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Sample records for ao professor huntington

  1. ENSAIO: HOMENAGEM AO PROFESSOR REINIER ROZESTRATEN

    Directory of Open Access Journals (Sweden)

    Antonio C. R. Tupinambá

    2014-02-01

    Full Text Available Trata-se de uma homenagem póstuma ao Professor Doutor Reinier Rozestraten. O texto apresenta, suscintamente, o percurso acadêmico do nomeado professor, em especial a sua passagem pela Psicologia do Trânsito. Paralelamente discorre sobre sua principal obra na área, que, de certo modo introduz o discurso psicológico sobre o comportamento de trânsito em perspectiva nacional, juntamente com sua preocupação em imprimir um caráter científico ao tema e introduzi-lo no contexto da academia e na sociedade em perspectivas teórica e prática. A obra escolhida é considerada um marco para o estabelecimento teórico da disciplina da psicologia do trânsito no Brasil. A homenagem foi originalmente escrita por ocasião dos cinco anos de falecimento do professor Reinier.

  2. O papel do professor junto ao aluno com Altas Habilidades

    Directory of Open Access Journals (Sweden)

    Andréia Jaqueline Devalle Rech

    2012-03-01

    Full Text Available .Quando se discute a Educação Especial é comum, num primeiro momento, lembrar do aluno que compõe o especial na Educação como aquele com deficiência mental, auditiva, visual ou física. No entanto, assim como essas crianças, também os alunos com altas habilidades necessitam de um atendimento especializado, pois ele também é um sujeito da Educação Especial. Nesse sentido, este artigo apresenta a definição de altas habilidades, baseada na teoria de um pesquisador norte-americano e, como foco principal algumas questões que envolvem o professor de forma mais direta com o aluno com altas habilidades em sala de aula. Entre elas estão: questões sobre a aprendizagem escolar desses alunos, bem como os fatores que fazem parte desse processo, estratégias de ensino e a importância da identificação dos alunos com altas habilidades.Palavras-chave: Educação Especial. Professor. Aluno com Altas Habilidades

  3. Sobre o ódio ao professor Entrevista com Fernando Penna

    Directory of Open Access Journals (Sweden)

    Fernando Penna

    2016-01-01

    Full Text Available Ao tomar a decisão de pautar o tema da violência para compor o dossiê do terceiro número de Movimento – revista eletrônica de educação da Universidade Federal Fluminense –, o Conselho Editorial elencou um grande número de facetas da violência que historicamente se manifestam física e presencialmente no interior e fora do espaço escolar. O fenômeno relativamente recente das redes sociais e o vertiginoso processo de crescimento de trocas de informação, interação e mediação virtual a ele agregado, não apenas ampliou o espectro da violência como contribuiu decisivamente para articular o dentro e o fora da escola. Dentre outros exemplos, talvez o mais comum e antigo é o registro de cenas reais de alunos e alunas brigando nos pátios escolares ou nas redondezas da instituição postadas nas redes sociais, muitas delas viralizadas – para usar o barbarismoda ocasião – por um número sempre crescente de adeptos do bullying escolar. Nos últimos cinco anos, nas redes sociais, o exemplo de articulação da violência dentro-fora da escola que mais chama a atenção é o ódio ao professor, conforme observa o professor Fernando Penna na entrevista que publicamos a seguir. Estudioso da manifestação reivindicatória por uma escola sem ideologia trazida nos últimos anos por setores conservadores e reacionários da sociedade brasileira, Penna busca oferecer na entrevista algumas hipóteses para compreendermos o fenômeno do ódio ao professor, bem como algumas pistas para apreendermos os fundamentos que movem aqueles setores no combate ao que denominam de doutrinação ideológica de esquerda, e, concluindo, observa a urgência da resistência ao assédio moral feito dos conservadores ereacionários, chamando a atenção para a importância da ampliação do conhecimento crítico sobre o tema.

  4. Para superar as prescrições direcionadas ao professor de física

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    Maria P. M. de Almeida

    2009-10-01

    Full Text Available Neste estudo partimos da consideração da relevância da autonomia do professor na organização das relações de ensino de que participa em sala de aula. Como prescrições dirigidas ao professor se opõem à possibilidade de autonomia, buscamos compreender manifestações de caráter prescritivo visando contribuir para a diminuição de sua ocorrência. Para tanto, nos apoiamos numa vertente da análise do discurso para compreender como, em certas condições de produção, prescrições, explicitas ou implícitas, são direcionadas a professores de física da educação básica. Os discursos analisados foram obtidos em periódico, ata de encontro e através de entrevistas e questionário. Todos foram formulados em situações relacionadas com o ensino da física, no Brasil, em diferentes momentos desde a segunda metade do século passado. Entre as considerações que o estudo permite inferir, destacase a contribuição da participação na área de educação em ciências na superação das prescrições.

  5. Professor

    DEFF Research Database (Denmark)

    Hansen, Henrik

    2014-01-01

    DEBAT: Danske bistandskroner skal øge den interregionale handel i Afrika - det skaber vækst i Afrika og indirekte handel med danske virksomheder, mener Henrik Hansen, professor ved Økonomisk Institut på KU.......DEBAT: Danske bistandskroner skal øge den interregionale handel i Afrika - det skaber vækst i Afrika og indirekte handel med danske virksomheder, mener Henrik Hansen, professor ved Økonomisk Institut på KU....

  6. Sobre a atualidade dos tabus com relação aos professores Taboos against teachers today

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    Antonio A. S. Zuin

    2003-08-01

    Full Text Available Este texto tem como objetivo argumentar que as atuais representações aversivas dos alunos com relação aos seus mestres, os chamados tabus, são decorrentes da violência simbólica que o professor exerce sobre o aluno, com ênfase na universidade. E se a atitude violenta causa inicialmente uma sensação de mal-estar, logo é identificada como algo "inerente" ao processo de ensino-aprendizagem. Tal violência torna-se valorizada tanto pelos professores quanto pelos alunos que se identificam com o professor na figura do agressor, sendo que tais alunos procuram encontrar oportunidades para poder se desforrar do ressentimento que foi engendrado nas relações cotidianas com seus mestres.This paper intends to argue that the current averse representations students have of their teachers, the so called taboos, follow from the symbolic violence teachers exert on them, mainly in the university. If this violent attitude initially causes a sensation of discomfort, it is soon identified as something "inherent" to the teaching and learning process. Therefore, it is often highly prized by teachers and by the students who identify themselves with the professor as an aggressor, while these students look for opportunities to let go of the resentment generated by their daily relationships to their masters.

  7. O papel da instituição para escolher, acolher e acompanhar ao professor universitário

    OpenAIRE

    da Silva Marques Ferreira, Maria de Lourdes

    2011-01-01

    Objective. To analyze the role of the institution in choosing, receiving and chaperone professors. Methodology. Qualitative study, which body analysis was composed of 32 participations in a thematic forum of a group of nine health professionals. Results. After professor hiring it is necessary to receive and chaperone him. Professors with longer time in the institution represent a more important role in the admission of the new professor. Chaperone process is an opportunity to change and redef...

  8. The progress of Chinese burn medicine from the Third Military Medical University-in memory of its pioneer, Professor Li Ao.

    Science.gov (United States)

    Li, Haisheng; Zhou, Junyi; Peng, Yizhi; Zhang, Jiaping; Peng, Xi; Luo, Qizhi; Yuan, Zhiqiang; Yan, Hong; Peng, Daizhi; He, Weifeng; Wang, Fengjun; Liang, Guangping; Huang, Yuesheng; Wu, Jun; Luo, Gaoxing

    2017-01-01

    Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. The epidemiology and outcomes of admitted burn patients since 1958 were reviewed. Furthermore, main achievements of basic and clinical research for the past roughly 60 years were presented. These achievements mainly included the Chinese Rule of Nine, fluid resuscitation protocol, experience in inhalation injury, wound treatment strategies, prevention and treatment of burn infections, nutrition therapy, organ support therapies, and rehabilitation. The progress shaped and enriched modern Chinese burn medicine and promoted the development of world burn medicine.

  9. Professor Barrie Vernon-Roberts, AO, MD, BSc, PhD, FRCPath, FRCPA, FAOrthA (Hon), FRS.SA.

    Science.gov (United States)

    Rainsford, K D; Haynes, D R

    2013-08-01

    This issue of Inflammopharmacology contains papers that have been submitted to commemorate the life and work of Professor Barrie Vernon-Roberts, an outstanding clinical scientist in the field of bone pathology and its pharmacological regulation. This review briefly summarizes his major works and achievements as well as a list of his publications.

  10. Américo Negrette and Huntington's disease

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    Mariana Moscovich

    2011-08-01

    Full Text Available The authors present a historical review of the seminal clinical contribution of Professor Américo Negrette, a Venezuelan neurologist, to the evolution of scientific knowledge about Huntington's disease.

  11. Huntington's disease

    DEFF Research Database (Denmark)

    Hjermind, Lena Elisabeth; Law, Ian; Jønch, Aia

    2011-01-01

    In this open-label pilot study, the authors evaluated the effect of memantine on the distribution of brain glucose metabolism in four Huntington's disease (HD) patients as determined by serial 18-fluoro-deoxyglucose [F(18)]FDG-PET scans over a period of 3-4 months (90-129 days, with one patient...

  12. Serviço de apoio a distância ao professor em sala de aula pela tv digital interativa

    Directory of Open Access Journals (Sweden)

    José Manuel Martin Rios

    2004-01-01

    Full Text Available Este é um artigo de um projeto em andamento desenvolvido em parceria com a Diretoria Técnica de Serviços do CPqD Telecom & IT Solutions e a Faculdade de Educação da UNICAMP, que objetiva estabelecer um serviço de apoio a distância aos professores em sala de aula em 03 Escolas da região de Barão Geraldo em Campinas/ SP , para utilizar a TV Digital Interativa como ferramenta de busca e desenvolvimento de conteúdo multimídia interativo nas práticas pedagógicas. Fundamentalmente esta ferramenta será de fácil uso por utilizar como terminal de escolha e exibição um televisor colocado nas salas de aula das escolas e controlado por controle remoto. O professor poderá interagir com o conteúdo exibido no televisor de modo a obter uma programação não linear que se desenvolverá conforme o seu projeto pedagógico. As principais características do serviço são a facilidade de uso, fornecimento a distância de material multimídia interativo, baixo custo de implantação e grande área geográfica de cobertura, proporcionada pela disponibilidade quase total de sinal de televisão no território nacional. Este serviço é parte de um conjunto de serviços de teleducação que estão sendo desenvolvidos para o futuro Sistema de TV Digital terrestre que será implantado no Brasil.

  13. Psychopathology in Huntington's disease

    NARCIS (Netherlands)

    Duijn, Erik van

    2010-01-01

    Dit proefschrift begint met een overzichtsartikel van oorspronkelijke onderzoek naar psychopathologie bij mutatiedragers voor de ziekte van Huntington. Aansluitend worden de resultaten van een cohortstudie naar de aanwezigheid en ernst van psychopathologie bij mensen met de ziekte van Huntington in

  14. Vulnerabilidade ao stress, estratégias de coping e autoeficácia em professores portugueses Vulnerability to stress, coping strategies and self-efficiency among Portuguese teachers

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    Margarida Pocinho

    2009-08-01

    Full Text Available Neste trabalho, apresentamos uma investigação realizada com professores, no qual se procura determinar a vulnerabilidade ao stress; identificar as principais fontes de stress; estabelecer as principais estratégias de coping; analisar se as estratégias deste condicionam a presença de stress laboral; e reconhecer se a autoeficácia percebida é preditora desse tipo de stress. Trata-se duma investigação por questionário, do tipo correlacional, e a amostra é constituída por 54 professores do Ensino Básico público português. As respostas ao Questionário sociodemográfico e profissional; ao Questionário de Vulnerabilidade ao Stress - 23QVS (Serra, 2000; ao Questionário de Stress nos Professores - QSP (Gomes et al., 2006; Gomes, 2007; ao Coping Job Scale - CJS de Latack (adaptação de Jesus & Pereira, 1994; e à Escala de Avaliação de Autoeficácia Geral (Ribeiro, 1995 revelam que 20,4% dos docentes são vulneráveis ao stress; os comportamentos inadequados/indisciplina dos alunos são as principais fontes de stress; as estratégias de controlo são as mais utilizadas pelos participantes para enfrentar o stress, seguidas das de escape e das de gestão de sintomas. Os professores não vulneráveis ao stress utilizam principalmente estratégias de controlo e apresentam níveis mais elevados de eficácia perante a adversidade, bem como de iniciativa e persistência em relação aos professores vulneráveis ao stress.In this work we present a research carried out on teachers to determine their vulnerability to stress, to identify the main sources of stress, to recognize teachers' main coping strategies, to analyze whether such strategies condition the presence of stress at work, and to establish whether the self-efficiency perceived can be used to predict work stress. This is a correlational questionnaire-based research performed on a 54-teacher sample from Portugal's public basic education schools. The answers to the Social, Demographic

  15. Inglês Sem Fronteiras: uma mirada ao contexto de prática pelo prisma da formação de professores a partir do trabalho docente

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    Simone Sarmento

    2015-06-01

    Full Text Available http://dx.doi.org/10.5007/2175-8026.2015v68n1p47 O Programa Inglês sem Fronteiras (agora Idiomas sem Fronteiras - IsF é uma política pública que foi primeiramente pensada para oferecer cursos de inglês de modo a capacitar os estudantes elegíveis ao Ciência sem Fronteiras a estudarem em universidades estrangeiras. Entretanto, na prática, há um número de outras implicações, ou efeitos, que são visíveis para todos os seus participantes, sendo a formação de professores de língua inglesa umas das principais, pois grande parte dos professores bolsistas do Programa são alunos de licenciatura em Letras. Neste artigo, enfocamos o Núcleo de Língua Inglesa (NucLi do IsF-UFRGS, do qual 12 professores foram submetidos a um questionário online feito através do Google Forms. Os dados, embora preliminares, mostram que o IsF apresenta-se como um palco para o desenvolvimento de professores com o potencial de integrar relexão teórica e prática a partir de experiências concretas vivenciadas no trabalho docente.

  16. Estratégias didático-pedagógicas como alternativas para o ensino de Biologia Celular: curso aos professores de escolas públicas de Ensino Médio de Curitibanos-SC

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    Viviane Glaser

    2017-12-01

    Full Text Available As atividades práticas em Biologia Celular no Ensino Médio são importantes para a aprendizagem; contudo, a maioria das escolas não apresenta laboratórios e equipamentos para tal. Nessas situações, os educadores precisam criar estratégias para o conteúdo ser atrativo, as quais podem ser geradas a partir do conhecimento adquirido em cursos de formação continuada. O objetivo deste trabalho foi descrever o curso de formação continuada ministrado para professores do Ensino Médio do município de Curitibanos-SC, com foco na elaboração de modelos didáticos. O curso foi voltado para a rede pública de ensino, onde diferentes estratégias foram abordadas para o ensino de Biologia Celular. A atividade permitiu aos professores a troca de ideias sobre as abordagens utilizadas em aula, propiciando um ambiente de discussão das práticas pedagógicas. Houve ativa participação dos professores, além de motivação para a pesquisa e criação de estratégias para tornar as aulas mais atrativas para os alunos.

  17. Exploring Genetic Factors Involved in Huntington Disease Age of Onset

    DEFF Research Database (Denmark)

    Valcárcel-Ocete, Leire; Alkorta-Aranburu, Gorka; Iriondo, Mikel

    2015-01-01

    age (motor AO or mAO). Multiple linear regression analyses were performed between genetic variation within 20 candidate genes and eAO or mAO, using DNA and clinical information of 253 HD patients from REGISTRY project. Gene expression analyses were carried out by RT-qPCR with an independent sample......Age of onset (AO) of Huntington disease (HD) is mainly determined by the length of the CAG repeat expansion (CAGexp) in exon 1 of the HTT gene. Additional genetic variation has been suggested to contribute to AO, although the mechanism by which it could affect AO is presently unknown. The aim...... of this study is to explore the contribution of candidate genetic factors to HD AO in order to gain insight into the pathogenic mechanisms underlying this disorder. For that purpose, two AO definitions were used: the earliest age with unequivocal signs of HD (earliest AO or eAO), and the first motor symptoms...

  18. Learning about Huntington's Disease

    Science.gov (United States)

    Skip to main content Learning About Huntington's Disease Enter Search Term(s): Español Research Funding An Overview Bioinformatics Current Grants Education and Training Funding Extramural Research ...

  19. VT Data - Zoning 20120709, Huntington

    Data.gov (United States)

    Vermont Center for Geographic Information — Zoning district data for the Town of Huntington, Vermont. For details regarding each zoning district refer to the current zoning regulations on town of Huntington's...

  20. El papel de la institución en el escoger, acoger y acompañar al profesor universitario O papel da instituição para escolher, acolher e acompanhar ao professor universitário The role of the institution in choosing, receiving and chaperone professors in the university

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes da Silva Marques Ferreira

    2011-03-01

    Full Text Available Objetivo. Analizar el papel de la institución en el proceso de escoger, acoger y acompañar al profesor universitario. Metodología. Estudio cualitativo cuyo cuerpo de análisis estuvo compuesto por 32 participaciones en un foro temático de un grupo de nueve profesionales del área de la salud. Resultados. Después de la contratación del profesor es necesario acogerlo y acompañarlo. Los profesores con mayor tiempo en la institución representan un papel importante en la acogida del nuevo compañero. El proceso de acompañamiento es una oportunidad para cambios y redefinición de reglas y debe ser apoyado por la evaluación permanente. La universidad como escenario legítimo de aprendizaje, producción y reconstrucción de conocimiento debe acompañar las transformaciones de la ciencia contemporánea y apoyar las exigencias interdisciplinarias en la construcción de nuevo conocimiento. Conclusión. Es fundamental el papel de la universidad en acoger y acompañar al docente desde su vinculación; así mismo la universidad debe favorecer el crecimiento del profesor, no solo apoyando los desafíos de su actividad pedagógica, sino principalmente a través del respeto de su autonomía.Objetivo. Analisar o papel da instituição ao escolher, acolher e acompanhar ao professor universitário. Metodologia. Estudo qualitativo, cujo corpo de análise esteve composto por 32 participações num foro temático de um grupo de nove profissionais da área da saúde. Resultados. Depois da contratação do professor, é necessário acolhê-lo e acompanhá-lo. Os professores com maior tempo de instituição representam um papel importante na acolhida do novo colega. O processo de acompanhamento é uma oportunidade para mudanças e redefinição de regras, e deve ser apoiado pela avaliação permanente. A universidade como palco legítimo de aprendizagem, produção e reconstrução de conhecimento deve acompanhar as transformações da ciência contemporânea e

  1. Huntington\\'s disease: Genetic heterogeneity in black African patients

    African Journals Online (AJOL)

    Objective. Huntington's disease (HD) has been reported to occur rarely in black patients. A new genetic variant– Huntington's disease-like 2 (HDL2) – occurring more frequently in blacks, has recently been described. The absence of an expanded trinucleotide repeat at the chromosome 4 HD locus was previously regarded ...

  2. Clinical neurogenetics: huntington disease.

    Science.gov (United States)

    Bordelon, Yvette M

    2013-11-01

    Huntington disease (HD) is an autosomal dominant, adult-onset, progressive neurodegenerative disease characterized by the triad of abnormal movements (typically chorea), cognitive impairment, and psychiatric problems. It is caused by an expanded CAG repeat in the gene encoding the protein huntingtin on chromosome 4 and causes progressive atrophy of the striatum as well as cortical and other extrastriatal structures. Genetic testing has been available since 1993 to confirm diagnosis in affected adults and for presymptomatic testing in at-risk individuals. This review covers HD signs, symptoms, and pathophysiology; current genetic testing issues; and current and future treatment strategies. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. agradecimento aos consultores ad hoc

    Directory of Open Access Journals (Sweden)

    REA Editor

    2012-02-01

    Full Text Available Agradecemos aos professores Nildo Viana (UFG e Flavio Sofiati (UFG, organizadores do DOSSIÊ JUVENTUDE & SOCIEDADE, e aos Consultores Ad hoc pela leitura e apreciação crítica dos artigos submetidos e publicados nesta edição.

  4. ESTRATÉGIAS PEDAGÓGICAS EMPREGADAS POR PROFESSORES DE EDUCAÇÃO ESPECIAL AOS SEUS ALUNOS COM DEFICIÊNCIA INTELECTUAL SEVERA: UM ESTUDO DESCRITIVO DA PRÁTICA DOCENTE

    Directory of Open Access Journals (Sweden)

    Patricia Moralis CARAMORI

    2015-12-01

    Full Text Available RESUMO Esta pesquisa aborda a temática da educação de indivíduos com deficiência intelectual severa a partir das estratégias pedagógicas utilizadas por professoras de Educação Especial. Justifica-se por abordar o processo educacional de uma população pouco investigada, além de unir dois eixos de discussão de forma inovadora: a Teoria da Modificabilidade Cognitiva Estrutural (MCE de Reuven Feuerstein e a educação de alunos severamente prejudicados. Segundo essa Teoria, o professor atua como mediador, interpondo-se entre os estímulos do ambiente e o aluno. Seu objetivo pauta-se na descrição e análise da implementação do processo educacional de alunos com deficiência intelectual severa, enfocando as estratégias pedagógicas de professoras de Educação Especial na cidade de Araraquara. Os procedimentos iniciais indicam o estabelecimento dos perfis das professoras, seu mapeamento e localização. Definidos os participantes, a coleta dos dados se deu por meio de três instrumentos: entrevista semiestruturada realizada com as professoras e observação, registrada em protocolo e em diário de campo. Os dados foram analisados qualitativamente a fim de permitir a extração de detalhes do cotidiano observado. Os resultados apresentam uma descrição do trabalho das quatro professoras participantes, evidenciando suas opiniões sobre suas práticas, além de arrolar as estratégias pedagógicas utilizadas. Oferece-se como conclusão a identificação de estratégias pedagógicas que se relacionam com os critérios que regem a mediação. Isso mostra que é possível associar as idéias de Feuerstein às práticas pedagógicas voltadas aos alunos com deficiência intelectual severa, já que determinados procedimentos empregados demonstram trazer em seu cerne alguns preceitos essenciais à mediação.

  5. Huntington's disease presenting as amyotrophic lateral sclerosis.

    LENUS (Irish Health Repository)

    Phukan, Julie

    2010-08-01

    We present the clinical, electrophysiological and molecular genetic findings of a 58-year-old male with genetically confirmed Huntington\\'s disease (HD) and concurrent clinically definite ALS by El Escorial criteria. The patient presented with asymmetric upper limb amyotrophy and weakness, and subsequently developed chorea and cognitive change. Genetic testing confirmed the presence of expanded trinucleotide repeats in huntingtin, consistent with a diagnosis of Huntington\\'s disease. This case confirms the rare coexistence of Huntington\\'s disease and motor neuron degeneration.

  6. A relação entre as crenças verbalizadas e depreendidas das ações do professor de Língua Inglesa no que tange ao ensino mediado pelas novas tecnologias

    Directory of Open Access Journals (Sweden)

    Kássia Gonçalves Arantes

    2012-12-01

    Full Text Available O objetivo deste trabalho é investigar a relação entre o dizer e o fazer do professor, no que tange à influência das novas tecnologias no ensino e aprendizagem de língua inglesa, bem como identificar os fatores que se articulam para o estabelecimento dessa relação. Para tanto, fazemos o confronto entre as crenças manifestadas no dizer do professor e as crenças depreendidas de seu fazer. Inserida numa perspectiva predominantemente qualitativa de cunho interpretativista, a pesquisa adota uma abordagem contextual de investigação de crenças de professores. O trabalho é fundamentado teoricamente em estudos que abordam as crenças de professores, o papel das novas tecnologias nos processos de ensino e aprendizagem de língua estrangeria, e a relação entre o professor reflexivo e a utilização das novas tecnologias. Os principais resultados encontrados apontam predominantemente para uma relação de dissonância entre o dizer e o fazer dos professores, e os fatores articuladores dessa relação se enquadram em quatro classes, a saber: fatores contextuais, experienciais, cognitivos e afetivos.

  7. Music therapy in Huntington's disease

    NARCIS (Netherlands)

    Bruggen-Rufi, van C.H.M.

    2018-01-01

    The thesis reports about the effects of music therapy with patients in the late stage of Huntington's disease. A literature review, a focus group study, a randomized controlled trial, an evaluation for complex interventions and a case report study are integrated in the thesis. The beneficial

  8. A PERCEPÇÃO DOS PROFESSORES EM RELAÇÃO AO SISTEMA DE AVALIAÇÃO NORMATIZADO PELA ACADEMIA DA POLÍCIA MILITAR, COM FOCO NA AVALIAÇÃO DA APRENDIZAGEM / Teacher's perveption in relation to the evaluation system standardized by the Academy of Military Police,c

    Directory of Open Access Journals (Sweden)

    Maria das Graças Mota Mourão

    2014-09-01

    Full Text Available O estudo analisou a percepção dos professores em relação ao sistema de avaliação normatizado pela Academia da Polícia Militar (PM, centrado na avaliação da aprendizagem, visando compreender características inovadoras e entraves do processo. Trata-se de estudo de caso constituído por 8 docentes da 103ª Companhia de Ensino e Treinamento do 10º Batalhão da PM de Minas Gerais, em Montes Claros. Na coleta de dados, aplicou-se entrevista semi-estruturada. Os docentes reconhecem a avaliação da aprendizagem como essencial no processo educativo e a desenvolvem de forma tradicional, enquanto poucos discordam da supervalorização dos exames em detrimento dos aspectos formativos. A maioria diz que a flexibilidade das normas possibilitaria a autonomia na tomada das decisões para melhorar a aprendizagem. Palavras-chave: Avaliação da aprendizagem. Ensino. Polícia Militar. Professores.

  9. Autonomia profissional dos professores

    OpenAIRE

    Guerra, Teresa P.; Veiga, Feliciano

    2007-01-01

    Este estudo pretendeu analisar as representações dos professores acerca da sua autonomia em contexto escolar, com recurso a uma amostra de 203 professores de ambos os sexos, pertencentes a escolas dos distritos de Lisboa, Setúbal, Leiria e Aveiro. Utilizou-se a Escala de Autonomia Profissional dos Professores (EAPP).

  10. Huntington's disease: a perplexing neurological disease ...

    African Journals Online (AJOL)

    Huntington's disease is an inherited intricate brain illness. It is a neurodegenerative, insidious disorder; the onset of the disease is very late to diagnose. It is caused by an expanded CAG repeat in the Huntingtin gene, which encodes an abnormally long polyglutamine repeat in the Huntingtin protein. Huntington's disease ...

  11. Huntington's disease : Psychological aspects of predictive testing

    NARCIS (Netherlands)

    Timman, Reinier

    2005-01-01

    Predictive testing for Huntington's disease appears to have long lasting psychological effects. The predictive test for Huntington's disease (HD), a hereditary disease of the nervous system, was introduced in the Netherlands in the late eighties. As adverse consequences of the test were

  12. Development and evaluation of psychometric properties of an inventory of teachers' perceptions on socio-emotional needs Desenvolvimento e avaliação das características psicométricas do inventário de avaliação das percepções dos professores acerca das necessidades ao nível da promoção de competências sociais e emocionais

    Directory of Open Access Journals (Sweden)

    Paulo A. S. Moreira

    2013-01-01

    Full Text Available The objective of this study was to evaluate the psychometric properties of an assessment instrument on teachers' perceptions regarding the development of socio-emotional skills. Results revealed a consistent four-factor structure (School/teachers' needs for socio-emotional skills promotion; Needs regarding teaching-learning process; Difficulties in dealing with students' socio-emotional deficits, Socio-emotional needs related to teacher's initial training with internal consistency values above .79. Confirmatory analyses revealed a good fit of the model to the data. Teachers reported having more needs at the school/ teachers conditions for the promotion of social and emotional needs, and less needs at the level of their Teachers' initial training. The instrument also showed to be sensitive in capturing teachers' perception of schooling social and emotional needs in terms of teachers' gender, pedagogic group and school level.O objectivo deste estudo foi avaliar as características psicométricas de um instrumento de avaliação das percepções dos professores acerca das suas necessidades na promoção das competências sociais e emocionais. Os resultados revelaram uma estrutura de quatro factores (Necessidades ao nível da escola/professor, necessidades ao nível do processo de ensino-aprendizagem, Dificuldades em lidar com défices sócio-emocionais dos alunos e Necessidades ao nível da formação inicial, com valores de consistência interna acima de 0,79. As análises confirmatórias revelaram bom ajustamento do modelo aos dados. Os professores revelaram sentir maiores dificuldades ao nível das condições da escola/ professores e menores ao nível da formação inicial. O instrumento revelou-se também sensível às diferenças de percepções em termos do género, grupo pedagógico, e nível de ensino.

  13. DAR VOZ AOS PROFESSORES DE EDUCAÇÃO FÍSICA: AS HISTÓRIAS DE VIDA SOBRE OS MOMENTOS SIGNIFICATIVOS EM RELAÇÃO AS FASES DA CARREIRA DOCENTE

    Directory of Open Access Journals (Sweden)

    Hugo Norberto Krug

    2013-12-01

    Full Text Available Este estudo objetivou analisar a carreira de professores de Educação Física Escolar de uma cidade do sul do Brasil, numa perspectiva de desenvolvimento profissional e de percurso de formação, identificando os momentos significativos desse mesmo percurso, e, ainda, caracterizando os momentos identificados considerando as fases do percurso profissional docente. A metodologia caracterizou-se como qualitativa com abordagem (autobiográfica onde utilizamos a narrativa oral que foi gravada, transcrita e analisada à luz da identificação dos significados. Participaram dez professoras. Concluímos que os melhores e piores momentos, os problemas sentidos, os momentos de ruptura profissional e a motivação para a carreira podem ocorrer em quaisquer momentos da docência, independentemente da fase do percurso profissional e por diversas razões. Estes traços caracterizadores ajudam a delinear um perfil de carreira que, mesmo não sendo de forma linear entre as professoras, deixam marcas positivas e/ou negativas.

  14. Psychiatric symptoms and CAG expansion in Huntington`s disease

    Energy Technology Data Exchange (ETDEWEB)

    Weber, M.W.; Schmid, W.; Spiegel, R. [Univ. of Zuerich (Switzerland)

    1996-02-16

    The mutation responsible for Huntington`s disease (HD) is an elongated CAG repeat in the coding region of the IT15 gene. A PCR-based test with high sensitivity and accuracy is now available to identify asymptomatic gene carriers and patients. An inverse correlation between CAG copy number and age at disease onset has been found in a large number of affected individuals. The influence of the CAG repeat expansion on other phenotypic manifestations, especially specific psychiatric symptoms has not been studied intensively. In order to elucidate this situation we investigated the relation between CAG copy number and distinct psychiatric phenotypes found in 79 HD-patients. None of the four differentiated categories (personality change, psychosis, depression, and nonspecific alterations) showed significant differences in respect to size of the CAG expansion. In addition, no influence of individual sex on psychiatric presentation could be found. On the other hand in patients with personality changes maternal transmission was significantly more frequent compared with all other groups. Therefore we suggest that clinical severity of psychiatric features in HD is not directly dependent on the size of the dynamic mutation involved. The complex pathogenetic mechanisms leading to psychiatric alterations are still unknown and thus genotyping does not provide information about expected psychiatric symptoms in HD gene carriers. 40 refs., 1 fig., 2 tabs.

  15. Conhecimento gramatical e conceções de futuros professores relativamente ao ensino e à aprendizagem da gramática / Pre-service teacher’s knowledge and beliefs regarding teaching and learning grammar

    Directory of Open Access Journals (Sweden)

    Patrícia Santos Ferreira

    2014-10-01

    Full Text Available Resumo: Com este texto, pretende-se apresentar alguns dos resultados da primeira etapa da recolha de dados realizada no âmbito de um trabalho de investigação centrado na problemática do papel da formação inicial sobre a construção do conhecimento profissional e as práticas em ensino e aprendizagem da gramática. Foram, nesta etapa, inquiridos 54 estudantes do 1.º ano do programa de formação inicial de professores de 1.º e 2.º ciclos de uma instituição de ensino superior politécnico de Lisboa. Estes participantes responderam a três questionários, concebidos para recolher informação relacionada com os objetivos gerais de investigação 1 e 2, ou seja, conhecer conceções sobre o ensino e a aprendizagem da gramática dos estudantes dos cursos de formação de professores do 1.º (alunos con 6 a 10 anos e do 2.º (alunos con 10 a 12 anos ciclos do ensino básico e caracterizar o conhecimento gramatical desses alunos. A recolha foi feita na primeira semana de aulas do ano letivo 2013- 2014, no início do programa de formação inicial. A análise dos dados permitiu identificar a motivação para a aprendizagem e para o ensino da gramática e o predomínio de uma visão instrumental, prescritiva e reguladora desta competência. Por outro lado, os participantes evidenciaram sérias dificuldades no âmbito do conhecimento científico e na sua explicitação. Abstract: This text presents some of the results of the first phase of the data collection conducted within a research work focused on the role of pre-service teacher education in the development of professional knowledge and practices in grammar teaching and learning. At this stage, 54 individuals of the first year of the pre-service 1st (6 to 10 years-old students and 2nd (10 to 12 years-old students cycles teacher education program of a polytechnic higher education school were inquired. They responded to three questionnaires, conceived in order to collect data related to the

  16. Personality Traits in Huntington's Disease

    DEFF Research Database (Denmark)

    Larsen, Ida Unmack; Mortensen, Erik Lykke; Vinther-Jensen, Tua

    2016-01-01

    Huntington's disease (HD) is associated with risk for developing psychiatric symptoms. Vulnerability or resilience to psychiatric symptoms may be associated with personality traits. This exploratory study, aimed to investigate personality traits in a large cohort of HD carriers and at risk gene......-expansion negative individuals (HD non-carriers), exploring whether carrying the HD gene or growing up in an HD family influences personality traits. Forty-seven HD carriers, Thirty-nine HD non-carriers, and 121 healthy controls answered the Danish version of the revised NEO personality inventory. Comparisons...... symptoms. Our findings suggest that, there is no direct effect of the HD gene on personality traits, but that personality assessment may be relevant to use when identifying individuals from HD families who are vulnerable to develop psychiatric symptoms....

  17. Clinical presentation of juvenile Huntington disease

    Directory of Open Access Journals (Sweden)

    Ruocco Heloísa H.

    2006-01-01

    Full Text Available OBJECTIVE: To describe the clinical presentation a group of patients with juvenile onset of Huntington disease. METHOD: All patients were interviewed following a structured clinical questioner. Patients were genotyped for the trinucleotide cytosine-adenine-guanine (CAG repeat in the Huntington Disease gene. High resolution brain MRI was performed in all patients. RESULTS: We identified 4 patients with juvenile onset of disease among 50 patients with Huntington disease followed prospectively in our Neurogenetics clinic. Age at onset varied from 3 to 13 years, there were 2 boys, and 3 patients had a paternal inheritance of the disease. Expanded Huntington disease allele sizes varied from 41 to 69 trinucleotide repeats. The early onset patients presented with rigidity, bradykinesia, dystonia, dysarthria, seizures and ataxia. MRI showed severe volume loss of caudate and putamen nuclei (p=0.001 and reduced cerebral and cerebellum volumes (p=0.01. CONCLUSION: 8% of Huntington disease patients seen in our clinic had juvenile onset of the disease. They did not present with typical chorea as seen in adult onset Huntington disease. There was a predominance of rigidity and bradykinesia. Two other important clinical features were seizures and ataxia, which related with the imaging findings of early cortical atrophy and cerebellum volume loss.

  18. Huntington's disease: a clinical review

    Directory of Open Access Journals (Sweden)

    Roos Raymund AC

    2010-12-01

    Full Text Available Abstract Huntington disease (HD is a rare neurodegenerative disorder of the central nervous system characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia. Prevalence in the Caucasian population is estimated at 1/10,000-1/20,000. Mean age at onset of symptoms is 30-50 years. In some cases symptoms start before the age of 20 years with behavior disturbances and learning difficulties at school (Juvenile Huntington's disease; JHD. The classic sign is chorea that gradually spreads to all muscles. All psychomotor processes become severely retarded. Patients experience psychiatric symptoms and cognitive decline. HD is an autosomal dominant inherited disease caused by an elongated CAG repeat (36 repeats or more on the short arm of chromosome 4p16.3 in the Huntingtine gene. The longer the CAG repeat, the earlier the onset of disease. In cases of JHD the repeat often exceeds 55. Diagnosis is based on clinical symptoms and signs in an individual with a parent with proven HD, and is confirmed by DNA determination. Pre-manifest diagnosis should only be performed by multidisciplinary teams in healthy at-risk adult individuals who want to know whether they carry the mutation or not. Differential diagnoses include other causes of chorea including general internal disorders or iatrogenic disorders. Phenocopies (clinically diagnosed cases of HD without the genetic mutation are observed. Prenatal diagnosis is possible by chorionic villus sampling or amniocentesis. Preimplantation diagnosis with in vitro fertilization is offered in several countries. There is no cure. Management should be multidisciplinary and is based on treating symptoms with a view to improving quality of life. Chorea is treated with dopamine receptor blocking or depleting agents. Medication and non-medical care for depression and aggressive behavior may be required. The progression of the disease leads to a complete dependency in daily life, which

  19. Discrepancies in reporting the CAG repeat lengths for Huntington's disease

    DEFF Research Database (Denmark)

    Quarrell, Oliver W; Handley, Olivia; O'Donovan, Kirsty

    2011-01-01

    Huntington's disease results from a CAG repeat expansion within the Huntingtin gene; this is measured routinely in diagnostic laboratories. The European Huntington's Disease Network REGISTRY project centrally measures CAG repeat lengths on fresh samples; these were compared with the original...

  20. Happy Birthday Professor Telegdi

    CERN Multimedia

    2002-01-01

    Professor Telegdi, pictured with Luciano Maiani and Alexander Skrinsky, receiving the medal of foreign member of the Russian Academy of Sciences in June 2000. Professor Valentine Telegdi celebrated his 80th birthday on Friday, 11th January. A brilliant American physicist of Hungarian origin, Professor Telegdi was a professor at the University of Chicago, the Swiss Federal Institute of Technology in Zurich (ETHZ) and the California Institute of Technology and took part in many CERN experiments, of which NA10 and L3 were the most recent. He served as Chairman of CERN's Scientific Policy Committee from 1981 to 1983. A member of numerous scientific academies, he shared the prestigious Wolf Prize with Maurice Goldhaber in 1991 in recognition of their separate seminal contributions to nuclear and particle physics, particularly those concerning weak interactions involving leptons.

  1. Perceptions of genetic discrimination among people at risk for Huntington?s disease: a cross sectional survey

    OpenAIRE

    Bombard, Yvonne; Veenstra, Gerry; Friedman, Jan M; Creighton, Susan; Currie, Lauren; Paulsen, Jane S; Bottorff, Joan L; Hayden, Michael R

    2009-01-01

    Objective To assess the nature and prevalence of genetic discrimination experienced by people at risk for Huntington?s disease who had undergone genetic testing or remained untested. Design Cross sectional, self reported survey. Setting Seven genetics and movement disorders clinics servicing rural and urban communities in Canada. Participants 233 genetically tested and untested asymptomatic people at risk for Huntington?s disease (response rate 80%): 167 underwent testing (83 had the Huntingt...

  2. Aspectos gerais da formação de professores

    Directory of Open Access Journals (Sweden)

    Edson do Carmo Inforsato

    1996-08-01

    Full Text Available Este artigo, ancorado em estudos recentes e antigos, mostra o afastamento dos cursos de formação de professores em relação aos elementos que compõem a prática profissional docente. Favorável a uma aproximação efetiva com o contexto das práticas de sala de aula, o autor defende a idéia de uma formação de professores atrelada aos problemas e necessidades da prática docente no ensino formal de 1º e 2º graus.

  3. PROFESSORES: IMAGENS DO FUTURO PRESENTE

    Directory of Open Access Journals (Sweden)

    Maitê Alves Bezerra

    2014-06-01

    Full Text Available Ao observar a comunidade portuguesa que busca compreender a historicidade das formas e dos processos de escolarização por meio do estabelecimento de intenso diálogo com outras comunidades, é impossível não dar destaque à figura de António Manuel Seixas Nóvoa. Nascido em Lisboa no ano de 1954, aos 18 anos inicia o curso de Ciências da Educação na Universidade de Lisboa. Após lecionar em importantes universidades tais como Paris V, Oxford e Columbia University, atualmente acumula as posições de reitor da Universidade de Lisboa e professor catedrático da Faculdade de Psicologia e de Ciências da Educação na Instituição. Nóvoa tem se destacado à frente de debates internacionais a respeito da história da educação e educação comparada.

  4. Difficulties of First Years Elementary School Teachers with the Teaching of Astronomy. (Breton Title: Dificuldades de Professores dos Anos Iniciais do Ensino Fundamental em Relação ao Ensino da Astronomia. ) Dificultades de LOS Profesores de los Primeros Años de la Escuela Primaria en Relación a la Enseñanza de la Astronomía

    Science.gov (United States)

    Langhi, Rodolfo; Nardi, Roberto

    2005-12-01

    This paper reports Primary School teachers' discourses analysis about their difficulties related to the teaching of Astronomy. It reports partial data of a master's level research carried out in the last two years, named "An exploratory study for inserting Astronomy in primary school teachers' education" (LANGHI, 2004). The study took into consideration students' and teachers' common sense conceptions about astronomical phenomena, conceptual mistakes in textbooks, and Astronomy's suggestions given by the PCN (Parâmetros Curriculares Nacionais - The Brazilian National Curriculum Standards). The paper aims to characterize teachers' difficulties, in order to provide subsides to the implementation of an initial or continuing education program. This study is justified by the fact that courses plans like these only will be adapted to the teacher's (and students') reality, if there is a primary investigation about what the teachers really need to know about Astronomy. This fact was possible here by the enunciations interpretation of a teachers' sample using semi-structured interviews, according to discourse analysis procedures. The research outcomes show difficulties related to factors like: those of personal order, methodological, on teacher's formation, educational infrastructure and other related to information sources for educators. Este artigo, que relata as dificuldades de professores em relação ao ensino da Astronomia, faz parte de um estudo exploratório para a inserção da Astronomia na formação de professores dos anos iniciais do Ensino Fundamental. Esse estudo leva em consideração as concepções alternativas de alunos e professores sobre fenômenos astronômicos, os erros conceituais em livros didáticos e as sugestões de conteúdos de Astronomia constantes nos PCN (Parâmetros Curriculares Nacionais). Caracterizar as dificuldades dos professores é a questão central deste texto, apontando para o objetivo de contribuir com subsídios para um futuro

  5. Mapping energy poverty in Huntington, West Virginia

    Science.gov (United States)

    Callicoat, Elizabeth Anne

    Energy poverty is a growing phenomenon culminating from the combination of low to mid household income, deteriorating housing structures and rising household energy costs. Energy prices are increasing for all households, but the burden is proportionally larger for those with low to mid income. These groups must sacrifice to afford energy, and are often unable or do not have the autonomy to make structural improvements, especially if they rent their home. Data on residential dwellings from the Cabell County Tax Assessor's Office was used within a geographic information system to map where energy poverty likely exists within the city limits of Huntington, WV. It was found that one fifth of Huntington households are at a high risk of energy poverty, primarily located across the northern section of the city and in the center, surrounding Marshall University, Downtown and Cabell Huntington Hospital.

  6. Professor Michael Levitt

    Directory of Open Access Journals (Sweden)

    Gemma-Louise Davies

    2015-10-01

    Full Text Available Professor Michael Levitt (Stanford University, USA won the 2013 Nobel Prize in Chemistry for the development of multiscale models for complex chemical systems—computational tools which can calculate the course of chemical reactions. Professor Levitt was born in Pretoria, South Africa; he came to the UK on a summer vacation aged 16, where he decided to stay and study for his A‑levels. His interest in the physics of living systems drove him to study biophysics at King’s College London, before securing a PhD position at the Laboratory of Molecular Biology in Cambridge. In the interim year between his degree and beginning his PhD, Professor Levitt worked at the Weizmann Institute of Science in Israel, where he met his future wife. They married later that year and moved to Cambridge, where their three children were born. After completing his PhD, he spent time working in Israel, Cambridge, the Salk Institute and Stanford (both California. Since 1986, he has split his time between Israel and California. Outside of science, he is a keen hiker and he is well-known to have attended the eclectic ‘Burning Man’ Festival in California.[1] Professor Levitt visited the University of Warwick to speak at the Computational Molecular Science Annual Conference in March 2015. In this interview, Dr Gemma-Louise Davies, an Institute of Advanced Study Global Research Fellow, spoke to Professor Levitt about the importance of Interdisciplinarity in his field, role models in Academia, and his plans for the future. Image: Professor Michael Levitt (left with Dr Scott Habershon (right, organiser of the 2015 Computational Molecular Science Annual Conference during his visit to the University of Warwick in March 2015. [1] ‘Burning Man’ is a unique annual festival dedicated to community, art, music, self-expression and self-reliance. Tens of thousands of people flock to this temporary metropolis built in the Californian desert.

  7. Professor Torben Larsen

    DEFF Research Database (Denmark)

    Larsen, Torben

    2013-01-01

    En samling af væsentlige artikler, og diskussion, om stormflod skrevet af professor Torben Larsen, Aalborg Universitet. Torben Larsen diskuterer i artiklerne et forslag om at lukke Thyborøn Kanal for at mindske risikoen for stormflod og oversvømmelse langs Limfjordens byer.......En samling af væsentlige artikler, og diskussion, om stormflod skrevet af professor Torben Larsen, Aalborg Universitet. Torben Larsen diskuterer i artiklerne et forslag om at lukke Thyborøn Kanal for at mindske risikoen for stormflod og oversvømmelse langs Limfjordens byer....

  8. Kas Huntington oli prohvet? / Priit Simson

    Index Scriptorium Estoniae

    Simson Priit, 1977-

    2008-01-01

    Autor käsitleb Samuel Huntingtoni teese ning leiab, et tegelikult Huntington ei pakkunud õigustust islamiriikide ründamisele, vaid pigem hoiatas tsivilisatsioonide siseasjusse sekkumise, tekkida võiva ahelreaktsiooni eest, kus üks tsivilisatsiooni liige tõmbab sõtta ka teise

  9. Destination and source memory in Huntington's disease

    NARCIS (Netherlands)

    El Haj, M.; Caillaud, M.; Verny, C.; Fasotti, L.; Allain, P.

    2016-01-01

    Destination memory refers to the recall of the destination of previously relayed information, and source memory refers to the recollection of the origin of received information. We compared both memory systems in Huntington's disease (HD) participants. For this, HD participants and healthy adults

  10. A Metabolic Study of Huntington's Disease.

    Directory of Open Access Journals (Sweden)

    Rajasree Nambron

    Full Text Available Huntington's disease patients have a number of peripheral manifestations suggestive of metabolic and endocrine abnormalities. We, therefore, investigated a number of metabolic factors in a 24-hour study of Huntington's disease gene carriers (premanifest and moderate stage II/III and controls.Control (n = 15, premanifest (n = 14 and stage II/III (n = 13 participants were studied with blood sampling over a 24-hour period. A battery of clinical tests including neurological rating and function scales were performed. Visceral and subcutaneous adipose distribution was measured using magnetic resonance imaging. We quantified fasting baseline concentrations of glucose, insulin, cholesterol, triglycerides, lipoprotein (a, fatty acids, amino acids, lactate and osteokines. Leptin and ghrelin were quantified in fasting samples and after a standardised meal. We assessed glucose, insulin, growth hormone and cortisol concentrations during a prolonged oral glucose tolerance test.We found no highly significant differences in carbohydrate, protein or lipid metabolism markers between healthy controls, premanifest and stage II/III Huntington's disease subjects. For some markers (osteoprotegerin, tyrosine, lysine, phenylalanine and arginine there is a suggestion (p values between 0.02 and 0.05 that levels are higher in patients with premanifest HD, but not moderate HD. However, given the large number of statistical tests performed interpretation of these findings must be cautious.Contrary to previous studies that showed altered levels of metabolic markers in patients with Huntington's disease, our study did not demonstrate convincing evidence of abnormalities in any of the markers examined. Our analyses were restricted to Huntington's disease patients not taking neuroleptics, anti-depressants or other medication affecting metabolic pathways. Even with the modest sample sizes studied, the lack of highly significant results, despite many being tested, suggests that

  11. Professor Tiina Tasmuth Helsingis

    Index Scriptorium Estoniae

    2000-01-01

    Tervisekasvatuse õppetooli professor Tiina Tasmuth osales 11.-14. juunini Helsingis toimunud rahvusvahelise konverentsi "2nd Psycho-Social Impacts of Breast Cancer" töös ning esines ettekandega teemal "Chronic post-treatment symptoms in patients with breast cancer" : [täistekst

  12. Professor Kalkman retires

    NARCIS (Netherlands)

    Baas, Pieter

    1991-01-01

    On 13 December 1990 Prof. Dr. Cornelis (Kees) Kalkman retired from the positions of Professor of Plant Systematics and Scientific Director of the Rijksherbarium/ Hortus Botanicus by presenting his valedictory lecture to the academic community of Leiden University and the assembled Dutch Botanical

  13. Professor Wolfgang Panofsky

    CERN Multimedia

    2007-01-01

    "Professor Wolfgang panofsky, who died on September 24 aged 88, was a particle physicists and director of the Stanford Linear Accelerator Centre (SLAC) in California; with Jack Steinberger, he was the first to isolate the neutral pi meson, one of the subatomic particles which had been predicted by theoretical scientists to account for the strng force which binds the nuclei of atoms." (1 page)

  14. Professor og DMI

    DEFF Research Database (Denmark)

    Kaas, Eigil

    2010-01-01

    Det er koldt, og det har det været længe. Sammen med sneen har det en selvforstærkende effekt på vintervejret, forklarer professor og meteorolog. Kulde: - Det er koldt, fordi vinden kommer fra et sted, hvor det er koldt. Det er den enkle forklaring på, at Danmark og store dele af Europa lige nu...... oplever meget lave temperaturer - og for Danmarks vedkommende en usædvanlig lang periode med vintervejr. Forklaringen kommer fra professor Eigil Kaas fra Niels Bohr Instituttet ved Københavns Universitet. Han forklarer til jp.dk, at vintervejret dog er betinget af den mere eller mindre tilfældige måde...

  15. Professor Alex Callinicos

    OpenAIRE

    Ali Saqer

    2016-01-01

    Professor Alex Callinicos is a renowned social theorist and scholar of international political economy. He conducts research on Marx and Marxism, European social and political theory, contemporary political philosophy, critical theory, historiography, and international political economy. His work provides invaluable insights on issues of race and racism, social justice, the Third Way, imperialism, austerity, and EU politics, among many other fascinating contemporary issues. Alex studied Philo...

  16. The Wilson films--Huntington's chorea.

    Science.gov (United States)

    Klein, Christine

    2011-12-01

    Wilson's Queen Square Case 9 with Huntington's chorea shows a 68-year-old man with mild to moderate generalized chorea, impaired fixation, and probable cognitive decline in keeping with a diagnosis of Huntington's disease (HD). An age of onset in the late sixties and a negative family history suggest a relatively small expanded trinucleotide repeat in the HTT gene in the patient and reduced penetrance of an even shorter repeat allele in one of his parents. A highly sensitive and specific gene test has been offered worldwide for diagnostic testing of HD for almost two decades. This test, obviously unavailable at Wilson's times, became the historic frontrunner for guidelines of symptomatic, presymptomatic, and prenatal testing for an adult-onset neurodegenerative disorder. Regarding treatment of HD, however, we are still awaiting the successful translation of research results into the development of effective cause-directed, neuropreventive and neurorestaurative therapies. Copyright © 2011 Movement Disorder Society.

  17. [Sporadic juvenile forms of Huntington's chorea].

    Science.gov (United States)

    Zinchenko, A P; Goncharov, V D; Burtianskii, D L; Zakhar'ev, Iu M

    1980-01-01

    Six patients with Huntington's chorea in the age of 15-24 years old, suffered from diffusive choreic hyperkynesis with slowly progressive dementia. The development of this disease in childhood and adolescence was atypical, as nobody in the family and in kin sufferred from it and it was difficult to diagnose the disease. Recognition of the disease was promoted by pneumoencephalography, electromyography and memory investigation.

  18. Earliest functional declines in Huntington disease

    Science.gov (United States)

    Beglinger, Leigh J.; O'Rourke, Justin J.F.; Wang, Chiachi; Langbehn, Douglas R.; Duff, Kevin; Paulsen, Jane S.

    2013-01-01

    We examined the gold standard for Huntington disease (HD) functional assessment, the Unified Huntington's Disease Rating Scale (UHDRS), in a group of at-risk participants not yet diagnosed but who later phenoconverted to manifest HD. We also sought to determine which skill domains first weaken and the clinical correlates of declines. Using the UHDRS Total Functional Capacity (TFC) and Functional Assessment Scale (FAS), we examined participants from Huntington Study Group clinics who were not diagnosed at their baseline visit but were diagnosed at a later visit (N = 265). Occupational decline was the most common with 65.1% (TFC) and 55.6% (FAS) reporting some loss of ability to engage in their typical work. Inability to manage finances independently (TFC 49.2%, FAS 35.1%) and drive safely (FAS 33.5%) were also found. Functional decline was significantly predicted by motor, cognitive, and depressive symptoms. The UHDRS captured early functional losses in individuals with HD prior to formal diagnosis, however, fruitful areas for expanded assessment of early functional changes are performance at work, ability to manage finances, and driving. These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis. PMID:20471695

  19. Modulation at Age of Onset in Tunisian Huntington Disease Patients: Implication of New Modifier Genes

    Directory of Open Access Journals (Sweden)

    Dorra Hmida-Ben Brahim

    2014-01-01

    Full Text Available Huntington’s disease (HD is an autosomal dominant neurodegenerative disorder. The causative mutation is an expansion of more than 36 CAG repeats in the first exon of IT15 gene. Many studies have shown that the IT15 interacts with several modifier genes to regulate the age at onset (AO of HD. Our study aims to investigate the implication of CAG expansion and 9 modifiers in the age at onset variance of 15 HD Tunisian patients and to establish the correlation between these modifiers genes and the AO of this disease. Despite the small number of studied patients, this report consists of the first North African study in Huntington disease patients. Our results approve a specific effect of modifiers genes in each population.

  20. Professor Stewart's incredible numbers

    CERN Document Server

    Stewart, Ian

    2015-01-01

    Ian Stewart explores the astonishing properties of numbers from 1 to10 to zero and infinity, including one figure that, if you wrote it out, would span the universe. He looks at every kind of number you can think of - real, imaginary, rational, irrational, positive and negative - along with several you might have thought you couldn't think of. He explains the insights of the ancient mathematicians, shows how numbers have evolved through the ages, and reveals the way numerical theory enables everyday life. Under Professor Stewart's guidance you will discover the mathematics of codes,

  1. Clinical and genetic data of Huntington disease in Moroccan patients

    African Journals Online (AJOL)

    Background: Huntington's disease (HD) occurs worldwide with prevalence varying from 0.1 to 10 /100,000 depending of the ethnic origin. Since no data is available in the Maghreb population, the aim of this study is to describe clinical and genetic characteristics of Huntington patients of Moroccan origin. Methods: Clinical ...

  2. Juvenile Huntington's disease confirmed by genetic examination in twins Doença de Huntington juvenil confirmada por exame genético em gêmeas

    Directory of Open Access Journals (Sweden)

    GILBERTO LEVY

    1999-09-01

    Full Text Available Early-onset Huntington's disease (HD occurs in approximately 10% of HD's cases. We report juvenile HD in phenotypically identical twins, evaluated by history, clinical and neurologic examination, mini-mental state examination, blood laboratory exams, cerebrospinal fluid examination, skull computed tomography, and genetic examination for HD. Patients had the akinetic-rigid variety (Westphal variant of the disease and paternal inheritance. The laboratory workup confirmed the clinical diagnosis of HD, which adds this report to the rare cases of HD in twins reported in the literature.Doença de Huntington (DH de início precoce ocorre em aproximadamente 10% dos casos de DH. Relatamos DH juvenil em gêmeas fenotipicamente idênticas, avaliadas por história, exames clínico e neurológico, mini-exame do estado mental, exames de sangue, exame do líquido cefalorraquidiano, tomografia computadorizada de crânio e exame genético para DH. As pacientes apresentavam a variedade rígido-acinética (variante de Westphal da doença e herança paterna. A avaliação laboratorial confirmou o diagnóstico clínico de DH, acrescentando-se este relato aos raros casos de DH em gêmeos relatados na literatura.

  3. Identification of genetic variants associated with Huntington's disease progression

    DEFF Research Database (Denmark)

    Hensman Moss, Davina J; Pardiñas, Antonio F; Langbehn, Douglas

    2017-01-01

    indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008-11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers...... in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression......BACKGROUND: Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate...

  4. Professor Alex Callinicos

    Directory of Open Access Journals (Sweden)

    Ali Saqer

    2016-04-01

    Full Text Available Professor Alex Callinicos is a renowned social theorist and scholar of international political economy. He conducts research on Marx and Marxism, European social and political theory, contemporary political philosophy, critical theory, historiography, and international political economy. His work provides invaluable insights on issues of race and racism, social justice, the Third Way, imperialism, austerity, and EU politics, among many other fascinating contemporary issues. Alex studied Philosophy, Politics, and Economics at Balliol College, Oxford, and Philosophy of Science at the London School of Economics before writing a DPhil on Marx's Capital, also at Balliol. He was a Junior Research Fellow in Contemporary Social Thought at St Peter's College, Oxford from 1979 to 1981, after which he taught social and political theory at the Department of Politics at the University of York until 2005, when he moved to King's College London. Alex is currently the Professor of European Studies at King's and editor of International Socialism. Alex has been an active contributor to the development of the movement for another globalization, participating in the World Social Forum and an animator of the European Social Forum. Among his best known books are The Revolutionary Ideas of Karl Marx (1983, Against Postmodernism (1990, Social Theory (1999, An Anti-Capitalist Manifesto (2003, The Resources of Critique (2006, Imperialism and Global Political Economy (2009. His most recent book is entitled Deciphering Capital: Marx’s Capital and its Destiny (2014.

  5. Redox Pioneer: Professor Stuart A. Lipton

    Science.gov (United States)

    2013-01-01

    Abstract Professor Stuart A. Lipton Stuart A. Lipton, M.D., Ph.D. is recognized here as a Redox Pioneer because of his publication of four articles that have been cited more than 1000 times, and 96 reports which have been cited more than 100 times. In the redox field, Dr. Lipton is best known for his work on the regulation by S-nitrosylation of the NMDA-subtype of neuronal glutamate receptor, which provided early evidence for in situ regulation of protein activity by S-nitrosylation and a prototypic model of allosteric control by this post-translational modification. Over the past several years, Lipton's group has pioneered the discovery of aberrant protein nitrosylation that may contribute to a number of neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (Lou Gehrig's disease). In particular, the phenotypic effects of rare genetic mutations may be understood to be enhanced or mimicked by nitrosative (and oxidative) modifications of cysteines and thereby help explain common sporadic forms of disease. Thus, Lipton has contributed in a major way to the understanding that nitrosative stress may result from modifications of specific proteins and may operate in conjunction with genetic mutation to create disease phenotype. Lipton (collaborating with Jonathan S. Stamler) has also employed the concept of targeted S-nitrosylation to produce novel neuroprotective drugs that act at allosteric sites in the NMDA receptor. Lipton has won a number of awards, including the Ernst Jung Prize in Medicine, and is an elected fellow of the AAAS. Antioxid. Redox Signal. 19, 757–764. PMID:23815466

  6. Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16

    Science.gov (United States)

    Djoussé, Luc; Knowlton, Beth; Hayden, Michael R.; Almqvist, Elisabeth W.; Brinkman, Ryan R.; Ross, Christopher A.; Margolis, Russel L.; Rosenblatt, Adam; Durr, Alexandra; Dode, Catherine; Morrison, Patrick J.; Novelletto, Andrea; Frontali, Marina; Trent, Ronald J. A.; McCusker, Elizabeth; Gómez-Tortosa, Estrella; Mayo Cabrero, David; Jones, Randi; Zanko, Andrea; Nance, Martha; Abramson, Ruth K.; Suchowersky, Oksana; Paulsen, Jane S.; Harrison, Madaline B.; Yang, Qiong; Cupples, L. Adrienne; Mysore, Jayalakshmi; Gusella, James F.; MacDonald, Marcy E.

    2007-01-01

    Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. A recent genome scan for genetic modifiers of age at onset of motor symptoms (AO) in HD suggests that one modifier may reside in the region close to the HD gene itself. We used data from 535 HD participants of the New England Huntington cohort and the HD MAPS cohort to assess whether AO was influenced by any of the three markers in the 4p16 region: MSX1 (Drosophila homeo box homologue 1, formerly known as homeo box 7, HOX7), Δ2642 (within the HD coding sequence), and BJ56 (D4S127). Suggestive evidence for an association was seen between MSX1 alleles and AO, after adjustment for normal CAG repeat, expanded repeat, and their product term (model P value 0.079). Of the variance of AO that was not accounted for by HD and normal CAG repeats, 0.8% could be attributed to the MSX1 genotype. Individuals with MSX1 genotype 3/3 tended to have younger AO. No association was found between Δ2642 (P=0.44) and BJ56 (P=0.73) and AO. This study supports previous studies suggesting that there may be a significant genetic modifier for AO in HD in the 4p16 region. Furthermore, the modifier may be present on both HD and normal chromosomes bearing the 3 allele of the MSX1 marker. PMID:15029481

  7. High Protein Diet and Huntington's Disease.

    Directory of Open Access Journals (Sweden)

    Chiung-Mei Chen

    Full Text Available Huntington's disease (HD is a neurodegenerative disorder caused by the huntingtin (HTT gene with expanded CAG repeats. In addition to the apparent brain abnormalities, impairments also occur in peripheral tissues. We previously reported that mutant Huntingtin (mHTT exists in the liver and causes urea cycle deficiency. A low protein diet (17% restores urea cycle activity and ameliorates symptoms in HD model mice. It remains unknown whether the dietary protein content should be monitored closely in HD patients because the normal protein consumption is lower in humans (~15% of total calories than in mice (~22%. We assessed whether dietary protein content affects the urea cycle in HD patients. Thirty HD patients were hospitalized and received a standard protein diet (13.7% protein for 5 days, followed by a high protein diet (HPD, 26.3% protein for another 5 days. Urea cycle deficiency was monitored by the blood levels of citrulline and ammonia. HD progression was determined by the Unified Huntington's Disease Rating Scale (UHDRS. The HPD increased blood citrulline concentration from 15.19 μmol/l to 16.30 μmol/l (p = 0.0378 in HD patients but did not change blood ammonia concentration. A 2-year pilot study of 14 HD patients found no significant correlation between blood citrulline concentration and HD progression. Our results indicated a short period of the HPD did not markedly compromise urea cycle function. Blood citrulline concentration is not a reliable biomarker of HD progression.

  8. Huntington disease: Experimental models and therapeutic perspectives

    International Nuclear Information System (INIS)

    Serrano Sanchez, Teresa; Blanco Lezcano, Lisette; Garcia Minet, Rocio; Alberti Amador, Esteban; Diaz Armesto, Ivan and others

    2011-01-01

    Huntington's disease (HD) is a degenerative dysfunction of hereditary origin. Up to date there is not, an effective treatment to the disease which having lapsed 15 or 20 years advances inexorably, in a slow form, toward the total inability or death. This paper reviews the clinical and morphological characteristics of Huntington's disease as well as the experimental models more commonly used to study this disease, having as source the articles indexed in Medline data base, published in the last 20 years. Advantages and disadvantages of all experimental models to reproduce the disease as well as the perspectives to therapeutic assay have been also considered. the consent of outline reported about the toxic models, those induced by neurotoxins such as quinolinic acid, appears to be the most appropriate to reproduce the neuropathologic characteristic of the disease, an genetic models contributing with more evidence to the knowledge of the disease etiology. Numerous treatments ameliorate clinical manifestations, but none of them has been able to stop or diminish the affectations derived from neuronal loss. At present time it is possible to reproduce, at least partially, the characteristics of the disease in experimentation animals that allow therapy evaluation in HD. from the treatment view point, the more promissory seems to be transplantation of no neuronal cells, taking into account ethical issues and factibility. On the other hand the new technology of interference RNA emerges as a potential therapeutic tool for treatment in HD, and to respond basic questions on the development of the disease.

  9. Polycladida from Curaçao and faunistically related regions

    NARCIS (Netherlands)

    Bois-Reymond Marcus, du Eveline; Marcus, Ernst

    1968-01-01

    Professor Dr. DIVA DINIZ CORRÊA, Head of the Department of Zoology of the University of São Paulo, was able to work at the “Caraïbisch Marien-Biologisch Instituut” (Caribbean Marine Biological Institute: Carmabi) at Curaçao from December 1965 to March 1966, thanks to a grant received from the

  10. Ao leitor sem medo

    Directory of Open Access Journals (Sweden)

    José Eisenberg

    2000-05-01

    Full Text Available O texto resenha Ao leitor sem medo, de Renato Janine Ribeiro (Belo Horizonte, UFMG, 1999.This text is a review of Ao leitor sem medo by Renato Janine Ribeiro (Belo Horizonte, UFMG, 1999

  11. O desenvolvimento político em Huntington e Fukuyama Huntington and Fukuyama on political development

    Directory of Open Access Journals (Sweden)

    Natália Nóbrega de Mello

    2010-01-01

    Full Text Available O artigo contrasta as teses de Huntington e Fukuyama sobre desenvolvimento político. As obras analisadas, Ordem política nas sociedades em mudança e O fim da história, inscrevem-se entre duas conjunturas decisivas - 1968 e 1989. Huntington desmontou a equivalência entre desenvolvimento político e modernização e Fukuyama reafirmou a democracia como o destino de todos os países e, desse modo, como o fim da história. Nesta comparação, dois eixos se sobressaem: o contexto de produção das obras e a alternância entre os polos teóricos da democracia e da estabilidade. Procura-se demonstrar como, apesar de reinserir a democracia no desenvolvimento político, a instabilidade continua a ser um foco privilegiado de análise no pensamento de Fukuyama.The article contrasts the theories of Huntington and Fukuyama on political development. The analyzed works, Political order in changing societies and The end of history, fall between two decisive historical moments - in 1968 and 1989. Huntington disassembled the equivalence between political development and modernization; Fukuyama reaffirmed democracy as the destiny of all countries and, as such, it is the end of history. In this comparison, two axes call our attention: the production context of these works and the alternation between the theoreticals poles of democracy and stability. The article shows how, although reenters democracy in the political development theory, instablility remains a prime focus of analysis in Fukuyama's thought.

  12. Professor Igor Yevseyev: In Memoriam Professor Igor Yevseyev: In Memoriam

    Science.gov (United States)

    2012-06-01

    Dear readers and authors, June 3, 2012 will mark five months since Professor Igor Yevseyev, Deputy Editor-in-Chief of both journals Laser Physics and Laser Physics Letters passed away, suddenly and unexpectedly. He was 67. Born in Moscow, he entered one of the world's best schools of physics, Moscow Engineering Physics Institute (MEPhI). With this renowned educational and research institution he bonded an alliance for his entire life, starting as an undergraduate student in the Department of Theoretical Physics and later continued as graduate student, assistant professor, associated professor, and full professor in the same department, a rare accomplishment of a person. All those years he retained the love of his life—the love for physics. He worked tirelessly as a teacher and scholar in this captivating field of knowledge. Professor Yevseyev was one of the founders of the international journal of Laser Physics in 1990, the first academic English language journal published in the former USSR. Later, in 2004, the second journal, Laser Physics Letters was brought to the forum of global laser physics community. The idea behind this new title was Professor Yevseyev's initiative to reach the readers and participants with new pioneering and break-through research results more rapidly. His leadership and indefatigable dedication to the quality of published materials made it possible that this journal reached international recognition in a few short years. Still, in order to attract even more attention of potential contributors and readers, Professor Yevseyev originally proposed to conduct the International Laser Physics Workshop (LPHYS) on the annual basis. Since 1992 the Workshop has been conducted every year, each year in a different country. As in all previous years, Professor Yevseyev was the key organizer of this year's workshop in Calgary, Canada. Sadly, this workshop will take place without him. Editorial Board

  13. Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease

    DEFF Research Database (Denmark)

    Khakh, Baljit S.; Beaumont, Vahri; Cachope, Roger

    2017-01-01

    Astrocytes are abundant within mature neural circuits and are involved in brain disorders. Here, we summarize our current understanding of astrocytes and Huntington's disease (HD), with a focus on correlative and causative dysfunctions of ion homeostasis, calcium signaling, and neurotransmitter...

  14. Wanted: More Squares Among Professors

    Science.gov (United States)

    Fisher, William H.

    1969-01-01

    Professors who see the world and life in a context of sincerely held religious beliefs should be given the same tolerance and understanding which atheists and agnostics used to demand for themselves. (AD)

  15. The College Professor's Professional Liability

    Science.gov (United States)

    Griggs, Walter S.; Rubin, Harvey W.

    1977-01-01

    The growing number of professional liability suits against professors warrants a close examination of the need for and provisions of available insurance coverage. The evolution of tort liability, the question of negligence, and the professional liability policy are discussed. (LBH)

  16. Contribution of Neuroepigenetics to Huntington's Disease.

    Science.gov (United States)

    Francelle, Laetitia; Lotz, Caroline; Outeiro, Tiago; Brouillet, Emmanuel; Merienne, Karine

    2017-01-01

    Unbalanced epigenetic regulation is thought to contribute to the progression of several neurodegenerative diseases, including Huntington's disease (HD), a genetic disorder considered as a paradigm of epigenetic dysregulation. In this review, we attempt to address open questions regarding the role of epigenetic changes in HD, in the light of recent advances in neuroepigenetics. We particularly discuss studies using genome-wide scale approaches that provide insights into the relationship between epigenetic regulations, gene expression and neuronal activity in normal and diseased neurons, including HD neurons. We propose that cell-type specific techniques and 3D-based methods will advance knowledge of epigenome in the context of brain region vulnerability in neurodegenerative diseases. A better understanding of the mechanisms underlying epigenetic changes and of their consequences in neurodegenerative diseases is required to design therapeutic strategies more effective than current strategies based on histone deacetylase (HDAC) inhibitors. Researches in HD may play a driving role in this process.

  17. Destination and source memory in Huntington's disease.

    Science.gov (United States)

    El Haj, Mohamad; Caillaud, Marie; Verny, Christophe; Fasotti, Luciano; Allain, Philippe

    2016-03-01

    Destination memory refers to the recall of the destination of previously relayed information, and source memory refers to the recollection of the origin of received information. We compared both memory systems in Huntington's disease (HD) participants. For this, HD participants and healthy adults had to put 12 items in a black or a white box (destination task), and to extract another 12 items from a blue or a red box (source task). Afterwards, they had to decide in which box each item had previously been deposited (destination memory), and from which box each item had previously been extracted (source memory). HD participants showed poorer source as well as destination recall performance than healthy adults in the proposed tasks. Correlation analysis showed that destination recall was significantly correlated with episodic recall in HD participants. Destination memory impairment in HD participants seems to be considerably influenced by their episodic memory performance. © 2014 The British Psychological Society.

  18. Magnetic biomineralisation in Huntington's disease transgenic mice

    International Nuclear Information System (INIS)

    Beyhum, W; Hautot, D; Dobson, J; Pankhurst, Q A

    2005-01-01

    The concentration levels of biogenic magnetite nanoparticles in transgenic R6/2 Huntington's disease (HD) mice have been investigated, using seven control and seven HD mice each from an 8 week-old litter and from a 12 week-old litter. Hysteresis and isothermal remnant magnetisation data were collected on a SQUID magnetometer, and analysed using a model comprising dia/paramagnetic, ferrimagnetic and superparamagnetic contributions, to extract the magnetite and ferritin concentrations present. It was found that magnetite was present in both superparamagnetic and blocked states. A larger spread and higher concentration of magnetite levels was found in the diseased mice for both the 8 week-old and 12 week-old batches, compared to the controls

  19. Professor Igor Yevseyev: In Memoriam

    International Nuclear Information System (INIS)

    2012-01-01

    Dear readers and authors, June 3, 2012 will mark five months since Professor Igor Yevseyev, Deputy Editor-in-Chief of both journals Laser Physics and Laser Physics Letters passed away, suddenly and unexpectedly. He was 67. Born in Moscow, he entered one of the world's best schools of physics, Moscow Engineering Physics Institute (MEPhI). With this renowned educational and research institution he bonded an alliance for his entire life, starting as an undergraduate student in the Department of Theoretical Physics and later continued as graduate student, assistant professor, associated professor, and full professor in the same department, a rare accomplishment of a person. All those years he retained the love of his life—the love for physics. He worked tirelessly as a teacher and scholar in this captivating field of knowledge. Professor Yevseyev was one of the founders of the international journal of Laser Physics in 1990, the first academic English language journal published in the former USSR. Later, in 2004, the second journal, Laser Physics Letters was brought to the forum of global laser physics community. The idea behind this new title was Professor Yevseyev's initiative to reach the readers and participants with new pioneering and break-through research results more rapidly. His leadership and indefatigable dedication to the quality of published materials made it possible that this journal reached international recognition in a few short years. Still, in order to attract even more attention of potential contributors and readers, Professor Yevseyev originally proposed to conduct the International Laser Physics Workshop (LPHYS) on the annual basis. Since 1992 the Workshop has been conducted every year, each year in a different country. As in all previous years, Professor Yevseyev was the key organizer of this year's workshop in Calgary, Canada. Sadly, this workshop will take place without him. Editorial Board

  20. Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington?s Disease Mouse Model R6/2

    OpenAIRE

    Nielsen, Signe Marie Borch; Hasholt, Lis; N?rrem?lle, Anne; Josefsen, Knud

    2015-01-01

    Huntington?s disease (HD) is a neurodegenerative illness, where selective neuronal loss in the brain caused by expression of mutant huntingtin protein leads to motor dysfunction and cognitive decline in addition to peripheral metabolic changes. In this study we confirm our previous observation of impairment of lactate-based hepatic gluconeogenesis in the transgenic HD mouse model R6/2 and determine that the defect manifests very early and progresses in severity with disease development, indic...

  1. The Universe in a Box: Introduction to the Study of Astronomy in the Initial Formation of Physics Teachers. (Spanish Title: El Universo Representado en Una Caja: Introducción al Estudio de la Astronomía en la Formación Inicial de Profesores de Física.) O Universo Representado em Uma Caixa: Introdução ao Estudo da Astronomia NA Formação Inicial de Professores de Física

    Science.gov (United States)

    Longhini, Marcos Daniel

    2009-07-01

    This is a report of an activity of introduction to the study of Astronomy developed with a group of future Physics teachers at a Brazilian public university. Such activity had the goal of giving privileged emphasis to notions of spatiality, alternative conceptions of the participants and the process of interaction among peers, and consisted of the representation, in a three dimensional space, of the models of the universe that the participants had. The results, which were categorized as miscellaneous, geocentric, heliocentric and acentric models of the universe, were qualitatively analyzed. Analyses of the activity in the perspective of the participants are indicated and additional considerations are made regarding its use as a resource for teaching Astronomy and for teacher training. Este es el informe de una actividad para presentar un estudio introductorio de la Astronomía, desarrollado con una clase de futuros profesores de física en una universidad pública brasileña. Esta actividad tuvo como objetivo centrar las nociones de espacialidad, las concepciones alternativas de los participantes y el proceso de interacción entre pares, y consistió en la representación en un espacio tridimensional, de los modelos del universo que los participantes habían. Los resultados, que se clasificaron en universo miscelania, geocéntrico, heliocéntrico y acentrico, se analizaron cualitativamente. Son identificadas análisis de la actividad por los participantes, e hizo observaciones sobre su uso como recurso para la enseñanza de la astronomía y la formación de docentes. Trata-se do relato de uma atividade de introdução ao estudo da Astronomia, desenvolvida com uma turma de futuros professores de Física, em uma universidade pública brasileira. Tal atividade teve como meta privilegiar noções de espacialidade, as concepções alternativas dos participantes e o processo de interação entre pares e constou da representação, em um espaço tridimensional, dos

  2. Student Evaluations of College Professors: Are Female and Male Professors Rated Differently?

    Science.gov (United States)

    Basow, Susan A.; Silberg, Nancy T.

    1987-01-01

    Over 1,000 undergraduates evaluated 16 male and female professors in terms of teaching effectiveness and sex-typed characteristics. Male students gave female professors significantly poorer ratings than male professors on the six teaching evaluation measures. Female students evaluated female professors less favorably than male professors on three…

  3. Teaching Ethos of Reference Professors

    Directory of Open Access Journals (Sweden)

    Jules Marcel

    2018-03-01

    Full Text Available The present article discusses the teaching ethos of professors who are recognized for their good practice as trainers. The aim of our study is to analyze the influences of such professors’ professional constitution, as well as the explicit and/or tacit teaching knowledge they mobilize in their teaching practices. Based on Shulman, Gauthier, Tardif and Polanyi, we conducted interviews with three professors described by their students as reference. They were also observed in their classes, in the context of an undergraduate program in pedagogy at a public university. Data show similarities between the practices of the investigated professors, as well as a consistent description of their didactics, which is marked by intellective, moral, emotional and behavioral features.

  4. 75 FR 13454 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Science.gov (United States)

    2010-03-22

    ...-AA08 Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY AGENCY: Coast... navigable waters of Huntington Bay, New York due to the annual Fran Schnarr Open Water Championships. The..., ``Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY'' (Docket number USCG...

  5. 75 FR 38710 - Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY

    Science.gov (United States)

    2010-07-06

    ...-AA08 Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY AGENCY: Coast... Regulation on the navigable waters of Huntington Bay, New York due to the annual Fran Schnarr Open Water... ``Special Local Regulation, Fran Schnarr Open Water Championships, Huntington Bay, NY'' in the Federal...

  6. Refletindo sobre a relação professor-aluno em um grupo de professores do Esino Fundamental

    Directory of Open Access Journals (Sweden)

    Antônio dos Santos Andrade

    1999-06-01

    Full Text Available A partir das concepções de Donald Schön sobre a formação do professor como prático reflexivo, os princípios de trabalho com pequenos grupos, baseados nas concepções de J. L Moreno, foram utilizados com o objetivo de facilitar o processo de reflexão sobre suas práticas de sala de aula, com seis professores do Ensino Fundamental. Foram realizados nove encontros de 90 a 120 minutos de duração. Nas discussões, os casos dos alunos mais problemáticos quanto ao seu comportamento foram trazidos pelos professores e analisados pelo grupo a luz das concepções da Pragmática da Comunicação Humana. Como resultado destas discussões, os professores foram levados a considerar os aspectos mais latentes, e portanto significantes, de suas relações com os alunos. Estas reflexões conduziram a uma "resignificação" das mesmas, com efeitos surpreendentes sobre os comportamentos dos alunos.

  7. Changes in mental state and behaviour in Huntington's disease.

    Science.gov (United States)

    Eddy, Clare M; Parkinson, Ellice G; Rickards, Hugh E

    2016-11-01

    Changes in mental state and behaviour have been acknowledged in Huntington's disease since the original monograph in 1872 provided evidence of disinhibition and impaired social cognition. Behavioural problems can manifest before obvious motor symptoms and are frequently the most disabling part of the illness. Although pharmacological treatments are used routinely for psychiatric difficulties in Huntington's disease, the scientific evidence base for their use is somewhat sparse. Moreover, effective treatments for apathy and cognitive decline do not currently exist. Understanding the social cognitive impairments associated with Huntington's disease can assist management, but related therapeutic interventions are needed. Future research should aim to design rating scales for behaviour and mental state in Huntington's disease that can detect change in clinical trials. Generally, communication and understanding of behaviour and mental state in Huntington's would be enhanced by a clear conceptual framework that unifies ideas around movement, cognition, emotion, behaviour, and mental state, reflecting both the experience of the patient and their underlying neuropathology. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Haplotype-based stratification of Huntington's disease.

    Science.gov (United States)

    Chao, Michael J; Gillis, Tammy; Atwal, Ranjit S; Mysore, Jayalakshmi Srinidhi; Arjomand, Jamshid; Harold, Denise; Holmans, Peter; Jones, Lesley; Orth, Michael; Myers, Richard H; Kwak, Seung; Wheeler, Vanessa C; MacDonald, Marcy E; Gusella, James F; Lee, Jong-Min

    2017-11-01

    Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by expansion of a CAG trinucleotide repeat in HTT, resulting in an extended polyglutamine tract in huntingtin. We and others have previously determined that the HD-causing expansion occurs on multiple different haplotype backbones, reflecting more than one ancestral origin of the same type of mutation. In view of the therapeutic potential of mutant allele-specific gene silencing, we have compared and integrated two major systems of HTT haplotype definition, combining data from 74 sequence variants to identify the most frequent disease-associated and control chromosome backbones and revealing that there is potential for additional resolution of HD haplotypes. We have used the large collection of 4078 heterozygous HD subjects analyzed in our recent genome-wide association study of HD age at onset to estimate the frequency of these haplotypes in European subjects, finding that common genetic variation at HTT can distinguish the normal and CAG-expanded chromosomes for more than 95% of European HD individuals. As a resource for the HD research community, we have also determined the haplotypes present in a series of publicly available HD subject-derived fibroblasts, induced pluripotent cells, and embryonic stem cells in order to facilitate efforts to develop inclusive methods of allele-specific HTT silencing applicable to most HD patients. Our data providing genetic guidance for therapeutic gene-based targeting will significantly contribute to the developments of rational treatments and implementation of precision medicine in HD.

  9. REPRESENTAÇÃO SOCIAL DO PROFESSOR SOBRE AS DIFICULDADE DE APRENDIZAGEM DO ALUNO

    Directory of Open Access Journals (Sweden)

    Joana Jesus Silva

    2016-11-01

    Full Text Available O presente trabalho analisa os processos e conteúdos representacionais dos professores de 9 instituições de ensino públicas rurais de um município do Vale do Paraíba Paulista com relação às dificuldades de aprendizagem do aluno. Para este fim, foram realizadas 15 entrevistas com professores do ensino fundamental. Uma análise de conteúdo informatizada de tais entrevistas com o software ALCESTE® revelou 7 classes de discursos, uma delas especificamente ligada ao tema “dificuldade de aprendizagem”. A representação social da dificuldade de aprendizagem para esse grupo de professores revela que os sujeitos atribuem ao próprio aluno e ao seu contexto sócio-econômico-cultural a responsabilidade pelo insucesso, conferindo aos fatores externos a principal causa destas dificuldades. Os professores culpabilizam especialmente as condições de vida do educando e a ausência da família na vida escolar do estudante. Foi possível ainda identificar os processos de objetivação e ancoragem que estão na gênese da representação social da dificuldade de aprendizagem do aluno.

  10. Professors of the New Economy.

    Science.gov (United States)

    Wilson, Robin

    2000-01-01

    Profiles four professors who epitomize the increasing influence of academe on new technology-driven Internet business: a start-up maven, Steven Kaplan; a social psychologist, Michael Ray; a cyberlawyer, David Post; and an e-commerce expert, Andrew B. Whinston. (DB)

  11. Factores protectores frente al consumo de alcohol: concepción de maestros de nivel inicial Fatores protetores frente ao consumo de álcool: percepção de professores de educação básica Protection factors against alcohol consumption as perceived by basic education teachers

    Directory of Open Access Journals (Sweden)

    Juana Beatriz Sigampa

    2005-10-01

    Full Text Available Esta investigación busca comprender la concepción de maestros de nivel inicial sobre los factores protectores frente al consumo de alcohol, basándose en los modelos teóricos de Resiliencia y Promoción de la Salud. De enfoque metodológico cualitativo, exploratorio, aplica entrevistas semi-estructuradas y observación no estructurada a una muestra de 25 maestras. Del análisis de contenido de los datos surgen tres categorías temáticas: Significado de Alcohol/Alcoholismo - interpretado como sustancia nociva y situación problema socio-cultural -; La Escuela como Espacio de Protección Frente al Consumo de Alcohol; El Maestro como Agente de Protección. Se asocia protección con informar hasta cuidar. El maestro entiende su función desde orientador hasta consejero/protector, para la cual, mayoritariamente, no se siente preparado fundamentándose en déficits psicopedagógicos, cognocistivos, jurídico-legales y por propios prejuicios sobre alcoholismo. Los resultados confirman los presupuestos de la investigación relativos al maestro y contexto escolar.O objetivo desta pesquisa é entender a percepção de professores de educação básica sobre os fatores que protegem contra o consumo de álcool. Foi adotada uma metodologia qualitativa do tipo exploratório, com entrevistas semi-estruturadas e observação não-estruturada aplicadas a uma amostra de 25 professoras. A análise de conteúdo dos dados levantou três categorias temáticas: Significado de Álcool/Alcoolismo; A Escola como Espaço de Proteção contra o Consumo de Álcool; o Professor como Agente de Proteção. O primeiro é interpretado como uma substância nociva e uma situação problema sócio-cultural. A proteção é associada com informar, comunicar, educar, ou cuidar. Portanto, o professor compreende sua função como cobrindo desde orientador até conselheiro ou protetor. A maioria não se sente preparada para desempenhá-la, fundamentando-se em déficits psicopedag

  12. Perda da voz em professores e não professores Voice loss in teachers and non-teachers

    Directory of Open Access Journals (Sweden)

    Kelly Park

    2009-01-01

    Full Text Available OBJETIVO: Verificar a percepção de professores e não-professores sobre as implicações de uma eventual perda de voz. MÉTODOS: Participaram 205 indivíduos sendo 105 professores e 100 não professores entre 23 a 65 anos, 106 mulheres e 99 homens. Foi aplicado um questionário contendo quatro perguntas referentes a uma eventual perda de visão, audição, voz e deambulação e o grau de impacto inferido (de 0 a 4. RESULTADOS: Para o grupo de professores, não enxergar gerou o maior impacto negativo (média de 3,8, seguido por não andar (média de 3,7, não ter voz (média de 3,7 e não ouvir (média de 3,6. Para o grupo de não-professores, não enxergar também gerou o maior impacto negativo (média de 3,4, seguido por não andar (média de 3,0; não ouvir (média de 2,2 e não ter voz (média de 2,0. Em relação ao maior impacto de uma eventual perda da voz, professores indicaram prejuízos no trabalho, relacionamento social e atividades rotineiras e, no grupo de não professores, nas atividades rotineiras, trabalho, relacionamento social e manifestações das emoções. CONCLUSÕES: Os professores valorizam sua voz de modo diverso dos não-professores e ambos os grupos avaliam a perda da voz como algo que não acarreta consequências negativas. Apesar de o professor perceber mais o impacto de um eventual problema de voz do que o não-professor, os sentimentos em relação à perda da voz foram muito semelhantes nos dois grupos.PURPOSE: To investigate teachers' and non-teachers' perception regarding the implications of an eventual loss of voice. METHODS: Participated in the study 205 individuals (106 women and 99 men, 105 teachers and 100 non-teachers, with ages varying from 23 to 65 years old. The participants were asked to answer a questionnaire with four questions regarding an eventual loss of vision, hearing, voice and deambulation, and the inferred impact degree (from 0 to 4. RESULTS: For the teachers group, not being able to see

  13. As interações professor-professor na co-construção dos projetos pedagógicos na escola

    Directory of Open Access Journals (Sweden)

    Mírian Raposo

    Full Text Available A qualidade das interações entre professores é uma realidade da cultura escolar de fundamental importância para o desenvolvimento do seu projeto pedagógico e do currículo vivido pelo aluno. Arquitetado nos pressupostos teóricos da abordagem sociocultural construtivista, este trabalho teve como objetivo investigar os processos co-construtivos presentes nas interações professor-professor, fundamentais para a elaboração e execução dos projetos vividos em uma escola pública de formação de professores do Distrito Federal. Participaram do estudo os 23 professores do curso normal, a coordenadora e o diretor. Procedimentos de observação participante das atividades pedagógicas de planejamento e execução de projetos e entrevista semi-estruturada com 10 desses participantes foram realizados em um período de três meses. A análise dos resultados focalizou (1 relações de confiança (2 interdependência indivíduo-grupo e (3 liderança. Estas categorias foram cruciais para o alcance dos objetivos estabelecidos na escola. Considera-se que estas são contribuições importantes da Psicologia aos cursos de formação inicial e continuada de professores.

  14. Embodied emotion impairment in Huntington's Disease.

    Science.gov (United States)

    Trinkler, Iris; Devignevielle, Sévérine; Achaibou, Amal; Ligneul, Romain V; Brugières, Pierre; Cleret de Langavant, Laurent; De Gelder, Beatrice; Scahill, Rachael; Schwartz, Sophie; Bachoud-Lévi, Anne-Catherine

    2017-07-01

    Theories of embodied cognition suggest that perceiving an emotion involves somatovisceral and motoric re-experiencing. Here we suggest taking such an embodied stance when looking at emotion processing deficits in patients with Huntington's Disease (HD), a neurodegenerative motor disorder. The literature on these patients' emotion recognition deficit has recently been enriched by some reports of impaired emotion expression. The goal of the study was to find out if expression deficits might be linked to a more motoric level of impairment. We used electromyography (EMG) to compare voluntary emotion expression from words to emotion imitation from static face images, and spontaneous emotion mimicry in 28 HD patients and 24 matched controls. For the latter two imitation conditions, an underlying emotion understanding is not imperative (even though performance might be helped by it). EMG measures were compared to emotion recognition and to the capacity to identify and describe emotions using alexithymia questionnaires. Alexithymia questionnaires tap into the more somato-visceral or interoceptive aspects of emotion perception. Furthermore, we correlated patients' expression and recognition scores to cerebral grey matter volume using voxel-based morphometry (VBM). EMG results replicated impaired voluntary emotion expression in HD. Critically, voluntary imitation and spontaneous mimicry were equally impaired and correlated with impaired recognition. By contrast, alexithymia scores were normal, suggesting that emotion representations on the level of internal experience might be spared. Recognition correlated with brain volume in the caudate as well as in areas previously associated with shared action representations, namely somatosensory, posterior parietal, posterior superior temporal sulcus (pSTS) and subcentral sulcus. Together, these findings indicate that in these patients emotion deficits might be tied to the "motoric level" of emotion expression. Such a double

  15. ICT Use by Journalism Professors in Colombia

    Science.gov (United States)

    Hung, Elias Said

    2011-01-01

    This article analyses how journalism professors at Colombian universities use information and communications technologies (ICT) in their teaching. Survey data was obtained during the first trimester of 2009 from 63 professors in journalism departments and from a total of 865 professors who are affiliated with journalism departments at 29…

  16. β-Defensin genomic copy number does not influence the age of onset in Huntington's Disease.

    Science.gov (United States)

    Vittori, Angelica; Orth, Michael; Roos, Raymund A C; Outeiro, Tiago F; Giorgini, Flaviano; Hollox, Edward J

    2013-01-01

    Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the abnormal expansion of a CAG triplet repeat tract in the huntingtin gene. While the length of this CAG expansion is the major determinant of the age of onset (AO), other genetic factors have also been shown to play a modulatory role. Recent evidence suggests that neuroinflammations is a pivotal factor in the pathogenesis of HD, and that targeting this process may have important therapeutic ramifications. The human β-defensin 2 (hBD2)- encoded by DEFB4- is an antimicrobial peptide that exhibits inducible expression in astrocytes during inflammation and is an important regulator of innate and adaptive immune response. Therefore, DEFB4 may contribute to the neuroinflammatory processes observed in HD. In this study we tested the hypothesis that copy number variation (CNV) of the β-defensin region, including DEFB4, modifies the AO in HD. We genotyped β-defensin CNV in 490 HD individuals using the paralogue ratio test and found no association between β-defensin CNV and onset of HD. We conclude that it is unlikely that DEFB4 plays a role in HD pathogenesis.

  17. An improved assay for the determination of Huntington`s disease allele size

    Energy Technology Data Exchange (ETDEWEB)

    Reeves, C.; Klinger, K.; Miller, G. [Intergrated Genetics, Framingham, MA (United States)

    1994-09-01

    The hallmark of Huntington`s disease (HD) is the expansion of a polymorphic (CAG)n repeat. Several methods have been published describing PCR amplification of this region. Most of these assays require a complex PCR reaction mixture to amplify this GC-rich region. A consistent problem with trinucleotide repeat PCR amplification is the presence of a number of {open_quotes}stutter bands{close_quotes} which may be caused by primer or amplicon slippage during amplification or insufficient polymerase processivity. Most assays for HD arbitrarily select a particular band for diagnostic purposes. Without a clear choice for band selection such an arbitrary selection may result in inconsistent intra- or inter-laboratory findings. We present an improved protocol for the amplification of the HD trinucleotide repeat region. This method simplifies the PCR reaction buffer and results in a set of easily identifiable bands from which to determine allele size. HD alleles were identified by selecting bands of clearly greater signal intensity. Stutter banding was much reduced thus permitting easy identification of the most relevant PCR product. A second set of primers internal to the CCG polymorphism was used in selected samples to confirm allele size. The mechanism of action of N,N,N trimethylglycine in the PCR reaction is not clear. It may be possible that the minimal isostabilizing effect of N,N,N trimethylglycine at 2.5 M is significant enough to affect primer specificity. The use of N,N,N trimethylglycine in the PCR reaction facilitated identification of HD alleles and may be appropriate for use in other assays of this type.

  18. Professor dr hab. Maria Lisiewska

    Directory of Open Access Journals (Sweden)

    Małgorzata Stasińska

    2015-08-01

    Full Text Available The article presents the biography and scientific achievements of Professor Maria Lisiewska. She earned master’s degree and Ph.D. in natural sciences from Adam Mickiewicz University in Poznań. After earning her doctoral degree, she stayed at Adam Mickiewicz University in Poznań and conducted her thrilling research on mycology and taught until now. Prof. Maria Lisiewska is an author of many books, articles, and other scholarly reports.

  19. Remifentanil in a patient with Huntington's chorea - case report ...

    African Journals Online (AJOL)

    Relatively few published case reports related to the anaesthetic management of Huntington's chorea (HC) exist. At the time of surgery no publications were found related to remifentanil's use in patients with HC. This case report describes the management of a confirmed HC patient requiring urgent decompression of a spinal ...

  20. PSYCHIATRIC ASPECTS OF HUNTINGTON DISEASE – CASE REPORTS

    Directory of Open Access Journals (Sweden)

    Mirela Batta

    2004-04-01

    Full Text Available Background. Huntington disease occurrs rarely, it can be encountered not only by neurologists and psychiatrists but also by other medical practitioners. Its characteristic features are involuntary movements, cognitive disorders and gradual development of dementia. Diagnosis is given on the basis of these clinical features, positive familial anamnesis, with the laboratory exclusion of other neuropsychiatric diseases and with the help of neuroimaging methods (in particular NMR. The disease can be only confirmed by means of genetic analysis.Patients and methods. In this article, four cases of patients with Huntington disease and diverse psychiatric disorders that were hospitalised at the psychiatric department of the Maribor General Hospital between October 2002 and March 2003 are described. All the patients fulfilled the valid criteria for the diagnosis of Huntington disease. However, they differed according to their accompanying psychiatric psychopathology, age and social problems.Conclusions. The purpose of this article is to draw attention to different psychiatric symptoms and clinical manifestations of Huntington disease that are often misleading in the diagnostic process. In addition, exigency of early diagnostics, guidelines for referrals to genetic testing and psychiatric monitoring of these patients are emphasised.

  1. Ethical issues and Huntington's disease | Kromberg | South African ...

    African Journals Online (AJOL)

    The practice of genetic counselling gives rise to many ethical dilemmas, and counsellors need to be familiar with the principles of biomedical ethics. The primary principles include respect for autonomy, beneficence, non-maleficence and justice. A case of identical twins at 50% risk for Huntington's disease, in which only one ...

  2. The emotional experiences of family carers in Huntington disease.

    Science.gov (United States)

    Williams, Janet K; Skirton, Heather; Paulsen, Jane S; Tripp-Reimer, Toni; Jarmon, Lori; McGonigal Kenney, Meghan; Birrer, Emily; Hennig, Bonnie L; Honeyford, Joann

    2009-04-01

    This paper is a report of a study conducted to examine the emotional experience of caregiving by family carers of people with Huntington disease and to describe strategies they used to deal with that experience. Huntington disease, commonly diagnosed in young to middle adulthood, is an inherited single gene disorder involving loss of cognitive, motor and neuropsychiatric function. Many family members become caregivers as well as continuing as parents and wage earners. The emotional aspects of caregiving contribute to mental health risks for family members. Focus groups were conducted with 42 adult carers of people with Huntington disease in four United States and two Canadian Huntington disease centers between 2001 and 2005. Data were analyzed through descriptive coding and thematic analysis. All participants reported multiple aspects of emotional distress. Being a carer was described as experiencing disintegration of one's life. Carers attempted to cope by seeking comfort from selected family members, anticipating the time when the care recipient had died and/or using prescription medications. Spousal carers were distressed by the loss of their relationship with their spouse and dealt with this by no longer regarding the person as an intimate partner. Carers were concerned about the disease risk for children in their families and hoped for a cure. Emotional distress can compromise the well-being of family carers, who attempt to maintain multiple roles. Nurses should monitor carer mental health, identify sources of emotional distress and support effective strategies used by carers to mediate distress.

  3. Materiais didáticos nas aulas de música : um survey com professores da Rede Municipal de Ensino de Porto Alegre - RS

    OpenAIRE

    Fernanda de Assis Oliveira

    2005-01-01

    Esta pesquisa teve como objetivo investigar as concepções que fundamentam o uso de materiais didáticos pelos professores de música em suas práticas pedagógico-musicais. Mais especificamente buscou identificar o que os professores consideram materiais didáticos, mapear os tipos de materiais didáticos utilizados pelos professores de música, identificar os critérios que fundamentam a seleção dos materiais didáticos, mapear o acesso aos materiais didáticos, analisar a opinião dos professores sobr...

  4. Semantic, phonologic, and verb fluency in Huntington's disease

    Directory of Open Access Journals (Sweden)

    Mariana Jardim Azambuja

    Full Text Available Abstract Verbal fluency tasks have been identified as important indicators of executive functioning impairment in patients with frontal lobe dysfunction. Although the usual evaluation of this ability considers phonologic and semantic criteria, there is some evidence that fluency of verbs would be more sensitive in disclosing frontostriatal physiopathology since frontal regions primarily mediate retrieval of verbs. Huntington's disease usually affects these circuitries. Objective: To compare three types of verbal fluency task in the assessment of frontal-striatal dysfunction in HD subjects. Methods: We studied 26 Huntington's disease subjects, divided into two subgroups: mild (11 and moderate (15 along with 26 normal volunteers matched for age, gender and schooling, for three types of verbal fluency: phonologic fluency (F-A-S, semantic fluency and fluency of verbs. Results: Huntington's disease subjects showed a significant reduction in the number of words correctly generated in the three tasks when compared to the normal group. Both controls and Huntington's disease subjects showed a similar pattern of decreasing task performance with the greatest number of words being generated by semantic elicitation followed by verbs and lastly phonologic criteria. We did not find greater production of verbs compared with F-A-S and semantic conditions. Moreover, the fluency of verbs distinguished only the moderate group from controls. Conclusion: Our results indicated that phonologic and semantic fluency can be used to evaluate executive functioning, proving more sensitive than verb fluency. However, it is important to point out that the diverse presentations of Huntington's disease means that an extended sample is necessary for more consistent analysis of this issue.

  5. Major Superficial White Matter Abnormalities in Huntington's Disease

    Science.gov (United States)

    Phillips, Owen R.; Joshi, Shantanu H.; Squitieri, Ferdinando; Sanchez-Castaneda, Cristina; Narr, Katherine; Shattuck, David W.; Caltagirone, Carlo; Sabatini, Umberto; Di Paola, Margherita

    2016-01-01

    Background: The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to Huntington's disease processes. Methods: Structural MRI data from 25 Pre-symptomatic subjects, 24 Huntington's disease patients and 49 healthy controls was run through a cortical pattern-matching program. The surface corresponding to the white matter directly below the cortical gray matter was then extracted. Individual subject's Diffusion Tensor Imaging (DTI) data was aligned to their structural MRI data. Diffusivity values along the white matter surface were then sampled at each vertex point. DTI measures with high spatial resolution across the superficial white matter surface were then analyzed with the General Linear Model to test for the effects of disease. Results: There was an overall increase in the axial and radial diffusivity across much of the superficial white matter (p < 0.001) in Pre-symptomatic subjects compared to controls. In Huntington's disease patients increased diffusivity covered essentially the whole brain (p < 0.001). Changes are correlated with genotype (CAG repeat number) and disease burden (p < 0.001). Conclusions: This study showed broad abnormalities in superficial white matter even before symptoms are present in Huntington's disease. Since, the superficial white matter has a unique microstructure and function these abnormalities suggest it plays an important role in the disease. PMID:27242403

  6. Professor

    DEFF Research Database (Denmark)

    Hauggaard-Nielsen, Henrik

    2017-01-01

    DEBAT: Land og by hænger uløseligt sammen - både i forhold til fødevareproduktion og -distribuering – men også i forhold til vores fælles natur. Når vi bor i byerne, er vi tæt forbundet og afhængige af de tjenester, som landbruget bidrager med – fødevarer, sikring af rent grundvand, bioenergi, re...

  7. professores

    Directory of Open Access Journals (Sweden)

    Sandra Isabel Rodrigues Magalhães

    2006-01-01

    Full Text Available The development of classroom practices focused on scientific literacy as animportant outcome of schooling forces the re-thinking of science teacher’sformation. In this sense, this paper reports a study which involved theconception, development, implement and evaluation of an in-service program(IP focused on the Science — Technology — Society (STS education alongwith critical thinking (CT [STS/CT]. From the obtained results it was concludedthat the in-service program contributed for the teachers to (reconstructconceptions about Science, Technology and Society, to (reconstructknowledge related to the STS orientation and critical thinking and to promotetheir pre-disposition to implement STS/CTdidactic and pedagogic practices

  8. Tecnologias e professores de Química: um programa brasileiro de desenvolvimento profissional

    Directory of Open Access Journals (Sweden)

    Marcelo Prado Amaral-Rosa

    2017-01-01

    Full Text Available O setor educacional é uma das esferas sociais afetadas diretamente pelas tecnologias digitais. Destinar atenção aos caminhos tomados por tais aparatos é vital para compreender os próprios processos educacionais. Nessa situação, enquadra-se a formação de professores. Assim, o objetivo geral é apresentar as nuances gerais do Programa de Desenvolvimento Profissional para Professores com a finalidade de contextualizar uma estratégia inovadora de formação de professores da rede básica pública de educação a partir das ações formativas desenvolvidas na área de Química. O programa foi ofertado pelo governo brasileiro aos professores da educação básica por meio de um acordo de cooperação internacional entre Brasil e Portugal. As formações ocorreram na Universidade do Porto e na Universidade de Aveiro. Foram ofertadas 175 vagas para professores de todas as regiões do Brasil nas áreas de Língua Portuguesa, Pedagogia, Física, Matemática e Química. A área de Química foi a única que ocorreu em ambas as instituições parceiras, sendo acompanhadas in loco. Percebe-se que o conhecimento por parte da comunidade de professores e pesquisadores sobre a ocorrência dessa formação ofertada pelo governo brasileiro é praticamente inexistente, assim faz-se se suma importância a divulgação dos contextos de ocorrência da mesma, tendo enquanto macro destaque a valorização dos professores da rede pública nacional.

  9. Síndrome de burn-out e identidade do professor universitário

    OpenAIRE

    Rosângela Aparecida Cassiolato

    2010-01-01

    Resumo: Esta pesquisa teve por objetivo conhecer o processo de desenvolvimento da identidade do professor submetido a condições objetivas que favorecem o desencadeamento da síndrome de burn-out. Procuramos identificar os componentes da síndrome e estabelecer a relação entre o desenvolvimento da síndrome e o exercício profissional, analisar o significado atribuído pelo professor ao seu desempenho como parte constituinte de sua identidade e os efeitos do burn-out no trabalho acadêmico. Particip...

  10. Factor analysis of the hospital anxiety and depression scale among a Huntington's disease population

    DEFF Research Database (Denmark)

    Dale, Maria; Maltby, John; Martucci, Rossana

    2015-01-01

    INTRODUCTION: Depression and anxiety are common in Huntington's disease, a genetic neurodegenerative disorder. There is a need for measurement tools of mood to be validated within a Huntington's disease population. The current study aimed to analyze the factor structure of the Hospital Anxiety...... and Depression Scale in Huntington's disease. METHODS: Data from the European Huntington's Disease Network study REGISTRY 3 were used to undertake a factor analysis of the scale among a sample of 492 Huntington's disease mutation carriers. The sample was randomly divided into two equal subsamples...... support for an eight-item version of the scale to be used as a measure of general distress within Huntington's disease populations. © 2015 International Parkinson and Movement Disorder Society....

  11. Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease

    DEFF Research Database (Denmark)

    Dale, Maria; Maltby, John; Shimozaki, Steve

    2016-01-01

    OBJECTIVE: Depression and anxiety significantly affect morbidity in Huntington's disease. Mice. models of Huntington's disease have identified sex differences in mood-like behaviours that vary across disease lifespan, but this interaction has not previously been explored in humans with Huntington......'s disease. However, among certain medical populations, evidence of sex differences in mood across various disease stages has been found, reflecting trends among the general population that women tend to experience anxiety and depression 1.5 to 2 times more than men. The current study examined whether...... disease stage and sex, either separately or as an interaction term, predicted anxiety and depression in Huntington's disease. METHODS: A cross-sectional study of REGISTRY data involving 453 Huntington's disease participants from 12 European countries was undertaken using the Hospital Anxiety...

  12. 'Supermentoring' of assistant professors' teaching

    DEFF Research Database (Denmark)

    Lauridsen, Ole

    Aarhus University offers a mandatory pedagogical training program for assistant professors, required in order to obtain tenure at a Danish university. At Business and Social Sciences, this program is supplemented by voluntary observation and (first of all formative) supervision of the assistant...... professors’ teaching practice. This offer is given is (i) because many young university teachers face problems putting pedagogical theory into practice – even though the program mentioned is practice-oriented, and (ii) because many of them (partly due to (i)) lack self-confidence as to teaching...

  13. Entrevista com professor Bertrand Badie

    OpenAIRE

    Mere Marques Aveiro, Thais

    2015-01-01

    Bertrand Badie é cientista político, professor na Sciences Po, Paris, pesquisador do CERI (Centro de Estudos e Pesquisas Internacionais), codiretor da coleção L’etat du monde, publicada anualmente desde 2010 e coeditor da Enciclopédia Internacional de Ciência Política. Entre 2002 e 2005, foi Diretor do Centro de Estudos Internacionais sobre a paz e resoluções de conflitos. Por dez anos (1994 –2003), foi Diretor das publicações da Sciences Po.Desde 2000, ministra o Curso Espaço Mundial que, a ...

  14. Interview with Professor Mark Wilcox.

    Science.gov (United States)

    Wilcox, Mark

    2016-08-01

    Mark Wilcox speaks to Georgia Patey, Commissioning Editor: Professor Mark Wilcox is a Consultant Microbiologist and Head of Microbiology at the Leeds Teaching Hospitals (Leeds, UK), the Professor of Medical Microbiology at the University of Leeds (Leeds, UK), and is the Lead on Clostridium difficile and the Head of the UK C. difficile Reference Laboratory for Public Health England (PHE). He was the Director of Infection Prevention (4 years), Infection Control Doctor (8 years) and Clinical Director of Pathology (6 years) at the Leeds Teaching Hospitals. He is Chair of PHE's Rapid Review Panel (reviews utility of infection prevention and control products for National Health Service), Deputy Chair of the UK Department of Health's Antimicrobial Resistance and Healthcare Associated Infection Committee and a member of PHE's HCAI/AR Programme Board. He is a member of UK/European/US working groups on C. difficile infection. He has provided clinical advice as part of the FDA/EMA submissions for the approval of multiple novel antimicrobial agents. He heads a healthcare-associated infection research team at University of Leeds, comprising approximately 30 doctors, scientists and nurses; projects include multiple aspects of C. difficile infection, diagnostics, antimicrobial resistance and the clinical development of new antimicrobial agents. He has authored more than 400 publications, and is the coeditor of Antimicrobial Chemotherapy (5th/6th/7th Editions, 15 December 2007).

  15. Huntington disease: a case study of early onset presenting as depression.

    Science.gov (United States)

    Duesterhus, Pia; Schimmelmann, Benno Graf; Wittkugel, Oliver; Schulte-Markwort, Michael

    2004-10-01

    Huntington disease is a dominantly inherited, neurodegenerative disease characterized by choreiform movement disturbances and dementia, usually with adult onset. The rare juvenile-onset Huntington disease differs from the adult phenotype. A case presenting twice, at age 10 with all the signs of a major depression and age 14 with mutism and rigidity, is reported. Meanwhile, the father developed the adult variant of Huntington disease. The boy's diagnosis was confirmed by molecular genetic analysis and magnetic resonance imaging. It is important to be aware of hereditary conditions such as Huntington disease and to provide family counseling before genetic testing and after the diagnosis is confirmed.

  16. The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere

    International Nuclear Information System (INIS)

    Doggett, N.A.; Cheng, J.F.; Smith, C.L.; Cantor, C.R.

    1989-01-01

    The genetic defect responsible for Huntington disease was originally localized near the tip of the short arm of chromosome 4 by genetic linkage to the locus D4S10. Several markers closer to Huntington disease have since been isolated, but these all appear to be proximal to the defect. A physical map that extends from the most distal of these loci, D4S90, to the telomere of chromosome 4 was constructed. This map identifies at least two CpG islands as markers for Huntington disease candidate genes and places the most likely location of the Huntington disease defect remarkably close (within 325 kilobases) to the telomere

  17. Psychodynamic theory and counseling in predictive testing for Huntington's disease.

    Science.gov (United States)

    Tassicker, Roslyn J

    2005-04-01

    This paper revisits psychodynamic theory, which can be applied in predictive testing counseling for Huntington's Disease (HD). Psychodynamic theory has developed from the work of Freud and places importance on early parent-child experiences. The nature of these relationships, or attachments are reflected in adult expectations and relationships. Two significant concepts, identification and fear of abandonment, have been developed and expounded by the psychodynamic theorist, Melanie Klein. The processes of identification and fear of abandonment can become evident in predictive testing counseling and are colored by the client's experience of growing up with a parent affected by Huntington's Disease. In reflecting on family-of-origin experiences, clients can also express implied expectations of the future, and future relationships. Case examples are given to illustrate the dynamic processes of identification and fear of abandonment which may present in the clinical setting. Counselor recognition of these processes can illuminate and inform counseling practice.

  18. Family caregivers' views on coordination of care in Huntington's disease

    DEFF Research Database (Denmark)

    Røthing, Merete; Malterud, Kirsti; Frich, Jan C

    2015-01-01

    BACKGROUND: Collaboration between family caregivers and health professionals in specialised hospitals or community-based primary healthcare systems can be challenging. During the course of severe chronic disease, several health professionals might be involved at a given time, and the patient......'s illness may be unpredictable or not well understood by some of those involved in the treatment and care. AIM: The aim of this study was to explore the experiences and expectations of family caregivers for persons with Huntington's disease concerning collaboration with healthcare professionals. METHODS......: To shed light on collaboration from the perspectives of family caregivers, we conducted an explorative, qualitative interview study with 15 adult participants experienced from caring for family members in all stages of Huntington's disease. Data were analysed with systematic text condensation, a cross...

  19. Caregiver roles in families affected by Huntington's disease

    DEFF Research Database (Denmark)

    Røthing, Merete; Malterud, Kirsti; Frich, Jan C

    2013-01-01

    AIM: The objective of this study was to explore family caregivers' experiences with the impact of Huntington's disease (HD) on the family structure and roles in the family. METHODOLOGY: We interviewed 15 family caregivers in families affected by HD, based on a semi-structured interview guide...... for impairments by taking on adult responsibilities, and in some families, a child had the role as main caregiver. The increasing need for care could cause conflicts between the role as family member and family caregiver. The burden of care within the family could fragment and isolate the family. CONCLUSIONS......: Huntington's disease has a major impact on family systems. Caregiver roles are shaped by impairments in the affected family member and corresponding dynamic adoption and change in roles within the family. Making assessments of the family structure and roles, professionals may understand more about how...

  20. Striatal grafts in a rat model of Huntington's disease

    DEFF Research Database (Denmark)

    Guzman, R; Meyer, M; Lövblad, K O

    1999-01-01

    Survival and integration into the host brain of grafted tissue are crucial factors in neurotransplantation approaches. The present study explored the feasibility of using a clinical MR scanner to study striatal graft development in a rat model of Huntington's disease. Rat fetal lateral ganglionic...... time-points graft location could not be further verified. Measures for graft size and ventricle size obtained from MR images highly correlated with measures obtained from histologically processed sections (R = 0.8, P fetal rat lateral ganglionic...

  1. Challenges of Huntington's disease and quest for therapeutic biomarkers

    Czech Academy of Sciences Publication Activity Database

    Kotrčová, Eva; Jarkovská, Karla; Valeková, Ivona; Žižková, Martina; Motlík, Jan; Gadher, S. J.; Kovářová, Hana

    2015-01-01

    Roč. 9, 1-2 (2015), s. 147-158 ISSN 1862-8346 R&D Projects: GA MŠk ED2.1.00/03.0124; GA TA ČR(CZ) TA01011466 Institutional support: RVO:67985904 Keywords : HD biomarkers * Huntington´s disease * Huntingtin neurotoxicity * Huntingtin pathogenesis Subject RIV: FH - Neurology Impact factor: 2.959, year: 2015

  2. Professor Gender, Age, and "Hotness" in Influencing College Students' Generation and Interpretation of Professor Ratings

    Science.gov (United States)

    Sohr-Preston, Sara L.; Boswell, Stefanie S.; McCaleb, Kayla; Robertson, Deanna

    2016-01-01

    A sample of 230 undergraduate psychology students rated their expectations of a bogus professor (who was randomly designated a man or woman and "hot" versus "not hot") based on ratings and comments found on RateMyProfessors.com. Five professor qualities were derived using principal components analysis: dedication,…

  3. Observations on Professor Hayek's Plan

    Directory of Open Access Journals (Sweden)

    Ludwig von Mises

    2009-01-01

    Full Text Available This memorandum was written at the request of Henry Hazlitt to provide Mises’s comments on and concerns about F.A. Hayek’s initial proposals for what became the Mont Pèlerin Society. Mises stresses that those who favor liberty and freedom and oppose totalitarianism must also oppose interventionism. The memo argues that those who fought and lost against the rising tide of totalitarianism at the turn of the 20th Century lost their battles because they settled for middle-of-the-road policies that conceded considerable ground to the socialists. The weak point in Professor Hayek’s plan is that it relies upon the cooperation of many men who are today’s middle-of-the-roaders. As interventionists, they may not be the hoped-for intellectual pioneers to inspire people to build a freer world.

  4. Professor Camillo Negro's Neuropathological Films.

    Science.gov (United States)

    Chiò, Adriano; Gianetto, Claudia; Dagna, Stella

    2016-01-01

    Camillo Negro, Professor in Neurology at the University of Torino, was a pioneer of scientific film. From 1906 to 1908, with the help of his assistant Giuseppe Roasenda and in collaboration with Roberto Omegna, one of the most experienced cinematographers in Italy, he filmed some of his patients for scientific and educational purposes. During the war years, he continued his scientific film project at the Military Hospital in Torino, filming shell-shocked soldiers. In autumn 2011, the Museo Nazionale del Cinema, in partnership with the Faculty of Neurosciences of the University of Torino, presented a new critical edition of the neuropathological films directed by Negro. The Museum's collection also includes 16 mm footage probably filmed in 1930 by Doctor Fedele Negro, Camillo's son. One of these films is devoted to celebrating the effects of the so-called "Bulgarian cure" on Parkinson's disease.

  5. PIBID – PRIMORDIAL PARA A FORMAÇÃO DE PROFESSORES

    Directory of Open Access Journals (Sweden)

    Rafael Dias Rios de Souza

    2016-12-01

    Full Text Available Resumo - Realizamos nesse artigo, reflexões necessárias para as compreensões e os significados relativos ao Programa de Bolsa de Iniciação à Docência (PIBID, cujo objetivo é o de contribuir de maneira significativa para a formação inicial de professores de História. Constatamos que esse programa é compreendido como um espaço que possibilita a integração entre universidade-escola, oportunizando aos futuros professores, o entendimento e a análise sobre a profissão docente e a realidade escolar. Isso ocorre por meio do desenvolvimento de temáticas que priorizam a inserção de diferentes materiais e abordagens didáticas no ensino de história, visando a renovação nesse campo do conhecimento.

  6. Superdotação/altas habilidades percebidas por pais e professores do ensino fundamental, nível I

    Directory of Open Access Journals (Sweden)

    Nathalya Elizabeth Ferrer Ubeda

    2017-11-01

    Full Text Available As políticas educacionais de inclusão propõem medidas que garantem a participação e desenvolvimento de estudantes com superdotação/altas habilidades, todavia, há um grande desafio no que tange à sua identificação. A realização deste estudo objetivou identificar a percepção de pais e professores quanto às características de superdotação/altas habilidades de seus filhos e alunos. O estudo foi realizado no Ensino Fundamental, Nível I, de uma cidade de pequeno porte no estado de São Paulo. Utilizou-se questionários para pais e professores a fim de realizar coleta de informações. A análise dos dados revelou que os pais demonstraram grandes expectativas quanto ao potencial de seus filhos, enquanto que os professores foram mais ponderados ao escolher os indicadores referentes ao potencial de seus alunos. Ambos apresentaram conhecimento superficial quanto ao assunto e os professores fizeram poucas indicações no item Criatividade, elemento indispensável no processo, pois envolve originalidade de pensamento na solução de problemas.

  7. The Professors behind the MOOC Hype

    Science.gov (United States)

    Kolowich, Steve

    2013-01-01

    The largest-ever survey of professors who have taught MOOCs, or massive open online courses, shows that the process is time-consuming, but, according to the instructors, often successful. Nearly half of the professors felt their online courses were as rigorous academically as the versions they taught in the classroom. The survey, conducted by "The…

  8. Professor Nukem - et eksperiment med oplevelsesbaseret forskningsformidling

    DEFF Research Database (Denmark)

    Sandvik, Kjetil; Thorhauge, Anne Mette

    2007-01-01

    Professor Nukem er resultatet af et forskningsprojekt om oplevelsesbaseret forskningsformidling der har form som et computerspil med tilhørende website, hvor brugeren interaktivt kan engagere sig i forskning omkring sociale og kulturelle aspekter ved computerspil. Professor Nukem kan spilles på...

  9. Professor Kodi Husimi promoted accelerator projects

    International Nuclear Information System (INIS)

    Kikuchi, Ken

    2009-01-01

    The main aim of my article is to describe how deeply Professor Husimi devoted himself to promote large accelerator projects in Japan, as the establishment of National Laboratory for High Energy Physics (KEK), Photon Factory and TRISTAN, in which I myself was deeply involved. In addition, some topics related that I was a student of Professor Husimi are also reported. (author)

  10. The Reluctant Professor: Implications for University Management

    Science.gov (United States)

    Schein, Edgar H.

    1973-01-01

    Stating the belief that most analyses of the university fail to deal realistically with the role of the professor, the author's purpose is to show why it is difficult and possible undesirable to involve professors deeply in issues of university government. (Author/JB)

  11. Representações sociais de professores do ensino fundamental sobre violência intrafamiliar

    Directory of Open Access Journals (Sweden)

    Sandra Francesca Conte de Almeida

    Full Text Available Este estudo focaliza as representações sociais de professores do ensino fundamental acerca da violência intrafamiliar. A amostra foi de 94 professores de escolas públicas e privadas (Distrito Federal e Goiás, graduandos em Pedagogia. Na coleta de dados, aplicou-se um questionário visando apreender as representações sobre violência intrafamiliar, nas dimensões informação, campo das representações sociais e atitudes dos sujeitos diante de casos comprovados ou suspeitos de alunos vitimados pela violência intrafamiliar. Os resultados apontam contradições e ambivalências entre os sentimentos e as atitudes dos professores em relação ao fenômeno. Indicam, ainda, que a representação social da violência intrafamiliar, para grande parte dos sujeitos, ainda passa pela consideração do poder da autoridade paterna/familiar, que dá direito aos pais de educar seus filhos como melhor lhes convier, indicando a necessidade da capacitação de professores, no âmbito da formação inicial e continuada, para lidar adequadamente com a problemática da violência intrafamiliar, no cotidiano escolar.

  12. Pós-modernidade e novas tecnologias no discurso do professor de língua

    Directory of Open Access Journals (Sweden)

    Maria José R. Faria Coracini

    2006-01-01

    Full Text Available

    Este texto pretende apresentar algumas reflexões em torno da identidade do professor, atravessada pelo discurso da pós modernidade na vertente que se apóia nas novas tecnologias como resultado do chamado progresso científico. Para este estudo, baseamo-nos nas teorias do discurso, na psicanálise e na filosofia derrideana, cuja tarefa é desconstruir o edifício logocêntrico da cultura ocidental. Depois de analisar 50 redações de professores, foi possível observar que coabitam crenças que remetem ao professor missionário e idealista e a mitificação das novas tecnologias como a solução para os problemas de método e de motivação. Chocam-se, assim, resistências ao passado e resistências às novas tecnologias, que perturbam a garantia do saber e, portanto, do poder do professor, enfatizando o saber do aluno. O desejo da tranqüilidade e do conforto da verdade e da totalidade, garantido pela Torre de Marfim, se fragiliza na insegurança e nas incertezas da Torre de Babel (reconstruída pela (pós-modernidade, em que vigoram a complexidade, a heterogeneidade e a impossibilidade de completude.

  13. Fatores que tornam o professor de Ensino Superior bem-sucedido: analisando um caso

    Directory of Open Access Journals (Sweden)

    Ana Luiza de Quadros

    2014-03-01

    Full Text Available Este trabalho faz parte de uma investigação sobre as práticas pedagógicas bem-sucedidas usadas por professores universitários. Com o objetivo de investigar as estratégias usadas por um professor bem avaliado pelos estudantes, registramos, em vídeo, um conjunto de aulas e fizemos a análise das mesmas. Esta análise permitiu um entendimento inicial de como o professor organiza o seu próprio trabalho, como navega entre diferentes tipos de discursos e como dá suporte ao processo de significação. Ao mesmo tempo, a análise revelou como as interações são produzidas no espaço/tempo da sala de aula, e como as diferentes estratégias usadas auxiliam no engajamento dos estudantes. Por meio de entrevista semiestruturada, buscamos, no professor, indícios que nos permitissem entender como este construiu as estratégias usadas nas aulas. Observamos a presença de um processo reflexivo sobre as experiências vividas e identificamos algumas pistas que nos permitiram argumentar sobre a construção dessas estratégias.

  14. Processo Ensino‐Aprendizagem: Características do Professor Eficaz

    Directory of Open Access Journals (Sweden)

    C. Albuquerque

    2016-02-01

    Uma análise global sobre o conjunto dos indicadores que, na opinião dos alunos, incorporam cada dimensão associada ao professor eficaz, permite identificar a preocupação e o reconhecimento da importância do “conviver”, do “conhecer”, e “do saber comunicar” como “os três pilares” em que assenta a qualidade do ensino/educação.

  15. Remembering for tomorrow: Professor Mansour Ali Haseeb.

    Science.gov (United States)

    Salih, Mustafa Abdalla M

    2013-01-01

    This is a highlight of the obituary ceremony in tribute to Professor Mansour Ali Haseeb (1910 - 1973), organized by the Medical Students Association of the Faculty of Medicine, the University of Khartoum (U of K). Professor Haseeb has been the first Sudanese Professor and first Dean of the Faculty of Medicine. He was an outstanding humane teacher, mentor and researcher, and was awarded the international Dr. Shousha Foundation Prize and Medal by the WHO. He was also an active citizen in public life and became Mayor of Omdurman City. The obituary ceremony reflected the feelings of the medical community and included speeches by Professor Abdalla El Tayeb, President of U of K; the Dean, Faculty of Medicine; the Late Professor Haseeb's colleagues and students, His family representative, and an elegy poem.

  16. aliving with Huntington´s disease in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Baxa, Monika

    2015-01-01

    Roč. 78, Suppl 2 (2015), s. 6-6 ISSN 1210-7859. [Conference on Animal Models for neurodegenerative Diseases /3./. 08.11.2015-10.11.2015, Liblice] Institutional support: RVO:67985904 Keywords : Czech Huntington Association * life with Huntington ´ disease Subject RIV: FH - Neurology

  17. 77 FR 71636 - Huntington Foam LLC, Fort Smith, AR; Notice of Revised Determination on Reconsideration

    Science.gov (United States)

    2012-12-03

    ... Smith, AR; Notice of Revised Determination on Reconsideration On August 8, 2012, the Department of Labor... workers and former workers of Huntington Foam LLC, Fort Smith, Arkansas (subject firm). The workers are... reconsideration investigation, I determine that workers of Huntington Foam LLC, Fort Smith, Arkansas, who were...

  18. Did the "Woman in the Attic" in Jane Eyre Have Huntington Disease?

    Science.gov (United States)

    Coon, Elizabeth A; Hassan, Anhar

    2015-01-01

    References to neurologic disorders are frequently found in fictional literature and may precede description in the medical literature. Our aim was to compare Charlotte Brontë's depiction of Bertha Mason in Jane Eyre to the tenets set forth in George Huntington's original essay "On chorea" with the hypothesis that Mason was displaying features of Huntington disease. Charlotte Brontë's 1847 Victorian novel Jane Eyre features the character Bertha Mason, who is portrayed with a progressive psychiatric illness, violent movements, and possible cognitive decline. Similar to Huntington's tenets, Mason has a disorder with a strong family history suggestive of autosomal dominant inheritance with onset in adulthood, and culminating in suicide. Brontë's character had features of Huntington disease as originally described by Huntington. Brontë's keen characterization may have increased awareness of treatment of neuropsychiatric patients in the Victorian era.

  19. Internal consistency of a Brazilian version of the unified Huntington's disease rating scale Consistência interna da versão brasileira da escala unificada para avaliação da doença da Huntington

    Directory of Open Access Journals (Sweden)

    Vitor Tumas

    2004-12-01

    ídeo divulgado para esse objetivo e um manual solicitado aos idealizadores da escala, nós aplicamos a UHDRS, com exceção dos testes cognitivos, em um grupo de 21 pacientes brasileiros com diagnóstico molecular de doença de Huntington (DH. Nessa amostra nós encontramos uma elevada consistência interna na seção que avalia os sintomas motores (alfa de Cronbach= 0,841. Observamos uma correlação negativa entre o escore total da escala motora e as escalas de avaliação funcional, de independência e de capacidade funcional total; uma correlação positiva entre essas 3 últimas escalas; e uma correlação negativa entre a idade de início dos sintomas e o número de repetições CAG. As características clínicas dessa amostra de pacientes descritas segundo a UHDRS é de maneira comparativa similar às descritas nos estudos originais de validação da escala, assim como as correlações descritas são semelhantes às descritas previamente. Concluimos que a versão brasileira da UHDRS é confiável e válida para estudar pacientes com DH aqui no Brasil, que essa amostra, como era esperado, tem características semelhantes às descritas em outras regiões do mundo, e que o m��todo utilizado para treinamento da aplicação da escala é válido.

  20. Sensibilizar professores para o desenvolvimento de carreira dos alunos: relato de uma experiência

    Directory of Open Access Journals (Sweden)

    Íris M. Oliveira

    Full Text Available A literatura destaca a importância de realizar sessões de sensibilização dos professores para promover a sua influência positiva e intencional, enquanto docentes, nas trajetórias de carreira dos alunos. Este artigo relata uma experiência de realização de uma sessão de sensibilização junto a professores da educação básica de um agrupamento de escolas no noroeste de Portugal. Procurou-se esclarecer o conceito de desenvolvimento de carreira junto dos professores, conscientizá-los para o papel da escola no desenvolvimento de carreira dos alunos e estimular a dinamização de atividades promotoras desse processo. Apresenta-se a estrutura da sessão, as estratégias adotadas para alcançar os objetivos propostos e as reflexões partilhadas e debatidas pelos professores. As apreciações dos intervenientes quanto à sessão de sensibilização mostraram-se favoráveis. Esta experiência ilustra a importância de realizar sessões de sensibilização dos professores nesse domínio, as quais podem sustentar a promoção do desenvolvimento de carreira dos alunos, ao longo da escolaridade.

  1. O ensino e a experiência nas narrativas de professores de Inglês

    Directory of Open Access Journals (Sweden)

    Annallena de Souza Guedes

    2016-09-01

    Full Text Available Resumo: Este trabalho tem como objetivo analisar três narrativas de professores de Inglês em exercício, através das quais são reveladas experiências que dizem respeito ao processo de ensinar Inglês em contextos de instituições públicas no Brasil. Pautado no conceito de experiência (MICCOLI, 2010, buscamos compreender quais experiências emergem dessas narrativas e como elas influenciam na prática de ensino dos professores. Ademais, intentamos analisar como os professores de Inglês se veem e quais desafios ele enfrentam nos seus contextos de trabalho. Os resultados desse estudo mostraram que, apesar de todas as experiências de dificuldades e indisciplina reveladas nas narrativas, duas delas parecem ainda encontrar motivação e esperança quanto à sua profissão. Além disso, percebemos que o modo como os professores veem sua realidade, seus alunos e seu trabalho são importantes para caracterizar sua prática profissional. Assim, acreditamos que o contexto e as experiências retratados nas narrativas podem ser caminhos que direcionem as ações desses professores em sala de aula e, consequentemente, possibilitem reflexões e mudanças no seu papel como educador. 

  2. Modos de ser enfermeiro-professor-no-ensino-do-cuidadode-enfermagem: um olhar heideggeriano

    Directory of Open Access Journals (Sweden)

    Luciara Fabiane Sebold

    2013-08-01

    Full Text Available Estudo qualitativo de abordagem fenomenológica. Objetivou desvelar, à luz do pensamento de Martin Heidegger, os modos de ser dos enfermeiros-professores na vivência de ensinar-aprender o cuidado de enfermagem em uma instituição federal de ensino superior do sul do Brasil. A técnica utilizada para captar os significados foi a entrevista fenomenológica com 11 docentes. A análise permitiu compreender os Modos de Ser enfermeiro-professor, que foram didaticamente apresentados em duas unidades de significado: Modo de ser enfermeiro para o cuidado; Modo de ser professor para o ensino do cuidado. Alguns professores identificam-se como enfermeiros, suas experiências profissionais são suas bases e a coexistência com outros pôde lhes servir de exemplo. Outros se percebem professores de enfermagem e desejam ensinar os desafios de ser enfermeiro, e aprimoram o cuidado através de pesquisas. Ao ensinar, envolvem-se com o universo de ensino no qual o cuidar também é aprender e ensinar.

  3. Estilos motivacionais de professores: preferência por controle ou por autonomia

    Directory of Open Access Journals (Sweden)

    Amélia Carolina Terra Alves Machado

    Full Text Available A motivação é fundamental para o envolvimento dos estudantes na escola. Para a teoria da autodeterminação, o estilo motivacional do professor, que pode controlar ou promover a autonomia, contribui para fomentar a ocorrência de tipos qualitativamente diferenciados de motivação. Neste estudo, de natureza exploratória, foram analisadas as interações entre dois professores e seus alunos. A amostra foi composta de acordo com o desempenho de 39 professores na avaliação do estilo motivacional, mediante a aplicação de um instrumento de autorrelato, problemas na escola. Desse total, dois professores, um com estilo motivacional promotor de autonomia e outro com uma orientação para o controle, tiveram suas aulas observadas em sete sessões, com o objetivo de levantar dados para a elaboração de um protocolo que continha categorias de interações. Foram então realizadas outras sete sessões de observação. Os resultados indicaram que, apesar de terem sido encontradas diferenças entre os desempenhos na avaliação do estilo motivacional, os professores interagiram com seus alunos de modo preferencialmente controlador. No entanto, o professor que promovia a autonomia interagiu de modo menos controlador no gerenciamento do tempo destinado para a realização das atividades em classe quando comparado ao professor controlador, além de oferecer feedback informativo. As implicações educacionais dos resultados são analisadas.

  4. In Conversation with: Professor Liz Thomas

    Directory of Open Access Journals (Sweden)

    Karen Nelson

    2012-08-01

    Full Text Available Editors Karen Nelson, John Clarke and Sally Kift interview Professor Liz Thomas,  Director of the Widening Participation Research Centre at Edge Hill University.  She is also Lead Adviser Retention and Success at the Higher Education Academy, England.   Professor Thomas was one of the keynote speakers at the 15th International First Year in Higher Education Conference held in Brisbane, Australia from the 26th – 29th of June, 2012.  Professor Thomas joined the Journal Editors at the conclusion of the main conference program to explore some of the key themes raised in her address.  

  5. Radiosensitivity in Huntington's disease: implications for pathogenesis and presymptomatic diagnosis

    International Nuclear Information System (INIS)

    Moshell, A.N.; Tarone, R.E.; Barrett, S.F.; Robbins, J.H.

    1980-01-01

    Huntington's disease (HD) is a dominantly inherited fatal disorder characterised by premature death of nerve cells. Cultured lymphocyte lines from four patients with HD were abnormally sensitive to the lethal effects of X rays, as were lines from two of five subjects at risk for HD. The hypersensitivity is specific for ionising radiation, since HD lines had normal survival after exposure to ultraviolet radiation. The hypersensitivity, which may reflect an inherited defect in DNA repair, provides the basis for a presymptomatic diagnostic test for the disease. (author)

  6. Prevalência de queixas vocais e estudo de fatores associados em uma amostra de professores de ensino fundamental em Maceió, Alagoas, Brasil

    OpenAIRE

    Alves, Luciano Padilha; Araújo, Laura Tathianne Ramos; Xavier Neto, José Augusto

    2010-01-01

    INTRODUÇÃO: A voz é o principal instrumento na vida profissional do professor, requerendo uma adaptação precisa dos órgãos da fonação. O desconhecimento da disfonia em professores de nossa região motivou esta pesquisa. OBJETIVOS: Avaliar a frequência de disfonia em professores do Ensino Fundamental da rede municipal em Maceió-AL e identificar sintomas associados às queixas vocais e possíveis fatores de risco ao aparecimento de alterações vocais. METODOLOGIA: Estudo transversal abrangendo 126 ...

  7. Turning university professors into competent learners

    NARCIS (Netherlands)

    Stefanova, Eliza; Ilieva, Miroslava; Nikolova, Nikolina; Stefanov, Krassen

    2008-01-01

    Stefanova, E., Ilieva, M., Nikolova, N, & Stefanov, K. (2008). Turning university professors into competent learners. In H. W. Sligte & R. Koper (Eds.), Proceedings of the 4th TENCompetence Open Workshop. Empowering Learners for Lifelong Competence Development: pedagogical, organisational and

  8. Lifelong learning: Science professors need leadership training

    OpenAIRE

    Leiserson, Charles E.; McVinney, Chuck

    2015-01-01

    Education does not stop. Professors must update and develop their technical skills throughout their careers. But as they progress, few take the time — or are offered the opportunity — to become educated in how to be an effective leader.

  9. Estresse e enfrentamento em professores: uma análise da literatura

    Directory of Open Access Journals (Sweden)

    Kelly Ambrosio Silveira

    2014-12-01

    Full Text Available O estresse tem sido associado a problemas de saúde em professores, sendo importante compreender suas estratégias de enfrentamento (coping. Assim, o presente estudo revisou a literatura sobre estresse e coping em professores, com a análise dos principais resultados de pesquisas da área e de suas características metodológicas. Foram analisados artigos publicados entre 2006-2011 em bases internacionais do Portal Periódicos/CAPES, com as palavras-chave: stress, coping e teacher. Os 19 artigos sobre o tema disponíveis integralmente foram analisados. A partir desse material, procedeu-se análise relacionada ao estresse, às estratégias de enfrentamento e às suas implicações para o trabalho docente. É evidenciada a necessidade de práticas avaliativas e interventivas em atenção ao coping e aos sintomas de estresse, de modo a ampliar a compreensão sobre os processos que levem ao bem-estar docente e, consequentemente, à qualidade do ensino ofertado.

  10. Professor dr hab. Anna Maria Bujakiewicz

    Directory of Open Access Journals (Sweden)

    Anna Kujawa

    2015-08-01

    Full Text Available The article presents the biography and scientific achievements of Professor Anna Bujakiewicz. After receiving her master’s degree and doctorate in biology and mycology from Adam Mickiewicz University in Poznań, Professor Bujakiewicz continued her exciting research and teaching on mycology at her Alma Mater Posnaniensis for more than 50 years. Her publications in this field include many books, articles, and other scholarly reports.

  11. Inter-relação entre professores da sala de atendimento educacional especializado e do ensino regular

    Directory of Open Access Journals (Sweden)

    Valéria de Oliveira

    2017-11-01

    Full Text Available O presente estudo teve por objetivo principal: mapear e analisar o nível e a forma de articulação entre os professores e as atividades desenvolvidas em Salas de Recursos Multifuncionais (SRMs e salas comuns, em uma proposta inclusiva. Com o intuito de contribuir para o processo da educação inclusiva no ambiente escolar, estabeleceu-se aqui a abordagem quanti-qualitativa do tipo transversal. Utilizou-se um questionário para os professores de sala comum e professores de SRM. Participaram deste estudo dezesseis professores de sala comum que tinham alunos com deficiência e nove de SRM da rede pública de ensino de dois municípios da Região Metropolitana de Campinas. Para a análise de conteúdo dos questionários, tomou-se como referência a obra de Bardin, que aponta três fases fundamentais no processo: pré-análise, exploração do material e tratamento dos resultados. Por meio deste estudo, foi possível concluir que: (a os professores estão cientes da importância da SRM e das atribuições dos professores que atuam nesse espaço - todavia, não parece estar claro o trabalho do professor da sala comum -, (b há uma inter-relação entre professores de sala comum e SEM - todavia falta maior tempo destinado às trocas necessárias -, e (c em alguns casos, há falta de entendimento do professor de sala comum sobre a sua função quanto ao aluno Público-Alvo da Educação Especial (PAEE.

  12. Sintomas vocais e perfil de professores em um programa de saúde vocal Vocal symptoms and profile of teachers in a vocal health program

    OpenAIRE

    Karin Choi-Cardim; Mara Behlau; Fabiana Zambon

    2010-01-01

    OBJETIVO: analisar sintomas vocais de dois grupos de professores que foram avaliados em momentos distintos de um programa de saúde vocal. MÉTODOS: correlacionar condições de trabalho e hábitos com o número de sintomas vocais apresentados por 411 professores, agrupados em G1 (256 sujeitos a serem submetidos ao programa preventivo) e G2 (155 sujeitos a serem submetidos ao programa preventivo e de tratamento). RESULTADOS: em ambos os grupos observou-se predomínio de mulheres (p = 0,550), entre 3...

  13. Motor outcome measures in Huntington disease clinical trials.

    Science.gov (United States)

    Reilmann, Ralf; Schubert, Robin

    2017-01-01

    Deficits in motor function are a hallmark of Huntington disease (HD). The Unified Huntington's Disease Rating Scale Total Motor Score (UHDRS-TMS) is a categoric clinical rating scale assessing multiple domains of motor disability in HD. The UHDRS-TMS or subsets of its items have served as primary or secondary endpoints in numerous clinical trials. In spite of a well-established video-based annual online certification system, intra- and interrater variability, subjective error, and rater-induced placebo effects remain a concern. In addition, the UHDRS-TMS was designed to primarily assess motor symptoms in manifest HD. Recently, advancement of technology resulted in the introduction of the objective Q-Motor (i.e., Quantitative-Motor) assessments in biomarker studies and clinical trials in HD. Q-Motor measures detected motor signs in blinded cross-sectional and longitudinal analyses of manifest, prodromal, and premanifest HD cohorts up to two decades before clinical diagnosis. In a multicenter clinical trial in HD, Q-Motor measures were more sensitive than the UHDRS-TMS and exhibited no placebo effects. Thus, Q-Motor measures are currently explored in several multicenter trials targeting both symptomatic and disease-modifying mechanisms. They may supplement the UHDRS-TMS, increase the sensitivity and reliability in proof-of-concept studies, and open the door for phenotype assessments in clinical trials in prodromal and premanifest HD. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Huntington's Disease in a Patient Misdiagnosed as Conversion Disorder.

    Science.gov (United States)

    Nogueira, João Machado; Franco, Ana Margarida; Mendes, Susana; Valadas, Anabela; Semedo, Cristina; Jesus, Gustavo

    2018-01-01

    Huntington's disease (HD) is an inherited, progressive, and neurodegenerative neuropsychiatric disorder caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide in Interested Transcript (IT) 15 gene on chromosome 4. This pathology typically presents in individuals aged between 30 and 50 years and the age of onset is inversely correlated with the length of the CAG repeat expansion. It is characterized by chorea, cognitive deficits, and psychiatric symptoms. Usually the psychiatric disorders precede motor and cognitive impairment, Major Depressive Disorder and anxiety disorders being the most common presentations. We present a clinical case of a 65-year-old woman admitted to our Psychiatric Acute Unit. During the 6 years preceding the admission, the patient had clinical assessments made several times by different specialties that focused only on isolated symptoms, disregarding the syndrome as a whole. In the course of her last admission, the patient was referred to our Neuropsychiatric Team, which made the provisional diagnosis of late-onset Huntington's disease, later confirmed by genetic testing. This clinical vignette highlights the importance of a multidisciplinary approach to atypical clinical presentations and raises awareness for the relevance of investigating carefully motor symptoms in psychiatric patients.

  15. Apolipoprotein E and presenilin-1 genotypes in Huntington's disease.

    Science.gov (United States)

    Panas, M; Avramopoulos, D; Karadima, G; Petersen, M B; Vassilopoulos, D

    1999-07-01

    Huntington's disease (HD) is an autosomal dominant degenerative disease of the central nervous system manifested by involuntary movements (chorea), psychiatric manifestations, and cognitive impairment with a variable age at onset. This variability is mainly attributed to genetic factors. The so-called aging genes [e.g., those for apolipoprotein E (APOE) and presenilin-1 (PS-1) have been implicated in determining the age at onset of Alzheimer's disease, a disease sharing common clinical features with HD. In 60 unrelated patients suffering from HD (mean age at onset 40.1 years, range 20-65) we determined number of CAG repeats and the distribution of the APOE alleles (epsilon2, epsilon3, epsilon4) and PS-1 alleles. The results showed that: (a) The age at onset was higher in the group of patients with the epsilon4 allele (51.6 vs. 38.0 P<0.002), (b) The correlation between the age at onset and the number of CAG repeats was strong in patients with the epsilon3/epsilon3 genotype while it was not detected in patients with epsilon3/epsilon4 genotype. (c) No correlation was found between age at onset and PS-1 alleles. In conclusion, APOE seems to be a significant factor influencing the age at onset of Huntington's disease.

  16. Carta ao Leitor

    Directory of Open Access Journals (Sweden)

    Editorial Editorial

    2014-02-01

    Full Text Available ApresentaçãoO Centro de Educação a Distância – CEAD/Unimontes foi inaugurado em 2011 em histórico de ricas experiências vivenciadas pela Universidade Estadual de Montes Claros – Unimontes ao longo de 15 anos.Uma jornada de esforços conjuntos e uma estima apaixonada pela educação e pelo conheci-mento científico carecia, em seu núcleo, de uma plataforma que reunisse todas as perspectivas constitutivas de sua história e finalidade. Um anseio crescente da instituição que se desdobra e desdobrará em produtos e iniciativas de fomento em pesquisa. Em 2012, como fruto gerado di-retamente do âmago dessas necessidades unidas ao cenário nacional de valorização crescente da pesquisa científica, surge a Revista Multitexto.A Revista Multitexto nasce como um periódico em movimento. São contribuições de aborda-gens múltiplas num ensejo genuíno e único de progressão científica em pesquisa. Um marco para os estudos na área de ensino a distância numa oferta interdisciplinar. Unidade na diversidade: a grande proposta da revista. Espaço aberto para pesquisadores e entusiastas. Multipliquem-se os multitextos em contribuições múltiplas.Sobre a Revista MultitextoPublicação semestral do Centro de Educação a Distância da Universidade Estadual de Montes Claros – CEAD/Unimontes, que contribui na área de conhecimento produzida pelas fenomenologias e áreas correlatas em Educação a Distância, com foco interdisciplinar. Aberta em 2012, a Revista Multitexto recebe colaborações de pesquisadores em ensino a dis-tância e demais áreas. É meta referencial da revista abordar questões conceituais e metodológicas, bem como, os desenvolvimentos da pesquisa, aplicada ou teórica, na área de educação à distância (EAD; difundir a produção científica de pesquisadores da área de educação à distância (EAD, inseridos em Institutos de pesquisa e de educação superior no Brasil; propiciar um espaço para o

  17. Xeroderma pigmentosum is a definite cause of Huntington's disease-like syndrome.

    Science.gov (United States)

    Garcia-Moreno, Hector; Fassihi, Hiva; Sarkany, Robert P E; Phukan, Julie; Warner, Thomas; Lehmann, Alan R; Giunti, Paola

    2018-01-01

    Xeroderma pigmentosum is characterized by cutaneous, ophthalmological, and neurological features. Although it is typical of childhood, late presentations can mimic different neurodegenerative conditions. We report two families presenting as Huntington's disease-like syndromes. The first case (group G) presented with neuropsychiatric features, cognitive decline and chorea. Typical lentigines were only noticed after the neurological disease started. The second case (group B) presented adult-onset chorea and neuropsychiatric symptoms after an aggressive ocular melanoma. Xeroderma pigmentosum can manifest as a Huntington's Disease-like syndrome. Classic dermatological and oncological features have to be investigated in choreic patients with negative genetic tests for Huntington's disease-like phenotypes.

  18. Formador de leitores, formador de professores: a trajetória de Max Butlen

    Directory of Open Access Journals (Sweden)

    Belmira Oliveira Bueno

    2015-06-01

    Full Text Available Nesta entrevista, Max Butlen, amplamente conhecido por seu trabalho no campo da leitura, da formação de leitores e de professores, traça um percurso de sua trajetória e desenvolve uma discussão rica a partir das contribuições teóricas assentadas em uma longa vivência na escola pública, que o tornaram referência em dois temas dentre os mais desafiadores para a escola nos dias de hoje: o ensino da cultura da escrita e a profissionalização dos professores. Na França, foi sucessivamente professor em diferentes instituições de formação de professores, junto ao Ministério da Educação e o da Cultura, onde, em funções e cargos múltiplos, fez sobressair seu trabalho em prol da atualização das práticas escolares de leitura e da configuração e uso das bibliotecas públicas e escolares. Sua tese de doutorado em ciências da educação, Les politiques de lecture et leurs acteurs, 1980-2000, defendida na Universidade de Paris 5, reúne esses dois campos de saberes universitários e da ação profissional e mostra a centralidade que as questões da leitura assumem na França nos finais do século XX. No Brasil, ele trabalhou junto ao Ministério da Educação, de 1994 a 1998, ampliando, desde então, sua colaboração com grupos de pesquisadores de vários estados, para tratar seja das temáticas da leitura seja daquelas referidas à universitarização dos professores. Desenvolve também, a partir de suas experiências em ambos os países, comparações profícuas no que se refere a procedimentos de formação de professores e ao comportamento intelectual dos jovens diante das novas tecnologias e das mudanças sociais.

  19. Accounting Professor Qualification in Digital Age: A Perception Study on Brazilian Professors

    Science.gov (United States)

    Vendruscolo, Maria Ivanice; Behar, Patrícia Alejandra

    2015-01-01

    This papers aims at analyzing the perception of Accounting professors about the necessary qualifications in Accounting undergraduate courses. The contribution of this study is to theoretically discuss the education of Accounting professors, with empirical data, because Accounting teaching requires specific competencies in the digital area. The…

  20. Satisfaction among accounting professors in Brazil

    Directory of Open Access Journals (Sweden)

    Tamires Sousa Araújo

    Full Text Available ABSTRACT The aim of this study was to identify the prevalence of satisfaction among accounting professors in Brazil throughout their careers. The research is classified as descriptive and used a quantitative approach to data analysis. 641 valid responses were obtained from professors from all regions of Brazil. The results show that a feeling of satisfaction prevails among accounting course professors, as most of them “like the profession” and, in general, "are satisfied with it”. It was found that levels of satisfaction are higher among individuals with more experience, in that in their first years in the job (one to three years, professors have lower satisfaction rates; the highest levels of satisfaction are found in the final stage (over 35 years. The main factor that influences satisfaction is personal fulfillment (teaching work and relationship with students. It was also possible to identify that positive feelings about teaching predominate (67.3% compared to negative ones (32.7%. These results show the need for greater attention to be paid in the early years of the career in order to avoid a "reality clash". They also show the need for other studies to investigate how the phases in the life cycle of accounting professors are characterized.

  1. Dr. Rudolph Binion: professor, mentor, psychohistorian.

    Science.gov (United States)

    Szaluta, Jacques

    2015-01-01

    As the title of my paper indicates, Dr. Rudolph Binion was my professor, mentor, and a leading psychohistorian. My paper in memoriam to Rudolph Binion is intended as both a retrospective and an introspective account of my relationship with him, as he had a pivotal influence on me when he was my professor at Columbia University. His help and influence continued after I left graduate school. In my paper I also deal with the enormous stresses of navigating through graduate school, for those students whose goal was to earn the Ph.D. degree. Some examinations were dreaded, For Example The "Examination in Subjects," popularly called the "Oral Exam." The "incubation" period was long indeed, frequently averaging nearly ten years, and it was an ordeal, as the rate of attrition was very high. There is then also the question of "ego strength" and that of "transference" toward the professor. Graduate school is indeed a long and strenuous challenge. I took a seminar in modern French history, a requirement for the Master's degree with Professor Binion, which was consequential for me, as he taught me to be objective in writing history. Professor Binion was a demanding and outstanding teacher.

  2. The housekeeper and the professor a novel

    CERN Document Server

    Ogawa, Yoko

    2010-01-01

    He is a brilliant math Professor with a peculiar problem—ever since a traumatic head injury, he has lived with only eighty minutes of short-term memory. She is an astute young Housekeeper—with a ten-year-old son—who is hired to care for the Professor. And every morning, as the Professor and the Housekeeper are introduced to each other anew, a strange and beautiful relationship blossoms between them. Though he cannot hold memories for long (his brain is like a tape that begins to erase itself every eighty minutes), the Professor's mind is still alive with elegant equations from the past. And the numbers, in all of their articulate order, reveal a sheltering and poetic world to both the Housekeeper and her young son. The Professor is capable of discovering connections between the simplest of quantities—like the Housekeeper's shoe size—and the universe at large, drawing their lives ever closer and more profoundly together, even as his memory slips away. Yoko Ogawa's The Housekeeper and the Professo...

  3. Barreiras à criatividade pessoal entre professores de distintos níveis de ensino

    Directory of Open Access Journals (Sweden)

    Alencar Eunice M.L. Soriano de

    2003-01-01

    Full Text Available Este estudo investigou distintas modalidades de barreiras à expressão da criatividade pessoal em uma amostra de 544 professores, que atuavam desde o ensino fundamental até o ensino superior. O Inventário de Barreiras à Criatividade Pessoal, construído e validado pela primeira autora, foi utilizado para coleta de dados. Este instrumento inclui itens relativos a quatro modalidades de barreiras: Inibição/Timidez, Falta de Tempo/Oportunidade, Repressão Social e Falta de Motivação. Diferenças significativas foram observadas entre professores do sexo masculino e feminino em Repressão Social, e, entre professores de diferentes níveis de ensino, nas barreiras denominadas Inibição/Timidez e Repressão Social. Os resultados apontam distintas barreiras que se referem direta ou indiretamente aos motivos, meios e oportunidades para a expressão da criatividade pessoal, sinalizando a necessidade de estratégias que ampliem as possibilidades de expressão criativa em professores.

  4. IDENTIFICANDO OS MODELOS DIDÁTICOS DE UM GRUPO DE PROFESSORES DE QUÍMICA

    Directory of Open Access Journals (Sweden)

    João Batista Santos Junior

    Full Text Available Esta investigação visa a identificar os modelos didáticos de um grupo de professores de Química de escolas públicas e propõe uma meto dologia para a sua utilização como instrumento de reflexão do docente em relação às suas concepções acerca do processo de ensino e aprendiza gem. Para tal, foi solicitado aos professores que respondessem a um ques tionário baseado nas ideias de Garcia Pérez (2000. Os resultados obtidos apontam que os professores combinam características diferentes dos modelos didáticos para formar um modelo didático eclético (GUIMARÃES, ECHEVERRÍA & MORAES, 2006. Esses modelos ecléticos encerram características antagônicas e podem indicar a necessi dade de aprofundamento da reflexão dos docentes sobre as suas concep ções. É proposta uma metodologia para a utilização do instrumento de investigação do pensamento do professor.

  5. Digital bedrock geologic map of parts of the Huntington, Richmond, Bolton and Waterbury quadrangles, Vermont

    Data.gov (United States)

    Vermont Center for Geographic Information — Digital Data from VG95-9A Thompson, PJ�and Thompson, TB, 1995, Digital bedrock geologic map of parts of the Huntington, Richmond, Bolton and Waterbury quadrangles,...

  6. The role of tau in the pathological process and clinical expression of Huntington's disease

    DEFF Research Database (Denmark)

    Vuono, Romina; Winder-Rhodes, Sophie; de Silva, Rohan

    2015-01-01

    and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clinical features, especially the dementia, are not fully understood. Recently the microtubule associated protein tau, MAPT, which is associated with several neurodegenerative disorders, has been implicated......-mortem brain samples from patients with Huntington's disease (n = 16) compared to cases with a known tauopathy and healthy controls. Next, we undertook a genotype-phenotype analysis of a large cohort of patients with Huntington's disease (n = 960) with a particular focus on cognitive decline. We report...... not only on the tau pathology in the Huntington's disease brain but also the association between genetic variation in tau gene and the clinical expression and progression of the disease. We found extensive pathological inclusions containing abnormally phosphorylated tau protein that co-localized in some...

  7. Huntington's disease does not appear to increase the risk of diabetes mellitus

    DEFF Research Database (Denmark)

    Boesgaard, T W; Nielsen, Troels Tolstrup; Josefsen, Knud Elnegaard

    2009-01-01

    Huntington's disease (HD) is an autosomal, dominantly inherited, neurodegenerative disorder characterised by neurological, cognitive and psychiatric symptoms. HD has been associated with diabetes mellitus, which is, to some extent, supported by studies in transgenic HD mice. In transgenic mice...

  8. Transgenic miniature pig as a model for the study of Huntington´s Disease

    Czech Academy of Sciences Publication Activity Database

    Baxa, Monika

    2012-01-01

    Roč. 22, č. 2 (2012), s. 23-25 ISSN 1210-1737 Institutional support: RVO:67985904 Keywords : transgenic pig * Huntington ´s disease * large animal model * neurodegenerative disease Subject RIV: EB - Genetics ; Molecular Biology

  9. Huntington Revisited: Is Conservative Realism Still Essential for the Military Ethic

    National Research Council Canada - National Science Library

    Mahoney-Norris, Kathleen A

    2001-01-01

    ...). Furthermore, Huntington has developed what appears to be a powerful argument as to why conservative realism should be considered a fundamental component of the professional ethic of the military officer...

  10. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

    OpenAIRE

    Hensman Moss, Davina J; Pardinas, Antonio; Langbehn, Douglas; Lo, Kitty; Leavitt, Blair R; Roos, Raymund; Durr, Alexandra; Mead, Simon; Holmans, Peter; Jones, Lesley; Tabrizi, Sarah J; Coleman, A; Santos, R Dar; Decolongon, J; Sturrock, A

    2017-01-01

    Background\\ud \\ud Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure.\\ud \\ud Methods\\ud \\ud We generated a progression score on the basis of principal ...

  11. Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's disease

    DEFF Research Database (Denmark)

    Petersen, Maria Hvidberg; Budtz-Jørgensen, Esben; Sørensen, Sven Asger

    2014-01-01

    Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by movement disorder, cognitive symptoms and psychiatric symptoms with predominantly adult-onset. The mutant huntingtin protein leads to mitochondrial dysfunction in blood leukocytes. This discovery led to the inve......Huntington's disease (HD) is an inherited neurodegenerative disorder characterised by movement disorder, cognitive symptoms and psychiatric symptoms with predominantly adult-onset. The mutant huntingtin protein leads to mitochondrial dysfunction in blood leukocytes. This discovery led...

  12. [The life as a caregiver of a person affected by Chorea Huntington: multiple case study].

    Science.gov (United States)

    Winkler, Evi; Ausserhofer, Dietmar; Mantovan, Franco

    2012-10-01

    Chorea Huntington is an autosomal dominantly inherited, neurodegenerative brain disorder that leads to involuntary hyperkinesia, psychotic symptoms and dementia. The illness not only changes the life of the person itself but also the world of the caregivers. The challenges in the care of a person which is affected by Chorea Huntington have an effect on the daily living as an assemblage of natural and social conditions. a multiple case study was conducted. It included semi-structured interviews with three caregivers of people with Chorea Huntington in South Tyrol. The qualitative data was analyzed using the qualitative structured analysis of Mayring (2007). The objective of this study was to describe the phenomenon of change of life from family members that care people affected by Chorea Huntington in a specific cultural setting (South Tyrol, Italy). The caregivers reported that the diagnosis of Chorea Huntington leads to negative changes in "relationship and family". Particularly, frustration, aggression, impatience and apathy were perceived as stressful. At the same time they highlight the positive changes through home care. They report that the relationship became more intimate and integral and it was characterized by more cohesion. Family caregivers get valuable support from the home care service, however, they complain that there is no facility in South Tyrol, which is specialized to care people with Chorea Huntington. Therefore, the caregivers have to "give up a lot" and don't have any personal desires, dreams and expectations for the future. The caregivers have learned independently to deal with their changed life step by step, and to see also the positive effects of the caring role. The life of family caregivers of a person which is affected by Chorea Huntington is characterized by abandonment. A continuous and professional care would be important for the affected and his caregiver. A continuous and professional care is important for both, addressing the

  13. Sodium phenylbutyrate in Huntington's disease: a dose-finding study.

    Science.gov (United States)

    Hogarth, Penelope; Lovrecic, Luca; Krainc, Dimitri

    2007-10-15

    Transcriptional dysregulation in Huntington's disease (HD) is mediated in part by aberrant patterns of histone acetylation. We performed a dose-finding study in human HD of sodium phenylbutyrate (SPB), a histone deacetylase inhibitor that ameliorates the HD phenotype in animal models. We used a dose-escalation/de-escalation design, using prespecified toxicity criteria and standard clinical and laboratory safety measures. The maximum tolerated dose was 15 g/day. At higher doses, toxicity included vomiting, lightheadedness, confusion, and gait instability. We saw no significant laboratory or electrocardiographic abnormalities. Gene expression changes in blood suggested an inverse dose-response. In conclusion, SPB at 12 to 15 g/day appears to be safe and well-tolerated in human HD. 2007 Movement Disorder Society

  14. Making a measurable difference in advanced Huntington disease care.

    Science.gov (United States)

    Moskowitz, Carol Brown; Rao, Ashwini K

    2017-01-01

    Neurologists' role in the care of people with advanced Huntington disease (HD) (total functional capacity speech and language pathology), behavioral and psychiatric professionals for problem-solving strategies, which must be reviewed with direct care staff before implementation; (3) encourage and support qualitative and quantitative interdisciplinary research studies, and randomized controlled studies of nonpharmacologic interventions; and (4) assist in the development of meaningful measures to further document what works to provide a good quality of life for the patient and family and a comfortable thoughtful approach to a good death. Collaborative models of care depend on: (1) clear communication; (2) ongoing education and support programs; with (3) pharmacologic and rehabilitation interventions, always in the context of respect for the person with HD, a preservation of the individuals' dignity, autonomy, and individual preferences. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Swallowing endoscopy findings in Huntington's disease: a case report.

    Science.gov (United States)

    Alves, Thaís Coelho; Cola, Paula Cristina; Santos, Rarissa Rúbia Dallaqua Dos; Motonaga, Suely Mayumi; Silva, Roberta Gonçalves da

    2016-01-01

    Huntington's disease (HD) is a degenerative genetic disorder with autosomal-dominant transmission. The triad of symptoms of this disease consists of psychiatric disorders, jerky movements, and dementia. Oropharyngeal dysphagia, which is more evident with disease progression, is also present. Few studies have addressed the swallowing characteristics using objective analysis in this population. The purpose of this research was to describe the swallowing endoscopic findings of the pharyngeal phase in HD. This is a cross-sectional study addressing a clinical case which included two individuals of the same family, male, 32 and 63 years old, designated as individual A and individual B, with progression of the disease for five and 13 years, respectively. Consistent liquid, nectar, and puree were offered during the evaluation. There was presence of posterior oral spillage in liquid and nectar, small amount of pharyngeal residues, and no laryngeal penetration or aspiration in the individuals with HD in this study.

  16. Structural imaging in premanifest and manifest Huntington disease.

    Science.gov (United States)

    Scahill, Rachael I; Andre, Ralph; Tabrizi, Sarah J; Aylward, Elizabeth H

    2017-01-01

    Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimaging provides a means to assess these effects in gene carriers. In this chapter we first outline the unique utility of structural imaging in understanding HD and discuss some of the acquisition and analysis techniques currently available. We review the existing literature to summarize what we know so far about structural brain changes across the spectrum of disease from premanifest through to manifest disease. We then consider how these neuroimaging findings relate to patient function and nonimaging biomarkers, and can be used to predict disease onset. Finally we review the utility of imaging measures for assessment of treatment efficacy in clinical trials. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. [Speed of ocular saccades in Huntington disease. Prospective study].

    Science.gov (United States)

    García Ruiz, P J; Cenjor, C; Ulmer, E; Hernández, J; Cantarero, S; Fanjul, S; García de Yébenes, J

    2001-02-01

    Oculomotor abnormalities, especially slow saccades, have long been recognized in Huntington's disease (HD). To study prospectively horizontal saccade velocity by videonystagmography in 21 patients with genetically confirmed HD. The study included a baseline analysis and a second evaluation after 18.8 +/- 7.1 months. We included a control group of 15 subjects. HD group exhibited decreased saccade velocity when compared with that from a control group (for predictive and unpredictive target). HD patients showed decreased saccade velocity with the passage of time (for predictive target, p < 0.01). Finally we found statistical significant correlation between saccade velocity and triplet length. The measurement of saccade velocity might be an objective method to study the natural evolution of HD, and thus evaluate the effectiveness of future therapies.

  18. Brain atrophy in Huntington's disease: A CT-scan study

    International Nuclear Information System (INIS)

    Starkstein, S.E.; Folstein, S.E.; Brandt, J.; McDonnell, A.; Folstein, M.

    1989-01-01

    CT-scan measurements of cortical and subcortical atrophy were carried out in 34 patients with Huntington's disease (HD). While a significant correlation was observed between parameters of subcortical atrophy (bicaudate ratio, bifrontal ratio and third ventricular ratio) and duration of the disease, there was no significant correlation between these parameters and age. On the other hand, measurements of cortical atrophy (frontal fissure ratio and cortical sulci ratio) correlated significantly with age but not with duration of the disease. When a group of 24 HD patients were compared on CT-scan measurements with a group of 24 age-matched normal controls, significant differences were obtained for all the variables examined, but the bicaudate ratio showed the highest sensitivity and specificity. Even mildly affected patients, with duration of motor symptoms less than 3 years had higher bicaudate ratios than age-matched controls. (orig.)

  19. Nucleic Acid-Based Therapy Approaches for Huntington's Disease

    Directory of Open Access Journals (Sweden)

    Tatyana Vagner

    2012-01-01

    Full Text Available Huntington's disease (HD is caused by a dominant mutation that results in an unstable expansion of a CAG repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with the disease. Since the mutation has multiple effects in the cell and the precise mechanism of the disease remains to be elucidated, gene therapy approaches have been developed that intervene in different aspects of the condition. These approaches include increasing expression of growth factors, decreasing levels of mutant huntingtin, and restoring cell metabolism and transcriptional balance. The aim of this paper is to outline the nucleic acid-based therapeutic strategies that have been tested to date.

  20. Reduced gluconeogenesis and lactate clearance in Huntington's disease

    DEFF Research Database (Denmark)

    Josefsen, Knud; Nielsen, Signe M B; Campos, André

    2010-01-01

    We studied systemic and brain glucose and lactate metabolism in Huntington's disease (HD) patients in response to ergometer cycling. Following termination of exercise, blood glucose increased abruptly in control subjects, but no peak was seen in any of the HD patients (2.0 ± 0.5 vs. 0.0 ± 0.2mM, P...... HD mouse model R6/2 following a lactate challenge, combined with reduced phosphoenolpyruvate carboxykinase and increased pyruvate kinase activity in the mouse liver suggest a reduced capacity...... for gluconeogenesis in HD, possibly contributing to the clinical symptoms of HD. We propose that blood glucose concentration in the recovery from exercise can be applied as a liver function test in HD patients....

  1. Perceptions of genetic discrimination among people at risk for Huntington's disease: a cross sectional survey.

    Science.gov (United States)

    Bombard, Yvonne; Veenstra, Gerry; Friedman, Jan M; Creighton, Susan; Currie, Lauren; Paulsen, Jane S; Bottorff, Joan L; Hayden, Michael R

    2009-06-09

    To assess the nature and prevalence of genetic discrimination experienced by people at risk for Huntington's disease who had undergone genetic testing or remained untested. Cross sectional, self reported survey. Seven genetics and movement disorders clinics servicing rural and urban communities in Canada. 233 genetically tested and untested asymptomatic people at risk for Huntington's disease (response rate 80%): 167 underwent testing (83 had the Huntington's disease mutation, 84 did not) and 66 chose not to be tested. Self reported experiences of genetic discrimination and related psychological distress based on family history or genetic test results. Discrimination was reported by 93 respondents (39.9%). Reported experiences occurred most often in insurance (29.2%), family (15.5%), and social (12.4%) settings. There were few reports of discrimination in employment (6.9%), health care (8.6%), or public sector settings (3.9%). Although respondents who were aware that they carried the Huntington's disease mutation reported the highest levels of discrimination, participation in genetic testing was not associated with increased levels of genetic discrimination. Family history of Huntington's disease, rather than the result of genetic testing, was the main reason given for experiences of genetic discrimination. Psychological distress was associated with genetic discrimination (PGenetic discrimination was commonly reported by people at risk for Huntington's disease and was a source of psychological distress. Family history, and not genetic testing, was the major reason for genetic discrimination.

  2. The Addenbrooke's Cognitive Examination-Revised accurately detects cognitive decline in Huntington's disease.

    Science.gov (United States)

    Begeti, Faye; Tan, Adrian Y K; Cummins, Gemma A; Collins, Lucy M; Guzman, Natalie Valle; Mason, Sarah L; Barker, Roger A

    2013-11-01

    Cognitive features, which begin before manifestation of the motor features, are an integral part of Huntington's disease and profoundly affect quality of life. A number of neuropsychological batteries have been used to assess this aspect of the condition, many of which are difficult to administer and time consuming, especially in advanced disease. We, therefore, investigated a simple and practical way to monitor cognition using the Addenbrooke's Cognitive Examination-Revised (ACE-R) in 126 manifest Huntington's disease patients, 28 premanifest gene carriers and 21 controls. Using this test, we demonstrated a selective decrease in phonemic, but not semantic, fluency in premanifest participants Cognitive decline in manifest Huntington's disease varied according to disease severity with extensive cognitive decline observed in early-stage Huntington's disease patients, indicating that this would be an optimal stage for interventions designed to halt cognitive decline, and lesser changes in the advanced cases. We next examined cognitive performance in patients prescribed antidopaminergic drugs as these drugs are known to decrease cognition when administered to healthy volunteers. We paradoxically found that these drugs may be beneficial, as early-stage Huntington's disease participants in receipt of them had improved attention and Mini-Mental State Examination scores. In conclusion, this is the first study to test the usefulness of the ACE-R in a Huntington's disease population and demonstrates that this is a brief, inexpensive and practical way to measure global cognitive performance in clinical practice with potential use in clinical trials.

  3. Illustrated & Dissected: Professor Richard Sawdon Smith.

    Science.gov (United States)

    2015-06-01

    This Alternative Gallery feature introduces the photographic artist Professor Richard Sawdon Smith. Professor Sawdon Smith's work stems around a fascination with representations of anatomy that have been fuelled by his experience as a hospital patient. The work has allowed him to explore ideas through the use of medical illustrations which include early anatomical drawings, personal medical photography and facial modelling. The work highlights how such imagery can be used in the context of a patient seeking understanding and acceptance of ill health and disease using the body as a canvas on which to translate the experience.

  4. Kai Adolf Jensen, professor i almindelig patologi

    DEFF Research Database (Denmark)

    Høiby, Niels

    2016-01-01

    for the Bacillus Calmette-Guérin vaccine production and supervised many young scientists’ doctoral theses on the aspects of tuberculosis. He became internationally recognized, and he revealed an important scientific fraud in the laboratory of the Austrian professor Ernst Löwenstein (1878-1950), who claimed that he...... could detect M. tuberculosis in blood cultures as a cause of a multitude of diseases. He was a pioneer in eradication of bovine tuberculosis in Denmark which became the first country in the world where this happened. Kai Adolf Jensen held the position as professor of general pathology from 1940 to 1965...

  5. Professor Stewart's casebook of mathematical mysteries

    CERN Document Server

    Stewart, Ian

    2014-01-01

    Like its wildly popular predecessors Cabinet of Mathematical Curiosities and Hoard of Mathematical Treasures, Professor Stewart's brand-new book is a miscellany of over 150 mathematical curios and conundrums, packed with trademark humour and numerous illustrations. In addition to the fascinating formulae and thrilling theorems familiar to Professor Stewart's fans, the Casebook follows the adventures of the not-so-great detective Hemlock Soames and his sidekick Dr John Watsup (immortalised in the phrase 'Watsup, Doc?'). By a remarkable coincidence they live at 222B Baker Street, just a

  6. Professor: Danmarkskanon skal give plads til mangfoldighed

    DEFF Research Database (Denmark)

    Schmidt, Garbi

    2016-01-01

    DEBAT: Danmark har igennem størstedelen af sin historie været et flerkulturelt land. Vi kan derfor ikke diskutere danske værdier til en Danmarkskanon uden at kaste et blik på globale strømninger og vores mangfoldige fortid, skriver Garbi Schmidt, professor ved RUC......DEBAT: Danmark har igennem størstedelen af sin historie været et flerkulturelt land. Vi kan derfor ikke diskutere danske værdier til en Danmarkskanon uden at kaste et blik på globale strømninger og vores mangfoldige fortid, skriver Garbi Schmidt, professor ved RUC...

  7. Orphan drugs in development for Huntington's disease: challenges and progress

    Directory of Open Access Journals (Sweden)

    Burgunder JM

    2015-02-01

    advanced strategies to develop novel treatments in Huntington's disease are examined. Keywords: Huntington's disease, symptomatic treatment, disease-modifying therapy

  8. (RE)PENSANDO A FORMAÇÃO DE PROFESSORES EM EDUCAÇÃO AMBIENTAL

    OpenAIRE

    Oliveira, Maria Aparecida Nunes de

    2015-01-01

    A formação de professores em Educação Ambiental numa perspectiva crítica é um dos instrumentos imprescindíveis para a efetivação da dimensão ambiental na escola. Foi realizada uma investigação tendo como base uma abordagem metodológica qualitativa, procurando analisar a formação dos professores em Educação Ambiental e como se dá a sua atuação na sala de aula no que se refere ao tratamento com as questões ambientais. A pesquisa teve como objetivo identificar as dificuldades enfrentadas por um ...

  9. Relação família e escola no contexto da inclusão: opinião de professores pré-escolares

    Directory of Open Access Journals (Sweden)

    Laura Borges

    2015-04-01

    Full Text Available O objetivo deste estudo foi o de descrever como os professores de crianças pré-escolares avaliam a relação entre a família e a escola, considerando especificamente o processo de inclusão. Participaram da pesquisa 20 professoras pré-escolares. Para responder aos objetivos, as professoras preencheram um questionário. Dentre os resultados têm-se que: (a 65% dos professores apontaram a socialização como o principal fator da escola que pode influenciar o sucesso da criança; (b 70% dos professores apontaram que a boa relação família e escola é tida por meio de troca de informações e diálogo; (c 85% dos professores apontaram as reuniões de pais e 65% o uso de bilhetes, como estratégias que utilizam para se comunicar com os pais e (d 45% dos professores relataram informar os pais sobre o desenvolvimento/aprendizagem da criança, como uma das principais ajudas que podem oferecer aos pais. Nota-se a necessidade de intervenção com pais e professores para estreitar a relação entre eles, a fim de que possam favorecer o desenvolvimento e a aprendizagem da criança pré-escolar incluída.

  10. Tornar-se negro: trajetÃrias de vida de professores universitÃrios no CearÃ

    OpenAIRE

    Maria Auxiliadora de Paula GonÃalves Holanda

    2009-01-01

    A pesquisa trata dos processos de construÃÃo de subjetividades dos professores universitÃrios negros da Universidade Federal do Cearà (UFC) ao longo de suas trajetÃrias de vida. O caminho percorrido rumo ao objeto de anÃlise foi conhecer e analisar as construÃÃes identitÃrias de professores dessa universidade nas experiÃncias do tornar-se negro, vivenciadas desde a infÃncia atà o ingresso no mundo do trabalho, no contÃnuo processo de identificaÃÃo e negociaÃÃo prÃprio da formaÃÃo humana. O fo...

  11. Educação política de professores: conceitos e importância

    Directory of Open Access Journals (Sweden)

    Rangel, Mary

    2005-01-01

    Full Text Available Este artigo traz aos leitores conceitos da teoria política de Hannad Arendt, demonstrando a sua relevância para a educação de professores. A argumentação do texto contempla a importância da dimensão política do magistério e dos seus fundamentos. Assim, abordam-se conceitos arendtianos sobre política, poder e violência, enfatizando-os na formação e na prática docente, seja para os professores possam incorporá-los ao processo de ensino-aprendizagem, seja para que possam exercer, de modo consciente e fundamentado, a educação para a vida cidadã

  12. A formação do professor para o ensino superior: prática docente com alunos com deficiência visual The professor educational background for the university academic practice towards visually impaired students

    Directory of Open Access Journals (Sweden)

    Michele Xavier dos Reis

    2010-04-01

    Full Text Available Apesar de existirem políticas que garantem aos alunos com necessidades educacionais especiais o acesso ao ensino regular, inúmeras barreiras são encontradas para que esse processo se efetive, sendo uma delas a formação do professor. A presente pesquisa teve como objetivo analisar a formação de professores universitários formados em Ciências Biológicas/licenciatura para o atendimento de pessoas com deficiência visual no sistema universitário. Buscando entender a formação docente como fenômeno singular e diverso, a metodologia adotada foi qualitativa, sendo selecionados cinco professores que atuavam no curso de Ciências Biológicas/licenciatura de uma universidade pública localizada no sul de Minas Gerais. Foram realizadas entrevistas semiestruturadas com os sujeitos de pesquisa, buscando averiguar a formação e a experiência docente dos sujeitos com alunos com deficiência visual. Os resultados evidenciaram que ainda são grandes as dificuldades encontradas no processo de inclusão, tanto devido a lacunas na formação docente quanto devido à postura adotada pelo professor em sala de aula.In spite of the existence of countless policies assuring impaired students access to the regular educational process, barriers are found preventing the consolidation of the mentioned process. The professor educational background is pointed out as an expressive cause to the failure of the student in the educational process. So far, the objective of the present research was to analyze the professor educational background concerning visually impaired people within the university system. The present theme is relevant considering that few studies have been dedicated to the inclusion process at advanced education. In order to understand the teaching process as a unique and diverse phenomenon, the methodology applied was qualitative and five professors, teaching Biological Sciences - graduated from a public university in the southern of Minas Gerais

  13. Os professores e a educação inclusiva: identificação dos fatores necessários à sua implementação

    Directory of Open Access Journals (Sweden)

    Marian Ávila de Lima e Dias

    2015-12-01

    Full Text Available Resumo: A pesquisa objetivou identificar fatores considerados necessários para a implementação da educação inclusiva ligados aos professores e sua atuação. Realizou-se um levantamento bibliográfico de textos acadêmicos sobre o tema; posteriormente, foram entrevistadas três professoras com experiência em educação inclusiva. A pesquisa bibliográfica identificou 20 fatores, que foram separados em três categorias: I - fatores relativos ao professor, II - fatores intraescolares e III - fatores sociais. Para as entrevistadas, a centralidade da educação inclusiva recai sobre os fatores relativos ao professor, em especial às suas características de personalidade, tais como afetividade e persistência, sem nenhuma menção aos fatores sociais. Tais respostas indicam concepções de escola e de inclusão em que o desempenho individual do professor é visto como independente do clima social e das políticas de implementação da educação inclusiva.

  14. Projeto formação continuada de professores em gênero e sexualidade: relato de experiência

    Directory of Open Access Journals (Sweden)

    Leonardo Pereira de Lima

    2015-12-01

    Full Text Available http://dx.doi.org/10.5007/1807-0221.2015v12n20p132 Este artigo relata uma atividade de formação de professores implementada a partir do Projeto de Extensão “Formação Continuada de Professores em Gênero e Sexualidade”, visando atender às dificuldades dos educadores em lidar com expressões da sexualidade que aparecem no cotidiano escolar. O projeto teve como objetivos: formar professores para atuarem com questões de gênero e sexualidade do cotidiano escolar; desconstruir mitos, tabus e preconceitos relacionados às questões de gênero e sexualidade, e instrumentalizar professores para o desenvolvimento de ações relacionadas aos temas propostos. Os cursistas relataram que sentiram-se mais instrumentalizados para mediar expressões da sexualidade do cotidiano escolar. Entendemos que o curso oferecido pelo projeto atingiu seus objetivos, promovendo algumas rupturas em posicionamentos que reduziam a sexualidade ao campo biomédico, bem como a fundamentalismos que a compreendiam de uma forma binária e mantenedora das desigualdades de gênero, permitindo que emergissem intervenções em consonância com os princípios propostos nas políticas públicas.

  15. Altered brain mechanisms of emotion processing in pre-manifest Huntington's disease.

    Science.gov (United States)

    Novak, Marianne J U; Warren, Jason D; Henley, Susie M D; Draganski, Bogdan; Frackowiak, Richard S; Tabrizi, Sarah J

    2012-04-01

    Huntington's disease is an inherited neurodegenerative disease that causes motor, cognitive and psychiatric impairment, including an early decline in ability to recognize emotional states in others. The pathophysiology underlying the earliest manifestations of the disease is not fully understood; the objective of our study was to clarify this. We used functional magnetic resonance imaging to investigate changes in brain mechanisms of emotion recognition in pre-manifest carriers of the abnormal Huntington's disease gene (subjects with pre-manifest Huntington's disease): 16 subjects with pre-manifest Huntington's disease and 14 control subjects underwent 1.5 tesla magnetic resonance scanning while viewing pictures of facial expressions from the Ekman and Friesen series. Disgust, anger and happiness were chosen as emotions of interest. Disgust is the emotion in which recognition deficits have most commonly been detected in Huntington's disease; anger is the emotion in which impaired recognition was detected in the largest behavioural study of emotion recognition in pre-manifest Huntington's disease to date; and happiness is a positive emotion to contrast with disgust and anger. Ekman facial expressions were also used to quantify emotion recognition accuracy outside the scanner and structural magnetic resonance imaging with voxel-based morphometry was used to assess the relationship between emotion recognition accuracy and regional grey matter volume. Emotion processing in pre-manifest Huntington's disease was associated with reduced neural activity for all three emotions in partially separable functional networks. Furthermore, the Huntington's disease-associated modulation of disgust and happiness processing was negatively correlated with genetic markers of pre-manifest disease progression in distributed, largely extrastriatal networks. The modulated disgust network included insulae, cingulate cortices, pre- and postcentral gyri, precunei, cunei, bilateral putamena

  16. Final Comments from Professors George and Beane.

    Science.gov (United States)

    Beane, James; George, Paul S.

    1996-01-01

    Concludes this journal focus section on curriculum integration with transcripts of questions asked by conference attendees and answers by Professors Beane and George. Areas addressed included experience levels with children and teachers, studies that point to the failure of curriculum integration, and how teachers can continue curriculum…

  17. Professor Jacques Cortes prantsuse keele lektoraadis

    Index Scriptorium Estoniae

    2000-01-01

    Juuni alguses külastas filoloogiateaduskonna romaani-germaani filoloogia osakonda Roueni ülikooli professor Jacques Cortes (Prantsusmaa). Ta korraldas 4. õa üliõpilastele prantsuse keele intensiivkursuse ja võttis vastu eksami ning kohtus prantsuse keele lektoraadi õppejõududega : [täistekst

  18. Russel Nye: The Professor in Public Life.

    Science.gov (United States)

    Hungiville, Maurice

    1995-01-01

    A discussion of the influence of Russel Nye, a college English professor at Michigan State University and journalist, focuses on the values that shaped his teaching, scholarship, and writing and his defense of democratic values, especially in education. It is concluded that Nye's experience suggests that public service can be a source of personal…

  19. Interview met professor Joan Wallach Scott

    NARCIS (Netherlands)

    Bijl, Greetje; Tijhoff, Esmeralda

    2012-01-01

    Joan Scott, professor at the School of Social Science in the Institute for Avanced Study in Princeton, New Jersey (USA), was the keynote speaker at the conference 'Uitsluitend emancipatie' in de Beurs van Berlage in Amsterdam in October 2012. An interview on gender, history, feminism and her book

  20. String theorist takes over as Lucasian Professor

    Science.gov (United States)

    Banks, Michael

    2009-11-01

    String theorist Michael Green will be the next Lucasian Professor of Mathematics at Cambridge University. Green, 63, will succeed Stephen Hawking, who held the chair from 1980 before retiring last month at the age of 67 and taking up a distinguished research chair at the Perimeter Institute for Theoretical Physics in Canada (see above).

  1. Professor Brand Advocacy: Do Brand Relationships Matter?

    Science.gov (United States)

    Jillapalli, Ravi K.; Wilcox, James B.

    2010-01-01

    The trend among students to advocate their professors online continues to generate interest within marketing academia. Brand advocacy in products and services has played a vital role in marketing. However, no known research to date has embraced the idea of brand advocacy in marketing education. This research builds on the recent human brand…

  2. CFA or CFP: A Guide for Professors

    Science.gov (United States)

    Moy, Ronald L.

    2011-01-01

    The CFA Institute and the CFP Board of Standards provide professional certifications in the field of finance. In this paper, I provide my experience with the CFA and CFP programs in order to give other professors some insight into the process of attaining the designations. I hope to provide answers to some of the questions that other faculty…

  3. Reflections of a Latino Associate Professor

    Science.gov (United States)

    Peguero, Anthony A.

    2018-01-01

    The following reflection essay is about my experiences as a Latino Associate Professor who focuses on criminology, youth violence, juvenile justice, and the associated disparities with race, ethnicity, and immigration. I reflect about the "race and justice" job market, pursuing and establishing a Latina/o Criminology working group, often…

  4. Leisure and the Retired Professor: Occupation Matters

    Science.gov (United States)

    Dorfman, Lorraine; Kolarik, Douglas

    2005-01-01

    Little attention has been given to the leisure activities of retired professors, whose activity patterns in retirement may be different from those of other occupational groups because of their lifetime commitment to work. This interview study uses both quantitative and qualitative data to investigate: (a) the leisure and professional activities of…

  5. Currículo universitário: do México ao Brasil neoliberais

    Directory of Open Access Journals (Sweden)

    Dostoiewski Mariatt de Oliveira Champangnatte

    2016-03-01

    Full Text Available Resumo O objetivo deste estudo foi discutir e comparar percepções e ações curriculares de professores universitários mexicanos e brasileiros. Contextualizando as realidades socioeconômicas dos dois países e, principalmente, as políticas governamentais voltadas ao ensino superior, observa-se, nas várias falas dos professores, uma abordagem simplista de currículo, significando-o apenas como preocupações de conteúdos administrados em disciplinas e planos de ensino. Aspectos da realidade social, política e econômica são desatrelados do pensamento e prática curriculares, onde o maior objetivo se tornou a adequação ao mercado de trabalho. Nota-se, direta e indiretamente, influências do pensamento e práticas neoliberais no posicionamento desses professores tanto quanto ao currículo como com a própria funcionalidade do ensino superior, refletindo e reproduzindo, em seus discursos e práticas, as políticas governamentais neoliberais vigentes.

  6. O RELACIONAMENTO INTERPESSOAL E AS TRANSIÇÕES DE PROFESSORES UNIVERSITÁRIOS

    Directory of Open Access Journals (Sweden)

    Fabiula Meneguete Vides da Silva

    2013-08-01

    Full Text Available Busca-se, neste trabalho, compreender o significado das relações interpessoais estabelecidas nos processos de transição do contribuidor individual (professor para líder (reitor ou pró-reitor e de líder para contribuidor individual em universidades. A abordagem fenomenológico-hermenêutica foi utilizada a fim de retomar os principais temas desta experiência. Seis ex-gestores universitários emprestaram suas experiências vivenciadas em universidades pertencentes à Associação Catarinense das Fundações Educacionais, através das entrevistas em três tempos, realizadas entre maio de 2009 e março de 2010. Somente fazendo parte da gestão universitária os professores perceberam a complexidade dessa prática. O relacionamento interpessoal foi um fator importante na prática gerencial desses professores, fato este corroborado pela literatura (MINTZBERG, 1990. Recorrendo às entrevistas transcritas, foi possível resgatar três grandes temas centrais: as relações profissionais, o relacionamento com os alunos e as relações familiares. Nas relações profissionais estabelecidas, eles perceberam a necessidade do gerenciamento do trabalho em equipe. O relacionamento frequente com os alunos fez parte do dia a dia do gestor universitário, configurando-se como um dos seus grandes desafios. A família esteve ao lado dos professores, apoiando-os e cobrando deles mais tempo de convívio familiar. Palavras-chave: Relações interpessoais. Professor universitário. Líder. Transição.

  7. Papel do professor: de Erasmo de Rotterdam a Vygotsky - Teacher's role: of Rotterdam Erasmo the Vygotsky

    Directory of Open Access Journals (Sweden)

    Ada Augusta Celestino Bezerra

    2016-09-01

    Full Text Available ResumoO artigo analisa o circuito de ideias pedagógicas sobre a função e preparação do professor ao longo da história, sob o recorte do século XVI ao século XX, a partir das contribuições de doze teóricos/filósofos da educação, do Manifesto dos Pioneiros da Educação Nova no Brasil (1932 e do Manifesto dos Educadores. O diálogo com os teóricos estabeleceu-se cronologicamente, considerando os contextos em que as obras foram publicadas e/ou difundidas, com suas implicações no papel do professor. A metodologia adotada foi a revisão bibliográfica que permitiu o retorno aos clássicos que evocaram para si o pensar sobre o processo educativo e suas relações com a sociedade. O estudo partiu de Erasmo de Rotterdam (séc. XVI até alcançar o pensamento de Vygotsky (século XX. Nas considerações finais destaca afinidades e avanços em torno da função docente, reconhecendo que está concretamente colocado à consideração e criatividade dos educadores na contemporaneidade o desafio da construção de uma educação que, mesmo situada no contexto das determinações capitalistas, forme o aluno para o exercício pleno da cidadania a partir da apropriação da cultura produzida social e historicamente pela humanidade e da radicalização do discurso neoliberal dos governos. Para esse fim aponta como componentes da formação do professor: o conhecimento científico-cultural, o conhecimento pedagógico e didático, ao lado do conhecimento profissional docente, requeridos para a inscrição na profissão de professor.    

  8. O professor diante do fracasso escolar: um estudo de caso da ideologia docente

    OpenAIRE

    Ferrarez, Silvana Tavares

    2009-01-01

    A partir do estudo de caso de uma unidade pública de ensino, esta pesquisa almejou investigar a existência de mecanismos ideológicos presentes no discurso docente a cerca do fracasso escolar das camadas menos favorecidas, buscando captar algumas das estratégias acionadas pelos professores para se eximir de qualquer responsabilidade que possa recair sobre eles quanto ao baixo rendimento escolar dos alunos. Apoiado na conexão existente entre a valorização do capital cultural e os processo de se...

  9. Um estudo sobre a apreciação do raciocínio matemático na formação inicial de professores

    OpenAIRE

    Costa, Francisca Vandilma

    2013-01-01

    O presente trabalho teve como foco desenvolver atividades de ensino, que proporcionassem, ao aluno na formação inicial de professores, uma melhoria à capacidade de raciocínio matemático e, consequentemente, uma maior apreciação dos conceitos relacionados à seção áurea, aos números irracionais, à incomensurabilidade e à demonstração da redução ao absurdo. A pesquisa classifica-se como de campo, cujos dados de coleta foram inseridos dentro de uma abordagem quanti-qualitativa. Atu...

  10. PROFESSORES DO PISA: A ESPERANÇA E A REALIZAÇÃO DA EDUCAÇÃO

    Directory of Open Access Journals (Sweden)

    Daniel Pettersson

    Full Text Available RESUMO: As atividades do Programme for International Student Assessment (PISA e os seus efeitos são diversos, sendo possível dizer que o PISA cria e forma uma fundamentação específica (HACKING, 1992 para discutir, falar e pensar sobre a educação. Neste estudo sobre as atividades do PISA, são analisadas as ideias sobre os professores, as atividades que realizam, e como estas são conceitualizadas no interior de uma narrativa própria ao PISA. Os resultados mostram que os professores são apresentados como sendo importantes e cruciais para a transformação e para o desenvolvimento da educação. Os professores também são representados como sendo essenciais para reduzir as "disparidades no desempenho" dos alunos medidas pelo teste PISA. Ademais, os "bons" professores e o ensino "eficaz" são descritos como os professores e as estratégias que conduzem a tal redução. Consequentemente, os principais relatórios do PISA enfatizam uma imagem dos professores como os atores que desenvolvem a educação e o ensino, e não como executantes de políticas determinadas pelo Estado. Deste modo, os professores são considerados como indicadores da eficácia dos sistemas de educação e importantes para elevar os padrões de desempenho, sendo assim considerados como a esperança e a realização da educação.

  11. ADAPTAÇÃO CURRICULAR PARA ALUNOS COM DEFICIÊNCIA INTELECTUAL NO RELATO DOS PROFESSORES DAS ESCOLAS ESTADUAIS PAULISTAS

    Directory of Open Access Journals (Sweden)

    Larissa Guadagnini

    2016-01-01

    Full Text Available O presente estudo analisa o relato dos professores da sala regular e da educação especial, em relação à adaptação curricular para os alunos com deficiência intelectual. A pesquisa, realizada por meio de questionários, teve como participantes 18 professores de uma diretoria de ensino do interior do estado de São Paulo, divididos entre: 8 professores da sala regular que ministraram aula no ensino fundamental para alunos com deficiência intelectual, 8 professores que ministraram aula no ensino médio para alunos com deficiência intelectual e 2 professores da educação especial. Os resultados indicaram que os professores reconhecem a importância da adaptação curricular no ensino dos alunos com deficiência intelectual, mas não tem clareza da definição do conceito e da utilização de recursos e estratégias adaptadas para favorecer a aprendizagem dos conteúdos propostos no currículo. Todavia, os dados revelaram a necessidade de as professoras compartilharem de uma visão mais ampla do como fazer adaptação dos conteúdos escolares. Tais dados indicaram a necessidade de programas direcionados à formação dos professores para atuarem na elaboração de adaptação curricular junto aos alunos com deficiência intelectual. Palavras-Chave: Educação Especial. Currículo. Deficiência intelectual. Inclusão escolar.

  12. Categorization of Quantum Mechanics Problems by Professors and Students

    Science.gov (United States)

    Lin, Shih-Yin; Singh, Chandralekha

    2010-01-01

    We discuss the categorization of 20 quantum mechanics problems by physics professors and undergraduate students from two honours-level quantum mechanics courses. Professors and students were asked to categorize the problems based upon similarity of solution. We also had individual discussions with professors who categorized the problems. Faculty…

  13. 22 CFR 62.20 - Professors and research scholars.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professors and research scholars. 62.20 Section... Specific Program Provisions § 62.20 Professors and research scholars. (a) Introduction. These regulations govern Exchange Visitor Program participants in the categories of professor and research scholar, except...

  14. Variables That Can Affect Student Ratings of Their Professors

    Science.gov (United States)

    Gotlieb, Jerry

    2013-01-01

    Attribution theory was applied to help predict the results of an experiment that examined the effects of three independent variables on students' ratings of their professors. The dependent variables were students' perceptions of whether the professor caused the students' grades and student satisfaction with their professor. The results suggest…

  15. E-Mail from Professor Enhances Student Motivation and Attitudes

    Science.gov (United States)

    Legg, Angela M.; Wilson, Janie H.

    2009-01-01

    Traditionally, professors use the first day of class to build rapport. However, current technology allows professors to contact students prior to the first day of class. This study assessed how the receipt of a welcoming e-mail from a female professor 1 week before the first day of class affected student motivation and attitudes toward the…

  16. Influências do "Projeto de Ensino Flora Fanerogâmica do Estado de São Paulo" na formação dos professores participantes em uma escola da cidade de Campinas

    OpenAIRE

    Lilian Pereira Cruz

    2010-01-01

    Resumo: O Projeto "Flora Fanerogamica do Estado de Sao Paulo" (FFESP) teve inicio em 1993, com o objetivo de estudar a vegetacao paulista. Em 1997, foi apresentado aos professores de duas escolas publicas de Ensino Fundamental: uma de Campinas e outra de Santos, e duas escolas, tambem publicas, de Ensino Medio: uma de Sao Carlos e outra de Sao Paulo. Em Campinas, o projeto foi desenvolvido com a participacao de professores das disciplinas de Ciencias, Portugues, Artes, Historia e Geografia em...

  17. Educação superior e agenciamento: a constituição singular do professor da educação superior no presente

    Directory of Open Access Journals (Sweden)

    Daniela Pederiva Pensin

    2017-10-01

    Full Text Available O texto toma como objeto a constituição do professor da educação superior considerando a complexidade do presente. Ao intentar sua problematização, o faz inspirado nos estudos de orientação foucaultiana, servindo-se do discurso como conceito teórico-metodológico. A busca por este objetivo mobilizou: reconhecer a constituição do professor da educação superior inextrincavelmente articulada à constituição da docência; assentir a constituição histórica e contextualizada deste professor; tomá-la em sua singularidade na invenção de um tipo sujeito específico; dar visibilidade ao que se coloca como verdades sobre este professor por meio dos discursos institucionais. Tomou-se como superfície analítica os Projetos Pedagógicos Institucionais de nove universidades do Rio Grande do Sul e buscou-se pelas recorrências discursivas ─ formas de fazer circular verdades autorizadas que, em meio a jogos de verdade, constituem o professor. Organizado em duas seções, na primeira trata a constituição do professor desde uma perspectiva histórica, que permite ver o professor imerso na atmosfera da educação de seu tempo numa constituição não estática, tampouco linear. A segunda seção traz a compreensão de que o professor, no presente, constitui-se em meio a práticas de uma docência singular, que opera pelo agenciamento. O movimento analítico que sustenta este texto conduz à compreensão de que o professor se constitui, no presente, como um sujeito que opera pelo agenciamento e ao operar mobiliza a ideia de fazer do indivíduo alguém capaz de produzir efeitos, ao menos, em três dimensões: (1 uma dimensão de mercado, (2 uma dimensão de conhecimento e tecnologia, (3 uma dimensão humanizadora.

  18. [Professor WU Zhongchao's experience of penetration needling].

    Science.gov (United States)

    Zhang, Ning; Wang, Bing; Zhou, Yu

    2016-08-12

    Professor WU Zhongchao has unique application of penetration needling in clinical treatment. Professor WU applies penetration needling along meridians, and the methods of penetration needling include self-meridian penetration, exterior-interior meridian penetration, identical-name meridian penetration, different meridian penetration. The meridian differentiation is performed according to different TCM syndromes, locations and natures of diseases and acupoint nature, so as to make a comprehensive assessment. The qi movement during acupuncture is focused. In addition, attention is paid on anatomy and long-needle penetration; the sequence and direction of acupuncture is essential, and the reinforcing and reducing methods have great originality, presented with holding, waiting, pressing and vibrating. Based on classical acupoint, the acupoint of penetration needling is flexible, forming unique combination of acupoints.

  19. Professor Andrzej Nespiak (1921-1981

    Directory of Open Access Journals (Sweden)

    Tomasz Majewski

    2014-08-01

    Full Text Available The biography of a professor of the Laboratory of Pharmaceutical Botany of the Medical Academy in Wrocław, who was formerly an investigator of the Agricultural Academy in Wrocław. He worked on mycorhiza, the participation of Macromycetes in forest communities and the use of fungi for synthesis of some organic compounds, he was also the author of the Polish flora of the genus Cortinarius (1975,1981 and Inocybe (manuscript.

  20. Professor Andrzej Nespiak (1921-1981)

    OpenAIRE

    Tomasz Majewski

    2014-01-01

    The biography of a professor of the Laboratory of Pharmaceutical Botany of the Medical Academy in Wrocław, who was formerly an investigator of the Agricultural Academy in Wrocław. He worked on mycorhiza, the participation of Macromycetes in forest communities and the use of fungi for synthesis of some organic compounds, he was also the author of the Polish flora of the genus Cortinarius (1975,1981) and Inocybe (manuscript).

  1. [Homage to Professor Dr. Nicasio Etchepareborda].

    Science.gov (United States)

    1998-11-01

    During a solemn academic act, de Main Classroom of the Facultad de Odontologia de Buenos Aires was named after Prof. Dr. Nicasio Etchepareborda. He has been the first professor at the Escuela de Odontologia and its organizer, after having obtained his Dentistry degree at the Dental School of Paris, in 1882. The new school was founded in 1891, and its activities began the following year.

  2. 31 July 2014 - Professor M. Kastner

    CERN Multimedia

    Egli, Laurent

    2014-01-01

    MIT Faculty Member Donner Professor of Physics Massachusetts Institute of Technology United States of America, Prof. M. Kastner visiting the LHC tunnel at Point 5 with Beams Department M. Solfaroli Camillocci, LHC superconducting magnet assembly hall visit with L. Rossi and R. Principe, LHC Computing Grid Project presentation and computer centre visit with I. Bird and signing the guest book with CERN Director-General R. Heuer.

  3. Work process of nursing professors 1

    Science.gov (United States)

    Parra Giordano, Denisse; Felli, Vanda Elisa Andres

    2017-01-01

    ABSTRACT Objective: to analyze the work process of nursing professors. Method: descriptive, exploratory and qualitative study, developed with a focus on critical epidemiology, carried out at a School of Nursing in Chile. The research subjects consist of 17 nursing professors, with whom individual semi-structured interviews were carried out and nine participated in a focus group. The Ethics Committee approved this study. Results: 88.2% were female, mean age of 42 years, 47% were married, 94% were Chilean, average length of service in the institution of 2.8 years, and 23.5% had a master’s degree. Regarding the work process, the students were the work object, the tools used were the knowledge and the experience as a nurse, and the work environment was considered good. Regarding the form of work organization, 76% have a 44-hour workweek, the wage was considered inadequate and the workload was higher than foreseen in the contract. The dialectic of the nursing work process is evidenced, demonstrating the contradiction between the low wages and labor overload and the narratives reporting a good work environment, personal fulfillment and transcendence that goes far beyond work. Conclusions: the work process allows describing the work components of the nursing professors, which are consistent with the results of the literature and show the dialectic of the nursing work process. PMID:29211193

  4. Professor Witold Nowicki - a greatly spirited pathologist.

    Science.gov (United States)

    Wincewicz, A; Szepietowska, A; Sulkowski, S

    2016-06-01

    This paper presents a complete overview of the scientific, professional and social activity of a great Polish pathologist, Witold Nowicki (1878-1941), from mainly Polish-written, original sources with a major impact on mostly his own publications. The biographical commemoration of this eminent professor is not only due to the fact that he provided a profound microscopic characterization of pneumatosis cystoides in 1909 and 1924. Nowicki greatly influenced the development of anatomical pathology in Poland, having authored over 82 publications, with special reference to tuberculosis, lung cancer, sarcomatous carcinomas, scleroma and others. However, the first of all his merits for the readership of Polish pathologists was his textbook titled Anatomical Pathology, which was a basic pathology manual in pre-war Poland. Witold Nowicki - as the head of the academic pathological anatomy department and former dean of the medical faculty - was shot with other professors by Nazi Germans in the Wuleckie hills in Lvov during World War Two. Professor Nowicki was described as being "small in size but great in spirit" by one of his associates, and remains an outstanding example of a meticulous pathologist, a patient tutor and a great social activist to follow.

  5. O professor_: de quem estamos falando mesmo?

    Directory of Open Access Journals (Sweden)

    Santos, Fabiane Konowaluk

    2004-01-01

    Full Text Available O presente texto procura abordar a temática relacionada à auto-imagem do professor, constatada através de uma enquete e da construção de um website que subsidiou o tensionamento com o real. Segundo Arroyo (2000, p. 124, “carregamos a função que exercemos, que somos e a imagem de professor(a que internalizamos”. Dessa forma, o tema em estudo segue, ainda hoje, sendo altamente significativo, pois não podemos esquecer os momentos históricos, políticos e sociais vivenciados pelos professores, buscando justamente explicações sobre como as questões de auto-imagem, o fazer e suas competências, suas possibilidades e limites e outros tantos fatores que estão a alterar seu comportamento. Arroyo (2000, p. 124 assinala que a auto-imagem docente é apreendida em múltiplos espaços e tempos, em múltiplas vivências, como resultado das condições psicológicas e sociais que afetam sua docência

  6. Huntington Disease - principles and practice of nutritional management.

    Science.gov (United States)

    Zukiewicz-Sobczak, Wioletta; Król, Renata; Wróblewska, Paula; Piątek, Jacek; Gibas-Dorna, Magdalena

    2014-01-01

    Huntington disease (HD) is a degenerative brain disease clinically manifested by the characteristic triad: physical symptoms including involuntary movements and poor coordination, cognitive changes with less ability to organize routine tasks, and some emotional and behavioral disturbances. For patients with HD, feeding is one of the problems they have to face. People with HD often have lower than average body weight and struggle with malnutrition. As a part of therapy, good nutrition is an intervention maintaining health and functional ability for maximally prolonged time. In the early stages of HD, small amounts of blenderized foods given orally are recommended. In more advanced stages, enteral nutrition is essential using gastric, or jejunal tubes for short term. Most severe cases require gastrostomy or gastrojejunostomy. Although enteral feeding is well tolerated by most of the patients, a number of complications may occur, including damage to the nose, pharynx, or esophagus, aspiration pneumonia, sinusitis, metabolic imbalances due to improper nutrient and fluid supply, adverse effects affecting gastrointestinal system, and refeeding syndrome. Copyright © 2014 Polish Neurological Society. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  7. The story of George Huntington and his disease

    Directory of Open Access Journals (Sweden)

    Kalyan B Bhattacharyya

    2016-01-01

    Full Text Available George Huntington described some families with choreiform movements in 1872 in the United States of America and since then many such families have been described in other parts of the world and works on the genetics of the disease have brought new vistas in the understanding of the disease. In 1958, Americo Negrette, a young Venezuelan physician observed similar subjects in the vicinity of Lake Maracaibo which was presented by his co-worker, Ramon Avilla Giron at New York in 1972 when United States of America had been commemorating the centenary year of Huntington′s disease. Nancy Wexler, a psychoanalyst, whose mother had been suffering from the disease attended the meeting and organized a research team to Venezuela and they systematically studied more than 18,000 individuals in order to work out a common pedigree. They identified the genetic locus of the disease in the short arm of chromosome 4 and observed that it was a trinucleotide repeat disorder.

  8. Bradykinesia in Huntington's disease. A prospective, follow-up study.

    Science.gov (United States)

    García Ruiz, Pedro J; Hernández, Jaime; Cantarero, Susana; Bartolomé, Manuel; Sánchez Bernardos, Vicenta; García de Yébenez, Justo

    2002-04-01

    Bradykinesia is a frequent finding in Huntington's disease (HD), but some aspects are presently unknown; including the natural evolution of bradykinesia over time and the correlation between bradykinesia and functional capacity. We studied the motor performance of 20 genetically confirmed patients with HD (age: 40+/-10.8 years; age at onset 33.6+/-11 years; total functional capacity (TFC): 9.57+/-3; UHDRS total motor scale: 31.4+/-13, triplet length (CAG)n: 46.7+/-4 triplets). These patients were studied in baseline conditions and after 18.7+/-6 months of follow-up. In addition, HD patients were compared with 20 age-matched normal controls. Motor study included the four CAPIT timed tests commonly used for Parkinson's disease: pronation-supination (PS), finger dexterity (FD), movement between two points (MTP) and walking test (WT). HD patients were significantly slower than controls in all motor tasks. A significant deterioration occurred over time in three of the four motor tasks (especially FD and WT). A significant correlation between timed tests and TFC score was found (for MTP, r: -0.845; p < 0,0001). In addition a significant correlation between timed tests and the UHDRDS total motor scale was also found (for MTP, r: 0.864; p < 0.0001). In conclusion, simple timed motor tests can detect a deterioration of motor activity over time in HD. Timed tests might be useful to follow the natural evolution of HD and to assess the efficacy of new therapies.

  9. Medical management of motor manifestations of Huntington disease.

    Science.gov (United States)

    McCusker, Elizabeth A; Loy, Clement T

    2017-01-01

    The motor and movement disorders of Huntington disease (HD) are managed in the context of the other disease features. Chorea and dystonia are the most common HD-associated movement disorders, and they can be assessed on research rating scales. However other motor manifestations have a significant impact. In particular, dysphagia influences choice and tolerance of treatment for the movement disorder, as will comorbidities, patient awareness, and distress related to the motor feature or movement. Treatment for other disease features may aggravate the motor disorder, e.g., increased swallowing difficulty associated with antipsychotic agents. Basic principles in deciding to institute a treatment are outlined as well as treatment of specific motor manifestations and movements. There is a paucity of evidence to support the treatments available for the motor disorder, with only one agent with class 1 evidence, tetrabenazine, for chorea. There are, however, treatments informed by expert opinion which reflect the management of a wider HD phenotype than that represented in clinical trials. Some treatments are based on evidence from use in other conditions. Medical management is usually undertaken later in the disease with concurrent nonmedical interventions after multidisciplinary assessments. Medication review with HD progression is essential. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Pitfalls in the detection of cholesterol in Huntington's disease models.

    Science.gov (United States)

    Marullo, Manuela; Valenza, Marta; Leoni, Valerio; Caccia, Claudio; Scarlatti, Chiara; De Mario, Agnese; Zuccato, Chiara; Di Donato, Stefano; Carafoli, Ernesto; Cattaneo, Elena

    2012-10-11

    Background Abnormalities in brain cholesterol homeostasis have been reported in Huntington's disease (HD), an adult-onset neurodegenerative disorder caused by an expansion in the number of CAG repeats in the huntingtin (HTT) gene. However, the results have been contradictory with respect to whether cholesterol levels increase or decrease in HD models. Biochemical and mass spectrometry methods show reduced levels of cholesterol precursors and cholesterol in HD cells and in the brains of several HD animal models. Abnormal brain cholesterol homeostasis was also inferred from studies in HD patients. In contrast, colorimetric and enzymatic methods indicate cholesterol accumulation in HD cells and tissues. Here we used several methods to investigate cholesterol levels in cultured cells in the presence or absence of mutant HTT protein. Results Colorimetric and enzymatic methods with low sensitivity gave variable results, whereas results from a sensitive analytical method, gas chromatography-mass spectrometry, were more reliable. Sample preparation, high cell density and cell clonality also influenced the detection of intracellular cholesterol. Conclusions Detection of cholesterol in HD samples by colorimetric and enzymatic assays should be supplemented by detection using more sensitive analytical methods. Care must be taken to prepare the sample appropriately. By evaluating lathosterol levels using isotopic dilution mass spectrometry, we confirmed reduced cholesterol biosynthesis in knock-in cells expressing the polyQ mutation in a constitutive or inducible manner. *Correspondence should be addressed to Elena Cattaneo: elena.cattaneo@unimi.it.

  11. Mitochondrial DNA levels in Huntington disease leukocytes and dermal fibroblasts.

    Science.gov (United States)

    Jędrak, Paulina; Krygier, Magdalena; Tońska, Katarzyna; Drozd, Małgorzata; Kaliszewska, Magdalena; Bartnik, Ewa; Sołtan, Witold; Sitek, Emilia J; Stanisławska-Sachadyn, Anna; Limon, Janusz; Sławek, Jarosław; Węgrzyn, Grzegorz; Barańska, Sylwia

    2017-08-01

    Huntington disease (HD) is an inherited neurodegenerative disorder caused by mutations in the huntingtin gene. Involvement of mitochondrial dysfunctions in, and especially influence of the level of mitochondrial DNA (mtDNA) on, development of this disease is unclear. Here, samples of blood from 84 HD patients and 79 controls, and dermal fibroblasts from 10 HD patients and 9 controls were analysed for mtDNA levels. Although the type of mitochondrial haplogroup had no influence on the mtDNA level, and there was no correlation between mtDNA level in leukocytes in HD patients and various parameters of HD severity, some considerable differences between HD patients and controls were identified. The average mtDNA/nDNA relative copy number was significantly higher in leukocytes, but lower in fibroblasts, of symptomatic HD patients relative to the control group. Moreover, HD women displayed higher mtDNA levels in leukocytes than HD men. Because this is the largest population analysed to date, these results might contribute to explanation of discrepancies between previously published studies concerning levels of mtDNA in cells of HD patients. We suggest that the size of the investigated population and type of cells from which DNA is isolated could significantly affect results of mtDNA copy number estimation in HD. Hence, these parameters should be taken into consideration in studies on mtDNA in HD, and perhaps also in other diseases where mitochondrial dysfunction occurs.

  12. Cognitive and behavioral changes in Huntington disease before diagnosis.

    Science.gov (United States)

    Paulsen, Jane S; Miller, Amanda C; Hayes, Terry; Shaw, Emily

    2017-01-01

    Phenotypic manifestations of Huntington disease (HD) can be detected at least 15 years prior to the time when a motor diagnosis is given. Advances in clinical care and future research will require consistent use of HD definitions and HD premanifest (prodromal) stages being used across clinics, sites, and countries. Cognitive and behavioral (psychiatric) changes in HD are summarized and implications for ongoing advancement in our knowledge of prodromal HD are suggested. The earliest detected cognitive changes are observed in the Symbol Digit Modalities Test, Stroop Interference, Stroop Color and Word Test-interference condition, and Trail Making Test. Cognitive changes in the middle and near motor diagnostic stages of prodromal HD involve nearly every cognitive test administered and the greatest changes over time (i.e., slopes) are found in those prodromal HD participants who are nearest to motor diagnosis. Psychiatric changes demonstrate significant worsening over time and remain elevated compared with healthy controls throughout the prodromal disease course. Psychiatric and behavior changes in prodromal HD are much lower than that obtained using cognitive assessment, although the psychiatric and behavioral changes represent symptoms most debilitating to independent capacity and wellness. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Controlled clinical trial of cannabidiol in Huntington's disease.

    Science.gov (United States)

    Consroe, P; Laguna, J; Allender, J; Snider, S; Stern, L; Sandyk, R; Kennedy, K; Schram, K

    1991-11-01

    Based on encouraging preliminary findings, cannabidiol (CBD), a major nonpsychotropic constituent of Cannabis, was evaluated for symptomatic efficacy and safety in 15 neuroleptic-free patients with Huntington's Disease (HD). The effects of oral CBD (10 mg/kg/day for 6 weeks) and placebo (sesame oil for 6 weeks) were ascertained weekly under a double-blind, randomized cross-over design. A comparison of the effects of CBD and placebo on chorea severity and other therapeutic outcome variables, and on a Cannabis side effect inventory, clinical lab tests and other safety outcome variables, indicated no significant (p greater than 0.05) or clinically important differences. Correspondingly, plasma levels of CBD were assayed by GC/MS, and the weekly levels (mean range of 5.9 to 11.2 ng/ml) did not differ significantly over the 6 weeks of CBD administration. In summary, CBD, at an average daily dose of about 700 mg/day for 6 weeks, was neither symptomatically effective nor toxic, relative to placebo, in neuroleptic-free patients with HD.

  14. Total recognition discriminability in Huntington's and Alzheimer's disease.

    Science.gov (United States)

    Graves, Lisa V; Holden, Heather M; Delano-Wood, Lisa; Bondi, Mark W; Woods, Steven Paul; Corey-Bloom, Jody; Salmon, David P; Delis, Dean C; Gilbert, Paul E

    2017-03-01

    Both the original and second editions of the California Verbal Learning Test (CVLT) provide an index of total recognition discriminability (TRD) but respectively utilize nonparametric and parametric formulas to compute the index. However, the degree to which population differences in TRD may vary across applications of these nonparametric and parametric formulas has not been explored. We evaluated individuals with Huntington's disease (HD), individuals with Alzheimer's disease (AD), healthy middle-aged adults, and healthy older adults who were administered the CVLT-II. Yes/no recognition memory indices were generated, including raw nonparametric TRD scores (as used in CVLT-I) and raw and standardized parametric TRD scores (as used in CVLT-II), as well as false positive (FP) rates. Overall, the patient groups had significantly lower TRD scores than their comparison groups. The application of nonparametric and parametric formulas resulted in comparable effect sizes for all group comparisons on raw TRD scores. Relative to the HD group, the AD group showed comparable standardized parametric TRD scores (despite lower raw nonparametric and parametric TRD scores), whereas the previous CVLT literature has shown that standardized TRD scores are lower in AD than in HD. Possible explanations for the similarity in standardized parametric TRD scores in the HD and AD groups in the present study are discussed, with an emphasis on the importance of evaluating TRD scores in the context of other indices such as FP rates in an effort to fully capture recognition memory function using the CVLT-II.

  15. Therapeutic approaches to preventing cell death in Huntington disease.

    Science.gov (United States)

    Kaplan, Anna; Stockwell, Brent R

    2012-12-01

    Neurodegenerative diseases affect the lives of millions of patients and their families. Due to the complexity of these diseases and our limited understanding of their pathogenesis, the design of therapeutic agents that can effectively treat these diseases has been challenging. Huntington disease (HD) is one of several neurological disorders with few therapeutic options. HD, like numerous other neurodegenerative diseases, involves extensive neuronal cell loss. One potential strategy to combat HD and other neurodegenerative disorders is to intervene in the execution of neuronal cell death. Inhibiting neuronal cell death pathways may slow the development of neurodegeneration. However, discovering small molecule inhibitors of neuronal cell death remains a significant challenge. Here, we review candidate therapeutic targets controlling cell death mechanisms that have been the focus of research in HD, as well as an emerging strategy that has been applied to developing small molecule inhibitors-fragment-based drug discovery (FBDD). FBDD has been successfully used in both industry and academia to identify selective and potent small molecule inhibitors, with a focus on challenging proteins that are not amenable to traditional high-throughput screening approaches. FBDD has been used to generate potent leads, pre-clinical candidates, and has led to the development of an FDA approved drug. This approach can be valuable for identifying modulators of cell-death-regulating proteins; such compounds may prove to be the key to halting the progression of HD and other neurodegenerative disorders. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. Predictive gene testing for Huntington disease and other neurodegenerative disorders.

    Science.gov (United States)

    Wedderburn, S; Panegyres, P K; Andrew, S; Goldblatt, J; Liebeck, T; McGrath, F; Wiltshire, M; Pestell, C; Lee, J; Beilby, J

    2013-12-01

    Controversies exist around predictive testing (PT) programmes in neurodegenerative disorders. This study sets out to answer the following questions relating to Huntington disease (HD) and other neurodegenerative disorders: differences between these patients in their PT journeys, why and when individuals withdraw from PT, and decision-making processes regarding reproductive genetic testing. A case series analysis of patients having PT from the multidisciplinary Western Australian centre for PT over the past 20 years was performed using internationally recognised guidelines for predictive gene testing in neurodegenerative disorders. Of 740 at-risk patients, 518 applied for PT: 466 at risk of HD, 52 at risk of other neurodegenerative disorders - spinocerebellar ataxias, hereditary prion disease and familial Alzheimer disease. Thirteen percent withdrew from PT - 80.32% of withdrawals occurred during counselling stages. Major withdrawal reasons related to timing in the patients' lives or unknown as the patient did not disclose the reason. Thirty-eight HD individuals had reproductive genetic testing: 34 initiated prenatal testing (of which eight withdrew from the process) and four initiated pre-implantation genetic diagnosis. There was no recorded or other evidence of major psychological reactions or suicides during PT. People withdrew from PT in relation to life stages and reasons that are unknown. Our findings emphasise the importance of: (i) adherence to internationally recommended guidelines for PT; (ii) the role of the multidisciplinary team in risk minimisation; and (iii) patient selection. © 2013 The Authors; Internal Medicine Journal © 2013 Royal Australasian College of Physicians.

  17. Constitutive upregulation of chaperone-mediated autophagy in Huntington's disease.

    Science.gov (United States)

    Koga, Hiroshi; Martinez-Vicente, Marta; Arias, Esperanza; Kaushik, Susmita; Sulzer, David; Cuervo, Ana Maria

    2011-12-14

    Autophagy contributes to the removal of prone-to-aggregate proteins, but in several instances these pathogenic proteins have been shown to interfere with autophagic activity. In the case of Huntington's disease (HD), a congenital neurodegenerative disorder resulting from mutation in the huntingtin protein, we have previously described that the mutant protein interferes with the ability of autophagic vacuoles to recognize cytosolic cargo. Growing evidence supports the existence of cross talk among autophagic pathways, suggesting the possibility of functional compensation when one of them is compromised. In this study, we have identified a compensatory upregulation of chaperone-mediated autophagy (CMA) in different cellular and mouse models of HD. Components of CMA, namely the lysosome-associated membrane protein type 2A (LAMP-2A) and lysosomal-hsc70, are markedly increased in HD models. The increase in LAMP-2A is achieved through both an increase in the stability of this protein at the lysosomal membrane and transcriptional upregulation of this splice variant of the lamp-2 gene. We propose that CMA activity increases in response to macroautophagic dysfunction in the early stages of HD, but that the efficiency of this compensatory mechanism may decrease with age and so contribute to cellular failure and the onset of pathological manifestations.

  18. Huntington's disease in Greece: the experience of 14 years.

    Science.gov (United States)

    Panas, M; Karadima, G; Vassos, E; Kalfakis, N; Kladi, A; Christodoulou, K; Vassilopoulos, D

    2011-12-01

    A large scale genetic and epidemiological study of Huntington's disease (HD) was carried out in Greece from January 1995 to December 2008. Diagnostic testing was carried out in 461 symptomatic individuals, while 256 were tested for presymptomatic purposes. The diagnosis of HD with a CAG expansion ≥ 36 was confirmed in 278 symptomatic individuals. The prevalence of HD in Greece was estimated at approximately 2.5 to 5.4:100,000, while the mean minimum incidence was estimated at 2.2 to 4.4 per million per year. The molecular diagnosis of HD was confirmed in the majority of patients (84.4%) sent for confirmation. The false-positive cases 15.6% were characterized by the absence of a family history of HD and the presence of an atypical clinical picture. The uptake of predictive testing for HD was 8.6%. A prenatal test was requested in six pregnancies. The findings of our study do not differ significantly from those of similar studies from other European countries despite the relative genetic isolation of Greece. Of interest is the identification of clusters of HD in Greece. The presence or absence of a family history of HD should be interpreted cautiously, during the diagnostic process. © 2010 John Wiley & Sons A/S.

  19. Plasma homovanillic acid and prolactin in Huntington's disease.

    Science.gov (United States)

    Markianos, Manolis; Panas, Marios; Kalfakis, Nikos; Vassilopoulos, Dimitrios

    2009-05-01

    Dopaminergic activity is expected to be altered in patients with Huntington's disease (HD) and be related to factors like duration and severity of illness or patients' specific symptomatology like dementia, depression, or psychotic features. We assessed plasma homovanillic acid (pHVA) and plasma prolactin (pPRL), two correlates of dopaminergic activity, in 116 subjects with CAG repeats expansion in the HD gene, 26 presymptomatic (18 females) and 90 with overt symptomatology (43 females). Patients were evaluated using the Unified HD Rating Scale and the Total Functional Capacity Scale. Presence of dementia, depression, and psychotic features were also assessed. The age range of the patients was 22-83 years, duration of illness from 0.5 to 27 years, and CAG repeat number from 34 to 66. A group of 60 age and sex matched healthy subjects served as control group. Plasma PRL in subjects at risk and in neuroleptic-free patients, evaluated separately for males and females, did not differ from controls. Plasma HVA levels did not differ from controls in the group of presymptomatic subjects, but were significantly higher in the patients group. This increase was positively associated mainly with severity of illness and functional capacity of the patients, and not with presence of depression or dementia. Plasma HVA levels may be proven to be a peripheral index of disease progression. Reducing dopaminergic activity may have not only symptomatic, but also neuroprotective effects in HD.

  20. Cartas ao mar... De experiências que nos habitam: Narrativas de formação docente

    OpenAIRE

    Henriques, Eda Maria de Oliveira; de Azevedo, Mônica Maria

    2018-01-01

    Este trabalho pretende, através de um relato parcial de seu desenvolvimento e resultados, discutir e analisar a importância das narrativas de formação de professores no âmbito da pesquisa educacional. Nessa perspectiva, a pesquisa aqui relatada foi realizada em uma escola da rede pública de ensino do DF, Brasília, que atende o segmento do ensino fundamental de primeiro ao quinto ano e buscou identificar e analisar concepções de professores de ensino básico sobre suas experiências de leitura a...

  1. Professor numa ação Coach: a busca do ensino e da eficiência

    Directory of Open Access Journals (Sweden)

    Valéria Guedes Caruso

    2014-08-01

    Full Text Available Reconhecendo colocações de parceiros, colegas e do mundo globalizado, observamos o contexto de trabalho do profissional professor quanto às cobranças e o fraco reconhecimento, que grande parte sofre, quanto ao produto de seu trabalho. Trabalho que dentro das limitações, que os esquemas impõem, pouco tem se apresentado como diferencial para quem é sujeito de nosso trabalho. De certo modo, objetivando alternativas que possam validar e valorizar o trabalho desenvolvido pelo docente, apresentamos como alternativa complementar nossa ação com técnicas de coching. Remetemos a antiguidade para justificar que tal idéia há muito nos foi apresentada, mas somente no final do século passado tomamos maior consciência de sua utilidade e do significativo retorno que disponibiliza ao docente, como ao discente. A ação educativa que a técnica coching possibilita aos alunos se aproxima da pratica que o mercado de trabalho quer cobrar e ver desenvolvido por seus profissionais. Mas, devemos deixar claro que requer do professor uma reavaliação quanto a técnicas, envolvimento, desenvolvimento de seu próprio conhecimento e tudo que venha a contribuir para o seu desempenho.

  2. A Politecnia nos Discursos Coletivos dos Professores do Ensino Médio Politécnico

    Directory of Open Access Journals (Sweden)

    Maria de Fatima Baldez Rodrigues

    2017-12-01

    Full Text Available Este trabalho discute a compreensão de politecnia no discurso coletivo de um grupo de 52 professores do 1º ano de 13 escolas do Ensino Médio Politécnico, de um município do Estado Rio Grande do Sul. No segundo semestre de 2016 e primeiro de 2017, foi realizada uma entrevista com um professor de cada área do conhecimento. O material discursivo foi analisado com a técnica do Discurso do Sujeito Coletivo – DSC. No discurso sobre a compreensão de politecnia, os professores apresentam questionamentos que evidenciam uma não apropriação desse conceito, delegando à equipe diretiva a responsabilidade por explicar o mesmo. Associam a politecnia ao ensino de diversas técnicas que preparam para o mercado de trabalho ou a integração das áreas do conhecimento. O estudo aponta que as diferentes propostas de reestruturação curriculares implementadas, como a do Ensino Médio Politécnico (2012 e a Base Nacional Comum Curricular (2017 são capazes de gerar confusão entre culturas por trazerem à tona questionamentos sobre as ideias, tecnologias e organização social da escola e potencializar o surgimento de outras culturas de formação docente.

  3. Relacionamento professor-aluno e auto-regulação da aprendizagem no 3º ciclo do ensino médio português

    Directory of Open Access Journals (Sweden)

    Ângela Sá Azevedo

    2012-08-01

    Full Text Available Este artigo teve como objetivo explorar a relação entre a percepção do comportamento do professor e auto-regulação da aprendizagem na Matemática. As respostas de 625 alunos do 3ºciclo do Ensino Médio Português (7º ao 9º anos aos questionários QIPBásico e IPAAr permitiram perceber diferenças nas variáveis supracitadas em função do sexo, da idade, do ano de escolaridade e do número de retenções, do nível educacional dos pais, do sexo do professor de Matemática e do número de anos com o mesmo professor. As conclusões mais relevantes para a prática pedagógica prendem-se à relação positiva entre a auto-regulação da aprendizagem dos alunos e a percepção de liderança, apoio e compreensão por parte dos professores, e relação negativa entre a auto-regulação e a percepção de insatisfação, insegurança e repreensão dos seus professores.

  4. Marcas no corpo, cansaço e experiência: nuances do envelhecer como professor de Educação Física

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    Sílvia Maria Agatti Lüdorf

    2013-09-01

    Full Text Available Este trabalho objetivou compreender e interpretar os significados que os professores de Educação Física atribuem ao corpo e envelhecimento, e investigar como tais representações influenciariam sua prática profissional. Participaram da investigação, de natureza qualitativa, 43 professores de escolas e academias de ginástica com cerca de trinta anos de formação. Os dados foram tratados mediante análise de conteúdo. O envelhecimento do professor propicia maturidade, experiência e confiança no trabalho, mas o corpo físico parece desprender-se do sujeito, repercutindo em sentimentos contraditórios relacionados ao envelhecimento. Nas academias, há certo ajuste ao contexto da visibilidade, pois são valorizadas as potencialidades e as marcas de saúde impressas no corpo. Já o desgaste e o cansaço são particularmente sentidos pelos professores atuantes em escola.

  5. A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease.

    Directory of Open Access Journals (Sweden)

    Eirini Kalliolia

    Full Text Available Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to hypothalamic pathology and dysfunction of hypothalamo-pituitary axes.We studied neuroendocrine profiles of corticotropic, somatotropic and gonadotropic hypothalamo-pituitary axes hormones over a 24-hour period in controlled environment in 15 healthy controls, 14 premanifest and 13 stage II/III Huntington's disease subjects. We also quantified fasting levels of vasopressin, oestradiol, testosterone, dehydroepiandrosterone sulphate, thyroid stimulating hormone, free triiodothyronine, free total thyroxine, prolactin, adrenaline and noradrenaline. Somatotropic axis hormones, growth hormone releasing hormone, insulin-like growth factor-1 and insulin-like factor binding protein-3 were quantified at 06:00 (fasting, 15:00 and 23:00. A battery of clinical tests, including neurological rating and function scales were performed.24-hour concentrations of adrenocorticotropic hormone, cortisol, luteinizing hormone and follicle-stimulating hormone did not differ significantly between the Huntington's disease group and controls. Daytime growth hormone secretion was similar in control and Huntington's disease subjects. Stage II/III Huntington's disease subjects had lower concentration of post-sleep growth hormone pulse and higher insulin-like growth factor-1:growth hormone ratio which did not reach significance. In Huntington's disease subjects, baseline levels of hypothalamo-pituitary axis hormones measured did not significantly differ from those of healthy controls.The relatively small subject group means that the study may not detect subtle perturbations in hormone concentrations. A targeted study of the somatotropic axis in larger cohorts may be warranted. However, the lack of significant results despite many

  6. Music therapy in Huntington's disease: a protocol for a multi-center randomized controlled trial.

    Science.gov (United States)

    van Bruggen-Rufi, Monique; Vink, Annemieke; Achterberg, Wilco; Roos, Raymund

    2016-07-26

    Huntington's disease is a progressive, neurodegenerative disease with autosomal dominant inheritance, characterized by motor disturbances, cognitive decline and behavioral and psychological symptoms. Since there is no cure, all treatment is aimed at improving quality of life. Music therapy is a non-pharmacological intervention, aiming to improve the quality of life, but its use and efficacy in patients with Huntington's disease has hardly been studied. In this article, a protocol is described to study the effects of music therapy in comparison with a control intervention to improve quality of life through stimulating expressive and communicative skills. By targeting these skills we assume that the social-cognitive functioning will improve, leading to a reduction in behavioral problems, resulting in an overall improvement of the quality of life in patients with Huntington's disease. The study is designed as a multi-center single-blind randomised controlled intervention trial. Sixty patients will be randomised using centre-stratified block-permuted randomisation. Patients will be recruited from four long-term care facilities specialized in Huntington's disease-care in The Netherlands. The outcome measure to assess changes in expressive and communication skills is the Behaviour Observation Scale Huntington and changes in behavior will be assessed by the Problem Behaviour Assesment-short version and by the BOSH. Measurements take place at baseline, then 8, 16 (end of intervention) and 12 weeks after the last intervention (follow-up). This randomized controlled study will provide greater insight into the effectiveness of music therapy on activities of daily living, social-cognitive functioning and behavior problems by improving expressive and communication skills, thus leading to a better quality of life for patients with Huntington's disease. Netherlands Trial Register: NTR4904 , registration date Nov. 15, 2014.

  7. Characterisation of aggression in Huntington's disease: rates, types and antecedents in an inpatient rehabilitation setting.

    Science.gov (United States)

    Brown, Anahita; Sewell, Katherine; Fisher, Caroline A

    2017-10-01

    To systematically review aggression in an inpatient Huntington's cohort examining rates, types and antecedents. Although the prevalence of aggression in Huntington's disease is high, research into this problematic behaviour has been limited. Few studies have investigated the nature of aggressive behaviour in Huntington's disease or antecedents that contribute to its occurrence. A systematic, double-coded, electronic medical file audit. The electronic hospital medical records of 10 people with Huntington's disease admitted to a brain disorders unit were audited for a 90-day period using the Overt Aggression Scale-Modified for Neurorehabilitation framework, yielding 900 days of clinical data. Nine of 10 clients exhibited aggression during the audit period. Both verbal (37·1%) aggression and physical aggression were common (33·8%), along with episodes of mixed verbal and physical aggression (15·2%), while aggression to objects/furniture was less prevalent (5·5%). The most common antecedent was physical guidance with personal care, far exceeding any other documented antecedents, and acting as the most common trigger for four of the nine clients who exhibited aggression. For the remaining five clients, there was intraindividual heterogeneity in susceptibility to specific antecedents. In Huntington's sufferers at mid- to late stages following disease onset, particular care should be made with personal care assistance due to the propensity for these procedures to elicit an episode of aggression. However, given the degree of intraindividual heterogeneity in susceptibility to specific antecedents observed in the present study, individualised behaviour support plans and sensory modulation interventions may be the most useful in identifying triggers and managing aggressive episodes. Rates of aggression in Huntington's disease inpatients can be high. Knowledge of potential triggers, such as personal care, is important for nursing and care staff, so that attempts can be

  8. Visit of Professor Shigehiko Hasumi. President of Tokyo University, Japan, Professor Kazuo Okamoto, Head of Graduate School of Mathematical Sciences, Professor Toshiteru Matsuura, Head of Graduate School of Arts and Sciences

    CERN Multimedia

    Patrice Loiez

    1999-01-01

    Visit of Professor Shigehiko Hasumi. President of Tokyo University, Japan, Professor Kazuo Okamoto, Head of Graduate School of Mathematical Sciences, Professor Toshiteru Matsuura, Head of Graduate School of Arts and Sciences

  9. Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease

    DEFF Research Database (Denmark)

    Aziz, N A; Jurgens, C K; Landwehrmeyer, G B

    2009-01-01

    OBJECTIVE: Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion in the HD gene (HTT). We aimed to assess whether interaction between CAG repeat sizes in the mutant and normal allele could affect disease severity and progression. METHODS: Using...... with less severe symptoms and pathology. CONCLUSIONS: Increasing CAG repeat size in normal HTT diminishes the association between mutant CAG repeat size and disease severity and progression in Huntington disease. The underlying mechanism may involve interaction of the polyglutamine domains of normal...

  10. Mental Symptoms in Huntington's Disease and a Possible Primary Aminergic Neuron Lesion

    Science.gov (United States)

    Mann, J. John; Stanley, Michael; Gershon, Samuel; Rossor, M.

    1980-12-01

    Monoamine oxidase activity was higher in the cerebral cortex and basal ganglia of patients dying from Huntington's disease than in controls. Enzyme kinetics and multiple substrate studies indicated that the increased activity was due to elevated concentrations of monoamine oxidase type B. Concentrations of homovanillic acid were increased in the cerebral cortex but not in the basal ganglia of brains of patients with Huntington's disease. These changes may represent a primary aminergic lesion that could underlie some of the mental symptoms of this disease.

  11. REDES SOCIAIS E FORMAÇÃO DE PROFESSORES

    Directory of Open Access Journals (Sweden)

    Gilmara Teixeira Barcelos

    2012-09-01

    Full Text Available Os desafios estabelecidos pelas inovações tecnológicas ao processo educativo são muitos e diversas são as alternativas de práticas pedagógicas que envolvem o uso das mesmas. Nessa perspectiva, esta conferência visa a apresentar uma pesquisa que discute a prática pedagógica alicerçada nas tecnologias digitais (TD como instrumentos mediadores. Considerando que a formação de professores é um processo contínuo, foi elaborada uma proposta de formação, para os egressos da licenciatura em Matemática de um Instituto Federal, no início de sua prática docente . A proposta foi denominada T-PROIM – Tecnologias na Prática docente de pROfessores Iniciantes de Matemática. Uma rede social na Internet (RSI foi implementada por meio da plataforma Elgg para apoiar a referida formação. Essa visou a possibilitar a integração das TD à prática docente e fundamentou-se na teoria sócio-histórica. A pesquisa foi descritiva e explicativa, por meio de um estudo de caso e a abordagem foi, predominantemente, qualitativa. As técnicas de coleta de dados foram questionário, entrevistas, observação e registro dos conteúdos postados na RSI. Para tanto, inicialmente, caracterizam-se redes sociais na internet. A seguir, são apresentados os aspectos metodológicos, as características da formação T-PROIM e a análise macro da experimentação da referida formação. Finalizando, são tecidas algumas considerações sobre a pesquisa. A flexibilidade da formação e da configuração de recursos RSI foi considerada importante para o contexto educacional. Além disso, a análise possibilitou identificar que a confiança no uso pedagógico das TD aumentou e que a formação contribuiu para o desenvolvimento pessoal, social e cognitivo.

  12. O YouTube e o Cyberbullying de alunos contra professores around the world

    Directory of Open Access Journals (Sweden)

    Antonio Alvaro Soares Zuin

    2017-08-01

    , Portugal e Inglaterra, cujas imagens se referem a situações vivenciadas com seus respectivos professores. Pretende-se, ainda, argumentar que tais atitudes são indícios de transformações radicais que estão ocorrendo em relação ao modo como os alunos identificam o professor como uma autoridade pedagógica.

  13. Tremor in neurodegenerative ataxias, Huntington disease and tic disorder.

    Science.gov (United States)

    Rudzińska, M; Krawczyk, M; Wójcik-Pędziwiatr, M; Szczudlik, A; Tomaszewski, T

    2013-01-01

    Tremor is the most prevalent movement disorder, defined as rhythmic oscillations of a body part, caused by alternating or synchronic contractions of agonistic or antagonistic muscles. The aim of the study was to assess prevalence and to characterize parameters of tremor accompanying de-generative ataxias, Huntington disease (HD) and tic disorders in comparison with a control group. Forty-three patients with degenerative ataxias, 28 with HD and 26 with tic disorders together with 51 healthy controls were included in the study. For each participant, clinical and instrumental assessment (accelerometer, electromyography [EMG], graphic tablet) of hand tremor was performed. Frequency and severity of tremor were assessed in three positions: at rest (rest tremor), with hands extended (postural tremor), during the 'finger-to-nose' test and during Archimedes spiral drawing (kinetic tremor). Based on the mass load test, the type of tremor was determined as essential tremor type or enhanced physiological tremor type. The incidence of tremor in the accelerometry in patients with degenerative ataxia (50%) significantly differs from controls (10%) (p = 0.001). The dominant tremor was postural, low-intense, with 7-Hz frequency, essential tremor (23%) or other tremor type (23%), while enhanced physiological tremor was the least frequent (2%). Tremor in patients with HD and tic disorders was found in 10% and 20% of patients, respectively, similarly to the control group. Tremor was mild, postural and of essential tremor type, less frequently of enhanced physiological tremor type. No correlation between severity of tremor and severity of disease was found. The prevalence of tremor is considerably higher among patients with degenerative ataxias compared with HD, tic disorder and the control group. The most common type of tremor accompanying ataxias, HD and tic disorders is essential tremor type.

  14. Predictors of Workplace Disability in a Premanifest Huntington's Disease Cohort.

    Science.gov (United States)

    Goh, Anita M Y; You, Emily; Perin, Stephanie; Clay, Fiona J; Loi, Samantha; Ellis, Kathryn; Chong, Terence; Ames, David; Lautenschlager, Nicola

    2018-01-01

    Huntington's disease (HD) is an inherited neurodegenerative disease involving motor, cognitive, and psychiatric/behavioral impairments that will eventually affect work role functioning. Few objective data exist regarding predictors of workplace disability in HD. The authors explored the predictors of work impairment and disability in a cross-sectional cohort of 656 employed, premanifest HD (preHD) individuals. In this cohort-the majority of whom were female, urban-dwelling, married/partnered, and working full-time, with minimal cognitive impairment, good function, minimal motor abnormality, and no indication of significant mental health issues-the number of participants who reported that they had missed work due to HD was low (2.4%). However, 12% of the study sample reported experiencing impairment while working due to preHD, 12.2% reported work-related activity impairment due to preHD, and 12.7% reported impairment in their overall work ability. Higher numbers of CAG repeats on the mutant allele and having more motor symptoms were associated with significantly higher odds of experiencing workplace impairment. Importantly, several modifiable factors were also found to predict workplace disability. Specifically, higher levels of anxiety symptoms were associated with significantly higher odds of experiencing workplace impairment. Good mental and physical health served as protective factors, where good physical health was associated with 6% lower odds of experiencing impairment or missing work time and good mental health was associated with of 10%-12% lower. The results provide important new knowledge for the development of future targeted intervention trials to support preHD individuals in maintaining their work roles as long as possible.

  15. Patterns of False Memory in Patients with Huntington's Disease.

    Science.gov (United States)

    Chen, I-Wen; Chen, Chiung-Mei; Wu, Yih-Ru; Hua, Mau-Sun

    2017-06-01

    Increased false memory recognition in patients with Huntington's disease (HD) has been widely reported; however, the underlying memory constructive processes remain unclear. The present study explored gist memory, item-specific memory, and monitoring ability in patients with HD. Twenty-five patients (including 13 patients with mild HD and 12 patients with moderate-to-severe HD) and 30 healthy comparison participants (HC) were recruited. We used the Deese-Roediger-McDermott (DRM) paradigm to investigate participants' false recognition patterns, along with neuropsychological tests to assess general cognitive function. Both mild and moderate-to-severe patients with HD showed significant executive functioning and episodic memory impairment. On the DRM tasks, both HD patient groups showed significantly impaired performance in tasks assessing unrelated false recognition and item-specific memory as compared to the HC group; moderate-to-severe patients performed more poorly than mild patients did. Only moderate-severe patients exhibited significantly poorer related false recognition index scores than HCs in the verbal DRM task; performance of HD patient groups was comparable to the HC group on the pictorial DRM task. It appears that diminished verbatim memory and monitoring ability are early signs of cognitive decline during the HD course. Conversely, gist memory is relatively robust, with only partial decline during advanced-stage HD. Our findings suggest that medial temporal lobe function is relatively preserved compared to that of frontal-related structures in early HD. Thus, gist-based memory rehabilitation programs might be beneficial for patients with HD. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. An electrophysiological analysis of altered cognitive functions in Huntington disease.

    Science.gov (United States)

    Münte, T F; Ridao-Alonso, M E; Preinfalk, J; Jung, A; Wieringa, B M; Matzke, M; Dengler, R; Johannes, S

    1997-09-01

    Neuropsychological deficits are a main feature of Huntington disease (HD) with previous data suggesting involvement of memory functions and visual processing. To increase the knowledge about cognitive malfunction in HD in the domains of visual processing and memory by the use of modern electrophysiological techniques (event-related potentials [ERPs]). A case-control design was used. Three ERP paradigms were used; a parallel visual search paradigm allowed for the simultaneous processing of a multi-element visual array in search of a target stimulus, while a serial search paradigm with varied numbers of distractor items necessitated a serial one by one scanning of the arrays. The third experiment was a word-recognition memory task. The measurements were obtained in a neurophysiological laboratory of a university hospital. Nine patients with HD and 9 control subjects matched for age, sex, and education were studied. Components of averaged ERPs were quantified by latency and amplitude measures and subjected to statistical analysis. Behavioral measures (search time, hit rate, and recognition accuracy) were assessed as well. The early visual components showed a significant latency shift (delay of about 50 milliseconds) in HD. In the search paradigms the P3 components differentiating target and standard stimuli were virtually absent in HD as was the ERP effect indexing word recognition. This was accompanied by a marked delay in search times and lower hit rates in the search tasks and a grossly reduced recognition accuracy in the memory task. The results suggest marked impairments of patients with HD in early visual sensory processing (early components). Deficits in visual search might be attributed to an impairment to deploy attentional resources across the visual field and/or an inability to control eye movements. The ERPs in the memory task differed grossly from similar data obtained by others in patients with Alzheimer disease, suggesting a different neural basis for

  17. Identification of extreme motor phenotypes in Huntington's disease.

    Science.gov (United States)

    Braisch, Ulrike; Hay, Birgit; Muche, Rainer; Rothenbacher, Dietrich; Landwehrmeyer, G Bernhard; Long, Jeffrey D; Orth, Michael

    2017-04-01

    The manifestation of motor signs in Huntington's disease (HD) has a well-known inverse relationship with HTT CAG repeat length, but the prediction is far from perfect. The probability of finding disease modifiers is enhanced in individuals with extreme HD phenotypes. We aimed to identify extreme HD motor phenotypes conditional on CAG and age, such as patients with very early or very late onset of motor manifestation. Retrospective data were available from 1,218 healthy controls and 9,743 HD participants with CAG repeats ≥40, and a total of about 30,000 visits. Boundaries (2.5% and 97.5% quantiles) for extreme motor phenotypes (UHDRS total motor score (TMS) and motor age-at-onset) were estimated using quantile regression for longitudinal data. More than 15% of HD participants had an extreme TMS phenotype for at least one visit. In contrast, only about 4% of participants were consistent TMS extremes at two or more visits. Data from healthy controls revealed an upper cut-off of 13 for the TMS representing the extreme of motor ratings for a normal aging population. In HD, boundaries of motor age-at-onset based on diagnostic confidence or derived from the TMS data cut-off in controls were similar. In summary, a UHDRS TMS of more than 13 in an individual carrying the HD mutation indicates a high likelihood of motor manifestations of HD irrespective of CAG repeat length or age. The identification of motor phenotype extremes can be useful in the search for disease modifiers, for example, genetic or environmental such as medication. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. Drosophila eye color mutants as therapeutic tools for Huntington disease.

    Science.gov (United States)

    Green, Edward W; Campesan, Susanna; Breda, Carlo; Sathyasaikumar, Korrapati V; Muchowski, Paul J; Schwarcz, Robert; Kyriacou, Charalambos P; Giorgini, Flaviano

    2012-01-01

    Huntington disease (HD) is a fatal inherited neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein (htt). A pathological hallmark of the disease is the loss of a specific population of striatal neurons, and considerable attention has been paid to the role of the kynurenine pathway (KP) of tryptophan (TRP) degradation in this process. The KP contains three neuroactive metabolites: 3-hydroxykynurenine (3-HK), quinolinic acid (QUIN), and kynurenic acid (KYNA). 3-HK and QUIN are neurotoxic, and are increased in the brains of early stage HD patients, as well as in yeast and mouse models of HD. Conversely, KYNA is neuroprotective and has been shown to be decreased in HD patient brains. We recently used a Drosophila model of HD to measure the neuroprotective effect of genetic and pharmacological inhibition of kynurenine monoxygenase (KMO)-the enzyme catalyzing the formation of 3-HK at a pivotal branch point in the KP. We found that KMO inhibition in Drosophila robustly attenuated neurodegeneration, and that this neuroprotection was correlated with reduced levels of 3-HK relative to KYNA. Importantly, we showed that KP metabolites are causative in this process, as 3-HK and KYNA feeding experiments modulated neurodegeneration. We also found that genetic inhibition of the upstream KP enzyme tryptophan-2,3-dioxygenase (TDO) was neuroprotective in flies. Here, we extend these results by reporting that genetic impairment of KMO or TDO is protective against the eclosion defect in HD model fruit flies. Our results provide further support for the possibility of therapeutic KP interventions in HD.

  19. Brain imaging and cognitive dysfunctions in Huntington's disease

    Science.gov (United States)

    Montoya, Alonso; Price, Bruce H.; Menear, Matthew; Lepage, Martin

    2006-01-01

    Recent decades have seen tremendous growth in our understanding of the cognitive dysfunctions observed in Huntington's disease (HD). Advances in neuroimaging have contributed greatly to this growth. We reviewed the role that structural and functional neuroimaging techniques have played in elucidating the cerebral bases of the cognitive deficits associated with HD. We conducted a computer-based search using PubMed and PsycINFO databases to retrieve studies of patients with HD published between 1965 and December 2004 that reported measures on cognitive tasks and used neuroimaging techniques. Structural neuroimaging has provided important evidence of morphological brain changes in HD. Striatal and cortical atrophy are the most common findings, and they correlate with cognitive deficits in attention, working memory and executive functions. Functional studies have also demonstrated correlations between striatal dysfunction and cognitive performance. Striatal hypoperfusion and decreased glucose utilization correlate with executive dysfunction. Hypometabolism also occurs throughout the cerebral cortex and correlates with performance on recognition memory, language and perceptual tests. Measures of presynaptic and postsynaptic dopamine biochemistry have also correlated with measurements of episodic memory, speed of processing and executive functioning. Aided by the results of numerous neuroimaging studies, it is becoming increasingly clear that cognitive deficits in HD involve abnormal connectivity between the basal ganglia and cortical areas. In the future, neuroimaging techniques may shed the most light on the pathophysiology of HD by defining neurodegenerative disease phenotypes as a valuable tool for knowing when patients become “symptomatic,” having been in a gene-positive presymptomatic state, and as a biomarker in following the disease, thereby providing a prospect for improved patient care. PMID:16496032

  20. Progressive microstructural changes of the occipital cortex in Huntington's disease.

    Science.gov (United States)

    Odish, Omar F F; Reijntjes, Robert H A M; van den Bogaard, Simon J A; Roos, Raymund A C; Leemans, Alexander

    2018-02-28

    In this study we longitudinally investigated the rate of microstructural alterations in the occipital cortex in different stages of Huntington's disease (HD) by applying an automated atlas-based approach to diffusion MRI data. Twenty-two premanifest (preHD), 10 early manifest HD (early HD) and 24 healthy control subjects completed baseline and two year follow-up scans. The preHD group was stratified based on the predicted years to disease onset into a far (preHD-A) and near (preHD-B) to disease onset group. Clinical and behavioral measures were collected per assessment time point. An automated atlas-based DTI analysis approach was used to obtain the mean, axial and radial diffusivities of the occipital cortex. We found that the longitudinal rate of diffusivity change in the superior occipital gyrus (SOG), middle occipital gyrus (MOG), and inferior occipital gyrus (IOG) was significantly higher in early HD compared to both preHD and controls (all p's ≤ 0.005), which can be interpreted as an increased rate of microstructural degeneration. Furthermore, the change rate in the diffusivity of the MOG could significantly discriminate between preHD-B compared to preHD-A and the other groups (all p's ≤ 0.04). Finally, we found an inverse correlation between the Stroop Word Reading task and diffusivities in the SOG and MOG (all p's ≤ 0.01). These findings suggest that measures obtained from the occipital cortex can serve as sensitive longitudinal biomarkers for disease progression in preHD-B and early HD. These could in turn be used to assess potential effects of proposed disease modifying therapies.

  1. Late-onset Huntington's disease: diagnostic and prognostic considerations.

    Science.gov (United States)

    Koutsis, Georgios; Karadima, Georgia; Kladi, Athina; Panas, Marios

    2014-07-01

    To address diagnostic and prognostic issues in patients with late-onset Huntington's disease (HD). We analyzed a cohort of 41 late-onset (≥60 years) HD patients and compared them to 39 late-onset patients referred for HD testing that were negative for the HD-expansion and to 290 usual-onset (20-59 years) HD patients. Disease severity was assessed by the Total Functional Capacity Scale. Late-onset HD comprised 11.5% of our HD cohort. In total, 70.7% of late-onset HD patients had positive family history compared to 15.4% of late-onset expansion-negative patients (p < 0.001). Clinical features at onset or presentation could not usefully distinguish between late-onset expansion-positive and negative patients, excepting hemichorea, which was absent from the HD group (p = 0.024). Chorea was the first clinical feature in 53.7% and a presenting feature in 90.2% of late-onset HD. The mutation hit rate for late-onset patients was 51.3%, lower than in usual-onset patients (p = 0.04). Frequencies of chorea, cognitive impairment and psychiatric manifestations at onset or presentation were not significantly different between late-onset and usual-onset HD patients. Gait unsteadiness however was more common at presentation in late-onset HD (p = 0.007). Late-onset HD patients reached a severe stage of illness on average 2.8 years earlier than usual-onset HD patients (p = 0.046). A positive family history suggestive of HD, although absent in a third of patients, remains a helpful clue in diagnosing late-onset HD. Prognosis of late-onset HD in terms of Total Functional Capacity appears no better and shows a trend of being somewhat less favorable compared to usual-onset HD. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Redox Pioneer: Professor Vadim N. Gladyshev.

    Science.gov (United States)

    Hatfield, Dolph L

    2016-07-01

    Professor Vadim N. Gladyshev is recognized here as a Redox Pioneer, because he has published an article on antioxidant/redox biology that has been cited more than 1000 times and 29 articles that have been cited more than 100 times. Gladyshev is world renowned for his characterization of the human selenoproteome encoded by 25 genes, identification of the majority of known selenoprotein genes in the three domains of life, and discoveries related to thiol oxidoreductases and mechanisms of redox control. Gladyshev's first faculty position was in the Department of Biochemistry, the University of Nebraska. There, he was a Charles Bessey Professor and Director of the Redox Biology Center. He then moved to the Department of Medicine at Brigham and Women's Hospital, Harvard Medical School, where he is Professor of Medicine and Director of the Center for Redox Medicine. His discoveries in redox biology relate to selenoenzymes, such as methionine sulfoxide reductases and thioredoxin reductases, and various thiol oxidoreductases. He is responsible for the genome-wide identification of catalytic redox-active cysteines and for advancing our understanding of the general use of cysteines by proteins. In addition, Gladyshev has characterized hydrogen peroxide metabolism and signaling and regulation of protein function by methionine-R-sulfoxidation. He has also made important contributions in the areas of aging and lifespan control and pioneered applications of comparative genomics in redox biology, selenium biology, and aging. Gladyshev's discoveries have had a profound impact on redox biology and the role of redox control in health and disease. He is a true Redox Pioneer. Antioxid. Redox Signal. 25, 1-9.

  3. Podcasts: características nas produções de professores em formação continuada

    Directory of Open Access Journals (Sweden)

    Vera Lúcia Lopes Cristovão

    2014-03-01

    Full Text Available A globalização proporcionou uma extensa variedade de ferramentas tecnológicas que podem ser parte do processo de ensino / aprendizagem de uma língua estrangeira, entre elas, a mídia em foco neste trabalho, os podcasts. Pesquisas recentes têm celebrado essa mídia como um excelente recurso para professores com o objetivo supracitado (MEDEIROS, 2006; SOUZA; MARTINS,2007; UCHOA, 2010. Neste trabalho, que faz parte de um projeto maior intitulado “O uso de podcasts na educação continuada de professores de línguainglesa”, apresentamos a análise dos podcasts produzidos por professores em formação continuada durante um curso projetado para dar suporte aos professores com algumas ferramentas tecnológicas digitais emergentes. Em primeiro lugar, apresentamos nosso referencial teórico-metodológico, baseado principalmente no Interacionismo Sociodiscursivo (ISD. Em seguida, trazemos a discussão dos resultados, que aponta que o ensino com base em gêneros textuais proposto pelo ISD alcançou seu objetivo, o de preparar os professores para que possam utilizar a ferramenta podcast com propriedade e destreza. Os resultados também apontam que alguns dos professores ainda precisam melhorar suas habilidades de produção oral para trabalhar com mídias e gêneros textuais orais. Além disso, chegamos à conclusão de que o uso de tecnologias emergentes ainda precisa vencer algumas barreiras.

  4. O fracasso escolar no discurso do professor

    OpenAIRE

    Piccirilli, Manoela de Souza Silva

    2014-01-01

    O fracasso escolar tem sido repetidamente abordado em pesquisas de diversas naturezas que buscam diferentes razões para sua ocorrência. Essa dissertação não pretende elaborar mais uma suposição do que venha a ser o fracasso escolar, mas analisar os sentidos deste no discurso de alguns professores de educação básica. Trata-se de um estudo qualitativo realizado sob a ótica da teoria-metodológica da Análise de Discurso de linha francesa a partir de Michel Pêcheux. O procedimento ...

  5. An Interview with Professor Roy Caldwell

    OpenAIRE

    Chowdhary, Kuntal; Bhat, Prashant; Rosen, Jared; Naughton, Ida; Wang, Jingyan

    2013-01-01

    Envision the underwater world: vibrant coral, swaying seaweed, and lively creatures abound. However, the postcards and National Geographic covers that try to capture the beauty of this picturesque habitat can only represent it at one moment in time -- in reality, the landscape is hardly static, since many of its animals are capable of body modifications to change their shape and color. To understand the coloration and color vision of sea creatures, UC Berkeley Professor Roy L. Caldwell resear...

  6. As representações como processo de significação do (futuro professor de Língua Portuguesa

    Directory of Open Access Journals (Sweden)

    Pollyanne Bicalho Ribeiro

    2011-07-01

    Full Text Available Propomos, neste artigo, uma discussão acerca da reconstituição identitária do professor de LP, visando analisar representações sobre o grupo professor e o trabalho que lhe é atribuído, bem como as consequências dessas representações para o processo de ensino/aprendizagem. A partir dos pressupostos do Interacionismo Sociodiscursivo (ISD, conjugados com a Teoria das Representações Sociais (TRS, discutiremos os efeitos dessas representações para a (reformulação do agir do professor de LP em sala de aula sob a avaliação do estagiário/futuro professor. O corpus é constituído de excertos retirados de relatórios produzidos por estagiários ao observarem aulas de professores da rede privada e pública do município de Fortaleza.Palavras-chave: Representações sociais. Identidade do professor de LP. Prática formativa.

  7. Laboratórios de Ensino de História: refletindo e construindo com os professores

    Directory of Open Access Journals (Sweden)

    Maiara Cemin Cagliari

    2015-07-01

    Full Text Available O presente artigo tem o intuito de apresentar a importância e as formas de abrangência dos Laboratórios de Ensino dos Cursos de História. Buscaremos problematizar a atuação desses espaços na formação e qualificação dos futuros professores da educação básica, demonstrando sua importância na troca de experiências de ensino e aprendizagem, promovendo o auxílio aos alunos em estágios obrigatórios de docência. Visa a discutir também a importância que as atividades práticas oferecidas pelos espaços de apoio ao ensino possuem na relação entre teoria e prática e sua importância para a formação dos professores historiadores. Por fim, propomos uma reflexão sobre a importância das estratégias elaboradas pelos laboratórios de ensino de História da Universidade Federal do Rio Grande do Sul – LHISTE e da Universidade de Caxias do Sul - NAEH para estimular novas abordagens no ensino de História. Palavras-chave Ensino; História; Laboratório; Estratégias; Professores

  8. Por uma didática clínica: a formação do professor de psicologia

    Directory of Open Access Journals (Sweden)

    Tânia Maria Baibich

    2003-06-01

    Full Text Available Este estudo trata da natureza e da qualidade da formação do professor de psicologia com a finalidade de subsidiar as mudanças na estrutura curricular do curso de Licenciatura em Psicologia, tendo como base uma pesquisa aplicada junto aos alunos formandos na qual se procurou investigar os atributos de um Bom Professor. Analisando os resultados da pesquisa e partindo da concepção de que a reflexão coletiva e permanente sobre o processo de ensino-aprendizagem permite aprimorar a vinculação do método didático ao método de pensamento, na medida em que desvela para os próprios atores do processo a epistemologia que subjaz a toda e qualquer ação educativa, este estudo conclui pela necessidade de uma “didática clínica” para a formação do Bom Professor de Psicologia. Palavras-chave: licenciatura em Psicologia; didática clínica; princípios do ensino de Psicologia.

  9. AoS28D, a proline-Xaa carboxypeptidase secreted by Aspergillus oryzae.

    Science.gov (United States)

    Salamin, Karine; Eugster, Philippe J; Jousson, Olivier; Waridel, Patrice; Grouzmann, Eric; Monod, Michel

    2017-05-01

    Prolyl peptidases of the MEROPS S28 family are of particular interest because they are key enzymes in the digestion of proline-rich peptides. A BLAST analysis of the Aspergillus oryzae genome revealed sequences coding for four proteases of the S28 family. Three of these proteases, AoS28A, AoS28B, and AoS28C, were previously characterized as acidic prolyl endopeptidases. The fourth protease, AoS28D, showed high sequence divergence with other S28 proteases and belongs to a phylogenetically distinct cluster together with orthologous proteases from other Aspergillus species. The objective of the present paper was to characterize AoS28D protease in terms of substrate specificity and activity. AoS28D produced by gene overexpression in A. oryzae and in Pichia pastoris was a 70-kDa glycoprotein with a 10-kDa sugar moiety. In contrast with other S28 proteases, AoS28D did not hydrolyze internal Pro-Xaa bonds of several tested peptides. Similarly, to human lysosomal Pro-Xaa carboxypeptidase, AoS28D demonstrated selectivity for cleaving C-terminal Pro-Xaa bonds which are resistant to carboxypeptidases of the S10 family concomitantly secreted by A. oryzae. Therefore, AoS28D could act in synergy with these enzymes during sequential degradation of a peptide from its C-terminus.

  10. JUNCTOPHILIN 3 (JPH3) EXPANSION MUTATIONS CAUSING HUNTINGTON DISEASE LIKE 2 (HDL2) ARE COMMON IN SOUTH AFRICAN PATIENTS WITH AFRICAN ANCESTRY AND A HUNTINGTON DISEASE PHENOTYPE

    Science.gov (United States)

    Krause, A; Mitchell, CL; Essop, F; Tager, S; Temlett, J; Stevanin, G; Ross, CA; Rudnicki, DD; Margolis, RL

    2015-01-01

    Huntington disease (HD) is a progressive autosomal dominant neurodegenerative disorder, characterized by abnormal movements, cognitive decline and psychiatric symptoms, caused by a CAG repeat expansion in the huntingtin (HTT) gene on chromosome 4p. A CAG/CTG repeat expansion in the junctophilin-3 (JPH3) gene on chromosome 16q24.2 causes a Huntington disease-like phenotype (HDL2). All patients to date with HDL2 have some African ancestry. The present study aimed to characterize the genetic basis of the Huntington disease phenotype in South Africans and to investigate the possible origin of the JPH3 mutation. In a sample of unrelated South African individuals referred for diagnostic HD testing, 62% (106/171) of white patients compared to only 36% (47/130) of black patients had an expansion in HTT. However, 15% (20/130) of black South African patients and no white patients (0/171) had an expansion in JPH3, confirming the diagnosis of Huntington disease like 2 (HDL2). Individuals with HDL2 share many clinical features with individuals with HD and are clinically indistinguishable in many cases, although the average age of onset and diagnosis in HDL2 is 5 years later than HD and individual clinical features may be more prominent. HDL2 mutations contribute significantly to the HD phenotype in South Africans with African ancestry. JPH3 haplotype studies in 31 families, mainly from South Africa and North America, provide evidence for a founder mutation and support a common African origin for all HDL2 patients. Molecular testing in individuals with an HD phenotype and African ancestry should include testing routinely for JPH3 mutations. PMID:26079385

  11. Combate ao niilismo e ao totalitarismo em Camus

    Directory of Open Access Journals (Sweden)

    Emanuel Ricardo Germano

    2013-05-01

    Full Text Available A partir de uma leitura da peça Calígula, elaborada entre 1941 e 1943, procurar-se-á contribuir na restituição das preocupações éticas, políticas e filosóficas em cena no teatro de Albert Camus, analisando o sentido de sua expressão teatral no contexto de dois combates,ao niilismo filosófico e ao totalitarismo político de seu tempo. Observaremos em Calígula um importante registro do amadurecimento das leituras de duas heranças filosóficas relevantes na formação intelectual de Camus, Nietzsche e Heráclito, à luz da experiência do totalitarismo, observando e ressaltando com isso a amplitude de seu intertexto filosófico e a importância do aporte ético e político de Camus como pensador multifacetado, engajado nos enfrentamentos históricos e solicitações críticas de seu tempo.

  12. In Memoriam: Professor Jan M. Hoem

    Directory of Open Access Journals (Sweden)

    James W. Vaupel

    2017-02-01

    Full Text Available Jan Hoem died on Saturday in Stockholm after a long illness. Jan became Director of the Max Planck Institute for Demographic Research (MPIDR in 1999; he and I jointly led the Institute for almost eight years. During this period he served as Editor of Demographic Research; he took on this responsibility shortly after the journal was launched and built the journal into a respected online source of cutting-edge analysis. Jan was a superb colleague, with very good judgment, a delightful sense of humor, and deep devotion to research quality. A pioneer of event history analysis, he understood the subtleties of the subject better than anyone else. Jan was born and educated in Norway and worked in Oslo before becoming Professor in Copenhagen and then Professor in Stockholm, where he established SUDA, a leading demographic research initiative. His dedication to high-quality, statistically sophisticated population research at SUDA and MPIDR as well as in the journal Demographic Research substantially advanced the discipline of demography. Jan was a warm and generous teacher, a loyal colleague, and a caring friend whom many people will long remember with gratitude and respect. James W. Vaupel Publisher, Demographic Research

  13. Interview: Interview with Professor Malcolm Rowland.

    Science.gov (United States)

    Rowland, Malcolm

    2010-03-01

    Malcolm Rowland is Professor Emeritus and former Dean of the School of Pharmacy and Pharmaceutical Sciences and a member and former director (1996-2000), of the Centre for Applied Pharmacokinetic Research, University of Manchester. He holds the positions of Adjunct Professor, School of Pharmacy, University of California, San Francisco; Member, Governing Board, EU Network of Excellence in Biosimulation; Founder member of NDA Partners; academic advisor to a Pharmaceutical initiative in prediction of human pharmacokinetics and Scientific Advisor to the EU Microdose AMS Partnership Program. He was President of the EU Federation for Pharmaceutical Sciences (1996-2000); Vice-President of the International Pharmaceutical Federation (2001-2009) and a Board Member of the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs, 2004-2008). He received his degree in Pharmacy and PhD at the University of London and was on faculty (School of Pharmacy, University of California San Francisco [1967-1975]) before taking up a professorship at Manchester. His main research interest is physiologically based pharmacokinetics and its application to drug discovery, development and use. He is author of over 300 scientific articles and co-author, with TN Tozer, of the textbooks Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications and Introduction to Pharmacokinetics and Pharmacodynamics. He was editor of the Journal of Pharmacokinetics and Pharmacodynamics (formerly Journal of Pharmacokinetics and Biopharmaceutics, 1973-2007) and, since 1977, has organized regular residential workshops in pharmacokinetics.

  14. Professor de Hevesy traces radioisotope history

    International Nuclear Information System (INIS)

    1965-01-01

    Professor George de Hevesy, who was a pioneer in the field of radioactive tracers, prepared this paper for the IAEA symposium on Radiochemical Methods of Analysis, held at Salzburg in October 1964. Professor de Hevesy was born in Budapest in 1885. He studied in Budapest, Berlin and Freiburg, and spent some years at Zurich when Einstein was there. In 1911 he went to Manchester to work with Rutherford and there witnessed some of the greatest discoveries in the history of physics. At the end of 1912 he visited the Vienna Institute for Radium Research, where he worked with Paneth, and in 1913 applied the method of labelled lead for the first time. After the first world war, he worked at the Institute for Theoretical Physics in Copenhagen; since 1943, his chief activities have been in Sweden. In 1923, with Coster, he discovered the element hafnium. He made notable discoveries on the mobility of ions, and isotope separation, and his work on radioisotope tracers, which has had important biological applications, won him the Nobel Prize for Chemistry in 1943

  15. Behavioral testing of minipigs transgenic for the Huntington gene-A three-year observational study

    Czech Academy of Sciences Publication Activity Database

    Schuldenzucker, V.; Schubert, R.; Muratori, L. M.; Freisfeld, F.; Rieke, L.; Matheis, T.; Schramke, S.; Motlík, Jan; Kemper, N.; Radespiel, U.; Reilmann, R.

    2017-01-01

    Roč. 12, č. 10 (2017), č. článku e0185970. E-ISSN 1932-6203 Institutional support: RVO:67985904 Keywords : Huntington´s disease * minipigs Subject RIV: EG - Zoology OBOR OECD: Behavioral sciences biology Impact factor: 2.806, year: 2016

  16. Motor, emotional and cognitive deficits in adult BACHD mice : A model for Huntington's disease

    NARCIS (Netherlands)

    Abada, Yah-se K.; Schreiber, Rudy; Ellenbroek, Bart

    2013-01-01

    Rationale: Huntington's disease (HD) is characterized by progressive motor dysfunction, emotional disturbances and cognitive deficits. It is a genetic disease caused by an elongation of the polyglutamine repeats in the huntingtin gene. Whereas HD is a complex disorder, previous studies in mice

  17. Vertraagde diagnose van de ziekte van Huntington in een psychiatrische setting

    NARCIS (Netherlands)

    Tak, L M; Sizoo, B; de Stegge, B M Aan; Adema, S; van Duijn, E; Kremer, B

    2017-01-01

    Huntington's disease (hd) is characterised by a triad of neuropsychiatric symptoms, motor disturbances and cognitive decline. If initial symptoms are of neuropsychiatric nature they maybe misinterpreted, which can lead to delayed diagnosis. Three examples of delayed hd diagnosis in a psychiatric

  18. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

    DEFF Research Database (Denmark)

    Lee, J-M; Ramos, E M; Lee, J-H

    2012-01-01

    Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG repeat allele has been reported also to influence age at onset, in interaction with the expanded allele. Due to profound...

  19. Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease

    NARCIS (Netherlands)

    van Oostrom, JCH; Maguire, RP; Verschuuren-Bemelmans, CC; van der Duin, LV; Pruim, J; Roos, RAC; Leenders, KL

    2005-01-01

    Among 27 preclinical carriers of the Huntington disease mutation (PMC), the authors found normal striatal values for MRI volumetry in 88% and for fluorodesoxyglucose PET metabolic index in 67%. Raclopride PET binding potential (RAC-BP) was decreased in 50% and correlated with increases in the

  20. Hypocretin and melanin-concentrating hormone in patients with Huntington disease.

    NARCIS (Netherlands)

    Aziz, A.; Fronczek, R.; Maat-Schieman, M.L.; Unmehopa, U.A.; Roelandse, F.W.; Overeem, S.; Duinen, S.G. van; Lammers, G.J.; Swaab, D.F.; Roos, R.A.C.

    2008-01-01

    To evaluate whether hypocretin-1 (orexin-A) and melanin-concentrating hormone (MCH) neurotransmission are affected in patients with Huntington disease (HD), we immunohistochemically stained hypocretin and MCH neurons and estimated their total numbers in the lateral hypothalamus of both HD patients

  1. Functional Compensation of Motor Function in Pre-Symptomatic Huntington's Disease

    Science.gov (United States)

    Kloppel, Stefan; Draganski, Bogdan; Siebner, Hartwig R.; Tabrizi, Sarah J.; Weiller, Cornelius; Frackowiak, Richard S. J.

    2009-01-01

    Involuntary choreiform movements are a clinical hallmark of Huntington's disease. Studies in clinically affected patients suggest a shift of motor activations to parietal cortices in response to progressive neurodegeneration. Here, we studied pre-symptomatic gene carriers to examine the compensatory mechanisms that underlie the phenomenon of…

  2. 4p16.3 haplotype modifying age at onset of Huntington disease

    DEFF Research Database (Denmark)

    Nørremølle, A; Budtz-Jørgensen, E; Fenger, K

    2009-01-01

    Huntington disease (HD) is caused by an expanded CAG repeat sequence in the HD gene. Although the age at onset is correlated to the CAG repeat length, this correlation only explains approximately half of the variation in onset age. Less variation between siblings indicates that the variation is, ...

  3. The use of stem cells in regenerative medicine for Parkinson's and Huntington's Diseases.

    Science.gov (United States)

    Lescaudron, L; Naveilhan, P; Neveu, I

    2012-01-01

    Cell transplantation has been proposed as a means of replacing specific cell populations lost through neurodegenerative processes such as that seen in Parkinson's or Huntington's diseases. Improvement of the clinical symptoms has been observed in a number of Parkinson and Huntington's patients transplanted with freshly isolated fetal brain tissue but such restorative approach is greatly hampered by logistic and ethical concerns relative to the use of fetal tissue, in addition to potential side effects that remain to be controlled. In this context, stem cells that are capable of self-renewal and can differentiate into neurons, have received a great deal of interest, as demonstrated by the numerous studies based on the transplantation of neural stem/progenitor cells, embryonic stem cells or mesenchymal stem cells into animal models of Parkinson's or Huntington's diseases. More recently, the induction of pluripotent stem cells from somatic adult cells has raised a new hope for the treatment of neurodegenerative diseases. In the present article, we review the main experimental approaches to assess the efficiency of cell-based therapy for Parkinson's or Huntington's diseases, and discuss the recent advances in using stem cells to replace lost dopaminergic mesencephalic or striatal neurons. Characteristics of the different stem cells are extensively examined with a special attention to their ability of producing neurotrophic or immunosuppressive factors, as these may provide a favourable environment for brain tissue repair and long-term survival of transplanted cells in the central nervous system. Thus, stem cell therapy can be a valuable tool in regenerative medicine.

  4. Selected CSF biomarkers indicate no evidence of early neuroinflammation in Huntington disease

    DEFF Research Database (Denmark)

    Vinther-Jensen, Tua; Börnsen, Lars Svend; Budtz-Jorgensen, Esben

    2016-01-01

    Objective: To investigate CSF biomarkers of neuroinflammation and neurodegeneration in Huntington disease (HD) gene-expansion carriers compared to controls and to investigate these biomarkers in association with clinical HD rating scales and disease burden score. Methods: We collected CSF from 32...

  5. Beautiful Science: The Public and Private History of Astronomy at the Huntington Library

    Science.gov (United States)

    Lewis, Daniel

    2009-05-01

    The history of astronomy has a long tradition within research libraries. The rare collections at the Huntington Library (encompassing American and British history from around 1000 CE to the present, in many different subject areas) are among the most heavily-used in the United States, The history of astronomy holdings are a cornerstone within the library's history of science holdings. This talk will present the two faces of the history of astronomy holdings at the Huntington Library. The first of these is the research end of operations: what the collections consist of, how the scholarly public uses the collections, and what the implications are for modern astronomical practice. The second element concerns the public exhibit face of the history of astronomy holdings at The Huntington. Of the 600,000 people who visit the Huntington each year, the majority visit public displays and rare book and manuscript exhibits. "Beautiful Science: Ideas That Changed the World” is a new permanent history of science exhibit. One quarter of the exhibit relates to the history of astronomy. Public exhibits require a particular kind of planning and bring a specific set of values to the history of astronomy. Public exhibits also have their own concerns, and this talk will cover a number of those issues as well as the research issues.

  6. 77 FR 22616 - Huntington Asset Advisors, Inc., et al.; Notice of Application

    Science.gov (United States)

    2012-04-16

    ...''), Huntington Strategy Shares (``Trust''), and SEI Investments Distribution Co. Summary of Application.... \\14\\ If Shares are listed on The NASDAQ Stock Market LLC (``Nasdaq'') or a similar electronic Listing... SECURITIES AND EXCHANGE COMMISSION [Investment Company Act Release No. 30032; 812-13785...

  7. 77 FR 51064 - Huntington Foam LLC, Fort Smith, AR; Notice of Affirmative Determination Regarding Application...

    Science.gov (United States)

    2012-08-23

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-81,475] Huntington Foam LLC, Fort Smith, AR; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated May 21, 2012, the State Workforce Office requested administrative reconsideration of the negative...

  8. The use of olanzapine in Huntington disease accompanied by psychotic symptoms

    Directory of Open Access Journals (Sweden)

    Cafer Alhan

    2014-06-01

    Full Text Available Huntington's disease is an autosomal dominant neurodegenerative disease. The disease begins between the ages of 30-50, including motor symptoms, psychiatric symptoms and is characterized by progressive dementia. Common psychiatric disorders of Huntington’s disease include mood and anxiety disorders, behavior and personality changes. Psychosis is relatively rare. Here, a patient is present, who has Huntington’s disease, which is associated with psychotic symptoms. 61-year-old male patient who were followed for Huntington disease for 25 years was admitted for complaints of thinking of poisoning and refuse to eat something. Patient was started on olanzapine at dose of 5 mg/day. In follow up psychotic symptoms disappeared. Emerging psychotic symptoms in Huntington disease is created a need for antipsychotic treatment. Atypical antipsychotic agents should be preferred in the treatment and as in the case olanzapine may be used as a treatment option should be kept in mind to control both involuntary movements and psychotic symptoms in Huntington's disease with psychotic features. J Clin Exp Invest 2014; 5 (2: 326-328

  9. 3-NP-induced neurodegeneration studies in experimental models of Huntington's disease.

    NARCIS (Netherlands)

    Vis, J.C.

    2005-01-01

    This thesis investigates the possible role of apoptosis, or programmed cell death, in Huntington's disease (HD). HD is caused by an expanded CAG repeat in the N-terminal region of the huntingtin protein leading to specific neostriatal neurodegeneration. The sequence of events that leads to this

  10. Evidence for Deficits on Different Components of Theory of Mind in Huntington's Disease

    NARCIS (Netherlands)

    Allain, P.; Havel-Thomassin, V.; Verny, C.; Gohier, B.; Lancelot, C.; Besnard, J.; Fasotti, L.; Le Gall, D.

    2011-01-01

    Objective: The main aim of this study was to investigate the effects of Huntington's disease (HD) on cognitive and affective Theory of Mind (ToM) abilities. The relation of ToM performance and executive functions was also examined. Method: Eighteen HD patients, early in the course of the disease,

  11. A new mutation for Huntington disease following maternal transmission of an intermediate allele

    NARCIS (Netherlands)

    Semaka, Alicia; Kay, Chris; Belfroid, René D. M.; Bijlsma, Emilia K.; Losekoot, Monique; van Langen, Irene M.; van Maarle, Merel C.; Oosterloo, Mayke; Hayden, Michael R.; van Belzen, Martine J.

    2015-01-01

    New mutations for Huntington disease (HD) originate from CAG repeat expansion of intermediate alleles (27-35 CAG). Expansions of such alleles into the pathological range (≥ 36 CAG) have been exclusively observed in paternal transmission. We report the occurrence of a new mutation that defies the

  12. 75 FR 11939 - Fisher & Paykel Appliances, Inc., Huntington Beach, CA; Notice of Termination of Investigation

    Science.gov (United States)

    2010-03-12

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-71,749] Fisher & Paykel Appliances, Inc., Huntington Beach, CA; Notice of Termination of Investigation Pursuant to Section 221 of the Trade Act of 1974, as amended, an investigation was initiated in response to a petition filed on July 21...

  13. Reversal learning and associative memory impairments in a BACHD rat model for Huntington disease

    NARCIS (Netherlands)

    Abada, Yah-se K.; Nguyen, Huu Phuc; Ellenbroek, Bart; Schreiber, Rudy

    2013-01-01

    Chorea and psychiatric symptoms are hallmarks of Huntington disease (HD), a neurodegenerative disorder, genetically characterized by the presence of expanded CAG repeats (>35) in the HUNTINGTIN (HTT) gene. HD patients present psychiatric symptoms prior to the onset of motor symptoms and we recently

  14. Motor cortex synchronization influences the rhythm of motor performance in premanifest huntington's disease.

    Science.gov (United States)

    Casula, Elias P; Mayer, Isabella M S; Desikan, Mahalekshmi; Tabrizi, Sarah J; Rothwell, John C; Orth, Michael

    2018-03-01

    In Huntington's disease there is evidence of structural damage in the motor system, but it is still unclear how to link this to the behavioral disorder of movement. One feature of choreic movement is variable timing and coordination between sequences of actions. We postulate this results from desynchronization of neural activity in cortical motor areas. The objective of this study was to explore the ability to synchronize activity in a motor network using transcranial magnetic stimulation and to relate this to timing of motor performance. We examined synchronization in oscillatory activity of cortical motor areas in response to an external input produced by a pulse of transcranial magnetic stimulation. We combined this with EEG to compare the response of 16 presymptomatic Huntington's disease participants with 16 age-matched healthy volunteers to test whether the strength of synchronization relates to the variability of motor performance at the following 2 tasks: a grip force task and a speeded-tapping task. Phase synchronization in response to M1 stimulation was lower in Huntington's disease than healthy volunteers (P synchronization (r = -0.356; P synchronization and desynchronization could be a physiological basis for some key clinical features of Huntington's disease. © 2018 International Parkinson and Movement Disorder Society. © 2018 International Parkinson and Movement Disorder Society.

  15. Dificuldade visual em escolares: conhecimentos e ações de professores do ensino fundamental que atuam com alunos que apresentam visão subnormal

    Directory of Open Access Journals (Sweden)

    Gasparetto Maria Elisabete R. Freire

    2004-01-01

    Full Text Available OBJETIVOS: 1 Verificar os conhecimentos e ações desenvolvidas por professores do ensino fundamental, que atuam com alunos que apresentam visão subnormal, em relação aos sinais e sintomas indicativos de dificuldades visuais dos alunos; 2 Obter informações indispensáveis ao planejamento de ações preventivas direcionadas à saúde ocular na escola. MÉTODOS: Realizou-se levantamento entre professores do ensino fundamental de escolas públicas do município de Campinas/SP, que atuavam com alunos que apresentavam visão subnormal, no ano letivo de 1999. Foram incluídas 23 escolas onde se localizava essa população. Foi utilizado questionário auto-aplicável como instrumento de coleta de dados. RESULTADOS: De 84 professores, 68 (81% responderam ao questionário. A média de tempo de experiência profissional de magistério era de 20,8 anos. A maioria (92,6% não relatou formação na área da deficiência visual. Em relação ao conhecimento sobre os sinais e sintomas indicativos de dificuldade visual, a maioria indicou a dificuldade para ler na lousa (94,1%, seguida da cefal��ia (89,7% e a aproximação exagerada dos objetos aos olhos (88,2%. Desses professores, 55,9% identificaram alunos que apresentavam dificuldades visuais. Entre os que declararam ter identificado esses alunos, 84,2% proveram orientações ao escolar e 63,2% aos familiares para encaminhamento do problema. Somente 26,3% orientaram o aluno a procurar o oftalmologista. CONCLUSÃO: Os professores apresentaram conhecimento insuficiente quanto à saúde ocular e, portanto, as ações desenvolvidas não foram completas e abrangentes. Sugere-se a implantação de um programa de saúde ocular em todo o sistema público de ensino, visando desenvolver ações de prevenção da incapacidade visual, promoção e recuperação da saúde ocular.

  16. A ATUAÇÃO DE PROFESSORES DE ENSINO SUPERIOR: INVESTIGANDO DOIS PROFESSORES BEM AVALIADOS PELOS ESTUDANTES

    Directory of Open Access Journals (Sweden)

    Ana Luiza de Quadros

    2016-06-01

    Full Text Available In the last years, higher education teacher training has received more didactic-pedagogical attention. Despite numerous criticisms to professors' work, some practices present differentials that make them a reference to students, even among university professors with undergraduate and graduate degrees in their specific areas of knowledge. To analyze the classes of such professors who become a reference to students, we selected two higher education professors of chemistry and videotaped their classes seeking to identify the teaching strategies that they use. After analysis, we shared the results with the subjects and complemented them with a semi-structured interview. We found out that these professors perform based on counter-models of professors who they had had in their undergraduate courses and developed strategies aiming to minimize for their students the difficulties they themselves had experienced.

  17. An image-based model of brain volume biomarker changes in Huntington's disease.

    Science.gov (United States)

    Wijeratne, Peter A; Young, Alexandra L; Oxtoby, Neil P; Marinescu, Razvan V; Firth, Nicholas C; Johnson, Eileanoir B; Mohan, Amrita; Sampaio, Cristina; Scahill, Rachael I; Tabrizi, Sarah J; Alexander, Daniel C

    2018-05-01

    Determining the sequence in which Huntington's disease biomarkers become abnormal can provide important insights into the disease progression and a quantitative tool for patient stratification. Here, we construct and present a uniquely fine-grained model of temporal progression of Huntington's disease from premanifest through to manifest stages. We employ a probabilistic event-based model to determine the sequence of appearance of atrophy in brain volumes, learned from structural MRI in the Track-HD study, as well as to estimate the uncertainty in the ordering. We use longitudinal and phenotypic data to demonstrate the utility of the patient staging system that the resulting model provides. The model recovers the following order of detectable changes in brain region volumes: putamen, caudate, pallidum, insula white matter, nonventricular cerebrospinal fluid, amygdala, optic chiasm, third ventricle, posterior insula, and basal forebrain. This ordering is mostly preserved even under cross-validation of the uncertainty in the event sequence. Longitudinal analysis performed using 6 years of follow-up data from baseline confirms efficacy of the model, as subjects consistently move to later stages with time, and significant correlations are observed between the estimated stages and nonimaging phenotypic markers. We used a data-driven method to provide new insight into Huntington's disease progression as well as new power to stage and predict conversion. Our results highlight the potential of disease progression models, such as the event-based model, to provide new insight into Huntington's disease progression and to support fine-grained patient stratification for future precision medicine in Huntington's disease.

  18. Dantrolene is neuroprotective in Huntington's disease transgenic mouse model

    Directory of Open Access Journals (Sweden)

    Chen Xi

    2011-11-01

    Full Text Available Abstract Background Huntington's disease (HD is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs. Our group has previously demonstrated that calcium (Ca2+ signaling is abnormal in MSNs from the yeast artificial chromosome transgenic mouse model of HD (YAC128. Moreover, we demonstrated that deranged intracellular Ca2+ signaling sensitizes YAC128 MSNs to glutamate-induced excitotoxicity when compared to wild type (WT MSNs. In previous studies we also observed abnormal neuronal Ca2+ signaling in neurons from spinocerebellar ataxia 2 (SCA2 and spinocerebellar ataxia 3 (SCA3 mouse models and demonstrated that treatment with dantrolene, a ryanodine receptor antagonist and clinically relevant Ca2+ signaling stabilizer, was neuroprotective in experiments with these mouse models. The aim of the current study was to evaluate potential beneficial effects of dantrolene in experiments with YAC128 HD mouse model. Results The application of caffeine and glutamate resulted in increased Ca2+ release from intracellular stores in YAC128 MSN cultures when compared to WT MSN cultures. Pre-treatment with dantrolene protected YAC128 MSNs from glutamate excitotoxicty, with an effective concentration of 100 nM and above. Feeding dantrolene (5 mg/kg twice a week to YAC128 mice between 2 months and 11.5 months of age resulted in significantly improved performance in the beam-walking and gait-walking assays. Neuropathological analysis revealed that long-term dantrolene feeding to YAC128 mice significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates. Conclusions Our results support the hypothesis that deranged Ca2+ signaling plays an important role in HD pathology. Our data also implicate the RyanRs as a potential therapeutic target for the treatment of HD and demonstrate that Ryan

  19. Dantrolene is neuroprotective in Huntington's disease transgenic mouse model.

    Science.gov (United States)

    Chen, Xi; Wu, Jun; Lvovskaya, Svetlana; Herndon, Emily; Supnet, Charlene; Bezprozvanny, Ilya

    2011-11-25

    Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine expansion in the Huntingtin protein which results in the selective degeneration of striatal medium spiny neurons (MSNs). Our group has previously demonstrated that calcium (Ca2+) signaling is abnormal in MSNs from the yeast artificial chromosome transgenic mouse model of HD (YAC128). Moreover, we demonstrated that deranged intracellular Ca2+ signaling sensitizes YAC128 MSNs to glutamate-induced excitotoxicity when compared to wild type (WT) MSNs. In previous studies we also observed abnormal neuronal Ca2+ signaling in neurons from spinocerebellar ataxia 2 (SCA2) and spinocerebellar ataxia 3 (SCA3) mouse models and demonstrated that treatment with dantrolene, a ryanodine receptor antagonist and clinically relevant Ca2+ signaling stabilizer, was neuroprotective in experiments with these mouse models. The aim of the current study was to evaluate potential beneficial effects of dantrolene in experiments with YAC128 HD mouse model. The application of caffeine and glutamate resulted in increased Ca2+ release from intracellular stores in YAC128 MSN cultures when compared to WT MSN cultures. Pre-treatment with dantrolene protected YAC128 MSNs from glutamate excitotoxicty, with an effective concentration of 100 nM and above. Feeding dantrolene (5 mg/kg) twice a week to YAC128 mice between 2 months and 11.5 months of age resulted in significantly improved performance in the beam-walking and gait-walking assays. Neuropathological analysis revealed that long-term dantrolene feeding to YAC128 mice significantly reduced the loss of NeuN-positive striatal neurons and reduced formation of Httexp nuclear aggregates. Our results support the hypothesis that deranged Ca2+ signaling plays an important role in HD pathology. Our data also implicate the RyanRs as a potential therapeutic target for the treatment of HD and demonstrate that RyanR inhibitors and Ca2+ signaling stabilizers such as

  20. Obesidade infantil e bullying: a ótica dos professores Obesity in children and bullying: the teachers' viewpoint

    Directory of Open Access Journals (Sweden)

    Miguel Ataide Pinto da Costa

    2012-09-01

    Full Text Available Este estudo objetivou verificar a percepção de professores em relação aos problemas enfrentados por alunos obesos no ambiente escolar, bem como associar tais problemas à definição de bullying. Foram entrevistados 63 professores da rede estadual de um município da região metropolitana do Rio de Janeiro e a eles foi feita uma pergunta aberta referente aos problemas enfrentados pelos alunos acima do peso. Tal pergunta, propositalmente, não mencionava a palavra bullying. Os professores foram abordados pelo pesquisador principal nas escolas, em período destinado ao descanso ou durante momentos em que os alunos estivessem realizando atividades que não necessitassem da intervenção direta do professor. As respostas foram agrupadas em dezessete categorias e os resultados mostraram que, segundo os professores, o problema mais enfrentado pelos alunos acima do peso é o preconceito. Além disso, como problemas enfrentados por esses alunos, ainda foram apontadas a exclusão, a timidez e a baixa autoestima, dentre outros. Os resultados também mostraram atitudes negativas do professor com relação aos alunos, os quais algumas vezes foram descritos como apáticos, desanimados, cansados, lentos, distraídos, preguiçosos, indispostos etc.; esse dado indica a possibilidade de o próprio professor atuar como autor do bullying. Os resultados da pesquisa evidenciam que mais estudos devem ser desenvolvidos a fim de buscar melhor compreensão do papel do professor diante da discriminação de alunos acima do peso, mais especificamente do bullying, de forma a permitir maior aprofundamento no desenvolvimento de ações que visem promover a diversidade cultural nas escolas.The purpose of this study was to investigate the perception of teachers in regard of the problems faced obese students in the school, as well as to associate such problems with the definition of bullying. Sixty-three teachers from the public schools in a city belonging to the

  1. DESENVOLVIMENTOECONÔMICO E POLÍTICA INDUSTRIAL E TECNOLÓGICA: A VISÃO DO PROFESSOR FABIO ERBER

    Directory of Open Access Journals (Sweden)

    Dulce Monteiro Filha

    2017-08-01

    Full Text Available RESUMO O texto ilustra o caminho teórico seguido pelo Professor Fabio Erber na construção de sua formação acadêmica, mostrando as conclusões da tese que escreveu para obter o grau de Doutor em Economia na Universidade de Sussex , assim como, aquela que lhe propiciou o título de professor titular do Instituto de Economia da Universidade Federal do Rio de Janeiro. Este artigo apresenta, também, os estudos sobre Convenções que estava realizando no Pós-Doutorado na Université de Paris XIII. Erber era um profissional respeitado por ex-colegas, alunos e amigos brasileiros e estrangeiros (latino-americanos, franceses, ingleses, etc., tendo contribuído para o pensamento latino-americano no que diz respeito aos temas que estudou.

  2. Professor Gender, Age, and “Hotness” in Influencing College Students’ Generation and Interpretation of Professor Ratings

    Directory of Open Access Journals (Sweden)

    Sara L. Sohr-Preston

    2016-09-01

    Full Text Available Undergraduate psychology students rated expectations of a bogus professor (randomly designated a man or woman and hot versus not hot based on an online rating and sample comments as found on RateMyProfessors.com (RMP. Five professor qualities were derived using principal components analysis (PCA: dedication, attractiveness, enhancement, fairness, and clarity. Participants rated current psychology professors on the same qualities. Current professors were divided based on gender (man or woman, age (under 35 or 35 and older, and attractiveness (at or below the median or above the median. Using multivariate analysis of covariance (MANCOVA, students expected hot professors to be more attractive but lower in clarity. They rated current professors as lowest in clarity when a man and 35 or older. Current professors were rated significantly lower in dedication, enhancement, fairness, and clarity when rated at or below the median on attractiveness. Results, with previous research, suggest numerous factors, largely out of professors’ control, influencing how students interpret and create professor ratings. Caution is therefore warranted in using online ratings to select courses or make hiring and promotion decisions. 

  3. Professor Howard Mason and oxygen activation

    International Nuclear Information System (INIS)

    Waterman, Michael R.

    2005-01-01

    Our understanding of the classification, function, mechanism, and structure of the enzymes which incorporate atoms of oxygen from atmospheric molecular oxygen during catalysis is based on the thoughtful and technically challenging experiments of two giants in the field of Biochemistry, Howard Mason and Osamu Hayaishi. This volume celebrates the 50th anniversary of the discovery and characterization of these 'oxygenase' enzymes and provides a broad view of how far this area of research has advanced. Professor Hayaishi describes herein his perspective on the background and major discoveries which led to the development of this field. Regrettably Howard Mason passed away at age 88 in 2003. I am indeed fortunate to have been a Ph.D. student with Howard and to have the opportunity to briefly review his role in the development of this field for this special commemorative issue of BBRC

  4. Institutional Support for the Virtual Professor

    Directory of Open Access Journals (Sweden)

    Tom JONES

    2004-01-01

    Full Text Available Academics who hold positions at single-mode, distance education institutions are presently being hampered by an adherence to a long-standing set of protocols (specific office location, face-to-face meetings that were put in place when the conventional post-secondary was the norm. With the advent of a powerful merging of personal computers and the internet, a shift from those protocols to one of support for the virtual professor is in the offing, to the benefit of both the professoriate and the student. A key factor in this shift is the degree and quality of institutional support that will allow these changes to take place. This paper focuses on a number of the key factors that will have to be addressed if this new type of distance education academic is to function effectively.

  5. Interview with Professor Dr. Daniel Spreng

    International Nuclear Information System (INIS)

    Nagel, C.; Kilchmann, A.

    2004-01-01

    This interview with Professor Dr. Daniel Spreng of the Center for Energy Policy and Economics (CEPE) in Zuerich, Switzerland, deals with questions concerning research in the area of energy economics. In particular, the situation in Switzerland, where mains-connected sources of energy such as electricity and gas play an important role in energy supply, is looked at in the light of market liberalisation. Various approaches to the liberalisation of gas and electricity systems are discussed and the costs of liberalised supply systems are compared with those of the present monopolistic situation. Also, energy reserves and the use of the gas distribution system in a future hydrogen-based energy supply scenario are looked at. Projects currently being worked on at the CEPE are reviewed

  6. Representações sociais dos professores no ensino-aprendizagem do adolescente com Síndrome de Down

    Directory of Open Access Journals (Sweden)

    Sandra Conceição Maria Vieira

    2015-12-01

    Full Text Available ResumoEste artigo tem por objetivo compreender e analisar as representações sociais dos professores sobre o processo ensino aprendizagem do adolescente com síndrome de Down. Adotou uma abordagem qualitativa, utilizando o conceito das representações sociais. A escola escolhida é regular e adepta a educação inclusiva. A coleta de dados foi realizada por meio de um questionário. As entrevistas foram transcritas na íntegra e submetidos à análise do discurso.Três professores participaram da pesquisa. Percebeu- se que esses professores ainda não sabem bem o que fazem dentro de sala de aula, porque nenhum deles conseguiram responder, de fato, como trabalham pedagogicamente com esses alunos com Síndrome de Down. Pode- se acreditar que os aspectos indicativos de Representações sociais foram amplas. A representação mostrou- se como desafiadora para maior parte dos professores entrevistados, visto que compreendem que é necessário realizar o processo de inclusão, porém muitas vezes não sabem como. Ainda existe uma concepção que o aluno não aprende, demonstrando uma representação excludente, em relação ao fato de excluí-lo do direito adquirir conhecimentos como qualquer outro aluno e ao fato da falta de meios pedagógicos que facilitariam o processo ensino aprendizagem dos mesmos. 

  7. Como responder ao momento presente?

    Directory of Open Access Journals (Sweden)

    Maria Filomena Molder

    2013-12-01

    Full Text Available http://dx.doi.org/10.5007/1984-784X.2013v13n19p13 Foi com esta pergunta — já um efeito de um primeiro encontro entre Irene Pimentel e eu própria — que decidimos desafiar colegas, estudantes e funci­onários da nossa Faculdade, FCSH (Faculdade de Ciências Sociais e Huma­nas, de outras Faculdades da Universidade Nova de Lisboa, de outras Uni­versidades e todos os interessados em con­siderar e discutir em comum aquilo que se passava em Portugal e que no anúncio da Jornada de 6 de De­zembro de 2012 se descrevia como um “processo de desmantela­mento social, económico e cultural sem precedentes — pese embora tantas compara­ções, baseadas na premissa da ‘eterna repetição’ — e cujas consequências não param de exceder as previsões dos responsáveis por esse desmantelamento”. Acedendo com todo o empenho e gratidão ao convite que me foi dirigido por Humberto Brito para fazer uma resenha da Jornada a publicar no primeiro número de Forma de Vida (saúdo a revista e o título, decidi-me, no entanto, a pôr de lado a resenha, que sob a forma de “Editorial” será em breve publi­cada no blogue Responder ao Momento Presente, entre­tanto criado, conjuntamente com os textos escritos pelos nossos convidados, com as parti­cipações de pessoas que corresponderam ao nosso apelo e ainda com contri­bui­ções que se alargaram para lá da Jornada; a que se juntará uma gravação em video, também disponível no Youtube.   Texto publicado originalmente em Forma de Vida, Lisboa, n.1, fev. 2013. Agrade­cemos à autora por permitir a republicação neste número do Boletim. [N.E.

  8. A formação de professores para a educação inclusiva: alguns aspectos de um trabalho colaborativo entre pesquisadores e professores da educação infantil

    Directory of Open Access Journals (Sweden)

    Rosane Michelli de Castro

    2011-12-01

    Full Text Available A fim de contribuir com a formação de professores da Educação Infantil para a Educação Inclusiva, neste artigo, tivemos como objetivo central descrever o modo como foi abordada a questão das dificuldades de aprendizagem e o impacto de um diagnóstico equivocado atribuído a uma criança em fase inicial de aprendizagem formal da escrita, em um dos encontros teórico-reflexivos empreendidosjunto a 43 professores de classes de Pré II, de dez escolas municipais de Educação Infantil, de um município do interior do Estado de São Paulo. Tal descrição foi norteada pelas etapas da abordagem colaborativa consideradas no subprojeto “Compreensão acerca do diagnóstico clínico da Dislexia e seu impacto no futuro escolar da criança matriculada em classes de Pré II da Educação Infantil”, desenvolvido como uma das etapas do projeto maior denominado “Despatologização da aprendizagem da escrita e Educação Inclusiva: reflexões e ações do professor de Educação Infantil”. Ao final, foi possível a identificação,mediante os relatos dos professores mencionados, da necessidade de ressignificação de suas vivências e experiências didáticas para a sistematização de novas ações direcionadas ao enfrentamento das dificuldades de aprendizagem que perpassam o processo de apropriação da escrita de parte dos alunos, o que poderá contribuir para a despatologização do ambiente escolar, na medida em que os professores poderão auxiliar seus alunos na construção deuma relação mais positiva com a escrita, em detrimento da adoção de procedimentos rígidos e restritos que não consideram a relação de cada sujeito com a escrita e as singularidades presentes em tal relação. Palavras-chave: Educação; Formação de professores; Educação Inclusiva.

  9. Striatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's disease.

    Directory of Open Access Journals (Sweden)

    Stéphanie Bissonnette

    Full Text Available The reduction of pre-enkephalin (pENK mRNA expression might be an early sign of striatal neuronal dysfunction in Huntington's disease (HD, due to mutated huntingtin protein. Indeed, striatopallidal (pENK-containing neurodegeneration occurs at earlier stage of the disease, compare to the loss of striatonigral neurons. However, no data are available about the functional role of striatal pENK in HD. According to the neuroprotective properties of opioids that have been recognized recently, the objective of this study was to investigate whether striatal overexpression of pENK at early stage of HD can improve motor dysfunction, and/or reduce striatal neuronal loss in the R6/2 transgenic mouse model of HD. To achieve this goal recombinant adeno-associated-virus (rAAV2-containing green fluorescence protein (GFP-pENK was injected bilaterally in the striatum of R6/2 mice at 5 weeks old to overexpress opioid peptide pENK. Striatal injection of rAAV2-GFP was used as a control. Different behavioral tests were carried out before and/or after striatal injections of rAAV2. The animals were euthanized at 10 weeks old. Our results demonstrate that striatal overexpression of pENK had beneficial effects on behavioral symptoms of HD in R6/2 by: delaying the onset of decline in muscular force; reduction of clasping; improvement of fast motor activity, short-term memory and recognition; as well as normalization of anxiety-like behavior. The improvement of behavioral dysfunction in R6/2 mice having received rAAV2-GFP-pENK associated with upregulation of striatal pENK mRNA; the increased level of enkephalin peptide in the striatum, globus pallidus and substantia nigra; as well as the slight increase in the number of striatal neurons compared with other groups of R6/2. Accordingly, we suggest that at early stage of HD upregulation of striatal enkephalin might play a key role at attenuating illness symptoms.

  10. Aerosol Observing System (AOS) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Jefferson, A

    2011-01-17

    The Aerosol Observing System (AOS) is a suite of in situ surface measurements of aerosol optical and cloud-forming properties. The instruments measure aerosol properties that influence the earth’s radiative balance. The primary optical measurements are those of the aerosol scattering and absorption coefficients as a function of particle size and radiation wavelength and cloud condensation nuclei (CCN) measurements as a function of percent supersaturation. Additional measurements include those of the particle number concentration and scattering hygroscopic growth. Aerosol optical measurements are useful for calculating parameters used in radiative forcing calculations such as the aerosol single-scattering albedo, asymmetry parameter, mass scattering efficiency, and hygroscopic growth. CCN measurements are important in cloud microphysical models to predict droplet formation.

  11. The Limited Role of Journalism Professors in Direct Media Criticism.

    Science.gov (United States)

    Bass, Abraham Z.

    This paper discusses reasons why few journalism professors are personally confronting the news media with criticism or praise. One of the primary reasons for this is that journalism professors may fear retribution or keep inbred ties with the media or be following academic tradition. A survey was conducted in Spring 1975 for this report. The…

  12. Student and Professor Gender Effects in Introductory Business Statistics

    Science.gov (United States)

    Haley, M. Ryan; Johnson, Marianne F.; Kuennen, Eric W.

    2007-01-01

    Studies have yielded highly mixed results as to differences in male and female student performance in statistics courses; the role that professors play in these differences is even less clear. In this paper, we consider the impact of professor and student gender on student performance in an introductory business statistics course taught by…

  13. Professor om kystsikring: Ingen universelle løsninger

    DEFF Research Database (Denmark)

    Arnbjerg-Nielsen, Karsten

    2017-01-01

    DEBAT: Der findes ikke universalløsninger mod stigende risiko for stormfloder, men løsninger skal findes, skriver Karsten Arnbjerg-Nielsen, professor ved DTU.......DEBAT: Der findes ikke universalløsninger mod stigende risiko for stormfloder, men løsninger skal findes, skriver Karsten Arnbjerg-Nielsen, professor ved DTU....

  14. Effects of Social Support on Professors' Work Stress

    Science.gov (United States)

    Moeller, Christin; Chung-Yan, Greg A.

    2013-01-01

    Purpose: The purpose of this paper is to examine how various types of workplace social support from different support sources interact with occupational stressors to predict the psychological well-being of university professors. Design/method/approach: A total of 99 full-time professors participated via an online or paper questionnaire. Findings:…

  15. The benefits of being economics professor A (rather than Z)

    NARCIS (Netherlands)

    van Praag, C.M.; van Praag, B.M.S.

    2008-01-01

    Alphabetical name ordering on multi-authored academic papers, which is the convention in economics and various other disciplines, is to the advantage of people whose last name initials are placed early in the alphabet. Professor A, who has been a first author more often than Professor Z, will have

  16. University Pedagogy for Assistant Professors at Aalborg University (Part 2)

    DEFF Research Database (Denmark)

    Kolmos, Anette; Krogh, Lone

    2003-01-01

    In issue 1-2003, Anette Kolmos and Lone Krogh reported on the two-semester study course " University Pedagogy for Assistant Professors at Aalborg University (DK)". Now, in part 2, they are adressing guidelines for supervison and advising of assistant professors in the university teacher education...

  17. Do Professors Have Customer-Based Brand Equity?

    Science.gov (United States)

    Jillapalli, Ravi K.; Jillapalli, Regina

    2014-01-01

    This research endeavors to understand whether certain professors have customer-based brand equity (CBBE) in the minds of students. Consequently, the purpose of this study is to conceptualize, develop, and empirically test a model of customer-based professor brand equity. Survey data gathered from 465 undergraduate business students were used to…

  18. University Curriculum Project--Professors Reflect on Impact.

    Science.gov (United States)

    Babbitt, Beatrice C.

    This paper describes the reflections of the university professors in eight colleges at the University of Nevada, Las Vegas, who were pioneers in integrating assistive technology and related content into their courses and who continue to provide leadership in curricular change. Professors from the colleges of fine and performing arts, business,…

  19. Engaging Undergraduates in Feminist Classrooms: An Exploration of Professors' Practices

    Science.gov (United States)

    Spencer, Leland G.

    2015-01-01

    This article reports the results of a feminist action research project that sought to ascertain professors' best practices for engaging undergraduates in feminist classrooms. In semi-structured interviews, professors recommended assigning readings from a variety of positionalities; creating a safe space for class discussion; relying on data to…

  20. What I Wish My Professors Had Told Me

    Science.gov (United States)

    Collins, Jennifer

    2016-01-01

    What do you wish your undergraduate professors told you before you ever set foot in a classroom? Jennifer Collins, one such professor who prepares pre-service teachers, has a list of six "truths" she shares with her students. In this article, Collins outlines those pieces of advice, which include understanding your larger purpose,…

  1. Mental Health Assessment in Professors' Training in Two Chilean Universities

    Science.gov (United States)

    Ossa, Carlos J.; Quintana, Ingrid M.; Rodriguez, Felipe F.

    2015-01-01

    This study analyzed the evaluation of professors of pedagogy and directors programs, about the importance of mental health in vocational training, and factors that might influence this valuation. The methodology includes participation of 17 academicians (professors and belonging to the managerial staff) of two universities in southern Chile. A…

  2. Academic Labor Markets and Assistant Professors' Employment Outcomes

    Science.gov (United States)

    Hargens, Lowell L.

    2012-01-01

    Using data for 638 assistant professors who joined graduate sociology departments between 1975 and 1992, I examine the claim that when the labor market for new doctorates is weak, assistant professors experience less favorable employment outcomes than when that labor market is strong. Surprisingly, I find that those hired during the weak…

  3. Fatores de risco e emocionais na voz de professores com e sem queixas vocais

    Directory of Open Access Journals (Sweden)

    Denise Batista da Costa

    2013-08-01

    Full Text Available OBJETIVO: analisar a interferência dos fatores de riscos e emocionais na voz de professores com e sem queixa. MÉTODO: a amostra foi composta de 44 professores. Utilizou-se uma ficha com dados pessoais e profissionais, três questionários referentes aos aspectos vocais e dois questionários para dados relacionados à emoção, sobretudo ansiedade, além da coleta de voz para análise perceptivo-auditiva. Os grupos foram divididos a partir do número de sintomas relatados, estabelecendo um número de 22 voluntários no grupo de Professores Sem Queixa (PSQ e 22 no grupo Professores Com Queixas (PCQ, sendo deste grupo, os indivíduos que relataram mais de três sintomas vocais. Os dados foram analisados estatisticamente. RESULTADOS: a média do número de sintomas descritos no QSSV foi de 5,7 (±2,8 para os PCQ e de 0,8 (±0,9 para os PSQ. Os PSQ referiram uma melhor autoavaliação vocal (p= 0,01 e os PCQ afirmaram possuir um maior comprometimento em sua voz (p= 0,001. O grupo PSQ obteve os maiores valores nos escores do QVV-Físico (p=0,0007 e QVV-Total (p= 0,0006. Os PCQ obtiveram maiores valores no IDV-Total (p=0,0003 e IDV-Orgânico (p=0,0006, e um maior comprometimento emocional, com SRQ de 5,7 (±3,9 e IDATE 42,5 (±12,7. A partir da avaliação perceptivo-auditiva, os PCQ apresentaram um desvio vocal moderado com presença de rugosidade, soprosidade e tensão na voz, enquanto os PSQ evidenciam um desvio leve em todos os parâmetros. CONCLUSÃO: os professores com queixas vocais estão expostos a mais fatores de riscos, além de relatarem mais sintomas e comprometimento vocais, bem como emocionais.

  4. QUALIDADE DE VIDA NO TRABALHO (QVT: UM ESTUDO COM PROFESSORES DOS INSTITUTOS FEDERAIS

    Directory of Open Access Journals (Sweden)

    Rodrigo Ribeiro de Oliveira

    2015-12-01

    Full Text Available No cenário atual em que há exigências contínuas de evolução do conhecimento e de avanços tecnológicos, a educação tecnológica é um assunto que merece destaque, pois é através dela que uma grande parcela dos trabalhadores é formada para atuar no mercado de trabalho cada vez mais qualificado e competitivo. Um dos projetos estratégicos mais importantes na área de ensino no país é o dos Institutos Federais que contam com 562 campi em todo país. Houve um crescimento significativo do quadro funcional: no ano de 2002 contava com 8.999 professores, atualmente conta com 37.021 (2015. Isso mostra um crescimento de 411,39%. Nesse contexto, o objetivo deste trabalho foi analisar o grau de satisfação dos professores dos Institutos Federais em relação à Qualidade de Vida no Trabalho, diante dos impactos da expansão da rede no Brasil. A pesquisa foi realizada com professores que participaram do II Fórum Mundial de Educação Profissional e Tecnológica, realizado em Florianópolis em 2012. Esta pesquisa caracteriza-se como quantitativa, exploratória, descritiva e avaliação (survey. Com relação ao instrumento, foi utilizado o Protocolo Biopsicossocial e organizacional - BPSO-96, de Limongi-França. Foram respondidos 43 questionários. Entre os cinco domínios avaliados, constatou-se que o domínio social foi o que apresentou o menor índice de satisfação (3,193, enquanto que o domínio psicológico foi o que apresentou maior satisfação (6,819. Destaca-se que a variável que apresentou a maior média na pesquisa foi a relação professor-aluno (8,233. Embora os resultados não possam ser generalizados para o expressivo universo de professores do Ensino Técnico dos Institutos Federais, os achados deste estudo demonstram a necessidade de alinhamento quanto à política de gestão de benefícios e apoio familiar e comunitário no grupo pesquisado, revelando a qualidade da relação ensino-aprendizado neste cenário.

  5. Tecnologias e letramento digital: navegando rumo aos desafios

    Directory of Open Access Journals (Sweden)

    Ivanda Martins Silva

    2011-12-01

    Full Text Available Computadores, celulares, redes sociais, ferramentas de pesquisa e interação on-line são recursos utilizados pelos alunos no mundo dinâmico da cibercultura. As tecnologias da informação e comunicação estão exigindo leitores e produtores de textos ainda mais participativos. Aos textos impressos, somam-se os hipertextos e os suportes eletrônicos, que demandam diferentes estratégias de leitura e escrita. Será que a escola consegue criar espaços para as práticas de letramento digital dos alunos? Os professores precisam aprender a gerenciar as tecnologias da informação e comunicação. Ensinar com e para o uso crítico das tecnologias é função primordial da escola no processo de inclusão digital. Nesse sentido, não basta apenas usar aleatoriamente as tecnologias, sem planejamentos ou objetivos claros, mas sim transformar as relações dos sujeitos com os suportes tecnológicos. O presente trabalho discute a inserção das tecnologias na escola e apresenta contribuições para repensar o planejamento didático, considerando a diversidade de recursos tecnológicos que os professores podem utilizar na organização de situações de aprendizagem que levem o aluno a aprimorar as práticas de letramento digital.

  6. Letramento digital e a formação do professor de língua na contemporaneidade

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    Patrícia Fabiana Bedran

    2016-10-01

    Full Text Available Na tentativa de contemplar e repensar a formação do professor sob um viés mais contemporâneo, objetivamos promover uma discussão, a partir da reflexão e articulação de conceitos e perspectivas sobre Letramento Digital (STREET, 1995; BUZATO, 2006; ROJO, 2013 e a Formação Sociocultural do Professor (VIGOTSKI, 1998; 2010; JOHNSON, 2009; FRIEDRICH, 2012, no que se refere ao uso da tecnologia da informação e da comunicação (LÉVY, 1998; 1999; 2007 como responsável por (novas práticas de letramento no âmbito educacional. De forma a instigar uma reflexão sobre a experiência prática à luz da literatura da área, tecemos considerações mais pontuais sobre uma pesquisa qualitativa de cunho etnográfico, realizada em um contexto de formação inicial do profissional de Letras, em que se fez uso da tecnologia com vistas a promover uma formação social, crítica e reflexiva do professor. Os dados evidenciaram que o sucesso da atividade não está relacionado diretamente ao uso de uma ferramenta tecnológica apropriada, mas ao engajamento dos participantes na tarefa solicitada, o que implica necessariamente uma nova forma de pensar e agir, (transformada e delineada por recursos metodológicos, tecnológicos e contextuais.

  7. Prevalência de queixas vocais e estudo de fatores associados em uma amostra de professores de ensino fundamental em Maceió, Alagoas, Brasil

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    Luciano Padilha Alves

    Full Text Available INTRODUÇÃO: A voz é o principal instrumento na vida profissional do professor, requerendo uma adaptação precisa dos órgãos da fonação. O desconhecimento da disfonia em professores de nossa região motivou esta pesquisa. OBJETIVOS: Avaliar a frequência de disfonia em professores do Ensino Fundamental da rede municipal em Maceió-AL e identificar sintomas associados às queixas vocais e possíveis fatores de risco ao aparecimento de alterações vocais. METODOLOGIA: Estudo transversal abrangendo 126 docentes selecionados aleatoriamente, avaliados a partir de entrevista, com aplicação de questionário dirigido, em 2008. RESULTADOS: Dos 126 professores avaliados, 87,3% referiram ocorrência de disfonia na docência. Observou-se relação entre carga horária semanal e presença de disfonia (p=0,0038. Em relação ao ambiente de trabalho, poeira e ambiente seco foram as queixas mais relatadas, ambas apresentando associação significativa (p<0,04. Os sintomas de obstrução nasal, prurido, tosse e dispepsia apresentaram relação com a presença de rouquidão. Não houve associação entre disfonia e tabagismo ou tabagismo passivo (p<0,6. CONCLUSÃO: O estudo permitiu concluir que existe elevada prevalência de disfonia no grupo estudado e que o comprometimento vocal na atividade docente está relacionado aos fatores ambientais, bem como a sintomas clínicos associados à rinopatia e ao refluxo gastroesofágico.

  8. In commemoration of professor V.P. Karpov

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    Semyonova L.S.

    2013-10-01

    Full Text Available This article is about professor Karpov V.P., a prominent scientist, first rector of Yekaterinoslav Medical Academy. Biography of a great investigator, his main achievements in the area of histology, biology, theory and history of medicine was studied. Professor Karpov V.P. always combined his great scientific, organizational and research work with social activity. Monographs of professor Karpov V.P. and conferences organized by him were of great importance in the solution of such new problems as theary of microscope and cell amitosis. Professor Karpov is a founder of a large school of histology. Thanks to his active participation and personal guidance, in 1917 department of histology was founded in Yekaterinoslav Medical Institute. The author of the article has analyzed Hippocrates` works translated into Russian by professor Karpov V.P. and pointed out their significance for modern medical science and practice.

  9. Professor I I Glass A Tribute and Memorial

    CERN Document Server

    Igra, Ozer

    2013-01-01

    The book provides personal memories along with description of scientific works written by ex-graduate students and research associates of the late Professor Glass. The described research work covers a wide range of shock wave phenomena, resulting from seeds planted by Professor Glass. Professor Glass was born in Poland in 1918. He immigrated together with his parents to Canada at the age of 12 and received all his professional education at the University of Toronto, Canada. He became a world recognized expert in shock wave phenomena, and during his 45 years of active research he supervised more than 125 master and doctoral students, post-doctoral fellows and visiting research associates. In this book seven of his past students/research-associates describe their personal memories of Professor Glass and present some of their investigations in shock wave phenomena which sprung from their past work with Professor Glass. Specifically, these investigations include underwater shock waves, shock/bubble interaction, m...

  10. Clinical and genetic study of a juvenile-onset Huntington disease

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    HAO Ying

    2012-06-01

    Full Text Available Background Huntington's disease (HD is an autosomal dominant hereditary progressive neurodegenerative disorder with a distinct phenotype characterized by chorea, dementia, cognitive and affective impairment. There are selective neural cell loss and atrophy in the caudate and putamen. Dr. George Huntington firstly described the disease accurately and insightfully, which led to a widespread recognition of the inherited chorea that now bears his name. Huntington disease gene (IT15 locus on chromosome 4p16.3, and encompasses 67 exons with a trinucleotide repeat (CAG in the first exon. The CAG repeat length is highly polymorphic in the population and expanded on at least one chromosome of individuals with HD. Clinically, patient with HD are often onset in adulthood. Juvenile-onset HD is relatively rare. Adult-onset HD patients usually have a CAG expansion from 40 to 55 whereas those with juvenile-onset greater than 60 which are often inherited from the father. We investigated the clinical features of a juvenile-onset case with Huntington disease and dynamic mutation of his family. Methods The CAG repeats of IT15 gene were detected using polymerase chain reaction and capillary electrophoresis in 115 individuals with preliminary diagnosis as Huntington disease. The repeat numbers of some samples carried expanded or intermediate alleles were verified by the pMD18-T vector clone sequencing. Results Fragment analysis showed that one juvenile-onset case presenting with cognitive dysfunction and hypokinesis carried 15/68 CAG repeats of IT15. His father carried 17/37 and mother carried 15/17. Conclusion 1 The juvenile-onset case of HD presented with different clinical features compared with adult-onset cases. The typical signs of adult-onset cases include progressive chorea, rigidity and dementia. The most common sign of juvenile-onset Huntington disease is cognitive decline. 2 The dynamic mutation of IT15 gene expansion of the CAG repeats in the

  11. Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.

    Science.gov (United States)

    Cisbani, Giulia; Maxan, Alexander; Kordower, Jeffrey H; Planel, Emmanuel; Freeman, Thomas B; Cicchetti, Francesca

    2017-11-01

    Cell replacement has been explored as a therapeutic strategy to repair the brain in patients with Huntington's and Parkinson's disease. Post-mortem evaluations of healthy grafted tissue in such cases have revealed the development of Huntington- or Parkinson-like pathology including mutant huntingtin aggregates and Lewy bodies. An outstanding question remains if tau pathology can also be seen in patients with Huntington's and Parkinson's disease who had received foetal neural allografts. This was addressed by immunohistochemical/immunofluorescent stainings performed on grafted tissue of two Huntington's disease patients, who came to autopsy 9 and 12 years post-transplantation, and two patients with Parkinson's disease who came to autopsy 18 months and 16 years post-transplantation. We show that grafts also contain tau pathology in both types of transplanted patients. In two patients with Huntington's disease, the grafted tissue showed the presence of hyperphosphorylated tau [both AT8 (phospho-tau Ser202 and Thr205) and CP13 (pSer202) immunohistochemical stainings] pathological inclusions, neurofibrillary tangles and neuropil threads. In patients with Parkinson's disease, the grafted tissue was characterized by hyperphosphorylated tau (AT8; immunofluorescent staining) pathological inclusions, neurofibrillary tangles and neuropil threads but only in the patient who came to autopsy 16 years post-transplantation. Abundant tau-related pathology was observed in the cortex and striatum of all cases studied. While the striatum of the grafted Huntington's disease patient revealed an equal amount of 3-repeat and 4-repeat isoforms of tau, the grafted tissue showed elevated 4-repeat isoforms by western blot. This suggests that transplants may have acquired tau pathology from the host brain, although another possibility is that this was due to acceleration of ageing. This finding not only adds to the recent reports that tau pathology is a feature of these neurodegenerative

  12. CURRÍCULO TEMÁTICO FUNDAMENTADO EM FREIRE-CTS: ENGAJAMENTO DE PROFESSORES DE FÍSICA EM FORMAÇÃO INICIAL

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    Caetano Castro Roso

    Full Text Available Este trabalho resultou da reflexão sobre vivência de professores (as de física, em formação inicial, com a abordagem temática fundamentada em Freire-CTS. Buscamos responder à pergunta: como professores (as em formação inicial posicionam-se frente à possibilidade de realizar encaminhamentos curriculares pautados pela abordagem temática durante seu estágio curricular e/ou no decorrer da sua atuação profissional? Utilizamos a Análise Textual Discursiva para analisar questionários respondidos por esses professores (as ao final do trabalho. Como resultados, identificamos três categorias articuladas ao currículo: (i da fragmentação disciplinar à interdisciplinaridade, (ii temas da realidade dos estudantes como ponto de partida e (iii abordagem temática: reconfiguração curricular ou nova metodologia? Ao final, sinalizamos desafios e potencialidades de currículos temáticos.

  13. OBITUARY: Professor Jan Evetts in memoriam

    Science.gov (United States)

    Dew-Hughes, David; Campbell, Archie; Glowacki, Bartek

    2005-11-01

    It is with great sadness that we report the death of Jan Evetts, who lost his second battle with cancer on 18 August 2005. In 1988 he was appointed Founding Editor of this journal where his leadership created the foundation upon which its success rests today. He made an outstanding series of contributions to the science of superconductivity and to the understanding of superconducting materials, and was an indefatigable champion of the development of applications of superconductivity. The loss to the scientific community is incalculable, as is attested by the many communications received from colleagues throughout the world. Professor Jan Edgar Evetts (1939-2005) Professor Jan Edgar Evetts (1939-2005) Jan was born on 31 March 1939, and attended the Dragon School in Oxford, and later Haileybury. He was awarded an exhibition to read Natural Sciences at Pembroke College, Cambridge in 1958 and took his BA degree in 1961. He then undertook a Certificate of Postgraduate Study in Physics under the supervision of Professor Neville Mott. He was the first student to undertake this newly-instituted course; the title of his thesis was `The Resistance of Transition Metals'. In 1962 he joined David Dew-Hughes' embryonic superconducting materials research group, along with Archie Campbell and Anant Narlikar. In fact it was Jan's enthusiasm for the proposed course of research that helped convince David that he should follow Professor Alan Cottrell's suggestion to apply metallurgical methodology to the study of the factors that controlled critical current density in the type II superconductors that were then under development for applications in magnets. Competing theories for the critical current density at that time were fine filaments or `Mendelssohn Sponge' versus the pinning of Abrikosov quantized vortices. The results of the group's work, to which Jan made a major contribution, came down heavily in favour of the latter theory. Jan's outstanding characteristic was his

  14. Impacto vocal de professores Teachers' vocal impact

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    Adriana Ricarte

    2011-08-01

    Full Text Available OBJETIVO: analisar o impacto vocal nas atividades diárias em professores do ensino médio. Correlacionar os achado da auto-percepção do problema vocal com os aspectos: efeitos no trabalho, na comunicação diária, na comunicação social e na sua emoção. MÉTODOS: a amostra foi constituída por 107 professores, sendo 86 com queixa e 21 sem queixa, selecionados em escolas da rede particular de ensino de Maceió-AL. Cada professor respondeu individualmente o protocolo Perfil Participação em Atividades Vocais na presença da pesquisadora, assinalando suas respostas em uma escala visual que varia de 0 a 10. O protocolo é composto por 28 questões com a presença integrada em cinco aspectos englobados para avaliar a qualidade de vida e o resultado de tratamentos vocais. O protocolo oferece, ainda, dois escores adicionais: pontuação de limitação nas atividades (PLA e de restrição de participação (PRP. RESULTADOS: na comparação dos grupos com e sem queixa vocal foram verificados que todos os resultados foram estatisticamente significantes (pPURPOSE: to analyze the vocal impact in the daily activities on high-school teachers. Correlate the finding of the auto-perception on the vocal problem with the following aspects: effects in the work, daily communication, social communication and, its emotion METHODS: the sample consisted of 107 teachers, 86 with and 21 with no complaint, selected from private teaching schools in Maceió-AL. Each teacher answered individually the Protocol for Voice Activity Participation Profile in the presence of the researcher, noting their responses on a visual scale ranging from 0 to 10. The protocol is composed of 28 questions with the presence integrated in five aspects to evaluate the quality of life and the result of vocal treatments. The protocol offers, still, two additional scores: punctuation of limitation in the activities (PLA and restriction of participation (PRP. RESULTS: comparing the groups with

  15. Formação pedagógica de professores de nutrição: uma omissão consentida? Teacher training for nutrition professors: a tacitly accepted omission?

    OpenAIRE

    Nilce Maria da Silva Campos Costa

    2009-01-01

    Apesar dos novos papéis preconizados pelas Diretrizes Curriculares Nacionais aos profissionais de Nutrição, pouca atenção tem sido dada ao desenvolvimento docente para atuação nos novos cenários. O objetivo deste ensaio é o de discutir um dos desafios à formação do nutricionista, a prática docente e a formação pedagógica do professor da área da saúde, para pensar formas de oportunizar um ensino de melhor qualidade, com base em autores que discutem a docência universitária. Identificam-se como...

  16. Plataforma Blackboard: treinamento dos professores para a eficácia na EaD

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    Daniel Serravalle de Sá

    2010-08-01

    Full Text Available http://dx.doi.org/10.5007/1807-9288.2010v6n1p124 O presente artigo faz considerações sobre o uso da plataforma Blackboard Academic Suite como ferramenta de ensino no âmbito do Departamento de Espanhol, Português e Estudos Latino-Americanos (SPLAS na Universidade de Manchester. O que se oferece é um depoimento da experiência do autor enquanto um professor-usuário dessa tecnologia aplicada ao ensino. Reflete-se aqui sobre as funcionalidades da plataforma e a questão do treinamento necessário para utilização plena do programa e o sucesso da experiência educativa.

  17. Ser professor na Educação Básica: letramentos em construção em um Curso de Letras

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    Adriana Fischer

    2011-12-01

    Full Text Available O objetivo deste trabalho é caracterizar como ocorre a constituição letrada de alunos de Letras quando assumem a posição de professores da Educação Básica. Para responder a este objetivo, são analisados movimentos dialógicos desses alunos em eventos de letramento acadêmico nomeados como identitários. Nestes, os alunos universitários são posicionados como professores em práticas que envolvem leitura e a produção escrita. Para melhor situar os sentidos desses movimentos, são analisados os motivos pelos quais eles optaram pelo Curso de Letras. A perspectiva sociocultural dos letramentos orienta as discussões dos dados coletados mediante o acompanhamento longitudinal dos sujeitos da pesquisa em duas disciplinas do primeiro ano do curso. Os resultados indicam que as escolhas no projeto didático do professor universitário dessas disciplinas, bem como a possibilidade de os alunos se posicionarem como corresponsáveis em eventos destinados ao ensino-aprendizagem da língua, são fatores determinantes na constituição letrada deles quando na posição de professores da Educação Básica. Palavras-chave: Curso de Letras. Letramentos. Eventos identitários. Formação de professores.

  18. CARTOGRAFIAS AFETIVAS: PROPOSIÇÕES DO PROFESSOR-ARTISTA-CARTÓGRAFO-ETC

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    Juliana Cristina Pereira

    2014-04-01

    Full Text Available O poema Sobre Importâncias de Manoel de Barros que abre a apresentação desta pesquisa, Cartografias Afetivas: proposições do professor-artista-cartógrafo-etc., aponta para um sentido pessoal e íntimo de atribuir importâncias, dando especial valor para aquilo que afeta sensivelmente, retendo o que cada um seleciona e atualiza ao longo da vida. A passagem descrita acima de Manoel de Barros diz que “a importância de uma coisa há que ser medida pelo encantamento que a coisa produza em nós”; isto impulsiona a refletir não só sobre nossas importâncias, mas, também sobre a importância do outro. O que o outro, aquele que é conhecido e também o desconhecido, elege como importância em sua experiência de vida, e, se pudesse selecionar, cartografar alguns momentos, experiências íntimas ou coletivas, para compartilhar com o outro, para torná-las públicas, o que compartilharia? Assim, Cartografias Afetivas busca, a partir de uma proposição aberta, criar cartografias diversas, construindo coletivamente reflexões acerca do ser professor-artista-cartógrafo-etc. A proposta tem o intuito de potencializar afeto e provocar encontros e atravessamentos em redes na criação de cartografias, propondo outros modos de pensar a relação com a educação, com arte, com a vida e suas importâncias. Nessa relação, o professor-artista-cartógrafo-etc., na contemporaneidade, desenha seu percurso em constante conexão com o que acontece no espaço/arte/tempo/vida.

  19. A identidade profissional do professor: um estudo de revisão sistemática

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    Patrícia Maria Silva Gomes

    2013-06-01

    Full Text Available O presente estudo é uma revisão sistemática da literatura cujo objetivo foi cartografar a tipologia de estudos empíricos realizados acerca da Identidade Profissional do professor. A pesquisa foi efetuada nas bases de dados eletrônicas ISI Web of Knowledge, ERIC, SPORTDiscus e SCOPUS entre 2001 e 2012. As equações de pesquisa foram "Professional Identity" AND "Teacher", no campo título e "Professional Identity" AND "Teacher" AND "Physical Education", no campo "Abstract", tendo sido integrados 42 artigos. A análise de conteúdo, com categorias definidas "a priori", foi a técnica utilizada: a foco do estudo; b ano e local de publicação; c objetivos; d participantes; e instrumentos e f principais conclusões. Os resultados evidenciaram um aumento da pesquisa na área e nas metodologias qualitativas. Estas colocam o desenvolvimento profissional como elemento central no processo de (reconstrução da Identidade Profissional, sendo que ao nível do professor de Educação Física a pesquisa ainda é escassa.

  20. Indicadores de estresse e estratégias de enfrentamento em professores de ensino multisseriado

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    Kelly Ambrósio Silveira

    Full Text Available Ensinar em classes multisseriadas pode ser estressante, especialmente em zonas rurais, devido ao deslocamento e falta de recursos. Este estudo identificou estressores percebidos no trabalho, avaliou o estresse, a ansiedade e as estratégias de enfrentamento correlacionando-os com variáveis pessoais e do trabalho de 21 professores responsáveis por duas a três séries/classe, com 16,4 alunos, em média. Identificou-se, em 57% da amostra, estresse relacionado à ansiedade (moderada a grave em 30%. Os estressores mais frequentes foram pouco acompanhamento familiar e problemas motivacionais e comportamentais dos alunos. Predominaram estratégias de enfrentamento baseadas na solução de problemas, especialmente entre professores sem estresse e/ou com mais séries/classe, seguidas de busca de práticas religiosas. Estas se correlacionaram com a busca de suporte social e com o tempo de serviço, especialmente entre os casados e aqueles com menos séries/turmas. São necessários mais estudos sobre o impacto do contexto de ensino multisseriado na saúde mental dos docentes.

  1. Liberdade esclarecida: a formação de professores nos anos 1930

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    Regina Cândida Ellero Gualtieri

    2013-11-01

    Full Text Available Os temas considerados importantes para o exercício da docência, no início dos anos 1930, abordados na Revista Escola Nova, são analisados com o intuito de caracterizar as orientações pedagógicas oferecidas, na época, pelo Estado aos professores. Trata-se de uma publicação oficial, editada em São Paulo pela Diretoria da Instrução Pública, no período assinalado, e concebida para apoiar tecnicamente os professores em seus fazeres e, sobretudo, esclarecer os fundamentos da reforma educacional em curso. Nessa época, o diretor da Instrução Pública de São Paulo era o escolanovista Lourenço Filho (1897-1970, responsável pelas diretrizes e pela implementação da reforma. A análise dos conteúdos revela um conjunto de princípios, normas e prescrições que visavam estabelecer condutas, modos de ver a escola e de praticar o ensino que, no dizer de Lourenço Filho, compunham a “nascente cultura pedagógica nacional”. O propósito dessa análise é também refletir sobre a persistência, ou não, de certos traços desse ideário nas práticas escolares atuais.

  2. A LEITURA NA FORMAÇÃO INICIAL DO PROFESSOR: O FORMADOR EM CENA

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    Sandro Luís da Silva

    2011-05-01

    Full Text Available O objetivo deste texto é relatar uma pesquisa sobre o trabalho com leitura na formação inicial do professor de língua portuguesa.  Adotou-se uma abordagem qualitativa na busca de informações junto a três informantes de curso de Letras de três Instituições de Ensino Superior - IES do Estado de São Paulo. O estudo baseou-se, sobretudo, em Veiga (1998, Pimenta e Anastasiou (2002, Kaufman & Rodriguez (1995, Solé (1998, Silva (2005, Schneuwly & Dolz (2004; a LDBN (1996; as Propostas Curriculares do Curso de Letras; o Parecer 9/2001 do MEC; e o Projeto Pedagógico do Curso de cada uma das IES. Observou-se que o curso superior ainda apresenta defasagens em relação ao trabalho com a leitura, havendo necessidade de se pensar em estratégias que tornem a leitura significativa para o futuro professor.  Palavras-chave: Leitura. Formação. Estratégia.

  3. Criança Autista: Pais e Professores – Uma Parceria de Sucesso no Desenvolvimento de Competências

    Directory of Open Access Journals (Sweden)

    C. Cruz

    2016-02-01

    Conclusões: Apesar das dificuldades manifestadas, o desempenho escolar desta criança é igual ou superior ao dos colegas, segundo as afirmações do professor e do pai: “Aproveitamento muito bom. A avaliação é igual à dos outros colegas, sendo o plano de estudos igual”. Consideramos, com base nos resultados do estudo, que, como em outras perturbações psicopatológicas, face ao diagnóstico, não podemos tecer generalizações. O envolvimento afectivo e acompanhamento especializado são aspectos de importância maior no desenvolvimento e prognóstico das perturbações mentais. Existem no indivíduo competências que devem ser identificadas e potencializadas, visando um maior nível de autonomia e satisfação pessoal.

  4. Radiation sensitivity of fibroblast strains from patients with Usher's syndrome, Duchenne muscular dystrophy, and Huntington's disease

    International Nuclear Information System (INIS)

    Nove, J.; Little, J.B.; Tarone, R.E.; Robbins, J.H.

    1987-01-01

    The colony-forming ability of 10 normal human fibroblast cell strains and of 10 strains representing 3 degenerative diseases of either nerve or muscle cells was determined after exposure of the cells to X-rays or β-particles from tritiated water. Both methods of irradiation yielded similar comparative results. The fibroblast strains from the 5 Usher's syndrome patients and from 1 of the 2 Huntington's disease patients were hypersensitive to radiation, while those from the 3 Duchenne muscular dystrophy patients and the second Huntington's disease patient had normal sensitivity to radiation. These results indicate both disease-specific and strain-specific differences in the survival of fibroblasts after exposure to ionizing radiation. 38 refs.; 2 figs.; 3 tabs

  5. Huntington's disease predictive testing: the case for an assessment approach to requests from adolescents.

    Science.gov (United States)

    Binedell, J; Soldan, J R; Scourfield, J; Harper, P S

    1996-01-01

    Adolescents who are actively requesting Huntington's predictive testing of their own accord pose a dilemma to those providing testing. In the absence of empirical evidence as regards the impact of genetic testing on minors, current policy and guidelines, based on the ethical principles of non-maleficence and respect for individual autonomy and confidentiality, generally exclude the testing of minors. It is argued that adherence to an age based exclusion criterion in Huntington's disease predictive testing protocols is out of step with trends in UK case law concerning minors' consent to medical treatment. Furthermore, contributions from developmental psychology and research into adolescents' decision making competence suggest that adolescents can make informed choices about their health and personal lives. Criteria for developing an assessment approach to such requests are put forward and the implications of a case by case evaluation of competence to consent in terms of clinicians' tolerance for uncertainty are discussed. PMID:8950670

  6. Reflexões de professores de inglês em formação sobre o uso de Webquests Interativas e Adaptáveis no processo de ensino e aprendizagem da língua inglesa

    Directory of Open Access Journals (Sweden)

    Camila Gonçalves dos Santos do Canto

    2016-03-01

    Full Text Available Resumo: O presente estudo, de cunho qualitativo, é um recorte da tese de doutorado da autora a qual propôs um novo modelo de Webquest voltado ao ensino de línguas por meio de um sistema interativo de autoria - a ferramenta Elo Cloud. Os resultados aqui apresentados voltam-se ao papel reflexivo de futuros professores de língua inglesa quanto ao uso das Webquests Interativas e Adaptáveis nas práticas de ensino e aprendizagem de línguas. As reflexões feitas a partir da fala dos professores em formação demonstraram que as Webquests Interativas e Adaptáveis são potencializadoras no processo de aprendizagem de línguas por fornecerem conteúdos interativos e dinâmicos que focam no aprendizado da língua inglesa.

  7. Professor Wind i Deadline om Spitzenkandidaten

    DEFF Research Database (Denmark)

    2018-01-01

    Professor og centerleder, Marlene Wind, var fredag den 23. februar 2018 i DR2 Deadline for at snakke om proceduren bag udvælgelsen af en ny formand for Europa Kommissionen. Professer Wind forklarede blandt andet, hvordan Europa Parlamentet, siden Lisabon Traktaten i 2009, har fortolket en del af...... traktaten til, at det skal være det vindende parti ved EP-valget, som vælger Kommissionsformanden. Dette er kendt som Spitzenkandidaten-proceduren. Wind pointerede, at særligt tyskerne har den holdning til EU, at den primære legitimitet ligger hos Europa parlamentet, da det er det eneste direkte folkevalgte...... organ i EU. Wind påpegede, at statsoverhovederne har været meget skeptiske eller direkte imod proceduren, men at der er en stigende holdning til, at proceduren kan være med til at sikre borgerinddragelse i EU. Til dette sagde Wind; "Hvis man skal engangere borgerne ved det her valg, hvor stort set ingen...

  8. Memories of Professor Sugimoto and isotope separator

    International Nuclear Information System (INIS)

    Tanaka, Kazuhiro

    2013-01-01

    Usual magnetic isotope-separators select the particles with the same Z/A value which may include different nuclides. Identification of the isotope with the same Z/A value but different Z or A value is an universal requirement for nuclear physics experiments. If one knows, together with the A/Z value, the dE/dx or the range of the isotope in some energy absorber, which are the function of Z 2 /A, its nuclide can be specified. This idea can be realized by arranging proper energy-absorber at the focal point of magnetic analyzer. The author proposes another novel method in which two dipole-magnets are excited with some difference, and an energy absorber corresponding to that energy difference is situated between two magnets. It can also be devised so that the dispersion at the final focal-point depends only on the emission angle of the isotope at production. Professor Sugimoto recognized the significance of this scheme and proposed to employ it in the experiment at BEVATRON. The unbalanced two dipole-magnets method is employed at RIKEN and RCNP, Osaka University. The author's creative idea originated in Sugimoto Laboratory at Osaka University. (author)

  9. Editorial: A dedication to Professor Jan Evetts

    Science.gov (United States)

    Weber, Harald; Dew-Hughes, David; Campbell, Archie; Barber, Zoe; Somekh, Rob; Glowacki, Bartek

    2006-03-01

    A few days before the beginning of the 7th European Conference on Applied Superconductivity we learned that Professor Jan Evetts, a pioneer of superconductor research, a brilliant scientist, a wonderful person and a great personal friend, had passed away. We therefore decided to dedicate the 7th European Conference on Applied Superconductivity to the memory of Jan Evetts. The following citation is based on material provided by his former supervisor (D Dew-Hughes) and his closest co-workers in Cambridge. Professor Jan Edgar Evetts (1939-2005) Professor Jan Edgar Evetts (1939-2005) Jan Evetts passed away after losing his second battle with cancer on 24th August 2005. He made an outstanding series of contributions to the science of superconductivity and to the understanding of superconducting materials and was an indefatigable champion of the development of applications of superconductivity. The loss to the superconductivity community is incalculable, as attested by the many communications received from colleagues throughout the world. Jan was born on 31 March 1939, and attended the Dragon School in Oxford, and later Haileybury. He was awarded an exhibition to read Natural Sciences at Pembroke College, Cambridge. He entered the college in 1958 and took his BA degree in 1961. He then undertook a Certificate of Postgraduate Study in Physics under the supervision of Professor Neville Mott. He was the first student to undertake this newly-instituted course; the title of his thesis was `The Resistance of Transition Metals'. In 1962 he joined David Dew-Hughes' superconducting materials research group, along with Archie Campbell and Anant Narlikar. In fact it was Jan's enthusiasm for the proposed course of research that helped convince David that he should follow Professor Alan Cottrell's suggestion to apply metallurgical methodology to the study of the factors that controlled critical current density in the type II superconductors that were then under development for

  10. Grunting in genetically modified minipig animal model for Huntington ´s disease - a pilot experiment

    Czech Academy of Sciences Publication Activity Database

    Tykalová, T.; Hlavnička, J.; Mačáková, Monika; Baxa, Monika; Cmejla, R.; Motlík, Jan; Klempíř, J.; Rusz, J.

    2015-01-01

    Roč. 78, Suppl 2 (2015), s. 12-13 ISSN 1210-7859. [Conference on Animal Models for neurodegenerative Diseases /3./. 08.11.2015-10.11.2015, Liblice] R&D Projects: GA MŠk ED2.1.00/03.0124; GA MŠk(CZ) 7F14308 Institutional support: RVO:67985904 Keywords : Huntington ´s disease * mitochondria * DNA damage Subject RIV: FH - Neurology

  11. Double strand DNA breaks response in Huntington´s disease

    Czech Academy of Sciences Publication Activity Database

    Šolc, Petr; Valášek, Jan; Rausová, Petra; Juhásová, Jana; Juhás, Štefan; Motlík, Jan

    2015-01-01

    Roč. 78, Suppl 2 (2015), s. 15-15 ISSN 1210-7859. [Conference on Animal Models for neurodegenerative Diseases /3./. 08.11.2015-10.11.2015, Liblice] R&D Projects: GA MŠk ED2.1.00/03.0124; GA MŠk(CZ) 7F14308 Institutional support: RVO:67985904 Keywords : Huntington ´s disease * DNA damage * double strand DNA breaks Subject RIV: FH - Neurology

  12. Dynamics of the connectome in Huntington's disease: A longitudinal diffusion MRI study

    OpenAIRE

    Odish, Omar F.F.; Caeyenberghs, Karen; Hosseini, Hadi; van den Bogaard, Simon J.A.; Roos, Raymund A.C.; Leemans, Alexander

    2015-01-01

    Abstract Objectives To longitudinally investigate the connectome in different stages of Huntington's disease (HD) by applying graph theoretical analysis to diffusion MRI data. Experimental design We constructed weighted structural networks and calculated their topological properties. Twenty-two premanifest (preHD), 10 early manifest HD and 24 healthy controls completed baseline and 2 year follow-up scans. We stratified the preHD group based on their predicted years to disease onset into a far...

  13. Minipig Model of Huntington's Disease: H-1 Magnetic Resonance Spectroscopy of the Brain

    Czech Academy of Sciences Publication Activity Database

    Jozefovičová, M.; Herynek, V.; Jírů, F.; Dezortová, M.; Juhásová, Jana; Juhás, Štefan; Motlík, Jan; Hájek, M.

    2016-01-01

    Roč. 65, č. 1 (2016), s. 155-163 ISSN 0862-8408 R&D Projects: GA TA ČR(CZ) TA01011466; GA MŠk(CZ) 7F14308; GA MŠk ED2.1.00/03.0124 Institutional support: RVO:67985904 Keywords : Huntington´s disease * minipigs * magnetic resonance spectroscopy Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.461, year: 2016

  14. Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

    DEFF Research Database (Denmark)

    Benraiss, Abdellatif; Wang, Su; Herrlinger, Stephanie

    2016-01-01

    The causal contribution of glial pathology to Huntington disease (HD) has not been heavily explored. To define the contribution of glia to HD, we established human HD glial chimeras by neonatally engrafting immunodeficient mice with mutant huntingtin (mHTT)-expressing human glial progenitor cells...... chimeras are hyperexcitable. Conversely, normal glia can ameliorate disease phenotype in transgenic HD mice, as striatal transplantation of normal glia rescues aspects of electrophysiological and behavioural phenotype, restores interstitial potassium homeostasis, slows disease progression and extends...

  15. The Effect of Music Therapy in Patients with Huntington's Disease: A Randomized Controlled Trial.

    Science.gov (United States)

    van Bruggen-Rufi, Monique C H; Vink, Annemieke C; Wolterbeek, Ron; Achterberg, Wilco P; Roos, Raymund A C

    2017-01-01

    Music therapy may have beneficial effects on improving communication and expressive skills in patients with Huntington's disease (HD). Most studies are, however, small observational studies and methodologically limited. Therefore we conducted a multi-center randomized controlled trial. To determine the efficacy of music therapy in comparison with recreational therapy in improving quality of life of patients with advanced Huntington's disease by means of improving communication. Sixty-three HD-patients with a Total Functional Capacity (TFC) score of ≤7, admitted to four long-term care facilities in The Netherlands, were randomized to receive either group music therapy or group recreational therapy in 16 weekly sessions. They were assessed at baseline, after 8, 16 and 28 weeks using the Behaviour Observation Scale for Huntington (BOSH) and the Problem Behaviour Assessment-short version (PBA-s). A linear mixed model with repeated measures was used to compare the scores between the two groups. Group music therapy offered once weekly for 16 weeks to patients with Huntington's disease had no additional beneficial effect on communication or behavior compared to group recreational therapy. This was the first study to assess the effect of group music therapy on HD patients in the advanced stages of the disease. The beneficial effects of music therapy, recorded in many, mainly qualitative case reports and studies, could not be confirmed with the design (i.e. group therapy vs individual therapy) and outcome measures that have been used in the present study. A comprehensive process-evaluation alongside the present effect evaluation is therefore performed.

  16. EMQN/CMGS best practice guidelines for the molecular genetic testing of Huntington disease

    OpenAIRE

    Losekoot, Monique; van Belzen, Martine J; Seneca, Sara; Bauer, Peter; Stenhouse, Susan A R; Barton, David E

    2012-01-01

    Huntington disease (HD) is caused by the expansion of an unstable polymorphic trinucleotide (CAG)n repeat in exon 1 of the HTT gene, which translates into an extended polyglutamine tract in the protein. Laboratory diagnosis of HD involves estimation of the number of CAG repeats. Molecular genetic testing for HD is offered in a wide range of laboratories both within and outside the European community. In order to measure the quality and raise the standard of molecular genetic testing in these ...

  17. Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington's disease

    OpenAIRE

    Mealer, Robert G.; Subramaniam, Srinivasa; Snyder, Solomon H.

    2013-01-01

    Although the mutated protein causing Huntington's disease (HD) is expressed throughout the body, the major pathology of HD is localized to the striatum of the brain. We previously reported that the striatal-enriched protein Rhes binds the mutated huntingtin protein and enhances its cytotoxicity. We now demonstrate that Rhes-deleted mice are dramatically protected from neurotoxicity and motor dysfunction in a striatal-specific model of HD elicited by 3-nitropropionic acid. This finding suggest...

  18. Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study.

    Science.gov (United States)

    2008-12-01

    To determine whether ethyl-eicosapentaenoic acid (ethyl-EPA), an omega-3 fatty acid, improves the motor features of Huntington disease. Six-month multicenter, randomized, double-blind, placebo-controlled trial followed by a 6-month open-label phase without disclosing initial treatment assignments. Forty-one research sites in the United States and Canada. Three hundred sixteen adults with Huntington disease, enriched for a population with shorter trinucleotide (cytosine-adenine-guanine) repeat length expansions. Random assignment to placebo or ethyl-EPA, 1 g twice a day, followed by open-label treatment with ethyl-EPA. Six-month change in the Total Motor Score 4 component of the Unified Huntington's Disease Rating Scale analyzed for all research participants and those with shorter cytosine-adenine-guanine repeat length expansions (<45). At 6 months, the Total Motor Score 4 point change for patients receiving ethyl-EPA did not differ from that for those receiving placebo. No differences were found in measures of function, cognition, or global impression. Before public disclosure of the 6-month placebo-controlled results, 192 individuals completed the open-label phase. The Total Motor Score 4 change did not worsen for those who received active treatment for 12 continuous months compared with those who received active treatment for only 6 months (2.0-point worsening; P=.02). Ethyl-EPA was not beneficial in patients with Huntington disease during 6 months of placebo-controlled evaluation. Clinical Trial Registry clinicaltrials.gov Identifier: NCT00146211.

  19. Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease

    OpenAIRE

    Keene, C. Dirk; Rodrigues, Cecilia M. P.; Eich, Tacjana; Chhabra, Manik S.; Steer, Clifford J.; Low, Walter C.

    2002-01-01

    Huntington's disease (HD) is an untreatable neurological disorder caused by selective and progressive degeneration of the caudate nucleus and putamen of the basal ganglia. Although the etiology of HD pathology is not fully understood, the observed loss of neuronal cells is thought to occur primarily through apoptosis. Furthermore, there is evidence in HD that cell death is mediated through mitochondrial pathways, and mitochondrial deficits are commonly associated with HD. We have previously r...

  20. SRAO: the first southern robotic AO system

    Science.gov (United States)

    Law, Nicholas M.; Ziegler, Carl; Tokovinin, Andrei

    2016-08-01

    We present plans for SRAO, the first Southern Robotic AO system. SRAO will use AO-assisted speckle imaging and Robo-AO-heritage high efficiency observing to confirm and characterize thousands of planet candidates produced by major new transit surveys like TESS, and is the first AO system to be capable of building a comprehensive several-thousand-target multiplicity survey at sub-AU scales across the main sequence. We will also describe results from Robo-AO, the first robotic LGS-AO system. Robo-AO has observed tens of thousands of Northern targets, often using a similar speckle or Lucky-Imaging assisted mode. SRAO will be a moderate-order natural-guide-star adaptive optics system which uses an innovative photoncounting wavefront sensor and EMCCD speckle-imaging camera to guide on faint stars with the 4.1m SOAR telescope. The system will produce diffraction-limited imaging in the NIR on targets as faint as mν = 16. In AO-assisted speckle imaging mode the system will attain the 30-mas visible diffraction limit on targets at least as faint as mν = 17. The system will be the first Southern hemisphere robotic adaptive optics system, with overheads an order of magnitude smaller than comparable systems. Using Robo-AO's proven robotic AO software, SRAO will be capable of observing overheads on sub-minute scales, allowing the observation of at least 200 targets per night. SRAO will attain three times the angular resolution of the Palomar Robo-AO system in the visible.

  1. Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.

    Science.gov (United States)

    Ramos, Eliana Marisa; Gillis, Tammy; Mysore, Jayalakshmi S; Lee, Jong-Min; Alonso, Isabel; Gusella, James F; Smoller, Jordan W; Sklar, Pamela; MacDonald, Marcy E; Perlis, Roy H

    2015-06-01

    Huntington's disease is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms that are caused by huntingtin gene (HTT) CAG trinucleotide repeat alleles of 36 or more units. A greater than expected prevalence of incompletely penetrant HTT CAG repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease. We assessed the distribution of HTT CAG repeat alleles in a cohort of individuals with bipolar disorder. HTT CAG allele sizes from 2,229 Caucasian individuals diagnosed with DSM-IV bipolar disorder were compared to allele sizes in 1,828 control individuals from multiple cohorts. We found that HTT CAG repeat alleles > 35 units were observed in only one of 4,458 chromosomes from individuals with bipolar disorder, compared to three of 3,656 chromosomes from control subjects. These findings do not support an association between bipolar disorder and Huntington's disease. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  2. Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature

    Directory of Open Access Journals (Sweden)

    Christopher G. Tarolli

    2017-04-01

    Full Text Available Background Huntington disease is a fatal, autosomal dominant, neurodegenerative disorder manifest by the triad of a movement disorder, behavioral disturbances, and dementia. At present, no curative or disease modifying therapies exist for the condition and current treatments are symptomatic. Palliative care is an approach to care that focuses on symptom relief, patient and caregiver support, and end of life care. There is increasing evidence of the benefit of palliative care throughout the course of neurodegenerative conditions including Parkinson disease and amyotrophic lateral sclerosis. However, beyond its application at the end of life, little is known about the role of palliative care in Huntington disease.Methods In this article, we discuss what is known about palliative care in Huntington disease, specifically related to early disease burden, caregiver burnout, advance care planning, and end of life care.Results We provide a review of the current literature and discuss our own care practices.Discussion We conclude by discussing questions that remain unanswered and positing ideas for future work in the field.

  3. Did the "Woman in the Attic" in Jane Eyre Have Huntington Disease?

    Directory of Open Access Journals (Sweden)

    Elizabeth A. Coon

    2015-07-01

    Full Text Available Background: References to neurologic disorders are frequently found in fictional literature and may precede description in the medical literature. Aim: Our aim was to compare Charlotte Brontë’s depiction of Bertha Mason in Jane Eyre to the tenets set forth in George Huntington’s original essay “On chorea” with the hypothesis that Mason was displaying features of Huntington disease. Results: Charlotte Brontë’s 1847 Victorian novel Jane Eyre features the character Bertha Mason, who is portrayed with a progressive psychiatric illness, violent movements, and possible cognitive decline. Similar to Huntington’s tenets, Mason has a disorder with a strong family history suggestive of autosomal dominant inheritance with onset in adulthood, and culminating in suicide. Conclusion: Brontë’s character had features of Huntington disease as originally described by Huntington. Brontë’s keen characterization may have increased awareness of treatment of neuropsychiatric patients in the Victorian era.

  4. Special issue dedicated to Professor Johann M. Schepers

    Directory of Open Access Journals (Sweden)

    Gideon P De Bruin

    2006-10-01

    Full Text Available It is a great pleasure for me to have been associated with this special issue of the SA Journal of Industrial Psychology dedicated to Professor Johann M. Schepers. The purpose of the special issue is to honour Professor Schepers for his contributions to the development of Psychology and Industrial Psychology as empirical fields of study in South Africa. The contributors have worked with Professor Schepers as students or colleagues and share his academic interests. The articles reflect his areas of interest and employ analytic techniques taught and championed by him. We are grateful to Professor Schepers for his cooperation throughout this project. Thanks are due to all the contributors and referees.

  5. Professor Anne Khademian named National Academy of Public Administration Fellow

    OpenAIRE

    Chadwick, Heather Riley

    2009-01-01

    Anne Khademian, professor with Virginia Tech's Center for Public Administration and Policy, School of Public and International Affairs, at the Alexandria, Va., campus has been elected a National Academy of Public Administration (NAPA) Fellow.

  6. Afetividade entre professor e aluno no processo ensino-aprendizagem

    Directory of Open Access Journals (Sweden)

    Jéssica Simone Galdino Schaefer

    2015-06-01

    Full Text Available Este artigo tem como objetivo analisar as relações de afetividade entre professor e aluno no processo ensino-aprendizagem. Utiliza de metodologia com abordagem qualitativa, observação participante, e entrevistas semi-estruturadas. O lócus da pesquisa foi a Escola Municipal de Educação Básica Lizamara Aparecida Oliva de Almeida em Sinop, entre Fevereiro e Maio de 2014. Enquanto sujeitos, contou-se com professores e alunos do 3º ano do Ensino Fundamental. Dos resultados parciais, verificou-se que mesmo que a afetividade e a aprendizagem sejam reconhecidas teoricamente por Henri Wallon como elos fundamentais para o processo ensino-aprendizagem, ainda não é bem compreendido pelos sujeitos professores. Palavras-chave: psicologia educacional; afetividade; professores e alunos. 

  7. University Pedagogy for Assistant Professors at Aalborg University (Part 1)

    DEFF Research Database (Denmark)

    Kolmos, Anette; Krogh, Lone

    2003-01-01

    The article describes a course for assistant professors within the University Teacher Education at Aalborg University. The course focus is to develop knowledge, skills and methods from within the didactic, pedagogical, and learning theory-based fields....

  8. 26 CFR 509.115 - Visiting professors or teachers.

    Science.gov (United States)

    2010-04-01

    ...) REGULATIONS UNDER TAX CONVENTIONS SWITZERLAND General Income Tax § 509.115 Visiting professors or teachers. (a... not exceeding two years at any university, college, school, or other educational institution situated...

  9. Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis.

    Science.gov (United States)

    Long, Jeffrey D; Mills, James A; Leavitt, Blair R; Durr, Alexandra; Roos, Raymund A; Stout, Julie C; Reilmann, Ralf; Landwehrmeyer, Bernhard; Gregory, Sarah; Scahill, Rachael I; Langbehn, Douglas R; Tabrizi, Sarah J

    2017-11-01

    Predictive genetic testing in Huntington disease (HD) enables therapeutic trials in HTT gene expansion mutation carriers prior to a motor diagnosis. Progression-free survival (PFS) is the composite of a motor diagnosis or a progression event, whichever comes first. To determine if PFS provides feasible sample sizes for trials with mutation carriers who have not yet received a motor diagnosis. This study uses data from the 2-phase, longitudinal cohort studies called Track and from a longitudinal cohort study called the Cooperative Huntington Observational Research Trial (COHORT). Track had 167 prediagnosis mutation carriers and 156 noncarriers, whereas COHORT had 366 prediagnosis mutation carriers and noncarriers. Track studies were conducted at 4 sites in 4 countries (Canada, France, England, and the Netherlands) from which data were collected from January 17, 2008, through November 17, 2014. The COHORT was conducted at 38 sites in 3 countries (Australia, Canada, and the United States) from which data were collected from February 14, 2006, through December 31, 2009. Results from the Track data were externally validated with data from the COHORT. The required sample size was estimated for a 2-arm prediagnosis clinical trial. Data analysis took place from May 1, 2016, to June 10, 2017. The primary end point is PFS. Huntington disease progression events are defined for the Unified Huntington's Disease Rating Scale total motor score, total functional capacity, symbol digit modalities test, and Stroop word test. Of Track's 167 prediagnosis mutation carriers, 93 (55.6%) were women, and the mean (SD) age was 40.06 (8.92) years; of the 156 noncarriers, 87 (55.7%) were women, and the mean (SD) age was 45.58 (10.30) years. Of the 366 COHORT participants, 229 (62.5%) were women and the mean (SD) age was 42.21 (12.48) years. The PFS curves of the Track mutation carriers showed good external validity with the COHORT mutation carriers after adjusting for initial progression. For

  10. Ellen Gleditsch: Professor, radiochemist and mentor

    International Nuclear Information System (INIS)

    Lykknes, Annette

    2005-06-01

    This dissertation deals with Ellen Gleditsch and some important aspects of her career, as professor, radiochemist and mentor. As Professor Gleditsch supervised students, gave lectures, disseminated science, did research and administrative work; together with many others she participated in the shaping of a research university which developed during her career. She also experienced the daily life in an institute in which there was competition for both resources and positions, included the professorship she was finally granted after many set-backs. The Radiochemist Ellen Gleditsch worked and researched at Marie Curie's laboratory in Paris, and later at Bertram Boltwood's laboratory in New Haven and Stefan Meyer's Institute for Radium Research in Vienna, furthermore she planned and made efforts to establish a similar laboratory in Oslo. During her time in Paris and U.S.A. Gleditsch participated in important debates in the early period of radioactivity, including those on the determination of the radium-uranium ratio and the half-life of radium. In Norway she devoted her time to atomic weight determinations, age determinations, and radiogeological investigations. Research was all important part of Gleditsch's life and career. Gleditsch was also a Mentor in many respects; in tile international radioactivity community, as one of the first female academics and radiochcmists in Norway, for her many students, and this role seems also to have been hers within her family. In Paris she looked after students from all over the world to help alleviate their home sickness, at the University of Oslo she was known as the scientific mother to many; mentoring was among Gleditsch's main qualities. The story of Ellen Gleditsch opens for several perspectives that are discussed. 3 papers are included. In paper 1, ''Ellen Gleditsch: Pioneer Woman in Radiochemistry'', the story is about the young chemist Ellen Gleditsch, who arrived in Paris in 1907 and started cooperating with Marie Curie

  11. Percepções e atitudes de professores de escolas públicas e privadas perante o tema drogas

    Directory of Open Access Journals (Sweden)

    Tatiana Cristina Diniz Ferreira

    2010-09-01

    Full Text Available No Brasil, apesar de os professores serem considerados como agentes potenciais para a prevenção do uso de drogas, há mais de duas décadas os programas escolares de prevenção não têm alcançado os resultados esperados. Com o intuito de auxiliar a identificação da origem do problema, foram avaliadas as percepções/ atitudes de professores sobre o tema. Participaram da pesquisa vinte professores do Ensino Fundamental e Médio da cidade de São Paulo, com os quais foram realizadas entrevistas semiestruturadas. Embora esses profissionais se reconheçam como formadores de opinião, não se consideram suficientemente habilitados para tratar do tema com seus alunos, seja pela sua falta de informação, interesse ou habilidade para abordar o assunto. Quanto à informação sobre o tema, verificou-se haver uma baixa percepção sobre o risco associado às drogas lícitas. Perante estes resultados, sugere-se que os programas de prevenção destinados ao ambiente escolar sejam revistos e tenham a participação de profissionais especializados.

  12. Percepções e atitudes de professores de escolas públicas e privadas perante o tema drogas

    Directory of Open Access Journals (Sweden)

    Tatiana Cristina Diniz Ferreira

    Full Text Available No Brasil, apesar de os professores serem considerados como agentes potenciais para a prevenção do uso de drogas, há mais de duas décadas os programas escolares de prevenção não têm alcançado os resultados esperados. Com o intuito de auxiliar a identificação da origem do problema, foram avaliadas as percepções/ atitudes de professores sobre o tema. Participaram da pesquisa vinte professores do Ensino Fundamental e Médio da cidade de São Paulo, com os quais foram realizadas entrevistas semiestruturadas. Embora esses profissionais se reconheçam como formadores de opinião, não se consideram suficientemente habilitados para tratar do tema com seus alunos, seja pela sua falta de informação, interesse ou habilidade para abordar o assunto. Quanto à informação sobre o tema, verificou-se haver uma baixa percepção sobre o risco associado às drogas lícitas. Perante estes resultados, sugere-se que os programas de prevenção destinados ao ambiente escolar sejam revistos e tenham a participação de profissionais especializados.

  13. Considerações a respeito do uso exclusivo de língua-alvo em curso livre: perspectiva dos professores = Considerations towards the exclusive use of the target language in an english course: teachers’ perspectives

    Directory of Open Access Journals (Sweden)

    Kobielski, Natalie Leal

    2010-01-01

    Full Text Available O presente artigo enfoca a perspectiva dos professores de um curso livre que tem como um dos princípios o uso exclusivo da língua-alvo. A partir de uma fundamentação teórica que discute o papel da L1 em diferentes tipos de métodos e abordagens de ensino, que têm por base diferentes teorias de aquisição de linguagem, foi possível discutir sobre as motivações, vantagens e desvantagens do uso da L1 apontadas pelos professores, bem como a coerência entre tais fatores e o que acontece em sala de aula, em suas práticas de ensino. Questionários escritos e gravações de áudio das aulas dos professores constituíram os instrumentos para a coleta dos dados. Por meio deste estudo, foi possível constatar que não somente o bom senso dos professores com relação ao uso exclusivo da língua-alvo é fundamental, mas também que não é possível classificar a prática dos profissionais sob uma única concepção de aquisição de linguagem, ao ser considerada a relação entre teoria e prática dos professores

  14. Seniorforsker Ole Hertel udnævnt til adjungeret professor

    DEFF Research Database (Denmark)

    Pedersen, Jens Christian

    2009-01-01

    Sektionsleder og seniorforsker Ole Hertel, Danmarks Miljøundersøgelser (DMU) ved Aarhus Universitet, er udnævnt til adjungeret professor ved Institut for Miljø, Samfund og Rumlig Forandring på Roskilde Universitet.......Sektionsleder og seniorforsker Ole Hertel, Danmarks Miljøundersøgelser (DMU) ved Aarhus Universitet, er udnævnt til adjungeret professor ved Institut for Miljø, Samfund og Rumlig Forandring på Roskilde Universitet....

  15. Relações educacionais: comportamentos do professor de inglês que afetam a motivação do aluno

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    Girlane Moura Hickmann

    2015-10-01

    Full Text Available Este artigo é um recorte de uma pesquisa realizada em Curitiba (PR com 82 alunos e quatro professores de uma escola de línguas ligada a uma universidade publica federal. Partiu-se do pressuposto de que os comportamentos dos professores, ao ministrar suas aulas, poderiam influenciar positiva ou negativamente em algumas variáveis motivacionais dos alunos durante as aulas. O estudo teve como objetivo avaliar o estado e as metas motivacionais do aprendiz e relacionar esses elementos com a forma como os professores conduzem suas aulas. Os dados foram levantados através de entrevistas, aplicação de questionários e da observação direta dos comportamentos emitidos em sala de aula. As análises estatísticas dos dados feitas através dos testes não paramétricos de Kruskal-Wallis e Tukey apontaram para os seguintes resultados: 1 Quanto maior era a responsividade do professor maiores eram a Atitude positiva dos alunos em relação ao curso e a Adoção de Metas de Aprendizagem Orientadas tanto para o Desempenho Pessoal como pelo Meio; 2 Quanto mais estratégias aversivas o professor usava em sala de aula maior era a Adoção de Metas de Aprendizagem Orientadas para o Desempenho Pessoal; 3 Quanto maior é a Exigência e o Controle Aversivo, mais ansioso ficou o aluno.

  16. Efeito de ação educativa participativa no conhecimento de professores do ensino básico sobre malária

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    Martha Cecilia Suárez-Mutis

    2011-10-01

    Full Text Available OBJETIVO: Descrever uma estratégia educativa participativa de construção de conhecimentos relacionados à malária entre professores em um município altamente endêmico. MÉTODOS: Foi feito um estudo observacional. Um curso de 40 horas foi realizado sob enfoque multidisciplinar e problematizador para 46 professores, prioritariamente da área rural, no município de Barcelos, AM, em 2008. O processo educativo participativo incluiu oficinas e aulas práticas. Para investigar os conhecimentos, aplicou-se um questionário previamente validado, antes e após o curso, avaliado por abordagens quantitativa e qualitativa usando a análise temática para respostas abertas. RESULTADOS: Previamente ao curso, os professores tinham pouca informação sobre os mecanismos de transmissão, meios de prevenção e a associação da malária aos seus vetores, bem como conceitos restritos sobre saúde. Após o curso, não somente aumentou o conhecimento dos professores sobre a malária como também emergiram reflexões sobre o papel do professor na sociedade. CONCLUSÕES: O efeito da ação educativa na construção de um saber contextualizado sobre malária e saúde indica o potencial da estratégia desenvolvida. Processos de educação permanente são necessários à sustentabilidade dos novos saberes e práticas, orientados pela promoção da saúde.

  17. As pesquisas sobre professores iniciantes: algumas aproximações Researches about inexperienced teachers: some approaches

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    Silmara de Oliveira Gomes Papi

    2010-12-01

    Full Text Available O presente texto tem como foco as investigações sobre professores iniciantes e faz um balanço do tema a partir de pesquisas realizadas no Brasil, tendo em vista a atual tendência dos estudos sobre essa etapa do desenvolvimento profissional do professor. Para tanto, são analisados os trabalhos apresentados nas reuniões da ANPEd, nos anos de 2005, 2006 e 2007, e as pesquisas disponíveis no banco de teses da CAPES - 2000 a 2007 (mestrado e doutorado. Também é analisada a pesquisa de Brzezinski (2006, em que foi apresentado o estado do conhecimento sobre a formação de profissionais da educação. O estudo evidencia que a maioria das pesquisas analisa o professor, focando sua prática pedagógica, a construção de sua identidade, a socialização profissional e as dificuldades encontradas. Demonstra também a quase inexistência de ações de formação para esses professores e a necessidade das pesquisas brasileiras se dedicarem mais ao tema, que é pouco explorado, se considerada a relevância dessa etapa profissional.The following text focuses on the investigation into "Inexperienced Teachers" and ponders on the theme based on researches conducted in Brazil, regarding current trends about this stage of the teacher's professional development. In order to accomplish this objective, we analyzed the work presented at the ANPEd meetings in the years of 2005, 2006 and 2007 and the researches available at the CAPES Thesis Bank from 2000 to 2007 (for mastering and doctorate degrees. The research carried out by Brzezinski (2006 was also taken as an object of analysis In this research, the state of knowledge on the development of professionals working with education was presented. The study reveals that most of the researchers analyzed the teachers, focusing on their pedagogic practice, identity construction, and professional socialization, as well as on the difficulties found. It also demonstrates the nearly inexistence of development actions

  18. Professor facilitador e inibidor da criatividade segundo universitários The teacher who facilitates or inhibits creativity according to undergraduates

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    Tales Vilela Santeiro

    2004-04-01

    Full Text Available Diante do reduzido número de pesquisas relacionando criatividade ao contexto universitário brasileiro, objetiva-se caracterizar o professor facilitador e o inibidor da criatividade, segundo opinião de calouros de Biomedicina (N=117 de uma universidade particular do Nordeste Paulista. Utiliza-se como instrumento um questionário com duas perguntas abertas, focalizando características do professor que facilita e do que inibe a criatividade dos alunos. As respostas foram avaliadas por categorias e por correlação de julgamentos de dois juízes. Os dados foram tratados quantitativamente (cálculos descritivos e Qui-quadrado. As características facilitadoras da criatividade foram relacionadas ao preparo do professor e as inibidoras foram referentes ao modo como o professor se relaciona com os alunos.In view of the reduced amount of researches relating creativity and the Brazilian university context, this work aims to characterize the teachers who facilitate and the ones who inhibit creativity according to the opinion of freshmen in Biomedicine (N=117 from private universities in the northeastern area of São Paulo state. It uses, as instrument, a two-question questionnaire focusing on the teacher’s characteristics that facilitate or inhibit the students’ creativity. The answers were assessed by categories and by the co-relation of two judges’ analyses. The data were quantitatively approached (descriptive calculus and Chi-square test. The creativity facilitating characteristics were associated to the teachers’ professional skills and the inhibiting ones refer to the teachers’ relationship with students.

  19. Um estudo acerca dos cursos de formação de professores de língua estrangeira e o paradigma contemporâneo

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    Enrique Huelva UNTERNBÄUMEN

    2011-07-01

    Full Text Available Este artigo descreve uma pesquisa que investigou três cursos de Licenciatura em Língua Estrangeira (espanhola, francesa e inglesa em uma universidade federal do Brasil, quanto a se estão, de fato, preparando os professores para a prática docente em conformidade com os parâmetros teóricos contemporâneos. De cada curso, colaboraram três professoras em formação cursando o último semestre e uma professora formadora, perfazendo um total de 12 participantes. Foram usados questionários abertos com questões sobre o curso, as disciplinas e conhecimentos considerados necessários ao professor em formação. Os resultados sugerem que os cursos investigados têm sua base mais próxima do paradigma estruturalista que do paradigma comunicativo contemporâneo. As participações sugerem que a base teórica oferecida aos professores em formação não mostra ser completamente consistente com os fundamentos para o ensino de línguas comunicativo. Desta forma, identificam-se lacunas na estrutura dos cursos investigados as quais demandam correção para chegarmos a uma formação de professores de línguas que vá ao encontro de toda a produção teórica já disponível para essa tarefa.

  20. Os saberes dos professores-referência no ensino de contabilidade

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    Gilberto José Miranda

    2012-08-01

    Full Text Available O presente estudo tem como propósito avaliar os saberes predominantes nos docentes percebidos como professores-referência pelos alunos de um curso de Graduação em Ciências Contábeis de uma universidade pública brasileira. O estudo justifica-se pelas recentes e significativas mudanças no contexto da Contabilidade no Brasil. Para alcance desse propósito, estruturou-se uma pesquisa qualitativa, em que foram utilizadas as seguintes estratégias de pesquisa e técnicas de coleta de dados: (i pesquisa bibliográfica em obras relevantes que tratam do tema; (ii pesquisa documental nas avaliações dos professores feitas pela instituição; (iii questionários aplicados aos alunos do último ano; (iv grupo focal com parte do grupo de alunos respondentes dos questionários; e (v entrevista semiestruturada com professores apontados pelos alunos como docentes de referência. Amparados pelas discussões tecidas acerca de saberes, competências e conhecimentos necessários à docência (Shulman, 1986; Garcia, 1992; Freire, 2000; Pimenta, 1998; Pimenta & Anastasiou, 2002; Gauthier, Martineau, Desbiens, Malo, & Simard, 1998; Tardif, 2003; Cunha, 2004; Masetto, 1998; Braslavsky, 1999; Perrenoud, 2000; Zabalza, 2006 e aqueles necessários ao ensino de contabilidade (Antonelli, Colauto, & Cunha, 2012; Miranda, 2011; Catapan, Colauto, & Sillas, 2011; Vasconcelos, 2010; Slomsky, 2009; Araujo & Santana, 2008; Celerino & Pereira, 2008; Andere & Araújo, 2008; Laffin, 2005, bem como pesquisas sobre professores exemplares (Young & Shaw, 1999; Lowman, 2007, verificaram-se os seguintes resultados: as disciplinas responsáveis pelas experiências mais significativas de aprendizagem, durante o curso, eram as percebidas como base do curso (Contabilidade Básica, Intermediária e Avançada e que apresentavam maior aplicação prática. As razões principais para escolha dos docentes de referência foram: didática ou metodologia de ensino, atitudes e qualidades

  1. Compreendendo o que é ser um professor reflexivo ante a ação pedagógica

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    Gabriela Selingardi

    2017-12-01

    Full Text Available Ao ensinar, o docente esbarra em várias dificuldades. Entre elas, a dificuldade de aprendizagem dos alunos, a gestão do tempo e do currículo escolar, entre outros. A racionalidade prático-reflexiva, trazida por Schön, propõe uma reflexão crítica e intencional proveniente da prática e da ação do professor ao se deparar, com as incertezas do ambiente escolar. Assim, esse modelo propõe que o professor deverá observar e refletir sobre suas ações e ocorrências em sala de aula, para poder resolver os problemas encontrados. Portanto, a presente pesquisa visa analisar a minha prática avaliativa, durante as aulas de regência realizadas em uma Escola Pública. Este trabalho se apoia nas teorias sobre professor reflexivo dos teóricos: Selma Garrido Pimenta e Donald A. Schön. A coleta de dados foi realizada por meio das narrativas confeccionadas pela própria estagiária autora deste artigo, durante a disciplina de Estágio Supervisionado II. Por fim, procurou-se elementos que respondessem a problemática central da pesquisa, a saber: “Como as ações pedagógicas de uma estagiária contribuíram para reflexão da sua própria prática? ” Por meio da pesquisa foi possível observar que a estagiária ao longo da sua prática no estágio não refletiu em todos os momentos, mas, por outro lado, notou a evolução da estagiária, que se mostrou preocupada com os alunos, tentando melhorar sua prática em sala de aula. Quando o professor reflete, ele busca formas de solucionar os problemas com que depara e (redirecionar a sua prática. Dessa forma, notou-se uma evolução na atitude da estagiária, que refletiu criticamente sobre sua prática em diversos momentos.

  2. A representação social do “bom professor” no ensino superior

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    Cássia Marques Cândido

    2014-08-01

    Full Text Available O estudo investiga as Representações Sociais de alunos de uma Universidade Federal do Rio de Janeiro sobre o "bom professor". O interesse pelo fenômeno surgiu pela constatação de urgência na promoção de ações que contribuam para melhoria do Ensino Superior, assim como pela escassez de estudos que tratem do processo ensino aprendizagem no contexto do Ensino Superior, sobretudo com a utilização da Teoria das Representações Sociais. A coleta de dados ocorreu através da aplicação de um questionário, abrangendo 294 estudantes de variados cursos de graduação. As categorias que emergiram do discurso dos participantes puderam ser classificadas em dois grupos: um relacionado aos aspectos técnicos da profissão docente; outro relacionado ao professor em seu processo de interação com o aluno. Os resultados permitiram refletir sobre a necessidade de atenção às especificidades inerentes à formação docente para o Ensino Superior, destacando a relevância do papel docente na formação do futuro profissional.

  3. Leitura, escola e o compromisso do professor: entre preocupações e provocações

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    Cícera Maria dos Santos

    2017-06-01

    Full Text Available Este trabalho discute a problemática que envolve o hábito da leitura na Educação Básica. Tem como objetivo discutir questões relacionadas às dificuldades de leitura bem como o papel da escola e dos professores na minimização do problema em questão. Com base em pesquisas e ensaios relevantes sobre o tema, explicita o tema a partir do conceito de leitura e sua utilização no cotidiano do aluno. Faz referência as estratégias de ensino da leitura como condição essencial ao desenvolvimento da competência leitora. Enfatiza o papel da escola enquanto instituição responsável formalmente e parcialmente pelo aprendizado cognitivo do aluno nas diferentes áreas do conhecimento, primando pela proficiência leitora. Apresenta como saída ao problema detectado o estímulo por parte da escola e desempenho de seus profissionais, em criar situações em que o aluno aprecie a importância da leitura, bem como mostrar a importância da formação contínua dos professores, a reflexão e avaliação de suas práticas pedagógicas.

  4. Network topology and functional connectivity disturbances precede the onset of Huntington's disease.

    Science.gov (United States)

    Harrington, Deborah L; Rubinov, Mikail; Durgerian, Sally; Mourany, Lyla; Reece, Christine; Koenig, Katherine; Bullmore, Ed; Long, Jeffrey D; Paulsen, Jane S; Rao, Stephen M

    2015-08-01

    Cognitive, motor and psychiatric changes in prodromal Huntington's disease have nurtured the emergent need for early interventions. Preventive clinical trials for Huntington's disease, however, are limited by a shortage of suitable measures that could serve as surrogate outcomes. Measures of intrinsic functional connectivity from resting-state functional magnetic resonance imaging are of keen interest. Yet recent studies suggest circumscribed abnormalities in resting-state functional magnetic resonance imaging connectivity in prodromal Huntington's disease, despite the spectrum of behavioural changes preceding a manifest diagnosis. The present study used two complementary analytical approaches to examine whole-brain resting-state functional magnetic resonance imaging connectivity in prodromal Huntington's disease. Network topology was studied using graph theory and simple functional connectivity amongst brain regions was explored using the network-based statistic. Participants consisted of gene-negative controls (n = 16) and prodromal Huntington's disease individuals (n = 48) with various stages of disease progression to examine the influence of disease burden on intrinsic connectivity. Graph theory analyses showed that global network interconnectivity approximated a random network topology as proximity to diagnosis neared and this was associated with decreased connectivity amongst highly-connected rich-club network hubs, which integrate processing from diverse brain regions. However, functional segregation within the global network (average clustering) was preserved. Functional segregation was also largely maintained at the local level, except for the notable decrease in the diversity of anterior insula intermodular-interconnections (participation coefficient), irrespective of disease burden. In contrast, network-based statistic analyses revealed patterns of weakened frontostriatal connections and strengthened frontal-posterior connections that evolved as disease

  5. DISCOURSE SPACE OF THE LINGUOCULTURAL CHARACTER TYPE PROFESSOR

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    Lara Sinelnikova

    2014-10-01

    Full Text Available The article offers an analysis of the linguocultural character type professor taking into consideration both traditional set of signs and those transformations that indicate accumulation of evolutionary changes. The methodological base for the systematic description were the achievements of such areas of scientific knowledge as personology, linguopersonology and discourseology. The linguocultural character type (LCCT is a generalised image of persons, whose behaviour and value orientations influence culture, language and show social originality of the society. The peculiarity of the studied linguocultural character type is in its interrelation with the linguocultural character types intellectual and teacher as well as in the fact of the traditional connection with the concept elite. The exposure of such kind of multidimensional relations allowed to focus attention on the qualities of the LCCT professor that ensure its relative self-sufficiency. The sign of elitism and belonging to the intellectuals of the LCCT professor is asserted by the high social status recognised by the society, which is based on professionalism and compliance with moral principles. The axiological generality of the LCCT professor and teacher is ensured by the peculiarities of the modern pedagogical discourse with its typical image settings. One of the main features of the image of a professor is its belonging to the elite language person. The transformational processes in the contents of the LCCT professor are connected with the globalisation: including the international dimension in the evaluation of the professional activity, complication of the language environment, marketisation of the university sphere.

  6. A PERSPECTIVA SOCIOCULTURAL E A FORMAÇÃO DE PROFESSORES DE LÍNGUAS

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    Ana Cristina Biondo Salomão

    2013-12-01

    Full Text Available Este artigo pretende traçar um histórico do desenvolvimento da formação de professores de línguas no Brasil e no exterior, assim como discutir os postulados da perspectiva sociocultural, de Vygotsky, como base teórica na qual a formação pode se ancorar na contemporaneidade. Uma vez que aprender a ensinar hoje é entendido como um processo longo e complexo de desenvolvimento, resultado da participação em práticas sociais e contextos associados ao ensino e aprendizagem, pretendemos discutir de que modo tal perspectiva teórica vem ao encontro de uma visão interpretativista da realidade e propicia elementos para a (reconstrução e transformação das práticas docentes, colocando o conhecimento como íntima e dinamicamente ligado à experiência e destacando o papel do agenciamento humano em seu próprio desenvolvimento.

  7. A PERSPECTIVA SOCIOCULTURAL E A FORMAÇÃO DE PROFESSORES DE LÍNGUAS

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    Ana Cristina Biondo Salomão

    2014-05-01

    Full Text Available Este artigo pretende traçar um histórico do desenvolvimento da formação de professores de línguas no Brasil e no exterior, assim como discutir os postulados da perspectiva sociocultural, de Vygotsky, como base teórica na qual a formação pode se ancorar na contemporaneidade. Uma vez que aprender a ensinar hoje é entendido como um processo longo e complexo de desenvolvimento, resultado da participação em práticas sociais e contextos associados ao ensino e aprendizagem, pretendemos discutir de que modo tal perspectiva teórica vem ao encontro de uma visão interpretativista da realidade e propicia elementos para a (reconstrução e transformação das práticas docentes, colocando o conhecimento como íntima e dinamicamente ligado à experiência e destacando o papel do agenciamento humano em seu próprio desenvolvimento.

  8. A randomized, double-blind, placebo-controlled study of latrepirdine in patients with mild to moderate Huntington disease

    DEFF Research Database (Denmark)

    Hjermind, Lena Elisabeth

    2013-01-01

    BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease. OBJECTIVE To determine the effect of latrepir......BACKGROUND Latrepirdine is an orally administered experimental small molecule that was initially developed as an antihistamine and subsequently was shown to stabilize mitochondrial membranes and function, which might be impaired in Huntington disease. OBJECTIVE To determine the effect...... of latrepirdine on cognition and global function in patients with mild to moderate Huntington disease. DESIGN Randomized, double-blind, placebo-controlled study. SETTING Sixty-four research centers in Australia, Europe, and North America. PATIENTS Four hundred three patients with mild to moderate Huntington...... between those randomized to latrepirdine (68.5%) and placebo (68.0%). CONCLUSION In patients with mild to moderate Huntington disease and cognitive impairment, treatment with latrepirdine for 6 months was safe and well tolerated but did not improve cognition or global function relative to placebo. TRIAL...

  9. Forecasting the Student-Professor Matches That Result in Unusually Effective Teaching

    Science.gov (United States)

    Gross, Jennifer; Lakey, Brian; Lucas, Jessica L.; LaCross, Ryan; Plotkowski, Andrea R.; Winegard, Bo

    2015-01-01

    Background: Two important influences on students' evaluations of teaching are relationship and professor effects. Relationship effects reflect unique matches between students and professors such that some professors are unusually effective for some students, but not for others. Professor effects reflect inter-rater agreement that some professors…

  10. "They Are Weighted with Authority": Fat Female Professors in Academic and Popular Cultures

    Science.gov (United States)

    Fisanick, Christina

    2007-01-01

    The images of fat professors encountered in popular culture are few in number and negative in depiction. In this article, the author discusses on how will the professorial body affect the way in which students perceive the professor's teaching abilities. The author concludes that bias against fat professors, professors of color, and other…

  11. O professor que cativa: entre a narrativa da história e o cuidado de si

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    Marcello Paniz Giacomoni

    2016-03-01

    Full Text Available O presente artigo apresenta e discute os primeiros passos da pesquisa “Ensino de História e narrativas: o professor e a persuasão em sala de aula”, desenvolvida no Programa de Pós Graduação de Educação da UFRGS, em nível de doutorado, sob orientação do Prof. Dr. Fernando Seffner. Partindo de uma reflexão sobre o Ensino de História e analisando o caráter narrativo da história, passando por autores como Hayden White, Peter Gay, Jörn Rüsen, Paul Ricoeur, e Walter Benjamin, desejamos compreender quais estratégias são utilizadas pelos professores na construção de suas aulas. Interessa-nos compreender quais elementos narrativos e de estilo compõem um discurso histórico capaz de obter a adesão do auditório escolar, a partir de referenciais da Nova Retórica. Nessa análise, o que propomos é uma arte, relacionando a narrativa com a criação subjetiva e a experiência vivida (no caso, a experiência histórica, compreendendo como os professores de História elaboram o conhecimento historiográfico em suas aulas. Essa elaboração visa a negociar a distância entre o tempo passado e o momento do aluno, gerando momentos de encantamento ao poder da palavra. Ensino de História, professores,narrativas,estilo,nova retórica,

  12. Avaliação de ações de combate ao desemprego adotadas em dois municípios da Grande Florianópolis

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    Leonardo Secchi

    1999-01-01

    Full Text Available O principal objetivo desta pesquisa foi realizar uma avaliação das ações adotadas pelo poder público, instituições privadas e não governamentais, com vista ao combate de desemprego em dois municípios da grande Florianópolis. Além deste objetivo, a pesquisa realizou um mapeamento da situação atual do mercado de trabalho e aponta os principais motivos que geram desemprego nestes municípios. O estudo utilizou o método exploratório/descritivo de coleta de dados. O levantamento de tais dados foi feito junto aos postos do SINE dos municípios, IBGE, Comissões Municipais de Trabalho e Emprego, instituições de combate ao desemprego e professores e pesquisadores da UFSC. Finalmente, foram adequadas propostas de combate ao desemprego às realidades daslocalidades investigadas.

  13. Customer satisfaction and response to AOS

    Science.gov (United States)

    1999-01-01

    Passenger surveys were conducted in each of three successive springs in order to track passenger perception of changes in service quality during AOS implementation. In general, no improvement in passenger perceptions was observed relative to a high b...

  14. A Representação Cultural da Deficiência nos Discursos Midiáticos do Portal do Professor do MEC1

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    Ana Flávia Teodoro de Mendonça OLIVEIRA

    2016-03-01

    Full Text Available RESUMO: na presente pesquisa, objetivamos investigar a representação cultural da deficiência nos discursos midiáticos do Portal do Professor do Ministério da Educação (MEC, buscando identificar os estereótipos e as possíveis essencializações existentes na produção dos sujeitos com deficiência. Nossa análise fundamentou-se na perspectiva foucaultiana de análise arqueológica do discurso, portanto, elegemos como arquivo um conjunto de documentos que vão desde aulas produzidas no Espaço da aula, passando por publicações no Jornal do professor, nos quais se encontram artigos ligados à deficiência, por discursos de profissionais da educação, veiculados nos vídeos institucionais, até músicas, artigos de revistas, histórias em quadrinhos (HQs, vídeos do youtube, textos da literatura infantil, dentre outros. Os achados da pesquisa revelam que, embora o discurso do Portal atraia os professores pelas possibilidades de intervenção, de transformação que oferece, apesar do conjunto heterogêneo de técnicas que utiliza, conquanto seja subsidiado pelo Ministério da Educação, continua persistindo na produção da deficiência de uma maneira pejorativa e estereotipada. Assim, o Portal do Professor do MEC, ao colocar ao dispor dos professores metodologias variadas, ao mostrar as condutas desejáveis, ao prescrever práticas pedagógicas que cumpram as metas educacionais propostas pelo Estado Brasileiro, para educação das pessoas com deficiência, numa perspectiva inclusiva, pode acabar produzindo um efeito contrário, tendo em vista que muito do que é proposto nesse espaço formativo está atrelado a uma concepção de educação normalizadora e patologizante, contrariando os pressupostos básicos de uma educação inclusiva.

  15. A formação contínua do professor-formador: constituição dos saberes profissionais em processos reflexivos coletivos

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    Ademar Antonio Lauxen

    2017-08-01

    Full Text Available The objective of the research that motivated this article is to discuss the knowledge that characterize the teacher as well as the attributes related to teacher-educator and its relevance to the constitution of critical and reflective professional. This is a qualitative character study, in the perspective of investigation-action, resulting from interviews with semi-structured questions, conducted with ten teachers-educators, acting in the chemistry teaching degree course. The research reveals attributes and characteristics inherent in a good teacher and which associate with the teacher-educator, discussing how the interviewed correlate those two categories. Besides, it points to the necessity of reflective processes by the educator, signaling to this reflection to be able to break with the purely individual process and constitute in a collective social practice in intra-institutional space/time. The data also reveal that the teachers-educator have points of convergence with knowledge for teaching, and that those to be revealed and problematized in spaces/times the continuous training can contribute to a better understanding of the teacher's being and doing. O objetivo da pesquisa que motivou este artigo é discutir os saberes que caracterizam o educador, bem como os atributos relacionados ao professor-formador e sua pertinência para a constituição do profissional crítico-reflexivo. Este estudo é de caráter qualitativo, na perspectiva da investigação-ação, resultado de entrevista com questões semiestruturadas, realizadas com dez professores-formadores, atuantes em um curso de licenciatura em Química. A pesquisa revela atributos e características inerentes ao bom professor e que se associam ao professor-formador, discutindo como os entrevistados correlacionam essas duas categorias. Além disso, aponta para a necessidade de processos reflexivos por parte do educador, sinalizando que essa reflexão pode romper com o processo meramente

  16. Construção de instrumentos teórico-metodológicos para captar a formação de professores

    Directory of Open Access Journals (Sweden)

    Daniela Gonçalves de Abreu

    2014-06-01

    Full Text Available A pesquisa sobre o perfil do educador ambiental tem exigido uma metodologia de investigação adequada para a captação de seu processo de formação. Dado que ao pesquisar a formação de professores estamos diante de algo que não está posto materialmente e tem caráter dinâmico, de que modo tomar a formação do educador ambiental como objeto de pesquisa? Para a construção de uma resposta a essa pergunta, o presente trabalho requereu instrumentos teóricos e metodológicos que possibilitassem apreender a formação do professor em sua atividade educativa. A formação do educador ambiental pressupõe um ambiente em que todos tenham voz e possam trocar experiências, rever seus conhecimentos e produzir novos sentidos a partir de uma perspectiva crítica. A constituição de uma comunidade de aprendizagem numa escola pública estabeleceu um contexto propício para a formação dos professores. Pudemos comprovar que o Horário de Trabalho Pedagógico Coletivo, quando planejado e organizado, pode intencionalmente contribuir para a formação de professores. A teoria da atividade nos forneceu subsídios tanto do ponto de vista de ensino, ao proporcionar embasamento para a organização de encontros com professores de ensino médio, sempre levando em conta a intencionalidade da formação, quanto do ponto de vista metodológico, ao possibilitar a apreensão de nosso objeto, ou seja, o processo de formação em seu movimento. Na interação entre os sujeitos, foi possível a ampliação de seus pontos de vista e a ocorrência de mudanças de sentidos relacionados a temas ambientais. Um sujeito, ao evocar um pensamento, uma reflexão, possibilita que os demais revisitem seus posicionamentos e conhecimentos. Assim, formam-se conhecimentos - e, consequententemente, indivíduos - com qualidade nova.

  17. A qualidade do sono, o aproveitamento escolar e o stress em adolescentes que permacem em frente ao computador durante a noite

    OpenAIRE

    Gema Galgani de Mesquita Duarte

    2007-01-01

    Resumo: A qualidade do sono, o aproveitamento escolar e o stress em adolescentes que permanecem em frente ao computador durante a noite. 2007. 234p. Professor Doutor Rubens Nelson Amaral de Assis Reimão. Dissertação (Mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento da Saúde da Criança e do Adolescente. INTRODUÇÃO: O sono representa importante papel na vida do homem, influenciando as condições físicas, psicológicas e sociais. Está intimamente ligado ao...

  18. Polysomnographic Findings and Clinical Correlates in Huntington Disease: A Cross-Sectional Cohort Study

    Science.gov (United States)

    Piano, Carla; Losurdo, Anna; Della Marca, Giacomo; Solito, Marcella; Calandra-Buonaura, Giovanna; Provini, Federica; Bentivoglio, Anna Rita; Cortelli, Pietro

    2015-01-01

    Study Objectives: To evaluate the sleep pattern and the motor activity during sleep in a cohort of patients affected by Huntington disease (HD). Design: Cross-sectional cohort study. Setting: Sleep laboratory. Patients: Thirty HD patients, 16 women and 14 men (mean age 57.3 ± 12.2 y); 30 matched healthy controls (mean age 56.5 ± 11.8 y). Interventions: Subjective sleep evaluation: Epworth Sleepiness Scale (ESS); Berlin's Questionnaire, interview for restless legs syndrome (RLS), questionnaire for REM sleep behavior disorder (RBD). Clinical evaluation: disease duration, clinical severity (unified Huntington disease motor rating scale [UHDMRS]), genetic tests. Laboratory-based full-night attended video-polysomnography (V-PSG). Measurements and Results: The duration of the disease was 9.4 ± 4.4 y, UHMDRS score was 55.5 ± 23.4, CAG repeats were 44.3 ± 4.1. Body mass index was 21.9 ± 4.0 kg/m2. No patients or caregivers reported poor sleep quality. Two patients reported symptoms of RLS. Eight patients had an ESS score ≥ 9. Eight patients had high risk of obstructive sleep apnea. At the RBD questionnaire, two patients had a pathological score. HD patients, compared to controls, showed shorter sleep, reduced sleep efficiency index, and increased arousals and awakenings. Four patients presented with sleep disordered breathing (SDB). Periodic limb movements (PLMs) during wake and sleep were observed in all patients. No episode of RBD was observed in the V-PSG recordings, and no patients showed rapid eye movement (REM) sleep without atonia. The disease duration correlated with ESS score (P Marca G, Solito M, Calandra-Buonaura G, Provini F, Bentivoglio AR, Cortelli P. Polysomnographic findings and clinical correlates in Huntington disease: a cross-sectional cohort study. SLEEP 2015;38(9):1489–1495. PMID:25845698

  19. Nonparametric estimation for censored mixture data with application to the Cooperative Huntington's Observational Research Trial.

    Science.gov (United States)

    Wang, Yuanjia; Garcia, Tanya P; Ma, Yanyuan

    2012-01-01

    This work presents methods for estimating genotype-specific distributions from genetic epidemiology studies where the event times are subject to right censoring, the genotypes are not directly observed, and the data arise from a mixture of scientifically meaningful subpopulations. Examples of such studies include kin-cohort studies and quantitative trait locus (QTL) studies. Current methods for analyzing censored mixture data include two types of nonparametric maximum likelihood estimators (NPMLEs) which do not make parametric assumptions on the genotype-specific density functions. Although both NPMLEs are commonly used, we show that one is inefficient and the other inconsistent. To overcome these deficiencies, we propose three classes of consistent nonparametric estimators which do not assume parametric density models and are easy to implement. They are based on the inverse probability weighting (IPW), augmented IPW (AIPW), and nonparametric imputation (IMP). The AIPW achieves the efficiency bound without additional modeling assumptions. Extensive simulation experiments demonstrate satisfactory performance of these estimators even when the data are heavily censored. We apply these estimators to the Cooperative Huntington's Observational Research Trial (COHORT), and provide age-specific estimates of the effect of mutation in the Huntington gene on mortality using a sample of family members. The close approximation of the estimated non-carrier survival rates to that of the U.S. population indicates small ascertainment bias in the COHORT family sample. Our analyses underscore an elevated risk of death in Huntington gene mutation carriers compared to non-carriers for a wide age range, and suggest that the mutation equally affects survival rates in both genders. The estimated survival rates are useful in genetic counseling for providing guidelines on interpreting the risk of death associated with a positive genetic testing, and in facilitating future subjects at risk

  20. Current status of PET imaging in Huntington's disease

    International Nuclear Information System (INIS)

    Pagano, Gennaro; Niccolini, Flavia; Politis, Marios

    2016-01-01

    To review the developments of recent decades and the current status of PET molecular imaging in Huntington's disease (HD). A systematic review of PET studies in HD was performed. The MEDLINE, Web of Science, Cochrane and Scopus databases were searched for articles in all languages published up to 19 August 2015 using the major medical subject heading ''Huntington Disease'' combined with text and key words ''Huntington Disease'', ''Neuroimaging'' and ''PET''. Only peer-reviewed, primary research studies in HD patients and premanifest HD carriers, and studies in which clinical features were described in association with PET neuroimaging results, were included in this review. Reviews, case reports and nonhuman studies were excluded. A total of 54 PET studies were identified and analysed in this review. Brain metabolism ([ 18 F]FDG and [ 15 O]H 2 O), presynaptic ([ 18 F]fluorodopa, [ 11 C]β-CIT and [ 11 C]DTBZ) and postsynaptic ([ 11 C]SCH22390, [ 11 C]FLB457 and [ 11 C]raclopride) dopaminergic function, phosphodiesterases ([ 18 F]JNJ42259152, [ 18 F]MNI-659 and [ 11 C]IMA107), and adenosine ([ 18 F]CPFPX), cannabinoid ([ 18 F]MK-9470), opioid ([ 11 C]diprenorphine) and GABA ([ 11 C]flumazenil) receptors were evaluated as potential biomarkers for monitoring disease progression and for assessing the development and efficacy of novel disease-modifying drugs in premanifest HD carriers and HD patients. PET studies evaluating brain restoration and neuroprotection were also identified and described in detail. Brain metabolism, postsynaptic dopaminergic function and phosphodiesterase 10A levels were proven to be powerful in assessing disease progression. However, no single technique may be currently considered an optimal biomarker and an integrative multimodal imaging approach combining different techniques should be developed for monitoring potential neuroprotective and preventive treatment

  1. Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease

    Directory of Open Access Journals (Sweden)

    Parekh-Olmedo Hetal

    2006-10-01

    Full Text Available Abstract Background Huntington's Disease (HD is an inherited autosomal dominant genetic disorder in which neuronal tissue degenerates. The pathogenesis of the disease appears to center on the development of protein aggregates that arise initially from the misfolding of the mutant HD protein. Mutant huntingtin (Htt is produced by HD genes that contain an increased number of glutamine codons within the first exon and this expansion leads to the production of a protein that misfolds. Recent studies suggest that mutant Htt can nucleate protein aggregation and interfere with a multitude of normal cellular functions. Results As such, efforts to find a therapy for HD have focused on agents that disrupt or block the mutant Htt aggregation pathway. Here, we report that short guanosine monotonic oligonucleotides capable of adopting a G-quartet structure, are effective inhibitors of aggregation. By utilizing a biochemical/immunoblotting assay as an initial screen, we identified a 20-mer, all G-oligonucleotide (HDG as an active molecule. Subsequent testing in a cell-based assay revealed that HDG was an effective inhibitor of aggregation of a fusion protein, comprised of a mutant Htt fragment and green fluorescent protein (eGFP. Taken together, our results suggest that a monotonic G-oligonucleotide, capable of adopting a G-quartet conformation is an effective inhibitor of aggregation. This oligonucleotide can also enable cell survival in PC12 cells overexpressing a mutant Htt fragment fusion gene. Conclusion Single-stranded DNA oligonucleotides capable of forming stable G-quartets can inhibit aggregation of the mutant Htt fragment protein. This activity maybe an important part of the pathogenecity of Huntington's Disease. Our results reveal a new class of agents that could be developed as a therapeutic approach for Huntington's Disease.

  2. Implicações das tecnologias e da organização escolar no aprender matemática: o olhar do professor

    Directory of Open Access Journals (Sweden)

    Aline Cardoso de Oliveira Macedo

    2017-05-01

    Full Text Available Para grande parte dos alunos do Ensino Médio, utilizar as várias tecnologias existentes não é desafio. O desafio consiste na escolha das tecnologias que eles empregam para o aprender. Para tentar compreender essas escolhas, trazemos o presente artigo que analisa os discursos, organizados a partir de entrevistas semiestruturadas, feitas com professores de Matemática de um Instituto Federal. As perguntas versaram sobre a percepção do comprometimento de seus alunos com a sua própria aprendizagem e as tecnologias escolhidas no aprender. Para organizar as discursividades, escolhemos a técnica Discurso do Sujeito Coletivo, proposta por Fernando Lefèvre e Ana Maria Lefèvre. Ao analisarmos esses discursos, com o aporte teórico da Biologia do Conhecer desenvolvida por Humberto Maturana e Francisco Varela, compreendemos que o professor está procurando maneiras diferentes para trabalhar, visando atender às necessidades dos seus alunos, pois trabalhar pedagogicamente com a tecnologia requer apropriação da mesma. Percebemos que o comprometimento de alunos e professores é ponto de partida para que se ampliem as possibilidades de cooperação e de significados do próprio aprender Matemática. É em um ambiente cooperativo que, professores e alunos, poderão conviver e encontrar as tecnologias que mediarão esse aprender.

  3. Com a palavra o professor: o que os docentes de uma escola pública municipal têm a dizer sobre o Poder Escolar

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    Jose Mabel Pereira Lopes das Neves

    2014-07-01

    Full Text Available Este trabalho apresenta uma pesquisa que buscou, através da fala dos professores, compreender o impacto que um evento de formação causa em suas práticas. Foram entrevistados professores da rede municipal de Capão do Leão, e para tanto, a pesquisa partiu do conceito de formação e de que maneira estes professores se utilizam para realizá-la. O estudo referencia-se em autores como Tardif e Nóvoa, bem como na LDB, a qual prevê a obrigatoriedade da formação. Ao analisar as entrevistas, pode-se observar que os professores buscam por formação continuada, mesmo com os entraves que se apresentam, que eventos contribuem nas atividades de sala de aula e que a socialização destas atividades colaboram com a educação oportunizando a reflexão da prática.

  4. Bullying: conhecimentos, atitudes e crenças de professores = Bullying: teachers’ knowledge, attitudes and beliefs = Acoso: conocimientos, actitudes y creencias de profesores

    Directory of Open Access Journals (Sweden)

    Silva, Jorge Luiz da

    2014-01-01

    Full Text Available O presente estudo investigou se professores de 6º ano do Ensino Fundamental conheciam, identificavam e como intervinham nas situações de bullying ocorridas em sala de aula. Participaram seis professores e os dados foram obtidos por meio da técnica de grupo focal, em 2010. Utilizou-se a análise de conteúdo no tratamento do material coletado. Dentre os resultados, obteve-se que os professores não possuíam conhecimentos suficientes acerca das principais características deste fenômeno, bem como a respeito de sua gravidade, indicando realizarem intervenções, em sua maioria, pontuais, circunscritas aos eventos identificados e após a ocorrência desses. Também referiram sentirem-se insuficientemente preparados para identificarem e lidarem com as agressões praticadas pelos alunos. Assim sendo, depreende-se que a formação dos professores constitui um aspecto importante a ser trabalhado em programas de prevenção e intervenção sobre o bullying escolar

  5. Saúde percebida em professores universitários: gênero, religião e condições de trabalho

    Directory of Open Access Journals (Sweden)

    Kátia Bones Rocha

    Full Text Available A presente pesquisa investiga como os professores de uma universidade particular percebem sua saúde. O delineamento é de caráter descritivocorrelacional. Os instrumentos utilizados: Questionário de Saúde de Goldberg (QGS-60 e uma ficha com dados biodemográficos investigaram variáveis individuais e relativas à atividade laboral. A amostra se constituí de 161 professores, escolhidos por estratos através das diferentes área de formação. Os resultados revelam que os professores percebem que sua saúde geral está como de costume, ou seja, nem melhor nem pior e que existe associação entre as variáveis sexo, prática religiosa e variáveis relativas ao ambiente de trabalho (horas de trabalho na universidade e em sala de aula, influenciando a percepção que os professores têm de sua saúde.

  6. Psychiatric and cognitive symptoms in Huntington's disease are modified by polymorphisms in catecholamine regulating enzyme genes

    DEFF Research Database (Denmark)

    Vinther-Jensen, T; Nielsen, Troels Tolstrup; Budtz-Jørgensen, E

    2016-01-01

    Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. HD is caused by a CAG repeat expansion in the Huntingtin (HTT) gene but the exact pathogenesis remains unknown. Dopamine imbalance has......-described cohort of Danish HD gene-expansion carriers. We show that cognitive impairment and psychiatric symptoms in HD are modified by polymorphisms in the monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) genes and by the 4p16.3 B haplotype. These results support the theory of dopamine imbalance...

  7. Derivation of Huntington Disease affected Genea046 human embryonic stem cell line

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    Biljana Dumevska

    2016-03-01

    Full Text Available The Genea046 human embryonic stem cell line was derived from a donated, fully commercially consented ART blastocyst, carrying HTT gene CAG expansion of 45 repeats, indicative of Huntington Disease. Following ICM outgrowth on inactivated human feeders, karyotype was confirmed as 46, XX by CGH and STR analysis demonstrated a female Allele pattern. The hESC line had pluripotent cell morphology, 85% of cells expressed Nanog, 92% Oct4, 75% Tra1–60 and 99% SSEA4 and demonstrated Alkaline Phosphatase activity. The cell line was negative for Mycoplasma and visible contamination.

  8. El papel de la terapia ocupacional en la enfermedad de Huntington

    OpenAIRE

    Hernández Lozano, David; Fernández Hawrylak, María; Grau Rubio, Claudia

    2014-01-01

    se analiza el papel del terapeuta ocupacional en el trabajo con las personas afectadas por la enfermedad de Huntington. se realizó una investigación por objetivos a través del diseño y puesta en práctica de un programa de intervención encaminado a mitigar el deterioro producido por la enfermedad mediante el entrenamiento en actividades de la vida diaria y de estimulación cognitiva, y a desarrollar competencias en la familia. la investigación se desarrolló en la Asociación de corea de Huntingt...

  9. Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.

    Science.gov (United States)

    Sathyasaikumar, Korrapati V; Breda, Carlo; Schwarcz, Robert; Giorgini, Flaviano

    2018-01-01

    The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally.

  10. A Case of Juvenile Huntington Disease in a 6-Year-Old Boy

    Directory of Open Access Journals (Sweden)

    Jun-Sang Sunwoo

    2010-10-01

    Full Text Available Huntington disease is a neurodegenerative disorder distinguished by the triad of dominant inheritance, choreoathetosis and dementia, usually with onset in the fourth and fifth decades. It is caused by an unstable cytosine-adenine-guanine (CAG trinucleotide repeat expansion in the gene IT15 in locus 4p16.3. Juvenile HD that constitutes about 3% to 10% of all patients is clinically different from adult-onset form and characterized by a larger number of CAG repeats typically exceeding 60. We report a case of a 6-year-old boy with myoclonic seizure and 140 CAG repeats confirmed by molecular genetic analysis.

  11. Formação pedagógica de professores de nutrição: uma omissão consentida? Teacher training for nutrition professors: a tacitly accepted omission?

    Directory of Open Access Journals (Sweden)

    Nilce Maria da Silva Campos Costa

    2009-02-01

    Full Text Available Apesar dos novos papéis preconizados pelas Diretrizes Curriculares Nacionais aos profissionais de Nutrição, pouca atenção tem sido dada ao desenvolvimento docente para atuação nos novos cenários. O objetivo deste ensaio é o de discutir um dos desafios à formação do nutricionista, a prática docente e a formação pedagógica do professor da área da saúde, para pensar formas de oportunizar um ensino de melhor qualidade, com base em autores que discutem a docência universitária. Identificam-se como causas da resistência docente às mudanças, a desvalorização das atividades de ensino e a supremacia das atividades de pesquisa nas universidades. O estudo permitiu sugerir a necessidade de reflexão por parte dos professores de Nutrição sobre as questões da docência universitária e sobre o desenvolvimento docente em uma perspectiva crítica e reflexiva, que possa ancorar mudanças pedagógicas necessárias à formação de nutricionistas.Despite the new roles called in for the National Curricular Guidelines for teachers in nutrition courses, little attention has been paid to the professional development of the nutrition professional acting as a teacher. Based on the work of authors who discuss university teaching, this essay discusses some of the challenges involved in training nutritionists, such as teaching practice and teacher training for the professor in the health field, with the goal of providing higher-quality teaching. The devaluation of teaching and the supremacy of research at universities have been identified as the causes of teachers' resistance to change. This study reveals the need for professors of nutrition to reflect on the questions of university teaching and teacher development from a critical and reflective perspective which can anchor the pedagogical changes needed to train the nutritionist.

  12. The I Professor Formation in the Wallonian approach.

    Science.gov (United States)

    Aranha, Ana Lúcia Batista; Mrech, Leny Magalhaes; Zacharias, Adriana Pereira Gonçalves; Figueredo, Luana Prado; Mendonça, Catarina Terumi Abe; Fernandes, Maria de Fátima Prado

    2015-12-01

    Objectives Analyze how teachers perceive the construction of their I Professor from the perspective of Wallon and learn about their everyday experiences in school in the condition of being self and other. Method Qualitative, with 13 participants from the Bachelor of Nursing Program. Data collection was carried out in 2013 using interviews that were subjected to thematic analysis. Results Three categories emerged: Construction of the I Professor; living daily life supported by oneself and the other; and the components for constructing the I Professor, highlighting consciousness and valuing of oneself and the other. Conclusion The teachers traveled a path that allowed them to recognize themselves in different movements of the internalization of the I.

  13. [The essence of Professor Wu Lian-Zhong's acupuncture manipulation].

    Science.gov (United States)

    Liu, Jing; Guo, Yi; Wu, Lian-Zhong

    2014-05-01

    The painless needle insertion technique, summarized by Professor WU Lian-zhong during his decades of acupuncture clinical practice is introduced in this article, which is characterized as soft, flexible, fast, plucking and activating antipathogenic qi. The Sancai (three layers) lifting and thrusting manipulation technique is adopted by Professor WU for getting the qi sensation. And features of 10 kinds of needling sensation such as soreness, numbness, heaviness, distension, pain, cold, hot, radiation, jumping and contracture are summarized. Finger force, amplitude, speed and time length are also taken as the basis of reinforcing and reducing manipulations. Moreover, examples are also given to explain the needling technique on some specific points which further embodies Professor WU's unique experiences and understandings on acupuncture.

  14. ATLANTIC and beyond: an interview with Professor Azfar Zaman.

    Science.gov (United States)

    Zaman, Azfar; Wu, Wing

    2015-01-01

    Professor Azfar Zaman speaks to Wing Wu, Commissioning Editor: Professor Azfar Zaman is a Consultant Interventional Cardiologist at Freeman Hospital and Professor of Cardiology at Newcastle University. Following graduation at Leeds Medical School, he completed postgraduate training in cardiology at regional centres in Leeds, London and Cardiff. Prior to his appointment in Newcastle upon Tyne, he was a Fulbright Scholar and British Heart Foundation International Fellow at Mount Sinai Medical Center, New York, USA. He is the Clinical Lead for Coronary Intervention and Director of the Cardiac Catheter Laboratories. In 2012, he was appointed Specialty Group Lead for Cardiovascular Research and has an interest in clinical research, with a particular interest in atherothrombosis in diabetes and clinical trials.

  15. Gender and teamwork: an analysis of professors' perspectives and practices

    Science.gov (United States)

    Beddoes, Kacey; Panther, Grace

    2018-05-01

    Teamwork is increasingly seen as an important component of engineering education programmes. Yet, prior research has shown that there are numerous ways in which teamwork is gendered, and can lead to negative experiences for women students. This article presents the first interview findings on professors' perspectives on gender and teamwork. Semi-structured interviews were conducted with 39 engineering professors to determine what and how they thought about gender in engineering and engineering education. For this article, the parts of the interviews about teamwork are analysed. We conclude that professors need tools to help them facilitate gender-inclusive teamwork, and those tools must address the beliefs that they already hold about teamwork. The findings raise questions about the adoption of evidence-based instructional practices and suggest current teamwork practices may exacerbate gender inequalities in engineering.

  16. [Professor Kazimierz Jaegermann--forensic pathologist--scientist--thinker].

    Science.gov (United States)

    Nasiłowski, Władysław

    2009-01-01

    Professor Kazimierz Jaegermann, a founder of the theory of medico-legal opinionating, passed away 20 years ago. Numerous specialists in forensic medicine and an ever increasing number of lawyers substantiate the importance and value of the creative thought and the entire research work of Professor Jaegermann that have been an inspiration of progress in forensic medicine and in the science of applied law. His unique ability to perform a scientific synthesis leading to recognizing forensic medicine as an applied bridging knowledge points to the eminently creative role played by Professor Jaegermann in development of forensic medicine. There is an urgent need to recall his research activities and to publish a complete collection of his articles and publications. With this idea in mind, I present below an article based on the text published in No. 1 of the Zeszyty Naukowe Katedry Medycyny Sadowej Slaskiej Akademii Medycznej in 1995.

  17. Faculty Agency in Applying for Promotion to Professor

    Directory of Open Access Journals (Sweden)

    Susan K. Gardner

    2017-02-01

    Full Text Available Aim/Purpose: In the United States, faculty who wish to pursue promotion to the rank of professor do so without clear guidance or structure. Even the timing of such a process is nebulous. As such, an individual engages in agentic action to pursue the rank. Background: This study examined the experiences of faculty members who chose to pursue the application process to be promoted to professor but were rejected or dissuaded. Methodology: Utilizing a case study of one institutional setting, we conducted 10 in-depth qualitative interviews. Contribution: Very little is known about the process of promotion to full professor in the U.S. and even less empirical research exists. This study advances knowledge of the process and the experiences of those undertaking it. Findings: We learned that cues from the social context greatly influenced these faculty members’ sense of agency.

  18. [Professor Frantisek Por MD and Professor Robert Klopstock MD, students at Budapest and Prague Faculties of Medicine].

    Science.gov (United States)

    Mydlík, M; Derzsiová, K

    2010-11-01

    Professor Frantisek Por MD and Professor Robert Klopstock MD were contemporaries, both born in 1899, one in Zvolen, the other in Dombovar, at the time of Austro-Hungarian Monarchy. Prof. Por attended the Faculty of Medicine in Budapest from 1918 to 1920, and Prof. Klopstock studied at the same place between 1917 and 1919. From 1920 until graduation on 6th February 1926, Prof. Por continued his studies at the German Faculty of Medicine, Charles University in Prague. Prof. Klopstock had to interrupt his studies in Budapest due to pulmonary tuberculosis; he received treatment at Tatranske Matliare where he befriended Franz Kafka. Later, upon Kafka's encouragement, he changed institutions and continued his studies at the German Faculty of Medicine, Charles University in Prague, where he graduated the first great go. It is very likely that, during their studies in Budapest and Prague, both professors met repeatedly, even though their life paths later separated. Following his graduation, Prof. Por practiced as an internist in Prague, later in Slovakia, and from 1945 in Kosice. In 1961, he was awarded the title of university professor of internal medicine at the Faculty of Medicine, Pavol Jozef Safarik University in Kosice, where he practiced until his death in 1980. Prof. Klopstock continued his studies in Kiel and Berlin. After his graduation in 1933, he practiced in Berlin as a surgeon and in 1938 left for USA. In 1962, he was awarded the title of university professor of pulmonary surgery in NewYork, where he died in 1972.

  19. O DUALISMO DO SER ÓRFICO NA EPÍSTOLA DE PAULO AOS ROMANOS

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    Roger Ribeiro da Silva

    2010-01-01

    Full Text Available Este trabalho consiste na comparação de fragmentos de textos encontrados na obra de Platão e na Epístola aos Romanos atribuída à Paulo. Retirados de inúmeros textos atribuídos a Platão, estes fragmentos tiveram confirmados indícios da teologia órfica pelo professor Alberto Bernabé Pajares. E ao aplicar a Metodologia de Analise do Discurso Teológico, desenvolvido especificamente para este trabalho, e comparado os resultados individuais, encontramos pontos de encontro entre as duas teologias, a Órfica e a Paulina, acentuando o que tange a crença no Dualismo do Ser. A problemática levantada neste trabalho se refere a como a representação1 da alma unida ao corpo, encontrada em escritos paulinistas, apresenta indícios de contatos com fundamentos órficos no berço do cristianismo.

  20. O ESTÁGIO SUPERVISIONADO NA FORMAÇÃO DO PROFESSOR DE FILOSOFIA

    Directory of Open Access Journals (Sweden)

    Regiane Rodrigues Araújo

    2013-06-01

    Full Text Available Os estudos sobre a formação docente nos cursos de licenciatura tem sido objeto de estudo no campo da educação. A defesa do professor intelectual, crítico e reflexivo nem sempre tem considerado a contribuição da Filosofia na elaboração dos seus princípios. O objetivo desta pesquisa é analisar a compreensão dos alunos acerca do Estágio no decorrer do curso de licenciatura.Optou-se, metodologicamente, pela abordagem qualitativa, a revisão bibliográfica, a pesquisa de campo e a análise de conteúdo. A pesquisa de campo consultou dez estudantes de Licenciatura em Filosofia da turma de Prática de Ensino da Universidade Estadual do Ceará.O embasamento teórico para as análises dos dados ancorou-se nos estudos de Gallo (2008, Ghedin (2009, Severino (1994, Lima (2012, Pimenta e Lima (2004, dentre outros. Os resultados da pesquisa revelaram que o Estágio é um dos momentos mais significativos do curso universitário, pois possibilita ao aluno a vivência, na prática,dos ensinamentos teóricos e o contato com a realidade da profissão docente. Cada graduando tem um conceito e um significado para tal vivência, que influenciará, como passo inicial no exercício do magistério e na construção de sua identidade professoral.

  1. [Effective acupoints for bulbar paralysis by professor GAO Weibin].

    Science.gov (United States)

    Kang, Lianru; Zheng, Shuang

    2016-04-01

    Professor GAO Weibin academically advocates, based on basic theory of TCM and theories of different schools, modern science technology should be used for the methods and principles of acupuncture and Chinese medicine for neuropathy, so as to explore and summarize the rules, characteristics and advantages of TCM for nervous system disease, especially bulbar paralysis. During the treatment of bulbar paralysis, professor GAO creatively proposes the effective acupuncture points such as Gongxue, Tunyan-1, Tunyan-2, Fayin, Tiyan and Zhifanliu from the aspects of neuroanatomy, and analyzes their anatomical structure and action mechanism.

  2. A formação do professor de biologia

    OpenAIRE

    Schlichting, Maria Cristina Rodrigues Maranhão

    1997-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias da Educação O estudo evidencia o tratamento dicotômico mantido na estrutura curricular dos cursos de formação do professor de biologia considerando ser essa prática responsável pelos preconceitos que levam à desvalorização da prática pedagógica. O estudo parte da análise da estrutura curricular e aprofunda-se com entrevistas que buscam levantar o posicionamento dos professores dos cursos de Ciências Biológi...

  3. Forecasting the student–professor matches that result in unusually effective teaching

    Science.gov (United States)

    Gross, Jennifer; Lakey, Brian; Lucas, Jessica L; LaCross, Ryan; R Plotkowski, Andrea; Winegard, Bo

    2015-01-01

    Background Two important influences on students' evaluations of teaching are relationship and professor effects. Relationship effects reflect unique matches between students and professors such that some professors are unusually effective for some students, but not for others. Professor effects reflect inter-rater agreement that some professors are more effective than others, on average across students. Aims We attempted to forecast students' evaluations of live lectures from brief, video-recorded teaching trailers. Sample Participants were 145 college students (74% female) enrolled in introductory psychology courses at a public university in the Great Lakes region of the United States. Methods Students viewed trailers early in the semester and attended live lectures months later. Because subgroups of students viewed the same professors, statistical analyses could isolate professor and relationship effects. Results Evaluations were influenced strongly by relationship and professor effects, and students' evaluations of live lectures could be forecasted from students' evaluations of teaching trailers. That is, we could forecast the individual students who would respond unusually well to a specific professor (relationship effects). We could also forecast which professors elicited better evaluations in live lectures, on average across students (professor effects). Professors who elicited unusually good evaluations in some students also elicited better memory for lectures in those students. Conclusions It appears possible to forecast relationship and professor effects on teaching evaluations by presenting brief teaching trailers to students. Thus, it might be possible to develop online recommender systems to help match students and professors so that unusually effective teaching emerges. PMID:24953773

  4. Interações entre o aluno com surdez, o professor e o intérprete em aulas de física: uma perspectiva Vygotskiana

    Directory of Open Access Journals (Sweden)

    Jaqueline Santos Vargas

    2014-09-01

    Full Text Available O estudo apresenta uma análise das interações entre o aluno com surdez, o professor e o intérprete em sala de aula, além do papel desses sujeitos no processo de inclusão do aluno surdo. Trata-se de uma pesquisa qualitativa realizada em 10 escolas públicas de Ensino Médio de Campo Grande-MS que receberam 24 alunos com surdez. Nessa análise utilizamos a abordagem histórico cultural de Vygotsky. Os resultados evidenciaram que apenas o intérprete interage efetivamente com esses alunos e pouco colabora para que eles interajam com pessoas que não dominam a Língua Brasileira de Sinais. Em sala de aula, o professor transfere ao intérprete a responsabilidade pelo ensino e a aprendizagem desses alunos.

  5. Émile-G. Léonard e sua contribuição aos estudos do protestantismo brasileiro

    OpenAIRE

    Carvalho, Marcone Bezerra

    2013-01-01

    Durante o período em que esteve no Brasil (1948-1950) como professor da Universidade de São Paulo (USP), o historiador francês Émile-G. Léonard analisou a presença protestante no país e escreveu uma obra que, passadas seis décadas, ainda se constitui na principal interpretação do movimento evangélico brasileiro. Influenciado pela Escola dos Annales - particularmente por Lucien Fevbre -, o catedrático da Sorbonne foi o primeiro historiador ligado ao movimento a tomar o Brasil como objeto de es...

  6. Educação, trabalho e proletarização: o professor enquanto trabalhador docente

    Directory of Open Access Journals (Sweden)

    Cássio Diniz Hiro

    2013-05-01

    Full Text Available Este presente artigo tem como objetivo oferecer uma pequena contribuição ao debate acerca do processo de proletarização do docente na educação brasileira. Tornou-se comum em parte dos debatedores assinalarem que o professor não pode se caracterizar enquanto um trabalhador em educação, ou seja, como parte integrante da classe social dos trabalhadores, classificando-os enquanto membros de uma dita “classe média”. Neste artigo procuramos apontar que as transformações sócio-econômicas e o desenvolvimento do modo de produção capitalista no Brasil provocaram uma profunda metamorfose no âmbito do papel social do decente brasileiro. Para isso, apresentamos algumas análises baseadas no referencial teórico marxista, fruto das contribuições ao materialismo histórico-dialético ao legado de Marx e Engels.

  7. A internet na escola fundamental: sondagem de modos de uso por professores

    Directory of Open Access Journals (Sweden)

    Santos Gilberto Lacerda

    2003-01-01

    Full Text Available Esta investigação objetiva o esclarecimento de modalidades de uso da internet em situações de ensino fundamental, em escolas das redes pública e particular do Distrito Federal. Trata-se de uma pesquisa que empregou leitura qualitativa de dados quantitativos em que, por meio de questionários, entrevistas e observações diretas, abordamos a atuação de vinte professores para explicitar de que forma os conteúdos disponibilizados por meio da internet estão sendo apreendidos e trabalhados em sala de aula, o tipo de navegação nos hipertextos eletrônicos que tem sido proposto aos alunos e uma tipologia de modalidades de uso da internet na educação. Os dados indicam que há quatro modalidades de navegação (aleatória e linear; orientada e problematizada; por meio de pedagogia de projetos e por meio de abordagens de construção de hipertextos. Indicam também que os professores são capazes de avançar em uma utilização mais interessante da internet como meio de ensino e de aprendizagem e que a escola, com seu ritmo e ritos, constitui uma amarra importante. Sem dúvida, há um clamor geral pela mudança. Se os alunos sentem-se pouco à vontade com a forma e o hermetismo com que as relações educativas vêm sendo conduzidas, o que é traduzido na prática por um desinteresse sistemático pela escola, o mesmo parece acontecer com os professores, sobretudo quando eles são cobrados por gestores, pais, alunos e teóricos da educação para assumirem posturas docentes para as quais eles não foram preparados.

  8. Continuous deep sedation, physician-assisted suicide, and euthanasia in Huntington's disorder.

    Science.gov (United States)

    Lindblad, Anna; Juth, Niklas; Fürst, Carl Johan; Lynöe, Niels

    2010-11-01

    To investigate the attitudes among Swedish physicians and the general public towards continuous deep sedation (CDS) as an alternative treatment for a competent, not imminently dying patient with Huntington's disorder requesting physician-assisted suicide (PAS) and euthanasia. A questionnaire was distributed to 1200 physicians in Sweden and 1201 individuals in Stockholm. It consisted of three parts: 1) A vignette about a competent patient with Huntington's disease requesting PAS. When no longer competent, relatives request euthanasia on behalf of the patient. Responders were asked about their attitudes towards these requests and whether CDS would be an acceptable alternative. 2) General questions about PAS and euthanasia. 3) Background variables. The response rate was 56% (physicians) and 52% (general public). The majority of the general public and a fairly large proportion of physicians reported more liberal views on CDS than are expressed in current Swedish and international recommendations. In light of the results, we suggest that there is a need for a broader discussion about the recommendations for CDS, with a special focus on the needs of patients with progressive neurodegenerative disorders.

  9. Insights into gait disorders: walking variability using phase plot analysis, Huntington's disease.

    Science.gov (United States)

    Collett, Johnny; Esser, Patrick; Khalil, Hanan; Busse, Monica; Quinn, Lori; DeBono, Katy; Rosser, Anne; Nemeth, Andrea H; Dawes, Helen

    2014-09-01

    Huntington's disease (HD) is a progressive inherited neurodegenerative disorder. Identifying sensitive methodologies to quantitatively measure early motor changes have been difficult to develop. This exploratory observational study investigated gait variability and symmetry in HD using phase plot analysis. We measured the walking of 22 controls and 35 HD gene carriers (7 premanifest (PreHD)), 16 early/mid (HD1) and 12 late stage (HD2) in Oxford and Cardiff, UK. The unified Huntington's disease rating scale-total motor scores (UHDRS-TMS) and disease burden scores (DBS) were used to quantify disease severity. Data was collected during a clinical walk test (8.8 or 10 m) using an inertial measurement unit attached to the trunk. The 6 middle strides were used to calculate gait variability determined by spatiotemporal parameters (co-efficient of variation (CoV)) and phase plot analysis. Phase plots considered the variability in consecutive wave forms from vertical movement and were quantified by SDA (spatiotemporal variability), SDB (temporal variability), ratio ∀ (ratio SDA:SDB) and Δangleβ (symmetry). Step time CoV was greater in manifest HD (p0.05). Phase plot analysis identified differences between manifest HD and controls for SDB, Ratio ∀ and Δangle (all pplot analysis may be a sensitive method of detecting gait changes in HD and can be performed quickly during clinical walking tests. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. Electronic Transport in Single-Stranded DNA Molecule Related to Huntington's Disease

    Science.gov (United States)

    Sarmento, R. G.; Silva, R. N. O.; Madeira, M. P.; Frazão, N. F.; Sousa, J. O.; Macedo-Filho, A.

    2018-04-01

    We report a numerical analysis of the electronic transport in single chain DNA molecule consisting of 182 nucleotides. The DNA chains studied were extracted from a segment of the human chromosome 4p16.3, which were modified by expansion of CAG (cytosine-adenine-guanine) triplet repeats to mimics Huntington's disease. The mutated DNA chains were connected between two platinum electrodes to analyze the relationship between charge propagation in the molecule and Huntington's disease. The computations were performed within a tight-binding model, together with a transfer matrix technique, to investigate the current-voltage (I-V) of 23 types of DNA sequence and compare them with the distributions of the related CAG repeat numbers with the disease. All DNA sequences studied have a characteristic behavior of a semiconductor. In addition, the results showed a direct correlation between the current-voltage curves and the distributions of the CAG repeat numbers, suggesting possible applications in the development of DNA-based biosensors for molecular diagnostics.

  11. Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders

    Directory of Open Access Journals (Sweden)

    Sidharth Mehan

    2017-01-01

    Full Text Available Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic acid has been used in rodents to model Huntington's disease where mitochondrial dysfunction and oxidative damages are primary pathological hallmarks for neuronal damage. Improvements in learning and memory abilities, recovery of energy levels, and reduction of excitotoxicity damage can be achieved through activation of Adenyl cyclase enzyme by a specific phytochemical forskolin. In this study, intraperitoneal administration of 10 mg/kg 3-nitropropionic acid for 15 days in rats notably reduced body weight, worsened motor cocordination (grip strength, beam crossing task, locomotor activity, resulted in learning and memory deficits, greatly increased acetylcholinesterase, lactate dehydrogenase, nitrite, and malondialdehyde levels, obviously decreased adenosine triphosphate, succinate dehydrogenase, superoxide dismutase, catalase, and reduced glutathione levels in the striatum, cortex and hippocampus. Intragastric administration of forskolin at 10, 20, 30 mg/kg dose-dependently reversed these behavioral, biochemical and pathological changes caused by 3-nitropropionic acid. These results suggest that forskolin exhibits neuroprotective effects on 3-nitropropionic acid-induced Huntington's disease-like neurodegeneration.

  12. Nonparametric modeling and analysis of association between Huntington's disease onset and CAG repeats.

    Science.gov (United States)

    Ma, Yanyuan; Wang, Yuanjia

    2014-04-15

    Huntington's disease (HD) is a neurodegenerative disorder with a dominant genetic mode of inheritance caused by an expansion of CAG repeats on chromosome 4. Typically, a longer sequence of CAG repeat length is associated with increased risk of experiencing earlier onset of HD. Previous studies of the association between HD onset age and CAG length have favored a logistic model, where the CAG repeat length enters the mean and variance components of the logistic model in a complex exponential-linear form. To relax the parametric assumption of the exponential-linear association to the true HD onset distribution, we propose to leave both mean and variance functions of the CAG repeat length unspecified and perform semiparametric estimation in this context through a local kernel and backfitting procedure. Motivated by including family history of HD information available in the family members of participants in the Cooperative Huntington's Observational Research Trial (COHORT), we develop the methodology in the context of mixture data, where some subjects have a positive probability of being risk free. We also allow censoring on the age at onset of disease and accommodate covariates other than the CAG length. We study the theoretical properties of the proposed estimator and derive its asymptotic distribution. Finally, we apply the proposed methods to the COHORT data to estimate the HD onset distribution using a group of study participants and the disease family history information available on their family members. Copyright © 2013 John Wiley & Sons, Ltd.

  13. [Predictors of mental and physical quality of life in Huntington's disease].

    Science.gov (United States)

    Brugger, F; Hepperger, C; Hametner, E-M; Holl, A K; Painold, A; Schusterschitz, C; Bonelli, R; Holas, C; Wenning, G K; Poewe, W; Seppi, K

    2015-02-01

    The assessment of health-related quality of life (hrQoL) is an important tool in therapy studies and in the treatment of patients with Huntington's disease (HD). In the absence of causal interventions, HD therapy targets the alleviation of symptoms aiming to improve impaired hrQoL. The aim of this study was to determine the impact of disease characteristics on hrQoL in HD. A total of 80 genetically confirmed HD patients underwent an assessment using the Unified Huntington's Disease Rating Scale, the Beck Depression Inventory, the Hamilton Rating Scale and the SF-36, a scale for the assessment of physical and mental QoL. Multiple regression analysis revealed that health-related physical and mental QoL was considerably influenced by the functional capacity. The mental QoL also correlated with the degree of depressive symptoms, age and the number of CAG repeats. However, there was no statistical relation between QoL and motor and cognitive abilities. This study underlines the relationship between function capacity and depressive symptoms with mental and physical QoL. This is the first time that hrQoL has been investigated in a German speaking cohort. The results are in accordance with previous studies of hrQoL in HD.

  14. Neurotensin receptor binding levels in basal ganglia are not altered in Huntington's chorea or schizophrenia

    International Nuclear Information System (INIS)

    Palacios, J.M.; Chinaglia, G.; Rigo, M.; Ulrich, J.; Probst, A.

    1991-01-01

    Autoradiographic techniques were used to examine the distribution and levels of neurotensin receptor binding sites in the basal ganglia and related regions of the human brain. Monoiodo ( 125 I-Tyr3)neurotensin was used as a ligand. High amounts of neurotensin receptor binding sites were found in the substantia nigra pars compacta. Lower but significant quantities of neurotensin receptor binding sites characterized the caudate, putamen, and nucleus accumbens, while very low quantities were seen in both medial and lateral segments of the globus pallidus. In Huntington's chorea, the levels of neurotensin receptor binding sites were found to be comparable to those of control cases. Only slight but not statistically significant decreases in amounts of receptor binding sites were detected in the dorsal part of the head and in the body of caudate nucleus. No alterations in the levels of neurotensin receptor binding sites were observed in the substantia nigra pars compacta and reticulata. These results suggest that a large proportion of neurotensin receptor binding sites in the basal ganglia are located on intrinsic neurons and on extrinsic afferent fibers that do not degenerate in Huntington's disease

  15. Representações ideológicas no Twitter sobre a profissão-perigo professor: uma análise sob a perspectiva da ACD.

    Directory of Open Access Journals (Sweden)

    Silvia Adelia Henrique Guimarães

    2011-07-01

    Full Text Available Objetivamos, neste trabalho, analisar alguns discursos sobre o professor no Twitter, perguntando, especificamente, como esta profissão é representada pelo prisma das situações práticas não idealizadas. A partir de uma notícia difundida na mídia sobre a agressão a uma professora em Porto Alegre, selecionamos noventa e um tweets para a investigação, buscando apoio teórico na Análise Crítica do Discurso (FAIRCLOUGH, 2003. Nesta microanálise, concentramo-nos no significado representacional, que corresponde aos modos de interação entre discurso e prática social (VAN LEEUWEN, 1997; THOMPSON, 2009. Os resultados gerais sugerem a uma naturalização e reprodução do discurso do professor como refém dos valores ideológicos que circulam na sociedade; b a ênfase dada ao aluno-agressor, que apesar de bastante criticado, parece receber autorização para suas ações. Desvelam uma cristalização da violência contra o professor, visto que a indignação implicada nos comentários não se seguiu de sugestões para mudanças, nem práticas, nem discursivas, contra este tipo de violência. Por fomentar reflexões sobre as representações ideológicas socialmente difundidas sobre a profissão professor, esta pesquisa pode revelar-se um apoio significativo para pesquisas em Linguística Aplicada, e também para outras áreas das Ciências Sociais, gerando avanço e sistematização dos achados.

  16. Inclusão de alunos com deficiência na aula de educação física: identificando dificuldades, ações e conteúdos para prover a formação do professor

    Directory of Open Access Journals (Sweden)

    Maria Luiza Salzani Fiorini

    2014-09-01

    Full Text Available O transcorrer habitual das aulas de Educação Física não parece tranquilo quando o professor defronta-se com alunos com deficiência, principalmente no ensino regular. Nesse sentido, objetivou-se identificar as dificuldades encontradas por professores de Educação Física para incluir alunos com deficiência e sugerir ações e conteúdos a partir dessas dificuldades com a intenção de promover a formação dos professores. Participaram da pesquisa 17 professores de Educação Física que atuavam em escolas, do 1° ao 5° ano, divididos em dois grupos: manhã e tarde. Três encontros para cada grupo de professores foram realizados. Em dois encontros foram coletadas informações por meio de Grupo Focal e, no outro encontro, as informações foram apresentadas aos participantes. Realizou-se uma análise de conteúdo do tipo categorial. Dessa análise emergiram oito categorias de dificuldades atribuídas: 1 à Formação; 2 à questão Administrativo-escolar; 3 ao Aluno; 4 ao Diagnóstico; 5 à Família; 6 ao Recurso Pedagógico; 7 à Estratégia de ensino; 8 à Educação Física. Diante dos resultados foram sugeridas ações e conteúdos para promover a formação dos professores. Conclui-se que, ao propor uma formação para professores de Educação Física, com foco na inclusão educacional, é preciso identificar e assumir as dificuldades encontradas, uma vez que os professores relataram que a dificuldade não era, somente, saber o que fazer para incluir, ou qual recurso selecionar, mas que havia outras questões, como, as administrativas, as familiares e as decorrentes da estrutura escolar.

  17. Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model

    DEFF Research Database (Denmark)

    Aidt, Frederik Heurlin; Nielsen, Signe Marie Borch; Kanters, Jørgen

    2013-01-01

    Metabolic dysfunction and mitochondrial involvement are recognised as part of the pathology in Huntington's Disease (HD). Post-mortem examinations of the striatum from end-stage HD patients have shown a decrease in the in vitro activity of complexes II, III and IV of the electron transport system...

  18. Transgenic Rat Model of Huntington's Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients.

    Czech Academy of Sciences Publication Activity Database

    Mazurová, Y.; Anděrová, Miroslava; Němečková, I.; Bezrouk, A.

    2014-01-01

    Roč. 2014, Aug 03 (2014), s. 291531 ISSN 2314-6133 R&D Projects: GA ČR(CZ) GBP304/12/G069 Grant - others:GA MŠk(CZ) Prvouk P37 Institutional support: RVO:68378041 Keywords : Huntington's Disease * neurodegenerative process in the brain Subject RIV: FH - Neurology Impact factor: 1.579, year: 2014

  19. Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for Huntington disease

    NARCIS (Netherlands)

    Abada, Yah-se K.; Nguyen, Huu Phuc; Schreiber, Rudy; Ellenbroek, Bart

    2013-01-01

    Rationale: Huntington disease (HD) is frequently first diagnosed by the appearance of motor symptoms; the diagnosis is subsequently confirmed by the presence of expanded CAG repeats (> 35) in the HUNTINGTIN (HTT) gene. A BACHD rat model for HD carrying the human full length mutated HTT with 97

  20. Assessing Impairment of Executive Function and Psychomotor Speed in Premanifest and Manifest Huntington's Disease Gene-expansion Carriers

    DEFF Research Database (Denmark)

    Unmack Larsen, Ida; Vinther-Jensen, Tua; Gade, Anders

    2015-01-01

    Executive functions (EF) and psychomotor speed (PMS) has been widely studied in Huntington's disease (HD). Most studies have focused on finding markers of disease progression by comparing group means at different disease stages. Our aim was to investigate performances on nine measures of EF and PMS...

  1. A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.

    Directory of Open Access Journals (Sweden)

    John P Miller

    Full Text Available A genome-scale RNAi screen was performed in a mammalian cell-based assay to identify modifiers of mutant huntingtin toxicity. Ontology analysis of suppressor data identified processes previously implicated in Huntington's disease, including proteolysis, glutamate excitotoxicity, and mitochondrial dysfunction. In addition to established mechanisms, the screen identified multiple components of the RRAS signaling pathway as loss-of-function suppressors of mutant huntingtin toxicity in human and mouse cell models. Loss-of-function in orthologous RRAS pathway members also suppressed motor dysfunction in a Drosophila model of Huntington's disease. Abnormal activation of RRAS and a down-stream effector, RAF1, was observed in cellular models and a mouse model of Huntington's disease. We also observe co-localization of RRAS and mutant huntingtin in cells and in mouse striatum, suggesting that activation of R-Ras may occur through protein interaction. These data indicate that mutant huntingtin exerts a pathogenic effect on this pathway that can be corrected at multiple intervention points including RRAS, FNTA/B, PIN1, and PLK1. Consistent with these results, chemical inhibition of farnesyltransferase can also suppress mutant huntingtin toxicity. These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease.

  2. First molecular modeling report on novel arylpyrimidine kynurenine monooxygenase inhibitors through multi-QSAR analysis against Huntington's disease: A proposal to chemists!

    Science.gov (United States)

    Amin, Sk Abdul; Adhikari, Nilanjan; Jha, Tarun; Gayen, Shovanlal

    2016-12-01

    Huntington's disease (HD) is caused by mutation of huntingtin protein (mHtt) leading to neuronal cell death. The mHtt induced toxicity can be rescued by inhibiting the kynurenine monooxygenase (KMO) enzyme. Therefore, KMO is a promising drug target to address the neurodegenerative disorders such as Huntington's diseases. Fiftysix arylpyrimidine KMO inhibitors are structurally explored through regression and classification based multi-QSAR modeling, pharmacophore mapping and molecular docking approaches. Moreover, ten new compounds are proposed and validated through the modeling that may be effective in accelerating Huntington's disease drug discovery efforts. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Quando o garrancho é disgrafia: a atuação do professor diante dessa dificuldade de aprendizagem

    Directory of Open Access Journals (Sweden)

    Felipe Costa Negrão

    2014-07-01

    Full Text Available Atualmente, estamos vivendo em dias, onde os conceitos são mais importantes que as atitudes, ou o bem estar de nossos educandos. A sede por números positivos nas avaliações do MEC, por muitas vezes impossibilitam que o desenvolvimento de nossos alunos seja equilibrado. O professor é o profissional que está em contato diário com estes sujeitos aprendentes, logo é ele que observará as dificuldades apresentadas pelos mesmos. Perdurou-se por tempos, o rótulo de que os alunos que apresentavam alguma dificuldade de aprendizagem eram desprovidos de inteligência, sendo classificados até como “burros”, entretanto, atualmente podemos ver que este campo da educação, tem ganhado uma atenção especial. O presente artigo tem como propósito apresentar algumas considerações acerca da atuação do professor diante a disgrafia, tendo como objetivo geral compreender como o educador deve posicionar-se ao encontrar em sala de aula um aluno com sinais de disgrafia, objetivando a melhora da aprendizagem deste educando. A metodologia utilizada na pesquisa é de caráter bibliográfico, onde recorremos a autores como Topczewski (2011, Almeida (2010, Fonseca (1995, Vallet (1977, entre outros. Elucidamos a importância da formação continuada, visto que as dificuldades de aprendizagem não são estudadas na graduação, e os educadores precisam estar preparados para lidarem com alunos que possuam disgrafia em sala de aula, na tentativa de evitar rótulos enganosos e desempenhos insatisfatórios. Enfim, compreendemos que a função do professor diante da disgrafia é ser um facilitador e um motivador, e também deve mostrar a este educando as suas habilidades e competências. Espera-se, então que o professor desperte-se, e promova mudanças em sua sala de aula, visando alcançar estes alunos que convivem com esta limitação em seu dia-a-dia. Em conformidade com o que foi apresentado nesta pesquisa, o aluno com disgrafia apresenta suas

  4. Life Stories of Mathematics Teacher Histórias de Vida de Professores de Matemática

    Directory of Open Access Journals (Sweden)

    Emerson Rolkouski

    2008-10-01

    Full Text Available The objective of this work is to understand how a Mathematics teacher becomes the teacher of Mathematics that he is. In other words, to understand how the individual becomes, through his life, his relationship with other individuals, this teacher of Mathematics, with these ideas, practices, and resistances. Four Mathematics teachers, with different degree levels, were interviewed according to the methodological parameters of the Oral History. Their testimonies allowed the composition of a scenary wich made it possible to extend the comprehension concerning becoming “the” Mathematics teacher. Their life stories were read with differentiated lenses. Under a sociological focus, based on Norbert Elias and Pierre Bourdieu’s works, under the perspective of psychology, based on Jerome Bruner’s works and finally a last reading denominated scientific-literary, in which the testimony is read through the analogy of literary texts. These readings presented, considerations were made on their possibilities and impossibilities facing the understanding of “how a teacher of Mathematics becomes ‘the’ teacher of Mathematics that he is”. Key Words: Mathematic Education. Oral History. Teachers Formation.O objetivo deste trabalho é compreender como um professor de Matemática torna-se o professor de Matemática que é. Ou seja, compreender como o indivíduo vai se tornando, ao longo de sua vida, de sua relação com outros indivíduos, este professor de Matemática: com estas idéias, práticas, resistências. Quatro professores de Matemática, com diferentes níveis de titulação, foram entrevistados segundo os parâmetros metodológicos da História Oral. Seus depoimentos permitiram a composição de um cenário que possibilitou ampliar as compreensões acerca do tornar-se “o” professor de Matemática. As histórias de vida dos depoentes foram lidas com lentes diferenciadas: sob um enfoque sociológico, fundamentado nos trabalhos de Norbert

  5. Formação reflexiva: representações dos professores acerca do uso de portfólio reflexivo na formação de médicos e enfermeiros

    Directory of Open Access Journals (Sweden)

    Roseli Ferreira da Silva

    Full Text Available Esta investigação discute a utilização de Portfólio Reflexivo (PR na formação de profissionais de Saúde na Unidade de Prática Profissional, da Faculdade de Medicina de Marília, São Paulo, Brasil. O objetivo foi analisar as percepções dos professores quanto ao uso do PR nos cursos de Enfermagem e de Medicina. A abordagem qualitativa foi a opção metodológica, tendo a coleta de dados sido feita mediante entrevista individual com os professores. A análise dos dados foi realizada por meio da técnica de análise de conteúdo. Esta análise permitiu elaborar uma síntese de considerações sobre a utilização do portfólio enquanto estratégia para formação profissional. O PR, na perspectiva dos professores entrevistados, possibilitou a estimulação da capacidade reflexiva dos estudantes e um acompanhamento contínuo dos processos relativos ao seu desenvolvimento pessoal e profissional. Foi considerado como uma estratégia inovadora e, também, muito trabalhosa, requerendo tempo e dedicação dos professores para implementá-lo.

  6. Conteúdos linguísticos como subsídio à formação de professores alfabetizadores - a experiência do Brasil e de Portugal

    Directory of Open Access Journals (Sweden)

    Dalva Maria Alves Godoy

    Full Text Available Resumo: Objetiva identificar em dois programas de formação de professores alfabetizadores - no Brasil, Pacto Nacional pela Alfabetização na Idade Certa (Pnaic e, em Portugal, Programa Nacional do Ensino do Português (Pnep - os conteúdos linguísticos relacionados ao ensino da leitura que fundamentaram a atualização dos professores com vistas a compreender como as descobertas científicas penetram o campo pedagógico. Por meio de análise documental, são apresentadas, de forma resumida, a estrutura e a organização dos dois programas e os respectivos conteúdos de formação. Há muita similaridade entre os dois programas com relação à organização e às estratégias metodológicas e há diferenças importantes quanto à atualidade dos conteúdos oferecidos aos professores alfabetizadores, assim como o tempo de formação aplicado a este conteúdo. A formação linguística do professor é essencial para desenvolver competência para o ensino da língua e, por conseguinte, melhorar as habilidades de ler e escrever dos alunos do ensino fundamental.

  7. A Group Interview about Publishing with Professor Jack Zipes

    Directory of Open Access Journals (Sweden)

    Emma Louise Parfitt

    2016-10-01

    Full Text Available The conversation piece is the product of a group interview with Professor Jack Zipes and provides useful insights about publishing for early career researchers across disciplines. Based on his wider experiences as academic and writer, Professor Zipes answered questions from PhD researchers about: writing books, monographs and edited collections; turning a PhD thesis into a monograph; choosing and approaching publishers; and the advantages of editing books and translations. It presents some general advice for writing and publishing aimed at postgraduate students. Professor Zipes is an Emeritus Professor at the University of Minnesota Twin Cities, United States, a world expert on fairy tales and storytelling highlighting the social and historical dimensions of them. Zipes has forty years of experience publishing academic and mass-market books, editing anthologies, and translating work from French, German and Italian. His best known books are Breaking the Magic Spell (1979, Fairy Tales and the Art of Subversion (1983, The Irresistible Fairy Tale: The Cultural and Social History of a Genre (2012, and The Original Folk and Fairy Tales of the Brothers Grimm (2014.

  8. "Dear Professor: This Is What I Want You to Know."

    Science.gov (United States)

    Workman, Brooke

    1986-01-01

    Describes high school students' letters written to help their teacher interpret youth culture to college professors at an upcoming seminar. Essays reflected four themes: (1) a search for family, (2) identity problems and loneliness, (3) living with rapid change, and (4) fear of failure, especially in college. (2 references) (MLH)

  9. Kant as a Professor: Some Lessons for Today's Intellectuals ...

    African Journals Online (AJOL)

    The thoughts of every great philosopher is measured and represented by the history of his social background. It is indeed, more appropriate particularly in the case of a great philosopher like Immanuel Kant to single out for special recognition the outstanding characteristics of his early life on his career as a professor of ...

  10. The rotor theories by Professor Joukowsky: Vortex theories

    DEFF Research Database (Denmark)

    Okulov, Valery L.; Sørensen, Jens Nørkær; Wood, David H.

    2015-01-01

    This is the second of two articles with the main, and largely self-explanatory, title "Rotor theories by Professor Joukowsky". This article considers rotors with finite number of blades and is subtitled "Vortex theories". The first article with subtitle "Momentum theories", assessed the starring...

  11. The Education of an English Professor: The Biographical Narrative

    Science.gov (United States)

    González Valencia, Heriberto; Enríquez, Jakeline Amparo Villota; Ramos Acosta, Lizeth

    2018-01-01

    This article is the result of a qualitative research following the characteristics of hermeneutical research aims to understand the training process of the English university professor, taking into account factors that affect and surround the social, economic, and cultural environment; in which the experience and the story of life, shape the…

  12. Professor: A motorized field-based phenotyping cart

    Science.gov (United States)

    An easy-to-customize, low-cost, low disturbance, motorized proximal sensing cart for field-based high-throughput phenotyping is described. General dimensions, motor specifications, and a remote operation application are given. The cart, named Professor, supports mounting multiple proximal sensors an...

  13. Professor Age and Gender Affect Student Perceptions and Grades

    Science.gov (United States)

    Joye, Shauna W.; Wilson, Janie H.

    2015-01-01

    Student evaluations provide rich information about teaching performance, but a number of factors beyond teacher effectiveness influence student evaluations. In this study we examined the effects of professor gender and perceived age on ratings of effectiveness and rapport as well as academic performance. We also asked students to rate professor…

  14. Professor Rastislav Dzúrik: the Man and the Scientist.

    Science.gov (United States)

    Derzsiová, Katarina; Mydlík, Miroslav

    2016-02-01

    Rastislav Dzrik, finished his medical study at the Medical School of Comenius University in Bratislava in 1953. After graduation he began to work at the Institute of chemistry and biochemistry of the Medical School and in 1957 he continued working at the IIIrd Internal Clinic of this faculty, which became later the base of "Internal School of Professor T. R. Niederland" with biochemical focusing. In the year 1967 ProfessorDzrik in cooperation with ProfessorJan Brod founded the Nephrological Section of the Slovak Internal Society and then the postgraduate scientific-research activity in nephrology began. The main topics of his scientific activity, in which he received many priority results, were: Isolation and characteristic of inhibitor of glucose utilisation and of inhibitor of renal gluconeogenesis; Effect of "middle molecular substances, especially in the development of renal insufficiency; Isolation and identification of hippurate and pseudouridine. His publishing activity was manifested in more than 500 scientific papers, several monographs and many chapters in various textbooks and manuals of internal medicine and clinical biochemistry, and more than 1,000 citations. The most important success of Professor Dzrik was the textbook "Nephrology which was published in 2004 and he was its main editor. Rastislav Dzriks impact on the field of Nephrology in Slovakia was manifold. It included his complex work of clinical nephrology, his pedagogical activities, and last but not least his excellent organizing abilities.

  15. The Effect of Professor's Attractiveness on Distance Learning Students

    Science.gov (United States)

    Liu, Jeanny; Tomasi, Stella D.

    2015-01-01

    Technology enabled learning is becoming more popular and pervasive in education. While the effectiveness of distance learning versus traditional classroom education is strongly debated, human factors such as students' perception of their professors can influence their desire to learn. This research examines the perceptual effect of attractive…

  16. Professor Oberth and Dr. von Braun at ARS Banquet

    Science.gov (United States)

    1961-01-01

    Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

  17. The benefits of being economics professor A (and not Z)

    NARCIS (Netherlands)

    van Praag, C.M.; van Praag, B.M.S.

    2007-01-01

    Alphabetic name ordering on multi-authored academic papers, which is the convention in the economics discipline and various other disciplines, is to the advantage of people whose last name initials are placed early in the alphabet. As it turns out, Professor A, who has been a first author more often

  18. Professor Lisa Aranson on JA Green (a pioonier artist photographer ...

    African Journals Online (AJOL)

    Jonathan Adagogo Green's photographic and artistic contributions working in his countryside, the Niger Delta of Nigeria is reviewed by Professor Lisa Aranson. Aranson in a public lecture presentation on the stand-point of art history thinks of J.A. Green as having operated in two worlds of which he is said to have initiated in ...

  19. Teaching the College "Nones": Christian Privilege and the Religion Professor

    Science.gov (United States)

    Riswold, Caryn D.

    2015-01-01

    Working with undergraduate students invites teachers into relationship and conversation with young people at a time when they are emerging as adults and forming their identities. Faith is one area of identity formation often attended to by scholars, college professors, and their institutions. But within that, little attention has been paid to…

  20. An Examination of Assistant Professors' Project Management Practices

    Science.gov (United States)

    Alpert, Shannon Atkinson; Hartshorne, Richard

    2013-01-01

    Purpose: The purpose of this research was to identify factors that influence the use of project management in higher education research projects by investigating the project management practices of assistant professors. Design/methodology/approach: Using a grounded theory approach that included in-depth, semi-structured interviews with 22…

  1. Burnout Syndrome and Self-Efficacy Beliefs in Professors

    Science.gov (United States)

    García Padilla, Arlington Antonio; Escorcia Bonivento, Carla Vanessa; Perez Suarez, Blinis Sat

    2017-01-01

    The presence of the Burnout syndrome in professors may be regarded as a deterioration of their mental health with negative impacts on their job performance. It is known that teachers develop different activities in the areas of teaching, outreach and research. This study aims to analyze the relationship between the Burnout syndrome and…

  2. Dilemmas of a Newly Recruited Academic Qualified Professor: A Case

    Science.gov (United States)

    Agrawal, Anand

    2015-01-01

    This case describes the situation of a newly recruited academic professor who volunteered to teach a course on Research Methods to first-term MBA students in a practitioner-oriented case method Business School. Research Methods is a unique course due to its relevance not only in business but also across all graduate programs. Instructional and…

  3. "Women in Science" with Professor Jocelyn Bell Burnell

    Indian Academy of Sciences (India)

    Prof. Dame Jocelyn Bell Burnell is currently a visiting Professor at the. University of Oxford UK and a Fellow of Mansfield College. In a career spanning over four decades, she has made outstanding contributions to Astronomy and the public understanding of Science. As a Ph.D student in Cambridge. University she was ...

  4. Why Don't All Professors Use Computers?

    Science.gov (United States)

    Drew, David Eli

    1989-01-01

    Discusses the adoption of computer technology at universities and examines reasons why some professors don't use computers. Topics discussed include computer applications, including artificial intelligence, social science research, statistical analysis, and cooperative research; appropriateness of the technology for the task; the Computer Aptitude…

  5. The Professor as Intern: Approaches to Teaching Advertising Creativity.

    Science.gov (United States)

    Schamber, Linda

    Drawing upon the experiences of a participant in the Visiting Professor Program sponsored by the Advertising Education Foundation of the American Advertising Federation and the American Academy of Advertising, this paper discusses the advantages such programs can have for both the host company and the participant. The first section of the paper…

  6. Ten Things Every Professor Should Know about Assessment

    Science.gov (United States)

    Wolf, Kenneth; Dunlap, Joanna; Stevens, Ellen

    2012-01-01

    This article describes ten key assessment practices for advancing student learning that all professors should be familiar with and strategically incorporate in their classrooms and programs. Each practice or concept is explained with examples and guidance for putting it into practice. The ten are: learning outcomes, performance assessments,…

  7. Virginia Tech Wildlife Professor Helping To Save Florida Panther

    OpenAIRE

    Davis, Lynn

    2003-01-01

    With few Florida panthers now in existence, Mike Vaughan, Virginia Tech professor of wildlife and sciences in the College of Natural Resources, has been appointed to serve on the Florida Panther Scientific Review Team (SRT). Vaughan and other SRT members have made several trips to Naples, Fla., to interview state and federal biologists directly involved with the recovery of the Florida panther.

  8. How Not to Lose Face on Facebook, for Professors

    Science.gov (United States)

    Young, Jeffrey R.

    2009-01-01

    For years college administrators have warned students to watch their step in online social realms, noting that sharing too much could hurt them later on if future employees saw their drunken party pictures or boorish writings. Now that professors and administrators are catching Facebook fever, they should heed their own advice. The author…

  9. Tribute to the legend Mr. Veterinary Public Health, Professor James ...

    African Journals Online (AJOL)

    The author was also destined during his Sabbatical Leave to have an interactive interview session with Prof James Steele after attending the 20th Annual James Steele lecture/ 99th birthday Dinner of Professor James Steele 4th and 6th April 2012 at the Texas School of Public Health, Houston, Texas, USA. The interview ...

  10. "Friending" Professors, Parents and Bosses: A Facebook Connection Conundrum

    Science.gov (United States)

    Karl, Katherine A.; Peluchette, Joy V.

    2011-01-01

    The ever-growing popularity of Facebook has led some educators to ponder what role social networking might have in education. The authors examined student reactions to friend requests from people outside their regular network of friends including professors, parents, and employers. We found students have the most positive reactions to friend…

  11. Humor and the Emeritus Professor: An Interview with Gene Roth

    Science.gov (United States)

    Vivona, Brian

    2015-01-01

    This essay is a compilation of several conversations with Dr. Gene Roth, Distinguished Teaching Professor Emeritus at Northern Illinois University. Dr. Roth is past President of the Academy of Human Resource Development, and although he is well known for his efforts in bringing humor into the field of HRD, he is not the same Gene Roth that played…

  12. Understanding the Motivation and Transformation of White Culturally Responsive Professors

    Science.gov (United States)

    Jenkins, China; Alfred, Mary

    2018-01-01

    The purpose of this study was to examine the motivation for White professors in higher education to become culturally inclusive in their teaching practices and the transformational experiences that created this motivation and shaped their development. The findings revealed personal convictions that centred on moral obligations towards teaching was…

  13. Häbi, professor, teil on Gefilus kapis / Eve Kruuse

    Index Scriptorium Estoniae

    Kruuse, Eve,d1959-

    2008-01-01

    Tartu Ülikooli professor Marika Mikelsaar võitis läinud kuul koos kolleegidega (Tiiu Kullisaar, Epp Songisepp, Hedi Annuk ja Mihkel Zilmer) Soulis ülemaailmse naisleiutajate konkursil ME-3 bakteri avastamise ja probiootikuks arendamise eest kuldmedali

  14. The Life of the Mind: A Tribute to Three Professors.

    Science.gov (United States)

    Yamamoto, Kaoru

    2000-01-01

    This speech by a distinguished scholar in educational psychology recounts, with appreciation, his educational experiences under three distinguished professors: Toshio Maki, his undergraduate thesis supervisor in Japan; E. Paul Torrance, the prominent educational psychologist; and C. Gilbert Wrenn, his doctoral advisor. (DB)

  15. University Professors and Teaching Ethics: Conceptualizations and Expectations

    Science.gov (United States)

    Dean, Kathy Lund; Beggs, Jeri Mullins

    2006-01-01

    After the spectacular ethical breaches in corporate America emerged, business school professors were singled out as having been negligent in teaching ethical standards. This exploratory study asked business school faculty about teaching ethics, including conceptualizations of ethics in a teaching context and opinions of the extent to which…

  16. Florida Tech professor gets three-year grant

    CERN Multimedia

    2003-01-01

    "Dr. Marc Baarmand, Florida Tech associate professor of physics, has received a three-year grant from the U.S. Department of Energy's Division of High Energy Physics, to conduct research with the Compact Muon Solenoid experiment" (1/3 page).

  17. Formação de professores com base na lei 10639/03 cultura africana e o legado de eduardo mondlane nos dias atuais

    Directory of Open Access Journals (Sweden)

    Nilce Silva

    2016-02-01

    Full Text Available Segundo Libâneo (2003 deve-se levar em conta para a formação de professores um apanhado de estudos considerados no contexto social, econômico, político e cultural no qual ele está inserido, visto que o exercício profissional docente está sempre relacionado aos fins e às práticas do sistema escolar mais amplo e ao contexto social.  Nesse contexto, merece atenção os chamados “velhos problemas” em relação à formação de professores, que evidenciam desarticulações em diferentes níveis, sendo considerado como o mais preocupante deles, a desarticulação entre teoria e prática, entre o discurso e a ação, o que se configura de grande gravidade no tocante às questões raciais no Brasil.  Sendo assim, vale ressaltar a importância da formação desses profissionais na construção de um currículo que contemple as novas demandas da sociedade brasileira, hoje voltadas para a promoção da equidade social e a atenção para a diversidade cultural. A conseqüência imediata disso é a necessidade de construção teórica de um currículo crítico (APPLE, 1982; GIROUX, 1986; FREIRE & SHOR, 1997, que possibilite ao professor o resgate da cultura que o aluno é portador e não se limite apenas a prescrever o que deve ser ensinado.

  18. CURRÍCULO PSICAGÓGICO NOS DISCURSOS MIDIÁTICOS: UM LUGAR DE TRANSFORMAÇÃO DAS SUBJETIVIDADES DE PROFESSORES

    Directory of Open Access Journals (Sweden)

    Carmen Brunelli de Moura

    2011-03-01

    Full Text Available A ideia de programar ações de melhoria na qualidade do ensino levou o Estado a dividir com a mídia os espaços de formação de professores. Isso fez surgir uma discursividade cujos efeitos apontam para um currículo pedagógico que funciona em meio a um conjunto de verdades e equipa o professor com uma teoria voltada para a profissionalidade e conduta do outro. Diante de todo esse profissionalismo, é possível entrever uma teoria da pessoalidade? É possível descrever um currículo cujos efeitos apontam para a transformação das subjetividades do professor e não apenas para sua formação? A partir desses questionamentos, objetivo descrever como os discursos da mídia problematizam a subjetividade do professor, pensando-a a partir de um currículo psicagógico, cujas verdades não têm como finalidade formar, mas transformar o modo de ser do professor. Para problematizar esse currículo psicagógico, tomo o discurso produzido na edição de Dezembro/2001, da Revista Nova Escola. Conduzo este estudo a partir do campo da Linguística Aplicada com idéias que vêm das noções desenvolvidas por Michel Foucault, além de conceitos colhidos entre pesquisadores como Antonio Nóvoa, Stephen Ball, Alfredo Veiga-Neto, Tomas Tadeu da Silva, Zigmunt Bauman e outros. Os resultados desse estudo apontam que a mídia, ao pensar um currículo psicagógico, propicia ao professor espaços de liberdade diante das pressões sociais e históricas e a apreensão de subjetividades mais autônomas, singulares, mais abertas às mudanças que se apresentam continuamente na liquidez da modernidade.

  19. Communications and Informational Technologies: professional preparation of the Informatics professor

    Directory of Open Access Journals (Sweden)

    Adrian Robaina Valdés

    2017-09-01

    Full Text Available The development of the society it is sign by the development of the techniques and the science that has challenges the educational system in the formation of the new generation. The Cuban Educational politics had defined the social mission to each subsystem of education, in the particular case of the professional polytechnic education, belongs to the professors of Informatics, the accomplish of this mission, develop an important role in the educational use of the communication and informational technologies that requires and an adequate professional preparation. The aim of this article is to based form the theoretical and methodological point, the process of the professional preparation of the professors of informatics in the technical schools while they apply the communication and informational technologies, the theorical bases offered the historical past and tendencies of the professional preparation while they apply the communication and information technologies, the educative use of information technologies in the pedagogical process and the theoretical support in this process, using revision methods bibliography and systematizing . We may say that the research work concludes that the preparation of the professors had passed for different stages that had point to the need of the formation of professor to give answers to the introduction of the informatics subject at school, using different ways, the postgraduate updates and all the variety of ways to upgrade the professors will use. Form the educative point of view a part from the study as a subject must be use as an intermediate in the pedagogical process, also, to determine the characteristic that distinguish the professional preparation process.

  20. African Journals Online: Curaçao

    African Journals Online (AJOL)

    ... Cambodia, Cameroon, Canada, Cayman Islands, Central African Republic, Chad, Chile, China, Colombia, Comoros, Congo, Democratic Republic, Congo, Republic, Costa Rica, Côte d'Ivoire, Croatia, Cuba, Curaçao, Cyprus, Czech Republic, Denmark, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, Arab Rep.

  1. Nemerteans from Curaçao

    NARCIS (Netherlands)

    Corrêa, Diva Diniz

    1963-01-01

    All species treated in this paper were collected by me between January and June 1962, during my stay at the “Caraïbisch Marien-Biologisch Instituut” (Caribbean Marine Biological Institute), Curaçao. I am deeply indebted to the Government of the Netherlands, which awarded me a grant enabling me to

  2. SIG aplicado ao Ensino de Geografia

    OpenAIRE

    Dornelles, Liane Maria Azevedo; Universidade do Estado do Rio de Janeiro - UERJ

    2009-01-01

    Este trabalho descreve as atividades desenvolvidas junto à disciplina eletiva SIG aplicado ao ensino de Geografia. Foram elaboradas aplicações ambientais para os Ensinos Fundamental e Médio, com auxílio dos programas VistaSAGA/UFRJ, SISPLAMTE 5as com GIS, SPRING/INPE e MapServer.

  3. Turbellaria from Curaçao

    NARCIS (Netherlands)

    Marcus, Ernst

    1960-01-01

    A study of the several fresh and brackish-water springs on Curaçao, carried out by Dr. P. WAGENAAR HUMMELINCK, revealed (a) the common occurrence on that island of Dugesia festai (Borelli 1898), a species which until then had only been known from the South American mainland (nearest find: Ecuador!),

  4. Estados Unidos: do Iraque ao Brasil

    Directory of Open Access Journals (Sweden)

    Virgílio Caixeta Arraes

    2010-12-01

    Full Text Available O presente artigo busca analisar os recentes temas recorrentes na política externa norte-americana, caracterizada pela “guerra contra o terror”, e seus impactos para a agenda a ser discutida na vindoura visita do presidente dos Estados Unidos, Geoge W. Bush, ao Brasil.

  5. Expressões Aritméticas: Crenças, Concepções e Competências no entendimento do Professor Polivalente

    OpenAIRE

    Arrais, Ubiratan Barros

    2006-01-01

    O presente trabalho teve por objetivo identificar e analisar as crenças, concepções e competências que os professores de 1ª a 4ª séries do Ensino Fundamental têm ao lidar com expressões aritméticas. Pesquisamos neste estudo a compreensão de uma classe particular de situações-problema que aqui chamamos de problemas de Estruturas Mistas. Nestes problemas temos Estrutura Aditiva e Estrutura Multiplicativa ocorrendo concomitantemente. A sentença matemática que representa um prob...

  6. Características clínico-comportamentais de professores . universitários no sertão paraibano

    OpenAIRE

    Coêlho, Raimunda de Fátima Neves

    2013-01-01

    p. 1-153 comprometer a saúde física e mental dos indivíduos é necessária, para respaldar programas de suporte ao docente. O estudo objetivou descrever características clínico-comportamentais de professores universitários no sertão paraibano, tendo como objetivos secundários: avaliar correlação entre Resiliência, História de Trauma, Transtorno do Estresse Pós-traumático - TEPT, Impulsividade, Religiosidade, e Qualidade de Vida na população estudada; determinar a frequência de...

  7. Ensino de Genética e materiais didáticos na formação inicial de professores

    OpenAIRE

    Klautau-Guimarães, Maria de Nazaré; Marzullo Pedreira, Mariana; de Oliveira, Silviene Fabiana

    2013-01-01

    Esse trabalho apresenta a análise de dois materiais didáticos, desenvolvidos para a visualização e facilitação no processo de ensino e aprendizagem de conteúdos básicos de genética para professores em formação inicial. Foram estabelecidas seis metas de aprendizagem e os materiais se mostraram adequados para a compreensão da maioria destas. Entretanto, adequações no tempo para o desenvolvimento das atividades e na adequação para a meta de maior dificuldade de compreensão, que foi quanto aos pr...

  8. Currículo e formação de professores: uma visão integrada da construção do conhecimento profissional

    OpenAIRE

    Felício, Helena Maria dos Santos; Silva, Carlos M.

    2017-01-01

    Este trabalho tem por objetivo analisar os aspectos da perspectiva integrada de currículo na formação inicial de professores do Brasil. Fundamentados no modelo de “currículo formativo integrado”, realizamos a análise documental dos Projetos Pedagógicos dos Cursos de Pedagogia de Universidade Federais Brasileiras para compreender quais e como os componentes do modelo integrado de formação estão presentes nesses documentos. Os resultados evidenciam: Em relação ao referencial de formação, os pro...

  9. Retextualização da escrita por alunos com surdez usuários de libras: em foco a mediação do professor

    Directory of Open Access Journals (Sweden)

    Claudia Regina Mosca Giroto

    2011-02-01

    Full Text Available Assume especial importância o modo como o professor mediará o processo de apropriação da escrita, ao compartilhar seus conhecimentos com o aluno com surdez, ao atribuir importância e sentidos ao que esse aluno foi capaz de produzir, ainda que sua produção não tenha se assemelhado ao padrão idealizado de escrita do adulto. Sob tais aspectos, este estudo se propôs investigar a mediação em atividades de retextualização, junto a alunos com surdez, realizada por oito alunos estagiários de um curso de Pedagogia, com idade entre 20 e 28 anos. Para tal, essas atividades foram registradas em vídeo, para posterior transcrição e análise descritiva, subsidiada por um modelo diagramático proposto pela literatura. Os resultados indicaram: a importância da retextualização na compreensão dos conteúdos escritos produzidos por alunos com surdez, a mudança atitudinal dos participantes acerca de seu papel como mediador e interlocutor em atividades dessa natureza e a maior compreensão, por parte do professor, acerca de aspectos notacionais e discursivos envolvidos na produção escrita de alunos com surdez. Tais resultados permitiram concluir a necessidade de os futuros professores, que trabalharão em classes inclusivas ou em classes multifuncionais, compreenderem e utilizarem as atividades de retextualização em sua prática pedagógica cotidiana para a promoção da apropriação do português escrito pelo aluno com surdez, usuário da LIBRAS. Cabe ressaltar a necessidade de esses professores conhecerem a gramática da LIBRAS, bem como terem acesso a conhecimentos lingüísticos que lhes permitam compreender a natureza das ocorrências presentes nos textos produzidos por alunos com surdez.

  10. Inclusão digital de professores nas escolas públicas da região metropolitana de Belém

    Directory of Open Access Journals (Sweden)

    Dayvid Gomes Vital Fares

    2016-02-01

    Full Text Available Este artigo traz algumas contribuições, de cunho teórico, a respeito da inclusão digital de docentes e gestores nas escolas de Belém, e as dificuldades que os mesmo encontram para utilizar a tecnologia da informação e comunicação no ambiente estudantil. Aborda sobre a infraestrutura computacional adquirida por projetos governamentais e faz uma alusão a dificuldade dos professores em relação a formação relacionada ao uso das tecnologias.

  11. Perfil dos Professores de Ensino Fundamental sobre Dificuldade Visual/ Profile of Elementary School Teachers about Visual Impairment.

    Directory of Open Access Journals (Sweden)

    Mariana Garcia Lopes Arena

    2013-06-01

    Full Text Available Objetivos: Verificar os conhecimentos e ações desenvolvidas por professores que atuam com alunos do ensino fundamental em relação aos sinais e sintomas indicativos de dificuldades visuais, analisando suas condutas diante do problema. Materiais e métodos: Realizou-se levantamento entre professores da primeira série do ensino fundamental de escolas públicas, estaduais e municipais, do município de Itajubá - MG, no ano letivo de 2013. Foi utilizado questionário autoaplicável como instrumento de coleta de dados. Resultados e discussão: Todos os 21 professores de escolas públicas responderam o questionário. A média de idade foi de 40,9 anos e a média de magistério, de 20,3 anos. Quanto à formação profissional, a maioria não apresenta capacitação na área (90,5%. Em relação aos sinais e sintomas de dificuldade visual, os mais indicados foram dificuldade para ler na lousa (100%, dor de cabeça (95,2%, franzir a testa (90,5% e aproximação exagerada de objetos e livros (90,5%. Dentre os professores, 80,9% indicaram ter tido algum aluno com dificuldade visual no último ano, enquanto 19,1% não suspeitaram. Entre os professores que indicaram ter algum aluno com dificuldade visual, 88,2% tiveram como conduta orientar os pais, 70,6% orientou procurar um oftalmologista, 58,8% orientaram a direção e somente 23,5%, orientaram o aluno. Conclusão: Apesar dos professores apresentarem algum conhecimento sobre a saúde ocular, estes ainda são insuficientes e suas ações são incompletas. Objectives: The study aims to determine the knowledge and actions developed by teachers working with elementary students for signs and symptoms which may show visual difficulties, analyzing the behaviors of teachers on the issue. Methods: We conducted a survey among first grade teachers of public state and city schools, in the city of Itajubá - MG, in the year of 2013. Self-administered questionnaire was used as an instrument for data collection

  12. Maury Nussbaum reappointed as Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Maury Nussbaum, professor of industrial and systems engineering in the College of Engineering at Virginia Tech, has been reappointed as the Hal G. Prillaman Professor Fellow in Industrial and Systems Engineering by the Virginia Tech Board of Visitors.

  13. Brian M. Kleiner receives Ralph H. Bogle Professor Fellowship in Industrial and Systems Engineering

    OpenAIRE

    Owczarski, Mark

    2010-01-01

    Brian M. Kleiner, professor of industrial and systems engineering in the College of Engineering at Virginia Tech, has been named the Ralph H. Bogle Professor Fellow in Industrial and Systems Engineering by the Virginia Tech Board of Visitors.

  14. Yue Joseph Wang named Grant A. Dove Professor of Electrical and Computer Engineering

    OpenAIRE

    Owczarski, Mark

    2009-01-01

    Yue Joseph Wang, professor of electrical and computer engineering in the College of Engineering at Virginia Tech, has been named the Grant A. Dove Professor of Electrical and Computer Engineering by the Virginia Tech Board of Visitors.

  15. Ser professor de Língua Inglesa em cursos livres: identificações e práticas docentes

    OpenAIRE

    Martins, Maria Waleska Siga Peil

    2014-01-01

    Adapte-se ou fique para trás parece ser a ordem do dia na sociedade pós-moderna e estar pronto para mudanças passa a ser requisito em um mundo relativamente estável. É a partir dessas constatações que se traz a discussão para o âmbito educacional, mais especificamente, ao campo do ensino de língua inglesa. Quem é o professor de inglês da pós-modernidade e como este se representa diante das várias possibilidades entre o ser e o estar? Uma pesquisa sobre identidade voltada para ...

  16. Para pensar sobre a formação continuada de professores é imprescindível uma teoria crítica de formação humana

    Directory of Open Access Journals (Sweden)

    Clarissa Martins de Araújo

    Full Text Available A formação continuada de professores na década de 1990 passou a ser considerada uma das estratégias fundamentais para o processo de construção de um novo perfil profissional do professor. Neste contexto, a concepção crítico-reflexiva foi defendida como a orientação mais adequada para a renovação dos sistemas de formação continuada de professores no Brasil. No entanto, ao longo de duas décadas, diferentes estudos indicam que esta orientação teórico-metodológica operou mudanças pouco significativas nas práticas formativas. A partir de uma revisão sobre a tendência denominada de Epistemologia da Prática, este ensaio propõe um deslocamento da formação continuada de professores do campo das políticas públicas para o campo da formação humana. Nesta direção, procuramos apontar qual a contribuição da teoria crítica da formação humana para os processos de formação continuada de professores na contemporaneidade.

  17. Concepções de polivalência e professor polivalente: uma análise historico‐legal

    Directory of Open Access Journals (Sweden)

    Shirleide Pereira da Silva Cruz

    2017-12-01

    Full Text Available As concepções de polivalência e professor polivalência são resultantes de um processo histórico relacionadas à visão de educação, escola, conhecimento e formação profissional. Assim, o texto descreve, a partir de alguns documentos oficiais educacionais, tal processo no período de 1970 até as reformas pós anos 1990. Percebe a noção de polivalência e professor polivalente associada a um sentido generalista e superficial de trato com os conteúdos curriculares denotando uma relação economicista de relação “custo‐benefício” sob a justificativa de se suprir o déficit de professores para atuarem na crescente população escolar com ensino obrigatório estendido no período militar. Após as reformas dos anos 90 os documentos dão indícios de uma lógica das competências tanto como conteúdo formativo profissional como modo de construção do conhecimento por parte dos sujeitos. Tais documentos referendam ainda uma noção de conhecimento baseada numa perspectiva de interdisciplinaridade um tanto frágil quando esta é transposta do contexto epistemológico para o contexto educacional e pedagógico o que fragiliza também, uma compreensão apolítica de competências aos processos de profissionalização docente reforçando uma lógica de responsabilização.

  18. Evolução do perfil didático-pedagógico do professor-engenheiro

    Directory of Open Access Journals (Sweden)

    André Luiz Molisani

    2016-09-01

    Full Text Available Resumo Este trabalho é uma revisão bibliográfica, cujos objetivos são analisar e compreender a evolução do perfil didático-pedagógico do professor-engenheiro no Brasil. Identificou-se que o perfil didático-pedagógico não mudou ao longo da história dos cursos de engenharia. O método de ensino-aprendizagem é caracterizado por práticas tradicionais, que envolvem aulas expositivas e práticas laboratoriais, sendo o aluno avaliado por provas. Analogamente, o parque industrial brasileiro não apresentou mudanças significativas ao longo da história, sendo caracterizado pela reprodução de bens de consumo. Entretanto, o mercado empregador brasileiro impõe uma formação técnico-científica baseada em uma visão ética e humanística, que possibilite entender e desenvolver novas tecnologias, adquirir senso crítico e criativo, além de identificar e resolver problemas e demandas da sociedade. Essas competências profissionais são observadas apenas em países desenvolvidos que possuem uma educação de nível superior globalizada, que prioriza a mobilidade internacional de estudantes, professores e profissionais. Isso significa que as referidas competências são incompatíveis com a realidade brasileira que não pratica inovação tecnológica, centrando-se na reprodução de manufaturados. O governo tem implantado tanto legislações educacionais como programas de auxílio às indústrias com o intuito de atender às demandas do mercado empregador. Entretanto, os resultados foram insatisfatórios devido ao perfil reprodutivo do setor industrial. Contudo, o docente precisa adquirir novos métodos de ensino-aprendizagem, que possibilitem a construção ao invés da reprodução do conhecimento. Objetiva-se melhorar a aprendizagem do aluno, aprimorando sua capacitação profissional, o que resulta em avanço tecnológico, mesmo que seja no âmbito da reprodução de manufaturados.

  19. Evolução do perfil didático-pedagógico do professor-engenheiro

    Directory of Open Access Journals (Sweden)

    André Luiz Molisani

    Full Text Available Resumo Este trabalho é uma revisão bibliográfica, cujos objetivos são analisar e compreender a evolução do perfil didático-pedagógico do professor-engenheiro no Brasil. Identificou-se que o perfil didático-pedagógico não mudou ao longo da história dos cursos de engenharia. O método de ensino-aprendizagem é caracterizado por práticas tradicionais, que envolvem aulas expositivas e práticas laboratoriais, sendo o aluno avaliado por provas. Analogamente, o parque industrial brasileiro não apresentou mudanças significativas ao longo da história, sendo caracterizado pela reprodução de bens de consumo. Entretanto, o mercado empregador brasileiro impõe uma formação técnico-científica baseada em uma visão ética e humanística, que possibilite entender e desenvolver novas tecnologias, adquirir senso crítico e criativo, além de identificar e resolver problemas e demandas da sociedade. Essas competências profissionais são observadas apenas em países desenvolvidos que possuem uma educação de nível superior globalizada, que prioriza a mobilidade internacional de estudantes, professores e profissionais. Isso significa que as referidas competências são incompatíveis com a realidade brasileira que não pratica inovação tecnológica, centrando-se na reprodução de manufaturados. O governo tem implantado tanto legislações educacionais como programas de auxílio às indústrias com o intuito de atender às demandas do mercado empregador. Entretanto, os resultados foram insatisfatórios devido ao perfil reprodutivo do setor industrial. Contudo, o docente precisa adquirir novos métodos de ensino-aprendizagem, que possibilitem a construção ao invés da reprodução do conhecimento. Objetiva-se melhorar a aprendizagem do aluno, aprimorando sua capacitação profissional, o que resulta em avanço tecnológico, mesmo que seja no âmbito da reprodução de manufaturados.

  20. Periodontitis determining the onset and progression of Huntington's disease: review of the literature

    Directory of Open Access Journals (Sweden)

    María Lourdes Rodríguez Coyago

    2015-10-01

    Full Text Available La enfermedad de Hungtinton es un trastorno neurodegenerativo, causado por la expansión de un triplete de citosina, adenina, guanina en el gen de la huntingtina. Se manifiesta con un deterioro físico, cognitivo y psiquiátrico a distintas edades en el adulto, con un pronóstico fatal. Además del número de repeticiones del triplete, existirían otros factores que explicarían el inicio de esta enfermedad a más temprana edad. Se sabe que la neuroinflamación es un protagonista en los trastornos neurodegenerativos, no siendo la enfermedad de Huntington una excepción. La neuroinflamación exacerba el daño neuronal producido por la mutación, al existir activación aberrante de la célula microglía, disfunción de astrocitos y células dendríticas; compromiso de la barrera hematoencefálica y activación de complemento, todas ellas como efecto directo e indirecto de la mutante y otros estímulos como infecciones crónicas. Es el interés del presente trabajo analizar la periodontitis, como modelo de infección bucodental crónica y fuente de inflamación sistémica. Hipotetizamos que el potencial rol de la periodontitis en la enfermedad de Huntington y los mecanismos por los cuales contribuiría a la manifestación temprana y progreso de dicha enfermedad, para lo cual se consideraron revisiones sistemáticas, metanálisis y estudios experimentales publicados tanto en español como en inglés obtenidos del PubMed y SciELO. Son diversos los mecanismos que generan inflamación en el cerebro de estos pacientes, adquiriendo especial protagonismo los mecanismos de la inmunidad innata. Las infecciones buco dentarias crónicas, como la enfermedad periodontal, pueden constituir un factor exacerbante de la neuroinflamación que per se asocia la enfermedad de Huntington.