos, absorbibles (polioglactin 910 y polidioxanona o no absorbibles (polipropileno, poliéster y poliamida. Las grapas y clips vasculares pueden también ser empleados para la hemostasia permanente, los cuales permiten una buena oclusión de los pedículos vasculares, pero lamentablemente su elevado costo limita la utilización en la cirugía veterinaria. Se evaluó la respuesta tisular provocada en los pedículos vasculares sometidos a ligadura con precintos de poliamida en conejos. En seis animales machos se realizó la nefrectomía y se ligó el pedículo con un precinto de poliamida; en los seis restantes se procedió a la ovario-histerectomía con la colocación de un precinto a nivel cervical. La hemostasia provista por el implante se obtiene en forma inmediata y segura tras su aplicación. Las observaciones macroscópicas y los resultados microscópicos en los animales intervenidos muestran que la reacción tisular fue mínima. En los estudios histopatológicos no se observaron necrosis tisular ni un importante grado de inflamación, como tampoco signos de infección. El precinto comercial de poliamida se presenta como una técnica de fácil aplicación, segura, con mínima reacción tisular y de bajo costo para ser empleado en la ligadura de pedículos vasculares en las intervenciones quirúrgicas en la práctica veterinaria.Ligation is the most common localized and permanent method for the control of haemorrhages. It has been used for more than 4000 years through the employment of different materials, from linen, silk, sheep intestine or tendon fibers until the current use of synthetic materials, absorbables (polyglactine and polydioxanone or non

  13. Eficacia de la membrana amniótica liofilizada como barrera en la regeneración ósea guiada en tibias de conejos

    Directory of Open Access Journals (Sweden)

    Jusef Yábar Condori

    2014-07-01

    Full Text Available El presente estudio tuvo como objetivo determinar el efecto de la membrana amniótica liofilizada usada como barrera biológica en el proceso de regeneración ósea guiada en tibias de conejos. Materiales y métodos: se utilizaron 10 conejos de raza Nueva Zelanda de 2 a 2.5 Kg y de 4 a 6 meses de edad, en los cuales se crearon defectos circulares óseos de 4mm de diámetro en la región más inferior de las extremidades posteriores del conejo (tibias. Se formaron 2 grupos, el de control (no se colocó membrana y el experimental (se colocó membrana amniótica liofilizada como barrera. Los animales fueron sacrificados a las 6 semanas de la cirugía, realizándose un análisis clínico,  radiológico e histológico de la zona donde se crearon los defectos óseos. Resultados: clínicamente se observó ausencia de reacción inflamatoria (100% y de procesos infecciosos (100%, al examen histológico un 87.5% de las muestras del grupo de estudio mostró presencia de hueso maduro compacto mientras que en el grupo control se reportó un 100% de ausencia del mismo. Conclusión: la regeneración ósea fue significativamente mayor en los defectos cubiertos con membrana amniótica liofilizada comparada con las muestras del grupo control.

  14. Anestesia general en el conejo (General Anaesthesia in rabbit)

    OpenAIRE

    Bimonte Patetta, Diego:; Rodríguez Nieves, Carlos:; de Casas, Luis; Vedovatti Manzoni,Ernesto:

    2007-01-01

    Los autores realizan una revisión de las técnicas utilizadas para la anestesia en conejos (Oryctolagus cuniculus), relatando la xperiencia acumulada en 10 años de anestesia en esta especie bajo distintos regímenes: anestesia inyectable, inhalatoria, en uso tanto clínico como en la investigación. Se hace una descripción de las técnicas anestésicas utilizadas así como los procedimientos empleados tanto en anestesia inyectable como en inhalatoria en esta especie,así como la comparación de una d...

  15. Identification of the method to quantify soluble fibre and the effect of the source of fibre on the ileal and faecal digestibility of soluble and insoluble fibre in rabbits = Identificación del método para cuantificar la fibra soluble y el efecto de la fuente de fibra en la digestibilidad ileal y fecal de la fibra soluble e insoluble en conejos

    OpenAIRE

    Abad Guamán, Rodrigo Medardo

    2015-01-01

    La presente tesis constituye un avance en el estudio de los métodos para cuantificar la fibra soluble y los efectos de las fracciones de fibra y las fuentes de fibra sobre la digestión de las diferentes fracciones de fibra (soluble e insoluble) en el conejo. Hay un efecto positivo de la fibra soluble sobre la salud intestinal de los conejos y, por ende, una reducción de la mortalidad en animales destetados. Pese a esto, no está claro si estos efectos se deben específicamente a la fracción sol...

  16. Evaluación del riesgo de ruptura de aneurismas de aorta abdominal personalizados mediante factores biomecánicos/Patient-specific abdominal aortic aneurysms rupture risk assessment by means of biomechanical factors

    Directory of Open Access Journals (Sweden)

    Ariel Zúñiga‐Reyes

    2014-05-01

    Full Text Available El Aneurisma de Aorta Abdominal es la dilatación localizada, irreversible y progresiva que experimenta la pared aortica. Esta patología ha sido reconocida como un importante problema de salud, puesto que su ruptura está asociada mayormente a consecuencias fatales. La falta de criterios fiables, respecto a los actualmente utilizados, para la evaluación del riesgo de ruptura, constituye un inconveniente en la gestión clínica de la enfermedad. El presente trabajo tiene como objetivo evaluar el riesgo de ruptura de Aneurismas de Aorta Abdominal, mediante indicadores numéricos, como es previsto por el enfoque biomecánico. Fueron utilizadas técnicas de modelación por elementos finitos para determinar el comportamiento del flujo sanguíneo y el estado tensional de la pared arterial. Los resultados mostraron que ninguno de los aneurismas analizados presenta riesgo de ruptura elevado y que la evaluación del riesgo de ruptura mediante índices numéricos, es un camino viable para prever la ruptura de un aneurisma específico.Palabras claves: aneurisma de aorta abdominal, factores biomecánicos, interacción fluido-sólido, riesgo de ruptura.______________________________________________________________________________AbstractAbdominal Aortic Aneurysm is a localized, progressive and permanent dilation of the infra-renal aorta.AAA has increasingly been recognized as an important health problem in the last decades. The AAA rupture is mostly associated with fatal consequences. The lack of more reliable criteria for rupture riskassessing, results in a problem in the clinical management of the disease. This paper aims to assess the rupture risk of abdominal aortic aneurysms by means of numerical indexes, as envisaged by the biomechanical approach. Finite Volume Techniques were used to determine the blood flow behavior within aneurysmatic sac and the structural state of the arterial wall. The results showed that none of the assessed aneurysms is at

  17. Toxicología aguda del D-004 en conejos

    Directory of Open Access Journals (Sweden)

    Ariadne Gutiérrez Martínez

    2007-01-01

    entre los grupos tratados y el control en ninguno de los sexos. El D-004 presentó una toxicidad intrínseca baja, al mostrar una DL50 superior a los 2 000 mg/kg de peso corporal, dosis con la que no se evidenciaron signos indicativos de toxicidad en ninguno de los sexos, por lo que su toxicidad se puede declarar como no clasificable según el método de las clases de toxicidad aguda.

  18. Applications of satellite snow cover in computerized short-term streamflow forecasting. [Conejos River, Colorado

    Science.gov (United States)

    Leaf, C. F.

    1975-01-01

    A procedure is described whereby the correlation between: (1) satellite derived snow-cover depletion and (2) residual snowpack water equivalent, can be used to update computerized residual flow forecasts for the Conejos River in southern Colorado.

  19. Coarctation of the Aorta

    Science.gov (United States)

    ... of the aorta (aneurysm) Aortic rupture or tear (dissection) Premature coronary artery disease — narrowing of the blood ... have a higher risk of aortic rupture, aortic dissection or other complications during pregnancy and delivery. Doctors ...

  20. Autoficción y trabajo de memoria en La casa de los conejos de Laura Alcoba

    Directory of Open Access Journals (Sweden)

    Bruno Ragazzi

    2014-02-01

    Full Text Available Este artículo se propone indagar acerca de las representaciones discursivas en el campo de memoria que se presentan en La casa de los conejos de Laura Alcoba. Se cree que la elección del género de la autoficción es una herramienta genérica que permite descubrir nuevas narrativas mnémicas en torno al enfrentamiento desigual entre Montoneros y las fuerzas represivas de la derecha. Estas novedosas maneras de ver el pasado se vinculan con lo que Ricoeur ha denominado “trabajo de memoria”, una elaboración terapéutica sobre el recuerdo que permite a un pueblo abrirse hacia la esperanza y el perdón.

  1. Anestesia general en el conejo (General Anaesthesia in rabbit

    Directory of Open Access Journals (Sweden)

    Bimonte Patetta, Diego:

    2007-07-01

    Full Text Available Los autores realizan una revisión de las técnicas utilizadas para la anestesia en conejos (Oryctolagus cuniculus, relatando la xperiencia acumulada en 10 años de anestesia en esta especie bajo distintos regímenes: anestesia inyectable, inhalatoria, en uso tanto clínico como en la investigación. Se hace una descripción de las técnicas anestésicas utilizadas así como los procedimientos empleados tanto en anestesia inyectable como en inhalatoria en esta especie,así como la comparación de una de las técnicas de anestesia recomendada y la utilizada como base en nuestro quirófano.

  2. EVALUACIÓN DE CUATRO NIVELES DE MORERA (Morus alba EN ENGORDE DE CONEJO BAJO NORMATIVA ORGÁNICA

    Directory of Open Access Journals (Sweden)

    David Mora-Valverde

    2012-01-01

    Full Text Available El objetivo de este estudio fue evaluar dietas para conejos cuyo componente principal fuese la morera. Se desarrolló una evaluación nutricional en la provincia de Cartago, Costa Rica, bajo un sistema de manejo y alimentación acordes con la normativa de producción orgánica; utilizando un sistema de alojamiento diferenciado. Se evaluaron cuatro niveles de inclusión de harina de morera dentro de la ración completa; D1: 45%; D2: 55%; D3: 65% y D4: 75%. Se observaron ganancias de peso diaria en el orden de 17,65 g/d (promedio general. Las dietas D1 y D2, presentaron los parámetros de crecimiento más altos respecto a las dietas con niveles de 65% (D3 y 75 % (D4 de inclusión. Las ganancias diarias de peso obtenidas presentaron valores de D1: 17,26 g/d, D2: 21,57 g/d, D3: 14,77 g/d y D4: 17,00 g/d. En relación a la conversión alimenticia, los conejos de las dietas D1 y D2 fueron más eficientes en el uso del alimento para fines de crecimiento que los conejos de las dietas D3 y D4 (P<0,05. El costo de alimento total para llevar a los animales hasta peso de mercado para cada tratamiento fue D1: 2,26 US$/kg; D2: 2,17 US$/kg, D3: 2,49 US$/kg y D4: 2,44 US$/kg. Se estimó que el tiempo de engorde y de salida a mercado se prolongaría entre 2 a 3,5 veces con respecto a un periodo típico de engorde utilizando únicamente concentrados, existiendo un equilibrio respecto a la reducción en los costos de alimentación entre el 45 y 50%.

  3. Implantación de hidroxiapatita-lignina en canal medular de conejos: evaluación macroscópica y difractográfica

    Directory of Open Access Journals (Sweden)

    Mastoby Martínez M.

    2012-12-01

    Full Text Available Objetivo. Evaluar macroscópica y difractograficamente la respuesta ósea al compuesto hidroxiapatita–lignina implantado en canal medular tibial de conejos. Materiales y métodos. Se utilizaron 20 conejos de raza Nueva Zelanda, en cada uno, la tibia izquierda fue tratada con compuesto y la tibia derecha no fue, sirviendo como control. Se realizó una falla ósea de 4 mm de diámetro en la superficie lateral proximal tibial, hasta alcanzar el canal medular. Del compuesto, 1000 mg fueron ablandados con 10 gotas de solución salina utilizando parte de la masa para revestir la rosca del clavo intramedular de Schanz en acero F 138, de diámetro 2.5 mm para hueso cortical y la otra parte introducida en el canal medular con el auxilio de catéter calibre 16 y jeringa. El clavo revestido se introdujo al canal medular por la falla ósea. Los planos anatómicos fueron suturados. Lo mismo fue realizado en el control, sin utilización del compuesto. La evaluación macroscópica y difractográfica del contenido medular y del material que creció en las rocas de los clavos se hizo a los ocho, 30, 60, 90 y 120 días pos-cirugía. Resultados. Con cada fecha de evaluación la tendencia de la medula ósea en los tratados fue a regenerarse y la del compuesto a perder visibilidad, lo que se demostró con la difracción de rayos X, encontrándose tejido con cristalinidad compatible con el componente mineral del hueso. Conclusiones. El compuesto puede guiar la formación de hueso hasta el clavo intramedular sin afectar la regeneración de médula ósea.

  4. Influencia de la geometría de aneurismas de aorta abdominal en la dinámica del flujo sanguíneo y en su riesgo de ruptura

    Directory of Open Access Journals (Sweden)

    G. Vilalta

    2009-05-01

    Full Text Available La ruptura de aneurisma de aorta abdominal (AAA representa un evento clínico muy importante, con una tasa de mortalidad relativamente elevada. En un esfuerzo por aumentar la comprensión sobre este complejo fenómeno, en el presente trabajo se estudia la influencia de la geometría de los aneurismas de aorta abdominal en el riesgo de ruptura. Para esto se ha utilizado un modelo geométrico realista, obtenido por la transformación de imágenes 2D de tomografía computarizada (CT, sometido a un flujo pulsátil fisiológicamente realista, con el objetivo de evaluar e identificar las regiones donde ocurren las principales perturbaciones en los patrones de flujo, cómo ésta modifica los campos de velocidades y de tensiones hemodinámicas en el interior del saco aneurismático, así como la influencia de los diferentes factores biomécanicos relacionados con la geometría que caracterizan el aneurisma. Se presenta una explicación de las modificaciones de las estructuras vorticales y de la distribución de tensiones durante el ciclo cardíaco. Igualmente se determina un indicador numérico (Parámetro de Severidad que integra los 3 factores biomecánicos geométricos y que permite evaluar el riesgo de ruptura del aneurisma para un estado de desarrollo determinado. Los resultados confirman que la asimetría de los aneurismas de aorta abdominal es uno de los principales factores que influyen en su ruptura.The rupture of abdominal aortic aneurysm (AAA represents an important clinical event, with a relatively high mortality rate. In an effort to increase understanding about this complex phenomenon, this paper studies the influence of abdominal aortic aneurysms geometry on the risk of rupture. Patient specific AAA model, created by 2D reconstruction of computed tomography image, was used to identify regions of disturbed patterns flow and how it modifies the velocity field and hemodynamic stress on the inside of the aneurysmatic sac as well as the

  5. Composición bromatológica de la carne de conejos suplementados con mataratón y cachaza de palma aceitera

    Directory of Open Access Journals (Sweden)

    Auristela Malavé A.

    2013-08-01

    Full Text Available Objetivo. Evaluar comparativamente el efecto de la suplementación del alimento balanceado comercial (ABC con follaje de mataratón (Gliricidia sepium y cachaza de palma aceitera (Elaeis guineensis en la composición bromatológica de la carne de conejo. Materiales y métodos. Las muestras de carne estudiadas en el presente trabajo, provienen de una investigación previa con un diseño experimental de bloques al azar con tres tratamientos (dietas y tres repeticiones (bloques con muestreo de tres réplicas por repetición, donde se utilizaron 27 conejos machos mestizos durante el período postdestete divididos en tres tratamientos: uno control (T0, alimentados sólo con ABC, y dos suplementados con mataratón y cachaza de palma aceitera en proporciones de 30 y 10% (T1, y 10 y 30% (T2, respectivamente, a manera de comparar el efecto de las dietas en el valor nutricional. Resultados. Las muestras de carne provenientes de los diferentes animales en tratamiento, se evaluaron encontrando que la suplementación no afectó significativamente la composición bromatológica (p>0.05 para el contenido de humedad (70.77 a 72.42%, proteínas (19.08 a 20.34%, cenizas (1.53 a 1.68% y lípidos (6.48 a 7.23%; indicando que indistintamente de la dieta empleada, suplementando el ABC con mataratón/fibra de palma o no, las carnes de conejo obtenidas son nutricionalmente idénticas como alimento. Conclusiones. Con base en los resultados, se sugiere que el follaje de mataratón y la fibra de palma aceitera podrían constituir una alternativa como recursos agronómicos tropicales en la producción de carne de conejo para el consumo humano.

  6. Evaluación del kudzu Pueraria montana suplementado con dos fuentes de energía, en sorgo, harina de yuca y premezcla vitamínico-mineral en alimentación de conejos en la fase de engorde

    Directory of Open Access Journals (Sweden)

    Silva S. Liliana

    1991-12-01

    Full Text Available

    En el experimento se emplearon 63 conejos de la raza Nueva Zelanda blanca, distribuidos en un diseño completamente al azar con arreglo factorial de 2 x 3 + 1, con 7 tratamientos, 3 repeticiones. Los animales se alojaron en jaulas de 1.5 m x 0.75 m x 0.5 m. Se evaluaron las variables consumo de materia seca, ganancia de peso y conversión alimenticia. La mejor ganancia de peso (23.5 g y la menor conversión (3.3 se registraron en el tratamiento testigo. No se presentaron diferencias significativas en el consumo de materia seca.

    Kudzú Pueraria montana hay, supplemented with two energetic sources: sorghum and cassava in feeding rabbits. Sixthy three New Zeland rabbits were distributed in a Complete Random design with a factorial arrangement 2 x 3 + 1, usmg 7 treatments, 3 replicates unit. Rabbits were located in 1.5 m widht, 0.75 m length and 0.5 m height, cages. Dry rnatter consumption, widht gain and feed conversion were evaluated. The best daily weight gain (23.5 g and feed conversion (3.3 were recorded for control treatment. There were no significant differences in relation to dry matter consumption.

  7. Sustitución de alimento comercial por excretas en la dieta de conejos en crecimiento

    Directory of Open Access Journals (Sweden)

    S. P. Castillo-Rodríguez

    2007-01-01

    Full Text Available La presente investigación se llevó a cabo para evaluar el efecto de la sustitución de alimento comercial por una mezcla de excretas [gallinas, cerdos y vacas] sobre el crecimiento de conejos Nueva Zelanda. Se utilizaron 30 animales con un promedio de peso de 600 + 18.2 g, y edad de 35 días, los cuales se colocaron en jaulas individuales. Los tratamientos consistieron en la sustitución parcial del alimento comercial en niveles de 0, 15, 20, 25, 30 y 35%, con una mezcla de excretas (gallinaza, cerdaza y bovinaza. La prueba tuvo una duración de 42 días, el alimento y agua de bebida fueron ofrecidos ad libitum. Todos los días se pesó el alimento ofrecido y el rechazado; el peso de los animales se registró semanalmente. Las medias generales ± desviación estándar para ganancia de peso, consumo de alimento y digestibilidad aparente fueron 866 ± 129 g, 3.02 ± 0.35 kg y 64.0 ± 0.5%, respectivamente. La ganancia de peso, consumo de alimento y digestibilidad aparente fueron afectadas por el nivel de excretas en la ración (P 0.05, pero la digestibilidad aparente fue menor en los niveles de 30 y 35% de excretas. Se puede concluir que las excretas pueden ser usadas hasta en un 25% con resultados satisfactorios y sin efectos adversos sobre la ganancia de peso y la conversión alimenticia.

  8. Conejo Valley Unified School District Master Plan for an Educational Results Information System.

    Science.gov (United States)

    Maloney, Dorothy

    The Conejo Valley (CA) Unified School District Educational Results Information System (ERIS), a generalized District master program assessment plan to obtain results information for decision-makers at all levels, has been developed. This plan establishes guidelines, evaluates the current status of the use of educational results information and…

  9. Facts about Coarctation of the Aorta

    Science.gov (United States)

    ... Websites Information For... Media Policy Makers Facts about Coarctation of the Aorta Recommend on Facebook Tweet Share ... the body, is narrower than usual. What is Coarctation of the Aorta? Coarctation of the aorta is ...

  10. New systems of management to improve the health and welfare of rabbits in farm conditions = Nuevos sistemas de cría y manejo para mejorar la salud y bienestar de conejos de granja

    OpenAIRE

    Alfonso Carrillo, Clara

    2016-01-01

    El objetivo general de esta Tesis Doctoral fue evaluar nuevos sistemas de alojamiento y cría de conejos de granja, estudiando tanto parámetros comportamentales (experimento 1) como productivos y reproductivos (experimento 3). Además, se evaluaron diferentes técnicas de muestreo con el fin de optimizar el tiempo empleado para el estudio del comportamiento animal (experimento 2). En el experimento 1, se estudió el comportamiento de conejas alojadas en dos tipos de jaulas (TJ), convencionales vs...

  11. Aneurismas da aorta Aortic aneurysms

    Directory of Open Access Journals (Sweden)

    Januário M Souza

    1992-09-01

    Full Text Available Entre janeiro de 1979 e janeiro de 1992, foram realizadas 212 operações para correção de aneurismas e de dissecções da aorta. Neste trabalho serão analisados 104 procedimentos cirúrgicos (em 97 pacientes para correção de aneurismas. A idade dos pacientes variou de 14 a 79 anos (média 59,5 anos e o sexo predominante foi o masculino, com 75 pacientes. Os aneurismas localizavam-se na aorta ascendente em 46 pacientes, na croça em 8, na aorta descendente em 8, na aorta toráco-abdominal em 8, na aorta abdominal em 21, na aorta descendente e abdominal em 2, na aorta ascendente e tóraco-abdominal em 2, na aorta ascendente e descendente em 1, na aorta ascendente, croça e descendente em 1. Doenças cardiovasculares associadas estavam presentes em 39 pacientes, sendo valvopatia aórtica em 18 (excluídos os pacientes com ectasiaânulo-aórtíca, insuficiência coronária em 17, coarctação da aorta em 2, persistência do canal arterial em 1 e valvopatia mitral e aórtica em 1. A mortalidade imediata (hospitalar e/ou 30 dias foi de 14,4%, sendo de 27,7% (5/18 para pacientes com mais de 70 anos e de 11,3% (9/79 para pacientes com idade inferior a 70 anos. Os aneurismas localizados na aorta ascendente e croça foram operados como o auxílio de circulação extracorpórea. Parada circulatória e hipotermia profunda foram utilizadas em todos os pacientes com aneurisma da croça. O estudo tomográfico e angiográfico deve ser de toda a aorta, pela possibilidade de aneurismas de localizações múltiplas.Among 212 patients undergoing operation for aortic aneurysm and aortic dissection between January 1979 and January 1992, 97 were operated on for aneurysms. The aneurysms were localized in: ascending aorta in 46 patients, transverse aortic arch in 8, descending aorta in 8, thoracoabdominal aorta in 8, abdominal (infrarenal aorta in 21, descending and abdominal aorta in 2, ascending and thoracoabdominal aorta in 2, ascending and descending in 1

  12. Estudo histopatológico do efeito do tenoxicam com água bidestilada ou com cloreto de sódio a 0,9% no endotélio venoso de coelhos Estudio histopatológico del efecto del tenoxican con agua bidestilada o con cloreto de sodio a 0,9% en el endotélio venoso de conejos Histopathologic study on the effects of tenoxicam with bidistilled water or with 0.9% sodium chloride in rabbits venous endothelium

    Directory of Open Access Journals (Sweden)

    Taylor Brandão Schnaider

    2002-04-01

    humanas expuestas a la indometacina, fue observado aumento de la actividad pró-coagulante. Estudio en conejos comprobó la presencia de trombosis en las venas auriculares después de la administración de tenoxicam con su diluyente o de su diluyente aislado. No fueron encontrados estudios en la literatura consultada que hayan evaluado el endotélio venoso después de la administración de tenoxicam, en seres humanos. El objetivo de esta pesquisa fue evaluar se el tenoxicam con cloreto de sodio a 0,9% (NaCl a 0,9% provoca alteraciones en el endotélio venoso de conejos, como las observadas cuando asociado a su diluyente (agua bidestilada. MÉTODO: Noventa conejos (2.000 - 3.500 g fueron distribuidos aleatoriamente en dos grupos: Control, con administración de NaCl a 0,9%; Experimento, con tenoxicam (20 mg asociado a agua bidestilada o al NaCl a 0,9%. El volumen inyectado en los dos grupos fue constante de 2 ml. La anestesia fue inducida con maleato de acepromazina, clorhidrato de cetamina y clorhidrato de xilazina, siendo la punción de las venas auriculares caudales derecha e izquierda realizada con aguja tipo mariposa 27G. Los animales fueron mantenidos en el biotério por 6 h, 12 h e 24 h, nuevamente anestesiados y sometidos a eutanasia, siendo entonces realizada exéresis de las aurículas en su base y posterior evaluación microscópica de las venas. RESULTADOS: Se observó trombosis en el grupo Experimento, en una porcentaje de 19,4% después de administración del tenoxicam con agua bidestilada y 22,2% después administración del tenoxicam con NaCl a 0,9%. En el grupo Control, en que fue inyectado, solamente NaCl a 0,9%, ninguna de las venas presento trombosis. CONCLUSIONES: Los resultados encontrados permiten concluir que el tenoxicam, con agua bidestilada o con solución de cloreto de sodio a 0,9%, produjo trombosis en las venas en que fue inyectado.BACKGROUND AND OBJECTIVES: After exposure to indomethacin, human umbilical vein endothelial cells have shown

  13. Incidencia de la distomatosis hepática en los conejos de la ciudad de Lima y alrededores

    Directory of Open Access Journals (Sweden)

    Oswaldo Meneses

    1955-12-01

    Full Text Available En el lapso comprendido entre el 22 de enero y 22 de agosto de 1954, se llevó a cabo una encuesta en 538 conejos criados en Lima y alrededores tratando de determinar la incidencia de infestación por la Fasciola hepática. Se utilizó la técnica de sedimentación para el examen coprológico de las heces. Al mismo tiempo, paralelamente con la encuesta, se realizaron autopsias en conejos muertos por diversas causas con el fin de buscar F. hepática en el hígado. También se determinó la viabilidad de los huevos de F. hepática obtenidos de las heces de los conejos parasitados. De los estudios realizados se puede sacar las siguientes conclusiones: 1. Se ha verificado la presencia de Fasciola hepática en los conejos de Lima y alrededores. 2. La incidencia a F. hepática en los conejos estudiados varía entre 2.6 % y 19.7 % de acuerdo con la alimentación. 3. Son viables los huevos de F. hepática que el conejo arroja con las heces, lo que indica la posibilidad de que este animal podría actuar como reservorio de distomatosis hepática en la ciudad de Lima. 4. La técnica de sedimentación para el diagnóstico de la distomatosis en conejos ha demostrado ser superior a otras técnicas.

  14. Atherosclerotic Human Aorta

    Directory of Open Access Journals (Sweden)

    Igor A. Sobenin

    2011-01-01

    Full Text Available We have evaluated the binding of sialylated and desialylated lipoproteins to collagen isolated from the proteoglycan and musculoelastic layers of intima and media of uninvolved human aorta and atherosclerotic lesions. Comparing various collagen preparations from the uninvolved intima-media, the binding of sialylated apoB-containing lipoproteins was best to collagen from the intimal PG-rich layer. Binding of sialylated apoB-containing lipoproteins to collagen from this layer of fatty streak and fibroatheroma was 1.4- and 3.1-fold lower, respectively, in comparison with normal intima. Desialylated VLDL versus sialylated one exhibited a greater binding (1.4- to 3.0-fold to all the collagen preparations examined. Desialylated IDL and LDL showed a higher binding than sialylated ones when collagen from the intimal layers of fibroatheroma was used. Binding of desialylated HDL to collagen from the intimal PG-rich layer of normal tissue, initial lesion, and fatty streak was 1.2- to 2.0-fold higher compared with sialylated HDL.

  15. Evaluación del impacto de las técnicas de control del daño en el tratamiento de los pacientes con aneurisma roto de la aorta abdominal. Hospital Universitario San Vicente de Paúl, Medellín, Colombia, enero de 2000 a octubre de 2007

    Directory of Open Access Journals (Sweden)

    John Fernando García V.

    2008-11-01

    Full Text Available La mortalidad quirúrgica atribuible al aneurisma de la aorta abdominal (AAA roto oscila entre 40 y 70% según los diversos informes de la literatura; la principal causa de ello es la falla orgánica múltiple (FOM, la que a su vez corresponde, en un porcentaje importante de casos, al complejo de hipertensión abdominal/síndrome del compartimento abdominal (HTA/SCA. A principios de la década de los años 90 aparecieron algunos artículos informando que los pacientes tratados con laparostomía, con o sin empaquetamiento, cursaban sin HTA/SCA, y presentaban tasas de supervivencia mejores que las de aquellos a quienes se les cerraba primariamente el abdomen, luego de la corrección de un AAA roto. Decidimos tratar a la mayoría de los pacientes con laparostomía y empaquetamiento abdominal, con el fin de disminuir la mortalidad previa global del servicio, la cual había sido del 81,8% en 44 pacientes (corregida de 79,3%. Se exceptúan 6 pacientes a quienes se les hizo cierre primario de la pared abdominal al momento de corregir su AAA roto. Se obtuvo una tasa global de mortalidad a 30 días del 55,9% y corregida del 45,5%. Con lo anterior se puede concluir que a los pacientes con AAA roto, dada su gravedad, se les deben ofrecer técnicas similares a las utilizadas en el control del daño en el trauma, como la laparostomía y el empaquetamiento abdominal con el fin de que tengan la mejor oportunidad de sobrevivir.

  16. Comparación bromatológica, microbiológica y sensorial de dos formulaciones de salchichas elaboradas con carne de conejo (Oryctolagus cuniculus

    Directory of Open Access Journals (Sweden)

    José Igor Hleap Zapata

    2014-01-01

    Full Text Available En este estudio se evaluaron dos formulaciones diferentes de salchichas elaboradas con carne de conejo, utilizando como extendedores harina de chontaduro (Bactris gasipaes y almidón modificado de maíz. Ambas formulaciones consistieron en 60% de carne de conejo, 12% de grasa de cerdo y 4% del respectivo extensor, el porcentaje restante correspondió a hielo y condimentos. Los análisis bromatológicos mostraron los contenidos siguientes (base seca: (1 en carne = 60.90% de proteína, 33.65% de grasa, 4.46% de cenizas y 0.99% de carbohidratos; (2 en salchichas elaboradas con adición de harina de chontaduro = 15.96% de proteína, 13.55% de grasa, 4.10% de cenizas, 3.42% de carbohidratos y 60.63% de humedad; y (3 en salchichas elaboradas con adición de almidón modificado de maíz = 14.54% de proteína, 11.53% de grasa, 3.81% de cenizas, 3.99% de carbohidratos y 63.42% de humedad. Las pruebas microbiológicas consistieron en el análisis de los parámetros tradicionales de calidad y seguridad, además de mediciones sensoriales utilizando pruebas afectivas de preferencia, de grado de satisfacción y de aceptación que permitieron concluir que las salchichas elaboradas presentaron características de inocuidad para el ser humano y de gran aceptación gracias a sus buenas propiedades organolépticas, resultando productos tipo Premium según la NTC 1325.

  17. Hematoma da aorta ascendente Intramural hematoma of the ascending aorta

    Directory of Open Access Journals (Sweden)

    Noedir Antônio G. Stolf

    2006-12-01

    Full Text Available É relatado o caso de um paciente do sexo masculino com idade de 71 anos, dando entrada no pronto-atendimento com palidez cutaneomucosa, acompanhada de hipertensão arterial sistêmica e dor torácica. Na investigação diagnóstica não foi evidenciada alteração compatível com isquemia miocárdica aguda. A radiografia de tórax evidenciava alargamento importante do mediastino. Ao ecocardiograma, a aorta ascendente media 47 mm, no nível do tronco pulmonar. Um dia após o eco, o paciente foi submetido a exame de ressonância magnética (RNM, quando se evidenciou aorta ascendente de 62 mm, sem evidenciar fluxo em falsa luz ou "flap" intimal, mas mostrando hematoma intramural da aorta ascendente, estendendo-se da raiz da aorta até um terço proximal do arco aórtico. Procedeu-se a correção cirúrgica, sendo realizada substituição da aorta ascendente e parte do arco aórtico (hemiarco, com preservação da valva aórtica pela suspensão das comissuras. Paciente evolui bem sem intercorrência, recebendo alta no nono dia de pós-operatório. Enfatizamos nesse relato de caso a semelhança do quadro clínico do hematoma intramural da aorta com o quadro de dissecção da aorta, a importância de se estabelecer diagnóstico correto e o melhor tratamento.It is reported the case of a 71 year old male patient admitted to the emergency service pale and with systemic arterial hypertension and thoracic pain. In the diagnostic investigation, there was no evidence of compatible with acute myocardial ischemia. The thorax x-ray showed important enlargement of the mediastinum. In the echocardiogram the ascending aorta measured 47mm, at the level of the pulmonary artery. One day after the echo, submitted to exam of magnetic resonance (RNM, the ascending aorta had a diameter of 62mm, without false lumen flow or intimal "flap", but showing intramural hematoma envolving the ascending aorta and the proximal portion of the aorta. It was submitted to the surgical

  18. ¿Es necesaria la reconstrucción de la conjuntiva?: Trabajo experimental en conejos albinos para evaluar la neogénesis de la conjuntiva

    Directory of Open Access Journals (Sweden)

    E. A. Moretti

    Full Text Available En los defectos de espesor total del párpado inferior de gran magnitud, siempre ha sido regla de oro la reconstrucción de la lamela posterior (tarso y conjuntiva palpebral. Esto es debido a que el tono del músculo orbicularis oculi no alcanza a mantener el soporte necesario para resistir la acción de la gravedad y/o contractura cicatricial. Además la ausencia de conjuntiva provocaría lesiones sobre la córnea ocular. Es por ello que el empleo de injertos compuestos condromucosos ha sido insustituible. El presente trabajo de investigación fue realizado en 20 conejos albinos con el objeto de evaluar la posibilidad de emplear cartílago auricular para la reconstrucción del tarso sin colocación de mucosa a modo de conjuntiva sobre dicho cartílago. Los resultados obtenidos permiten confirmar por diferentes tinciones histológicas sobre biopsias comparadas con zonas testigo, el crecimiento de tejido conjuntival sobre el pericondrio sin provocar lesiones oculares (neogénesis de conjuntiva. Los hallazgos encontrados provocan importantes y sustanciales cambios en la cirugía reconstructiva del párpado inferior debido a que de esta manera, no sería necesaria la reconstrucción de la conjuntiva palpebral, siendo útil exclusivamente la colocación de cartílago.

  19. ANÁLISIS GENÉTICO DE LA GRASA INTRAMUSCULAR EN CONEJO-GENETIC ANALISYS OF INTRAMUSCULAR FAT IN RABBITS

    OpenAIRE

    Zomeño Segado, Cristina

    2013-01-01

    En esta tesis se aborda el estudio de la grasa intramuscular como característica determinante de la calidad de la carne para ser utilizado en programas genéticos. El conejo se plantea no sólo por su interés como especie ganadera sino como modelo en otras especies. Este estudio se divide en tres experimentos, cada uno de ellos representa cada uno de los tres objetivos específicos de esta tesis: 1. Estudiar la variabilidad genética entre líneas de conejo de factores ligados directamente a la...

  20. Incorporación de aceites poliinsaturados, alfatocoferol y minerales en pienso: Efectos sobre la composición y oxidación lipídica de plasma, hígado y carne de conejo

    OpenAIRE

    Tres Oliver, Alba

    2009-01-01

    En la presente Tesis Doctoral se estudió el efecto de la incorporación de aceites poliinsaturados, α-tocoferol y minerales en piensos sobre la composición en ácidos grasos, el contenido en α-tocoferol, la oxidación (índice del ATB) y la susceptibilidad a la oxidación (método inducido del naranja de xylenol) de plasma, hígado y carne de conejo. También se estudiarion los efectos de la cocción y la conservación a refrigeración de la carne cocida sobre estos parámetros. En un primer es...

  1. Coarctation of the Aorta (For Teens)

    Science.gov (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Coarctation of the Aorta KidsHealth > For Teens > Coarctation of ... of Yourself en español Estrechamiento aórtico What Is Coarctation of the Aorta? The aorta (pronounced: ay-OR- ...

  2. Subtle traps in Cretaceous, Archuleta, Conejos, Mineral, and Rio Grande counties, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Brown, W.T. Jr. (Coastal Oil and Gas Corp., Denver, CO (USA))

    1989-09-01

    Regional interpretation of the stratigraphy, faulting, fracturing, and hydrodynamics in Archuleta, Conejos, Mineral, and Rio Grande Counties in southern Colorado indicates that significant reserves of hydrocarbons could exist in subtle trapping situations within the Cretaceous sequences. The presence of Price-Gramps field (7 million bbl of oil ultimate recoverable), which produces primarily from the Dakota Formation, is presently anomalous in this area but is indicative of existing hydrocarbon potential. Hydrocarbon shows from drilled wells and outcrops suggest that significant quantities of hydrocarbons are present in this area, sourced both from the San Juan basin to the south and west, and from more local areas for fractured reservoirs.

  3. Efectos del extracto de croton schiedeanus sobre la producción de oxido nítrico en la preparación de anillos aislados de aorta / Effects of croton schiedeanus extract on nitric oxide production in the preparation of isolated aortic rings

    OpenAIRE

    Chaves Torres, Ninfa Marlen

    2010-01-01

    En este trabajo se determinó la importancia de la ruta metabólica del óxido nítrico y la guanilato ciclasa en el efecto vasodilatador inducido por el extracto de Croton Schiedeanus Schlecht utilizando la preparación de anillos aislados de aorta de ratas Wistar. El extracto de C. Shiedeanus relaja anillos precontraídos con fenilefrina, agonista del receptor adrenérgico alfa, en función de la dosis, con una CE50 de 1,3x10-5 g/mL (9,1x10-6 – 2x10-5). Este efecto es superior al ejercido sobre ani...

  4. Suplementación con bloques de melaza-urea en dietas a base de forrajes en la alimentación de conejos

    Directory of Open Access Journals (Sweden)

    Quintero de Vallejo Victoria E.

    1995-06-01

    registrándose el mayor consumo con concentrado comercial (5440 g No hubo diferencias en el consumo por efecto de los forrajes, ni por el nivel de úrea pero si por el uso de salvado de arroz (3132 Vs 3930 g. Hubo diferencia significativas (P < 001 para la ganancia de peso diaria entre tratamientos siendo mayor en el concentrado (35.9, por efecto del forraje, siendo mejor con nacedero (17.85; por efecto del uso de úrea siendo mejor sin úrea y por efecto del uso de salvado (20.8 gd. Para la conversión hubo diferencias significativas (P<005 entre tratamientos, siendo el mejor para el concentrado (3.1, por efecto del forraje, mejor para el naced ero (4.5, por efecto del uso de mejor sin úrea y por efecto del uso de salvado, mejor con salvado de arroz (4.02. El mayor beneficio neto se registró en el tratamiento con Nacedero y salvado de arroz ($2119. En el experimento dos se emplearon 20 conejos en un diseño completamente al azar. Hubo diferencias significativas (P<001 entre tratamientos para el consumo de materia seca, siendo mayor para el concentrado (5877 g, también por efecto del forraje, siendo mayo r con nacedero (4277 g. Para la ganancia de peso diaria hubo diferencia significativas (P<001 entre tratamientos siendo mayor para el concentrado (28, por efecto de los forrajes, siendo mejor para el nacedero (19.5. El ingreso neto fue mayor en el tratamiento con matarratón y bloque ($1298.7.

  5. Effects of irrigation water supply variations on limited resource farming in Conejos County, Colorado

    Science.gov (United States)

    Eckert, Jerry B.; Wang, Erda

    1993-02-01

    Farms in NE Conejos County, Colorado, are characterized by limited resources, uncertain surface flow irrigation systems, and mixed crop-livestock enterprise combinations which are dependent on public grazing resources. To model decision making on these farms, a linear program is developed stressing enterprise choices under conditions of multiple resource constraints. Differential access to grazing resources and irrigation water is emphasized in this research. Regarding the water resource, the model reflects farms situated alternatively on high-, medium-, and low-priority irrigation ditches within the Alamosa-La Jara river system, each with and without supplemental pumping. Differences are found in optimum enterprise mixes, net returns, choice of cropping technology, level of marketings, and other characteristics in response to variations in the availability of irrigation water. Implications are presented for alternative improvement strategies.

  6. Geologic Map of the San Luis Hills Area, Conejos and Costilla Counties, Colorado

    Science.gov (United States)

    Thompson, Ren A.; Machette, Michael N.

    1989-01-01

    This report is a digital image of the U.S. Geological Survey Miscellaneous Investigations Series Map I-1906, 'Geologic map of the San Luis Hills area, Conejos and Costilla Counties, Colorado,' which was published in 1989 by Thompson and Machette, scale 1:50,000 but has been unavailable in a digital version. The map area represents the southwestern portion of the Alamosa 30' x 60' quadrangle, which is currently being remapped by the U.S. Geological Survey. The northern and eastern margins of the San Luis Hills area have been remapped at greater detail and thus small portions of the map area have been updated. The northern margin is shown on U.S. Geological Survey Open-File Report 2005-1392, the northeastern portion is shown on U.S. Geological Survey Open-File Report 2008-1124, and the eastern margin is shown on U.S. Geological Survey Open-File Report 2007-1074. The most significant changes to the 1989 map area are recognition of Lake Alamosa and its deposits (Alamosa Formation), remapping of bedrock in the northeastern San Luis Hills, and redating of volcanic units in the San Luis Hills. Although unpublished, new 40Ar/39Ar ages for volcanic units in the Conejos and Hinsdale Formations add precision to the previous K/Ar-dated rocks, but do not change the basic chronology of the units. The digital version of this map was prepared by Theodore R. Brandt by scanning the original map at 300 pixels per inch, prior to creating the press-quality (96 Mb) and standard (5 Mb) .pdf files.

  7. Acute spontaneous isolated dissection of abdominal aorta

    Directory of Open Access Journals (Sweden)

    Ali Akbar beigi

    2009-09-01

    Full Text Available

    • Aortic dissection occurs when the layers of the aorta separate as a result of extra luminal cavity of blood through an intimal tear. Dissection limited to the abdominal aorta is rare. Unfortunately, the appropriate management of dissecting aneurysm of abdominal aorta is not documented yet. A 43 years old man was admitted to Al-zahra hospital in Isfahan with sudden onset of periumbilical abdominal pain. CT scan confirmed infrarenal dissection of abdominal aorta. Performing laparotomy, aorta was repaired using bifurcate collagen-coated Dacron graft. Surgical intervention with synthetic graft is recommended in patients with dissecting aortic aneurysm of infrarenal segments where the extent of dissection is limited and accessible.
    • Keywords: Aneurysm, Aortic dissection, Aortic aneurysm abdominal surgery.

  8. COMPORTAMIENTO MECANICO DE LA AORTA ASCENDENTE: CARACTERZACION EXPERIMENTAL Y SIMULACION NUMERICA.

    OpenAIRE

    GARCIA HERRERA, CLAUDIO

    2008-01-01

    En este trabajo se realiza una caracterización experimental y numérica del comportamiento mecánico de la pared de la aorta humana. Se destaca la importancia (le este tema debido al creciente interés cii coiiocer las propiedades y la respuesta mecánica de 193p.

  9. Human Aorta Is a Passive Pump

    Science.gov (United States)

    Pahlevan, Niema; Gharib, Morteza

    2012-11-01

    Impedance pump is a simple valveless pumping mechanism that operates based on the principles of wave propagation and reflection. It has been shown in a zebrafish that a similar mechanism is responsible for the pumping action in the embryonic heart during early stages before valve formation. Recent studies suggest that the cardiovascular system is designed to take advantage of wave propagation and reflection phenomena in the arterial network. Our aim in this study was to examine if the human aorta is a passive pump working like an impedance pump. A hydraulic model with different compliant models of artificial aorta was used for series of in-vitro experiments. The hydraulic model includes a piston pump that generates the waves. Our result indicates that wave propagation and reflection can create pumping mechanism in a compliant aorta. Similar to an impedance pump, the net flow and the flow direction depends on the frequency of the waves, compliance of the aorta, and the piston stroke.

  10. Multiple tuberculous aneurysms of the aorta.

    Science.gov (United States)

    Pierret, Charles; Tourtier, Jean-Pierre; Grand, Bertrand; Boddaert, Guillaume; Laurian, Claude; de Kerangal, Xavier

    2011-06-01

    Tuberculous aneurysms of the aorta are quite rare, but are exceptional when found in multiple locations. We report the case of multiple tuberculous aortic aneurysms of the thoracic and abdominal aorta in a 19-year-old female discovered when she consulted for thrombocytopenic purpura. The treatment for both locations included prolonged antituberculous therapy and surgical resection with cryopreserved aortic allograft patch for the reconstruction.

  11. Influencia de la madurez sexual y la castración sobre la actividad eléctrica cardíaca en conejos machos y hembras

    Directory of Open Access Journals (Sweden)

    Gabriela Y. Eizikovits

    2010-08-01

    Full Text Available Es bien conocida la existencia de diferencias en la actividad eléctrica cardíaca asociadas al sexo. Si bien estas diferencias habitualmente se relacionan al efecto de la madurez y de las hormonas sexuales gonadales, todavía existen controversias al respecto. El objetivo de este trabajo fue evaluar el efecto que la madurez sexual y la castración producen sobre los distintos parámetros del electrocardiograma de superficie y de la duración de los potenciales de acción (DPA. Se utilizaron conejos jóvenes (menores de un mes de edad y adultos (mayores de seis meses de edad. Las diferencias obtenidas en las hembras se observan en la repolarización tardía, mientras que en los machos ocurren en la repolarización temprana. Existiría una relación entre las diferencias observadas en la duración desde el pico máximo hasta el fin de la onda T (Tpf y las observadas en la DPA al 90% de la repolarización (DPA90 en las hembras, mientras que en los machos la relación existe entre la duración desde el punto J hasta el pico máximo de la onda T (JTp y la DPA al 30 y 50% de la repolarización (DPA30 y DPA50. Si bien existen diferencias que podrían ser debidas a factores hormonales otras serían debidas a factores no hormonales.

  12. Inhibición de colonización intestinal por Vibrio cholerae con Lactobacillus acidophilus1 en conejos lactantes

    Directory of Open Access Journals (Sweden)

    Alvaro Pazos M.

    2013-10-01

    Full Text Available Objetivo. Evaluar la capacidad in vitro e in vivo de Lactobacillus acidophilus1, aislado en este estudio, para prevenir enfermedad diarreica causada por Vibrio cholerae 01 OGAWA, en conejos lactantes. Materiales y métodos. Se aisló Lactobacillus acidophilus1 a partir de heces de niños sanos, se seleccionó por su capacidad amilolítica a partir de un grupo de bacterias ácido lácticas (BAL. El mejor sustrato amiláceo para el crecimiento de la BAL fue estandarizado previamente. Con L. acidophilus1 se realizó un ensayo in vitro e in vivo de inhibición antagónica sobre el enteropatógeno y se evaluó la prevención de la colonización por V. cholerae 01 OGAWA en conejos lactantes. Resultados. De acuerdo con el análisis de varianza L. acidophilus1 presentó la mejor capacidad amilolítica respecto a las otras BAL aisladas, p<0.5. Se encontró que un inóculo con una densidad celular de 35x106 bacterias/ml en el fermento láctico es capaz de ejercer el mayor efecto antagónico in vitro sobre V. cholerae. Se demostró el efecto probiótico in vivo, ya que los conejos enfrentados con el patógeno y sin recibir probiótico tuvieron una probabilidad de sobrevida menor de 0.25 respecto al grupo de animales retados con el patógeno y simultáneamente alimentados con el probiótico cuya probabilidad de sobrevida fue de 0.95. Conclusiones. L. acidophilus1 se considera un microorganismo probiótico, capaz de sobrevivir a su paso por el tracto gastrointestinal en un modelo animal y prevenir la colonización intestinal por V. cholerae 01 OGAWA en conejos lactantes.

  13. Evaluación de tres niveles de nacedero Trichantera gigantea (10%, 20%, 30% en ceba de conejos

    Directory of Open Access Journals (Sweden)

    Arango Juan Fernando

    1990-12-01

    Full Text Available En el corregimiento de El Lauro, Palmira, Colombia, se realizó un experimento para evaluar tres niveles de Trichantera gigantea (10%, 20%, 30% en dietas balanceadas y peletizadas para conejos con un tratamiento testigo de concentrado comercial. Se emplearon 64 conejos Nueva Zelanda blancos con 35 días de edad, distribuidos en un diseño completamente al azar, con 4 tratamientos, 4 repeticiones y 4 conejos por unidad experimental. La unidad experimental estaba constituida por 4 conejos alojados en jaulas de 1.0 m largo, 0.5 m alto, 0.5 m ancho. Se evaluaron las variables: consumo de alimento, ganancia de peso, conversión alimenticia y tiempo en semanas para la ceba. El mayor consumo de alimento se presentó en el tratamiento con 30 % de Trichantera (110 g/d, la mejor ganancia diaria (32.29 g/d y mejor conversión (3.49 con el tratamiento testigo. El tratamiento con 30 % de Trichantera registró una ganancia diaria similar al testigo (32.12 y conversión aceptable (4.2 y fue el tratamiento de mayor beneficio neto. Los menores tiempos de ceba se presentaron en el testigo (41.3 días y tratamiento con 30 % de Trichantera (46.9 días.At "El Lauro" village, Palmira, Colombia was done an experiment for evaluating three levels of Trichantera gigantea (10, 20, 30 % in pelleted and balanced diets for rabbits, using commercial feed as a control treatment. Sixty-four New Zeland rabbits 35 days old were distributed in a complete randomized design, using four treatments, four replications and four rabbits for experimental unit. They were located in wire cages, 1.0 m long, 0.5 high and 0.5 m wide. The variables evaluated were: feed compsumption weight gain, feed efficiency and time to reach the final weight. The great feed comsumption was for the 30 % Trichantera (110 g/d, the best daily gain (32.3 g/d and feed efficiency (3.49 for the control treatment. The 30 % treatment showed a similar result for daily gain (32.12 and a fair feed efficiency (4.2; it had

  14. Aproximación a las urgencias y cuidados intensivos en conejos, psitácidas y reptiles

    OpenAIRE

    Ardiaca, M.; Brotóns, N. J.; Montesinos, A.

    2010-01-01

    Las clínicas de perros y gatos atienden cada vez con mayor frecuencia a un número importante de urgencias de animales exóticos. Aunque los principios de atención clínica de urgencia son similares, la fisiología y el comportamiento de estas especies determinan ciertas particularidades que deben tenerse en cuenta. Se describen los requerimientos mínimos para la atención de urgencias de conejos, aves psitácidas y reptiles en clínicas cuyos pacientes mayoritarios son perros y gatos. Además, se de...

  15. Incorporación de aloinjertos óseos intercalares corticales: Estudio experimental en conejos Incorporation of cortical intercalary bone allografts: Experimental study on rabbits

    Directory of Open Access Journals (Sweden)

    S. Amillo

    2003-12-01

    Full Text Available Se realiza un estudio experimental en 40 conejos para valorar la incorporación de grandes aloinjertos óseos intercalares y la influencia de la congelación en el injerto óseo. En 36 conejos adultos se procedió a resecar 3 centímetros diafisarios de tibia y el defecto se reconstruyó con diferente tipo de injerto óseo: autoinjerto fresco y autoinjerto congelado, aloinjerto fresco y aloinjerto congelado; la osteosíntesis se realizó con dos agujas de Kirschner intramedulares. Se hicieron estudios radiológicos mensuales hasta el sacrificio, a los 2, 4 y 8 meses. Se hizo un estudio densitométrico, histológico y de diafanización con técnica de Spalteholz de las tibias. En 24 animales se administraron 25 mg/kg de oxytetraciclina al 3º y 6º días antes del sacrificio para estudiar la velocidad de aposición ósea en el injerto. Observamos una consolidación radiológica buena y excelente en el 80% de los injertos (99% en los autoinjertos y 66% en los aloinjertos. La densidad ósea mostraba un descenso hasta el 4º mes debido a la reabsorción ósea excepto en el grupo de los aloinjertos frescos. La revascularización de los aloinjertos fue más lenta y pobre que en los autoinjertos, pero con el mismo patrón vascular. La incorporación y neoformación ósea fueron mayores en los autoinjertos sin diferencias significativas con los aloinjertos congelados. La velocidad de aposición ósea no se modificó con los diferentes tipos de injertos óseos utilizados. La congelación facilita y acelera la incorporación y cantidad de neoformación ósea de los aloinjertos.An experimental study was carried out on 40 rabbits in order to evaluate the incorporation of large intercalary bone allografts and the influence of freezing on the bone graft. In 36 rabbits resection of 3 centimetres of diaphysis of the tibia was carried out and the defect was rebuilt with different types of bone graft: fresh autograft and frozen autograft, fresh allograft and

  16. Digital subtraction angiography of the thoracic aorta

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, L.B.; Buonocore, E.; Modic, M.T.; Meaney, T.F.

    1984-02-01

    Forty-three patients with acquired and congenital abnormalities of the thoracic aorta were studied using digital subtraction angiography (DSA) after an intravenous bolus injection of 40 ml of contrast material. Abnormalities studied included coarctation, pseudocoarctation, Marfan syndrome, cervical aorta, double aortic arch, aneurysm, dissection, and tumor. Twenty-four patients also had conventional angiography. DSA was accurate in 95% of cases; in the other 5%, involving patients with acute type I dissection, the coronary arteries could not be seen. The authors concluded that in 92% of their patients, DSA could have replaced the standard aortogram.

  17. Pseudoprominent aorta: Radiographic findings and CT correlation

    Energy Technology Data Exchange (ETDEWEB)

    Brown, K.T.; Shepard, J.A.O.; Stewart, W.J.

    1985-05-01

    The presence of a persistent left-sided superior vena cava (LSVC) in the absence of a right-sided superior vena cava (RSVC) may be suspected on a posteroanterior (PA) chest radiograph because of a prominent-appearing ascending aorta, which results from the absence of the RSVC. In the absence of an RSVC, the right upper lobe abuts and outlines the course of the ascending aorta, allowing better demonstration of its profile. This report describes a patient with this finding on a PA chest radiograph. Computed tomographic correlation is presented.

  18. Mycotic aneurysm rupture of the descending aorta

    Energy Technology Data Exchange (ETDEWEB)

    Gufler, H.; Buitrago-Tellez, C.H.; Nesbitt, E.; Hauenstein, K.H. [Department of Radiology, Albert-Ludwigs-Universitaet, Freiburg (Germany)

    1998-03-01

    A 69-year-old diabetic male with salmonella bacteremia developed hypovolemic shock and swelling of the neck. A CT examination revealed massive mediastinal hemorrhage extending into the neck soft tissues caused by false aneurysm rupture of the descending thoracic aorta. Aortography showed continuous extravasation from a large leak at the medial side of the descending thoracic aorta. Although surgical intervention was immediately performed, the patient died 3 weeks later from multiple-organ failure. In this report, CT and angiographic findings of mycotic aneurysm rupture are presented and a review is given. (orig.) With 2 figs., 11 refs.

  19. Platelet affinity for burro aorta collagen

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M.D.

    1977-10-01

    Despite ingenious concepts, there are no unequivocal clues as to what, when, and how some undefined biochemical factor(s) or constituent(s) that localizes in the arterial wall can precipitate a thromboatheromatous lesion or arterial disease. The present study focused on the extraction, partial purification, and characterization of a collagen-active platelet stimulator from the aortas of aged burros. The aggregator moiety in the aorta extracts invariably had a higher affinity for platelets in citrated platelet-rich plasma of human beings than for platelets of homologous burros. The platelet-aggregating factor(s) in the aorta extract was retained by incubation with ..cap alpha..-chymotrypsin. Platelet-aggregating activity was rapidly abolished after incubation with collagenase, as determined by platelet-aggregometry tests. Evidence based on light microscope and polysaccharide histochemical reactions indicates a probability that the intracellular amorphous matrix (PAS-positive) and filamentous components (PTAH-positive) expelled from smooth muscle cells disrupted during homogenization of the aorta may be a principal source of a precursor collagen species which is a potent inducer of platelet aggregation.

  20. Thoracic aorta stent grafting through transapical access.

    NARCIS (Netherlands)

    Saouti, N.; Vos, J.A.; Heuvel, D. van de; Morshuis, W.J.; Heijmen, R.H.

    2015-01-01

    BACKGROUND: To describe the transapical approach for thoracic endovascular aortic repair (TEVAR). METHODS: Three patients, 2 elective and 1 emergent, with thoracic aorta aneurysm are described with vascular or direct aortic inaccessible access, who underwent TEVAR through transapical access. The tec

  1. Abdominal aorta transplantation after programmed cryopreservation

    Institute of Scientific and Technical Information of China (English)

    Song Gu; Chang-Jian Liu; Tong Qiao; Xue-Mei Sun; Jun-Hao Chen

    2004-01-01

    AIM: To study the morphologic and cellular immunologic changes after homologous transplantation of the abdominal aorta in rats after programmed cryopreservation (-196°C).METHODS: Abdominal aorta was harvested from anesthetized Spraque Dawley (SD) rats for cryopreservation (group B) or immediate implantation (group A). The survival rates and apoptotic rates of aortic endothelial cells (ECs)were examined. The patency rates, histology and cellular immunologic changes of the abdominal aorta were examined on days 1, 3, 7, 14, 30, 60 after transplantation respectively.RESULTS: The survival rate of ECs after programmed cryopreservation was 90.1±1.79%, about 3.4% lower than that of uncryopreservation (93.5±1.96%). The apoptotic rates of ECs was increased after cryopreservation (7.15%vs 4.86%, P<0.05). The patency rate of group B was significantly higher than that of group A (91.6±12.9% vs 62.5±26.2%, P<0.01). CD4/CD8 ratio, TCR αβ and CD11b/CD18 ratio of group B were significantly lower than those of group A (P<0.05). Revivification of the cryopreserved abdominal aorta showed normal adventitia and intact smooth muscle cells.CONCLUSION: Cryopreservation can reduce homologous abdominal aortic antigenecity. Even if without administration of immunosuppressive agents, it is still feasible to implement homologous artery grafting in rats.

  2. Surgery of gigantic infrarenal aneurysm of abdominal aorta

    Directory of Open Access Journals (Sweden)

    N. Rustempašić

    2005-08-01

    Full Text Available The case shows gigantic aneurysm of abdominal aorta, localized infrarenally, as well as aneurysms of bilateral iliac arteries, which were solved successfully by resection of aneurism of abdominal aorta, closure of iliac arteries near aortic bifurcation, and interposition of aorta-bifemural vascular graft. There were no postoperative complications,and final outcome was fully satisfactory.

  3. [Ascending aorta-supraceliac++ aorta bypass. Correction of a case of atypical coarctation in the adult].

    Science.gov (United States)

    Vaquero, F; Zorita, A; Samos, R F; Vázquez, J G; Ortega, J M; Morán, C F

    1993-01-01

    A case of atypic coarctation at the aortic arch in an adult patient is described. Coarctation was surgically treated by a retrosternal bypass from the ascendant aorta to the supra-celiac aorta. After a short prelude the clinical case is summarized. Furthermore, the etiopathogenic features of the disease, the different diagnostic methods and the multiple surgical procedures are discussed. Finally, we briefly review the literature.

  4. Tratamiento endovascular de la aorta torácica descendente. Tratamiento endovascular de la aorta torácica descendente.

    Directory of Open Access Journals (Sweden)

    Hernán G. Bertoni

    2007-01-01

    Full Text Available ObjetivoEl propósito de esta publicación es comunicar nuestros resultados inmediatos y a mediano plazo del tratamiento endovascular de la aorta torácica descendente mediante implante de endoprótesis.Material y métodosEntre agosto de 1999 y agosto de 2006, 74 pacientes consecutivos, 53 hombres y 21 mujeres, fueron tratados por vía endovascular con implante de una prótesis autoexpandible. La edad media fue de 60 ± 14,8 años. Las indicaciones para tratamiento fueron disección aguda (n = 8; 11%, disección crónica (n = 31; 42%, hematoma intramural (n = 5; 7%, aneurisma verdadero (n = 17; 23%, úlcerapenetrante (n = 4; 5% y seudoaneurisma traumático (n = 9; 12%.ResultadosEl implante del dispositivo fue exitoso en 73 (98,6% pacientes; no se requirió conversión quirúrgica en ninguno de ellos. Ningún paciente presentó paraplejía o déficit neurológico. La mortalidad a los 30 días fue del 8,1% (n = 6. La mediana de seguimiento fue de 33,5 meses (rango 1-79 y la sobrevida global fue del 84% (IC 69-92% y del 91% (IC 77-97%, según se incluyese o no la mortalidad temprana. El 93% (IC 84-97% de los pacientes estaban libres de complicaciones relacionadas con el procedimiento. La mayoría de las complicaciones ocurrieron durante el primer año de seguimiento.ConclusionesEl tratamiento endovascular de la aorta torácica descendente con implante de endoprótesis autoexpandible es factible y seguro. La baja incidencia de eventos en relación con las series quirúrgicas publicadas hace que este procedimiento sea de elección en pacientes seleccionados.

  5. Influencia de la geometría de aneurismas de aorta abdominal en la dinámica del flujo sanguíneo y en su riesgo de ruptura // Influence of abdominal aortic aneurysms geometry in the blood flow dynamics and in its rupture risk.

    Directory of Open Access Journals (Sweden)

    G. Vilalta

    2009-05-01

    Full Text Available La ruptura de aneurisma de aorta abdominal (AAA representa un evento clínico muy importante,con una tasa de mortalidad relativamente elevada. En un esfuerzo por aumentar la comprensiónsobre este complejo fenómeno, en el presente trabajo se estudia la influencia de la geometría delos aneurismas de aorta abdominal en el riesgo de ruptura. Para esto se ha utilizado un modelogeométrico realista, obtenido por la transformación de imágenes 2D de tomografía computarizada(CT, sometido a un flujo pulsátil fisiológicamente realista, con el objetivo de evaluar e identificarlas regiones donde ocurren las principales perturbaciones en los patrones de flujo, cómo éstamodifica los campos de velocidades y de tensiones hemodinámicas en el interior del sacoaneurismático, así como la influencia de los diferentes factores biomécanicos relacionados con lageometría que caracterizan el aneurisma. Se presenta una explicación de las modificaciones de lasestructuras vorticales y de la distribución de tensiones durante el ciclo cardíaco. Igualmente sedetermina un indicador numérico (Parámetro de Severidad que integra los 3 factoresbiomecánicos geométricos y que permite evaluar el riesgo de ruptura del aneurisma para un estadode desarrollo determinado. Los resultados confirman que la asimetría de los aneurismas de aortaabdominal es uno de los principales factores que influyen en su ruptura.Palabras claves: AAA, asimetría, riesgo de ruptura, factores biomecánicos.__________________________________________________________________________AbstractThe rupture of abdominal aortic aneurysm (AAA represents an important clinical event, with arelatively high mortality rate. In an effort to increase understanding about this complexphenomenon, this paper studies the influence of abdominal aortic aneurysms geometry on the riskof rupture. Patient specific AAA model, created by 2D reconstruction of computed tomographyimage, was used to identify regions of

  6. [Ascending aorta replacement late after aortic valve replacement].

    Science.gov (United States)

    Hayashi, Yasunari; Ito, Toshiaki; Maekawa, Atsuo; Sawaki, Sadanari; Fujii, Genyo; Hoshino, Satoshi; Tokoro, Masayoshi; Yanagisawa, Junji

    2013-07-01

    Replacement of the asceding aorta is indicated in patients undergoing aortic valve replacement( AVR), if the diameter of the ascending aorta is greater than 5.0 cm. If the diameter of the asceding aorta is from 4.0 to 5.0 cm, it was arguable whether replacement of the ascending aorta should be performed. Nine patients who underwent reoperative ascending aorta replacement after AVR were reviewed retrospectively. Reoperation on the asending aorta replacement was performed 11.8±7.2 years (range 1y5m~23y3m) after AVR. Mean patient age was 69.9±6.3 (range 60~81). In 2 cases, reoperations were performed early year after AVR. Although ascending aorta was dilated at the 1st operation, replacement wasn't performed for the age and minimally invasive cardiac surgery (MICS). In 3 cases, reoperations were performed more than 10 years later. On these cases, ascending aorta aneurysm and dissection occurred with no pain and were pointed out by computed tomography(CT) or ultrasonic cardiogram(UCG). We think that patients with dilatation of the ascending aorta should undergo AVR and aorta replacement at the 1st operation regardness of age. It is important that patients who underwent AVR should undergo a regular checkup on the ascending aorta.

  7. Atrophic coarctation of the abdominal aorta.

    Science.gov (United States)

    Wiest, J W; Traverso, L W; Dainko, E A; Barker, W F

    1980-01-01

    Two cases illustrate the clinical manifestations and angiographic findings associated with segmental stenosis of the abdominal aorta. Such lesions represent the chronic occlusive stage of Takayasu's disease, a nonspecific inflammatory arteritis of uncertain etiology. While the disease is considered autoimmune, an infectious process may be involved. Complications typically associated with stenotic lesions of the abdominal aorta are secondary renal hypertension and ischemic symptoms secondary to vascular insufficiency. Surgical correction, the treatment of choice, has achieved excellent results for these well-localized lesions. Secondary renal hypertension was relieved by a spenorenal shunt and the disease has since been controlled with conservative management in the first patient. An aortofemoral bypass graft successfully alleviated the vascular insufficiency in the second patient, although the patient unfortunately expired from a refractory postoperative cardiac complication. Images Fig. 1. Fig. 2. Fig. 3. Fig. 4. PMID:6102453

  8. Anestesia para intervenção cirúrgica endovascular na aorta abdominal Anestesia para intervención quirúrgica endovascular en la aorta abdominal Anesthesia for endovascular surgery of the abdominal aorta

    Directory of Open Access Journals (Sweden)

    Michelle Nacur Lorentz

    2008-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O procedimento endovascular para correção de aneurisma de aorta é menos invasivo que o convencional, além de apresentar outras vantagens, como ausência de incisão abdominal, ausência de pinçamento da aorta e menor tempo de recuperação pós-operatória. Por se tratar de procedimento cirúrgico relativamente novo e apresentar uma série de alterações que devem ser conhecidas pelo anestesiologista foi realizado este trabalho com o objetivo de revisar os aspectos mais relevantes do procedimento endovascular e possibilitar manuseio anestésico mais adequado no perioperatório. CONTEÚDO: Apresentação sucinta da técnica cirúrgica para reparo de aneurismas via endovascular, as possíveis vantagens e desvantagens do procedimento, bem como as complicações potenciais. Além disso, foram abordados os cuidados perioperatórios que o procedimento exige e as técnicas anestésicas que podem ser utilizadas. CONCLUSÕES: O conhecimento das alterações provenientes do procedimento endovascular possibilita conduta anestésica mais adequada e melhora dos resultados perioperatórios nesses pacientes.JUSTIFICATIVA Y OBJETIVOS: El procedimiento endovascular para la corrección del aneurisma de aorta es menos invasivo que el convencional, además de presentar otras ventajas como la ausencia de incisión abdominal, ausencia de pinzamiento de la aorta y un menor tiempo de recuperación postoperatoria. Por tratarse de un procedimiento quirúrgico relativamente nuevo y por presentar una serie de alteraciones que deben ser conocidas por el anestesiólogo, se realizó este trabajo con el objetivo de revisar los aspectos más relevantes del procedimiento endovascular y posibilitar el manejo anestésico más adecuado en el perioperatorio. CONTENIDO: Sencilla presentación de la técnica quirúrgica para la cura de aneurismas vía endovascular, las posibles ventajas y desventajas del procedimiento, como también las complicaciones

  9. [Takayasu's disease disclosed by isolated involvement of the ascending aorta].

    Science.gov (United States)

    Marcaggi, X; Courant, N; Soubrier, M; Kemeny, J L; Camilleri, L; Lusson, J R; Cassagnes, J

    1992-03-01

    The authors report the histological discovery of a case of Takayasu syndrome affecting the ascending aorta. This involvement appearing to concern only the aorta, with no symptomatic complaints nor any laboratory abnormalities indicative of an inflammatory syndrome, corticosteroids were not prescribed. Management consisted of biennial monitoring by transthoracic and transesophageal ultrasonography of the aorta and the supra-aortic main vessels together with monitoring of laboratory parameters.

  10. Aneurismas complejos de la aorta abdominal: cirugía abierta frente a exclusión endovascular avanzada. Estudio comparativo.

    OpenAIRE

    2015-01-01

    Justificación del estudio e hipótesis de trabajo: la enfermedad aneurismática de la aorta se estima que afecta al 2%-7% de los varones mayores de 60 años. Dichas estimaciones, extrapoladas a la población de España, se corresponderían con 140.000-350.000 personas portadoras de una aneurisma de aorta abdominal. En siete de cada cien personas acaece la rotura del aneurisma, siendo actualmente la décima causa de muerte en varones mayores de 55 años. En aquellos pacientes de alto riesgo para la ci...

  11. AORTA: Adding Organizational Reasoning to Agents

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Dignum, Virginia

    2014-01-01

    the expected behavior of the agents. Agents need to be able to reason about the regulations, so that they can act within the expected boundaries and work towards the objectives of the organization. This extended abstract introduces AORTA, a component that can be integrated into agents’ reasoning mechanism......, allowing them to reason about (and act upon) regulations specified by an organizational model using simple reasoning rules. The added value is that the organizational model is independent of that of the agents, and that the approach is not tied to a specific organizational model....

  12. Dynamic Morphology of the Aorta. Pre- and postoperative imaging

    NARCIS (Netherlands)

    van Prehn, J.

    2009-01-01

    With endovascular treatment of the aorta a folded covered stentgraft is introduced in the aorta via the femoral arteries. Adequate pre-operative planning is necessary to allow for proper stentgraft sizing. Stentgrafts should be adequately oversized to ensure good apposition to the aortic wall and pr

  13. Stent migration during transcatheter management of coarctation of aorta.

    Science.gov (United States)

    Kannan, Bhava R J; Srinivasan, Muthusamy

    2012-02-15

    A 13-year-old girl underwent endovascular stent placement for coarctation of aorta. The fully expanded stent migrated to ascending aorta which could be stabilized, recrimped, and repositioned with a 20-mm goose neck snare. Postdilatation was performed from the left brachial route resulting in a good outcome.

  14. Coil embolization of an anastomotic leak after ascending aorta replacement

    DEFF Research Database (Denmark)

    Nørgaard, Anders; Andersen, Lars Ib; Haahr, P.E.

    2008-01-01

    Surgical treatment of diseases of the thoracic aorta (aneurysms, dissections, and ruptures) may be associated with serious postoperative complications. Endovascular repair of thoracic aorta pathology is less invasive and offers a therapeutic alternative in high-surgical-risk patients, particularly...... accepted--embolization with endovascular coils--successfully resulting in occlusion of the leakage....

  15. Alternativas a la producción y mercadeo para la carne de conejo en Tlaxcala, México

    Directory of Open Access Journals (Sweden)

    Rodrigo Olivares Pineda

    2009-01-01

    Full Text Available La cunicultura es una actividad importante en Tlaxcala, en comparación con otras entidades productoras, por lo que se elaboró un diagnóstico técnico-económico sobre ella. Además, se analizaron algunos de los canales de comercialización, para proponer estrategias que faciliten la venta de la carne. Se realizó un estudio técnico de las granjas, complementado con entrevistas semiestructuradas a criadores seleccionados aleatoriamente, a informantes clave de los eslabones de producción y comercialización y visitas periódicas a puntos de venta. Uno de los aspectos típicos de la cunicultura en Tlaxcala es el predominio de un sistema extensivo, combinado con características de otros como el semiintensivo y empresarial. Algunas alternativas para mejorar la comercialización de la carne de conejo son: incrementar la eficiencia en su acopio, generar centros de distribución y puntos de venta, emplear economías de escala y diferenciar el producto que se expende al consumidor.

  16. COARCTATION OF AORTA AND TAKAYASU ARTERITIS FOR LSCS: ANAESTHESIA MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Rashmi

    2015-10-01

    Full Text Available Coarctation of aorta is a congenital disorder with 5-10% incidence. It occurs in about 1 in 10,000 births .It may remain asymptomatic till adulthood. During pregnancy, early gestational hypertension is the presenting sign. Difference in blood pressure in upper and lower limb is a characteristic finding of coarctation of aorta. Association of bicuspid aortic valve and ventricular septal defect is seen in 50% patients of coarctation. Major cardiovascular complications are infrequent but continue to be a source of concern for patients with coarctation who become pregnant. Coarctation of aorta commonly located at the junction of the arch of aorta and proximal descending aorta at the level of ductal structure, may be diagnosed for the first time during pregnancy. Dilatation and dissection of the aorta can lead to increased maternal mortality; significant stenosis is a contraindication to pregnancy. However, successful pregnancies have been reported in women with uncorrected coarctation if preconception risk stratification is done. Here is a case of LSCS with coarctation of aorta and Takayasu arteritis done successfully under epidural anaesthesia.

  17. [Endovascular repair for coarctation of the aorta in an adult].

    Science.gov (United States)

    Hayashi, Jun; Abe, Kazuo; Hata, Masaki; Nagano, Naoko; Hamasaki, Azumi; Suzuki, Kenji

    2013-09-01

    A 27-year-old woman with Turner's syndrome who underwent successful endovascular treatment for coarctation of the aorta is presented. She was admitted to our hospital complaining of upper extremity hypertension. Computed tomography revealed discrete stenosis of the proximal descending aorta and developed collateral circulation. After endovascular repair with a balloon expandable stent, her transcoarctation gradient fell from 44 mmHg preoperatively to less than 10 mmHg. She was discharged with no complications on the 7th postoperative day. Coarctation of the aorta in an adult patient could be safely and effectively managed by endovascular treatment.

  18. Calidad microbiol??gica de la carne de conejo y estimaci??n de la eficacia de algunos tratamientos tecnol??gicos de conservaci??n

    OpenAIRE

    Rodr??guez Calleja, Jos?? Mar??a

    2006-01-01

    232 p. En esta Tesis Doctoral se investigaron diferentes aspectos de la calidad microbiol??gica de la carne de conejo procedente de diferentes establecimientos (mataderos y establecimientos de venta). Tambi??n se determin?? la vida ??til de muestras de esta carne almacenada en tres tipos de atm??sferas modificadas (vac??o, 100% CO2 y mezcla comercial compuesta por 35% CO2:35% O2:30% N2) y cuando se almacenaba a refrigeraci??n en condiciones de aerobiosis. Por otro lado, se investig?? la pr...

  19. Evaluación de la terapia larval en el proceso de curación de heridas infectadas con Pseudomonas aeruginosa en conejos

    OpenAIRE

    Zapata, Cristina; Bello, Felio J; Rey, Mauricio; Castañeda, Adriana; González, Juliana; Acero, Víctor; Segura, Alexandra; Gaona, María A.; Ríos, Dora

    2010-01-01

    Introducción. Durante las últimas dos décadas,la terapia larval ha resurgido como una alternativa confiable y segura para la cura de úlceras cutáneas que no responden a los tratamientos convencionales. Objetivo. Evaluar el uso de las larvas de Lucilia sericata en el tratamiento de heridas infectadas con Pseudomonas aeruginosa en un modelo animal. Materiales y métodos. Se tomaron 12 conejos, los cuales fueron divididos al azar en 3 grupos homogéneos: al primero se le aplicó terapia larval, el ...

  20. Evaluación geométrica de meniscos frescos y conservados en glicerina al 98 %. Estudio en conejos (Oryctolagus cuniculus)

    OpenAIRE

    Diana Marcela Perez Berrio; Valery Jose Lancheros Suárez; Mastoby Miguel Martínez Martínez

    2014-01-01

    Los aloimplantes de meniscos se han utilizado como fuente de tejido a la hora de sustituirlos por roturas o daños irreparables. Para determinar posibles cambios o no por conservación se planteó como objetivo evaluar geométricamente meniscos frescos y conservados en glicerina al 98 %. Se utilizaron 15 meniscos mediales, provenientes de ocho conejos de raza nueva zelanda albina, separados en tres grupos: cinco meniscos frescos (GI), cinco meniscos conservados por ocho meses en glicerina al 98 %...

  1. Comportamiento diastólico durante la fase de "hipercontracción" post- isquémica en el miocardio atontado de conejo

    Directory of Open Access Journals (Sweden)

    G. E. Gonzalez

    2003-10-01

    Full Text Available El objetivo del estudio fue determinar si la fase de "hipercontracción" (HC que ocurre al comienzo de la reperfusión (R en el miocardio atontado, presenta alteraciones diastólicas, y si la R con bajo Ca2+ modifica las mismas. Corazones aislados e isovolúmicos de conejos fueron divididos en 2 grupos. El grupo 1 (G1, n=11 fue perfundido con Ringer ([Ca2+]=2mM y sujeto a 15 min de isquemia y 30 de R. El grupo 2 (G2, n=10 se reperfundió 10 min con Ringer ([Ca2+]=1mM que fue incrementado a 1.5 y 2 mM a los 30 min de R. Se evaluó: la contractilidad miocárdica (+dP/dtmáx, la rigidez diastólica (presión diastólica final (PDFVI y la relajación (t1/2 y cociente +P/-P. Al minuto de R la contractilidad se recuperó en G1 (76.88±5.37% vs valor preisquémico y fue atenuada en G2 (48.22±3.40% vs. valor preisquémico; PThe objective was to determine whether "hypercontraction" (HC that occurs at the beginning of reperfusion (R in stunned myocardium is accompanied by diastolic alterations and determine if the R with low Ca2+ Ringer's solution modifies these alterations. Isolated isovolumic rabbit hearts were divided into 2 groups. Group 1 (G1, n=11 was perfused with Ringer's solution ([Ca2+]=2mM and subjected to 15min of global ischemia and 30min of R. Group 2 (G2, n=10 was R during the first 10 min with ([Ca2+ ]=1mM, which was increased to 1.5 mM and 2 mM in the perfusate at 30 min of R. The left ventricular +dP/dtmáx, left ventricular end diastolic pressure (LVEDP (stiffness index, and relaxation rate (t1/2 and +P/-P ratio were measured, from the beginning of R every 10sec for 2min, and then at 5 and 30min. At 60 sec of R the +dP/dtmáx in G1 was increased (76,88±5,37% vs preischemic value and was attenuated in G2 (48,22±3,40%; P<0.05 vs G1. The LVEDP in G1 was increased early in the R, although it was negatively correlated with HC degree (r=-0.7477; p=0.008. This increase was attenuated in G2 (P<0.05 vs G1 at 60 secR. There was a delay in the

  2. Relación de la aterosclerosis de aorta y coronarias con la densidad mineral ósea lumbar y femoral: estudio en fallecidos

    OpenAIRE

    Solís Alfonso, Lesly

    2015-01-01

    Para demostrar la asociación existente entre las lesiones ateroscleróticas de aorta y arterias coronarias con la densidad mineral ósea de columna lumbar y fémur proximal se estudiaron 129 necropsias, realizando densitometría postmorten de columna lumbar y fémur proximal, definiendo los niveles de densidad mineral ósea (DMO) según T score en: normal, osteopenia y osteoporosis; seguido del examen patomorfológico y morfométrico de las tres coronarias epicárdicas principales y de aorta aplicando ...

  3. Respuesta productiva de conejos alimentados con forraje verde hidropónico de avena, como reemplazo parcial de concentrado comercial Productive response of rabbits fed with green hydroponic oats forage as partial replacement of commercial concentrate

    Directory of Open Access Journals (Sweden)

    Francisco Fabián Fuentes Carmona

    2011-04-01

    Full Text Available La respuesta productiva de conejos raza californiana alimentados con forraje verde hidropónico (FVH de avena como reemplazo parcial de concentrado comercial (CC, fue evaluada en condiciones de desierto en el norte de Chile. Se establecieron cinco tratamientos de alimentación, equivalentes a 0, 25, 50, 75 y 100% de reemplazo de la dieta diaria con FVH, el cual fue cosechado y utilizado directamente diez días después de la siembra. Cuarenta y cinco conejos destetados a los 31 días fueron evaluados en un diseño completamente al azar hasta alcanzar un peso de sacrificio de 2 kg de peso vivo. La calidad del FVH de avena fue considerada como buena, presentando similar valor nutritivo que el CC. Las variables evaluadas y sus respectivos rangos fueron: consumo de materia seca promedio (59.17 - 104.73 g/día, ganancia de peso vivo promedio (16.35 - 29.10 g/animal por día, conversión alimenticia promedio (3.31 - 3.93 kg MS/kg PV, tiempo de peso vivo a sacrificio (53 - 91 días, peso vivo final (1430 - 2044 g/animal, peso de la canal (1235 - 1385 g/animal y rendimiento de la canal (59.19 - 62.25%. El reemplazo de hasta 50% de la dieta base con FVH de avena no afectó significativamente (P The productive response of Californian rabbits fed with hydroponic green oats forage (HGOF as a partial replacement of commercial concentrate (CC was evaluated under desert conditions in northern Chile. Five treatments were established as follow: 0, 25, 50, 75 and 100% replacement of daily diet with HGOF, which was harvested and used directly at 10 days after sowing. Forty-five rabbits weaned at 31 days were evaluated in a completely randomized design until slaughter weight of 2.0 kg. HGOF quality was considered as good, presenting similar nutritional value to CC. The variables assessed and range values were: average dry matter intake (59.17-104.73 g/d, average weight gain (16.35-29.10 g/ rabbit for day, feed conversion average (3.31-3.93 kg DM/ kg LW, time of

  4. Magnetic resonance imaging of congenital abnormalities of the thoracic aorta

    Energy Technology Data Exchange (ETDEWEB)

    Soler, R.; Rodriguez, E.; Requejo, I.; Fernandez, R. [Department of Radiology, Hospital Juan Canalejo, La Coruma (Spain); Raposo, I. [Department of Pediatric Cardiology, Hospital Juan Canalejo, La Coruna (Spain)

    1998-05-01

    This article outlines the ability of MR imaging in the detection and presurgical evaluation of congenital abnormalities of the thoracic aorta (CATA). Congenital abnormalities of the thoracic aorta may be found incidentally on chest radiographs in patients without symptoms, or it can be associated with clinical findings which are very variable depending on the association with congenital cardiac malformations or vascular ring. When CATA is suspected as the cause of anomalies in the mediastinum in asymptomatic patients, confirmation of the abnormality should be by MR imaging allowing precise evaluation of the thoracic aorta and origin of the principal arteries. When CATA is considered because clinical findings indicate coarctation of the aorta, vascular ring or associated cardiac disorder, evaluation with ultrasound can be complemented by MR, which in most cases will replace the diagnostic catheterization. (orig.) With 12 figs., 24 refs.

  5. Endovascular management of recurrent adult coarctation of the aorta.

    Science.gov (United States)

    Kpodonu, Jacques; Ramaiah, Venkatesh G; Rodriguez-Lopez, Julio A; Diethrich, Edward B

    2010-11-01

    Traditional open surgical repair has proven to be an effective treatment for the management of primary and recurrent coarctation of the thoracic aorta. Potential complications at short-term and long-term follow-up have included recurrent coarctation, hypertension, premature coronary artery disease, cerebrovascular disease, and anastomotic pseudoaneurysm. Endovascular repair of recurrent coarctation of the thoracic aorta offers a less invasive treatment approach in potential high-risk surgical patients.

  6. Surgical treatment of penetrating atherosclerotic ulcer of the descending aorta

    Directory of Open Access Journals (Sweden)

    Kovačević Pavle

    2013-01-01

    Full Text Available Introduction. The term “penetrating atherosclerotic ulcer” (PAU of the aorta describes the condition in which ulceration of an aortic atherosclerotic lesion penetrates the internal elastic lamina into media. PAU is a high-risk lesion due to its deleterious effects on the integrity of aortic wall, with potentially fatal outcome. Case report. A patient with intensive, sharp chest pain irradiating to the back but with no signs of myocardial ischemia on an electrocardiogram was referred to our hospital. Transthoracic echocardiography showed no pathological changes of the ascending aorta. However, multislice computed tomography (CT showed an aortic ulcer with varying degree of the subadventitial hemorrhage in the region of the thoracic aorta at the level of Th 8-9. Due to imminent rupture of the penetrating aortic ulcer, the patient was promptly prepared for surgery. A 15 cm long subadventitial hematoma was found intraoperatively in the right posterolateral aspect of the descending aorta, 5 cm above the diaphragm and 7 cm below the origin of the left subclavial artery. The affected segment of the aorta was resected, followed by an inlay aortic reconstruction with a Dacron tube graft of 24 mm. Control CT revealed satisfactory reconstruction of the descending aorta. Conclusion. PAU is a rare, but potentially fatal disease. Open surgery in patients with PAU is an effective treatment strategy, although endovascular treatment options are emerging.

  7. Spatial and Temporal Variations in Streamflow and Dissolved Solids in the Rio Grande from Del Norte, Colorado, to El Paso, Texas, 1993-95

    Science.gov (United States)

    Moore, S. J.; Anderholm, S. K.

    2002-12-01

    Data collected as part of the Rio Grande Valley National Water Quality Assessment Program were used to evaluate spatial and temporal variations in streamflow and the concentration of dissolved solids at selected sites on the Rio Grande from Del Norte, Colorado, to El Paso, Texas, for the period of April 1993 to September 1995. Dissolved solids loads, which were estimated by a multivariate linear regression model (ESTIMATOR2000), are also presented and discussed. Spatial and temporal variations in streamflow, dissolved solids concentrations, and dissolved solids loads were used to evaluate how surface-water and ground-water inflows to and outflows from the Rio Grande affect dissolved solids along the river. Streamflow decreases from Del Norte, Colorado, to the mouth of the Conejos River because of diversions for irrigation. Streamflow increases from the mouth of the Conejos River to Otowi Bridge because of surface-water inflows (from the Conejos River, the Chama River, and other tributaries) and ground-water inflow in northern New Mexico. Streamflow decreases downstream from Otowi Bridge because outflows (due to agricultural use, leakage to ground water, and evapo-transpiration) are greater than inflows. Dissolved solids concentrations generally increase in the downstream direction; however, dissolved solids concentrations decrease between the mouth of the Conejos River and Otowi Bridge due to surface-water inflows from the Conejos and the Chama Rivers and ground-water inflows in northern New Mexico. In several reaches of the Rio Grande, decreasing streamflow and increasing dissolved solids loads indicate the presence of inflows with large dissolved solids concentrations (relative to those of the Rio Grande immediately upstream from that inflow); this occurs (1) between Del Norte, Colorado, and the mouth of Trinchera Creek, near Lasauses, Colorado (2) between Otowi Bridge and San Marcial, New Mexico, and (3) between Leasburg, New Mexico, and El Paso, Texas

  8. Morphological Evidence of Telocytes in Mice Aorta

    Directory of Open Access Journals (Sweden)

    Hong-Qi Zhang

    2015-01-01

    Full Text Available Background: Telocytes (TCs are a novel type of interstitial cells, which have been recently described in a large variety of cavitary and noncavitary organs. TCs have small cell bodies, and remarkably thin, long, and moniliform prolongations called telopodes (Tps. Until now, TCs have been found in various loose connective tissues surrounding the arterioles, venules, and capillaries, but as a histological cellular component, whether TCs exist in large arteries remains unexplored. Methods: TCs were identified by transmission electron microscope in the aortic arch of male C57BL/6 mice. Results: TCs in aortic arch had small cell bodies (length: 6.06-13.02 μm; width: 1.05-4.25 μm with characteristics of specific long (7.74-39.05 μm, thin, and moniliform Tps; TCs distributed in the whole connective tissue layer of tunica adventitia: TCs in the innermost layer of tunica adventitia, located at the juncture between media and adventitia, with their long axes oriented parallel to the outer elastic membrane; and TCs in outer layers of tunica adventitia, were embedded among transverse and longitudinal oriented collagen fibers, forming a highly complex three-dimensional meshwork. Moreover, desmosomes were observed, serving as pathways connecting neighboring Tps. In addition, vesicles shed from the surface of TCs into the extracellular matrix, participating in some biological processes. Conclusions: TCs in aorta arch are a newly recognized complement distinct from other interstitial cells in large arteries, such as fibroblasts. And further biologically functional correlations need to be elucidated.

  9. Morphological Evidence of Telocytes in Mice Aorta

    Institute of Scientific and Technical Information of China (English)

    Hong-Qi Zhang; Shan-Shan Lu; Ting Xu; Yan-Ling Feng; Hua Li; Jun-Bo Ge

    2015-01-01

    Background:Telocytes (TCs) are a novel type of interstitial cells,which have been recently described in a large variety of cavitary and noncavitary organs.TCs have small cell bodies,and remarkably thin,long,and moniliform prolongations called telopodes (Tps).Until now,TCs have been found in various loose connective tissues surrounding the arterioles,venules,and capillaries,but as a histological cellular component,whether TCs exist in large arteries remains unexplored.Methods:TCs were identified by transmission electron microscope in the aortic arch of male C57BL/6 mice.Results:TCs in aortic arch had small cell bodies (length:6.06-13.02 μm; width:1.05-4.25 μm) with characteristics of specific long (7.74-39.05 μm),thin,and moniliform Tps; TCs distributed in the whole connective tissue layer of tunica adventitia:TCs in the innermost layer of tunica adventitia,located at the juncture between media and adventitia,with their long axes oriented parallel to the outer elastic membrane; and TCs in outer layers oftunica adventitia,were embedded among transverse and longitudinal oriented collagen fibers,forming a highly complex three-dimensional meshwork.Moreover,desmosomes were observed,serving as pathways connecting neighboring Tps.In addition,vesicles shed from the surface of TCs into the extracellular matrix,participating in some biological processes.Conclusions:TCs in aorta arch are a newly recognized complement distinct from other interstitial cells in large arteries,such as fibroblasts.And further biologically functional correlations need to be elucidated.

  10. Intramural aortic hematomas; Intramurale Haematome der Aorta

    Energy Technology Data Exchange (ETDEWEB)

    Raab, B.W.; Vosshenrich, R.; Fischer, U.; Funke, M.; Grabbe, E. [Goettingen Univ. (Germany). Abt. fuer Roentgendiagnostik

    2001-08-01

    Intramural hematomas (IMH) are regarded as a hemorrhage into the aortic wall. In general a traumatic form can be differentiated from a spontaneous non-traumatic. There is a predisposition of IMH with arterial hypertension and mesoectodermal dysplastic syndromes. The diagnosis is established with the clinical presentation in combination with the findings of different imaging modalities. Acute and subacute discomfort associated with a tendency of collaps are considered as typical presenting complaints. A semicircular or concentric thickening of the aortic wall with the absence of blood flow or a dissection membran are typical findings in transesophageal echocardiography, computed tomography and magnetic resonance tomography. From a differential diagnostic point of view a distinction from atherosclerotic wall changes, intraluminal thrombi and inflammatory aortic diseases is essential. The IMH is considered as an early presentation of aortic dissection, put into and treated according to the Stanford classification. In the course of natural history an IMH can disappear, rupture or progress into a classic aortic dissection. (orig.) [German] Das intramurale Haematom (IMH) ist eine Einblutung in die Aortenwand. Grundsaetzlich kann zwischen traumatischer Genese und einer atraumatischen spontanen Form unterschieden werden. Praedisponierend sind arterielle Hypertension und mesoektodermale Dysplasiesyndrome. Die Diagnose ergibt sich aus der Klinik und den Befunden in den bildgebenden Verfahren. Zu den klinischen Symptomen zaehlen akut oder subakut auftretende Schmerzen, assoziiert mit einer Kollapsneigung. Typische Befunde in der transoesophagealen Echokardiographie, der Computer- oder der Magnetresonanztomographie sind eine halbmondfoermige oder konzentrische Wandverdickung der Aorta ohne Nachweis von Blutfluss oder einer Dissektionsmembran mit Dichtewerten bzw. Signalintensitaeten in Abhaengigkeit vom Alter der Einblutung. Differenzialdiagnostisch ist eine Abgrenzung

  11. Oclusión de la aorta abdominal infrarrenal. Reconstrucción endovascular con stent

    Directory of Open Access Journals (Sweden)

    Carlos Fernández-Pereira

    2008-01-01

    Full Text Available Introducción La oclusión total de la aorta abdominal es de presentación poco frecuente y afecta más a menudo a mujeres de edad mediana con antecedentes de tabaquismo y dislipidemia. El punto de partida de la terapéutica endovascular en la aorta fue la angioplastia en las arterias ilíacas y fue progresando desde el balón hasta la colocación de stents.ObjetivoComunicar nuestros resultados inmediatos y el seguimiento a mediano plazo de pacientes con oclusión de la aorta abdominal tratadas con stents por vía endovascular.Material y métodosDesde octubre de 1998 a mayo de 2005 en nuestro servicio se trataron 5 pacientes de sexo femenino por oclusión total de la aorta abdominal, con síntomas de claudicación grave de ambos miembros inferiores. Los procedimientos se realizaron con anestesia local y sedación. Por vía femoral, se intenta recanalizar con las cuerdas de Whooley o hidrófila Glidewire. Posteriormente se realiza un angiograma abdominal e intercambio por cuerda Amplatz con la cual se avanza el balón para realizar las dilataciones antes de implantar el stent. Las pacientes con lesiones ilíacas también se trataron con stent. El índice tobillo-brazo era de 0,71. El promedio de hospitalización fue de 2 días. Al alta se indicaron clopidogrel y aspirina como medicación antiplaquetaria, excepto la primera paciente (ticlopidina y aspirina. El seguimiento fue clínico y por ecografía Doppler color a la semana, al mes, a los 6 meses y a los 12 meses.ResultadosLas pacientes eran de sexo femenino, con antecedentes de tabaquismo y dislipidemia. Todos los procedimientos fueron técnicamente exitosos, con mejoría del índice tobillo-brazo a 0,98. Una paciente presentó un hematoma inguinal en el sitio de punción, con buena evolución posterior. En el seguimiento alejado clínico y por ultrasonido se observó una permeabilidad de la aorta del 100%, con estenosis en una paciente tratada a nivel de la arteria ilíaca en el segmento no

  12. Reparación ósea mediante aloimplantes sometidos a diferentesmétodos de conservación en conejos Allogeneic bone grafts treated with different conservation methodsfor bone repair in rabbits

    Directory of Open Access Journals (Sweden)

    G. Dasso

    1998-01-01

    Full Text Available Debido a las limitantes de los implantes de hueso de origen autogénico y a la ineficiencia de los implantes de hueso fresco de origen alogénico ha sido necesario incursionar en el área de los implantes de hueso alogénico procesados. Con este objetivo se utilizaron 27 conejos raza blanco neozelandés de 3 a 5 meses de edad, quienes recibieron los diferentes tipos de aloimplantes de hueso esponjoso (desproteinizados, congelados o hervidos para evaluar el grado de reparación de una lesión previamente realizada en la tibia. Los animales fueron sacrificados a las dos, cuatro y ocho semanas postcirugía y la evaluación se realizó a través de cortes histológicos. Determinándose que a las dos semanas post-cirugía no hubo mayor diferencia entre los distintos grupos analizados, pero sí lo hubo a las cuatro y ocho semanas post-cirugía, donde se observó claramente una mayor eficiencia de los implantes desproteinizados. Esto se debe a que el hipoclorito de sodio destruye los elementos antigénicos presentes en el implante, lo que disminuye las probabilidades de rechazo por parte del huésped y facilita la llegada de células indiferenciadas que se diferencian a osteoblastos formando así hueso neoformado, por lo tanto, esto se refleja en un mayor grado de reparación en comparación con los implantes tratados por congelación y más aún si lo comparamos con los aloimplantes tratados por ebullición. Esta información puede ser de gran utilidad para la implementación de un banco de huesos destinado a corregir lesiones del sistema esqueléticoDue to limitations in the availability of autogeneic bone and to the inefficiency of the fresh allogeneic bone grafts, it has been necessary to evaluate the use of allogeneic processed bone. Therefore, the ability of three procedures -freezing, boiling and desproteinization of allogeneic bone- to repair experimentally created defects in rabbit tibia was tested. Tibia, 2, 4 and 8 weeks after surgery were

  13. Right thoracotomy approach for repair of recurrent or complex coarctation of the aorta using an extra-anatomic ascending aorta to descending aorta bypass graft off-pump.

    Science.gov (United States)

    Tabry, Imad F; Zachariah, Zachariah P

    2013-01-01

    A previously described but rarely used surgical technique for the repair of complex or recurrent coarctation of the aorta through a right thoracotomy approach is presented in detail. It has the advantages of being simple and avoiding left chest re-entry, median sternotomy and cardiopulmonary bypass altogether.

  14. Increased RhoA translocation in aorta of diabetic rats

    Institute of Scientific and Technical Information of China (English)

    Jiping TANG; Ikuyo KUSAKA; Amber R MASSEY; Shadon ROLLINS; John H ZHANG

    2006-01-01

    Aim: To analyze RhoA expression and activation in the aorta of diabetic rats. Methods: Male SD rats (n=70) were divided into 2 groups: the diabetic group and the control group. Diabetes was induced by intravenous injection of streptozotocin (55 mg/kg). The Rats were studied 3 weeks after the induction of diabetes. Western blotting was used to measure the expression and activation of Rho. Results: Heart rate was measured 24 h/d; it decreased by 58±13 beats/min in the diabetic rats. Isometric tension showed that the contraction of diabetic aorta was significantly reduced compared with that of control aorta when stimulated by KCl and serotonin. The relaxation of the diabetic aorta was reduced when stimulated by acetylcholine. An enhanced RhoA translocation in the aortic tissues of diabetic rats was determined by a 90% increase in membrane-bound RhoA, indicating that the activation of RhoA is markedly increased in the diabetic aorta. Conclusion: Our data suggest that upregulated RhoA could be involved in the vascular dysfunction of diabetic rats.

  15. Tenascin C protects aorta from acute dissection in mice

    Science.gov (United States)

    Kimura, Taizo; Shiraishi, Kozoh; Furusho, Aya; Ito, Sohei; Hirakata, Saki; Nishida, Norifumi; Yoshimura, Koichi; Imanaka-Yoshida, Kyoko; Yoshida, Toshimichi; Ikeda, Yasuhiro; Miyamoto, Takanobu; Ueno, Takafumi; Hamano, Kimikazu; Hiroe, Michiaki; Aonuma, Kazutaka; Matsuzaki, Masunori; Imaizumi, Tsutomu; Aoki, Hiroki

    2014-02-01

    Acute aortic dissection (AAD) is caused by the disruption of intimomedial layer of the aortic walls, which is immediately life-threatening. Although recent studies indicate the importance of proinflammatory response in pathogenesis of AAD, the mechanism to keep the destructive inflammatory response in check is unknown. Here, we report that induction of tenascin-C (TNC) is a stress-evoked protective mechanism against the acute hemodynamic and humoral stress in aorta. Periaortic application of CaCl2 caused stiffening of abdominal aorta, which augmented the hemodynamic stress and TNC induction in suprarenal aorta by angiotensin II infusion. Deletion of Tnc gene rendered mice susceptible to AAD development upon the aortic stress, which was accompanied by impaired TGFβ signaling, insufficient induction of extracellular matrix proteins and exaggerated proinflammatory response. Thus, TNC works as a stress-evoked molecular damper to maintain the aortic integrity under the acute stress.

  16. Avaliação do gradiente pressórico aorto-radial em pacientes submetidos à intervenção cirúrgica com circulação extracorpórea Evaluación del gradiente presórico aorto-radial en pacientes sometidos a la intervención quirúrgica con circulación extracorpórea Evaluation of the aorta-to-radial artery pressure gradient in patients undergoing surgery with cardiopulmonary bypass

    Directory of Open Access Journals (Sweden)

    Maria José Carvalho Carmona

    2007-12-01

    presión aórtica durante revascularización del miocardio (RM con CEC y su correlación con la resistencia vascular sistémica. MÉTODO: Después de la aprobación por el Comité de Ética hospitalaria, 16 pacientes sometidos a la RM con CEC hipotérmica fueron estudiados. Presiones sistólica, diastólica y media fueron obtenidas en la raíz de la aorta y en la arteria radial, a través de catéteres específicos. Débito cardíaco se obtuvo usando catéter de arteria pulmonar o directamente de la máquina de CEC y Resistencia Vascular Sistémica indexada (RVSi fue calculada en los momentos pre-CEC, inicio de la CEC, después de la última RM, al final de la CEC y pos-CEC. El análisis estadístico se realizó a través de Análisis de Variancia para medidas repetidas y correlación de orden de Spearman y el nivel de significancia se estableció en 0,05. RESULTADOS: Después del inicio de la CEC, la presión arterial radial fue sistemáticamente menor que la presión aórtica en 3 a 5 mmHg. Se observó correlación significativa entre el gradiente medio de presión aorto-radial y la RVSi solamente después de la ultima RM, correspondiendo al calentamiento del paciente (Rho = 0,67, p = 0,009. CONCLUSIONES: La medida de presión en la arterial radial subestimó sistemáticamente la presión arterial en la raíz de la aorta después de la CEC y la RVSi no suministró estimación puntual de la magnitud del gradiente de presión aorto-radial.BACKGROUND AND OBJECTIVES: Several studies have demonstrated a significant difference between the aortic and radial artery pressures in patients on cardiopulmonary bypass (CPB. The objectives of this study were to evaluate the behavior of the aorta-to-radial artery pressure gradient during myocardial revascularization (MR with CPB and its correlation with the systemic vascular resistance. METHODS: After approval by the Ethics Committee of the hospital, 16 patients undergoing MR with hypothermic CPB were studied. Systolic, diastolic and

  17. - Evaluación de la irritabilidad oftálmica de cremas cosméticas mediante un método in vitro en sustitución de la prueba en conejos (Ophthalmic irritability evaluation of cosmetic creams by in vitro method in substitution of the test in rabbits

    Directory of Open Access Journals (Sweden)

    Yisel González Madariaga

    2006-03-01

    Full Text Available Resumen Se evaluó la irritabilidad oftálmica de tres cremas cosméticas desarrolladas en el Laboratorio Provincial de Cosméticos de Villa Clara (Cuba. El ensayo se realizó mediante la técnica alternativa in vitro en membrana corioalantoidea de embriones de pollo (HET-CAM, hen´s egg test chorioallantoic membrane en sustitución de la técnica habitual de irritabilidad oftálmica en conejos (Draize y en correspondencia con el Protocolo 47 de INVITOX (In Vitro Toxicology. En las condiciones del ensayo los cosméticos evaluados se clasificaron como no irritantes. Ophthalmic irritability of three cosmetic creams developed in the Provincial Laboratory of Cosmetics of Villa Clara (Cuba was evaluated. The assay was carried out by the alternative in vitro technique in chorioallantoic membrane of chicken embryos (HET-CAM, hen´s egg test chorioallantoic membrane in substitution of the habitual technique of ophthalmic irritability in rabbits (Draize and in correspondence with the Protocol 47 of INVITOX (In Vitro Toxicology. Under the conditions of the rehearsal the evaluated cosmetics were classified as not irritating. Keys words:

  18. Demonstration of coarctation of the aorta by magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Amparo, E.; Higgins, C.B.; Shafton, E.P.

    1984-12-01

    The physical findings in coarctation of the aorta are sufficiently characteristic to allow a reasonably accurate clinical diagnosis. The preoperative evaluation has been accomplished by catheterization, aortography, intravenous digital subtraction angiography, computed tomography (CT), and two-dimensional (2D) echocardiography. The authors report a case of coarctation of the aorta clinically suspected in a 29-year-old man. Magnetic resonance imaging (MRI) was the initial preoperative imaging technique. In retrospect, it provided sufficient information for preoperative evaluation so that other imaging techniques would not have been required.

  19. Posible superfetación en una coneja raza NZB (Oryctolagus cuniculus) concomitante a retraso del desarrollo intrauterino (RDIU)

    OpenAIRE

    Tena, Eduardo; Hernández, Braulio; Ibáñez, Alejandra; Reyes, Sergio

    2013-01-01

    Los trastornos reproductivos del conejo son complejos y numerosos incluyendo rarezas como la superfetación (SF). Se describe un posible caso de sf descubierto accidentalmente, asociado a distocia en una coneja de la raza nzb, que sufre de severa hemorragia vaginal, postración, hipotermia y no reactiva al estímulo. Durante la palpación, numerosos fetos fueron detectados en ambos cuernos uterinos sin respuesta a la manipulación obstétrica para extracción. La cesárea urgente reveló seis producto...

  20. Endovascular covered stent treatment for descending aorta pseudoaneurysm following coarctation of the aorta repair in an infant.

    Science.gov (United States)

    Takawira, Farirai F; Sinyangwe, Greenwood; Mooloo, Rene

    2010-12-01

    The development of a pseudoaneurysm is a rare complication following repair of a coarctation of the aorta. Surgical management of pseudoaneurysms is associated with high morbidity and mortality. We describe the successful endovascular deployment of a covered stent in a sick infant with a descending aorta pseudoaneurysm, following the repair of an aortic coarctation. We highlight the challenges we encountered. Endovascular repair is a safe palliative alternative to re-do open surgery in unstable infants with large pseudoaneurysms following aortic coarctation repair. The role of endovascular stents as the final definitive therapy will remain limited by the deployable, small-size stents in small, growing children.

  1. Evaluación cardiorrespiratoria de conejos (Oryctolagus cuniculus anestesiados con una combinación de tramadol, acepromacina, xilazina y ketamina

    Directory of Open Access Journals (Sweden)

    JJ Pérez-Rivero

    2014-01-01

    Full Text Available Los conejos son considerados animales difíciles de anestesiar, debido a sus peculiaridades anatómicas y fisiológicas. Durante la anestesia general se presenta una mortalidad superior al 5%, además las combinaciones anestésicas utilizadas pocas veces incluyen analgésicos de manera transoperatoria. 25 conejos Nueva Zelanda clínicamente sanos fueron anestesiados con la combinación de ketamina (50mg/kg, xilacina (5mg/kg, acepromacina (0,5 mg/ kg, por vía intramuscular, 10 minutos después se aplicó tramadol (5 mg/kg por vía endovenosa. Se evaluó frecuencia cardiaca, respiratoria y oximetría antes de la aplicación de la anestesia al minuto"0" y posteriormente cada 10 minutos hasta el minuto 60. La frecuencia cardiaca y respiratoria tuvieron una diferencia significativa (P < 0,05 entre el minuto "0" y el minuto "10" a partir de este momento no existen cambios significativos durante los restantes 50 minutos. La frecuencia cardiaca promedio fue de 154 ± 28 latidos por minuto y la frecuencia respiratoria promedio fue de 63 ± 33 respiraciones por minuto durante el procedimiento. La oximetría promedio fue de 88 ± 8 %, se encontró diferencia significativa sólo en el minuto 40 de la anestesia. Aparentemente el protocolo anestésico a base de tramadol, acepromacina, xilazina y ketamina es seguro a las dosis utilizadas para la enseñanza de la cirugía, en donde las FC, FR y la Ox aparentemente se comportan con estabilidad, sin embargo, se recomienda suplementar oxigeno durante la anestesia.

  2. Isolated Anomalous Origin of Left Pulmonary Artery From the Descending Aorta: An Embryologic Ambiguity.

    Science.gov (United States)

    Gnanappa, Ganesh Kumar; Laohachai, Karina; Orr, Yishay; Ayer, Julian

    2016-11-01

    Anomalous origin of a branch pulmonary artery from the aorta is a rare malformation, accounting for 0.12% of all congenital heart defects. Anomalous origin of the left pulmonary artery from the aorta (ALPA) constitutes a small proportion of these cases. ALPA has been reported to arise from the ascending aorta with various embryologic postulates. We report a case of isolated ALPA arising from the descending aorta in association with a patent ductus arteriosus, to emphasize its embryologic ambiguity.

  3. Segmentation of the thoracic aorta in noncontrast cardiac CT images.

    Science.gov (United States)

    Avila-Montes, Olga C; Kurkure, Uday; Nakazato, Ryo; Berman, Daniel S; Dey, Damini; Kakadiaris, Ioannis A

    2013-09-01

    Studies have shown that aortic calcification is associated with cardiovascular disease. In this study, a method for localization, centerline extraction, and segmentation of the thoracic aorta in noncontrast cardiac-computed tomography (CT) images, toward the detection of aortic calcification, is presented. The localization of the right coronary artery ostium slice is formulated as a regression problem whose input variables are obtained from simple intensity features computed from a pyramid representation of the slice. The localization, centerline extraction, and segmentation of the aorta are formulated as optimal path detection problems. Dynamic programming is applied in the Hough space for localizing key center points in the aorta which guide the centerline tracing using a fast marching-based minimal path extraction framework. The input volume is then resampled into a stack of 2-D cross-sectional planes orthogonal to the obtained centerline. Dynamic programming is again applied for the segmentation of the aorta in each slice of the resampled volume. The obtained segmentation is finally mapped back to its original volume space. The performance of the proposed method was assessed on cardiac noncontrast CT scans and promising results were obtained.

  4. Mineralization of human aortas with coarctation: quantitative electron probe microanalysis

    Energy Technology Data Exchange (ETDEWEB)

    Krefting, E.R.; Roehrig, T.; Broecker, W.; Anyanwu, E.; Schlake, W.; Dittrich, H.; Hoehling, H.J.

    1982-01-01

    Aortas with coarctation (isthmus stenosis) are obviously an ideal model to investigate pressure dependent changes of the aorta, as one can compare the proximal region (high pressure) with the distal region (low pressure). 7 aortas of patients aged from 2 months to 54 years were investigated. The concentrations of Na, Mg, P, S, C1, K, and Ca were determined by electronprobe microanalysis. Ca and P are constituent parts of the developing mineral and are mainly discussed. The Ca/P ratio (by weight) is about 0.3 in the unmineralized and about 2 in the mineralized tissue. Mineralization is demonstrated by a parallel increase of Ca, P, and the Ca/P ratio. Enrichments of Ca and P are found above all in a subintimal band. Usually they occur proximally and distally, but are much more pronounced proximally. Even in the aorta of a 2 month old infant enrichments were found proximally, but not distally. Thus mineral deposits occur very early in regions of hypertension. The differences between the proximal and distal region may demonstrate the influence of blood pressure on vascular mineralization. The mineralization starts in small compartments, which increase in size and number in the process of mineralization. Mineralized regions could often be localized by cathodoluminescence. But to demonstrate and localize the initial mineral deposits and to quantify element contents, electronprobe microanalysis became indispensable.

  5. Ischemic colitis complicating reconstruction of the abdominal aorta

    DEFF Research Database (Denmark)

    Schroeder, T V; Christoffersen, J K; Andersen, J

    1985-01-01

    A review of 23 patients with ischemic colitis after surgical treatment of the abdominal aorta disclosed a pathogenetic heterogeneous finding. Ligation of the inferior mesenteric artery, abolished collateral blood supply or nonocclusive low flow state, or both, was a common feature. An incidence...

  6. Surgical exclusion of postsurgical pseudoaneurysm of the ascending aorta

    Directory of Open Access Journals (Sweden)

    Ramachandra Barik

    2014-01-01

    Full Text Available Pseudoaneurysm of ascending aorta after cardiac surgery is rare in children. We report a case of successful surgical exclusion of ascending aortic pseudoaneurysm in a 15-year-old boy. The neck of the aneurysm was in close proximity to the right coronary artery (RCA.

  7. Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta.

    Science.gov (United States)

    Campos, M G; Oropeza, M V; Villanueva, T; Aguilar, M I; Delgado, G; Ponce, H A

    2000-06-08

    Xanthorrhizol, a bisabolene isolated from the medicinal plant Iostephane heterophylla, was assayed on rat thoracic aorta rings to elucidate its effect and likely mechanism of action, by measuring changes of isometric tension. Xanthorrhizol (1, 3, 10, 30 and 100 microg/mL) significantly inhibited precontractions induced by KCI-; (60mM), noradrenaline (10(-6) M) or CaCl2 (1.0 mM). Increasing concentrations of external calcium antagonized the inhibitory effect on KCl-induced contractions. The vasorelaxing effect of xanthorrhizol was not affected by indomethacin (10 microM) or L-NAME (100 microM) in intact rat thoracic aorta rings precontracted by noradrenaline, which suggested that the effect was not mediated through either endothelium-derived prostacyclin (PGI2) or nitric oxide release from endothelial cells. Endothelium removal did not affect the relaxation induced by xanthorrhizol on rat thoracic aorta rings, discarding the participation of any substance released by the endothelium. Xanthorrhizol inhibitory effect was greater on KCI- and CaCl2-induced contractions than on those induced by noradrenaline. Xanthorrhizol inhibitory effect in rat thoracic aorta is likely explained for interference with calcium availability by inhibiting calcium influx through both voltage- and receptor-operated channels.

  8. The novel phenylpropiophenone derivates induced relaxation of isolated rat aorta.

    Science.gov (United States)

    Ivković, B; Vladimirov, S; Novaković, R; Cupić, V; Heinle, H; Gojković-Bukarica, L

    2012-07-01

    Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.

  9. CFU-S(11) activity does not localize solely with the aorta in the aorta-gonad-mesonephros region

    NARCIS (Netherlands)

    M.F.T.R. de Bruijn (Marella); M.C. Peeters (Marian); T. Luteijn; P. Visser (Pim); N.A. Speck; E.A. Dzierzak (Elaine)

    2000-01-01

    textabstractThe aorta-gonad-mesonephros (AGM) region is a potent hematopoietic site in the midgestation mouse conceptus and first contains colony-forming units-spleen day 11 (CFU-S(11)) at embryonic day 10 (E10). Because CFU-S(11) activity is present in the AGM region b

  10. Contractile reaction of isolated frog aorta after X-irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Michailov, M.C.; Prechter, I.; Greimel, H.; Welscher, U.E.

    1983-07-01

    The action of X-rays (50 kV, filtered by 0.3 mm Al) on helical strip of frog aorta (rana esculenta) has been investigated. The isolated preparations have a stable basal tone and are radio-sensitive to X-rays which induce reversible, dose-dependent, contractile responses. After repeated irradiational tachyphylaxis appears. The threshold doses are about 250 R at 3 to 6 kR/min, antiadrenergic (phentolamine, propranolol), anticholinergic (atropin), antihistaminic (Neo-Bridal) and serotoninergic (Deseril) drugs have no visible influence on the X-ray induced reaction, i.e. these action mechanisms of the irradiation-induced contraction do not seem probable. Theophylline and cAMP inhibit the X-ray contraction probably non-specifically. Indometacin also inhibits the X-ray contraction: this suggests participation of prostaglandin-mechanism on the contraction of frog aorta after irradiation.

  11. The AORTA Reasoning Framework - Adding Organizational Reasoning to Agents

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt

    is a practical component (founded in logic) that enriches intelligent agents with organizational reasoning capabilities. We take the agent’s perspective by devising a component that integrates with the agent’s usual reasoning capabilities in a non-intrusive way. This results in agents that are both organization...... a generic framework that allows different kinds of agents to reason about different kinds of organizations. We present our results in three main parts. In the first part, we present the theoretical foundations for the AORTA framework, which consists of semantics of norms, an organizational metamodel......, and the AORTA reasoning component. The reasoning component is characterized by being completely decoupled from the cognitive agent, by its automated reasoning about norms and organizational options, and by the reasoning rules specified by the designer to act upon norms and options. We specify the reasoning...

  12. Mycotic aneurysm of the thoracic aorta presenting as pneumonia

    Energy Technology Data Exchange (ETDEWEB)

    Mengozzi, E. [Dept. of Radiology, Maggiore Hospital, Bologna (Italy); Sartoni Galloni, S. [Dept. of Radiology, San Salvatore Hospital, Bologna (Italy); Giovannini, G. [Dept. of Paediatrics, Maggiore Hospital, Bologna (Italy); Bronzetti, G. [Dept. of Paediatric Cardiology, Sant' Orsola-Malpighi University Medical Centre, Bologna (Italy)

    2001-07-01

    Mycotic aneurysms of the thoracic aorta rarely occur in children. We report an unusual case of a mycotic aneurysm of the descending aorta in a 4-year-old boy presenting with respiratory tract infection, which was rapidly complicated by atelectasis of the left lung. The patient's mycotic aortic aneurysm was diagnosed by contrast-enhanced spiral CT, whereas conventional chest radiographs did not detect its presence. An unsuspected mild aortic coarctation was also diagnosed at the time of admission. This case demonstrates that an aortic aneurysm may clinically and radiologically manifest itself with respiratory tract infection and atelectasis and that contrast-enhanced spiral CT is a fast and powerful tool for establishing the diagnosis. (orig.)

  13. THE COURSE OF DISSECTING ANEURYSM OF THE AORTA

    Directory of Open Access Journals (Sweden)

    N. A. Kosheleva

    2016-01-01

    Full Text Available Research objective. To define features of a course of dissecting aortic aneurysm now.Materials and methods. 11 clinical records of the patients with the established diagnosis of dissecting aortic aneurysm who have come to Regional clinical hospital of Saratov for 2015 are analysed.Results. Along with traditional risk factors, such as the male, existence of arterial hypertension are revealed also additional risk factors, in particular, regular heavy lifting. Gender features in localization of dissecting aortic aneurysm are defined: at men more often of dissecting aortic aneurysm of an aorta is localized in the abdominal aorta, at women in the thoracic region.Conclusions. Additional risk factor of stratification of dissecting aortic aneurysm in the thoracic region at women is the systematic raising of weights.

  14. Hemodynamics of patient-specific aorta-pulmonary shunt configurations

    OpenAIRE

    Pekkan, Kerem; Pişkin, Senol; Altın, H. Fırat; Yıldız, Okan; Bakır, İhsan

    2017-01-01

    Optimal hemodynamics in aorta-pulmonary shunt reconstruction is essential for improved post-operative recovery of the newborn congenital heart disease patient. However, prior to in vivo execution, the prediction of post-operative hemodynamics is extremely challenging due to the interplay of multiple confounding physiological factors. It is hypothesized that the post-operative performance of the surgical shunt can be predicted through computational blood flow simulations that consider patient ...

  15. Aberrant vertebral artery originating from the descending aorta

    Energy Technology Data Exchange (ETDEWEB)

    Stoesslein, F.; Porstmann, W.; Schueler, F.; Schoepke, W.

    1982-05-01

    A so far unknown case of a combination of coarctation and a right vertebral artery originating isolatedly from the thoracic aorta is reported, presenting the embryological hypothesis of the development of this anomalous course. The haemodynamic action of the coarctation produces a steal effect so that the vascular segments existing cranially of the stenosis are connected with the poststenotic zone via the vertebral circulation and the anomalous right vertebral artery.

  16. Intrapericardial bronchogenic cyst adherent to ascending aorta in young patient

    Directory of Open Access Journals (Sweden)

    Reddy Atipo-Galloye

    2014-06-01

    Full Text Available Bronchogenic cysts arise from an abnormal budding of the ventral diverticulum of the foregut or the thracheobronchial tree during embryogenesis. An intrapericardial location is an extremely rare finding. Symptoms are related to cardiac structure compression, but in most case they remain asymptomatic. We present a case of intrapericardial bronchogenic cyst in a young patient, resected entirely with repair of right lateral proximal ascending aorta with PTFE graft.

  17. [Resistant arterial hypertension and coarctation of the aorta].

    Science.gov (United States)

    Martínez-Quintana, Efrén; Rossique-Delmas, Pilar; Rodríguez-González, Fayna

    2014-01-01

    Coarctation of the aorta accounts for around 5 percent of all congenital heart defects. Many of these patients develop arterial hypertension, and occasionally resistant arterial hypertension, despite adequate correction. This may lead to potentially fatal complications such as heart failure, aortic dissection, cerebrovascular events, or myocardial infarction. Therefore, a correct diagnosis must be made and an appropriate treatment started to reduce arterial hypertension, arteriosclerotic vascular disease, as well as the increased risk of cardiovascular morbidity and mortality.

  18. Emergent treatment of patients with traumatic aorta ruptures

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-ying; DI Dong-mei; JIANG Nan-qing; QIAN Yong-xiang; ZHAN Xiang-hong

    2007-01-01

    Objective: To discuss our experience on the diagnosis and treatment of thoracic aorta rupture (TAR) that is one of the main common causes of death in the victims under blunt chest trauma.Methods: Between July 2001 and March 2006, 9 patients (6 men and 3 women, aged from 20 to 54 years) suffering from acute traumatic aorta rupture after motor vehicle accidents received emergent surgical treatments in our hospital. Based on our experience in the rescue of the first TAR patient we introduced a practical procedure on the diagnosis and treatment of TAR in our department. All the other patients generally followed this procedure. Eight patients received contrast material enhanced helical computerized tomography scan before the operation. The leakage of constrast medium from the aorta isthmus was found, and diagnosis of TAR was confirmed. Seven patients underwent immediate operation within 14 hours after accidents. One patient was treated on the 5th day of the accident because of delayed diagnosis of aortic rupture. All patients received general anesthesia with double lumen endotracheal tube and normothermic femoro-femoral partial cardiopulmonary bypass, with beating heart and aortic clamping. One patient received simple repair, and others received partial replacement of thoracic aorta with artificial vascular graft.Results: Seven TAR patients were successfully salvaged. Three patients combined brain injury as well as extremitiy hemiplegia before operation. After treatments one was fully and two partially recovered without paraplegia. Conclusions: Proper practical protocol is emphasized for the surgical repair of TAR because it will reduce the mortality of severe blunt chest injury.

  19. CT and MR imaging of the thoracic aorta

    Directory of Open Access Journals (Sweden)

    Di Cesare Ernesto

    2016-01-01

    Full Text Available At present time, both CT and MRI are valuable techniques in the study of the thoracic aorta. Nowadays, CT represents the most widely employed technique for the study of the thoracic aorta. The new generation CTs show sensitivities up to 100% and specificities of 98-99%. Sixteen and wider row detectors provide isotropic pixels, mandatory for the ineludible longitudinal reconstruction. The main limits are related to the X-ray dose expoure and the use of iodinated contrast media. MRI has great potential in the study of the thoracic aorta. Nevertheless, if compared to CT, acquisition times remain longer and movement artifact susceptibility higher. The main MRI disadvantages are claustrophobia, presence of ferromagnetic implants, pacemakers, longer acquisition times with respect to CT, inability to use contrast media in cases of renal insufficiency, lower spatial resolution and less availability than CT. CT is preferred in the acute aortic disease. Nevertheless, since it requires iodinated contrast media and X-ray exposure, it may be adequately replaced by MRI in the follow up of aortic diseases. The main limitation of MRI, however, is related to the scarce visibility of stents and calcifications.

  20. Elastic characteristics of aorta in patients with epilepsy

    Directory of Open Access Journals (Sweden)

    Yılmaz Cingozbay

    2011-02-01

    Full Text Available Aim To investigate elastic characteristics of the aorta in patientswith epilepsy.Methods Seventy five patients with a diagnosis of epilepsy through clinical and EEG findings and age and sex matched, 50 healthy controls were included. Systolic and diastolic blood pressures plus systolic and diastolic diameter of the aortic root was measured. Aortic strain (AS and aortic distensibility (AD and aortic distensibility index (BSI were calculated. Results The average age of the epilepsy group was 23.8.8 ± 8.2 years, and of the control group it was 24.1± 6.2 years (p>0.05. AS and AD were lower in the epileptic group while the aortic stiffness index was higher (10.4± 4.2 vs 16.9±0.2, p: 0.001, for AS; 8.7± 4.0 vs 17.2±0.1, p: 0.001, for AD and 20.1±0.1 vs 3.5±1.2, p: 0.001 for BSI. Conclusion Elastic characteristics of the aorta change in epileptic patients, with a decrease of the distensibility of the aorta and an increaseof the stiffness. After this preliminary study, new controlledstudies are needed.

  1. False aneurysm on distal part of coarctation of the aorta in a parous Turner syndrome patient.

    Science.gov (United States)

    Oi, Keiji; Yoshida, Tetsuya; Takeshita, Masashi; Tsuruta, Goro

    2013-09-01

    False aneurysm associated with untreated coarctation of the aorta (CoA) is an uncommon vascular complication. We present a 41-year-old woman with mosaic Turner syndrome who had CoA complicated with a small false aneurysm on descending aorta just distal to the coarctation. The patient had not been diagnosed with Turner syndrome despite several physical characteristics of the syndrome because she had histories of natural childbirth. The false aneurysm was resected with the coarctation through a thoracotomy and proximal aorta was directly anastomosed to distal aorta. Endovascular therapy has become preferred method in recent years in treatment for coarctation of the aorta. However, careful consideration should be given to the irregularities on the aorta with the coarctation for diagnosis of false aneurysm.

  2. Bongos, champanes y vapores en la navegación fluvial colombiana del siglo XIX

    Directory of Open Access Journals (Sweden)

    Eduardo Posada Carbó

    1989-10-01

    Full Text Available A bordo blanco,  le gritó el patrón del champán a José Joaquín Borda, mientras éste observaba la ancha canoa que lo conduciría a la bodega de Conejo, aquella estación obligada de los vapores que subían por el Magdalena y que, debido a los rápidos del río, no podrían seguir hasta Honda. El viaje de Borda en la Joven Tulia -como se llamaba la embarcación atestada de pacas de tabaco-, en medio de las mercancías y la tradicional algarabía de los bogas, duró seis horas.

  3. FACTIBILIDAD DEL USO DE UN ELISA INDIRECTO PARA LA DETECCIÓN DE Glomus clarum

    Directory of Open Access Journals (Sweden)

    I. de la Providencia

    2004-01-01

    Full Text Available Este trabajo tuvo como objetivo evaluar la factibilidad del uso de un ensayo inmunoenzimático sobre soporte sólido (ELISA, para la detección de esporas de Glomus clarum. Para ello se inmunizaron conejos de la raza Chinchilla con extractos proteicos provenientes de dichas esporas. El suero policlonal obtenido de los animales inmunizados se enfrentó a G. clarum y a las esporas de otras especies de Glomales. Se logró detectar las esporas de G. clarum con el uso del ELISA indirecto a la dilución 1/3 000, sin reacciones cruzadas con las otras especies de Glomales utilizadas en este estudio a esa misma dilución.

  4. Evaluación de harina de botón de oro en dietas para conejos en etapa de crecimiento

    Directory of Open Access Journals (Sweden)

    Victoria E. Quintero P.

    2007-01-01

    Full Text Available En la Universidad Nacional de Colombia sede Palmira (1.000 msnm, 24 °C y precipitación pluvial anual de 1.020 mm se realizó un experimento con 24 conejos destetos Nueva Zelanda blancos (35 días y 900 g de peso promedio, se empleó un modelo estadístico completamente al azar con tres niveles de inclusión en la dieta de harina de botón de oro (T1-15%, T2-30% y T3-45% y un testigo (T4 con concentrado comercial. Las dietas fueron isocalóricas (2.400 kcal e isoproteicas (16%. No se presentaron diferencias significativas (p ‹ 0.05 en consumo de materia seca. Para la ganancia de peso y conversión alimentaria se presentaron diferencias significativas (p ‹ 0.05 con el testigo (27.3 gd-1 y 3.0 respectivamente T4 y T2 emplearon menor número de días para alcanzar 2.000 g (44.3 y 52.1 días respectivamente; T2 presentó la mayor tasa de retorno marginal.

  5. Evaluación geométrica de meniscos frescos y conservados en glicerina al 98 %. Estudio en conejos (Oryctolagus cuniculus

    Directory of Open Access Journals (Sweden)

    Diana Marcela Perez Berrio

    2014-07-01

    Full Text Available Los aloimplantes de meniscos se han utilizado como fuente de tejido a la hora de sustituirlos por roturas o daños irreparables. Para determinar posibles cambios o no por conservación se planteó como objetivo evaluar geométricamente meniscos frescos y conservados en glicerina al 98 %. Se utilizaron 15 meniscos mediales, provenientes de ocho conejos de raza nueva zelanda albina, separados en tres grupos: cinco meniscos frescos (GI, cinco meniscos conservados por ocho meses en glicerina al 98 % (GII y cinco meniscos conservados por ocho meses en glicerina al 98 % y rehidratados en solución salina 0,9 %, por 24 horas (GIII. Todos los meniscos se midieron con pie de rey en siete puntos de su estructura geométrica. El estudio estableció que no hubo diferencias estadísticas en las medidas estudiadas de GII y GIII con relación a GI y al comparar las medidas de GIII con GII tampoco las hubo, por lo que se podría considerar innecesaria a la rehidratación por 24 horas en solución salina antibiótica.

  6. Acceptability of virtual unenhanced CT of the aorta as a replacement for the conventional unenhanced phase

    Energy Technology Data Exchange (ETDEWEB)

    Shaida, N., E-mail: nadeem.shaida@addenbrookes.nhs.uk [Department of Radiology, Addenbrooke' s Hospital, Cambridge (United Kingdom); Bowden, D.J.; Barrett, T.; Godfrey, E.M.; Taylor, A.; Winterbottom, A.P.; See, T.C. [Department of Radiology, Addenbrooke' s Hospital, Cambridge (United Kingdom); Lomas, D.J. [Department of Radiology, University of Cambridge, Addenbrooke' s Hospital, Cambridge (United Kingdom); Shaw, A.S. [Department of Radiology, Addenbrooke' s Hospital, Cambridge (United Kingdom)

    2012-05-15

    Aim: To evaluate whether virtual unenhanced (VU) computed tomography (CT) images generated of the aorta were of sufficient quality to replace the conventional unenhanced (CU) images. Materials and methods: Forty-nine patients undergoing examination of the thoracic or abdominal aorta were examined using a dual-energy protocol. VU images were generated from the arterial phase images and compared to the CU images. Objective analysis was performed by drawing paired regions of interest (ROIs) within the thoracic and abdominal aorta and measuring the radiodensity in Hounsfield units attenuation within the ROIs. Subjective analysis was performed by two experienced readers evaluating the VU images in terms of noise, quality, calcium loss, and overall acceptability. Results: The attenuation was significantly higher in the VU images compared to the CU images within the thoracic aorta (p < 0.01) but not within the abdominal aorta (p = 0.15). Overall the VU images of the abdominal aorta were deemed acceptable as replacements for the CU images in 93% of cases. For the thoracic aorta, the VU images were deemed acceptable in only 12% of cases, primarily due to pulsation artefact. Conclusion: VU images of the abdominal aorta are acceptable as replacements for the CU images in the vast majority of cases; however, they are not suitable as replacements for the CU images of the thoracic aorta.

  7. Cannulation in the diseased aorta: a safe approach using the Seldinger technique.

    Science.gov (United States)

    Khoynezhad, Ali; Plestis, Konstadinos A

    2006-01-01

    The Seldinger technique is a method of femoral cannulation that has been used to establish cardiopulmonary bypass. Reports of cannulation of the ascending aorta for antegrade perfusion using the Seldinger method are anecdotal. To the best of our knowledge, the approach described herein for direct cannulation of the ascending aorta with use of the Seldinger technique for antegrade perfusion has not been previously described in the English-language medical literature. This method is helpful when the surgeon is treating a patient who has a calcified ascending aorta, complicated aortic dissection, calcified femoral vessels, or a diseased thoracoabdominal aorta. In such cases, retrograde perfusion has been associated with severe complications as a result of atheromatous embolization from the descending thoracic aorta. Herein, we describe our approach to cannulation for cardiopulmonary bypass, which entails insertion of an aortic cannula into the ascending aorta by means of the Seldinger technique. A soft-tip guidewire is inserted through an arterial entry catheter that has been used to puncture a hole in the wall of the vessel. Then the aortic cannula is introduced into the vessel, sliding along the guidewire. Guided by transesophageal echocardiography, the tip of the cannula is positioned carefully and is then advanced into the descending aorta. This positioning of the cannula decreases the chance of arterial embolization, thereby improving cerebral protection. If cannulation of the ascending aorta is not feasible, the transverse aortic arch or proximal descending aorta can be used.

  8. Os ramos colaterais da aorta abdominal em jaguatirica (Leopardus pardalis

    Directory of Open Access Journals (Sweden)

    Luane L. Pinheiro

    2014-05-01

    Full Text Available A jaguatirica (Leopardus pardalis é uma das espécies de felino silvestre que pouco foi investigada quanto a sua morfologia. Assim, o estudo objetivou detalhar a origem e distribuição dos ramos colaterais da aorta abdominal deste animal. Avaliou-se dois exemplares, sendo um macho e uma fêmea, jovens, provenientes de Paragominas-PA, doados ao Laboratório de Pesquisa Morfológica Animal (LaPMA da Universidade Federal Rural da Amazônia (UFRA. O sistema arterial foi preenchido com látex pigmentado de vermelho e os cadáveres foram preservados com solução de formaldeído tamponado a 10%. A aorta abdominal do L. pardalis teve origem entre T12 e L1, sendo a artéria celíaca o primeiro ramo visceral no sentido crânio-caudal, resultando nas artérias hepática, gástrica esquerda e esplênica. A artéria mesentérica cranial surgiu como segundo ramo da aorta abdominal, originando as artérias jejunais. Na sequência localizamos artéria pancreáticoduodenal caudal, artérias ileais, artérias ileocólicas, artérias renais direita e esquerda, artérias adrenais direita e esquerda e artérias ováricas ou testiculares direita e esquerda. Parietalmente, a aorta abdominal originou em média seis ramos lombares, bem como a artéria frenicoabdominal, as artérias circunflexas ilíacas profundas e artérias ilíacas externa e interna. A aorta abdominal gerou ainda a artéria mesentérica caudal, a qual dividiu-se em artérias cólica esquerda e retal cranial. A artéria cólica esquerda seguiu cranialmente paralela ao cólon descendente irrigando-o, originando em média 18 ramos, e anastomosando-se com a artéria cólica média. A artéria retal cranial seguiu em direção caudal distribuindo oito ramos à porção final do cólon descendente e ao reto, e uniu-se com a artéria retal média. Por fim, a aorta abdominal emitiu como ramo terminal a artéria sacral mediana. A vascularização arterial abdominal desta espécie é bastante semelhante ao

  9. Zooarqueología y tafonomía en un yacimiento solutrense del sureste de la Península Ibérica: La Cueva de Ambrosio

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    José Yravedra Sainz de los Terreros

    2007-01-01

    Full Text Available Uno de los yacimientos solutrenses más emblemáticos del sureste de la Península Ibérica es la Cueva de Ambrosio, sin embargo hasta hace poco el estudio de sus faunas sólo se había hecho de manera muy parcial. La zooarqueología y la tafonomía que presentamos en este trabajo, nos muestra que ciervos, caballos, cabras y conejos fueron explotados predominantemente por el ser humano, pero además, otros análisis han permitido distinguir qué estrategias espacio temporales siguieron los cazadores de Cueva Ambrosio.

  10. ¿Es necesaria la reconstrucción de la conjuntiva?: Trabajo experimental en conejos albinos para evaluar la neogénesis de la conjuntiva Is necessary the reconstruction of the conjunctiva?: Experimental research in albino rabbits to demostrate conjunctiva regeneration

    Directory of Open Access Journals (Sweden)

    E. A. Moretti

    2007-03-01

    Full Text Available En los defectos de espesor total del párpado inferior de gran magnitud, siempre ha sido regla de oro la reconstrucción de la lamela posterior (tarso y conjuntiva palpebral. Esto es debido a que el tono del músculo orbicularis oculi no alcanza a mantener el soporte necesario para resistir la acción de la gravedad y/o contractura cicatricial. Además la ausencia de conjuntiva provocaría lesiones sobre la córnea ocular. Es por ello que el empleo de injertos compuestos condromucosos ha sido insustituible. El presente trabajo de investigación fue realizado en 20 conejos albinos con el objeto de evaluar la posibilidad de emplear cartílago auricular para la reconstrucción del tarso sin colocación de mucosa a modo de conjuntiva sobre dicho cartílago. Los resultados obtenidos permiten confirmar por diferentes tinciones histológicas sobre biopsias comparadas con zonas testigo, el crecimiento de tejido conjuntival sobre el pericondrio sin provocar lesiones oculares (neogénesis de conjuntiva. Los hallazgos encontrados provocan importantes y sustanciales cambios en la cirugía reconstructiva del párpado inferior debido a que de esta manera, no sería necesaria la reconstrucción de la conjuntiva palpebral, siendo útil exclusivamente la colocación de cartílago.In a full-thickness defect of a lower eyelid, as a general rule, is mandatory to reconstruct the tarsal plate and the conjunctiva. The reason is that the orbicularis oculi muscle cannot support the effects of gravity and/or cicatricial contracture. The abscense of conjunctiva provokes corneal lesions. Therefore, a chondromucosal graft is obligatory. This research has been performed in 20 albino rabbits to evaluate the possibility of tarsal plate reconstruction with conchal cartilage graft without mucosa. The results of the research have demonstrated, by different histological biopsies, that the raw surface of the perichondrium is epithelized with a new conjunctiva (neoconjunctiva. These

  11. Treatment of traumatic rupture of the thoracic aorta

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    Davidović Lazar

    2008-01-01

    Full Text Available INTRODUCTION Interest for traumatic thoracic aorta rupture stems from the fact that its number continually increases, and it can be rapidly lethal. OBJECTIVE The aim of this study is to present early and long term results as well as experiences of our team in surgical treatment of traumatic thoracic aorta rupture. METHOD Our retrospective study includes 12 patients with traumatic thoracic aorta rupture treated between 1985 and 2007. There were 10 male and two female patients of average age 30.75 years (18-74. RESULTS In six cases, primary diagnosis was established during the first seven days days after trauma, while in 6 more than one month later. In 11 cases, classical open surgical procedure was performed, while endovascular treatment was used in one patient. Three (25% patients died, while two (16.6% had paraplegia. Nine patients (75% were treated without complications, and are in good condition after a mean follow-up period of 9.7 years (from one month to 22 years. CONCLUSION Surgical treatment requires spinal cord protection to prevent paraplegia, using cardiopulmonary by-pass (three of our cases or external heparin-bonded shunts (five of our cases. Cardiopulmonary by-pass is followed with lower incidence of paraplegia, however it is not such a good solution for patients with polytrauma because of hemorrhage. The endovascular repair is a safe and feasible procedure in the acute phase, especially because of traumatic shock and polytrauma which contributes to higher mortality rate after open surgery. On the other hand, in chronic postrauamatic aortic rupture, open surgical treatment is connected with a lower mortality rate and good long-term results. There have been no published data about long-term results of endovascular treatment in the chronic phase.

  12. The AORTA Architecture: Integrating Organizational Reasoning in Jason

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Dignum, Virginia; Villadsen, Jørgen

    2014-01-01

    the expected behavior of the agents. Agents need to be able to reason about the regulations, so that they can act within the expected boundaries and work towards the objectives of the organization. In this paper, we describe the AORTA (Adding Organizational Reasoning to Agents) architecture for making agents...... organization-aware. It is designed such that it provides organizational reasoning capabilities to agents implemented in existing agent programming languages without being tied to a specific organizational model. We show how it can be integrated in the Jason agent programming language, and discuss how...

  13. Pseudo-dissection of ascending aorta in inferior myocardial infarction.

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    Grahame K. Goode

    2011-06-01

    Full Text Available Acute aortic dissection is a cardiac emergency which can present as inferior myocardial infarction. It has high morbidity and mortality requiring prompt diagnosis and treatment. Rapid advances in noninvasive imaging modalities have facilitated the early diagnosis of this condition and in ruling out this potentially catastrophic illness. We report an interesting case of a 57 year- old -man who presented with inferior myocardial infarction requiring thrombolysis and temporary pacing wire for complete heart block. An echocardiogram was highly suspicious of aortic dissection. CT scan confirmed that the malposition of the temporary pacing wire through the aorta mimicked aortic dissection.

  14. Coarctation of the aorta:Management from infancy to adulthood

    Institute of Scientific and Technical Information of China (English)

    Rachel; D; Torok; Michael; J; Campbell; Gregory; A; Fleming; Kevin; D; Hill

    2015-01-01

    Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical symptoms, in isolation, or in association with other cardiac defects. The first surgical repair of aortic coarctation was described in 1944, and since that time, several other surgical techniques have been developed and modified. Additionally, transcatheter balloon angioplasty and endovascular stent placement offer less invasive approaches for the treatment of coarctation of the aorta for some patients. While overall morbidity and mortality rates are low for patients undergoing intervention for coarctation, both surgical and transcatheter interventions are not free from adverse outcomes. Therefore, patients must be followed closely over their lifetime for complications such as recoarctation, aortic aneurysm, persistent hypertension, and changes in any associated cardiac defects. Considerable effort has been expended investigating the utility and outcomes of various treatment approaches for aortic coarctation, which are heavily influenced by a patient’s anatomy, size, age, and clinical course. Here we review indications for intervention, describe and compare surgical and transcatheter techniques for management of coarctation, and explore the associated outcomes in both children and adults.

  15. Ebstein's anomaly with coarctation of the aorta. An unusual association

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    Munir Ebaid

    1999-08-01

    Full Text Available Ebstein's anomaly with coarctation of the aorta is an extremely unusual condition. In this report, the clinical and surgical features of 3 male patients, aged 7 months, 4 years and 14 years, are discussed. All patients were in situs solitus. The first 2 patients had atrioventricular and ventriculoarterial discordance and progressed to heart failure in the neonatal period. The third had atrioventricular and ventriculoarterial concordance, as well as Wolf-Parkinson-White syndrome, with frequent episodes of paroxysmal tachycardia. The 3 patients underwent surgery for correction of the coarctation of the aorta. The patient with atrioventricular and ventriculoarterial concordance underwent tricuspid valvuloplasty using a DeVega-like technique. In addition, ablation of 2 anomalous pathways (Kent bundle, which were detected by the electrophysiologic study, was also subsequently performed. The 3 patients showed a good postoperative outcome for 2 years, although, in those with discordance, the surgical procedure did not influence the dysplasia of the tricuspid valve, because this valve showed light to moderate dysfunction.

  16. Branches of the abdominal aorta in Aotus azarae infulatus

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    Bianca Mendonça Faria

    2016-05-01

    Full Text Available The genus Aotus is found in South America and is known for its nocturnal habit. The morphology of the genus is poorly understood even though it is used in biomedical research. The objective of this study was to identify the collateral branches of the abdominal aorta of two females and one male Aotus azarae infulatus (commonly known as the night monkey. The vessels were observed and stained with Neoprene latex and radiopaque contrast. The animals were fixed in an aqueous solution of 10% formaldehyde via intramuscular and intracavitary routes, dissected and radiographed. It was observed that the celiac artery was divided into three subjacent branches, the gastric, hepatic and splenic arteries. The left and right renal arteries originated from a common trunk in two animals (animals 1 and 2, while the adrenal artery in one of the animals was derived from the celiac trunk and renal artery (animal 2. In one animal the mesenteric artery flow gave rise to individual cranial rectal, sigmoid and left colic arteries (animal 3. In the three animals the abdominal aorta bifurcated in the final portion of the abdomen, with the external and internal iliac artery on each side, and then the median sacral artery. These anatomical variations need to be identified and reported because these animals are frequently used in clinical and surgical, veterinary practices.

  17. Elastin aging and lipid oxidation products in human aorta

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    Kamelija Zarkovic

    2015-04-01

    Full Text Available Vascular aging is associated with structural and functional modifications of the arteries, and by an increase in arterial wall thickening in the intima and the media, mainly resulting from structural modifications of the extracellular matrix (ECM components. Among the factors known to accumulate with aging, advanced lipid peroxidation end products (ALEs are a hallmark of oxidative stress-associated diseases such as atherosclerosis. Aldehydes generated from the peroxidation of polyunsaturated fatty acids (PUFA, (4-hydroxynonenal, malondialdehyde, acrolein, form adducts on cellular proteins, leading to a progressive protein dysfunction with consequences in the pathophysiology of vascular aging. The contribution of these aldehydes to ECM modification is not known. This study was carried out to investigate whether aldehyde-adducts are detected in the intima and media in human aorta, whether their level is increased in vascular aging, and whether elastin fibers are a target of aldehyde-adduct formation. Immunohistological and confocal immunofluorescence studies indicate that 4-HNE-histidine-adducts accumulate in an age-related manner in the intima, media and adventitia layers of human aortas, and are mainly expressed in smooth muscle cells. In contrast, even if the structure of elastin fiber is strongly altered in the aged vessels, our results show that elastin is not or very poorly modified by 4-HNE. These data indicate a complex role for lipid peroxidation and in particular for 4-HNE in elastin homeostasis, in the vascular wall remodeling during aging and atherosclerosis development.

  18. Coarctation of the aorta: Management from infancy to adulthood.

    Science.gov (United States)

    Torok, Rachel D; Campbell, Michael J; Fleming, Gregory A; Hill, Kevin D

    2015-11-26

    Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical symptoms, in isolation, or in association with other cardiac defects. The first surgical repair of aortic coarctation was described in 1944, and since that time, several other surgical techniques have been developed and modified. Additionally, transcatheter balloon angioplasty and endovascular stent placement offer less invasive approaches for the treatment of coarctation of the aorta for some patients. While overall morbidity and mortality rates are low for patients undergoing intervention for coarctation, both surgical and transcatheter interventions are not free from adverse outcomes. Therefore, patients must be followed closely over their lifetime for complications such as recoarctation, aortic aneurysm, persistent hypertension, and changes in any associated cardiac defects. Considerable effort has been expended investigating the utility and outcomes of various treatment approaches for aortic coarctation, which are heavily influenced by a patient's anatomy, size, age, and clinical course. Here we review indications for intervention, describe and compare surgical and transcatheter techniques for management of coarctation, and explore the associated outcomes in both children and adults.

  19. Intima-media thickness of the descending aorta in patients with bicuspid aortic valve

    Directory of Open Access Journals (Sweden)

    Johan Petrini

    2016-06-01

    Conclusions: Intima-media thickness of the descending aorta is not affected by aortic valve morphology (BAV/TAV; age is the main determinant of AoIMT. Genetic markers (SNPs known to influence IMT in the carotid artery seem to correlate to IMT in the descending aorta only in patients with TAV.

  20. Extraanatomic reconstruction for isolated thoracic aorta coarctation in an adult patient.

    Science.gov (United States)

    Lee, Seung Hyun; Kim, Jae Bum; Park, Nam Hee; Keum, Dong Yoon; Choi, Sea Young

    2012-10-01

    A 42-year-old male patient with no medical history except hypertension presented with intermittent chest pain radiating to the left shoulder. From coronary computed tomography, a coarctation of proximal descending thoracic aorta was found demonstrating near aortic occlusion. From various available surgical options for this condition, we chose extraanatomic bypass from the left subclavian artery to the descending aorta.

  1. The Inhibitory Effect of Astilbin on the Arteriosclerosis of Murine Thoracic Aorta Transplant

    Institute of Scientific and Technical Information of China (English)

    Jinping ZHAO; Ping LI; Yunfeng ZHANG; Xianguo WANG; Qilin AO; Sihai GAO

    2009-01-01

    The inhibitory effect of astilbin on transplant arteriosclerosis in murine model of thoracic aorta transplantation was examined.Model of rat thoracic aorta transplantation was established.Ninety rats were divided into three groups.In isograft group,the thoracic aorta of Brown Norway (BN) rat was anastomosed with the abdominal aorta of another BN rat.In allograft group,the thoracic aorta of BN rat was anastomosed with the abdominal aorta of Lewis rat.In astilbin group,the rats receiving allo-transplantation were given astiibin 5 mg/kg per day for a time of 28 days.The donor thoracic aorta and the recipient abdominal aorta were anastomosed by means of a polyethylene cannula (inner diameter:1.5 mm,length:3 mm length).The grafts were histologically examined for structural changes.The areas of arterial lumen and endatrium were calculated.Our results showed that,in the allograft group,28 days after aliografting,conspicuous proliferation of smooth muscles and infiltration with a great number of inflammatory cells were found in the tunica intima and tunica media.Astilbin significantly inhibited the proliferation of smooth muscles and ameliorated the infiltration of inflammatory cells thereyby prevent against the development of transplant arteriosclerosis.It is concluded that asltilbin can effectively prevent the development of arteriosclerosis in allotrausplant by inhibiting the proliferation of smooth muscles and inhibit the proliferation of smooth muscles in tunica of intima and media and reducing infiltration of the inflammatory cells.

  2. Pressure-volume characteristics of aortas of harbor and Weddell seals.

    Science.gov (United States)

    Rhode, E A; Elsner, R; Peterson, T M; Campbell, K B; Spangler, W

    1986-07-01

    The mechanical properties of the radially enlarged proximal segment of the aorta of diving marine mammals was studied on 15 excised aortas of harbor seals and five aortas of Weddell seals. This was done by recording static pressure-volume relationships for the whole thoracic aorta, the aortic bulb, and the descending thoracic aorta and passive length-tension measurements of aortic strips. Aortic bulb volume distensibility was found to be much greater than that of the descending thoracic aorta or of an equivalent aortic segment of terrestrial mammals. The consequences were that the total potential energy and volume that may be stored within the aortic bulb is very large, with a capacity for storage of the stroke work of more than two normal heart beats and a volume of more than three times normal stroke volume. The aortic bulb has an average radius and wall thickness twice that of the descending aorta, but at any level of distension the wall stress (g/cm2) is the same throughout. The static mechanical properties of aortic strips from the bulb and descending thoracic aortas were not markedly different, so that the differences in the pressure-volume relationships are explained by differences in geometry of the two sections. The expanded aortic bulb functions through energy and volume storage actions and through uncoupling actions to maintain arterial pressures and stroke volume at near predive levels during a dive.

  3. Rotura de aneurisma de aorta abdominal: su importancia como diagnostico diferencial en abdomen agudo

    Directory of Open Access Journals (Sweden)

    Vanessa Orellana-Villazón

    2008-01-01

    Full Text Available El aneurisma aórtico abdominal (AAA roto es una forma de presentación poco frecuente de los AAA. Presentamos un caso de rotura de aneurisma de aorta abdominal (AAAr de un paciente varón de 76 años de edad que ingresa al servicio de emergencias del Hospital Elizabeth Setón por presentar dolor abdominal punzante en región lumbar derecha de inicio súbito e intensidad creciente, llegando a perder el conocimiento. La impresión diagnóstica inicial incluye cólico ureteral e hipertensión arterial; sin embargo después realizar una ecografía abdominal y posteriormente una tomografía abdominal se concluye con el diagnostico de AAAr. El paciente es sometido a cirugía de emergencia, y después de permanecer tres días en terapia intensiva y tres días en sala, es dado de alta. Consideramos importante informar este caso clínico por la frecuencia con que se le confunde con patologías renales o abdomen agudo, pese a la sintomatología característica que presenta, que en muchos casos lleva a un diagnostico retrasado y posteriormente a la muerte.

  4. ROTURA DE ANEURISMA DE AORTA ABDOMINAL: SU IMPORTANCIA COMO DIAGNOSTICO DIFERENCIAL EN ABDOMEN AGUDO

    Directory of Open Access Journals (Sweden)

    Vanessa Orellana-Villazón

    2012-02-01

    Full Text Available El aneurisma aórtico abdominal (AAA roto es una forma de presentación poco frecuente de los AAA. Presentamos un caso de rotura de aneurisma de aorta abdominal (AAAr de un paciente varón de 76 años de edad que ingresa al servicio de emergencias del Hospital Elizabeth Setón por presentar dolor abdominal punzante en región lumbar derecha de inicio súbito e intensidad creciente, llegando a perder el conocimiento. La impresión diagnóstica inicial incluye cólico ureteral e hipertensión arterial; sin embargo después realizar una ecografía abdominal y posteriormente una tomografía abdominal se concluye con el diagnostico de AAAr. El paciente es sometido a cirugía de emergencia, y después de permanecer tres días en terapia intensiva y tres días en sala, es dado de alta. Consideramos importante informar este caso clínico por la frecuencia con que se le confunde con patologías renales o abdomen agudo, pese a la sintomatología característica que presenta, que en muchos casos lleva a un diagnostico retrasado y posteriormente a la muerte.

  5. Protective effect of zingerone on increased vascular contractility in diabetic rat aorta.

    Science.gov (United States)

    Ghareib, Salah A; El-Bassossy, Hany M; Elberry, Ahmed A; Azhar, Ahmad; Watson, Malcolm L; Banjar, Zainy M; Alahdal, Abdulrahman M

    2016-06-05

    The aim of the present study was to investigate the effect and possible mechanism of action of zingerone, the main constituent of ginger, on vascular reactivity in isolated aorta from diabetic rats. The results show that incubation of aortae with zingerone alleviates the exaggerated vasoconstriction of diabetic aortae to phenylephrine, as well as the impaired relaxatory response to acetylcholine in a concentration-dependent manner. Furthermore, Zingerone directly relax phenylephrine-precontracted aortae. The vasorelaxatory response is significantly attenuated by the nitric oxide synthase inhibitor Nω-nitro-l-arginine methyl ester hydrochloride and the guanylate cyclase inhibitor methylene blue but no effect of either the potassium channels blocker tetraethylammonium chloride, or the cyclooxygenase inhibitor indomethacin was observed. Zingerone had no effect on advanced glycation end product formation as well. In conclusion, zingerone ameliorates enhanced vascular contraction in diabetic aortae which may be mediated by its vasodilator effect through NO- and guanylate cyclase stimulation.

  6. Chest radiography in acute traumatic rupture of the thoracic aorta

    Energy Technology Data Exchange (ETDEWEB)

    Heystraten, F.M.; Rosenbusch, G.; Kingma, L.M.; Lacquet, L.K.; Boo, T. de; Lemmens, W.A.

    Of 123 patients who had suffered blunt trauma to the chest traumatic aortic rupture was eventually confirmed in 61 and absent in 62 patients. The chest radiographs of these patients were examined for 15 signs reported in the literature as being associated with traumatic aortic rupture. Although many individual signs were significantly more frequent in the aortic rupture group they were not useful in differentiating between patients with and those without rupture of the aorta. By using discriminant analysis combining 2 or 3 signs, patients were classified as having aortic rupture or not. The best discrimination between the two groups was obtained using the combined signs of a widened paratracheal stripe, and opacified pulmonary window, a widened right paraspinal interface and a displaced nasogastric tube.

  7. Ayahuasca Alters Structural Parameters of the Rat Aorta.

    Science.gov (United States)

    Pitol, Dimitrius L; Siéssere, Selma; Dos Santos, Rafael G; Rosa, Maria L N M; Hallak, Jaime E C; Scalize, Priscilla H; Pereira, Bruno F; Iyomasa, Melina M; Semprini, Marisa; Riba, Jordi; Regalo, Simone C H

    2015-07-01

    Ayahuasca is a hallucinogenic brew traditionally used by Northwestern Amazonian indigenous groups for therapeutic purposes. It is prepared by the decoction of Banisteriopsis caapi with the leaves of Psychotria viridis. Banisteriopsis caapi contains β-carbolines that are inhibitors of monoamine oxidase and P. viris is rich in dimethyltryptamine, a 5-HT(1A/2A/2C) agonist. Acute ayahuasca administration produces moderate cardiovascular effects in healthy volunteers, but information regarding long-term use is lacking. This study investigated the effects of ayahuasca (2-4 mL/kg) in the rat aorta after acute and chronic (14 days) administration. Ayahuasca caused flattening and stretching of vascular smooth muscle cells and changes in the arrangement and distribution of collagen and elastic fibers. Chronic treatment with the higher dose significantly increased media thickness and the ratio of media thickness to lumen diameter. More research is needed on the cardiovascular function of long-term ayahuasca consumers.

  8. [Aorta-associated complications after prosthetic repair of the aortic valve].

    Science.gov (United States)

    Bazylev, V V; Vachev, S A; Karnakhin, V A; Bartosh, F L; Rosseĭkin, E V

    2015-01-01

    The authors analyzed dependence between the presence of preoperative predictors of aorta-associated complications and risk for the development of these complications in the remote period after prosthetic repair of the aortic valve. The study included a total of 231 patients subjected to aortic valve prosthetic repair with no additional intervention on the root and ascending portion of the aorta. The follow up duration varied from 12 to 62 months. As predictors of the development of aorta-associated complications we examined such factors as the bicuspid structure of the aortic valve, dilatation of the aortic ascending portion relative to the upper border of the individually calculated norm, disordered configuration of the complex "aortic root - ascending portion of the aorta", resistant arterial hypertension, diabetes mellitus. Depending on the number of predictors for the development of aorta-associated complications the patients were subdivided into 2 groups: Group One consisting of 105 patients with two and more predictors of the development of aorta-associated complications, and Group Two comprising 126 patients with not more than one predictor of the development of aorta-associated complications. It was determined that in the first group of patients the total number of aorta-associated complications in the remote period after prosthetic repair of the aortic valve amounted to 25.7% (27 of 105 patients). The total number of aorta-associated complications in the second group amounted to 1.6% (2 of 126 patients). All detected aorta-associated complications were divided into "critical" and "noncritical". The critical complications were those the detection of which required performing a second operation in the patient: formation of an ascending aortic aneurysm and type A aortic dissection. To the "noncritical" aorta-associated complications belonged dilatation of the ascending portion of the aorta progressing at a rate of 2 mm/year. Resulting from the performed study

  9. Self-expandable nitinol stent placement in homocysteinemic porcine aorta

    Directory of Open Access Journals (Sweden)

    Luís Henrique Gil França

    2008-01-01

    Full Text Available PURPOSE: To compare aortic intimal thickening of normal and hyperhomocysteinemic pigs (induced with a methionine-rich diet following placement of a self-expanding nitinol stent. METHODS: Eighteen Macau pigs were used. They were older than eight weeks in age and had an average weight of 30 kg. Pigs were randomly divided into two groups. The first, Group C (control, was fed a regular diet, and the second group, Group M, was fed a methionine-rich diet for 30 days to induce hyperhomocysteinemia. The self-expandable nitinol stents were 25mm in length and 8 mm in diameter after expansion. Blood samples were collected to measure total cholesterol, triglycerides, HDL and homocysteine concentrations. All animals were subjected to angiography. Thirty days after the procedure, the animals were sacrificed, and the abdominal aorta was removed for histological and digital morphometry analysis. RESULTS: Under microscopic evaluation, the intima was significantly thicker in Group C than in Group M. When groups were compared by digital morphometric analysis, intimal thickening of the vessel wall was higher in Group C than in Group M. There was no significant change in total cholesterol, triglycerides or HDL concentrations in either group. In group C the levels of plasma homocysteine ranged from 14,40 to 16,73µmol/l; in Group M, plasma homocysteine levels ranged from 17.47 to 59.80 µmol/l after 30 days of a methionine-rich diet. CONCLUSION: Compared to normal pigs, less intimal hyperplasia was observed in the abdominal aortas of hyperhomocysteinemic pigs thirty days after the insertion of a self-expandable nitinol stent.

  10. Basal lamina structural alterations in human asymmetric aneurismatic aorta

    Directory of Open Access Journals (Sweden)

    M Cotrufo

    2009-06-01

    Full Text Available Basal lamina (BL is a crucial mechanical and functional component of blood vessels, constituting a sensor of extracellular microenvironment for endothelial cells and pericytes. Recently, an abnormality in the process of matrix microfibrillar component remodeling has been advocated as a mechanism involved in the development of aortic dilation.We focused our attention on BL composition and organization and studied some of the main components of the Extracellular Matrix such as Tenascin, Laminins, Fibronectin, type I, III and IV Collagens.We used surgical fragments from 27 patients, submitted to operation because of aortic root aneurysm and 5 normal aortic wall specimens from heart donors without any evidence for aneurysmal or atherosclerotic diseases of the aorta. Two samples of aortic wall were harvested from each patient, proximal to the sinotubular junction at the aortic convexity and concavity. Each specimen was processed both for immunohistochemical examination and molecular biology study.We compared the convexity of each aortic sample with the concavity of the same vessel, and both of them with the control samples. The synthesis of mRNA and the levels of each protein were assessed, respectively, by RTPCR and Western Blot analysis. Immunohistochemistry elucidated the organization of BL, whose composition was revealed by molecular biology. All pathological samples showed a wall thinner than normal ones. Basal lamina of the aortic wall evidentiated important changes in the tridimensional arrangement of its major components which lost their regular arrangement in pathological specimens. Collagen I, Laminin a2 chain and Fibronectin amounts decreased in pathological samples, while type IV Collagen and Tenascin synthesis increased. Consistently with the common macroscopic observation that ascending aorta dilations tend to expand asymmetrically, with prevalent involvement of the vessel convexity and relative sparing of the concavity, Collagen type

  11. Vasorelaxation Effect of Estrone Derivate EA204 in Rabbit Aorta

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    Juan Li

    2016-01-01

    Full Text Available Estrogen and its derivatives exert vascular protective effects, but the underlying mechanisms remain to be studied fully. Objective. To investigate the vasorelaxation effect and related mechanisms of an estrone derivate EA204[3-(2-piperidin-1-yl-ethoxy-estra-1, 3, 5 (10-trien-17-one] on isolated arterial preparation from rabbit thoracic aorta. Methods. Aortic rings from rabbit thoracic aorta were prepared and held in small organ bath filled with Krebs solution; tension change was recorded by a multichannel physiological signal collection and handling system. Results. EA204 (10−5 to 10−3 M induced a concentration-dependent relaxation of aortic rings with endothelium and without endothelium. In denuded arterial preparations, EA204 had a potent relaxing effect on isolated arterial preparations contracted with phenylephrine, norepinephrine, and high-K+ solution or BaCl2. Mechanism study indicates that EA204 relaxes aortic rings by inhibiting Ca2+ channels (both receptor-operating Ca2+ channels and the voltage-dependent Ca2+ channels were involved to decrease extracellular Ca2+ influx and intracellular Ca2+ release. EA204 is different from verapamil, which is a noncompetitive inhibitor of Ca2+ channels. In addition, K+ channels opening may contribute to this vasorelaxation effect. Conclusion. EA204 had a potent endothelium-independent relaxing effect on isolated arterial preparation by inhibiting Ca2+ channels and opening K+ channels. The results suggest that EA204 is a potential compound for treatment of cardiovascular diseases in postmenopausal women.

  12. A system for automatic aorta sections measurements on chest CT

    Science.gov (United States)

    Pfeffer, Yitzchak; Mayer, Arnaldo; Zholkover, Adi; Konen, Eli

    2016-03-01

    A new method is proposed for caliber measurement of the ascending aorta (AA) and descending aorta (DA). A key component of the method is the automatic detection of the carina, as an anatomical landmark around which an axial volume of interest (VOI) can be defined to observe the aortic caliber. For each slice in the VOI, a linear profile line connecting the AA with the DA is found by pattern matching on the underlying intensity profile. Next, the aortic center position is found using Hough transform on the best linear segment candidate. Finally, region growing around the center provides an accurate segmentation and caliber measurement. We evaluated the algorithm on 113 sequential chest CT scans, slice thickness of 0.75 - 3.75mm, 90 with contrast agent injected. The algorithm success rates were computed as the percentage of scans in which the center of the AA was found. Automated measurements of AA caliber were compared with independent measurements of two experienced chest radiologists, comparing the absolute difference between the two radiologists with the absolute difference between the algorithm and each of the radiologists. The measurement stability was demonstrated by computing the STD of the absolute difference between the radiologists, and between the algorithm and the radiologists. Results: Success rates of 93% and 74% were achieved, for contrast injected cases and non-contrast cases, respectively. These results indicate that the algorithm can be robust in large variability of image quality, such as the cases in a realworld clinical setting. The average absolute difference between the algorithm and the radiologists was 1.85mm, lower than the average absolute difference between the radiologists, which was 2.1mm. The STD of the absolute difference between the algorithm and the radiologists was 1.5mm vs 1.6mm between the two radiologists. These results demonstrate the clinical relevance of the algorithm measurements.

  13. Effect of Excessive Potassium Iodide on Rat Aorta Endothelial Cells.

    Science.gov (United States)

    Zhang, Man; Zou, Xiaoyan; Lin, Xinying; Bian, Jianchao; Meng, Huicui; Liu, Dan

    2015-08-01

    The aim of the current study was to investigate the effect of excess iodine on rat aorta endothelial cells and the potential underlying mechanisms. Rat aorta endothelial cells were cultured with iodide ion (3506, 4076, 4647, 5218, 5789, 6360, 6931, and 7512 mg/L) for 48 h. Morphological changes of cells were observed with microscope after Wright-Giemsa staining and acridine orange staining. Cell proliferation was determined with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and cell apoptosis was assessed with flow cytometry. The activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), endothelial nitric oxide synthase (eNOS), induced nitric oxide synthase (iNOS), and concentrations of malondialdehyde (MDA), glutathione (GSH), and protein carbonyl in culture medium were determined with colorimetric method. The expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) was detected by enzyme linked immunosorbent assay. The results showed that excess iodine induced abnormal morphologic changes of cells, inhibited cell proliferation, and increased apoptosis rate. Iodine also reduced the activity of SOD, GSH-Px, and concentrations of GSH and increased the concentrations of MDA and protein carbonyl in a dose-dependent manner. Moreover, excess iodine decreased the activity of eNOS and increased the activity of iNOS and the expression of ICAM-1 and VCAM-1 in culture medium. Our results suggested that excess iodine exposure increased oxidative stress, caused damage of vascular endothelial cells, and altered the expression of adhesion factors and the activity of NOS. These changes may explain the mechanisms underlying excess iodine-induced vascular injury.

  14. Observer variation in vascular CT measurements of the abdominal aorta

    Energy Technology Data Exchange (ETDEWEB)

    England, Andrew [Department of Radiology, South Manchester University Hospitals NHS Trust, Southmoor Road, Manchester M23 9LT (United Kingdom); Department of Medical Imaging and Radiotherapy, University of Liverpool, Johnson Building, Quadrangle, Brownlow Hill, Liverpool L69 3GB (United Kingdom)], E-mail: a.england@liverpool.ac.uk; Butterfield, John S.; Ashleigh, Raymond J. [Department of Radiology, South Manchester University Hospitals NHS Trust, Southmoor Road, Manchester M23 9LT (United Kingdom)

    2008-11-15

    Aim: To assess the inter-observer variation between a radiographer and radiologist when performing CT measurement of the abdominal aorta before endovascular aortic aneurysm repair (EVAR). Methods: A total of 30 consecutive patients who were considered anatomically suitable for EVAR had aortic measurements performed independently by a vascular radioogist and then by a radiographer training vascular and CT imaging. All measurements were performed on a computer workstation using electronic callipers, each patient had 12 anatomical sites evaluated (eight diameters, four vessel lengths). Statistical analysis was performed by the computer package SPSS for Windows 11.01. Results: Of the 30 patients, mean difference in measurements between observers was 2.3 mm {+-} 1.2 mm and 6.0 mm {+-} 6.4 mm for diameter and vessel length measurements, respectively. Two hundred and seven (86%) diameter measurements were {<=}2 mm of each other and 233 (97%) were within {<=}5 mm. Eighty-two (57%) length measurements were within {<=}5 mm, and 100 (83%) within 10 mm or less. Widest variation existed for measurements of common iliac diameter and aortic neck length, where coefficients of variance were 38.2 (95% CI 35.7-41.0) and 40.0 (95% CI 36.2-44.6), respectively. Conclusion: A good level of agreement exists between a trained radiographer and radiologist when comparing vascular CT measurements of the aorta. It is technically feasible for a radiographer to perform these measurements, and improvements in variability may be achieved from a more standardised technique and automated vessel analysis software. Further research is required to establish the overall variability between different observer types when undertaking vascular CT measurements.

  15. A Hemodynamic Predict of an Intra-Aorta Pump Application in Vitro Using Numerical Analysis

    Science.gov (United States)

    Gao, Bin; Chen, Ningning; Chang, Yu

    The Intra-Aorta Pump is a novel LVAD assisting the native heart without percutaneous drive-lines. The Intra-Aorta Pump is emplaced between the radix aortae and the aortic arch to draw-off the blood from the left ventricle to the aorta. To predict the change of pressure drop and blood flow along with the change of pump speed, a nonlinear model has been made based on the structure and speed of the Intra-Aorta Pump. To do this, a nonlinear electric circuit for the Intra-Aorta Pump has been developed. The model includes two speed dependent current sources and flow dependent resistant to simulate the relationship between the pressure drop of the Intra-Aorta Pump and the flow through the pump along with the change of pump speed. The pressure drop and blood flow is derived by solving differential equations with variable coefficients. The parameters of the model are determined by experiment, and the results of the experiment show that these parameters change along with the change of the pump speed distinctness. The accuracy of the model is tested experimentally on a test loop. The comparison of the prediction data derived from the model with the experimental data shows that the error is lest than 15%. The experimental results showed that the model can predict the change of pressure drop and blood flow accurately.

  16. Pérdida de glutatión desde pulmones de conejo en solución de preservación para trasplante: Efectos clínicos y funcionales a corto plazo Loss of glutathione from rabbit lungs in transplant preservation solution

    Directory of Open Access Journals (Sweden)

    MARíA E SOLOVERA R

    2009-01-01

    Full Text Available El daño por isquemia-reperfusión es causa de morbimortalidad en pacientes con trasplante pulmonar. Se desconoce si la solución de preservación habitual del pulmón puede contribuir a la deficiencia de antioxidantes, favoreciendo el estrés oxidativo en el receptor. Objetivo: Evaluar si existe pérdida de glutatión desde pulmones de conejo a la solución de preservación para trasplante. Resultados: Encontramos una disminución en el contenido de glutatión total del pulmón, sin aumento en el contenido de glutatión oxidado. Esto se asoció a la aparición y aumento sostenido de glutatión en la solución de preservación desde los 30 min. Conclusiones: Existe salida de glutatión desde el pulmón no mediada por oxidación de éste y posiblemente favorecida por el gradiente de concentración de glutatión reducido. Esta pérdida deja al tejido vulnerable frente a las condiciones de estrés oxidativo en el receptor.Introduction: Ischemia-reperfusion injury causes morbidity and mortality in lung transplant patients. It is unknown if the usual lung preservation solution favors antioxidant deficiency and thus, increased oxidative stress in the receptor. Objective: To evaluate if there is any loss of glutathione from rabbit lungs to the preservation solution. Results: We found a decrease in lung total glutathione content, without an increase in the oxidized form of this antioxidant. At the same time, we were able to measure increasing levels of glutathione in the preservation solution from 30 min on. Conclusions: There is loss of glutathione from the lung to the preservation solution that is not mediated by glutathione oxidation and likely due to passage of the reduced form along the concentration gradient, rendering the tissue vulnerable to oxidative stress once in the receptor.

  17. Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

    Science.gov (United States)

    Fiz, Francesco; Morbelli, Silvia; Bauckneht, Matteo; Piccardo, Arnoldo; Ferrarazzo, Giulia; Nieri, Alberto; Artom, Nathan; Cabria, Manlio; Marini, Cecilia; Canepa, Marco; Sambuceti, Gianmario

    2016-01-01

    AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride (18F-NaF) uptake, as a marker of ongoing calcification and cardiovascular risk factors. METHODS: Seventy-eight patients (44 females, mean age 63, range 44-83) underwent whole body 18F-NaF positron emission tomography/computed tomography. Cardiovascular risk (CVR) was used to divide these patients in three categories: Low (LR), medium (MR) and high risk (HR). 18F-NaF uptake was measured by manually drawing volumes of interest on the ascending aorta, on the aortic arch, on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool, to obtain target-to-background ratio (TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta. RESULTS: A significant difference in whole thoracic aorta TBR was detected between HR and LR (1.84 ± 0.76 vs 1.07 ± 0.3, P < 0.001), but also between MR and HR-LR (1.4 ± 0.4, P < 0.02 and P < 0.01, respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta (P < 0.01). Myocardial uptake provided an effective CVR classes stratification (P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered (R = 0.67), but it peaked when correlating the descending thoracic segment (R = 0.75), in comparison with the aortic arch and the ascending segment (R = 0.55 and 0.53, respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients’ risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination. PMID:26834946

  18. Neonatal cannibalism in cage-bred wild rabbits (Oryctolagus cuniculus Canibalismo neonatal en conejos silvestres (Oryctolagus cuniculus alojados en jaula

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    P González-Redondo

    2008-01-01

    Full Text Available The aim of this study was to analyse the occurrence of neonatal cannibalism by individually outdoors cage-bred wild rabbit does (Oryctolagus cuniculus. Ninety eight parturitions that were gathered from 19 female cage-born wild rabbits during five consecutive years were monitored for cannibalism incidence. This alteration in maternal behaviour, which was exclusively limited to the peripartum period, had a high incidence (13.3% of parturitions and was significantly associated with inadequate maternal behaviour such as not using straw or hair in nestbuilding or giving birth outside the nest box. In 84.6% of the parturitions with occurrence of cannibalism the does did not introduce hair into the nest boxes, and in 92.3% of the parturitions with cannibalised kits the does did not introduce straw into the nest boxes. Cannibalism was also associated with a large proportion of rabbits that gave birth outside the nest boxes (53.8%. It is discussed that cannibalism practiced by wild rabbit does in captivity is a manifestation of the failure of maternal behaviour, a consequence of the stress they experience in captivity.El objetivo de este estudio fue analizar la práctica de canibalismo neonatal por conejas silvestres (Oryctolagus cuniculus alojadas individualmente en jaulas ubicadas al aire libre. Se controló la incidencia de canibalismo en 98 partos producidos durante cinco años consecutivos por 19 conejas silvestres nacidas en jaula. Esta alteración de la conducta maternal, que estuvo limitada exclusivamente al periparto, tuvo una elevada incidencia (13,3% de los partos y estuvo asociada significativamente con una inadecuada conducta maternal, tal como la no introducción de pelo y paja en los nidales por parte de las conejas o los partos fuera del nidal. En el 84,6% de los partos en los que ocurrió canibalismo las conejas no introdujeron pelo en los nidales, y en el 92,3% de los partos con gazapos canibalizados las conejas no introdujeron paja en

  19. Neurofibromatosis type 1-associated hypertension secondary to coarctation of the thoracic aorta

    Science.gov (United States)

    Mavani, Gaurang; Kesar, Vivek; Devita, Maria V.; Rosenstock, Jordan L.; Michelis, Michael F.; Schwimmer, Joshua A.

    2014-01-01

    Neurofibromatosis type 1 (NF-1), also known as von Recklinghausen's disease, is an autosomal dominant genetic disorder. NF-I vasculopathy has been used to describe various vascular malformations associated with NF-1. Secondary hypertension related to NF-1 vasculopathy has been reported because of renal artery stenosis, coarctation of the abdominal aorta and other vascular lesions; however, coarctation of the thoracic aorta has seldom been reported. We report the first case, to our knowledge, of isolated coarctation of thoracic aorta in a pregnant female with NF-1. Healthcare providers caring for patients with NF-1 should be aware of associated vascular complications. PMID:25852916

  20. Aorta após endoprótese para aneurisma micótico

    OpenAIRE

    Ufuk Alpagut; Murat Ugurlucan; Emin Tireli; Izzet Rozanes; Enver Dayioglu

    2011-01-01

    Endopróteses vasculares são atualmente utilizadas no tratamento de diferentes patologias da aorta. Podem salvar a vida de pacientes com comorbidades e virtualmente inoperáveis quando da utilização de técnicas convencionais. Esse manuscrito relata o caso de um paciente de 40 anos, que havia sido previamente tratado de um aneurisma micótico sacular no arco aórtico e que apresentou ruptura da aorta descendente no seguimento de médio prazo. O tratamento da ruptura da aorta descendente também foi ...

  1. Saccular aneurysm formation of the descending aorta associated with aortic coarctation in an infant.

    Science.gov (United States)

    Ozyuksel, Arda; Canturk, Emir; Dindar, Aygun; Akcevin, Atif

    2014-01-01

    Aneurysm of the descending aorta associated with CoA is an extremely rare congenital abnormality. In this report, we present a 16 months old female patient in whom cardiac catheterization had been performed which had revealed a segment of coarctation and saccular aneurysm in the descending aorta. The patient was operated and a 3x2 centimeters aneurysm which embraces the coarcted segment in descending aorta was resected. In summary, we present a case of saccular aortic aneurysm distal to aortic coarctation in an infant without any history of intervention or vascular inflammatory disease. Our case report seems to be the youngest patient in literature with this pathology.

  2. Huge dissected ascending aorta associated with pseudo aneurysm and aortic coarctation feridoun.

    Science.gov (United States)

    Sabzi, Feridoun; Khosravi, Donya

    2015-07-01

    We report a unique case of chronic dissection of the ascending aorta complicated with huge and thrombotic pseudoaneurysm in a patient with coarctation of descending aorta. Preoperative investigations such as transesophageal echocardiography (TEE) confirmed the diagnosis of dissection. Intraoperative findings included a12 cm eccentric bulge of the right lateral side of dilated the ascending aorta filled with the clot and a circular shaped intimal tear communicating with an extended hematoma and dissection of the media layer. The rarity of the report is an association of the chronic dissection with huge pseudoaneurysm and coarctation. The patient underwent staged repair of an aneurysm and coarctation and had an uneventful postoperative recovery period.

  3. Angiograms of the Abdominal Aorta in a Patient of Middle Aortic Syndrome

    Institute of Scientific and Technical Information of China (English)

    Zhou Yafeng; Yang Xiangjun; Song Jianping; Jiang Tingbo; Li Xun; Hui Jie; Liu Zhihua; Jiang Wenping

    2007-01-01

    A 42-year old woman of middle aortic syndrome presented with severe hypertension for 20 years, whose abdominal aorta angiography revealed long segment and nearly complete occlusion in the mid portion of abdominal aorta, and extensively enlarged collateral vascular supply to the lower portion of abdominal aorta. The pressures proximal and distal to stenosis were 185/110 and 95/70 mmHg, and the pressure gradient across the stenosis was 90/40 mmHg. After the operation of thoraco-abdominal bypass graft, the pressure difference between the upper and lower extremities eventually disappeared.

  4. Cirurgia da aorta descendente e tóraco-abdominal com técnica de oclusão proximal isolada da aorta ("open distal" Surgical treatment of descending thoracic and thoracoabdominal aorta with the "open distal" technique

    Directory of Open Access Journals (Sweden)

    Bayard Gontijo Filho

    1995-09-01

    Full Text Available O presente relato apresenta a experiência obtida em um período de 4 anos (jan/91 - jan/95 com a técnica "open distal" descrita por Cooley, em 1990³, para tratamento cirúrgico de doenças da aorta torácica descendente e aorta tóraco-abdominal. Nesse período foram realizadas 35 operações (25 para aorta descendente e 10 para aorta tóraco-abdominal. Os aneurismas de origem degenerativa e as dissecções aórticas ocorreram em freqüência semelhante (48,5% e 40%, respectivamente; em 8 pacientes havia rotura da aorta, parcialmente tamponada pelo pulmão (5 casos, órgãos abdominais (2 casos e esófago (1 caso. O acesso cirúrgico foi obtido por toracotomia póstero-lateral esquerda ou tóraco-freno-laparotomia. Heparina foi usada na dose de 1,5 mg/kg e todo sangue do campo cirúrgico foi coletado a um reservatório e reinfundido pela veia femoral. Houve 4 (11.4% óbitos hospitalares e 2 (5,8% pacientes portadores de aneurisma tóraco-abdominal desenvolveram paraplegia. A morbi-mortalidade do grupo foi diretamente relacionada à condição clínica per-operatória e à extensão do segmento aórtico acometido. Na nossa opinião, a técnica "open distal" é um método alternativo simples e eficaz no tratamento cirúrgico das doenças da aorta descendente e tóraco-abdominal. Em casos de ressecções extensas com períodos longos de oclusão aórtica, métodos para proteção medular deverão ser avaliadosSince Jan/91 we have been using the "open distal" technique (ODT described by Cooley, for surgical treatment of diseases of the descending thoracic and thoracoabdominal aorta. From jan/91 to jan/95, the technique was used in 35 instances (25 for descending aorta and 10 for thoracoabdominal aorta. Degenerative aneurysms and aortic dissections had similar incidence in this group (48.5% and 40.0%, respectively. In 8 patients the aorta was ruptured which was partially occluded by the lung (5 cases, abdominal organs (2 cases and esophagus (1

  5. Transesophageal access to the cardiac cavities and descending thoracic aorta via echoendoscopy: An experimental study Acceso transesofágico a cavidades cardiacas y aorta torácica descendente mediante ecoendoscopia: Estudio experimental

    Directory of Open Access Journals (Sweden)

    A. López Martín

    2009-09-01

    trabajo pretenden evaluar la anatomía cardiaca, su abordaje, la seguridad del procedimiento experimental y los cambios morfológicos e histológicos derivados. Material y métodos: se ha trabajado con dos animales adultos de la especie porcina a los que se han practicado diversos abordajes a cavidades cardiacas y aorta torácica descendente con excelentes resultados. Resultados: se han identificado y abordado diversas estructuras cardiacas (aurícula derecha, aurícula izquierda, ventrículo izquierdo, válvulas cardiacas y grandes vasos. El uso de contraste intracavitario y desde una vía venosa periférica ha permitido asegurar los espacios anatómicos estudiados. Durante los procedimientos se ha monitorizado la aparición de arritmias, el comportamiento hemodinámico, la posibilidad de infección mediante la obtención de hemocultivos antes y después de aquellos y la respuesta a las punciones. Conclusiones: el presente trabajo nos ha permitido evaluar el acceso al corazón desde la luz esofágica mediante ultrasonografía endoscópica, con unos resultados muy similares a los observados en la literatura, ofreciendo dos novedades como la punción de la aurícula derecha a través del tabique interauricular y de la aorta torácica descendente, de forma fácil y aparentemente segura.

  6. El maxilar inferior del Orden Lagomorpha como material de investigación en Implantología Experimental

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    A De Corral Escobar

    2002-07-01

    Full Text Available El propósito de este trabajo es presentar un nuevo modelo experimental para el estudio de implantes en la mandíbula del conejo por la cara inferior o región milohioidea, donde se encuentra un tejido óseo en forma triangular, constituido por hueso compacto en superficie y trabecular en profundidad, semejante al del tejido alveolar del maxilar humano, que puede ser de interés como una nueva localización para estudiar la osteointegración de implantes. Se utilizaron 12 conejos europeos machos de 2.5 a 3 Kg, se colocaron un total de 12 implantes Dentatus® TRl de titanio de 8 mm y se realizó el estudio histológico con técnicas histoquímicas y tratamiento de imagen por ordenador.The aim of this paper was to show a new experimental model for the study of rabbit jaw implants on the lower face or mylohyoid region, where we founded bone tissue with triangular shape compound for compact bone tissue in surface and trabecular bone in depth, similar to human alveolar tissue of jaw, that should be interesting as a new location for implants osseointegration studies. We used 12 mal e European rabbits of 2.5 a 3 Kg weigh, were put a total of 12 titanium implants Dentatus® TRl of 8 mm long and hitological study with histochemical techniques and computer image treatment were done.

  7. Preliminary Geologic Map of the North-Central Part of the Alamosa 30' x 60' Quadrangle, Alamosa, Conejos and Costilla Counties, Colorado

    Science.gov (United States)

    Machette, Michael N.; Thompson, Ren A.; Brandt, Theodore R.

    2008-01-01

    This geologic map presents new polygon (geologic map unit contacts) and line (terrace and lacustrine spit/barrier bar) vector data for a map comprised of four 7.5' quadrangles in the north-central part of the Alamosa, Colorado, 30' x 60' quadrangle. The quadrangles include Baldy, Blanca, Blanca SE, and Lasauses. The map database, compiled at 1:50,000 scale from new 1:24,000-scale mapping, provides geologic coverage of an area of current hydrogeologic, tectonic, and stratigraphic interest. The mapped area is located primarily in Costilla County, but contains portions of Alamosa and Conejos Counties, and includes the town of Blanca in its northeastern part. The map area is mainly underlain by surficial geologic materials (fluvial and lacustrine deposits, and eolian sand), but Tertiary volcanic and volcaniclastic rocks crop out in the San Luis Hills, which are in the central and southern parts of the mapped area. The surficial geology of this area has never been mapped at any scale greater than 1:250,000 (broad reconnaissance), so this new map provides important data for ground-water assessments, engineering geology, and the Quaternary geologic history of the San Luis Basin. Newly discovered shoreline deposits are of particular interest (sands and gravels) that are associated with the high-water stand of Lake Alamosa, a Pliocene to middle Pleistocene lake that occupied the San Luis basin prior to its overflow and cutting of a river gorge through the San Luis Hills. After the lake drained, the Rio Grande system included Colorado drainages for the first time since the Miocene (>5.3 Ma). In addition, Servilleta Basalt, which forms the Basaltic Hills on the east margin of the map area, is dated at 3.79+or-0.17 Ma, consistent with its general age range of 3.67-4.84 Ma. This map provides new geologic information for better understanding ground-water flow paths in and adjacent to the Rio Grande system. The map abuts U.S. Geological Survey Open File Report 2005-1392 (a map of

  8. Management of bicuspid aortic valve with or without involvement of ascending aorta and aortic root.

    Science.gov (United States)

    Neragi-Miandoab, S

    2014-06-01

    Patients with a bicuspid aortic valve (BAV) constitute a heterogeneous population with variable clinical presentation and complications. More than 50% of the patients who require aortic valve replacement have a BAV, a condition that may be associated with dilation of ascending aorta and aortic insufficiency caused by cusp disease or aortic root pathology. Of the potential BAV-related complications, dilation of the aortic root and ascending aorta are among the most serious. The dilation of ascending aorta and aortic root have been the subject of controversy. Whereas some surgeons believe that the dilation of the aorta is caused by the hemodynamic properties of the BAV, others believe that the dilation of the aortic root is secondary to genetic defects associated with the BAV. Management of a BAV should be tailored to each patient's clinical condition. The surgical approach varies from aortic valve replacement to combined aortic valve and root replacement to aortic-valve-sparing root replacement.

  9. Combined aortic valve replacement and coronary artery bypass grafting for a calcified ascending aorta.

    Science.gov (United States)

    Baba, Hironori; Umesue, Masayoshi; Matsui, Kanzi

    2012-04-01

    Although a severely calcified ascending aorta is encountered infrequently, it presents formidable problems during cardiac surgery. We describe a case of severe aortic valve stenosis and coronary artery disease combined with a severely calcified ascending aorta. The patient was an 80-year-old man with a calcified ascending aorta. He successfully underwent an aortic valve replacement and a single coronary artery bypass graft (CABG) using a saphenous vein graft with the proximal end connected on a Dacron patch, which was used for aortoplasty of the calcified plate along the aortotomy. These procedures were performed under moderate hypothermia with aortic clamping. This patch aortoplasty can be a useful alternative in cases that require aortotomy and proximal anastomoses of a CABG on a calcified ascending aorta.

  10. [Giant pseudoaneurysm of the ascending aorta following the aortic valve replacement;report of a case].

    Science.gov (United States)

    Kawahara, Yu; Inage, Yuichi; Masaki, Naoki; Toyama, Shuji; Fukasawa, Manabu

    2013-08-01

    56-year-old male, who had undergone re-aortic valve replacement (AVR) 33 years ago, received preoperative study for pancreatic surgery. Computed tomography (CT) revealed a giant pseudoaneurysm (7 cm diameter) of the ascending aorta. The ascending aorta was not dilated. A midline skin incision was performed, followed by full sternotomy. A tight pericardial adhesion was carefully dissected. Cardiopulmonary bypass was established by femoral arterial and bicaval venous cannulation. The pseudoaneurysm was incised under the retrograde cardioplegic protection. A communication between ascending aorta and aneurysm was found 1 cm distal to the previous aortic suture line. This communication coincided with the cardioplegic root cannulation site. The aortic prosthetic valve was intact. The ascending aorta was replaced with 26 mm prosthetic graft. Postoperative course was uneventful. In this case, CT was useful to select the approach to the complicated postoperative surgical site.

  11. Magnetic resonance imaging of coarctation of the aorta and postoperative interrupted aortic arch

    Energy Technology Data Exchange (ETDEWEB)

    Kakizawa, Hideyuki; Tanaka, Takashi; Takada, Osamu; Nakayama, Shingo; Ogata, Hiroshi; Zuguchi, Masayuki (Tohoku Univ., Sendai (Japan). School of Medicine)

    1991-03-01

    ECG-gated MRI was performed at 1.5 T on 9 patients with coarctation of the aorta and restensis of the aorta after previous aortoplasty for coarctation of the aorta or interrupted aortic arch. The age of the patients ranged from 7 days to 3.3 years. MRI was more useful in assessing the severity of stenosis than echocardiography. Four patients had balloon dilation angioplasty for restenosis of the aorta. MRI was also useful in deciding the appropriate balloon size for angioplasty, and follow up after treatment. However, MRI could not always visualize the whole lesion in one slice, especially when the course of the aortic arch was not on the same plane. (author).

  12. Giant coronary cameral fistula with coarctation of aorta in a neonate

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    Neeraj Awasthy

    2015-01-01

    Full Text Available A coronary cameral fistula (CCF involves a sizable communication between a coronary artery and a cardiac chamber. We present a case of giant coronary cameral fistula associated with coarctation of aorta in a 13 days old neonate.

  13. Calcified congenital aneurysm of the left sinus of Valsalva associated with coarctation of the aorta

    Energy Technology Data Exchange (ETDEWEB)

    Paige, M.L.; Schwartz, D.C.

    1983-05-01

    A case of calcified unruptured congenital aneurysm of the left sinus of Valsalva associated with coarctation of the aorta is presented. Routine chest radiographs demonstrated unusual curvilinear calcifications at the cardiac base which were subsequently demonstrated within the aneurysm.

  14. Assessment of Blood Chemistry, Weight Gain and Linear Body Measurements of Pre-Puberal Buck Rabbits Fed Different Levels of Neem (Azadirachta indica A. Juss. Leaf Meals Evaluación de Química Sanguínea, Ganancia de Peso y Mediciones Corporales Lineales de Conejos Pre-Púberes Alimentados con Diferentes Niveles de Harina de Hojas de Neem (Azadirachta indica A. Juss.

    Directory of Open Access Journals (Sweden)

    I.P Ogbuewu

    2010-09-01

    Full Text Available A 16 week feeding trial was carried out to investigate the effect of dietary Neem (Azadirachta indica A. Juss. leaf meal (NLM on body weight gain, linear body measurements and blood chemistry of pre-puberal buck rabbits. Four treatment diets were formulated to contain the NLM at inclusion levels of 0 (control, 5, 10 and 15%. Thirty six crossbred New Zealand white × Chinchilla pre-puberal buck rabbits aged 5 to 6 mo were divided into four groups of nine rabbits and each group was further replicated into three of three rabbits each. The rabbits were randomly assigned to the four dietary treatments. Lymphocyte count of rabbits fed control diet (8.32 × 10(9 mm-3 was significantly higher than the group fed 15% NLM (4.60 × 10(9 mm-3. The mean cell hemoglobin (MCH and mean cell volume (MCV of the control bucks were significantly (p 0.05 among the treatment groups. The results suggest that buck rabbits could tolerate up to 15% dietary inclusion of NLM without deleterious effects on body weight gain, linear body measurements and some hematological parameters.Se realizó un ensayo de alimentación de 16 semanas para investigar el efecto de harina de hojas de neem Azadirachta indica A. Juss. (NML sobre ganancia de peso, mediciones corporales lineales y química sanguínea de conejos machos pre-púberes. Se formularon cuatro dietas con niveles de inclusión de NLM de 0 (control, 5, 10, y 15%. Treinta y seis conejos híbridos New Zealand white × Chinchilla, pre-púberes, de 5 a 6 meses, se distribuyeron en cuatro grupos de nueve conejos, y cada grupo fue repetido en tres grupos de tres conejos cada uno. Los conejos se asignaron aleatoriamente a las cuatro dietas tratamiento. El recuento de linfocitos de los conejos alimentados con la dieta control (8,32 × 10(9 mm-3 fue significativamente mayor que el grupo alimentado con 15% NLM (4,60 × 10(9 mm-3. La hemoglobina celular media (MCH y el volumen celular medio (MCV de los conejos control fueron

  15. Intramural hemorrhage of the thoracic aorta - imaging features and differential diagnosis; Das intramurale Haematom der thorakalen Aorta: Bildgebende Diagnostik und Differentialdiagnose

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, T. [Bonn Univ. (Germany) Radiologische Klinik; Abu-Ramadan, D. [Bonn Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Busch, M. [Bonn Univ. (Germany) Radiologische Klinik; Bierhoff, E. [Bonn Univ. (Germany). Pathologische Inst.; Kreft, B. [Bonn Univ. (Germany) Radiologische Klinik; Kuhl, C. [Bonn Univ. (Germany) Radiologische Klinik; Lutterbey, G. [Bonn Univ. (Germany) Radiologische Klinik; Keller, E. [Bonn Univ. (Germany) Radiologische Klinik; Schild, H. [Bonn Univ. (Germany) Radiologische Klinik

    1996-09-01

    Purpose: Aortic wall thickening due to intramural hemorrhage may be the only sign of aortic dissection. The aim of this study was to evaluate the incidence, imaging features and differential diagnoses of intramural hemorrhage (IMH) of the thoracic aorta. Methods: 98 patients with clinically suspected aortic dissection were investigated via Spiral-CT and MRT. Diagnosis of IMH based on the presence of smooth crescentic or concentric wall thickening over a longer segment of the thoracic aorta without flow visualization and without compression or distortion of the aortic lumen. Results: 69 patients had classic aortic dissections and 7 patients were diagnosed to have IMH of the thoracic aorta. One patient with IMH of the ascending aorta died of aortic rupture and subsequent pericardial tamponade 12 hours after onset of symptoms. In one patient with IMH of the descending aorta on initial examination, there was a progression of overt aortic dissection at follow-up after three weeks. In two patients with IMH of the descending aorta, wall thickening decreased in size at follow-up (10-15 weeks), whereas in one patient it remained unchanged. Conclusion: IMH of the aorta should be considered a precursor of aortic dissection. At follow-up IMH may decrease in size, rupture or progress to overt aortic dissection. (orig.) [Deutsch] Ziel: Eine aortale Wandverdichtung als Ausdruck eines intramuralen Haematoms kann die einzige Manifestation einer Aortendissektion sein. Ziel dieser Arbeit war die Evaluierung der Inzidenz, bildgebenden Aspekte und Differentialdiagnosen dieses in der deutschsprachigen Literatur wenig bekannten Krankheitsbildes. Methode: 98 Patienten mit klinischem Verdacht auf eine Aortendissektion wurden MR- und computertomographisch untersucht. Kriterium fuer das Vorliegen eines intramuralen Haematoms war der Nachweis einer laengerstreckigen aortalen Wandverdickung ohne Flussnachweis sowie ohne Konfigurationsaenderung des aortalen Lumens. Ergebnisse: 69 Patienten

  16. Mycotic aneurysm of the descending thoracic aorta: the role of transesophageal echocardiography.

    Science.gov (United States)

    Joffe, I I; Emmi, R P; Oline, J; Jacobs, L E; Owen, A N; Ioli, A; Najjar, D; Kotler, M N

    1996-01-01

    Mycotic aneurysms of the aorta are prone to rupture. Thus rapid and accurate diagnosis is essential so that surgical repair can be undertaken. We report a case of mycotic aortic aneurysm caused by mitral valve endocarditis. The aneurysm situated at the junction of the thoracoabdominal aorta was readily detected by transesophageal echocardiography. Computed tomography and aortography were complementary to transesophageal echocardiography in establishing the diagnosis. The patient underwent successful repair and acute inflammation of the aneurysm was present at histologic examination.

  17. Calcifications of the Thoracic Aorta on Extended Non-Contrast-Enhanced Cardiac CT

    OpenAIRE

    Damian Craiem; Gilles Chironi; Casciaro, Mariano E.; Sebastian Graf; Alain Simon

    2014-01-01

    BACKGROUND: The presence of calcified atherosclerosis in different vascular beds has been associated with a higher risk of mortality. Thoracic aorta calcium (TAC) can be assessed from computed tomography (CT) scans, originally aimed at coronary artery calcium (CAC) assessment. CAC screening improves cardiovascular risk prediction, beyond standard risk assessment, whereas TAC performance remains controversial. However, the curvilinear portion of the thoracic aorta (TA), that includes the aorti...

  18. Ruptured Sinus of Valsalva Aneurysm and Coarctation of Aorta in a Woman at Early Postpartum Period

    Directory of Open Access Journals (Sweden)

    Erol Sener

    2014-01-01

    Full Text Available Coarctation of aorta and sinus of Valsalva aneurysm are frequently missed congenital cardiac defects that their diagnosis might be delayed. To our knowledge, coincidence of these cardiac defects is unusual and has not been reported in the literature before. Here, we present a patient with coarctation of aorta and ruptured noncoronary sinus of Valsalva aneurysm leading to aorto-right atrial fistula in the early postpartum period and our management of this unusual case.

  19. Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

    Institute of Scientific and Technical Information of China (English)

    Francesco Fiz; Silvia Morbelli; Matteo Bauckneht; Arnoldo Piccardo; Giulia Ferrarazzo; Alberto Nieri; Nathan Artom; Manlio Cabria; Cecilia Marini; Marco Canepa; Gianmario Sambuceti

    2016-01-01

    AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F) uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS: Seventy-eight patients(44 females,mean age 63,range 44-83) underwent whole body 18F-Na F positron emission tomography/computed tomography. Cardiovascular risk(CVR) was used to divide these patients in three categories: Low(LR),medium(MR) and high risk(HR). 18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS: A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84 ± 0.76 vs 1.07 ± 0.3,P < 0.001),but also between MR and HR-LR(1.4 ± 0.4,P < 0.02 and P < 0.01,respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P < 0.01). Myocardial uptake provided an effective CVR classes stratification(P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R = 0.67),but it peaked when correlating the descending thoracic segment(R = 0.75),in comparison with the aortic arch and the ascending segment(R = 0.55 and 0.53,respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients’ risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination.

  20. Cannulation in the Diseased Aorta: A Safe Approach Using the Seldinger Technique

    OpenAIRE

    2006-01-01

    The Seldinger technique is a method of femoral cannulation that has been used to establish cardiopulmonary bypass. Reports of cannulation of the ascending aorta for antegrade perfusion using the Seldinger method are anecdotal. To the best of our knowledge, the approach described herein for direct cannulation of the ascending aorta with use of the Seldinger technique for antegrade perfusion has not been previously described in the English-language medical literature. This method is helpful whe...

  1. Pseudoaneurisma de la aorta torácica de origen traumático

    OpenAIRE

    2000-01-01

    Se presenta el caso de un paciente con ruptura traumática de aorta descendente y con la formación tardía de un pseudoaneurisma, el cual fue reparado mediante la utilización de un parche de duramadre.We report a patient whit traumatic rupture of de descending aorta and late presentation of a pseudoaneurism, in whom we repaired it with a duramater patch.

  2. Pseudoaneurisma de la aorta torácica de origen traumático

    Directory of Open Access Journals (Sweden)

    Eduardo Induni

    2000-08-01

    Full Text Available Se presenta el caso de un paciente con ruptura traumática de aorta descendente y con la formación tardía de un pseudoaneurisma, el cual fue reparado mediante la utilización de un parche de duramadre.We report a patient whit traumatic rupture of de descending aorta and late presentation of a pseudoaneurism, in whom we repaired it with a duramater patch.

  3. Fracaso del cartílago costal en el tratamiento de defectos óseos experimentales: Estudio histológico y radiológico

    OpenAIRE

    2003-01-01

    Se realiza un estudio experimental para demostrar la utilidad del cartílago costal, fresco o criopreservado (autólogo y homólogo), en el tratamiento de defectos óseos cavitarios de huesos largos y observar si la radiología simple es fiable para la valoración de su incorporación. Para ello se implanta cartílago costal, sin pericondrio, en un defecto óseo cavitario de la metáfisis distal del fémur de conejo. Se utilizan dos tipos de injerto según su procedencia (antólogo y homólogo) y el proced...

  4. Respuesta ósea a la vitrocerámica del sistema CASiO3 - SiO2 - Ca3(PO4) : estudio experimental "in vivo"

    OpenAIRE

    Clavel Rojo, Luis

    2011-01-01

    Se presenta un estudio “in vivo”, en conejos Nueza Zelanda, de una vitrocerámica del sistema CaSiO3-[CaSiO3 - Ca3(Si3O9)]-SiO2-Ca3(PO4). Se realizaron defectos óseos epifisarios de 6 x 4´5 mm donde se implantaron cilindros del material a estudio. Los animales se distribuyeron de forma aleatoria en 5 grupos de estudio según el tiempo de implantación previo al sacrifico. Cada muestra se analizó mediante estudio radiológico, histológico y de microscopia electrónica. Los resultados obtenidos dem...

  5. Mechanisms of traumatic rupture of the aorta and associated peri-isthmic motion and deformation.

    Science.gov (United States)

    Hardy, Warren N; Shah, Chirag S; Mason, Matthew J; Kopacz, James M; Yang, King H; King, Albert I; Van Ee, Chris A; Bishop, Jennifer L; Banglmaier, Richard F; Bey, Michael J; Morgan, Richard M; Digges, Kennerly H

    2008-11-01

    This study investigated the mechanisms of traumatic rupture of the aorta (TRA). Eight unembalmed human cadavers were tested using various dynamic blunt loading modes. Impacts were conducted using a 32-kg impactor with a 152-mm face, and high-speed seatbelt pretensioners. High-speed biplane x-ray was used to visualize aortic motion within the mediastinum, and to measure deformation of the aorta. An axillary thoracotomy approach was used to access the peri-isthmic region to place radiopaque markers on the aorta. The cadavers were inverted for testing. Clinically relevant TRA was observed in seven of the tests. Peak average longitudinal Lagrange strain was 0.644, with the average peak for all tests being 0.208 +/- 0.216. Peak intraluminal pressure of 165 kPa was recorded. Longitudinal stretch of the aorta was found to be a principal component of injury causation. Stretch of the aorta was generated by thoracic deformation, which is required for injury to occur. The presence of atherosclerosis was demonstrated to promote injury. The isthmus of the aorta moved dorsocranially during frontal impact and submarining loading modes. The aortic isthmus moved medially and anteriorly during impact to the left side. The results of this study provide a better understanding of the mechanisms associated with TRA, and can be used for the validation of finite element models developed for the examination and prediction of TRA.

  6. The value of anterior displacement of the abdominal aorta in diagnosing neuroblastoma in children

    Directory of Open Access Journals (Sweden)

    Jose Luiz de Oliveira Schiavon

    Full Text Available Abstract Objective: To determine the value of anterior displacement of the abdominal aorta, when present at any level or only at the level of the adrenal gland, contralateral to the mass, in diagnosing neuroblastoma on computed tomography or magnetic resonance imaging in children up to 7 years of age. Materials and Methods: Imaging examinations of 66 patients were classified by consensus as for the presence of anterior aorta displacement and were compared with the pathology report. Results: We found anterior abdominal aorta displacement in 26 (39.39% of the 66 patients evaluated. Among those 26 patients, we identified neuroblastoma in 22 (84.62%, nephroblastoma in 3 (11.54%, and Burkitt lymphoma in 1 (3.85%. The positive predictive value was 84.62%, and the specificity was 88.24%. The displacement of the aorta was at the adrenal level, contralateral to the mass, in 14 cases, all of which were attributed to neuroblastoma. Conclusion: When the abdominal aorta is displaced at the level of the adrenal gland, contralateral to the mass, it can be said that the diagnosis is neuroblastoma, whereas abdominal aorta displacement occurring at other abdominal levels has a positive predictive value for neuroblastoma of approximately 85%.

  7. Fluid dynamics of coarctation of the aorta and effect of bicuspid aortic valve.

    Science.gov (United States)

    Keshavarz-Motamed, Zahra; Garcia, Julio; Kadem, Lyes

    2013-01-01

    Up to 80% of patients with coarctation of the aorta (COA) have a bicuspid aortic valve (BAV). Patients with COA and BAV have elevated risks of aortic complications despite successful surgical repair. The development of such complications involves the interplay between the mechanical forces applied on the artery and the biological processes occurring at the cellular level. The focus of this study is on hemodynamic modifications induced in the aorta in the presence of a COA and a BAV. For this purpose, numerical investigations and magnetic resonance imaging measurements were conducted with different configurations: (1) normal: normal aorta and normal aortic valve; (2) isolated COA: aorta with COA (75% reduction by area) and normal aortic valve; (3) complex COA: aorta with the same severity of COA (75% reduction by area) and BAV. The results show that the coexistence of COA and BAV significantly alters blood flow in the aorta with a significant increase in the maximal velocity, secondary flow, pressure loss, time-averaged wall shear stress and oscillatory shear index downstream of the COA. These findings can contribute to a better understanding of why patients with complex COA have adverse outcome even following a successful surgery.

  8. Experimental investigation of the influence of the aortic stiffness on hemodynamics in the ascending aorta.

    Science.gov (United States)

    Gülan, Utku; Lüthi, Beat; Holzner, Markus; Liberzon, Alex; Tsinober, Arkady; Kinzelbach, Wolfgang

    2014-11-01

    A three-dimensional (3-D) pulsatile aortic flow in a human ascending aorta is studied to investigate the effect of the aortic stiffness on the flow field and turbulent fluctuating velocities in the ascending aorta. A nonintrusive optical measurement technique, 3-D particle tracking velocimetry (3D-PTV), has been applied to anatomically accurate phantoms under clinically realistic conditions. A compliant silicon phantom was used to mimic the healthy aorta, and a rigid model was used to imitate the pathological case that appears in aortas for example as a result of aging. The realistic models are transparent which allows optical access to the investigation domain, and the index of refraction was matched to avoid optical distortions. Our results revealed that the aortic stiffness leads to an increase in systolic velocity and a decrease in the Windkessel effect, which is associated with the diastolic blood pressure. Furthermore, we found that the turbulent kinetic energy is about an order of magnitude higher for the rigid aorta, that is, an increase in aortic stiffness increases the magnitude of turbulent fluctuating velocities. The spatial distribution of the flow velocity showed that the flow is more organized and coherent spiraling patterns develop for the compliant aorta which helps to dampen the influence of disturbed flow. Finally, we observed higher Lagrangian acceleration and hence higher instantaneous forces acting on blood particles in the stiff case which implies that aging and hence arterial stiffening provokes distinctive alterations in blood flow, and these alterations may cause pathological symptoms in the cardiovascular system.

  9. Prospective ECG-gated 320-row CT angiography of the whole aorta and coronary arteries

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yu.; Fan, Zhanming; Xu, Lei; Yang, Lin; Xin, Haiyan; Zhang, Nan [Capital Medical University, Department of Radiology, Beijing An Zhen Hospital, Beijing (China); Capital Medical University, Ministry of Education, The Key Laboratory of Remodeling-Related Cardiovascular Diseases, Beijing An Zhen Hospital, Beijing (China); Zhang, Zhaoqi [Capital Medical University, Department of Radiology, Beijing An Zhen Hospital, Beijing (China)

    2012-11-15

    To investigate the feasibility of using a prospective ECG-gated wide-volume protocol in CT angiography (CTA) of the whole aorta and coronary arteries (CA). A total of 61 consecutive patients with suspected acute aortic diseases underwent CTA of the whole aorta using a prospective ECG-gated wide-volume CT protocol without heart rate (HR) control. The exposure window was set at 40-50 % of R-R interval (HR {>=}70 bpm) or 70-80 % of R-R interval (HR <70 bpm) in a single heartbeat. The image quality of the ascending aorta, aortic valve and CA was evaluated for motion artefacts. The mean attenuation was measured at different levels of the aorta. The radiation dose and contrast medium volume were recorded. All of the examinations were performed successfully. The image quality was acceptable in the ascending aorta, aortic valve (100 %) and CA (94.4 %). The mean radiation dose was 18.42 {+-} 5.02 mSv. Of 61 patients, 14 were diagnosed with aortic aneurysm and 35 were diagnosed with aortic dissection or intramural haematoma. Coronary artery stenosis was detected in 12 patients. For patients with aortic diseases, CTA of the whole aorta using a prospective ECG-gated wide-volume protocol has the potential to provide additional information about the CA and aortic valve with lower radiation exposure. (orig.)

  10. The value of anterior displacement of the abdominal aorta in diagnosing neuroblastoma in children*

    Science.gov (United States)

    Schiavon, Jose Luiz de Oliveira; Caran, Eliana Maria Monteiro; Odone Filho, Vicente; Lederman, Henrique Manoel

    2016-01-01

    Objective To determine the value of anterior displacement of the abdominal aorta, when present at any level or only at the level of the adrenal gland, contralateral to the mass, in diagnosing neuroblastoma on computed tomography or magnetic resonance imaging in children up to 7 years of age. Materials and Methods Imaging examinations of 66 patients were classified by consensus as for the presence of anterior aorta displacement and were compared with the pathology report. Results We found anterior abdominal aorta displacement in 26 (39.39%) of the 66 patients evaluated. Among those 26 patients, we identified neuroblastoma in 22 (84.62%), nephroblastoma in 3 (11.54%), and Burkitt lymphoma in 1 (3.85%). The positive predictive value was 84.62%, and the specificity was 88.24%. The displacement of the aorta was at the adrenal level, contralateral to the mass, in 14 cases, all of which were attributed to neuroblastoma. Conclusion When the abdominal aorta is displaced at the level of the adrenal gland, contralateral to the mass, it can be said that the diagnosis is neuroblastoma, whereas abdominal aorta displacement occurring at other abdominal levels has a positive predictive value for neuroblastoma of approximately 85%. PMID:28100931

  11. Anestesia para cesariana em gestante com hipoplasia de aorta distal: relato de caso Anestesia para cesárea en embarazada con hipoplasia de aorta distal: relato de caso Anesthesia for cesarean section on a pregnant woman with hypoplasia of the distal aorta: case report

    Directory of Open Access Journals (Sweden)

    Leonardo de Andrade Reis

    2008-02-01

    ésico adequado à realização do ato cirúrgico.JUSTIFICATIVA Y OBJETIVOS: Anomalías vasculares maternas, potencialmente graves para el feto, pueden colocar en riesgo la perfusión uterina, suscitando cuidados mucho más puntuales por parte del equipo anestésico. El objetivo de este relato fue mostrar la conducta anestésica para operación en cesárea en una embarazada con hipoplasia de aorta distal, bien debajo de la emergencia de las arterias renales, con estenosis de la arteria renal y falta de arterias ilíacas. RELATO DEL CASO: Paciente de 30 años, 54 kg, en el 2° embarazo con una cesárea anterior sin intercurrencias. Durante la realización de ecografía de gestación en la 12ª semana se observó una interrupción de la aorta bien debajo de la salida de las arterias renales. A la paciente se le realizó cineangiocoronariografía que mostró hipoplasia de la aorta distal por debajo de las arterias renales, con ausencia de las arterias ilíacas. Durante la investigación clínica la paciente se mostró asintomática, con excepción de hipertensión arterial y claudicación a los grandes esfuerzos. La paciente fue sometida a la anestesia peridural continua, con titulación de la dosis anestésica necesaria para la realización de la cesárea. Inicialmente se inyectaron 50 mg de bupivacaína a 0,5% sin vasoconstrictor y 10 µg de sufentanil. Quince minutos después, la anestesia fue complementada con 25 mg más de bupivacaína a 0,5%, lo que fue suficiente para alcanzar un adecuado nivel de bloqueo. La cesárea transcurrió sin intercurrencias y el niño nació en buenas condiciones clínicas. CONCLUSIONES: El uso de anestesia peridural continua con dosis fraccionadas demostró ser una técnica anestésica segura para la realización de este procedimiento por reducir los riesgos de hipotensión arterial materna inherente al bloqueo espinal y también por minimizar la transferencia placentaria de fármacos que ocurren cuando se usa la anestesia general. La titulaci

  12. Effect of coarctation of the aorta and bicuspid aortic valve on flow dynamics and turbulence in the aorta using particle image velocimetry

    Science.gov (United States)

    Keshavarz-Motamed, Zahra; Garcia, Julio; Gaillard, Emmanuel; Maftoon, Nima; Di Labbio, Giuseppe; Cloutier, Guy; Kadem, Lyes

    2014-03-01

    Blood flow in the aorta has been of particular interest from both fluid dynamics and physiology perspectives. Coarctation of the aorta (COA) is a congenital heart disease corresponding to a severe narrowing in the aortic arch. Up to 85 % of patients with COA have a pathological aortic valve, leading to a narrowing at the valve level. The aim of the present work was to advance the state of understanding of flow through a COA to investigate how narrowing in the aorta (COA) affects the characteristics of the velocity field and, in particular, turbulence development. For this purpose, particle image velocimetry measurements were conducted at physiological flow and pressure conditions, with three different aorta configurations: (1) normal case: normal aorta + normal aortic valve; (2) isolated COA: COA (with 75 % reduction in aortic cross-sectional area) + normal aortic valve and (3) complex COA: COA (with 75 % reduction in aortic cross-sectional area) + pathological aortic valve. Viscous shear stress (VSS), representing the physical shear stress, Reynolds shear stress (RSS), representing the turbulent shear stress, and turbulent kinetic energy (TKE), representing the intensity of fluctuations in the fluid flow environment, were calculated for all cases. Results show that, compared with a healthy aorta, the instantaneous velocity streamlines and vortices were deeply changed in the presence of the COA. The normal aorta did not display any regions of elevated VSS, RSS and TKE at any moment of the cardiac cycle. The magnitudes of these parameters were elevated for both isolated COA and complex COA, with their maximum values mainly being located inside the eccentric jet downstream of the COA. However, the presence of a pathologic aortic valve, in complex COA, amplifies VSS (e.g., average absolute peak value in the entire aorta for a total flow of 5 L/min: complex COA: = 36 N/m2; isolated COA = 19 N/m2), RSS (e.g., average peak value in the entire aorta for a total flow of 5

  13. Ramos colaterais parietais e terminais da aorta abdominal em Myocastor coypus (nutria Terminal and parietal colateral branches of the abdominal aorta in Myocastor coypus (nutria

    Directory of Open Access Journals (Sweden)

    Paulete de Oliveira Vargas Culau

    2008-08-01

    Full Text Available Neste estudo, utilizaram-se 30 nutrias, 15 fêmeas e 15 machos, com o sistema arterial aórtico-abdominal preenchido com látex 603, pigmentado em vermelho, e fixado em uma solução aquosa de formaldeído a 20%. A aorta abdominal emitiu de sua superfície dorsal de 6 a 8 artérias lombares únicas. Das artérias renais, direita e esquerda, originaram-se as artérias frênico-abdominal para irrigar parte do diafragma e da parede abdominal lateral cranial. A aorta abdominal lançou dorsalmente, a artéria sacral mediana, cranialmente a sua bifurcação em artérias ilíacas comuns. As artérias ilíacas comuns, ramos terminais da aorta abdominal, originaram as artérias ilíacas interna e externa. A artéria ilíaca interna distribuiu-se nas vísceras da cavidade pélvica. A artéria ilíaca externa emitiu uma artéria umbilical e, antes de alcançar o anel femoral, lançou a artéria circunflexa ilíaca profunda para a parede abdominal lateral, em seus dois terços caudais. A artéria ilíaca externa lançou o tronco pudendo-epigástrico, que originou a artéria epigástrica caudal, para a parede abdominal ventral e a artéria pudenda externa, que saiu pelo canal inguinal, para irrigar a genitália externa. Os ramos parietais diretos da aorta abdominal foram as artérias lombares e a artéria sacral mediana, enquanto as artérias frênico-abdominal, circunflexa ilíaca profunda e epigástrica caudal, foram ramos colaterais parietais indiretos. Os ramos terminais da artéria aorta abdominal foram as artérias ilíacas comuns com seus ramos, as artérias ilíacas interna e externa.For this study it was used 30 nutria, 15 females and 15 males, with its abdominal aorta system full filled with latex 603, stained in red, and fixed in an aqueous solution of formaldehyde 20%. The abdominal aorta emitted from its dorsal surface 6 to 8 single lumbar arteries. From the renal arteries, left and right, it has been originated the phrenicoabdominal arteries

  14. Geologic map of the Ute Mountain 7.5' quadrangle, Taos County, New Mexico, and Conejos and Costilla Counties, Colorado

    Science.gov (United States)

    Thompson, Ren A.; Turner, Kenzie J.; Shroba, Ralph R.; Cosca, Michael A.; Ruleman, Chester A.; Lee, John P.; Brandt, Theodore R.

    2014-01-01

    The Ute Mountain 7.5' quadrangle is located in the south-central part of the San Luis Basin of northern New Mexico, in the Rio Grande del Norte National Monument, and contains deposits that record volcanic, tectonic, and associated alluvial and colluvial processes over the past four million years. Ute Mountain has the distinction of being one of the largest intermediate composition eruptive centers of the Taos Plateau, a largely volcanic tableland occupying the southern portion of the San Luis Basin. Ute Mountain rises to an elevation in excess of 3,000 m, nearly 700 m above the basaltic plateau at its base, and is characterized by three distinct phases of Pliocene eruptive activity recorded in the stratigraphy exposed on the flanks of the mountain and in the Rio Grande gorge. Unconformably overlain by largely flat-lying lava flows of Servilleta Basalt, the area surrounding Ute Mountain records a westward thickening of basin-fill volcanic deposits interstratified in the subsurface with Pliocene basin-fill sedimentary deposits derived from older Tertiary and Precambrian sources to the east. Superimposed on this volcanic stratigraphy are alluvial and colluvial deposits derived from the flanks of Ute Mountain and more distally-derived alluvium from the uplifted Sangre de Cristo Mountains to the east, that record a complex temporal and stratigraphic succession of Quaternary basin deposition and erosion. Pliocene and younger basin deposition was accommodated along predominantly north-trending fault-bounded grabens. These poorly exposed fault scarps cutting lava flows of Ute Mountain volcano. The Servilleta Basalt and younger surficial deposits record largely down-to-east basinward displacement. Faults are identified with varying confidence levels in the map area. Recognizing and mapping faults developed near the surface in young, brittle volcanic rocks is difficult because: (1) they tend to form fractured zones tens of meters wide rather than discrete fault planes, (2

  15. CFU-S(11) activity does not localize solely with the aorta in the aorta-gonad-mesonephros region.

    Science.gov (United States)

    de Bruijn, M F; Peeters, M C; Luteijn, T; Visser, P; Speck, N A; Dzierzak, E

    2000-10-15

    The aorta-gonad-mesonephros (AGM) region is a potent hematopoietic site in the midgestation mouse conceptus and first contains colony-forming units-spleen day 11 (CFU-S(11)) at embryonic day 10 (E10). Because CFU-S(11) activity is present in the AGM region before the onset of hematopoietic stem cell (HSC) activity, CFU-S(11) activity in the complex developing vascular and urogenital regions of the AGM was localized. From E10 onward, CFU-S(11) activity is associated with the aortic vasculature, and is found also in the urogenital ridges (UGRs). Together with data obtained from organ explant cultures, in which up to a 16-fold increase in CFU-S(11) activity was observed, it was determined that CFU-S(11) can be increased autonomously both in vascular sites and in UGRs. Furthermore, CFU-S(11) activity is present in vitelline and umbilical vessels. This, together with the presence of CFU-S(11) in the UGRs 2 days before HSC activity, suggests both temporally and spatially distinct emergent sources of CFU-S(11). (Blood. 2000;96:2902-2904)

  16. Overexpression of Vascular Endothelial Growth Factor in Restenotic Abdominal Aorta of Rabbits

    Institute of Scientific and Technical Information of China (English)

    尹瑞兴; 杨德寨; 吴海; 黄凯; 巫相宏; 陈宇明

    2002-01-01

    Objective To investigatethe expression of vascular endothelial growth factor (VEGF) in the wall of normal and restenotic abdominal aorta of rabbits. Methods Restenotic model was developed by balloon-injured abdominal aorta in eight male New Zealand White rabbits fed with a 2.0% cholesterol diet beginning two weeks before operation and continuing four weeks after procedure. At the end of 4 weeks after injury, the animals underwent total body perfusion fixation. Then, the abdominal aorta from iliac artery root to the diaphragm was harvested and post-fixed in 10 % neutral formalin for 16hours. Eight male animals fed with general diet were used for a normal control. The VEGF protein level in normal and restenotic abdominal aorta of rabbits was studied by means of immunohistochemistry. Results VEGF protein was detected in 5 (62.5 % ) of 8normal abdominal aorta, 3 showed faint staining, and the remaining 2 showed moderate VEGF expression.VEGF expression at the protein level was identified in all 8 restenotic specimens, 2 showed faint staining, 4showed moderate staining, and the remaining 2showed strong VEGF expression. In contrast to normal vessels, VEGF in restenotic specimens was distinctly expressed at sites that contained clustered macrophages and proliferating smooth muscle cells as well as endothelial cells. VEGF immunostaining was more extensive in restenotic specimens (2. 00 ± 0.76)than in normal vessels (0.82 ±0. 83, P < 0.01) .Microvessels were found in 7 of the 8 restenotic lesions, but only one lesion showed VEGF staining in endothelial cells of the microvessels. Conclusion VEGF expression is consistently more intense in sections of restenotic abdominal aorta than in those of normal abdominal aorta. The VEGF expressed by the smooth muscle cells and foamy macrophages in the restenotic arteries may act as a local and endogenous regulator of endothelial cell functions, including maintenance and repair of luminal endothelium, and formation of intimal

  17. Abdominal aorta coarctation: The first three case reports in our literature

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    Gajin Predrag

    2010-01-01

    Full Text Available Introduction. Congenital coarctation of the thoracic aorta at the ligamentum arteriosum or the aortic arch is well recognized. But a much less common variety (0.5-2.0% of aortic coarctation is located in the distal thoracic aorta or abdominal aorta or both and is often called 'middle aortic syndrome' or 'midaortic dysplastic syndrome'. This represents serious pathological condition and indicates multidisciplinary therapy approach. Outline of Cases. From 1996 to 2007, at the Vascular Surgery Clinic of the Institute for Cardiovascular Diseases 'Dedinje', Belgrade, three patients were treated due to abdominal aorta coarctation, two females aged 55 and 50 and a 4-year-old child. The patients were treated surgically (by-pass with a prosthetic graft and patch angioplasty and endovascular-percutaneous transluminal angioplasty (PTA with and without a stent. The follow-up period was 3-70 months. In the 50-year-old patient, angiography showed severe narrowing of the suprarenal segment of the abdominal aorta. Thoraco-abdominal bypass with a 16 mm dacronic tubular graft was performed. In the 4-year-old patient angiography also showed a suprarenal aorta narrowing. In the first act patch angioplasty was performed and after PTA of the visceral arteries was done on several occasions. In the 55-year-old patient, after diagnostic angiography, infrarenal aorta coarctation was registered. PTA was performed with stent placement. All patients were asymptomatic on control check-ups. Conclusion. Abdominal coarctation is a pathological disease which is seldom found in vascular surgery. Angiography is of major importance for setting the diagnosis and for the control of the results of surgical and nonsurgical treatment. The combination of surgical and endovascular treatment in our patients showed very good results in the studied period.

  18. Evaluation of the normal thoracic and abdominal aorta diameters by computerized tomography; Avaliacao dos diametros normais da aorta toracica e abdominal pela tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Lucarelli, Claudio Luiz

    1995-07-01

    The study was undertaken to evaluate, through computerized tomography, the diameters of the normal thoracic and abdominal aorta, as well as they are connected to gender, age and body surface area; and the ratio between measurements obtained at the ascending and descending limbs of the thoracic aorta, and between the abdominal aortic diameters. For that reason, we measured the widest anteroposterior diameters of the thoracic aortas at the levels of the arch, the root, the pulmonary artery, and the thoracic-abdominal transition, as well as the level of the emergence of the superior mesenteric artery, of the renal hila and just cephalad to the bifurcation of the abdominal aortas of 350 patients without cardiovascular diseases who had undergone computerized tomography of the thorax and/or abdomen for any other reasons. Observation and statistic analyses led us to conclude that: 1) both the thoracic and abdominal aortic diameters are reduced from their proximal to their distal portions; 2) the body surface influences the size of the aorta, although only extreme variations alter the vessel's caliber; 3) vessel diameter was observed to gradually increase with age; 4) men were found to have larger diameters than age matched women; 5) the ratio between the ascending and descending aortic diameters varies according to gender and age; 6) the relations between abdominal aortic diameters measured at the level of renal hila and cephalad to the bifurcation are independent from gender and age. But the relation between those measured at the level of the superior mesenteric artery and cephalad to the bifurcation are linked to gender, but not to age. (author)

  19. Análisis de la situación epidemiológica en una colonia de producción intensiva de conejos para la experimentación entre 1993 e 2007 - Analysis of the epidemiological situation in a colony of intensive production of rabbits for experimentation during 1993 and 2007

    Directory of Open Access Journals (Sweden)

    Pérez Martínez, Ileana

    2010-02-01

    Full Text Available ResumenEl conejo es una especie cotizada por el alto valor nutritivo de su carne, su fácil manejo y alta prolificidad, además puede ser utilizado en la investigación biomédica.SummaryThe rabbit is a species listed by the high nutritional value of their meat, easy handling and high prolificacy, and can be used in biomedical research.

  20. Prolonged flaxseed flour intake decreased the thickness of the aorta and modulates some modifiable risk factors related to cardiovascular disease in rats.

    Science.gov (United States)

    Cardozo, Ludmila Ferreira Medeiros de França; Vicente, Gabriela Câmara; Brant, Lívia Hipólito Cardozo; Mafra, Denise; Chagas, Maurício Alves; Boaventura, Gilson Teles

    2014-02-01

    Las enfermedades cardiovasculares son un problema de salud pública. Diferentes factores de riesgo han sido reconocidos como las principales causas del desarrollo y la progresión de las enfermedades cardiovasculares. La linaza es una fuente de fibra dietética, lignanos, y el ácido alfa-linolénico. El objetivo de este estudio fue evaluar los efectos de la suplementación prolongada con harina de linaza como tratamiento preventivo de los parámetros de riesgo cardiovascular en ratas Wistar saludables. Material y métodos: Ratas hembras Wistar fueron divididas en dos grupos después de dar a luz y durante el perío do de lactancia: el grupo de control fue alimentado con una dieta basada en caseína y el grupo de la linaza se alimentó con una dieta basada en caseína que contiene 25% de harina de linaza. Al destete, 10 ratas macho de la camada de cada grupo siguió recibiendo las mismas dietas de sus madres durante 250 días. El peso corporal, la masa grasa visceral, colesterol, triglicéridos, HDL, VLDL, la glucosa y el grosor de la aorta fueron analizado. Resultados: El peso corporal, la masa grasa visceral, colesterol, triglicéridos, HDL, VLDL, la glucosa y el grosor de la aorta esos valores fueron estadísticamente menor en comparación con el grupo control. Conclusión: Los datos sugieren que la suplementación con harina de linaza en ratas Wistar saludables durante un período prolongado puede disminuir el espesor de la aorta y puede ser utilizado como una medida preventiva en la modulación de algunos factores de riesgo modificables relacionados con la enfermedad cardiovascular.

  1. Transcatheter aortic valve implantation in patients with "porcelain" aorta (from a Multicenter Real World Registry).

    Science.gov (United States)

    Zahn, Ralf; Schiele, Rudolf; Gerckens, Ulrich; Linke, Axel; Sievert, Horst; Kahlert, Philipp; Hambrecht, Rainer; Sack, Stefan; Abdel-Wahab, Mohamed; Hoffmann, Ellen; Senges, Jochen

    2013-02-15

    The presence of severe atherosclerosis of the ascending aorta, and its extreme form the "porcelain" aorta, is associated with a worse clinical outcome in patients undergoing surgical aortic valve replacement. Percutaneous transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis can overcome this problem: 1,374 TAVI procedures were performed at 27 hospitals in 147 patients (10.7%) with and 1,227 (89.3%) without a porcelain aorta. The mean reported prevalence of a porcelain aorta at the hospitals was 7.8% ± 14.8% (range 0% to 70%). Diabetes mellitus (46.3% vs 33.2%, p = 0.00018), chronic obstructive pulmonary disease (43.5% vs 22.2%, p <0.0001), and peripheral arterial obstructive disease (34.7% vs 20.0%, p <0.0001) were more prevalent in patients with a porcelain aorta. In patients with a porcelain aorta, coronary ischemia occurred more often (2.0% vs 0.1%, p <0.0001), with a tendency toward a greater stroke rate (5.5% vs 2.8%, p = 0.08), greater in-hospital death rate (10.9% vs 8.1%, p = 0.24), and greater death or stroke rate (14.4% vs 10.2%, p = 0.12). On multivariate analysis, the presence of a porcelain aorta was not associated with in-hospital death (odds ratio 1.36, 95% confidence interval 0.72 to 2.55, p = 0.3441) nor in-hospital death or stroke (odds ratio 1.50, 95% confidence interval 0.81 to 2.47, p = 0.2207). In conclusion, in this real-world TAVI registry, a "porcelain" aorta was diagnosed in almost every tenth patient. Although differences were found in its frequency among the participating hospitals, the presence of a porcelain aorta was not associated with in-hospital death or stroke.

  2. Age-associated pro-inflammatory adaptations of the mouse thoracic aorta.

    Science.gov (United States)

    Hemmeryckx, Bianca; Hoylaerts, Marc F; Deloose, Eveline; Van Hove, Cor E; Fransen, Paul; Bult, Hidde; Lijnen, H Roger

    2013-10-01

    Arterial ageing may be associated with a reduction in vasodilation due to increased reactive oxygen species (ROS) production, whereas endothelial cell activation induces procoagulant changes. However, little is known on the effect of ageing on expression of anticoagulant endothelial markers such as endothelial protein C receptor (EPCR). To study age-associated alterations in smooth muscle cell (SMC) and endothelial cell (EC) structure and function, the aorta was isolated from 10-week- and 12- and 24-month-old C57BL/6J mice and analysed for its expression of genes involved in senescence, oxidative stress production, coagulation and matrix remodelling. In addition, vasorelaxation experiments were performed using 10-week- and 24-month-old thoracic aortic ring segments in organ chamber baths. The media thickness of the thoracic aorta progressively increased with age, associated with hypertrophy of vascular SMCs. Basal nitric oxide production and sensitivity to acetylcholine-mediated vasodilation in thoracic aorta rings was reduced with age, whereas no significant differences in ROS production could be demonstrated. Gene expression of tissue factor, EPCR and von Willebrand factor was not affected by ageing of the aorta, whereas that of thrombomodulin was mildly reduced and that of xanthine dehydrogenase, NADPH oxidase 4, tumour necrosis factor-α and vascular cell adhesion molecule-1 significantly enhanced. In conclusion, a reduction in endothelial cell-mediated vasodilation in aged thoracic aortas of C57BL/6J mice was accompanied by a shift towards a pro-inflammatory state of the endothelium.

  3. Polydimethylsiloxane embedded mouse aorta ex vivo perfusion model: proof-of-concept study focusing on atherosclerosis.

    Science.gov (United States)

    Wang, Xueya; Wolf, Marc P; Keel, Rahel Bänziger; Lehner, Roman; Hunziker, Patrick R

    2012-07-01

    Existing mouse artery ex vivo perfusion models have utilized arteries such as carotid, uterine, and mesenteric arteries, but not the aorta. However, the aorta is the principal vessel analyzed for atherosclerosis studies in vivo. We have devised a mouse aorta ex vivo perfusion model that can bridge this gap. Aortas from apoE((-/-)) mice are embedded in a transparent, gas-permeable, and elastic polymer matrix [polydimethylsiloxane (PDMS)] and artificially perfused with cell culture medium under cell culture conditions. After 24 h of artificial ex vivo perfusion, no evidence of cellular apoptosis is detected. Utilizing a standard confocal microscope, it is possible to image specific receptor targeting of cells in atherosclerotic plaques during 24 h. Imaging motion artifacts are minimal due to the polymer matrix embedding. Re-embedding of the aorta enables tissue sectioning and immuno-histochemical analysis. The ex vivo data are validated by comparison with in vivo experiments. This model can save animal lives via production of multiple endpoints in a single experiment, is easy to apply, and enables straightforward comparability with pre-existing atherosclerosis in vivo data. It is suited to investigate atherosclerotic disease in particular and vascular biology in general.

  4. Confiabilidade de um método de análise histológica da degeneração discal experimental em coelhos Confiabilidad de un método para el análisis histológico de la degeneración discal experimental en conejos Reliability of a method for histological analysis of experimental disc degeneration in rabbits

    Directory of Open Access Journals (Sweden)

    Emiliano Neves Vialle

    2011-01-01

    Full Text Available OBJETIVO: Validar um método para avaliação histológica da degeneração discal experimental em coelhos, baseando-se na confiabilidade da análise interobservador. MÉTODOS: Treze coelhos da raça New Zealand foram submetidos a procedimento de indução da degeneração discal através de punção direta de três discos intervertebrais (DIV consecutivos com agulha 18G sob anestesia. Ao fim de dois meses, coletou-se a coluna vertebral completa de cada coelho e procedeu-se preparo das peças para análise histológica dos discos intervertebrais (Experimentais e Controle, sendo coradas pelo método hematoxilina-eosina. As lâminas histológicas foram avaliadas quanto à ocorrência de degeneração através da análise dos seguintes critérios: presença de vasos sanguíneos; presença de protrusão do núcleo pulposo (NP através do ânulo fibroso (AF; e ruptura das fibras do AF. RESULTADOS: Ao final dos processos de eutanásia, retirada da coluna e preparo histológico, obteve-se 60 DIV viáveis para avaliação de degeneração. Deste total, 25 peças eram de DIV experimentais e 35 peças de DIV controle. A presença de vaso sanguíneo foi observada em 18 dos 25 DIV degenerados, com concordância de Kappa = 0,95 entre os observadores. A presença da extrusão do NP foi identificada em 19 dos 25 DIV experimentais, com concordância de Kappa = 0,78 entre os observadores. Com relação à ruptura das fibras do AF, pode-se identificar a positividade em 24 dos 25 DIV degenerados, com concordância entre os observadores de Kappa = 0,65. CONCLUSÃO: Este modelo de avaliação histológica da degeneração experimental do DIV mostrou-se viável, com alto grau de concordância entre os observadores na identificação da degeneração discal.OBJETIVO: Validar un método para evaluación histológica de la degeneración discal experimental en conejos, basándose en la confiabilidad del análisis interobservadores. MÉTODOS: Trece conejos de la raza New

  5. Spectrum analysis of turbulence in the canine ascending aorta measured with a hot-film anemometer.

    Science.gov (United States)

    Yamaguchi, T; Kikkawa, S; Tanishita, K; Sugawara, M

    1988-01-01

    We measured turbulence velocity in the canine ascending aorta using a hot-film anemometer. Blood flow velocity was measured at various points across the ascending aorta approximately 1.5-2 times the diameter downstream from the aortic valve. The turbulence spectrum was calculated and its characteristics were examined in connection with the mean Reynolds number and/or measuring positions. In the higher wave number range the values of the turbulence spectra were higher at larger mean Reynolds number. In the higher wave number range, the values of the turbulence spectra were higher at points closer to the centerline of the aorta, when the mean Reynolds number was relatively large. The patterns of the turbulence spectra at various points outside the boundary layer on the aortic wall were similar.

  6. Thrombosis of abdominal aorta during cisplatin-based chemotherapy of testicular seminoma - a case report

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    Gehrckens Ralf

    2009-12-01

    Full Text Available Abstract Background Vascular complications occurring during cisplatin-based chemotherapy of germ cell tumours are inadequately recognized to date. Case Presentation A 49 year old man with advanced seminoma underwent two courses of chemotherapy according to the PEB regimen. Upon restaging, two thrombotic deposits were noted in the descending part of the thoracic aorta and in the infrarenal abdominal aorta, respectively. Although thrombotic plaques caused aortic occlusion of about 30%, no clinical signs of malperfusion of limbs were registered. The patient was placed on anticoagulant therapy. Six months after completion of chemotherapy, thrombotic deposits had completely resolved. In the absence of other predisposing factors, it must be assumed that cisplatin-based chemotherapy represented a strong stimulus for arterial thrombosis in the aorta. Conclusions This is the first case of endo-aortic thrombosis during chemotherapy for testicular germ cell cancer. Providers of chemotherapy must be aware of arterial thrombosis even in young patients with testicular cancer.

  7. Forensic medical evaluation age-related changes aorta and pair large arteries

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    Efimov А.А.

    2015-06-01

    Full Text Available Objective: differentiation of age-dependence indices of aorta, carotid, brachial, femoral arteries and drawing the mathematical model for forensic age determinations on their basis. Material and methods. Objects were: aorta, fragments of right and left carotid, brachial and femoral arteries taken in a complex of 186 male and female corpses, died at the age of 17-94. Research methods consisted of organometrical, histological, micrometrical, correlative and regressive analysis. The Results. Correlative and regressive analysis of 35 indicators of aorta, carotid, brachial and femoral arteries was conducted. All material was divided into figures with a significant correlation with age and performance of age-independent. The mathematical model was composed for calculation of age. Conclusion. Indicated involution of arterial wall and compiled on the basis of a mathematical model for determination the age could be taken as the basis for forensic method of age determination.

  8. Vector flow imaging of the ascending aorta. Are systolic backflow and atherosclerosis related?

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Kjaergaard, Jesper

    2015-01-01

    In the ascending aorta, atherosclerotic plaque formation, which is a risk factor for cerebrovascular events, most often occurs along the inner curvature. Atherosclerosis is a multifactorial disease, but the predilection site for the aortic vessel degradation is probably flow dependent. To better...... understand the aortic flow and especially the complex flow patterns, the ascending aorta was scanned intraoperatively in patients undergoing heart surgery using the angle-independent vector velocity ultrasound method Transverse Oscillation (TO). The primary aim of the study was to analyze systolic backflow...... on the ascending aorta in long axis view. The presence of systolic backflow, visualized with TO, was correlated to aortic atherosclerosis, to systolic velocities obtained with transesophageal echocardiography and cardiac output obtained with pulmonary artery catheter thermodilution, to gender, age, aortic diameter...

  9. Aorta após endoprótese para aneurisma micótico

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    Ufuk Alpagut

    2011-10-01

    Full Text Available Endopróteses vasculares são atualmente utilizadas no tratamento de diferentes patologias da aorta. Podem salvar a vida de pacientes com comorbidades e virtualmente inoperáveis quando da utilização de técnicas convencionais. Esse manuscrito relata o caso de um paciente de 40 anos, que havia sido previamente tratado de um aneurisma micótico sacular no arco aórtico e que apresentou ruptura da aorta descendente no seguimento de médio prazo. O tratamento da ruptura da aorta descendente também foi realizado através de medidas endovasculares, com sucesso.

  10. Huge Dissected Ascending Aorta Associated with Pseudo Aneurysm and Aortic Coarctation Feridoun

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    Feridoun Sabzi

    2015-10-01

    Full Text Available We report a unique case of chronic dissection of the ascending aorta complicated with huge and thrombotic pseudoaneurysm in a patient with coarctation of descending aorta. Preoperative investigations such as transesophageal echocardiography (TEE confirmed the diagnosis of dissection. Intraoperative findings included a12 cm eccentric bulge of the right lateral side of dilated the ascending aorta filled with the clot and a circular shaped intimal tear communicating with an extended hematoma and dissection of the media layer. The rarity of the report is an association of the chronic dissection with huge pseudoaneurysm and coarctation. The patient underwent staged repair of an aneurysm and coarctation and had an uneventful postoperative recovery period.

  11. Endovascular stent for coarctation of the aorta in a child and review of the literature.

    Science.gov (United States)

    Cheng, Hsu-Ting; Lin, Ming-Chih; Jan, Sheng-Ling; Fu, Yun-Ching

    2011-08-01

    An 11-year-old, 35-kg boy underwent balloon angioplasty twice, at the ages of 4 years and 10 years, with only limited effect. He was admitted for another cardiac catheterization because of chest pain and breathlessness on exercise. Aortography revealed severe discrete coarctation of the aorta, with the narrowest diameter of 6mm. The pressures of the ascending aorta and descending aorta were 115/72mmHg and 93/66mmHg, respectively. After implantation of a 16-mm-diameter stent, the systolic pressure gradient decreased from 22mmHg to 0mmHg. Annual follow-up for 6 years showed normal blood pressure, no exercise intolerance, and no recoarctation.

  12. Tuberculous aneurysm of the abdominal aorta: endovascular repair using stent grafts in two cases

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Wei Chiang; Kwak, Byung Kook; Kim, Kyo Nam [Sung Ae General Hospital, Seoul (Korea, Republic of); And Others

    2000-12-01

    Tuberculous aneurysm of the aorta is exceedingly rare. To date, the standard therapy for mycotic aneurysm of the abdominal aorta has been surgery involving in-situ graft placement or extra-anatomic bypass surgery followed by effective anti-tuberculous medication. Only recently has the use of a stent graft in the treatment of tuberculous aortic aneurysm been described in the literature. We report two cases in which a tuberculous aneurysm of the abdominal aorta was successfully repaired using endovascular stent grafts. One case involved is a 42-year-old woman with a large suprarenal abdominal aortic aneurysm and a right psoas abscess, and the other, a 41-year-old man in whom an abdominal aortic aneurysm ruptured during surgical drainage of a psoas abscess. (author)

  13. Beat Pressure and Comparing it with Ascending Aorta Pressure in Normal and Abnormal Conditions

    CERN Document Server

    Ghasemalizadeh, Omid; Firoozabadi, Bahar; Sajadi, Behrang; Zolfonoon, Ali

    2014-01-01

    Lumped method (Electrical analogy) is a quick and easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that could show hydrodynamic parameters of cardiovascular system. Also this paper includes modeling of pulmonary, atrium, left and right ventricles with their equivalent circuits. Exact modeling of right and left ventricles pressure with division of ascending aorta into 27 segments increases the accuracy of our simulation. In this paper we show that a calculated pressure for aorta from our complex circuit is near to measured pressure by using advanced medical instruments. Also it is shown that pressure graph from brachial is so near to aortic pressure because of this its pressure signal is usable instead of aortic pressure. Furthermore, obstruction in ascending aorta, brachial and its effects has been showed in different figures.

  14. Alteration of time-resolved autofluorescence properties of rat aorta, induced by diabetes mellitus

    Science.gov (United States)

    Uherek, M.; Uličná, O.; Vančová, O.; Muchová, J.; Ďuračková, Z.; Šikurová, L.; Chorvát, D.

    2016-10-01

    Changes in autofluorescence properties of isolated rat aorta, induced by diabetes mellitus, were detected using time-resolved fluorescence spectroscopy with pulsed ultraviolet (UV) laser excitation. We demonstrated that time-resolved spectroscopy was able to detect changes in aorta tissues related to diabetes and unambiguously discriminate diabetic (τ 1 0.63  ±  0.05 ns, τ 2 3.66  ±  0.10 ns) samples from the control (τ 1 0.76  ±  0.03 ns, τ 2 4.48  ±  0.15 ns) group. We also report changes in the ratio of relative amplitudes of the two lifetime component in aorta tissue during diabetes, most likely related to the pseudohypoxic state with altered NADH homeostasis.

  15. Mechanical characterization of human aortas from pressurization testing and a paradigm shift for circumferential residual stress.

    Science.gov (United States)

    Labrosse, Michel R; Gerson, Eleanor R; Veinot, John P; Beller, Carsten J

    2013-01-01

    Material properties needed for accurate stress analysis of the human aorta are still incompletely known, especially as many reports have ignored the presence of residual stresses in the aortic wall. To contribute new material regarding these issues, we carried out measurements and pressurization testing on ascending, thoracic and abdominal aortic samples from 24 human subjects aged 38-77 years, and evaluated the opening angle describing the circumferential residual stress level present in the aorta. We determined material constants for the aorta by gender, anatomic location and age group, according to a simple phenomenological constitutive model. The unpressurized aortic radius positively correlated with age, and the circumferential and longitudinal stretch ratios under systemic pressure negatively correlated with age, confirming the known enlargement and stiffening of the aorta with aging. The opening angle was measured to range from a minimum of 89° to above 360° for extreme cases. For given aortic dimensions and material properties, analysis of the in vivo circumferential and longitudinal mural stress distributions indicated a profound influence of the opening angle. For instance, in the thoracic aorta of males aged 38-66, opening angles in the range of 0° to 80° (resp. 60°) may equalize the gradient of in vivo circumferential (resp. longitudinal) stress between the inner and outer layers of the aorta, as commonly expected; however, opening angles above 160° (resp. 120°) may cause the gradient of circumferential (resp. longitudinal) stress to reverse and increase compared to the case without residual stress, putting the maximum stresses toward the adventitia instead of the intima. Even though the analysis of the aortic wall excluded possible longitudinal residual stresses as well as material inhomogeneities, such as constitutive differences between the intimal, medial and adventitial layers, the experimental data reported herein are important to aortic

  16. Endovascular stents for coarctation of aorta in children and adolescents: early and intermediate- term results

    Directory of Open Access Journals (Sweden)

    Mortezaeian Langroodi H

    2010-09-01

    Full Text Available "nBackground: Coarctation of aorta is narrowing of proximal descending aorta. Interventional procedures such as balloon angioplasty & stent implantation has been progressively in use as alternatives for surgery in increasing number of children with diagnosis of coarctation of aorta. The aim of this study was to evaluate the use of endovascular stent in children with coarctation of aorta."n "nMethods: We evaluated effectiveness and safety of stenting in all patients younger than 18 years old with coarctation and re-coarctation of aorta which treated by stenting between years 2004-9 at rajaei - heart centre in Tehran, Iran. "n "nResults: we studied 53 patients younger than 18 years old with a follow up of six months. Totally 54 stents were implanted. Mean (±SD age of the patients was 11.6±4.2yrs. Seventeen cases (32% were younger than 10 years old, and 36 cases (68% were 10 years and older. Mean (±SD weight was 39.24±18kg. 16 cases weighting less than 25kg. Peak systolic pressure gradient (SPG decreased from 46.26±17.07 to 1.03±0.19mmHg after procedure (p<0.001. There was no significant difference (p<0.001 in the gradient before and after stenting in the patients with native coarctation (Vs re-coarctation cases, less than 25 kg and under 10 years old groups. Complications developed in 44% of cases while dominantly were minor except in two cases re-dilatation of stent was not needed during six month of follow-up of the patients."n "nConclusions: Stenting of coarctation of aorta can decrease complications and can be used safely in children weighing bellow 25kg and in children below 10yrs old.

  17. New device for saphenous vein-to-aorta proximal anastomosis without side-clamping

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    Tappainer Ernesto

    2007-05-01

    Full Text Available Abstract Background Side clamping to perform saphenous vein-to-aorta proximal anastomosis is a well known cause of cerebral embolization during coronary bypass surgery. Automatic and manual devices have been introduced to avoid aortic clamping and facilitate proximal anastomosis but the manual ones only allow the traditional hand-sewing running suture. Nevertheless, they are not easy to use and very expensive to buy. Methods We developed a simple object that helps to perform a manual proximal anastomosis without the need to clamp the side of the aorta. This device is a steel bar which blocks the aortic hole and simultaneously it provides a slit to receive the needle. Through the slit comes out a thin, sharp, straight, but also well directed and predictable jet of blood which could be easily controlled during the suture. Results The function of the object is quite different from other devices. Nothing is deployed in the aorta. The object is only placed on the aorta with the small appendage slipped into the hole. The main advantage of the device is that while manipulation of the aorta is avoided no foreign bodies are incorporated in the suture and – most importantly – the aortic intima is not touched at all. The main drawback of the device is the blood jet coming from the slit so that the blood pressure has to be lowered by vasodilators during the anastomosis. Moreover, the suture has to change direction and the needle has to enter the aortic wall first to slip out through the slit. Conclusion The object was named "Slit Device" and is not a routine instrument. It would be only an alternative to other anastomotic devices with the same surgical indications. In the case of ascending aortic disease and saphenous vein grafting, the Slit Device avoids aortic clamping thereby preventing atheroembolism and also avoiding the need for hypothermic circulatory arrest in patients with unclampable aorta.

  18. Ovariectomy increases the participation of hyperpolarizing mechanisms in the relaxation of rat aorta.

    Directory of Open Access Journals (Sweden)

    Ana Sagredo

    Full Text Available This study examines the downstream NO release pathway and the contribution of different vasodilator mediators in the acetylcholine-induced response in rat aorta 5-months after the loss of ovarian function. Aortic segments from ovariectomized and control female Sprague-Dawley rats were used to measure: the levels of superoxide anion, the superoxide dismutases (SODs activity, the cGMP formation, the cGMP-dependent protein kinase (PKG activity and the involvement of NO, cGMP, hydrogen peroxide and hyperpolarizing mechanisms in the ACh-induced relaxation. The results showed that ovariectomy did not alter ACh-induced relaxation; incubation with L-NAME, a NO synthase inhibitor, decreased the ACh-induced response to a lesser extent in aorta from ovariectomized than from control rats, while ODQ, a guanylate cyclase inhibitor, decreased that response to a similar extent; the blockade of hyperpolarizing mechanisms, by precontracting arteries with KCl, decreased the ACh-induced response to a greater extent in aortas from ovariectomized than those from control rats; catalase, that decomposes hydrogen peroxide, decreased the ACh-induced response only in aorta from ovariectomized rats. In addition, ovariectomy increased superoxide anion levels and SODs activity, decreased cGMP formation and increased PKG activity. Despite the increased superoxide anion and decreased cGMP in aorta from ovariectomized rats, ACh-induced relaxation is maintained by the existence of hyperpolarizing mechanisms in which hydrogen peroxide participates. The greater contribution of hydrogen peroxide in ACh-induced relaxation is due to increased SOD activity, in an attempt to compensate for increased superoxide anion formation. Increased PKG activity could represent a redundant mechanism to ensure vasodilator function in the aorta of ovariectomized rats.

  19. Comparación entre heridas por proyectiles de fuego calibre .22 de baja velocidad y de aire comprimido calibre .177 sobre flanco derecho de cadáveres frescos de conejos (Wounds produces by fire projectils caliber .22 low velocity and air compressed caliber.177 on right side of fresh dead rabbits. a trial study

    Directory of Open Access Journals (Sweden)

    Bimonte, D.

    2009-09-01

    Full Text Available ResumenEl objetivo del trabajo fue comparar, los efectos de proyectiles .177 Airecomprimido (AC, y .22 Rimfire Baja Velocidad (LV sobre tejidos óseos ymusculares, utilizando n=12 cadáveres frescos de conejos de 3 kilogramosde peso, (Oriyctolagus cuniculus híbridos Línea Genética Verde divididos endos grupos: (n=6 para .22 Rimfire (LV, peso 2,68 gramos velocidad inicialde 325 m/s y energía inicial 137 Julios y n=6 para .177 AC peso de 0,475gramos, velocidad de 138 m/s y Energía inicial de 4,54Julios.;suspendidos para simular condiciones reales de impacto. El diseñoexperimental fue aprobado por Comisión de Bioética, Facultad deVeterinaria, Universidad de la República, Uruguay. Ensayo de penetraciónrealizados en el Club Uruguayo de Tiro. A la necropsia se describieron laslesiones sobre tejidos musculares, huesos y órganos huecos, así como lascaracterísticas de los orificios de entrada (OE y de salida (OS, para cadatipo de munición y propulsión. Se halló que los disparos producidos pormunición. 22 Rimfire (LV producían fracturas de huesos largos mientrasque para el calibre .177 (AC usado no se registraron fracturas. Loshallazgos en órganos viscerales (toráxicos y abdominales fueron letalespara cualquiera de los dos tipos de munición disparada a 16 m. Solo en elcaso de la munición .177 (AC se encontraron los proyectiles alojados en pared del flanco opuesto al del ingreso. El proyectil .22 Rimfire (LV traspasa ambos flancos. Ambos tipos de proyectiles disparados a unadistancia de 16 metros, son capaces de producir lesiones letales.SummaryThe objective of this paper was to make a comparison the effectsproduced by projectiles .177 Air compressed (AC and .22 Rimfire Lowvelocity (LV on muscular and osseous tissues, using n=12 recently deadrabbit 3 kilogramos of weight, (Oriyctolagus cuniculus hybrid Greengenetical line divided in two groups: (n=6 for .22 Rimfire (LV, weight2,68 grams, initial velocity 325 m/s y initial energy 137

  20. CFD analysis of multiphase blood flow within aorta and its thoracic branches of patient with coarctation of aorta using multiphase Euler - Euler approach

    Science.gov (United States)

    Ostrowski, Z.; Melka, B.; Adamczyk, W.; Rojczyk, M.; Golda, A.; Nowak, A. J.

    2016-09-01

    In the research a numerical Computational Fluid Dynamics (CFD) model of the pulsatile blood flow was created and analyzed. A real geometry of aorta and its thoracic branches of 8-year old patient diagnosed with a congenital heart defect - coarctation of aorta was used. The inlet boundary condition were implemented as the User Define Function according to measured values of volumetric blood flow. The blood flow was treated as multiphase: plasma, set as the primary fluid phase, was dominant with volume fraction of 0.585 and morphological elements of blood were treated in Euler-Euler approach as dispersed phases (with 90% Red Blood Cells and White Blood Cells as remaining solid volume fraction).

  1. Effect of camelina oil on the structure of aortas in rats

    DEFF Research Database (Denmark)

    Pawlowska, Marta; Harrison, Adrian; Piersiak, Tomasz

    2016-01-01

    the treated rats received camelina oil at doses of 5 g/kg/b.w. (OVX2) or 9 g/kg/b.w. (OVX3) once a day. The rats were euthanized 7 weeks after the surgery, and the aorta, before the right and left common iliac arteries, was removed, cut into 5 mm pieces and exposed to a series of step-wise increases...... in tension. Aortic wall elasticity was measured in duplicate. Samples of the aorta were also prepared for histology (total aortic wall thickness, thickness of tunica intima and media, thickness of adventitia) and immunohistochemistry (volume and mean fluorescence intensity of collagens I and III and elastin...

  2. Aorta-to-right atrium fistula, an unusual complication of endocarditis

    Institute of Scientific and Technical Information of China (English)

    Miao-yan CHEN; Dan-dan ZHONG; Zhi-qiang YING

    2009-01-01

    Infective endocarditis (IE) remains a serious disease. Aorta-to-right atrium fistula is a rare but very serious compli-cation of IE and predicts a higher mortality. This report describes a 50-year-old man with endocarditis, vegetation, perforation of noncoronary sinus, and formation of two aorta-to-right atrium fistulas with native valves detected by transthoracic echocardi-ography. This disease is lethal despite developments in cardiac imaging and antibacterial therapy. Early diagnosis, aggressive antibacterial therapy, and surgical treatment may improve the prognosis.

  3. Coarctation of the aorta and renal artery stenosis in tuberous sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Flynn, P.M.; Robinson, M.B.; Stapleton, F.B.; Roy, S. III; Koh, G.; Tonkin, I.L.D.

    1984-07-01

    Among neurocutaneous disorders, coarctation of the abdominal aorta and renal artery stenosis have traditionally been associated with neurofibromatosis. We report a 5-year-old girl who was discovered to have bilateral renal artery stenosis, coarctation of the abdominal aorta, renal cysts and typical skin lesions of tuberous clerosis during the evaluation of asymptomatic hypertension. Renal vascular hypertension has not been reported previously in tuberous sclerosis. We conclude that the tuberous sclerosis complex should be expanded to include vascular malformations and the hypertension should not be assumed to be secondary to renal hamartomata or cysts in patients with tuberous sclerosis.

  4. Traumatic dissection and rupture of the abdominal aorta as a complication of the Heimlich maneuver.

    Science.gov (United States)

    Desai, Shaun C; Chute, Dennis J; Desai, Bharati C; Koloski, Eugene R

    2008-11-01

    Although the Heimlich maneuver is considered the best intervention for relieving acute upper airway obstruction, several complications have been reported in the literature. These complications can occur as a result of an increase in abdominal pressure leading to a variety of well-documented visceral injuries, including the great vessels. Acute abdominal aortic thrombosis after the Heimlich maneuver is a rare but recognized event; however, to date no case of traumatic dissection and rupture of the abdominal aorta has been described. We report the first known case, to our knowledge, of a traumatic dissection and rupture of the abdominal aorta after a forcefully applied Heimlich maneuver.

  5. Minimally invasive retrieval of patent foramen ovale closure device after device migration to the descending aorta.

    Science.gov (United States)

    Basoor, Abhijeet S; Cotant, John F; Halabi, Abdul R; DeGregorio, Michele; Chughtai, Haroon; Patel, Kiritkumar C

    2012-01-01

    Percutaneous treatment of patent foramen ovale with a septal closure device has become a common procedure, but it is associated with various complications. Migration of the device is uncommon, and migration through the aortic valve into the aorta is rare. Managing the migration of a patent foramen ovale occluder can be challenging; it usually requires surgical retrieval of the foreign body. We report a rare case in which a patient experienced migration of a large patent foramen ovale closure device to the descending aorta. Rarer still was its successful percutaneous management.

  6. Thoracic aorta aneurysm open repair in heart transplant recipient; the anesthesiologist′s perspective

    Directory of Open Access Journals (Sweden)

    Fabrizio Monaco

    2016-01-01

    Full Text Available Many years following transplantation, heart transplant recipients may require noncardiac major surgeries. Anesthesia in such patients may be challenging due to physiological and pharmacological problems regarding allograft denervation and difficult immunosuppressive management. Massive hemorrhage, hypoperfusion, renal, respiratory failure, and infections are some of the most frequent complications related to thoracic aorta aneurysm repair. Understanding how to optimize hemodynamic and infectious risks may have a substantial impact on the outcome. This case report aims at discussing risk stratification and anesthetic management of a 54-year-old heart transplant female recipient, affected by Marfan syndrome, undergoing thoracic aorta aneurysm repair.

  7. CA-45(2+) MOVEMENTS INDUCED BY CA2+ CHLORIDE IN ISOLATED RAT AORTA UNDER K+-FREE CONDITIONS

    NARCIS (Netherlands)

    WERMELSKIRCHEN, D; NEBEL, U; WIRTH, A; WILFFERT, B

    1991-01-01

    Increasing the extracellular Ca2+ concentration induced a dihydropyridine-insensitive contraction in the isolated rat aorta bathed in K+-free solution. To obtain further insight into the mechanism of this contraction Ca-45(2+) uptake measurements were carried out with isolated rat aorta. Increasing

  8. 45Ca2+movements induced by Ca2+chloride in isolated rat aorta under K+-free conditions

    NARCIS (Netherlands)

    Wermelskirchen, D.; Nebel, U.; Wirth, A.; Wilffert, B.

    1991-01-01

    Increasing the extracellular Ca2+concentration induced a dihydropyridine-insensitive contraction in the isolated rat aorta bathed in K+-free solution. To obtained further insight into the mechanisms of this contraction45Ca2+uptake measurements were carried out with isolated rat aorta. Increasing the

  9. Diagnosis of a perforating aneurysm of the aorta as late complication of patch aortoplasty by central venous DSA

    Energy Technology Data Exchange (ETDEWEB)

    Zitzmann, A.; Kreuzer, E.; Huber, R.M.; Kenn, R.W.; Pfeifer, K.J.

    1988-06-01

    11 years after patch aortoplasty due to coarctation of the aorta a 33 year-old-patient experienced two spontaneous haemoptyses. A centralvenous digital subtraction angiography demonstrated a large aneurysm of the proximal descending aorta penetrating the left upper lobe of the lung. The successful emergency surgical treatment consisted of implantation of a dacron-prothesis.

  10. Signal transduction pathways involved in particulate matter induced relaxation in rat aorta--spontaneous hypertensive versus Wistar Kyoto rats.

    NARCIS (Netherlands)

    Bagate, Karim; Meiring, James J; Gerlofs-Nijland, Miriam E; Cassee, Flemming R; Borm, Paul J A

    2006-01-01

    Previously we reported that in vivo exposure to ambient particulate matter (PM) induces vasodilatation in rat aorta. The purpose of the current study was to investigate the intracellular messengers involved in PM-elicited vasodilatation in aortas from spontaneous hypertensive (SHR) and normotensive

  11. New parameters to represent the position of the aorta relative to the spine for pedicle screw placement.

    Science.gov (United States)

    Takeshita, Katsushi; Maruyama, Toru; Ono, Takashi; Ogihara, Satoshi; Chikuda, Hirotaka; Shoda, Naoki; Nakao, Yusuke; Matsudaira, Ko; Seichi, Atsushi; Nakamura, Kozo

    2010-05-01

    Parameters of the position of the aorta in previous reports were determined for anterior surgery. This study evaluated the relative position of the aorta to the spine by new parameters, which could enhance the safety of pedicle screw placement. Three parameters were defined in a new Cartesian coordinate system. We selected an entry point of a left pedicle screw as the origin. The transverse plane was determined to include both the bases of the superior facet and to be parallel to the upper endplate of the vertebral body. A line connecting the entry points of both sides was defined as the X-axis. The angle formed by the Y-axis and a line connecting the origin and the center of the aorta was defined as the left pedicle-aorta angle. The length of a line connecting the origin and the aorta edge was defined as the left pedicle-aorta distance. Distance from the edge of the aorta to the X-axis was defined as the pedicular line-aorta distance. These parameters were measured preoperatively in 293 vertebral bodies of 24 patients with a right thoracic curve. We simulated the placement of the pedicle screw with variable length and with some direction error. We defined a warning pedicle as that when the aorta enters the expected area of the screw. Sensitivity analysis was performed to find the warning pedicle ratio in 12 scenarios. The left pedicle-aorta angle averaged 29.7 degrees at the thoracic spine and -16.3 degrees at the lumbar spine; the left pedicle-aorta distance averaged 23.7 and 55.2 mm; the pedicular line-aorta distance averaged 18.3 and 51.0 mm, respectively. The ratio of warning pedicles was consistently high at T4-5 and T10-12. When a left pedicle screw perforates an anterior/lateral wall of the vertebral body, the aorta may be at risk. These new parameters enable surgeons to intuitively understand the position of the aorta in surgical planning or in placement of a pedicle screw.

  12. Alteraciones de la aorta ascendente en un modelo animal espontáneo de válvula aórtica bicúspide

    OpenAIRE

    Fernández, Borja; López-García, Alejandro; Fernández, María Carmen; Ramírez-Aragón, Antonio; Márquez-Molina, José Manuel; Sans-Coma, Valentín; Durán, Ana Carmen

    2014-01-01

    La válvula aórtica bicúspide (VAB) es la malformación cardiaca congénita más prevalente y se asocia frecuentemente con dilatación de la aorta ascendente (DAA). Existen dos hipótesis etiológicas sobre esta asociación: 1) genética: VAB y alteraciones estructurales de la pared aórtica son el resultado de un mismo defecto embrionario; 2) hemodinámica: alteraciones del flujo causadas por el defecto valvular provocan la aortopatía. El sustrato histopatológico de la DAA es la necrosis cística ...

  13. Protective effect of soybeans as protein source in the diet against cadmium-aorta redox and morphological alteration

    Energy Technology Data Exchange (ETDEWEB)

    Pérez Díaz, Matías F.F.; Acosta, Mariano; Mohamed, Fabián H.; Ferramola, Mariana L.; Oliveros, Liliana B.; Gimenez, María S., E-mail: marisofigime44@gmail.com

    2013-11-01

    We investigated the effects of cadmium exposition on thoracic aorta redox status and morphology, and the putative protective effect of soybeans in the diet. Male Wistar rats were separated into 6 groups: 3 fed with a diet containing casein and 3 containing soybeans, as protein source. Within each protein group, one was given tap water (control) and the other two tap water containing 15 and 100 ppm of Cd{sup 2+}, respectively, for two months. In rats fed with casein diet, 15 ppm of Cd induced an increase of thiobarbituric acid-reactive substances (TBARS), and of the catalase (CAT) and glutathione peroxidase (GPx) activities, which were even higher with 100 ppm of Cd{sup 2+}, in aorta. Also, 100 ppm Cd{sup 2+} exposure increased superoxide dismutase (CuZnSOD) activity; CAT, GPX, SOD, Nrf2 and metallothioneine II mRNA expressions and CAT, GPx and NOX-2 protein levels, compared with control. Aorta endothelial and cytoplasmic alterations were observed. However, with the soybeans diet, 15 and 100 ppm of Cd{sup 2+} did not modify TBARS levels; CAT, GPX and Nrf2 mRNA expressions; CAT, GPx and NOX-2 protein; and the aorta morphology, compared with control. The soybean diet attenuates the redox changes and protects against morphological alterations induced, in a dose-dependent way, by Cd in aorta. - Highlights: • Under casein diet, 100 ppm Cd{sup 2+} in drinking water induces oxidative stress in aorta. • Under casein diet, 100 ppm Cd{sup 2+} increases Nrf2, MT II and NOX2 expressions in aorta. • Under casein diet, 100 ppm Cd{sup 2+} induces morphological changes in rat aorta. • The soybean diet attenuates the redox changes induced by Cd in rat aorta. • The soybean diet attenuates morphological alterations induced by Cd in rat aorta.

  14. Evaluación de un método manual para producir plasma rico en plaquetas-puro (P-PRP en conejos: estudio hematológico

    Directory of Open Access Journals (Sweden)

    JC González

    2013-01-01

    Full Text Available El objetivo de este estudio fue evaluar un método manual para producir dos clases de plasma rico en plaquetas-puro (P-PRP-A y P-PRP-B en conejos. Ambos P-P-PRP se obtuvieron por extracción de sangre de la vena yugular en tubos con citrato de sodio como anticoagulante y centrifugados a 259 g durante 6 minutos. El número de plaquetas concentradas en la fracción P-PRP-A fue de 716,14 X 10³/μL y 630 X 10³/μL para la fracción P-PRP-B. Para los conteos celulares entre sangre entera y las fracciones P-PRP-A y P-PRP-B, se encontraron diferencias estadísticamente significativas (P < 0,05 entre los recuentos de RBC (10(6/μL, WBC (10³/μL, PLT (10³/μL y PDW (% pero no para MPV (fL. Se encontraron diferencias entre sexos para RBC (10(6/μL, que fue mayor en machos, y el MPV (fL (mayor en hembras para la fracción P-PRP-A. En La fracción P-PRP-B se encontró diferencia para MPV (fL (mayor en hembras. El PDW (% fue mayor en los machos respecto al hemograma. La eficiencia de colección de plaquetas para la fracción P-PRP-A fue de 20,76% y para la fracción P-PRP-B de 18,27%. La concentración de plaquetas respecto a la sangre entera fue de 186,92% para la fracción P-PRP-A y de 164,44% para la fracción P-PRP-B. El protocolo descrito en este estudio representa un método sencillo para obtener P-PRP en conejos con finalidades experimentales e incluso, terapéuticas.

  15. Osteointegración del aloinjerto crioconservado asociado a plasma enriquecido en plaquetas, en defectos óseos infectados. Estudio experimental. [Osseointegration of cryopreserved allograft associated with platelet-rich plasma, in infected bone defects. Experimental study.

    Directory of Open Access Journals (Sweden)

    Pablo Alexis Bruno

    2013-08-01

    Full Text Available Introducción El objetivo de este trabajo experimental es determinar si el agregado de plasma rico en plaquetas influye en la osteointegración del aloinjerto crioconservado con antibióticos, en fracturas infectadas, con pérdida ósea, en huesos largos de conejos. Material y métodos Se evaluaron cuatro grupos de 7 conejos cada uno, a los cuales se les generó una fractura infectada del fémur derecho. En los cuatro grupos, se colocó aloinjerto molido con antibiótico local, en el grupo II y en el grupo IV, se agregó también plasma rico en plaquetas. Se sacrificó a los grupos I y II, a los 30 días, y a los grupos III y IV, a los 90 días. Se realizó una evaluación histológica y tomográfica. Resultados Nueve conejos murieron en el período de estudio. No hubo diferencias estadísticamente significativas entre los grupos evaluados. En el grupo IV, con plasma rico en plaquetas, se observó neoformación ósea en tres de las cuatro muestras; se advirtieron sectores de acoplamiento entre el tejido receptor y el injertado, con consolidación en las imágenes tomográficas. Conclusiones En este trabajo, hubo correlación entre los resultados histológicos y tomográficos. Pese a que no se hallaron diferencias estadísticamente significativas, el agregado de plasma rico en plaquetas, además de estimular la generación de nuevos tejidos, disminuyó la reabsorción del tejido injertado al análisis anatomopatológico, y mostró mayor neoformación ósea y consolidación en el grupo IV (75% tratado con plasma rico en plaque- tas que en el grupo III (25% al que no se asoció plasma rico en plaquetas al aloinjerto óseo.

  16. Aneurisma de la aorta abdominal: Tratamiento endovascular con una endoprótesis fenestrada Abdominal aortic aneurysm: Endovascular treatment with fenestrated endoprothesis

    Directory of Open Access Journals (Sweden)

    Román Rostagno

    2008-12-01

    Full Text Available El tratamiento endovascular de los aneurismas de aorta abdominal es una alternativa a la cirugía abierta para pacientes de alto riesgo. Consiste en la exclusión del saco aneurismático mediante la interposición de una endoprótesis colocada por vía femoral. El tratamiento endovascular no puede ser utilizado en todos los pacientes. Una limitación frecuente la constituye el nacimiento de una arteria visceral desde el saco aneurismático. Para contrarrestar esta limitación recientemente se han desarrollado endoprótesis fenestradas que presentan orificios que se corresponden con el nacimiento de las arterias involucradas en el aneurisma evitando su oclusión, permitiendo de esta manera el tratamiento endovascular. En esta comunicación se presenta un caso de tratamiento endovascular de un aneurisma de aorta abdominal mediante la colocación de una endoprótesis fenestrada en un paciente cuya arteria renal izquierda nacía directamente del saco aneurismático.Endovascular treatment of the abdominal aortic aneurysm is consider an alternative to open surgery for high risk patients. Its goal is to exclude the aneurysm from the circulation by using an endoprothesis introduced from a femoral approach. Patients must be strictly selected to avoid possible complications. The most frequent limitation is related to anatomic contraindications such as visceral arteries involved in the aneurysm. Fenestrated endograft have been recently developed to allow endovascular treatment when anatomic features contraindicate classic endovascular procedures. Fenestrated endograft have holes that match with the origin of the visceral arteries maintaining its potency. In this paper we report the endovascular treatment of an abdominal aortic aneurysm by using a fenestrated endoprothesis in a patient whose left renal artery is originated from the aneurysm.

  17. Relationship between aneurism of ascending part of aorta and syndrome of connective tissue dysplasia

    Directory of Open Access Journals (Sweden)

    Osovska N.Yu.

    2014-11-01

    Full Text Available The paper identifies the main reasons for the development of an aneurysm of the ascending aorta and predictors of its complications in patients of all ages. To determine the cause and age-associated risk factors for aneurysms there were examined 154 patients with the presence of the expansion of the root and / or ascending aorta of more than 40 mm, according to echocardiographic examination. Patients were divided into 4 categories by age: 18-29 years, 30-44 years 45-59 years 60-74 years. Instrumental methods of examination: echocardiography, ECG, ECG monitoring and blood pressure, heart rate variability, ultrasound of internal organs were used. Syndrome of connective tissue dysplasia was established according to the criteria of the working group of the British Society of Rheumatology. Joint hypermobility syndrome was determined according to the Brayton criteria. Statistical processing was carried out by methods of variation statistic program StatSoft "Statistica" v.10.0. It was established that in young and middle aged patients the cause of aneurysm of ascending aorta more often is connective tissue dysplasia syndrome. In older patients the main cause of aneurysm of ascending aorta is associated with left ventricular hypertrophy and decreased contractile function of the heart.

  18. Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model.

    Science.gov (United States)

    Hitchcock, Kathryn E; Caudell, Danielle N; Sutton, Jonathan T; Klegerman, Melvin E; Vela, Deborah; Pyne-Geithman, Gail J; Abruzzo, Todd; Cyr, Peppar E P; Geng, Yong-Jian; McPherson, David D; Holland, Christy K

    2010-06-15

    The goal of this study was to determine whether targeted, Rhodamine-labeled echogenic liposomes (Rh-ELIP) containing nanobubbles could be delivered to the arterial wall, and whether 1-MHz continuous wave ultrasound would enhance this delivery profile. Aortae excised from apolipoprotein-E-deficient (n=8) and wild-type (n=8) mice were mounted in a pulsatile flow system through which Rh-ELIP were delivered in a stream of bovine serum albumin. Half the aortae from each group were treated with 1-MHz continuous wave ultrasound at 0.49 MPa peak-to-peak pressure, and half underwent sham exposure. Ultrasound parameters were chosen to promote stable cavitation and avoid inertial cavitation. A broadband hydrophone was used to monitor cavitation activity. After treatment, aortic sections were prepared for histology and analyzed by an individual blinded to treatment conditions. Delivery of Rh-ELIP to the vascular endothelium was observed, and sub-endothelial penetration of Rh-ELIP was present in five of five ultrasound-treated aortae and was absent in those not exposed to ultrasound. However, the degree of penetration in the ultrasound-exposed aortae was variable. There was no evidence of ultrasound-mediated tissue damage in any specimen. Ultrasound-enhanced delivery within the arterial wall was demonstrated in this novel model, which allows quantitative evaluation of therapeutic delivery.

  19. Unexpected death caused by rupture of a dilated aorta in an adult male with aortic coarctation

    DEFF Research Database (Denmark)

    Leth, Peter Mygind; Knudsen, Peter Juel Thiis

    2015-01-01

    Aortic coarctation (AC) is a congenital aortic narrowing. We describe for the first time the findings obtained by unenhanced post mortem computed tomography (PMCT) in a case where the death was caused by cardiac tamponade from a ruptured aneurysmal dilatation of the ascending aorta and the aortic...

  20. Stress Alone or associated with Ethanol Induces Prostanoid Release in Rat Aorta via α2-Adrenoceptor

    Energy Technology Data Exchange (ETDEWEB)

    Baptista, Rafaela de Fátima Ferreira [Departamento de Farmacologia - Instituto de Biociências - Universidade Estadual Paulista - UNESP - São Paulo, SP (Brazil); Laboratório de Farmacologia - Faculdade de Medicina de Marília - FAMEMA, SP (Brazil); Taipeiro, Elane de Fátima [Laboratório de Farmacologia - Faculdade de Medicina de Marília - FAMEMA, SP (Brazil); Queiroz, Regina Helena Costa [Departamento de Análise Clínica - Toxicológica e Ciência de Alimentos - Faculdade de Ciências Farmacêuticas - USP, São Paulo, SP (Brazil); Chies, Agnaldo Bruno [Departamento de Farmacologia - Instituto de Biociências - Universidade Estadual Paulista - UNESP - São Paulo, SP (Brazil); Laboratório de Farmacologia - Faculdade de Medicina de Marília - FAMEMA, SP (Brazil); Cordellini, Sandra, E-mail: cordelli@ibb.unesp.br [Departamento de Farmacologia - Instituto de Biociências - Universidade Estadual Paulista - UNESP - São Paulo, SP (Brazil)

    2014-03-15

    Stress and ethanol are both, independently, important cardiovascular risk factors. To evaluate the cardiovascular risk of ethanol consumption and stress exposure, isolated and in association, in male adult rats. Rats were separated into 4 groups: Control, ethanol (20% in drinking water for 6 weeks), stress (immobilization 1h day/5 days a week for 6 weeks) and stress/ethanol. Concentration-responses curves to noradrenaline - in the absence and presence of yohimbine, L-NAME or indomethacin - or to phenylephrine were determined in thoracic aortas with and without endothelium. EC50 and maximum response (n=8-12) were compared using two-way ANOVA/Bonferroni method. Either stress or stress in association with ethanol consumption increased the noradrenaline maximum responses in intact aortas. This hyper-reactivity was eliminated by endothelium removal or by the presence of either indomethacin or yohimbine, but was not altered by the presence of L-NAME. Meanwhile, ethanol consumption did not alter the reactivity to noradrenaline. The phenylephrine responses in aortas both with and without endothelium also remained unaffected regardless of protocol. Chronic stress increased rat aortic responses to noradrenaline. This effect is dependent upon the vascular endothelium and involves the release of vasoconstrictor prostanoids via stimulation of endothelial alpha-2 adrenoceptors. Moreover, chronic ethanol consumption appeared to neither influence noradrenaline responses in rat thoracic aorta, nor did it modify the increase of such responses observed as a consequence of stress exposure.

  1. Feasibility of low contrast media volume in CT angiography of the aorta

    NARCIS (Netherlands)

    Seehofnerová, Anna; Kok, Madeleine; Mihl, Casper; Douwes, Dave; Sailer, Anni; Nijssen, Estelle; de Haan, Michiel J W; Wildberger, Joachim E; Das, Marco

    2015-01-01

    OBJECTIVES: Using smaller volumes of contrast media (CM) in CT angiography (CTA) is desirable in terms of cost reduction and prevention of contrast-induced nephropathy (CIN). The purpose was to evaluate the feasibility of low CM volume in CTA of the aorta. METHODS: 77 patients referred for CTA of th

  2. Imaging of the distal ascending aorta using modified transesophageal echocardiography in cardiac surgery

    NARCIS (Netherlands)

    van Zaane, B.

    2009-01-01

    Epiaortic ultrasound scanning of the ascending aorta is a safe and useful method to detect atherosclerosis in patients undergoing cardiac surgery. The use of epiaortic ultrasound can lead to modifications of the surgical technique, which effectively reduces the post-operative incidence of stroke in

  3. Medical image of the week: atherosclerotic aneurysm of aortic arch and descecnding thoracic aorta

    Directory of Open Access Journals (Sweden)

    Parasram M

    2016-02-01

    Full Text Available No abstract available. Article truncated after 150 words. A 94-year-old Spanish-speaking woman presented to the hospital with intermittent episodes of dyspnea and abdominal pain for one week. Her past medical history was notable for 30 pack-year smoking history and hypertension, which was reportedly controlled with medical therapy. Physical exam showed trace peripheral edema bilaterally, intact peripheral pulses, and a mild abdominal bruit. Work up at the emergency department revealed a non-ST elevation myocardial infarction with troponin T of 0.34 ng/mL but no ST-wave abnormality on electrocardiography. Chest x-ray displayed an incidental thoracic aneurysm (Figure 1. Chest computed tomography with contrast demonstrated a continuous aneurysm of the aortic arch and descending thoracic aorta with diameters measuring 6.8 cm and 6 cm, respectively (Figure 2A and 2B. Eccentric thrombi are noted in the aortic arch and the descending aorta. Interestingly, the distal descending thoracic aorta curves as it transitions to the abdominal aorta, which is evidence of a tortuous descending ...

  4. The influence of the aortic valve angle on the hemodynamic features of the thoracic aorta

    Science.gov (United States)

    Ha, Hojin; Kim, Guk Bae; Kweon, Jihoon; Lee, Sang Joon; Kim, Young-Hak; Kim, Namkug; Yang, Dong Hyun

    2016-08-01

    Since the first observation of a helical flow pattern in aortic blood flow, the existence of helical blood flow has been found to be associated with various pathological conditions such as bicuspid aortic valve, aortic stenosis, and aortic dilatation. However, an understanding of the development of helical blood flow and its clinical implications are still lacking. In our present study, we hypothesized that the direction and angle of aortic inflow can influence helical flow patterns and related hemodynamic features in the thoracic aorta. Therefore, we investigated the hemodynamic features in the thoracic aorta and various aortic inflow angles using patient-specific vascular phantoms that were generated using a 3D printer and time-resolved, 3D, phase-contrast magnetic resonance imaging (PC-MRI). The results show that the rotational direction and strength of helical blood flow in the thoracic aorta largely vary according to the inflow direction of the aorta, and a higher helical velocity results in higher wall shear stress distributions. In addition, right-handed rotational flow conditions with higher rotational velocities imply a larger total kinetic energy than left-handed rotational flow conditions with lower rotational velocities.

  5. Giant Aneursym of the Ascending Aorta 37 Years after Aortic Valve Replacement

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    Fabrizio Sansone

    2013-04-01

    Full Text Available Giant ascending aorta aneurysms (AAA, which are larger than 10 cm, are rare. We hereby present the case of a giant AAA of about 13 cm, incidentally detected several years after aortic valve replacement and treated according to the Cabrol technique without postoperative complications. [Arch Clin Exp Surg 2013; 2(2.000: 129-131

  6. TAVR Through Heavily Calcified Aorta Following Atheroma Retrieval With the "Elevator" Technique.

    Science.gov (United States)

    Senguttuvan, N Boopathy; Ellozy, Sharif; Tejani, Furqan; Kovacic, Jason; Kini, Annapoorna S; Sharma, Samin K; Dangas, George D

    2015-10-01

    An 86-year-old Caucasian female with severe symptomatic, inoperable aortic stenosis was accepted for high-risk transfemoral transcatheter aortic valve replacement (TAVR) approach due to severe calcification of the aorta. During initial passage of a 22 Fr sheath, there was dislodgment with proximal migration of a circumferential tunnel of calcium from the infrarenal aorta. A novel "elevator" technique was used to secure and retrieve the dislodged aorta en bloc back to its original infrarenal aortic position and allow in situ fixation with stenting. A new TAVR system was then successfully placed through the stent and a 23 mm Edwards Sapien valve (Edwards Lifesciences) was implanted as planned. In case of calcification protruding into the lumen of the aorta and limiting the passage of the large valve delivery system sheath, the obstruction can be managed by stenting the calcification against the luminal wall under fluoroscopic and intravascular-ultrasound guidance, allowing successful passage of the valve delivery system. The elevator technique allows axial transportation of any calcified vascular fragments, should they become dislodged.

  7. Blood flow characteristics in the ascending aorta after TAVI compared to surgical aortic valve replacement.

    Science.gov (United States)

    Trauzeddel, Ralf Felix; Löbe, Ulrike; Barker, Alex J; Gelsinger, Carmen; Butter, Christian; Markl, Michael; Schulz-Menger, Jeanette; von Knobelsdorff-Brenkenhoff, Florian

    2016-03-01

    Ascending aortic blood flow characteristics are altered after aortic valve surgery, but the effect of transcatheter aortic valve implantation (TAVI) is unknown. Abnormal flow may be associated with aortic and cardiac remodeling. We analyzed blood flow characteristics in the ascending aorta after TAVI in comparison to conventional stented aortic bioprostheses (AVR) and healthy subjects using time-resolved three-dimensional flow-sensitive cardiovascular magnetic resonance imaging (4D-flow MRI). Seventeen patients with TAVI (Edwards Sapien XT), 12 with AVR and 9 healthy controls underwent 4D-flow MRI of the ascending aorta. Target parameters were: severity of vortical and helical flow pattern (semiquantitative grading from 0 = none to 3 = severe) and the local distribution of systolic wall shear stress (WSSsystole). AVR revealed significantly more extensive vortical and helical flow pattern than TAVI (p = 0.042 and p = 0.002) and controls (p flow than controls (p blood flow eccentricity (64.7 and 66.7%, respectively), whereas controls showed central blood flow (88.9%). TAVI and AVR exhibited an asymmetric distribution of WSSsystole in the mid-ascending aorta with local maxima at the right anterior aortic wall and local minima at the left posterior wall. In contrast, controls showed a symmetric distribution of WSSsystole along the aortic circumference. Blood flow was significantly altered in the ascending aorta after TAVI and AVR. Changes were similar regarding WSSsystole distribution, while TAVI resulted in less helical and vortical blood flow.

  8. Atherosclerosis of the descending aorta predicts cardiovascular events: a transesophageal echocardiography study

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    Havasi Kálmán

    2004-10-01

    Full Text Available Abstract Purpose Previous studies have shown that atherosclerosis of the descending aorta detected by transesophageal echocardiography (TEE is a good marker of coexisting coronary artery disease. The aim of our study was to evaluate whether the presence of atherosclerosis on the descending aorta during TEE has any prognostic impact in predicting cardiovascular events. Material and Methods The study group consisted of 238 consecutive in-hospital patients referred for TEE testing (135 males, 103 females, mean age 58 +/- 11 years with a follow up of 24 months. The atherosclerotic lesions of the descending aorta were scored from 0 (no atherosclerosis to 3 (plaque >5 mm and/or "complex" plaque with ulcerated or mobile parts. Results Atherosclerosis was observed in 102 patients, (grade 3 in 16, and grade 2 in 86 patients whereas 136 patients only had an intimal thickening or normal intimal surface. There were 57 cardiovascular events in the follow-up period. The number of events was higher in the 102 patients with (n = 34 than in the 136 patients without atherosclerosis (n = 23, p =2 (HR 2.4, CI 1.0–5.5 predicted hard cardiovascular events. Conclusion Atherosclerosis of the descending aorta observed during transesophageal echocardiography is a useful predictor of cardiovascular events.

  9. Acute intramural hematoma of ascending aorta. CT findings and clinical outcome

    Energy Technology Data Exchange (ETDEWEB)

    Yamaguchi, Toshio; Sakuyama, Keiko; Hiekata, Tomizou; Yamanaka, Ikuo [St. Marianna Univ., Kanagawa (Japan). Yokohama Seibu Hospital; Kuroki, Kazunori; Ohyama, Yukio; Ishikawa, Tohru; Kawada, Tadanori; Akashi, Katsuya

    1997-12-01

    The purpose of this study was to describe the CT findings and clinical outcomes of nineteen patients with acute intramural hematoma (IMH) of the ascending aorta. Six patients underwent surgery on the emergency basis (3 patients) due to cardiac tamponade (n=2) and dilated aorta (n=1), and on the elective basis (3 patients) due to patent and enlarging false lumen. Among the 13 patients with medical management, four patients died from complications of IMH during the follow-up period (2 days-2.5 years). Transition to aortic dissection or enlargement of an intimal tear was noted in 5 patients (31%) in 1 to 6 weeks after onset. Three patients died of causes not related to IMH. Six patients had been alive 2 to 9 years after onset. Retrospective review revealed 10 patients (53%) as possible surgical candidates, and the other 9 patients as medically treated patients in the long-term follow-up. The surgical group showed cardiac tamponade or shock in 6 patients on admission and had pericardial effusion in all the patients on the initial CT scan. In the patients with acute IMH of the ascending aorta, surgery should be considered for severe clinical symptoms, pericardial effusion and large size of the ascending aorta (more than 4 cm) on CT scan, and for converting to a typical type A aortic dissection. CT scan had a major role in making an early diagnosis, in depicting a dangerous sign, and in monitoring its progression or resolution of IMH. (author)

  10. Supersized Atheroma Causing Acquired Coarctation of Aorta Leading to Heart Failure

    Science.gov (United States)

    Karakattu, Sajin; Murtaza, Ghulam; Dinesh, Sharma; Sivagnanam, Kamesh; Schoondyke, Jeffrey; Paul, Timir

    2017-01-01

    Calcified atheromatous aortic lesion causing significant narrowing of the aorta is an uncommon clinical entity. This calcified atheroma leads to obstruction of the lumen of the aorta simulating acquired coarctation of aorta causing impaired perfusion of lower limbs, visceral ischemia, and hypertension. We report a case of 58-year-old patient who presented with dyspnea on exertion, orthopnea, paroxysmal nocturnal dyspnea, 25-lb weight gain, lower extremity edema, and chest pain. Extensive workup including computed tomography and magnetic resonance imaging revealed a large calcific mass in the aortic arch causing his presenting symptoms. After surgical correction his symptoms resolved. Any patient presenting with heart failure symptoms in the setting of uncontrolled renovascular hypertension, intermittent claudication symptoms, or visceral ischemia with normal ejection fraction but moderate to severe left ventricular hypertrophy should be in high suspicion for acquired coarctation of aorta. The routine thorough examination of pulses in bilateral upper and lower extremities in all hypertensive patients is a very simple and useful clinical tool to diagnose acquired aortic coarctation. PMID:28203578

  11. Unexpected death caused by rupture of a dilated aorta in an adult male with aortic coarctation.

    Science.gov (United States)

    Leth, Peter Mygind; Knudsen, Peter Thiis

    2015-09-01

    Aortic coarctation (AC) is a congenital aortic narrowing. We describe for the first time the findings obtained by unenhanced post mortem computed tomography (PMCT) in a case where the death was caused by cardiac tamponade from a ruptured aneurysmal dilatation of the ascending aorta and the aortic arch without dissection combined with aortic coarctation. The patient, a 46-year-old man, was found dead at home. PMCT showed haemopericardium and dilatation of the ascending aorta and the aortic arch. This appearance led to the mistaken interpretation that the images represented a dissecting aneurysm. The autopsy showed instead a thin-walled and floppy dilatation of the ascending aorta and aortic arch with a coarctation just proximal to the ligamentum arteriosum. A longitudinal tear was found in the posterior aortic wall just above the valves. Blood in the surrounding soft tissue intersected with a large haematoma (1000ml) in the pericardial sac. Cardiac hypertrophy (556g) was observed in the patient, though no other cardiovascular abnormalities were found. Histological analysis showed cystic medial necrosis of the ascending aortic wall. A ruptured aneurysmal dilatation of the ascending aorta and the aortic arch without aortic dissection associated with AC is an uncommon cause of haemopericardium that has only been described a few times before. The case is discussed in relation to other reported cases and in the context of the present understanding of this condition.

  12. Coarctatio aortae: 40 års opfølgning efter kirurgisk korrektion - sekundaerpublikation

    DEFF Research Database (Denmark)

    Høimyr, Hilde; Pedersen, Thais A L; Christensen, Thomas D;

    2009-01-01

    Coarctation of the aorta (CoA) was previously considered cured after surgical repair. Among 229 patients operated for CoA in Aarhus between 1965 and 1985, 14 died at surgery and 35 died during 20-40 years of follow-up, mainly due to cardiovascular disease. The mortality among CoA patients was 4...

  13. Modified transesophageal echocardiography of the dissected thoracic aorta; A novel diagnostic approach

    NARCIS (Netherlands)

    Jansen Klomp, Wouter W.; Peelen, Linda M.; Brandon Bravo Bruinsma, George J.; Van'T Hof, Arnoud W J; Grandjean, Jan G.; Nierich, Arno P.

    2016-01-01

    Background: Transesophageal echocardiography (TEE) is a key diagnostic modality in patients with acute aortic dissection, yet its sensitivity is limited by a "blind-spot" caused by air in the trachea. After placement of a fluid-filled balloon in the trachea visualization of the thoracic aorta become

  14. Endovascular management of bilateral superior intercostal artery aneurysms following late repair of coarctation of the aorta.

    Science.gov (United States)

    Tapping, C R; Ettles, D F

    2011-08-01

    Endovascular management of massive bilateral superior intercostal artery aneurysms following late surgical repair of juxtaductal coarctation of the aorta is described in a 40-year-old male patient. Both aneurysms were successfully treated by coil embolisation without the need for further surgical intervention.

  15. Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region

    NARCIS (Netherlands)

    C. Orelio; E.A. Dzierzak (Elaine)

    2003-01-01

    textabstractThe first adult-repopulating hematopoietic stem cells (HSCs) emerge in the mouse aorta-gonad-mesonephros (AGM) region at embryonic day 10.5 prior to their appearance in the yolk sac and fetal liver. Although several genes are implicated in the regulation of HSCs, there

  16. Aortic annulus and ascending aorta: Comparison of preoperative and periooperative measurement in patients with aortic stenosis

    Energy Technology Data Exchange (ETDEWEB)

    Smid, Michal [Cardiology Department of Internal Medicine, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: kosvin@seznam.cz; Ferda, Jiri [Department of Radiology, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: ferda@fnplzen.cz; Baxa, Jan [Department of Radiology, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: baxaj@fnplzen.cz; Cech, Jakub [Cardiology Department of Internal Medicine, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: cechj@fnplzen.cz; Hajek, Tomas [Department of Cardiac Surgery, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: hajekt@fnplzen.cz; Kreuzberg, Boris [Department of Radiology, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: kreuzberg@fnplzen.cz; Rokyta, Richard [Cardiology Department of Internal Medicine, School of Medicine Plzen, Charles University Prague and University Hospital Plzen, alej Svobody 80, 304 60 Plzen (Czech Republic)], E-mail: rokyta@fnplzen.cz

    2010-04-15

    Background: Precise determination of the aortic annulus size constitutes an integral part of the preoperative evaluation prior to aortic valve replacement. It enables the estimation of the size of prosthesis to be implanted. Knowledge of the size of the ascending aorta is required in the preoperative analysis and monitoring of its dilation enables the precise timing of the operation. Our goal was to compare the precision of measurement of the aortic annulus and ascending aorta using magnetic resonance (MR), multidetector-row computed tomography (MDCT), transthoracic echocardiography (TTE), and transoesophageal echocardiography (TEE) in patients with degenerative aortic stenosis. Methods and results: A total of 15 patients scheduled to have aortic valve replacement were enrolled into this prospective study. TTE was performed in all patients and was supplemented with TEE, CT and MR in the majority of patients. The values obtained were compared with perioperative measurements. For the measurement of aortic annulus, MR was found to be the most precise technique, followed by MDCT, TTE, and TEE. For the measurement of ascending aorta, MR again was found to be the most precise technique, followed by MDCT, TEE, and TTE. Conclusion: In our study, magnetic resonance was found to be the most precise technique for the measurement of aortic annulus and ascending aorta in patients with severe degenerative aortic stenosis.

  17. Perforation of a gastric tube peptic ulcer into the thoracic aorta.

    Science.gov (United States)

    Katsoulis, I E; Veloudis, G; Exarchos, D; Yannopoulos, P

    2001-01-01

    We present a case of a 52-year-old male patient who died from massive hematemesis as a result of perforation of a benign peptic ulcer into the descending thoracic aorta, 1 year after esophagectomy for esophageal cancer and gastric tube interposition. We also review the literature for mechanisms of ulceration in intrathoracic gastric grafts and for complications of such ulcers.

  18. The relationship between wall shear stress distributions and intimal thickening in the human abdominal aorta

    Directory of Open Access Journals (Sweden)

    Butany Jagdish

    2003-11-01

    Full Text Available Abstract Purpose The goal of this work was to determine wall shear stress (WSS patterns in the human abdominal aorta and to compare these patterns to measurements of intimal thickness (IT from autopsy samples. Methods The WSS was experimentally measured using the laser photochromic dye tracer technique in an anatomically faithful in vitro model based on CT scans of the abdominal aorta in a healthy 35-year-old subject. IT was quantified as a function of circumferential and axial position using light microscopy in ten human autopsy specimens. Results The histomorphometric analysis suggests that IT increases with age and that the distribution of intimal thickening changes with age. The lowest WSS in the flow model was found on the posterior wall inferior to the inferior mesenteric artery, and coincided with the region of most prominent IT in the autopsy samples. Local geometrical features in the flow model, such as the expansion at the inferior mesenteric artery (common in younger individuals, strongly influenced WSS patterns. The WSS was found to correlate negatively with IT (r2 = 0.3099; P = 0.0047. Conclusion Low WSS in the abdominal aorta is co-localized with IT and may be related to atherogenesis. Also, rates of IT in the abdominal aorta are possibly influenced by age-related geometrical changes.

  19. Mega aorta syndrome: a case of thoracic and abdominal aortic aneurysm.

    Science.gov (United States)

    Wu, William C; Mitchell, Christopher A; Linklater, Derek

    2010-07-01

    An 83-year-old woman presented to the emergency department (ED) via emergency medical services with the chief complaint of "strokelike symptoms." Physical examination revealed altered mental status, tachycardia, hypotension, and a large nonpulsatile periumbilical mass. Bedside ultrasound revealed a 9-cm abdominal aortic aneurysm with absent central flow. Computed tomography scan demonstrated diffuse thoracic and abdominal aortic dilation with rupture into the mediastinum along with left hemothorax. Repeat beside ultrasound demonstrated abdominal aortic aneurysm rupture not seen on the computed tomography scan. Despite aggressive resuscitation, the patient developed bradycardia, which devolved into pulseless electric activity cardiac arrest. She was unable to be resuscitated. The patient's diffuse aneurysmal dilation places her into the small category of patients with a disease entity known as mega aorta syndrome (MAS). Mega aorta syndrome is defined as aneurysmal dilation of the aorta to greater than 6 cm in diameter. Although not in our case, most cases of MAS are symptomatic before catastrophic presentation. The disease progression for these patients is slow and occurs over years. When this disease is recognized early, a surgery known as the elephant trunk procedure can be performed. This operation replaces the entire aorta in multiple stages. This gives the emergency physician a critical role in the diagnosis and outcome of these patients because they may come through the ED for an unrelated complaint early in the disease process. This case report illustrates an advanced case of MAS.

  20. Contribution of collagen fiber undulation to regional biomechanical properties along porcine thoracic aorta.

    Science.gov (United States)

    Zeinali-Davarani, Shahrokh; Wang, Yunjie; Chow, Ming-Jay; Turcotte, Raphaël; Zhang, Yanhang

    2015-05-01

    As major extracellular matrix components, elastin, and collagen play crucial roles in regulating the mechanical properties of the aortic wall and, thus, the normal cardiovascular function. The mechanical properties of aorta, known to vary with age and multitude of diseases as well as the proximity to the heart, have been attributed to the variations in the content and architecture of wall constituents. This study is focused on the role of layer-specific collagen undulation in the variation of mechanical properties along the porcine descending thoracic aorta. Planar biaxial tensile tests are performed to characterize the hyperelastic anisotropic mechanical behavior of tissues dissected from four locations along the thoracic aorta. Multiphoton microscopy is used to image the associated regional microstructure. Exponential-based and recruitment-based constitutive models are used to account for the observed mechanical behavior while considering the aortic wall as a composite of two layers with independent properties. An elevated stiffness is observed in distal regions compared to proximal regions of thoracic aorta, consistent with sharper and earlier collagen recruitment estimated for medial and adventitial layers in the models. Multiphoton images further support our prediction that higher stiffness in distal regions is associated with less undulation in collagen fibers. Recruitment-based models further reveal that regardless of the location, collagen in the media is recruited from the onset of stretching, whereas adventitial collagen starts to engage with a delay. A parameter sensitivity analysis is performed to discriminate between the models in terms of the confidence in the estimated model parameters.

  1. Calcifications of the thoracic aorta on extended non-contrast-enhanced cardiac CT.

    Directory of Open Access Journals (Sweden)

    Damian Craiem

    Full Text Available BACKGROUND: The presence of calcified atherosclerosis in different vascular beds has been associated with a higher risk of mortality. Thoracic aorta calcium (TAC can be assessed from computed tomography (CT scans, originally aimed at coronary artery calcium (CAC assessment. CAC screening improves cardiovascular risk prediction, beyond standard risk assessment, whereas TAC performance remains controversial. However, the curvilinear portion of the thoracic aorta (TA, that includes the aortic arch, is systematically excluded from TAC analysis. We investigated the prevalence and spatial distribution of TAC all along the TA, to see how those segments that remain invisible in standard TA evaluation were affected. METHODS AND RESULTS: A total of 970 patients (77% men underwent extended non-contrast cardiac CT scans including the aortic arch. An automated algorithm was designed to extract the vessel centerline and to estimate the vessel diameter in perpendicular planes. Then, calcifications were quantified using the Agatston score and associated with the corresponding thoracic aorta segment. The aortic arch and the proximal descending aorta, "invisible" in routine CAC screening, appeared as two vulnerable sites concentrating 60% of almost 11000 calcifications. The aortic arch was the most affected segment per cm length. Using the extended measurement method, TAC prevalence doubled from 31% to 64%, meaning that 52% of patients would escape detection with a standard scan. In a stratified analysis for CAC and/or TAC assessment, 111 subjects (46% women were exclusively identified with the enlarged scan. CONCLUSIONS: Calcium screening in the TA revealed that the aortic arch and the proximal descending aorta, hidden in standard TA evaluations, concentrated most of the calcifications. Middle-aged women were more prone to have calcifications in those hidden portions and became candidates for reclassification.

  2. Methylprednisolone stiffens aortas in lipopolysaccharide-induced chronic inflammation in rats.

    Directory of Open Access Journals (Sweden)

    Ya-Hui Ko

    Full Text Available INTRODUCTION: Glucocorticoids are commonly used as therapeutic agents in many acute and chronic inflammatory and auto-immune diseases. The current study investigated the effects of methylprednisolone (a synthetic glucocorticoid on aortic distensibility and vascular resistance in lipopolysaccharide-induced chronic inflammation in male Wistar rats. METHODS: Chronic inflammation was induced by implanting a subcutaneous slow-release ALZET osmotic pump (1 mg kg(-1 day(-1 lipopolysaccharide for either 2 or 4 weeks. Arterial wave transit time (τ was derived to describe the elastic properties of aortas using the impulse response function of the filtered aortic input impedance spectra. RESULTS: Long-term lipopolysaccharide challenge enhanced the expression of advanced glycation end products (AGEs in the aortas. Lipopolysaccharide also upregulated the inducible form of nitric oxide synthase to produce high levels of nitric oxide (NO, which resulted in vasodilation, as evidenced by the fall in total peripheral resistance (Rp . However, lipopolysaccharide challenge did not influence the elastic properties of aortas, as shown by the unaltered τ. The NO-mediated vascular relaxation may counterbalance the AGEs-induced arterial stiffening so that the aortic distensibility remained unaltered. Treating lipopolysaccharide-challenged rats with methylprednisolone prevented peripheral vasodilation because of its ability to increase Rp . However, methylprednisolone produced an increase in aorta stiffness, as manifested by the significant decline in τ. The diminished aortic distensibility by methylprednisolone paralleled a significant reduction in NO plasma levels, in the absence of any significant changes in AGEs content. CONCLUSION: Methylprednisolone stiffens aortas and elastic arteries in lipopolysaccharide-induced chronic inflammation in rats, for NO activity may be dominant as a counteraction of AGEs.

  3. Hybrid Endovascular Aorta Repair with Simultaneous Supra-aortic Branch or Iliac Branch Revascularization

    Institute of Scientific and Technical Information of China (English)

    Yue-hong Zheng; Nim Choi; Hong-ru Deng; CU Kouk; Kun Yu; Furtado Rui

    2009-01-01

    Objective To describe a hybrid endovascular procedure for aorta repair with different kinds of bypass followed by concomitant placement of stent graft in the aorta.Methods From June 2007 to May 2008,5 consecutive patients who presented with aortic aneurysm or dissection were treated with a new hybrid aorta repair technique.Complete surgical rerouting of supra-aortic vessels was simultaneously created by endovascular repair of aortic arch aneurysm with stent graft.Hybrid left carotid-subclavian bypass with stent graft deployment covering the ostium of the left subclavian artery was performed in a Debakey type Ⅲ aortic dissection case.The supra-aortic branch was revascularized in 2 cases from ascending aorta to bilateral common carotid arteries using a 16-8 mm bifurcated graft,then total aortic arch and descending artery was occluded with stent-graft.The left carotid artery to the left subclavian artery bypass was created in 1 case,followed by stent-graft deployment.Two cases of infrarenal abdominal aortic aneurysm underwent left external iliac artery to left internal iliac artery bypass by a retroperineal route,then hybrid procedure was performed with bifurcated stent-graft.All stent grafts were deployed via a retrograde femoral artery approach in 5 patients.Results Technical success with complete aneurysmal exclusion was achieved in all patients.There was no incidence of endoleak.During a follow-up period of 2 to 10 months,documented perioperative neurologic events did not occur in all patients.One patient suffered from adult respiratory distress syndrome.After received tracheostomy,he recovered later.There was one death resulting from a postoperative myocardial infarction.Conclusion Hybrid arch repair provides an alternative therapy to patients otherwise considered prohibitively high risk for traditional open arch and thoracoabdominal aorta repair.

  4. Automatic aorta segmentation and valve landmark detection in C-arm CT: application to aortic valve implantation.

    Science.gov (United States)

    Zheng, Yefeng; John, Matthias; Liao, Rui; Boese, Jan; Kirschstein, Uwe; Georgescu, Bogdan; Zhou, S Kevin; Kempfert, Jörg; Walther, Thomas; Brockmann, Gernot; Comaniciu, Dorin

    2010-01-01

    C-arm CT is an emerging imaging technique in transcatheter aortic valve implantation (TAVI) surgery. Automatic aorta segmentation and valve landmark detection in a C-arm CT volume has important applications in TAVI by providing valuable 3D measurements for surgery planning. Overlaying 3D segmentation onto 2D real time fluoroscopic images also provides critical visual guidance during the surgery. In this paper, we present a part-based aorta segmentation approach, which can handle aorta structure variation in case that the aortic arch and descending aorta are missing in the volume. The whole aorta model is split into four parts: aortic root, ascending aorta, aortic arch, and descending aorta. Discriminative learning is applied to train a detector for each part separately to exploit the rich domain knowledge embedded in an expert-annotated dataset. Eight important aortic valve landmarks (three aortic hinge points, three commissure points, and two coronary ostia) are also detected automatically in our system. Under the guidance of the detected landmarks, the physicians can deploy the prosthetic valve properly. Our approach is robust under variations of contrast agent. Taking about 1.4 seconds to process one volume, it is also computationally efficient.

  5. Non-visualized aorta in abdominal aortic aneurysm screening: Screening outcomes and the influence of subject and programme characteristics.

    Science.gov (United States)

    Bennett, Damien; Stewart, Diane; Kearns, Deirdre; Mairs, Adrian; Ellis, Peter

    2017-01-01

    Objectives To compare abdominal aortic aneurysm screening outcomes of men with non-visualized aorta at original scan with subsequent scans and to determine predictors of non-visualized aorta. Methods In the Northern Ireland Abdominal Aortic Aneurysm screening programme, outcomes (discharge, annual surveillance, three-monthly surveillance, or vascular referral) and patient and programme characteristics (age, deprivation quintile, family history, technician experience, and screening location) for men with non-visualized aorta were investigated at original scan, and first and second rescans. Results Non-visualized aorta proportions were 2.9, 11.4, and 4.7% at original, first, and second rescan, respectively. There were no differences in screening outcomes between scanning stages (98.4, 97.6, and 97.4% abdominal aortic aneurysm in men with non-visualized aorta on first or subsequent rescans is no more than for those with visualized aorta on original scanning. Men from deprived areas are much more likely to have non-visualized aorta at original scan.

  6. Expression of p-PPARγ in the aging thoracic aorta of spontaneously hypertensive rat and inhibitory effect of rosiglitazone

    Institute of Scientific and Technical Information of China (English)

    Hai-FengYuan; Xiao-Lin Niu; Deng-Feng Gao; Guang-Hua Hao; An-Qi Song; Jin Wei

    2014-01-01

    To investigate the expression of phosphorylated peroxisome proliferators-activated receptor γ (p-PPARγ) in the aging thoracic aorta of spontaneously hypertensive rat (SHR) and the inhibitory effect of rosiglitazone on the phosphorylation of PPARγ. Methods: 16, 32 and 64 week-old Wistar-Kyoto rats (WKY) and SHR were randomly and respectively divided into WKY, SHR and SHR+rosiglitazone group (9 in each group). The rats in SHR+rosiglitazone group were treated with rosiglitazone (5 mg/kg, intragastrically) for 56 d, whereas normal saline was applied in WKY and SHR groups. Systolic blood pressure (SBP) of rats was measured by tail cuff method. Histopathological damage of thoracic aorta was analyzed using Hematoxylin-Eosin (HE) staining. Immunohistochemical staining and western blot were performed to test the level of p-PPARγ protein in the thoracic aorta arising from each group. Results: The SBP in 16, 32 and 64 week-old SHR were significantly higher as compared with those in matched WKY rats (P<0.05, respectively). HE staining showed increased content of smooth muscle cell, wrinkled lining endothelium and increased thickness of internal elastic lamina in the thoracic aorta of SHR. Immunohistochemical staining and western blot indicated that the levels of p-PPARγ in the thoracic aorta arising from SHR were obviously higher than those in the thoracic aorta arising from WKY rats (P<0.05, respectively). Importantly, the high SBP, histopathological abnormalities of the thoracic aorta and elevated p-PPARγ expression were prominently abrogated by rosiglitazone treatment in SHR (P<0.05, respectively). Furthermore, the SBP, histopathological abnormalities of the thoracic aorta and p-PPARγexpression were positively correlated with age in SHR (P<0.05, respectively). Conclusions: The PPARγ phosphorylation was observed in the thoracic aorta of SHR and its expression was increased by the increase of age. Furthermore, rosiglitazone inhibited the PPARγ phosphorylation and

  7. Ultra-sonografia da aorta abdominal e de seus ramos em cães Ultrasonography of abdominal aorta and its branches in dogs

    Directory of Open Access Journals (Sweden)

    Lilian Kamikawa

    2007-04-01

    Full Text Available O ultra-som bidimensional e o ultra-som Doppler foram utilizados para avaliar a biometria e a hemodinâmica da aorta abdominal e artérias ilíacas externas de 131cães clinicamente normais. Os resultados da avaliação biométrica da aorta abdominal indicaram um diâmetro médio de 0,80cm para o seu segmento diafragmático (AOD; 0,74cm para o seu segmento caudal às artérias renais (AOR e 0,69cm para o segmento cranial à sua bifurcação (AOT. A artéria ilíaca externa direita (AIED apresentou o diâmetro médio de 0,42cm e a artéria ilíaca externa esquerda (AIEE o diâmetro médio de 0,39. O estudo hemodinâmico da aorta abdominal apresentou velocidade de pico sistólico médio de 104,00cm/s para AOR; 99,61cm/s para AOT; 85,47cm/s para AIED e 99,51cm/s para AIEE. Verificaram-se correlações de diferentes intensidades entre os diâmetros vasculares em diferentes pontos de tomadas e os fatores biométricos corpóreos (CRL. Correlações baixas foram observadas quando esses diâmetros foram confrontados com a idade.A duplex ultrasound system incorporating a pulsed wave Doppler ultrasound probe with conventional B-mode real-time imaging was used to evaluate the biometric and the hemodynamic of abdominal aorta and external iliac arteries of a hundred and thirty one normal dogs. Results of biometrics of abdominal aorta, presented a mean diameter of 0.80cm in its diaphragmatic segment (AOD; 0.74cm in its segment caudal to the renal arteries (AOR and 0.69cm in the segment cranial to its termination (AOT. The right-external-iliac artery (AIED presented a mean diameter of 0.42cm and the left-external iliac artery (AIEE a mean diameter of 0.39cm. The hemodynamic study of the abdominal aorta presented a medium systolic peak velocity to AOR of 104cm per sec.; to AOT of 99.61cm per sec.; to AIED of 85.47cm per sec. and to AIEE of 99.51cm per sec. Correlations of different intensities between the vascular diameters have been verified between the

  8. Reconstrução da aorta com conduto de pericárdio bovino corrugado

    Directory of Open Access Journals (Sweden)

    Claudio A. Salles

    1998-04-01

    Full Text Available No período de outubro de 1989 a maio de 1997, 40 pacientes portadores de dissecção aórtica, aneurisma da aorta, coarctação da aorta ou doença oclusiva aorto-ilíaca foram submetidos a reconstrução da aorta utilizando-se conduto de pericárdio bovino corrugado processado em glutaraldeído. A reconstrução total da aorta ascendente com substituição da valva aórtica e reimplante das artérias coronárias foi realizada em 9 pacientes, a simples substituição da aorta ascendente em 6, aorta torácica descendente em 2, arco aórtico em 1, aorta toracoabdominal em 1 e a aorta abdominal foi reconstruída em 21, incluindo pacientes submetidos a reconstrução aorto-ilíaca ou aorto-femoral. A mortalidade hospitalar foi de 8 (20% pacientes e as causas de óbito foram baixo débito cardíaco, recidiva da dissecção aórtica, falência de múltiplos órgãos e sangramento. O seguimento total foi de 128,4 pacientes-anos, com um seguimento médio de 4 anos por paciente. Complicações tardias relacionadas ao conduto vascular foram observadas em 4 pacientes, incluindo obstrução de um dos ramos do tubo bifurcado utilizado para reconstrução aorto-femoral e infecção em 3, resultando em degeneração secundária do conduto e formação de pseudo-aneurisma. Os 4 pacientes foram submetidos a reoperações, correspondendo a uma incidência de 3,1% ± 1,6% por paciente/ano. Ocorreram 5 óbitos tardios e as causas foram morte súbita, doença coronariana, pneumonia, septicemia e complicações metabólicas resultantes de diabetes e insuficiência renal crônica, correspondendo a uma incidência de 3,9% ± 1,7% por paciente/ano. A sobrevida atuarial em 9 anos foi 61,5% ± 9,2%, incluindo a mortalidade cirúrgica e a sobrevida atuarial livre de degeneração tissular estrutural primária do conduto biológico foi de 100%. O corrugamento do pericárdio, resultante da incorporação do princípio crimping utilizado nas próteses vasculares sint

  9. Ruptura de aneurismas de aorta abdominal. Herramienta informática para su predicción // Rupture of abdominal aortic aneurysm. Software for its prediction

    Directory of Open Access Journals (Sweden)

    Guillermo Villalta‐Alonso

    2011-01-01

    Full Text Available La ruptura de los aneurismas de aorta abdominal representa un evento clínico muy importantedebido a su alta tasa de mortalidad. Los indicadores empleados actualmente para decidir eltratamiento a pacientes con aneurismas son el diámetro máximo transversal y la tasa de crecimiento,los que pueden ser considerados insuficientes, pues no tienen una base teórica físicamentefundamentada. En el presente artículo se definen los fundamentos para el diseño de una herramientainformática para PC que permita predecir, con suficiente precisión para ser clínicamente relevante, elriesgo de ruptura de aneurismas de aorta abdominal sobre bases personalizadas del paciente. Laherramienta consta de 3 módulos, que están diseñados para procesar toda la información delpaciente e integrarla mediante un modelo que incorpora la interrelación de los factores biomecánicosde diferentes naturalezas (biológicos, estructurales y geométrico y escalas (temporal y dimensional,con el objetivo de calcular un indicador numérico y personalizado del riesgo de ruptura. Estaherramienta debe constituir un elemento auxiliar del facultativo médico en la toma de decisionesrespecto del tratamiento adecuado a pacientes con aneurisma.Palabras claves: AAA, riesgo de ruptura, modelo multiescala, predicción, herramienta informática.___________________________________________________________________AbstractThe rupture of abdominal aortic aneurysm (AAA represents an important clinical event due to its highmortality rate. Currently the criteria to decide on the treatment of AAA patients are the peaktransverse diameter and the growth rate which can be considered insufficient because they have nota reasonable physical base. The foundations for the design of PC software to predict, with sufficientaccuracy to be clinically relevant, the risk of AAA rupture on patient-specific basis are defined in thispaper. The software consists of 3 modules which are designed for processing all

  10. Resistencia antimicrobiana en aislados de "Escherichia coli" de conejos tratados por vía oral con diferentes pautas de doxiciclina

    OpenAIRE

    Medina Landaeta, Alberto Enrique

    2012-01-01

    La resistencia a antimicrobianos constituye actualmente un problema de gran impacto en Salud Pública. El excesivo uso de antimicrobianos en medicina humana y veterinaria y en agricultura ha originado un incremento continuo de fracasos en la terapia antimicrobiana debido al aumento y diversidad de microorganismos resistentes. La evaluación del riesgo del desarrollo de resistencias cobra especial interés cuando se utilizan pautas de administración por vía oral en animales de abasto, por cuan...

  11. Origem anômala da artéria pulmonar direita em aorta ascendente (hemitruncus Anomalous origin of right pulmonary artery from ascending aorta (hemitruncus

    Directory of Open Access Journals (Sweden)

    Ivan Romero Rivera

    1998-05-01

    Full Text Available A origem da artéria pulmonar direita em aorta ascendente é uma anomalia congênita rara, com poucos casos descritos na literatura. Descrevemos dois casos desta malformação, um associado à interrupção de arco aórtico tipo B. Em ambos, o diagnóstico foi realizado mediante ecocardiografia bidimensional, com confirmação angiográfica em um. A origem da artéria pulmonar direita era próxima à valva aórtica, anomalia patogeneticamente diferente da origem perto da artéria inominada.The origin of the right pulmonary artery from the ascending aorta is a rare congenital anomaly, with very few reports in the literature. We describe two cases of this rare malformation, one of them, associated with interruption of the aortic arch (type B. In both cases, the diagnosis was made by two-dimensional echocardiography, with angiographic confirmation in one of them. The origin of the right pulmonary artery was close to the aortic valve, anomaly pathogenetically distinct from the type that arises close to the innominate artery.

  12. Plaque of atherosclerosis in aorta: review on atherogenesis, formation of plaque, clinical significance, methods of imaging and treatment; Placa de aterosclerose em aorta: revisao sobre aterogenese, formacao de placa, significado clinco, metodos de imagens e tratamento

    Energy Technology Data Exchange (ETDEWEB)

    Furtado, Rogerio Gomes; Nunes, Colandy G. de Oliveira; Rassi Junior, Luis; Melato, Luciano Henrique; Turco, Fabio de Paula; Borges, Moises Marcos, E-mail: rogerinhofurtado@gmail.com [Centro de Diagnostico por Imagem (CDI), Goiania, GO (Brazil); Sara, Leonardo [Instituto do Coracao (InCor/FM/USP), Sao Paulo, SP (Brazil)

    2009-04-15

    There is a certain consensus in the literature that the earliest stage of atherogenesis is characterized by the accumulation of spongy cells in the region of the intimal artery. Risk factors such as arterial hypertension, smoking, diabetes mellitus, hypercholesterolemia, male gender and advanced age predispose a person to the formation of plaques in the coronaries and aorta. A greater number of acute coronary events as well as strokes have been observed in people with these risk factors. Strokes are the third cause of death in the USA, with about 40% of the cases being of cryptogenic origin. Since 1989 the atheroma plaques which develop in the thoracic aorta have been considered to be responsible for cerebral and peripheral strokes which were previously considered cryptogenic because imaging techniques such as electrocardiogram transesophageal, computerized tomogram, nuclear magnetic angio-resonance have visualized and characterized the lesions with plaques of arteriosclerosis in the thoracic aorta. The authors of this article made a systematic review in the PUBMED about arteriosclerosis in the aorta and its diagnostic methods. This review includes the physiopathology of the formation of atheroma to the aorta and its consequences, diagnostic methods such as echo transesophageal, computerized tomogram and angio resonance, as well as the advantages and disadvantages of each method of identification of the lesions. An analysis of the clinical significance of the size, form and location of the atheroma plaques in the thoracic aorta were made based on clinical studies, as well as their treatment with anticoagulants, antiplatelet and drugs to reduce cholesterol. (author)

  13. Robust extraction of the aorta and pulmonary artery from 3D MDCT image data

    Science.gov (United States)

    Taeprasartsit, Pinyo; Higgins, William E.

    2010-03-01

    Accurate definition of the aorta and pulmonary artery from three-dimensional (3D) multi-detector CT (MDCT) images is important for pulmonary applications. This work presents robust methods for defining the aorta and pulmonary artery in the central chest. The methods work on both contrast enhanced and no-contrast 3D MDCT image data. The automatic methods use a common approach employing model fitting and selection and adaptive refinement. During the occasional event that more precise vascular extraction is desired or the method fails, we also have an alternate semi-automatic fail-safe method. The semi-automatic method extracts the vasculature by extending the medial axes into a user-guided direction. A ground-truth study over a series of 40 human 3D MDCT images demonstrates the efficacy, accuracy, robustness, and efficiency of the methods.

  14. [Management of seat-belt aorta in severe polytrauma: a review].

    Science.gov (United States)

    Hornez, E; Bourgouin, S; Baudoin, Y; Prunet, B; Monchal, T; Schlienger, G; Meyrat, L; Thouard, H

    2011-07-01

    Blunt trauma of the abdominal aorta is rare. Secondary to high-energy trauma, it is observed mainly in association with complex lesions. Evaluation of injury to the aorta must be a priority due to the risk of life-threatening massive hemorrhage. The clinical presentation can be quite obvious but also variable and often misleading. If in doubt, a systematic injected whole body scan is essential to diagnose aortic lesions. Hemorrhage or ischemia dictates emergency laparotomy. Opening the retroperitoneum increases the risk of infection if there is an associated gastrointestinal tract injury and may contraindicate use of arterial prostheses. Endovascular treatment can be proposed for less symptomatic lesions, including intimal dissection. Stents can be inserted via a femoral approach. In the event of juxtarenal dissection, there is a risk of renal artery thrombosis. Endovascular treatment is currently not recommended. This treatment can be delayed for a few days if necessary. Morbidity is low and long-term results are good.

  15. Severe diffuse hypoplasia of the aorta associated with multiple vascular abnormalities.

    Science.gov (United States)

    Grebeldinger, Slobodan P; Balj, Svetlana S; Adic, Oto

    2011-06-01

    Hypoplasia of the thoracic and abdominal aorta is an extremely rare vascular pathology. The most common clinical manifestation is severe uncontrolled hypertension in adolescents and young adults. Medical treatment alone can decrease blood pressure, but often very high doses of antihypertensive drugs are needed. When hypertension is refractory to the antihypertensive medications, surgical revascularization is considered as the treatment of choice. We report the case of a severe and diffuse hypoplasia of the aorta, beginning with the aortic isthmus, to the aortic bifurcation, associated with an aberrant celiac trunk and superior mesenteric artery, and with other multiple vascular abnormalities. Unlikely, the only manifestation of this extensive vascular malformation was medicamentously controllable hypertension. To our knowledge, this severe vascular anomaly, with such a minimal clinical manifestation, has not been previously described in the English literature.

  16. Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk

    DEFF Research Database (Denmark)

    Blomberg, Björn A; de Jong, Pim A; Thomassen, Anders;

    2016-01-01

    PURPOSE: Arterial inflammation and vascular calcification are regarded as early prognostic markers of cardiovascular disease (CVD). In this study we investigated the relationship between CVD risk and arterial inflammation ((18)F-FDG PET/CT imaging), vascular calcification metabolism (Na(18)F PET....../CT imaging), and vascular calcium burden (CT imaging) of the thoracic aorta in a population at low CVD risk. METHODS: Study participants underwent blood pressure measurements, blood analyses, and (18)F-FDG and Na(18)F PET/CT imaging. In addition, the 10-year risk for development of CVD, based...... on the Framingham risk score (FRS), was estimated. CVD risk was compared across quartiles of thoracic aorta (18)F-FDG uptake, Na(18)F uptake, and calcium burden on CT. RESULTS: A total of 139 subjects (52 % men, mean age 49 years, age range 21 - 75 years, median FRS 6 %) were evaluated. CVD risk was, on average, 3...

  17. Thoracic aorta calcification but not inflammation is associated with increased cardiovascular disease risk

    DEFF Research Database (Denmark)

    Blomberg, Björn A; de Jong, Pim A; Thomassen, Anders

    2017-01-01

    /CT imaging), and vascular calcium burden (CT imaging) of the thoracic aorta in a population at low CVD risk. METHODS: Study participants underwent blood pressure measurements, blood analyses, and (18)F-FDG and Na(18)F PET/CT imaging. In addition, the 10-year risk for development of CVD, based......PURPOSE: Arterial inflammation and vascular calcification are regarded as early prognostic markers of cardiovascular disease (CVD). In this study we investigated the relationship between CVD risk and arterial inflammation ((18)F-FDG PET/CT imaging), vascular calcification metabolism (Na(18)F PET...... on the Framingham risk score (FRS), was estimated. CVD risk was compared across quartiles of thoracic aorta (18)F-FDG uptake, Na(18)F uptake, and calcium burden on CT. RESULTS: A total of 139 subjects (52 % men, mean age 49 years, age range 21 - 75 years, median FRS 6 %) were evaluated. CVD risk was, on average, 3...

  18. Transvenous digital subtraction angiography (DSA) of the thoracic aorta after surgical correction of aortic coarctation

    Energy Technology Data Exchange (ETDEWEB)

    Arlart, I.P.; Hamann, H.; Stenz, R.

    1985-01-01

    25 patients (normotensive n = 19, hypertensive n = 6) underwent DSA control following corrective surgery of a coarcatation of the thoracic aorta to exclude vascular complications. Simultaneously pressure gradients were determined between upper and lower extremities using the doppler-sonography. DSA was diagnostic in all patients. 2 cases showed a patch-dependent dilatation, in 1 case an anastomotic aneurysm could be demonstrated. In 6 patients with hypoplastic aortic arch and 2 patients with a slight reduction of the diameter in the anastomotic region a pathological pressure-gradient was measured. In these patients the ratio of aortic arch rsp. anastomosis/descending aorta was reduced in diameter (< 0,66) and area (< 44). Hypertension could not be related to pressure gradients or vascular disorders.

  19. Use of noninvasive imaging in the evaluation of coarctation of aorta.

    Science.gov (United States)

    Darabian, Sirous; Zeb, Irfan; Rezaeian, Panteha; Razipour, Aryabod; Budoff, Matthew

    2013-01-01

    Coarctation of the aorta is a congenital heart disease, which is often associated with other cardiac and noncardiac anomalies. Early diagnoses, information about associated anomalies, and defining the severity of the disease are critical for appropriate treatment planning. In this regard, several noninvasive imaging modalities, such as echocardiography, cardiac computed tomography (CT), and cardiac magnetic resonance imaging, have been used. Echocardiography, as an available and safe method, should be used as a primary screening test. It is also useful for intraoperative and hemodynamic studies, but cardiac CT is recommended before any corrective procedure or surgery. Cardiac CT angiography showed an excellent spatial resolution and a good capability for finding associated anomalies. After correction of coarctation of the aorta, serial cardiac magnetic resonance imaging is most commonly performed to avoid repeated radiation exposure.

  20. Traumatic rupture of the thoracic aorta. A review of 49 cases

    Energy Technology Data Exchange (ETDEWEB)

    Stark, P.; Cook, M.; Vincent, A.; Smith, D.C.

    1987-09-01

    We examined retrospectively the chest radiograph of forty-nine patients with angiographically proven aortic ruptures. The plain film findings found most consistently were a wide mediastinum (69.5%), partial obliteration of the descending aorta (67.3%), left apical cap (65.3%), downward displacement of the left main bronchus (65.3%), tracheal deviation to the right (63.2%), obscuration of the aortic arch (55.1%), right paratracheal stripe thickening (53%) and nasogastric tube deviation to the right (50%). We also examined 113 sequential aortograms performed after thoracic trauma over 3 years, to determine the positive rate in our series; 14 studies were positive for a rate of 12.4%. No single case of proved ruptured aorta with a normal chest radiograph was detected.

  1. Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in isolated rat aorta.

    Science.gov (United States)

    Hugghins, S Y; Champion, H C; Cheng, G; Kadowitz, P J; Jeter, J R

    2000-06-16

    The endogenous peptides endomorphins 1 and 2 are newly discovered, potent, selective mu-opioid receptor agonists. In the present study, the effects of endomorphins 1 and 2 on vascular smooth muscle tone were investigated on isolated rings from rat aorta with and without endothelium. In rings precontracted with phenylephrine, endomorphins 1 and 2 at concentrations of 0.1 and 1.0 microM, nociceptin at concentrations of 1-100 microM, and adrenomedullin at concentrations of 0.01-1.0 microM induced concentration dependent relaxant responses. The endomorphins and nociceptin were less potent than adrenomedullin. No relaxation was induced by endomorphins 1 and 2 in aortic rings denuded of endothelium and precontracted with phenylephrine. The results of the present studies demonstrate that the endomorphins relax aortic vascular smooth muscle from the rat aorta by an endothelium-dependant mechanism.

  2. Endovascular treatment of penetrating ulcers of the paraceliac aorta using fenestrated endografts.

    Science.gov (United States)

    Gargiulo, Mauro; Gallitto, Enrico; Freyrie, Antonio; Stella, Andrea

    2014-04-01

    Penetrating atherosclerotic ulcers (PAUs) are usually focal aortic lesions found in patients with significant comorbidities. They are ideal targets for an endovascular approach if localized in the descending thoracic or infrarenal aorta, but when an origin in the visceral vessels is involved, a standard endovascular approach might not be feasible or effective. We report 2 cases of endovascular treatment of PAUs involving the paraceliac abdominal aorta, using a custom-made tube fenestrated endograft with 4 fenestrations for the abdominal visceral vessels (i.e., celiac-trunk, superior mesenteric artery, and renal arteries). There were no intra- or perioperative complications. At 1 year of follow-up, patients were asymptomatic and computed tomography angiography revealed total lesion exclusion and patency of the visceral vessels. The use of a fenestrated endograft is a safe and effective option to treat paraceliac PAUs.

  3. The effects of Vigna unguiculata on cardiac oxidative stress and aorta estrogen receptor-β expression of ovariectomized rats

    Directory of Open Access Journals (Sweden)

    Etik Khusniyati

    2014-12-01

    Conclusions: V. unguiculata is an alternative therapy in decreasing cardiac oxidative stress in ovariectomized rats. Besides, high dose of V. unguiculata also able to increase aorta estrogen receptor-β expression in ovariectomized rats.

  4. Penetrating thoracic spinal cord injury with ice pick extending into the aorta. A technical note and review of the literature

    Directory of Open Access Journals (Sweden)

    Rani Nasser

    2016-01-01

    Conclusion: To the author′s knowledge, this challenging case represents the first description of a successful removal of a penetrating thoracic spinal foreign body that terminated within the lumen of the thoracic aorta.

  5. 18F-FDG PET/CT for Detection Sarcoma of the Aorta in a Patient with Takayasu Arteritis

    Energy Technology Data Exchange (ETDEWEB)

    Yakahashi, Tomoko; Watanabe, Naoto; Wakasa Minoru; Kajinami, Kouji; Tonami, Hisao [Kazazawa Medical Univ., Ishikawa (Japan)

    2016-06-15

    Sarcoma of the aorta is extremely rare; however, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging is a useful modality for detecting malignant tumors, including various sarcomas. We report on a case of sarcoma of the aorta associated concomitantly with Takayasu arteritis. The 18F-FDG PET/CT detected an abnormal increased up take in an aortic mass of the descending thoracic aorta, thoracic vertebra, and ilium. The standardized uptake value (SUV) of 18F-FDG in the aortic mass was 21.7, suggesting that 18F-FDG PET/CT imaging may be useful for detecting sarcoma of the aorta associated with Takayasu arteritis and bone metatases during treatment.

  6. Application of two multi-dimensional analytical methods to histological study of the aorta in dietary atherosclerosis of the rabbit.

    Science.gov (United States)

    Richard, J L; Martin, C; Desecure, J P; Jacotot, B

    1980-01-01

    Multivariate analysis (principal component analysis, discriminant analysis) have been applied to the histological data of arterial lesions in experimental atherosclerosis of the rabbit. We carried out a comparative study of: 1. the lesion observed at three levels of the aortas; origin of the aorta, thoracic aorta and abdominal aorta, and 2. the lesions according to the type of fat ingested during the experimental period. Five edible fats were studied: butter, olive oil, arachid oil, rapeseed oil rich in erucic acid, and rapeseed oil poor in erucic acid (Primor). This study re-affirms the possible importance of the above mentioned methods in evaluation by histology of lesions induced in the arteries by the different hyperlipidic regimens. Indeed these methods are complementary and enable the introduction of statistical methods in the quantitative evaluation of morphological lesions.

  7. Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection

    Institute of Scientific and Technical Information of China (English)

    陈勇; 窦科峰; 何勇; 孙凯

    2003-01-01

    Objective: To study the cause and mechanism of transplantation vasculopathy which characterized by accelerated graft arteriosclerosis (AGA), we established a mouse aorta graft model. Methods: A segment of thoracic aortas of B10.A (2R) mice were transplanted to C57BL/10 mice abdominal aorta by end to side anastomoses. The different time point collected grafts were analyzed by morphological, histochemical and electro microscopic methods. Results: Rejection was manifested as a concentric progressive destruction of the smooth muscle cells. In contrast, the endothelial inflammation and subsequent neointimal proliferation characteristic of AGA was localized to the regions of turbulent flow, i.e. the junction of the graft with the recipient aorta. Conclusion: This model separates the processes of rejection and neointimal formation which usually manifested together in the lesion of AGA, elucidate that different mechanisms control vascular rejection and neointimal formation in chronic rejection.

  8. Effect of niflumic acid on noradrenaline-induced contractions of the rat aorta.

    OpenAIRE

    D.N. Criddle; de Moura,R.S.; Greenwood, I A; Large, W. A.

    1996-01-01

    1. The effects of niflumic acid, an inhibitor of calcium-activated chloride channels, were compared with the actions of the calcium channel antagonist nifedipine on noradrenaline-evoked contractions in isolated preparations of the rat aorta. 2. The cumulative concentration-effect curve to noradrenaline (NA) was depressed by both nifedipine and niflumic acid in a reversible and concentration-dependent manner. The degree of inhibition of the maximal contractile response to NA (1 microM) produce...

  9. Sleeve gastrectomy prevents lipoprotein receptor-1 expression in aortas of obese rats

    Institute of Scientific and Technical Information of China (English)

    Jie Bai; Yong Wang; Yuan Liu; Dong-Hua Geng; Jin-Gang Liu

    2011-01-01

    AIM: To investigate the effects of sleeve gastrectomy on adipose tissue infiltration and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression in rat aortas.METHODS: Twenty-four rats were randomized into three groups: normal chow (control), high fat diet (HD) and high fat diet with sleeve gastrectomy (SG). After surgery, the HD and SG groups were fed a high fat diet. Animals were sacrificed and plasma high density lipoprotein (HDL) and low density lipoprotein (LDL) lev-els were determined. LOX-1 protein and LOX-1 mRNA expression was also measured. Aortas were stained with Nile red to visualize adipose tissue.RESULT: Body weights were higher in the HD group compared to the other groups. HDL levels in control, HD, and SG groups were 32.9 ± 6.2 mg/dL, 43.4 ± 4.0 mg/dL and 37.5 ± 4.3 mg/dL, respectively. LDL levels in control, HD, and SG groups were 31.8 ± 4.5 mg/dL, 53.3 ± 5.1 mg/dL and 40.5 ± 3.7 mg/dL, respectively. LOX-1 protein and LOX-1 mRNA expression was greater in the HD group versus the other groups. Staining for adipose tissue in aortas was greater in the HD group in comparison to the other groups. Thus, a high fat diet elevates LOX-1 protein and mRNA expression in aorta. CONCLUSION: Sleeve gastrectomy decreases plasma LDL levels, and downregulates LOX-1 protein and mRNA expression.

  10. [Deviation of the abdominal aorta and common iliac arteries due to aging and kidney dystopia].

    Science.gov (United States)

    Zhelobtsov, P M

    1982-12-01

    A specific peculiarity in the relief changeability and position of the abdominal aorta, the common iliac arteries is a segmentary deformity occurring in aged persons as a result of atherosclerotic alterations in their walls. A congenital homolateral dystopia, horseshoe and double kidney are rather seldom developmental anomalies in mature persons. In newborns, however, they are found 6-7 times more often and together with other congenital defects of the kidneys make evidently an often cause of the fetal and infantile death.

  11. Aorta-atrial fistula, a rare complication of prosthetic valve endocarditis.

    Science.gov (United States)

    Dewilde, W; Kurvers, M; Jaarsma, W

    2008-05-01

    A 51-year-old male with a history of a mechanical Carbomedics aortic and mitral valve replacement in 2003 and several re-operations because of endocarditis of the mitral valve in 2007 presented with heart failure 68 days after operation. Echocardiography confirmed the presence of a fistulous connection between the aorta and the left atrium. Because of the multiple surgical interventions and high operative risk, an initial conservative medical treatment was initiated and the clinical course was uneventful to this date.

  12. Vasorelaxant action of aqueous extract of the leaves of Persea americana on isolated thoracic rat aorta.

    Science.gov (United States)

    Owolabi, Mbang A; Jaja, Smith I; Coker, Herbert A B

    2005-09-01

    The present study investigated the vasorelaxant action of the aqueous leaves extract of Persea americana on isolated rat aorta. The results showed that the extract produced significant vasorelaxation and that the effect is dependent on the synthesis or release of endothelium-derived relaxing factors (EDRFs) as well as the release of prostanoid. The extract also reduced vasoconstriction probably by inhibiting Ca2+ influx through calcium channels.

  13. Computer-aided patch planning for treatment of complex coarctation of the aorta

    Science.gov (United States)

    Rietdorf, Urte; Riesenkampff, Eugénie; Kuehne, Titus; Huebler, Michael; Meinzer, Hans-Peter; Wolf, Ivo

    2009-02-01

    Between five and eight percent of all children born with congenitally malformed hearts suffer from coarctations of the aorta. Some severe coarctations can only be treated by surgical repair. Untreated, this defect can cause serious damage to organ development or even lead to death. Patch repair requires open surgery. It can affect patients of any age: newborns with severe coarctation and/or hypoplastic aortic arch as well as older patients with late diagnosis of coarctation of the aorta. Another patient group are patients of varying age with re-coarctation of the aorta or hypoplastic aortic arch after surgical and/or interventional repair. If anatomy is complex and interventional treatment by catheterization, balloon angioplasty or stent placement is not possible, surgery is indicated. The choice of type of surgery depends not only on the given anatomy but also on the experience the surgical team has with each method. One surgical approach is patch repair. A patch of a suitable shape and size is sewed into the aorta to expand the aortic lumen at the site of coarctation. At present, the shape and size of the patch are estimated intra-operatively by the surgeon. We have developed a software application that allows planning of the patch pre-operatively on the basis of magnetic resonance angiographic data. The application determines the diameter of the coarctation and/or hypoplastic segment and constructs a patch proposal by calculating the difference to the normal vessel diameter pre-operatively. Evaluation of MR angiographic datasets from 12 test patients with different kinds of aortic arch stenosis shows a divergence of only (1.5+/-1.2) mm in coarctation diameters between manual segmentations and our approach, with comparable time expenditure. Following this proposal the patch can be prepared and adapted to the patient's anatomy pre-operatively. Ideally, this leads to shorter operation times and a better long-term outcome with a reduced rate of residual stenosis and

  14. Levosimendan in a neonate with severe coarctation of aorta and low cardiac output syndrome

    Directory of Open Access Journals (Sweden)

    Yann Olivier Boegli

    2013-01-01

    Full Text Available We report successful use of levosimendan after failed balloon angioplasty in a critically ill neonate with coarctation of aorta (CoA and severe low cardiac output syndrome (LCOS. Treatment with levosimendan improved left heart function, and decreased lactate and brain natriuretic peptide levels. To our knowledge, this is the first report on the safe and successful use of levosimendan in the management of LCOS due to severe CoA in a neonate awaiting surgical repair.

  15. Coarctation of the aorta and vein of Galen malformation - treatment considerations in a severely compromised patient.

    Science.gov (United States)

    Emmel, Mathias; Bennink, Gerardus; Meila, Dan; Brassel, Friedhelm

    2012-10-01

    A vein of Galen malformation - a rare cause of cardiac insufficiency in neonates - is sometimes associated with coarctation of the aorta, two diseases requiring urgent therapy in the neonatal period. We report on a term neonate in whom we first palliated the coarctation by stent implantation, providing time to treat the vein of Galen malformation by endovascular embolisation. Following this, the coarctation was surgically repaired and the stent was explanted.

  16. Right Minithoracotomy Approach for Replacement of the Ascending Aorta, Hemiarch, and Aortic Valve.

    Science.gov (United States)

    Lamelas, Joseph; LaPietra, Angelo

    2016-01-01

    A minimally invasive right anterior thoracotomy approach is the preferred technique used at our institution for isolated aortic valve pathology. We have recently introduced more complex concomitant minimally invasive procedures through this access site. Here, we describe how we perform a replacement of the ascending aorta and aortic valve with and without the use of circulatory arrest through a 6-cm right minimally invasive thoracotomy incision.

  17. Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing.

    Science.gov (United States)

    Rukov, Jakob L; Gravesen, Eva; Mace, Maria L; Hofman-Bang, Jacob; Vinther, Jeppe; Andersen, Claus B; Lewin, Ewa; Olgaard, Klaus

    2016-03-15

    The development of vascular calcification (VC) in chronic uremia (CU) is a tightly regulated process controlled by factors promoting and inhibiting mineralization. Next-generation high-throughput RNA sequencing (RNA-seq) is a powerful and sensitive tool for quantitative gene expression profiling and the detection of differentially expressed genes. In the present study, we, for the first time, used RNA-seq to examine rat aorta transcriptomes from CU rats compared with control rats. Severe VC was induced in CU rats, which lead to extensive changes in the transcriptional profile. Among the 10,153 genes with an expression level of >1 reads/kilobase transcript/million mapped reads, 2,663 genes were differentially expressed with 47% upregulated genes and 53% downregulated genes in uremic rats. Significantly deregulated genes were enriched for ontologies related to the extracellular matrix, response to wounding, organic substance, and ossification. The individually affected genes were of relevance to osteogenic transformation, tissue calcification, and Wnt modulation. Downregulation of the Klotho gene in uremia is believed to be involved in the development of VC, but it is debated whether the effect is caused by circulating Klotho only or if Klotho is produced locally in the vasculature. We found that Klotho was neither expressed in the normal aorta nor calcified aorta by RNA-seq. In conclusion, we demonstrated extensive changes in the transcriptional profile of the uremic calcified aorta, which were consistent with a shift in phenotype from vascular tissue toward an osteochondrocytic transcriptome profile. Moreover, neither the normal vasculature nor calcified vasculature in CU expresses Klotho.

  18. Continuum analysis of common branching patterns in the human arch of the aorta.

    Science.gov (United States)

    Zamir, M; Sinclair, P

    1990-01-01

    A model is proposed for describing common variations in the arrangement of branches on the arch of the human aorta, and the model is used to analyze data from 123 human arches. The analysis allows the observed variations to fall freely along a continuous spectrum, rather than be confined to discrete categories as is commonly done at present. The results thus describe these variations in a more natural way and throw some new light on their likely source.

  19. [TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings.

    Science.gov (United States)

    Zhao, Qian-Yu; Chen, Qiang; Feng, Yun; Lin, Xin; Wang, Rui

    2005-05-01

    [Tic(4)]EM1 and [Tic(4)]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic(4)]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor.

  20. Anatomy of the bovine ascending aorta and brachiocephalic artery found unfavorable for total artificial heart implant.

    Science.gov (United States)

    Karimov, Jamshid H; Sunagawa, Gengo; Such, Kimberly A; Sale, Shiva; Golding, Leonard A R; Moazami, Nader; Fukamachi, Kiyotaka

    2015-12-01

    The biocompatibility assessment of the Cleveland Clinic continuous-flow total artificial heart is an important part of the device developmental program. Surgical and postoperative management are key factors in achieving optimal outcomes. However, the presence of vascular anatomical abnormalities in experimental animal models is often unpredictable and may worsen the expected outcomes. We report a technical impediment encountered during total artificial heart implantation complicated by unfavorable bovine anatomy of the ascending aorta and brachiocephalic arterial trunk.

  1. Mycotic Abdominal Aortic Aneurysm Secondary to Septic Embolism of a Thoracic Aorta Graft Infection.

    Science.gov (United States)

    Blanco Amil, Carla Lorena; Vidal Rey, Jorge; López Arquillo, Irene; Pérez Rodríguez, María Teresa; Encisa de Sá, José Manuel

    2016-05-01

    Mycotic aneurysms account for 1% of abdominal aortic aneurysms. There are very few cases published that describe the formation of mycotic aneurysms after septic embolism due to graft infection. We present the first case to our knowledge to be described in the literature of a mycotic aneurysm caused by septic embolism derived from a thoracic aorta graft infection, treated with conventional surgery leading to a successful outcome and evolution.

  2. Involvement of the aorta in brucellosis: the forgotten, life-threatening complication. A systematic review.

    Science.gov (United States)

    Cascio, Antonio; De Caridi, Giovanni; Lentini, Salvatore; Benedetto, Filippo; Stilo, Francesco; Passari, Gabriele; Iaria, Chiara; Spinelli, Francesco; Pappas, Georgios

    2012-10-01

    Human brucellosis is a disease of protean manifestations, and has been implicated in complications and focal disease in many human organ systems. However, little is collectively known about the background, the course, the clinical characteristics, the diagnostic issues raised, and the short- and long-term therapeutic approaches in patients with aortic involvement as a complication of brucellosis. With the aim to glean from the literature useful information to better understand and manage this complication, a computerized search without language restriction was conducted using PubMed and SCOPUS. An article was considered eligible for inclusion in the systematic review if it reported data on patients with involvement of the aorta due to a Brucella infection. The epidemiologic and clinical characteristics of 44 cases of brucellar aortic involvement found through the systematic review of the literature were analyzed together with those of two new cases that we treated in the recent past. This complication involved the ascending thoracic aorta in 18 cases (in 16 of them as a consequence of brucellar endocarditis), and the descending thoracic aorta or the abdominal aorta in the remaining 30 cases. In the latter it was associated with spondylodiscitis of the lumbar spine in 13 cases. History of or symptoms indicative of brucellosis were not universally present. Brucellar aortic involvement represents a possibly underdiagnosed and underreported complication with major morbidity and mortality potential. Experience with novel invasive therapeutic approaches remains limited. Early suspicion through detailed history and diagnosis, aided by advances in aortic imaging, would allow for better planning of therapeutic interventions.

  3. Analysis of Systolic Backflow and Secondary Helical Blood Flow in the Ascending Aorta Using Vector Flow Imaging

    DEFF Research Database (Denmark)

    Hansen, Kristoffer Lindskov; Møller-Sørensen, Hasse; Kjaergaard, Jesper

    2016-01-01

    Secondary rotational flow and systolic backflow are seen in the ascending aorta and, in this study, were analyzed with the vector velocity method transverse oscillation. Twenty-five patients were scanned intra-operatively, and the vector velocities were related to estimates of transesophageal...... that backflow is injurious and that secondary flow is a normal flow phenomenon. The study also shows that transverse oscillation can provide new information on blood flow in the ascending aorta....

  4. Transcriptional and phenotypic changes in aorta and aortic valve with aging and MnSOD deficiency in mice.

    Science.gov (United States)

    Roos, Carolyn M; Hagler, Michael; Zhang, Bin; Oehler, Elise A; Arghami, Arman; Miller, Jordan D

    2013-11-15

    The purpose of this study was to characterize changes in antioxidant and age-related gene expression in aorta and aortic valve with aging, and test the hypothesis that increased mitochondrial oxidative stress accelerates age-related endothelial and aortic valve dysfunction. Wild-type (MnSOD(+/+)) and manganese SOD heterozygous haploinsufficient (MnSOD(+/-)) mice were studied at 3 and 18 mo of age. In aorta from wild-type mice, antioxidant expression was preserved, although there were age-associated increases in Nox2 expression. Haploinsufficiency of MnSOD did not alter antioxidant expression in aorta, but increased expression of Nox2. When compared with that of aorta, age-associated reductions in antioxidant expression were larger in aortic valves from wild-type and MnSOD haploinsufficient mice, although Nox2 expression was unchanged. Similarly, sirtuin expression was relatively well-preserved in aorta from both genotypes, whereas expression of SIRT1, SIRT2, SIRT3, SIRT4, and SIRT6 were significantly reduced in the aortic valve. Expression of p16(ink4a), a marker of cellular senescence, was profoundly increased in both aorta and aortic valve from MnSOD(+/+) and MnSOD(+/-) mice. Functionally, we observed comparable age-associated reductions in endothelial function in aorta from both MnSOD(+/+) and MnSOD(+/-) mice. Interestingly, inhibition of NAD(P)H oxidase with apocynin or gp91ds-tat improved endothelial function in MnSOD(+/+) mice but significantly impaired endothelial function in MnSOD(+/-) mice at both ages. Aortic valve function was not impaired by aging or MnSOD haploinsufficiency. Changes in antioxidant and sirtuin gene expression with aging differ dramatically between aorta and aortic valve. Furthermore, although MnSOD does not result in overt cardiovascular dysfunction with aging, compensatory transcriptional responses to MnSOD deficiency appear to be tissue specific.

  5. Automatic aorta segmentation and valve landmark detection in C-arm CT for transcatheter aortic valve implantation.

    Science.gov (United States)

    Zheng, Yefeng; John, Matthias; Liao, Rui; Nöttling, Alois; Boese, Jan; Kempfert, Jörg; Walther, Thomas; Brockmann, Gernot; Comaniciu, Dorin

    2012-12-01

    Transcatheter aortic valve implantation (TAVI) is a minimally invasive procedure to treat severe aortic valve stenosis. As an emerging imaging technique, C-arm computed tomography (CT) plays a more and more important role in TAVI on both pre-operative surgical planning (e.g., providing 3-D valve measurements) and intra-operative guidance (e.g., determining a proper C-arm angulation). Automatic aorta segmentation and aortic valve landmark detection in a C-arm CT volume facilitate the seamless integration of C-arm CT into the TAVI workflow and improve the patient care. In this paper, we present a part-based aorta segmentation approach, which can handle structural variation of the aorta in case that the aortic arch and descending aorta are missing in the volume. The whole aorta model is split into four parts: aortic root, ascending aorta, aortic arch, and descending aorta. Discriminative learning is applied to train a detector for each part separately to exploit the rich domain knowledge embedded in an expert-annotated dataset. Eight important aortic valve landmarks (three hinges, three commissures, and two coronary ostia) are also detected automatically with an efficient hierarchical approach. Our approach is robust under all kinds of variations observed in a real clinical setting, including changes in the field-of-view, contrast agent injection, scan timing, and aortic valve regurgitation. Taking about 1.1 s to process a volume, it is also computationally efficient. Under the guidance of the automatically extracted patient-specific aorta model, the physicians can properly determine the C-arm angulation and deploy the prosthetic valve. Promising outcomes have been achieved in real clinical applications.

  6. Retained guidewire penetrating through the aorta into the thorax: an unusual cause of recurrent bilateral pneumothorax.

    Science.gov (United States)

    Kim, YongHun; Yu, JunSik; Kim, YoHan; Lee, WooSurng

    2016-01-01

    Although numerous complications of the Seldinger technique have been reported in the literature, only a few complications are related to guidewires. We here report a case of a patient with a guidewire lost and retained in the aorta during vertebral artery stenting. Unfortunately, the guidewire in the aorta was not detected for 5 years, and it penetrated through the aorta into the left thorax, leading to recurrent left pneumothorax. No physician identified the wandering guidewire in the left thorax, and the recurrent left pneumothorax was only managed with closed thoracostomy drainage several times. After 4 months, the patient presented to our hospital with repeated severe chest pain, and newly developed right pneumothorax was diagnosed on chest X-rays. We meticulously evaluated the radiological findings of the other hospitals to identify the cause of the recurrent pneumothorax and discovered that the lost and wandering guidewire had crossed over from the left to the right thorax through the anterior mediastinum. The guidewire was identified as the cause of the recurrent bilateral pneumothorax, and the patient was successfully treated with video-assisted thoracoscopic surgery without any events.

  7. Morphological description of collateral branches from the abdominal aorta of lesser anteater (Tamandua tetradactyla

    Directory of Open Access Journals (Sweden)

    Breno Costa Macedo

    2013-03-01

    Full Text Available Tamandua tetradactyla, Xenarthra, is a native species from South America which, due to the few number of studies on its biology, still has many unknown aspects in its morphology. Taking into account the importance of morphological data for various studies, this paper aimed to elucidate the branching of the abdominal aorta in this species to foster the development of further studies. To do this, 4 specimens were used, 2 male and 2 female, all young, from the Bauxite Mine – Paragominas, Para, Brazil, donated after death due to running over to the Animal Morphology Research Laboratory (LaPMA of Universidade Federal Rural da Amazonia (UFRA. The arterial system was filled with contrasted latex and the animals were fixed in a formaldehyde solution (10%, and then dissected, in order to evidence the abdominal aorta and its collateral branches. The parietal branches consisted of 1 pair of caudal phrenic arteries, 2 pairs of intercostal arteries, and 3 pairs of lumbar arteries. Among the visceral branches, stood out: celiac artery; cranial mesenteric artery; adrenal arteries; renal arteries; caudal mesenteric artery; and external, internal, and median sacral iliac arteries, formed from the final portion of the abdominal aorta. Testicular and ovarian arteries originated from the renal arteries, differing from that described in various species.

  8. Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

    Directory of Open Access Journals (Sweden)

    Marco Matteo Ciccone

    2013-01-01

    Full Text Available Aim. To evaluate the influence of selected maternal and neonatal characteristics on aorta walls in term, appropriately grown-for-gestational age newborns. Methods. Age, parity, previous abortions, weight, height, body mass index before and after delivery, smoking, and history of hypertension, of diabetes, of cardiovascular diseases, and of dyslipidemia were all assessed in seventy mothers. They delivered 34 males and 36 females healthy term newborns who underwent ultrasound evaluation of the anteroposterior infrarenal abdominal aorta diameter (APAO, biochemical profile (glucose, insulin, total cholesterol, HDL and LDL cholesterol, triglycerides, fibrinogen, and D-dimers homeostasis model assessment [HOMAIR]index, and biometric parameters. Results. APAO was related to newborn length (r=+0.36; P=0.001, head circumference (r=+0.37; P=0.001, gestational age (r=+0.40, P=0.0005, HOMA index (r=+0.24; P=0.04, and D-dimers (r=+0.33, P=0.004. Smoke influenced APAO values (odds ratio: 1.80; confidence interval 95%: 1.05–3.30, as well as diabetes during pregnancy (r=+0.42, P=0.0002. Maternal height influenced neonatal APAO (r=+0.47, P=0.00003. Multiple regression analysis outlined neonatal D-dimers as still significantly related to neonatal APAO values. Conclusions. Many maternal and neonatal characteristics could influence aorta structures. Neonatal D-dimers are independently related to APAO.

  9. [Visco-elastic characteristics of the aorta in conscious dogs in a model of experimental calcinosis].

    Science.gov (United States)

    Armentano, R; Levenson, J; Cabrera, E; Pichel, R; Simon, A

    1989-07-01

    Effects of experimental calcinosis induced by daily overdose of 500.000 IU Vit D3 during 10 days were studied in 6 mongrel conscious dogs chronically instrumented with intra-aortic Konigsberg microtransducer and two ultrasonic piezo-electric crystals diametrically opposed in the adventitia of the descending thoracic aorta. Simultaneous recording of instantaneous aortic pressure and diameter waves in basal state and during transient acute hypertension induced by intravenous angiotensin bolus (0.1 microgram/kg) allowed to obtain the pressure (y) diameter (x) relationship of the aorta according to an exponential regression: P = expo (beta D + A), with a highly significant correlation coefficient in all animals (r greater than 0.99). (table; see text) Anatomopathological studies of aortas revealed abnormal calcium deposition, ruptures of elastic fibers and disorganization of collagen. Thus, a striking decrease in aortic rigidity is observed after calcinosis in relation with structural changes of elastic materials and responsible in part for a reduction in pulsatile pressure; moreover this unexpected phenomena might represent an initiative process of development of aortic aneurysms.

  10. Aneurisma de aorta com ruptura para esôfago Aortic aneurysm rupture into the esophagus

    Directory of Open Access Journals (Sweden)

    Christiano da Silveira de Barcellos

    2008-12-01

    Full Text Available Apresentamos o caso de uma paciente portadora de aneurisma de aorta descendente com ruptura para o esôfago que, após aortoplastia com interposição de tubo de dacron e rafia da laceração esofágica, evoluiu com fístula esôfago pleural no terceiro dia pós-operatório. A paciente necessitou de reintervenção e cuidados intensivos, reabilitando-se adequadamente. A propósito deste caso incomum e do aprendizado adquirido no seu manejo, revisamos a literatura a fim de discutir a melhor alternativa de correção desta rara e, freqüentemente, fatal forma de apresentação das doenças da aorta.We present the case of a patient with a descending aorta aneurysm rupture into the esophagus, which, after aortoplasty with Dacron tube interposition and suture of esophageal laceration, developed a pleural-esophagus fistula on the 3rd postoperative day. She needed re-intervention and intensive care, followed by adequate recovery. Considering this unusual case and the knowledge acquired through its management, we reviewed the literature in order to discuss the best alternative for the correction of this rare and often fatal form of presentation of aortic diseases.

  11. Respiratory displacement of the thoracic aorta: physiological phenomenon with potential implications for thoracic endovascular repair.

    Science.gov (United States)

    Weber, Tim Frederik; Tetzlaff, Ralf; Rengier, Fabian; Geisbüsch, Philipp; Kopp-Schneider, Annette; Böckler, Dittmar; Eichinger, Monika; Kauczor, Hans-Ulrich; von Tengg-Kobligk, Hendrik

    2009-07-01

    The purpose of this study was to assess the magnitude and direction of respiratory displacement of the ascending and descending thoracic aorta during breathing maneuvers. In 11 healthy nonsmokers, dynamic magnetic resonance imaging was performed in transverse orientation at the tracheal bifurcation during maximum expiration and inspiration as well as tidal breathing. The magnitude and direction of aortic displacement was determined relatively to resting respiratory position for the ascending (AA) and descending (DA) aorta. To estimate a respiratory threshold for occurrence of distinct respiratory aortic motion, the latter was related to the underlying change in anterior-posterior thorax diameter. Compound displacement between maximum expiration and inspiration was 24.3 +/- 6.0 mm for the AA in the left anterior direction and 18.2 +/- 5.5 mm for the DA in the right anterior direction. The mean respiratory thorax excursion during tidal breathing was 8.9 +/- 2.8 mm. The respiratory threshold, i.e., the increase in thorax diameter necessary to result in respiratory aortic displacement, was estimated to be 15.7 mm. The data suggest that after a threshold of respiratory thorax excursion is exceeded, respiration is accompanied by significant displacement of the thoracic aorta. Although this threshold may not be reached during tidal breathing in the majority of individuals, segmental differences during forced respiration impact on aortic geometry, may result in additional extrinsic forces on the aortic wall, and may be of significance for aortic prostheses designed for thoracic endovascular aortic repair.

  12. The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta

    Directory of Open Access Journals (Sweden)

    Ivković Branka

    2013-01-01

    Full Text Available The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM, but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary.

  13. Experimental study of aortic flow in the ascending aorta via Particle Tracking Velocimetry

    Science.gov (United States)

    Gülan, Utku; Lüthi, Beat; Holzner, Markus; Liberzon, Alex; Tsinober, Arkady; Kinzelbach, Wolfgang

    2012-11-01

    A three-dimensional, pulsatile flow in a realistic phantom of a human ascending aorta with compliant walls is investigated in vitro. Three-Dimensional Particle Tracking Velocimetry (3D-PTV), an image-based, non-intrusive measuring method is used to analyze the aortic flow. The flow velocities and the turbulent fluctuations are determined. The velocity profile at the inlet of the ascending aorta is relatively flat with a skewed profile toward the inner aortic wall in the early systole. In the diastolic phase, a bidirectional flow is observed with a pronounced retrograde flow developing along the inner aortic wall, whereas the antegrade flow migrates toward the outer wall of the aorta. The spatial and temporal evolution of the vorticity field shows that the vortices begin developing along the inner wall during the deceleration phase and attenuate in the diastolic phase. The change in the cross-sectional area is more distinct distal to the inlet cross section. The mean kinetic energy is maximal in the peak systole, whereas the turbulent kinetic energy increases in the deceleration phase and reaches a maximum in the beginning of the diastolic phase. Finally, in a Lagrangian analysis, the temporal evolution of particle dispersion was studied. It shows that the dispersion is higher in the deceleration phase and in the beginning of the diastole, whereas in systole, it is smaller but non-negligible.

  14. Abnormal Wave Reflections and Left Ventricular Hypertrophy Late After Coarctation of the Aorta Repair

    Science.gov (United States)

    Quail, Michael A.; Short, Rebekah; Pandya, Bejal; Steeden, Jennifer A.; Khushnood, Abbas; Taylor, Andrew M.; Segers, Patrick

    2017-01-01

    Patients with repaired coarctation of the aorta are thought to have increased afterload due to abnormalities in vessel structure and function. We have developed a novel cardiovascular magnetic resonance protocol that allows assessment of central hemodynamics, including central aortic systolic blood pressure, resistance, total arterial compliance, pulse wave velocity, and wave reflections. The main study aims were to (1) characterize group differences in central aortic systolic blood pressure and peripheral systolic blood pressure, (2) comprehensively evaluate afterload (including wave reflections) in the 2 groups, and (3) identify possible biomarkers among covariates associated with elevated left ventricular mass (LVM). Fifty adult patients with repaired coarctation and 25 age- and sex-matched controls were recruited. Ascending aorta area and flow waveforms were obtained using a high temporal-resolution spiral phase-contrast cardiovascular magnetic resonance flow sequence. These data were used to derive central hemodynamics and to perform wave intensity analysis noninvasively. Covariates associated with LVM were assessed using multivariable linear regression analysis. There were no significant group differences (P≥0.1) in brachial systolic, mean, or diastolic BP. However central aortic systolic blood pressure was significantly higher in patients compared with controls (113 versus 107 mm Hg, P=0.002). Patients had reduced total arterial compliance, increased pulse wave velocity, and larger backward compression waves compared with controls. LVM index was significantly higher in patients than controls (72 versus 59 g/m2, Pcoarctation of the aorta repair, including abnormal wave reflections that are associated with elevated LVM. PMID:28115510

  15. Decellularized aorta of fetal pigs as a potential scaffold for small diameter tissue engineered vascular graft

    Institute of Scientific and Technical Information of China (English)

    LIU Guo-feng; HE Zhi-juan; YANG Da-ping; HAN Xue-feng; GUO Tie-fang; HAO Chen-guang; MA Hui; NIE Chun-lei

    2008-01-01

    Background For cardiovascular tissue engineering, acellularized biomaterials from pig have been widely investigated. Our purpose was to study mechanical properties and biocompatibility of decellularized aorta of fetal pigs (DAFP) to determine its potential as scaffold for small diameter tissue engineered vascular graft.Methods Descending aorta of fetal pigs was removed cells using trypsin, ribonuclease and desoxyribonuclease. Mechanical properties of DAFP were evaluated by tensile stress-strain and burst pressure analysis. Assessment of cell adhesion and compatibility was conducted by seeding porcine aortic endothelial cells. To evaluate biocompatibility in vivo, DAFP was implanted subcutaneously into adult male Sprague Dawley rats for 2, 4 and 8 weeks.Results Histochemistry and scanning electron microscopy examination of DAFP revealed well-preserved extracellular matrix proteins and porous three-dimensional structures. Compared with fresh aorta, DAFP had similar ultimate tensile strength, axial compliance and burst pressure. Cell culture studies in vitro showed that porcine aortic endothelial cells adhered and proliferated on the surfaces of DAFP with excellent cell viability. Subdermal implantation demonstrated that the DAFP did not show almost any immunological reaction and exhibited minimal calcification during the whole follow-up period.Conclusion The DAFP has the potential to serve as scaffolds for small diameter tissue engineered vascular graft.

  16. Thymoquinone protects end organs from abdominal aorta ischemia/reperfusion injury in a rat model

    Directory of Open Access Journals (Sweden)

    Mehmet Salih Aydin

    2015-02-01

    Full Text Available Introduction: Previous studies have demonstrated that thymoquinone has protective effects against ischemia reperfusion injury to various organs like lungs, kidneys and liver in different experimental models. Objective: We aimed to determine whether thymoquinone has favorable effects on lung, renal, heart tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. Methods: Thirty rats were divided into three groups as sham (n=10, control (n=10 and thymoquinone (TQ treatment group (n=10. Control and TQ-treatment groups underwent abdominal aorta ischemia for 45 minutes followed by a 120-min period of reperfusion. In the TQ-treatment group, thymoquinone was given 5 minutes. before reperfusion at a dose of 20 mg/kg via an intraperitoneal route. Total antioxidant capacity, total oxidative status (TOS, and oxidative stress index (OSI in blood serum were measured and lung, kidney, and heart tissue histopathology were evaluated with light microscopy. Results: Total oxidative status and oxidative stress index activity in blood samples were statistically higher in the control group compared to the sham and TQ-treatment groups (P<0.001 for TOS and OSI. Control group injury scores were statistically higher compared to sham and TQ-treatment groups (P<0.001 for all comparisons. Conclusion: Thymoquinone administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta ischemia-reperfusion rat model.

  17. Redo mitral valve replacement through a right mini-thoracotomy with an unclamped aorta.

    Science.gov (United States)

    Botta, Luca; Fratto, Pasquale; Cannata, Aldo; Bruschi, Giuseppe; Merlanti, Bruno; Brignani, Christian; Bosi, Mauro; Martinelli, Luigi

    2014-08-14

    Redo cardiac surgery represents a clinical challenge due to a higher rate of perioperative morbidity and mortality. Mitral valve (MV) re operations can particularly be demanding in patients with patent coronary grafts, previous aortic valve replacement, calcified aorta or complications following a previous operation (abscesses, leaks or thrombosis). In this article we describe our technique to manage complex mitral reoperations using a minimally invasive approach, moderate hypothermia and avoiding aortic cross-clamping. Minimally invasive procedures with an unclamped aorta have the potential to combine the benefits of less invasive access and continuous myocardial perfusion. The advantage of a right mini-thoracotomy is the avoidance of sternal re-entry and limited dissection of adhesions, reducing the risk of cardiac structures or patent graft injury. Moderate hypothermia and continuous blood perfusion can guarantee adequate myocardial protection particularly in the case of patent grafts, decreasing the dangers of an incomplete or imperfect aortic clamping at mild hypothermia and potential lesions due to demanding clamp placing. Complex MV reoperations can be safely and effectively performed through a smaller right thoracotomy in the fourth intercostal space with an unclamped aorta.

  18. Bolus timing in high-pitch CT angiography of the aorta

    Energy Technology Data Exchange (ETDEWEB)

    Beeres, Martin, E-mail: beeres@gmx.net [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Loch, Matthias, E-mail: MatthiasLoch@gmx.net [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Schulz, Boris, E-mail: boris.schell@googlemail.com [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Kerl, Matthias, E-mail: matthias.kerl@gmail.com [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Al-Butmeh, Firas, E-mail: Firas.Albutmeh@gmail.com [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Bodelle, Boris, E-mail: bbodelle@googlemail.com [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Herrmann, Eva, E-mail: Herrmann@Med.Uni-Frankfurt.de [Clinic of the Goethe University, Department of Biostatistics, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Gruber-Rouh, Tatjana, E-mail: tatjanagruber2004@yahoo.de [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Lee, Clara, E-mail: Clara.Lee@kgu.de [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Jacobi, Volkmar, E-mail: Volkmar.Jacobi@kgu.de [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); Vogl, Thomas J., E-mail: T.Vogl@em.uni-frankfurt.de [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Theodor-Stern-Kai 7, 60590 Frankfurt (Germany); and others

    2013-06-15

    Objective: To investigate the bolus geometry in high-pitch CT angiography (CTA) of the aorta without ECG synchronisation in comparison to single-source CT. Methods: Overall 160 consecutive patients underwent CTA either in conventional single-source mode with a pitch of 1.2 (group 1), or in dual-source mode with a pitch of 3.0 (groups 2, 3 and 4) using different contrast media timings with bolus triggering at 140 HU (5 s, group 1; 10 s, group 2; 12 s, group 3; 14 s, group 4). Contrast material, saline flush, flow rate and kV/mAs settings were kept equal for optimum comparability. Aortic attenuation was measured along the z-axis of the patient at different anatomic landmarks and subjective image quality was compared. Results: The most homogeneous enhancement of the aorta was reached with a delay of 10 s after reaching the trigger threshold. The imaging length was not significantly different, but the examination time was significantly (p < 0.001) shorter in the high-pitch group (7.7 s vs. 1.7 s for group 1 vs. 2, 3 and 4). Conclusion: In high-pitch CT angiography using a start delay of 10 s after a trigger threshold of 140 HU in the descending aorta is reached, a homogenous contrast along the z-axis is accomplished.

  19. Clinical analysis of abdominal aorta block in operation of gynecologic tumor

    Institute of Scientific and Technical Information of China (English)

    MU Yu-lan; TANG Chun-sheng; WEN Ze-qing; YIN Fu-bo; LIU Ming

    2006-01-01

    Objective:To evaluate the clinical effects of the abdominal aorta block in controlling haemorrhage during operations of the gynecologic tumor. Methods: From July 1965 to January 2005, we collected patients (n= 49) of gynecologic tumor complicated with haemorrhage during operations, who were divided into 3 groups: preventive blocking group (PG, n= 12), treatment blocking group (TG, n= 20) used abdominal aorta block technique with sterilized cotton band and silica gel tube, and control group (CG, n=17) which were used the regular haemostatic methods, such as ligature, suture and ribbon gauze packing.During operations, the vital signs including the amount of bleeding and transfusion were measured. Results: Compared with the CG, the amount of bleeding and transfusion in the PG and TG decreased significantly (P<0.01). After using the technique, 32 cases of haemorrhage were controlled completely. All patients finished operation smoothly in the end and the vital signs were stable. The vision field of operation was clear and the operating time was shortened dramatically (3.0 h vs 5.7 h and 3.8 h vs 5.7 h, P<0.01). No complications caused by the block occurred in the post-operation. Conclusion: Lower abdominal aorta block is safe and effective in controlling haemorrhage during operations of the gynecologic tumor.

  20. Early impact of aortic wrapping on patients undergoing aortic valve replacement with mild to moderate ascending aorta dilatation

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    Sosnowski Andrzej

    2010-08-01

    Full Text Available Abstract Background The management of mild to moderate dilatation of the ascending aorta of less than 5 cm is controversial, particularly when concomitant surgical correction of aortic valve is required. We investigate the impact of a simple method of aorta reduction using Dacron graft wrapping during aortic valve replacement on the rest of the aorta. Methods We studied 14 patients who had ascending aorta dilatation of 4-5 cm before undergoing aortic wrapping during their aortic valve replacement and compared with their post-operative imaging within a month. Results The diameters of the ascending aorta wrapped with the Dacron graft were significantly reduced within 4 weeks after surgery from 44.7 ± 2.6 to 33.6 ± 3.9 mm (p Conclusions Reduction of ascending aortic dilatation by wrapping with a Dacron graft in this preliminary study is associated with favourable early reversed aortic remodelling. This supports the hypothesis that correction of mild-moderate dilatation of the ascending aorta with Dacron wrapping at the time of aortic valve surgery may prevent the progression of the dilatation, although the long-term study on a larger population is needed to confirm its benefits.

  1. Clinical Study of the Ascending Aorta Wall Motion by Velocity Vector Imaging in Patients with Primary Hypertension

    Institute of Scientific and Technical Information of China (English)

    Lei WANG; Jing WANG; Mingxing XIE; Xinfang WANG; Qing LV; Ming CHEN; Shaoping ZHENG

    2009-01-01

    We studied the wall motion characteristics of the ascending aorta by velocity vector im-aging (VVI) in primary hypertension patients.The ascending aortas both in 30 patients with primary hypertension and 30 normal controls were examined by Acuson sequoia 512 equiped with VVI.The maximum velocity (Vs,Ve) of every point on the anterior wall of ascending aorta both in systole and diastole was measured.The aortic diameter was wider in the hypertension patients than that in the healthy subjects (P0.05).The velocity curves of the anterior wall of ascending aorta both in the hypertension and healthy subjects were regular,and the curve in systole was named S wave and that in diastole named E wave.The velocity of S wave and E wave was slower in the hypertension pa-tients than that in the healthy subjects (P<0.05).The time to peak of S wave on the anterior wall of ascending aorta in systole was shorter in the hypertension patients than in the healthy subjects (P<0.05).VVI could be used to accurately and directly observe the movement character of the as-cending aorta walls,which would help us understand the elasticity of great arteries in patients with hypertension.

  2. Avaliação do posicionamento da aorta em pacientes com escoliose idiopática do adolescente

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    Guilherme Augusto Foizer

    2013-01-01

    Full Text Available OBJETIVO: Avaliar o posicionamento da aorta em pacientes com escoliose. MÉTODOS: Foram realizados exames de imagem em pacientes ambulatoriais com escoliose idiopática do adolescente e em um grupo formado por pacientes hígidos, sendo analisados seis parâmetros: comprimento do corpo vertebral, largura, distância aorta-corpo, diâmetro da aorta, distância aorta-canal e ângulo corpo-aorta. RESULTADOS: As curvas variaram entre T3 e L2 com ângulos de Cobb de 46° e 114°. Pela classificação de Lenke os tipos 1AN e 1BN ocorreram em 20% dos casos, além de 1CN, 3BN, 3C+ com 13,3 % e 1B+, 3C- com 6,7 %. As vértebras próximas ao ápice da curva no grupo escoliose apresentam valores superiores às do grupo controle (em T8 com média de 86,93° no grupo escoliose e média 49,07 no grupo controle (p < 0,0001. CONCLUSÃO: Quanto mais próximo do ápice da deformidade, maior a póstero-lateralização da aorta.

  3. Úlcera penetrante de aorta ascendente en un paciente asintomático Penetrating ascending aortic ulcer in an asymptomatic patient

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    A. Bayona

    2012-08-01

    Full Text Available La úlcera penetrante de aorta (UPA es la ulceración de una placa aterosclerótica que afecta a la lámina elástica interna de la aorta, y que puede evolucionar hacia un hematoma de pared o una disección aórtica si se produce el paso de sangre hacia la capa media. A pesar de que se localiza más frecuentemente en la aorta descendente, puede presentar una alta mortalidad en caso de situarse en la aorta ascendente, donde la cirugía está indicada aunque el paciente se encuentre asintomático. Presentamos el caso de un paciente sin sintomatología con úlcera penetrante de aorta ascendente (UPAA ascendente sometido a sustitución de aorta ascendente por una prótesis vascular.Penetrating aortic ulcer (PAU has been defined as an atherosclerotic plaque ulceration that breaks the internal elastic lamina of the aorta, which may progress to a wall hematoma or aortic dissection in case of blood seeping into the middle layer. Although PAU is commonly located in the descending aorta, the involvement of the ascending aorta can be fatal. Therefore, surgery is indicated even in asymptomatic patients presenting an ascending PAU. We report on an asymptomatic patient with ascending PAU referred for replacement of the ascending aorta with a composite prosthetic graft.

  4. Segmental and age differences in the elastin network, collagen, and smooth muscle phenotype in the tunica media of the porcine aorta.

    Science.gov (United States)

    Tonar, Zbyněk; Kubíková, Tereza; Prior, Claudia; Demjén, Erna; Liška, Václav; Králíčková, Milena; Witter, Kirsti

    2015-09-01

    The porcine aorta is often used in studies on morphology, pathology, transplantation surgery, vascular and endovascular surgery, and biomechanics of the large arteries. Using quantitative histology and stereology, we estimated the area fraction of elastin, collagen, alpha-smooth muscle actin, vimentin, and desmin within the tunica media in 123 tissue samples collected from five segments (thoracic ascending aorta; aortic arch; thoracic descending aorta; suprarenal abdominal aorta; and infrarenal abdominal aorta) of porcine aortae from growing domestic pigs (n=25), ranging in age from 0 to 230 days. The descending thoracic aorta had the greatest elastin fraction, which decreased proximally toward the aortic arch as well as distally toward the abdominal aorta. Abdominal aortic segments had the highest fraction of actin, desmin, and vimentin positivity and all of these vascular smooth muscle markers were lower in the thoracic aortic segments. No quantitative differences were found when comparing the suprarenal abdominal segments with the infrarenal abdominal segments. The area fraction of actin within the media was comparable in all age groups and it was proportional to the postnatal growth. Thicker aortic segments had more elastin and collagen with fewer contractile cells. The collagen fraction decreased from ascending aorta and aortic arch toward the descending aorta. By revealing the variability of the quantitative composition of the porcine aorta, the results are suitable for planning experiments with the porcine aorta as a model, i.e. power test analyses and estimating the number of samples necessary to achieving a desirable level of precision. The complete primary morphometric data, in the form of continuous variables, are made publicly available for biomechanical modeling of site-dependent distensibility and compliance of the porcine aorta.

  5. Accuracy of Inferior Vena Cava, Aorta, and Jugular Vein Ultrasonographic Diameters in Identifying Pediatric Dehydration

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    Hamid Kariman

    2015-10-01

    Full Text Available Introduction: Evaluating intravascular volume is an important but complicated matter in management of critically ill patients, especially in children. Although invasive techniques have the ability to accurately estimate the intravascular volume, but they have dangerous side effects. Therefore, the present study was designed with the aim of comparing the diagnostic accuracy of sonographic diameters of inferior vena cava (IVC, aorta, internal jugular vein (IJV, and IVC/aorta ratio in identifying pediatric dehydration in children presented to the emergency department (ED. Methods: The present prospective cross-sectional study was carried out with the aim of determining the diagnostic accuracy of sonographic diameters of IVC, IJV, and aorta, in estimation of dehydration rate for children presented to the ED with mild to moderate dehydration. Their screening performance characteristics, such as area under the ROC curve, sensitivity and specificity, were calculated and used for this purpose. The data were analyzed using STATA 11.0 and 0.05 was considered as significance level. Results: In the end, 54 patients were enrolled in the study (57.4% male, mean age of 4.9 ± 2.7 years. Area under the ROC curve for IVC in diagnosis of moderate dehydration in sagittal and transverse planes were 0.775 (95% CI: 0.65 – 0.91 and 0.8086 (95%CI: 0.96 – 0.93, respectively. In addition, the diameter of aorta in this regard were 0.658 (95%CI: 0.51 – 0.81 for the sagittal and 0.7126 (95% CI: 0.57 – 0.86 for the transverse plane. IJV diameter had an area under the curve of 0.7332 (95% CI: 0.59 – 0.88. Comparing the area under the ROC curves for the studied parameters showed that IVC diameter in the sagittal (p = 0.004 and transverse (p < 0.001 planes is a better index for diagnosis of moderate dehydration. Conclusion: Based on the findings of the present study, it seems that IJV, IVC, and aorta diameters are not very accurate for determining the condition of

  6. Analysis of the thoracic aorta using a semi-automated post processing tool

    Energy Technology Data Exchange (ETDEWEB)

    Entezari, Pegah, E-mail: p-entezari@northwestern.edu [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States); Kino, Aya, E-mail: ayakino@gmail.com [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States); Honarmand, Amir R., E-mail: arhonarmand@yahoo.com [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States); Galizia, Mauricio S., E-mail: maugalizia@yahoo.com.br [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States); Yang, Yan, E-mail: yyang@vitalimages.com [Vital images Inc, Minnetonka, MN (United States); Collins, Jeremy, E-mail: collins@fsm.northwestern.edu [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States); Yaghmai, Vahid, E-mail: vyaghmai@northwestern.edu [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States); Carr, James C., E-mail: jcarr@northwestern.edu [Department of Radiology, Cardiovascular Imaging, Northwestern University, Chicago, IL (United States)

    2013-09-15

    Objective: To evaluates a semi-automated method for Thoracic Aortic Aneurysm (TAA) measurement using ECG-gated Dual Source CT Angiogram (DSCTA). Methods: This retrospective HIPAA compliant study was approved by our IRB. Transaxial maximum diameters of outer wall to outer wall were studied in fifty patients at seven anatomic locations of the thoracic aorta: annulus, sinus, sinotubular junction (STJ), mid ascending aorta (MAA) at the level of right pulmonary artery, proximal aortic arch (PROX) immediately proximal to innominate artery, distal aortic arch (DIST) immediately distal to left subclavian artery, and descending aorta (DESC) at the level of diaphragm. Measurements were performed using a manual method and semi-automated software. All readers repeated their measurements. Inter-method, intra-observer and inter-observer agreements were evaluated according to intraclass correlation coefficient (ICC) and Bland–Altman plot. The number of cases with manual contouring or center line adjustment for the semi-automated method and also the post-processing time for each method were recorded. Results: The mean difference between semi-automated and manual methods was less than 1.3 mm at all seven points. Strong inter-method, inter-observer and intra-observer agreement was recorded at all levels (ICC ≥ 0.9). The maximum rate of manual adjustment of center line and contour was at the level of annulus. The average time for manual post-processing of the aorta was 19 ± 0.3 min, while it took 8.26 ± 2.1 min to do the measurements with the semi-automated tool (Vitrea version 6.0.0.1 software). The center line was edited manually at all levels, with most corrections at the level of annulus (60%), while the contour was adjusted at all levels with highest and lowest number of corrections at the levels of annulus and DESC (75% and 0.07% of the cases), respectively. Conclusion: Compared to the commonly used manual method, semi-automated measurement of vessel dimensions is

  7. Estimation of prenatal aorta intima-media thickness from ultrasound examination

    Science.gov (United States)

    Veronese, E.; Tarroni, G.; Visentin, S.; Cosmi, E.; Linguraru, M. G.; Grisan, E.

    2014-10-01

    Prenatal events such as intrauterine growth restriction and increased cardiovascular risk in later life have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. In order to assess and manage atherosclerosis and cardiovascular disease risk in adults and children, in recent years the measurement of abdominal and carotid artery thickness has gained a growing appeal. Nevertheless, no computer aided method has been proposed for the analysis of prenatal vessels from ultrasound data, yet. To date, these measurements are being performed manually on ultrasound fetal images by skilled practitioners. The aim of the presented study is to introduce an automatic algorithm that identifies abdominal aorta and estimates its diameter and aIMT from routine third trimester ultrasonographic fetal data. The algorithm locates the aorta, then segments it and, by modeling the arterial wall longitudinal sections by means of a gaussian mixture, derives a set of measures of the aorta diameter (aDiam) and of the intima-media thickness (aIMT). After estimating the cardiac cycle, the mean diameter and the aIMT at the end-diastole phase are computed. Considering the aIMT value for each subject, the correlation between automatic and manual end-diastolic aIMT measurements is 0.91 in a range of values 0.44-1.10 mm, corresponding to both normal and pathological conditions. The automatic system yields a mean relative error of 19%, that is similar to the intra-observer variability (14%) and much lower that the inter-observer variability (42%). The correlation between manual and automatic measurements and the small error confirm the ability of the proposed system to reliably estimate aIMT values in prenatal ultrasound sequences, reducing measurement variability and suggesting that it can be used for an automatic assessment of aIMT. Preliminary results have been presented in E Veronese, E Cosmi, S Visentin, E Grisan: 'Semiautomatic estimation

  8. Tratamento cirúrgico dos aneurismas toracoabdominais da aorta Surgical treatment of thoracoabdominal aortic aneurysms

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    Januário M Souza

    1991-04-01

    Full Text Available Foram operados, em nosso Serviço, 161 aneurismas da aorta, sendo 99 por dissecção e 62 por outras causas. Em cinco pacientes, os aneurismas eram de localização toracoabdominal, sendo três por degeneração aterosclerótica e dois por dissecção; três pacientes eram do sexo feminino e a idade variou de 31 a 71 anos. Dois pacientes submeteram-se a aneurismectomia previamente (um da aorta ascendente e outro da porção proximal da aorta torácica. Revascularização miocárdica foi feita em um paciente, 40 dias antes da aneurismectomia. A indicação em todos os pacientes foi dor, causada por compressão do aneurisma, sendo que, em dois, havia insuficiência respiratória associada. Todos os pacientes foram operados através de incisão toracoabdominal e abertura do diafragma. A aorta foi substituída por tubo de Dacron, desde sua porção proximal até sua bifurcação, e as artérias viscerais foram implantadas no tubo. Quatro pacientes foram operados com pinçamento da aorta; um paciente necessitou emprego de circulação extracorpórea e parada circulatória, por impossibilidade de pinçamento da aorta junto à artéria subclávia. Todos os pacientes sobreviveram ao ato cirúrgico, ocorrendo dois óbitos no pós-operatório, um subitamente no 12º dia e outro por coma neurológico secundário a parada cardíaca causada por hipoxia.Five patients have been operated on of thoracoabdominal aortic aneurysms. The mean age was 53 years (range 31-71 and three were women. All the patients were symptomatic, three of them had arteriosclerotic aneurysms, and the other two had dissecting aneurysms. Three patients had been operated on previously. The exposure of aneurysm was made through a thoracoabdominal incision, in four patients clamps were placed above and below the aneurysm and it was incised longitudinally. Bypass between left atrium and left femoral artery with hypothermia and circulatory arrest was used in the other patients, since the

  9. Tratamento cirúrgico da coarctação de aorta pela aortoplastia trapezoidal Surgical treatment of coarctation of the aorta using trapezoidal aortoplasty

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    Jarbas Jakson Dinkhuysen

    2004-01-01

    Full Text Available OBJETIVO: A aortoplastia trapezoidal é uma variante técnica da anastomose término-terminal que, amparada em elementos da geometria, objetiva aumentar o diâmetro da aorta ao nível da sutura reduzida e, consequentemente, a manutenção de gradientes pressóricos residuais ou recorrentes indesejáveis a curto e a longo prazo. MÉTODOS: Após a ressecção da área coarctada e tecido ductal, são confeccionados em cada coto aórtico 3 trapezóides que, ao serem confrontados, criam linha de sutura com aspecto sinusoidal (zigue-zague. Foram operados por esta técnica 33 pacientes, a maioria homens, com idades variando de 3 meses a 36 anos (m 9,5 ± 9,7. RESULTADOS: Não ocorreu mortalidade imediata ou tardia e o tempo de evolução a longo prazo foi de 1,1 a 7,6 anos (m 3,6 ± 3,4. A maioria dos pacientes ficou assintomática com níveis normais de pressão arterial, possibilitando a descontinuação da terapêutica antihipertensiva (pOBJECTIVE: Trapezoidal aortoplasty is a technical variant of end-to-end anastomosis, which, based on elements of geometry, aims at increasing the diameter of the aorta at the level of the suture, therefore reducing the occurrence of residual or recurrent pressure gradients in the short and long run. METHODS: After resecting the coarcted area and ductal tissue, 3 trapezoids are confected in each aortic stump, which, when confronted, create a suture line with a sinusoidal aspect (zigzag. Thirty-three patients underwent surgery with this technique, 22 (66.7% males, with ages ranging from 3 months to 36 years (mean of 9.84 ± 9.69. RESULTS: No immediate or late deaths occurred. Follow-up ranged from 1.1 to 7.6 years (mean of 3.6 ± 3.4. Most patients became asymptomatic with normal blood pressure levels, enabling the discontinuation of antihypertensive therapy (P<0.0001. A significant reduction in the pressure gradients was observed on Doppler echocardiography and during cardiac catheterization (P<0.001. The analysis of

  10. Aortoscopia no tratamento das dissecções agudas da aorta Aortoscopy in the treatment of acute dissecting aneurysms of the aorta

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    Gladyston SOUTO

    1999-07-01

    Full Text Available No período de janeiro a dezembro de 1998 , foram operados 10 pacientes portadores de dissecção aguda da aorta (DA Ao 4 do tipo A e 6 do tipo B. O sexo masculino predominou e a idade dos pacientes variou de 34 a 78 anos. Em todos foram realizadas aortoscopias usando hipotermia profunda com parada circulatória total. Usou-se um gastroscópio, obtendo visão do lume da Ao, sendo que todos os pacientes tinham menos que 15 dias da doença. No tipo A, havia re-entrada abaixo da subclávia esquerda em 2 pacientes e, nos outros 2, na bifurcação das ilíacas. No tipo B, havia re-entrada ao nível das renais em 2 pacientes e, ao nível da bifurcação da Ao e das ilíacas, em 4. Em 2 pacientes do tipo A, a aortoscopia orientou na colocação de uma "Tromba de Elefante" como complemento. Nos outros 2, orientou na inversão do sentido da linha arterial. No tipo B, orientou na perfeita colocação da "Tromba de Elefante" e, em 4 pacientes, utilizamos a aortoscopia como complemento diagnóstico. O tempo utilizado na aortoscopia não alterou a morbimortalidade. Podemos concluir que a aortoscopia é um método de diagnóstico rápido, com boa definição das alterações anatômicas da Ao, permitindo um tratamento efetivo. Nos casos agudos instáveis podemos dispensar alguns exames pré-operatórios para não retardarmos a operação. O diagnóstico da re-entrada nos seguimentos inferiores da Ao ajuda a evitar a dissecção retrógrada. Acreditamos que a aortoscopia poderá, no futuro, ser de grande ajuda no diagnóstico e tratamento das DA Ao, bem como de outras lesões da Ao.From January to December 1998, ten patients with dissecting aneurysms of the Aorta (ADA Ao were operated on, 4 type A and 6 type B. Males predominated and ages ranged from 34 to 78 years. In all of them aortoscopy was performed with deep hypothermia and circulatory arrest. A gastroscope was used with visualization of the aortic lumen and all patients had less than 15 days of disease

  11. Effects of Total Alkaloids in Buxus microphylla Leaves on Aorta Smooth Muscle of Rats and Their Mechanisms

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hui-qin; LIU Yan-yan; LI Yong-wen; LI Li; CUI Zhi-qing

    2012-01-01

    Objective To investigate the effects of total alkaloids in Buxus microphylla leaves (ABML) on isolated rats thoracic aorta rings,and then to explore the possible mechanisms underlying the effects.Methods Thoracic aortas of Wistar rats were isolated,removed,and mounted onto an organ bath.The effects of ABML at different concentration on the contraction of isolated thoracic aorta rings (with and without endothelium) precontracted with KC1 or PE were observed with organ bath technique.Dose-effect curves of CaCl2 were recorded by organ bath technique.The concentration of intracellular Ca2+ ([Ca2+]i) increased by PE,KCI,and caffeine in the presence of ABML was determined using Ca2+ sensitive fluorescence indicator Fura-2/AM loaded thoracic aorta vascular smooth muscle (VSM) cells of rats.Results In aorta rings precontracted with PE and KCI,ABML produced concentrationdependent relaxation in both intact and denuded endothelium ring groups.There was no difference in the inhibition of contraction between the intact and denuded endothelium ring groups at the same concentration.Exposure of isolated thoracic aorta rings to ABML led to a significant reduction in the contracting response induced by CaCI2,and shifted the cumulative concentration-response curves to right.ABML could significantly inhibit the extracellular Ca2+ influx induced by PE and KCI under [Ca2+]0 of 1.5 mmol/L,with inhibitory ratios of 40.2% and 49.9%,respectively.In the case of Ca2+-free,ABML could significantly inhibit the intracellular Ca2+ release induced by PE,with inhibitory ratio of 72.4%.Conclusion ABML relaxes thoracic aorta VSM cells by suppressing influx of extracellular Ca2+ via voltage-dependent Ca2+ channel and receptor-operated Ca2+ channel.

  12. The effects of aneurysm repair using an aortic prosthesis on the electrical parameters of the muscular layer of the abdominal aorta.

    Science.gov (United States)

    Hauzer, W; Czerski, A; Zawadzki, W; Gnus, J; Ratajczak, K; Nowak, M; Janeczek, M; Witkiewicz, W; Niespielak, P

    2014-12-01

    The study was carried out on 10 swine of 20-30 kg body weight. Five animals were assigned to each of 2 groups. An aneurysm of the abdominal aorta was created experimentally in animals from the first and second study group. After 4 weeks, animals from the second group were subject to aneurysm repair using an aortic prosthesis. During the experiment, we measured the myoelectric activity of the muscular layer of the abdominal aorta and aneurysmal lesion with the ultrasonographic technique. Measurements of the aorta and aneurysmal lesion and histopathological analyses were carried out post-mortem. We found a statistically significant decrease in the myoelectric activity of the aorta on the aorta-straight prosthesis interface and a significant decrease in the thickness of the muscular layer of the aorta on the aorta-prosthesis interface. No similar changes were found for experimentally induced aneurysms of the abdominal aorta. A straight prosthesis graft may not be the perfect option in the treatment of abdominal aortic aneurysm, as it contributes to the remodelling of the tissue on the prosthesis-aorta interface. This may result in the relapse of an aneurysm and post-operative complications.

  13. Screening for abdominal aortic aneurysms Rastreamento de aneurismas da aorta abdominal

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    Telmo Pedro Bonamigo

    2003-01-01

    Full Text Available OBJECTIVE AND METHODS: Screening for abdominal aortic aneurysms may be useful to decrease mortality related to rupture. We conducted a study to assess the prevalence of abdominal aortic aneurysms in southern Brazil and to define risk factors associated with high prevalence of this disorder. The screening was conducted using abdominal ultrasound. Three groups were studied: Group 1 - cardiology clinic patients; Group 2 - individuals with severe ischemic disease and previous coronary surgery, or important lesions on cardiac catheterism; Group 3 - individuals without cardiac disease selected from the general population. All individuals were male and older than 54 years of age. The ultrasonographic diagnosis of aneurysm was based on an anteroposterior abdominal aorta diameter of 3 cm, or on an abdominal aorta diameter 0.5 cm greater than that of the supra-renal aorta. RESULTS: A total of 2.281 people were screened for abdominal aortic aneurysms in all groups: Group 1 - 768 individuals, Group 2 - 501 individuals, and Group 3 - 1012 individuals. The prevalence of aneurysms was 4.3%, 6.8% and 1.7%, respectively. Age and cigarette smoking were significantly associated with increased prevalence of aneurysms, as was the diagnosis of peripheral artery disease. DISCUSSION: We concluded that screening may be an important tool to prevent the mortality associated with abdominal aortic aneurysms surgery. Additionally, the cost of screening can be decreased if only individuals presenting significant risk factors, such as coronary and peripheral artery disease, smokers and relatives of aneurysm patients, are examined.OBJETIVO E MÉTODOS: O rastreamento de aneurisma da aorta abdominal infra-renal é importante pois pode diminuir a mortalidade relacionada à ruptura. Realizamos um estudo para definir a prevalência desses aneurismas em diversos segmentos da população em nossa região do Brasil. O rastreamento foi realizado utilizando-se a ecografia de abdômen. Tr

  14. Expression of p-PPARγ in the aging thoracic aorta of spontaneously hypertensive rat and inhibitory effect of rosiglitazone

    Institute of Scientific and Technical Information of China (English)

    Hai-Feng; Yuan; Xiao-Lin; Niu; Deng-Feng; Gao; Guang-Hua; Hao; An-Qi; Song; Jin; Wei

    2014-01-01

    Objective:To investigate the expression of phosphorylated peroxisome proliferators-activated receptor y(p-PPARY) in the aging thoracic aorta of spontaneously hypertensive rat(SHR) and the inhibitory effect of rosiglitazone on the phosphorylation of PPART.Methods:16,32 and 64 week-old Wistar-Kyoto rats(WKY) and SHR were randomly and respectively divided into WKY,SHR and SHR+rosiglitazone group(9 in each group).The rats in SHR+rosiglitazone group were treated with rosiglitazone(5 mg/kg,intragastrically) for 56 d,whereas normal saline was applied in WKY and SHR groups.Systolic blood pressure(SBP)of rats was measured by tail cuff method.Histopathological damage of thoracic aorta was analyzed using Hematoxylin-Eosin(HE) staining.Immunohistochemical staining and western blot were performed to test the level of p-PPARY protein in the thoracic aorta arising from each group.Results:The SBP in 16,32 and 64 week-old SHR were significantly higher as compared with those in matched WKY rats(P<0.05,respectively).HE staining showed increased content of smooth muscle cell,wrinkled lining endothelium and increased thickness of internal elastic lamina in the thoracic aorta of SHR.Immunohistochemical staining and western blot indicated that the levels of p-PPARY in the thoracic aorta arising from SHR were obviously higher than those in the thoracic aorta arising from WKY rats(P<0.05,respectively).Importantly,the high SBP,histopathological abnormalities of the thoracic aorta and elevated p-PPARY expression were prominently abrogated by rosiglitazone treatment in SHR(P<0.05,respectively).Furthermore,the SBP,histopathological abnormalities of the thoracic aorta and p-PPARY expression were positively correlated with age in SHR(P<0.05,respectively).Conclusions:The PPARY phosphorylation was observed in the thoracic aorta of SHR and its expression was increased by the increase of age.Furthermore,rosiglitazone inhibited the PPARY phosphorylation and suppressed vascular aging in SHR.

  15. Chronic cadmium treatment promotes oxidative stress and endothelial damage in isolated rat aorta.

    Directory of Open Access Journals (Sweden)

    Camila C P Almenara

    Full Text Available Cadmium is a highly toxic metal that is present in phosphate fertilizers, and the incidence of cadmium poisoning in the general population has increased, mainly due to cigarette smoking. Once absorbed, cadmium accumulates in the tissues, causing harmful effects including high blood pressure, endothelial damage and oxidative stress. Oxidative stress is known to efficiently produce oxidized low-density lipoprotein and consequently atherosclerosis, mainly in the aorta. However, the mechanisms through which endothelial damage is induced by cadmium have not been elucidated. Thus, the aim of this study was to investigate the effects of this metal in the isolated aorta and the possible role of oxidative stress. Rats received 100 mg.L(-1 cadmium chloride (CdCl2 in the drinking water or distilled water alone for four weeks. The pressor effect of cadmium was followed throughout the exposure period by tail plethysmography. At the end of the fourth week, the blood cadmium content was established, and the vascular reactivity of the isolated aorta to phenylephrine, acetylcholine and sodium nitroprusside was analyzed in the context of endothelium denudation and incubation with L-NAME, apocynin, losartan, enalapril, superoxide dismutase (SOD or catalase. We observed an increased response to phenylephrine in cadmium-treated rats. This increase was abolished by catalase and SOD incubation. Apocynin treatment reduced the phenylephrine response in both treatment groups, but its effect was greater in cadmium-treated rats, and NOX2 expression was greater in the cadmium group. These results suggested that cadmium in blood concentrations similar to those found in occupationally exposed populations is able to stimulate NOX2 expression, contributing to oxidative stress and reducing NO bioavailability, despite enhanced eNOS expression. These findings suggest that cadmium exposure promotes endothelial damage that might contribute to inflammation, vascular injury and the

  16. Intramural haematoma of the thoracic aorta: who's to be alerted the cardiologist or the cardiac surgeon?

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    Papadopoulos Georgios S

    2009-10-01

    Full Text Available Abstract This review article is written so as to present the pathophysiology, the symptomatology and the ways of diagnosis and treatment of a rather rare aortic disease called Intra-Mural Haematoma (IMH. Intramural haematoma is a quite uncommon but potentially lethal aortic disease that can strike as a primary occurrence in hypertensive and atherosclerotic patients to whom there is spontaneous bleeding from vasa vasorum into the aortic wall (media or less frequently, as the evolution of a penetrating atherosclerotic ulcer (PAU. IMH displays a typical of dissection progress, and could be considered as a precursor of classic aortic dissection. IMH enfeebles the aortic wall and may progress to either outward rupture of the aorta or inward disruption of the intima layer, which ultimately results in aortic dissection. Chest and back acute penetrating pain is the most commonly noticed symptom at patients with IMH. Apart from a transesophageal echocardiography (TEE, a tomographic imaging such as a chest computed tomography (CT, a magnetic resonance (MRI and most lately a multy detector computed tomography (MDCT can ensure a quick and accurate diagnosis of IMH. Similar to type A and B aortic dissection, surgery is indicated at patients with type-A IMH, as well as at patients with a persistent and/or recurrent pain. For any other patient (with type-B IMH without an incessant pain and/or without complications, medical treatment is suggested, as applied in the case of aortic dissection. The outcome of IMH in ascending aorta (type A appears favourable after immediate (emergent or urgent surgical intervention, but according to international bibliography patients with IMH of the descending aorta (type B show similar mortality rates to those being subjected to conservative medical or surgical treatment. Endovascular surgery and stent-graft placement is currently indicated in type B IMH.

  17. A practical MRI technique for detecting Abdominal Aorta Aneurism and Peripheral Arterial Disease

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    Aykut Aktas

    2014-12-01

    Full Text Available Aim: Peripheral Arterial Disease(PAD and abdominal aorta aneurysm(AAA are frequent problems in geriatric population. In DSA, CTA or MRA techniques contrast agents has to be used for diagnosis that can be nephrotoxic for elderly patients. Magnetic resonans imaging (MRI is the most powerful, non-ionising radiological diagnostic tool that has the highest soft tissue contrast resolution. The aim of our study was to investigate the effectivity of MRI by the means of detecting the AAA and PAD in comparison with DSA. Material and Method: After getting ethical commitee approvel and informed consent, we have performed Balanced turbo field echo(B-TFE MRI technique without contrast agent in 1.5 Tesla MRI device before DSA examination. The luminal diameters of renal arteries, infrarenal abdominal aorta, iliac and femoral arteries was measured by using Philips DICOM Viewer R2.2 application. The intraclass corelation coefficient and reliability used to check if the techniques could be used for each other and the t-test was used to measure the differences between them. Results: There has been a high relationship between B-TFE and DSA in detecting the pathologies of larger arteries like aorta. In the case of small arterial pathologies, there is relatively lower relationship between BTFE and DSA. Discussion: For the diagnosis of AAA and PAD, DSA is the gold standart technique but it is invasive and patients have radiation exposure. In the follow up of geriatric patients with larger arterial pathologies B-TFE can be used instead of contrast enhanced MRA and invasive DSA.

  18. Morphology of the bicuspid aortic valve and elasticity of the adjacent aorta in children.

    Science.gov (United States)

    Pees, Christiane; Michel-Behnke, Ina

    2012-11-01

    Bicuspid aortic valve (BAV) is a common congenital malformation with the known sequela of ascending aortic dilation. The morphology of the BAV and the elasticity of the adjacent ascending aorta appear to influence the outcome. We prospectively examined 48 pediatric patients with an isolated, native BAV for the morphology and size of the aortic valve, aortic root, sinotubular junction, and ascending aorta and their elasticity indexes. A cohort of 48 matching subjects with tricuspid aortic valves was investigated as controls. A comparison of the aortic valve subtypes showed normal-size aortic dimensions in the tricuspid aortic valves. In contrast, in the BAVs, the ascending aorta and aortic valve itself tended to dilate with age and aortic elasticity deteriorated. In the BAVs, the stiffness was significantly greater (4.43 ± 1.82 vs 3.43 ± 0.81 in the tricuspid aortic valves; p = 0.001). The distensibility indexes decreased inversely in the BAVs (6.57 ± 2.83 vs 7.84 ± 2.04 cm(2) × dynes(-1) × 10(-6), p = 0.013; and 53.5 ± 26.0 versus 64.3 ± 17.9 kPa(-1) × 10(-3), p = 0.020). The anteroposterior-oriented phenotype of BAVs showed significantly stiffer and less distensible elasticity even after correction for congenital valve dysfunction, which was more frequent in the left-right-oriented phenotype. In conclusion, the morphology of the BAV seems to play a major role in the outcome of BAV disease, although the left-right phenotype is more prone to congenital valve dysfunction, the anteroposterior phenotype showed worse elasticity quality.

  19. Vasodilator Activity of the Essential Oil from Aerial Parts of Pectis brevipedunculata and Its Main Constituent Citral in Rat Aorta

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    Gisele Zapata-Sudo

    2013-03-01

    Full Text Available The essential oil of Pectis brevipedunculata (EOPB, a Brazilian ornamental aromatic grass, is characterized by its high content of citral (81.9%: neral 32.7% and geranial 49.2%, limonene (4.7% and α-pinene (3.4%. Vasodilation induced by EOPB and isolated citral was investigated in pre-contracted vascular smooth muscle, using thoracic aorta from Wistar Kyoto (WKY rats which was prepared for isometric tension recording. EOPB promoted intense relaxation of endothelium-intact and denuded aortic rings with the concentration to induce 50% of the maximal relaxation (IC50 of 0.044% ± 0.006% and 0.093% ± 0.015% (p 0.05. In endothelium-intact aorta, EOPB-induced vasorelaxation was significantly reduced by L-NAME, a nitric oxide synthase inhibitor. The vasodilator activity of citral was increased in the KCl-contracted aorta and citral attenuated the contracture elicited by Ca2+ in depolarized aorta. EOPB and citral elicited vasorelaxation on thoracic aorta by affecting the NO/cyclic GMP pathway and the calcium influx through voltage-dependent L-type Ca2+ channels, respectively.

  20. Increased contribution of L-arginine-nitric oxide pathway in aorta of mice lacking the gene for vimentin.

    Science.gov (United States)

    Zhang, J; Henrion, D; Ebrahimian, T; Benessiano, J; Colucci-Guyon, E; Langa, F; Lévy, B I; Boulanger, C M

    2001-10-01

    Experiments were designed to investigate endothelial function in the aorta of mice lacking the gene for the cytoskeleton protein vimentin (vim -/- ). Rings with and without endothelium from wild-type (vim +/+ ), heterozygous (vim +/- ), and homozygous (vim -/- ) mice were suspended in organ chambers to record of changes in isometric tension. During phenylephrine contraction, acetylcholine evoked comparable endothelium-dependent relaxations in the three groups. In the presence of Nomega-nitro-L-arginine, acetylcholine caused endothelium-dependent contractions, which were greater in vim -/- than in vim +/+ and vim +/- aortas. Indomethacin did not affect relaxation to acetylcholine in vim +/+ or in vim +/-, but it significantly increased the maximal response in vim -/- (67 +/- 7 vs. 102 +/- 4%). Response to acetylcholine in vim -/- aortas was not affected by cyclooxygenase type 2 inhibitor NS-398, the thromboxane receptor antagonist SQ-29,548, or superoxide dismutase. Relaxations to sodium nitroprusside were not different between vim +/+ and vim -/- mice and were not affected by cyclooxygenase inhibition. Cyclic guanosine monophosphate levels, which were increased to a comparable level by acetylcholine in vim +/+ and vim -/-, were augmented by indomethacin in vim -/- aortas but not in vim +/+ aortas. Expression of endothelial nitric oxide synthase was not different between vim +/+ and vim -/- preparations. These results suggest that despite comparable endothelium-dependent responses to acetylcholine, endothelial cells from vim -/- mice release a cyclooxygenase product that compensates the augmented contribution of nitric oxide.

  1. High-pitch dual-source CT angiography of the whole aorta without ECG synchronisation: Initial experience

    Energy Technology Data Exchange (ETDEWEB)

    Beeres, Martin; Schell, Boris; Mastragelopoulos, Aristidis; Kerl, Josef Matthias; Gruber-Rouh, Tatjana; Lee, Clara; Siebenhandl, Petra; Bodelle, Boris; Zangos, Stephan; Vogl, Thomas J.; Jacobi, Volkmar; Bauer, Ralf W. [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Herrmann, Eva [Clinic of the Goethe University, Department of Biostatistics, Frankfurt (Germany)

    2012-01-15

    To investigate the feasibility, image quality and radiation dose for high-pitch dual-source CT angiography (CTA) of the whole aorta without ECG synchronisation. Each group of 40 patients underwent CTA either on a 16-slice (group 1) or dual-source CT device with conventional single-source (group 2) or high-pitch mode with a pitch of 3.0 (group 3). The presence of motion or stair-step artefacts of the thoracic aorta was independently assessed by two readers. Subjective and objective scoring of motion and artefacts were significantly reduced in the high-pitch examination protocol (p < 0.05). The imaging length was not significantly different, but the imaging time was significantly (p < 0.001) shorter in the high-pitch group (12.2 vs. 7.4 vs. 1.7 s for groups 1, 2 and 3). The ascending aorta and the coronary ostia were reliably evaluable in all patients of group 3 without motion artefacts as well. High-pitch dual-source CT angiography of the whole aorta is feasible in unselected patients. As a significant advantage over regular pitch protocols, motion-free imaging of the aorta is possible without ECG synchronisation. Thus, this CT mode bears potential to become a standard CT protocol before trans-catheter aortic valve implantation (TAVI). (orig.)

  2. In vitro vasodilatory effect of aqueous leaf extract of Thymus serrulatus on thoracic aorta of Guinea pigs

    Institute of Scientific and Technical Information of China (English)

    Bekesho; Geleta; Mebrahtu; Eyasu; Selamu; Kebamo; Asfaw; Debella; Eyasu; Makonnen; Abiy; Abebe

    2015-01-01

    Objective:To investigate the vasodilatory effecl of Thymus serrulatus(T.serrulatus) aqueous leaf extract on KCl(high K~+.80 mmol/L) induced precontracted isolated thoracic aorta rings on guinea pigs and the role of aorta endothelium on this action.Methods:Guinea pig thoracic aorta was removed and placed in an organ bath containing Krebs-Henseleit solution and aorta contractions were recorded isometrically.Results:The results revealed that T.serrulalus aqueous leaf extract(0.5-5 mg/mL)significantly(P<0.001) reduced KCl-induced contractions of guinea pig thoracic aorta in both intact(n=5) and denuded(n=5) endothelium in a concentration dependent manner,and the vasodilatory effect of the extract on intact endothelium was significantly(P<0.05) higher than that on denuded endothelium.Glibenclamide(10 μmol/L) significantly(P<0.001) increased the vasodilatory effect of extract in intact endothelium as compared to methylene blue(10μmol/L).atropine(10 μmol/L) and indomethacin(10 μmol/L).The effecl was more obvious on intact than that on denuded endothelium.Conclusions:The present findings demonstrate that T.serrulalus aqueous leaf extract has vasodilator)’ activity which might result in antihypertensive effect and its vasodilatory effect is endothelium-dependent.This might support the traditional claim of the plant in hypertensive.

  3. Customized CT angiogram planning for intraoperative transesophageal echography-guided endovascular exclusion of thoracic aorta penetrating ulcer.

    Science.gov (United States)

    Piazza, Michele; Lupia, Mario; Grego, Franco; Antonello, Michele

    2015-04-01

    The technique is demonstrated in a 78-year-old man; the preoperative CT angiogram showed a descending thoracic aorta ulcer of 5.9 cm in maximum diameter and 3.8 cm longitudinal extension. A ZTEG-2P-36-127-PF (Cook Medical) single tubular endograft was planned to be deployed. From the preoperative CT angiogram we planned to land 4.7 cm above the midline of the descending thoracic aorta ulcer and 8.0 cm below. In the operating room, under radioscopic vision the centre of the transesophageal echography probe was used as marker to identify the correspondent midline of the descending thoracic aorta ulcer and a centimeter-sized pigtail catheter in the aorta was used to calculate the desired length above and below the ulcer midline. The endograft was introduced and placed in the desired position compared to the transesophageal echography probe and the catheter; under transesophageal echography vision the graft was finally deployed. The CT angiogram at 1 month showed the correct endograft position, descending thoracic aorta ulcer exclusion with no signs of endoleak. In selected cases, this method allows planning in advance safe stent graft positioning and deployment totally assisted by transesophageal echography, with no risk of periprocedural contrast-related renal failure and reduced radiation exposure for the patient and operators.

  4. The AORTA Architecture: Integrating Organizational Reasoning in Jason

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Dignum, Virginia; Villadsen, Jørgen

    2014-01-01

    the expected behavior of the agents. Agents need to be able to reason about the regulations, so that they can act within the expected boundaries and work towards the objectives of the organization. In this paper, we propose the AORTA architecture for making agents organization-aware. It is designed...... such that it provides organizational reasoning capabilities to agents implemented in existing agent programming languages without being tied to a specific organizational model. We show how it can be integrated in the Jason agent programming language, and discuss how the agents can coordinate their organizational tasks...

  5. "Stent" auto-expansível nas dissecções da aorta tipo B

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    PEREIRA Wagner Michael

    1999-01-01

    Full Text Available O tratamento clínico das dissecções agudas da aorta do tipo B tem mortalidade em torno de 25% menor que a mortalidade cirúrgica. O tratamento cirúrgico das dissecções crônicas também produz uma morbidade e mortalidade elevadas. A utilização de "stents"auto-expansíveis endovasculares pode ser uma nova alternativa no tratamento destas lesões. De abril a dezembro de 1998 foram implantados 15 "stents" endovasculares, 10 em dissecções agudas e 5 em crônicas. A idade dos pacientes variou entre 48 e 75 anos (média=60,53±9,73 anos com 66,6% do sexo masculino. Os pacientes foram submetidos à esternotomia mediana, circulação extracorpórea (CEC com hipotermia profunda (18° - 20°C, parada circulatória total (PCT e perfusão cerebral retrógrada (PCR. A aorta transversa foi incisada e implantado o "stent" na aorta descendente sob auxílio de aortoscopia. Foram analisados os tempos de CEC, pinçamento aórtico, PCT, PCR, reaquecimento, ventilação mecânica, internação, sangramento trans e pós-operatório, reposição sangüínea, gasometria, curva de eventos e sobrevida. A mortalidade hospitalar (30 dias foi de 6,6%; 2 pacientes foram reoperados com 3 e 6 meses após a operação com dissecção da aorta ascendente e aneurisma roto distal ao "stent". Quatorze vêm sendo acompanhados com 1 a 8m de evolução, sendo que 85,7% estão livres de eventos e curva de sobrevida de 93,1%(240 dias. Concluímos que o implante de "stent"intraluminais auto-expansíveis apresentou mortalidade menor na fase aguda da doença (6,6% comparada à nossa experiência anterior com o tratamento clínico (30%. Apesar da amostra ser pequena, o procedimento parece ser promissor e necessita mais acompanhamento.

  6. Penoscrotal hypospadias and coarctation of the aorta with mixed gonadal dysgenesis.

    Science.gov (United States)

    Konrad, D; Sossai, R; Winklehner, H L; Binkert, F; Artan, S; Schärli, A F

    2000-01-01

    A 45,X/46,Xidic(Y)(q11.2) mosaicism was found in a 4-year-old boy. The clinical appearance was characterized by bilateral cryptorchidism, penoscrotal hypospadias, short penis, and coarctation of the aorta. The latter is the only abnormality also seen in Turner syndrome. A biopsy of the gonads revealed normal prepubertal testicular tissue. A chromosome analysis in all boys with penoscrotal, scrotal, or perineal hypospadias and a thorough examination of the heart in children with 45,X/46,XY mosaicism are recommended.

  7. Surgical repair of a pseudoaneurysm of the ascending aorta after aortic valve replacement

    Directory of Open Access Journals (Sweden)

    Almeida Rui Manuel Sequeira de

    2001-01-01

    Full Text Available We report the case of a patient with a pseudoaneurysm of the ascending aortic clinically diagnosed 5 months after surgical replacement of the aortic valve. Diagnosis was confirmed with the aid of two-dimensional echocardiography and helicoidal angiotomography. The corrective surgery, which consisted of a reinforced suture of the communication with the ascending aorta after opening and aspiration of the cavity of the pseudoaneurysm, was successfully performed through a complete sternotomy using extracorporeal circulation, femorofemoral cannulation, and moderate hypothermia, with no aortic clamping.

  8. PET/CT imaging of abdominal aorta with intramural hematomas, penetrating ulcer, and saccular pseudoaneurysm.

    Science.gov (United States)

    Nguyen, Vien X; Nguyen, Ba D

    2014-05-01

    Acute aortic syndromes, encompassing intramural hematoma, penetrating ulcer, and pseudoaneurysm, are best demonstrated by angiographic CT and magnetic resonance imaging. These imaging modalities provide an accurate evaluation and allow timely therapies of these frequently symptomatic lesions, thus reducing their morbidity and mortality. The inflammatory pathogenesis of these acute aortic syndromes may exhibit positive PET findings predictive of prognosis and outcomes of these vascular events. The authors present a case of PET/CT imaging showing asymptomatic intramural hematomas with penetrating ulcer and saccular pseudoaneurysm of the proximal abdominal aorta.

  9. IV DSA in the diagnosis and follow-up of dissection of the thoracic aorta

    Energy Technology Data Exchange (ETDEWEB)

    Hendrickx, P.; Luska, G.; Laas, J.; Haverich, A.

    1986-05-01

    Intravenous DSA was performed in 53 patients with suspected dissection of the thoracic aorta and in 13 patients following surgery for aortic dissection. In 36 patients, the suspected diagnosis could be excluded definitely and, in 14 cases out of 17, a dissection was correctly diagnosed. All 11 type B dissections were correctly diagnosed. Of six type A dissections, only three were adequately demonstrated by IV DSA. In type B dissections, IV DSA is reliable, but in type A dissection with massive aortic insufficiency or pericardial tamponade the findings are not reliable. In all 13 patients who had surgery for dissection, IV DSA proved suitable for showing the anastomosis and progress of the disease.

  10. Experimental myocardial hypertrophy induced by a minimally invasive ascending aorta coarctation

    Directory of Open Access Journals (Sweden)

    Martins A.S.

    2001-01-01

    Full Text Available Ascending aorta coarctation was produced by a minimally invasive technique in rabbits. Animal mortality was 5%. Morphometric and hemodynamic parameters were evaluated. A parabiotically isolated heart model was used to assess the hemodynamic parameters. Left ventricular weight/body weight ratio and muscle area showed clear evidence of hypertrophy when compared to control. The hemodynamic changes in the isolated heart model suggested decreased diastolic and systolic function in the coarcted group. The present model produced hypertrophy with low mortality rates as a result of its less invasive nature.

  11. Intravenous digital subtraction angiography in patients with coarctation of the aorta (stenosis of the aortic isthmus)

    Energy Technology Data Exchange (ETDEWEB)

    Rauber, K.; Kollath, J.

    1985-02-01

    The authors report on 18 patients with stenoses of the aortic isthmus in whom digital subtraction angiography had been carried out. In three patients DSA yielded the primary diagnosis of a postductal stenosis of the aortic isthmus. In all postoperative patients, restenosis of the aorta could either be excluded or confirmed. In three cases with complications after an operation, DSA supplied diagnostic information which was decisive for proceeding further. According to the authors' experience, intravenous DSA can replace conventional angiography in the majority of postoperative controls and in future also in primary diagnosis.

  12. The Perceval S Aortic Valve Implantation in Patients with Porcelain Aorta; is this Ideal Option?

    Science.gov (United States)

    Baikoussis, Nikolaos G; Dedeilias, Panagiotis; Prappa, Efstathia; Argiriou, Michalis

    2017-01-01

    We would like to present in this paper a patient with severe aortic valve stenosis referred to our department for surgical aortic valve replacement. In this patient, it was intraoperatively detected an unexpected heavily calcified porcelain ascending aorta. We present the treatment options in this situation, the difficulties affronted intraoperatively, the significance of the preoperative chest computed tomography scan and the use of the Perceval S aortic valve as ideal bioprosthesis implantation. This is a self-expanding, self-anchoring, and sutureless valve with a wide indication in all patients requiring aortic bioprosthesis. PMID:28074827

  13. Successful staged neonatal repair of tetralogy of Fallot with long-segment hypoplasia of the aorta.

    Science.gov (United States)

    Lu, Jimmy C; Shah, Sanket S; Owens, Sonal T; Dorfman, Adam L; Vedre, Ameeth; Goble, Monica M; Hirsch, Jennifer C; Charpie, John R

    2010-01-01

    We describe an extremely rare combination of tetralogy of Fallot (TOF), right-sided cervical aortic arch with long-segment hypoplasia, and other vascular anomalies. A two-stage surgical approach included aortic arch reconstruction followed by right ventricular muscle bundle division and ventricular septal defect closure a few weeks later. The initial clinical presentation, perioperative course, and imaging studies are presented along with a review of the relevant literature. This is the first report of successful neonatal repair of TOF with long-segment hypoplasia of the aorta.

  14. Pulsatile flow in the aorta of the LVAD supported heart studied using particle image velocimetry

    Science.gov (United States)

    Moyedi, Zahra

    Currently many patients die because of the end-stage heart failure, mainly due to the reduced number of donor heart transplant organs. Studies show that a permanent left ventricular assist device (LVAD), a battery driven pump which is surgically implanted, increased the survival rate of patients with end-stage heart failure and improved considerably their quality of life. The inlet conduit of the LVAD is attached to the left ventricle and the outflow conduit anastomosed to the ascending aorta. The purpose of LVAD support is to help a weakened heart to pump blood to the rest of the body. However LVAD can cause some alterations of the natural blood flow. When your blood comes in contact with something that isn't a natural part of your body blood clots can occur and disrupt blood flow. Aortic valve integrity is vital for optimal support of left ventricular assist LVAD. Due to the existence of high continuous transvalvular pressure on the aortic valve, the opening frequency of the valve is reduced. To prevent the development of aortic insufficiency, aortic valve closure during LVAD implantation has been performed. However, the closed aortic valve reduces wash out of the aortic root, which causes blood stagnation and potential thrombus formation. So for this reason, there is a need to minimize the risks of occurring blood clot, by having more knowledge about the flow structure in the aorta during LVAD use. The current study focuses on measuring the flow field in the aorta of the LVAD assisted heart with two different types of aortic valve (Flat and Finned) using the SDSU cardiac simulator. The pulsatile pump that mimics the natural pulsing action of the heart also added to the system. The flow field is visualized using Particle Image Velocimetry (PIV). Furthermore, The fluid mechanics of aorta has been studied when LVAD conduit attached to two different locations (proximal and distal to the aortic valve) with pump speeds of 8,000 to 10,000 revolutions per minute (RPM

  15. Procedimiento de Bentall en la enfermedad aneurismática de la aorta ascendente: mortalidad hospitalaria

    OpenAIRE

    2010-01-01

    Introducción: La enfermedad aneurismática de la aorta ascendente (EAAA) se caracteriza por su baja frecuencia, comportamiento heterogéneo, riesgo de rotura y disección, que conllevan elevada mortalidad, por lo que la cirugía electiva es fundamental. Se han desarrollado diversos procedimientos quirúrgicos, considerándose la técnica de Bentall el estándar de referencia. Se describe la mortalidad hospitalaria de la EAAA tratada quirúrgicamente mediante el procedimiento de Bentall. Material y mét...

  16. Tubular hypoplasia of the aorta and right atrioventricular valve dysplasia in a Bulldog.

    Science.gov (United States)

    Robinson, Nicholas A; Armíen, Aníbal G

    2010-07-01

    A Bulldog puppy that died at 1 day of age was presented for postmortem evaluation. Macroscopically, there was marked hypoplasia of the ascending, transverse, and proximal segments of the descending thoracic aorta and almost complete secondary thrombosis of the left ventricle causing a functional stenosis of the left atrioventricular valve. Separately, there was right atrioventricular valve dysplasia with secondary dilation of the right atrium. Microscopically, the left ventricular outflow tract was occluded by chondroid metaplasia, fibrosing recanalization of a left-ventricular thrombus, and isolated Purkinje fiber degeneration and necrosis.

  17. Estudio comparativo de tres variantes del ensayo de la membrana corioalantoidea del huevo de la gallina para la evaluación de la irritación ocular

    Directory of Open Access Journals (Sweden)

    G. Murillo

    2003-01-01

    Full Text Available Durante los últimos años se han desarrollado variasalternativas con el objetivo de reemplazar la prueba de irritaciónocular en el conejo. El objetivo de este trabajo fue comparar lautilidad de tres protocolos diferentes de la prueba de la mem-brana corioalantoidea del huevo de gallina, descrita en una basede datos establecida de técnicas de Toxicología in vitro, eva-luando la irritación potencial de diez sustancias químicas y for-mulaciones. Se compararon los datos con aquellos obtenidos enla prueba animal tradicional. Se halló una buena correlación conlos datos del test in vivopara dos de los protocolos usados, enque tres sustancias fueron clasificadas como no irritantes y sietecomo irritantes en alguna magnitud. Sin embargo, se encontra-ron seis falsos negativos con la tercera prueba usada. Se discu-ten posibles causas para estos resultados. De las tres técnicasestudiadas la mejor es la que se basa en la utilización de azul detripano ya que se trata de una técnica más rápida, de más fácilrealización y con un resultado más fiable al evaluar los dañosocasionados en la membrana corioalantoidea de una forma obje-tiva y cuantificable

  18. Correção cirúrgica de aneurismas da aorta torácica por técnica de exclusão Surgical correction of aneurysms of the thoracic aorta using the aneurysmal exclusion technique

    Directory of Open Access Journals (Sweden)

    Bayard Gontijo Filho

    1988-04-01

    Full Text Available São apresentados 14 pacientes portadores de aneurisma da aorta torácica (4 do arco aórtico e 10 da aorta descendente, com importantes complicações pré-operatórias, que foram submetidos a correção cirúrgica através de técnica de exclusão da área aneurismática. Esta exclusão foi realizada através de um desvio extra-anatômico entre a aorta ascendente e a aorta abdominal, associado a ligadura da aorta, acima e abaixo do aneurisma. Em 5 pacientes, esta ligadura foi realizada com uso de suturas mecânicas (stapler. Houve 6 (42,8% óbitos no período pós-operatório, quase todos relacionados a grave condição clínica pré-operatória, em pacientes portadores de discussão aórtica aguda (tipo B. Dos 8 pacientes sobreviventes, 7 encontram-se em controle clínico por período de 6 meses a 4 anos, com boa evolução. Todos demonstraram redução progressiva do aneurisma, após a cirurgia, tendo, em alguns casos, ocorrido desaparecimento completo do mesmo.The authors report their experience with 14 patients who underwent correction of aneurysms of the aortic arch and descending thoracic aorta, utilizing a technique based on aortic exclusion. The approach was accomplished with an ascending abdominal aortic by-pass, and the aneurysm was isolated with a ligature of the aorta above and below it. In 5 patients, this ligature was done with staplers. Six patients died in the immediate post-operative period, mainly from preoperative clinical condition related to acute aortic dissection of the descending thoracic aorta. Severn patients have been followed from 6 months to 4 years and all of them showed a progressive reduction of the aneurysmal sac.

  19. Reação histopatológica da parede da aorta abdominal ao stent não recoberto Histopathological reaction of the abdominal aorta wall to non-covered stents

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    Rubio Bombonato

    2006-06-01

    Full Text Available OBJETIVO: Avaliar a reação histopatológica da parede aorta abdominal, em suínos, no nível das artérias renais, na presença de stent metálico não recoberto. MÉTODO: Foi estudada histopatologicamente a aorta abdominal de 10 suínos, com peso médio de 86,6 quilos e idade média de 6 meses, submetidos a implante de stent metálico posicionado na aorta, no nível das artérias renais, após 100 dias do implante. Os stents foram liberados por auto-expansão com laparotomia. Os cortes histológicos foram realizados nos seguintes locais: 1 transição entre a aorta normal e aorta contendo stent; 2 aorta contendo o stent; 3 porção contendo os óstios das artérias renais, 4 linfonodos periaórticos e, 5 parênquima renal. As lâminas foram coradas pela técnica da hematoxilina e eosina. RESULTADOS: Os achados macroscópicos revelaram: linfonodomegalia periaórtica; espessamento da parede aórtica; artérias lombares e renais pérvias; estrutura anatômica renal normal. Análises microscópicas, próximas aos stents, evidenciaram espessamento da parede vascular, secundário à fibrose intimal e camada média comprometida com fibrose intersticial. Medidas micrométricas da parede aórtica com o stent, comparada à aorta sem o stent, apresentaram aumento da espessura da parede (75,9% por hiperplasia da camada íntima secundária à proliferação de fibroblastos; depósitos de colágeno com infiltrado inflamatório e granulomas do tipo corpo estranho. CONCLUSÃO: O stent de aço inoxidável descoberto, implantado na aorta de suínos, produziu importante reação inflamatória, com fibrose nas camadas média e íntima, evidenciada pelas análises histopatológicas e a sua presença não comprometeu o estado pérvio da aorta e dos ramos lombares e renais.OBJECTIVE: To evaluate the histopathological reaction of the abdominal aorta wall in pigs' renal arteries to the presence of non-covered stainless steel stents. METHODS: The abdominal aorta of

  20. Measurement of turbulence intensity in the center of the canine ascending aorta with a hot-film anemometer.

    Science.gov (United States)

    Yamaguchi, T; Kikkawa, S; Yoshikawa, T; Tanishita, K; Sugawara, M

    1983-05-01

    The blood flow velocity near the central axis of the canine ascending aorta was measured with a hot-film anemometer. The cardiac output and the heart rate were controlled at will by means of an extracorporeal circulation and by atrial pacing. The turbulent component of the blood flow velocity was calculated using an ensemble average technique. Ensemble average turbulent intensity was also calculated to show the time course of turbulence in the aorta. The ratio of the mean turbulence intensity to the time mean sectional average velocity in the aorta was constant in most animals regardless of the changes in fluid mechanical parameters. The correlation between the frequency parameter and the relative mean turbulence intensity was weakly positive. The power spectrum of the turbulence was also calculated.

  1. Scanning electron microscopic study of the effects of pressure on the luminal surface of the rabbit aorta.

    Science.gov (United States)

    Swinehart, P A; Bentley, D L; Kardong, K V

    1976-01-01

    The effects of pressure on the luminal surface of the rabbit aorta were investigated using the scanning electron microscope. The method followed was perfusion under hydrostatic pressure of a section of thoracic aorta, in vitro. The characteristic ridged pattern seen in sections fixed at zero hydrostatic pressure was to a large extent eliminated when fixation occurred at pressures equivalent to those experienced by the aorta at systole or diastole. This study suggests that the spiral ridged pattern is dependent upon the fixation pressure and may not be present in a normally functioning artery. Any attempts to characterize or interpret the appearance of the luminal arterial wall must take into account the effects of pressure.

  2. Thoracic aorta aneurysm repair in a patient with a solitary kidney: Hybrid Surgery as a bailout procedure

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    Chris Bakoyiannis

    2016-11-01

    Full Text Available Thoracic endovascular aortic repair (TEVAR is an emerging treatment option for thoracic aorta aneurysms (TAA. Endovascular access is a challenge. We present a novel TEVAR-technique in a patient with single kidney and a 6.4cm TAA. Attempting to place a sheath through iliac arteries was unsuccessful. The decision to proceed to hybrid-TEVAR was made. The protection of the solitary kidney was achieved through axillo-femoral bypass, followed by an end-to-side anastomosis between the aorta and a bifurcated graft. Through the graft, a stent was introduced in the thoracic aorta. With the use of contrast material, the right position of the graft was confirmed.

  3. Successful Percutaneous Coronary Intervention through a Severely Bent Artificial Ascending Aorta Using the DIO Thrombus Aspiration Catheter

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    Akinori Fujikake

    2016-01-01

    Full Text Available A 66-year-old man was admitted to our institute because of chest pain. He had undergone replacement of the ascending aorta due to aortic dissection 9 years previously. We made a diagnosis of acute coronary syndrome, and coronary artery angiography was performed. Although the right coronary artery was successfully cannulated, a severe bend of the artificial aorta made it very difficult to advance the catheter into the left coronary artery. Ultimately, a DIO thrombus aspiration catheter was used to enter the left coronary artery, and a stent was implanted successfully. The DIO catheter is very useful when the selection of a guiding catheter is complicated, such as in the case of severe vessel tortuosity or a bend of the ascending aorta.

  4. [Thrombotic occlusion of the terminal aorta associated to a renal fusion and pelvic location ("pancake" kidney). First case report].

    Science.gov (United States)

    Martins, Carlos; Moura, Carlos; Almeida, Paulo; Dinis da Gama, A

    2006-01-01

    Coexistence of thrombotic occlusion of the terminal aorta with a "pancake" kidney is reported in 63-year old man, diagnosed by CT-scans and selective angiography, to assess the renal circulation and for surgical planning. Surgical exposure was transperitoneal and revascularization was accomplished through a bifurcation Dacron graft from the supraceliac aorta to both femorals, associated to the renal revascularization, by means of PTFE graft from the prosthesis to the renal artery. The success of procedure was later demonstrated by angio-RM, showing both grafts working in excellent condition. According to an extensive bibliographic review, this seems to be the first case reporting the association of a thrombotic occlusion of the terminal aorta to a "pancake" kidney, thus justifying its presentation and divulgation.

  5. Erosão esternal por aneurisma da aorta. Qual o melhor acesso?

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    Roberto Gomes de CARVALHO

    2001-03-01

    Full Text Available É descrito o caso de um paciente que apresentava erosão esternal ocasionada por aneurisma da aorta ascendente e hemi-arco aórtico proximal. A via de acesso foi toracotomia bilateral uma vez que a erosão era na parte alta do esterno, empregando-se hipotermia profunda e parada circulatória total. Foi interposto enxerto de pericárdio bovino para correção da aorta ascendente e hemi-arco aórtico proximal e outro enxerto entre o tronco braquicefálico e a parede lateral do enxerto de pericárdio bovino. A artéria descendente anterior foi revascularizada por haver oclusão do óstio da artéria coronária esquerda. Após 3 anos da operação o paciente está assintomático.

  6. Erosão esternal por aneurisma da aorta. Qual o melhor acesso?

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    CARVALHO Roberto Gomes de

    2001-01-01

    Full Text Available É descrito o caso de um paciente que apresentava erosão esternal ocasionada por aneurisma da aorta ascendente e hemi-arco aórtico proximal. A via de acesso foi toracotomia bilateral uma vez que a erosão era na parte alta do esterno, empregando-se hipotermia profunda e parada circulatória total. Foi interposto enxerto de pericárdio bovino para correção da aorta ascendente e hemi-arco aórtico proximal e outro enxerto entre o tronco braquicefálico e a parede lateral do enxerto de pericárdio bovino. A artéria descendente anterior foi revascularizada por haver oclusão do óstio da artéria coronária esquerda. Após 3 anos da operação o paciente está assintomático.

  7. Thrombosis of abdominal aorta in congenital afibrinogenemia: case report and review of literature.

    Science.gov (United States)

    Sartori, M T; Teresa, S M; Milan, M; Marta, M; de Bon, E; Emiliano, D B; Fadin, M; Mariangela, F; Pesavento, R; Raffaele, P; Zanon, E; Ezio, Z

    2015-01-01

    Thrombotic events in congenital hypo-afibrinogenemia have been rarely reported, either in association or not with replacement therapy or thrombotic risk factors. We describe clinical findings and management of thrombosis of abdominal aorta with peripheral embolism in a patient with congenital afibrinogenemia. A review of arterial thrombosis in inherited hypo-afibrinogenemia was also performed. The patient with a severe bleeding history requiring prophylaxis with fibrinogen concentrates (FC) was admitted for ischaemia of the 4th right toe. An angio-CT of abdominal aorta showed a thrombosis from the origin of renal arteries to the carrefour with a distal floating part. No thrombotic risk factors were found; a previous traumatic lesion of aortic wall might have triggered the thrombus formation, whereas the role of FC prophylaxis remains uncertain. The patient was successfully treated with FC, enoxaparin followed by fondaparinux, and low-dose aspirin without bleeding or thrombosis recurrence. After 2 years, aortic thrombus was almost completely recovered. Sixteen hypo/afibrinogenemia patients with arterial thrombosis were found in Literature, showing that thrombosis often occurs at a young age, involves large vessels, its recurrence is not unusual, and therapeutic strategy is not defined yet. Our therapeutic approach was effective and also safe, but further studies are needed to improve the knowledge of pathogenesis and the anti-thrombotic management in this peculiar setting.

  8. Schistosomiasis differentially affects vasoconstrictor responses: up-regulation of 5-HT receptor-mediated aorta contraction

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    Suellen D'Arc dos Santos Oliveira

    2011-06-01

    Full Text Available Schistosomiasis, classified by the World Health Organization as a neglected tropical disease, is an intravascular parasitic disease associated to a chronic inflammatory state. Evidence implicating inflammation in vascular dysfunction continues to mount, which, broadly defined, reflects a failure in the control of intracellular Ca2+ and consequently, vascular contraction. Therefore, we measured aorta contraction induced by 5-hydroxytryptamine (5-HT and endothelin-1 (ET-1, two important regulators of vascular contraction. Isometric aortic contractions were determined in control and Schistosoma mansoni-infected mice. In the infected animals, 5-HT induced a 50% higher contraction in relation to controls and we also observed an increased contraction in response to Ca2+ mobilisation from sarcoplasmic reticulum. Nevertheless, Rho kinase inhibition reduced the contraction in response to 5-HT equally in both groups, discarding an increase of the contractile machinery sensitivity to Ca2+. Furthermore, no alteration was observed for contractions induced by ET-1 in both groups. Our data suggest that an immune-vascular interaction occurs in schistosomiasis, altering vascular contraction outside the mesenteric portal system. More importantly, it affects distinct intracellular signalling involved in aorta contraction, in this case increasing 5-HT receptor signalling.

  9. Contraction of rat thoracic aorta strips induced by phorbol 12-myristate 13-acetate

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    Itoh, H.; Lederis, K.

    1987-02-01

    Phorbol 12-myristate 13-acetate (PMA) induced a slow and progressive increase in tension of rat thoracic aorta strips in the presence of extracellular CaS . Complete relaxation could not be obtained in CaS -free buffer containing 1 mM ethyleneglycol-bis(US -aminoethylether)-N,N'-tetraacetic acid (EGTA) and 10 X M PMA. In the absence of extracellular CaS , PMA (10 X M) induced a small but sustained contraction which was not altered by the addition of another 2 mM EGTA and 3 x 10 V M verapamil. Papaverine (10 U M) relaxed the PMA-induced contraction to the base line, but phentolamine (10 V M), cyproheptadine (10 V M), atropine (10 V M) and tetrodotoxine (10 W M) did not change the contraction. CaS -depleted muscle strips, prepared by four repeated applications of 10 X M norepinephrine in CaS -free buffer, were contracted by 10 X M PMA, but at a lower maximum tension than nontreated strips. The action of PMA on rat aorta strips in CaS -free buffer did not require the presence of the adventitial layer or endothelial cells. These results suggest that PMA may induce activation of protein kinase C and smooth muscle contraction in the absence of extracellular CaS , without an increase in myoplasmic CaS .

  10. Vasorelaxant effect of the aqueous extract of Ajuga iva in rat aorta.

    Science.gov (United States)

    El-Hilaly, Jaouad; Lyoussi, Badiaâ; Wibo, Maurice; Morel, Nicole

    2004-07-01

    The aim of the present study was to investigate the ex vivo and in vitro vascular activity of the aqueous extract of Ajuga iva (L.) Schreber (Labiatae) in normotensive Wistar rats. Chronic oral administration of the extract of Ajuga iva did not significantly affect the systolic blood pressure. In aorta isolated from Ajuga iva-treated rats, the contractile response to noradrenaline was depressed compared to the responses obtained in aorta from untreated rats but the endothelium-dependent relaxation evoked by acetylcholine was not affected. In vitro, Ajuga iva extract inhibited the contraction evoked by noradrenaline. The addition of Ajuga iva extract during the plateau phase of noradrenaline-evoked contraction produced a relaxation that was sensitive to N-nitro-L-arginine. After pre-incubation of the artery in the presence of the plant extract, vasorelaxant effect was markedly less pronounced. The endothelium-dependent relaxation induced by acetylcholine was concentration-dependently blunted in the presence of Ajuga iva extract in the bathing solution. This study indicates that the aqueous extract of Ajuga iva possesses NO-mediated and NO-independent vasorelaxing properties in vitro while only the endothelium-independent effect was observed ex vivo.

  11. Dilation of the ascending aorta in Turner syndrome - a prospective cardiovascular magnetic resonance study

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    Pedersen Erik M

    2011-04-01

    Full Text Available Abstract Background The risk of aortic dissection is 100-fold increased in Turner syndrome (TS. Unfortunately, risk stratification is inadequate due to a lack of insight into the natural course of the syndrome-associated aortopathy. Therefore, this study aimed to prospectively assess aortic dimensions in TS. Methods Eighty adult TS patients were examined twice with a mean follow-up of 2.4 ± 0.4 years, and 67 healthy age and gender-matched controls were examined once. Aortic dimensions were measured at nine predefined positions using 3D, non-contrast and free-breathing cardiovascular magnetic resonance. Transthoracic echocardiography and 24-hour ambulatory blood pressure were also performed. Results At baseline, aortic diameters (body surface area indexed were larger at all positions in TS. Aortic dilation was more prevalent at all positions excluding the distal transverse aortic arch. Aortic diameter increased in the aortic sinus, at the sinotubular junction and in the mid-ascending aorta with growth rates of 0.1 - 0.4 mm/year. Aortic diameters at all other positions were unchanged. The bicuspid aortic valve conferred higher aortic sinus growth rates (p Conclusion A general aortopathy is present in TS with enlargement of the ascending aorta, which is accelerated in the presence of a bicuspid aortic valve.

  12. Measurement of streaming potentials of mammalian blood vessels, aorta and vena cava, in vivo.

    Science.gov (United States)

    Sawyer, P N; Himmelfarb, E; Lustrin, I; Ziskind, H

    1966-09-01

    Attempts to measure streaming potentials in large rabbit blood vessels in vivo have been carried out. Streaming potentials, V(89), were measured by the introduction of microelectrodes through the wall of the blood vessel at separations greater than 1 cm. The outputs from these electrodes fed through calomel cells were amplified and recorded directly by using an Electronics for Medicine photorecorder (White Plains, N. Y.). "Effective streaming currents" were determined by running the output through a low impedence galvanometer while simultaneously measuring the resistance of the circuit V(8) were, therefore, calculated from two measurements and compared. Flow through vessels studied was measured using two different electromagnetic flowmeters. The results indicate that V(8) present in both aorta and vena cava are of the order of 5 to 10 mv. By using the Helmholtz-Smoluchowski equation into which flow was reintegrated, the numbers yield zeta potentials approximating 0.1 to 0.4 v in both aorta and vena cava. This number approaches the apparent upper limit for zeta (actually "interfacial potentials") potentials in biological systems. The measured "i.f." potential is considered as the interreaction of several physical and metabolic factors operating at the blood intimal interface. The polarity of the potential suggests that the interface is negative with respect to the blood flowing through the vessel. Interfacial potential and related V(8) are discussed in terms of their possible importance as a mechanism for maintaining vascular homeostasis in the living animal.

  13. Ethanol disrupts the formation of hypochord and dorsal aorta during the development of embryonic zebrafish

    Institute of Scientific and Technical Information of China (English)

    QIAN Linxi; WANG Yuexiang; JIANG Qiu; ZHONG Tao; SONG Houyan

    2005-01-01

    Exposure to ethanol during human embryonic period has severe teratogenic effects on the cardiovascular system. In our study, we demonstrated that ethanol of gradient concentrations can interfere with the establishment of circulatory system in embryonic zebrafish. The effective concentration to cause 50% malformations (EC50) was 182.5 mmol/L. The ethanol pulse exposure experiment displayed that dome stage during embryogenesis is the sensitive time window to ethanol. It is found that 400 mmol/L ethanol pulse exposure can induce circulatory defects in 43% treated embryos. We ruled out the possibility that ethanol can interfere with the process of hematopoiesis in zebrafish. By employing in situ hybridization with endothelial biomarker (Flk-1), we revealed that ethanol disrupts the establishment of trunk axial vasculature, but has no effect on cranial vessels. Combined with the results of semi-thin histological sections, the in situ hybridization experiments with arterial and venous biomarkers (ephrinB2, ephB4) suggested that ethanol mainly interrupts the development of dorsal aorta while has little effect on axial vein. Further study indicated the negative influence of ethanol on the development of hypochord in zebrafish. The consequent lack of vasculogenic factors including Radar and Ang-1 partly explains the defects in formation and integrity of dorsal aorta. These results provide important clues to the study of adverse effects of ethanol on the cardiovascular development in human fetus.

  14. Fluid dynamics of coarctation of the aorta: analytical solution, in vitro validation and in vivo evaluation

    Science.gov (United States)

    Keshavarz-Motamed, Zahra

    2015-11-01

    Coarctation of the aorta (COA) is a congenital heart disease corresponding to a narrowing in the aorta. Cardiac catheterization is considered to be the reference standard for definitive evaluation of COA severity, based on the peak-to-peak trans-coarctation pressure gradient (PtoP TCPG) and instantaneous systolic value of trans-COA pressure gradient (TCPG). However, invasive cardiac catheterization may carry high risks given that undergoing multiple follow-up cardiac catheterizations in patients with COA is common. The objective of this study is to present an analytical description of the COA that estimates PtoP TCPG and TCPG without a need for high risk invasive data collection. Coupled Navier-Stokes and elastic deformation equations were solved analytically to estimate TCPG and PtoP TCPG. The results were validated against data measured in vitro (e.g., 90% COA: TCPG: root mean squared error (RMSE) = 3.93 mmHg; PtoP TCPG: RMSE = 7.9 mmHg). Moreover, the estimated PtoP TCPG resulted from the suggested analytical description was validated using clinical data in twenty patients with COA (maximum RMSE: 8.3 mmHg). Very good correlation and concordance were found between TCPG and PtoP TCPG obtained from the analytical formulation and in vitro and in vivo data. The suggested methodology can be considered as an alternative to cardiac catheterization and can help preventing its risks.

  15. Mild coarctation of the aorta: to touch or not to touch the patient?

    Science.gov (United States)

    Keshavarz-Motamed, Zahra; Randles, Amanda; Rikhtegar Nezami, Farhad; Partida, Ramon; Nakamura, Kenta; Staziaki, Pedro V.; Ghoshhajra, Brian; Bhatt, Ami; Edelman, Elazer R.

    2015-11-01

    Coarctation of the aorta (COA) is an aortic obstruction. A peak-to-peak trans-coarctation pressure gradient (PKdP) of greater than 20 mmHg warns severe COA and the need for interventional/surgical repair. The optimal method and timing of intervention remain uncertain especially for mild COA (PKdP <20 mmHg); even it is unclear if mild COA should be treated at all. Although it was recently suggested that treatment strategies for mild COA may need to be redefined as transcatheter interventions emerge, benefits of such interventions are unclear. We investigated the effects of transcatheter interventions on the aorta and left ventricle (LV) hemodynamics in 11 patients with mild COA using a developed computational fluid dynamics and lumped parameter modeling framework along with particle image velocimetry and clinical measurements. Such interventions can improve aortic hemodynamics to some extent (e.g., time-averaged wall shear stress and kinetic energy were reduced by about 20%). However there is no concomitant effect on the LV hemodynamics (e.g., stroke work and LV pressure were reduced by only less than 4%). Our computational approach can effectively predict clinical conditions. Herein one must question intervention for mild COA, as it has limited utility in reducing myocardial strain.

  16. Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta.

    Science.gov (United States)

    Park, Ji Young; Lee, Seung Jin; Yun, Mi Ran; Seo, Kyo Won; Bae, Sun Sik; Park, June Woo; Lee, You Jin; Shin, Woo Jung; Choi, Young Whan; Kim, Chi Dae

    2007-12-01

    Schisandra chinensis (SC), a member of the Magnoliaceae family, has been used to improve the vascular health for postmenopausal women in Korea. In order to provide some scientific rationales for such effectiveness, this study investigated the vascular effects of gomisin A (GA) from SC. In the endothelium (ED)-intact rings of rat thoracic aorta, GA (1 x 10 (-6) to 3 x 10 (-4) M) caused a concentration-dependent relaxation which was markedly attenuated not only by removal of ED but also by pretreatment with N(G)-nitro- L-arginine (10 (-4) M) or 1 H-[1,2,4]oxadiazol[4,3- a]quinoxalin-1-one (3 x 10 (-5) M). Direct measurement of nitrite, a metabolite of nitric oxide (NO), confirmed that NO production in isolated aorta was increased by GA. In the ED-denuded specimens, the relaxation by GA was not abolished but reduced significantly. The relaxation by GA in ED-denuded aortic rings were clearly inhibited by calyculin A (3 x 10 (-8) M), an inhibitor of MLC phosphatase. Furthermore, the phenylephrine-enhanced phosphorylation ratio of MLC was significantly attenuated by GA. Based on these results, it is suggested that GA induced vascular relaxation by partially activating ED-dependent NO pathway, and partially dephosphorylation of MLC.

  17. Cardiovascular changes in children with coarctation of the aorta treated by endovascular stenting.

    Science.gov (United States)

    Sezer, S S; Narin, N; Ozyurt, A; Onan, S H; Pamukcu, O; Argun, M; Baykan, A; Uzum, K

    2014-06-01

    The aim of this study was to investigate the echocardiographic, biochemical short- and mid-term effects of the stenting procedure on left ventricular function, aortic stiffness, elasticity and systemic hypertension in children with coarctation of the aorta (CoA). Fifteen patients with native or recurrent CoA and 30 healthy controls who were sex and age matched were included in the study. The blood pressure values, echocardiographic measurements, elastic functions of ascending aorta and serum N-Terminal ProBNP (NT-ProBNP) levels were recorded prospectively before and at the first and sixth month after stenting. The mean arterial pressure recorded before stenting was 134.4±16.3 mm Hg; at the sixth month it was 115.5±9.5 mm Hg and in the control group it was 107.3±9.4 mm Hg. Although blood pressure levels were lower compared with the pre-stenting measurements (Pcoarctation by endovascular stenting led to a reduction in the arteriopathy that had already begun before treatment, it was demonstrated that these children did not completely return to normal.

  18. Quantifying turbulent wall shear stress in a subject specific human aorta using large eddy simulation.

    Science.gov (United States)

    Lantz, Jonas; Gårdhagen, Roland; Karlsson, Matts

    2012-10-01

    In this study, large-eddy simulation (LES) is employed to calculate the disturbed flow field and the wall shear stress (WSS) in a subject specific human aorta. Velocity and geometry measurements using magnetic resonance imaging (MRI) are taken as input to the model to provide accurate boundary conditions and to assure the physiological relevance. In total, 50 consecutive cardiac cycles were simulated from which a phase average was computed to get a statistically reliable result. A decomposition similar to Reynolds decomposition is introduced, where the WSS signal is divided into a pulsating part (due to the mass flow rate) and a fluctuating part (originating from the disturbed flow). Oscillatory shear index (OSI) is plotted against time-averaged WSS in a novel way, and locations on the aortic wall where elevated values existed could easily be found. In general, high and oscillating WSS values were found in the vicinity of the branches in the aortic arch, while low and oscillating WSS were present in the inner curvature of the descending aorta. The decomposition of WSS into a pulsating and a fluctuating part increases the understanding of how WSS affects the aortic wall, which enables both qualitative and quantitative comparisons.

  19. Cilostazol inhibits accumulation of triglyceride in aorta and platelet aggregation in cholesterol-fed rabbits.

    Directory of Open Access Journals (Sweden)

    Hideki Ito

    Full Text Available Cilostazol is clinically used for the treatment of ischemic symptoms in patients with chronic peripheral arterial obstruction and for the secondary prevention of brain infarction. Recently, it has been reported that cilostazol has preventive effects on atherogenesis and decreased serum triglyceride in rodent models. There are, however, few reports on the evaluation of cilostazol using atherosclerotic rabbits, which have similar lipid metabolism to humans, and are used for investigating the lipid content in aorta and platelet aggregation under conditions of hyperlipidemia. Therefore, we evaluated the effect of cilostazol on the atherosclerosis and platelet aggregation in rabbits fed a normal diet or a cholesterol-containing diet supplemented with or without cilostazol. We evaluated the effects of cilostazol on the atherogenesis by measuring serum and aortic lipid content, and the lesion area after a 10-week treatment and the effect on platelet aggregation after 1- and 10-week treatment. From the lipid analyses, cilostazol significantly reduced the total cholesterol, triglyceride and phospholipids in serum, and moreover, the triglyceride content in the atherosclerotic aorta. Cilostazol significantly reduced the intimal atherosclerotic area. Platelet aggregation was enhanced in cholesterol-fed rabbits. Cilostazol significantly inhibited the platelet aggregation in rabbits fed both a normal diet and a high cholesterol diet. Cilostazol showed anti-atherosclerotic and anti-platelet effects in cholesterol-fed rabbits possibly due to the improvement of lipid metabolism and the attenuation of platelet activation. The results suggest that cilostazol is useful for prevention and treatment of atherothrombotic diseases with the lipid abnormalities.

  20. Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning.

    Science.gov (United States)

    Patel, Meghna V; Zhu, Jun-Yi; Jiang, Zhiping; Richman, Adam; VanBerkum, Mark F A; Han, Zhe

    2016-06-01

    G-protein signaling is known to be required for cell-cell contacts during the development of the Drosophila dorsal vessel. However, the identity of the G protein-coupled receptor (GPCR) that regulates this signaling pathway activity is unknown. Here we describe the identification of a novel cardiac specific GPCR, called Gia, for "GPCR in aorta". Gia is the only heart-specific GPCR identified in Drosophila to date and it is specifically expressed in cardioblasts that fuse at the dorsal midline to become the aorta. Gia is the only Drosophila gene so far identified for which expression is entirely restricted to cells of the aorta. Deletion of Gia led to a broken-hearted phenotype, characterized by pericardial cells dissociated from cardioblasts and abnormal distribution of cell junction proteins. Both phenotypes were similar to those observed in mutants of the heterotrimeric cardiac G proteins. Lack of Gia also led to defects in the alignment and fusion of cardioblasts in the aorta. Gia forms a protein complex with G-αo47A, the alpha subunit of the heterotrimeric cardiac G proteins and interacts genetically with G-αo47A during cardiac morphogenesis. Our study identified Gia as an essential aorta-specific GPCR that functions upstream of cardiac heterotrimeric G proteins and is required for morphological integrity of the aorta during heart tube formation. These studies lead to a redefinition of the bro phenotype, to encompass morphological integrity of the heart tube as well as cardioblast-pericardial cell spatial interactions.

  1. A case of coarctation of the aorta associated with the patent ductus arteriosus and the persistent left superior vena cava

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yoo Keun [Hanyang University College of Medicine, Seoul (Korea, Republic of)

    1974-10-15

    This is a case report of multiple congenital vascular anomalies in which coarctation of the aorta combined with the patent ductus arteriosus and the persistent left superior vena cava. The patient was a 15 year old girl and congenital heart disease was suspected during infancy. However, she heard the disease incurable, so she had been well with herb medicine until admission in our hospital. By physical examination and roentgenological studies including aortography, the diagnosis of the patent ductus arteriosus was detected and the coarctation of the aorta was suspected. The persistent left superior vena cava was found during surgery and it was proved roentgenologically by venography.

  2. Single coronary artery with bicuspid aortic valve stenosis and aneurysm of the ascending aorta: report of a case.

    Science.gov (United States)

    Ishida, Narihiro; Shimabukuro, Katsuya; Matsuno, Yukihiro; Ogura, Hiroki; Takemura, Hirofumi

    2014-03-01

    A 73-year-old man with a severely stenosed bicuspid valve and an aneurysm of the ascending aorta underwent valve and aortic surgery. Preoperative imaging revealed a single coronary artery arising from the right side of the sinus of Valsalva and a branch that perfused into the left side of the heart to pass through the front of the pulmonary artery. We replaced the aortic valve and ascending aorta, painstakingly avoiding damage to the coronary artery and obstruction of the sole coronary ostium.

  3. A case of Behcet's disease with aneurysms of common carotid arteries and abdominal aorta

    Energy Technology Data Exchange (ETDEWEB)

    Choo, Yeon Myung; Chang, Kee Hyun; Choi, Sung Jae [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1984-06-15

    One case of Behcet's disease with multiple aneurysms in both common carotid arteries and abdominal aorta is presented with brief review of the literatures. A 26-year-old woman had slowly enlarging pulsatile masses in both sides of neck and recurrent ulcerations in oral cavity and genitalia. One day prior to admission, aphasia, right facial nerve palsy and right hemiplegia suddenly developed. Brain CT showed acute infarction in left basal ganglia. Both Carotid Angiography and abdominal Aortography demonstrated multiple aneurysms in both common carotid arteries and abdominal aorta with organizing thrombi and thromboembolism of internal carotid artery.

  4. Dopplersonographic diagnosis of subclavian steal in infants with coarctation of the aorta and interrupted aortic arch. [Comparison with angiocardiographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Deeg, K.H.; Singer, H.

    1989-03-01

    In two newborns with severe coarctation of the aorta and interrupted aortic arch, subclavian-steal was shown by angiocardiography. In both children pulsed doppler recordings were obtained in the cerebral arteries: Normal forward flow during systole and diastole could be shown in the anterior cerebral arteries, both internal carotid arteries, the basilar artery and the right vertebral artery. In the left vertebral artery in both infants a negative flow indicating backflow from the brain could be shown. Pulsed doppler sonography of the flow in the vertebral arteries is a non invasive method for diagnosis of subclavian steal in infants with coarctation of the aorta and interrupted aortic arch.

  5. [Application of a device for determination of the transplant length during operation of the aorta-coronary bypass].

    Science.gov (United States)

    Volkov, A M; Khubulava, G G; Paĭvin, A A; Liubimov, A I; Kravchuk, V N

    2012-01-01

    Determination of the necessary length of the bypass is one of the principal stages of operation of the aorta-coronary bypass. The greatest difficulty of the determination of the bypass length is the first-priority applying of proximal anastomoses. It requires the surgeon to have great experience, the operation to be longer. It also makes it necessary to prepare a conduit of deliberately excessive length. A device is proposed for the determination of the necessary bypass length during operation of aorta-coronary bypass consisting of a crocodile grip with a fixed to it polymer tube.

  6. Lipid emulsion-mediated reversal of toxic-dose aminoamide local anesthetic-induced vasodilation in isolated rat aorta

    OpenAIRE

    Ok, Seong-Ho; Han, Jeong Yeol; Lee, Soo Hee; Shin, Il-Woo; Lee, Heon Keun; Chung, Young-Kyun; Choi, Mun-Jeoung; Sohn, Ju-Tae

    2013-01-01

    Background Intravenous lipid emulsion has been used to treat systemic toxicity of local anesthetics. The goals of this in vitro study were to determine the ability of two lipid emulsions (Intralipid® and Lipofundin® MCT/LCT) to reverse toxic dose local anesthetic-induced vasodilation in isolated rat aortas. Methods Isolated endothelium-denuded aortas were suspended for isometric tension recording. Vasodilation was induced by bupivacaine (3 × 10-4 M), ropivacaine (10-3 M), lidocaine (3 × 10-3 ...

  7. Evaluación de harina de botón de oro en dietas para conejos en etapa de crecimiento Evaluation of gold-bud flour in diets for rabbits in growing stage

    Directory of Open Access Journals (Sweden)

    Victoria E. Quintero P.

    2007-01-01

    Full Text Available En la Universidad Nacional de Colombia sede Palmira (1.000 msnm, 24 °C y precipitación pluvial anual de 1.020 mm se realizó un experimento con 24 conejos destetos Nueva Zelanda blancos (35 días y 900 g de peso promedio, se empleó un modelo estadístico completamente al azar con tres niveles de inclusión en la dieta de harina de botón de oro (T1-15%, T2-30% y T3-45% y un testigo (T4 con concentrado comercial. Las dietas fueron isocalóricas (2.400 kcal e isoproteicas (16%. No se presentaron diferencias significativas (p ‹ 0.05 en consumo de materia seca. Para la ganancia de peso y conversión alimentaria se presentaron diferencias significativas (p ‹ 0.05 con el testigo (27.3 gd-1 y 3.0 respectivamente T4 y T2 emplearon menor número de días para alcanzar 2.000 g (44.3 y 52.1 días respectivamente; T2 presentó la mayor tasa de retorno marginal.At the farm of the Nacional University of Colombia, Palmira (1.000 masl, 24°C and an annual pluvial precipitation of 1.020 mm an experiment was carried out with 24 white New Zealand weaned rabbits (35 days and 900 grams average weight. The statistical design used was a complete random with 3 levels (treatments of diet inclusion in the gold bud flour (T1 - 15%, T2 - 30% y T3 - 45% and a control (T4 with the commercial concentrated. The diets were isocalorics (2.400 kcal and isoproteics (16%. There weren´t any significant differences (P‹0.05 in consumption of dry matter. With respect to the weight gains and nourishing conversion, significant differences were observed (P‹0.05 with the control (27.3 gd-1 y 3.0 respectively. The treatments T4 and T2 used few days to reach 2.000 g (44.3 and 52.1 days respectively. T2 showed the highest rate of marginal return.

  8. Mechanisms of relaxation induced by flavonoid ayanin in isolated aorta rings from Wistar rats

    Directory of Open Access Journals (Sweden)

    Rosalía Carrón

    2010-09-01

    Full Text Available Introduction: This study shows the relaxant effect induced by ayanin in aorta rings from Wistar rats linked to nitric oxide/cyclic-GMP pathway.  This flavonoid is the prevalent compound obtained from Croton schiedeanus Schlecht (Euphorbiaceae, specie used in Colombian folk medicine for the treatment of arterial hypertension. Objectives: To identify possible action mechanisms of vascular relaxation induced by ayanin (quercetin 3,4',7-trimethyl ether. Methodology: Isolated aorta rings from Wistar rats obtained at the Animal House of the University of Salamanca were contracted with KCl (80 mM or phenylephrine (PE, 10-6 M and exposed to ayanin (10-6-10-4 M.  Then, the effect of ayanin was assessed in deendothelized rings contracted with PE and in intact rings contracted with PE previously incubated with: ODQ (10-6 M, L-NAME (10-4 M, L-NAME plus D- and L-arginine (10-4 M, indomethacin (5x10-6 M, dipyridamole (3x10-7 M, glibenclamide (10-6 M, propranolol (10-6 M, verapamil (10-7 M or atropine (3x10-5 M.  In addition, the relaxant effect of acetylcholine (Ach, 10-8-3x10-4 M, and sodium nitroprusside (SNP, 10-9-3x10-5 M was assessed in the presence and absence of ayanin (10-6 M. Results: Ayanin induced a greater concentration-dependent relaxation in vessels contracted with phenylephrine (pEC50: 5.84±0.05, an effect significantly reduced by deendothelization and by both ODQ and L-NAME.  L-arginine was able to reverse the effect of L-NAME.  Indomethacin weakly inhibited ayanin response.  Dipyridamole, glibenclamide, propranolol, verapamil, and atropine did not affect ayanin relaxation.  Ayanin did not have any effect on the relaxation elicited by acetylcholine (ACh, while weakly decreasing the relaxation induced by sodium nitroprusside (SNP. Conclusion: Ayanin induces endothelium-dependent relaxation in the rat aorta mainly related to nitric oxide/cGMP pathway, according to the response observed in the presence of L-NAME, L-arginine and ODQ.

  9. Modelo de regeneración ósea basado en las células troncales del tejido adiposo de conejo: estudio comparativo con el injerto autólogo óseo

    OpenAIRE

    Alvarez Dotu, José Miguel; Junquera Escribano, María Concepción

    2012-01-01

    Las atrofias óseas, tanto las localizadas como la osteoporosis suponen un grave problema de salud pública. Con los tratamientos convencionales apenas se consigue formar hueso nuevo. Mediante la aplicación de técnicas de medicina regenerativa, con la implantación de células con capacidad osteogénica, como son las células troncales mesenquimales, se podría acelerar e incrementar el proceso de regeneración ósea. En este trabajo de investigación se propone un modelo de regeneración ósea, en conej...

  10. Uso de células madre pluripotenciales extraídas de grasa y del plasma rico en plaquetas como potenciadores en sutura meniscal. Estudio en un modelo de menisco de conejo

    OpenAIRE

    2009-01-01

    Las lesiones meniscales son un lesión frecuente en nuestra práctica clínica. El tratamiento más utilizado en la meniscectomía parcial. La meniscectomía parcial o total favorece la aparición de cambios degenerativos precoces en la articulación de la rodilla. Varios estudios han demostrado la capacidad de reparación de lesiones meniscales que se sitúan en zona periférica vascularizada, por contra de las lesiones localizadas en zona avascular que presenta bajas tasas de reparación. Diversos estu...

  11. Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta.

    Science.gov (United States)

    Cheheltani, Rabee; McGoverin, Cushla M; Rao, Jayashree; Vorp, David A; Kiani, Mohammad F; Pleshko, Nancy

    2014-06-21

    Extracellular matrix (ECM) is a key component and regulator of many biological tissues including aorta. Several aortic pathologies are associated with significant changes in the composition of the matrix, especially in the content, quality and type of aortic structural proteins, collagen and elastin. The purpose of this study was to develop an infrared spectroscopic methodology that is comparable to biochemical assays to quantify collagen and elastin in aorta. Enzymatically degraded porcine aorta samples were used as a model of ECM degradation in abdominal aortic aneurysm (AAA). After enzymatic treatment, Fourier transform infrared (FTIR) spectra of the aortic tissue were acquired by an infrared fiber optic probe (IFOP) and FTIR imaging spectroscopy (FT-IRIS). Collagen and elastin content were quantified biochemically and partial least squares (PLS) models were developed to predict collagen and elastin content in aorta based on FTIR spectra. PLS models developed from FT-IRIS spectra were able to predict elastin and collagen content of the samples with strong correlations (RMSE of validation = 8.4% and 11.1% of the range respectively), and IFOP spectra were successfully used to predict elastin content (RMSE = 11.3% of the range). The PLS regression coefficients from the FT-IRIS models were used to map collagen and elastin in tissue sections of degraded porcine aortic tissue as well as a human AAA biopsy tissue, creating a similar map of each component compared to histology. These results support further application of FTIR spectroscopic techniques for evaluation of AAA tissues.

  12. Analysis of axial prestretch in the abdominal aorta with reference to post mortem interval and degree of atherosclerosis.

    Science.gov (United States)

    Horny, Lukas; Adamek, Tomas; Kulvajtova, Marketa

    2014-05-01

    It is a well-known fact that the length of an artery in situ and the length of an excised artery differs. Retraction of blood vessels is usually observed. This prestretch plays an important role in arterial physiology. We have recently determined that the decrease of axial prestretch in the human abdominal aorta is so closely correlated with age that it is suitable for forensic applications (estimation of the age at time of death for cadavers of unknown identity). Since post mortem autolysis may affect the reliability of an estimate based on axial prestretch, the present study aims to detail analysis of the effect of post mortem time. The abdominal aorta is a prominent site of atherosclerotic changes (ATH), which may potentially affect longitudinal prestretch. Thus ATH was also involved in the analysis. Axial prestretch in the human abdominal aorta, post mortem interval (PMI), and the degree of ATH were documented in 365 regular autopsies. The data was first age adjusted to remove any supposed correlation with age. After the age adjustment of the sample, the correlation analysis showed no significant PMI effects on the prestretch in non-putrefied bodies. Analysis of the prestretch variance with respect to ATH suggested that ATH is not a suitable factor to explain the prestretch variability remaining after the age adjustment. It was concluded that, although atherosclerotic plaques may certainly change the biomechanics of arteries, they do not significantly affect the longitudinal prestretch in the human abdominal aorta.

  13. Regional gene expression of LOX-1, VCAM-1, and ICAM-1 in aorta of HIV-1 transgenic rats

    DEFF Research Database (Denmark)

    Hag, Anne Mette Fisker; Kristoffersen, Ulrik Sloth; Pedersen, Sune Folke

    2009-01-01

    was elevated in the HIV-1Tg rats compared to controls, but the ICAM-1 gene expression profile did not show any differences between the groups. CONCLUSIONS/SIGNIFICANCE: HIV-1Tg rats have gene expression patterns indicating endothelial dysfunction and accelerated atherosclerosis in aorta, suggesting that HIV...

  14. Cardiac-synchronized gadolinium-enhanced MR angiography: preliminary experience for the evaluation of the thoracic aorta.

    NARCIS (Netherlands)

    Goldfarb, J.W.; Holland, A.E.; Heijstraten, F.M.J.; Skotnicki, S.H.; Barentsz, J.O.

    2006-01-01

    Gadolinium (Gd)-enhanced three-dimensional breath-hold magnetic resonance cardiac-synchronized angiography was performed in 13 patients suspected or known to have thoracic aortic disease. High-quality angiograms of the ascending/descending thoracic aorta and coronary arteries were obtained with this

  15. Electrocardiographically triggered CT angiography of the whole aorta and coronary arteries with high-pitch dual-source CT

    Institute of Scientific and Technical Information of China (English)

    张楠

    2013-01-01

    Objective To investigate the feasibility of comprehensive assessment of the whole aorta and coronary arteries(CA)simultaneously with high-pitch128-slice dualsource CT ECG-gated FLASH protocol.Methods A totalof 48 consecutive patients with suspected aortic diseases

  16. Phenotypic and functional heterogeneity of macrophages and dendritic cell subsets in the healthy and atherosclerosis-prone aorta.

    Directory of Open Access Journals (Sweden)

    Elena V Galkina

    2012-03-01

    Full Text Available Atherosclerosis continues to be the leading cause of cardiovascular disease. Development of atherosclerosis depends on chronic inflammation in the aorta and multiple immune cells are involved in this process. Importantly, resident macrophages and dendritic cells are present within the healthy aorta, but the functions of these cells remain poorly characterized. Local inflammation within the aortic wall promotes the recruitment of monocytes and dendritic cell precursors to the aorta and micro-environmental factors direct the differentiation of these emigrated cells into multiple subsets of macrophages and dendritic cells. Recent data suggest that several populations of macrophages and dendritic cells can co-exist within the aorta. Although the functions of M1, M2, Mox and M4 macrophages are well characterized in vitro, there is a limited set of data on the role of these populations in atherogenesis in vivo. Recent studies on the origin and the potential role of aortic dendritic cells provide novel insights into the biology of aortic dendritic cell subsets and prospective mechanisms of the immune response in atherosclerosis. This review integrates the results of experiments analyzing heterogeneity of dendritic cells and macrophage subsets in healthy and diseased vessels and briefly discusses the known and potential functions of these cells in atherogenesis.

  17. Coarctation of the Aorta as a Complication of Surgical Ligation of Patent Ductus Arteriosus in a Premature Infant

    Science.gov (United States)

    Qasim, Amna; Jain, Sunil K.; Jiwani, Amyn K.

    2017-01-01

    Surgical ligation of a patent ductus arteriosus (PDA) is a commonly performed procedure. Complications are infrequent and most commonly include recurrent laryngeal nerve injury and rarely ligation of left pulmonary artery. We report a case of accidental ligation of the descending thoracic aorta leading to a clinically significant coarctation. PMID:28386503

  18. Right Aortic Arch with a Retroesophageal Left Subclavian Artery and an Anomalous Origin of the Pulmonary Artery from the Aorta

    Science.gov (United States)

    Jeon, Chang-Seok; Shim, Man-shik; Yang, Ji-Hyuk; Jun, Tae-Gook

    2017-01-01

    We report the case of a newborn with a rare anatomic variation: a right aortic arch with a retroesophageal left subclavian artery and an anomalous origin of the pulmonary artery from the aorta. This variation was diagnosed using echocardiography and computed tomography, and we treated the condition surgically. PMID:28180103

  19. Prosthetic Subclavian-Aortic Bypass as a Safe Surgical Technique for the Coarctation of the Aorta in Adults

    Directory of Open Access Journals (Sweden)

    Ali Refatllari

    2015-12-01

    CONCLUSION: Coarctation of the aorta in adults is treated with optimal early results at our surgical centre. Subclavian-aortic bypass grafting requires less aortic dissection, can be performed with a partially occluding clamp, and does not compromise the spinal cord vascularization.

  20. Use of thallium 201 myocardial imaging to exclude myocardial infarction after dissection in congenital coarctation of the aorta

    Energy Technology Data Exchange (ETDEWEB)

    Halon, D.A.; Weiss, A.T.; Tzivoni, D.; Atlan, H.; Gotsman, M.S.

    1981-10-01

    The use of a mobile gamma camera with thallium 201 myocardial imaging is described to exclude myocardial infarction in a patient admitted to the coronary care unit in shock and with clinical, enzyme, and ECG changes consistent with infarction. The patient suffered from acute aortic dissection associated with congenital coarctation of the aorta. The myocardial scan excluded transmural myocardial injury.

  1. Anesthetic management for laparoscopy surgery in a patient with residual coarctation of aorta and mild aortic stenosis

    Directory of Open Access Journals (Sweden)

    Renu Sinha

    2011-01-01

    Full Text Available Perioperative management of patients with congenital heart disease is a challenge for the anesthesiologist. We present successful anesthetic management for diagnostic laparoscopy and cystectomy for tubo-ovarian mass in a case of residual coarctation of the aorta along with bicuspid aortic valve and mild aortic stenosis.

  2. Implantation of an Andrastent XL in an adult with advanced chronic heart failure due to coarctation of the aorta.

    Science.gov (United States)

    Białkowski, Jacek; Szkutnik, Małgorzata; Fiszer, Roland; Wolny, Tomasz; Knapik, Tomasz; Nowalany-Kozielska, Ewa; Zembala, Marian

    2011-01-01

    We report the case of a 49 year-old-man with congenital coarctation of the aorta (CoA), admitted in a critical clinical condition due to advanced secondary cardiomyopathy and chronic heart failure. An Andrastent XL was implanted successfully in the CoA. The procedure resulted in an almost completely resolved CoA and prompt clinical improvement in the patient.

  3. Phenotypic and functional heterogeneity of macrophages and dendritic cell subsets in the healthy and atherosclerosis-prone aorta.

    Science.gov (United States)

    Butcher, Matthew J; Galkina, Elena V

    2012-01-01

    Atherosclerosis continues to be the leading cause of cardiovascular disease. Development of atherosclerosis depends on chronic inflammation in the aorta and multiple immune cells are involved in this process. Importantly, resident macrophages and dendritic cells (DCs) are present within the healthy aorta, but the functions of these cells remain poorly characterized. Local inflammation within the aortic wall promotes the recruitment of monocytes and DC precursors to the aorta and micro-environmental factors direct the differentiation of these emigrated cells into multiple subsets of macrophages and DCs. Recent data suggest that several populations of macrophages and DCs can co-exist within the aorta. Although the functions of M1, M2, Mox, and M4 macrophages are well characterized in vitro, there is a limited set of data on the role of these populations in atherogenesis in vivo. Recent studies on the origin and the potential role of aortic DCs provide novel insights into the biology of aortic DC subsets and prospective mechanisms of the immune response in atherosclerosis. This review integrates the results of experiments analyzing heterogeneity of DCs and macrophage subsets in healthy and diseased vessels and briefly discusses the known and potential functions of these cells in atherogenesis.

  4. Vascular dysfunctions in the isolated aorta of double-transgenic hypertensive mice developing aortic aneurysm

    DEFF Research Database (Denmark)

    Waeckel, L.; Badier-Commander, C.; Damery, T.

    2015-01-01

    Angiotensin-II and oxidative stress are involved in the genesis of aortic aneurysms, a phenomenon exacerbated by endothelial nitric oxide synthase (eNOS) deletion or uncoupling. The purpose of this work was to study the endothelial function in wild-type C57BL/6 (BL) and transgenic mice expressing...... not affected in BLSL and AR. However, in ARSL, endothelium-dependent relaxations (acetylcholine, UK-14304) were significantly reduced, and this dysfunction was similar in aortae without or with aneurysms. The endothelial impairment was unaffected by catalase, superoxide-dismutase mimetic, radical scavengers......, cyclooxygenase inhibition, or TP-receptor blockade and could not be attributed to sGC oxidation. Thus, ARSL is a severe hypertension model developing aortic aneurysm. A vascular dysfunction, involving both endothelial (reduced role of NO) and smooth muscle cells, precedes aneurysms formation and, paradoxically...

  5. Calcified aneurysm of the abdominal aorta 12 years after umbilical artery catheterization

    Energy Technology Data Exchange (ETDEWEB)

    Blondiaux, Eleonore; Miquel, Julie [Rouen University Hospital Charles Nicolle, Department of Radiology, Rouen (France); Thomas, Pascale; Watelet, Jacques [Rouen University Hospital Charles Nicolle, Department of Vascular Surgery, Rouen (France); Laloum, Denis [Caen University Hospital, Pediatric Intensive Care Unit, Department of Neonatal Medicine, Caen (France); Dacher, Jean-Nicolas [Rouen University Hospital Charles Nicolle, Department of Radiology, Rouen (France); UFR Medecine et Pharmacie, Laboratoire Quant-If, Rouen Cedex 01 (France)

    2008-02-15

    We report a 12-year-old boy who presented with abdominal pain and who was found to have an aneurysm of the abdominal aorta (AAA). The patient was born from a quadruplet pregnancy induced by in vitro fertilization. Postnatal transient respiratory distress required assisted ventilation that had been monitored by two consecutive umbilical arterial catheters (UAC). AAA is a rare condition in childhood. Infection and/or trauma are known to be the most frequent causes. Most of the reported cases have occurred in children in whom a UAC had been placed during the neonatal period. In this patient the delay between UAC placement and diagnosis was considerable. At the time of this report the patient had remained well during a follow-up of 8 years after treatment. (orig.)

  6. [Traumatic section of the thoracic aorta: its repair by direct aortic clamping].

    Science.gov (United States)

    Cairols, M A; Sieyro, F; Miralles, M; Blanes, I; Lozano, P

    1991-01-01

    Traumatic section of descendent aorta, severe complication of a thoracic traumatism, requires an early recognition and restoration because its high mortality rate. Between 1988 and 1990, three patients underwent surgical approach, by direct aortic clamping [correction of clamplaje], at our Service. In two cases, a heart stoppage appeared during the clamping/unclamping [correction of clampaje/desclampaje] maneuvers. One of them had previously electrocardiographic abnormalities, suggestive of heart contusion. Two patients died, one of them during surgical procedure because an irreversible heart stoppage, and the second patient died after 7 days because of a brain hemorrhage. One case presented postoperative paraplegia. Respective rates and literature about the main factors implicated in the diagnosis and treatment of such pathology are reviewed.

  7. Paradoxical Hypertension after Successful Cheatham Platinum Stent Implantation in an Adolescent with Coarctation of the Aorta

    Science.gov (United States)

    Tan, Yin Ling; Chih, Wan-Ling; Wang, Jou-Kou; Chen, Chun-An

    2016-01-01

    Stent implantation using a Cheatham Platinum (CP) stent for coarctation of the aorta (CoA) is a promising treatment alternative to traditional surgical repair. However, there are no earlier reports in the literature focusing on use of this stent in a Taiwanese patient. Herein we report a 16-year-old boy with CoA presenting with heart murmur and exercise intolerance who underwent successful CP stent placement. However, severe hypertension with arterial blood pressure increasing to 207/104 mmHg occurred four hours after stent implantation. There was no abdominal pain, nausea or vomiting. The patient’s hypertension was controlled by intravenous nitroglycerin infusion, followed by an oral antihypertensitve agent for the following 7 days. Experience from this case highlighted the usefulness of CP stent implantation for native CoA, and the importance of early recognition and management of paradoxical hypertension after CoA stenting. PMID:27899866

  8. Hemodynamics of physiological blood flow in the aorta with nonlinear anisotropic heart valve

    Science.gov (United States)

    Sotiropoulos, Fotis; Gilmanov, Anvar; Stolarski, Henryk

    2016-11-01

    The hemodynamic blood flow in cardiovascular system is one of the most important factor, which causing several vascular diseases. We developed a new Curvilinear Immersed Boundary - Finite Element - Fluid Structure Interaction (CURVIB-FE-FSI) method to analyze hemodynamic of pulsatile blood flow in a real aorta with nonlinear anisotropic aortic valve at physiological conditions. Hyperelastic material model, which is more realistic for describing heart valve have been incorporated in the CURVIB-FE-FSI code to simulate interaction of aortic heart valve with pulsatile blood flow. Comparative studies of hemodynamics for linear and nonlinear models of heart valve show drastic differences in blood flow patterns and hence differences of stresses causing impact at leaflets and aortic wall. This work is supported by the Lillehei Heart Institute at the University of Minnesota.

  9. Modelling atherosclerosis by proteomics: Molecular changes in the ascending aortas of cholesterol-fed rabbits.

    Science.gov (United States)

    Xu, Jingshu; Jüllig, Mia; Middleditch, Martin J; Cooper, Garth J S

    2015-09-01

    The cholesterol-fed rabbit is commonly used as a model to study the vascular effects of hypercholesterolemia and resulting atherosclerotic lesions. Here we undertook a proteomic case-control investigation of ascending aortas from male New Zealand White rabbits after 10 weeks on a high-cholesterol (2% w/w) diet (HCD, n = 5) or control diet (n = 5), in order to determine the changes in response to the HCD. Histology confirmed intimal thickening in the HCD group consistent with atherosclerosis, and LC-MS/MS analysis of individually-obtained ascending aortic extracts labelled with isobaric (iTRAQ) tags enabled the identification and quantitation of 453 unique proteins above the 1% false discovery rate threshold. Of 67 proteins showing significant differences in relative abundance (p atherosclerosis. This and additional novel observations merit further investigation as these perturbations may play important and as yet undiscovered roles in the pathogenesis of atherosclerosis in rabbits as well as humans.

  10. Strong correlation between early stage atherosclerosis and electromechanical coupling of aorta

    Science.gov (United States)

    Liu, X. Y.; Yan, F.; Niu, L. L.; Chen, Q. N.; Zheng, H. R.; Li, J. Y.

    2016-03-01

    Atherosclerosis is the underlying cause of cardiovascular diseases that are responsible for many deaths in the world, and the early diagnosis of atherosclerosis is highly desirable. The existing imaging methods, however, are not capable of detecting the early stage of atherosclerosis development due to their limited spatial resolution. Using piezoresponse force microscopy (PFM), we show that the piezoelectric response of an aortic wall increases as atherosclerosis advances, while the stiffness of the aorta shows a less evident correlation with atherosclerosis. Furthermore, we show that there is strong correlation between the coercive electric field necessary to switch the polarity of the artery and the development of atherosclerosis. Thus by measuring the electromechanical coupling of the aortic wall, it is possible to probe atherosclerosis at the early stage of its development, not only improving the spatial resolution by orders of magnitude, but also providing comprehensive quantitative information on the biomechanical properties of the artery.

  11. Nicotine and the effect of antisympathomimetic agents on the aorta of the rabbit.

    Science.gov (United States)

    MILLSON, D R

    1959-06-01

    The responses of strips of rabbit aorta to almost maximal doses of nicotine were less readily antagonized by five antisympathomimetic agents than were comparable responses to noradrenaline. The effect was most marked with dibenamine, ergotamine, and tolazoline: approximately twice the dose of noradrenaline was required to match the test dose of nicotine after treatment with the antagonists. Dose/response curves for nicotine before and after phentolamine 10(-7) indicate that the phenomenon may be reversed with low doses of nicotine and that the release of noradrenaline by nicotine within the tissues is probably a graded response. The pattern of nicotine/phentolamine antagonism in this preparation is consistent with the view that nicotine acts indirectly by releasing a noradrenaline-like substance, and the difficulty found in antagonizing responses to nicotine with antisympathomimetic agents is probably similar to that responsible for failure of atropine to block some parasympathomimetic responses to nicotine.

  12. Automated Detection of Healthy and Diseased Aortae from Images Obtained by Contrast-Enhanced CT Scan

    Directory of Open Access Journals (Sweden)

    Michael Gayhart

    2013-01-01

    Full Text Available Purpose. We developed the next stage of our computer assisted diagnosis (CAD system to aid radiologists in evaluating CT images for aortic disease by removing innocuous images and highlighting signs of aortic disease. Materials and Methods. Segmented data of patient’s contrast-enhanced CT scan was analyzed for aortic dissection and penetrating aortic ulcer (PAU. Aortic dissection was detected by checking for an abnormal shape of the aorta using edge oriented methods. PAU was recognized through abnormally high intensities with interest point operators. Results. The aortic dissection detection process had a sensitivity of 0.8218 and a specificity of 0.9907. The PAU detection process scored a sensitivity of 0.7587 and a specificity of 0.9700. Conclusion. The aortic dissection detection process and the PAU detection process were successful in removing innocuous images, but additional methods are necessary for improving recognition of images with aortic disease.

  13. Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells

    Directory of Open Access Journals (Sweden)

    Droogmans Guy

    2001-05-01

    Full Text Available Abstract Background This study describes the functional interaction between the putative Ca2+ channel TRP4 and the cystic fibrosis transmembrane conductance regulator, CFTR, in mouse aorta endothelium (MAEC. Results MAEC cells express CFTR transcripts as shown by RT-PCR analysis. Application of a phosphorylating cocktail activated a Cl- current with characteristics similar to those of CFTR mediated currents in other cells types (slow activation by cAMP, absence of rectification, block by glibenclamide. The current is present in trp4 +/+ MAEC, but not in trp4 -/- cells, although the expression of CFTR seems unchanged in the trp4 deficient cells as judged from RT-PCR analysis. Conclusions It is concluded that TRP4 is necessary for CFTR activation in endothelium, possibly by providing a scaffold for the formation of functional CFTR channels.

  14. Uterus transplantation model in sheep with heterotopic whole graft and aorta and cava anastomoses.

    Science.gov (United States)

    Gonzalez-Pinto, I M; Tryphonopoulos, P; Avison, D L; Nishida, S; Tekin, A; Santiago, S; Tzakis, A G

    2013-06-01

    Uterine transplantation in the sheep model has been described as a partial or whole orthotopic graft from a living donor with vascular anastomoses. As an alternative to surrogate pregnancy or adoption uterus transplantation might be indicated for cases of infertility of uterine origin. The main complications might be rejection and thrombosis. The objective of this work was to develop a model of whole uterus transplantation that was applicable to the human setting, using grafts obtained from brain-dead donors, and suitable for immunologic and viability follow-up with a reduced risk of thrombosis. Two donors and 1 recipient were operated. The first graft was used for an anatomic study; the second was used for transplantation. The donor operation consisted of an en bloc harvest of the uterus, adnexa, and proximal vagina with the distal aorta and cava. After harvest the donor sheep was humanely killed. In the recipient ewe, heterotopic implantation was performed in the lower abdomen. An End-to-side anastomoses of aorta and cava were performed below the recipient's renal vessels. A cutaneous vaginal stoma was performed in the right lower quadrant. The recipient ewe was humanely killed for an autopsy study. The anatomy of uterine veins of the ewe differs from the human. The uterine and ovarian veins join, forming the utero-ovarian vein, which drains at the confluence of the common iliac to the cava. En bloc harvesting allows for rapid graft preparation, with vascular cuffs easily anastomosed with a low risk of thrombosis. The vaginal stoma seems appropriate to facilitate follow-up and graft biopsy. This approach can be a suitable experimental model applicable to humans using grafts from brain-dead donors.

  15. The role of two-dimensional echocardiography in diagnostics of coarctation of the aorta in newborns

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    Ilisić Tamara

    2015-01-01

    Full Text Available Introduction. Diagnosis of neonatal coarctation of the aorta (CoA still presents a challenge in routine practice because of absence of reliable morphologic and functional parameters for early detection of this congenital heart defect in newborns. Objective. The aim of this study is to identify easy obtainable two-dimensional echocardiographic parameters for detection of the CoA in newborns. Methods. Echocardiographic evaluation was performed in 30 newborns with CoA and 20 healthy neonates (control group. Measurements of the proximal transverse arch (PTA, distal transverse arch (DTA, isthmus, distance between the left common carotid artery (LCCA at the origin of the left subclavian artery (LSA, were obtained by two-dimensional echocardiography. Aortic arch hypoplasia was defined using Mouleart, Karl and Mee criteria, and Z-value. Index 1 was calculated as a ratio of DTA and distance between origins LCCA-LSA, Index 2 was calculated as a ratio of the ascending aorta and the distance between LCCA-LSA origins, and Index 3 was calculated as a ratio of PTA and distance between LCCA-LSA origins. Results. Index 1 was significantly lower in patients with CoA in comparison with control group (0.50 vs. 1.39; p≤0.01. A cutoff point at 0.39, for Index 1, showed a sensitivity of 92% and specificity of 99% for the diagnosis of neonatal CoA, while cut off points at 0.69 and 0.44, for Index 2 and Index 3, showed the highest sensitivity and specificity for the diagnosis of CoA in newborns. Conclusion. By using these echo indexes, two-dimensional echocardiographic aortic arch measurement becomes a simple, reliable noninvasive method for the evaluation of aortic coarctation in newborns and may lead to earlier diagnosis and subsequent surgical correction.

  16. Characteristics of aortic valve dysfunction and ascending aorta dimensions according to bicuspid aortic valve morphology

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Hong Ju [Konkuk University Medical Center, Konkuk University School of Medicine, Department of Cardiovascular Surgery, Seoul (Korea, Republic of); Yonsei University College of Medicine, Department of Cardiovascular Surgery, Seoul (Korea, Republic of); Shin, Je Kyoun; Chee, Hyun Kun; Kim, Jun Suk [Konkuk University Medical Center, Konkuk University School of Medicine, Department of Cardiovascular Surgery, Seoul (Korea, Republic of); Ko, Sung Min [Konkuk University Medical Center, Konkuk University School of Medicine, Department of Radiology, Seoul (Korea, Republic of)

    2015-07-15

    To characterize aortic valve dysfunction and ascending aorta dimensions according to bicuspid aortic valve (BAV) morphology using computed tomography (CT) and surgical findings. We retrospectively enrolled 209 patients with BAVs who underwent transthoracic echocardiography (TTE) and CT. BAVs were classified as anterior-posterior (BAV-AP) or lateral (BAV-LA) orientation of the cusps and divided according to the presence (raphe+) or absence (raphe-) of a raphe. Ascending aortic dimensions were measured by CT at four levels. BAV-AP was present in 129 patients (61.7 %) and raphe+ in 120 (57.4 %). Sixty-nine patients (33.0 %) had aortic regurgitation (AR), 70 (33.5 %) had aortic stenosis (AS), and 58 (27.8 %) had combined AS and AR. AR was more common in patients with BAV-AP and raphe+; AS was more common with BAV-LA and raphe-.Annulus/body surface area and tubular portion/body surface area diameters in patients with BAV-AP (17.1 ± 2.3 mm/m{sup 2} and 24.2 ± 5.3 mm/m{sup 2}, respectively) and raphe+ (17.3 ± 2.2 mm/m{sup 2} and 24.2 ± 5.5 mm/m{sup 2}, respectively) were significantly different from those with BAV-LA (15.8 ± 1.9 mm/m{sup 2} and 26.4 ± 5.5 mm/m{sup 2}, respectively) and raphe- (15.7 ± 1.9 mm/m{sup 2} and 26.2 ± 5.4 mm/m{sup 2}, respectively). The morphological characteristics of BAV might be associated with the type of valvular dysfunction, and degree and location of an ascending aorta dilatation. (orig.)

  17. Calcium antagonism and the vasorelaxation of the rat aorta induced by rotundifolone

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    Guedes D.N.

    2004-01-01

    Full Text Available The vasorelaxing activity of rotundifolone (ROT, a major constituent (63.5% of the essential oil of Mentha x villosa, was tested in male Wistar rats (300-350 g. In isolated rat aortic rings, increasing ROT concentrations (0.3, 1, 10, 100, 300, and 500 µg/ml inhibited the contractile effects of 1 µM phenylephrine and of 80 or 30 mM KCl (IC50 values, reported as means ± SEM = 184 ± 6, 185 ± 3 and 188 ± 19 µg/ml, N = 6, respectively. In aortic rings pre-contracted with 1 µM phenylephrine, the smooth muscle-relaxant activity of ROT was inhibited by removal of the vascular endothelium (IC50 value = 235 ± 7 µg/ml, N = 6. Furthermore, ROT inhibited (pD2 = 6.04, N = 6 the CaCl2-induced contraction in depolarizing medium in a concentration-dependent manner. In Ca2+-free solution, ROT inhibited 1 µM phenylephrine-induced contraction in a concentration-dependent manner and did not modify the phasic contractile response evoked by caffeine (20 mM. In conclusion, in the present study we have shown that ROT produces an endothelium-independent vasorelaxing effect in the rat aorta. The results further indicated that in the rat aorta ROT is able to induce vasorelaxation, at least in part, by inhibiting both: a voltage-dependent Ca² channels, and b intracellular Ca2+ release selectively due to inositol 1,4,5-triphosphate activation. Additional studies are required to elucidate the mechanisms underlying ROT-induced relaxation.

  18. Chronic lead exposure decreases the vascular reactivity of rat aortas: the role of hydrogen peroxide.

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    Karolini Zuqui Nunes

    Full Text Available We investigated whether exposure to small concentrations of lead alters blood pressure and vascular reactivity. Male Wistar rats were sorted randomly into the following two groups: control (Ct and treatment with 100 ppm of lead (Pb, which was added to drinking water, for 30 days. Systolic blood pressure (BP was measured weekly. Following treatment, aortic ring vascular reactivity was assessed. Tissue samples were properly stored for further biochemical investigation. The lead concentration in the blood reached approximately 8 μg/dL. Treatment increased blood pressure and decreased the contractile responses of the aortic rings to phenylephrine (1 nM-100 mM. Following N-nitro-L arginine methyl ester (L-NAME administration, contractile responses increased in both groups but did not differ significantly between them. Lead effects on Rmax were decreased compared to control subjects following superoxide dismutase (SOD administration. Catalase, diethyldithiocarbamic acid (DETCA, and apocynin increased the vasoconstrictor response induced by phenylephrine in the aortas of lead-treated rats but did not increase the vasoconstrictor response in the aortas of untreated rats. Tetraethylammonium (TEA potentiated the vasoconstrictor response induced by phenylephrine in aortic segments in both groups, but these effects were greater in lead-treated rats. The co-incubation of TEA and catalase abolished the vasodilatory effect noted in the lead group. The present study is the first to demonstrate that blood lead concentrations well below the values established by international legislation increased blood pressure and decreased phenylephrine-induced vascular reactivity. The latter effect was associated with oxidative stress, specifically oxidative stress induced via increases in hydrogen peroxide levels and the subsequent effects of hydrogen peroxide on potassium channels.

  19. The evidence for histamine H3 receptor-mediated endothelium-dependent relaxation in isolated rat aorta

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    D. M. Djuric

    1995-01-01

    Full Text Available The presence of histamine H3 receptors was evaluated on the rat aorta endothelium. In the presence of pyrilamine (1 nM, 7 nM, 10 nM or thioperamide (1 nM, 10 nM, 30 nM the concentration–response curve for histamine-induced (0.1 nM − 0.01 mM endothelium-dependent rat aorta relaxation was shifted to the right without significant change of the Emax indicating competitive antagonism by pyrilamine (pA2 = 9.33 ± 0.34, slope = 1.09 ± 0.36 or thioperamide (pA2 =9.31 ± 0.16, slope=0.94 ± 0.10. Cimetidine (1 μM did not influence histamine-induced endothelium-dependent rat aorta relaxation. In the presence of thioperamide (1 nM, 10 nM, 30 nM the concentration–response curve for (Rα-MeHA-induced (0.1 nM − 0.01 mM endothelium-dependent relaxation was shifted to the right without significant change of Emax indicated competitive antagonism by thioperamide (pA2 = 9.21 ± 0.4, slope = 1.03 ± 0.35. Pyrilamine (100 nM or cimetidine (1 μM did not influence (Rα-MeHA-induced endothelium-dependent rat aorta relaxation. These results suggest the presence of a heterogenous population of histamine receptors, H1 and H3, on rat aorta endothelium.

  20. Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats

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    Wenping Li

    2016-01-01

    Full Text Available Objective. Puerarin is a natural flavonoid isolated from the TCM lobed kudzuvine root. This study investigated the effect and mechanisms of puerarin on diabetic aorta in rats. Methods. Streptozotocin- (STZ- induced diabetic rats were administered with puerarin for 3 weeks. Levels of serum insulin (INS, PGE2, endothelin (ET, glycated hemoglobin (GHb, H2O2, and nitric oxide (NO in rats were measured by ELISA and colorimetric assay kits. The aortas were stained with H&E. Moreover, the mRNA expression of ICAM-1, LOX-1, NADPH oxidase 2 (NOX2, and NOX4 and the protein expression of ICAM-1, LOX-1, NF-κB p65, E-selectin, NOX2, and NOX4 in aorta tissues were measured by real-time PCR and Western blot, respectively. The localization of ICAM-1, NF-κB p65, NOX2, and NOX4 in the aorta tissues was also determined through immunohistochemistry. Results. Puerarin treatment exerted no effect on fasting blood glucose levels but significantly reduced the serum levels of INS, GHb, PGE2, ET, H2O2, and NO. In addition, puerarin improved the pathological alterations and inhibited the expression of ICAM-1, LOX-1, NOX2, and NOX4 at both mRNA and protein levels. Puerarin also significantly reduced the number of cells showing positive staining for ICAM-1, NOX2, NOX4, and NF-κB p65. Conclusion. Puerarin demonstrated protective effect on the STZ-induced diabetic rat aorta. The protective mechanisms may include regulation of NF-κB and inhibition of NOX2 and NOX4 followed by inhibition of cell adhesion molecule expression.

  1. Validation and aplication of Bioelectrical Impedance (BIA) method to determine body and carcass composition and nutrient retention of growing rabbits = Validación y aplicación de la técnica de la Impedancia Bioeléctrica (BIA) para determinar la composición corporal, de la canal y la retención de nutrientes de conejos en crecimiento

    OpenAIRE

    Saiz del Barrio, Alejandro

    2016-01-01

    Los objetivos de esta tesis fueron 1) obtener y validar ecuaciones de predicción para determinar in vivo la composición corporal y de la canal de conejos en crecimiento de 25 a 77 días de vida utilizando la técnica de la Impedancia Bioeléctrica (BIA), y 2) evaluar su aplicación para determinar diferencias en la composición corporal y de la canal, así como la retención de nutrientes de animales alimentados con diferentes fuentes y niveles de grasa. El primer estudio se realizó para determinar...

  2. Descrição morfológica dos ramos colaterais viscerais da aorta abdominal do macaco-de-cheiro Morphological description of the collateral visceral branches from abdominal aorta of squirrel monkey

    Directory of Open Access Journals (Sweden)

    Maria Rogéria Menezes da Silva

    2011-01-01

    Full Text Available O Saimiri sciureus é um primata não humano existente na região amazônica e não consta na lista de animais em perigo de extinção, de acordo com o IBAMA. Neste trabalho, sistematizou-se os ramos colaterais viscerais da aorta abdominal de seis animais sendo três machos e três fêmeas, os quais tiveram o sistema circulatório preenchido com látex Neoprene, adicionado de contraste radiográfico. O resultado observado foi que a aorta abdominal emitiu ventralmente, como ramo colateral visceral, a artéria celíaca, que se trifurcou nas artérias gástrica esquerda, hepática e lienal. Os ramos da artéria celíaca promovem a irrigação do estômago, duodeno, fígado, pâncreas e baço. A seguir, a aorta abdominal emitiu a artéria mesentérica cranial, de calibre maior que a artéria celíaca e justaposta caudalmente. A artéria mesentérica cranial emitiu ramos que vascularizaram a parte final do duodeno, pâncreas, jejuno, íleo, ceco, cólon maior e cólon menor. A aorta abdominal emitiu lateralmente as artérias renais direita e esquerda. A artéria adrenal esquerda surgiu como um ramo colateral direto da artéria celíaca e a artéria adrenal direita surgiu da artéria renal direita. A artéria mesentérica caudal foi emitida da superfície ventral da aorta abdominal, logo abaixo das artérias renais. Em L6, a aorta abdominal se bifurcou, dando origem às artérias ilíacas externas direita e esquerda e estas deram origem à artéria ilíaca interna e femoral direita e esquerda. As artérias testiculares ou ováricas tiveram origem na artéria ilíaca interna. A continuidade da aorta abdominal deu origem à artéria sacral mediana e a continuidade desta é chamada de artéria caudal mediana. O estudo da espécie em questão é de suma importância para gerar conhecimentos a respeito dos primatas não humanos existentes em nosso país. Dessa forma, pode-se dizer que o Saimiri sciureus é um importante modelo biológico para o

  3. Análise da correlação entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal Analysis of correlation between pseudoexfoliation syndrome and aneurysm of the abdominal aorta

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    Paulo de Tarso Ponte Pierre Filho

    2004-06-01

    Full Text Available OBJETIVO: Examinar a correlação sugerida entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal. MÉTODOS: Sessenta e cinco pacientes recentemente operados por aneurisma de aorta abdominal e 51 controles com aterosclerose periférica, sem aneurisma, submeteram-se ao exame oftalmológico sob dilatação pupilar para investigar a presença de síndrome de pseudo-exfoliação. RESULTADOS: Não houve diferenças estatisticamente significantes entre a média de idade, distribuição por sexo e raça entre os 2 grupos (p > 0,05. Dois dos 65 pacientes com aneurisma de aorta e um dos 51 controles apresentaram síndrome de pseudo-exfoliação (p = 1,00. CONCLUSÃO: A prevalência de síndrome de pseudo-exfoliação em pacientes operados por aneurisma de aorta abdominal e em pacientes com aterosclerose periférica foi similar. Este achado não confirma a associação proposta entre síndrome de pseudo-exfoliação e aneurisma de aorta abdominal.PURPOSE: To investigate the suggested association between pseudoexfoliation syndrome and aneurysm of the abdominal aorta. METHODS: 65 patients recently operated for abdominal aortic aneurysm and 51 controls with peripheral atherosclerosis, without aneurysm, underwent an ophthalmologic examination under pupillary dilatation to detect the presence of pseudoexfoliation syndrome. RESULTS: There were no significant differences regarding mean age and distribution by gender and race between the groups (p > 0.05. Two of 65 patients with aortic aneurysm and one of 51 controls presented pseudoexfoliation syndrome (p = 1.00. CONCLUSION: The prevalence of pseudoexfoliation syndrome in patients operated for abdominal aortic aneurysm and in patients with peripheral atherosclerosis were similar. This finding does not support the proposed association between pseudoexfoliation syndrome and abdominal aortic aneurysm.

  4. Onze anos de experiência com emprego do anel intraluminal para tratamento das doenças da aorta

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    BERNARDES Rodrigo de Castro

    1999-01-01

    Full Text Available O tratamento cirúrgico das doenças da aorta é geralmente acompanhado de altas taxas de morbimortalidade. O paciente que tem média de idade avançada geralmente é apresentado ao cirurgião em estado grave, com má condição nutricional, muitas vezes com alterações em vários órgãos e sistemas causados pela própria doença aguda. A correção convencional exige técnicas coadjuvantes complexas e agressivas como a circulação extracorpórea prolongada, hipotermia profunda, parada circulatória total além de prolongados tempos de pinçamento de aorta. Na tentativa de reduzir a agressão cirúrgica no paciente já intensamente debilitado pela própria doença, desenvolvemos, em 1988, um anel intraluminal (1, 2 que tem medidas projetadas e experimentadas para facilitar a sua manipulação e anastomose, proporcionando uma diminuição acentuada no tempo de operação, tempo de CEC, tempo de pinçamento de aorta, excluindo muitas vezes a circulação extracorpórea e a hipotermia, obtendo uma anastomose fácil, rápida, segura e hemostática. Entre março de 1988 e janeiro de 1999, 432 pacientes foram submetidos a tratamento cirúrgico de dissecções ou aneurismas da aorta em nosso Serviço. Em 328 pacientes empregamos o anel intraluminal como técnica de anastomose. Usamos 489 anéis. Cento e vinte e cinco pacientes eram portadores de dissecção aguda de aorta do tipo A, 29 eram portadores de dissecção aguda de aorta do tipo B, 81 de aneurisma de aorta ascendente, 8 de aneurisma de arco aórtico, 28 pacientes eram portadores de aneurisma de aorta torácica descendente, 17 eram portadores de aneurisma toracoabdominal e 40 pacientes de aneurisma de aorta abdominal infra-renal. A mortalidade global foi de 13,41%. O seguimento ambulatorial destes pacientes variou de 11 anos a 25 dias. A curva actuarial de sobrevivência em 11 anos mostra 67,3%. Em nenhum caso observamos as complicações descritas na literatura, como embolia, formação de

  5. [Central cannulation of the aorta by Seldinger technique in DeBakey type I acute aortic dissection with malperfusion of internal organs].

    Science.gov (United States)

    Barbukhatti, K O; Belash, S A; Kaleda, V I

    Described herein is a case report concerning the use of central cannulation of the aorta by Seldinger technique for DeBakey type I aortic dissection with the involvement of both femoral arteries and the brachiocephalic trunk, as well as with thrombosis of the false lumen from the level of the ascending aorta. This is followed by a brief review discussing the methods of instrumental control of the cannula position in the true lumen of the aorta, as well as peculiarities of using this technique of cannulation in various clinical situations.

  6. Endomorphins restored the endothelium-dependent relaxation of the rabbit aorta rings exposed to high D-glucose condition via NO-cGMP pathway.

    Science.gov (United States)

    Liu, Jing; Wu, Wei-Min; Che, Juan-Juan; Zhang, Jun; Wang, Rui

    2006-01-01

    Rings of rabbit aorta that were both incubated in a high concentration of D-glucose and contracted submaximally by phenylephrine showed significantly decreased endothelium-dependent relaxations induced by acetylcholine. The cGMP production of aorta rings was also reduced. Treatment with endomorphins (1-1000 nmol/L) restored acetylcholine-induced relaxations of aorta rings incubated in high glucose concentrations and increased the cGMP synthesis. Moreover, this effect of endomorphins on endothelium was antagonized by naloxone, and the increase in the production of cGMP was also blocked.

  7. Evaluation of gold–bud flour in diets for rabbits in growing stage Evaluación de harina de botón de oro en dietas para conejos en etapa de crecimiento

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    Peláez Angelica

    2007-12-01

    Full Text Available At the farm of the Nacional University of Colombia, Palmira (1.000 masl, 24°C and an annual pluvial precipitation of 1.020 mm an experiment was carried out with 24 white New Zealand weaned rabbits (35 days and 900 grams average weight. The statistical design used was a complete random with 3 levels (treatments of diet inclusion in the gold bud flour (T1 – 15%, T2 – 30% y T3 – 45% and a control (T4 with the commercial concentrated. The diets were isocalorics (2.400 kcal and isoproteics (16%. There weren´t any significant differences (P‹0.05 in consumption of dry matter. With respect to the weight gains and nourishing conversion, significant differences were observed (P‹0.05 with the control (27.3 gd–1 y 3.0 respectively. The treatments T4 and T2 used few days to reach 2.000 g (44.3 and 52.1 days respectively. T2 showed the highest rate of marginal return.En la Universidad Nacional de Colombia sede Palmira (1.000 msnm, 24 °C y precipitación pluvial anual de 1.020 mm se realizó un experimento con 24 conejos destetos Nueva Zelanda blancos (35 días y 900 g de peso promedio, se empleó un modelo estadístico completamente al azar con tres niveles de inclusión en la dieta de harina de botón de oro (T1–15%, T2–30% y T3–45% y un testigo (T4 con concentrado comercial. Las dietas fueron isocalóricas (2.400 kcal e isoproteicas (16%. No se presentaron diferencias significativas (p ‹ 0.05 en consumo de materia seca. Para la ganancia de peso y conversión alimentaria se presentaron diferencias significativas (p ‹ 0.05 con el testigo (27.3 gd–1 y 3.0 respectivamente T4 y T2 emplearon menor número de días para alcanzar 2.000 g

  8. Caracterización del consumo de productos cárnicos en una población universitaria de la ciudad de Medellín, Colombia

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    Holmes Rodríguez

    2015-07-01

    Full Text Available Introducción: El estudio de estilos de vida saludable en universitarios es parte de las estrategias institucionales para reducir la prevalencia de sobrepeso y obesidad. Por tal razón, el objetivo de esta investigación fue caracterizar en la población universitaria de la ciudad de Medellín, Colombia, el consumo y el conocimiento referente a la importancia del consumo adecuado de productos cárnicos.Material y Métodos: El tamaño de la muestra fue de 400 estudiantes, seleccionados aleatoriamente de acuerdo con los factores de ponderación: género, nivel socioeconómico y tipo de universidad, teniendo en cuenta un nivel de confiabilidad del 95% y un error máximo permisible del 5%.Resultados: Se encontró que el pollo es la carne preferida por los universitarios, seguido del pescado; la carne de cordero es la de menor preferencia; se encontró mayor consumo en el género masculino (p<0,05 de pescado, conejo y cabra. Con respecto al gusto que poseen los estudiantes por los diferentes cárnicos, se encontró mayor gusto entre los hombres (p<0,05 y en las universidades públicas (p<0,0001. En cuanto a los conocimientos sobre el valor nutricional, las mujeres tienen un mayor nivel que los hombres (p<0,05 y los estudiantes de estrato bajo son los que menos conocen sobre las propiedades de los cárnicos (p<0,05.Conclusiones: Teniendo en cuenta el bajo conocimiento de los universitarios sobre la importancia del consumo de cárnicos, es necesario implementar programas de educación e intervención para mejorar sus hábitos alimenticios.

  9. Potencial del Agua del suelo

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    Bustamante Heliodoro

    1986-12-01

    Full Text Available La energía potencial del agua presenta diferencias de un punto del suelo a otro; esas diferencias son las que originan el movimiento del agua de acuerdo a la tendencia universal de la materia en el sentido de moverse de donde la energía potencial es mayor a donde dicha energía es menor. En el suelo el agua en consecuencia se mueve hacia donde su energía decrece hasta lograr su estado de equilibrio. Se desprende entonces que la cantidad de energía potencial absoluta contenida en el agua, no es importante por sí misma, sino por su relación con la energía en diferentes lugares dentro del suelo. El concepto Potencial de agua del suelo es un criterio para esta energía.

  10. Aorta modeling with the element-based zero-stress state and isogeometric discretization

    Science.gov (United States)

    Takizawa, Kenji; Tezduyar, Tayfun E.; Sasaki, Takafumi

    2017-02-01

    Patient-specific arterial fluid-structure interaction computations, including aorta computations, require an estimation of the zero-stress state (ZSS), because the image-based arterial geometries do not come from a ZSS. We have earlier introduced a method for estimation of the element-based ZSS (EBZSS) in the context of finite element discretization of the arterial wall. The method has three main components. 1. An iterative method, which starts with a calculated initial guess, is used for computing the EBZSS such that when a given pressure load is applied, the image-based target shape is matched. 2. A method for straight-tube segments is used for computing the EBZSS so that we match the given diameter and longitudinal stretch in the target configuration and the "opening angle." 3. An element-based mapping between the artery and straight-tube is extracted from the mapping between the artery and straight-tube segments. This provides the mapping from the arterial configuration to the straight-tube configuration, and from the estimated EBZSS of the straight-tube configuration back to the arterial configuration, to be used as the initial guess for the iterative method that matches the image-based target shape. Here we present the version of the EBZSS estimation method with isogeometric wall discretization. With isogeometric discretization, we can obtain the element-based mapping directly, instead of extracting it from the mapping between the artery and straight-tube segments. That is because all we need for the element-based mapping, including the curvatures, can be obtained within an element. With NURBS basis functions, we may be able to achieve a similar level of accuracy as with the linear basis functions, but using larger-size and much fewer elements. Higher-order NURBS basis functions allow representation of more complex shapes within an element. To show how the new EBZSS estimation method performs, we first present 2D test computations with straight

  11. Aorta modeling with the element-based zero-stress state and isogeometric discretization

    Science.gov (United States)

    Takizawa, Kenji; Tezduyar, Tayfun E.; Sasaki, Takafumi

    2016-11-01

    Patient-specific arterial fluid-structure interaction computations, including aorta computations, require an estimation of the zero-stress state (ZSS), because the image-based arterial geometries do not come from a ZSS. We have earlier introduced a method for estimation of the element-based ZSS (EBZSS) in the context of finite element discretization of the arterial wall. The method has three main components. 1. An iterative method, which starts with a calculated initial guess, is used for computing the EBZSS such that when a given pressure load is applied, the image-based target shape is matched. 2. A method for straight-tube segments is used for computing the EBZSS so that we match the given diameter and longitudinal stretch in the target configuration and the "opening angle." 3. An element-based mapping between the artery and straight-tube is extracted from the mapping between the artery and straight-tube segments. This provides the mapping from the arterial configuration to the straight-tube configuration, and from the estimated EBZSS of the straight-tube configuration back to the arterial configuration, to be used as the initial guess for the iterative method that matches the image-based target shape. Here we present the version of the EBZSS estimation method with isogeometric wall discretization. With isogeometric discretization, we can obtain the element-based mapping directly, instead of extracting it from the mapping between the artery and straight-tube segments. That is because all we need for the element-based mapping, including the curvatures, can be obtained within an element. With NURBS basis functions, we may be able to achieve a similar level of accuracy as with the linear basis functions, but using larger-size and much fewer elements. Higher-order NURBS basis functions allow representation of more complex shapes within an element. To show how the new EBZSS estimation method performs, we first present 2D test computations with straight

  12. Use of ascending-abdominal aorta bypass grafts in the complex coarctation of the aorta%应用升主动脉-腹主动脉搭桥术治疗复杂主动脉缩窄

    Institute of Scientific and Technical Information of China (English)

    马全林

    2013-01-01

    Objective:To study a handy、safe and effective surgical treatment of complex coarctation of the aorta .Method:2 patients with complex coarctation of the aorta underwent ascending -abdominal aorta bypass grafts during general anesthesia and normal tempera-ture.Results:the blood pressure of pectoral limb evidently depress and the blood pressure of pelvic limb satisfactorily raise without neu -roloyic complication .Conclusion:the method is simple and effective ,there is low complication and cost .%目的:探讨手术治疗复杂主动脉缩窄的简便、安全、有效的方法。方法:在全麻和常温下经胸腹正中联合切口行升主动脉-腹主动脉搭桥术。结果:手术治疗3例患者,上肢血压下降明显,下肢血压升高满意,无神经系统和其他严重并发症。结论:该手术显露和操作简单,适应证广,疗效确切,并发症少。

  13. Anestesia para aneurismectomia de aorta abdominal infra-renal: experiência com 104 casos consecutivos no HCFMRP-USP

    OpenAIRE

    Breno José Santiago Bezerra de Lima

    2006-01-01

    Introdução. A morbi-mortalidade durante e após anestesia para aneurismectomia de aorta abdominal é alta, pois esta doença acomete pacientes após a sétima década de vida e que possuem várias doenças concomitantes. Objetivos. Analisar e discutir as condutas anestésicas utilizadas nos períodos pré e intra-operatório no Serviço de Anestesiologia do HCFMRP-USP. Casuística e Método. Foram analisados os prontuários de 104 pacientes submetidos à aneurismectomia de aorta no tocante às condutas utiliza...

  14. Changes in aorta alpha1-adrenoceptor number and affinity during one year of streptozotocin-induced diabetes in rats.

    Science.gov (United States)

    Schulingkamp, Robert J; Aloyo, Vincent; Tallarida, Ronald J; Raffa, Robert B

    2005-04-01

    alpha(1)-Adrenoceptor function and density in isolated thoracic aorta were measured during the course of streptozotocin-induced diabetes in rats. Diabetes was induced by a single tail vein injection of streptozotocin (60 mg/kg) and was verified by four measures (blood glucose level, increase in food intake, increase in water intake, and characteristic weight changes). Diabetes produced a significant increase in isolated aorta sensitivity to alpha(1)-adrenoceptor activation, manifested as a significant (p 0.05) in either agonist (phenylephrine) or antagonist (prazosin) affinities (K(A) and pA(2) values, respectively). These results suggest compensatory mechanisms in receptor number and abnormalities in 2nd messenger transduction and can help direct efforts for improving antihypertensive or other pharmacological therapy for diabetic patients.

  15. Hemoptise e hemotórax como apresentação de ruptura de aorta torácica

    OpenAIRE

    Lima,Márcio Silva Miguel; Vieira, Marcelo Luiz Campos

    2009-01-01

    Dissecção da aorta torácica é doença de grande mortalidade em sua fase inicial, mas pode, em alguns casos, se cronificar. Relatamos caso de paciente com dissecção crônica de aorta tipo B (Stanford), admitido na Emergência com confusão mental, dispnéia e relato de hemoptise importante. O eletrocardiograma mostrava alterações inespecíficas e a radiografia de tórax revelou opacificação do hemitórax esquerdo. O ecocardiograma transtorácico não evidenciou dissecção aórtica, mas demonstrou imagem c...

  16. Dietary saffron reduced the blood pressure and prevented remodeling of the aorta in L-NAME-induced hypertensive rats

    Directory of Open Access Journals (Sweden)

    Zohreh Nasiri

    2015-11-01

    Full Text Available Objective(s:The aim of this study was to investigate the effects of nutritional saffron (Crocus sativus L. stigma hydroalcoholic extract on blood pressure (BP and histology of the aorta in normotensive and hypertensive rats. Materials and Methods:   Saffron (200 mg/kg/day was given orally for 5 weeks to normotensive and hypertensive rats. Hypertension was induced by NG-nitro-L-arginine methyl ester (L-NAME; 40 mg/kg/day administration in drinking water, and BP was measured weekly. Histological examination of the thoracic aorta included staining with hematoxylin and eosin, orcein, and periodic acid Schiff methods. Results:  Saffron had no effect on normotensive rats, but on hypertensive rats, prevented BP elevation form the third week of treatment (P

  17. Difficulties with endograft sizing in a patient with traumatic rupture of the thoracic aorta: the possible influence of hypovolemic shock.

    Science.gov (United States)

    van Prehn, Joffrey; van Herwaarden, Joost A; Muhs, Bart E; Arnofsky, Adam; Moll, Frans L; Verhagen, Hence J M

    2008-06-01

    A patient with traumatic thoracic injury and hypovolemic shock is presented to stress important differences in preoperative and postoperative aortic diameters. The patient had a blood pressure of 80/40 mm Hg. A diagnostic computed tomography angiography revealed a rupture of the thoracic aorta, and a thoracic endograft was sized based on these data. However, the postoperative computed tomography angiography (Riva-Rocci, 164/70 mm Hg) showed an increase in aortic diameters of about 30% at multiple levels. In this patient, with rupture of the thoracic aorta and hypovolemia, the aortic diameter was significantly decreased. This indicates that adequate preoperative sizing for endovascular repair of vascular pathology in patients in shock is complicated.

  18. Cardiovascular effects of simultaneous occlusion of the inferior vena cava and aorta in patients treated with hypoxic abdominal perfusion for chemotherapy

    NARCIS (Netherlands)

    J. Hofland (Johannes); R. Tenbrinck (Robert); M.G.A. van IJken (Marc); C.H.J. van Eijck (Casper); A.M.M. Eggermont (Alexander); W. Erdmann (Wilhelm)

    2002-01-01

    textabstractBACKGROUND: Animal studies suggest less cardiovascular disturbance if the aorta and vena cava are occluded simultaneously. We set out to establish the effects of simultaneous clamping in humans, because oncologists suggested that perfusion for chemotherapy could be done

  19. Coarctation of the aorta. Results of modern imaging techniques in the diagnosis of congential cardiac diseases with special reference to nuclear magnetic resonance (MR). 4. Communication

    Energy Technology Data Exchange (ETDEWEB)

    Bonse, G.; Beck, B.; Gunkel, L.V.; Roeser, N.; Kuehnert, A.; Baum, H.

    1986-12-01

    Demonstration of precise anatomical details in coarctation of the aorta by using MR-tomography and digital subtraction angiography. MR-tomography is without risk concerning ionisating effects and contrast medium.

  20. Use of the frozen elephant trunk technique in complicated chronic dissection with porcelain aorta and visceral arteries originating from different lumens.

    Science.gov (United States)

    Zembala, Michal O; Irimie, Vadim; Urbanski, Paul P

    2016-04-01

    A rare case of aortic arch aneurysm combined with chronic aortic dissection is reported. Because the visceral arteries originated from different, equivalently perfused lumens and the descending aorta was circumferentially calcified (porcelain aorta) limiting the possibilities of anastomosing, careful planning of the surgical strategy was of utmost importance. The complex surgery consisted of ascending and total arch replacement using the 'frozen elephant trunk' technique with Thoraflex™ Hybrid Prosthesis (Vascutek, Terumo, Inchinnan, Scotland); however, before insertion of the stent graft, an angioscopic resection of the dissection membrane in the proximal part of the descending aorta was carried out to ensure a complete expansion of the distal edge of the stent within the entire common lumen of the aorta and unimpaired distal flow in both lumens below the stent graft. The surgery and the postoperative course were uneventful.