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Sample records for ao lenho mole

  1. Métodos de delimitação dos lenhos juvenil e adulto de três folhosas e propriedades biométricas de suas fibras

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    Rafael de Avila Delucis

    2014-10-01

    Full Text Available Diante da importância do conhecimento das respectivas regiões do lenho juvenil e adulto para a indústria de base madeireira, este estudo foi realizado com o objetivo de delimitar, por meio das metodologias de retas de regressão e do incremento anual, as regiões dos lenhos juvenil e adulto das madeiras de açoitacavalo, nogueira-pecã e plátano. O parâmetro anatômico utilizado nas delimitações foi o comprimento de fibra. Adicionalmente, foram medidas outras propriedades anatômicas: diâmetro de fibra, diâmetro de lume e espessura de fibra. As propriedades das fibras foram descritas estatisticamente em razão da diferenciação entre os lenhos proposta em cada metodologia, a fim de comparação. Conforme os métodos das retas de regressão e do incremento anual, as idades de segregação entre os lenhos foram de 21 e 19 anos para a madeira de açoitacavalo e 16 e 14 anos para a madeira de nogueira-pecã. Para a madeira de plátano, ambas as metodologias definiram que o lenho segregou com 14 anos. Pode-se verificar que não houve distinção entre os resultados obtidos com as duas metodologias de delimitação dos lenhos juvenil e adulto, exceto quanto ao comprimento de fibras do lenho juvenil. O método do incremento anual foi considerado preferencial, em razão da fonte de erro verificada no método das retas de regressão.

  2. Moles (Nevi)

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    ... resources Meet our partners Español Donate Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ... growths Moles public SPOT Skin Cancer™ Diseases and treatments Acne and rosacea Bumps and growths Keratosis pilaris Moles Seborrheic keratoses ...

  3. Hydatidiform mole

    Science.gov (United States)

    ... hands , or unexplained weight loss Symptoms similar to preeclampsia that occur in the first trimester or early ... always a sign of a hydatidiform mole, because preeclampsia is extremely rare this early in a normal ...

  4. Anatomia ecológica do lenho stryphnodendron adstringens (mart.) Coville (leguminosae), barbatimao, no Parque Estadual do Cerrado - Jaguariaíva-PR

    OpenAIRE

    Montefusco, Ana Raquel Gomes

    2013-01-01

    A anatomia ecológica identifica a influência de fatores ambientais expressos nas características anatômicas e morfológicas das plantas, sendo definida como a relação entre a estrutura da planta e o ambiente. Nesse trabalho, objetivou-se estudar a anatomia ecológica da espécie Stryphnodendron adstringens (Mart.) Coville, Leg. No Parque Estadual do Cerrado, ao longo de uma topossequência, caracterizando e comparando os elementos anatômicos da estrutura do lenho (diâmetro tangencial dos vasos, c...

  5. Variação estrutural quantitativa no lenho de Terminalia ivorensis A. Chev., Combretaceae

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    Urbinati Cláudia V.

    2003-01-01

    Full Text Available Com o objetivo de analisar a variação anatômica ao longo do caule de Terminalia ivorensis, estudaram-se amostras de madeira de três indivíduos, nos planos radial e axial. Para tal, corpos de prova foram obtidos a partir de discos de madeira, de 2 em 2cm, no sentido medula-câmbio. A metodologia usada para desenvolver o trabalho foi aquela tradicionalmente recomendada para estudos em anatomia vegetal. A descrição anatômica realizada seguiu as recomendações do IAWA Committee. No sentido radial do caule, alguns elementos anatômicos apresentaram tendências de variação definidas e significativas estatisticamente quando aplicado o teste Tukey para comparação de médias. São eles: freqüência, diâmetro e comprimento dos elementos de vaso, freqüência de raios/mm linear, comprimento dos raios em número de células, e comprimento e espessura da parede das fibras. Já no sentido axial, todas as variáveis analisadas não se mostraram estatisticamente significativas. Os resultados observados devemse, principalmente, à caracterização bem definida dos lenhos juvenil e adulto na madeira de Terminalia ivorensis.

  6. Desrama, crescimento e predisposição à podridão-do-lenho em Acacia mangium Pruning on growth and heartrot predisposing in Acacia mangium

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    Helio Tonini

    2006-07-01

    Full Text Available A desrama é um procedimento que aumenta o valor e a qualidade da madeira. Entretanto, se realizada de forma inadequada pode reduzir o crescimento e constituir fator de predisposição à podridão-do-lenho. O objetivo deste trabalho foi estudar o efeito da intensidade e época da desrama sobre o crescimento inicial e incidência de árvores com ferimentos não cicatrizados de Acacia mangium. Foi instalado um experimento em delineamento de blocos ao acaso, com três repetições e cinco tratamentos: testemunha (sem desrama; desrama de troncos múltiplos e galhos a 50 e 70% da altura, em época de baixa e alta pluviosidade. As avaliações de crescimento e presença de ferimentos não cicatrizados foram feitas seis meses depois da aplicação dos tratamentos. A época e a intensidade de desrama, quando efetuadas aos 8 e 13 meses, não afetaram o crescimento em diâmetro e altura. Houve boa cicatrização de ferimentos em árvores desramadas oito meses depois do plantio, em época de baixa pluviosidade, independentemente da intensidade. Árvores desramadas aos 13 meses depois do plantio, em época de alta pluviosidade, demonstraram predisposição à podridão-do-lenho.Pruning increases quality and economic value of the wood. Inadequate pruning procedures, however, interfere negatively on growth and consist on a predisposing factor to heartrot. The objective of this work was to investigate the effect of intensity and season of pruning on initial growth and on incidence of Acacia mangium trees with non-occluded wounds. The experimental design was in randomized blocks with three replicates and five treatments: control (without pruning; pruning and singling at 50 and 70% of total height, in low and high precipitation season. Growth evaluations and the presence of non-occluded wounds were performed six months after treatments application. The season and intensity of pruning operations did not influence height and diameter growth. Efficient wound

  7. Anatomia do lenho de Raulinoa echinata R.S.Cowan (Rutaceae uma espécie endêmica. Wood anatomy of Raulinoa echinata R.S.Cowan (Rutaceae an endemic species.

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    Adriano Antonio DAROSCI

    2012-12-01

    Full Text Available A anatomia vegetal é útil para a caracterização das espécies e do ambiente em que estas vivem. Muitas espécies respondem a algumas características ambientais com alterações na anatomia do lenho, por exemplo, na quantidade de vasos e raios, o que contribui para a sobrevivência no ambiente. Outras respostas anatômicas do lenho, devido às condições fisiológicas-estruturais presentes em diferentes regiões do caule, também são comuns. O presente estudo analisou a anatomia do lenho de Raulinoa echinata, espécie endêmica da mata ciliar do Vale do Itajaí, a fim de buscar alterações do lenho em resposta a algumas características ambientais, além daquelas provocadas pelas diferentes regiões do caule. Para tanto, amostras do lenho foram coletadas em duas regiões: próxima do solo e à altura do peito (1,30 m. Possíveis respostas de R. echinata ao ambiente ripário foram observadas no comprimento e na frequência das fibras, na largura dos raios e no comprimento e na frequência total de vasos, com diferenças significativas, entre as duas regiões, apenas em características quantitativas. A espécie apresentou, ainda, vasos múltiplos tangenciais e em cacho, características até então não descritas para Rutaceae. Não foram vistos na espécie canais traumáticos, característica comum para Rutaceae. Plant anatomy is useful for the characterization of species and their associated environment. Many species, because of habitat features, can show anatomical alterations of wood that permit their survival in the environment, quantity of vessels and rays, for example. Other anatomical alterations caused by structural-physiological conditions present in different regions of the stem are also common. In this study, the anatomy of Raulinoa echinata wood, an endemic riparian forest species of Itajaí Valley, was analyzed in order to identify alterations in wood because of specific habitat features, as well as adaptations in different

  8. MOLES Information Model

    Science.gov (United States)

    Ventouras, Spiros; Lawrence, Bryan; Woolf, Andrew; Cox, Simon

    2010-05-01

    The Metadata Objects for Linking Environmental Sciences (MOLES) model has been developed within the Natural Environment Research Council (NERC) DataGrid project [NERC DataGrid] to fill a missing part of the ‘metadata spectrum'. It is a framework within which to encode the relationships between the tools used to obtain data, the activities which organised their use, and the datasets produced. MOLES is primarily of use to consumers of data, especially in an interdisciplinary context, to allow them to establish details of provenance, and to compare and contrast such information without recourse to discipline-specific metadata or private communications with the original investigators [Lawrence et al 2009]. MOLES is also of use to the custodians of data, providing an organising paradigm for the data and metadata. The work described in this paper is a high-level view of the structure and content of a recent major revision of MOLES (v3.3) carried out as part of a NERC DataGrid extension project. The concepts of MOLES v3.3 are rooted in the harmonised ISO model [Harmonised ISO model] - particularly in metadata standards (ISO 19115, ISO 19115-2) and the ‘Observations and Measurements' conceptual model (ISO 19156). MOLES exploits existing concepts and relationships, and specialises information in these standards. A typical sequence of data capturing involves one or more projects under which a number of activities are undertaken, using appropriate tools and methods to produce the datasets. Following this typical sequence, the relevant metadata can be partitioned into the following main sections - helpful in mapping onto the most suitable standards from the ISO 19100 series. • Project section • Activity section (including both observation acquisition and numerical computation) • Observation section (metadata regarding the methods used to obtained the data, the spatial and temporal sampling regime, quality etc.) • Observation collection section The key concepts in

  9. Histamine combined with melphalan in isolated limb perfusion for the treatment of locally advanced soft tissue sarcomas: preclinical studies in rats Histamina combinada ao melfalano na perfusão de membro isolado para o tratamento de sarcomas de partes moles localmente avançado: estudos pré-clínicos em ratos

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    Flavia Brunstein

    2005-08-01

    Full Text Available PURPOSE: To evaluate the potential benefit of histamine combined with melphalan in the isolated limb perfusion (ILP as an alternative to TNF-alfa and melphalan combination, for the treatment of irressectable soft tissue sarcomas of the limbs in Brown Norway (BN rats. METHODS: 20 BN rats had small fragments of syngeneic BN-175 fibosarcoma inserted on the right hind limb. In 7-10 days the tumor reached a median diameter of 12-15 mm and they were randomly divided in four groups (sham, melphalan, histamine and escalating doses of histamine combined to melphalan being submitted to experimental ILP for 30 minutes. Tumors were measured daily with a caliper and the volume was calculated. RESULTS: Response curves showed a significant effect of the combination of histamine 200 mg/mL with melphalan, with 66% overall response, including 33% complete responses (pOBJETIVO: Avaliar o potencial benéfico da histamina combinada ao melfalano, na perfusão de membro isolado (PMI, como alternativa à combinação TNF-alfa mais melfalano, no tratamento de sarcomas de partes moles irressecaveis em extremidades, em ratos de linhagem Brown Norway (BN. MÉTODOS: 20 ratos BN foram submetidos a implantação de fragmentos de fibrosarcoma singênico BN-175 na pata traseira direita. Em cerca de 7-10 dias o tumor atingiu um diâmetro médio de 12-15 mm e foram aleatóriamente divididos em quatro grupos (controle, melfalano, histamina em doses progessivas combinada ao melfalano e histamina sendo submetidos a PMI experimental por 30 minutos. Os tumores foram então medidos diariamente com o uso de paquímetro e o volume tumoral calculado. RESULTADOS: As curvas de resposta mostram um efeito significativo da combinação de Histamina na concentração de 200 mg/mL ao melfalano, com 66% de resposta global incluindo 33% de respostas completas (p < 0.01. Não houve efeitos colaterais sistêmicos e localmente apenas edema leve e transitório nos animais tratados com histamine

  10. Of Bushwahckers, Termites and Moles.

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    Smelter, Richard W.

    2003-01-01

    Retired school administrator describes five types of school personnel that make an administrator's job difficult: Bushwackers, termites, CIA moles, rumor-mill addicts, and sartorial slobs. For example, termites are staff members who purposely volunteer for committees so they can sabotage the group's efforts from within. (PKP)

  11. Moles

    Science.gov (United States)

    ... Derm App Skin Facts Aging and Sun Damage Beauty Myths Preventing Sun Damage Skin Cancer Detection Skin ... done where cancer is a reasonable concern. Improving cosmetic appearance is another reason for excision, but all ...

  12. Partial hydatidiform mole: ultrasonographic features.

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    Woo, J S; Hsu, C; Fung, L L; Ma, H K

    1983-05-01

    Four patients with partial hyatidiform mole managed at the Queen Mary Hospital, Hong Kong, are described. The diagnosis of blighted ovum or missed abortion was made on the sonographic findings prior to suction evacuation. The dominant features in these cases consisted of a relatively large central transonic area bearing the appearance of an empty gestational sac and surrounded by a thick rim of low-level placenta-like echoes; in contrast with the case of the blighted ovum, a well-defined echogenic sac wall is absent. In another 9 patients with molar pregnancy managed during the same period, the more typical 'snow-storm' vesicular appearance was present. It was concluded that the anembryonic appearance described should alert the sonologist and clinician to the possible diagnosis of partial hydatitiform mole. The evacuated material from the uterine cavity should be examined morphologically and if possible cytogenetically. PMID:6578773

  13. Tool to Distinguish Moles from Melanoma

    Science.gov (United States)

    Moles to Melanoma: Recognizing the ABCDE Features” presents photos that show changes in individual pigmented lesions over time, and describes the different appearances of moles, dysplastic nevi, and melanomas.

  14. Variação estrutural quantitativa no lenho de Terminalia ivorensis A. Chev., Combretaceae

    OpenAIRE

    Urbinati Cláudia V.; Azevedo Aristéa A.; Silva Eldo A. Monteiro da; Lisboa Pedro L. B.

    2003-01-01

    Com o objetivo de analisar a variação anatômica ao longo do caule de Terminalia ivorensis, estudaram-se amostras de madeira de três indivíduos, nos planos radial e axial. Para tal, corpos de prova foram obtidos a partir de discos de madeira, de 2 em 2cm, no sentido medula-câmbio. A metodologia usada para desenvolver o trabalho foi aquela tradicionalmente recomendada para estudos em anatomia vegetal. A descrição anatômica realizada seguiu as recomendações do IAWA Committee. No sentido radial d...

  15. Podridão-do-lenho em plantios homogêneos de Acacia mangium Heartrot in homogeneous stands of Acacia mangium

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    Bernardo de Almeida Halfeld-Vieira

    2006-04-01

    Full Text Available O objetivo deste trabalho foi relatar a ocorrência da podridão-do-lenho em plantios homogêneos de Acacia mangium no Estado de Roraima. A observação dos sintomas iniciais em ferimentos de poda indica que a desrama artificial é um fator de predisposição. Estimativas realizadas em dois talhões comerciais constataram cerca de 8 e 39% de incidência da doença em árvores de três anos. Isolamentos a partir de árvores sintomáticas e testes de patogenicidade demonstram que Lasiodiplodia theobromae pode contribuir no processo de podridão. Este é o primeiro relato da podridão-do-lenho em A. mangium no Brasil, o que pode limitar sua exploração comercial.The objective of this work was to report the occurrence of heartrot in homogeneous stands of Acacia mangium in the State of Roraima, Brazil. Observations of symptoms initiating from pruning wounds indicated that the artificial pruning is a predisposing factor. A survey carried out in two commercial stands showed 8 and 39% of disease incidence in three-year-old trees. Isolations performed from symptomatic trees and pathogenicity tests demonstrated that the fungus Lasiodiplodia theobromae can incite the rot development. This is the first record of A. mangium heartrot in Brazil. The disease can restrict its commercial exploration.

  16. Efeitos da poluiçao por petróleo na estrutura da folha e do lenho de Podocarpus lambertii Klotzsch ex Endl. (Podocarpaceae)

    OpenAIRE

    Maranho, Leila Teresinha

    2004-01-01

    Resumo: O presente estudo teve como objetivo investigar, por meio de parâmetros morfológicos, anatômicos e fisiológicos, o impacto da poluição por petróleo em Podocarpus lambertii Klotzsch ex Endl. (Podocarpaceae), espécie popularmente conhecida por pinheiro-bravo. P. lambertii foi selecionado, porque além de ser uma espécie nativa, apresentou um comportamento diferenciado dentre as demais espécies diante do derramamento de petróleo. Folhas e amostras de madeira de nove indivíduos (seis expos...

  17. CT findings of the Hydatidiform mole

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Kyung Sik; Yoo, Shi Joon; Chang, June Hong [Seoul District Armed Forces General Hospital, Seoul (Korea, Republic of)

    1984-09-15

    Even though ultrasonography is a primary tool for evaluation of gynecological pelvic mass, CT can be helpful when ultrasonography is suboptimal either because of abundant intestinal gas or marked obesity. Authors experienced 3 cases of hydatidiform mole demonstrated by CT. The findings of hydatidiform mole are enlargement of uterus, low density in the uterine cavity, irregular soft tissue mass with small multiple cyst, and strong contrast enhancement of the soft tissue mass within the uterine cavity. CT can be a useful diagnostic tool for differentiation of hydatidiform mole from choriocarcinoma because of good visualization of uterine wall and pelvic structures.

  18. Moles and Mole Control on British Farms, Amenities and Gardens after Strychnine Withdrawal

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    Baker, Sandra E.; Ellwood, Stephen A.; Johnson, Paul J.; Macdonald, David W.

    2016-01-01

    Simple Summary Moles are burrowing mammals that are regarded as pests in Britain, and until 2006 they could legally be killed using strychnine poison. When strychnine was withdrawn there were fears that mole populations would increase. We surveyed farmers, amenity managers and householders about moles and mole control on their land in 2007, post strychnine withdrawal. Kill-trapping was by far the preferred control method used and control may be used more than can be justified by damage levels or the effect of control on damage. Mole traps are unregulated, unlike most other spring traps, and some might not meet current welfare standards. We found no evidence that mole activity had increased since a 1992 survey of farms. Abstract Moles are considered pests in Britain, but this issue has been little studied. Lower welfare standards have been tolerated for moles than for most other managed wild mammal species, as use of both the controversial poison, strychnine, and unregulated traps have been permitted. Strychnine was withdrawn in 2006 and there were fears that mole populations would increase as a result. In 2007, we conducted a comprehensive, nationwide survey of land manager perceptions, opinions and behaviour regarding moles and mole control on farms, amenities and domestic gardens in Britain. We surveyed 2150 land managers (achieving a 59% response rate) and ground-truthed 29 responses. Moles were reported to be present on most farms and amenities, and 13% of gardens, and were more common in lighter soils. Where present, moles were usually considered pests, this being more likely in Wales, Scotland and northern England, on livestock and mixed farms, and on large, high-value amenities, e.g., racecourses and golf courses. Mole control followed similar patterns to mole presence. More control may occur than is economically, and therefore potentially ethically, justified. Control should be more carefully considered and, where necessary, more effectively targeted. Kill

  19. Moles and Mole Control on British Farms, Amenities and Gardens after Strychnine Withdrawal

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    Sandra E. Baker

    2016-06-01

    Full Text Available Moles are considered pests in Britain, but this issue has been little studied. Lower welfare standards have been tolerated for moles than for most other managed wild mammal species, as use of both the controversial poison, strychnine, and unregulated traps have been permitted. Strychnine was withdrawn in 2006 and there were fears that mole populations would increase as a result. In 2007, we conducted a comprehensive, nationwide survey of land manager perceptions, opinions and behaviour regarding moles and mole control on farms, amenities and domestic gardens in Britain. We surveyed 2150 land managers (achieving a 59% response rate and ground-truthed 29 responses. Moles were reported to be present on most farms and amenities, and 13% of gardens, and were more common in lighter soils. Where present, moles were usually considered pests, this being more likely in Wales, Scotland and northern England, on livestock and mixed farms, and on large, high-value amenities, e.g., racecourses and golf courses. Mole control followed similar patterns to mole presence. More control may occur than is economically, and therefore potentially ethically, justified. Control should be more carefully considered and, where necessary, more effectively targeted. Kill-trapping was the favoured recent and future method on farms and amenities, even if strychnine was to be reintroduced; however, because mole traps are currently unregulated, some might not meet current welfare standards if tested. We found no evidence for an increase in moles since a farm questionnaire survey conducted in 1992; this could have wider implications for future wildlife management policy changes.

  20. Magnetic orientation in the giant mole-rat and the silvery mole-rat

    OpenAIRE

    OLIVERIUSOVÁ, Ludmila

    2008-01-01

    The magnetic orientation was study in several species of rodents. Aim of this work was verify magnetic sense in two species of subterranean rodents: the giant mole-rat and the silvery mole-rat. A spontaneous directional preference in the magnetic field was tested in circular arena.

  1. Brain Mass and Cranial Nerve Size in Shrews and Moles

    OpenAIRE

    Leitch, Duncan B.; Sarko, Diana K.; Catania, Kenneth C.

    2014-01-01

    We investigated the relationship between body size, brain size, and fibers in selected cranial nerves in shrews and moles. Species include tiny masked shrews (S. cinereus) weighing only a few grams and much larger mole species weighing up to 90 grams. It also includes closely related species with very different sensory specializations – such as the star-nosed mole and the common, eastern mole. We found that moles and shrews have tiny optic nerves with fiber counts not correlated with body or ...

  2. Caracterização e descrição da estrutura anatômica do lenho de seis espécies arbóreas com potencial medicinal Characterization and description of wood anatomical structure in six tree species with medicinal potential

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    G. Cury

    2011-01-01

    Full Text Available A caracterização morfoanatômica e a correta identificação das plantas medicinais são fundamentais para o controle de qualidade dos fitoterápicos. No presente trabalho é caracterizada a anatomia do lenho visando à identificação de seis espécies arbóreas com potencial medicinal. As amostras do lenho foram extraídas por método não destrutivo do tronco das árvores das espécies desenvolvidas em áreas de preservação. Em laboratório as amostras do lenho foram processadas para análises microscópicas do lenho, aplicando as metodologias para estudos de anatomia. Os resultados mostraram que o parênquima axial foi o parâmetro anatômico mais efetivo para a distinção das espécies através da análise do seu lenho. No trabalho discute-se a importância da aplicação da anatomia do lenho como ferramenta na identificação de espécies arbóreas medicinais.The morphoanatomical characterization and the correct identification of medicinal plants are fundamental for the quality control of phytotherapics. In the present work, wood anatomy was characterized in order to identify six tree species with medicinal potential. Wood samples were collected through a non-destructive method from the trunk of trees developed in conservation areas. In the laboratory, wood samples were processed for microscopic analysis by applying the methods for anatomical studies. Axial parenchyma was the most effective anatomical parameter to distinguish species through wood analysis. In this work, the importance of wood anatomy as a tool for the identification of medicinal tree species was discussed.

  3. Anatomia do lenho de Uncaria guianensis e U. tomentosa (Rubiaceae do estado do Acre, Brasil Wood anatomy of Uncaria guianensis e U. tomentosa (Rubiaceae from the State of Acre, Brazil

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    Percy A. Zevallos Pollito

    2006-01-01

    Full Text Available As plantas de Uncaria guianensis e U. tomentosa são lianas trepadeiras, arbustos trepadores ou rasteiros ascendentes que ocorrem em amplas áreas da Amazônia brasileira e países da América Central e do Sul. Possuem excepcional importância medicinal, com sua casca, lenho e folhas utilizadas pelos povos amazônicos e pela indústria farmacêutica. Face a necessidade da identificação das plantas em condições de campo e de laboratório, o presente trabalho descreveu a estrutura anatômica do lenho de Uncaria guianensis e U. tomentosa, ocorrentes no Estado do Acre, Brasil. Os resultados mostraram que o lenho das espécies é característico da família Rubiaceae, a exceção dos vasos arredondados, grandes e solitários, parenquima axial difuso e largura dos raios que são próprios das lianas.Uncaria guianensis and U. tomentosa are climbing lianas, bush lianas occuring in large areas of Brazilian Amazon and Central and South America countries. The species presented exceptional medicinal importance, with its bark, wood and leaves used by Amazon native people and pharmaceutical industries. Considering the importance of the species identification in field and laboratory conditions, the present work described the anatomical structure of Uncaria guianensis and U. tomentosa, which occurs in State of Acre, Brazil. The results showed that the wood of the species was characteristic of the Rubiaceae family, except the rounded vessel, greater and solitary, parenchyma axial diffuse and width of the rays, proper of lianas.

  4. Ossicular density in golden moles (Chrysochloridae).

    Science.gov (United States)

    Mason, Matthew J; Lucas, Sarah J; Wise, Erica R; Stein, Robin S; Duer, Melinda J

    2006-12-01

    The densities of middle ear ossicles of golden moles (family Chrysochloridae, order Afrosoricida) were measured using the buoyancy method. The internal structure of the malleus was examined by high-resolution computed tomography, and solid-state NMR was used to determine relative phosphorus content. The malleus density of the desert golden mole Eremitalpa granti (2.44 g/cm3) was found to be higher than that reported in the literature for any other terrestrial mammal, whereas the ossicles of other golden mole species are not unusually dense. The increased density in Eremitalpa mallei is apparently related both to a relative paucity of internal vascularization and to a high level of mineralization. This high density is expected to augment inertial bone conduction, used for the detection of seismic vibrations, while limiting the skull modifications needed to accommodate the disproportionately large malleus. The mallei of the two subspecies of E. granti, E. g. granti and E. g. namibensis, were found to differ considerably from one another in both size and shape. PMID:16944164

  5. Prevalence of Toxoplasma gondii in common moles (Talpa europaea)

    NARCIS (Netherlands)

    Krijger, I.M.; Cornelissen, J.B.W.J.; Wisselink, H.J.; Meerburg, B.G.

    2014-01-01

    Background The prevalence of Toxoplasma gondii in common moles, Talpa europaea, was investigated in order to determine whether moles can serve as an indicator species for T. gondii infections in livestock. Findings In total, 86 moles were caught from 25 different sites in the Netherlands. Five diffe

  6. PARTIAL HYDATIDIFORM MOLE WITH A LIVE FETUS: A RARE ENTITY

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    Mounika Reddy

    2015-07-01

    Full Text Available BACKGROUND : Gestational trophoblastic neoplasia (GTN represents a spectrum of premalignant and malignant diseases that occur after abnormal fertilization. [ 1 ] GTN includes complete hydatidiform mole (CHM, partial hydatidiform mole (PHM, invasive mole, choriocarcinoma, and placental - site trophoblastic tumor (PSTT. CHM and PHM together account for 80% of all cases of GTN.

  7. Invasive mole: a rare cause of postmenopausal bleeding

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    Mamour Guèye

    2013-06-01

    Full Text Available Gestational trophoblastic disease (GTD describes a number of gynaecological tumours that originate in the trophoblast layer, including hydatidiform mole (complete or partial, placental site trophoblastic tumour, choriocarcinoma and invasive mole. Invasive moles are responsible of most cases of localized gestational trophoblastic neoplasia (GTN. Invasive mole is a condition where a molar pregnancy, such as a partial hydatidiform mole or complete hydatidiform mole, invades the wall of the uterus. It is an extremely rare condition. As GTN is not considered in the differential diagnosis of postmenopausal uterine malignancies, its preoperative diagnosis is challenging. We report a case of invasive hydatidiform mole in a postmenopausal woman discovered in a context of postmenopausal bleeding. She underwent hysterectomy and followed up till her beta hCG levels were within normal limits. The patient is in complete remission in the first postoperative year. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000: 451-453

  8. Ultrasonographic findings of hydatidiform mole and missed abortion

    International Nuclear Information System (INIS)

    To establish the sonographic characteristics of the hydatidiform mole and the missed abortion with placental degeneration, we have retrospectively analyzed 12 cases of complete mole, 10 cases of partial mole, and 10 cases of missed abortion with placental hydropic degeneration, collected at Taegu Catholic General Hospital, from January 1986 to December 1989. The results were as follows : 1. Of 12 cases of complete mole, all demonstrated diffuse intrauterine vesicular pattern of internal echo without a gestational sac. Two cases were recurred after D and E. 2. The partial mole was characterized by focal (70%) or diffuse (20%) distribution of hydatidiform placental change and a gestational sac (100%) with or without a macerated fetus. But the striking hydatidiform placental change was not present in one cases of partial mole. 3. The uterus was larger for dates in 9 cases (90%) of complete mole, but smaller for dates in 7 cases (70%) of partial mole. 4. The missed abortion with placental hydropic degeneration was indistinguished from a partial mole due to their similar sonographic appearance : focal or diffuse cystic change of a placenta, a distorted gestational sac with or without a fetus, and a smaller uterus for dates. On conclusion, the complete mole could be easily distinguished from a partial mole or a missed abortion by sonography : a gestational sac or an area of noncystic placenta was not identified in a complete mole. The partial mole was indistinguished from a missed abortion, but if there is the suspicion of trophoblastic proliferation, such as a convex placental surface or a larger uterus for dates, then the diagnosis is probably a partial mole rather than a missed abortion

  9. Localized vibrations: moles in structure-land

    Science.gov (United States)

    van der Maas, John H.

    1992-03-01

    Functional groups reveal specific information about their direct surroundings; in fact, they form the moles, the undercover agents, in molecules. However, as with agents, the information is produced in coded form (spectral data) so one has to know the code in detail before the message is completely understood. The substantially improved accuracy (wavenumber, intensity) and sensitivity brought about by FT-instruments, in combination with computer software, offer extended spectral information. Functional groups can now be examined in great detail. Obviously the amount of deducible structural items is group dependent, implying that one has to pursue the probing qualities of a functionality prior to use. The OH-group, and more in particular the OH-stretching vibration, proves to be an extremely good mole. Its potentials are demonstrated on conformational studies of various saturated alcohols, the presence of OH(DOT)(DOT)(DOT)(pi) bridges, the strength and type of OH(DOT)(DOT)(DOT)O bridges, all in an apolar solvent, and on the disclosure of different hydrogen bonds in some solid samples.

  10. The risk of persistent trophoblastic disease after hydatidiform mole classified by morphology and ploidy

    DEFF Research Database (Denmark)

    Niemann, Isa; Hansen, Estrid S; Sunde, Lone

    2007-01-01

    OBJECTIVE: Hydatidiform mole can be classified by histopathologic characteristics and by genetic constitutions and most complete moles are diploid, whereas most partial moles are triploid. We investigated the concordance between these two classifications, characterized moles with conflicting clas...

  11. Moles: Tool-Assisted Environment Isolation with Closures

    Science.gov (United States)

    de Halleux, Jonathan; Tillmann, Nikolai

    Isolating test cases from environment dependencies is often desirable, as it increases test reliability and reduces test execution time. However, code that calls non-virtual methods or consumes sealed classes is often impossible to test in isolation. Moles is a new lightweight framework which addresses this problem. For any .NET method, Moles allows test-code to provide alternative implementations, given as .NET delegates, for which C# provides very concise syntax while capturing local variables in a closure object. Using code instrumentation, the Moles framework will redirect calls to provided delegates instead of the original methods. The Moles framework is designed to work together with the dynamic symbolic execution tool Pex to enable automated test generation. In a case study, testing code programmed against the Microsoft SharePoint Foundation API, we achieved full code coverage while running tests in isolation without an actual SharePoint server. The Moles framework integrates with .NET and Visual Studio.

  12. Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization

    OpenAIRE

    Zhou, Xi; Chen, Yongli; Li, Yongmei; DUAN, ZHAO

    2011-01-01

    In the present study, the case of a 34-year-old Chinese female who underwent in vitro fertilization resulting in a twin pregnancy was reported. Following in vitro fertilization, the patient was found to have a partial hydatidiform mole (PHM) with a co-existing twin by transvaginal sonography (TVS). At 16 weeks, the pregnancy was terminated and a normal-looking fetus with a HM placenta was delivered, in addition to a normal fetus with a normal placenta. Following termination of the pregnancy, ...

  13. CLINICAL PARTICULARITIES AND DIAGNOSTIC METHODS IN THE HYDATIDIFORM MOLE

    Directory of Open Access Journals (Sweden)

    Eduard Crauciuc

    2013-12-01

    Full Text Available Aim of this study was to establish a significant way to the prognosis improvement in trophoblastic pathologyin patients with hydatidiform mole. Objective. A mole is a particularity of embryonic development where a pregnancyoccurs paradoxically without an embryo (the mole pregnancy and develops only its placental tissue. It is important todemonstrate that the clinical diagnostic should always be completed by a histo-pathological diagnostic and also by thedescription of the natural history of the disease until the time of diagnostic. Material and method. The cases included inthe study (n=45 were hospitalized in ”Elena Doamna” Clinical Hospital Iaşi, in the period of time between 2008 and2013, and diagnosed with hydatidiform mole. The study was a retrospective one, case-control type. Starting from thealready diagnosed illness and following the clinical and paraclinical parameters outlined in literature, the objective of thestudy was to establish the main risk factors that trigger the molar pregnancy. Results. The epidemiological characteristicsshow the following main risk factors for a molar pregnancy: age over 30, urban area, tobacco and alcohol consumption.The mean values of βHCG decreased significantly after the hydatidiform mole was removed, from 26,624 to 9,859mUI/ml (p<0.05.Conclusions. Every woman with a history of hydatidiform mole has an increased risk of developingcarcinoma. After the complete or partial removal of the hydatidiform mole, it is necessary to monitor the values of βHCGtwice a month until they stabilize.

  14. Results of the mole penetration tests in different materials

    Science.gov (United States)

    Wawrzaszek, Roman; Seweryn, Karol; Grygorczuk, Jerzy; Banaszkiewicz, Marek; Rybus, Tomasz; Wisniewski, Lukasz; Neal, Clive R.; Huang, Shaopeng

    2010-05-01

    Mole devices are low velocity, medium to high energy, self-driven penetrators, designed as a carrier of different sensors for in situ investigations of subsurface layers of planetary bodies. The maximum insertion depth of such devices is limited by energy of single mole's stroke and soil resistance for the dynamic penetration. A mole penetrator ‘KRET' has been designed, developed, and successfully tested at Space Research Centre PAS in Poland. The principle of operation of the mole bases on the interaction between three masses: the cylindrical casing, the hammer, and the rest of the mass, acting as a support mass. This approach takes advantage of the MUPUS penetrator (a payload of Philae lander on Rosetta mission) insertion tests knowledge. Main parameters of the mole KRET are listed below: - outer diameter: 20.4mm, - length: 330mm, - total mass: 488g, - energy of the driving spring: 2.2J, - average power consumption: 0.28W, - average insertion progress/stroke: 8.5mm, The present works of Space Research Center PAS team are focused on three different activities. First one includes investigations of the mole penetration effectiveness in the lunar analogues (supported by ESA PECS project). Second activity, supported by Polish national fund, is connected with numerical calculation of the heat flow investigations and designing and developing the Heat Flow Probe Hardware Component (HPHC) for L-GIP NASA project. It's worth noting that L-GIP project refers to ILN activity. Last activity focuses on preparing the second version of the mole ready to work in low thermal and pressure conditions. Progress of a mole penetrator in granular medium depends on the mechanical properties of this medium. The mole penetrator ‘KRET' was tested in different materials: dry quartz sand (0.3 - 0.8 grain size), wet quartz sand, wheat flour and lunar regolith mechanical simulant - Chemically Enhanced OB-1 (CHENOBI). Wheat flour was selected due to its high cohesion rate and small grain size

  15. Association between Breus' mole and partial hydatidiform mole: chance or can hydropic villi precipitate placental massive subchorionic thrombosis?

    Science.gov (United States)

    Kim, Dae Tong; Riddell, D Christie; Welch, J Philip; Scott, Heather; Fraser, Robert B; Wright, James R

    2002-01-01

    Breus' mole (massive subchorionic hematoma) is a rare entity most often found in the placentae of macerated stillborn fetuses. Previously considered to represent a postmortem event, recent evidence suggests that it occurs prior to fetal demise. A 23-week gestation male neonate was delivered of a 23-year-old gravida 3, para 2 woman and survived for 49 min. An autopsy with chromosomal studies resulted in a diagnosis of triploidy. Placental examination showed the presence of both Breus' mole and also partial hydatidiform mole. DNA samples extracted from portions of the fresh hematoma and from the fetal spleen were compared using molecular techniques. PCR analysis showed the presence of Y chromosome specific DNA in the placental clot, but a semiquantitative Southern blot demonstrated that roughly 85% of the clot DNA was of maternal origin. These findings suggest that Breus' mole represents primarily maternal thrombosis rather than fetal hemorrhage. We hypothesize that the partial mole could have contributed to the formation of the Breus' mole as some of the hydropic villi may have focally obstructed the maternal venous return from the intervillus space causing sluggish flow and promoting thrombosis. A review of the literature on Breus' mole shows that the majority of reported cases have not included cytogenetic findings. However, several authors have reported an association with triploidy and other chromosomal anomalies characterized by scattered placental hydropic villi. Thus, we suggest that obstruction of maternal venous return by hydropic villi may have played a contributory role in some of these other reported cases. PMID:12396900

  16. Chromosomal evolution in rodents: the case of mole rats

    Czech Academy of Sciences Publication Activity Database

    Zima, Jan; Arslan, A.

    Lisbon: -, 2014. s. 44. [Rodens et Spatium /14./. 28.07.2014-02.08.2014, Lisbon] Institutional support: RVO:68081766 Keywords : mole rats * phylogeny Subject RIV: EG - Zoology http://rslisbon2014.wix.com/conference

  17. Anatomy of mole external genitalia: Setting the record straight.

    Science.gov (United States)

    Sinclair, Adriane Watkins; Glickman, Stephen E; Baskin, Laurence; Cunha, Gerald R

    2016-03-01

    Anatomy of male and female external genitalia of adult mice (Mus musculus) and broad-footed moles (Scapanus latimanus) was re-examined to provide more meaningful anatomical terminology. In the past the perineal appendage of male broad-footed moles has been called the penis, while the female perineal appendage has been given several terms (e.g. clitoris, penile clitoris, peniform clitoris and others). Histological examination demonstrates that perineal appendages of male and female broad-footed moles are the prepuce, which in both sexes are covered externally with a hair-bearing epidermis and lacks erectile bodies. The inner preputial epithelium is non-hair-bearing and defines the preputial space in both sexes. The penis of broad-footed moles lies deep within the preputial space, is an "internal organ" in the resting state and contains the penile urethra, os penis, and erectile bodies. The clitoris of broad-footed moles is defined by a U-shaped clitoral epithelial lamina. Residing within clitoral stroma encompassed by the clitoral epithelial lamina is the corpus cavernosum, blood-filled spaces and the urethra. External genitalia of male and female mice are anatomically similar to that of broad-footed moles with the exception that in female mice the clitoris contains a small os clitoridis and lacks defined erectile bodies, while male mice have an os penis and a prominent distal cartilaginous structure within the male urogenital mating protuberance (MUMP). Clitori of female broad-footed moles lack an os clitoridis but contain defined erectile bodies, while male moles have an os penis similar to the mouse but lack the distal cartilaginous structure. PMID:26694958

  18. Magnetic compass orientation in the blind mole rat Spalax ehrenbergi.

    Science.gov (United States)

    Kimchi, T; Terkel, J

    2001-02-01

    The blind mole rat Spalax ehrenbergi is a solitary, subterranean rodent that digs and inhabits a system of branching tunnels, with no above-ground exits, which it never leaves unless forced to. To survive, the mole rat must be able to orient efficiently in its tunnel system. The sensory channels available for spatial orientation in the subterranean environment are restricted in comparison with those existing above ground. This study examined the possibility that the mole rat is able to perceive and use the earth's magnetic field to orient in space. Experiments were performed using a device constructed from a pair of electromagnetic 'Helmholtz coils', which create a magnetic field whose direction and strength can be altered. In the first experiment, we tested a group of mole rats (N=33) in an eight-armed maze under the earth's natural magnetic field to determine whether they have directional preferences for the location of their sleeping nest, food chamber and toilet site. A second group of mole rats (N=30) was tested for their directional preference after the earth's magnetic field had been experimentally shifted by 180 degrees. We found that the first group exhibited a significant preference (Pbuild both their sleeping nest and their food store in the southern sector of the maze, whereas the second group shifted the location of their nests (Pbirds, magnetic compass orientation in the mole rat is independent of light stimulation. In the third experiment, we examined whether mole rats (N=24) use the earth's magnetic field as a compass cue to orient in a labyrinth. In the first stage (trials 1-13), the animals were trained to reach a goal box at the end of a complex labyrinth until all individuals had learned the task. In the second stage (trial 14), half the trained mole rats underwent another labyrinth trial under the earth's natural magnetic field, while the other half were tested under a magnetic field shifted by 180 degrees. We found a significant decrease (P<0

  19. Genetic variants of Cao Bang hantavirus in the Chinese mole shrew (Anourosorex squamipes) and Taiwanese mole shrew (Anourosorex yamashinai).

    Science.gov (United States)

    Gu, Se Hun; Arai, Satoru; Yu, Hon-Tsen; Lim, Burton K; Kang, Hae Ji; Yanagihara, Richard

    2016-06-01

    To determine the genetic diversity and geographic distribution of Cao Bang virus (CBNV) and to ascertain the existence of CBNV-related hantaviruses, natural history collections of archival tissues from Chinese mole shrews (Anourosorex squamipes) and Taiwanese mole shrews (Anourosorex yamashinai), captured in Guizho Province, People's Republic of China, and in Nantou County, Taiwan, in 2006 and 1989, respectively, were analyzed for hantavirus RNA by RT-PCR. Pair-wise alignment and comparison of the S-, M- and L-segment sequences indicated CBNV in two of five Chinese mole shrews and a previously unrecognized hantavirus, named Xinyi virus (XYIV), in seven of 15 Taiwanese mole shrews. XYIV was closely related to CBNV in Vietnam and China, as well as to Lianghe virus (LHEV), recently reported as a distinct hantavirus species in Chinese mole shrews from Yunnan Province in China. Phylogenetic analyses, using maximum-likelihood and Bayesian methods, showed that XYIV shared a common ancestry with CBNV and LHEV, in keeping with the evolutionary relationship between Anourosorex mole shrews. Until such time that tissue culture isolates of CBNV, LHEV and XYIV can be fully analyzed, XYIV and LHEV should be regarded as genetic variants, or genotypes, of CBNV. PMID:26921799

  20. Mola hidatiforme e doença trofoblástica gestacional Hydatidiform mole and gestational trophoblastic disease

    Directory of Open Access Journals (Sweden)

    Jurandyr Moreira de Andrade

    2009-02-01

    Full Text Available A mola hidatiforme é uma complicação relativamente infrequente da gravidez, mas com potencial para evolução para formas que necessitam de tratamento sistêmico e podem ser ameaçadoras da vida. Sob a denominação de mola hidatiforme há duas entidades histopatológicas e clínicas: a mola parcial e a completa. As diferenças entre estas duas formas são importantes, devido ao risco de evolução para formas persistentes, ou seja, mais alto para as completas. O diagnóstico da mola hidatiforme, seu tratamento e seguimento após o tratamento inicial sofreram alterações importantes nos últimos anos. O número de pacientes assintomáticas tem aumentado devido ao emprego de ultrassonografia no início da gravidez. Para a resolução da mola hidatiforme é necessário evitar o emprego de medicamentos que induzam contrações uterinas e usar a vácuo-aspiração. Deve ser prescrito o método contraceptivo hormonal logo após o esvaziamento da mola. O seguimento é baseado nas dosagens seriadas semanais de gonadotrofinas coriônicas. É importante que o método empregado detecte todas as formas das gonadotrofinas coriônicas (molécula intacta, hiperglicosilada, subunidade β livre e fragmento central da subunidade β.The hydatiform mole is a relatively rare pregnancy complication, but with potential to evolve to forms which need systemic treatment and can be a threat to life. There are two histopathological and clinical entities under the name of hydatiform mole: the partial and the complete mole. The differences between the two forms are important due to risk of evolution to persistent forms, which is higher for the complete moles. The diagnosis, treatment and follow-up of hydatiform mole have been under important changes in the last years. The number of asymptomatic patients has increased, due to the use of ultrasonography at the onset of pregnancy. The use of medication that induces uterine contractions must be avoided, and vacuum

  1. Ultrasonographic findings of Myoma, H-mole and Missed abortion

    International Nuclear Information System (INIS)

    Ultrasonography is very important in the diagnosis of various kinds of diseases in Obsterics and Gynecology. It has high diagnostic accuracy in the diagnosis of pelvic masses and widely used for the detection of normal orpathologic pregnancy. But still it is difficult to differentiate degenerated myoma, H-mole and missed abortion by ultrasonography. So the authors analyzed the ultrasonographic findings of 81 patients with myoma(29 cases), H-mole(23 cases), and missed abortion(29 cases) and the results are as follows; 1. Diagnostic accuracy was 8.6% in myoma, 87% in H-mole and 89% in missed abortion. 2. The most typical ultrasonographic finding of myoma was obulated mass contour with nonhomogenous internal echo. 3. The most characteristic finding of H-mole was fine vesicular pattern internal echo with globular enlargement of uterus. 4. The most frequent finding of missed abortion was deformed gestational sac with or without remained fetal echo. 5. Clinical correlation was very important for accurate diagnosis, especially when differential diagnosis was very difficult between myoma with marked cystic degeneration, missed abortion with large distorted gestational sac and H-mole with severe degeneration

  2. Epidemiological Factors and Pathomorphologic Characteristics of Hydatidiform Mole

    Directory of Open Access Journals (Sweden)

    Lejla Muminhodžić

    2013-09-01

    Full Text Available Introduction: Hydatidiform mole is a gestational trophoblastic disease characterized by a range of disorders of abnormal trophoblastic proliferation.Methods: This was a retrospective study of 70 singletone pregnancies until the 12th week of gestational age diagnosed with hydatidiform mole or spontaneously aborted physiological pregnancy. The pregnantwomen had almost similar demographic features and were divided into two groups. 35 pregnant women with a molar pregnancy were included in the study group; while 35 pregnant women with physiologicalpregnancy spontaneously aborted were included in the control group. Analyzed parameters included a pregnant woman’s age, blood type, parity and previous pregnancies (course and outcomes.Results: In the study group 11.43% of cases had hydatidiform mola during previous pregnancies as well as the advanced average gestational age of an ongoing pregnancy (9.63±1.83 in contrast to 8.25±2.03in the control group. The pregnant women with the hydatidiform mole were reported to have statistically significantly greater number of irregular villous borders (71.43%; slightly enlarged villi (54.29%; moderatedpresence of cisterns (65.71% as well as mild avascularisation of villi (57.14%.Conclusion: It was concluded that a previous molar pregnancy represents the highest risk for hydtidiforme mole and the pathomorphologic analysis of vilous changes can be a reliable parameter for establishingproper diagnosis of partial hydatidiform mole.

  3. Metadata Objects for Linking the Environmental Sciences (MOLES)

    Science.gov (United States)

    Lawrence, B.; Cox, S.; Ventouras, S.

    2009-04-01

    MOLES is an information model that provides a framework to support interdisciplinary contextual metadata describing instruments, observation platforms, activities, calibrations and other aspects of the environment associated with observations and simulations. MOLES has been designed as a bridge between discovery metadata - the conventional stuff of catalogues - and the sort of metadata which scientists traditionally store alongside data within files (and more rarely, databases) - "header files" and the like. MOLES can also be thought of as both a metadata structure in it's own right, and a framework for describing and recording the relationships between aspects of the context described in other more metadata formats (such as SensorML and the upcoming Metafor Common Information Model). MOLES was originally conceived of during the first NERC DataGrid project, in 2002, and is now at V3 in 2009. V3 differs from previous versions in many significant ways: 1) it has been designed in ISO 19103 compliant UML, and an XML schema implementation is delivered via an automated implementation of the ISO19118/19136 model driven architecture. 2) it is designed to operate in Web2.0 environment with both an atom serialisation and an OGC Web Feature Service (WFS) friendly XML serialisation. 3) it leverages the OGC observations and measurements specification, complements a range of GML application schema (in particular GeoSciML and CSML), and supports export of a subset of information in ISO 19115/19139 compliance. A software implementation exploiting MOLES V3 is under development. This will be seeded with hundreds of enties available from the MOLES V2 service currently deployed in the STFC Centre for Environmental Data Archival.

  4. A history of mole crickets (Orthoptera: Gryllotalpidae) in Puerto Rico

    OpenAIRE

    Frank, J. Howard

    2009-01-01

    Published claims in 1887-1903 that the mole cricket Neocurtilla hexadactyla (Perty) occurs in Puerto Rico all seem to be derived from a misidentification made by Agustín Stahl, a medical practitioner and collector of natural history objects, published in 1882. That species does not seem now to occur in Puerto Rico and almost certainly never did. However, the opportunity still exists for it to colonize by wind-assisted flight from islands to the southeast just as we believe did the mole cricke...

  5. The controversy about of the mole concept and related quantities

    International Nuclear Information System (INIS)

    In this paper a display is made of the controversy about of the mole concept and related quantities (amount of substance, Avogadro's number, Avogadro's constant and molar quantities). A review of the conceptual errors which appear frequently in the textbooks of Chemistry has been made. (Author)

  6. The mole, amount of substance and primary methods

    Science.gov (United States)

    Milton, Martin J. T.

    2013-04-01

    This paper is an introduction to the principles developed for the application of metrology to the field of chemistry and particularly to analytical chemistry. It starts with a discussion of the mole, the base unit of the SI that is most relevant to analytical chemistry. The mole has become the subject of particular discussion recently, since the publication of proposals to re-define it along with three other base units of the SI. This discussion has also generated interest in the origin of the term ‘amount of substance’ used as the quantity for which the mole is the unit. This paper reviews the origin of this term and explains why it is not sufficient to replace it with an alternative such as a ‘number of entities’. The paper concludes with some discussion of how the mole is realized through the use of primary methods of measurement. This paper is based on a lecture given at the International School of Physics ‘Enrico Fermi’, Course CLXXXV: Metrology and Physical Constants,held in Varenna on 17-27 July 2012. It will also be published in the proceedings of the school, edited by E Bava, M Kühne and A M Rossi (IOS Press, Amsterdam and SIF, Bologna).

  7. Variação estrutural quantitativa no lenho de Terminalia ivorensis A. Chev., Combretaceae Wood structural quantitative variation of the Terminalia ivorensis A. Chev., Combretaceae

    OpenAIRE

    Cláudia V. Urbinati; Aristéa A. Azevedo; Eldo A. Monteiro da Silva; Pedro L. B. Lisboa

    2003-01-01

    Com o objetivo de analisar a variação anatômica ao longo do caule de Terminalia ivorensis, estudaram-se amostras de madeira de três indivíduos, nos planos radial e axial. Para tal, corpos de prova foram obtidos a partir de discos de madeira, de 2 em 2cm, no sentido medula-câmbio. A metodologia usada para desenvolver o trabalho foi aquela tradicionalmente recomendada para estudos em anatomia vegetal. A descrição anatômica realizada seguiu as recomendações do IAWA Committee. No sentido radial d...

  8. Linewidth Narrowing and Intensity Enhancement of Wavelength Tunable MOLEDs

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Microcavity structure consisting of distributed Bragg reflector and metal aluminum mirror is designed. Using tris (8-hydroxyquinoline) aluminum as electron-transport layer and emissive layer, and N, N′-bis (3-methylphenyl)-N, N′-diphenylbenzidine as a hole-transport layer, microcavity organic light-emitting diodes(MOLEDs) are fabricated. Compared to the electroluminescence spectra of non-cavity OLEDs, the linewidth of the MOLEDs is compressed from 75 nm to 7 nm, and the peak intensity enhances by a factor of about 3. When the effective length of the microcavity is modified, resonance wavelength can be selectively scanned over a very wide range of wavelengths that cover almost 140 nm.

  9. STR DNA genotyping of hydatidiform moles in South China

    OpenAIRE

    Zheng, Xing-Zheng; Hui, Pei; Chang, Bin; Gao, Zhi-Bin; LI Yan; WU, BING-QUAN; Bo ZHANG

    2014-01-01

    Objective: To evacuate whether short-tandem-repeat (STR) DNA genotyping is effective for diagnostic measure to precisely classify hydatidiform moles. Methods: 150 cases were selected based on histologic features that were previously diagnosed or suspected molar pregnancy. All sections were stained with hematoxylin as a quality control method, and guided the microscopic dissection. DNA was extracted from dissected chorionic villi and paired maternal endometrial FFPE tissue sections. Then, STR ...

  10. Unilateral hydronephrosis caused by invasive mole: a case report

    OpenAIRE

    Zhang, Hai-Yan; Wu, Wei; Zhu, Jin

    2013-01-01

    Invasive mole belongs to gestational trophoblastic neoplasm, which is a highly curable group of pregnancy-related tumors. However, approximately 20% of gestational trophoblastic tumors will be resistant to or relapsed after initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. It is still unclear which regimens are the most effective and least toxic. Here, we report a case of unilateral hydronephrosis presenting 1 week after a hi...

  11. Big insights from little animals: allosteric modulation and thermal sensitivity of shrew and mole hemoglobins

    DEFF Research Database (Denmark)

    Campbell, K.L.; Weber, Roy E.

    2007-01-01

    and moles. Despite these constraints, several shrew (and mole) species flourish at elevations exceeding 4500 m (where atmospheric PO2 is < 100 mm Hg), while fossorial moles excavate subterranean burrows in severely hypoxic/hypercapnic soils. As most physiological and morphological traits are likely...

  12. Gibraltar from end of Old [mistitled] Mole. circa 1880

    OpenAIRE

    Unknown

    2003-01-01

    1206 x 221 mm. A panoramic view composed of 5 joined prints, cloth-backed. The panorama shows a view looking towards the south part of the town from the New Mole. At the right of the photograph ships and hulks are moored at the dockyard with the town beyond. Among the prominent buildings identifiable are the South Barracks behind the town, the Barrack Chapel directly in front, and the Station Hospital on the skyline at the right of the picture. The panorama follows the sea wall and the R...

  13. The change in students' understanding of the mole concept in introductory college chemistry

    Science.gov (United States)

    Smith, Shane Harvie

    This study investigated the difference between the students' understanding of the mole concept in chemistry at the beginning and at the end of the first semester of introductory chemistry courses. The study also identified the relationship between the criterion variable understanding of the mole concept in chemistry and the independent variables of cognitive level, type of introductory college chemistry class, and the number of lectures spent teaching the mole concept. In addition, this study examined (a) the students' misconceptions and (b) the aspects of the traditional teaching methods used in the introductory college chemistry courses that helped the students' understanding of the mole concept. This study was conducted using 180 volunteer students in their first semester of an introductory college chemistry course. These students were given a pretest instrument called the Mole Concepts Examination (MCE) to measure their understanding of the mole concept, the Group Assessment of Logical Thinking (GALT) to measure the students' cognitive level of logical thinking, and a posttest of the MCE to measure the students' understanding of the mole concept at the end of the semester. In addition, an interview was given to a selected group of 18 students to find out if the students remember the teaching techniques used to help them understand the mole concept and to determine some of the misconceptions that the students retained at the end of the semester. Results indicated a statistically significant relationship between students' understanding of the mole concept and their cognitive level. There was no significant relationship between students' understanding of the mole concept and the type of class, or the number of lectures spent teaching the mole concept. Qualitative results indicated that students were able to explain their answers to the posttest questions; students were able to identify some instructional techniques that helped them to understand the mole concept

  14. do parasita ao ecossistema

    OpenAIRE

    Balazeiro, Clementina Furtado

    2011-01-01

    A triquinose é uma zoonose parasitária, cujo agente causal, um nemátode, pertence ao género Trichinella. Foram já identificadas e caracterizadas várias espécies pertencentes a este género, como T. spiralis, T. nativa, T. britovi, T. nelsoni, T. murreli, T. pseudospiralis, T. papuae e T. zimbabwensis bem como alguns genótipos, T6, T8, T9, e T12. A triquinose é uma doença transmitida por carnivorismo entre os seus hospedeiros. No Homem, a principal fonte de infecção é o consumo de carne infecta...

  15. Do conhecimento ao saber

    OpenAIRE

    Almeida, Maria Cristina Pereira dos Santos

    2013-01-01

    O relatório surge como documento final do percurso iniciado aquando do ingresso no 4º Curso de Pós – Licenciatura em Enfermagem Médico-Cirúrgica da Universidade Católica do Porto, no ano letivo 2010/2011. No decurso deste trabalho pretendemos fazer uma súmula das experiências que este período de formação nos proporcionou, dando visibilidade à unidade curricular estágio, pela sua importância na aquisição de competências na área da Enfermagem Médico-Cirúrgica, na abordagem ao ...

  16. Genetic and epigenetic analysis of recurrent hydatidiform mole.

    Science.gov (United States)

    Hayward, Bruce E; De Vos, Michel; Talati, Nargese; Abdollahi, M Reza; Taylor, Graham R; Meyer, Esther; Williams, Denise; Maher, Eamonn R; Setna, Faridon; Nazir, Kausar; Hussaini, Shahnaz; Jafri, Hussain; Rashid, Yasmin; Sheridan, Eamonn; Bonthron, David T

    2009-05-01

    Familial biparental hydatidiform mole (FBHM) is a maternal-effect autosomal recessive disorder in which recurrent pregnancy failure with molar degeneration occurs. The phenotype mimics molar pregnancy due to androgenesis, despite the normal genetic makeup of the conceptus. FBHM appears to result from a failure to establish correct maternal epigenetic identity at imprinted loci during oogenesis. Several women affected with FBHM have previously been shown to have biallelic mutations in the NLRP7 gene (NALP7). Here, we present the results of epigenetic and mutational analysis on FBHM patients from 11 families, 10 of them novel. We demonstrate a methylation defect at imprinted loci in tissue from four new FBHM cases. Biallelic NLRP7 mutations, including eight previously undescribed mutations, were found in all but one family. These results indicate for the first time that maternal imprints at some loci may be correctly specified in FBHM conceptions, since differential methylation of SGCE/PEG10 was preserved in all four cases. PMID:19309689

  17. New sytematic insights about Plio-Pleistocene moles from Poland

    Directory of Open Access Journals (Sweden)

    Gabriele Sansalone

    2016-02-01

    Full Text Available The generic attribution of the Plio-Pleistocene Polish moles ?Neurotrichus polonicus and ?Neurotrichus skoczeni has been questioned several times in the past. The fossil material belonging to ?Neurotrichus polonicus and ?Neurotrichus skoczeni is re-evaluated here and a new diagnosis is provided on the basis of qualitative considerations. In addition, a Geometric Morphometric analysis of the humerus has been performed including both extant and extinct Neurotrichini and Urotrichini taxa for comparison. Our results proved the unique morphology of the Polish material suggesting a distinct taxonomic state. The morphological variations evidenced by the humeral shape analysis agree with the observed qualitative differences and support a new generic allocation. The new genus Rzebikia gen. nov. is proposed for all the material previoulsly ascribed to ?Neurotrichus polonicus and ?Neurotrichus skoczeni.

  18. Antagonismo direto e biocontrole da podridão-mole-do-tomateiro pelo uso de procariotas Direct antagonism and biocontrol of tomato soft rot using prokaryotes

    OpenAIRE

    Victor Rafael Barra; Reginaldo da Silva Romeiro; Flávio Augusto de Oliveira Garcia; Andréa Bittencourt Moura; Harllen Sandro Alves Silva; Henrique Lopes Mendonça; Bernardo de Almeida Halfeld-Vieira

    2009-01-01

    O objetivo deste trabalho foi avaliar procariotas quanto ao potencial de antagonismo direto para o biocontrole da podridão-mole-do-tomateiro (Pectobacterium carotovorum subsp. carotovorum). Avaliaram-se 45 isolados bacterianos pelo teste de antibiose contra o patógeno. Foram feitos dois ensaios em que sementes de tomate (Lycopersicon esculentum Mill.) cv. Santa Clara foram infectadas com isolados antagônicos. As mudas foram transplantadas para solos infestados com suspensões de propágulos P. ...

  19. Idade de segregação do lenho juvenil e adulto pela variação da massa específica de açoita-cavalo Estimating the age of demarcation of young and mature wood in açoita-cavalo

    Directory of Open Access Journals (Sweden)

    Matheus Lemos de Peres

    2012-09-01

    Full Text Available O presente trabalho teve como objetivo estimar a idade de segregação do lenho de Luehea divaricata Mart. (açoita-cavalo por meio da variação radial da massa específica. Para o desenvolvimento do estudo, foram coletadas dez árvores de duas regiões do Estado do Rio Grande do Sul. Foi retirado um disco por árvore, com aproximadamente 2cm de espessura a 0,10m de altura do tronco. De cada disco, retirou-se, com auxílio de uma serra-fita, uma bagueta central de 2,0cm de largura, bem orientada no sentido radial, incluindo a medula no centro, dividiu-se então a bagueta em duas amostras "A" e "B". A massa específica foi obtida da relação entre peso seco e volume úmido. O volume úmido foi determinado de acordo com a norma ASTM D 2395 - 93, 1995. A segregação dos lenhos foi encontrada por regressão linear simples dos dados de variação da massa específica no sentido medula-casca. Foi feita uma regressão linear na faixa crescente dos dados e outra na faixa decrescente. A intersecção das retas extrapoladas foi adotada como idade de segregação. Os resultados obtidos mostraram que o lenho de açoita-cavalo segrega em aproximadamente 26 anos para a região da Depressão Central e 23 anos para a região da Encosta Superior do Nordeste. Nos dados de variação de massa específica, foi feita uma análise de variância multifatorial. Constatou-se que há diferença significativa entre lenhos e entre regiões. Por outro lado, as amostras A e B de cada árvore não foram estatisticamente diferentes entre si.This study aims to estimate the age of segregation of young and mature wood of Luehea divaricata Mart., using the radial variation of specific gravity. To the development of this study were collected ten trees from two regions of the state of Rio Grande do Sul. Discs with thickness of 2cm at 0.1m of height from the base of the trunk were used. From each disk, with the aid of a band saw, a central ribbon 2.0cm wide, and oriented in the

  20. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

    OpenAIRE

    Seluanov, Andrei; Hine, Christopher; Azpurua, Jorge; Feigenson, Marina; Bozzella, Michael; Mao, Zhiyong; Catania, Kenneth C.; Gorbunova, Vera

    2009-01-01

    The naked mole-rat is the longest living rodent with a maximum lifespan exceeding 28 years. In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as tumors have never been observed in these rodents. Furthermore, we show that a combination of activated Ras and SV40 LT fails to induce robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse fibroblasts. The mechanisms responsible for the cancer resistance of naked mole-rat...

  1. Trading new neurons for status: Adult hippocampal neurogenesis in eusocial Damaraland mole-rats.

    Science.gov (United States)

    Oosthuizen, M K; Amrein, I

    2016-06-01

    Diversity in social structures, from solitary to eusocial, is a prominent feature of subterranean African mole-rat species. Damaraland mole-rats are eusocial, they live in colonies that are characterized by a reproductive division of labor and a subdivision into castes based on physiology and behavior. Damaraland mole-rats are exceptionally long lived and reproductive animals show delayed aging compared to non-reproductive animals. In the present study, we described the hippocampal architecture and the rate of hippocampal neurogenesis of wild-derived, adult Damaraland mole-rats in relation to sex, relative age and social status or caste. Overall, Damaraland mole-rats were found to have a small hippocampus and low rates of neurogenesis. We found no correlation between neurogenesis and sex or relative age. Social status or caste was the most prominent modulator of neurogenesis. An inverse relationship between neurogenesis and social status was apparent, with queens displaying the lowest neurogenesis while the worker mole-rats had the most. As there is no natural progression from one caste to another, social status within a colony was relatively stable and is reflected in the level of neurogenesis. Our results correspond to those found in the naked mole-rat, and may reflect an evolutionary and environmentally conserved trait within social mole-rat species. PMID:26979050

  2. Partial hydatidiform mole: histologic parameters in correlation with DNA genotyping.

    Science.gov (United States)

    Buza, Natalia; Hui, Pei

    2013-05-01

    Histologic diagnosis of partial hydatidiform mole (PHM) continues to be problematic, and DNA genotyping has recently become cost-effective for precise separation of PHM from its mimics. We performed a comprehensive reevaluation of histologic parameters of PHM in correlation with DNA genotyping. A total of 143 early abortion specimens were subjected to genotyping as part of the routine workup, resulting in 60 cases of PHM, 52 cases of various chromosomal trisomies, and 31 cases of nonmolar diploid gestations. All available hematoxylin and eosin slides were reviewed retrospectively by 2 gynecologic pathologists blinded to the genotyping results. Significant histologic overlaps were present among genetically confirmed PHM, hydropic abortions, and chromosomal trisomy syndromes. The following morphologic parameters emerged with diagnostic significance for PHM: villus size, presence of 2 villous populations, round or oval pseudoinclusions, at least moderate villous hydrops, cistern formation, and trophoblastic hyperplasia. The most sensitive morphologic features for PHM included villous hydrops (86% sensitivity) or the presence of at least 1 of the following 3 parameters: 2 villous populations, round or oval pseudoinclusions, and cisterns (84% sensitivity). The presence of cisterns and villous size ≥2.5 mm had the highest positive predictive value (90%) for PHM. In conclusion, no single or combined morphologic features are sufficient for definitive diagnosis of PHM. The presence of any one of the following histologic findings should prompt DNA genotyping workup to rule out PHM: round or oval pseudoincludions, cistern formation, 2 populations of villi, and a villous size of ≥2.5 mm. PMID:23518914

  3. Genome sequencing reveals insights into physiology and longevity of the naked mole rat

    DEFF Research Database (Denmark)

    Kim, Eun Bae; Fang, Xiaodong; Fushan, Alexey A;

    2011-01-01

    The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age......-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis. Although characterized by...... significant oxidative stress, the naked mole rat proteome does not show age-related susceptibility to oxidative damage or increased ubiquitination. Naked mole rats naturally reside in large colonies with a single breeding female, the 'queen', who suppresses the sexual maturity of her subordinates. They also...

  4. Acanthocephala Parasite (Profilicollis spp.) Loads in Correlation to Pacific Mole Crab (Emerita analoga) Size

    Science.gov (United States)

    Cheng, T.; Huang, S.; Galathe, M.; Jenkins, M.; Ramirez, A.; Crosby, L.; Barrera, J.; FitzHoward, S.

    2013-12-01

    Since 2002, San Francisco Bay students have been conducting marine ecosystem monitoring through a joint project with the Long-term Monitoring Program and Experiential Training for Students (LiMPETS), in conjunction with the Gulf of Farallones National Marine Sanctuary. Each year students collect population and demographic data on Pacific mole crabs (Emerita analoga), an indicator species that lives in the sandy beach habitat in temperate regions along the Pacific Ocean. Pacific mole crabs are filter feeding crustaceans that inhabit the intertidal swash zone and are known to be an intermediate host for parasitic ';spiny-headed' worms in the phylum Acanthocephala (Profilicollis spp.). Sampling takes place during their reproductive period, which occurs from spring to fall, and includes measuring total body length of the Pacific mole crabs and dissecting them to determine presence of Acanthocephalan parasites. We hypothesize that due to larger body mass, larger Pacific mole crabs will have a greater number of Acanthocephala parasites.We conducted several analyses using the LiMPETS long-term data. Specifically, we compared body length, crab gender, and parasite abundance from Pacific mole crabs sampled from four beaches located in the county and city of San Francisco. Our results indicated that larger Pacific mole crabs do not necessarily have more parasites, but are more likely to have at least one parasite, while female Pacific mole crabs carrying eggs, have more parasites than males or females without eggs. We also found that parasite loads per mole crab was highest in the spring. Further analysis will be conducted to determine factors affecting Pacific mole crab parasite loads. Studying Pacific mole crabs help evaluate the health of California's intertidal systems and how human activities, geologic changes, and climate changes all make huge impacts to the intertidal ecosystems.

  5. Jumping mechanisms and performance of pygmy mole crickets (Orthoptera, Tridactylidae).

    Science.gov (United States)

    Burrows, M; Picker, M D

    2010-07-15

    Pygmy mole crickets live in burrows at the edge of water and jump powerfully to avoid predators such as the larvae and adults of tiger beetles that inhabit the same microhabitat. Adults are 5-6 mm long and weigh 8 mg. The hind legs are dominated by enormous femora containing the jumping muscles and are 131% longer than the body. The ratio of leg lengths is: 1:2.1:4.5 (front:middle:hind, respectively). The hind tarsi are reduced and their role is supplanted by two pairs of tibial spurs that can rotate through 180 deg. During horizontal walking the hind legs are normally held off the ground. Jumps are propelled by extension of the hind tibiae about the femora at angular velocities of 68,000 deg s(-1) in 2.2 ms, as revealed by images captured at rates of 5000 s(-1). The two hind legs usually move together but can move asynchronously, and many jumps are propelled by just one hind leg. The take-off angle is steep and once airborne the body rotates backwards about its transverse axis (pitch) at rates of 100 Hz or higher. The take-off velocity, used to define the best jumps, can reach 5.4 m s(-1), propelling the insect to heights of 700 mm and distances of 1420 mm with an acceleration of 306 g. The head and pronotum are jerked rapidly as the body is accelerated. Jumping on average uses 116 microJ of energy, requires a power output of 50 mW and exerts a force of 20 mN. In jumps powered by one hind leg the figures are about 40% less. PMID:20581268

  6. Mammalian microevolution in action: adaptive edaphic genomic divergence in blind subterranean mole-rats.

    OpenAIRE

    Polyakov, Andrei; Beharav, Alex; Avivi, Aaron; Nevo, Eviatar

    2004-01-01

    Genomic diversity of anonymous regions across the genome, most probably including coding and noncoding amplified fragment length polymorphisms (AFLPs), was examined in 20 individuals of the blind mole-rat, Spalax galili, one of four allospecies of the Spalax ehrenbergi superspecies of blind subterranean mole-rats in Israel. We compared 10 individuals from two nearby populations in Upper Galilee, separated by only a few dozen to hundreds of metres and living in two sharply contrasting ecologie...

  7. Biodiesel From Canola Oil Using a 1:1 Mole Mixture of Methanol and Ethanol

    Science.gov (United States)

    Canola oil was transesterified using a 1:1 mole mixture of methanol and ethanol (M/E) with potassium hydroxide (KOH) catalyst. Effect of catalyst concentration (0.5 to 1.5% wt/wt), mole ratio of M/E to canola oil (3:1 to 20:1) and reaction temperature (25 to 75°C) on the percentage yield measured af...

  8. Management of pest mole crickets in Florida and Puerto Rico with a nematode and parasitic wasp

    International Nuclear Information System (INIS)

    Non-indigenous invasive mole crickets, Scapteriscus vicinus Scudder (Orthoptera: Gryllotalpidae) in Florida and S. didactylus (Latreille) (the 'changa') in Puerto Rico, are being managed with an entomopathogenic nematode, Steinernema scapterisci (Nguyen and Smart) (Rhabditida: Steinernematidae), and a parasitic wasp, Larra bicolor L. (Hymenoptera: Sphecidae). Pest mole cricket populations have declined by 95% in north central Florida since these specialist natural enemies were released and established in the 1980s. Commercial production of the nematode was initiated, nearly 70 billion were applied in 34 Florida counties, and their establishment, spread, and impact on mole crickets were monitored. The infected mole crickets dispersed the nematode rapidly, so that within 6 months these parasites were present in most of the insects trapped in experimental pastures. Three years later, mole cricket populations were reduced to acceptable levels and the bahiagrass had recovered. The nematode was released for the first time in Puerto Rico during 2001 and has persisted; the wasp was introduced in the late 1930s. The geographical distribution of the wasp is being expanded in Florida and Puerto Rico by planting plots of Spermacoce verticillata (L.), a wildflower indigenous to Puerto Rico and widely distributed in southern Florida. Pastures, sod farms, golf courses, landscapes, and vegetable farms in Florida and Puerto Rico are benefiting from biological control of invasive mole crickets. (author)

  9. The Mole as an Explanatory Device: How Do You Know a Mole if You See One? A Manual for Chemistry Students. Sample Teaching Materials: The Explanatory Modes Project.

    Science.gov (United States)

    Roberts, Douglas A.

    This booklet is designed to supplement the study of introductory chemistry. It deals particularly with the mole concept but also includes ideas for analyzing the kinds of statements that appear in all science textbooks and scientific writing. The material in the booklet should be studied after the completion of an introductory textbook study of…

  10. Antagonismo direto e biocontrole da podridão-mole-do-tomateiro pelo uso de procariotas Direct antagonism and biocontrol of tomato soft rot using prokaryotes

    Directory of Open Access Journals (Sweden)

    Victor Rafael Barra

    2009-03-01

    Full Text Available O objetivo deste trabalho foi avaliar procariotas quanto ao potencial de antagonismo direto para o biocontrole da podridão-mole-do-tomateiro (Pectobacterium carotovorum subsp. carotovorum. Avaliaram-se 45 isolados bacterianos pelo teste de antibiose contra o patógeno. Foram feitos dois ensaios em que sementes de tomate (Lycopersicon esculentum Mill. cv. Santa Clara foram infectadas com isolados antagônicos. As mudas foram transplantadas para solos infestados com suspensões de propágulos P. carotovorum com OD540 de 0,45 e 0,65. Os antagonistas UFV-0005, UFV-043, UFV-BF112 e UFV-0006 foram eficientes em proteger plantas de tomateiro contra a podridão-mole.This work aimed to evaluate prokaryotes to provide direct antagonism and biocontrol of tomato soft rot (Pectobacterium carotovorum subsp. carotovorum. Forty-five bacterial isolates previously selected for biological control of several tomato (Lycopersicon esculentum Mill. diseases were evaluated using an antibiosis test. 'Santa Clara' tomato seeds were inoculated with potential antagonist isolates and transplanted to a soil infested with the pathogen, in two asseys, at a propagule concentration of OD540 0.45 and 0.65. Antagonists UFV-0005, UFV-043, UFV-BF112, and UFV-0006 protected tomato plants against soft rot disease.

  11. Incidence and review of hydatidiform mole; chorioadenoma, destruens and chorio carcinoma in Mirza Kochek Khan Hospita

    Directory of Open Access Journals (Sweden)

    Ghaffari V

    1995-04-01

    Full Text Available Initial management, incidence and review of hydatidiform mole, chorioadenoma and destruens and chorio carcinoma in Mirza Kochek khan hospital department of ob.gyn and gynecology oncology of women's hospital Tehran-Iran school of medicin from September 1985 to March 1990, 209 patients received primary management for hydatidiform mole at oncology department of Mirza Kochek Khan hospital medical school of Tehran Iran. All of these women HAD complete record available for analysis, of these, 167 women bydatidiform mole, 12 patients chorioadenoma-destruens 30 patients chorio carcinoma a survey was made of factors likely to provide an important clinical perspective patient aye and the status of pregnancy were noted. 41 patient only sharp curettage and 55 patients suction curettage to remove the hydatidiform mole. 97 patient require chemo terapy, suction curettage of the uterus is clearly the best means of management in the most cases their eyperince documents that hydatidiform mole is an high risk pregnancy that requires prompt and in tensive management.

  12. MEMS AO for Planet Finding

    Science.gov (United States)

    Rao, Shanti; Wallace, J. Kent; Shao, Mike; Schmidtlin, Edouard; Levine, B. Martin; Samuele, Rocco; Lane, Benjamin; Chakrabarti, Supriya; Cook, Timothy; Hicks, Brian; Jung, Paul

    2008-01-01

    This slide presentation reviews a method for planet finding using microelectromechanical systems (MEMS) Adaptive Optics (AO). The use of a deformable mirror (DM) is described as a part of the instrument that was designed with a nulling interferometer. The strategy that is used is described in detail.

  13. A Mole for Warm Magnetic and Optical Measurements of LHC Dipoles

    CERN Document Server

    Bottura, L; Deferne, G; Glöckner, C; Jansen, H; Köster, A; Legrand, P; Rijllart, A; Sievers, P

    2000-01-01

    A new rotating coil probe (a mole) has been developed for the simultaneous measurement of the magnetic field and magnetic axis of warm superconducting LHC dipoles and associated corrector windings. The mole houses a radial rotating coil and travels inside the magnet aperture by means of an externally driven two-way traction belt. The coil is rotated by an on-board piezo motor, being tested in view of future devices for cold measurements as the only type of motor compatible with strong magnetic fields. A virtual light spot is generated in the coil center by a LED source. The position of this light spot is measured from the outside by a system including a telescope, a CCD camera and a DSP. Jigs on reference granite tables are used to transfer the optical measurements to the magnet fiducials. We describe here the main characteristics and performance of the mole

  14. Mechanical performance of rat, mouse and mole spring traps, and possible implications for welfare performance.

    Directory of Open Access Journals (Sweden)

    Sandra E Baker

    Full Text Available Lethal spring traps are widely used for killing small mammals in the UK. Many require government approval, based primarily on humaneness. However, mole traps and break-back traps for rats and mice are exempt; those available vary widely in price and apparent quality. The EU is considering implementing a Trapping Directive that would alter UK legislation, and a recent report advised the EU that trapping legislation should cover all trapped species and encourage improvement of traps. Mechanical trap performance is often used as an indicator of welfare impact. We examined the mechanical evidence for scope to improve the welfare standards of rat, mouse and mole spring traps. We measured mechanical performance among a range of rat, mouse and mole traps. Impact momentum values varied 6-8 fold, and clamping force values 4-5.5 fold, among traps for killing each species. There was considerable overlap in the performance of rat and mouse traps. Trap-opening angle and spring type were related to impact momentum and clamping force in traps for both species. There was no relationship between price and mechanical performance in traps for any species, except talpa mole traps. We are unable to judge the direct welfare impact of the traps tested, but rather the potential welfare threat associated with their exemption from approval. The wide variation in mechanical performance in traps for each species, overlap in performance between rat and mouse traps and increasing availability of weaker plastic rodent traps indicate considerable scope for improving the humaneness of spring traps for rats, mice and moles. We conclude that all such traps should be subject to the UK approval process. New welfare categories might improve trap standards further. Our results could also help improve rodent trap design and assist consumers in selecting more powerful traps. Many thousands of rats, mice and moles might benefit.

  15. Extended longevity of reproductives appears to be common in Fukomys mole-rats (Rodentia, Bathyergidae.

    Directory of Open Access Journals (Sweden)

    Philip Dammann

    Full Text Available African mole-rats (Bathyergidae, Rodentia contain several social, cooperatively breeding species with low extrinsic mortality and unusually high longevity. All social bathyergids live in multigenerational families where reproduction is skewed towards a few breeding individuals. Most of their offspring remain as reproductively inactive "helpers" in their natal families, often for several years. This "reproductive subdivision" of mole-rat societies might be of interest for ageing research, as in at least one social bathyergid (Ansell's mole-rats Fukomys anselli, breeders have been shown to age significantly slower than non-breeders. These animals thus provide excellent conditions for studying the epigenetics of senescence by comparing divergent longevities within the same genotypes without the inescapable short-comings of inter-species comparisons. It has been claimed that many if not all social mole-rat species may have evolved similar ageing patterns, too. However, this remains unclear on account of the scarcity of reliable datasets on the subject. We therefore analyzed a 20-year breeding record of Giant mole-rats Fukomys mechowii, another social bathyergid species. We found that breeders indeed lived significantly longer than helpers (ca. 1.5-2.2fold depending on the sex, irrespective of social rank or other potentially confounding factors. Considering the phylogenetic positions of F. mechowii and F. anselli and unpublished data on a third Fukomys-species (F. damarensis showing essentially the same pattern, it seems probable that the reversal of the classic trade-off between somatic maintenance and sexual reproduction is characteristic of the whole genus and hence of the vast majority of social mole-rats.

  16. Mole ghrelin: cDNA cloning, gene expression, and diverse molecular forms in Mogera imaizumii.

    Science.gov (United States)

    Satou, Motoyasu; Kaiya, Hiroyuki; Nishi, Yoshihiro; Shinohara, Akio; Kawada, Shin-Ichiro; Miyazato, Mikiya; Kangawa, Kenji; Sugimoto, Hiroyuki

    2016-06-01

    Here, we describe cDNA cloning and purification of the ghrelin gene sequences and ghrelin peptides from the Japanese true mole, Mogera imaizumii. The gene spans >2.9kbp, has four exons and three introns, and shares structural similarity with those of terrestrial animals. Mature mole ghrelin peptide was predicted to be 28 amino acids long (GSSFLSPEHQKVQQRKESKKPPSKPQPR) and processed from a prepropeptide of 116 amino acids. To further elucidate molecular characteristics, we purified ghrelin peptides from mole stomach. By mass spectrometry, we found that the mole ghrelin peptides had higher ratios of the odd-number fatty acids (C9 and C11 as much as C8) attached to the third serine residue than other vertebrate ghrelin. Truncated forms of ghrelins such as [1-27], [1-19], [1-16] and [1-15], and that lacked the 14th glutamine residue (des-Gln14 ghrelin) were produced in the stomach. Marked expression of ghrelin mRNA in lung was observed as in stomach and brain. Phylogenetic analysis indicated that the branch of M. imaizumii has slightly higher dN/dS ratios (the nucleotide substitution rates at non-synonymous and synonymous sites) than did other eulipotyphlans. Peptide length was positively correlated with human ghrelin receptor activation, whereas the length of fatty-acyl chains showed no obvious functional correlation. The basal higher luciferase activities of the 5'-proximal promoter region of mole ghrelin were detected in ghrelin-negative C2C12 cells and hypoxic culture conditions impaired transcriptional activity. These results indicated that moles have acquired diverse species of ghrelin probably through distinctive fatty acid metabolism because of their food preferences. The results provide a gateway to understanding ghrelin metabolism in fossorial animals. PMID:27102942

  17. Twin pregnancy with both complete hydatiform mole and coexistent alive fetus:case report

    Institute of Scientific and Technical Information of China (English)

    Achour Radhouane; Ben Aissa Imen; NEJI Khaled

    2015-01-01

    Twin pregnancy consisting of a complete hydatidiform mole coexisting with a live fetus is a rare condition with an incidence of 1 in 22 000 to 1 in 1 00 000 pregnancies. Clinical information is limited and management is difficult due to the risk of pregnancy complications such as fetal death, vaginal bleeding, preeclampsia, hyperthyroidism, and the risk of persistent gestational trophoblastic disease. Thus, the report described about the change of size and implantation site of the molar mass coexisting with a live fetus is rare especially about sonographic findings such as echo patterns. Recently we experienced a case of complete hydatidiform mole with a healthy infant delivered at term.

  18. Structural, magnetic and microwave properties of barium hexaferrite thick films with different Fe/Ba mole ratio

    International Nuclear Information System (INIS)

    Barium hexaferrite (BaFe12O19) thick films (∼60 µm) with different BaO·xFe2O3 mole ratio (x=5.0–6.0) were prepared by screen printing method. X-ray diffraction analysis confirmed the formation of single phase BaFe12O19 (BaM). Preferential site occupation of Fe3+ ion at five different crystallographic sites, with varied mole ratio was measured by Mössbauer spectroscopy. Vacancy fraction found to be higher at 4f1, 4f2 and 2b sites for mole ratio 5.5 and 5.0 respectively. Magnetic measurement shows that the magnetization (M) and magnetocrystalline anisotropy field (Ha) depends upon mole ratio. M and Ha are found to be maximum for mole ratio 5.5, while the coercivity (Hc) remains constant. Reflection losses (RL) in the frequency range of 12–18 GHz were also studied. Present investigation demonstrates the effect of mole ratio on structural, magnetic and microwave absorption properties of BaM thick films for microwave device applications. - Highlights: • Single phase BaM thick films with different Fe/Ba mole ratio are prepared. • Site preference of Fe ion is estimated by Mössbauer spectroscopy. • Magnetization and magnetocrystalline ansisotropy is found maximum for 5.5 mole ratio. • Absorption frequency found to vary with the mole ratio

  19. Cometas: Das Lendas aos Fatos

    Science.gov (United States)

    Voelzke, M. R.

    O descobrimento de cometas, devido ao seu aparecimento espetacular, tem registro nas mais antigas culturas humanas. A primeira referência situa-se no ano de 1095 antes de Cristo [a.C.; HO; HO, 1962]. A quantidade de registros de descobrimentos cometários, principalmente provenientes do território chinês em particular e do oriente em geral, aumentou gradualmente a partir do quarto século depois de Cristo (d.C.). É de origem chinesa a primeira referência ao cometa P/Halley no ano de 240 a.C. [VOELZKE, 1993]. Com o desenvolvimento da astronomia relativamente às técnicas observacionais os descobrimentos bem como as observações cometárias aumentaram sensivelmente a partir do século XVII, sendo que a partir do século XIX um novo incremento ocorreu devido ao emprego da fotografia e a resultante melhora de sensibilidade na observação.

  20. Reading about the Power of Music: "Mole Music" and "Children of the Stone"

    Science.gov (United States)

    Cardany, Audrey Berger

    2016-01-01

    In this article, I review two books that address the power of music for the individual and group. Both books address the benefits of making, learning, and listening to music during times of conflict. The first brief review is David McPhail's picture book "Mole Music." The second is "Children of the Stone: The Power of Music in a…

  1. The Atomic Mass Unit, the Avogadro Constant, and the Mole: A Way to Understanding

    Science.gov (United States)

    Baranski, Andrzej

    2012-01-01

    Numerous articles have been published that address problems encountered in teaching basic concepts of chemistry such as the atomic mass unit, Avogadro's number, and the mole. The origin of these problems is found in the concept definitions. If these definitions are adjusted for teaching purposes, understanding could be improved. In the present…

  2. Background Mole Fractions of Hydrocarbons in North America Determined from NOAA Global Reference Network Data

    Science.gov (United States)

    Mielke-Maday, I.

    2015-12-01

    The National Oceanic and Atmospheric Administration (NOAA) Global Monitoring Division (GMD) maintains a global reference network for over 50 trace gas species and analyzes discrete air samples collected by this network throughout the world at the Earth System Research Laboratory in Boulder, Colorado. In particular, flask samples are analyzed for a number of hydrocarbons with policy and health relevance such as ozone precursors, greenhouse gases, and hazardous air pollutants. Because this global network's sites are remote and therefore minimally influenced by local anthropogenic emissions, these data yield information about background ambient mole fractions and can provide a context for observations collected in intensive field campaigns, such as the Front Range Air Pollution and Photochemistry Experiment (FRAPPE), the Southeast Nexus (SENEX) study, and the DISCOVER-AQ deployments. Information about background mole fractions during field campaigns is critical for calculating hydrocarbon enhancements in the region of study and for assessing the extent to which a particular region's local emissions sources contribute to these enhancements. Understanding the geographic variability of the background and its contribution to regional ambient mole fractions is also crucial for the development of realistic regulations. We present background hydrocarbon mole fractions and their ratios in North America using data from air samples collected in the planetary boundary layer at tall towers and aboard aircraft from 2008 to 2014. We discuss the spatial and seasonal variability in these data. We present trends over the time period of measurements and propose possible explanations for these trends.

  3. Trauma and humanitarian translation in Liberia: the tale of open mole.

    Science.gov (United States)

    Abramowitz, Sharon Alane

    2010-06-01

    The focus of this paper is the intercultural process through which Open Mole and trauma-related mental illnesses are brought together in the postconflict mental health encounter. In this paper, I explore the historical dimension of this process by reviewing the history of Open Mole, and the ways in which it has been interpreted, acted on, and objectified by external observers over the last half-century. Moving into Liberia's recent war and postconflict period, I examine the process by which Open Mole is transformed from a culture-bound disorder into a local idiom of trauma, and how it has become a gateway diagnosis of PTSD-related mental illnesses, and consider how it is produced as an objectified experience of psychiatric disorder in clinical humanitarian contexts. By studying how Open Mole is transformed in the humanitarian encounter, I address the structure and teleology of the humanitarian encounter and challenge some of the foundational assumptions about cultural sensitivity and community-based mental health care in postconflict settings that are prevalent in scholarship and practice today. PMID:20401629

  4. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

    NARCIS (Netherlands)

    S.L. Macrae (Sheila L.); Q. Zhang (Quanwei); C. Lemetre (Christophe); I. Seim (Inge); R.B. Calder (Robert B.); J.H.J. Hoeijmakers (Jan); Y. Suh (Yousin); V.N. Gladyshev (Vadim N.); A. Seluanov (Andrei); V. Gorbunova (Vera); J. Vijg (Jan); Z.D. Zhang (Zhengdong D.)

    2015-01-01

    textabstractGenome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM g

  5. The sense of touch in the star-nosed mole: from mechanoreceptors to the brain.

    Science.gov (United States)

    Catania, Kenneth C

    2011-11-12

    Star-nosed moles are somatosensory specialists that explore their environment with 22 appendages that ring their nostrils. The appendages are covered with sensory domes called Eimer's organs. Each organ is associated with a Merkel cell-neurite complex, a lamellated corpuscle, and a series of 5-10 free nerve endings that form a circle of terminal swellings. Anatomy and electrophysiological recordings suggest that Eimer's organs detect small shapes and textures. There are parallels between the organization of the mole's somatosensory system and visual systems of other mammals. The centre of the star is a tactile fovea used for detailed exploration of objects and prey items. The tactile fovea is over-represented in the neocortex, and this is evident in the modular, anatomically visible representation of the star. Multiple maps of the star are visible in flattened cortical preparations processed for cytochrome oxidase or NADPH-diaphorase. Star-nosed moles are the fastest known foragers among mammals, able to identify and consume a small prey item in 120 ms. Together these behavioural and nervous system specializations have made star-nosed moles an intriguing model system for examining general and specialized aspects of mammalian touch. PMID:21969683

  6. Hydatidiform mole and fetus with normal karyotype: support of a separate entity

    DEFF Research Database (Denmark)

    Vejerslev, L O; Sunde, L; Hansen, B F;

    1991-01-01

    Repetitive hydatidiform mole was observed in four pregnancies. The pregnancies presented with heavy bleeding and vomiting, but the post-evacuation courses were uncomplicated, with rapid regression of serum hCG levels. Cytogenetic investigations, analyses of restriction fragment length polymorphis...

  7. Efeito da mobilização de tecidos moles nas concentrações de ácido láctico, após exercício intensivo

    OpenAIRE

    Brito, Juliana Alves; Leite, Pedro Harry; Paquete, Manuel

    2011-01-01

    Objectivo do estudo: verificar o efeito da mobilização dos tecidos moles nas concentrações de ácido láctico, após exercício intensivo. Critérios de exclusão: lesão ou cirurgia ao nível do membro inferior dominante; presença de qualquer doença neurológica, dermatológica, sistémica, cardiovascular ou vascular periférica; dor ao nível da musculatura em avaliação; não realizar qualquer tipo de tratamentos de Fisioterapia.

  8. Unraveling the message: insights into comparative genomics of the naked mole-rat.

    Science.gov (United States)

    Lewis, Kaitlyn N; Soifer, Ilya; Melamud, Eugene; Roy, Margaret; McIsaac, R Scott; Hibbs, Matthew; Buffenstein, Rochelle

    2016-08-01

    Animals have evolved to survive, and even thrive, in different environments. Genetic adaptations may have indirectly created phenotypes that also resulted in a longer lifespan. One example of this phenomenon is the preternaturally long-lived naked mole-rat. This strictly subterranean rodent tolerates hypoxia, hypercapnia, and soil-based toxins. Naked mole-rats also exhibit pronounced resistance to cancer and an attenuated decline of many physiological characteristics that often decline as mammals age. Elucidating mechanisms that give rise to their unique phenotypes will lead to better understanding of subterranean ecophysiology and biology of aging. Comparative genomics could be a useful tool in this regard. Since the publication of a naked mole-rat genome assembly in 2011, analyses of genomic and transcriptomic data have enabled a clearer understanding of mole-rat evolutionary history and suggested molecular pathways (e.g., NRF2-signaling activation and DNA damage repair mechanisms) that may explain the extraordinarily longevity and unique health traits of this species. However, careful scrutiny and re-analysis suggest that some identified features result from incorrect or imprecise annotation and assembly of the naked mole-rat genome: in addition, some of these conclusions (e.g., genes involved in cancer resistance and hairlessness) are rejected when the analysis includes additional, more closely related species. We describe how the combination of better study design, improved genomic sequencing techniques, and new bioinformatic and data analytical tools will improve comparative genomics and ultimately bridge the gap between traditional model and nonmodel organisms. PMID:27364349

  9. Massagem ao bebé

    OpenAIRE

    Figueiredo, Bárbara

    2007-01-01

    Apresenta-se uma revisão da investigação desenvolvida no âmbito da massagem e da estimulação táctil-cinestésica ao bebé. Descrevem-se os estudos empíricos conduzidos no sentido de avaliar os efeitos no desenvolvimento, no bem-estar e em problemas específicos do bebé de termo e prematuro. Conclui-se a respeito do impacto positivo da massagem sobre a criança, os pais e na interacção entre ambos; nomeadamente porque beneficia dois objectivos primordiais dos cuidados de ...

  10. Avaliação de ciclo de vida da produção e utilização de hidrogénio com base em biomassa lenho celulósica para Portugal

    OpenAIRE

    Coelho, Ana Filipa Duarte de Sousa

    2008-01-01

    Esta dissertação resulta do trabalho realizado durante o segundo semestre do ano lectivo 2007/2008, no âmbito da Dissertação Final do Mestrado Integrado em Engenharia do Ambiente, no ramo da Tecnologia e Gestão do Ambiente. O crescente aumento do preço do barril do petróleo e os importantes impactes ambientais associados ao uso e produção dos combustíveis fósseis tem contribuído para o potencial uso do hidrogénio como substituto dos combustíveis fósseis. Contudo, a maior p...

  11. Mole (Nevus)

    Science.gov (United States)

    ... melanoma). Remember the ABCDEs of melanoma lesions: A - Asymmetry: One half of the lesion does not mirror ... McGraw-Hill, 2003. Last Updated: 23 Jul 2010 Information for other ages: Child Teen Table of Contents: ...

  12. GESTATIONAL TROPHOBLASTIC DISEASE: A PROSPECTIVE STUDY OF 82 CASES AND UTILITY OF P57 IMMUNOHISTOCHEMISTRY IN DIFFERENTIATING COMPLETE AND PARTIAL MOLE

    Directory of Open Access Journals (Sweden)

    Surya Babu

    2014-12-01

    Full Text Available BACKGROUND AND PURPOSE: Gestational trophoblastic disease (GTD is a common spectrum of abnormal placental villous trophoblastic proliferation that occurs in women of reproductive age group. The present study is undertaken to discuss about the epidemiology, clinical presentation and pathology diagnosis of each of the trophoblastic disease variants. MATERIALS AND METHODS: The present study included 82 cases of GTD over a period of 3 years. The H&E sections of FFPE tissue were studied. Periodic acid Schiff (PAS stain was done as an adjuvant in 5 cases of early complete mole. IHC with p57kip2 was done in 6 cases of complete mole and 6 cases of partial mole. RESULTS: Hydatidiform mole (93.9% was the most common variant of GTD with peak incidence in 21-30 years age group and more common in primigravida. There were one case of invasive mole, 2 cases of choriocarcinoma and 2 cases of persistent trophoblastic disease. Most patients of GTD were of blood group O followed by group A. Early complete mole, complete mole and partial mole were differentiated by examining H&E sections. Myxoid stroma of early complete mole showed PAS positivity. p57 was negative in all the 6 cases of complete mole. Five cases of partial mole showed positivity, but one case was negative; on review, it was diagnosed as complete mole.CONCLUSION: The study shows the high incidence of molar pregnancies in Indian women and discusses the importance and utility of IHC in hydatidiform mole pathology.

  13. Seasonal changes in burrow geometry of the common mole rat (Rodentia: Bathyergidae)

    Science.gov (United States)

    Thomas, H. G.; Scantlebury, M.; Swanepoel, D.; Bateman, P. W.; Bennett, N. C.

    2013-11-01

    Sociality in mole rats has been suggested to have evolved as a response to the widely dispersed food resources and the limited burrowing opportunities that result from sporadic rainfall events. In the most arid regions, individual foraging efficiency is reduced, and energetic constraints increase. In this study, we investigate seasonal differences in burrow architecture of the social Cryptomys hottentotus hottentotus in a mesic region. We describe burrow geometry in response to seasonal weather conditions for two seasons (wet and dry). Interactions occurred between seasons and colony size for the size of the burrow systems, but not the shape of the burrow systems. The fractal dimension values of the burrow systems did not differ between seasons. Thus, the burrow complexity was dependent upon the number of mole rats present in the social group.

  14. Effects of ultraviolet radiation on mole rats kidney: A histopathologic and ultrastructural study

    Directory of Open Access Journals (Sweden)

    Hüseyin Türker

    2014-04-01

    Full Text Available The purpose of this study was to realize the ultrastructural effects of ultraviolet radiation on the kidney tissue cells of mole rats (Spalax leucodon. The mole rats of 180–200 g body weight were divided into the control and radiation-trial groups. The control group was not given any radiation. The other groups were irradiated with artificially produced UVC radiation for 14, 28 and 60 days. The kidney tissue samples were prepared at the end of experiments and analyzed by the light and electron microscope. Several effects were observed in the kidney tissues cells analyzed in accordance with the dose magnitude of radiation. These results clearly show the detrimental effects of UVC radiation on kidney tissue cells in exposure periods dependent on radiation dose and exposure time.

  15. Twin pregnancy with complete hydatidiform mole and coexisting live fetus complicated with HELLP syndrome

    Directory of Open Access Journals (Sweden)

    Deepti Sharma

    2013-02-01

    Full Text Available Hydatidiform mole with a coexisting live twin is an extremely rare event. It poses a great challenge for the obstetrician to decide for or against continuation of such a pregnancy, especially if the conception is after infertility treatment. Continuation carries risk of medical complications and persistent trophoblastic disease. We report a case of 22 year old primigravida, with complete hydatidiform mole coexisting with a live fetus. Patient had conceived in her fourth cycle of ovulation induction and wanted to continue pregnancy. She developed severe preeclampsia and HELLP syndrome. In this case report we highlight the importance of intense antenatal monitoring and the possibility of sudden deterioration of maternal condition forcing immediate termination. [Int J Reprod Contracept Obstet Gynecol 2013; 2(1.000: 92-94

  16. Analysis of internal doses to Mole voles inhabiting the East-Ural radioactive trace

    Energy Technology Data Exchange (ETDEWEB)

    Malinovsky, G.; Yarmoshenko, I. [Institute of Industrial Ecology UB RAS (Russian Federation); Chibiryak, M.; Vasil' ev, A. [Institute of Plant and Animal Ecology UB RAS (Russian Federation)

    2014-07-01

    Substantial task of development of approaches to radiation protection of non-human biota is investigation of relationships of exposure to dose, and dose to effects. Small mammals inhabiting territory of the East-Ural Radioactive Trace (EURT) are affected to ionizing radiation for many generations after accident at Mayak plutonium production in 1957. According to results of numerous studies a number of effects of exposure are observed. It is remarkable that the revealed effects are both negative and adaptive. In particular, the analysis of the variability of morphological structures of the axial skull and lower jaw in the population of northern mole vole (Ellobius talpinus Pall.), the burrowing rodent inhabiting the EURT, is of great interest. At the same time there is no reliable assessment of the radiation doses to these animals. Earlier we developed the approach to assess internal doses to mouse-like rodents (mice and voles) caused by incorporated {sup 90}Sr, which is the main dose contributing radionuclide at the EURT. Dose assessments are based on the results of beta-radiometry of intact bone. Routine methods for measuring the activity concentration of {sup 90}Sr in skeleton require ashing of samples, however in morphometric studies the destruction of material should be avoided: the skulls of mole voles are stored in the environmental samples depository of IPAE. Coefficients linking results of beta-radiometry of intact bone and activity concentration of {sup 90}Sr in skull of mouse was obtained basing on comparison of results of beta-radiometry of intact bone and bone ash. Obtained coefficients cannot be directly applied for calculating activity concentration of {sup 90}Sr in mole vole skulls because they are significantly larger. Therefore the additional study is required to assess proper coefficient of conversion from beta-radiometry to activity concentration of {sup 90}Sr. Developed dose assessment procedure includes application of the published values of

  17. Aerosol Observing System (AOS) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Jefferson, A

    2011-01-17

    The Aerosol Observing System (AOS) is a suite of in situ surface measurements of aerosol optical and cloud-forming properties. The instruments measure aerosol properties that influence the earth’s radiative balance. The primary optical measurements are those of the aerosol scattering and absorption coefficients as a function of particle size and radiation wavelength and cloud condensation nuclei (CCN) measurements as a function of percent supersaturation. Additional measurements include those of the particle number concentration and scattering hygroscopic growth. Aerosol optical measurements are useful for calculating parameters used in radiative forcing calculations such as the aerosol single-scattering albedo, asymmetry parameter, mass scattering efficiency, and hygroscopic growth. CCN measurements are important in cloud microphysical models to predict droplet formation.

  18. Mechanical Performance of Rat, Mouse and Mole Spring Traps, and Possible Implications for Welfare Performance

    OpenAIRE

    Baker, Sandra E.; Ellwood, Stephen A.; Tagarielli, Vito L.; Macdonald, David W.

    2012-01-01

    Lethal spring traps are widely used for killing small mammals in the UK. Many require government approval, based primarily on humaneness. However, mole traps and break-back traps for rats and mice are exempt; those available vary widely in price and apparent quality. The EU is considering implementing a Trapping Directive that would alter UK legislation, and a recent report advised the EU that trapping legislation should cover all trapped species and encourage improvement of traps. Mechanical...

  19. Genome sequencing reveals insights into physiology and longevity of the naked mole rat

    OpenAIRE

    Kim, Eun Bae; Fang, Xiaodong; Fushan, Alexey A.; Huang, Zhiyong; Lobanov, Alexei V.; Han, Lijuan; Marino, Stefano M.; Sun, Xiaoqing; Turanov, Anton A; Yang, Pengcheng; Yim, Sun Hee; Zhao, Xiang; Kasaikina, Marina V.; Stoletzki, Nina; Peng, Chunfang

    2011-01-01

    The naked mole rat (NMR, Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal 1 . Although the size of a mouse, its maximum lifespan exceeds 30 years and makes this animal the longest living rodent. NMRs show negligible senescence, no age-related increase in mortality, and high fecundity until death 2 . In addition to delayed aging, NMRs are resistant to both spontaneous cancer and experimentally induced tumorigenesis 3,4 . NMRs pose a challenge to the...

  20. Digital dissection of the masticatory muscles of the naked mole-rat, Heterocephalus glaber (Mammalia, Rodentia

    Directory of Open Access Journals (Sweden)

    Philip G. Cox

    2014-06-01

    Full Text Available The naked mole-rat, Heterocephalus glaber, of the family Bathyergidae is a subterranean rodent that feeds on underground roots and tubers and digs extensive tunnel systems with its incisors. It is a highly unusual mammal with regard to its social structure, longevity, pain insensitivity and cancer resistance, all of which have made it the subject of a great deal of research in recent years. Yet, much of the basic anatomy of this species remains undocumented. In this paper, we describe the morphology of the jaw-closing musculature of the naked mole-rat, as revealed by contrast-enhanced micro-computed tomography. This technique uses an iodine stain to enable the imaging of soft tissues with microCT. The iodine-enhanced scans were used to create 3D reconstructions of the naked mole-rat masticatory muscles from which muscle masses were calculated. The jaw-closing musculature of Heterocephalus glaber is relatively very large compared to other rodents and is dominated by the superficial masseter, the deep masseter and the temporalis. The temporalis in particular is large for a rodent, covering the entirety of the braincase and much of the rear part of the orbit. The morphology of the masseter complex described here differs from two other published descriptions of bathyergid masticatory muscles, but is more similar to the arrangement seen in other rodent families. The zygomaticomandibularis (ZM muscle does not protrude through the infraorbital foramen on to the rostrum and thus the naked mole-rat should be considered protrogomorphous rather than hystricomorphous, and the morphology is consistent with secondarily lost hystricomorphy as has been previously suggested for Bathyergidae. Overall, the morphology of the masticatory musculature indicates a species with a high bite force and a wide gape–both important adaptations for a life dominated by digging with the incisors.

  1. On the Mole-Rat (Cryptomys Hottentotus Damarensis (Rodentia in the Kalahari Gemsbok National Park

    Directory of Open Access Journals (Sweden)

    G de Graaff

    1972-01-01

    Full Text Available Aspects of the ecology and distribution of the Damara mole-rat (Cryptomys hottentotus damarensis are discussed relative to its life in the arid Kalahari Gemsbok National Park. The value of coat colour as a taxonomic criterion for the subspecies is discussed. Notes are also presented on reproduction, aspects of behaviour such as: habitat, nests, orientation, activity, locomotion, voice, food, feeding and social life, symbiosis, commensalism, parasites and predators.

  2. The reproductive biology of the Mashona mole - rat (\\kur{Fukomys darlingi}) from southern Malawi.

    OpenAIRE

    JERKOVIČOVÁ, Diana

    2010-01-01

    The population of the social Mashona mole - rat (Fukomys darlingi) from southern Malawi differs from the population from Zimbabwe in many aspects of its biology. In this study I have found remarkable differences also in the reproductive biology of these two populations. The most signifiant distinctions are double lenght of gestation and litters with more and larger pups in Malawian population. The analysis of reproductive and ecological parameters in bathyergids did not showed obvious differe...

  3. The sense of touch in the star-nosed mole: from mechanoreceptors to the brain

    OpenAIRE

    Kenneth C. Catania

    2011-01-01

    Star-nosed moles are somatosensory specialists that explore their environment with 22 appendages that ring their nostrils. The appendages are covered with sensory domes called Eimer's organs. Each organ is associated with a Merkel cell–neurite complex, a lamellated corpuscle, and a series of 5–10 free nerve endings that form a circle of terminal swellings. Anatomy and electrophysiological recordings suggest that Eimer's organs detect small shapes and textures. There are parallels between the ...

  4. Family Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis.

    Science.gov (United States)

    Davies, Kalina T J; Bennett, Nigel C; Tsagkogeorga, Georgia; Rossiter, Stephen J; Faulkes, Christopher G

    2015-12-01

    During their evolutionary radiation, mammals have colonized diverse habitats. Arguably the subterranean niche is the most inhospitable of these, characterized by reduced oxygen, elevated carbon dioxide, absence of light, scarcity of food, and a substrate that is energetically costly to burrow through. Of all lineages to have transitioned to a subterranean niche, African mole-rats are one of the most successful. Much of their ecological success can be attributed to a diet of plant storage organs, which has allowed them to colonize climatically varied habitats across sub-Saharan Africa, and has probably contributed to the evolution of their diverse social systems. Yet despite their many remarkable phenotypic specializations, little is known about molecular adaptations underlying these traits. To address this, we sequenced the transcriptomes of seven mole-rat taxa, including three solitary species, and combined new sequences with existing genomic data sets. Alignments of more than 13,000 protein-coding genes encompassed, for the first time, all six genera and the full spectrum of ecological and social variation in the clade. We detected positive selection within the mole-rat clade and along ancestral branches in approximately 700 genes including loci associated with tumorigenesis, aging, morphological development, and sociality. By combining these results with gene ontology annotation and protein-protein networks, we identified several clusters of functionally related genes. This family wide analysis of molecular evolution in mole-rats has identified a suite of positively selected genes, deepening our understanding of the extreme phenotypic traits exhibited by this group. PMID:26318402

  5. Cutaneous and periodontal inputs to the cerebellum of the naked mole-rat (Heterocephalus glaber

    Directory of Open Access Journals (Sweden)

    Diana K Sarko

    2013-11-01

    Full Text Available The naked mole-rat (Heterocephalus glaber is a small fossorial rodent with specialized dentition that is reflected by the large cortical area dedicated to representation of the prominent incisors. Due to naked mole-rats’ behavioral reliance on the incisors for digging and for manipulating objects, as well as their ability to move the lower incisors independently, we hypothesized that expanded somatosensory representations of the incisors would be present within the cerebellum in order to accommodate a greater degree of proprioceptive, cutaneous, and periodontal input. Multiunit electrophysiological recordings targeting the ansiform lobule were used to investigate tactile inputs from receptive fields on the entire body with a focus on the incisors. Similar to other rodents, a fractured somatotopy appeared to be present with discrete representations of the same receptive fields repeated within each folium of the cerebellum. These findings confirm the presence of somatosensory inputs to a large area of the naked mole-rat cerebellum with particularly extensive representations of the lower incisors and mystacial vibrissae. We speculate that these extensive inputs facilitate processing of tactile cues as part of a sensorimotor integration network that optimizes how sensory stimuli are acquired through active exploration and in turn adjusts motor outputs (such as independent movement of the lower incisors. These results highlight the diverse sensory specializations and corresponding brain organizational schemes that have evolved in different mammals to facilitate exploration of and interaction with their environment.

  6. Egg donor pregnancy: a potential pitfall in DNA genotyping diagnosis of hydatidiform moles.

    Science.gov (United States)

    Buza, Natalia; Hui, Pei

    2014-09-01

    A 34-yr-old woman presented with missed abortion at 10 wk of estimated clinical gestational age and underwent dilation and curettage. Gross and microscopic evaluation of the uterine contents revealed the presence of mildly hydropic, dysmorphic chorionic villi, with occasional trophoblastic pseudo-inclusions. The morphologic features raised the suspicion for partial hydatidiform mole, and DNA genotyping was performed using the AmpFlSTR Identifiler PCR Amplification system. The chorionic villous tissue showed unique alleles - not present in the maternal decidual tissue - at 12 of the 15 short tandem repeat loci, and 8 loci showed 2 unique alleles, suggesting a diandric, paternal-only genome. In contrast, p57 immunohistochemistry demonstrated a normal staining pattern with positive nuclear staining in villous stromal cells and cytotrophoblasts. Review of the patient's medical records revealed that the pregnancy was conceived through in vitro fertilization with egg donor embryos, explaining the presence of unexpected alleles simulating a dispermic complete mole on DNA genotyping. This is the first case report illustrating that an egg donor pregnancy may mimic a complete hydatidiform mole on DNA genotyping. PMID:25083967

  7. Structural, magnetic and microwave properties of barium hexaferrite thick films with different Fe/Ba mole ratio

    Energy Technology Data Exchange (ETDEWEB)

    Verma, Samiksha [School of Physics and Materials Science, Thapar University, Patiala 147004 (India); Dhawan, S.K. [Polymeric & Soft Materials Section, National Physical laboratory, New Delhi 119912 (India); Paesano, Andrea [Departamento de Fisica, Universidade Estadual de Maringá, Av. Colombo 5790, Maringá (Brazil); Pandey, O.P. [School of Physics and Materials Science, Thapar University, Patiala 147004 (India); Sharma, Puneet, E-mail: puneet.sharma@thapar.edu [School of Physics and Materials Science, Thapar University, Patiala 147004 (India)

    2015-12-15

    Barium hexaferrite (BaFe{sub 12}O{sub 19}) thick films (∼60 µm) with different BaO·xFe{sub 2}O{sub 3} mole ratio (x=5.0–6.0) were prepared by screen printing method. X-ray diffraction analysis confirmed the formation of single phase BaFe{sub 12}O{sub 19} (BaM). Preferential site occupation of Fe{sup 3+} ion at five different crystallographic sites, with varied mole ratio was measured by Mössbauer spectroscopy. Vacancy fraction found to be higher at 4f{sub 1}, 4f{sub 2} and 2b sites for mole ratio 5.5 and 5.0 respectively. Magnetic measurement shows that the magnetization (M) and magnetocrystalline anisotropy field (H{sub a}) depends upon mole ratio. M and H{sub a} are found to be maximum for mole ratio 5.5, while the coercivity (H{sub c}) remains constant. Reflection losses (R{sub L}) in the frequency range of 12–18 GHz were also studied. Present investigation demonstrates the effect of mole ratio on structural, magnetic and microwave absorption properties of BaM thick films for microwave device applications. - Highlights: • Single phase BaM thick films with different Fe/Ba mole ratio are prepared. • Site preference of Fe ion is estimated by Mössbauer spectroscopy. • Magnetization and magnetocrystalline ansisotropy is found maximum for 5.5 mole ratio. • Absorption frequency found to vary with the mole ratio.

  8. Clinical Usefulness of Immunohistochemical Staining of p57kip2 for the Differential Diagnosis of Complete Mole

    OpenAIRE

    Shigeru Sasaki; Yasushi Sasaki; Toshiaki Kunimura; Akihiko Sekizawa; Yoshihiro Kojima; Koichi Iino

    2015-01-01

    Objective. Can polymer-based immunohistochemical staining of p57kip2 replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? Methods and Materials. Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and examined by immunohistochemical staining of p57kip2. Results. Four of the 14 cases showed clearly negative nuclear staining in cytotrophoblasts and villous stromal cells: these result...

  9. Variação anatômica radial do lenho de açoita-cavalo (Luehea divaricata e sua influência na densidade aparente. Radial variation of wood anatomy in açoita-cavalo (Luehea divaricata and its influence on the specific gravity.

    Directory of Open Access Journals (Sweden)

    Eduardo Luiz LONGUI

    2009-12-01

    Full Text Available Variações entre as dimensões e frequênciasdas células da madeira existem entre espéciesdiferentes, entre indivíduos da mesma espécie ouainda dentro da mesma árvore nas direções radial eaxial. Essa variação influencia diretamente nadensidade aparente e consequentemente no uso dasdiferentes madeiras. O presente estudo determinoua variação anatômica radial e sua influência nadensidade aparente no lenho de árvores de Luehea divaricata, a partir de amostras coletadas no DAP,por meio de método destrutivo. Para a avaliaçãoanatômica e da densidade aparente foram empregadastécnicas usuais em anatomia e propriedades físicasda madeira e os dados tratados estatisticamente.Os resultados revelaram que o diâmetro dos vasos,espessura da parede das fibras e a densidadeaparente foram significativamente menores na regiãoda medula, já o lume das fibras foi significativamentemaior nesta região, que também apresentou raiosmais volumosos. Sugere-se que fibras com paredesmais finas e raios com maior volume na região damedula contribuíram de forma determinante paraos menores valores de densidade aparente.Variations between the size and frequencyof the wood cells occur among differentspecies, trees of the same species or even withinthe same tree in the radial and axial directions.These variations affect directly the specific gravityand consequently the use of different woods.This study determined the radial anatomicalvariation and its influence on specific gravity ofthe wood of Luehea divaricata trees, from samplescollected on DBH by using destructive method.For the evaluation of anatomical characteristicsand specific gravity were employed standardtechniques in anatomy and physical propertiesof wood and the data analyzed statistically.The results revealed significantly lower vesseldiameter, fiber wall thickness and specific gravityin pith, fiber lumen was significantly higher inthis region, which also showed very large rays.It is suggested

  10. Multidimensional MRI-CT atlas of the naked mole-rat brain

    Directory of Open Access Journals (Sweden)

    Fumiko Seki

    2013-12-01

    Full Text Available Naked mole-rats have a variety of distinctive features such as the organisation of a hierarchical society (known as eusociality, extraordinary longevity, and cancer resistance; thus, it would be worthwhile investigating these animals in detail. One important task is the preparation of a brain atlas database that provide comprehensive information containing multidimensional data with various image contrasts, which can be achievable using a magnetic resonance imaging (MRI. Advanced MRI techniques such as diffusion tensor imaging (DTI, which generates high contrast images of fibre structures, can characterise unique morphological properties in addition to conventional MRI. To obtain high spatial resolution images, MR histology, DTI, and X-ray computed tomography (CT were performed on the fixed adult brain. Skull and brain structures were segmented as well as reconstructed in stereotaxic coordinates. Data were also acquired for the neonatal brain to allow developmental changes to be observed. Moreover, in vivo imaging of naked mole-rats was established as an evaluation tool of live animals. The data obtained comprised three-dimensional (3D images with high tissue contrast as well as stereotaxic coordinates. Developmental differences in the visual system were highlighted in particular by DTI. Although it was difficult to delineate optic nerves in the mature adult brain, parts of them could be distinguished in the immature neonatal brain. From observation of cortical thickness, possibility of high somatosensory system development replaced to the visual system was indicated. 3D visualisation of brain structures in the atlas as well as the establishment of in vivo imaging would promote neuroimaging researches towards detection of novel characteristics of eusocial naked mole-rats.

  11. The effect of carbon mole ratio on the fabrication of silicon carbide

    OpenAIRE

    Sutham Niyomwas

    2008-01-01

    Silicon Carbide (SiC) particles were synthesized by self-propagating high temperature synthesis (SHS) from a powder mixture of SiO2-C-Mg. The reaction was carried out in a SHS reactor under static argon gas at a pressure of 0.5 MPa. The standard Gibbs energy minimization method was used to calculate the equilibrium composition of the reacting species. The effects of carbon mole ratio on the precursor mixture (C/SiO2/Mg: 1/1/2 to 3/1/2) and on the SiC conversion were investigated using X-ray d...

  12. [Fourth part of:] Gibraltar from end of Old [mistitled] Mole. c.1880

    OpenAIRE

    Unknown

    2003-01-01

    Second part of a panoramic view composed of 5 joined prints, cloth-backed. The panorama shows a view looking towards the south part of the town from the New Mole. At the right of the photograph ships and hulks are moored at the dockyard with the town beyond. Among the prominent buildings identifiable are the South Barracks behind the town, the Barrack Chapel directly in front, and the Station Hospital on the skyline at the right of the picture. The panorama follows the sea wall and the Ro...

  13. [Third part of:] Gibraltar from end of Old [mistitled] Mole. c.1880

    OpenAIRE

    Unknown

    2003-01-01

    Second part of a panoramic view composed of 5 joined prints, cloth-backed. The panorama shows a view looking towards the south part of the town from the New Mole. At the right of the photograph ships and hulks are moored at the dockyard with the town beyond. Among the prominent buildings identifiable are the South Barracks behind the town, the Barrack Chapel directly in front, and the Station Hospital on the skyline at the right of the picture. The panorama follows the sea wall and the Ro...

  14. [Second part of:] Gibraltar from end of Old [mistitled] Mole. c.1880

    OpenAIRE

    Unknown

    2003-01-01

    Second part of a panoramic view composed of 5 joined prints, cloth-backed. The panorama shows a view looking towards the south part of the town from the New Mole. At the right of the photograph ships and hulks are moored at the dockyard with the town beyond. Among the prominent buildings identifiable are the South Barracks behind the town, the Barrack Chapel directly in front, and the Station Hospital on the skyline at the right of the picture. The panorama follows the sea wall and the Ro...

  15. [First part of:] Gibraltar from end of Old [mistitled] Mole. circa 1880

    OpenAIRE

    Unknown

    2003-01-01

    First part of a panoramic view composed of 5 joined prints, cloth-backed. The panorama shows a view looking towards the south part of the town from the New Mole. At the right of the photograph ships and hulks are moored at the dockyard with the town beyond. Among the prominent buildings identifiable are the South Barracks behind the town, the Barrack Chapel directly in front, and the Station Hospital on the skyline at the right of the picture. The panorama follows the sea wall and the Ros...

  16. [Fifth part of:] Gibraltar from end of Old [mistitled] Mole. c.1880

    OpenAIRE

    Unknown

    2003-01-01

    Second part of a panoramic view composed of 5 joined prints, cloth-backed. The panorama shows a view looking towards the south part of the town from the New Mole. At the right of the photograph ships and hulks are moored at the dockyard with the town beyond. Among the prominent buildings identifiable are the South Barracks behind the town, the Barrack Chapel directly in front, and the Station Hospital on the skyline at the right of the picture. The panorama follows the sea wall and the Ro...

  17. Ultrasound imaging of partial hydatidiform mole in the second trimester of pregnancy

    International Nuclear Information System (INIS)

    The case report of a 27 year-old patient with 18 weeks gestation, admitted to the Obstetrics Department of 'Mariana Grajales Coello' Provincial Gynecology and Obstetrics Hospital of Santiago de Cuba due to high blood pressure, cephalea and pain in lower abdomen is described. Additional tests confirmed a partial hydatidiform mole, so that uterine curettage was performed and small fragments of endometrial stroma were removed for pathological study. Outpatient medical monitoring was recommended and the patient had an appointment at 21 days for controlling and evaluating her general state

  18. High accuracy measurements of dry mole fractions of carbon dioxide and methane in humid air

    OpenAIRE

    Rella, C. W.; H Chen; A. E. Andrews; A. Filges; C. Gerbig; Hatakka, J.; A. Karion; N. L. Miles; Richardson, S. J.; M. Steinbacher; C. Sweeney; Wastine, B.; Zellweger, C.

    2012-01-01

    Traditional techniques for measuring the mole fractions of greenhouse gas in the well-mixed atmosphere have required extremely dry sample gas streams (dew point < −25 °C) to achieve the inter-laboratory compatibility goals set forth by the Global Atmospheric Watch program of the World Meteorological Organization (WMO/GAW) for carbon dioxide (±0.1 ppm) and methane (±2 ppb). Drying the sample gas to low levels of water vapor can be expensive, time-consuming, and/or problematic, especial...

  19. Estimation of alkali metal mole percent and weight of calcined solids for ICPP calcine

    International Nuclear Information System (INIS)

    An updated method is given for estimation of the weight of calcined solids and volume reduction factor for calcine, and mole percent sodium plus potassium in calcine produced from radioactive waste in a fluidized-bed calciner at the Idaho Chemical Processing Plant (ICPP). It incorporates new information on a calcine chemistry from a study by K. N. Brewer and G. F. Kessinger in which they determined the compounds formed during calcination by both high temperature thermodynamic equilibrium calculations and by analyses of pilot-plant calcines. An explanation of the assumptions made in the calculations, along with several example calculations and comparisons with the previous calculation methods are included. This method allows calculation of the heat generation rate and sodium content of the calcine, which are used to determine the suitability of the calcine for storage in the ICPP bin sets. Although this method accurately predicts the weight of calcine and mole percent Na + K for its intended purpose, the compounds predicted should only be used as a first approximation for other purposes since the calculation does not incorporate all of the compounds, such as mixed-metal oxides, which may form during calcination

  20. Resonant Spin-Flavor Conversion of Supernova Neutrinos: Dependence on Electron Mole Fraction

    CERN Document Server

    Yoshida, T; Kimura, K; Yokomakura, H; Kawagoe, S; Kajino, T

    2009-01-01

    Detailed dependence of resonant spin-flavor (RSF) conversion of supernova neutrinos on electron mole fraction Ye is investigated. Supernova explosion forms a hot-bubble and neutrino-driven wind region of which electron mole fraction exceeds 0.5 in several seconds after the core collapse. When a higher resonance of the RSF conversion is located in the innermost region, flavor change of the neutrinos strongly depends on the sign of 1-2Ye. At an adiabatic high RSF resonance the flavor conversion of bar{nu}_e -> nu_{mu,tau} occurs in Ye 0.5 and inverted mass hierarchy. In other cases of Ye values and mass hierarchies, the conversion of nu_e -> bar{nu}_{mu,tau} occurs. The final bar{nu}_e spectrum is evaluated in the cases of Ye 0.5 taking account of the RSF conversion. Based on the obtained result, time variation of the event number ratios of low bar{nu}_e energy to high bar{nu}_e energy is discussed. In normal mass hierarchy, an enhancement of the event ratio should be seen in the period when the electron frac...

  1. High accuracy measurements of dry mole fractions of carbon dioxide and methane in humid air

    Directory of Open Access Journals (Sweden)

    C. W. Rella

    2013-03-01

    Full Text Available Traditional techniques for measuring the mole fractions of greenhouse gases in the well-mixed atmosphere have required dry sample gas streams (dew point inter-laboratory compatibility goals (WMO, 2011a without drying the sample gas. In this paper, we present laboratory methodology for empirically deriving the water vapour correction factors, and we summarise a series of in-situ validation experiments comparing the measurements in humid gas streams to well-characterised dry-gas measurements. By using the manufacturer-supplied correction factors, the dry-mole fraction measurements have been demonstrated to be well within the GAW compatibility goals up to a water vapour concentration of at least 1%. By determining the correction factors for individual instruments once at the start of life, this water vapour concentration range can be extended to at least 2% over the life of the instrument, and if the correction factors are determined periodically over time, the evidence suggests that this range can be extended up to and even above 4% water vapour concentrations.

  2. Adaptations to a Subterranean Environment and Longevity Revealed by the Analysis of Mole Rat Genomes

    Directory of Open Access Journals (Sweden)

    Xiaodong Fang

    2014-09-01

    Full Text Available Subterranean mammals spend their lives in dark, unventilated environments that are rich in carbon dioxide and ammonia and low in oxygen. Many of these animals are also long-lived and exhibit reduced aging-associated diseases, such as neurodegenerative disorders and cancer. We sequenced the genome of the Damaraland mole rat (DMR, Fukomys damarensis and improved the genome assembly of the naked mole rat (NMR, Heterocephalus glaber. Comparative genome analyses, along with the transcriptomes of related subterranean rodents, revealed candidate molecular adaptations for subterranean life and longevity, including a divergent insulin peptide, expression of oxygen-carrying globins in the brain, prevention of high CO2-induced pain perception, and enhanced ammonia detoxification. Juxtaposition of the genomes of DMR and other more conventional animals with the genome of NMR revealed several truly exceptional NMR features: unusual thermogenesis, an aberrant melatonin system, pain insensitivity, and unique processing of 28S rRNA. Together, these genomes and transcriptomes extend our understanding of subterranean adaptations, stress resistance, and longevity.

  3. Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P

    Directory of Open Access Journals (Sweden)

    Lewin Gary R

    2010-05-01

    Full Text Available Abstract Recent research has proposed a pathway in which sensory neurons expressing the capsaicin activated ion channel TRPV1 are required for histamine-induced itch and subsequent scratching behavior. We examined histamine-induced itch in the African naked mole-rat (Heterocephalus glaber and found that although naked mole-rats display innate scratching behavior, histamine was unable to evoke increased scratching as is observed in most mouse strains. Using calcium imaging, we examined the histamine sensitivity of naked mole-rat dorsal root ganglia (DRG neurons and identified a population of small diameter neurons activated by histamine, the majority of which are also capsaicin-sensitive. This suggested that naked mole-rat sensory neurons are activated by histamine, but that spinal dorsal horn processing of sensory information is not the same as in other rodents. We have previously shown that naked mole-rats naturally lack substance P (SP in cutaneous C-fibers, but that the neurokinin-1 receptor is expressed in the superficial spinal cord. This led us to investigate if SP deficiency plays a role in the lack of histamine-induced scratching in this species. After intrathecal administration of SP into the spinal cord we observed robust scratching behavior in response to histamine injection. Our data therefore support a model in which TRPV1-expressing sensory neurons are important for histamine-induced itch. In addition, we demonstrate a requirement for active, SP-induced post-synaptic drive to enable histamine sensitive afferents to drive itch-related behavior in the naked mole-rat. These results illustrate that it is altered dorsal horn connectivity of nociceptors that underlies the lack of itch and pain-related behavior in the naked mole-rat.

  4. AoB PLANTS: origins and features

    OpenAIRE

    Jackson, Michael B.

    2009-01-01

    Introduction AoB PLANTS is a peer reviewed, Open Access (OA) journal owned and run by plant biologists and published by Oxford University Press. The journal publishes research papers, reviews and opinion papers on all aspects of land based plant biology. They are made available rapidly online and can be accessed without the need for subscriptions or payment. Background Several difficulties in conventional publishing of peer-reviewed manuscripts encouraged AoB PLANTS to adopt OA. Open Access h...

  5. Standard Triaxial Ellipsoid Asteroids from AO Observations

    Science.gov (United States)

    Drummond, Jack D.; Merline, W. J.; Conrad, A.; Dumas, C.; Carry, B.

    2008-09-01

    As part of our study of resolved asteroids using adaptive optics (AO) on large telescopes (>8; m), we have identified several that can serve as Standard Triaxial Ellipsoid Asteroids (STEAs), suitable for radar and thermo-physical calibration. These objects are modeled well as triaxial ellipsoids, having: 1) small uncertainties on their three dimensions as determined with AO; 2) rotational poles well determined from both lightcurves and AO; and 3) good sidereal periods from lightcurves. Although AO allows the opportunity to find an asteroid's dimensions and rotational pole in one night, we have developed a method to combine AO observations from different oppositions to pool into a global solution. The apparent orientation and sizes of STEAs can be predicted to within a few degrees and a few km over decades. Currently, we consider 511 Davida, 52 Europa, 2 Pallas, and 15 Eunomia as STEAs. Asteroids that are not well modeled as ellipsoids, clearly showing departures from ellipsoid figures in AO images, include 129 Antigone and 41 Daphne. We will show movies of images and models of these asteroids.

  6. Estimating regional methane surface fluxes: the relative importance of surface and GOSAT mole fraction measurements

    Directory of Open Access Journals (Sweden)

    A. Fraser

    2013-06-01

    Full Text Available We use an ensemble Kalman filter (EnKF, together with the GEOS-Chem chemistry transport model, to estimate regional monthly methane (CH4 fluxes for the period June 2009–December 2010 using proxy dry-air column-averaged mole fractions of methane (XCH4 from GOSAT (Greenhouse gases Observing SATellite and/or NOAA ESRL (Earth System Research Laboratory and CSIRO GASLAB (Global Atmospheric Sampling Laboratory CH4 surface mole fraction measurements. Global posterior estimates using GOSAT and/or surface measurements are between 510–516 Tg yr−1, which is less than, though within the uncertainty of, the prior global flux of 529 ± 25 Tg yr−1. We find larger differences between regional prior and posterior fluxes, with the largest changes in monthly emissions (75 Tg yr−1 occurring in Temperate Eurasia. In non-boreal regions the error reductions for inversions using the GOSAT data are at least three times larger (up to 45% than if only surface data are assimilated, a reflection of the greater spatial coverage of GOSAT, with the two exceptions of latitudes >60° associated with a data filter and over Europe where the surface network adequately describes fluxes on our model spatial and temporal grid. We use CarbonTracker and GEOS-Chem XCO2 model output to investigate model error on quantifying proxy GOSAT XCH4 (involving model XCO2 and inferring methane flux estimates from surface mole fraction data and show similar resulting fluxes, with differences reflecting initial differences in the proxy value. Using a series of observing system simulation experiments (OSSEs we characterize the posterior flux error introduced by non-uniform atmospheric sampling by GOSAT. We show that clear-sky measurements can theoretically reproduce fluxes within 10% of true values, with the exception of tropical regions where, due to a large seasonal cycle in the number of measurements because of clouds and aerosols, fluxes are within 15% of true fluxes. We evaluate our

  7. Ovarian hyperstimulation syndrome in a spontaneous pregnancy with invasive mole: report of a case.

    Science.gov (United States)

    Rachad, Myriam; Chaara, Hikmat; Zahra Fdili, Fatim; Bouguern, Hakima; Melhouf, Abdilah

    2011-01-01

    It is known that most cases of Ovarian Hyperstimulation Syndrome (OHSS) are associated with the therapies for ovulation induction. However, OHSS may rarely be associated with a spontaneous ovulatory cycle, usually in the case of multiple gestations, hypothyroidism or polycystic ovary syndrome. We report a case of severe OHSS in spontaneous pregnancy with invasive mole in a 34 years old woman. The clinical picture showed abdominal pain, massive ascites, nausea, dyspnea and amenorrhea. After imaging examinations and laboratory tests, the diagnosis was established. The patient was managed expectantly with no complications. Although spontaneous ovarian hyperstimulation is a rare entity, it is important that the physician recognizes this condition. Prompt diagnosis and successful management is likely to avoid serious complications, which may develop rapidly. PMID:22355432

  8. Ultrastructural effects of ultraviolet C radiation on the stratum basale of mole rats epidermis

    Directory of Open Access Journals (Sweden)

    Mustafa Yel

    2014-10-01

    Full Text Available The ultrastructure of the epidermis of mole rats (Spalax leucodon was studied after irradiation with ultraviolet (UV light (λmax = 254 nm; 0.00147 J cm−2 s−1; for periods of 52, 112 and 168 h by using transmission electron microscope (TEM. After irradiation, Vacuolation in cytoplasm and mitochondria, and wrinkled nucleus were found in the stratum basal cells. Also, pathological aggregations of tonofilaments are formed in the desmosomes in these cells. These findings clearly demonstrated the harmful effects of ultraviolet C radiation on the stratum basale. The degree of pathological changes occurred depending on exposure time and radiation dosage applied.

  9. The effect of carbon mole ratio on the fabrication of silicon carbide

    Directory of Open Access Journals (Sweden)

    Sutham Niyomwas

    2008-03-01

    Full Text Available Silicon Carbide (SiC particles were synthesized by self-propagating high temperature synthesis (SHS from a powder mixture of SiO2-C-Mg. The reaction was carried out in a SHS reactor under static argon gas at a pressure of 0.5 MPa. The standard Gibbs energy minimization method was used to calculate the equilibrium composition of the reacting species. The effects of carbon mole ratio on the precursor mixture (C/SiO2/Mg: 1/1/2 to 3/1/2 and on the SiC conversion were investigated using X-ray diffraction and scanning electron microscope technique. The as-synthesized products of SiC-MgO powders were leached with 0.1M HCl acid solution to obtain the SiC particles.

  10. Hyaluronan in cancer - from the naked mole rat to nanoparticle therapy.

    Science.gov (United States)

    Rankin, Kenneth S; Frankel, Daniel

    2016-05-01

    Hyaluronan, a glycosaminoglycan, abundant in the tumour microenvironment, is a key player in many processes associated with cancer. Recently the cancer resistance of the naked mole rat has been attributed to the presence of an ultra-high molecular weight form of this molecule. The physical properties of this multifunctional biopolymer have been extensively studied in the context of synovial joints. However, relatively little has been reported with regard to the soft matter properties of hyaluronan in relation to cancer. In this review we examine the role of hyaluronan in cancer, paying particular attention to its mechanical interactions with malignant cells and its soft matter properties. In addition we discuss the use of hyaluronan based gels to study cancer invasion as well as nanoparticle based strategies for disease treatment. PMID:27079782

  11. Effect of Temperature and Mole Ratio on the Synthesis Yield of Rhenium-Tetrofosmin

    Directory of Open Access Journals (Sweden)

    Widyastuti

    2015-08-01

    Full Text Available Technetium-99m (99mTc tetrofosmin is widely used in nuclear medicine as a diagnostic agent for myocardial perfusion and as a tumor imaging agent. As a parenteral preparation it requires an evaluation of its pharmacokinetics and stability in-vivo. Since 99mTc has a short half-life and is only available in very low concentrations, it is impossible to characterize its chemical properties and presence in the body. Due to this reason, only technetium-99 (T1/2 = 5 × 105 years, which is available in macro quantities, or natural rhenium can be used for this purpose. In this study rhenium-188 (188Re tetrofosmin will be synthesized and applied, because non-radioactive Re can be easily obtained. Synthesis and radiochemical purity analysis of carrier-added 188Re-tetrofosmin were carried out as a model to study the in-vivo stability of technetium-99m tetrofosmin. Rhenium-188 was used as a tracer to identify the formation of rhenium tetrofosmin. Rhenium gluconate was synthesized first prior to the formation of rhenium tetrofosmin. The quality of labeling for both rhenium gluconate and rhenium tetrofosmin was analyzed using paper- and thin-layer chromatography, respectively. Rhenium gluconate can be synthesized with high labeling yield within 1 hour, whereas rhenium tetrofosmin was synthesized both in room temperature and in an elevated temperature with various tetrofosmin-to-rhenium mole ratios.The results showed that heating at 95oC led to a higher yield of more than 90% within 30 minutes. Rhenium tetrofosmin could be produced in high radiochemical purity using an excess of tetrofosmin with mole ratio of 2000. It is concluded that rhenium tetrofosmin could be synthesized through the formation of rhenium gluconate, and a higher yield could be obtained in a shorter time by heating process.

  12. Adaptation of pelage color and pigment variations in Israeli subterranean blind mole rats, Spalax ehrenbergi [corrected].

    Directory of Open Access Journals (Sweden)

    Natarajan Singaravelan

    Full Text Available BACKGROUND: Concealing coloration in rodents is well established. However, only a few studies examined how soil color, pelage color, hair-melanin content, and genetics (i.e., the causal chain synergize to configure it. This study investigates the causal chain of dorsal coloration in Israeli subterranean blind mole rats, Spalax ehrenbergi. METHODS: We examined pelage coloration of 128 adult animals from 11 populations belonging to four species of Spalax ehrenbergi superspecies (Spalax galili, Spalax golani, Spalax carmeli, and Spalax judaei and the corresponding coloration of soil samples from the collection sites using a digital colorimeter. Additionally, we quantified hair-melanin contents of 67 animals using HPLC and sequenced the MC1R gene in 68 individuals from all four mole rat species. RESULTS: Due to high variability of soil colors, the correlation between soil and pelage color coordinates was weak and significant only between soil hue and pelage lightness. Multiple stepwise forward regression revealed that soil lightness was significantly associated with all pelage color variables. Pelage color lightness among the four species increased with the higher southward aridity in accordance to Gloger's rule (darker in humid habitats and lighter in arid habitats. Darker and lighter pelage colors are associated with darker basalt and terra rossa, and lighter rendzina soils, respectively. Despite soil lightness varying significantly, pelage lightness and eumelanin converged among populations living in similar soil types. Partial sequencing of the MC1R gene identified three allelic variants, two of which were predominant in northern species (S. galili and S. golani, and the third was exclusive to southern species (S. carmeli and S. judaei, which might have caused the differences found in pheomelanin/eumelanin ratio. CONCLUSION/SIGNIFICANCE: Darker dorsal pelage in darker basalt and terra rossa soils in the north and lighter pelage in rendzina and

  13. High accuracy measurements of dry mole fractions of carbon dioxide and methane in humid air

    Directory of Open Access Journals (Sweden)

    C. W. Rella

    2012-08-01

    Full Text Available Traditional techniques for measuring the mole fractions of greenhouse gas in the well-mixed atmosphere have required extremely dry sample gas streams (dew point < −25 °C to achieve the inter-laboratory compatibility goals set forth by the Global Atmospheric Watch program of the World Meteorological Organization (WMO/GAW for carbon dioxide (±0.1 ppm and methane (±2 ppb. Drying the sample gas to low levels of water vapor can be expensive, time-consuming, and/or problematic, especially at remote sites where access is difficult. Recent advances in optical measurement techniques, in particular Cavity Ring Down Spectroscopy (CRDS, have led to the development of highly stable and precise greenhouse gas analyzers capable of highly accurate measurements of carbon dioxide, methane, and water vapor. Unlike many older technologies, which can suffer from significant uncorrected interference from water vapor, these instruments permit for the first time accurate and precise greenhouse gas measurements that can meet the WMO/GAW inter-laboratory compatibility goals without drying the sample gas. In this paper, we present laboratory methodology for empirically deriving the water vapor correction factors, and we summarize a series of in-situ validation experiments comparing the measurements in humid gas streams to well-characterized dry-gas measurements. By using the manufacturer-supplied correction factors, the dry-mole fraction measurements have been demonstrated to be well within the GAW compatibility goals up to at least 1% water vapor. By determining the correction factors for individual instruments once at the start of life, this range can be extended to at least 2% over the life of the instrument, and if the correction factors are determined periodically over time, the evidence suggests that this range can be extended above 4%.

  14. Gis-approach for variability assessment of soil electric conductivity under pedoturbation activity of mole rat (Spalax microphthalmus

    Directory of Open Access Journals (Sweden)

    T. М. Konovalova

    2010-06-01

    Full Text Available The results of the investigation of the impact of the mole rat’s activity on soil electric conductivity have been presented. GIS-technology have been shown to be effective for assessment of the pedoturbation activity effect on the soil surface heterogeneity formation. Method of the one-dimension spatial coordinated array transformation into matrix form has been proposed for following multidimension statistic analysis application. The quantity estimation of the mole rats role in formation of the habitat nanorelief-level diversity has been obtained by means of indexes of the landscape complexity and diversity.

  15. Efeito da data de sementeira na produtividade de trigo mole (Triticum Aestivum L. em condições mediterrânicas Effect of the sowing date on bread wheat (Triticum Aestivum L. productivity under mediterranean conditions

    Directory of Open Access Journals (Sweden)

    José Manuel Godinho Calado

    2008-01-01

    Full Text Available A data de sementeira do trigo mole exerce uma influência relevante no crescimento e desenvolvimento da cultura, condicionando a sua produtividade. O seu efeito é, especial-mente, importante sob condições mediterrânicas. Por isso, neste trabalho procurou-se verificar a influência da data de sementeira no rendimento do trigo mole, a partir de um ensaio de quinze genótipos semeados em datas diferentes durante cinco anos (1994/95 a 1999/00 na região Alentejo. Com base na análise dos resultados conclui-se que a variação da época de sementeira em aproximadamente um mês, desde o fim de Outubro até ao fim de Novembro, pode permitir rendimentos viáveis do trigo mole nas zonas cerealíferas mediterrânicas, particularmente na região Alentejo. Todavia, as produções mais altas tendem a ser obtidas quando a sementeira é efectuada na primeira quinzena de Novembro. Ao avançar a sementeira para o mês de Dezembro decresce a produtividade e, em consequência, diminui a viabilidade da cultura.The sowing date of bread wheat has a great influence on the growth and development of the crop and its productivity, especially under Mediterranean conditions. This paper presents the results of trials conducted in the Alentejo region that studied the performance of fifteen wheat genotypes sown at different dates, repeated over 5 years (1994/95 to 1999/00. Despite a great variability between years, the results indicate that a satisfactory wheat productivity in the Alentejo can be obtained with sowing dates ranging from end of October until the end of November. Nonetheless, sowing dates in the first half of November tend to provide higher grain yields. Moving the sowing date into December results in reduced grain yields, thus compromising the economic viability of wheat growing.

  16. Revis\\~ao da Constru\\c{c}\\~ao de Modelos Supersim\\'etricos

    CERN Document Server

    Rodríguez, M C

    2001-01-01

    Foi com base neste estudo que fizemos a constru\\c{c}\\~ao da vers\\~ao supersim\\'etrica dos modelos de simetria $SU(3)_{C} \\otimes SU(3)_{L} \\otimes U(1)_{N}$ \\cite{susy331}, apresentado no final da minha tese de doutorado \\cite{mcr1}. Bem como dos estudos fenomenol\\'ogicos subsequente \\cite{mcr}.

  17. Into the Blue: AO Science with MagAO in the Visible

    CERN Document Server

    Close, Laird M; Follette, Katherine B; Hinz, Phil; Morzinski, Katie M; Wu, Ya-Lin; Kopon, Derek; Riccardi, Armando; Esposito, Simone; Puglisi, Alfio; Pinna, Enrico; Xompero, Marco; Briguglio, Runa; Quiros-Pacheco, Fernando

    2014-01-01

    We review astronomical results in the visible ({\\lambda}<1{\\mu}m) with adaptive optics. Other than a brief period in the early 1990s, there has been little astronomical science done in the visible with AO until recently. The most productive visible AO system to date is our 6.5m Magellan telescope AO system (MagAO). MagAO is an advanced Adaptive Secondary system at the Magellan 6.5m in Chile. This secondary has 585 actuators with < 1 msec response times (0.7 ms typically). We use a pyramid wavefront sensor. The relatively small actuator pitch (~23 cm/subap) allows moderate Strehls to be obtained in the visible (0.63-1.05 microns). We use a CCD AO science camera called "VisAO". On-sky long exposures (60s) achieve <30mas resolutions, 30% Strehls at 0.62 microns (r') with the VisAO camera in 0.5" seeing with bright R < 8 mag stars. These relatively high visible wavelength Strehls are made possible by our powerful combination of a next generation ASM and a Pyramid WFS with 378 controlled modes and 1000...

  18. Ao encontro do equilíbrio

    OpenAIRE

    Freitas, Licínia Marisa Oliveira

    2013-01-01

    O presente Relatório apresenta as atividades desenvolvidas ao longo de todo o período de estágio referentes ao módulo I e II. O módulo I teve por base a primeira e segunda fase do Planeamento em Saúde, que se refere ao Diagnóstico de Situação de Saúde da população com patologia de Diabetes Mellitus e Priorização das Necessidades. No módulo II surgiram os projetos de intervenção nas necessidades detetadas e avaliação das mesmas com a verificação dos ganhos em saúde observados. Numa primeira...

  19. Into the blue: AO science with MagAO in the visible

    Science.gov (United States)

    Close, Laird M.; Males, Jared R.; Follette, Katherine B.; Hinz, Phil; Morzinski, Katie; Wu, Ya-Lin; Kopon, Derek; Riccardi, Armando; Esposito, Simone; Puglisi, Alfio; Pinna, Enrico; Xompero, Marco; Briguglio, Runa; Quiros-Pacheco, Fernando

    2014-08-01

    We review astronomical results in the visible (λresponse times (0.7 ms typically). We use a pyramid wavefront sensor. The relatively small actuator pitch (~23 cm/subap) allows moderate Strehls to be obtained in the visible (0.63-1.05 microns). We use a CCD AO science camera called "VisAO". On-sky long exposures (60s) achieve Pyramid WFS with 378 controlled modes and 1000 Hz loop frequency. We'll review the key steps to having good performance in the visible and review the exciting new AO visible science opportunities and refereed publications in both broad-band (r,i,z,Y) and at Halpha for exoplanets, protoplanetary disks, young stars, and emission line jets. These examples highlight the power of visible AO to probe circumstellar regions/spatial resolutions that would otherwise require much larger diameter telescopes with classical infrared AO cameras.

  20. Dynamic Thermodynamics with Internal Energy, Volume, and Amount of Moles as States : Application to Liquefied Gas Tank

    NARCIS (Netherlands)

    Arendsen, A. R. J.; Versteeg, G. F.

    2009-01-01

    Dynamic models for process design, optimization, and control usually solve a set of heat and/or mass balances as a function of time and/or position in the process. To obtain more robust dynamic models and to minimize the amount of assumptions, internal energy, volume, and amount of moles are chosen

  1. Paternity and relatedness in the natural population of the solitary bythyergid, the silvery mole-rat Heliophobius argenteocinereus

    Czech Academy of Sciences Publication Activity Database

    Patzenhauerová, Hana; Bryja, Josef; Šumbera, R.

    2007-01-01

    Roč. 1, Supp. (2007), s. 144. ISSN 1825-5272. [European Congress of Mammalogy /5./. 21.09.2007-26.09.2007, Siena] Institutional research plan: CEZ:AV0Z60930519 Keywords : African mole-rats Subject RIV: EB - Genetics ; Molecular Biology

  2. Effect of mole (Talpaеuropаеa digging activity on soil microflora in case of soil cadmium pollution

    Directory of Open Access Journals (Sweden)

    O. Y. Pakhomov

    2006-01-01

    Full Text Available Influence of fossorial activity of European mole Talpa еuropаеа on number and distribution of soil microorganisms under conditions of cadmium pollution of the soil is characterized. Mammals’ fossorial activity is an important natural ecological factor that contributes to microflora rehabilitation and development under conditions of contamination.

  3. Phylogeny of species and cytotypes of mole rats (Spalacidae) in Turkey inferred from mitochondrial cytochrome b gene sequences

    Czech Academy of Sciences Publication Activity Database

    Kandemir, I.; Sozen, M.; Matur, F.; Kankilic, T.; Martínková, Natália; Colak, F.; Ozkurt, S. O.; Colak, E.

    Paris: Université P. et M. Curie, 2011. s. 5 [European Congress of Mammalogy /7./. 19.07.2011-23.07.2011, Paris] Institutional research plan: CEZ:AV0Z60930519 Keywords : mole rats * phylogeny * Turkey Subject RIV: EG - Zoology http://www.alphavisa.com/ecm2011/pdf/ECM2011-Abstract_Book.pdf

  4. HP3 on ExoMars - Cutting airbag cloths with the sharp tip of a mechanical mole

    Science.gov (United States)

    Krause, C.; Izzo, M.; Re, E.; Mehls, C.; Richter, L.; Coste, P.

    2009-04-01

    The HP3 - Heat Flow and Physical Properties Package - is planned to be one of the Humboldt lander-based instruments on the ESA ExoMars mission. HP3 will allow the measurement of the subsurface temperature gradient and physical as well as thermophysical properties of the subsurface regolith of Mars down to a depth of 5 meters. From these measurements, the planetary heat flux can be inferred. The HP³ instrument package consists of a mole trailing a package of thermal and electrical sensors into the regolith. Beside the payload elements Thermal Excitation and Measurement Suite and a Permittivity Probe the HP3 experiment includes sensors to detect the forward motion and the tilt of the HP3 payload compartment. The HP3 experiment will be integrated into the lander platform of the ExoMars mission. The original accommodation featured a deployment device or a robotic arm to place HP3 onto the soil outside the deflated lander airbags. To avoid adding such deployment devices, it was suggested that the HP3 mole should be capable of piercing the airbags under the lander. The ExoMars lander airbag is made of 4 Kevlar layers (2 abrasive and 2 bladders). A double fold of the airbag (a worst case) would represent a pile of 12 layers. An exploratory study has examined the possibility of piercing airbag cloths by adding sharp cutting blades on the tip of a penetrating mole. In the experimental setup representative layers were laid over a Mars soil simulant. Initial tests used a hammer-driven cutting tip and had moderate to poor results. More representative tests used a prototype of the HP3 mole and were fully successful: the default 4 layer configuration was pierced as well as the 12 layer configuration, the latter one within 3 hours and about 3000 mole strokes This improved behaviour is attributed to the use of representative test hardware where guidance and suppression of mole recoil were concerned. The presentation will provide an explanation of the technical requirements on

  5. Photic induction of Fos in the suprachiasmatic nucleus of African mole-rats: responses to increasing irradiance.

    Science.gov (United States)

    Oosthuizen, Maria K; Bennett, Nigel C; Cooper, Howard M

    2010-09-01

    African mole-rats (family Bathyergidae) are strictly subterranean rodent species that are rarely exposed to environmental light. Morphological and physiological adaptations to the underground environment include a severely reduced eye size and regressed visual system. Responses of the circadian system to light, however, appear to be intact, since mole-rats are able to entrain their circadian activity rhythms to the light-dark cycle and light induces Fos expression in the suprachiasmatic nucleus (SCN). Social organization varies from solitary species to highly elaborated eusocial structures, characterized by a distinct division of labor and in which one reproductive female regulates the behavior and reproductive physiology of other individuals in the colony. The authors studied light-induced Fos expression in the SCN to increasing light intensities in four mole-rat species, ranging from strictly solitary to highly social. In the solitary Cape mole-rat, light induces significant Fos expression in the SCN, and the number of Fos-immunopositive cells increases with increasing light intensity. In contrast, Fos induction in the SCN of social species was slightly greater than, but not statistically different from, the dark-control animals as is typical of most rodents. One species showed a trend for an increase in expression with increased light, whereas a second species showed no trend in expression. In the naked mole-rat, Fos expression appeared higher in the dark-controls than in the animals exposed to light, although the differences in Fos expression were not significant. These results suggest a gradient in the sensitivity of the circadian system to light in mole-rats, with a higher percentage of individuals that are unresponsive to light in correlation with the degree of sociality. In highly social species, such as the naked mole-rat that live in a relatively stable subterranean milieu in terms of food availability, temperature, constant darkness, and devoid of 24-h

  6. Variation of CO2 mole fraction in the lower free troposphere, in the boundary layer and at the surface

    Directory of Open Access Journals (Sweden)

    J. Tarniewicz

    2012-05-01

    Full Text Available Eight years of occasional flask air sampling and 3 yr of frequent in situ measurements of carbon dioxide (CO2 vertical profiles on board of a small aircraft, over a tall tower greenhouse gases monitoring site in Hungary are used for the analysis of the variations of vertical profile of CO2 mole fraction. Using the airborne vertical profiles and the measurements along the 115 m tall tower it is shown that the measurements at the top of the tower estimate the mean boundary layer CO2 mole fraction during the mid-afternoon fairly well, with an underestimation of 0.27–0.85 μmol mol−1 in summer, and an overestimation of 0.66–1.83 μmol mol−1 in winter. The seasonal cycle of CO2 mole fraction is damped with elevation. While the amplitude of the seasonal cycle is 28.5 μmol mol−1 at 10 m above the ground, it is only 10.7 μmol mol−1 in the layer of 2500–3000 m corresponding to the lower free atmosphere above the well-mixed boundary layer. The maximum mole fraction in the layer of 2500–3000 m can be observed around 25 March on average, two weeks ahead of that of the marine boundary layer reference (GLOBALVIEW. By contrast, close to the ground, the maximum CO2 mole fraction is observed late December, early January. The specific seasonal behavior is attributed to the climatology of vertical mixing of the atmosphere in the Carpathian Basin.

  7. ECOPERSONALISMO E DIREITO AO MEIO AMBIENTE

    OpenAIRE

    2008-01-01

    O objetivo do presente artigo consiste em refletir brevemente sobre as conseqüências, no âmbito do direito ao meio ambiente, das diferentes concepções sobre a relação entre o ser humano e a natureza, isto é, o modelo tecnocrático, o biologista e o ecológico-personalista

  8. Into the Blue: AO Science in the Visible with MagAO

    Science.gov (United States)

    Close, Laird; Males, Jared; Morzinski, Katie; Kopon, Derek; Follette, Kate; Rodigas, Timothy; Hinz, Philip; Wu, Ya-Lin; Puglisi, Alfio; Esposito, Simone; Riccardi, Armando; Pinna, Enrico; Xompero, Marco; Briguglio, Runa; Uomoto, Alan; Hare, Tison

    2013-12-01

    The Magellan Clay telescope is a 6.5m Gregorian telescope located in Chile at Las Campanas Observatory. We have fabricated an 85 cm diameter aspheric adaptive secondary with our subcontractors and partners, MagAO passed acceptance tests in spring 2012, and the entire System was commissioned from Nov 17 to Dec 7, 2012. This secondary has 585 actuators with response times (0.7 ms typically). We fabricated a high order (585 mode) pyramid wavefront sensor (similar to that of LBT's FLAO). The relatively high actuator count allows moderate Strehls to be obtained in the visible (0.63-1.05 microns). We have built an CCD science camera called "jVisAO". On-sky long exposures (60s) achieve 30% Strehls at 0.62 microns (r') with the VisAO camera in 0.5" seeing with bright R Pyramid WFS with 200-400 controlled modes and 1000 Hz loop frequencies. To minimize non-common path errors and enable visible AO the VisAO science camera is fed by an advanced triplet ADC and is piggy-backed on the WFS optical board itself. Despite the ability to make 25 mas images we still have ~4 mas of resolution loss to residual vibrations. We will discuss what the most difficult aspects are for visible AO on ELTs scaling from our experience with MagAO.

  9. Characterization of an AO-OCT system

    Energy Technology Data Exchange (ETDEWEB)

    Evans, J W; Zawadzki, R J; Jones, S; Olivier, S; Werner, J S

    2007-07-26

    Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-volumetric-resolution, images of the retina. The AO-OCT system at UC Davis has been under development for 2 years and has demonstrated the utility of this technology for microscopic, volumetric, in vivo retinal imaging [1]. The current system uses an AOptix bimorph deformable mirror (DM) for low-order, high-stroke correction [2] and a 140-actuator Boston Micromachines DM for high-order correction [3]. We are beginning to investigate the potential for increasing the image contrast in this system using higher-order wavefront correction. The first step in this analysis is to quantify the residual wavefront error (WFE) in the current system. Developing an error budget is a common tool for improved performance and system design in astronomical AO systems [4, 5]. The process for vision science systems is also discussed in several texts e.g. [6], but results from this type of analysis have rarely been included in journal articles on AO for vision science. Careful characterization of the AO system will lead to improved performance and inform the design of a future high-contrast system. In general, an AO system error budget must include an analysis of three categories of residual WFE: errors in measuring the phase, errors caused by limitations of the DM(s), and errors introduced by temporal variation. Understanding the mechanisms and relative size of these errors is critical to improving system performance. In this paper we discuss the techniques for characterizing these error sources in the AO-OCT system. It is useful to first calculate an error budget for the simpler case using a model eye, and then add the additional errors introduced for the case of a human subject. Measurement error includes calibration error, wavefront sensor (WFS) CCD noise, and sampling errors. Calibration errors must be measured by an external system. Typically this

  10. Antagonistic Coevolution Drives Whack-a-Mole Sensitivity in Gene Regulatory Networks.

    Directory of Open Access Journals (Sweden)

    Jeewoen Shin

    2015-10-01

    Full Text Available Robustness, defined as tolerance to perturbations such as mutations and environmental fluctuations, is pervasive in biological systems. However, robustness often coexists with its counterpart, evolvability--the ability of perturbations to generate new phenotypes. Previous models of gene regulatory network evolution have shown that robustness evolves under stabilizing selection, but it is unclear how robustness and evolvability will emerge in common coevolutionary scenarios. We consider a two-species model of coevolution involving one host and one parasite population. By using two interacting species, key model parameters that determine the fitness landscapes become emergent properties of the model, avoiding the need to impose these parameters externally. In our study, parasites are modeled on species such as cuckoos where mimicry of the host phenotype confers high fitness to the parasite but lower fitness to the host. Here, frequent phenotype changes are favored as each population continually adapts to the other population. Sensitivity evolves at the network level such that point mutations can induce large phenotype changes. Crucially, the sensitive points of the network are broadly distributed throughout the network and continually relocate. Each time sensitive points in the network are mutated, new ones appear to take their place. We have therefore named this phenomenon "whack-a-mole" sensitivity, after a popular fun park game. We predict that this type of sensitivity will evolve under conditions of strong directional selection, an observation that helps interpret existing experimental evidence, for example, during the emergence of bacterial antibiotic resistance.

  11. Influence of the mole penetrator on measurements of heat flow in lunar subsurface layers

    Science.gov (United States)

    Wawrzaszek, Roman; Drogosz, Michal; Seweryn, Karol; Banaszkiewicz, Marek; Grygorczuk, Jerzy

    Measuring the thermal gradient in subsurface layers is a basic method of determination the heat flux from the interior of a planetary body to its surface. In case of the Moon, such measurements complemented with the results of theoretical analysis and modeling can significantly improve our understanding of the thermal and geological evolution of the Moon. In practice, temperature gradient measurements are performed by at least two sensors located at different depths under the surface. These sensors will be attached to a penetrator [1] or to a cable pulled behind the penetrator. In both cases the object that carries the sensors, e.g. penetrator, perturb temperature measurements. In our study we analyze a case of two thermal sensors attached to the ends of 350mm long penetrator made of a composite material. In agreement with the studies of other authors we have found that the penetrator should be placed at the depth of 2-3 meters, where periodic changes of the temperature due to variation of solar flux at the surface are significantly smaller than the error of temperature measurement. The most important result of our analysis is to show how to deconvolve the real gradient of the temperature from the measurements perturbed by the penetrator body. In this way it will be possible to more accurately determine heat flux in the lunar regolith. [1] Grygorczuk J., Seweryn K., Wawrzaszek R., Banaszkiewicz M., Insertion of a Mole Pene-trator -Experimental Results, /39th Lunar and Planetary Science Conference /League City, Texas 2008

  12. Cryptic sex? Estimates of genome exchange in unisexual mole salamanders (Ambystoma sp.).

    Science.gov (United States)

    Gibbs, H Lisle; Denton, Robert D

    2016-06-01

    Cryptic sex has been argued to explain the exceptional longevity of certain parthenogenetic vertebrate lineages, yet direct measurements of genetic exchange between sexual and apparently parthenogenetic forms are rare. Female unisexual mole salamanders (Ambystoma sp.) are the oldest known unisexual vertebrate lineage (~5 million years), and one hypothesis for their persistence is that allopolyploid female unisexuals periodically exchange haploid genomes 'genome exchange' during gynogenetic reproduction with males from sympatric sexual species. We test this hypothesis by using genome-specific microsatellite DNA markers to estimate the rates of genome exchange between sexual males and unisexual females in two ponds in NE Ohio. We also test the prediction that levels of gene flow should be higher for 'sympatric' (sexual males present) genomes in unisexuals compared to 'allopatric' (sexual males absent) unisexual genomes. We used a model testing framework in the coalescent-based program MIGRATE-N to compare models where unidirectional gene flow is present and absent between sexual species and unisexuals. As predicted, our results show higher levels of gene flow between sexuals and sympatric unisexual genomes compared to lower (likely artefactual) levels of gene flow between sexuals and allopatric unisexual genomes. Our results provide direct evidence that genome exchange between sexual and unisexual Ambystoma occurs and demonstrate that the magnitude depends on which sexual species are present. The relatively high levels of gene flow suggest that unisexuals must be at a selective advantage over sexual forms so as to avoid extinction due to genetic swamping through genome exchange. PMID:27100619

  13. Large-Scale DNS of Gas-Solid Flow on Mole-8.5

    CERN Document Server

    Xiong, Qingang; Li, Bo; Xua, Ji; Fang, Xiaojian; Wang, Junwu; He, Xianfeng; Wang, Xiaowei; Wang, Limin; Ge, Wei; Li, Jinghai

    2010-01-01

    Direct numerical simulation (DNS) for gas-solid flow is implemented on a multi-scale supercomputing system, Mole-8.5, featuring massive parallel GPU-CPU hybrid computing, for which the lattice Boltzmann method (LBM) is deployed together with the immersed moving boundary (IMB) method and discrete element method (DEM). A two-dimensional suspension with about 1,166,400 75-micron solid particles distributed in an area of 11.5cm x46cm, and a three-dimensional suspension with 129,024 solid particles in a domain of 0.384cm x1.512cm x0.384cm are fully-resolved below particle scale and distinct multi-scale heterogeneity are observed. Almost 20-fold speedup is achieved on one Nvidia C2050 GPU over one core of Intel E5520 CPU in double precision, and nearly ideal scalability is maintained when using up to 672 GPUs. The simulations demonstrate that LB-IMB-DEM modeling with parallel GPU computing may suggest a promising approach for exploring the fundamental mechanisms and constitutive laws of complex gas-solid flow, whic...

  14. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats

    Science.gov (United States)

    Miyawaki, Shingo; Kawamura, Yoshimi; Oiwa, Yuki; Shimizu, Atsushi; Hachiya, Tsuyoshi; Bono, Hidemasa; Koya, Ikuko; Okada, Yohei; Kimura, Tokuhiro; Tsuchiya, Yoshihiro; Suzuki, Sadafumi; Onishi, Nobuyuki; Kuzumaki, Naoko; Matsuzaki, Yumi; Narita, Minoru; Ikeda, Eiji; Okanoya, Kazuo; Seino, Ken-ichiro; Saya, Hideyuki; Okano, Hideyuki; Miura, Kyoko

    2016-01-01

    The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs) and find that NMR-iPSCs do not exhibit teratoma-forming tumorigenicity due to the species-specific activation of tumour-suppressor alternative reading frame (ARF) and a disruption mutation of the oncogene ES cell-expressed Ras (ERAS). The forced expression of Arf in mouse iPSCs markedly reduces tumorigenicity. Furthermore, we identify an NMR-specific tumour-suppression phenotype—ARF suppression-induced senescence (ASIS)—that may protect iPSCs and somatic cells from ARF suppression and, as a consequence, tumorigenicity. Thus, NMR-specific ARF regulation and the disruption of ERAS regulate tumour resistance in NMR-iPSCs. Our findings obtained from studies of NMR-iPSCs provide new insight into the mechanisms of tumorigenicity in iPSCs and cancer resistance in the NMR. PMID:27161380

  15. Functional characteristics of the naked mole rat μ-opioid receptor.

    Directory of Open Access Journals (Sweden)

    Melanie Busch-Dienstfertig

    Full Text Available While humans and most animals respond to µ-opioid receptor (MOR agonists with analgesia and decreased aggression, in the naked mole rat (NMR opioids induce hyperalgesia and severe aggression. Single nucleotide polymorphisms in the human mu-opioid receptor gene (OPRM1 can underlie altered behavioral responses to opioids. Therefore, we hypothesized that the primary structure of the NMR MOR may differ from other species. Sequencing of the NMR oprm1 revealed strong homology to other mammals, but exposed three unique amino acids that might affect receptor-ligand interactions. The NMR and rat oprm1 sequences were cloned into mammalian expression vectors and transfected into HEK293 cells. Radioligand binding and 3'-5'-cyclic adenosine monophosphate (cAMP enzyme immunoassays were used to compare opioid binding and opioid-mediated cAMP inhibition. At normalized opioid receptor protein levels we detected significantly lower [3H]DAMGO binding to NMR compared to rat MOR, but no significant difference in DAMGO-induced cAMP inhibition. Strong DAMGO-induced MOR internalization was detectable using radioligand binding and confocal imaging in HEK293 cells expressing rat or NMR receptor, while morphine showed weak or no effects. In summary, we found minor functional differences between rat and NMR MOR suggesting that other differences e.g. in anatomical distribution of MOR underlie the NMR's extreme reaction to opioids.

  16. Hormones, reproduction and disease in the longest-lived rodent: the naked mole rat

    Directory of Open Access Journals (Sweden)

    Manlio Vinciguerra

    2011-05-01

    Full Text Available Aging is an inescapable human condition, made of hormonal, physical, and behavioral changes. Age-related illnesses and decline result from the interactions between genes and the environment. Life expectancy dramatically increased in the last century with the improvement in health cares and quality of life in the Western World. Despite these advances, the last 20 years of our life are often accompanied by an increased incidence of hormonalrelated diseases, such as cancer, metabolic, cardiovascular and neurological dysturbances. Aging research recently uncovered many of the molecular pathways involved in nutrients and hormonal regulation, and also involved in organism life span using simple laboratory animal model. However this knowledge did not translate in an ameliorated aging and cure for hormonal diseases in humans. A breakthrough in aging research came from recent studies on the longest-lived rodent [the naked mole rat (NMR]. NMR are able to reach ~30 years of age in good health. Because of their longevity and sustained health, NMR are a research model for successful aging. The most striking feature of NMR is perhaps their eusociality. Unique among mammals (eusociality is observed in insects such as bees and ants, NMR are organized in highly cooperative colonies. The aim of this review is to summarize our knowledge on hormonal and reproductive aspects in NMR. Furthermore, their resistance to pathological insults will be discussed.

  17. Ectoparasite Burdens of the Damaraland Mole-Rat (Fukomys damarensis) from Southern Africa.

    Science.gov (United States)

    Lutermann, Heike; Carpenter-Kling, Tegan; Ueckermann, Edward A; Gutjahr, Gundula; Bennett, Nigel C

    2015-12-01

    Damaraland mole-rats (Fukomys damarensis) of the family Bathyergidae are widely distributed subterranean rodents in sub-Saharan Africa. No parasites have ever been reported for this species and only 1 ectoparasite is described for the entire genus. In the current study ectoparasites were collected from individuals captured at 3 localities in South Africa and Namibia to document the ectoparasite community of F. damarensis, investigate their aggregation patterns, and evaluate the influence of season on ectoparasite burden. A total of 2,071 arthropods from 9 mite taxa and 1 louse species (Eulinognathus hilli) were collected from 293 hosts sampled. Of these, 5 mite species (Androlaelaps scapularis, Androlaelaps capensis, Androlaelaps tauffliebi, Radfordia sp., and unidentified chiggers) and the louse were parasites while the remainder was soil mites. All ectoparasites were highly aggregated and the species richness as well as the prevalence and abundance of 4 of them were significantly greater in summer compared to winter, possibly as a result of seasonal changes in rainfall patterns affecting the ectoparasites, host behavior, or both. PMID:26249137

  18. Protocol for the MoleMate™ UK Trial: a randomised controlled trial of the MoleMate system in the management of pigmented skin lesions in primary care [ISRCTN 79932379

    Directory of Open Access Journals (Sweden)

    Wilson Edward CF

    2010-05-01

    Full Text Available Abstract Background Suspicious pigmented lesions are a common presenting problem in general practice consultations; while the majority are benign a small minority are melanomas. Differentiating melanomas from other pigmented lesions in primary care is challenging: currently, 95% of all lesions referred to a UK specialist are benign. The MoleMate system is a new diagnostic aid, incorporating a hand-held SIAscopy scanner with a primary care diagnostic algorithm. This trial tests the hypothesis that adding the MoleMate system to current best primary care practice will increase the proportion of appropriate referrals of suspicious pigmented lesions to secondary care compared with current best practice alone. Methods/design The MoleMate UK Trial is a primary care based multi-centre randomised controlled trial, with randomisation at patient level using a validated block randomisation method for two age groups (45 years and under; 46 years and over. We aim to recruit adult patients seen in general practice with a pigmented skin lesion that cannot immediately be diagnosed as benign and the patient reassured. The trial has a 'two parallel groups' design, comparing 'best practice' with 'best practice' plus the MoleMate system in the intervention group. The primary outcome is the positive predictive value (PPV of referral defined as the proportion of referred lesions seen by secondary care experts that are considered 'clinically significant' (i.e. biopsied or monitored. Secondary outcomes include: the sensitivity, specificity and negative predictive value (NPV of the decision not to refer; clinical outcomes (melanoma thickness, 5 year melanoma incidence and mortality; clinician outcomes (Index of Suspicion, confidence, learning effects; patient outcomes (satisfaction, general and cancer-specific worry, and cost-utility. Discussion The MoleMate UK Trial tests a new technology designed to improve the management of suspicious pigmented lesions in primary care

  19. FATORES ASSOCIADOS AO BAIXO PESO AO NASCER NO ESTADO DE GOIÁS

    Directory of Open Access Journals (Sweden)

    Ruth Minamisava

    2004-12-01

    Full Text Available Recém-nascidos de baixo peso ao nascer (RNBP são considerados problemas de saúde pública pela associação com altas taxas de mortalidade e morbidade. Nenhum estudo prévio sobre fatores associados ao RNBP na região central do Brasil foi encontrado na literatura. Assim, este estudo teve como objetivo identificar as prevalências e os fatores associados ao baixo peso ao nascer entre nascidos vivos no Estado de Goiás, Brasil. Foi realizado um estudo transversal tendo como fonte de dados o Sistema de Informações de Nascidos Vivos ligado ao Ministério da Saúde. Examinou-se todos os 92.745 recém-nascidos de gestação única residentes no estado de Goiás, no ano 2000. Usou-se análise de regressão logística para identificar os fatores associados ao RNBP (< 2500 g. Em Goiás, os RNBP apresentaram uma prevalência de 5,96% e os fatores associados ao baixo peso ao nascer foram: prematuridade, baixa e avançada idade materna, mulheres não casadas, menos de sete consultas de pré-natal, parto não hospitalar e neonatos do sexo feminino. Ações intersetoriais são necessárias para reduzir as desigualdades da saúde materna e infantil.

  20. Experimental comparison of Wide Field AO control schemes using the Homer AO bench.

    Science.gov (United States)

    Parisot, Amélie; Petit, Cyril; Fusco, Thierry

    2011-09-01

    Wide Field Adaptive Optics (WFAO) concepts, such as Laser Tomography AO (LTAO) or Multi-Conjugate AO (MCAO) have been developed in order to overcome the anisoplanatism limit of classical AO. Most of the future AO-assisted instruments of ELTs rely on such concepts which have raised critical challenges such as tomographic estimation and from laser and natural guide star combined with efficient DM(s) control. In that context, the experimental validation of the various clever control solutions proposed by several teams in the past years is now essential to reach a level of maturity compatible with their implementation in future WFAO developments for ELT. The ONERA wide field AO facility (HOMER bench) has been developed for these very issues. Gathering a 3D turbulence generator, laser and natural guide stars, two deformable mirrors with variable altitude positions and a PC-based flexible and user-friendly RTC , HOMER allows the implementation and comparison of control schemes from the simplest least-square to the optimal Linear Quadratic Gaussian solutions including Virtual DM and Pseudo-closed loop approaches. After a description of the bench internal calibrations and ultimate performance, all the control schemes are compared experimentally. Their evolutions as a function of wavefront sensors SNR as well as their robustness to calibration / model errors are particularly emphasised. Finally, we derive from the previous works some specific calibrations and identifications procedures ensuring both robustness and efficiency of WFAO systems and we extrapolate their applications to the future ELT AO systems.

  1. The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

    Science.gov (United States)

    Brohus, Malene; Gorbunova, Vera; Faulkes, Chris G; Overgaard, Michael T; Conover, Cheryl A

    2015-01-01

    Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs) have pluripotent actions, influencing growth processes in virtually every system of the body. They are established contributors to the aging process, confirmed by the demonstration that decreased IGF signaling results in life-extending effects in a variety of species. The IGFs are likewise involved in progression of cancers by mediating survival signals in malignant cells. This report presents a full characterization of the IGF system in the NMR: ligands, receptors, IGF binding proteins (IGFBPs), and IGFBP proteases. A particular emphasis was placed on the IGFBP protease, pregnancy-associated plasma protein-A (PAPP-A), shown to be an important lifespan modulator in mice. Comparisons of IGF-related genes in the NMR with human and murine sequences indicated no major differences in essential parts of the IGF system, including PAPP-A. The protease was shown to possess an intact active site despite the report of a contradictory genome sequence. Furthermore, PAPP-A was expressed and translated in NMRs cells and retained IGF-dependent proteolytic activity towards IGFBP-4 and IGF-independent activity towards IGFBP-5. However, experimental data suggest differential regulatory mechanisms for PAPP-A expression in NMRs than those described in humans and mice. This overall description of the IGF system in the NMR represents an initial step towards elucidating the complex molecular mechanisms underlying longevity, and how these animals have evolved to ensure a delayed and healthy aging process. PMID:26694858

  2. The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

    Directory of Open Access Journals (Sweden)

    Malene Brohus

    Full Text Available Naked mole-rats (Heterocephalus glaber (NMRs are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs have pluripotent actions, influencing growth processes in virtually every system of the body. They are established contributors to the aging process, confirmed by the demonstration that decreased IGF signaling results in life-extending effects in a variety of species. The IGFs are likewise involved in progression of cancers by mediating survival signals in malignant cells. This report presents a full characterization of the IGF system in the NMR: ligands, receptors, IGF binding proteins (IGFBPs, and IGFBP proteases. A particular emphasis was placed on the IGFBP protease, pregnancy-associated plasma protein-A (PAPP-A, shown to be an important lifespan modulator in mice. Comparisons of IGF-related genes in the NMR with human and murine sequences indicated no major differences in essential parts of the IGF system, including PAPP-A. The protease was shown to possess an intact active site despite the report of a contradictory genome sequence. Furthermore, PAPP-A was expressed and translated in NMRs cells and retained IGF-dependent proteolytic activity towards IGFBP-4 and IGF-independent activity towards IGFBP-5. However, experimental data suggest differential regulatory mechanisms for PAPP-A expression in NMRs than those described in humans and mice. This overall description of the IGF system in the NMR represents an initial step towards elucidating the complex molecular mechanisms underlying longevity, and how these animals have evolved to ensure a delayed and healthy aging process.

  3. Comparison of the regional CO2 mole fraction filtering approaches at a WMO/GAW regional station in China

    Science.gov (United States)

    Fang, S. X.; Tans, P. P.; Steinbacher, M.; Zhou, L. X.; Luan, T.

    2015-12-01

    The identification of atmospheric CO2 observation data which are minimally influenced by very local emissions/removals is essential for trend analysis, for the estimation of regional sources and sinks, and for the modeling of long-range transport of CO2. In this study, four approaches are used to filter the atmospheric CO2 observation records from 2009 to 2011 at one World Meteorological Organization/Global Atmosphere Watch (WMO/GAW) regional station (Lin'an, LAN) in China. The methods are based on the concentration of atmospheric black carbon (BC), on a statistical approach (robust extraction of baseline signal, REBS), on CH4 as an auxiliary tracer (AUX), and on meteorological parameters (MET). All approaches do suitably well to capture the seasonal CO2 cycle at LAN. Differences are observed in the average regional mole fractions with annual values in the REBS method at least 1.7 ± 0.2 ppm higher than the other methods. The BC method may underestimate the regional CO2 mole fractions during the winter-spring period and should be treated with caution. The REBS method is a purely statistical method and it may also introduce errors on the regional CO2 mole fraction evaluations, as the filtered trend may be influenced by the "noisy" raw data series. Although there are correlations between CH4 and CO2 mole fractions at LAN, the different source/sink regimes may introduce bias on the regional CO2 estimation in the AUX method, typically in summer. Overall, the MET method seems to be the most favorable because it mainly focuses on the influence of potential local sources and sinks, and considers diurnal variations and meteorological conditions. Using the MET method, the annual growth rate of regional CO2 at LAN is determined to be 3.1 ± 0.01 ppm yr-1 (standard error) from 2009 to 2011.

  4. High specific activity N-Acetyl-3H-α-Aspartyl- L-Glutamic at micro mole scale

    International Nuclear Information System (INIS)

    High specific activity N-Acetyl-3H- α -Aspartyl-I-Glutamic acid at micro mole scale in prepared acetylating L- α -Aspartyl-L-glutamic with 3H-acetic anhydride in re distilled toluene. The product le purified through cationic and anionic columns. The radiochemical purity as determined by thin-layer chromatography is greater then 99% at the time preparation. (Author) 5 refs

  5. Study of the regional CO2 mole fractions filtering approach at a WMO/GAW regional station in China

    Directory of Open Access Journals (Sweden)

    S. X. Fang

    2015-07-01

    Full Text Available The identification of atmospheric CO2 observation data which is minimally influenced by very local emissions/removals is essential for the estimation of trend analysis, regional sources and sinks, and for modeling of long-range transport of CO2. In this study, four approaches are used to filter the atmospheric CO2 observation records from 2009 to 2011 at one World Meteorological Organization/Global Atmosphere Watch (WMO/GAW regional station (Lin'an, LAN in China. The methods are based on the atmospheric black carbon concentration (BC, on a statistical approach (REBS, on CH4 as auxiliary tracer (AUX and on meteorological parameters (MET. All approaches do suitably well to capture the seasonal CO2 cycle at LAN. Differences are observed in the average regional mole fractions with annual values in the REBS method at least 1.7 ± 0.2 ppm higher than the other methods. The BC method may underestimate the regional CO2 mole fractions during winter-spring period and should be treated with caution. The REBS method is a purely statistical method and it may also introduce errors on the regional CO2 mole fractions evaluations, as the filtered trend may be deviated by the "noisy" raw data series. Although there are correlations between CH4 and CO2 mole fractions at LAN, the different source/sink regimes may introduce bias on the regional CO2 estimation in the AUX method, typically in summer. Overall, the MET method seems to be the most favorable because it mainly focuses on the influence of potential local sources and sinks and considers diurnal variations, local topography, and meteorological conditions. Using the MET method, the annual growth rate of regional CO2 at LAN is determined to be 3.1 ± 0.01 ppm yr−1 (standard error from 2009 to 2013.

  6. Pigmentary Markers in Danes – Associations with Quantitative Skin Colour, Nevi Count, Familial Atypical Multiple-Mole, and Melanoma Syndrome

    OpenAIRE

    Johansen, Peter; Andersen, Jeppe Dyrberg; Madsen, Linnea Nørgård; Ullum, Henrik; Glud, Martin; Børsting, Claus; Gniadecki, Robert; Morling, Niels

    2016-01-01

    To investigate whether pigmentation genes involved in the melanogenic pathway (melanogenesis) contributed to melanoma predisposition, we compared pigmentary genetics with quantitative skin pigmentation measurements, the number of atypical nevi, the total nevus count, and the familial atypical multiple mole and melanoma (FAMMM) syndrome. We typed 32 pigmentary SNP markers and sequenced MC1R in 246 healthy individuals and 116 individuals attending periodic control for malignant melanoma develop...

  7. Challenging the inbreeding hypothesis in a eusocial mammal: population genetics of the naked mole-rat, Heterocephalus glaber.

    Science.gov (United States)

    Ingram, Colleen M; Troendle, Nicholas J; Gill, Clare A; Braude, Stanton; Honeycutt, Rodney L

    2015-10-01

    The role of genetic relatedness in the evolution of eusociality has been the topic of much debate, especially when contrasting eusocial insects with vertebrates displaying reproductive altruism. The naked mole-rat, Heterocephalus glaber, was the first described eusocial mammal. Although this discovery was based on an ecological constraints model of eusocial evolution, early genetic studies reported high levels of relatedness in naked mole-rats, providing a compelling argument that low dispersal rates and consanguineous mating (inbreeding as a mating system) are the driving forces for the evolution of this eusocial species. One caveat to accepting this long-held view is that the original genetic studies were based on limited sampling from the species' geographic distribution. A growing body of evidence supports a contrary view, with the original samples not representative of the species-rather reflecting a single founder event, establishing a small population south of the Athi River. Our study is the first to address these competing hypotheses by examining patterns of molecular variation in colonies sampled from north and south of the Athi and Tana rivers, which based on our results, serve to isolate genetically distinct populations of naked mole-rats. Although colonies south of the Athi River share a single mtDNA haplotype and are fixed at most microsatellite loci, populations north of the Athi River are considerably more variable. Our findings support the position that the low variation observed in naked mole-rat populations south of the Athi River reflects a founder event, rather than a consequence of this species' unusual mating system. PMID:26407630

  8. CFD modelling of most probable bubble nucleation rate from binary mixture with estimation of components' mole fraction in critical cluster

    Science.gov (United States)

    Hong, Ban Zhen; Keong, Lau Kok; Shariff, Azmi Mohd

    2016-05-01

    The employment of different mathematical models to address specifically for the bubble nucleation rates of water vapour and dissolved air molecules is essential as the physics for them to form bubble nuclei is different. The available methods to calculate bubble nucleation rate in binary mixture such as density functional theory are complicated to be coupled along with computational fluid dynamics (CFD) approach. In addition, effect of dissolved gas concentration was neglected in most study for the prediction of bubble nucleation rates. The most probable bubble nucleation rate for the water vapour and dissolved air mixture in a 2D quasi-stable flow across a cavitating nozzle in current work was estimated via the statistical mean of all possible bubble nucleation rates of the mixture (different mole fractions of water vapour and dissolved air) and the corresponding number of molecules in critical cluster. Theoretically, the bubble nucleation rate is greatly dependent on components' mole fraction in a critical cluster. Hence, the dissolved gas concentration effect was included in current work. Besides, the possible bubble nucleation rates were predicted based on the calculated number of molecules required to form a critical cluster. The estimation of components' mole fraction in critical cluster for water vapour and dissolved air mixture was obtained by coupling the enhanced classical nucleation theory and CFD approach. In addition, the distribution of bubble nuclei of water vapour and dissolved air mixture could be predicted via the utilisation of population balance model.

  9. Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea).

    Science.gov (United States)

    Gu, Se Hun; Kumar, Mukesh; Sikorska, Beata; Hejduk, Janusz; Markowski, Janusz; Markowski, Marcin; Liberski, Paweł P; Yanagihara, Richard

    2016-01-01

    Genetically distinct hantaviruses have been identified in five species of fossorial moles (order Eulipotyphla, family Talpidae) from Eurasia and North America. Here, we report the isolation and partial characterization of a highly divergent hantavirus, named Nova virus (NVAV), from lung tissue of a European mole (Talpa europaea), captured in central Poland in August 2013. Typical hantavirus-like particles, measuring 80-120 nm in diameter, were found in NVAV-infected Vero E6 cells by transmission electron microscopy. Whole-genome sequences of the isolate, designated NVAV strain Te34, were identical to that amplified from the original lung tissue, and phylogenetic analysis of the full-length L, M and S segments, using maximum-likelihood and Bayesian methods, showed that NVAV was most closely related to hantaviruses harbored by insectivorous bats, consistent with an ancient evolutionary origin. Infant Swiss Webster mice, inoculated with NVAV by the intraperitoneal route, developed weight loss and hyperactivity, beginning at 16 days, followed by hind-limb paralysis and death. High NVAV RNA copies were detected in lung, liver, kidney, spleen and brain by quantitative real-time RT-PCR. Neuropathological examination showed astrocytic and microglial activation and neuronal loss. The first mole-borne hantavirus isolate will facilitate long-overdue studies on its infectivity and pathogenic potential in humans. PMID:26892544

  10. A bilogarithmic method for the spectrophotometric evaluation of stability constants of 1:1 weak complexes from mole ratio data.

    Science.gov (United States)

    Boccio, Maravillas; Sayago, Ana; Asuero, Agustín G

    2006-08-01

    The absorbance changes that occur when the mole ratio of the components of ligand complex equilibria is varied while the concentration of one component is kept constant (mole ratio method) allow evaluating stability constants in favourable conditions. Values of the corresponding stability (association) constants are normally assigned on the basis of spectrophotometric analysis. Determination of stability constants can be performed by a number of linear procedures, but most of these, suffer from theoretical and practical drawbacks, e.g., linear transformation of the rectangular hyperbola type of binding constants, is valid only when one of the two species is present in a large excess. A rigorous treatment of the experimental mole ratio data for 1:1 weak complexes is carried out in this paper with the aim of eliminating some of the assumptions involved in the other methods usually applied for evaluating stability constants. Orthogonal regression is required in order to take into account the error in both axes. The method has been applied to literature data for the iron(III)-thiocyanate and nickel(II)-selenocyanate systems, as well as to a number of host-guest cyclodextrin complexes. PMID:16647826

  11. Invasive Complete Hydatidiform Moles: Analysis of a Case Series With Genotyping.

    Science.gov (United States)

    Bynum, Jennifer; Murphy, Kathleen M; DeScipio, Cheryl; Beierl, Katie; Adams, Emily; Anderson, Derek; Vang, Russell; Ronnett, Brigitte M

    2016-03-01

    Complete hydatidiform moles (CHM) are purely androgenetic conceptions, with most (∼85%) arising from fertilization of an egg lacking maternal DNA by a single sperm that duplicates (homozygous/monospermic 46,XX) and a small subset arising via fertilization by 2 sperms (heterozygous/dispermic 46,XY or 46,XX). It remains controversial if heterozygous/dispermic CHMs have a significantly greater risk of persistent gestational trophoblastic disease. Analysis of zygosity of CHMs with and without invasion at presentation, including invasive CHMs with concurrent atypical trophoblastic proliferations concerning for or consistent with choriocarcinoma, has not been specifically addressed. In a prospective series of 1024 products of conception specimens subjected to immunohistochemical analysis of p57 expression and molecular genotyping with short tandem-repeat markers, 288 CHMs were diagnosed, of which 126 were genotyped, including 16 invasive CHMs. Zygosity was compared between those with and without invasion. Of the 16 study cases, 12 (75%) were homozygous/monospermic XX and 4 (25%) were heterozygous/dispermic (3 XY and 1 XX). Of the 110 genotyped noninvasive CHMs, 96 (87%) were homozygous/monospermic XX and 14 (13%) were heterozygous/dispermic (12 XY, 2 XX). Comparison of the zygosity results for the invasive CHMs (study group) with the noninvasive CHMs in the database did not demonstrate a statistically significant difference (P=0.24, Fisher exact test). In addition, of the 3 cases associated with metastatic gestational trophoblastic disease (pulmonary nodules) at presentation, 2 were homozygous/monospermic XX, indicating that this form is not without risk of significant gestational trophoblastic disease. Thus, the current study has demonstrated a higher frequency of heterozygous/dispermic CHMs among invasive cases compared with those lacking invasion, but does not support the use of zygosity data for risk assessment of CHMs. A persistent, unresolved diagnostic challenge

  12. AO distal radius volar plate fixation for AO type C distal radius fracture

    International Nuclear Information System (INIS)

    We applied a volar AO distal radius plate for AO type C fractures of the distal radius. The subjects included 1 man and 12 women, and their mean age at the time of surgery was 62 years. The mean follow-up period was 10 months. According to the AO classification, 3 cases were C2, 7 cases were C3-1, and 3 cases were C3-2. Union was achieved in all cases. Wrist function was evaluated using the modified Mayo wrist scoring system. The functional results were excellent in 7 cases, good in 4 cases, and fair in 2 cases. To evaluate the strength of the initial fixation and the accuracy of joint surface reduction after surgery, palmar tilt, ulnar variance, and radial inclination were measured from radiographs that were taken before surgery, immediately after surgery, and at the final follow-up examination, and from CT scan images taken at the final follow-up examination. In 3 cases, correction losses included poor initial fixation and joint surface reduction, and all 3 were AO C3-2 fractures. These cases had comminuted fragments, both volar and dorsal metaphysic, and lunate fossa fragments. A volar locking plate fixation that can support the articular surface should be applied to AO C2 and C3-1 fractures. However, in the absence of bone grafting, it should not be applied to AO C3-2 fractures because it is very difficult not only to reduce the concave lunate fossa fragments but also to fix the fragments to the volar metaphysis. (author)

  13. AO Observations of Three Powerful Radio Galaxies

    Energy Technology Data Exchange (ETDEWEB)

    de Vries, W; van Bruegel, W; Quirrenbach, A

    2002-08-01

    The host galaxies of powerful radio sources are ideal laboratories to study active galactic nuclei (AGN). The galaxies themselves are among the most massive systems in the universe, and are believed to harbor supermassive black holes (SMBH). If large galaxies are formed in a hierarchical way by multiple merger events, radio galaxies at low redshift represent the end-products of this process. However, it is not clear why some of these massive ellipticals have associated radio emission, while others do not. Both are thought to contain SMBHs, with masses proportional to the total luminous mass in the bulge. It either implies every SMBH has recurrent radio-loud phases, and the radio-quiet galaxies happen to be in the ''low'' state, or that the radio galaxy nuclei are physically different from radio-quiet ones, i.e. by having a more massive SMBH for a given bulge mass. Here we present the first results from our adaptive optics imaging and spectroscopy pilot program on three nearby powerful radio galaxies. Initiating a larger, more systematic AO survey of radio galaxies (preferentially with Laser Guide Star equipped AO systems) has the potential of furthering our understanding of the physical properties of radio sources, their triggering, and their subsequent evolution.

  14. The effects of oxotremorine, epibatidine, atropine, mecamylamine and naloxone in the tail-flick, hot-plate, and formalin tests in the naked mole-rat (Heterocephalus glaber)

    DEFF Research Database (Denmark)

    Dulu, Thomas D; Kanui, Titus I; Towett, Philemon K;

    2014-01-01

    The naked mole-rat (Heterocephalus glaber) is a promising animal model for the study of pain mechanisms, therefore a thorough characterization of this species is essential. The aim of the present study was to establish the naked mole-rat as a model for studying the cholinergic receptor system in ...... antinociceptive effects of cholinergic agonists, it is suggested that the cholinergic antinociception acts via a gateway facilitated by opioid receptor blockage; however, the precise interaction between these receptor systems needs further investigation....

  15. Effects of Laboratory Housing on Exploratory Behaviour, Novelty Discrimination and Spatial Reference Memory in a Subterranean, Solitary Rodent, the Cape Mole-Rat (Georychus capensis)

    OpenAIRE

    Oosthuizen, Maria Kathleen; Scheibler, Anne-Gita; Charles Bennett, Nigel; Amrein, Irmgard

    2013-01-01

    A large number of laboratory and field based studies are being carried out on mole-rats, both in our research group and others. Several studies have highlighted the development of adverse behaviours in laboratory animals and have emphasised the importance of enrichment for captive animals. Hence we were interested in evaluating how laboratory housing would affect behavioural performance in mole-rats. We investigated exploratory behaviour, the ability to discriminate between novel and familiar...

  16. Effects of laboratory housing on exploratory behaviour, novelty discrimination and spatial reference memory in a subterranean, solitary rodent, the Cape mole-rat (Georychus capensis)

    OpenAIRE

    Oosthuizen, Maria Kathleen; Scheibler, Anne-Gita; Bennett, Nigel Charles; Amrein, Irmgard

    2013-01-01

    A large number of laboratory and field based studies are being carried out on mole-rats, both in our research group and others. Several studies have highlighted the development of adverse behaviours in laboratory animals and have emphasised the importance of enrichment for captive animals. Hence we were interested in evaluating how laboratory housing would affect behavioural performance in mole-rats. We investigated exploratory behaviour, the ability to discriminate between novel and familiar...

  17. Effect of the Ti/B4C mole ratio on the reaction products and reaction mechanism in an Al–Ti–B4C powder mixture

    International Nuclear Information System (INIS)

    The effect of the Ti/B4C mole ratio on the fabrication behavior of Al composites is investigated using Al–Ti–B4C powder mixtures as reactants. The quick spontaneous infiltration (QSI) process combined with the combustion reaction and DTA analysis were used. According to the thermodynamic predictions, which are verified in the experimental results, TiB2 is formed in all the samples whereas TiC is only formed in reactants with a Ti/B4C mole ratio of more than two. The C atoms from the reacted B4C do not move into TiC but instead they move into Al3BC or Al4C3 when the Ti/B4C mole ratio is less than two. In addition, the reaction mechanism with a Ti/B4C mole ratio of 0.75 is investigated extensively. - Highlights: • The critical role of the Ti/B4C mole ratio on the reaction products of Al–Ti–B4C was studied using experiments. • The experimental results are also supported by thermodynamic calculations presented in this paper. • The reaction mechanism with a Ti/B4C mole ratio of 0.75 is investigated extensively

  18. Impact of indium mole fraction on the quantum transport of ultra-scaled In x Ga1- x As double-gate Schottky MOSFET: tight-binding approach

    Science.gov (United States)

    Ahangari, Zahra

    2016-02-01

    This paper explores the impact of indium mole fraction on the electrical characteristic of In x Ga1- x As double-gate Schottky MOSFET (SBFET) in nanoscale regime. A 20-band sp 3 d 5 s * tight-binding formalism is applied to compute the bandstructure of ultra-thin body structure as a function of indium mole fraction. The injection velocity of carriers is increased as the indium mole fraction approaches to x = 1. Quantum confinement results in an increment of the effective Schottky barrier height especially for the increased values of indium mole fraction. The ultra-scaled In x Ga1- x As SBFET suffers from a low conduction band DOS in the Γ valley that results in serious degradation of the gate capacitance. The electrical characteristic of this device is considered by solving self-consistent 2D Schrődinger-Poisson equations based on non-equilibrium Green's function formalism. For channel thicknesses where the effect of quantum confinement on the gate capacitance is not dominant, shrinking the channel thickness besides increasing the indium mole fraction improves the electrical characteristic of the device. However, for the ultra-scaled structure, the indium mole fraction enhancement degrades the device performance due to the enhanced value of Schottky barrier height and low DOS.

  19. Environmental physiology of the mole crab Emerita asiatica, at a power plant discharge area on the east coast of India

    International Nuclear Information System (INIS)

    Cage experiments at the discharge area of Madras Atomic Power Station (MAPS) facilitated studies of thermal tolerance in Emerita asiatica. At the laboratory, oxygen consumption at various temperatures and varying salinities was also investigated. In the field 100% mortality of crabs was recorded at the Condenser Cooling Water Pumps (CCWP) discharge site compared to no mortality at the Processed Sea Water Pumps (PSWP) site. This observation implicated temperature as a stress factor at the CCWP outfall, because other factors, including residual chlorine and water velocity, were the same at the PSWP and CCWP sites. Laboratory experiments on tolerance revealed that 38.5oC was lethal to mole crabs. The time taken for 100% mortality decreased as the temperature increased from 35 to 40oC. Oxygen metabolism showed a progressive increase with temperature from 29 to 36oc, and declined at 37oC. The influence of salinity on oxygen consumption was marginal at salinities of 20 to 35o/oo but, when reduced to 15o/oo, the oxygen consumption declined. The present study thus indicates that temperature could be the lethal factor, determining the distribution of mole crabs near the power station, where water temperature can exceed 40oC. (author)

  20. Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: Utility and potential for the discovery of novel evolutionary patterns

    KAUST Repository

    Malik, Assaf

    2011-08-12

    The blind subterranean mole rat (Spalax ehrenbergi superspecies) is a model animal for survival under extreme environments due to its ability to live in underground habitats under severe hypoxic stress and darkness. Here we report the transcriptome sequencing of Spalax galili, a chromosomal type of S. ehrenbergi. cDNA pools from muscle and brain tissues isolated from animals exposed to hypoxic and normoxic conditions were sequenced using Sanger, GS FLX, and GS FLX Titanium technologies. Assembly of the sequences yielded over 51,000 isotigs with homology to ~12,000 mouse, rat or human genes. Based on these results, it was possible to detect large numbers of splice variants, SNPs, and novel transcribed regions. In addition, multiple differential expression patterns were detected between tissues and treatments. The results presented here will serve as a valuable resource for future studies aimed at identifying genes and gene regions evolved during the adaptive radiation associated with underground life of the blind mole rat. 2011 Malik et al.

  1. Development of traceable precision dynamic dilution method to generate dimethyl sulphide gas mixtures at sub-nanomole per mole levels for ambient measurement.

    Science.gov (United States)

    Kim, Mi Eon; Kim, Yong Doo; Kang, Ji Hwan; Heo, Gwi Suk; Lee, Dong Soo; Lee, Sangil

    2016-04-01

    Dimethyl sulphide (DMS) is an important compound in global atmospheric chemistry and climate change. Traceable international standards are essential for measuring accurately the long-term global trend in ambient DMS. However, developing accurate gas standards for sub-nanomole per mole (nmol/mol) mole fractions of DMS in a cylinder is challenging, because DMS is reactive and unstable. In this study, a dynamic dilution method that is traceable and precise was developed to generate sub-nmol/mol DMS gas mixtures with a dynamic dilution system based on sonic nozzles and a long-term (>5 years) stable 10 μmol/mol parent DMS primary standard gas mixtures (PSMs). The dynamic dilution system was calibrated with traceable methane PSMs, and its estimated dilution factors were used to calculate the mole fractions of the dynamically generated DMS gas mixtures. A dynamically generated DMS gas mixture and a 6 nmol/mol DMS PSM were analysed against each other by gas chromatography with flame-ionisation detection (GC/FID) to evaluate the dilution system. The mole fractions of the dynamically generated DMS gas mixture determined against a DMS PSM and calculated with the dilution factor agreed within 1% at 6 nmol/mol. In addition, the dynamically generated DMS gas mixtures at various mole fractions between 0.4 and 11.7 nmol/mol were analysed by GC/FID and evaluated for their linearity. The analytically determined mole fractions showed good linearity with the mole fractions calculated with the dilution factors. Results showed that the dynamic dilution method generates DMS gas mixtures ranging between 0.4 nmol/mol and 12 nmol/mol with relative expanded uncertainties of less than 2%. Therefore, the newly developed dynamic dilution method is a promising reference method for generating sub-nmol/mol DMS gas standards for accurate ambient measurements. PMID:26838438

  2. Adesao ao guia alimentar para populacao brasileira

    Directory of Open Access Journals (Sweden)

    Eliseu Verly Junior

    2013-12-01

    Full Text Available OBJETIVO : Analisar a adesão ao Guia Alimentar para População Brasileira. MÉTODOS : Amostra composta por participantes do Inquérito de Saúde de São Paulo (n = 1.661 que preencheram dois recordatórios de 24 horas. Foi utilizado modelo bivariado de efeito misto para a razão entre o consumo de energia do grupo de alimentos e o consumo calórico total. A razão estimada foi utilizada para calcular o percentual de indivíduos com consumo abaixo ou acima da recomendação. RESULTADOS : Pelo menos 80,0% da população consome abaixo do recomendado para: leite e derivados; frutas e sucos de frutas; e cereais, tubérculos e raízes; aproximadamente 60,0% para legumes e verduras; 30,0% para feijões; e 8,0% para carnes e ovos. Adolescentes apresentaram a maior inadequação para legumes e verduras (90,0%, e o estrato de maior renda foi associado à menor inadequação para óleos, gorduras e sementes oleaginosas (57,0%. CONCLUSÕES : Foi observado consumo inadequado dos grupos de alimentos relacionados com aumento do risco de doenças crônicas.

  3. Low-order AO system in LAMOST

    Science.gov (United States)

    Yuan, Xiangyan; Cui, Xiangqun; Liu, Genrong; Zhang, Yong; Qi, Yongjun

    2006-06-01

    The large sky area multi-object fiber spectroscopic telescope (LAMOST) is a special reflecting Schmidt telescope with its main optical axis on the meridian plane tilted by an angle of 25° to the horizontal. The clear aperture is 4m, working in optical band. The light path is 60m long when working in observing mode and it will be doubled if work in auto-collimation mode. So the image quality is affected clearly by the ground seeing and the dome seeing. In order to improve the seeing condition of the long light path, we enclosed the spherical primary and the focus unit in a tunnel enclosure and cooled the tunnel. This is an effective but passive method. Corresponding experiments and simulations show the main part of the aberrations caused by the ground seeing and dome seeing is slowly changed low order items such as tip-tilt, defocus, astigmatism, coma and spherical aberration. Thus we plan to develop the low-order AO system based on the low-cost 37-channel OKO deformable mirror for the telescope to better the ground seeing and the dome seeing, not aimed to reach diffraction limited image. This work is being carried on now.

  4. Acute onset of severe hemolysis, elevated liver enzymes, and low platelet count syndrome in a patient with a partial hydatidiform mole at 17 weeks gestation.

    Science.gov (United States)

    Sherer, David M; Dalloul, Mudar; Stimphil, Raphael; Hellmann, Mira; Khoury-Collado, Fady; Osho, Joseph; Fomitcheva, Larissa; Brennan, Kelly J; Abulafia, Ovadia

    2006-04-01

    Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 x 10 (9) cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole. PMID:16586230

  5. Sensibilidade de estirpes de Bradyrhizobium ao glyphosate

    Directory of Open Access Journals (Sweden)

    Rodrigo Josemar Seminoti Jacques

    2010-02-01

    Full Text Available A aplicação do glyphosate sobre a soja resistente a este herbicida pode causar prejuízos à simbiose com o rizóbio. O objetivo deste trabalho foi avaliar a sensibilidade ao herbicida glyphosate de três estirpes de Bradyrhizobium recomendadas para a produção de inoculantes de sementes de soja no Brasil. Avaliou-se o efeito das concentrações de 0,0; 5,4; 10,8; 21,6 e 43,2 µg L-1 do ingrediente ativo do glyphosate [N-(fosfonometil glicina] no meio YM líquido sobre o crescimento de B. japonicum (estirpe SEMIA 5079 e de B. elkanii (estirpe SEMIA 5019 e estirpe SEMIA 587, por meio de leituras das densidades óticas e geração de curvas de crescimento. As reduções de crescimento na presença da menor concentração do glyphosate foram de 18% para SEMIA 5079, 29% para SEMIA 5019 e de 35% para SEMIA 587, sendo, de modo geral, quanto maior a concentração do herbicida no meio de cultura maior a inibição do crescimen­to. As estirpes apresentaram sensibilidade diferencial somente às concentrações mais baixas do glyphosate; nesse caso, foi possível determinar a seguinte ordem de sensibilidade: SEMIA 587 > SEMIA 5019 > SEMIA 5079. Essa sensibilidade diferencial é dependente da concentração do herbicida, pois na presença de 43,2 µg L-1 todas as estirpes tiveram seu crescimento severamente reduzido, não havendo diferença entre elas.

  6. 30Si Mole Fraction of a Silicon Material Highly Enriched in 28Si Determined by Instrumental Neutron Activation Analysis

    CERN Document Server

    D'Agostino, Giancarlo; Mana, Giovanni; Oddone, Massimo; Pramann, Axel; Prata, Michele

    2016-01-01

    The latest determination of the Avogadro constant, carried out by counting the atoms in a pure silicon crystal highly enriched in 28Si, reached the target 2x10-8 relative uncertainty required for the redefinition of the kilogram based on the Planck constant. The knowledge of the isotopic composition of the enriched silicon material is central; it is measured by isotope dilution mass spectrometry. In this work, an independent estimate of the 30Si mole fraction was obtained by applying a relative measurement protocol based on Instrumental Neutron Activation Analysis. The amount of 30Si isotope was determined by counting the 1266.1 keV gamma-photons emitted during the radioactive decay of the radioisotope 31Si produced via the neutron capture reaction 30Si(n,gamma)31Si. The x(30Si) = 1.043(19)x10-6 mol mol-1 is consistent with the value currently adopted by the International Avogadro Coordination.

  7. Comment on a mathematical model for estimating biological damage caused by radiation. Whack-A-Mole model

    International Nuclear Information System (INIS)

    We propose a mathematical model, Whack-A-Mole (WAM) model which can estimate the biological effect caused by radiation. The WAM model assumes that the basic element is a cell and the number of cells increases or decreases due to response to stimulus, damage and recovery, cause by radiation and so on. WAM takes into account dose rate as an important physical quantity, which marks a fundamental difference from target theory or LQ model. WAM model reproduces various experimental data of mutation frequency induced by radiation, for example, mega-mouse project. Furthermore, we can predict unknown experimental results. From WAM model, it is learnt that the mutation frequency caused by radiation is not proportional to dose but also have saturation value. There is some possibility that the WAM model will drastically change risk estimation of radiation as it brings us different results from those of target theory or LQ model. (author)

  8. Spatial and temporal activity patterns of the free-living giant mole-rat (Fukomys mechowii, the largest social bathyergid.

    Directory of Open Access Journals (Sweden)

    Matěj Lövy

    Full Text Available Despite the considerable attention devoted to the biology of social species of African mole-rats (Bathyergidae, Rodentia, knowledge is lacking about their behaviour under natural conditions. We studied activity of the largest social bathyergid, the giant mole-rat Fukomys mechowii, in its natural habitat in Zambia using radio-telemetry. We radio-tracked six individuals during three continuous 72-h sessions. Five of these individuals, including a breeding male, belonged to a single family group; the remaining female was probably a solitary disperser. The non-breeders of the family were active (i.e. outside the nest 5.8 hours per 24h-day with the activity split into 6.5 short bouts. The activity was more concentrated in the night hours, when the animals also travelled longer distances from the nest. The breeding male spent only 3.2 hours per day outside the nest, utilizing less than 20% of the whole family home range. The dispersing female displayed a much different activity pattern than the family members. Her 8.0 hours of outside-nest activity per day were split into 4.6 bouts which were twice as long as in the family non-breeders. Her activity peak in the late afternoon coincided with the temperature maximum in the depth of 10 cm (roughly the depth of the foraging tunnels. Our results suggest that the breeding individuals (at least males contribute very little to the work of the family group. Nevertheless, the amount of an individual's activity and its daily pattern are probably flexible in this species and can be modified in response to actual environmental and social conditions.

  9. Reactive scattering of halogen molecules. [Angular and velocity distributions, stabilities 6. 8 to 17. 7 kcal/mole, FORTRAN

    Energy Technology Data Exchange (ETDEWEB)

    Valentini, J.J.

    1976-11-01

    A study of the endoergic, bimolecular reactions of F/sub 2/ with I/sub 2/, ICl, and HI in a crossed molecular beam experiment is described. The trihalogens IIF, ClIF, and HIF were directly observed as the products of these reactions. At high collision energies a second reactive channel producing IF becomes important. Product angular and velocity distributions show that this IF does not result from a four-center exchange reaction. Measured threshold energies for the formation of IIF, ClIF, and HIF yield lower bounds to the stabilities of these molecules, with respect to the separated atoms, of 69, 81, and 96 kcal/mole, respectively. Analysis of product center-of-mass angular distributions indicates that a slightly nonlinear approach is most effective in bringing about reaction to form the stable triatomic radical. Also described is a crossed molecular beam study of the Cl + Br/sub 2/ ..-->.. BrCl + Br reaction at collision energies from 6.8 to 17.7 kcal/mole. The results indicate that this reaction has the characteristics of an exoergic reaction on an attractive potential energy surface with early energy release. Reagent translational energy is very efficiently channeled into product internal energy. At high collision energy the reaction appears to approach the spectator stripping limit. Finally, a series of computer programs which can be used to carry out the requisite data analysis for crossed molecular beam reactive scattering experiments are described. These programs recover the reactive scattering center-of-mass flux distribution from the measured angular and velocity distributions of the products.

  10. Immunohistochemical Analysis of E-Cadherin, p53 and Inhibin-α Expression in Hydatidiform Mole and Hydropic Abortion.

    Science.gov (United States)

    Erol, Onur; Süren, Dinç; Tutuş, Birsel; Toptaş, Tayfun; Gökay, Ahmet Arda; Derbent, Aysel Uysal; Özel, Mustafa Kemal; Sezer, Cem

    2016-07-01

    The purpose of this study was to investigate the role of E-cadherin, p53, and inhibin-α immunostaining in the differential diagnosis of hydropic abortion (HA), partial hydatidiform mole (PHM), and complete hydatidiform mole (CHM). E-cadherin, p53, and inhibin-α protein expression patterns were investigated immunohistochemically using paraffin -embedded tissue sections from histologically diagnosed cases of HA (n = 23), PHM (n = 24), and CHM (n = 23). Expression patterns of these markers were scored semi-quantitatively according to the staining intensity, percentage of positive cells, and immunoreactivity score. Classification of cases was established on histologic criteria and supported by the molecular genotyping. Immunostaining allowed the identification of specific cell types with E-cadherin, p53, and inhibin-α expression in all cases. E-cadherin expression was detected on the cell surface of villous cytotrophoblasts. We observed a marked decline in the expression of E-cadherin from HAs to PHMs to CHMs. The p53-positive reaction was restricted to the nucleus of villous cytotrophoblasts. Significantly increased p53 expression was observed in CHMs, compared with HAs and PHMs. The expression of inhibin-α was localised in the cytoplasm of villous syncytiotrophoblasts, and the expression of this marker was significantly higher in PHMs and CHMs than HAs. In conclusion, immunohistochemical analysis of E-cadherin, p53, and inhibin-α expression could serve as a useful adjunct to conventional methods in the differential diagnosis of HA, PHM, and CHM. PMID:26683836

  11. The Mars Underground Mole (MUM): A Subsurface Penetration Device with Infrared Reflectance and Raman Spectroscopic Sensing Capability

    Science.gov (United States)

    Stoker, C. R.; Richter, L.; Smith, W. H.; Lemke, L. G.; Hammer, P.; Dalton, J. B.; Glass, B.; Zent, A.

    2003-01-01

    Searching for evidence of life on Mars will probably require access to the subsurface. The Martian surface is bathed in ultraviolet radiation which decomposes organic compounds, destroying possible evidence for life. Also, experiments performed by the Viking Landers imply the presence of several strongly oxidizing compounds at the Martian surface that may also play a role in destroying organic compounds near the surface. While liquid water is unstable on the Martian surface, and ice is unstable at the surface at low latitudes, recent results from the Mars Odyssey Gamma Ray Spectrometer experiment indicate that water ice is widely distributed near the surface under a thin cover of dry soil. Organic compounds created by an ancient Martian biosphere might be preserved in such ice-rich layers. Furthermore, accessing the subsurface provides a way to identify unique stratigraphy such as small-scale layering associated with lacustrine sediments. Subsurface access might also provide new insights into the Mars climate record that may be preserved in the Polar Layered Deposits. Recognizing the importance of accessing the subsurface of Mars to the future scientific exploration of the planet, the Mars Surveyor 2007 Science Definition Team called for drilling beneath the surface soils. Subsurface measurements are also cited as high priority in by MEPAG. Recognizing the importance of accessing the Martian subsurface to search for life, the European Space Agency has incorporated a small automated burrowing device called a subsurface penetrometer or Mole onto the Beagle 2 lander planned for 2003 launch. This device, called the Planetary Underground Tool (PLUTO), is a pointed slender cylinder 2 cm wide and 28 cm long equipped with a small sampling device at the pointed end that collects samples and brings them to the surface for analysis. Drawing on the PLUTO design, we are developing a larger Mole carrying sensors for identifying mineralogy, organic compounds, and water.

  12. Subcaste differences in neural activation suggest a prosocial role for oxytocin in eusocial naked mole-rats.

    Science.gov (United States)

    Hathaway, Georgia A; Faykoo-Martinez, Mariela; Peragine, Deane E; Mooney, Skyler J; Holmes, Melissa M

    2016-03-01

    The neuropeptide oxytocin (OT) influences prosocial behavior(s), aggression, and stress responsiveness, and these diverse effects are regulated in a species- and context-specific manner. The naked mole-rat (Heterocephalus glaber) is a unique species with which to study context-dependent effects of OT, exhibiting a strict social hierarchy with behavioral specialization within the subordinate caste: soldiers are aggressive and defend colonies against unfamiliar conspecifics while workers are prosocial and contribute to in-colony behaviors such as pup care. To determine if OT is involved in subcaste-specific behaviors, we compared behavioral responses between workers and soldiers of both sexes during a modified resident/intruder paradigm, and quantified activation of OT neurons in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON) using the immediate-early-gene marker c-fos co-localized with OT neurons. Resident workers and soldiers were age-matched with unfamiliar worker stimulus animals as intruders, and encounters were videorecorded and scored for aggressive behaviors. Colony-matched controls were left in their home colony for the duration of the encounters. Brains were extracted and cell counts were conducted for OT immunoreactive (ir), c-fos-ir, and percentage of OT-c-fos double-labeled cells. Results indicate that resident workers were less aggressive but showed greater OT neural activity than soldiers. Furthermore, a linear model including social treatment, cortisol, and subcaste revealed that subcaste was the only significant predictor of OT-c-fos double-labeled cells in the PVN. These data suggest that in naked mole-rats OT promotes prosocial behaviors rather than aggression and that even within subordinates status exerts robust effects on brain and behavior. PMID:26718226

  13. Response of mole crab, Emerita emeritus to the thermal effluents from the Madras Atomic Power Station at Kalpakkam

    International Nuclear Information System (INIS)

    Mole crabs belonging to the genus Emerita are exclusively inhabitants of exposed wave washed sandy beaches in certain temperate and tropical seas. Its sedentary adult life and a primitive filter-feeding behavior make this intertidal crab an excellent indicator species for monitoring anthropogenic impact. Hence, this sand crab has been used to determine the effect of elevated temperature (rT) arising out of the thermal effluent from the Madras Atomic Power Station (MAPS), Kalpakkam with special reference to the intertidal fauna. Since Emerita exhibits limited capacity to move from their place of habitation, an analysis of the population structure of Emerita emeritus in the Kalpakkam coast including the impacted and the adjoining control sandy beaches on either side of the mixing point in the vicinity of the power plant was done. The data indicate that in the impact zone having an elevated seawater temperature of <35 deg C, the crab is completely absent. However, as we move away from the impact zone, with normalization of seawater temperature, Emerita move to safer areas on either side of the impact zone. Thus, the extensive field data on the distribution of mole crabs indicated that population structure is affected by the thermal plume, although the shifting positions of the mixing point (caused by northerly and southerly long shore currents) allowed decolonization of Emerita due to transmigration in positions that were earlier mixing points. This paper also describes a complete larval development of Emerita emeritus in the laboratory. Different life stages of E. emeritus were subjected to various power plant stressors to determine their varying responses. The expression of heat shock protein (hsp) in the gill tissue of the adult crabs was also observed when the crabs were exposed to elevated temperatures (35 deg C). However, no expression of heat shock proteins was observed when the crabs were subjected to chlorine stress. (author)

  14. Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat.

    Science.gov (United States)

    Triplett, Judy C; Swomley, Aaron; Kirk, Jessime; Lewis, Katilyn; Orr, Miranda; Rodriguez, Karl; Cai, Jian; Klein, Jon B; Buffenstein, Rochelle; Butterfield, D Allan

    2015-08-01

    Naked mole-rats (NMRs) are the oldest-living rodent species. Living underground in a thermally stable ecological niche, NMRs have evolved certain exceptional traits, resulting in sustained health spans, negligible cognitive decline, and a pronounced resistance to age-related disease. Uncovering insights into mechanisms underlying these extraordinary traits involved in successful aging may conceivably provide crucial clues to extend the human life span and health span. One of the most fundamental processes inside the cell is the production of ATP, which is an essential fuel in driving all other energy-requiring cellular activities. Not surprisingly, a prominent hallmark in age-related diseases, such as neurodegeneration and cancer, is the impairment and dysregulation of metabolic pathways. Using a two-dimensional polyacrylamide gel electrophoresis proteomics approach, alterations in expression and phosphorylation levels of metabolic proteins in the brains of NMRs, aged 2-24 years, were evaluated in an age-dependent manner. We identified 13 proteins with altered levels and/or phosphorylation states that play key roles in various metabolic pathways including glycolysis, β-oxidation, the malate-aspartate shuttle, the Tricarboxylic Acid Cycle (TCA) cycle, the electron transport chain, NADPH production, as well as the production of glutamate. New insights into potential pathways involved in metabolic aspects of successful aging have been obtained by the identification of key proteins through which the NMR brain responds and adapts to the aging process and how the NMR brain adapted to resist age-related degeneration. This study examines the changes in the proteome and phosphoproteome in the brain of the naked mole-rat aged 2-24 years. We identified 13 proteins (labeled in red) with altered expression and/or phosphorylation levels that are conceivably associated with sustained metabolic functions in the oldest NMRs that may promote a sustained health span and life span

  15. First closed-loop visible AO test results for the advanced adaptive secondary AO system for the Magellan Telescope: MagAO's performance and status

    Science.gov (United States)

    Close, Laird M.; Males, Jared R.; Kopon, Derek A.; Gasho, Victor; Follette, Katherine B.; Hinz, Phil; Morzinski, Katie; Uomoto, Alan; Hare, Tyson; Riccardi, Armando; Esposito, Simone; Puglisi, Alfio; Pinna, Enrico; Busoni, Lorenzo; Arcidiacono, Carmelo; Xompero, Marco; Briguglio, Runa; Quiros-Pacheco, Fernando; Argomedo, Javier

    2012-07-01

    The heart of the 6.5 Magellan AO system (MagAO) is a 585 actuator adaptive secondary mirror (ASM) with response times (0.7 ms typically). This adaptive secondary will allow low emissivity and high-contrast AO science. We fabricated a high order (561 mode) pyramid wavefront sensor (similar to that now successfully used at the Large Binocular Telescope). The relatively high actuator count (and small projected ~23 cm pitch) allows moderate Strehls to be obtained by MagAO in the “visible” (0.63-1.05 μm). To take advantage of this we have fabricated an AO CCD science camera called "VisAO". Complete “end-to-end” closed-loop lab tests of MagAO achieve a solid, broad-band, 37% Strehl (122 nm rms) at 0.76 μm (i’) with the VisAO camera in 0.8” simulated seeing (13 cm ro at V) with fast 33 mph winds and a 40 m Lo locked on R=8 mag artificial star. These relatively high visible wavelength Strehls are enabled by our powerful combination of a next generation ASM and a Pyramid WFS with 400 controlled modes and 1000 Hz sample speeds (similar to that used successfully on-sky at the LBT). Currently only the VisAO science camera is used for lab testing of MagAO, but this high level of measured performance (122 nm rms) promises even higher Strehls with our IR science cameras. On bright (R=8 mag) stars we should achieve very high Strehls (>70% at H) in the IR with the existing MagAO Clio2 (λ=1-5.3 μm) science camera/coronagraph or even higher (~98% Strehl) the Mid-IR (8-26 microns) with the existing BLINC/MIRAC4 science camera in the future. To eliminate non-common path vibrations, dispersions, and optical errors the VisAO science camera is fed by a common path advanced triplet ADC and is piggy-backed on the Pyramid WFS optical board itself. Also a high-speed shutter can be used to block periods of poor correction. The entire system passed CDR in June 2009, and we finished the closed-loop system level testing phase in December 2011. Final system acceptance (

  16. From Performance Optimization to Simulation-based Forensic Engineering - An extensive Approach for Dynamic Modeling of the HP³-Mole for InSight

    OpenAIRE

    Lichtenheldt, Roy

    2015-01-01

    In order to enable the InSight’s investigations of the Martian interior, the HP³-Mole has to hammer itself deeper below the surface of the red planet, than any other instrument before. In order to achieve this challenging goal, the dynamics of the impact driven locomotion as well as the mutual influence between the stroke cycle and the regolith need to be well understood. However it is not possible to observe the complex mechanism behaviour while the HP³-Mole is operating in Martian soil or t...

  17. Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber)

    DEFF Research Database (Denmark)

    Jørgensen, Kristine B.; Krogh-Jensen, Karen; Pickering, Darryl S;

    2016-01-01

    musculus) using basic local alignment search tool (BLAST). The presence and function of M1 and M4 was investigated in vivo, using the formalin test with the muscarinic receptor agonists xanomeline and VU0152100. Spinal cord tissue from the naked mole-rat was used for receptor saturation binding studies...... with [3H]-N-methylscopolamine. The BLAST test revealed 95 % protein sequence homology showing the naked mole-rat to have the genetic potential to express all five muscarinic acetylcholine receptor subtypes. A significant reduction in pain behavior was demonstrated after administration of 8.4 mg/kg in...

  18. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

    OpenAIRE

    Tian, Xiao; Azpurua, Jorge; Ke, Zhonghe; Augereau, Adeline; Zhang, Zhengdong D.; Vijg, Jan; Gladyshev, Vadim N; Gorbunova, Vera; Seluanov, Andrei

    2014-01-01

    The naked mole rat is a longest lived and cancer-resistant rodent. Tumor resistance in the naked mole rat is mediated by signals from the extracellular matrix component hyaluronan triggering the induction of INK4 (inhibitors of cyclin dependent kinase 4) locus expression. The human and mouse INK4 locus encodes three critical tumor-suppressor proteins, p15INK4b, ARF (alternate reading frame), and p16INK4a, which are among the most frequently mutated in cancer. Furthermore, p16INK4a is implicat...

  19. The Robo-AO automated intelligent queue system

    CERN Document Server

    Riddle, Reed L; Papadopoulos, Athanasios; Baranec, Christoph; Law, Nicholas M

    2014-01-01

    Robo-AO is the first automated laser adaptive optics instrument. In just its second year of scientific operations, it has completed the largest adaptive optics surveys to date, each comprising thousands of targets. Robo-AO uses a fully automated queue scheduling system that selects targets based on criteria entered on a per observing program or per target basis, and includes the ability to coordinate with US Strategic Command automatically to avoid lasing space assets. This enables Robo-AO to select among thousands of targets at a time, and achieve an average observation rate of approximately 20 targets per hour.

  20. Resposta de cultivares de arroz irrigado ao nitrogênio

    OpenAIRE

    Freitas José Guilherme de; Azzini Luiz Ernesto; Cantarella Heitor; Bastos Cândido Ricardo; Castro Lúcia Helena Signori Melo de; Gallo Paulo Boller; Felício João Carlos

    2001-01-01

    Genótipos de arroz irrigado por inundação (Oryza sativa L.) podem apresentar variabilidade de resposta ao nitrogênio. O objetivo deste trabalho foi avaliar a resposta de três cultivares de arroz ao nitrogênio. Os experimentos foram realizados em Mococa, SP, em 1997/98 e 1998/99, em Cambissolo Háplico Tb Eutrófico gleico. O delineamento estatístico foi em blocos ao acaso, em esquema de parcelas subdivididas, com quatro repetições. Nas parcelas foram aplicadas doses de N (0, 50, 100 e 150 kg ha...

  1. Condicionantes economicos oa adoçao de uma inovaçao por parte do consumidor: analise da compra de serviços online

    OpenAIRE

    Izquierdo Yusta, Alicia; Martinez Ruiz, Maria Pilar; Jimenez Zarco, Ana Isabel

    2011-01-01

    Este  trabalho analisa a processo de adoçao de uma inovaçao concreta por parte do consumidor final -neste caso, o usa e adoçao de internet como canal de informaçao e de compra– na aquisiçao de um serviço, No caso concreto, considera-se um serviço turistico de caracteristicas muito particulares como e a reserva de um pernoite hoteleiro. A eleiçao deste produto intangivel resulta numa grande contribuçao a Iiteratura relevante, nao só pela escassez de trabalhos anteriores que tenham analisado es...

  2. Parentage analysis of Ansell’s mole-rat family groups indicates a high reproductive skew despite relatively relaxed ecological constraints on dispersal

    Czech Academy of Sciences Publication Activity Database

    Patzenhauerová, Hana; Šklíba, J.; Bryja, Josef; Šumbera, R.

    2013-01-01

    Roč. 22, č. 19 (2013), s. 4988-5000. ISSN 0962-1083 R&D Projects: GA AV ČR IAA601410802; GA ČR GAP506/10/0983 Institutional support: RVO:68081766 Keywords : African mole-rat * dispersal * eusociality * Fukomys * mating system * reproductive skew Subject RIV: EH - Ecology, Behaviour Impact factor: 5.840, year: 2013

  3. An efficient algorithm for generating AoA networks

    CERN Document Server

    Mouhoub, Nasser Eddine

    2012-01-01

    The activities, in project scheduling, can be represented graphically in two different ways, by either assigning the activities to the nodes 'AoN' directed acyclic graph (dag) or to the arcs 'AoA dag'. In this paper, a new algorithm is proposed for generating, for a given project scheduling problem, an Activity-on-Arc dag starting from the Activity-on-Node dag using the concepts of line graphs of graphs.

  4. A Large-Telescope Natural Guide Star AO System

    Science.gov (United States)

    Redding, David; Milman, Mark; Needels, Laura

    1994-01-01

    None given. From overview and conclusion:Keck Telescope case study. Objectives-low cost, good sky coverage. Approach--natural guide star at 0.8um, correcting at 2.2um.Concl- Good performance is possible for Keck with natural guide star AO system (SR>0.2 to mag 17+).AO-optimized CCD should b every effective. Optimizing td is very effective.Spatial Coadding is not effective except perhaps at extreme low light levels.

  5. Quitosana no controle pós-colheita da podridão mole em caqui 'rama forte' Chitosan on the postharvest control of soft rot in 'rama forte' persimmon

    Directory of Open Access Journals (Sweden)

    Patrícia Cia

    2010-01-01

    Full Text Available Este trabalho objetivou avaliar o efeito da quitosana, aliada ao processo de destanização, no controle de Rhizopus stolonifer em caqui 'Rama Forte' e sobre o crescimento micelial do fungo in vitro. Caquis foram submetidos ao processo de destanização com CO2 (70% / 18 horas, em tambores herméticos, sendo em seguida submetidos à inoculação com suspensão de esporos de R. stolonifer (3x10(5 esporos mL-1. Após inoculação, os frutos permaneceram por 2 horas a 25 °C, quando foram imersos em quitosana (0; 0,5; 1,0; 1,5 e 2,0%, por 1 minuto. Os frutos foram mantidos a 25 °C / 80% UR e avaliados quanto à severidade e incidência da podridão mole, durante cinco dias. Após o período de armazenamento, avaliaram-se a coloração de casca, a firmeza e o índice de adstringência. In vitro, avaliou-se o crescimento micelial em placas contendo meio BDA incorporado com quitosana ou ácido cítrico. Os resultados mostraram que a quitosana, a 1,5%, reduz a severidade e a incidência da podridão mole em caquis e não influencia no processo de perda de adstringência, firmeza e na coloração de casca. In vitro, a quitosana inibe completamente o crescimento micelial de R. stolonifer, em concentração tão baixa quanto 0,5%.The objective of this research was to evaluate the effect of chitosan in addition to de-astringency process on the control of Rhizopus stolonifer in 'Rama Forte' persimmon and on in vitro mycelial growth. Persimmon were submitted to de-astringency process using CO2 (70% / 18 h, in hermetic chambers. Next, fruit were inoculated through subcuticular injections of a R. stolonifer spore suspension (3x10(5 spore mL-1 and 2 hours later at 25 °C immersed into chitosan (0, 0.5, 1.0, 1.5, and 2.0%, for 1 min. Fruit were stored at 25 °C / 80% RH, and checked for rot severity and incidence of soft rot, during 5-days of storage. After storage the skin color, firmness and astringency index were evaluated in persimmons. In vitro, mycelial

  6. Seasonality and interannual variability of CH4 fluxes from the eastern Amazon Basin inferred from atmospheric mole fraction profiles

    Science.gov (United States)

    Basso, Luana S.; Gatti, Luciana V.; Gloor, Manuel; Miller, John B.; Domingues, Lucas G.; Correia, Caio S. C.; Borges, Viviane F.

    2016-01-01

    The Amazon Basin is an important region for global CH4 emissions. It hosts the largest area of humid tropical forests, and around 20% of this area is seasonally flooded. In a warming climate it is possible that CH4 emissions from the Amazon will increase both as a result of increased temperatures and precipitation. To examine if there are indications of first signs of such changes we present here a 13 year (2000-2013) record of regularly measured vertical CH4 mole fraction profiles above the eastern Brazilian Amazon, sensitive to fluxes from the region upwind of Santarém (SAN), between SAN and the Atlantic coast. Using a simple mass balance approach, we find substantial CH4 emissions with an annual average flux of 52.8 ± 6.8 mg CH4 m-2 d-1 over an area of approximately 1 × 106 km2. Fluxes are highest in two periods of the year: in the beginning of the wet season and during the dry season. Using a CO:CH4 emission factor estimated from the profile data, we estimated a contribution of biomass burning of around 15% to the total flux in the dry season, indicating that biogenic emissions dominate the CH4 flux. This 13 year record shows that CH4 emissions upwind of SAN varied over the years, with highest emissions in 2008 (around 25% higher than in 2007), mainly during the wet season, representing 19% of the observed global increase in this year.

  7. Recognition and Release of Nalidixic Acid Using Uniformly Sized -Imprinted Nanospheres: Methacrylic Acid to Methyl Methacrylate Different Mole Ratios

    Directory of Open Access Journals (Sweden)

    Mehdi Forouzani

    2013-01-01

    Full Text Available In the presence of imprinting molecules of Nalidixic acid, uniformly sized molecularly imprinted polymers (MIPs in nanometer range were synthesized. The MIPs were successfully prepared by precipitation polymerization using methacrylic acid (MAA and methyl methacrylate (MMA as functional monomers at different mole ratios. The effect of combination of MAA-to-MMA on the morphology, binding, recognition and release behaviors of the final particles were studied. The produced polymers were characterized by differential scanning calorimetry and their morphology was precisely examined by scanning electron microscopy. We obtained very uniform imprinted nanospheres with diameter of 120- 180 nm. Among the MIP nanospheres the MIPs using combination of MAA and MMA showed nanospheres with lowest mean diameter (120 nm and the highest selectivity factor (9.7. The adsorption properties of Nalidixic acid in acetonitrile for imprinted nanospheres were evaluated by equilibrium rebinding experiments. Results from binding experiments proved that MIPs exhibit specific affinity to Nalidixic acid in contrast to control polymers and this performance was affected by pH of loading solution and. Moreover, release experiments showed the controlled release of Nalidixic acid in longtime period. The loaded Nalidixic acid was released from the imprinted nanospheres within the 140 h.

  8. Recurrent hydatidiform mole: A case report of six consecutive molar pregnancies complicated by choriocarcinoma, and review of the literature

    Directory of Open Access Journals (Sweden)

    Ahlam A Al-Ghamdi

    2011-01-01

    Full Text Available Hydatidiform mole (HM is the most common form of gestational trophoblastic neoplasia. Recurrence of HM is extremely rare. Here, we report the case of a patient with six consecutive partial HMs without normal pregnancy. A 42-year-old lady who was referred to us at King Fahad Hospital of the University, Al Khobar, initially as a case of 26-year-old with persistent trophoblastic disease after three recurrent molar pregnancies that were confirmed histologically in the referring hospital. She underwent evacuation and curettage and was followed up by serial β-human chorionic gonadotropin levels, and did not require chemotherapy. She then had three more molar pregnancies in 1995, 1996, and 2004; all molar pregnancies were evacuated by suction curettage at her base hospital, but in the last event, she complained of shortness of breath and abdominal pain. Diagnostic workup in our hospital confirmed choriocarcinoma, for which she received multiple regimen chemotherapy and was cured. Unfortunately, she lately presented with symptoms suggestive of premature menopause.

  9. Raman Scattering and t-Phase Lattice Vibration of 3% (mole fraction) Y2O3-ZrO2

    Institute of Scientific and Technical Information of China (English)

    Xinglun TANG; Xiuhua ZHENG

    2004-01-01

    The Raman spectra of 3% (mole fraction) Y2O3-ZrO2 (3Y) are obtained at different temperature from 77 K to 853 K. The results show that 260 cm-1 Eg and 460 cm-1 Eg modes on the spectra shift toward lower wave number with the increase of temperature; meanwhile, the continuity of the Half Width at Half Maximum (HWHM) and wave number (frequency) of Raman bands are broken and t-phase only partially transforms to m-phase at 523 K. Based on the experimental results, this paper discusses the t-phase lattice vibration of 3Y and presents the images of vibration displacement of six Raman-active modes for t-phase of ZrO2. The analysis indicates that there are diversities existing in the displacement of the atomic vibration of Raman-active modes because of their different symmetries at various temperature, which leads to the different change tendencies of Raman bands. Furthermore, the abrupt changes of some Raman-active modes indicating the atomic displacement are assumed to be the condensations of phonon modes in the t→m phase transition.

  10. Twin pregnancy and partial hydatidiform mole following in vitro fertilization and embryos transfer: a novel case of placental mosaicism

    Institute of Scientific and Technical Information of China (English)

    SUN Cheng-juan; ZHAO You-ping; YU Song; FAN Ling; WU Qing-qing; LI Guang-hui; ZHANG Wei-yuan

    2012-01-01

    Twin pregnancy with mosaic partial hydatidiform mole (PHM) and survival of two healthy fetuses following in vitro fertilization and embryos transfer (IVF-ET) is a rare situation and is considered a challenge for management.A 32-year-old Chinese woman conceived twin pregnancy following IVF-ET.At 22 weeks' gestation,an additional intrauterine echogenic mass with features of PHM were shown by successive ultrasound examinations.At 35 weeks'gestation,two live male infants and two placentas were delivered by caesarean section (CS).Histologic examination of the abnormal placenta confirmed mosaic PHM.Genetic study showed the abnormal placental mosaicism (expressed in molar-69XXY and normal vili-46XY),co-existing with a hypospadia new-born (46XY) in one amniotic sac.However,the other one was normal.Serial serum β-hCG levels showed a declining trend and serum 3-human chorionic gonadotropin (hCG) were undetectable at 6 months after delivery.The case demonstrated that it is possible to prolonged gestation by PHM under close surveillance during the entire pregnancy.

  11. Performance of N2O and CO analyser for high-precision measurements of atmospheric mole fractions

    Science.gov (United States)

    Stanley, Kieran; O'Doherty, Simon

    2016-04-01

    N2O and CO are two important biogenic and anthropogenic greenhouse gases. N2O has a global warming potential approximately 300 times greater than CO2 on a per-molecule basis over a 100 year time horizon and is one of the most important factors affecting stratospheric ozone depletion. CO is a key gas in tropospheric photochemistry, constraining OH concentrations in the unpolluted atmosphere and the oxidising capacity in the troposphere. Due to the importance of N2O and CO as greenhouse and ozone depleting gases, precise high-frequency measurements of the two gases are necessary to better understand atmospheric mixing ratios. A number of different methods are available to measure the two gases, mainly based on chromatographic and reduction methods. The chromatographic method used to quantify atmospheric N2O mole fractions has not yet reached the WMO compatibility goal of ± 0.1 ppb. Over the past few years, new analytical techniques based on optical spectroscopy have been developed and become commercially available, providing near-real time data to high precision. In this presentation, we will give an overview of the performance of an Off Axis-Integrated Cavity Output Spectroscopy analyser with improvements made to temperature and pressure stability by the Scripps Institute of Oceanography. Results of the continuous repeatability measurement (referred to as precision by the manufacturers), short- and long-term repeatability, drift, temperature dependence, instrument linearity and H2O sensitivity will be presented.

  12. Effect of radiolysis on leachability of plutonium and americium from 76-101 glass. [Glass containing 2 mole % plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Nash, K.L.; Fried, S.; Friedman, A.M.; Susak, N.; Rickert, P.; Sullivan, J.C.; Karim, D.P.; Lam, D.J.

    1982-01-01

    One aspect of the leachability of actinide-bearing glass which has not been adequately addressed is the effect of radiolysis of the system (glass-water) on the amount of actinides liberated from the glass. In the present study, we have investigated the leaching of plutonium and americium from 76-101 glass samples (containing 2 mole % plutonium) in the presence of a one megaRad/hour gamma-radiation field. The presence of the radiation field was found to increase the leaching rate of both plutonium and americium by a factor of five. Speciation studies of the plutonium in the leachate indicate that the plutonium is present predominantly in the higher oxidation states, Pu(V) and Pu(VI) and that it is significantly associated with colloidal particles. Examination of the glass surfaces with x-ray photoemission spectroscopy, XPS, both before and after leaching was carried out; these studies showed lower surface concentrations of plutonium in the samples of glass leached in the radiation field. 1 figure, 3 tables.

  13. Atypical Mole (Atypical Nevus)

    Science.gov (United States)

    ... melanoma). Remember the ABCDEs of melanoma lesions: A - Asymmetry: One half of the lesion does not mirror ... York: Mosby, 2003. Last Updated: 22 Dec 2008 Information for other ages: Child Teen Table of Contents: ...

  14. Long-term analysis of carbon dioxide and methane column-averaged mole fractions retrieved from SCIAMACHY

    Directory of Open Access Journals (Sweden)

    O. Schneising

    2011-03-01

    Full Text Available Carbon dioxide (CO2 and methane (CH4 are the two most important anthropogenic greenhouse gases contributing to global climate change. SCIAMACHY onboard ENVISAT (launch 2002 was the first and is now with TANSO onboard GOSAT (launch 2009 one of only two satellite instruments currently in space whose measurements are sensitive to CO2 and CH4 concentration changes in the lowest atmospheric layers where the variability due to sources and sinks is largest.

    We present long-term SCIAMACHY retrievals (2003–2009 of column-averaged dry air mole fractions of both gases (denoted XCO2 and XCH4 derived from absorption bands in the near-infrared/shortwave-infrared (NIR/SWIR spectral region focusing on large-scale features. The results are obtained using an upgraded version (v2 of the retrieval algorithm WFM-DOAS including several improvements, while simultaneously maintaining its high processing speed. The retrieved mole fractions are compared to global model simulations (CarbonTracker XCO2 and TM5 XCH4 being optimised by assimilating highly accurate surface measurements from the NOAA/ESRL network and taking the SCIAMACHY averaging kernels into account. The comparisons address seasonal variations and long-term characteristics.

    The steady increase of atmospheric carbon dioxide primarily caused by the burning of fossil fuels can be clearly observed with SCIAMACHY globally. The retrieved global annual mean XCO2 increase agrees with CarbonTracker within the error bars (1.80±0.13 ppm yr−1 compared to 1.81±0.09 ppm yr−1. The amplitude of the XCO2 seasonal cycle as retrieved by SCIAMACHY, which is 4.3±0.2 ppm for the Northern Hemisphere and 1.4±0.2 ppm for the Southern Hemisphere, is on average about 1 ppm larger than for CarbonTracker.

    An investigation of the boreal forest carbon uptake during the

  15. Second generation Robo-AO instruments and systems

    CERN Document Server

    Baranec, Christoph; Law, Nicholas M; Chun, Mark R; Lu, Jessica R; Connelley, Michael S; Hall, Donald; Atkinson, Dani; Jacobson, Shane

    2014-01-01

    The prototype Robo-AO system at the Palomar Observatory 1.5-m telescope is the world's first fully automated laser adaptive optics instrument. Scientific operations commenced in June 2012 and more than 12,000 observations have since been performed at the ~0.12" visible-light diffraction limit. Two new infrared cameras providing high-speed tip-tilt sensing and a 2' field-of-view will be integrated in 2014. In addition to a Robo-AO clone for the 2-m IGO and the natural guide star variant KAPAO at the 1-m Table Mountain telescope, a second generation of facility-class Robo-AO systems are in development for the 2.2-m University of Hawai'i and 3-m IRTF telescopes which will provide higher Strehl ratios, sharper imaging, ~0.07", and correction to {\\lambda} = 400 nm.

  16. Comparison of nitrous oxide (N2O) analyzers for high-precision measurements of atmospheric mole fractions

    Science.gov (United States)

    Lebegue, Benjamin; Schmidt, Martina; Ramonet, Michel; Wastine, Benoit; Yver Kwok, Camille; Laurent, Olivier; Belviso, Sauveur; Guemri, Ali; Philippon, Carole; Smith, Jeremiah; Conil, Sebastien

    2016-03-01

    Over the last few decades, in situ measurements of atmospheric N2O mole fractions have been performed using gas chromatographs (GCs) equipped with electron capture detectors. This technique, however, becomes very challenging when trying to detect the small variations of N2O as the detectors are highly nonlinear and the GCs at remote stations require a considerable amount of maintenance by qualified technicians to maintain good short-term and long-term repeatability. With new robust optical spectrometers now available for N2O measurements, we aim to identify a robust and stable analyzer that can be integrated into atmospheric monitoring networks, such as the Integrated Carbon Observation System (ICOS). In this study, we present the most complete comparison of N2O analyzers, with seven analyzers that were developed and commercialized by five different companies. Each instrument was characterized during a time period of approximately 8 weeks. The test protocols included the characterization of the short-term and long-term repeatability, drift, temperature dependence, linearity and sensitivity to water vapor. During the test period, ambient air measurements were compared under field conditions at the Gif-sur-Yvette station. All of the analyzers showed a standard deviation better than 0.1 ppb for the 10 min averages. Some analyzers would benefit from improvements in temperature stability to reduce the instrument drift, which could then help in reducing the frequency of calibrations. For most instruments, the water vapor correction algorithms applied by companies are not sufficient for high-precision atmospheric measurements, which results in the need to dry the ambient air prior to analysis.

  17. Defective pericyte recruitment of villous stromal vessels as the possible etiologic cause of hydropic change in complete hydatidiform mole.

    Directory of Open Access Journals (Sweden)

    Kyu Rae Kim

    Full Text Available The pathogenetic mechanism underlying the hydropic change in complete hydatidiform moles (CHMs is poorly understood. A growing body of data suggests that pericytes play a role in vascular maturation. Since maturation of villous stromal vessels in CHMs is markedly impaired at early stages, we postulated that a defect in pericytes around stromal vessels in chorionic villi might cause vascular immaturity and subsequent hydropic change. To investigate this, we examined several markers of pericytes, namely, α-smooth muscle actin (α-SMA, platelet-derived growth factor receptor-β (PDGFR-β, and desmin, in 61 normally developing placentas and 41 CHMs with gestational ages of 4-12 weeks. The ultrastructure of villous stromal vessels was also examined. Mature blood vessels from normal placentas show patent vascular lumens and formed hematopoietic components in the villous stroma. α-SMA and PDGFR-β expression in the villous stroma gradually increased and extended from the chorionic plate to peripheral villous branches. The labeled cells formed a reticular network in the villous stroma and, after week 7, encircled villous stromal vessels. In comparison, α-SMA and PDGFR-β expression in the villous stroma and stromal vessels of CHMs was significantly lower (p<0.05. Ultrastructurally, endothelial cells in villous stromal vessels in normal placentas were consistently attached by pericytes after week 7 when the vessels formed distinct lumen, whereas the villous stromal vessels in CHMs consisted of linear chains of endothelial cells, often disclosing primitive clefts without hematopoietic cells inside, and neither pericytes nor basal lamina surrounded the endothelial cells at any gestational age studied. This suggests that pericytes recruitment around villous stromal vessels is defective in CHMs and links to the persistent vascular immaturity of the villous stroma in CHMs, which in turns leads to hydropic villi.

  18. Non-Breeding Eusocial Mole-Rats Produce Viable Sperm--Spermiogram and Functional Testicular Morphology of Fukomys anselli.

    Directory of Open Access Journals (Sweden)

    Angelica Garcia Montero

    Full Text Available Ansell's mole-rats (Fukomys anselli are subterranean rodents living in families composed of about 20 members with a single breeding pair and their non-breeding offspring. Most of them remain with their parents for their lifetime and help to maintain and defend the natal burrow system, forage, and care for younger siblings. Since incest avoidance is based on individual recognition (and not on social suppression we expect that non-breeders produce viable sperm spontaneously. We compared the sperm of breeding and non-breeding males, obtained by electroejaculation and found no significant differences in sperm parameters between both groups. Here, we used electroejaculation to obtain semen for the first time in a subterranean mammal. Spermiogram analysis revealed no significant differences in sperm parameters between breeders and non-breeders. We found significantly larger testes (measured on autopsies and on living animals per ultrasonography of breeders compared to non-breeders (with body mass having a significant effect. There were no marked histological differences between breeding and non-breeding males, and the relative area occupied by Leydig cells and seminiferous tubules on histological sections, respectively, was not significantly different between both groups. The seminiferous epithelium and to a lesser degree the interstitial testicular tissue are characterized by lesions (vacuolar degenerations, however, this feature does not hinder fertilization even in advanced stages of life. The continuous production of viable sperm also in sexually abstinent non-breeders might be best understood in light of the mating and social system of Fukomys anselli, and the potential to found a new family following an unpredictable and rare encounter with an unfamiliar female ("provoked or induced dispersal". Apparently, the non-breeders do not reproduce because they do not copulate but not because they would be physiologically infertile. The significantly

  19. Non-Breeding Eusocial Mole-Rats Produce Viable Sperm--Spermiogram and Functional Testicular Morphology of Fukomys anselli.

    Science.gov (United States)

    Garcia Montero, Angelica; Vole, Christiane; Burda, Hynek; Malkemper, Erich Pascal; Holtze, Susanne; Morhart, Michaela; Saragusty, Joseph; Hildebrandt, Thomas B; Begall, Sabine

    2016-01-01

    Ansell's mole-rats (Fukomys anselli) are subterranean rodents living in families composed of about 20 members with a single breeding pair and their non-breeding offspring. Most of them remain with their parents for their lifetime and help to maintain and defend the natal burrow system, forage, and care for younger siblings. Since incest avoidance is based on individual recognition (and not on social suppression) we expect that non-breeders produce viable sperm spontaneously. We compared the sperm of breeding and non-breeding males, obtained by electroejaculation and found no significant differences in sperm parameters between both groups. Here, we used electroejaculation to obtain semen for the first time in a subterranean mammal. Spermiogram analysis revealed no significant differences in sperm parameters between breeders and non-breeders. We found significantly larger testes (measured on autopsies and on living animals per ultrasonography) of breeders compared to non-breeders (with body mass having a significant effect). There were no marked histological differences between breeding and non-breeding males, and the relative area occupied by Leydig cells and seminiferous tubules on histological sections, respectively, was not significantly different between both groups. The seminiferous epithelium and to a lesser degree the interstitial testicular tissue are characterized by lesions (vacuolar degenerations), however, this feature does not hinder fertilization even in advanced stages of life. The continuous production of viable sperm also in sexually abstinent non-breeders might be best understood in light of the mating and social system of Fukomys anselli, and the potential to found a new family following an unpredictable and rare encounter with an unfamiliar female ("provoked or induced dispersal"). Apparently, the non-breeders do not reproduce because they do not copulate but not because they would be physiologically infertile. The significantly increased testes

  20. Non-Breeding Eusocial Mole-Rats Produce Viable Sperm—Spermiogram and Functional Testicular Morphology of Fukomys anselli

    Science.gov (United States)

    Garcia Montero, Angelica; Vole, Christiane; Burda, Hynek; Malkemper, Erich Pascal; Holtze, Susanne; Morhart, Michaela; Saragusty, Joseph; Hildebrandt, Thomas B.; Begall, Sabine

    2016-01-01

    Ansell’s mole-rats (Fukomys anselli) are subterranean rodents living in families composed of about 20 members with a single breeding pair and their non-breeding offspring. Most of them remain with their parents for their lifetime and help to maintain and defend the natal burrow system, forage, and care for younger siblings. Since incest avoidance is based on individual recognition (and not on social suppression) we expect that non-breeders produce viable sperm spontaneously. We compared the sperm of breeding and non-breeding males, obtained by electroejaculation and found no significant differences in sperm parameters between both groups. Here, we used electroejaculation to obtain semen for the first time in a subterranean mammal. Spermiogram analysis revealed no significant differences in sperm parameters between breeders and non-breeders. We found significantly larger testes (measured on autopsies and on living animals per ultrasonography) of breeders compared to non-breeders (with body mass having a significant effect). There were no marked histological differences between breeding and non-breeding males, and the relative area occupied by Leydig cells and seminiferous tubules on histological sections, respectively, was not significantly different between both groups. The seminiferous epithelium and to a lesser degree the interstitial testicular tissue are characterized by lesions (vacuolar degenerations), however, this feature does not hinder fertilization even in advanced stages of life. The continuous production of viable sperm also in sexually abstinent non-breeders might be best understood in light of the mating and social system of Fukomys anselli, and the potential to found a new family following an unpredictable and rare encounter with an unfamiliar female (“provoked or induced dispersal”). Apparently, the non-breeders do not reproduce because they do not copulate but not because they would be physiologically infertile. The significantly increased

  1. Pigmentary Markers in Danes - Associations with Quantitative Skin Colour, Nevi Count, Familial Atypical Multiple-Mole, and Melanoma Syndrome.

    Directory of Open Access Journals (Sweden)

    Peter Johansen

    Full Text Available To investigate whether pigmentation genes involved in the melanogenic pathway (melanogenesis contributed to melanoma predisposition, we compared pigmentary genetics with quantitative skin pigmentation measurements, the number of atypical nevi, the total nevus count, and the familial atypical multiple mole and melanoma (FAMMM syndrome. We typed 32 pigmentary SNP markers and sequenced MC1R in 246 healthy individuals and 116 individuals attending periodic control for malignant melanoma development, 50 of which were diagnosed with FAMMM. It was observed that individuals with any two grouped MC1R variants (missense, NM_002386:c. 456C > A (p.TYR152*, or NM_002386:c.83_84insA (p.Asn29Glnfs*14 had significantly (p<0.001 lighter skin pigmentation of the upper-inner arm than those with none or one MC1R variant. We did not observe any significant association of the MC1R variants with constitutive pigmentation measured on the buttock area. We hypothesize that the effect of MC1R variants on arm pigmentation is primarily reflecting the inability to tan when subjected to UVR. A gender specific effect on skin pigmentation was also observed, and it was found that the skin pigmentation of females on average were darker than that of males (p<0.01. We conclude that MC1R variants are associated with quantitative skin colour in a lightly pigmented Danish population. We did not observe any association between any pigmentary marker and the FAMMM syndrome. We suggest that the genetics of FAMMM is not related to the genetics of the pigmentary pathway.

  2. Immunohistochemical characterization of the chemosensory pulmonary neuroepithelial bodies in the naked mole-rat reveals a unique adaptive phenotype.

    Directory of Open Access Journals (Sweden)

    Jie Pan

    Full Text Available The pulmonary neuroepithelial bodies (NEBs constitute polymodal airway chemosensors for monitoring and signaling ambient gas concentrations (pO2, pCO2/H+ via complex innervation to the brain stem controlling breathing. NEBs produce the bioactive amine, serotonin (5-HT, and a variety of peptides with multiple effects on lung physiology and other organ systems. NEBs in mammals appear prominent and numerous during fetal and neonatal periods, and decline in the post-natal period suggesting an important role during perinatal adaptation. The naked mole-rat (NMR, Heterocephalus glaber, has adapted to the extreme environmental conditions of living in subterranean burrows in large colonies (up to 300 colony mates. The crowded, unventilated burrows are environments of severe hypoxia and hypercapnia. However, NMRs adjust readily to above ground conditions. The chemosensory NEBs of this species were characterized and compared to those of the conventional Wistar rat (WR to identify similarities and differences that could explain the NMR's adaptability to environments. A multilabel immunohistochemical analysis combined with confocal microscopy revealed that the expression patterns of amine, peptide, neuroendocrine, innervation markers and chemosensor component proteins in NEBs of NMR were similar to that of WR. However, we found the following differences: 1 NEBs in both neonatal and adult NMR lungs were significantly larger and more numerous as compared to WR; 2 NEBs in NMR had a more variable compact cell organization and exhibited significant differences in the expression of adhesion proteins; 3 NMR NEBs showed a significantly greater ratio of 5-HT positive cells with an abundance of 5-HT; 4 NEBs in NMR expressed the proliferating cell nuclear antigen (PCNA and the neurogenic gene (MASH1 indicating active proliferation and a state of persistent differentiation. Taken together our findings suggest that NEBs in lungs of NMR are in a hyperactive, functional

  3. Comparison of nitrous oxide (N2O) analyzers for high-precision measurements of atmospheric mole fractions

    Science.gov (United States)

    Lebegue, B.; Schmidt, M.; Ramonet, M.; Wastine, B.; Yver Kwok, C.; Laurent, O.; Belviso, S.; Guemri, A.; Philippon, C.; Smith, J.; Conil, S.; Jost, H. J.; Crosson, E. R.

    2015-10-01

    Over the last few decades, in-situ measurements of atmospheric N2O mole fractions have been performed using gas chromatographs (GCs) equipped with electron capture detectors (ECDs). When trying to meet the World Meteorological Organization's (WMO) quality goal, this technique becomes very challenging as the detectors are highly non-linear and the GCs at remote stations require a considerable amount of maintenance by qualified technicians to maintain good short-term and long-term repeatability. With more robust optical spectrometers being now available for N2O measurements, we aim to identify a robust and stable analyzer that can be integrated into atmospheric monitoring networks, such as the Integrated Carbon Observation System (ICOS). In this study, we tested seven analyzers that were developed and commercialized from five different companies and compared the results with established techniques. Each instrument was characterized during a time period of approximately eight weeks. The test protocols included the characterization of the short-term and long-term repeatability, drift, temperature dependence, linearity and sensitivity to water vapor. During the test period, ambient air measurements were compared under field conditions at the Gif-sur-Yvette station. All of the analyzers showed a standard deviation better than 0.1 ppb for the 10 min averages. Some analyzers would benefit from improvements in temperature stability to reduce the instrument drift, which could then help in reducing the frequency of calibrations. For most instruments, the water vapor correction algorithms applied by companies are not sufficient for high-precision atmospheric measurements, which results in the need to dry the ambient air prior to analysis.

  4. Diffraction-limited Visible Light Images of Orion Trapezium Cluster With the Magellan Adaptive Secondary AO System (MagAO)

    CERN Document Server

    Close, L M; Morzinski, K; Kopon, D; Follette, K; Rodigas, T J; Hinz, P; Wu, Y-L; Puglisi, A; Esposito, S; Riccardi, A; Pinna, E; Xompero, M; Briguglio, R; Uomoto, A; Hare, T

    2013-01-01

    We utilized the new high-order (250-378 mode) Magellan Adaptive Optics system (MagAO) to obtain very high spatial resolution observations in "visible light" with MagAO's VisAO CCD camera. In the good-median seeing conditions of Magellan (0.5-0.7") we find MagAO delivers individual short exposure images as good as 19 mas optical resolution. Due to telescope vibrations, long exposure (60s) r' (0.63 micron) images are slightly coarser at FWHM=23-29 mas (Strehl ~28%) with bright (R<9 mag) guide stars. These are the highest resolution filled-aperture images published to date. Images of the young (~1 Myr) Orion Trapezium Theta 1 Ori A, B, and C cluster members were obtained with VisAO. In particular, the 32 mas binary Theta 1 Ori C1/C2 was easily resolved in non-interferometric images for the first time. Relative positions of the bright trapezium binary stars were measured with ~0.6-5 mas accuracy. We now are sensitive to relative proper motions of just ~0.2 mas/yr (~0.4 km/s at 414 pc) - this is a ~2-10x improv...

  5. Impact of underlap and mole-fraction on RF performance of strained-Si/Si1-xGex/strained-Si DG MOSFETs

    Science.gov (United States)

    Dutta, Arka; Koley, Kalyan; Sarkar, Chandan K.

    2014-11-01

    In this paper, a systematic RF performance analysis of double-gate strained silicon (DGSS) nMOSFETs is presented. The analysis is focused upon impact of Germanium mole-fraction variation on RF performance of underlap engineered DGSS nMOSFET. The RF performance of the device is analysed as a function of intrinsic RF figure of merits (FOMs) including non-quasi static effects (NQS). The RF FOMs are represented by the intrinsic gate to source/drain capacitance (Cgs and Cgd) and resistance (Rgs and Rgd), the transport delay (τm), the intrinsic inductance (Lsd), the cut-off frequency (fT), and the maximum oscillation frequency (fMAX). The results of the study suggested a significant improvement in the device performance, up to 40% increase in Germanium mole fraction (χ).

  6. Effects of the InAIN growth temperature and In mole fraction on subband transport in InxAI1-xN/(AIN)/GaN/AIN heterostructures

    International Nuclear Information System (INIS)

    Subband transport properties of the two-dimensional electron gas in InxAI1-xN/(AIN)/GaN/AIN heterostructures were investigated by means of variable magnetic-field Hall measurement between 30 K and 290 K. The experimental data was analyzed by using quantitative mobility spectrum analysis technique. The 2-dimensional electron gas with 1 or 2 subbands and the 2-dimensional hole were detected with i-quantitative mobility spectrum analysis technique. Mobility of the second subband of 2DEG was found to be higher than that of the first subband. The sheet carrier density for Hall, the first and the second subband were reduced while Indium mole fraction was increasing. This behavior is a result of total bound interface sheet density. During In mole fraction was increasing, second subband mobility was decreased.The first subband and Hall mobility was decreased once InAIN growth temperature was increased

  7. All About Portugal - Website dedicado ao turismo externo em Portugal

    OpenAIRE

    Martins, Rui Manuel da Silva

    2015-01-01

    Grande parte do tráfego online tem origem em páginas de resultados de motores de de pesquisa. Estes constituem hoje uma ferramenta fundamental de que os turistas se socorrem para pesquisar e filtrar a informação necessária ao planeamento das suas viagens, sendo, por isso, bastante tidos em conta pelas entidades ligadas ao turismo no momento da definição das suas estratégias de marketing. No presente documento é descrita a investigação feita em torno do modo de funcionamento ...

  8. Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat

    OpenAIRE

    Maja Dziegelewska; Susanne Holtze; Christiane Vole; Ulrich Wachter; Uwe Menzel; Michaela Morhart; Marco Groth; Karol Szafranski; Arne Sahm; Christoph Sponholz; Philip Dammann; Klaus Huse; Thomas Hildebrandt; Matthias Platzer

    2016-01-01

    Hydrogen sulfide (H2S) is a gaseous signalling molecule involved in many physiological and pathological processes. There is increasing evidence that H2S is implicated in aging and lifespan control in the diet-induced longevity models. However, blood sulfide concentration of naturally long-lived species is not known. Here we measured blood sulfide in the long-lived naked mole-rat and five other mammalian species considerably differing in lifespan and found a negative correlation between blood ...

  9. Tunable diode laser absorption spectroscopy-based tomography system for on-line monitoring of two-dimensional distributions of temperature and H2O mole fraction

    International Nuclear Information System (INIS)

    To monitor two-dimensional (2D) distributions of temperature and H2O mole fraction, an on-line tomography system based on tunable diode laser absorption spectroscopy (TDLAS) was developed. To the best of the authors’ knowledge, this is the first report on a multi-view TDLAS-based system for simultaneous tomographic visualization of temperature and H2O mole fraction in real time. The system consists of two distributed feedback (DFB) laser diodes, a tomographic sensor, electronic circuits, and a computer. The central frequencies of the two DFB laser diodes are at 7444.36 cm−1 (1343.3 nm) and 7185.6 cm−1 (1391.67 nm), respectively. The tomographic sensor is used to generate fan-beam illumination from five views and to produce 60 ray measurements. The electronic circuits not only provide stable temperature and precise current controlling signals for the laser diodes but also can accurately sample the transmitted laser intensities and extract integrated absorbances in real time. Finally, the integrated absorbances are transferred to the computer, in which the 2D distributions of temperature and H2O mole fraction are reconstructed by using a modified Landweber algorithm. In the experiments, the TDLAS-based tomography system was validated by using asymmetric premixed flames with fixed and time-varying equivalent ratios, respectively. The results demonstrate that the system is able to reconstruct the profiles of the 2D distributions of temperature and H2O mole fraction of the flame and effectively capture the dynamics of the combustion process, which exhibits good potential for flame monitoring and on-line combustion diagnosis

  10. Tunable diode laser absorption spectroscopy-based tomography system for on-line monitoring of two-dimensional distributions of temperature and H2O mole fraction

    Science.gov (United States)

    Xu, Lijun; Liu, Chang; Jing, Wenyang; Cao, Zhang; Xue, Xin; Lin, Yuzhen

    2016-01-01

    To monitor two-dimensional (2D) distributions of temperature and H2O mole fraction, an on-line tomography system based on tunable diode laser absorption spectroscopy (TDLAS) was developed. To the best of the authors' knowledge, this is the first report on a multi-view TDLAS-based system for simultaneous tomographic visualization of temperature and H2O mole fraction in real time. The system consists of two distributed feedback (DFB) laser diodes, a tomographic sensor, electronic circuits, and a computer. The central frequencies of the two DFB laser diodes are at 7444.36 cm-1 (1343.3 nm) and 7185.6 cm-1 (1391.67 nm), respectively. The tomographic sensor is used to generate fan-beam illumination from five views and to produce 60 ray measurements. The electronic circuits not only provide stable temperature and precise current controlling signals for the laser diodes but also can accurately sample the transmitted laser intensities and extract integrated absorbances in real time. Finally, the integrated absorbances are transferred to the computer, in which the 2D distributions of temperature and H2O mole fraction are reconstructed by using a modified Landweber algorithm. In the experiments, the TDLAS-based tomography system was validated by using asymmetric premixed flames with fixed and time-varying equivalent ratios, respectively. The results demonstrate that the system is able to reconstruct the profiles of the 2D distributions of temperature and H2O mole fraction of the flame and effectively capture the dynamics of the combustion process, which exhibits good potential for flame monitoring and on-line combustion diagnosis.

  11. Effect of hot pressing temperature on the electrochemical stability of Li2S-P2S5 (75 -- 25 % mole) as a solid electrolyte

    Science.gov (United States)

    Garcia Mendez, Maria Regina

    Solid state batteries can contribute to a more sustainable energy future providing the energy required when needed. It can facilitate the integration of renewable energy into the electrical grid and can provide the energy density required to make electric vehicles a massive technology without greenhouse emissions in operating conditions. To concretize the latter, high-performance electrolytes are necessary. Li2S-P2S5 (75-25% mole) is a promising solid-electrolyte that could potentially be used for this purpose. Its most appealing features include: high ionic conductivity at room temperature (~10-3 S/cm), low-temperature processing conditions, and low cost. Most likely, Li2S-P 2S5 (75-25% mole) would be integrated in a battery system using Li metal as an anode. Therefore, its stability against metallic lithium must be understood. The purpose of this work is to characterize the effect of Li2S-P2S5 (75-25% mole) processing conditions, most specifically hot pressing, and their effect on Li stability. It was found that improvements on electrochemical performance can be attained by promoting particle chemistry during hot pressing.

  12. Design and Implementation of Whac-a-mole Game Basd on PLD%基于PLD的打地鼠游戏的设计与实现

    Institute of Scientific and Technical Information of China (English)

    李倩

    2015-01-01

    Whack-a-mole game is a practical small game, entertainment is very strong, and can exercise the children's reaction speed, now on the market also appeared a lot of children's toys about whack-a-mole. This paper realized the basic function of the game of whack-a-mole, tells the story of the game design process, through the detailed design process for a beginner to understand the system design process based on PLD.%打地鼠游戏是一款实用性小游戏,娱乐性很强,且能够锻炼孩子们的反应速度,现在市面上也出现了很多关于打地鼠的儿童玩具。本文实现了的打地鼠游戏的基本功能,讲述了此游戏的设计实现过程,通过整个详细的设计过程让学习者了解到基于PLD的系统设计流程。

  13. Adenosine receptors mediate the hypoxic ventilatory response but not the hypoxic metabolic response in the naked mole rat during acute hypoxia.

    Science.gov (United States)

    Pamenter, Matthew E; Dzal, Yvonne A; Milsom, William K

    2015-02-01

    Naked mole rats are the most hypoxia-tolerant mammals identified; however, the mechanisms underlying this tolerance are poorly understood. Using whole-animal plethysmography and open-flow respirometry, we examined the hypoxic metabolic response (HMR), hypoxic ventilatory response (HVR) and hypoxic thermal response in awake, freely behaving naked mole rats exposed to 7% O₂ for 1 h. Metabolic rate and ventilation each reversibly decreased 70% in hypoxia (from 39.6 ± 2.9 to 12.1 ± 0.3 ml O₂ min(-1) kg(-1), and 1412 ± 244 to 417 ± 62 ml min(-1) kg(-1), respectively; p tolerant to hypoxia, and in some cases hypoxia was lethal following AMP injection. We conclude that in naked mole rats (i) hypoxia tolerance is partially dependent on profound hypoxic metabolic and ventilatory responses, which are equal in magnitude but occur independently of thermal changes in hypoxia, and (ii) adenosine receptors mediate the HVR but not the HMR. PMID:25520355

  14. Resposta ao estresse: II. Resiliência e vulnerabilidade

    Directory of Open Access Journals (Sweden)

    Nicole Leite Galvão-Coelho

    2015-06-01

    Full Text Available ResumoA crescente exposição a estressores na vida cotidiana aumentou significativamente a investigação da resposta ao estresse nas duas últimas décadas. Embora associada a consequências negativas, pois muitas patologias físicas e mentais são desencadeadas por exposição crônica a estressores, esta resposta é indispensável para sobrevivencia do indivíduo e é extremamente adaptativa quando ativada de forma aguda. Na parte I desta revisão foram abordados os conceitos de homestase e alostase e os sistemas fisiológicos ativados durante a resposta ao estresse. Na parte II serão discutidos fatores que modulam a resposta ao estresse tais como sexo, temperamento, períodos críticos do desenvolvimento e a presença ou ausência de suporte social. A interação entre os fatores genéticos e ambientais gera os perfis da resposta psicofisiológica que caracterizam os fenótipos de susceptibilidade e resiliência frente aos estressores e sua relação com uma patologia mental cada vez mais presente na sociedade moderna, o transtorno de estresse pós-traumático.

  15. On some Polychaetous Annelids from Curaçao

    NARCIS (Netherlands)

    Horst, R.

    1922-01-01

    Though we know already a rather large number of Polychaetous Annelids from the Caribbean Sea, hitherto, as far as I know, no Annelids have been described from the coast of the island Curaçao and I therefore was very glad, that my colleague Dr. VAN DER HORST kindly placed in my hands for identificati

  16. Role of the novel hydatidiform mole-related gene F10 in the tumorigenicity of choriocarcinoma cell line JAR

    Directory of Open Access Journals (Sweden)

    Xiao-hua SU

    2016-03-01

    Full Text Available Objective  To explore the role of the novel hydatidiform mole-related gene F10 in the tumorigenicity of choriocarcinoma cell line JAR in nude mice. Methods  By cell transfection and RNA interference, stable F10 gene over-expression and F10 gene-silenced JAR choriocarcinoma cell line were engendered. Thirty SPF nude mice (aged 4-5 weeks were randomly assigned into 3 groups (10 each: F10 overexpression group (inoculated with F10 gene-overexpressed JAR cells, control group (inoculated with non-treated JAR cells and F10 gene-silenced group (inoculated with F10 gene-silenced JAR cells. JAR cell suspension (0.2ml with 5×107 cells in each mouse were injected into the subcutaneous tissue of the back of mice neck. After injection, the conditions of the mice were observed, and they were weighed once every 3-4 days. The tumor formation time was recorded, the tumor growth curve was plotted, and tumor formation rate was calculated. The mice were sacrificed, and the subcutaneous tumor mass was weighed 5 weeks after the JAR cell injection. Results  The rate of tumor formation was 100% (10/10. There was no significant difference in tumor formation time (F=0.097, P=0.908 among the groups of F10 overexpression (4.4±1.1d, F10 silenced (4.4±1.1d, and control (4.6±1.3d. The growth rate of subcutaneous tumor in F10 overexpression group was significantly higher compared with groups of control and F10 silenced (P<0.05, and significant difference in tumor growth rate was found between control group and F10 silenced-expression group (P<0.05. The weight of tumor tissue was significantly different (F=14.462, P=0.000 among the groups of F10 overexpression (607.49±216.19mg, F10 silenced (270.73±81.53mg and control (423.87±74.75mg. Conclusion  F10 gene is involved in the proliferation of JAR choriocarcinoma cell line, and it might enhance the tumorigenicity of JAR cell line in nude mice. DOI: 10.11855/j.issn.0577-7402.2016.01.04

  17. [Richard C. M. Mole: The Baltic states from the Soviet Union to the European Union. Identity, discourse and power in the post-communist transition of Estonia, Latvia and Lithuania] / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2014-01-01

    Arvustus: Mole, Richard C. M. The Baltic States from the Soviet Union to the European Union : identity, discourse and power in the post-communist transition of Estonia, Latvia and Lithuania. London ; New York : Routledge, 2012, 2013

  18. Frequência de mola hidatiforme em tecidos obtidos por curetagem uterina Frequency of hydatidiform mole in tissue obtained by curettage

    Directory of Open Access Journals (Sweden)

    Andressa Biscaro

    2012-06-01

    Full Text Available OBJETIVO: Determinar a frequência de mola hidatiforme em tecidos obtidos por curetagem uterina. MÉTODOS: Estudo transversal, prospectivo e descritivo que incluiu pacientes submetidas à curetagem uterina por diagnóstico de aborto ou mola hidatiforme cujo material obtido foi encaminhado para exame anatomopatológico. Foram excluídas aquelas que não aceitaram participar da pesquisa, recusando-se a assinar o Termo de Consentimento Informado Livre e Esclarecido. Foram analisadas as seguintes variáveis: achados anatomopatológicos, idade, raça/cor, número de gestações e abortos prévios, idade gestacional no momento do diagnóstico, níveis séricos quantitativos da fração beta da gonadotrofina coriônica humana e achados ultrassonográficos. As variáveis foram empregadas para a verificação com o diagnóstico histológico, considerado o padrão-ouro. Os dados foram armazenados e analisados no software Microsoft Excel® e no programa Epi-Info, versão 6.0 (STATCALC e os resultados apresentados como frequência (porcentagem ou média±desvio padrão. Para a associação entre variáveis qualitativas foi usado o teste do χ², e admitiu-se significância estatística quando pPURPOSE: To determine the frequency of hydatiform mole in tissues obtained by curettage. METHODS: A cross-sectional, prospective and descriptive conducted on patients who underwent curretage due to a diagnosis of abortion or hydatiform mole whose material was sent for pathological examination. We excluded women who did not accept to participate and refused to sign the free informed consent form. We studied the following variables: pathological findings, age, race, number of pregnancies and previous abortions, gestational age at diagnosis, quantitative serum beta fraction of human chorionic gonadotropin and ultrasound findings. The data were compared to the to histological diagnosis, considered to be the gold standard. Data were stored and analyzed in Microsoft Excel

  19. Effect of Al mole fraction on structural and electrical properties of AlxGa1-xN/GaN heterostructures grown by plasma-assisted molecular beam epitaxy

    International Nuclear Information System (INIS)

    The effect of Al mole fractions on the structural and electrical properties of AlxGa1-xN/GaN thin films grown by plasma-assisted molecular beam epitaxy (PA-MBE) on Si (1 1 1) substrates has been investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and current-voltage (I-V) measurements. X-ray results revealed that the AlGaN/GaN/AlN was epitaxially grown on Si substrate. By applying Vegard's law, the Al mole fractions of AlxGa1-xN samples were found to be 0.11, 0.24, 0.30 and 0.43, respectively. The structural and morphology results indicated that there is a relatively larger tensile strain for the sample with the smallest Al mole fraction; while a smaller compressive strain and larger grain size appear with Al mole fraction equal to 0.30. The strain gets relaxed with the highest Al mole fraction sample. Finally, the linear relationship between the barrier height and Al mole fraction was obtained.

  20. Sobre a viagem de Enrico Fermi ao Brasil em 1934

    CERN Document Server

    Caruso, Francisco

    2014-01-01

    Enrico Fermi was one of the greater physicists of the XX century. In 1934, he gave several lectures in Brazil. Invited by Theodoro Ramos to work in S\\~ao Paulo, he preferred to stay in Rome and went to the USA in 1938. However, Fermi recommended Gleb Wataghin to come in his place. Wataghin made history in Brazil, becoming one of the first Professors of the future S\\~ao Paulo University. Besides his relevance to the History of Science, Fermi eventually leaved an indelible mark on the creation and institutionalization of national scientific research due to the indication of Wataghin. Despite this fact, very little is known about Fermi's trip to Brazil. This work tries to reconstruct the fullest possible steps of the famous Italian physicist in our lands.

  1. O prazer associado ao consumo de alimentos e factores influenciadores

    OpenAIRE

    Gomes, Filipe Gonçalo Ferreira

    2013-01-01

    Os indivíduos quando sujeitos a várias sensações transmitem respostas que surgem de reacções fisiológicas resultantes de certos estímulos, gerando a interpretação das propriedades intrínsecas aos alimentos, sendo a análise sensorial realizada em função dessas respostas individuais. As sensações são medidas por efeitos psicológicos, podendo dimensionar a intensidade, extensão, qualidade, duração, gosto ou desgosto em relação ao alimento avaliado, e os estímulos são medidos por processos físico...

  2. Diffraction limited operation with ARGOS: a hybrid AO system

    Science.gov (United States)

    Bonaglia, M.; Busoni, L.; Quirós-Pacheco, F.; Esposito, S.

    2010-07-01

    ARGOS, the Laser Guide Star (LGS) facility of the Large Binocular Telescope (LBT), implements a Ground Layer Adaptive Optics (GLAO) system, using 3 low-altitude beacons, to improve the resolution over the 4'×4' FoV of the imager and Multi Object Spectrograph (MOS) LUCIFER. In this paper we discuss the performance and the reconstruction scheme of an hybrid AO system using the ARGOS Rayleigh beacons complemented with a single faint high-altitude star (NGS or sodium beacon) to sense the turbulence of the upper atmosphere allowing an high degree of on-axis correction. With the ARGOS system, the NGS-upgrade can be immediately implemented at LBT using the already existing Pyramid WFS offering performance similar to the NGS AO system with the advantage of a larger sky coverage.

  3. Three years of greenhouse gas column-averaged dry air mole fractions retrieved from satellite – Part 1: Carbon dioxide

    Directory of Open Access Journals (Sweden)

    R. Macatangay

    2008-03-01

    Full Text Available Carbon dioxide (CO2 and methane (CH4 are the two most important anthropogenic greenhouse gases. SCIAMACHY on ENVISAT is the first satellite instrument whose measurements are sensitive to concentration changes of the two gases at all altitude levels down to the Earth's surface where the source/sink signals are largest. We have processed three years (2003–2005 of SCIAMACHY near-infrared nadir measurements to simultaneously retrieve vertical columns of CO2 (from the 1.58 μm absorption band, CH4 (1.66 μm and oxygen (O2 A-band at 0.76 μm using the scientific retrieval algorithm WFM-DOAS. We show that the latest version of WFM-DOAS, version 1.0, which is used for this study, has been significantly improved with respect to its accuracy compared to the previous versions while essentially maintaining its high processing speed (~1 minute per orbit, corresponding to ~6000 single measurements, and per gas on a standard PC. The greenhouse gas columns are converted to dry air column-averaged mole fractions, denoted XCO2 (in ppm and XCH4 (in ppb, by dividing the greenhouse gas columns by simultaneously retrieved dry air columns. For XCO2 dry air columns are obtained from the retrieved O2 columns. For XCH4 dry air columns are obtained from the retrieved CO2 columns because of better cancellation of light path related errors compared to using O2 columns retrieved from the spectrally distant O2 A-band. Here we focus on a discussion of the XCO2 data set. The XCH4 data set is discussed in a separate paper (Part 2. In order to assess the quality of the retrieved XCO2 we present comparisons with Fourier Transform Spectroscopy (FTS XCO2 measurements at two northern hemispheric mid-latitude ground stations. To assess the quality globally, we present detailed comparisons with global XCO2 fields obtained from NOAA's CO2 assimilation system CarbonTracker. For the Northern Hemisphere we find good agreement with the reference data for the CO2 seasonal cycle and the CO2

  4. Cuidado ao idoso deprimido e institucionalizado à luz da Complexidade

    Directory of Open Access Journals (Sweden)

    Cenir Gonçalves Tier

    2008-06-01

    Full Text Available Instituições de Longa Permanência para Idosos (ILPI são estabelecimentos para atendimento integral, institucionalizando pessoas de 60 anos e mais, dependentes/ou não, que não dispõem de condições para permanecer com a família ou/em seu domicílio. A institucionalização pode desencadear doenças, dentre elas a depressão. Foi objetivo deste artigo de atualização fazer uma reflexão sobre a relação do cuidado ao idoso deprimido e residente em ILPI com três princípios da Complexidade segundo Edgar Morin. Primeiro, se reflete sobre a complexidade; depois, se relaciona o cuidado ao idoso deprimido e residente em ILPI, com os princípios dialógico, recursivo e hologramático. Percebeu-se que a Complexidade pode sustentar teoricamente, não só a compreensão do fenômeno depressão no idoso residente em uma ILPI, como também inspirar o modo de cuidar que direcione aos trabalhadores da saúde, que atuam junto à pessoa idosa, a abordarem o idoso de forma mais global. Para tanto deve ser utilizada a Avaliação Multidimensional do Idoso, que analisa as várias dimensões da pessoa idosa, contribuindo no desenvolvimento de um plano de cuidado/tratamento e acompanhamento multidisciplinar e interdisciplinar adequados. A Complexidade vem sendo utilizada, por enfermeiros, para entender melhor a enfermagem e prestar cuidado mais adequado ao ser humano.

  5. Resistência natural de nove madeiras do semi-árido brasileiro a fungos causadores da podridão-mole Natural resistance of nine woods of Brazilian semi-arid region to soft-rot fungi

    Directory of Open Access Journals (Sweden)

    Juarez Benigno Paes

    2005-06-01

    Full Text Available O objetivo desta pesquisa foi avaliar a resistência de nove madeiras de ocorrência no semi-árido brasileiro a fungos de podridão-mole, em condições de laboratório. As madeiras estudadas foram algaroba (Prosopis juliflora, angico (Anadenanthera colubrina var. cebil, aroeira (Myracrodruon urundeuva, braúna (Schinopsis brasiliensis, cássia (Senna siamea, craibeira (Tabebuia aurea, cumaru (Amburana cearensis, pau-d'arco (Tabebuia impetiginosa e pereiro (Aspidosperma pyrifolium. De cada espécie foram retirados corpos-de-prova de 3,0 x 1,5 x 0,5 cm, com a maior dimensão no sentido das fibras, em quatro posições na direção medula-casca do tronco. As amostras permaneceram por 120 dias sob a ação da microflora natural existente em solo orgânico. A resistência ao apodrecimento da aroeira, braúna e cássia não foi afetada pela posição na direção medula-casca, não esteve relacionada à densidade das madeiras ensaiadas. As madeiras de aroeira e braúna (cerne, pereiro e pau-d'arco apresentaram melhor desempenho. A resistência natural não esteve associada à concentração de extrativos solúveis em água quente.The objective of this research was to evaluate the wood natural resistance of nine species of woods of the Brazilian semi-arid region to soft-rot fungi, under laboratory conditions. The studied woods were Prosopis juliflora, Anadenanthera colubrinavar.cebil, Myracrodruon urundeuva, Schinopsis brasiliensis, Senna siamea, Tabebuia aurea, Amburana cearensis, Tabebuia impetiginosa and Aspidosperma pyrifolium. Specimens measuring 3.0 x 1.5 x 0.5 cm, with the largest dimension taken in the fiber direction, were obtained from four positions from pith to bark in the trunk. The specimens were submitted to action of organic soil natural micro-flora for 120 days. The wood resistance to soft-rot of Myracrodruon urundeuva, Schinopsis brasiliensis and Senna siameawas not affected by the pith to bark position, and was not associated to

  6. Resposta ao estresse: I. Homeostase e teoria da alostase

    Directory of Open Access Journals (Sweden)

    Maria Bernardete Cordeiro de Sousa

    2015-03-01

    Full Text Available ResumoOs seres vivos desenvolvem ao longo de sua história evolutiva mecanismos de enfrentamento às condições adversas originadas tanto no ambiente geofísico como no ambiente social. Esta resposta adaptativa é coordenada e envolve diferentes sistemas funcionais, particularmente, os sistemas nervoso, endócrino e imune, e é denominada de resposta ao estresse e deve atender a duas demandas principais da vida: sobrevivência e reprodução. Esta revisão tem o objetivo de discutir o emprego do conceito clássico de homeostase e um conceito alternativo, alostase, que inclui os mecanismos preditivos e reativos de regulação, assim como os diferentes níveis de impacto dos estressores crônicos, resultando em sobrecarga alostática que pode ou não se seguir de falha alostática. Os mecanismos neurais, hormonais, imunes, sistêmicos e moleculares, que compreendem os sistemas alóstaticos subjacentes à resposta ao estresse são também apresentados.

  7. LDEF results for polymer-matrix composite experiment AO 180

    International Nuclear Information System (INIS)

    This report represents a summary of the results obtained to-date on a polymer matrix composite experiment (AO 180) located at station D-12, about 82 deg off the 'ram' direction. Different material systems comprised of graphite, boron, and aramid (Kevlar) fiber reinforcements were studied. Although previous results were presented on in-situ thermal-vacuum cycling effects, particularly dimensional changes associated with outgassing, additional comparative data will be shown from ground-based tests on control and flight samples. The system employed was fully automated for thermal-vacuum cycling using a laser interferometer for monitoring displacements. Erosion of all three classes of materials due to atomic oxygen (AO) will also be discussed, including angle of incidence effects. Data from this experiment will be compared to published results for similar materials in other LDEF experiments. Composite materials' erosion yields will be presented on an AO design nomogram useful for estimating total material loss for given exposure conditions in low Earth orbit (LEO). Optical properties of these materials will also be compared with control samples. A survey of the damage caused by micrometeoroids/debris impacts will be addressed as they relate to polymer matrix composites. Correlations between hole size and damage pattern will be given. Reference to a new nomogram for estimating the number distribution of micrometeoroid/debris impacts for a given space structure as a function of time in LEO will be addressed based on LDEF data

  8. Laboratory demonstration of real time frame selection with Magellan AO

    Science.gov (United States)

    Males, Jared R.; Close, Laird M.; Kopon, Derek; Quiros-Pacheco, Fernando; Riccardi, Armando; Xompero, Marco; Puglisi, Alfio; Gasho, Victor; Morzinski, Katie M.; Follette, Katherine B.

    2012-07-01

    The Magellan AO system combines a pyramid wavefront sensor and high-order adaptive secondary mirror, and will see first light on the Magellan Clay telescope in November 2012. With a 24 cm projected actuator pitch, this powerful system will enable good correction in the optical (0.5 to 1 μm). Realistic laboratory testing has produced Strehl ratios greater than 40% in i’ (0.765 μm) on bright simulated stars. On fainter stars our visible AO camera, VisAO, will work in the partially corrected regime with only short moments of good correction. We have developed a form of lucky imaging, called real time frame selection, which uses a fast shutter to block moments of bad correction, and quickly opens the shutter when the correction is good, enabling long integrations on a conventional CCD while maximizing Strehl ratio and resolution. The decision to open or shut is currently based on reconstructed WFS telemetry. Here we report on our implementation and testing of this technique in the Arcetri test tower in Florence, Italy, where we showed that long exposure i’ Strehl could be improved from 16% to 26% when the selection threshold was set to the best 10% of instantaneous Strehl.

  9. Absence of Maternal Methylation in Biparental Hydatidiform Moles from Women with NLRP7 Maternal-Effect Mutations Reveals Widespread Placenta-Specific Imprinting

    Science.gov (United States)

    Sanchez-Delgado, Marta; Martin-Trujillo, Alejandro; Tayama, Chiharu; Vidal, Enrique; Esteller, Manel; Iglesias-Platas, Isabel; Deo, Nandita; Barney, Olivia; Maclean, Ken; Hata, Kenichiro; Nakabayashi, Kazuhiko; Fisher, Rosemary; Monk, David

    2015-01-01

    Familial recurrent hydatidiform mole (RHM) is a maternal-effect autosomal recessive disorder usually associated with mutations of the NLRP7 gene. It is characterized by HM with excessive trophoblastic proliferation, which mimics the appearance of androgenetic molar conceptuses despite their diploid biparental constitution. It has been proposed that the phenotypes of both types of mole are associated with aberrant genomic imprinting. However no systematic analyses for imprinting defects have been reported. Here, we present the genome-wide methylation profiles of both spontaneous androgenetic and biparental NLRP7 defective molar tissues. We observe total paternalization of all ubiquitous and placenta-specific differentially methylated regions (DMRs) in four androgenetic moles; namely gain of methylation at paternally methylated loci and absence of methylation at maternally methylated regions. The methylation defects observed in five RHM biopsies from NLRP7 defective patients are restricted to lack-of-methylation at maternal DMRs. Surprisingly RHMs from two sisters with the same missense mutations, as well as consecutive RHMs from one affected female show subtle allelic methylation differences, suggesting inter-RHM variation. These epigenotypes are consistent with NLRP7 being a maternal-effect gene and involved in imprint acquisition in the oocyte. In addition, bioinformatic screening of the resulting methylation datasets identified over sixty loci with methylation profiles consistent with imprinting in the placenta, of which we confirm 22 as novel maternally methylated loci. These observations strongly suggest that the molar phenotypes are due to defective placenta-specific imprinting and over-expression of paternally expressed transcripts, highlighting that maternal-effect mutations of NLRP7 are associated with the most severe form of multi-locus imprinting defects in humans. PMID:26544189

  10. Phase behaviour of pseudo-binary systems of pressurized ((propane + L,L-lactide)) at different ethanol to L,L-lactide mole ratios

    International Nuclear Information System (INIS)

    Highlights: • Phase equilibrium data of (propane + L,L-lactide) system at different ethanol to monomer mole ratios. • Static synthetic method from (323 to 353) K and pressures up to 3.3 MPa. • (Vapour + liquid) (VLE) was observed with bubble point (BP) type transitions. • Experimental modelled using the Peng–Robinson (PR) equation with the Wong–Sandler (PR–WS) rule. - Abstract: This work reports phase equilibrium data of pressurized (propane + L,L-lactide) system at different ethanol to monomer mole ratios (9:1; 7:1; 5:1). Phase equilibrium experiments were accomplished in a high-pressure variable-volume view cell employing the static synthetic method. (Vapour + liquid) equilibrium data for the pseudo-binary systems were determined within the temperature range from (323 to 353) K and pressures up to 3.3 MPa. For the systems investigated, (vapour + liquid) equilibrium (VLE) was visually recorded. It was observed that an increase in temperature or in propane concentration led to a pronounced rise in pressure transition values. On the other hand, an increase in the ethanol to L,L-lactide mole ratio led to a reduction in pressure transitions, whereas a reduction in ethanol concentration complicates the achievement of one-phase homogeneous system. Thus, rapid complete miscibility of the system can be controlled by the amount of ethanol added as a co-solvent. The experimental results were modelled using the Peng–Robinson (PR) equation of state with the Wong–Sandler (PR–WS) mixing rule, providing a good representation of the experimental phase transition points

  11. Long-term validation of tropospheric column-averaged CH4 mole fractions obtained by mid-infrared ground-based FTIR spectrometry

    OpenAIRE

    Blumenstock, T.; A. Gomez-Pelaez; Dohe, S.; O. E. García; Hase, F.; Schneider, M.; E. Sepúlveda; Guerra, J.C.

    2012-01-01

    At the Izaña Atmospheric Research Center, high-resolution mid-infrared solar absorption spectra have been recorded for more than 12 yr using Fourier Transform InfraRed (FTIR) spectrometers. We use the spectral fitting algorithm PROFFIT to retrieve long-term time series of methane (CH4) from the measured spectra. We investigate the total column-averaged dry air mole fractions of methane (totXCH4) obtained from a profile scaling and a profile retrieval, and apply two approaches for deriving the...

  12. Long-term validation of total and tropospheric column-averaged CH4 mole fractions obtained by mid-infrared ground-based FTIR spectrometry

    OpenAIRE

    Blumenstock, T.; A. Gomez-Pelaez; Dohe, S.; O. E. García; Hase, F.; Schneider, M.; E. Sepúlveda; Guerra, J.C.

    2012-01-01

    At the Izaña Atmospheric Research Center high-resolution middle infrared solar absorption spectra have been recorded for more than 12 years using Fourier Transform InfraRed (FTIR) spectrometers. We use the spectral fitting algorithm PROFFIT to retrieve long-term time series of methane (CH4) from the measured spectra. We investigate the total column-averaged dry-air mole fractions of methane (totXCH4) obtained from a scaling and a profile retrieval, and apply two approaches for deriving the tr...

  13. Hammering beneath the Surface of Mars - Analyse des Schlagzyklus und der äußeren Form des HP3-Mole mit Hilfe der Diskrete Elemente Methode

    OpenAIRE

    Lichtenheldt, Roy

    2015-01-01

    Die Marsmission „InSight“ (Interior Exploration using Seismic Investigations, Geodesy and Heat Transfer) der NASA hat das Ziel, Fragen zur Entstehung erdähnlicher Planeten zu beantworten. Dafür schlägt sich der HP3-Mole tiefer unter die Oberfläche des Mars als je ein anderes Instrument zuvor. Der Vortrieb dieses „selbsteinschlagenden Nagels“ hängt dabei stark vom Ablauf des inneren Schlagzyklus, der äußeren Formgebung des Mechanismus und der Interaktion mit dem umgebenden Regolith ab. Nach...

  14. Resposta de cultivares de arroz irrigado ao nitrogênio

    Directory of Open Access Journals (Sweden)

    Freitas José Guilherme de

    2001-01-01

    Full Text Available Genótipos de arroz irrigado por inundação (Oryza sativa L. podem apresentar variabilidade de resposta ao nitrogênio. O objetivo deste trabalho foi avaliar a resposta de três cultivares de arroz ao nitrogênio. Os experimentos foram realizados em Mococa, SP, em 1997/98 e 1998/99, em Cambissolo Háplico Tb Eutrófico gleico. O delineamento estatístico foi em blocos ao acaso, em esquema de parcelas subdivididas, com quatro repetições. Nas parcelas foram aplicadas doses de N (0, 50, 100 e 150 kg ha-1 e nas subparcelas foram transplantadas mudas dos cultivares de arroz (IAC 101, IAC 102 e IAC 104. O nitrogênio foi aplicado parceladamente sendo 1/3 da dose no transplantio das mudas, 1/3 aos 20 dias e 1/3 aos 40 dias, após o transplantio. Os cultivares responderam significativamente à aplicação de N e a média de produtividade de grãos dos três cultivares na maior dose de N foi superior a 8 t ha-1. Os cultivares IAC 104 e IAC 101 apresentaram maiores rendimentos de grãos (4863 e 5015 kg ha-1, na ausência da aplicação de N do que o IAC 102, com resposta quadrática para os dois primeiros e linear para o último. As doses adequadas de N foram 140 kg ha-1 para o 'IAC 101' e 150 kg ha-1 para 'IAC 102' e 'IAC 104'. O cultivar IAC 104 apresentou maior rendimento de grãos inteiros e, embora não tenha sido o mais produtivo nos dois anos do estudo, gerou maior produção de grãos inteiros por unidade de área. O comprimento da panícula foi o componente que melhor se correlacionou com o rendimento de grãos.

  15. Fatores associados a baixa adesao ao tratamento medicamentoso em idosos

    Directory of Open Access Journals (Sweden)

    Noemia Urruth Leao Tavares

    2013-12-01

    Full Text Available OBJETIVO : Analisar fatores associados à baixa adesão ao tratamento medicamentoso em idosos. MÉTODOS : Estudo transversal de base populacional, com amostra representativa de 1.593 indivíduos com 60 anos ou mais, residentes na região urbana de Bagé, RS, em 2008. A amostragem foi realizada em múltiplos estágios. Os dados foram coletados em entrevistas individuais nos domicílios. Analisou-se a associação entre a baixa adesão referida ao tratamento medicamentoso mensurado pelo Brief Medication Questionnaire (BMQ e fatores demográficos, socioeconômicos, comportamentais e de saúde, assistência e prescrição. Foi utilizado modelo de regressão de Poisson para estimar as razões de prevalência bruta e ajustada, os respectivos intervalos de confiança de 95% e p-valor (teste de Wald. RESULTADOS : Cerca de 78,0% dos indivíduos referiram ter usado algum medicamento nos sete dias precedentes à entrevista. Desses, cerca de 1 / 3 foram considerados com baixa adesão ao tratamento. Os fatores significativamente associados à baixa adesão foram: idade (65 a 74 anos, não ter plano de saúde, ter que comprar (totalmente ou em parte os seus medicamentos, ter três ou mais morbidades, possuir incapacidade instrumental para a vida diária e usar três ou mais medicamentos. CONCLUSÕES : A utilização elevada de medicamentos, decorrente da alta prevalência de doenças crônico-degenerativas em idosos, e o acesso ao tratamento devem ser considerados pelos profissionais de saúde para adoção de estratégias que visem diminuir a baixa adesão ao tratamento, aumentando a resolutividade terapêutica e a qualidade de vida desses pacientes.

  16. Suporte relacionado ao cuidado em saúde ao doente com aids: o modelo de comboio e a enfermagem

    Directory of Open Access Journals (Sweden)

    Edilene Aparecida Araújo da Silveira

    2011-06-01

    Full Text Available O presente estudo teve como objetivo conhecer a relação e a troca de suporte entre o doente com AIDS e pessoas à sua volta. O estudo está baseado no modelo de comboio das relações sociais que tem como uma de suas características a representação da rede em três círculos concêntricos. Os participantes eram pessoas que estavam internadas e que falaram sobre o suporte relacionado ao cuidado em saúde proporcionado por pessoas próximas, ou seja, que pertenciam ao círculo interno do comboio. A maioria dos participantes descreveu o círculo como sendo composto por no máximo cinco integrantes, sendo que pessoas da família foram as mais citadas. Os profissionais de saúde precisam conhecer o paciente e seu comboio, reconhecendo-os no contexto psicossocial e cultural de forma a favorecer a aceitação da soropositividade, mudanças no estilo de vida, ajuda nos cuidados de saúde e adesão ao tratamento.

  17. Status Update and Closed-Loop Performance of the Magellan Adaptive Optics VisAO Camera

    OpenAIRE

    Kopon, Derek; Close, Laird M.; Males, Jared; Gasho, Victor; Morzinski, Katie; Follette, Katherine

    2014-01-01

    We present laboratory results of the closed-loop performance of the Magellan Adaptive Optics (AO) Adaptive Secondary Mirror (ASM), pyramid wavefront sensor (PWFS), and VisAO visible adaptive optics camera. The Magellan AO system is a 585-actuator low-emissivity high-throughput system scheduled for first light on the 6.5 meter Magellan Clay telescope in November 2012. Using a dichroic beamsplitter near the telescope focal plane, the AO system will be able to simultaneously perform visible (500...

  18. Effects of KOH:ZnCl2 mole ratio on the phase formation, morphological and inhibitive properties of potassium zinc phosphate (PZP) pigments

    International Nuclear Information System (INIS)

    Graphical abstract: This figure illustrates the inhibition mechanism. The film precipitation on the anodic and cathodic regions of the metal surface causes a drop in dissolution rate of steel. - Highlights: • We synthesized the ZP pigments via coprecipitation method. • Effect of KOH:ZnCl2 on phase formation, morphology and inhibitive performance of pigment. • KOH:ZnCl2 ratio is effective on phase formation and morphology of ZP pigments. • KZn2H(PO4)2 phase showed superior corrosion inhibition behavior than KZnPO4. - Abstract: Different types of potassium zinc phosphate (PZP) pigments were synthesized by a co-precipitation method. The PZPs were obtained through changing KOH:ZnCl2 mole ratio. The chemical composition of the pigments was studied by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy (SEM). Then, the extracts of the PZPs were prepared in 3.5% (w/w) NaCl solution. The inhibitive performance of the pigments was investigated by polarization technique and SEM surface analysis through dipping mild steel panels in the pigment extracts for different immersion times. Results showed that changing ZnCl2/KOH mole ratio could influence formation of KZn2H(PO4)2 and KZnPO4 phases. It was known that the KZn2H(PO4)2 phase has a superior corrosion inhibition behavior in 3.5% NaCl solution than KZnPO4 phase

  19. Effect of Mole Percentage of Crosslinker of Silver-poly(N-isopropylacrylamide-co-acrylic acid Hybrid Microgels on Catalytic Reduction of Nitrobenzene

    Directory of Open Access Journals (Sweden)

    Zahoor H. FAROOQI

    2015-02-01

    Full Text Available Poly(N-isopropylacrylamide-co-acrylic acid microgels [P(NIPAM-co-AAc] with 2, 4, 6 and 8 mole percentage of N,N-methylene-bis-acrylamide were used as micro-reactors for the fabrication of Ag nanoparticles using the in situ reduction method. The pure and hybrid microgels were characterized by Fourier transform infrared and Ultraviolet-Visible spectroscopies. Silver-poly(N-isopropylacrylamide-co-acrylic acid hybrid microgels [Ag-P(NIPAM-co-AAc] with different crosslinker contents were used as catalysts for reduction of nitrobenzene (NB in aqueous medium in order to investigate the effect of crosslinker content on the value of apparent rate constant (kapp. 0.041, 0.146, 0.2388 and 0.255 min-1 were found as values of kapp for catalytic reduction of NB using hybrid microgels with 2, 4, 6 and 8 mole percentage of crosslinker, respectively. The effect of crosslinker feed content of hybrid microgels on catalytic activity for reduction of NB was compared to that of reduction of p-nitrophenol in aqueous medium.

  20. Effect of Cu2+/Al3+ mole ratio on structure of Cu-Al bimetallic nanoparticles prepared by radiation induced method

    International Nuclear Information System (INIS)

    Cu-Al bimetallic nanoparticles were synthesized by gamma irradiation technique in aqueous solutions containing metal chlorides as precursors, polyvinyl alcohol (PVA) as a capping agent, isopropanol as a radical scavenger, and distilled water as a solvent. The Cu-Al bimetallic nanoparticles were characterized by transmission electron microscopy (TEM), UV-visible absorption spectrometry, powder X-ray diffractometer (XRD), and Energy-dispersive X-ray spectroscopy (EDX). The TEM, XRD, EDX, and absorption analyses confirmed the formation of core-shell structure of Cu-Al bimetallic nanoparticles at lower Cu2+/Al3+ mole ratio, and the formation of Cu-Al alloy nanoparticles at higher Cu2+/Al3+ mole ratio. The TEM analysis for particle size and size distribution revealed that the average particle size of Cu-Al bimetallic nanoparticles decreased with the increase of absorbed dose. It may be explained due to the competition between nucleation and aggregation processes in the formation of metallic nanoparticles under irradiation. (orig.)

  1. How attractive is the girl next door? An assessment of spatial mate acquisition and paternity in the solitary Cape dune mole-rat, Bathyergus suillus.

    Directory of Open Access Journals (Sweden)

    Timothy C Bray

    Full Text Available Behavioural observations of reproduction and mate choice in wild fossorial rodents are extremely limited and consequently indirect methods are typically used to infer mating strategies. We use a combination of morphological, reproductive, spatial, and genetic data to investigate the reproductive strategy of a solitary endemic species, the Cape dune mole-rat Bathyergus suillus. These data provide the first account on the population dynamics of this species. Marked sexual dimorphism was apparent with males being both significantly larger and heavier than females. Of all females sampled 36% had previously reproduced and 12% were pregnant at the time of capture. Post-partum sex ratio was found to be significantly skewed in favour of females. The paternity of fifteen litters (n = 37 was calculated, with sires assigned to progeny using both categorical and full probability methods, and including a distance function. The maximum distance between progeny and a putative sire was determined as 2149 m with males moving between sub-populations. We suggest that above-ground movement should not be ignored in the consideration of mate acquisition behaviour of subterranean mammals. Estimated levels of multiple paternity were shown to be potentially as high as 26%, as determined using sibship and sire assignment methods. Such high levels of multiple paternity have not been found in other solitary mole-rat species. The data therefore suggest polyandry with no evidence as yet for polygyny.

  2. Effect of Cu{sup 2+}/Al{sup 3+} mole ratio on structure of Cu-Al bimetallic nanoparticles prepared by radiation induced method

    Energy Technology Data Exchange (ETDEWEB)

    Abedini, Alam; Larki, Farhad; Saion, Elias; Noroozi, Monir [Putra Malaysia Univ., Serdang, Selangor (Malaysia). Dept. of Physics

    2013-07-15

    Cu-Al bimetallic nanoparticles were synthesized by gamma irradiation technique in aqueous solutions containing metal chlorides as precursors, polyvinyl alcohol (PVA) as a capping agent, isopropanol as a radical scavenger, and distilled water as a solvent. The Cu-Al bimetallic nanoparticles were characterized by transmission electron microscopy (TEM), UV-visible absorption spectrometry, powder X-ray diffractometer (XRD), and Energy-dispersive X-ray spectroscopy (EDX). The TEM, XRD, EDX, and absorption analyses confirmed the formation of core-shell structure of Cu-Al bimetallic nanoparticles at lower Cu{sup 2+}/Al{sup 3+} mole ratio, and the formation of Cu-Al alloy nanoparticles at higher Cu{sup 2+}/Al{sup 3+} mole ratio. The TEM analysis for particle size and size distribution revealed that the average particle size of Cu-Al bimetallic nanoparticles decreased with the increase of absorbed dose. It may be explained due to the competition between nucleation and aggregation processes in the formation of metallic nanoparticles under irradiation. (orig.)

  3. Gestação gemelar de mola hidatiforme completa com feto vivo Twin pregnancy with complete hydatidiform mole and living fetus

    Directory of Open Access Journals (Sweden)

    Daniela Angerame Yela

    2011-04-01

    Full Text Available A gestação gemelar de uma mola hidatiforme completa coexistindo com um feto vivo é uma entidade rara. Os poucos casos descritos na literatura mostram que, em geral, esse tipo de gestação cursa com risco aumentado de aborto espontâneo, parto prematuro, morte fetal intraútero, sangramento, pré-eclâmpsia e doença trofoblástica persistente. Neste artigo, descreveremos o caso de uma primigesta de 20 anos de idade que apresentou uma gestação gemelar de feto vivo com mola completa, a qual transcorreu sem intercorrências e complicações e cujo diagnóstico diferencial com degeneração da placenta foi feito com anatomopatológico.Twin pregnancy with a complete hydatidiform mole and a living fetus is a rare entity. According to the few cases described in the literature, this kind of gestation commonly has higher risks of miscarriage, preterm delivery, intrauterine fetal death, bleeding, preeclampsia and persistent trophoblastic disease. This study reports the case of a 20 years old primiparous patient with complete hydatidiform mole and living fetus, whose pregnancy was successfully carried to term. The differential diagnosis with placental degeneration was reached through anatomopathological investigation.

  4. Three years of greenhouse gas column-averaged dry air mole fractions retrieved from satellite – Part 1: Carbon dioxide

    Directory of Open Access Journals (Sweden)

    O. Schneising

    2008-07-01

    Full Text Available Carbon dioxide (CO2 and methane (CH4 are the two most important anthropogenic greenhouse gases. SCIAMACHY on ENVISAT is the first satellite instrument whose measurements are sensitive to concentration changes of the two gases at all altitude levels down to the Earth's surface where the source/sink signals are largest. We have processed three years (2003–2005 of SCIAMACHY near-infrared nadir measurements to simultaneously retrieve vertical columns of CO2 (from the 1.58 μm absorption band, CH4 (1.66 μm and oxygen (O2 A-band at 0.76 μm using the scientific retrieval algorithm WFM-DOAS. We show that the latest version of WFM-DOAS, version 1.0, which is used for this study, has been significantly improved with respect to its accuracy compared to the previous versions while essentially maintaining its high processing speed (~1 min per orbit, corresponding to ~6000 single measurements, and per gas on a standard PC. The greenhouse gas columns are converted to dry air column-averaged mole fractions, denoted XCO2 (in ppm and XCH4 (in ppb, by dividing the greenhouse gas columns by simultaneously retrieved dry air columns. For XCO2 dry air columns are obtained from the retrieved O2 columns. For XCH4 dry air columns are obtained from the retrieved CO2 columns because of better cancellation of light path related errors compared to using O2 columns retrieved from the spectrally distant O2 A-band. Here we focus on a discussion of the XCO2 data set. The XCH4 data set is discussed in a separate paper (Part 2. In order to assess the quality of the retrieved XCO2 we present comparisons with Fourier Transform Spectroscopy (FTS XCO2 measurements at two northern hemispheric mid-latitude ground stations. To assess the quality globally, we present detailed comparisons with

  5. Integrando a retórica ao game design

    OpenAIRE

    Moroni, Leonardo Mendes

    2013-01-01

    Resumo: O potencial dos jogos eletrônicos como mídia que atinge camadas cada vez mais extensas da população, com reflexos sociais, culturais e econômicos, é evidente. No entanto, jogos que alcançam grande sucesso comercial objetivam, essencialmente, propiciar diversão aos seus usuários. Com base nesta premissa, tanto usuários quanto avaliadores desta mídia acabam por desconsiderar o potencial que os jogos oferecem em termos de veicular mensagens com conteúdo relevante para a vida real, como, ...

  6. Mudança organizacional : do prescrito ao real

    OpenAIRE

    Sinval, Jorge Fernando Pereira

    2011-01-01

    As organizações dos dias de hoje enfrentam um ambiente cada vez mais dinâmico e em constante mudança. Necessitam de adaptar-se aos novos desafios. Com as crescentes evoluções tecnológicas, que ocorrem em quase todos os sectores de atividade, a maior parte dos trabalhadores é confrontada, em algum momento do seu percurso profissional, com a introdução de mudanças no seu posto de trabalho, mudanças com as quais terão de lidar. A mudança organizacional influencia quer a empresa, quer o trabalhad...

  7. Impacto dos incentivos fiscais e parafiscais no apoio ao emprego

    OpenAIRE

    Ferreira, Licínia Isabel dos Santos

    2011-01-01

    A presente investigação tem como objectivo analisar “o impacto dos incentivos fiscais e parafiscais no apoio ao emprego”; identificar os “incentivos ficais e as isenções no âmbito do apoio às empresas” , assim como verificar os seus “reflexos na contratação de trabalhadores”. Para tal, tentou-se perceber quais as políticas e legislação que estão subjacentes a estes incentivos e de que forma se colocam em prática, fomentando a contratação dos trabalhadores. A metodologia a...

  8. da prevenção aos cuidados paliativos

    OpenAIRE

    Nogueira, Ana Rita Cardoso

    2013-01-01

    Objetivo: Efetuar uma revisão tradicional da literatura sobre o papel que a alimentação/nutrição tem, quer na prevenção quer na progressão da demência incluindo a fase final da vida. Metodologia: Foi realizada pesquisa bibliográfica no PubMed e na B-On, entre fevereiro e julho de 2013, que abarcou todas as publicações relativas aos últimos 5 anos. Utilizaram-se, para isso, as seguintes palavras-chave “palliative care AND dementia” e “nutrition AND dementia”. Resultados: As vitaminas dos...

  9. Titanium alloys (AoN) and their involvement in osseointegration

    OpenAIRE

    Matteo Danza; Ilaria Zollino; Valentina Candotto; Francesca Cura; Francesco Carinci

    2012-01-01

    Background: Osseointegration is essential for a long-term successful and inflammation-free dental implant. Such a result depends on osteoblastic cells growth and differentiation at the tissue-implant interface. The aim of this study was to compare two different AoN titanium layers (GR4 and GR5) to investigate which one had a greater osteoconductive power using human osteoblasts (HOb) culture at two different time-points. Materials and Methods: The expression levels of some bone-related (A...

  10. Alternativas de controle pós-colheita da podridão-parda e da podridão-mole em frutos de pessegueiro Alternatives for post-harvest control of brown rot and soft rot in peach fruits

    Directory of Open Access Journals (Sweden)

    Vicente Luiz de Carvalho

    2009-03-01

    Full Text Available As exigências do consumidor são cada vez maiores com relação à qualidade de produtos in natura. As podridões, além de causar perdas na produção, reduzem a qualidade final do fruto, interferindo significativamente na comercialização. Objetivou-se, com este trabalho, avaliar a eficiência de produtos alternativos, aplicados na pós-colheita, no controle da podridão-parda (Monilinia fructicola e da podridão-mole (Rhizopus spp. em pêssegos. O experimento foi conduzido no município de Nepomuceno-MG, em talhão de pessegueiro da cultivar Diamante, com 10 anos de idade. O delineamento experimental utilizado foi o inteiramente casualizado, com 7 tratamentos e 3 repetições. Para o estudo, foram selecionados frutos sem lesões e sem sintomas das doenças. Os frutos foram mergulhados por 30 segundos em solução contendo os seguintes tratamentos: 1-Óleo de cravo 0,01%; 2-Dióxido de cloro 0,1%; 3-Dióxido de cloro 0,05%; 4-Cloreto de benzalcônio 0,25%; 5-Dicloran 0,12%; 6-Iprodione 0,15% e 7-Testemunha (somente água. Após os tratamentos, os frutos, em número de 10, foram colocados em bandejas esterilizadas, em três repetições. O experimento foi conduzido em condições de ambiente não controlado, sendo feitas avaliações do desenvolvimento das doenças aos 3 e aos 5 dias após os tratamentos em 2005 e aos 3; 6 e aos 9 dias após o tratamento em 2006. O iprodione controlou a incidência e a severidade de M. fructicola e Rhizopus spp. O dicloran foi o tratamento mais eficiente para o controle do Rhizopus spp. e intermediário para M. fructicola. Os tratamentos com óleo de cravo e dióxido de cloro, na maior dose, reduziram a incidência de Rhizopus spp. e para severidade apresentaram resultados intermediários.The consumers demand are increasing with regard to the quality of in nature products. The rot, besides causing loss in production, reduce the quality of the product, interfering significantly in the marketing. The objective

  11. Dicty_cDB: FC-AO01 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available 3 AY961548_1( AY961548 |pid:none) Lysiphlebus testaceipes ribosomal ... 210 2e-53 AP003943_18( AP003943 |pid...FC-AO01Z (Link to Original site) Representative DNA sequence >FC-AO01 (FC-AO01Q) /CSM/FC/FC-AO/FC-AO01Q.Seq..... 48 5e-11 3 dna update 2003. 7.11 Homology vs Protein Score E Sequences producing significant alignments: (bit...nk to dictyBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U15674-1 Original site URL http:/...FC (Link to library) FC-AO01 (Link to dictyBase) - - - Contig-U15674-1 FC-AO01Z (Link to Original site

  12. Analysis of CO2 mole fraction data: first evidence of large-scale changes in CO2 uptake at high northern latitudes

    Science.gov (United States)

    Barlow, J. M.; Palmer, P. I.; Bruhwiler, L. M.; Tans, P.

    2015-12-01

    Atmospheric variations of carbon dioxide (CO2) mole fraction reflect changes in atmospheric transport and regional patterns of surface emission and uptake. Here we present a study of changes in the observed high northern latitude CO2 seasonal cycle. We report new estimates for changes in the phase and amplitude of the seasonal variations, indicative of biospheric changes, by spectrally decomposing multi-decadal records of surface CO2 mole fraction using a wavelet transform to isolate the changes in the observed seasonal cycle. We also perform similar analysis of the first derivative of CO2 mole fraction, ΔtCO2, that is a crude proxy for changes in CO2 flux. Using numerical experiments, we quantify the aliasing error associated with independently identifying trends in phase and peak uptake and release to be 10-25 %, with the smallest biases in phase associated with the analysis of ΔtCO2. We report our analysis from Barrow, Alaska (BRW), during 1973-2013, which is representative of the broader Arctic region. We determine an amplitude trend of 0.09 ± 0.02 ppm yr-1, which is consistent with previous work. Using ΔtCO2 we determine estimates for the timing of the onset of net uptake and release of CO2 of -0.14 ± 0.14 and -0.25 ± 0.08 days yr-1 respectively and a corresponding net uptake period of -0.11 ± 0.16 days yr-1, which are significantly different to previously reported estimates. We find that the wavelet transform method has significant skill in characterizing changes in the peak uptake and release. We find a trend of 0.65 ± 0.34 % yr-1 (p < 0.01) and 0.42 ± 0.34 % yr-1 (p < 0.05) for rates of peak uptake and release respectively. Our analysis does not provide direct evidence about the balance between uptake and release of carbon when integrated throughout the year, but the increase in the seasonal amplitude of CO2 together with an invariant net carbon uptake period provides evidence that high northern latitude ecosystems are progressively taking up more

  13. Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat.

    Science.gov (United States)

    Triplett, Judy C; Swomley, Aaron M; Kirk, Jessime; Grimes, Kelly M; Lewis, Kaitilyn N; Orr, Miranda E; Rodriguez, Karl A; Cai, Jian; Klein, Jon B; Buffenstein, Rochelle; Butterfield, D Allan

    2016-07-01

    Aging is the greatest risk factor for developing neurodegenerative diseases, which are associated with diminished neurotransmission as well as neuronal structure and function. However, several traits seemingly evolved to avert or delay age-related deterioration in the brain of the longest-lived rodent, the naked mole-rat (NMR). The NMR remarkably also exhibits negligible senescence, maintaining an extended healthspan for ~75 % of its life span. Using a proteomic approach, statistically significant changes with age in expression and/or phosphorylation levels of proteins associated with neurite outgrowth and neurotransmission were identified in the brain of the NMR and include: cofilin-1; collapsin response mediator protein 2; actin depolymerizing factor; spectrin alpha chain; septin-7; syntaxin-binding protein 1; synapsin-2 isoform IIB; and dynamin 1. We hypothesize that such changes may contribute to the extended lifespan and healthspan of the NMR. PMID:26935741

  14. Assessing Animal Welfare Impacts in the Management of European Rabbits (Oryctolagus cuniculus, European Moles (Talpa europaea and Carrion Crows (Corvus corone.

    Directory of Open Access Journals (Sweden)

    Sandra E Baker

    Full Text Available Human-wildlife conflict is a global issue. Attempts to manage this conflict impact upon wild animal welfare, an issue receiving little attention until relatively recently. Where human activities harm animal welfare these effects should be minimised where possible. However, little is known about the welfare impacts of different wildlife management interventions, and opinions on impacts vary widely. Welfare impacts therefore need to be assessed objectively. Our objectives were to: 1 establish whether an existing welfare assessment model could differentiate and rank the impacts of different wildlife management interventions (for decision-making purposes; 2 identify and evaluate any additional benefits of making formal welfare assessments; and 3 illustrate issues raised by application of the model. We applied the welfare assessment model to interventions commonly used with rabbits (Oryctolagus cuniculus, moles (Talpa europaea and crows (Corvus corone in the UK. The model ranked interventions for rabbits (least impact first: fencing, head shot, chest shot and crows (shooting, scaring, live trapping with cervical dislocation. For moles, managing molehills and tunnels scored least impact. Both spring trapping, and live trapping followed by translocation, scored greater impacts, but these could not be compared directly as they scored on different axes of the model. Some rankings appeared counter-intuitive, highlighting the need for objective formal welfare assessments. As well as ranking the humaneness of interventions, the model highlighted future research needs and how Standard Operating Procedures might be improved. The model is a milestone in assessing wildlife management welfare impacts, but our research revealed some limitations of the model and we discuss likely challenges in resolving these. In future, the model might be developed to improve its utility, e.g. by refining the time-scales. It might also be used to reach consensus among

  15. Assessing Animal Welfare Impacts in the Management of European Rabbits (Oryctolagus cuniculus), European Moles (Talpa europaea) and Carrion Crows (Corvus corone).

    Science.gov (United States)

    Baker, Sandra E; Sharp, Trudy M; Macdonald, David W

    2016-01-01

    Human-wildlife conflict is a global issue. Attempts to manage this conflict impact upon wild animal welfare, an issue receiving little attention until relatively recently. Where human activities harm animal welfare these effects should be minimised where possible. However, little is known about the welfare impacts of different wildlife management interventions, and opinions on impacts vary widely. Welfare impacts therefore need to be assessed objectively. Our objectives were to: 1) establish whether an existing welfare assessment model could differentiate and rank the impacts of different wildlife management interventions (for decision-making purposes); 2) identify and evaluate any additional benefits of making formal welfare assessments; and 3) illustrate issues raised by application of the model. We applied the welfare assessment model to interventions commonly used with rabbits (Oryctolagus cuniculus), moles (Talpa europaea) and crows (Corvus corone) in the UK. The model ranked interventions for rabbits (least impact first: fencing, head shot, chest shot) and crows (shooting, scaring, live trapping with cervical dislocation). For moles, managing molehills and tunnels scored least impact. Both spring trapping, and live trapping followed by translocation, scored greater impacts, but these could not be compared directly as they scored on different axes of the model. Some rankings appeared counter-intuitive, highlighting the need for objective formal welfare assessments. As well as ranking the humaneness of interventions, the model highlighted future research needs and how Standard Operating Procedures might be improved. The model is a milestone in assessing wildlife management welfare impacts, but our research revealed some limitations of the model and we discuss likely challenges in resolving these. In future, the model might be developed to improve its utility, e.g. by refining the time-scales. It might also be used to reach consensus among stakeholders about

  16. Effects of KOH:ZnCl{sub 2} mole ratio on the phase formation, morphological and inhibitive properties of potassium zinc phosphate (PZP) pigments

    Energy Technology Data Exchange (ETDEWEB)

    Askari, F. [Inorganic Pigment and Glazes Department, Institute for Color Science and Technology, Tehran 1668814811 (Iran, Islamic Republic of); Surface Coatings and Corrosion Department, Institute for Color Science and Technology, Tehran 1668814811 (Iran, Islamic Republic of); Ghasemi, E., E-mail: eghasemi@iust.ac.ir [Inorganic Pigment and Glazes Department, Institute for Color Science and Technology, Tehran 1668814811 (Iran, Islamic Republic of); Ramezanzadeh, B.; Mahdavian, M. [Surface Coatings and Corrosion Department, Institute for Color Science and Technology, Tehran 1668814811 (Iran, Islamic Republic of)

    2015-05-15

    Graphical abstract: This figure illustrates the inhibition mechanism. The film precipitation on the anodic and cathodic regions of the metal surface causes a drop in dissolution rate of steel. - Highlights: • We synthesized the ZP pigments via coprecipitation method. • Effect of KOH:ZnCl{sub 2} on phase formation, morphology and inhibitive performance of pigment. • KOH:ZnCl{sub 2} ratio is effective on phase formation and morphology of ZP pigments. • KZn{sub 2}H(PO{sub 4}){sub 2} phase showed superior corrosion inhibition behavior than KZnPO{sub 4}. - Abstract: Different types of potassium zinc phosphate (PZP) pigments were synthesized by a co-precipitation method. The PZPs were obtained through changing KOH:ZnCl{sub 2} mole ratio. The chemical composition of the pigments was studied by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy (SEM). Then, the extracts of the PZPs were prepared in 3.5% (w/w) NaCl solution. The inhibitive performance of the pigments was investigated by polarization technique and SEM surface analysis through dipping mild steel panels in the pigment extracts for different immersion times. Results showed that changing ZnCl{sub 2}/KOH mole ratio could influence formation of KZn{sub 2}H(PO{sub 4}){sub 2} and KZnPO{sub 4} phases. It was known that the KZn{sub 2}H(PO{sub 4}){sub 2} phase has a superior corrosion inhibition behavior in 3.5% NaCl solution than KZnPO{sub 4} phase.

  17. Arquitectura de peso. Do monumento ao (anti)monumento

    OpenAIRE

    Eva Patrícia da Silva Rocha Florindo

    2012-01-01

    Este ensaio reflecte sobre as raízes do conceito de monumento e a sua evolução ao longo dos tempos como forma de dar resposta à questão o que é quot;ser monumento hoje? A pertinência do tema fundamenta-se no paradoxo que acompanha a actual existência do monumento: embora continue muito presente na nossa sociedade é comummente negada a sua edificação, sendo-lhe atribuídas outras designações, como a de quot;ícone arquitectónico.Pretende-se assim desfazer o conflito moral que tem perseguido este...

  18. Correla\\c{c}\\~ao de longa-dura\\c{c}\\~ao e anal\\'ise bayesiana da evolu\\c{c}\\~ao temporal dos terremotos ao longo da falha de samambaia, nordeste do brasil

    CERN Document Server

    de Freitas, D B; Pereira, L L S; Pedro, L S; Atanazio, M G N; Vilar, C S

    2013-01-01

    A Bayesian approach is adopted to analyze the sequence of seismic events and their magnitudes near Jo\\~ao C\\^amara which occurred mainly from 1983 to 1998 along the Samambaia fault. In this work, we choose a Bayesian model for the process of occurrence times conditional on the observed magnitude values following the same procedure suggested by Stavrakakis and Tselentis (1987). The model parameters are determined on the basis of historical and physical information. We generate posterior samples from the joint posterior distribution of the model parameters by using a variant of the Metropolis-Hastings algorithm. We use the results in a variety of ways, including the construction of pointwise posterior confidence bands for the conditional intensity of the point process as a function of time, as well as, a posterior distribuition as a function of the mean of occurrence per unit time.

  19. Virtópsia: o adeus ao bisturi?

    OpenAIRE

    Andrade, Sílvia da Luz Meneses Duarte de

    2015-01-01

    A investigação médico-legal atual tem cada vez mais ao seu dispor técnicas radiológicas que visam auxiliar o diagnóstico da causa de morte e mecanismos fisiopatológicos determinantes da mesma. Contudo, a dúvida levantada pela utilização desses métodos é se estes poderiam vir a ser substitutos da autópsia convencional, ou se apenas têm capacidade de ser implementados como adjuntos da mesma. Nesta revisão tentou-se focar os pontos a favor e contra de algumas das técnicas utilizadas, nomeadament...

  20. Cuidado ao idoso deprimido e institucionalizado à luz da Complexidade

    OpenAIRE

    Cenir Gonçalves Tier; Valéria Lerch Lunardi; Silvana Sidney Costa Santos

    2008-01-01

    Instituições de Longa Permanência para Idosos (ILPI) são estabelecimentos para atendimento integral, institucionalizando pessoas de 60 anos e mais, dependentes/ou não, que não dispõem de condições para permanecer com a família ou/em seu domicílio. A institucionalização pode desencadear doenças, dentre elas a depressão. Foi objetivo deste artigo de atualização fazer uma reflexão sobre a relação do cuidado ao idoso deprimido e residente em ILPI com três princípios da Complexidade segundo Edgar ...

  1. Há alternativas ao uso dos transgênicos?

    OpenAIRE

    Hugh Lacey

    2007-01-01

    A existência ou não de alternativa ao uso de transgênicos capaz de satisfazer a demanda mundial por alimento e nutrientes é uma questão que permanece aberta à investigação científica. A importância dos transgênicos ainda não está bem fundamentada no conhecimento científico disponível, em parte porque as conquistas e o potencial da agroecologia não foram objeto de atenção científica suficiente.Whether or not there are alternatives to using transgenics, that would be able to satisfy the world's...

  2. Os ditongos do latim ao português

    Directory of Open Access Journals (Sweden)

    Quednau, Laura Rosane

    2005-01-01

    Full Text Available O presente trabalho trata da evolução dos ditongos já existentes e do surgimento de novos ditongos do latim ao português, analisando a motivação de sua redução quando esta ocorre. Para tanto, apresentamos cada ditongo separadamente, trazendo informações sobre a sua forma em latim clássico, latim vulgar e português. Além disso, tratamos de outros processos de formação de ditongos em português, uma vez que o português possui um número maior de ditongos do que o latim. Por fim, apresentamos um quadro-resumo, sintetizando as informações mais importantes do trbalho: quais ditongos permaneceram, quais foram reduzidos, quais surgiram por outros processos e quais são as causas da formação de ditongos em português

  3. Introdução ao LaTeX

    Directory of Open Access Journals (Sweden)

    Eric Batista Ferreira

    2012-12-01

    Full Text Available O pacote de macros para o processamento de textos, LaTeX{}, que utiliza o TeX{} como principal ferramenta, é fundamental para a produção de textos matemáticos e científicos de alto nível e emph{layout} profissional. A necessidade de conhecê-los se torna ainda mais real para profissionais e estudantes das Ciências Exatas. Além de adequado para a notação Matemática, o LaTeX{} tem muitas outras vantagens, como ser gratuito, multiplataforma e livre de vírus. Por esses e outros motivos, o minicurso ``Introdução ao LaTeX{}'' foi ministrado na emph{I Semana da Matemática da Unifal-MG}, a convite de sua comissão organizadora.

  4. Há alternativas ao uso dos transgênicos?

    Directory of Open Access Journals (Sweden)

    Hugh Lacey

    2007-07-01

    Full Text Available A existência ou não de alternativa ao uso de transgênicos capaz de satisfazer a demanda mundial por alimento e nutrientes é uma questão que permanece aberta à investigação científica. A importância dos transgênicos ainda não está bem fundamentada no conhecimento científico disponível, em parte porque as conquistas e o potencial da agroecologia não foram objeto de atenção científica suficiente.Whether or not there are alternatives to using transgenics, that would be able to satisfy the world's food and nutrition needs, remains open to further scientific investigation. The necessity for using transgenics is not currently well based on available scientific knowledge, in part because the achievements and potential of agroecology have received insufficient scientific attention.

  5. NFIRAOS First Facility AO System for the Thirty Meter Telescope

    CERN Document Server

    Herriot, Glen; Atwood, Jenny; Boyer, Corinne; Byrnes, Peter; Caputa, Kris; Ellerbroek, Brent; Gilles, Luc; Hill, Alexis; Ljusic, Zoran; Pazder, John; Rosensteiner, Matthias; Smith, Malcolm; Spano, Paolo; Szeto, Kei; Véran, Jean-Pierre; Wevers, Ivan; Wang, Lianqi; Wooff, Robert

    2014-01-01

    NFIRAOS, the Thirty Meter Telescope's first adaptive optics system is an order 60x60 Multi-Conjugate AO system with two deformable mirrors. Although most observing will use 6 laser guide stars, it also has an NGS-only mode. Uniquely, NFIRAOS is cooled to -30 C to reduce thermal background. NFIRAOS delivers a 2-arcminute beam to three client instruments, and relies on up to three IR WFSs in each instrument. We present recent work including: robust automated acquisition on these IR WFSs; trade-off studies for a common-size of deformable mirror; real-time computing architectures; simplified designs for high-order NGS-mode wavefront sensing; modest upgrade concepts for high-contrast imaging.

  6. Lévi-Strauss nos 90 voltas ao passado

    Directory of Open Access Journals (Sweden)

    Lévi-Strauss Claude

    1998-01-01

    Full Text Available Este artigo responde às críticas formuladas por Christian Delacampagne e Bernard Traimond em "A Polêmica Sartre/Lévi-Strauss Revisitada. Nas Raízes das Ciências Sociais de Hoje", publicado em Les Temps Modernes 596 (novembro-dezembro de 1997. Para fazê-lo, recorda inicialmente o caráter relativo da oposição entre "sociedades frias" e "sociedades quentes". Em seguida, refuta a tese de que Maurice Merleau-Ponty, sob a capa de um elogio, teria dirigido críticas veladas ao autor. Finalmente, reconhecendo o afastamento da antropologia de hoje em face das posições do autor, admite, sem se pronunciar sobre o valor desse movimento, que temas de ar sartriano ressurgem nos antropólogos contemporâneos.

  7. Tamanho de amostras para quantificação da podridão-mole da alface e da couve-chinesa Sample size for assessment of soft rot in lettuce and Chinese cabbage

    OpenAIRE

    Adriano Márcio Freire Silva; Sami Jorge Michereff; Rosa de Lima Ramos Mariano; Alessandro José da Silva

    2008-01-01

    Os cultivos de alface e couve-chinesa podem ter a produção reduzida devido à ocorrência da podridão-mole, causada por Pectobacterium carotovorum subsp. carotovorum. O objetivo deste estudo foi determinar os tamanhos ideais das amostras para quantificação da incidência dessa doença em levantamentos no campo. Foram realizadas amostragens da incidência da podridão-mole em oito áreas de plantio de alface e cinco de couve-chinesa, situadas nos principais municípios produtores do Estado de Pernambu...

  8. DESCRIÇÃO ANATÔMICA DO LENHO DE Melaleuca leucadendron (L. L

    Directory of Open Access Journals (Sweden)

    Linéia Roberta Zen

    2016-03-01

    Full Text Available This work aimed the anatomical description of Melaleuca leucadendron wooden. The study was conducted from an individual tree collecting three discs for confection of histological slides and macerated. Was used to mashing nitricacetic method and for histology was used simple staining with 1% safranin. The wood anatomy agrees in general aspects to the typical pattern of Myrtaceae Family: flocking diffuse porosity, solitary pores, simple perforation plates, besides paratracheal axial parenchyma linear aliforme, very numerous rays and heterocellular, pits-ray vascular parenchyma-vascular and fibrous tissue composed of prominent fibrotraqueoids, very short fibers, distinct growth rings of walls marked by the end of the fibers flattened latewood. Qualitatively and quantitatively the wood did not reveal expressive characteristic, thus can be characterized by presenting a relatively simple anatomical structure, agreeing in general lines to Myrtaceae family.

  9. Cirurgia conservadora, radioterapia externa e reforço de dose com braquiterapia de alta taxa de dose: uma nova perspectiva no tratamento de sarcomas de partes moles do adulto Limb-sparing surgery, external beam radiotherapy and boost with high-dose rate brachytherapy: a new perspective for the treatment of soft tissue sarcomas in adults

    Directory of Open Access Journals (Sweden)

    Antonio Cássio Assis Pellizzon

    2002-03-01

    Full Text Available OBJETIVO: Avaliar a influência no controle local de pacientes adultos e portadores de sarcoma de partes moles em extremidades e submetidos a cirurgia conservadora do membro, com braquiterapia de alta taxa de dose (BATD como reforço para a radioterapia externa (RT. MATERIAL E MÉTODOS: Foram avaliados 16 pacientes tratados, de 1993 até 1999. A RT foi utilizada com finalidade pré ou pós-operatória (30--55 Gy e BATD com dose de 18--36 Gy (fx 3--6 Gy BID. Com base no modelo linear quadrático calculou-se a dose efetiva biológica ("biological effective dose" - BED para o tumor e comparou-se seu valor a dados da literatura internacional, que utiliza tratamentos com RT e braquiterapia de baixa taxa de dose (BBTD. RESULTADOS: Os valores médios e medianos da BED para os sarcomas de partes moles foram de 78,5 Gy7 e 80 Gy7. A análise univariada mostrou que a BED para o tumor, quando utilizada BATD, era semelhante ao valor de 83 Gy7 quando utilizada BBTD (p = 0,008. As taxas de controle local, sobrevida livre de doença e sobrevida global atuarial em cinco anos foram de 83,2%, 75% e 93,7%, respectivamente. CONCLUSÕES: A BATD, quando utilizada como método complementar no reforço de dose da RT no tratamento conservador dos sarcomas de partes moles, apresenta taxas de controle local equiparáveis às da literatura internacional; no entanto, estudos com número maior de pacientes e período maior de seguimento são ainda necessários para determinar o verdadeiro potencial da BATD em substituir a BBTD.PURPOSE: To evaluate the influence on local control in adult patients with soft tissue sarcomas of the limbs that underwent limb-sparing surgery and high-dose rate brachytherapy (HDRB in association with teletherapy. MATERIAL AND METHODS: Sixteen patients treated from 1993 to 1999 were reviewed. Teletherapy was used pre- or postoperatively (30--55 Gy in association with HDRB in a dose range of 18--36 Gy (fx 3--6 Gy BID. The linear quadratic model was

  10. Uso de antibióticos e leveduras para controle da podridão-mole em couve-chinesa Use of antibiotics and yeasts for controlling Chinese cabbage soft rot

    Directory of Open Access Journals (Sweden)

    MRF Mello

    2011-03-01

    Full Text Available A podridão-mole causada por Pectobacterium carotovorum subsp. carotovorum (Pcc pode ocorrer em plantios de couve-chinesa (Brassica pekinensis com até 67% de incidência. O trabalho visou avaliar a sensibilidade in vitro de Pcc a bactericidas, o efeito de Mycoshield® nas dosagens de 3,0 e 1,5 g L-1, e de leveduras a 10(8 cel/mL no controle da doença em casa de vegetação e em campo. As plantas foram pulverizadas com Mycoshield® (oxitetraciclina 20% e leveduras (Rh1 e Rh2 (Rhodotorula spp. e Sc1 (Saccharomyces cerevisae sete dias após o transplante, e inoculadas por picada com o isolado Pcc120, sete dias e 12 h após o tratamento, respectivamente. Em todos os experimentos foram avaliados os componentes epidemiológicos da doença. In vitro, 40 isolados de Pcc testados apresentaram resistência ao sulfato de cobre e sensibilidade a oxitetraciclina, estreptomicina, oxitetraciclina+estreptomicina e oxitetraciclina+sulfato de cobre, todos na concentração de 0,2 g L-1. Seis isolados de Pcc foram mais inibidos por Mycoshield® do que por Agri-Micina® (oxitetraciclina 1,5% + estreptomicina 15% ambos a 3,0 g L-1, não sendo inibidos por Kasumin® (casugamicina 2% (2,0 mL L-1. Em casa de vegetação, Mycoshield® (3,0 g L-1 reduziu a severidade e o índice de doença em até 47,4 e 19%; já a levedura Sc1 reduziu a severidade da doença e a área abaixo da curva de progresso da doença (AACPD em até 27,6 e 39,3%, respectivamente, enquanto Rh1 reduziu a AACPD em até 33,5%. Em campo, Mycoshield® reduziu o índice de doença (14,4% a severidade (15,5% e a AACPD (28,9%; enquanto que Rh1 reduziu o índice de doença (8,8% e Sc1 reduziu a AACPD (15,7%. Conclui-se que o Mycoshield® e as leveduras apresentaram baixa eficiência para controle da podridão-mole da couve-chinesa em campo.The soft rot caused by Pectobacterium carotovorum subsp. carotovorum (Pcc may occur in Chinese cabbage (Brassica pekinensis plantations presenting till 67% of incidence

  11. Robo-AO KP: A new era in robotic adaptive optics

    Science.gov (United States)

    Riddle, Reed L.; Baranec, Christoph; Law, Nicholas M.; Kulkarni, Shrinivas R.; Duev, Dmitry; Ziegler, Carl; Jensen-Clem, Rebecca M.; Atkinson, Dani Eleanor; Tanner, Angelle M.; Zhang, Celia; Ray, Amy

    2016-01-01

    Robo-AO is the first and only fully automated adaptive optics laser guide star AO instrument. It was developed as an instrument for 1-3m robotic telescopes, in order to take advantage of their availability to pursue large survey programs and target of opportunity observations that aren't possible with other AO systems. Robo-AO is currently the most efficient AO system in existence, and it can achieve an observation rate of 20+ science targets per hour. In more than three years of operations at Palomar Observatory, it has been quite successful, producing technology that is being adapted by other AO systems and robotic telescope projects, as well as several high impact scientific publications. Now, Robo-AO has been selected to take over operation of the Kitt Peak National Observatory 2.1m telescope. This will give Robo-AO KP the opportunity to pursue multiple science programs consisting of several thousand targets each during the three years it will be on the telescope. One-sixth of the observing time will be allocated to the US community through the NOAO TAC process. This presentation will discuss the process adapting Robo-AO to the KPNO 2.1m telescope, the plans for integration and initial operations, and the science operations and programs to be pursued.

  12. Adesão de pessoas com diabetes mellitus tipo 2 ao tratamento medicamentoso

    OpenAIRE

    2014-01-01

    Estudo seccional de abordagem quantitativa que objetivou avaliar a adesão ao tratamento medicamentoso entre pessoas com diabetes mellitus, e sua relação com variáveis clínicas, de tratamento e controle metabólico. A amostra constituiu-se de 162 pessoas com diabetes mellitus tipo 2 em seguimento ambulatorial. Para a coleta dos dados, foram utilizadas a Medida de Adesão aos Tratamentos e a consulta aos prontuários dos participantes. Obteve-se elevada adesão ao tratamento medicamentoso. Para um ...

  13. Complicações infecciosas relacionadas ao uso do cateter de Hickman

    OpenAIRE

    Costa, Andréa Monastier

    2012-01-01

    Resumo: o cateter de Hickman é um dispositivo frequentemente utilizado nos cuidados aos pacientes hospitalizados, particularmente os mais graves. No entanto, seu uso predispõe ao desenvolvimento de infecções locais ou sistêmicas, as quais implicam em riscos significativos ao indivíduo, aumentando os índices de morbidade, mortalidade, bem como nos custos hospitalares e no tempo de internação. Objetivos: analisar as complicações infecciosas relacionadas ao uso do cateter de Hickman, relacionar ...

  14. Tratamento pós-colheita com cálcio e microrganismos para controle da podridão-mole em tomate Postharvest treatments with calcium and microorganisms to control soft rot in tomato

    Directory of Open Access Journals (Sweden)

    Andréa M.A. Gomes

    2005-03-01

    Full Text Available Visando o controle da podridão-mole causada por Pectobacterium carotovorum subsp. carotovorum (Pcc em tomate, foram avaliadas três fontes de cálcio [CaCl2, Ca (CO32 e Ca (SO42], nas concentrações de 1; 2; 4; 6; e 8% (p/v, aplicadas pelo método de infiltração a vácuo. A inoculação do patógeno foi realizada 24 horas após o tratamento com cálcio, pela deposição de 10 ml de uma suspensão bacteriana com concentração de 10(8 UFC/ml, sobre ferimentos artificiais nos frutos tratados. A incubação foi feita em câmara úmida (umidade relativa de 92±4% e a avaliação realizada 48 h após, medindo-se o diâmetro da lesão em sentidos diametralmente opostos, e calculando-se a porcentagem de redução da severidade da doença (RSD em relação à testemunha. A melhor fonte e concentração de cálcio foi CaCl2 a 8% que reduziu a severidade da doença em 69,5%. Foram avaliados também os microrganismos Rhodotorula sp. (LD-19 e Pseudomonas sp. fluorescente (P-2 isoladamente e associados ao CaCl2 a 8%. O tratamento dos frutos com os microrganismos foi realizado depositando-se 10 ml das suspensões (DO580= 0,7 sobre os ferimentos 24 horas após a aplicação do cálcio e duas horas antes da inoculação de Pcc. Houve diferença significativa entre os tratamentos, destacando-se a combinação CaCl2 a 8% + LD19, com RSD% de 93%. Os isolados P-2 e LD-19 aplicados isoladamente, apresentaram baixos percentuais de RSD.The effect of three calcium sources [CaCl2, Ca (CO32 and Ca (SO42] at 1; 2; 4; 6 and 8% (w/v were evaluated on control of soft rot caused by Pectobacterium carotovorum subsp. carotovorum (Pcc in tomato fruits. The calcium sources were applied using vacuum infiltration. Fruits were inoculated with pathogen 24 h later by deposition of 10 ml of a bacterial suspension containing 10(8 CFU/ml, on artificial wounds. Fruits were incubated in a moist chamber at 92±4% relative humidity during 48 h and evaluated by measuring the lesion

  15. Decisões judiciais sobre acesso aos medicamentos em Pernambuco

    Directory of Open Access Journals (Sweden)

    Artur Stamford

    2012-10-01

    Full Text Available OBJETIVO: Analisar as decisões do sistema jurídico sobre acesso da população a medicamentos no Sistema Único de Saúde por via judicial quanto a critérios de decisão e eventuais pressões políticas e econômicas. MÉTODOS: Estudo documental descritivo e retrospectivo de abordagem qualitativa e quantitativa. A coleta de dados foi realizada na Superintendência Estadual de Assistência Farmacêutica de Pernambuco, utilizando-se como fontes de dados 105 ações judiciais e relatórios administrativos de janeiro a junho de 2009. Verificaram-se os medicamentos com pedido ou carta patente no banco de dados do Instituto Nacional de Propriedade Industrial para identificar a frequência das patentes nas ações judiciais. Os dados obtidos foram classificados conforme o Sistema Anatômico Terapêutico Químico. Para análise das decisões judiciais, foi utilizada a teoria dos sistemas sociais autopoiéticos. RESULTADOS: As ações judiciais somaram 134 medicamentos com valor estimado de R$ 4,5 milhões para atender aos tratamentos solicitados; 70,9% dos medicamentos estavam com carta patente ou pedido e se concentraram em três classes terapêuticas: antineoplásicos e moduladores imunológicos, aparelho digestório e metabolismo, órgãos dos sentidos. Foram identificadas seis ideias centrais com os critérios de decisão dos magistrados (Constituição Federal e prescrição médica e as pressões entre os sistemas do direito, da economia e da política quanto ao acesso a medicamentos. CONCLUSÕES: A análise das decisões judiciais fundamentadas na teoria dos sistemas sociais autopoiéticos permitiu identificar as estimulações mútuas (dependências entre o sistema do direito e demais sistemas sociais em relação à questão do acesso dos cidadãos aos medicamentos. Essas dependências foram representadas pela Constituição Federal e pela propriedade intelectual. A Constituição Federal e a prescrição médica foram identificadas como

  16. Long-term validation of total and tropospheric column-averaged CH4 mole fractions obtained by mid-infrared ground-based FTIR spectrometry

    Directory of Open Access Journals (Sweden)

    T. Blumenstock

    2012-02-01

    Full Text Available At the Izaña Atmospheric Research Center high-resolution middle infrared solar absorption spectra have been recorded for more than 12 years using Fourier Transform InfraRed (FTIR spectrometers. We use the spectral fitting algorithm PROFFIT to retrieve long-term time series of methane (CH4 from the measured spectra. We investigate the total column-averaged dry-air mole fractions of methane (totXCH4 obtained from a scaling and a profile retrieval, and apply two approaches for deriving the tropospheric column-averaged dry-air mole fractions: firstly, we use the FTIR Hydrogen Fluoride (HF total column amounts as an estimator for the stratospheric CH4 contribution and a posteriori correct the totXCH4 data of a profile scaling retrieval accordingly (troXCH4post, and secondly, we directly determine the tropospheric column-averaged dry-air mole fractions of methane (troXCH4retr from retrieved CH4 profiles. Our theoretical estimation indicates that the scaling retrieval leads to totXCH4 amounts that are subject to a large smoothing error, which can be widely avoided by applying a profile retrieval (for the latter we estimate an overall precision of 0.41%. We compare the different FTIR CH4 data to Izaña's Global Atmospheric Watch (GAW surface in-situ CH4 data (CH4GAW, which in the case of the Izaña Atmospheric Research Center high mountain observatory are well representative for the free tropospheric CH4 amounts. Concerning totXCH4 the agreement between the FTIR data product and the in-situ measurement is rather poor documenting that totXCH4 is no valid free tropospheric CH4 proxy instead it is significantly affected by the varying stratospheric CH4 contribution and it rather follows the variation in the tropopause altitude. The a posteriori correction method only removes a part of this stratospheric CH4 contribution. On the contrary the profile retrieval allows for a direct estimation of the tropospheric column-averaged CH4 amounts. This troXCH4retr

  17. Long-term validation of tropospheric column-averaged CH4 mole fractions obtained by mid-infrared ground-based FTIR spectrometry

    Science.gov (United States)

    Sepúlveda, E.; Schneider, M.; Hase, F.; García, O. E.; Gomez-Pelaez, A.; Dohe, S.; Blumenstock, T.; Guerra, J. C.

    2012-06-01

    At the Izaña Atmospheric Research Center, high-resolution mid-infrared solar absorption spectra have been recorded for more than 12 yr using Fourier Transform InfraRed (FTIR) spectrometers. We use the spectral fitting algorithm PROFFIT to retrieve long-term time series of methane (CH4) from the measured spectra. We investigate the total column-averaged dry air mole fractions of methane (totXCH4) obtained from a profile scaling and a profile retrieval, and apply two approaches for deriving the tropospheric column-averaged dry air mole fractions: firstly, we use the FTIR hydrogen fluoride (HF) total column amounts as an estimator for the stratospheric CH4 contribution and a posteriori correct the totXCH4 data of a profile scaling retrieval accordingly (troXCH4post); secondly, we directly determine the tropospheric column-averaged dry air mole fractions of methane (troXCH4retr) from retrieved CH4 profiles. Our theoretical estimation indicates that the scaling retrieval leads to totXCH4 amounts that are subject to a large smoothing error, which can be widely avoided by applying a profile retrieval (for the latter we estimate an overall precision of 0.41%). We compare the different FTIR CH4 data to Izaña's Global Atmospheric Watch (GAW) surface in-situ CH4 data (CH4GAW), which in the case of the Izaña Atmospheric Research Center high mountain observatory are very representative for the free tropospheric CH4 amounts. Concerning totXCH4, the agreement between the FTIR data product and the in-situ measurement is rather poor documenting that totXCH4 is not a valid free tropospheric CH4 proxy, as it is significantly affected by the varying stratospheric CH4 contribution and it rather follows the variation in the tropopause altitude. The a posteriori correction method as applied here only removes a part of this stratospheric CH4 contribution. In contrast the profile retrieval allows for a direct estimation of the tropospheric column-averaged CH4 amounts. Results of the

  18. Long-term validation of tropospheric column-averaged CH4 mole fractions obtained by mid-infrared ground-based FTIR spectrometry

    Directory of Open Access Journals (Sweden)

    T. Blumenstock

    2012-06-01

    Full Text Available At the Izaña Atmospheric Research Center, high-resolution mid-infrared solar absorption spectra have been recorded for more than 12 yr using Fourier Transform InfraRed (FTIR spectrometers. We use the spectral fitting algorithm PROFFIT to retrieve long-term time series of methane (CH4 from the measured spectra. We investigate the total column-averaged dry air mole fractions of methane (totXCH4 obtained from a profile scaling and a profile retrieval, and apply two approaches for deriving the tropospheric column-averaged dry air mole fractions: firstly, we use the FTIR hydrogen fluoride (HF total column amounts as an estimator for the stratospheric CH4 contribution and a posteriori correct the totXCH4 data of a profile scaling retrieval accordingly (troXCH4post; secondly, we directly determine the tropospheric column-averaged dry air mole fractions of methane (troXCH4retr from retrieved CH4 profiles. Our theoretical estimation indicates that the scaling retrieval leads to totXCH4 amounts that are subject to a large smoothing error, which can be widely avoided by applying a profile retrieval (for the latter we estimate an overall precision of 0.41%. We compare the different FTIR CH4 data to Izaña's Global Atmospheric Watch (GAW surface in-situ CH4 data (CH4GAW, which in the case of the Izaña Atmospheric Research Center high mountain observatory are very representative for the free tropospheric CH4 amounts. Concerning totXCH4, the agreement between the FTIR data product and the in-situ measurement is rather poor documenting that totXCH4 is not a valid free tropospheric CH4 proxy, as it is significantly affected by the varying stratospheric CH4 contribution and it rather follows the variation in the tropopause altitude. The a posteriori correction method as applied here only removes a part of this stratospheric CH4 contribution. In contrast the profile retrieval allows for a direct estimation of the tropospheric column-averaged CH4 amounts. Results

  19. A Reflective Gaussian Coronagraph for ExAO: Laboratory Performance

    CERN Document Server

    Park, R; Siegler, N; Nielsen, E L; Stalcup, T; Park, Ryeojin; Close, Laird M.; Siegler, Nick; Nielsen, Eric L.; Stalcup, Thomas

    2006-01-01

    We report laboratory results of a coronagraphic test bench to assess the intensity reduction differences between a "Gaussian" tapered focal plane coronagraphic mask and a classical hard-edged "Top Hat" function mask at Extreme Adaptive Optics (ExAO) Strehl ratios of ~94%. However, unlike a traditional coronagraph design, we insert a reflective focal plane mask at 45 degree to the optical axis. We also used an intermediate secondary mask ("Mask_2") before a final image in order to block additional mask-edge diffracted light. The test bench simulates the 8.1m Gemini North telescope. It includes one spider vane, different mask radii (r= 1.9, 3.7, 7.4 lambda/D) and two types of reflective focal plane masks (hard-edged "Top Hat" and "Gaussian" tapered profiles). In order to investigate the relative performance of these competing coronagraphic designs with regard to extra-solar planet detection sensitivity, we utilize the simulation of realistic extra-solar planet populations (Nielson et al. 2006). With an appropri...

  20. Introdução ao Manual de Epicteto

    Directory of Open Access Journals (Sweden)

    Aldo Lopes Dinucci

    2012-01-01

    Full Text Available Trata-se da edição de divulgação de tradução do Manual de Epicteto realizada por Aldo Dinucci e Alfredo Julien. Epicteto, filósofo estoico grego nascido no ano 55 em Hierápolis, na Frígia, Ásia Menor (hoje Turquia, como Sócrates, nada escreveu. Seu pensamento nos chegou através de seu aluno Flávio Arriano (cidadão romano de origem grega, que compilou (possivelmente com auxílio da taquigrafia suas aulas em oito livros (As Diatribes de Epicteto, das quais quatro livros sobrevivem e constituiu o Encheirídion, termo que em grego significa "punhal, arma portátil ou livro portátil, manual". Este pequeno trabalho foi composto por Arriano tomando por base suas compilações das aulas de Epicteto. Consistindo num conjunto de apotegmas para que o seguidor do estoicismo tenha sempre ao alcance da mão os princípios para enfrentar as dificuldades da vida e vencê-las, o Encheirídion tornou célebre o nome de Epicteto.

  1. VALORES DO RNI DE PACIENTES SUBMETIDOS AO TRATAMENTO COM ANTICOAGULANTES

    Directory of Open Access Journals (Sweden)

    Simone Aparecida Matos de SOUZA

    2015-12-01

    Full Text Available Uma pesquisa exploratória de natureza qualitativa e quantitativa foi realizada durante o período de maio a agosto de 2013 no Laboratório de Análises Clínicas do Hospital das Clínicas localizado no município de Itaperuna, RJ. O objetivo foi analisar o perfil dos pacientes sob tratamento com anticoagulantes, demonstrando as potenciais variações nos valores da Relação Normalizada Internacional (RNI em comparação aos valores de referência bem como a frequência de realização de tais exames. Um questionário foi aplicado pouco antes da coleta do sangue, estabelecendo-se como critério de inclusão o uso de medicamentos anticoagulantes. Os resultados indicaram um total de 45 pacientes sob tratamento com anticoagulantes, sendo 32 do sexo feminino e 13 do sexo masculino. A maioria dos pacientes encontrava-se sob tratamento com o anticoagulante de uso oral varfarina e se encontrava com idade superior a 50 anos. O valor médio do RNI apresentou-se dentro dos limites considerados seguros, porém mais da metade dos pacientes apresentou RNI < 2,0 e a maioria dos pacientes sob tratamento com anticoagulantes não realiza a avaliação do RNI com frequência.

  2. Four year experience with the AO Anterior Thoracolumbar Locking Plate.

    Science.gov (United States)

    Thalgott, J S; Kabins, M B; Timlin, M; Fritts, K; Giuffre, J M

    1997-05-01

    For decades spinal surgeons have attempted to design simple, single stage anterior internal fixation systems for the thoracic and lumbar spine. Early devices presented both biomechanical and technical problems. The AO Anterior Thoracolumbar Locking Plate (ATLP) was designed to solve some of the problems encountered with early anterior instrumentation. The ATLP system is constructed in Commercially Pure titanium. It is a low profile device indicated for use for unstable burst fractures in the anterior column; metastatic tumor management; and degenerative diseases of the thoracolumbar spine between levels T10 and L5. Implantation of the device involves direct anterior decompression with sagittal reduction and corpectomy. This is followed by grafting reconstruction, and plate fixation. This device has been implanted in 25 patients with an average follow-up of 38 months. There were five (5) broken screws in three (3) patients, and no broken plates. Implant related postoperative complications included two misplaced screws. Preliminary results indicate that the ATLP system seems to be a safe, low profile, MRI/CT compatible device that provides definitive single stage fixation of the anterior spinal column. PMID:9160452

  3. A avaliçao da concretizaçao do processo de Bolonha numa instituiçao de ensino superior portuguesa

    Directory of Open Access Journals (Sweden)

    Pedro Rocha Dos Reis

    2009-01-01

    Full Text Available A questão central do Processo de Bolonha consiste na mudança de paradigma de ensino, implicando a transição de um modelo passivo, fortemente centrado na aquisição de conhecimentos, para um modelo baseado no desenvolvimento de competências, onde a componente experimental e de projecto desempenham um papel importante. Concluídos dois anos de funcionamento dos seus cursos de 1º Ciclo, a Escola Superior de Educação de Santarém (Portugal procedeu a uma avaliação da implementação do Processo de Bolonha ao nível dos cursos. Este artigo apresenta os resultados dessa reflexão alargada. A partir da análise de dados recolhidos junto dos coordenadores (através de entrevista e dos professores e alunos dos cursos (através de questionário, conclui-se que o balanço da implementação do Processo de Bolonha é francamente positivo. Com efeito, permitiu, por um lado, uma maior reflexão sobre os perfis profissionais e centrar o processo formativo nas experiências educativas e nas aprendizagens, nomeadamente as adquiridas no âmbito dos programas de mobilidade, por outro lado, permitiu também uma maior articulação entre a actividade docente, de tutoria e a componente prática. Apesar de tudo, subsistem questões por aprofundar emelhorar, as quais irão sendo trabalhadas em função das avaliações que forem sendo feitas.The main issue of the Bologna’s Process consists in a change of the teaching paradigm, implying the transition of a passive model, strongly focused in the knowledge acquisition, for a model based in the skills development, where the experimental component and the project play an important role. Completed two years of operation of their courses of the FirstCicle, the Higher School of Education of Santarem (Portugal carriedon with the evaluation of the implementation of the Bologna’s Process at the courses’level. This article presents the results of this extended reflection.From the analysis of data collected from

  4. Sexual maturity and litter size in short-tailed mole rat Nesokia indica%印度地鼠的性成熟和窝仔数

    Institute of Scientific and Technical Information of China (English)

    Rubina ARSHAD; Mirza Azhar BEG

    2004-01-01

    The breeding pattern of 348 short-tailed mole rats Nesokia indica inhabiting the non-crop areas of the central Punjab (Pakistan) was studied for effective vertebrate pest control. Of 107 males and 241 females trapped, 75 and 179,respectively, were sexually mature. The sex ratio revealed a predominance of females. Body weight and body length were used as indices of age of the trapped specimens of the short-tailed mole rat. The smallest sexually mature male rats were recorded in the body weight class 70 - 89 g and body length class 13.1 - 14.0 cm. The smallest sexually mature females were found in the body weight class 70 - 89 g and the body length class 12.1 - 13.0 cm. The average number of embryos in a litter size was 2.74 ± 0.15 (range, 1 - 5), whereas the average number of placental scars was 4.29 ± 0.19(1 - 11 ). Body weight classes appeared to have significant effect on litter size, whereas body length classes and estimated age had no significant effect on the size of litter. Pest control could be most effective when rats are reproductively inactive and are not breeding [Acta Zoologica Sinica 50 (5): 723-729, 2004].%为有效地进行有害脊椎动物的控制,研究了栖息于巴基斯坦Punjab中部的348只印度地鼠的繁殖模式.在所捕捉到的107雄鼠和241只雌鼠中,分别有75只和179只是性成熟的个体.性比偏雌.使用被捕个体标本的体重和体长作为指标,发现最小的性成熟的雄性个体体重为70-89 g,体长13.1-14.0 cm;一窝仔里面的平均胚胎数为2.74±0.15(范围,1-5),而平均胎斑数为4.29±0.19(1-11).体重似乎对窝仔数有显著影响,而体长和估计的年龄对窝仔数没影响.当老鼠繁殖不活跃和不繁殖时,控制害兽最有效[动物学报50(5):723 729,2004].

  5. A low-fluorine solution with a 2:1 F/Ba mole ratio for the fabrication of YBCO films

    International Nuclear Information System (INIS)

    In previously reported low-fluorine MOD-YBCO studies, the lowest F/Ba mole ratio of the precursor solution was 4.5. Further lowering the F/Ba ratio would bring benefits for the environment, thick film deposition, and an understanding of the heat treatment process. On the other hand, the F/Ba ratio must be at least 2 for full conversion of the Ba-precursor to BaF2 to avoid the formation of BaCO3, which is detrimental to the superconducting performance of YBCO films. In this study, a solution with a 2:1 F/Ba mole ratio was developed, and the fluorine content of this solution was approximately only 10.3% of that used in the conventional TFA-MOD method. Attenuated total reflectance-Fourier transform-infrared spectra (ATR-FT-IR) revealed that BaCO3 was remarkably suppressed in the as-pyrolyzed film—and eliminated at 700 °C. Thus, YBCO films with a critical current density (Jc) of over 5 MA cm−2 (77 K, 0 T, 200 nm thickness) could be obtained on lanthanum aluminate single-crystal substrates. In situ FT-IR spectra showed that no obvious fluorinated gaseous by-products were detected in the pyrolysis step, which indicated that all F atoms might remain in the film as fluorides. X-ray diffraction θ/2θ scans showed the presence of BaF2—but not of Y F3 or CuF2—in films quenched at 400–800 °C. The formation priority of BaF2 over Y F3 and CuF2 was interpreted by examining the chemical equilibrium of the potential reactions. Our study could enlarge the synthesis window of precursor solutions for MOD-YBCO fabrication, and serve as a foundation for continuously and systematically studying the influence of fluorine content in the precursor solutions. (paper)

  6. 完全性葡萄胎与胎儿共存临床研究%Clinical study of complete hydatidiform mole and co-existing fetus

    Institute of Scientific and Technical Information of China (English)

    李珠玉; 陈海天; 彭软; 王子莲; 游泽山

    2015-01-01

    Objective To explore the clinical characteristics and pregnancy outcomes of complete hy-datidiform mole and co-existing fetus (CMCF).Methods The data of six CMCF women were analyzed retro-spectively.Results Among six CMCF women,five were pregnant after in vitro fertilization and embryo trans-plantation,and one after ovulation-stimulating treatment.Five patients were diagnosed with CMCF in middle pregnancy and one in early pregnancy.Five cases had twin pregnancy with complete hydatidiform mole and one was triplet pregnanct.One case insisted on continuous pregnancy,four accepted pregnancy termination and one was forced to terminate pregnancy.All six women and one fetus survived.Conclusions The incidence of CM-CF is probably correlated with the application of assisted reproductive technology.Clinical outcomes depend on disease progression,fetal chromosome and patients’willingness.If the fetal chromosome is normal and no seri-ous maternal complications occur during pregnancy,the fetus may survive.However,the risk of continuous pregnancy remains to be evaluated.%目的:探讨完全性葡萄胎与胎儿共存(CMCF)的临床特征及妊娠结局。方法收集并分析6例 CMCF 的临床资料。结果6例中,体外受精-胚胎移植术后妊娠5例,促排卵治疗后妊娠1例;妊娠中期发现5例,妊娠早期发现1例;双胎之一完全性葡萄胎5例,三胎之一完全性葡萄胎1例;要求继续妊娠1例,要求终止妊娠4例,被迫终止妊娠1例。6例产妇均存活,胎儿存活1例。结论CMCF 的发生可能与应用辅助生殖技术相关,其结局取决于病情发展、胎儿染色体及患者意愿。若胎儿染色体正常,且妊娠期间未出现严重母体并发症,有分娩活胎可能,但其继续妊娠的风险评估仍需进一步的研究。

  7. INTRODUÇAO AOS MODELOS ODE PARTICIPAÇÃO DE MERCADO EM SERVIÇOS DE TRANSPORTES

    Directory of Open Access Journals (Sweden)

    Antonio Galvão Novaes

    2010-04-01

    Full Text Available

    Análises de participação de mercado ("market share" são comuns em estudos na área de "marketing", envolvendo produtos e respectivas marcas, de um lado, o perfil da demanda de outro, e o posicionamento das empresas produtoras que competem nesse mercado, num terceiro bloco. No setor de transportes a literatura registra aplicações em ligações aéreas e em serviços intermunicipais de ônibus. Os modelos de participação de mercado se aplicam normalmente a situações em que os operadores oferecem serviços de transportes similares num determinado mercado, com a competição sendo feita não com base em atributos modais intrínsecos, mas sim apoiada em características diferenciadoras intra-modais mais tênues, tais como conforto, atendimento, promoções tarifárias, "marketing" e propaganda, etc. Neste artigo é feita uma introdução aos modelos de "market share" em transportes, com a apresentação de um exemplo de aplicação ao transporte intermunicipal de passageiros em ônibus, sendo discutidos também aspectos ligados a calibração e tais modelos.

    ABSTRACT

    Market share analysis is common in marketing studies involving products and respective brands, on one hand, the demand profile on the other hand, and the competiting industries on a third set. In the transport sector the literature registers a number of applications to air transport problems and to intercity bus services. Market share models are normally applied to situations in which operators offer, in a specific market, transport services that are similar in nature, with competition based not on intrinsic modal attributes, but rather on more tenous intra-mode differentiating characteristics, such as comfort, attendance, tariff promotions, marketing and advertising efforts, etc (sub-modal configurations. It is presented in this paper an introduction to market share modelling in transport, with an example concerning an intercity bus service in

  8. The nature of ethnic identity among the people of Curaçao

    NARCIS (Netherlands)

    Dijs, N.M. van der

    2011-01-01

    This qualitative research explores the nature of ethnic identity among the people of Curaçao. The questions that are of fundamental interest to this study are: how do the people of Curaçao perceive themselves ethnically, how do they experience their sense of belonging to an ethnic group and what fac

  9. Freshwater Bryozoa (Phylactolaemata) from Curaçao, Aruba and Bonaire

    NARCIS (Netherlands)

    Lacourt, A.W.

    1955-01-01

    The Phylactolaemata-fauna of Curaçao, Aruba and Bonaire, as it appears from the samples collected by dr P. Wagenaar Hummelinck, is connected with the fauna of the South-American mainland. The material belongs to three species only: Hyalinella agilis — Curaçao, Aruba, Bonaire — in temporary or semi-p

  10. Status Update and Closed-Loop Performance of the Magellan Adaptive Optics VisAO Camera

    CERN Document Server

    Kopon, Derek; Males, Jared; Gasho, Victor; Morzinski, Katie; Follette, Katherine

    2014-01-01

    We present laboratory results of the closed-loop performance of the Magellan Adaptive Optics (AO) Adaptive Secondary Mirror (ASM), pyramid wavefront sensor (PWFS), and VisAO visible adaptive optics camera. The Magellan AO system is a 585-actuator low-emissivity high-throughput system scheduled for first light on the 6.5 meter Magellan Clay telescope in November 2012. Using a dichroic beamsplitter near the telescope focal plane, the AO system will be able to simultaneously perform visible (500-1000 nm) AO science with our VisAO camera and either 10 micron or 3-5 micron science using either the BLINC/MIRAC4 or CLIO cameras, respectively. The ASM, PWS, and VisAO camera have undergone final system tests in the solar test tower at the Arcetri Institute in Florence, Italy, reaching Strehls of 37% in i'-band with 400 modes and simulated turbulence of 14 cm ro at v-band. We present images and test results of the assembled VisAO system, which includes our prototype advanced Atmospheric Dispersion Corrector (ADC), prot...

  11. Patterns of Impairments in AOS and Mechanisms of Interaction between Phonological and Phonetic Encoding

    Science.gov (United States)

    Laganaro, Marina

    2012-01-01

    Purpose: One reason why the diagnosis of apraxia of speech (AOS) and its underlying impairment are often debated may lie in the fact that most patients do not display pure patterns of AOS. Mixed patterns are clearly acknowledged at other levels of impairment (e.g., lexical-semantic and lexical-phonological), and they have contributed to debate…

  12. Optimal control strategy to reduce the temporal wavefront error in AO systems

    NARCIS (Netherlands)

    Doelman, N.J.; Hinnen, K.J.G.; Stoffelen, F.J.G.; Verhaegen, M.H.

    2004-01-01

    An Adaptive Optics (AO) system for astronomy is analysed from a control point of view. The focus is put on the temporal error. The AO controller is identified as a feedback regulator system, operating in closed-loop with the aim of rejecting wavefront disturbances. Limitations on the performance of

  13. Biomonitoring of the genotoxic effects and oxidative potentials of commercial edible dung beetles (Onitis sp.), grasshopper (Caelifera sp.) and mole crickets (Gryllotalpa sp.) in vitro.

    Science.gov (United States)

    Koc, Kubra; Incekara, Umit; Turkez, Hasan

    2014-09-01

    In this investigation, the genotoxic and oxidative effects of water soluble extracts of dung beetles, flying grasshopper and mole crickets have been assessed on cultured human blood cells. The extracts were added to the culture tubes at 12 different concentrations (0-2000 ppm). Micronucleus test was used to monitor the DNA and the chromosomal damage produced by aqueous extracts in vitro. In addition, to assess the oxidative effects, total antioxidant capacity (TAC) and total oxidant status (TOS) levels were also measured. Our results indicated that these extracts did not show genotoxic effects at the tested concentrations. However, the extracts caused dose-dependent alterations in both TAC and TOS levels. Based on the findings, it was concluded that the studied insects can be consumed safely, but it is necessary to consider the cellular damages which are likely to appear depending on oxidative stress at higher concentrations. It has also been suggested that this in vitro approach for oxidative and genotoxicity assessments may be useful to evaluate the potential health risks of edible insects. PMID:24700298

  14. N2 Mole Fraction Dependence of Plasma Bullet Propagation in Premixed He/N2 Plasma Needle Discharge at Atmospheric Pressure

    Science.gov (United States)

    Ni, Gengsong; Qian, Muyang; Yang, Congying; Liu, Sanqiu; Wang, Dezhen

    2016-07-01

    In this work, a computational modeling study on the mechanism of the acceleration behavior of a plasma bullet in needle-plane configuration is presented. Above all, in our model, two sub-models of time-dependent plasma dynamics and laminar flow are connected using a oneway coupled method, and both the working gas and the surrounding gas around the plasma jet are assumed to be the same, which are premixed He/N2 gas. The mole fractions of the N2 (NMF) ingredient are set to be 0.01%, 0.1% and 1% in three cases, respectively. It is found that in each case, the plasma bullet accelerates with time to a peak velocity after it exits the nozzle and then decreases until getting to the treated surface, and that the velocity of the plasma bullet increases at each time moment with the peak value changing from 0.72×106 m/s to 0.80×106 m/s but then drops more sharply when the NMF varies from 0.01% to 1%. Besides, the electron impact ionizations of helium neutrals and nitrogen molecules are found to have key influences on the propagation of a plasma bullet instead of the penning ionization. supported by National Natural Science Foundation of China (No. 11465013), the Natural Science Foundation of Jiangxi Province, China (No. 20151BAB212012), and in part by the International Science and Technology Cooperation Program of China (No. 2015DFA61800)

  15. Mapping intercellular CO2 mole fraction (Ci) in rosa rubiginosa leaves fed with abscisic acid by using chlorophyll fluorescence imaging. Significance Of ci estimated from leaf gas exchange

    Science.gov (United States)

    Meyer; Genty

    1998-03-01

    Imaging of photochemical yield of photosystem II (PSII) computed from leaf chlorophyll fluorescence images and gas-exchange measurements were performed on Rosa rubiginosa leaflets during abscisic acid (ABA) addition. In air ABA induced a decrease of both the net CO2 assimilation (An) and the stomatal water vapor conductance (gs). After ABA treatment, imaging in transient nonphotorespiratory conditions (0.1% O2) revealed a heterogeneous decrease of PSII photochemical yield. This decline was fully reversed by a transient high CO2 concentration (7400 mol mol-1) in the leaf atmosphere. It was concluded that ABA primarily affected An by decreasing the CO2 supply at ribulose-1,5-bisphosphate carboxylase/oxygenase. Therefore, the An versus intercellular mole fraction (Ci) relationship was assumed not to be affected by ABA, and images of Ci and gs were constructed from images of PSII photochemical yield under nonphotorespiratory conditions. The distribution of gs remained unimodal following ABA treatment. A comparison of calculations of Ci from images and gas exchange in ABA-treated leaves showed that the overestimation of Ci estimated from gas exchange was only partly due to heterogeneity. This overestimation was also attributed to the cuticular transpiration, which largely affects the calculation of the leaf conductance to CO2, when leaf conductance to water is low. PMID:9501127

  16. Overexpression of the hydatidiform mole-related gene F10 inhibits apoptosis in A549 cells through downregulation of BCL2-associated X protein and caspase-3.

    Science.gov (United States)

    Song, Yali; Zhang, Gong; Zhu, Xiulan; Pang, Zhanjun; Xing, Fuqi; Quan, Song

    2012-09-01

    The aim of this study was to investigate how the overexpression of the hydatidiform mole-related gene F10 affects apoptosis in human lung cancer A549 cells. A549 cells were transfected with pEGFP-N1-F10 (A549-F10) or pEGFP-N1 empty vector (A549-empty). Untransfected A549, A549-F10 or A549-empty cells were examined using the MTT cell proliferation assay and the TUNEL-FITC/Hoechst 33258 apoptosis assay. Western blotting was used to examine the expression levels of the pro-apoptotic genes, BCL2-associated X protein (BAX) and caspase-3. F10 was stably expressed in A549 cells. From 12 h, A549-F10 cells proliferated markedly faster than the untransfected and A549-empty cells. F10 overexpression also significantly inhibited apoptosis, as shown by the reduced number of TUNEL and Hoechst 33258 double-positive cells. This inhibition was likely due to an F10-induced reduction in the BAX and caspase-3 levels. The results of this study indicate that F10 overexpression inhibits apoptosis in A549 cells through the downregulation of the pro-apoptotic genes BAX and caspase-3. PMID:23741243

  17. Mineral sulphide-lime reactions and effect of CaO/C mole ratio during carbothermic reduction of complex mineral sulphides

    Science.gov (United States)

    Hara, Yotamu Stephen Rainford

    2014-01-01

    Mineral sulphide (MS)-lime (CaO) ion exchange reactions (MS + CaO = MO + CaS) and the effect of CaO/C mole ratio during carbothermic reduction (MS + CaO + C = M + CaS + CO(g)) were investigated for complex froth flotation mineral sulphide concentrates. Phases in the partially and fully reacted samples were characterised by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The primary phases during mineral sulphide-lime ion exchange reactions are Fe3O4, CaSO4 Cu2S, and CaS. A complex liquid phase of Ca2CuFeO3S forms during mineral sulphide-lime exchange reactions above 1173 K. The formation mechanisms of Ca2CuFeO3S liquid phase are determined by characterising the partially reacted samples. The reduction rate and extent of mineral sulphides in the presence of CaO and C increase with the increase in CaO/C ratio. The metallic phases are surrounded by the CaS rich phase at CaO/C > 1, but the metallic phases and CaS are found as separate phases at CaO/C gangue minerals (SiO2 and Al2O3) are only observed at CaO/C > 1 and the reacted samples are excessively sintered.

  18. Microhabitat types promote the genetic structure of a micro-endemic and critically endangered mole salamander (Ambystoma leorae) of Central Mexico.

    Science.gov (United States)

    Sunny, Armando; Monroy-Vilchis, Octavio; Reyna-Valencia, Carlos; Zarco-González, Martha M

    2014-01-01

    The reduced immigration and emigration rates resulting from the lack of landscape connectivity of patches and the hospitality of the intervening matrix could favor the loss of alleles through genetic drift and an increased chance of inbreeding. In order for isolated populations to maintain sufficient levels of genetic diversity and adapt to environmental changes, one important conservation goal must be to preserve or reestablish connectivity among patches in a fragmented landscape. We studied the last known population of Ambystoma leorae, an endemic and critically threatened species. The aims of this study were: (1) to assess the demographic parameters of A. leorae and to distinguish and characterize the microhabitats in the river, (2) to determine the number of existing genetic groups or demes of A. leorae and to describe possible relationships between microhabitats types and demes, (3) to determine gene flow between demes, and (4) to search for geographic locations of genetic discontinuities that limit gene flow between demes. We found three types of microhabitats and three genetically differentiated subpopulations with a significant level of genetic structure. In addition, we found slight genetic barriers. Our results suggest that mole salamander's species are very sensitive to microhabitat features and relatively narrow obstacles in their path. The estimates of bidirectional gene flow are consistent with the pattern of a stepping stone model between demes, where migration occurs between adjacent demes, but there is low gene flow between distant demes. We can also conclude that there is a positive correlation between microhabitats and genetic structure in this population. PMID:25076052

  19. Doscientos aos de Ciencias de la Tierra en la Argentina

    Directory of Open Access Journals (Sweden)

    Victor A. Ramos

    2011-09-01

    Full Text Available La historia de las Ciencias de la Tierra en la Argentina desde la Revolucin de Mayo muestra cuatro etapas diferentes relacionadas a cambios polticos mayores. El pasaje de una organizacin colonial controlada desde la metrpolis a un nuevo gobierno regional marc la necesidad imperiosa de fundar nuevas instituciones donde las bases de la ciencia pudieran ser impartidas. La etapa de las "Ciencias de Rivadavia" (1810-1830 represent un gran esfuerzo personal en esa direccin y aunque la mayor parte de sus iniciativas fracasaron, al menos dos instituciones por l creadas permanecen hasta el presente. La segunda etapa (1830-1853 estuvo dominada por los viajeros extranjeros, perodo en que personalidades como Alcide d'Orbigny y Charles Darwin llegaron al pas e hicieron contribuciones universales a las Ciencias de la Tierra basadas en observaciones locales que arrojaron luz en importantes procesos. La tercera etapa corresponde a la organizacin nacional (1853 hasta las primeras dcadas del siglo XX, cuando nuevas autoridades establecieron algn orden y promovieron la creacin de nuevas instituciones. La actitud proactiva hacia las ciencias bsicas de Juan Mara Gutirrez en la Universidad de Buenos Aires, tanto como las acciones del presidente Domingo F. Sarmiento para la Universidad de Crdoba, fueron la piedra fundamental para comenzar la investigacin y la enseanza de las Ciencias de la Tierra en la Argentina. Tan temprano como en 1865, con los primeros especialistas en Ciencias de la Tierra que vinieron de Italia, comenz la enseanza de la geologa en la Universidad de Buenos Aires, y unos pocos aos ms tarde los gelogos alemanes hicieron lo mismo en Crdoba. Estos dos hechos fundacionales consolidaron la cuarta etapa, cuando una serie de instituciones creadas en el siglo XX promueven el desarrollo presente de las Ciencias de la Tierra en todo el pas.

  20. A reflective Gaussian coronagraph for ExAO: laboratory performance

    Science.gov (United States)

    Park, Ryeojin; Close, Laird M.; Siegler, Nick; Nielsen, Eric L.; Stalcup, Thomas

    2006-06-01

    We report laboratory results of a coronagraphic testbed to assess the intensity reduction differences between a "Gaussian" tapered focal plane coronagraphic mask and a classical hard-edged "Top Hat" function mask at Extreme Adaptive Optics (ExAO) Strehl ratios of ~94%. However, unlike a traditional coronagraph design, we insert a reflective focal plane mask at 45 ° to the optical axis and used a "spot of Arago blocker" (axicon stop) before a final image in order to block additional mask edge-diffracted light. The testbed simulates the optical train of ground-based telescopes (in particular the 8.1m Gemini North telescope) and includes one spider vane and different mask radii (r= 1.9λ/D, 3.7λ/D, 7.4λ/D) and two types of reflective focal plane masks (hard-edged "Top Hat" and "Gaussian" tapered profiles). In order to investigate the performance of these competing coronagraphic designs with regard to extra-solar planet detection sensitivity, we utilize the simulation of realistic extra-solar planet populations (Nielsen et al. 2006). With an appropriate translation of our laboratory results to expected telescope performance, a "Gaussian" tapered mask radius of 3.7λ/D with an axicon stop performs best (highest planet detection sensitivity). For a full survey with this optimal design, the simulation predicts ~30% more planets detected compared to a similar sized "Top Hat" function mask with an axicon stop. Using the best design, the "point contrast ratio" between the stellar PSF peak and the coronagraphic PSF at 10λ/D (0.4" in H band if D = 8.1m) is 1.4 x 10 6. This is ~10 times higher than a classical Lyot "Top Hat" coronagraph.

  1. Do gozo fálico ao gozo do Outro

    Directory of Open Access Journals (Sweden)

    Maria das Graças Leite Villela Dias

    2008-12-01

    Full Text Available Para além da significação fálica, fato de estrutura tanto para o sujeito masculino quanto para o sujeito feminino, Lacan aponta para um outro tipo de gozo: um gozo suplementar, o gozo do Outro, o gozo feminino, para além do falo. Do S1, significante do gozo fálico, que inscreve a lógica da significação fálica, tal como é demonstrado por meio da formulação do discurso do mestre, Lacan passa ao S (A como forma de escritura da inexistência do Outro sexo e da conseqüente impossibilidade da relação sexual, tal como é comprovado na escrita da fórmula algébrica do discurso do analista.From the phallic jouissance to the jouissance of the Other. Beyond phallic signification, structuring element for both the male subject and the female subject, Lacan points to another type of jouissance, a supplementary jouissance, the jouissance of the Other, the feminine jouissance, beyond the phallus. From the S1, signifier for the phallic jouissance, which inscribes the logic of the phallic signification, in so much as it is demonstrated through the formulation of the master's discourse, Lacan goes to S (A as a means of writing the non-existence of the Other sex and of the consequent impossibility of the sexual relation, as can be proved through the writing of the algebraic formulae of the analyst's discourse.

  2. LDEF (Postflight), AO201 : Interplanetary Dust Experiment, Tray B12

    Science.gov (United States)

    1990-01-01

    LDEF (Postflight), AO201 : Interplanetary Dust Experiment, Tray B12 The postflight photograph shows little change of the exposed surfaces when compared with the prelaunch photograph. Although not noticable in the photograph, a light coating of contamination was seen on all experiment surfaces in this location. The difference in colors of the IDE detectors, located on the right hand mounting plate, is a result of the reflected surroundings and not related to space exposure. A close observation of the detector surfaces reveal that some damage has occured from meteroid and/or debris impacts. One impact crater can be seen, upper right quadrant, on the detector located in the sixth (6th) row down from the top and the fifth (5th) row from the right. Other impacts, smaller in size, show as small white dots on the detector surface. The solar sensor seems to have changed little, if any. However, the color of the solar array baseplate, showing indications of contamination, appears to be darker than the detector mounting plate. The center section cover plate shows little change when compared with the pre-launch photograph. However, during inspection, a light coat of the brown contamination has been observed on all surfaces. The color of the bonding material (RTV) used to secure several thin specimen, sapphire, to individual mounting plates has changed from pink to gold. At one location, that of a single specimen, the bonding material is more gray than gold in color. This has been attributed to the specimen being considerably thicker. The EPDS thermal cover in the right hand side of the tray shows a light coating of brown contamination on the Chemglaze II A-276 white paint.

  3. Óleos essenciais e extratos vegetais no controle da podridão mole em alface crespa Essential oils and plant extracts on the control of soft rot of crispy lettuce

    Directory of Open Access Journals (Sweden)

    Cristiane L Silva

    2012-12-01

    Full Text Available Avaliou-se o efeito de óleos essenciais e extratos vegetais no controle da podridão mole em alface, bem como, a influência desses produtos nas características físico-químicas desta hortaliça. Nos testes in vitro, discos de papel de filtro foram embebidos em 11 óleos essenciais e 20 extratos vegetais nas concentrações 0,0; 0,25; 0,50; 0,75 e 1% e 0,0; 10, 40, 70 e 100%, respectivamente, e depositados sobre meio de cultura contendo Pectobacterium carotovorum subsp. carotovorum (Pcc A1. Os halos de inibição foram mensurados após 24 e 48 h de incubação. Em casa de vegetação, plantas de alface cv. Veneranda foram tratadas com 11 óleos nas concentrações de 0,5 e 1%, 20 extratos na concentração de 10% e Mycoshield® (3 g L-1, sendo inoculadas com o isolado Pcc A1 após 72 h. A severidade da doença foi avaliada a intervalos de seis até 48 h, calculando-se a área abaixo da curva de progresso da doença (AACPD. Em experimento similar, plantas tratadas com óleo de Corymbia citriodora, sete extratos e Mycoshield® foram analisadas quanto aos teores de sólidos solúveis, vitamina C, acidez titulável e pH. Pcc A1 não foi inibido in vitro. Dois óleos (C. citriodora e Citrus sinensis e sete extratos (Parkinsonia aculeata, Chamaecrista cytisoides, Sida galherensis, Polygala violaceae, Chamaecrista desvauxii e Pityrocarpa moniliformis reduziram significativamente a severidade da doença em relação à testemunha, não diferindo do controle Mycoshield®. Já a AACPD foi reduzida por oito óleos e dez extratos. Destacaram-se com eficiência similar ao Mycoshield® e diferindo da testemunha (7,5 e 132,3 nas duas variáveis analisadas, o óleo de C. citriodora a 0,5% e o extrato de S. galherensis a 10% com severidades de 3,6 e 3,5 e AACPD de 83,35 e 88,25, respectivamente. Os teores de vitamina C, acidez titulável e pH não foram alterados em folhas de alface tratadas com óleo de C. citriodora e extratos de P. aculeata e C. cytisoides

  4. Common Moles, Atypical Moles (Dysplastic Nevi), and Risk of Melanoma

    Science.gov (United States)

    ... describes the features of early melanoma ( 2 , 5 ): Asymmetry . The shape of one half does not match ... Twitter Instagram YouTube Google+ LinkedIn GovDelivery RSS CONTACT INFORMATION Contact Us LiveHelp Online Chat MORE INFORMATION About ...

  5. Schedule control in Ling Ao nuclear power project

    International Nuclear Information System (INIS)

    Ling Ao Nuclear Power Station (LANP) is first one built up by self-reliance in China with power capacity 990x2 MWe. The results of quality control, schedule control and cost control are satisfactory. The commercial operation days of Unit 1 and Unit 2 were 28th May 2002 and 8th Jan. 2003 respectively, which were 48 days and 66 days in advance of the project schedule. This paper presents the practices of self-reliance schedule control system in LANP. The paper includes 10 sections: schedule control system; targets of schedule control; schedule control at early stage of project; construction schedule; scheduling practice; Point curves; schedule control of design and procurement; a good practice of construction schedule control on site; commissioning and startup schedule; schedule control culture. Three figures are attached. The main contents of the self-reliance schedule control system are as follows: to draw up reasonable schedules and targets; to setup management mechanism and procedures; to organize powerful project management team; to establish close monitoring system; to provide timely progress reports and statistics information. Five kinds of schedule control targets are introduced, i.e. bar-chart schedule; milesones; Point curves; interface management; hydraulic test schedule of auxiliary piping loops; EMR/EMC/EESR issuance schedules. Six levels of bar-chart schedules were adopted in LANP, but the bar-chart schedules were not satisfactory for complicated erection condition on site, even using six levels of schedules. So a kind of Point curves was developed and their advantages are explained. Scheduling method of three elements: activity, duration, logic, which was adopted in LANP, is introduced. The duration of each piping activities in LANP level 2 project schedule was calculated based on the relevant working Point quantities. The analysis and adjustment of Point curves are illustrated, i.e. balance of monthly quantities; possible production in the peakload

  6. SCExAO as a precursor to an ELT exoplanet direct imaging instrument

    CERN Document Server

    Jovanovic, Nemanja; martinache, Frantz; Clergeon, Christophe; Singh, Garima; Vievard, Sebastien; Kudo, Tomoyuki; Garrel, Vincent; Norris, Barnaby; Tuthill, Peter; Stewart, Paul; huby, Elsa; Perrin, Guy; Lacour, Sylvestre

    2013-01-01

    The Subaru Coronagraphic Extreme AO (SCExAO) instrument consists of a high performance Phase Induced Amplitude Apodisation (PIAA) coronagraph combined with an extreme Adaptive Optics (AO) system operating in the near-infrared (H band). The extreme AO system driven by the 2000 element deformable mirror will allow for Strehl ratios >90% to be achieved in the H-band when it goes closed loop. This makes the SCExAO instrument a powerful platform for high contrast imaging down to angular separations of the order of 1lambda/D and an ideal testbed for exploring coronagraphic techniques for ELTs. In this paper we report on the recent progress in regards to the development of the instrument, which includes the addition of a visible bench that makes use of the light at shorter wavelengths not currently utilized by SCExAO and closing the loop on the tip/tilt wavefront sensor. We will also discuss several exciting guest instruments which will expand the capabilities of SCExAO over the next few years; namely CHARIS which i...

  7. Ressecção de metástase hepática de sarcomas de partes moles Liver resection for metastatic soft tissue sarcomas

    Directory of Open Access Journals (Sweden)

    Rinaldo Gonçalves da Silva

    2006-12-01

    Full Text Available OBJETIVO: Avaliar os resultados do tratamento cirúrgico de pacientes portadores de metástases hepáticas de sarcomas de partes moles, com ênfase na identificação de fatores prognósticos e estudo de sobrevida. MÉTODO: Foi realizada análise retrospectiva de pacientes submetidos a ressecções hepáticas por sarcomas de partes moles metastáticos para fígado no Instituto Nacional de Câncer - MS entre 1992 e 2002. Fatores demográficos, características do tumor primário e dos tumores metastáticos, intervalo de surgimento de metástases, tipo de ressecção e resultados de sobrevida global e livre de doença, considerados a partir da operação para o tumor metastático foram considerados. Os dados obtidos foram analisados estatisticamente através dos softwares SPSS versão 8 e EpiInfo 2002.. RESULTADOS: O tumor primário era localizado no trato gastrintestinal em cinco pacientes, no retroperitônio em quatro e nos dois restantes no útero e no músculo deltóide. Leiomiossarcoma foi a linhagem histológica em 10 casos e dermatofibrossarcoma no caso restante, com grau de diferenciação tumoral G2 em seis casos e G3 em cinco. A extensão da ressecção hepática foi a segmentectomia em cinco pacientes, a lobectomia em quatro e as ressecções maiores em dois pacientes. Dois pacientes tiveram ressecções extra-hepáticas associadas. A ressecção foi completa em sete pacientes, persistindo doença residual macroscópica em quatro pacientes. Pela análise multivariada a sobrevida foi afetada pela radicalidade da ressecção, com 49 meses para as cirurgias completas e 15 meses para as incompletas (pBACKGROUND: The objective of this study was to evaluate the surgical treatment of patients with liver metastasis of soft tissue sarcomas, with emphasis on the identification of prognostic factors and survival. METHODS: This is a retrospective analysis of liver resections for metastatic soft tissue sarcomas performed at National Institute of

  8. O INCENTIVO FISCAL EMPRESARIAL COMO FORMA DE PROTEÇÃO AO MEIO AMBIENTE

    OpenAIRE

    Patrícia Machado Iserhardt

    2013-01-01

    O presente artigo se refere ao incentivo fiscal empresarial como forma de proteção ao meio ambiente. A função extrafiscal dos tributos é de extrema importância ao meio ambiente, pois, assim, o Estado através da arrecadação de receitas tem a possibilidade de implementar ações que visem a proteção do meio ambiente. Portanto, o mecanismo hora estudado, vem mostrar que há possibilidade de inserir a classe empresarial na contemplação deste mecanismo de proteção. A classe empresarial pode participa...

  9. Calibration of a curvature sensor/bimorph mirror AO system: interaction matrix measurement on MACAO systems

    Science.gov (United States)

    Oberti, Sylvain; Bonnet, Henri; Fedrigo, Enrico; Ivanescu, Liviu; Kasper, Markus E.; Paufique, Jerome

    2004-10-01

    The accurate calibration of an AO system is fundamental in order to reach the top performance expected from design. To improve this aspect, we propose procedures for calibrating a curvature AO system in view of optimizing performances and robustness, based on the experience accumulated by the ESO AO team through the development of MACAO systems for VLTI and SINFONI. The approach maximizes the quality of the Interaction Matrix (IM) while maintaining the system in its linear regime and minimizing noise and bias on the measurement.

  10. Ciências Humanas e Sociais: ciências moles? A propósito do trabalho científico nesta contemporaneidade

    Directory of Open Access Journals (Sweden)

    Maria Adélia Aparecida de Souza

    2011-08-01

    Full Text Available Este ensaio busca atender uma velha e interminável discussão sobre uma questão que longe de ser científica é, sobretudo, política, qual seja a classificação das ciências. A Geografia tem oscilado nessas classificações: ora é uma ciência humana, social, ora é uma ciência da natureza. Este estímulo é o motivo principal da realização deste ensaio que, inspirado em uma interessante reflexão de Abraham Moles, prêmio Nobel de Matemática, quando sugere que reflitamos com seriedade científica e acadêmica sobre esse debate. Esse autor propõe corajosamente que as ciências humanas sejam elas sim consideradas “ciências duras”. Aqui é defendida a tese de que, dadas as características e dinâmicas do mundo do presente, as classificações carecem de um processo de discussão condizente com a essência do mundo de hoje, que reverte por vezes o conhecimento pré-estabelecido. Sugere-se, por exemplo, nesta perspectiva, que o espaço geográfico, por ser uma instância social, tal como a economia, a política e a cultura, seja considerado uma categoria social de análise e não um palco de realização da vida, como tem sido considerado pela geografia descritiva, completamente ultrapassada pela velocidade do mundo e pelos sistemas técnicos disponíveis.

  11. Whacking a mole-cule: clinical activity and mechanisms of resistance to third generation EGFR inhibitors in EGFR mutated lung cancers with EGFR-T790M.

    Science.gov (United States)

    Costa, Daniel B; Kobayashi, Susumu S

    2015-12-01

    Epidermal growth factor receptor (EGFR) mutations, especially EGFR-exon 19 deletions and EGFR-L858R, are the most frequent actionable genomic events in lung adenocarcinomas. Tumors arise due to constitutively activated EGFR signaling and are susceptible to EGFR tyrosine kinase inhibitors (TKIs). First generation EGFR TKIs (gefitinib and erlotinib) and the second generation EGFR TKI afatinib are approved worldwide. Although targeted therapies against EGFR mutants induce dramatic initial responses, acquired resistance (through multiple biological mechanisms) to erlotinib, gefitinib and afatinib emerges within the first 1-2 years of continued monotherapy. EGFR-T790M accounts for more than half of acquired resistance to first or second generation EGFR TKIs by modifying ATP affinity and drug binding kinetics. Two new studies have shown that two covalent pyrimidine inhibitors-AZD9291 and rociletinib of EGFR-T790M (i.e., third generation EGFR TKIs) shown remarkable clinical activity in patients with acquired resistance to erlotinib, gefitinib and afatinib when the tumor carries EGFR-T790M in conjunction with an activating mutation. However, and regrettably, acquired resistance to these third generation EGFR TKIs has already been reported in preclinical models and clinical specimens; such as a tertiary mutation at EGFR-C797S that prevents covalent binding of EGFR TKIs. The experience with sequential EGFR TKI monotherapy highlights tumor heterogeneity and adaptability (i.e., relentless game of whack-a-mole played between TKIs and cancer), and will help shape future clinical development of novel combinatory approaches to manage EGFR mutated lung adenocarcinomas. PMID:26798593

  12. Estimating surface CO2 fluxes from space-borne CO2 dry air mole fraction observations using an ensemble Kalman Filter

    Directory of Open Access Journals (Sweden)

    S. Dance

    2008-11-01

    Full Text Available We have developed an ensemble Kalman Filter (EnKF to estimate 8-day regional surface fluxes of CO2 from space-borne CO2 dry-air mole fraction observations (XCO2 and evaluate the approach using a series of synthetic experiments, in preparation for data from the NASA Orbiting Carbon Observatory (OCO. The 32-day duty cycle of OCO alternates every 16 days between nadir and glint measurements of backscattered solar radiation at short-wave infrared wavelengths. The EnKF uses an ensemble of states to represent the prior error covariance to estimate 8-day CO2 surface fluxes over 144 geographical regions. We use a 12×8-day lag window, recognising that XCO2 measurements include surface flux information from prior time windows. The observation operator that relates surface CO2 fluxes to atmospheric distributions of XCO2 includes: a the GEOS-Chem transport model that relates surface fluxes to global 3-D distributions of CO2 concentrations, which are sampled at the time and location of OCO measurements that are cloud-free and have aerosol optical depths 2 profiles to XCO2, accounting for differences between nadir and glint measurements, and the associated scene-dependent observation errors. We show that OCO XCO2 measurements significantly reduce the uncertainties of surface CO2 flux estimates. Glint measurements are generally better at constraining ocean CO2 flux estimates. Nadir XCO2 measurements over the terrestrial tropics are sparse throughout the year because of either clouds or smoke. Glint measurements provide the most effective constraint for estimating tropical terrestrial CO2 fluxes by accurately sampling fresh continental outflow over neighbouring oceans. We also present results from sensitivity experiments that investigate how flux estimates change with 1 bias and unbiased errors, 2 alternative duty cycles, 3 measurement density and correlations, 4 the spatial resolution of estimated flux estimates, and 5 reducing the length of the lag window

  13. Microhabitat types promote the genetic structure of a micro-endemic and critically endangered mole salamander (Ambystoma leorae of Central Mexico.

    Directory of Open Access Journals (Sweden)

    Armando Sunny

    Full Text Available The reduced immigration and emigration rates resulting from the lack of landscape connectivity of patches and the hospitality of the intervening matrix could favor the loss of alleles through genetic drift and an increased chance of inbreeding. In order for isolated populations to maintain sufficient levels of genetic diversity and adapt to environmental changes, one important conservation goal must be to preserve or reestablish connectivity among patches in a fragmented landscape. We studied the last known population of Ambystoma leorae, an endemic and critically threatened species. The aims of this study were: (1 to assess the demographic parameters of A. leorae and to distinguish and characterize the microhabitats in the river, (2 to determine the number of existing genetic groups or demes of A. leorae and to describe possible relationships between microhabitats types and demes, (3 to determine gene flow between demes, and (4 to search for geographic locations of genetic discontinuities that limit gene flow between demes. We found three types of microhabitats and three genetically differentiated subpopulations with a significant level of genetic structure. In addition, we found slight genetic barriers. Our results suggest that mole salamander's species are very sensitive to microhabitat features and relatively narrow obstacles in their path. The estimates of bidirectional gene flow are consistent with the pattern of a stepping stone model between demes, where migration occurs between adjacent demes, but there is low gene flow between distant demes. We can also conclude that there is a positive correlation between microhabitats and genetic structure in this population.

  14. Tunable diode laser absorption spectroscopy-based tomography system for on-line monitoring of two-dimensional distributions of temperature and H{sub 2}O mole fraction

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Lijun, E-mail: lijunxu@buaa.edu.cn; Liu, Chang; Jing, Wenyang; Cao, Zhang [School of Instrument Science and Opto-Electronic Engineering, Beihang University, Beijing 100191 (China); Ministry of Education’s Key Laboratory of Precision Opto-Mechatronics Technology, Beijing 100191 (China); Xue, Xin; Lin, Yuzhen [School of Energy and Power Engineering, Beihang University, Beijing 100191 (China)

    2016-01-15

    To monitor two-dimensional (2D) distributions of temperature and H{sub 2}O mole fraction, an on-line tomography system based on tunable diode laser absorption spectroscopy (TDLAS) was developed. To the best of the authors’ knowledge, this is the first report on a multi-view TDLAS-based system for simultaneous tomographic visualization of temperature and H{sub 2}O mole fraction in real time. The system consists of two distributed feedback (DFB) laser diodes, a tomographic sensor, electronic circuits, and a computer. The central frequencies of the two DFB laser diodes are at 7444.36 cm{sup −1} (1343.3 nm) and 7185.6 cm{sup −1} (1391.67 nm), respectively. The tomographic sensor is used to generate fan-beam illumination from five views and to produce 60 ray measurements. The electronic circuits not only provide stable temperature and precise current controlling signals for the laser diodes but also can accurately sample the transmitted laser intensities and extract integrated absorbances in real time. Finally, the integrated absorbances are transferred to the computer, in which the 2D distributions of temperature and H{sub 2}O mole fraction are reconstructed by using a modified Landweber algorithm. In the experiments, the TDLAS-based tomography system was validated by using asymmetric premixed flames with fixed and time-varying equivalent ratios, respectively. The results demonstrate that the system is able to reconstruct the profiles of the 2D distributions of temperature and H{sub 2}O mole fraction of the flame and effectively capture the dynamics of the combustion process, which exhibits good potential for flame monitoring and on-line combustion diagnosis.

  15. High specific activity N-Acetyl-3{sup H}-{alpha}-Aspartyl- L-Glutamic at micro mole scale; Sintesis de N-Acetil-3{sup H}- {alpha} -Aspartil-Glutamico a escala de Micromoles

    Energy Technology Data Exchange (ETDEWEB)

    Suarez, C.

    1984-07-01

    High specific activity N-Acetyl-3{sup H}- {alpha} -Aspartyl-I-Glutamic acid at micro mole scale in prepared acetylating L- {alpha} -Aspartyl-L-glutamic with 3{sup H}-acetic anhydride in re distilled toluene. The product le purified through cationic and anionic columns. The radiochemical purity as determined by thin-layer chromatography is greater then 99% at the time preparation. (Author) 5 refs.

  16. Hammering beneath the surface of Mars – Modeling and simulation of the impact-driven locomotion of the HP3-Mole by coupling enhanced multi-body dynamics and discrete element method

    OpenAIRE

    Lichtenheldt, Roy; Schäfer, Bernd; Krömer, Olaf

    2014-01-01

    As the formation of the rocky planets in our inner solar system has always been a major subject of scientific interest, NASA’s discovery mission InSight (Interior Seismic Investigations, Geodesy and Heat Transport) intends to gain further knowledge about the interior structure of Mars. In order to understand the processes that lead to planetary evolution, Mars’ seismic as well as thermal properties will be measured. DLR’s HP3-Mole (Heat Flow and Physical Properties Package), an innovative sel...

  17. Influence of Anion and Mole Ratio on the Coordination Behavior of an NO2S3-Macrocycle: The Formation of a Dumbbell-Shaped Macrocyclic Cadmium(II) Iodide Complex.

    Science.gov (United States)

    Lee, Hyeong-Hwan; Lee, Eunji; Ju, Huiyeong; Kim, Seulgi; Park, In-Hyeok; Lee, Shim Sung

    2016-03-01

    Anion and mole ratio dependent formations of cadmium(II) complexes with an NO2S3-macrocycle (L) incorporating a pyridine subunit are reported. When the cadmium(II) salts (1-10 equiv) with different halide ions (Br(-) or I(-)) were reacted with L, CdBr2 afforded a monomer complex, [Cd(L)Br]2[Cd2Br6]·CH2Cl2 (1), with three separated parts in the whole mole ratio range: two 1:1 stoichiometric complex cation parts and one Cd2Br6 cluster anion part. After separation of 1 by filtration, [Cd(L)Br]2[CdBr4]·CH2Cl2 (2) with similar composition was afforded, except the cluster was isolated from the filtrate. Unlike the CdBr2 complexation, CdI2 afforded the mole ratio dependent products (3-5). Below 2.5 equiv of CdI2, [Cd(L)I]2[CdI4]·CH2Cl2 (3) and [Cd(L)I]2[Cd2I6]·0.5CH2Cl2 (4) with different cadmium(II) iodide clusters were isolated as kinetic (3) and a thermodynamic (4) products. Notably, the use of 3 equiv or above amount of CdI2 gave a dumbbell-shaped complex, {[Cd(L)]2(μ-Cd4I12)} (5), in which two mononuclear macrocyclic complex units are linked by a (μ-Cd4I12)(4-) cluster. To monitor the mole ratio dependency as well as their reactivities, the systematic powder X-ray diffraction (PXRD) analysis has also been applied. PMID:26900712

  18. Das montanhas mexicanas ao ciberespaço

    Directory of Open Access Journals (Sweden)

    Pedro Henrique Falco Ortiz

    2005-12-01

    Full Text Available ESTE ARTIGO faz uma apanhado histórico contextualizado e uma análise comunicacional sobre o Exército Zapatista de Libertação Nacional - EZLN, que apareceu publicamente no estado mexicano de Chiapas em janeiro de 1994, a partir de sua origem indígena, com as demandas seculares dessa parcela da população marginalizada, suas peculiaridades e sua prática política, que o fazem um grupo armado bastante original dentro do contexto das lutas populares na América Latina. As estratégias políticas e de comunicação do EZLN são diferenciais importantes em relação a outras experiências guerrilheiras anteriores. Assim, analisamos também a habilidade que os zapatistas tiveram - e ainda têm - para conquistar espaço nos meios de comunicação convencionais e criar uma eficiente rede de solidariedade e comunicação, combinando as tradições seculares das comunidades indígenas, que são suas bases, aos recursos tecnológicos de meios eletrônicos como a Internet e a Web. Esta combinação criativa de iniciativas políticas bem-sucedidas, bases sociais resistentes, diálogo permanente com a chamada sociedade civil - nacional e internacional - e vitórias importantes no campo da comunicação, compensam a fragilidade militar do EZLN e possibilitam sua continuidade, mesmo no contexto militar bastante adverso em que se situa o conflito chiapaneco.THE PRESENT article is an historical and contextualized communicational analisis on the Zapatista National Liberation Army - EZLN, that came to light the first time on january,1994, in the mexican southern state of Chiapas, with its indigenous origin, ancient struggles of the marginalized population, its own culture and political praxis that made it a very particular social movement in the context of Latin America. The polictical and communication strategies of the EZLN are important changes when we compare it to other guerrilla movements. We also analize the hability and creativity the zapatistas have

  19. Potencialidades e espaços ao empreendedorismo

    Directory of Open Access Journals (Sweden)

    Adriano Lago

    2008-01-01

    Full Text Available A criação de negócios é apontada como uma das causas da prosperidade de um local, região, estado ou de um país. É neste sentido que o empreendedorismo tem recebido destaque nos últimos anos, como promotor de novos negócios. Captar, descrever e analisar o fenômeno do empreendedorismo é, portanto, necessário para o desenho de ações de promoção do desenvolvimento. Assim, o presente estudo aborda o empreendedorismo na piscicultura, tomando como base três casos analisados: uma propriedade com rizipiscicultura, uma com piscicultura de ciclo completo inclusive com frigorífico, e outra onde a piscicultura desenvolve-se através de um pesque-pague, com vistas a proporcionar o turismo rural. Para fins de pesquisa, entrevistaram-se os proprietários de cada estabelecimento na busca dos dados necessários para a construção de uma abordagem consistente da temática proposta, ou seja, identificar a presença do empreendedorismo e suas características particulares em cada propriedade analisada. Verificou-se que determinadas características empreendedoras são comuns aos três casos analisados: habilidade para identificar oportunidades; busca de conhecimento de sua área de atuação; senso de organização; disposição para tomar decisões; capacidade de liderança; talento para empreender; otimismo e tino empresarial; ser estrategista, além do dinamismo. Portanto, foi possível observar que o perfil empreendedor dos proprietários de cada negócio tornou possível a transformação de idéias e problemas em oportunidades reais de negócio.Abstract The business opening is indicated as one of the prosperity causes of a country, state, region or local. It’s in this context that the entrepreneurship has received attention along the last years as new business promoter. This way, to study and promote development actions it’s necessary, firstly, to get, to describe and to analyze the entrepreneurship phenomenon by itself. So, this study

  20. LDEF (Prelaunch), AO201 : Interplanetary Dust Experiment, Tray B12

    Science.gov (United States)

    1984-01-01

    LDEF (Prelaunch), AO201 : Interplanetary Dust Experiment, Tray B12 The prelaunch photograph shows the six (6) inch deep Interplanetary Dust Experiment (IDE) master control tray. The tray has three (3) mounting/cover plates elevated on fiberglass stand-offs to provide clearance and protection for hardware and electronics located underneath. The stand-offs also raise the plates to a level that minimizes shading of detectors by the tray sidewalls. The mounting plate located at the left hand end of the tray is populated with eighty (80) metaloxide-silicon (MOS) capacitor-type impact sensors and one (1) solar sensor that is located approximately in the center of the mounting plate. The IDE sensors are two (2) inch diameter MOS capacitor structures approximately 250 um thick. The detectors are formed by growing either 0.4um or 1.0um thick silicon oxide, SiO2, layer on the 250um thick, B-doped polished silicon wafer. The top metal contact, the visible surface, was formed by vapor deposition of 1000A of aluminum on the SiO2 surface. Aluminum was also vapor deposited on the backside to form the contact with the silicon substrate. Gold wires are bonded to the front and back aluminum layers for use in connecting the detectors to the circuits. The complete wafers, IDE detectors, are mounted on chromic anodized aluminum frames by bonding the detector backside to the aluminum frame with a space qualified RTV silicon adhesive, de-volatized RTV-511. The difference in colors of the detectors is caused by reflections in the metallized surfaces. A reflection of one of the technicians is visible in the three (3) rows of detector on the left hand side of the mounting plate. The solar sensor, located at the mounting plate center, consist of four (4) silicon solar cells connected in series and associated circuity bonded to an aluminum baseplate. The solar sensor registered each orbital sunrise independant of LDEF orientation at the time of sunrise. When IDE solar sensor data from the six

  1. Safety evaluation of pectin-derived acidic oligosaccharides (pAOS): Genotoxicity and sub-chronic studies

    NARCIS (Netherlands)

    Garthoff, J.A.; Heemskerk, S.; Hempenius, R.A.; Lina, B.A.R.; Krul, C.A.M.; Koeman, J.H.; Speijers, G.J.A.

    2010-01-01

    Pectin-derived acidic oligosaccharides (pAOS) are non-digestible carbohydrates to be used in infant formulae and medical nutrition. To support its safety, the genotoxic potential of pAOS was evaluated. pAOS was not mutagenic in the Ames test. Positive results were obtained in the chromosome aberrati

  2. Attitude toward contraception and abortion among Curaçao women. Ineffective contraception due to limited sexual education?

    NARCIS (Netherlands)

    Brink, M.J.; Boersma, A.A.; Meyboom-deJong, B; Bruijn, de J.G.M.

    2011-01-01

    Background In Curaçao is a high incidence of unintended pregnancies and induced abortions. Most of the induced abortions in Curaçao are on request of the woman and performed by general practitioners. In Curaçao, induced abortion is strictly prohibited, but since 1999 there has been a policy of conni

  3. Transformaçao organizacional e práticas inovadoras de gestao humana

    OpenAIRE

    Calderón Hernández, Gregorio; Cuartas Castaño, Juliana; Alvarez Giraldo, Claudia Milena

    2011-01-01

    Este é um artículo de revisao que faz parte de um projeto de investigaçao denominado "Observatorio de práticas inovadoras de gestao humana na Colombia",  no qual trata-se de estabelecer um suporte teórico para as transformalçoes organizacionais e sua relaçao com a gestao humana. Aborda-se esta temática pela importancia crescente da mudança e em especial da mudança profunda que implica uma transformalçao em aspectos centrais das empresas, tais como a inovaçao, o desempenho, a competitividade e...

  4. Ciberespaço cubano: uma forma de resistência ao poder e à censura

    Directory of Open Access Journals (Sweden)

    Lia Hecker Luz

    2011-01-01

    Full Text Available A entrada do corpo e da vida nos cálculos do poder corresponde ao que Foucault chamou de biopolítica. Entretanto, o próprio Foucault intuiu que aquilo mesmo que o poder investia – a vida – era o que doravante ancoraria a resistência a ele. Assim, ao poder sobre a vida deveria responder a potência da vida, capaz de operar uma resistência possível ao sequestro da vida pelo poder. Apoiando-nos no pensamento de Lévy, levantamos a hipótese, a partir da análise do blog Generación Y, de que a blogosfera cubana é uma expressão micropolítica de resistência ao poder, de biopotência da multidão.

  5. Erection and management for polar crane of Ling'ao NPP Phase II

    International Nuclear Information System (INIS)

    The thesis gives a perspective of NI polar crane situations of Ling'ao NPP Phase 2 from angles such as supply, erection management and technical requirements, erection difficulties encountered in practice and related document provision and filing. It details, by in-depth analysis, the management characteristics and practical difficulties of Ling'ao NPP Phase 2 and approaches certain resolutions and technical improvement such as the intervention of manufacturing of equipment, the way of drilling on the bracket etc. (authors)

  6. Antecedents to the Perpetration of Domestic Violence in Curaçao

    OpenAIRE

    Wijk, van, C.; Bruijn, de, M.E.

    2015-01-01

    ABSTRACT Previous international studies have found collectivism and low gender empowerment to contribute to higher domestic violence perpetration by males, compared to females. Little is known about gender differences in domestic violence perpetration prevalence in collectivist countries with high gender empowerment, for example Curaçao. Curaçao demonstrates gender similarity in committing domestic violence, resembling Western countries: 25–33 % have committed psychological domestic violence,...

  7. Termination of Pregnancy in Curaçao: Need for Improvement of Sexual and Reproductive Healthcare

    OpenAIRE

    2012-01-01

    Background: In Curaçao Termination of Pregnancy (TOP) is still forbidden by law, although a policy of tolerance has been stipulated since 1999. This paper is about the prevalence of TOP and about its health complications. These data on TOP are officially unknown but are suspected to be rather high. Methods: One year registration of illegal performed termination of pregnancy cases by all general physicians (GPs) practicing TOP in Curaçao. The registration included patient characteristics accor...

  8. East Asian winter temperature variation associated with the combined effects of AO and WP pattern

    Science.gov (United States)

    Park, Hye-Jin; Ahn, Joong-Bae

    2016-04-01

    The combined effects of the Arctic Oscillation (AO) and Western Pacific (WP) teleconnection pattern on the East Asian winter monsoon (EAWM) over the last 56 years (1958/59-2013/2014) were investigated using NCEP/NCAR reanalysis data (Park and Ahn, 2015). The study results revealed that the effect of the AO on winter temperature in East Asia could be changed depending on the phases of the WP pattern in the North Pacific. The negative relationship between the EAWM and the AO increased when the AO and WP were in-phase with each other. Hence, when winter negative (positive) AO was accompanied by negative (positive) WP, negative (positive) temperature anomalies were dominant across the entire East Asia region. Conversely, when the AO and WP were of-of-phase, the winter temperature anomaly in East Asia did not show distinct changes. Furthermore, from the perspective of stationary planetary waves, the zonal wavenumber-2 patterns of sea level pressure and geopotential height at 500hPa circulation strengthened when the AO and WP were in-phase but were not significant for the out-of-phase condition. It explained the possible mechanism of the combined effects of the AO and WP on the circulation related to EAWM. Reference Park, H.-J., and J.-B. Ahn (2015) Combined effect of the Arctic Oscillation and the Western Pacific pattern on East Asia winter temperature, Clim. Dyn. DOI:10.1007/s00382-015-2763-2. Acknowledgements This work was funded by the Korea Meteorological Administration Research and Development Program under grant KMIPA2015-2081.

  9. Status update and closed-loop performance of the Magellan adaptive optics VisAO camera

    Science.gov (United States)

    Kopon, Derek; Close, Laird M.; Males, Jared; Gasho, Victor; Morzinski, Katie; Follette, Katherine

    2012-07-01

    We present laboratory results of the closed-loop performance of the Magellan Adaptive Optics (AO) Adaptive Secondary Mirror (ASM), pyramid wavefront sensor (PWFS), and VisAO visible adaptive optics camera. The Magellan AO system is a 585-actuator low-emissivity high-throughput system scheduled for first light on the 6.5 meter Magellan Clay telescope in November 2012. Using a dichroic beamsplitter near the telescope focal plane, the AO system will be able to simultaneously perform visible (500-1000 nm) AO science with our VisAO camera and either 10 μm or 3-5 μm science using either the BLINC/MIRAC4 or CLIO cameras, respectively. The ASM, PWS, and VisAO camera have undergone final system tests in the solar test tower at the Arcetri Institute in Florence, Italy, reaching Strehls of 37% in i'-band with 400 modes and simulated turbulence of 14 cm ro at v-band. We present images and test results of the assembled VisAO system, which includes our prototype advanced Atmospheric Dispersion Corrector (ADC), prototype calcite Wollaston prisms for SDI imaging, and a suite of beamsplitters, filters, and other optics. Our advanced ADC performs in the lab as designed and is a 58% improvement over conventional ADC designs. We also present images and results of our unique Calibration Return Optic (CRO) test system and the ASM, which has successfully run in closedloop at 1kHz. The CRO test is a retro reflecting optical test that allows us to test the ASM off-sky in close-loop using an artificial star formed by a fiber source.

  10. Effects of Dexamethasone on glucocorticoid receptor expression in a human ovarian carcinoma cell line 3AO

    Institute of Scientific and Technical Information of China (English)

    徐明娟; 宋亮年; 王昭梅

    2003-01-01

    Objective To observe the effects of Dexamethasone (Dex), a synthetic glucocorticoid, on glucocorticoid receptor expression in the human ovarian carcinoma cell line 3AO. The molecular mechanism of glucocorticoid (GC) on 3AO cells was also studied.Methods The expression and regulation of the glucocorticoid receptor in 3AO cells was studied by utilizing radioligand binding assay and quantitative RT-PCR. Results High affinity and low capacity GR existed in 3AO cells, in addition, GR binding activity was down-regulated by Dex in a time-dependent manner, to a level about 28.34% of control following 24 hours treatment, with a concomitant decrease in GR mRNA. The induction of alkaline phosphatase (AKP) activity by Dex was reversed by RU486, a potent glucocorticoid antagonist.Conclusion In 3AO cells, functional GR which can be down-regulated by Dex at the protein and mRNA level, exists suggesting that the regulating effects of Dex on GR occur at least partially at the GR mRNA level, and that the cellular effects of Dex on 3AO cells might be mediated by GR.

  11. Parameterising E-ELT AO PSFs for detailed science simulations for HARMONI

    Science.gov (United States)

    Zieleniewski, Simon; Thatte, Niranjan

    2013-12-01

    With the first ELTs around the corner it is becoming ever more important to determine observational strategies and assess the prospective success of observing programs prior to making the observations. To this end, scientific simulations need to become more refined to understand the criteria required for a specific science case. We address the science simulations for HARMONI, an AO assisted first light integral field spectrograph (IFS) for the E-ELT. AO PSFs vary markedly as a function of wavelength and type of AO system used, so there is need to create detailed PSFs across all IFS wavelength channels for accurate simulations. Detailed AO simulations have shown that for LTAO on the E-ELT, Strehl ratios can vary from 0.5E-3 in V-band up to 0.5 in K-band. Using a single PSF for an entire datacube (especially with large instantaneous wavelength coverage) could introduce misleading features into simulated observations using HARMONI. We have developed a method to parameterize detailed PSFs using analytical models, which can then be interpolated as a function of wavelength. This allows us to create accurate, but computationally inexpensive, AO PSF datacubes for HARMONI simulations. This shall be developed to cover LTAO, SCAO and GLAO/no-AO PSFs for a range of observing parameters.

  12. MagAO: Status and on-sky performance of the Magellan adaptive optics system

    CERN Document Server

    Morzinski, Katie M; Males, Jared R; Kopon, Derek; Hinz, Phil M; Esposito, Simone; Riccardi, Armando; Puglisi, Alfio; Pinna, Enrico; Briguglio, Runa; Xompero, Marco; Quirós-Pacheco, Fernando; Bailey, Vanessa; Follette, Katherine B; Rodigas, T J; Wu, Ya-Lin; Arcidiacono, Carmelo; Argomedo, Javier; Busoni, Lorenzo; Hare, Tyson; Uomoto, Alan; Weinberger, Alycia

    2014-01-01

    MagAO is the new adaptive optics system with visible-light and infrared science cameras, located on the 6.5-m Magellan "Clay" telescope at Las Campanas Observatory, Chile. The instrument locks on natural guide stars (NGS) from 0$^\\mathrm{th}$ to 16$^\\mathrm{th}$ $R$-band magnitude, measures turbulence with a modulating pyramid wavefront sensor binnable from 28x28 to 7x7 subapertures, and uses a 585-actuator adaptive secondary mirror (ASM) to provide flat wavefronts to the two science cameras. MagAO is a mutated clone of the similar AO systems at the Large Binocular Telescope (LBT) at Mt. Graham, Arizona. The high-level AO loop controls up to 378 modes and operates at frame rates up to 1000 Hz. The instrument has two science cameras: VisAO operating from 0.5-1 $\\mu$m and Clio2 operating from 1-5 $\\mu$m. MagAO was installed in 2012 and successfully completed two commissioning runs in 2012-2013. In April 2014 we had our first science run that was open to the general Magellan community. Observers from Arizona, Ca...

  13. Fatores associados ao baixo peso ao nascimento entre adolescentes no Sudeste do Brasil Factors associated with low birth weight among adolescents in the Brazil Southeast region

    Directory of Open Access Journals (Sweden)

    Fernanda Garanhani Castro Surita

    2011-10-01

    Full Text Available OBJETIVOS: Conhecer a prevalência e alguns fatores associados ao baixo peso ao nascer entre gestantes adolescentes. MÉTODOS: Estudo de corte transversal, realizado entre outubro de 1994 a dezembro de 2009, com os partos ocorridos em uma maternidade de Campinas, utilizando informações coletadas em uma Ficha Obstétrica Informatizada. Foram selecionados os casos de partos entre adolescentes e, posteriormente, separados em dois grupos com e sem baixo peso ao nascer. Foram calculados o risco relativo e o intervalo de confiança (IC de 95% para as variáveis independentes (fatores de risco, e calculou-se o teste do Χ2 para comparação dos resultados perinatais. Assumiu-se nível de significância de 5%. RESULTADOS: No período ocorreram 24.000 partos no Centro de Atenção à Saúde da Mulher (CAISM, com 2.404 em 2.357 adolescentes (10,02%, sendo a frequência de baixo peso ao nascer de 15,1%. A gestação neste grupo foi recorrente em 294 (8,2%. A idade menor que 15 anos, anemia, tabagismo e hipertensão não se associaram ao baixo peso ao nascer. O antecedente de aborto e a associação com lúpus eritematoso sistêmico elevaram o risco de baixo peso ao nascer. A necessidade de cesariana e o Apgar menor que sete também foram mais prevalentes entre as adolescentes com baixo peso ao nascer, e 85% das adolescentes realizaram menos de seis consultas durante o pré-natal. CONCLUSÕES: A prevalência de baixo peso ao nascer é maior entre as adolescentes do que na população geral. Também chamou a atenção o grande número de adolescentes com menos de seis consultas durante o pré-natal. O antecedente de aborto e a presença de lúpus eritematoso sistêmico foram fatores de risco para ocorrência de baixo peso ao nascer em gestantes adolescentes.PURPOSES: To determine the rate of low birth weight and some of the risk factors associated with this event among adolescents. METHODS: A cross-sectional study conducted between October 1994 and

  14. Modelos para o planejamento centralizado da produçao e o transporte na cadeia de suprimento: uma revisao

    OpenAIRE

    Mula, Josefa; Peidro, David; Díaz-Madronero, Manuel; JORGE E. HERNÁNDEZ

    2011-01-01

    Este artigo apresenta uma revisao bibliográfica sobre os modelos de programaçao matematica para o planejamento centralizado da produçao e a transporte em uma cadeia de suprimento. O propósito desta revisao e identificar a pesquisa atual e futura neste campo e propor um marco de classificaçao baseado nos seguintes elementos: Estrutura da cadeia de suprimento, nivel de decisao, enfoque de modelagem, propósito, informaçao intercambiada e aplicaçao pratica. O objetivo do artigo e proporcionar um ...

  15. Estimating surface CO2 fluxes from space-borne CO2 dry air mole fraction observations using an ensemble Kalman Filter

    Directory of Open Access Journals (Sweden)

    S. Dance

    2009-04-01

    Full Text Available We have developed an ensemble Kalman Filter (EnKF to estimate 8-day regional surface fluxes of CO2 from space-borne CO2 dry-air mole fraction observations (XCO2 and evaluate the approach using a series of synthetic experiments, in preparation for data from the NASA Orbiting Carbon Observatory (OCO. The 32-day duty cycle of OCO alternates every 16 days between nadir and glint measurements of backscattered solar radiation at short-wave infrared wavelengths. The EnKF uses an ensemble of states to represent the error covariances to estimate 8-day CO2 surface fluxes over 144 geographical regions. We use a 12×8-day lag window, recognising that XCO2 measurements include surface flux information from prior time windows. The observation operator that relates surface CO2 fluxes to atmospheric distributions of XCO2 includes: a the GEOS-Chem transport model that relates surface fluxes to global 3-D distributions of CO2 concentrations, which are sampled at the time and location of OCO measurements that are cloud-free and have aerosol optical depths 2 profiles to XCO2, accounting for differences between nadir and glint measurements, and the associated scene-dependent observation errors. We show that OCO XCO2 measurements significantly reduce the uncertainties of surface CO2 flux estimates. Glint measurements are generally better at constraining ocean CO2 flux estimates. Nadir XCO2 measurements over the terrestrial tropics are sparse throughout the year because of either clouds or smoke. Glint measurements provide the most effective constraint for estimating tropical terrestrial CO2 fluxes by accurately sampling fresh continental outflow over neighbouring oceans. We also present results from sensitivity experiments that investigate how flux estimates change with 1 bias and unbiased errors, 2 alternative duty cycles, 3 measurement density and correlations, 4 the spatial resolution of estimated flux estimates, and 5 reducing the length of the lag window and the

  16. Surface and bulk modifications of 1.5 mole % Sr/La{sub 2}O{sub 3} catalyst with different Co, Ni, and Cu amounts

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez Cortes, Sergio; Fontal, Bernardo [Universidad de los Andes, Merida (Venezuela); Moronta, Delfin [Universidad Central de Venezuela, Caracas (Venezuela)

    2001-08-01

    The effects of Co, Ni and Cu oxide content on the surface and bulk of the 1.5 mole % Sr/La{sub 2}O{sub 3} catalysts were studied. Series of M/Sr-La catalysts (MCo, Ni, Cu) were prepared by successive immersion impregnation. The solids were characterized by X-ray diffraction (XRD), infrared spectroscopy (FTIR), temperature-programmed reduction (TPR), electron paramagnetic resonance (EPR), specific surface area measurements (BET) and thermogravimetric analysis (TGA). The Sr/La{sub 2}O{sub 3} modified with different Co, Ni, and Cu loading shows a strong metal oxide interaction with La{sub 2}O{sub 3}. This probably begin over anionic vacancies or structure defects favoring LaSrMO{sub x} solid solution formation with island-like structures according to a Volmer-Weber growth. It is proposed that the growth mode of La-Co, La-Ni and La-Cu stoichiometric phases occur from solid solutions. The formation of only a La-M single phase, probably non-stoichiometric, increases the material porosity while different phases favor the agglomeration or sintering of the particles. [Spanish] En este trabajo se estudia el efecto de la cantidad de cobalto, niquel y cobre sobre las estructuras superficial y masica del sistema 1.5% molar Sr/La{sub 2}O{sub 3}. Los catalizadores M/Sr-La (M = Co, Ni, Cu) fueron preparados por el metodo de impregnacion con exceso de solucion. Los solidos se caracterizaron por difraccion de rayos-X, espectroscopia infrarroja con transformada de Fourier, reduccion a temperatura programada, resonancia paramagnetica del electron, medidas del area superficial especifica por el metodo de BET y analisis termogravimetrico. El catalizador Sr/La{sub 2}O{sub 3} modificado con diferentes cantidades de Co, Ni y Cu muestra una interaccion fuerte con el oxido del metal de transicion, probablemente sobre las vacancias anionicas o defectos estructurales que favorecen la formacion de la solucion solida LaSrMox en forma de isla, segun el mecanismo de crecimiento de fase de Volmer

  17. Soft tissue Rosai-Dorfman disease of the posterior mediastinum Doença de Rosai-Dorfman de partes moles no mediastino posterior

    Directory of Open Access Journals (Sweden)

    Antônio Luiz Penna Costa

    2009-07-01

    Full Text Available Rosai-Dorfman disease (RDD consists of sinus histiocytosis with massive lymphadenopathy. Extranodal involvement occurs in up to 43% of cases. However, isolated soft tissue RDD is rare. Isolated mediastinal RDD is exceedingly rare, and there have been only three previous reports. Involvement of the posterior mediastinum in RDD has been reported only in the context of disseminated RDD. Here, we report the case of a 49-year-old female patient with a two-year history of cervical pain and lymphadenomegaly, which resolved spontaneously. A CT scan revealed a left paravertebral mass with a diameter of 6 cm. The patient was submitted to surgical excision of the mass. Microscopic examination and immunophenotyping of the surgical specimen led to a diagnosis of RDD. During a 12-month follow-up period, the patient complained of mild cough and chest pain. Periodic imaging tests showed no sign of recurrence, and no postoperative cervical lymphadenomegaly was detected.A doença de Rosai-Dorfman (DRD consiste em histiocitose sinusal com linfadenopatia maciça. O envolvimento extranodal ocorre em até 43% dos casos. Entretanto, a DRD de partes moles de forma isolada é rara. A forma isolada de DRD mediastinal é muito rara, com apenas três relatos prévios. O envolvimento do mediastino posterior só foi descrito no contexto da DRD disseminada. Relatamos o caso de uma paciente de 49 anos de idade com história de dor e linfadenomegalia cervical há dois anos, com resolução espontânea. A TC revelou uma massa paravertebral à esquerda medindo 6 cm de diâmetro. A paciente foi submetida à ressecção cirúrgica da massa. O exame microscópico e estudo do imunofenótipo da peça cirúrgica definiram o diagnóstico de DRD. A paciente foi acompanhada por 12 meses, queixando-se de tosse discreta e dor torácica. O acompanhamento por imagem não detectou recorrência, e nenhuma linfadenomegalia cervical foi observada após a cirurgia.

  18. Instrumento mensurador de adesao para hipertensos: contribuicao da Teoria da Resposta ao Item

    Directory of Open Access Journals (Sweden)

    Malvina Thais Pacheco Rodrigues

    2013-06-01

    Full Text Available OBJETIVO: Analisar instrumento de medição da adesão ao tratamento da hipertensão por meio da "Teoria da Resposta ao Item". MÉTODOS: Estudo analítico com 406 hipertensos com complicações associadas, atendidos na atenção básica em Fortaleza, CE, 2011, pela "Teoria da Resposta ao Item". As etapas de execução foram: teste de dimensionalidade, calibração dos itens; tratamento dos dados e construção da escala, analisadas com base no modelo de resposta gradual. Estudo da dimensionalidade do instrumento foi feito pela análise da matriz de correlação policórica e análise fatorial de informação completa. Utilizou-se o software Multilog para calibração dos itens e estimação dos escores. RESULTADOS: Os itens referentes ao tratamento medicamentoso foram os mais diretamente relacionados à adesão, enquanto aqueles referentes ao tratamento não medicamentoso precisam ser reformulados, pois possuíram menor quantidade de informação psicométrica e baixa discriminação. A independência dos itens, o reduzido número de níveis da escala e as baixas variâncias explicadas no ajuste dos modelos mostraram as principais fragilidades do instrumento analisado. A "Teoria da Resposta ao Item" mostrou-se relevante para análise, pois avaliou o respondente quanto à adesão ao tratamento da hipertensão, ao nível de dificuldade dos itens e à sua capacidade de discriminação entre indivíduos com diferentes níveis de adesão, o que gerou maior quantidade de informação. CONCLUSÕES: O instrumento analisado é limitado para medir a adesão ao tratamento da hipertensão, mediante análise pela "Teoria da Resposta ao Item", e necessita de ajustes. A adequada formulação dos itens é importante para medir precisamente o traço latente desejado.

  19. Obstrução nasal total: estudo morfofuncional de um caso de sinéquia de palato mole e paredes faríngeas pós blastomicose Total nasal obstruction: a morphofunctional case study of post blastomicose palato and pharynx's lesion

    Directory of Open Access Journals (Sweden)

    Camila Queiroz de Moraes Silveira Di Ninno

    2012-10-01

    Full Text Available TEMA: identificar as alterações morfofuncionais decorrentes de quinze anos de obstrução nasal total em um caso de sinéquia de palato mole e paredes faríngeas pós blastomicose. PROCEDIMENTOS: o trabalho foi baseado no estudo de caso de um adulto do gênero feminino, de 26 anos de idade, que chegou a um centro especializado em deformidades craniofaciais, com a queixa de não conseguir respirar pelo nariz. Sua dificuldade respiratória é decorrente de uma aderência total do palato mole com as paredes faríngeas, como sequela da blastomicose que teve no palato aos 11 anos de idade. RESULTADOS: na entrevista, a paciente relatou queixa de cefaléia, halitose, pouco rendimento físico, sonolência diurna e sono agitado durante a noite. Referiu também anosmia, mastigação lenta e engasgos frequentes. Durante a avaliação, observou-se respiração exclusivamente oral do tipo superior, mastigação bilateral alternada e lenta, deglutição adaptada e ressonância hiponasal de grau grave. Observou-se ainda face longa, perfil convexo, mandíbula retruída e olheiras. Os lábios da paciente encontravam-se entreabertos e ressecados, sendo o superior fino e o inferior evertido e avolumado e o palato duro apresenta-se atrésico, estreito e profundo. CONCLUSÃO: as características da paciente em questão são compatíveis com a Síndrome do Respirador Oral e pode-se supor que sejam consequências morfofuncionais de uma obstrução nasal total.BACKGROUND: to identify the consequences that arising from fifteen years of total nasal obstruction in a case of post blastomicose palato and pharynx's lesion. PROCEDURES: this article was based on a case report of a 26-years-old female subject, who came to a specialized center on craniofacial deformities, complaining about her mouth breathing. Her respiratory difficulty stems from a total tack of palate and pharynx, as a blastomicose sequel that she had when 11-year-old. RESULTS: during the interview, the

  20. Morfologia e Crescimento dos 6 aos 10 anos de idade em Viana do Castelo, Portugal

    Directory of Open Access Journals (Sweden)

    Luis Paulo Rodrigues

    2008-09-01

    Full Text Available Ao longo de quatro anos, o Estudo Morfofuncional da Criança Vianense observou 1911 crianças entre os 6e os 10 anos de idade, resultando em 4064 observações individuais(2054 de raparigas, 2006 de rapazes.Os resultados encontrados nos indicadores morfológicos simples(altura, peso, pregas adiposas, diâmetros ósseos e perímetros muscularese no somatótipo, são descritos normativamente (valores percentílicose comparados com outros estudos nacionais e internacionais. As crianças vianenses demonstraram possuir uma estatura média ligeiramente superior às reportadas nos estudos portugueses e um ritmo de crescimento diferente das norte-americanas; peso semelhante ao das congéneres nacionais mas inferior ao das EUA; valores de pregas adiposas geralmente inferiores aos encontrados em Portugal e EUA; perímetros musculares e diâmetros ósseos semelhantes aos seus pares portugueses; e uma tendência para o aumento, com a idade, do ectomorfismo nos rapazes e do endomorfismo em ambos os sexos. Este panorama parece indicar que as crianças vianenses apresentam características de aptidão morfologia que estão longe de espelhar as preocupações internacionais nesta matéria.

  1. Significant relationship between spring AO and the summer rainfall along the Yangtze River

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The influence of spring AO on the summer rainfall along the Yangtze River is investigated. The long-term rainfall observations are filtered to remove the low-frequency variations longer than 10 years. The inter-annual components show a high correlation to AO in the last hundred years. The strongest correlation appears for May AO and summer rainfall with a value of ?0.39, significant above the 99% confidence level. Associated with one standard deviation stronger May AO index, the rainfall over the Yangtze River to the southern Japan decreases by about 3%-9%, while, at the same time increases by about 3%-6% in the northern China and far-eastern Russia. The coherent changes in rainfall are significantly related to the East Asian summer jet stream in the upper troposphere. When there is stronger AO in spring, the jet stream tends to move polarward in summer, and leads the rainfall-belt to move northward too. That gives rise to a drier condition in the Yangtze River valley, wetter anomalies in northern China. This signal would be helpful for the summer rainfall prediction in China.

  2. First light AO system for LBT: toward on-sky operation

    Science.gov (United States)

    Esposito, S.; Tozzi, A.; Puglisi, A.; Pinna, E.; Riccardi, A.; Busoni, S.; Busoni, L.; Stefanini, P.; Xompero, M.; Zanotti, D.; Pieralli, F.

    2006-06-01

    The paper is describing the present status of the LBT first light AO system. The system design started in January 2002 and is now approaching the final test in the Arcetri solar tower. Two key features of this single conjugate AO system are the use of an adaptive secondary mirror having 672 actuators and a pyramid wavefront sensor with a maximum sampling of 30x30 subapertures. The paper is reporting about the adaptive secondary mechanical electrical and optical integration, and the wavefront sensor unit integration and acceptance test. Finally some lab test of the AO system done using an adaptive secondary prototype with 45 actuators, the so called P45 are described. The aim of these test was to get an estimate of the system limiting magnitude and to demonstrate the feasibility of a new technique able to measure AO system interaction matrix in a shortest time and with higher SNR with respect to the classical interaction matrix measurement. We are planning to use such a technique to calibrate the AO system in Arcetri and later at the LBT telescope.

  3. Doença periodontal materna como fator associado ao baixo peso ao nascer Maternal periodontal disease as a factor associated with low birth weight

    OpenAIRE

    Simone Seixas da Cruz; Maria da Conceição N. Costa; Isaac Suzart Gomes Filho; Maria Isabel P. Vianna; Carlos Teles Santos

    2005-01-01

    OBJETIVO: Estudos recentes têm apresentado evidências de que a doença periodontal em gestantes pode ser um dos determinantes do baixo peso ao nascer. Realizou-se estudo para verificar a existência de associação entre doença periodontal materna e baixo peso ao nascer. MÉTODOS: Estudo do tipo caso-controle com 302 mulheres, sendo 102 mães de nascidos vivos de baixo peso (grupo caso) e 200 mães de nascidos vivos com peso normal (grupo controle). A existência de associação entre doença periodonta...

  4. A Arqueologia do cuidado: da prática ao discurso

    Directory of Open Access Journals (Sweden)

    Sidi Askofare

    2006-06-01

    Full Text Available A noção de cuidado, assimilada há muito tempo ao tratamento e, então, ao conceito de terapêutica, retorna, logo depois, nos estudos, pesquisas e reflexões nas ciências humanas. Mas, daí em diante, está emancipado de suas aderências e conotações médicas por serem demasiadamente redutoras. O presente artigo propõe uma arqueologia (no sentido foucaultiano do cuidado &– de suas origens animais às suas formas culturalmente e historicamente definidas &– e põe em evidência a subversão que produz no campo do cuidado &– das práticas aos discursos &– a emergência e a dominação do discurso da ciência.

  5. A utilizaçao de módulos de ensino como metodologia para a mudança de conceito e atitudes de alunos do curso de habilitaçao ao magistério com relaçao a Ciencias e ao seu ensino

    OpenAIRE

    Barra, Vilma Marcassa

    1982-01-01

    Resumo: Inúmeras pesquisas já foram realizadas com a finalidade de avaliar os resultados da utilização de módulos de ensino na comunicação de informações teóricas. Este estudo, porem, não pretendeu avaliar tais resultados, mas sim verificar se uma determinada metodologia do ensino de Ciências pode ser proposta através de módulos de ensino e apreendida dessa forma pelas alunas do curso de Habilitação ao Magistério, em nível de 29 graus. A metodologia aqui tratada tem como pontos básicos: o uma...

  6. Deep-water sponges (Porifera) from Bonaire and Klein Curaçao, Southern Caribbean.

    Science.gov (United States)

    Soest, Rob W M Van; Meesters, Erik H W G; Becking, Leontine E

    2014-01-01

    Four submersible dives off the coast of Bonaire (Caribbean Netherlands) and Klein Curaçao (Curaçao) to depths of 99.5-242 m, covering lower mesophotic and upper dysphotic zones, yielded 52 sponge specimens belonging to 31 species. Among these we identified 13 species as new to science. These are Plakinastrella stinapa n. sp., Pachastrella pacoi n. sp., Characella pachastrelloides n. sp., Geodia curacaoensis n. sp., Caminus carmabi n. sp., Discodermia adhaerens n. sp., Clathria (Microciona) acarnoides n. sp., Antho (Acarnia) pellita n. sp., Parahigginsia strongylifera n. sp., Calyx magnoculata n. sp., Neopetrosia dutchi n. sp., Neopetrosia ovata n. sp. and Neopetrosia eurystomata n. sp. We also report an euretid hexactinellid, which belongs to the rare genus Verrucocoeloidea, recently described (2014) as V. liberatorii Reiswig & Dohrmann. The remaining 18 already known species are all illustrated by photos of the habit, either in situ or 'on deck', but only briefly characterized in an annotated table to confirm their occurrence in the Southern Caribbean. The habitat investigated-steep limestone rocks, likely representing Pleistocene fossil reefs-is similar to deep-water fossil reefs at Barbados of which the sponges were sampled and studied by Van Soest and Stentoft (1988). A comparison is made between the two localities, showing a high degree of similarity in sponge composition: 53% of the present Bonaire-Klein Curaçao species were also retrieved at Barbados. At the level of higher taxa (genera, families) Bonaire-Klein Curaçao shared approximately 80% of its lower mesophotic and upper dysphotic sponge fauna with Barbados, despite a distance between them of 1000 km, indicating high faunal homogeneity. We also preliminarily compared the shallow-water (euphotic) sponge fauna of Curaçao with the combined data available for the Barbados, Bonaire and Klein Curaçao mesophotic and upper dysphotic sponges, which resulted in the conclusion that the two faunas show only

  7. Characterization of phosphorus removal bacteria in (AO)2 SBR system by using different electron acceptors

    Institute of Scientific and Technical Information of China (English)

    JIANG Yi-feng; WANG Lin; YU Ying; WANG Bao-zhen; LIU Shuo; SHEN Zheng

    2007-01-01

    Characteristics of phosphorus removal bacteria were investigated by using three different types of electron acceptors, as well as the positive role of nitrite in phosphorus removal process. An (AO)2 SBR (anaerobic-aerobic-anoxic-aerobic sequencing batch reactor) was thereby employed to enrich denitrifying phosphorus removal bacteria for simultaneously removing phosphorus and nitrogen via anoxic phosphorus uptake. Ammonium oxidation was controlled at the first phase of the nitrification process. Nitrite-inhibition batch tests illustrated that nitrite was not an inhibitor to phosphorus uptake process, but served as an alternative electron acceptor to nitrate and oxygen if the concentration was under the inhibition level of 40mg NO2 - N · L- 1. It implied that in addition to the two well-accepted groups of phosphorus removal bacterium ( one can only utilize oxygen as electron acceptor, P1, while the other can use both oxygen and nitrate as electron acceptor, P2 ), a new group of phosphorus removal bacterium P3, which could use oxygen, nitrate and nitrite as electron acceptor to take up phosphorus were identified in the test system. To understand (AO)2 SBR sludge better, the relative population of the different bacteria in this system, plus another A/O SBR sludge (seed sludge) were respectively estimated by the phosphorus uptake batch tests with either oxygen or nitrate or nitrite as electron acceptor. The results demonstrated that phosphorus removal capability of (AO)2 SBR sludge had a little degradation after A/O sludge was cultivated in the (AO)2 mode over a long period of time. However, denitrifying phosphorus removal bacteria ( P2 and P3 ) was significantly enriched showed by the relative population of the three types of bacteria,which implied that energy for aeration and COD consumption could be reduced in theory.

  8. Alternativas de controle pós-colheita da podridão-parda e da podridão-mole em frutos de pessegueiro Alternatives for post-harvest control of brown rot and soft rot in peach fruits

    OpenAIRE

    Vicente Luiz de Carvalho; Rodrigo Luz da Cunha; Nilton Nagib Jorge Chalfun; Pedro Henrique Abreu Moura

    2009-01-01

    As exigências do consumidor são cada vez maiores com relação à qualidade de produtos in natura. As podridões, além de causar perdas na produção, reduzem a qualidade final do fruto, interferindo significativamente na comercialização. Objetivou-se, com este trabalho, avaliar a eficiência de produtos alternativos, aplicados na pós-colheita, no controle da podridão-parda (Monilinia fructicola) e da podridão-mole (Rhizopus spp.) em pêssegos. O experimento foi conduzido no município de Nepomuceno-M...

  9. Non-ideality of methanol solution's of artificial serum in the mole fraction range from 5 x 10(-4) to 5 x 10(-3) at 25 degrees C

    DEFF Research Database (Denmark)

    Ralloff, K.P.G.; Westh, Peter; Purssell, R.A.;

    2003-01-01

    Vapour pressure and excess partial molar enthalpy were measured at 25 degreesC for solutions of methanol in H2O and artificial serum solutions. The mole fraction range studied was from 5 x 10(-4) to 5 x 10(-3). From the vapour pressure data, the partial pressures were determined by the Barker's and...... Boissonnas' methods. Various thermodynamic functions were then calculated from them. The curve-fitting (Barker's method) gave the osmotic coefficients very close to unity in all the cases, including serum solutions. The purely numerical method without resorting to any fitting function (Boissonnas' method...

  10. Obtenção de plantas de feijão-caupi resistentes ao Cowpea severe mosaic virus e ao Cowpea aphid-borne mosaic virus

    Directory of Open Access Journals (Sweden)

    Gislanne Brito Barros

    2013-06-01

    Full Text Available Dentre os vírus que infectam o feijão-caupi (Vigna unguiculata L. Walp. destacam-se, respectivamente, pela severidade e ampla ocorrência o Cowpea severe mosaic virus (CPSMV e o Cowpea aphid-borne mosaic virus (CABMV. Portanto, objetivaram-se, no presente trabalho, obter e avaliar plantas de feijão-caupi com resistência ao CPSMV e ao CABMV, visando ao desenvolvimento de cultivares essencialmente derivadas e novas cultivares. Realizaram-se oito cruzamentos seguidos de retrocruzamentos, utilizando a linhagem TE 97-309G-9 e a cultivar Patativa como genitores resistentes, e as cultivares BR3-Tracuateua, BRS-Urubuquara, BRS-Novaera, BRS-Guariba e Pretinho como genitores suscetíveis. As gerações F2 e F2RC1 foram desafiadas quanto à resistência por meio de inoculação mecânica com isolados do CPSMV e do CABMV. Nas gerações F2RC1, além da resistência foram avaliados os caracteres: número de dias para o início da floração, comprimento das vagens, número de grãos. vagem-1, peso de cem grãos e produção de grãos.planta-1. Todos os indivíduos F2 e F2RC1 foram analisados pelo teste χ² e se ajustaram à frequência esperada de 15 plantas suscetíveis 1 planta resistente a ambos os vírus. As médias das plantas F2RC1 resistentes, de cada retrocruzamento, foram comparadas com a média do seu respectivo genitor recorrente pelo teste 't' e as médias dos retrocruzamentos foram comparadas pelo teste de Scott-Knott. Foi detectada variabilidade genética entre os retrocruzamentos para todos os caracteres. Todos os retrocruzamentos foram considerados promissores para produção de cultivares essencialmente derivadas resistentes ao CPSMV e ao CABMV e as plantas selecionadas possuem características que possibilitam a seleção de linhagens com grãos de bom padrão comercial e altamente produtivas.

  11. Dynamic SPECT of the brain using a lipophilic technetium-99m complex, PnAO

    DEFF Research Database (Denmark)

    Holm, S; Andersen, A R; Vorstrup, S;

    1985-01-01

    The lipophilic 99mTc-labeled oxime propylene amine oxime (PnAO) should, according to recent reports behave like 133Xe in the human brain. This study compares SPECT images of the two tracers in six subjects: four stroke cases, one transitory ischemic attack case and one normal subject. Technetium-99...... cerebral blood flow followed by rapid washout. In the stroke cases, low flow areas were equally well visualized by both tracers. Two dissimilarities were seen in the initial pictures: PnAO visualized the cerebral veins and showed a lesser contrast of gray:white matter uptake. The results suggest that Pn...

  12. The Ashkenazi Jews of Curaçao, a trading minority

    Directory of Open Access Journals (Sweden)

    Eva Abraham-Van der Mark

    2000-07-01

    Full Text Available First describes the early Sephardi presence in Curaçao, the arrival of the Ashkenazi in the 20th c., and the relations between these 2 groups. Author goes on to discuss the Ashkenazis' economic success and the exodus of the 1980s. She asks whether the success and the exodus can be attributed to the characteristics of the group itself or whether conditions and developments in Curaçao account for economic fortune and the departure of the Ashkenazi.

  13. The CfAO's Astronomy Course in COSMOS: Curriculum Design, Rationale, and Application

    OpenAIRE

    Cooksey, Kathy L.; Seagroves, Scott; Porter, Jason; Raschke, Lynne; Severson, Scott; Hinkley, Sasha

    2010-01-01

    From 2001 to 2007, COSMOS provided a teaching and outreach venue for the Center for Adaptive Optics Professional Development Program (CfAO PDP). COSMOS is a four-week residential mathematics and science summer program for high-school students organized by the University of California on four of its campuses. Two topical science courses comprised each COSMOS cluster. An astronomy course has always formed a basis for the CfAO PDP-affiliated cluster. The course included a variety of pedagogical ...

  14. Ressalto no canto posteromedial do joelho relacionado ao músculo sartório

    Directory of Open Access Journals (Sweden)

    Marcello Henrique Nogueira-Barbosa

    2011-06-01

    Full Text Available As causas da síndrome de ressalto no joelho relatadas com maior frequência são relacionadas a anormalidades meniscais, ao tendão do músculo bíceps femoral e aos tendões grácil e semitendíneo. Neste trabalho é descrito um caso de ressalto no canto posteromedial relacionado à junção miotendínea do músculo sartório em um paciente do sexo masculino, de 58 anos de idade, com hiperextensão do joelho.

  15. O direito penal na regulaçao da vida e da morte ante a biotecnologia

    OpenAIRE

    Minahim, Maria Auxiliadora

    2005-01-01

    A sociedade pós-industrial tem testemunhado, nas últimas décadas, um desenvolvimento tecnológico e científico que ocorre em velocidade e intensidade superiores ao verificado ao longo de toda a trajetória da humanidade. Este fenômeno produz, como não podia deixa de ser, profundas alterações nas relações humanas. As novas tecnologias têm modificado profundamente o perfil da sociedade, afetando relações, tensionando crenças e valores. Este desenvolvimento tem proposto uma reflexão sobre os limit...

  16. Fatores influentes na aderência ao tratamento em pacientes com risco cardiovascular

    OpenAIRE

    Rodríguez Acelas, Alba Luz; GÓMEZ OCHOA, ANA MARITZA

    2010-01-01

    Objetivo: descrever e analisar os fatores que influem na aderência ao tratamento farmacológico e não farmacológico em pacientes com risco de doença cardiovascular na Fundação Cardiovascular da Colômbia. Metodologia: estudo descritivo – metodológico realizado com 172 pacientes hospitalizados e de consulta ambulatória. O instrumento aplicado foi desenhado por Bonilla (8) e é útil para avaliar a aderência aos tratamentos farmacológicos e não farmacológicos em pacientes com fatores de risco de...

  17. Vírus ao serviço da indústria farmacêutica

    OpenAIRE

    Silveira, Bárbara de Magalhães

    2013-01-01

    Os vírus são parasitas intracelulares obrigatórios, conhecidos por infectarem e causarem doença em humanos. Com base na sua capacidade de se replicarem dentro de um organismo, os vírus têm vindo a ser estudados, com o intuito de causarem efeitos benéficos no tratamento de determinadas patologias, ou seja, como verdadeiras máquinas que se encontram ao dispor da indústria farmacêutica. Assim, ao longo deste texto, foi realizado um primeiro enquadramento teórico em que se pretende...

  18. Risk of loss power for ATWT in Daya Bay and Ling'ao nuclear power stations

    International Nuclear Information System (INIS)

    In order to analyze the differences between the Anticipated Transient Without Reactor Trip (ATWT) and other reactor protection methods, this paper analyzes in detail the realizing means of ATWT and the effect of lost of power supply on the units based on Daya Bay and Ling'ao Nuclear Power Stations by system wiring diagram. Based on the comprehensive analysis,this paper proposes the sequence for powering when recovering the power source after ATWT power supply (LCC/LNE) loss for Daya Bay and Ling'ao Nuclear Power Stations. (authors)

  19. Dicty_cDB: FC-AO17 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available FC (Link to library) FC-AO17 (Link to dictyBase) - - - Contig-U16254-1 FC-AO17Z (Link to Origina ... A sequence. 42 3.6 1 CB325093 |CB325093.1 UI-R-DZ0-crm -f-02-0-UI.s1 UI-R-DZ0 Rattus norvegicus cDNA clone ... UI-R-DZ0-crm -f-02-0-UI 3', mRNA sequence. 42 3.6 1 BX470146 |BX ...

  20. Instrumentos relacionados ao diabetes mellitus adaptados e validados para a cultura brasileira

    OpenAIRE

    Raquel Curcio; Maria Helena Melo Lima; Neusa Maria Costa Alexandre

    2011-01-01

    Trata-se de um estudo de revisão integrativa, cujo objetivo foi buscar evidências disponíveis na literatura sobre os instrumentos e escalas relacionados ao diabetes mellitus adaptados e validados para a cultura brasileira. Após busca nas bases eletrônicas BDENF, SciELO, LILACS, foram incluídos sete instrumentos que atenderam aos critérios de inclusão: Diabetes Mellitus Knowledge (DKN-A); Diabetes Mellitus Attitude (ATT-19); Diabetes Quality of Life Measure (DQOL-Brasil); Diabetes Quality of L...

  1. O panorama das Drogas no México: da margem da sociedade ao centro da cultura

    OpenAIRE

    Diana Palaversich

    2013-01-01

    O artigo destaca o percurso das manifestações culturais ligadas ao tráfico de drogas no México, de um lugar marginal, de subcultura, na sociedade mexicana das décadas de 1970 e 1980, expressas principalmente através dos narcocorridos e do narcocine, para um lugar no mainstream cultural mexicano, desde o início do século 21, com destaque especial para a narcoliteratura. O aumento da violência, provocado pela guerra ao narcotráfico, produz uma proliferação da temática nos meios de comunicação e...

  2. Aplicação de apoio ao agendamento cirúrgico

    OpenAIRE

    Mandzyuk, Ivanna

    2014-01-01

    Mestrado em Decisão Económica e Empresarial Um dos problemas que surge dentro do bloco operatório é o agendamento de cirurgias eletivas, ou seja, as cirurgias cuja realização tenha data previamente marcada. Na maioria dos hospitais portugueses, esta continua ainda a ser uma tarefa manual, difícil, e que exige muito tempo ao planeador cirúrgico. Este trabalho desenvolve uma ferramenta informática que permite apoiar o planeador cirúrgico, nas suas decisões, ao nível do agendamento dos cas...

  3. Quality control of Ling'ao nuclear power station civil construction

    International Nuclear Information System (INIS)

    Based on the quality control model adopted during Ling'ao Nuclear Power Station construction, the author briefly introduces quality control process of some main civil construction activities (reinforced concrete, steel liner, steel works and prestressing force) of nuclear power station, and makes some descriptions on non-conformance control of civil works. These quality control processes described come from the concrete practice during civil construction of Ling'ao Nuclear Power Station, and are based on Daya Bay Nuclear Power Station construction experience

  4. Estímulo ao desenvolvimento infantil: produção do conhecimento em enfermagem

    OpenAIRE

    Bruna Cristine Peres Falbo; Raquel Dully Andrade; Maria Cândida de Carvalho Furtado; Débora Falleiros de Mello

    2012-01-01

    Este estudo teve como objetivo identificar as ações de enfermagem para estímulo ao desenvolvimento infantil, em periódicos nacionais e internacionais, no período de 2000 a 2009. Revisão integrativa da literatura, nas bases de dados Medline e Lilacs, com análise de quinze artigos. Os resultados apontam o lúdico como essencial ao desenvolvimento infantil, devendo ser explorado pela enfermagem por meio da arte, música, brinquedos e teatro. Amenizar o estresse da hospitalização com adequação ambi...

  5. Imunidade celular em caninos neonatos - do nascimento ao 45° dia de idade

    Directory of Open Access Journals (Sweden)

    R.P. Klein

    2014-06-01

    Full Text Available O objetivo do presente trabalho foi acompanhar o desenvolvimento imunológico dos neonatos caninos, a fim de avaliar a imunidade celular pela análise dos leucócitos e linfócitos totais e das subpopulações de linfócitos T (CD4+ e CD8+ pela técnica de citometria de fluxo. Foram utilizados 30 cães neonatos de ambos os sexos, sem raça definida, aos três, 10, 17, 24, 31, 38 e 45 dias de idade. A contagem de leucócitos totais aos 45 dias (11.639±3.574 foi significativamente maior que no terceiro dia de idade (8.740±1.812 (P<0,05; não houve diferença entre a contagem total de linfócitos aos 45 dias em relação ao terceiro dia de idade. Quanto às subpopulações de LT CD4+ e LT CD8+, os percentuais de LT CD4+, aos três dias de idade (24,9±16,8%, foram inferiores quando comparados à média entre o 10°, o 24° e o 31°dia (35,5%, e os de CD8+, ao terceiro dia, menores em relação às médias do 10° e do 31° dia de idade. Pode-se concluir que as subpopulações de LT CD4+ e CD8+ sofrem oscilações durante o desenvolvimento pós-natal, sendo estas crescentes em relação aos níveis obtidos aos três dias de idade. A relação CD4+:CD8+ mostrou superioridade para o primeiro tipo celular, sendo que a maior relação entre CD4+ e CD8+ ocorreu no terceiro dia de idade. Com base nos resultados obtidos neste estudo, notaram-se as diferenças semanais nas populações linfocitárias, o que demonstra a dinâmica dessas células durante o período neonatal.

  6. [Study on Provenance of Kraak Porcelains from "Nan'ao I" Shipwreck].

    Science.gov (United States)

    Du, Jing-nan; Chen, Yue; Li, Nai-sheng; Ming, Chao-fang; Zhu, Jian; Luo, Wu-gan

    2015-06-01

    The "Kraak Porcelain" was a kind of Blue and White Porcelain which exported from China to Europe in Ming and Qing period. The study of Kraak Porcelain is a focus issue in international field of porcelain research. In 2007, the discovery of "Nan'ao I" Shipwreck of Ming Dynasty and the porcelains loaded in it, provided precious materials for the research on Kraak Porcelain. In this paper, we explored the provenance of 10 Kraak Porcelain samples from Nan'ao I, using both traditional visual method and WDXRF. PMID:26601402

  7. Zumbido no trabalhador exposto ao ruído Tinnitus in noise-exposed workers

    OpenAIRE

    Sandra Regina Weber; Eduardo Périco

    2011-01-01

    OBJETIVO: Verificar as características, prevalência e repercussão do zumbido em trabalhadores expostos ao ruído. MÉTODOS: Um total de 585 trabalhadores de uma indústria alimentícia foi questionado sobre zumbido. Aqueles que referiram zumbido por mais de cinco minutos e há mais de seis meses responderam à entrevista abordando histórico ocupacional e do zumbido, responderam ao questionário Tinnitus Handicap Inventory, e realizaram audiometria tonal. Foi realizada análise estatística dos dados. ...

  8. Desinfeção aplicada aos cones de guta-percha

    OpenAIRE

    Flor, Eduardo Rafael de Lima

    2015-01-01

    Introdução: Ao longo do tempo o Tratamento Endodôntico Não Cirúrgico tem sido das áreas da Medicina Dentária que mais tem evoluído. Todos os passos do tratamento têm sido revistos de forma a aumentar a taxa de sucesso. O controlo microbiológico é crucial para que o tratamento seja um sucesso a curto, médio e longo prazo. A assepsia deve ser mantida em todas as fases deste tratamento para que este seja um sucesso. Objetivo: Ao longo do meu percurso académico pude concluir que...

  9. Comportamento ao corte e à torção de compósitos

    OpenAIRE

    Cardoso, Cláudio César Machado

    2011-01-01

    O conhecimento do comportamento ao corte da camada dos laminados compósitos é essencial para o projecto com estes materiais, cujas aplicações estruturais têm vindo a aumentar significativamente. A revisão do estado do conhecimento na caracterização do comportamento ao corte revela que, apesar do número considerável de ensaios normalizados existentes, nenhum é universalmente aceite, tendo todos eles limitações relevantes. Neste trabalho recorreu-se a ensaios de tracção de laminados [±45º]n e a...

  10. Resistência ao Consumo em um Circuito Urbano de Parkour

    Directory of Open Access Journals (Sweden)

    Tatiana Maria Bernardo da Silva

    2011-08-01

    Full Text Available A partir de uma pesquisa alinhada ao método etnográfico, o presente trabalho tem por objetivo investigar os valores e as práticas de resistência ao consumo adotadas pelos membros de um circuito urbano de parkour no Rio de Janeiro. Confiando em uma abordagem indutiva e interpretativa amparada por um estudo empírico de base qualitativa, foram exploradas quatro categorias de análise: (1 a resistência como valor essencial; (2 um percurso de doação; (3 o consumo aprisiona; e (4 mobilização social e resistência.

  11. Resistência ao Consumo em um Circuito Urbano de Parkour

    OpenAIRE

    Tatiana Maria Bernardo da Silva; Alessandra Mello da Costa; José Luis Felicio Carvalho

    2011-01-01

    A partir de uma pesquisa alinhada ao método etnográfico, o presente trabalho tem por objetivo investigar os valores e as práticas de resistência ao consumo adotadas pelos membros de um circuito urbano de parkour no Rio de Janeiro. Confiando em uma abordagem indutiva e interpretativa amparada por um estudo empírico de base qualitativa, foram exploradas quatro categorias de análise: (1) a resistência como valor essencial; (2) um percurso de doação; (3) o consumo aprisiona; e (4) mobilização soc...

  12. The repair of ground cover of Bolivia-Brazil gas pipeline near Paraguay River crossing, in a swamp soft soil region, using geo synthetics reinforced backfilling; Reparo da cobertura do gasoduto Bolivia-Brasil junto ao Rio Paraguai, em trecho com solo mole, utilizando aterro reforcado com geosinteticos

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Cesar Augusto; Jorge, Kemal Vieira; Bechuate Filho, Pedro [TBG - Transportadora Brasileira Gasoduto Bolivia Brasil S.A., Campo Grande, MS (Brazil). Gerencia Regional Centro Oeste (CRGO); Teixeira, Sidnei H.C. [Geohydrotech Engenharia S.C. Ltda., Braganca Paulista, SP (Brazil)

    2005-07-01

    TBG - Transportadora Gasoduto Bolivia-Brasil S.A, executes routine maintenance works at the Gas Pipeline Right of Way, seeking its integrity. In the wetlands of Pantanal, near the Paraguay river crossing, the organic-alluvial soil was submitted to the process of subsidence. This process, associated with the river water flow erosion, shrank the soil volume and diminished or extinguished the pipeline land cover. The pipeline was exposed to the environment, and submitted to tension stresses and the risk of low cycle fatigue during the floods. The cathodic protection system also had to be evaluated, specially in the drought. To mitigate the problem, the embankment technique was adopted using sandy soil, reinforced with polyester geo-webs and with woven polipropene geo-textiles. The solution also used geo-webs with soil-cement as protection elements against the degradation of the geo-textiles blankets. Some monitoring works are associated with those interventions: monitoring of cathodic protection; topographical verification of horizontal and vertical displacements of the pipeline; levels of land covering, and rainfalls and flood measurement. The base of the embankment was built with hydraulic transported soil, and at the end consistently supported the gas pipeline. (author)

  13. The Magellan Adaptive Secondary VisAO Camera: Diffraction- Limited Broadband Visible Imaging and 20mas Fiber Array IFS

    OpenAIRE

    Kopon, Derek; Close, Laird M; Males, Jared R.; Gasho, Victor; Follette, Katherine

    2010-01-01

    The Magellan Adaptive Secondary AO system, scheduled for first light in the fall of 2011, will be able to simultaneously perform diffraction limited AO science in both the mid-IR, using the BLINC/MIRAC4 10\\{mu}m camera, and in the visible using our novel VisAO camera. The VisAO camera will be able to operate as either an imager, using a CCD47 with 8.5 mas pixels, or as an IFS, using a custom fiber array at the focal plane with 20 mas elements in its highest resolution mode. In imaging mode, t...

  14. Podridão-mole em pós-colheita de batata (Solanum tuberosum incitada por Pseudomonas viridiflava Post hervest soft rot in potabo (Solanum tuberosum induced by Pseudomonas viridiflava

    Directory of Open Access Journals (Sweden)

    Dirceu Macagnan

    2007-09-01

    Full Text Available Isolou-se uma bactéria incitadora de podridão-mole em batata e procurou-se identificá-la em nível de espécie. Testes biológicos, bioquímicos e tintoriais permitiram posicionar o microrganismo em questão com pertencente à espécie Pseudomonas viridiflava. Procurou-se também investigar a suscetibilidade de diferentes órgãos de reserva de distintas espécies botânicas à espécie bacteriana. Este trabalho mostra e confirma que outras espécies que não as de Pectobacterium spp. são capazes de incitar podridões-moles em órgãos de reserva.A soft rot inducing bacterium was isolated from decaying potato tubers and attempts were made to identify it at species level. Biochemical, biological and staining procedures allowed to identify it as belonging to the species Pseudomonas viridiflava. Additionally, the potential pathogenicity and host range of the identified isolate was checked by artificial inoculation of storage organs of different plants. This paper showed and confirmed that phytobacteria other than Pectobacterium spp are able to induce soft rot and that this fact deserves further investigation as far as crop losses due to prokaryotes are concerned.

  15. Characteristics of SAO and AO in equatorial middle atmospheric temperature pattern

    International Nuclear Information System (INIS)

    Complete text of publication follows. More than 10 years (1998-2008) of data from a low latitude station, Gadanki, India (13.5deg N, 79.2deg E), has been utilized to measure middle atmospheric temperature pattern, using lidar and TIMED/SABER, which exhibits the presence of semi-annual oscillation (SAO) and annual oscillation (AO). AO component is stronger in mesospheric region (80-90 km) and SAO is dominant at stratospheric altitudes (30-50 km). Overall, AO possesses higher amplitude ∼ 6 K, and SAO shows relatively less amplitude ∼ 1-2 K. AO at 90 km, has its crest around summer solstice, and the same at 80 shows peak around winter solstice with a downward progression speed ∼ 1.67 km/month. SAO propagates downward with an average phase speed ∼ 7 km/month and its phase maximizes around equinox and solstice at 50 and 30 km, respectively. Observed SAO has also shown seasonal asymmetry in the peak.

  16. Improvement of phase diversity algorithm for non-common path calibration in extreme AO context

    Science.gov (United States)

    Robert, Clélia; Fusco, Thierry; Sauvage, Jean-François; Mugnier, Laurent

    2008-07-01

    Exoplanet direct imaging with a ground-based telescope needs a very high performance adaptive optics (AO) system, so-called eXtreme AO (XAO), a coronagraph device, and a smart imaging process. One limitation of AO system in operation remains the Non Common Path Aberrations (NCPA). To achieve the ultimate XAO performance, these aberrations have to be measured with a dedicated wavefront sensor placed in the imaging camera focal plane, and then pre-compensated using the AO closed loop process. In any events, the pre-compensation should minimize the aberrations at the coronagraph focal plane mask. An efficient way for the NCPA measurement is the phase diversity technique. A pixel-wise approach is well-suited to estimate NCPA on large pupils and subsequent projection on the deformable mirror with Cartesian geometry. However it calls for a careful regularization for optimal results. The weight of the regularization is written in close-form for un-supervised tuning. The accuracy of NCPA pre-compensation is below 8 nm for a wide range of conditions. Point-by-point phase estimation improves the accuracy of the Phase Diversity method. The algorithm is validated in simulation and experimentally. It will be implemented in SAXO, the XAO system of the second generation VLT instrument: SPHERE.

  17. Modelo An\\'alogo Ac\\'ustico ao Buraco Negro de Schwarzschild

    CERN Document Server

    Toniato, Júnior Diniz

    2011-01-01

    Um fluido em movimento pode agir sobre o som da mesma forma que os espa\\c{c}o-tempos curvos podem influenciar na trajet\\'oria da luz na relatividade geral. Com isso, pode-se descrever a propaga\\c{c}\\~ao dessas ondas sonoras atrav\\'es de uma m\\'etrica efetiva, sob a qual elas seguir\\~ao geod\\'esicas nulas. Esta disserta\\c{c}\\~ao faz uma revis\\~ao destes estudos concentrando-se em uma analogia ac\\'ustica para um buraco negro de Schwarzschild, demonstrando suas vantagens e limita\\c{c}\\~oes quando aplicada para o estudo da teoria de Hawking. A fluid in moviment can act on the sound the same way that curved space-time can influence on light trajectory in the general relativity. So, one can describe the propagation these sound waves through an effective metric, under wich they will follow null geodesics. This thesis makes a review of these studies focusing in an analogy to Schwarzschild black hole using an acoustic system, showing its advantages and limitations when applied in the study of Hawking's theory.

  18. Subsea (0-40 m) terraces and benches, windward off Curaçao, Netherlands Antilles

    NARCIS (Netherlands)

    Focke, J.W.

    1978-01-01

    At the windward (NE) side of Curaçao at least two well-developed submarine terraces occur. A first, rocky, terrace, 100 to 150 m wide at depths of 5 m inshore to 12-15 m at the drop off, is densely covered with Sargassum. A second, sandy, terrace, approximately 50 to 100 m wide at depths of 32 to 40

  19. Accident sequence precursor analysis of Daya Bay and Ling'ao nuclear power plants

    International Nuclear Information System (INIS)

    The accident sequence precursor analysis method was adopted to evaluate the events of Daya Bay and Ling'ao Nuclear Power Plants, and some risk significant events which are called the accident sequence precursor were identified. By the statistics, classification and trend analysis, some useful insight can be obtained to support the nuclear safety management for the nuclear power plant. (authors)

  20. Performance of a MEMS-based AO-OCT system using Fourier Reconstruction

    Energy Technology Data Exchange (ETDEWEB)

    Evans, J; Zawadzki, R; Jones, S; Olivier, S; Werner, J S

    2009-01-21

    Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-resolution (3.5 {micro}m isotropic), 3-D images of the retina. The AO-OCT system at UC Davis has demonstrated the utility of this technology for microscopic, volumetric, in vivo retinal imaging. The current system uses an AOptix bimorph deformable mirror (DM) for low-order, high-stroke correction and a 140-actuator Boston Micromachines DM for high-order correction. Developments to improve performance or functionality of the instrument are on-going. Based on previous work in system characterization we have focused on improved AO control. We present preliminary results and remaining challenges for a newly implemented Fourier transform reconstructor (FTR). The previously reported error budget analysis is also reviewed and updated, with consideration of how to improve both the amount of residual error and the robustness of the system. Careful characterization of the AO system will lead to improved performance and inform the design of future systems.

  1. O suicídio como questão: melancolia e passagem ao ato

    Directory of Open Access Journals (Sweden)

    Marcos Vinicius Brunhari

    2014-06-01

    Full Text Available O artigo toma a questão do suicídio na obra de Freud como um problema de pesquisa que interroga certos pontos de sua metapsicologia: a possibilidade de uma tendência à autodestruição, o papel do eu e, finalmente, a dimensão do objeto que estaria implicada. É em relação a este último, em particular a seu estatuto na articulação que Freud propõe entre suicídio e melancolia, que o trabalho de Lacan em torno do objeto a, associado à passagem ao ato e à melancolia no Seminário, livro 10 - A angústia (1962-1963/2005, figura, no artigo, como um acréscimo à investigação iniciada por Freud. Essa referência lacaniana permitirá destacar a presença fulgurante do objeto a no momento da passagem ao ato suicida, estabelecendo uma articulação com a identificação melancólica descrita por Freud em seu "Luto e melancolia" (1917 [1915]/1969. A essa identificação absoluta ao objeto em questão é correlata a ausência de um sujeito e a ruptura mais radical em relação ao Outro.

  2. Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1

    International Nuclear Information System (INIS)

    Teleost vitellogenins (VTGs) are large multidomain apolipoproteins, traditionally considered to be estrogen-responsive precursors of the major egg yolk proteins, expressed and synthesized mainly in hepatic tissue. The inducibility of VTGs has made them one of the most frequently used in vivo and in vitro biomarkers of exposure to estrogen-active substances. A significant level of zebrafish vtgAo1, a major estrogen responsive form, has been unexpectedly found in heart tissue in our present studies. Our studies on zebrafish cardiomyopathy, caused by adrenergic agonist treatment, suggest a similar protective function of the cardiac expressed vtgAo1. We hypothesize that its function is to unload surplus intracellular lipids in cardiomyocytes for 'reverse triglyceride transportation' similar to that found in lipid transport proteins in mammals. Our results also demonstrated that zebrafish vtgAo1 mRNA expression in heart can be suppressed by both α-adrenergic agonist, phenylephrine (PE) and β-adrenergic agonist, isoproterenol (ISO). Furthermore, the strong stimulation of zebrafish vtgAo1 expression in plasma induced by the β-adrenergic antagonist, MOXIsylyl, was detected by Enzyme-Linked ImmunoSorbent Assay (ELISA). Such stimulation cannot be suppressed by taMOXIfen, an antagonist to estrogen receptors. Thus, our present data indicate that the production of teleost VTG in vivo can be regulated not only by estrogenic agents, but by adrenergic signals as well.

  3. Doença periodontal materna como fator associado ao baixo peso ao nascer Maternal periodontal disease as a factor associated with low birth weight

    Directory of Open Access Journals (Sweden)

    Simone Seixas da Cruz

    2005-10-01

    Full Text Available OBJETIVO: Estudos recentes têm apresentado evidências de que a doença periodontal em gestantes pode ser um dos determinantes do baixo peso ao nascer. Realizou-se estudo para verificar a existência de associação entre doença periodontal materna e baixo peso ao nascer. MÉTODOS: Estudo do tipo caso-controle com 302 mulheres, sendo 102 mães de nascidos vivos de baixo peso (grupo caso e 200 mães de nascidos vivos com peso normal (grupo controle. A existência de associação entre doença periodontal e baixo peso ao nascer foi avaliada mediante modelo multivariado de regressão logística, considerando outros fatores de risco para o baixo peso. RESULTADOS: Ambos os grupos de mães eram comparáveis no que se refere a idade, altura, peso pré-gestacional, tabagismo, alcoolismo, doenças prévias, estado civil, situação socioeconômica, número de escovações e uso de fio dental, número de refeições diárias, e visitas ao dentista. A doença periodontal foi diagnosticada em 57,8% das mães do grupo caso e 39,0% do grupo controle. A análise de regressão logística indicou associação positiva entre doença periodontal e baixo peso ao nascer (ORbruto=2,15; IC 95%: 1,32-3,48, especialmente entre as mães com escolaridade menor ou igual a quatro anos (ORajustada=3,98; IC 95%: 1,58-10,10. CONCLUSÕES: A doença periodontal é um possível fator de risco para o baixo peso ao nascer.OBJECTIVE: Recent studies have presented evidence that periodontal disease in pregnant women may be a determining factor for low birth weight. The present investigation was carried out to verify whether or not there is an association between maternal periodontal disease and low birth weight. METHODS: This was a case-control study on 302 women, of whom 102 were the mothers of live newborns of low weight (case group and 200 were the mothers of live newborns of normal birth weight (control group. The existence of an association between periodontal disease and low

  4. The complexity of national identity Construction in Curaçao, Dutch Caribbean

    Directory of Open Access Journals (Sweden)

    Rose Mary Allen

    2010-10-01

    Full Text Available Curaçao, one of the five islands of the Dutch Caribbean federation called the Netherlands Antilles, currently stands at a crossroad of constitutional reform. In the context of these changes at the political level, it is logical that national identities are being redefined and repositioned. The developments in the fashioning of national identities in Curaçao deserve attention locally but also regionally. How do people in Curaçao construct national identities in daily life? How is a national collective constructed on the one hand, and how are differences with other collectivities constructed on the other hand? The historical context of constitutional changes that have occurred over the years is considered as well as an examination of the present discourse on constitutional reform. These identity issues are then placed within a wider Caribbean context.  Resumen: La complejidad de la construcción de la identidad nacional en Curaçao,en el Caribe holandés Curaçao, una de las cinco islas de la federación caribeña neerlandesa llamada Antillas Holandesas, se encuentra hoy en día en una encrucijada de reformas constitucionales. En el contexto de estos cambios a nivel político, es lógico que las identidades nacionales sean redefinidas y reposicionadas. Los desarrollos en la formulación de identidades nacionales en Curaçao merecen atención local, y también regional. ¿Cómo construye la gente en Curaçao identidades nacionales en la vida cotidiana? ¿Cómo, por un lado, se construye el colectivo nacional y, por otro, cómo se construyen las diferencias con otras colectividades? En este análisis se estudia el contexto histórico de los cambios constitucionales que han ocurrido en el curso del tiempo y se realiza igualmente una revisión del actual discurso sobre la reforma constitucional. Estos problemas de identidad son analizados entonces en un contexto caribeño más amplio.

  5. Determinantes psicofisiológicos da resposta ao stress : aspectos do desenvolvimento e adaptação ao cancro da mama

    OpenAIRE

    Eusébio, Susana Filipa Gonçalves, 1983-

    2013-01-01

    Tese de mestrado, Neurociências, Faculdade de Medicina, Universidade de Lisboa, 2013 A investigação tem sustentado que os estilos de vinculação, relativamente estáveis ao longo do desenvolvimento, parecem influenciar o modo como os indivíduos respondem a situações de stress na vida adulta. Os esquemas cognitivos de vinculação insegura, associados a emoções negativas, parecem frequentemente relacionar-se com a doença física ou mental, verificando-se nesse contexto mecanismos psicobiológicos...

  6. Resistência de Eleusine indica aos inibidores de ACCase Eleusine indica resistance to ACCase inhibitors

    Directory of Open Access Journals (Sweden)

    R.A. Vidal

    2006-01-01

    Full Text Available Dentre as causas da ineficácia no controle de plantas daninhas destaca-se a resistência delas aos herbicidas. Os objetivos deste trabalho foram avaliar a suspeita de resistência de Eleusine indica a inibidores de acetil-CoA carboxilase (ACCase e investigar a ocorrência de resistência cruzada entre os inibidores de ACCase. Biótipo de Eleusine indica originado do Mato Grosso com suspeita de resistência aos herbicidas inibidores de ACCase foi avaliado em casa de vegetação na sua suscetibilidade para diversos produtos do grupo dos ariloxifenoxipropionatos e cicloexanodionas. Estudos de resposta à dose confirmaram que o biótipo era 18 vezes mais insensível ao sethoxydim do que biótipo suscetível nunca aspergido com herbicidas. Também se constatou resistência cruzada ao fenoxaprop, cyhalofop, propaquizafop e butroxydim. Não se observou resistência cruzada aos produtos fluazifop, haloxyfop, quizalofop e clethodim.Among the causes for weed control inefficacy, the worst one is resistance to herbicides. The objectives of this work were to evaluate an Eleusine indica biotype suspected of resistance to ACCase inhibitors and to investigate the occurrence of cross- resistance to several ACCase inhibitors. One biotype of Eleusine indica originated from Mato Grosso with suspected resistance to ACCase inhibitors was evaluated in a greenhouse in relation to its susceptibility to several products of the ariloxyphenoxypropionate and cyclohexanedione groups. Studies on dose response confirmed that the suspected biotype was 18 times more insensitive to sethoxydim than the susceptible biotype that had never been treated with herbicides. Cross-resistance was confirmed for fenoxaprop, cyhalofop, propaquizafop and butroxydim. No cross-resistance was observed with fluazifop, haloxyfop, quizalofop, and clethodim.

  7. Altura materna e peso da criança ao nascer Maternal height and birth weight

    Directory of Open Access Journals (Sweden)

    Euclides Ayres de Castilho

    1976-09-01

    Full Text Available Numa população de 498 gestantes sadias matriculadas no Centro de Saúde Geraldo Paula Souza, foi estudada a relação entre a altura materna e o peso da criança ao nascer, segundo a técnica de análise de regressão múltipla, tipo "stepwise", utilizando-se o subprograma "regression", componente do sistema "Statistical Package for Social Sciences" - SPSS. Essa técnica permite isolar o efeito de cada fator ajustado para a presença dos efeitos de outros fatores. O peso da criança ao nascer mostrou-se associado à idade gestacional, peso médio da gestante no 3.° trimestre da gravidez e ao sexo do recém-nascido, a um nível de significância de 5%. Idade materna, peso médio da gestante no 2.° trimestre da gravidez, altura materna e ordem de nascimento do recém-nascido não se mostraram associados com o peso ao nascer, ao citado nível de significância.The relationship between maternal height and birth weight was studied using a multiple regression approach with a "stepwise" solution. In the final stage of that procedure no correlation was found between maternal height and birth weight given the regression on gestational age, maternal weight, sex and birth order of the fetus.

  8. Resposta ao calcário e ao fósforo de genótipos de trigo com diferentes tolerâncias ao alumínio

    OpenAIRE

    FREITAS JOSÉ GUILHERME DE; CANTARELLA HEITOR; CAMARGO CARLOS EDUARDO DE OLIVEIRA; FERREIRA FILHO ANTONIO WILSON PENTEADO; PETTINELLI JÚNIOR ARMANDO; RAMOS VALDIR JOSUÉ; FELICIO JOÃO CARLOS

    2000-01-01

    O objetivo do trabalho foi avaliar a resposta, à calagem e ao fósforo, de quatro genótipos de trigo com diferentes tolerâncias à acidez do solo. Os experimentos foram instalados de 1987 a 1995 em um cambissolo ácido e de baixa fertilidade, sem irrigação e após pousio ou soja. O delineamento foi de blocos, em parcela subsubdividida, com quatro repetições. A parcela constou de três doses de calcário (0, 6,5 e 13 t ha-1); a subparcela, de três doses de P (0, 30 e 90 kg ha-1 de P2O5), e as subsub...

  9. Restriçao energética e propilenoglicol na prevençao da cetose e na produtividade de vacas holandesas de alta produçao

    OpenAIRE

    Vinne, Roger Van Der; Andriguetto, Jose Luciano

    2012-01-01

    Neste trabalho foram avaliadas técnicas que visam a prevenção da cetose e a diminuição do balanço energético negativo em vacas leiteiras de alta produção, com o objetivo de melhorar o desempenho produtivo destes animais. Vacas da raça holandesa (33 animais) com média de produção acima de 30 kg de leite por dia foram distribuídas em quatro grupos. Foram feitos os seguintes tratamentos: o primeiro grupo era o controle; o segundo recebeu a suplementação de 500 g de propileno glicol ao dia por vi...

  10. Medo, ansiedade e controle relacionados ao tratamento odontológico

    Directory of Open Access Journals (Sweden)

    SINGH Kira Anayansi

    2000-01-01

    Full Text Available Nosso objetivo foi avaliar medo, ansiedade e controle relacionados ao tratamento odontológico. Os sujeitos foram 364 crianças da faixa etária de 7 a 13 anos. Três questionários com questões de múltipla escolha foram aplicados em grupos de 10 crianças. O primeiro questionário destinou-se à avaliação do medo ao tratamento odontológico e outras situações. Foi traduzido e adaptado do "Child's Fear Survey Schedule"9 e contém 15 itens. O segundo questionário contém 20 itens relacionados as situações potencialmente produtoras de ansiedade. Foi traduzido e adaptado do "State Trait Anxiety Inventory for Children"16. O terceiro questionário contém 40 itens sendo 20 relacionados ao controle percebido e 20 ao controle desejado e foi traduzido e adaptado do "Child Dental Control Assessment"19. Em relação ao medo e ansiedade, a média dos escores foi mais elevada para o sexo feminino do que para o sexo masculino (P < 0,05. Em relação a idade, as crianças da faixa de 11 a 13 anos revelaram-se em média mais temerosas que as de 7 a 9 anos. Quanto ao controle percebido as crianças mais novas percebem mais controle do que as mais velhas. Em geral os dados indicam que valores mais altos de medo relacionam-se com valores mais baixos de controle percebido. As crianças que tinham realizado tratamento odontológico com anestesia mostraram-se mais temerosas do que aquelas que não foram submetidas a anestesia, o que permite inferir que a etiologia de medo pode relacionar-se a esse procedimento que pode envolver a percepção de incontrolabilidade.

  11. Resistência ao cisalhamento de solos e taludes vegetados com capim vetiver

    Directory of Open Access Journals (Sweden)

    Michele Cristina Rufino Barbosa

    2013-02-01

    Full Text Available Taludes vegetados são mais resistentes contra movimentos de massa e erosão pela água. A vegetação contribui para a estabilidade do solo, principalmente pelo aumento da resistência ao cisalhamento por meio do reforço oferecido pelas raízes. As espécies vegetais que mais têm sido eficientes na estabilização de taludes instáveis são as gramíneas, pertencentes à família Poaceae. Um exemplar dessa família, capim vetiver (Chrysopogonzizanioides (L. Roberty, tem se revelado muito eficaz nessa estabilização. Com o objetivo de avaliar a melhoria dos parâmetros de resistência ao cisalhamento oferecida ao solo pelas raízes do capim vetiver com o tempo de plantio, realizaram-se experimentos de cisalhamento direto por meio de amostras indeformadas de solo sem vegetação e cultivadas com capim vetiver na idade de um, dois, três e quatro anos de plantio. Também foram realizados experimentos de cisalhamento direto em talude do mesmo solo sem vegetação e com cobertura desse capim. Os resultados do ensaio de cisalhamento direto das amostras de talude de solo foram avaliados por três métodos de equilíbrio limite para verificação de um fator de segurança médio nos taludes. A partir dos ensaios de cisalhamento direto, determinaram-se os parâmetros de resistência ao cisalhamento (intercepto de coesão e ângulo de atrito interno, verificando que o capim vetiver proporcionou incremento de coesão aparente ao solo, sendo esse destacado após três anos de plantio do capim. Esse capim promoveu melhoria nos parâmetros de resistência com consequente elevação do fator de segurança de taludes e aumento da resistência ao cisalhamento de solos, o que auxiliou na estabilização de taludes em planos superficiais de ruptura.

  12. Resistência de genótipos de caupi ao caruncho

    Directory of Open Access Journals (Sweden)

    BARRETO PAULO DIÓGENES

    2000-01-01

    Full Text Available A utilização de resistência genética ao ataque de Callosobruchus maculatus (Fabr. tem sido alvo de investigação científica, especialmente no que diz respeito à identificação de fontes de resistência. O presente trabalho objetivou incorporar, ao grupo de caracteres desejáveis para o cultivo de caupi (Vigna unguiculata (L. Walp., resistência genética ao caruncho (C. maculatus. Foram realizadas hibridações dos genótipos IT81D-1045 e IT81D-1064 (portadores de resistência ao inseto com CNCx 252-1E/FB, CNCx 187-22D-1 e BR 1-Poty (capazes de transferir resistência a viroses, tolerância à seca, formação de grãos com padrão comercial, elevado potencial de produção e adaptabilidade a diferentes condições ambientais. Populações segregantes obtidas destes cruzamentos foram conduzidas pelo método SPD (descendência de uma única vagem, e na geração F5 foram realizadas seleções individuais. As linhagens obtidas foram avaliadas em conjunto com materiais de origens diferentes, utilizando-se parâmetros associados à infestação da praga. Foi constatado que os genótipos avaliados apresentaram variabilidade quanto à preferência à postura, número de insetos emergidos e número de sementes danificadas; as linhas EVx 37-15E e EVx 37-2E foram as que sofreram menor dano causado pelo caruncho; as variáveis número de ovos, número de insetos emergidos e número de sementes danificadas mostraram-se positiva e significativamente correlacionadas entre si; o grupo das linhagens que descendem de genitores resistentes apresenta valores significativamente inferiores aos obtidos pelas demais, o que indica que a resistência ao inseto se transmite geneticamente.

  13. Tamanho de amostras para quantificação da podridão-mole da alface e da couve-chinesa Sample size for assessment of soft rot in lettuce and Chinese cabbage

    Directory of Open Access Journals (Sweden)

    Adriano Márcio Freire Silva

    2008-02-01

    Full Text Available Os cultivos de alface e couve-chinesa podem ter a produção reduzida devido à ocorrência da podridão-mole, causada por Pectobacterium carotovorum subsp. carotovorum. O objetivo deste estudo foi determinar os tamanhos ideais das amostras para quantificação da incidência dessa doença em levantamentos no campo. Foram realizadas amostragens da incidência da podridão-mole em oito áreas de plantio de alface e cinco de couve-chinesa, situadas nos principais municípios produtores do Estado de Pernambuco. Considerando os resultados obtidos e um erro aceitável de 20%, em futuros levantamentos da incidência da podridão-mole em alface recomenda-se a amostragem de 32 parcelas de 4,5 m²/ha e 20 plantas/parcela, enquanto em couve-chinesa a amostragem de 22 parcelas de 10,5 m²/ha e 20 plantas/parcela. Para ambas as culturas não houve correlação significativa (P=0,05 entre os níveis de incidência da doença e os tamanhos das amostras.Lettuce and Chinese cabbage may present yield reduction due to the occurrence of soft rot caused by Pectobacterium carotovorum subsp. carotovorum. This study aimed to determine the ideal sample size for assessing disease incidence in field surveys. Samples of soft rot incidence were conducted in eight lettuce growing areas and five Chinese cabbage growing areas, located in the main production cities around Pernambuco State. Considering 20% of acceptable error, the results pointed out that future surveys of the soft rot incidence on lettuce should analyze 32 plots with 4.5 m²/ha and 20 plants/plot, while for Chinese cabbage the sample should include 32 plots with 10.5 m²/ha and 20 plants/plot. No significant correlation (P=0.05 was found between disease incidence levels and sample sizes for both crops.

  14. Complete mole in a dichorionic twin pregnancy after intracytoplasmic sperm injection Mola hidatiforme completa em gravidez bicoriônica após injecção intracitoplasmática de espermatozoides

    Directory of Open Access Journals (Sweden)

    Tiago José Santos de Matos Ferraz

    2013-01-01

    Full Text Available A dichorionic twin pregnancy with complete hydatidiform mole and coexistent fetus is a rare and challenging situation, whose pathogenesis has not been yet fully understood. We present a case of a 39-year-old woman who underwent intracytoplasmic sperm injection with two embryos transfer. The 12-week gestation ultrasound examination revealed normal fetus and placenta with features of hydatidiform mole, leading to pregnancy termination. Autopsy and histological examinations diagnosed a complete mole coexisting with a normal fetus, and the genetic analysis showed a diploid fetus with biparental genome and molar tissue with paternal diploidy. This case highlighted that complete molar pregnancies may still occur even though pregnancy is achieved after intracytoplasmic sperm injection. A review of the literature was performed by collecting data from the few similar reported cases and by commenting on the pathogenesis of this rare condition.Uma gravidez bicoriônica com mola hidatiforme completa e feto normal é uma situação rara e desafiadora, cuja patogênese não foi ainda totalmente compreendida. Apresenta-se o caso de uma mulher de 39 anos submetida à injeção intracitoplasmática de espermatozoides com transferência de dois embriões. Na ecografia pré-natal realizada na 12ª semana de gestação, foi identificado um embrião morfologicamente normal e uma placenta com características molares. Esta situação resultou na terminação eletiva da gravidez. A autópsia e o estudo histológico permitiram o diagnóstico definitivo de uma mola hidatiforme completa coexistindo com feto normal. A análise genética mostrou feto diploide com genoma biparental e tecido molar com diploidia paterna. Este caso ressaltou que as gestações com mola hidatiforme completa poderão ainda ocorrer, mesmo que a gravidez seja realizada após uma injeção intracitoplasmática de espermatozoides. Foram realizadas uma revisão dos raros casos descritos na literatura

  15. Isolation and characterization of an agaro-oligosaccharide (AO-hydrolyzing bacterium from the gut microflora of Chinese individuals.

    Directory of Open Access Journals (Sweden)

    Miaomiao Li

    Full Text Available Agarose (AP from red algae has a long history as food ingredients in East Asia. Agaro-oligosaccharides (AO derived from AP have shown potential prebiotic effects. However, the human gut microbes responsible for the degradation of AO and AP have not yet been fully investigated. Here, we reported that AO and AP can be degraded and utilized at various rates by fecal microbiota obtained from different individuals. Bacteroides uniformis L8 isolated from human feces showed a pronounced ability to degrade AO and generate D-galactose as its final end product. PCR-DGGE analysis showed B. uniformis to be common in the fecal samples, but only B. uniformis L8 had the ability to degrade AO. A synergistic strain, here classified as Escherichia coli B2, was also identified because it could utilize the D-galactose as the growth substrate. The cross-feeding interaction between B. uniformis L8 and E. coli B2 led to exhaustion of the AO supply. Bifidobacterium infantis and Bifidobacterium adolescentis can utilize one of the intermediates of AO hydrolysis, agarotriose. Growth curves indicated that AO was the substrate that most favorably sustained the growth of B. uniformis L8. In contrast, κ-carrageenan oligosaccharides (KCO, guluronic acid oligosaccharides (GO, and mannuronic acid oligosaccharides (MO were found to be unusable to B. uniformis L8. Current results indicate that B. uniformis L8 is a special degrader of AO in the gut microbiota. Because B. uniformis can mitigate high-fat-diet-induced metabolic disorders, further study is required to determine the potential applications of AO.

  16. Contribuição preliminar aos tipos polínicos da Tribo Mutisieae (Compositae

    Directory of Open Access Journals (Sweden)

    Grace Irene Imbiríba Pastana

    1988-01-01

    Full Text Available O presente trabalho é um estudo palinilógico de quartoze espécies brasileiras da Tribo Mutisieae, pertencentes ao Herbário do Museu Nacional - RJ (R. São dadas as respectivas descrições polínicas com desenhos dos grãos em vistas equatorial e polar, da L.O. e detalhe da exina. Acompanham uma tabela referente ao tratamento estatístico e dois diagramas comparativos.The present paper is a palynological study of the fourteen species of the Tribe Mutisieae, belong to the Museum Nacional Herbary - RJ (R. Several aspects relating caracteristics of Mutisieae pollen are treated such as polar and equatorial diameter, L. O.: table of statistical treatment and comparative diagrams are displayed.

  17. Sindrome da Cutis Laxa Ligada ao X: Caso Clínico

    OpenAIRE

    Lobo, Ana Luísa; Teixeira, Sandra; Tomás, Edite; Azevedo, Afonso; Reis, Armando

    2014-01-01

    A Síndrome da Cutis Laxa Ligada ao X ou síndrome do "Corno Occipital" é uma doença genética rara, de transmissão recessiva ligada ao cromossoma X, associada a um defeito do metabolismo do cobre.Apresenta-se um caso clínico deste síndrome numa criança com hiperlaxidez articular, hérnias inguinais recidivantes, fragilidade cutânea e ainda malformação urológica associando uma obstrução pieloureteral à direita e volumosos divertículos vesicais. Salienta-se o facto da obstrução da junção pielouret...

  18. Como surgiu o dia mundial dos direitos do consumidor? – de Kennedy aos nossos dias

    OpenAIRE

    Freitas, Pedro

    2012-01-01

    É objetivo deste trabalho explicar como surgiu o Dia Mundial dos Direitos do Consumidor. Coloco como pergunta - Que razões terão levado o Presidente Kennedy a preocupar-se com os direitos dos consumidores? Lanço como hipóteses de trabalho: 1- o crescimento económico nas décadas de 50 e 60 do séc. XX nos países mais industrializados levou ao desenvolvimento da sociedade de consumo; 2 – face ao poder das grandes empresas e à criação de associações de defesa do consumidor à escala mundial os pod...

  19. Resistencia natural de oito especies de madeiras do Norte e Nordeste do Brasil aos xilofagos marinhos

    OpenAIRE

    Serpa, Fernando da Gama

    2013-01-01

    A presente pesquisa visou avaliar a resistência natural de oito espécies de madeiras do Norte e Nordeste do Brasil aos xilófagos marinhos, com a finalidade de conhecer madeiras resistentes e suscetíveis aos xilófagos; relacionar a resistência das madeiras com o seu teor de sílica e alcalóides; definir o grau de ataque dos xilófagos; estabelecer um método padrão para determinar a resistência de madeiras em estado natural e preserva das contra o ataque dos xilófagos e aplicar método de visualiz...

  20. SILENCIAMENTO: A HISTORIOGRAFIA SOBRE A EDUCAÇAO FEMININA NA COLÔNIA

    OpenAIRE

    Fernanda Costa Frazão; Christianni Cardoso Morais

    2012-01-01

    RESUMO:O objetivo de nosso trabalho é analisar a produção historiográfica acerca da história da educação feminina no Brasil referente ao período colonial. Tomamos como fontes de pesquisa os resumos e trabalhos completos publicados nas edições I a VI do Congresso Brasileiro de História da Educação (realizadas em 2000, 2002, 2004, 2006, 2008 e 2011) e do I ao VI Congresso de Pesquisa e Ensino em História da Educação em Minas Gerais (2001, 2003, 2005, 2007, 2009 e 2011). Ademais, os artigos de 2...

  1. A escola "Rocha" ao espelho : relação com a comunidade

    OpenAIRE

    Macieira, Maria da Graça Vareiro

    2012-01-01

    O relatório que agora se apresenta sustenta-se na pesquisa diversificada abaixo inserta – nos conceitos que foram as ferramentas de leitura da realidade e os pressupostos de interpretação dessa vivência – e do percecionado e apreendido, ao longo dos anos, em contexto da Comunidade Educativa – aplicação dos conceitos teóricos à interpretação da realidade –, nomeadamente na Escola Secundária Rocha Peixoto, aqui, ao espelho e numa lógica de relação escola-comunidade. Mobilizada a prática pedagóg...

  2. The CfAO's Astronomy Course in COSMOS: Curriculum Design, Rationale, and Application

    CERN Document Server

    Cooksey, Kathy L; Porter, Jason; Raschke, Lynne; Severson, Scott; Hinkley, Sasha

    2010-01-01

    From 2001 to 2007, COSMOS provided a teaching and outreach venue for the Center for Adaptive Optics Professional Development Program (CfAO PDP). COSMOS is a four-week residential mathematics and science summer program for high-school students organized by the University of California on four of its campuses. Two topical science courses comprised each COSMOS cluster. An astronomy course has always formed a basis for the CfAO PDP-affiliated cluster. The course included a variety of pedagogical techniques to address a diversity of learners and goals. We outline the astronomy course---lectures, activities, etc.---and provide the rationale for what was taught, how it was aught, and when it was taught.

  3. A censura aos filmes ibero-americanos na governação de Marcello Caetano

    OpenAIRE

    Morais, Ana Bela

    2014-01-01

    Através do estudo dos processos de censura ao filmes hispano-americanos em Portugal durante os anos de governação de Marcello Caetano (finais de 1968-1974), pretendo investigar os critérios da Comissão de Censura em relação ao modo como eram censurados esses filmes. O presente trabalho apoia-se no estudo dos arquivos do Secretariado Nacional da Informação e Turismo. A informação produzida pela Comissão de Exame e Classificação de Espectáculos, durante o Estado Novo, está concentrada neste esp...

  4. Prevenção ao crime e teoria social Crime prevention and social theory

    OpenAIRE

    João Trajano Sento-Sé

    2011-01-01

    O artigo estabelece um diálogo entre a criminologia positivista e algumas correntes contemporâneas da prevenção ao crime inspiradas em teorias sociológicas. Através desse exercício, busca-se evidenciar que algumas das formulações focadas no campo da prevenção já aparecem, em estado embrionário, na agenda teórica positivista. Do mesmo modo, torna-se possível explicitar que alguns postulados empíricos e práticos do positivismo são menos estranhos às teorias contemporâneas de prevenção ao crime ...

  5. Resistência ao fogo de alvenarias sem função estrutural

    OpenAIRE

    Oliveira, Filipa Sofia Nunes

    2014-01-01

    Um incêndio é algo difícil de prever, assim como a sua consequência nos elementos de construção. Dessa forma, ao longo das últimas décadas, os elementos de construção têm sido alvo de diversos estudos a fim de avaliar os seus comportamentos quando solicitados em situação de incêndio. O International Building Code (IBC) descreve um método de cálculo analítico para a determinação da resistência ao fogo dos elementos da construção de acordo com os procedimentos de teste estabelecidos na ASTM ...

  6. Crítica ao postulado positivista da psicologia: de Heidegger a Foucault

    OpenAIRE

    Rômulo Marques dos Santos Ballestê; Ricardo de Barros Cabral

    2012-01-01

    A objetivação do ser humano, que segue os ideais de precisão das ciências físico-matemáticas, bem como a sua identificação com o fato biológico, orienta o projeto de ciência da psicologia, desde o século XIX. Michel Foucault aponta esta questão como um paradoxo. A redução do ser humano a objeto dado se mostra contrária às considerações de Martin Heidegger ao tratar do problema do Ser. Portanto, partindo das observações desses dois autores, será realizada uma crítica ao modelo positivista de c...

  7. Study of power source transfer time criteria for Ling'Ao NPP phase II

    International Nuclear Information System (INIS)

    The solution for source transfer time beyond criteria problem in LingAo project II is introduced in the paper. System is modified and criteria are updated. Analysis and tests are performed to get proper parameter. International rules are used to evaluate the new criteria. The problem is solved finally, contributing stable power supply to unit pre-peration, start-up and operation. Experience also gathered for CPR1000 new projects. (author)

  8. Análise de fatores associados ao significado do trabalho

    Directory of Open Access Journals (Sweden)

    Sergio Hideo Kubo

    2012-12-01

    Full Text Available O trabalho tem sido visto não somente como forma de obter a renda, mas também como atividade que proporciona realização pessoal, status social e possibilidade de estabelecer e manter contatos interpessoais, entre outros. Nesta pesquisa, teve-se como objetivo investigar os fatores que influenciam e conferem sentido ao trabalho, como centralidade do trabalho, normas da sociedade e objetivos e resultados valorizados. Na centralidade do trabalho, procurou-se investigar o grau de importância do trabalho dentro do contexto das diversas áreas da vida das pessoas, como família, lazer, religião e vida comunitária. Em normas da sociedade, foram analisados os pontos mais significativos no tocante ao que a sociedade deveria proporcionar ao indivíduo, assim como o que o indivíduo deveria fazer em prol da sociedade. Nos objetivos e resultados valorizados, foi pesquisado o que as pessoas buscam com o trabalho. A partir da pesquisa na literatura, foi elaborado um modelo inicial que, não se mostrando satisfatório segundo critérios estatísticos, foi substituído por outro que apresentou significância estatística e boa aderência aos dados. O modelo escolhido foi o que melhor goodness-of-fit apresentou, quando se utilizou modelagem de equações estruturais pelo método partial least square. O estudo revelou que o significado do trabalho se reflete, na ordem, na centralidade do trabalho, nos objetivos e resultados valorizados e, por último, nas normas sociais.

  9. Do corpo histérico ao "corpus" teórico

    Directory of Open Access Journals (Sweden)

    Francisco Ramos de Farias

    1992-09-01

    Full Text Available Este estudo aborda a maneira pela qual Freud, de forma original, efetuou uma leitura no corpo-sintoma da histérica e construiu uma clínica inédita destinada ao tratamento das neuroses. Esta clínica, fundada na transferência, é suportada pelo edifício teórico que tem o inconsciente e a sexualidade como paradigmas.

  10. Acidente Vascular Cerebral Hemorrágico Associado ao Consumo de Cocaína

    OpenAIRE

    Conceição, MC; V. Gomes; Baptista, A

    1998-01-01

    Os autores apresentam o caso clínico de um homem de 37 anos, fumador de cocaína, que foi admitido no serviço por acidente vascular cerebral hemorrágico. Faz-se a discussão dos diagnósticos diferenciais e uma referência aos tipos, formas de administração, metabolismo, características clínicas e toxicidade da cocaína.

  11. Prevalencia de nascimentos pre-termo por peso ao nascer: revisao sistematica

    Directory of Open Access Journals (Sweden)

    Mariangela F Silveira

    2013-10-01

    Full Text Available OBJETIVO Estimar a prevalência de nascimentos pré-termo por faixas de peso ao nascer e obter uma equação para correção de estimativas. MÉTODOS Revisão sistemática da literatura nacional, de 1990 a 2012, para identificar estudos com coleta primária de informações sobre peso ao nascer e idade gestacional. Foram selecionados 12 que contribuíram com tabulações da prevalência de nascimentos pré-termo para faixas de 100 g de peso ao nascer. Os resultados desses estudos foram combinados pelo método de polinômios fracionais, sendo obtidas curvas separadas para meninos e meninas, comparadas com os resultados do Sistema de Informações sobre Nascidos Vivos para os anos 2000, 2005, 2010 e 2011. RESULTADOS As estimativas da prevalência de nascimentos pré-termo, obtidas a partir dos estudos primários, foram superiores às do Sistema de Informações sobre Nascidos Vivos para praticamente todas as faixas de peso ao nascer. A prevalência relatada pelo Sistema de Informações sobre Nascidos Vivos foi de 7,1% em 2010, cerca de 38% menor do que a estimativa de 11,7% obtida com a equação de correção. CONCLUSÕES Os dados do Sistema de Informações sobre Nascidos Vivos quanto à prevalência de nascimento pré-termo não refletem a verdadeira dimensão da prematuridade no Brasil. Assim sendo, para sua utilização, será necessária a aplicação do fator de correção, conforme proposto.

  12. Real-time control for the high order, wide field DRAGON AO test bench

    Science.gov (United States)

    Basden, Alastair; Bharmal, Nazim A.; Bitenc, Urban; Dipper, Nigel; Morris, Tim; Myers, Richard; Reeves, Andrew; Younger, Eddy

    2014-07-01

    DRAGON is a high order, wide field AO test-bench at Durham. A key feature of DRAGON is the ability to be operated at real-time rates, i.e. frame rates of up to 1kHz, with low latency to maintain AO performance. Here, we will present the real-time control architecture for DRAGON, which includes two deformable mirrors, eight wavefront sensors and thousands of Shack-Hartmann sub-apertures. A novel approach has been taken to allow access to the wavefront sensor pixel stream, reducing latency and peak computational load, and this technique can be implemented for other similar wavefront sensor cameras with no hardware costs. We report on experience with an ELT-suitable wavefront sensor camera. DRAGON will form the basis for investigations into hardware acceleration architectures for AO real-time control, and recent work on GPU and many-core systems (including the Xeon Phi) will be reported. Additionally, the modular structure of DRAGON, its remote control capabilities, distribution of AO telemetry data, and the software concepts and architecture will be reported. Techniques used in DRAGON for pixel processing, slope calculation and wavefront reconstruction will be presented. This will include methods to handle changes in CN2 profile and sodium layer profile, both of which can be modelled in DRAGON. DRAGON software simulation techniques linking hardware-in-the-loop computer models to the DRAGON real-time system and control software will also be discussed. This tool allows testing of the DRAGON system without requiring physical hardware and serves as a test-bed for ELT integration and verification techniques.

  13. Do valor intrínseco e de sua aplicabilidade ao meio ambiente

    Directory of Open Access Journals (Sweden)

    Tânia Ap. Kuhnen

    2004-01-01

    Full Text Available O tema deste estudo é a teoria do valor sagrado da vida e sua aplicabilidade às questões de ética prática, mais especificamente ao meio ambiente. O objetivo geral consiste em apontar os limites da concepção de Dworkin sobre a teoria do sagrado, quando aplicada ao meio ambiente, e a solução que Singer oferece para a atribuição de valor ao mesmo. Justifica-se esse trabalho em decorrência da importância de se discutir, a partir da análise dessas teorias filosóficas, questões vinculadas ao estabelecimento de um princípio ético que, além de englobar, no campo da ação moral, todos os seres sencientes, envolva também o meio ambiente como um todo. Além disso, o tema que aqui se desenvolve é uma contribuição do raciocínio filosófico-teórico para a discussão de problemas relevantes no campo da ética prática. Esse estudo ainda se justifica por abordar a questão da linha moral divisória entre os seres que são ou não incluídos na comunidade moral, o que representa outro problema que concerne à ética. As diferentes formas de classificação não foram capazes de incluir todos os seres vivos no âmbito da comunidade moral. Há sempre exclusões, as quais tendem a diminuir com o surgimento de teorias éticas inovadoras, dentre elas as que serão abordadas a seguir.

  14. Diversity and spatial heterogeneity of mangrove associated sponges of Curaçao and Aruba

    OpenAIRE

    Hunting, E.R.; Van, Soest; Geest, van der, A.H.M.; A. DE VOS; Debrot, A.O.

    2008-01-01

    Sponges are major epibionts of mangrove roots in the Caribbean. Mangrove sponge communities in the Caribbean mainly consist of species that are typical to this habitat and community compositions often differ from those found on coral reefs nearby. Heterogeneity in species distributions between locations and within locations between roots is often reported. This study quantifi es the diversity and abundance of mangrove associated sponges in the inner bays of Curaçao and Aruba and correlates va...

  15. Subordinate but proud: Curaçao's free blacks and mulattoes in the eighteenth century

    Directory of Open Access Journals (Sweden)

    Wim Klooster

    1994-07-01

    Full Text Available Focuses on the socio-economic position of free non-whites in 18th-c. Curaçao. The manumission rate was relatively high and consequently a large group of free non-whites was created. Blacks and mulattoes enjoyed religious freedom as well as considerable economic freedom. Their growing numbers and social and economic assertiveness alarmed the whites, who gradually admitted the most successful mulattoes in their circles.

  16. Avaliação da sensibilidade da goiabeira 'Pedro Sato' ao ozônio

    Directory of Open Access Journals (Sweden)

    Regina Maria de Moraes

    2011-09-01

    Full Text Available O objetivo deste trabalho foi avaliar a sensibilidade da goiabeira 'Pedro Sato' ao ozônio (O3, em comparação à cultivar Paluma, descrita como sensível. Oito plantas de cada cultivar foram submetidas separadamente a ar filtrado e a ar filtrado + O3, cinco horas por dia, durante quatro dias. Foram avaliadas fotossíntese (Asat, injúrias foliares visíveis e concentração de antocianinas e taninos. Plantas das duas cultivares também foram expostas, durante três meses, a condições ambientais em local contaminado por O3, tendo-se avaliado fotossíntese, injúrias foliares e crescimento. Plantas fumigadas com O3 apresentaram redução de Asat e da atividade fotoquímica, além de manifestação de injúrias foliares. 'Paluma' apresentou maior redução de Asat, injúrias foliares mais severas e redução de taninos. Quando exposta ao ambiente contaminado, 'Paluma' apresentou trocas gasosas mais altas, mas apresentou redução de Asat 30 dias antes que 'Pedro Sato'. O crescimento não foi afetado em 'Pedro Sato', cujas injúrias foliares tiveram menor incidência, severidade e precocidade do que em 'Paluma'. A menor taxa de crescimento de 'Paluma' indica maior sensibilidade ao O3. Apesar de responder com menor intensidade ao estresse induzido pelo O3, a cultivar Pedro Sato não pode ser considerada tolerante, pois apresenta danos fotoquímicos, injúrias foliares e alterações nos conteúdos de metabólitos secundários quando exposta a esse poluente.

  17. Systems PbMoO4-BiAO4 (A=V, P)

    International Nuclear Information System (INIS)

    Using methods of X-ray phase, differential thermal and visual-polythermal analysis phase equilibria in the systems PbMoO4-BiAO4, where A=V, P are studied. Their fusibility diagrams are plotted. It is shown that in the system lead molybdate-bismuth orthovanadate extended solid substitution solutions are formed. Bismuth orthovanadate forms with lead molybdate an eutectic mixture

  18. World-wide deployment of Robo-AO visible-light robotic laser adaptive optics systems

    Science.gov (United States)

    Baranec, Christoph; Riddle, Reed; Law, Nicholas Michael; Lu, Jessica R.; Tonry, John; Tully, R. Brent; Wright, Shelley; Kulkarni, Shrinivas; Severson, Scott; Choi, Philip; Ramaprakash, A.; Chun, Mark; Connelley, Mike; Tokunaga, Alan; Hall, Donald

    2015-08-01

    In the next few years, several modest-sized telescopes around the world will be upgraded with autonomous laser adaptive optics systems based on the Robo-AO prototype deployed at the Palomar Observatory 1.5-m telescope. The prototype commenced scientific operations in June 2012 and more than 19,000 observations have since been performed at the ~0.12" visible-light diffraction limit. We are planning to move the prototype system to the 2.1-m telescope at Kitt Peak for a 3-year deployment which will serve a consortium of users including Caltech, the University of Hawai`i, IUCAA, NCU and institutions in China. Additionally, 2 months per year will be made available to the US astronomical community.New Robo-AO systems are in various stages of development: a clone by IUCAA for the 2-m IGO telescope in India; a natural guide star variant, KAPAO, by Pomona College at the 1-m Table Mountain telescope in California; and second generation Robo-AO systems are planned for the 3-m IRTF and 2.2-m University of Hawai'i telescopes on Maunakea, Hawai`i. The latter will exploit Maunakea's excellent observing conditions to provide higher Strehl ratios, sharper imaging, ~0.07", and correction to lambda = 400 nm. An additional infrared integral-field spectrograph will be fed by the UH 2.2-m Robo-AO system to quickly classify transients, such as supernovae and asteroids, discovered by the ATLAS system in Hawai`i.

  19. A caminho de uma memorizaçao dos sinais dos impactos cruzados entre variaveis estrategicas

    OpenAIRE

    Smida, Ali

    2013-01-01

    Á expressao "tudo o mais constante" [do latim "ceteris paribus"), apreciada pelos economistas, os segidores de prospectiva opoem a expressao "tudo o mais esta mudando”. Razao pela qual tem sido desenvolvidas ferramentas, em particular os cenarios e as matrizes de impactos cruzados, que tem sido colocadas  a disposiçao  da estretegia. Os cenarios tem tido um grande sucesso neste campo, mas a matrizes de impactos cruzados tem tido problemas para serem adotadas pelos estretegistas da empresa. Um...

  20. Óleos essenciais e extratos vegetais no controle da podridão mole em alface crespa Essential oils and plant extracts on the control of soft rot of crispy lettuce

    OpenAIRE

    Cristiane L Silva; Souza, Elineide B; Kátia CS Felix; Alice MG Santos; Márcia V Silva; Rosa de LR Mariano

    2012-01-01

    Avaliou-se o efeito de óleos essenciais e extratos vegetais no controle da podridão mole em alface, bem como, a influência desses produtos nas características físico-químicas desta hortaliça. Nos testes in vitro, discos de papel de filtro foram embebidos em 11 óleos essenciais e 20 extratos vegetais nas concentrações 0,0; 0,25; 0,50; 0,75 e 1% e 0,0; 10, 40, 70 e 100%, respectivamente, e depositados sobre meio de cultura contendo Pectobacterium carotovorum subsp. carotovorum (Pcc A1). Os halo...

  1. Podridão-mole em pós-colheita de batata (Solanum tuberosum) incitada por Pseudomonas viridiflava Post hervest soft rot in potabo (Solanum tuberosum) induced by Pseudomonas viridiflava

    OpenAIRE

    Dirceu Macagnan; Reginaldo da Silva Romeiro; Davi Mesquita de Macedo; Daniel Augusto Schurt

    2007-01-01

    Isolou-se uma bactéria incitadora de podridão-mole em batata e procurou-se identificá-la em nível de espécie. Testes biológicos, bioquímicos e tintoriais permitiram posicionar o microrganismo em questão com pertencente à espécie Pseudomonas viridiflava. Procurou-se também investigar a suscetibilidade de diferentes órgãos de reserva de distintas espécies botânicas à espécie bacteriana. Este trabalho mostra e confirma que outras espécies que não as de Pectobacterium spp. são capazes de incitar ...

  2. Microwelding of various metallic materials under ultravacuum (AO 138-10)

    Science.gov (United States)

    Assie, Jean Pierre; Conde, Eric

    1991-01-01

    The first finding from the AO 138-10 is that cold welding never occurred, and that microwelds didn't even affect the reference (presumably microweld prone) pairs of metals consisting of gold, silver, and chromium. The scientific disappointment from these results must be tempered by the notion of a static AO 138-10 experiment, reflecting the passive character of the global Long Duration Exposure Facility (LDEF) flight. Thus far, it has been theorized that cold welding results from the peeling of the oxide layer, that is formed in an earth environment, by the space environment since such a layer no longer grows in space. In fact, such stripping of the oxide layer supposes relative motion of the contacting materials. In the absence of such motion, as in this experiment, oxidation will preserve its integrity and continue to prevent microwelding. More bewildering is that there was no microwelding of the reference pairs. Even though AO 138-10 failed scientific expectations, as did the LDEF structure with cold welding, the positive, functional aspect to keep in mind is the safe operation of single-shot (appendage releasing and/or latching) mechanisms, unhindered by microwelding in a space vacuum, as now demonstrated by the statically representative pairs of materials. Other aspects of the experiment are discussed.

  3. Using the Fingerprinting Method to Customize RTLS Based on the AoA Ranging Technique

    Directory of Open Access Journals (Sweden)

    Bartosz Jachimczyk

    2016-06-01

    Full Text Available Real-time Locating Systems (RTLSs have the ability to precisely locate the position of things and people in real time. They are needed for security and emergency applications, but also for healthcare and home care appliances. The research aims for developing an analytical method to customize RTLSs, in order to improve localization performance in terms of precision. The proposed method is based on Angle of Arrival (AoA, a ranging technique and fingerprinting method along with an analytically defined uncertainty of AoA, and a localization uncertainty map. The presented solution includes three main concerns: geometry of indoor space, RTLS arrangement, and a statistical approach to localization precision of a pair of location sensors using an AoA signal. An evaluation of the implementation of the customized RTLS validates the analytical model of the fingerprinting map. The results of simulations and physical experiments verify the proposed method. The research confirms that the analytically established fingerprint map is the valid representation of RTLS’ performance in terms of precision. Furthermore, the research demonstrates an impact of workspace geometry and workspace layout onto the RTLS’ performance. Moreover, the studies show how the size and shape of a workspace and the placement of the calibration point affect the fingerprint map. Withal, the performance investigation defines the most effective arrangement of location sensors and its influence on localization precision.

  4. O enfermeiro frente ao desmame precoce na consulta de enfermagem à criança

    Directory of Open Access Journals (Sweden)

    Caroline Aparecida Coutinho Monteschio

    2015-10-01

    Full Text Available RESUMOObjetivo:analisar a atuação do enfermeiro frente ao desmame precoce em crianças menores de 6 meses de idade.Método:estudo descritivo de abordagem qualitativa. Participaram do estudo enfermeiros que realizavam consulta de enfermagem à criança de maneira programática em unidades de saúde da família em Cuiabá-MT. Os dados foram coletados nos meses de janeiro e fevereiro de 2012, por meio da observação participante da consulta de enfermagem. Para análise dos dados foi utilizada a análise de conteúdo.Resultados:os enfermeiros, na maioria das vezes, utilizaram estratégias apropriadas para o manejo dos problemas mais comuns na amamentação, apesar de algumas condutas não terem, ainda, evidência científica comprovada, quanto aos benefícios e/ou prejuízos à sua prática.Conclusão:os enfermeiros abordaram aspectos importantes do aleitamento materno durante as consultas e trabalharam em prol da promoção e do resgate ao aleitamento materno exclusivo.

  5. Simultaneous Nitrogen and Phosphorus Removal by Denitrifying Dephosphatation in a (AO)2 Sequencing Batch Reactor

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yan-ping; PENG Yong-zhen; WANG Shu-ying; WANG Shao-po

    2005-01-01

    A 24 L working volume reactor was used for the research on simultaneous phosphorus (P) and nitrogen (N) removal by denitrifying dephosphatation in an anaerobic-oxid-anoxic-oxid sequencing batch reactor ((AO)2SBR) system. The durations of each phase are: anaerobic 1.5 h, aerobic 2.5 h, anoxic 1.5 h, post-aerobic 0.5 h, settling 1.0 h, fill 0.5 h. The successful removal of nitrogen and phosphorus is achieved in a stable (AO)2SBR. The effluent P concentrations is below 1 mg/L, and the COD,TN and P average removal efficiency is 88.9%, 77.5% and 88.7%, respectively. The batch experiment results show that the durations of aerobic and anoxic phase influence the P removal efficiency. Some feature points are found on the DO, ORP and pH curves to demonstrate the complete of phosphate release and phosphate uptake. These feature points can be used for the control of (AO)2 SBR.

  6. Currículo universitário: do México ao Brasil neoliberais

    Directory of Open Access Journals (Sweden)

    Dostoiewski Mariatt de Oliveira Champangnatte

    2016-03-01

    Full Text Available Resumo O objetivo deste estudo foi discutir e comparar percepções e ações curriculares de professores universitários mexicanos e brasileiros. Contextualizando as realidades socioeconômicas dos dois países e, principalmente, as políticas governamentais voltadas ao ensino superior, observa-se, nas várias falas dos professores, uma abordagem simplista de currículo, significando-o apenas como preocupações de conteúdos administrados em disciplinas e planos de ensino. Aspectos da realidade social, política e econômica são desatrelados do pensamento e prática curriculares, onde o maior objetivo se tornou a adequação ao mercado de trabalho. Nota-se, direta e indiretamente, influências do pensamento e práticas neoliberais no posicionamento desses professores tanto quanto ao currículo como com a própria funcionalidade do ensino superior, refletindo e reproduzindo, em seus discursos e práticas, as políticas governamentais neoliberais vigentes.

  7. Profilaxia das úlceras associadas ao estresse Prophylaxis of ulcers associated with stress

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Pompilio

    2010-06-01

    Full Text Available INTRODUÇÃO: As úlceras da mucosa gastroduodenal que aparecem após graves insultos têm sido chamadas de úlceras associadas ao estresse ou, mais genericamente, de "doença mucosa associada ao estresse" (DMAE. São conhecidas desde a Antiguidade e apesar de relacionarem-se com altos índices de morbidade e mortalidade, esquemas de profilaxia no intuito de minimizar seus riscos, só foram introduzidos recentemente. Os inibidores da bomba de prótons têm desempenhado papel importante nesse cenário. MÉTODOS: O presente artigo é uma breve revisão sobre seu uso dentro do contexto clínico da profilaxia do sangramento gastrointestinal relacionado ao estresse.INTRODUCTION: Gastroduodenal mucosal ulcers that appear after severe insults have been called ulcers associated with stress or, more generally, "mucosal disease associated with stress" (DMAE. Are known since antiquity and although linked with high morbidity and mortality, prevention schemes in order to minimize their risk, were introduced only recently. The proton pump inhibitors have played an important role in this scenario. METHODS: This article is a brief review of its use within the clinical context of prophylaxis of gastrointestinal bleeding due to stress.

  8. Riscos e doenças ocupacionais relacionados ao exercício da anestesiologia

    Directory of Open Access Journals (Sweden)

    Daniel Volquind

    2013-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O exercício da anestesiologia não é isento de riscos para o anestesiologista. Considerada um local de trabalho insalubre em razão dos riscos potenciais que oferece, a sala de operações (SO é o local no qual o anestesiologista passa a maior parte do tempo. Nesta revisão, propomos uma análise dos riscos ocupacionais aos quais estão expostos os anestesiologistas em sua prática diária. CONTEÚDO: Apresentamos a classificação dos riscos e suas relações com as doenças ocupacionais. CONCLUSÃO: O controle dos riscos ocupacionais, aos quais os anestesiologistas são expostos diariamente, se faz necessário para o desenvolvimento de um local de trabalho adequado e com riscos reduzidos para a boa prática da anestesiologia. Isso contribui para a diminuição do absenteísmo, a melhora da assistência prestada ao paciente e da qualidade de vida do anestesiologista.

  9. Escala de atitudes face ao lazer em adolescentes e jovens adultos

    Directory of Open Access Journals (Sweden)

    Teresa Freire

    2007-04-01

    Full Text Available Atualmente, o lazer e as atitudes face ao lazer têm sido alvo de interesse na investigação psicológica, concretamente no domínio da Psicologia Social. O objetivo do presente estudo foi adaptar a escala Leisure Attitude Scale de Raghb e Beard, construída para avaliar as atitudes face ao lazer em função das três componentes de atitude (cognitiva, afetiva e comportamental para a população de estudantes, adolescentes e jovens adultos portugueses. Participaram no estudo 462 sujeitos (57,8% do sexo feminino e 42,2% do sexo masculino, com uma média de idades de 19,97 (desvio padrão de 4,85. Os resultados obtidos confirmam a estrutura e as características psicométricas da versão original, refletindo valores largamente aceitáveis de fidelidade (consistência interna e validade (validade de conteúdo quer para a escala total quer para as várias sub-escalas (cognitiva, afetiva e comportamental. Conclui-se pela adequação da escala na medida das atitudes face ao lazer, no contexto português.

  10. Transtorno afetivo bipolar: perfil farmacoterapêutico e adesão ao medicamento

    Directory of Open Access Journals (Sweden)

    Adriana Inocenti Miasso

    2012-06-01

    Full Text Available Este estudo teve como objetivos verificar a adesão de portadores de transtorno afetivo bipolar (TAB à terapêutica medicamentosa e identificar possíveis causas de adesão e não adesão ao medicamento de acordo com o perfil farmacoterapêutico. Trata-se de estudo transversal, descritivo, realizado em Núcleo de Saúde Mental de um município do interior paulista. Participaram do estudo 101 pacientes com TAB. Para coleta dos dados, utilizou-se a entrevista estruturada e o teste de Morisky-Green e, para a análise dos mesmos, o programa Statistical Package for the Social Science. Os resultados mostraram que a maioria (63% dos sujeitos investigados não adere ao medicamento. Apesar de não ter ocorrido diferenças significativas entre o grupo de aderentes e não aderentes, para as variáveis investigadas, foi possível verificar a utilização de polifarmacoterapia e regimes terapêuticos complexos no tratamento do TAB. Permanece como desafio a implementação de estratégias que possam melhorar, na prática, a adesão de pacientes ao tratamento medicamentoso.

  11. From Daya Bay to Ling Ao. The benefits of a duplication policy

    International Nuclear Information System (INIS)

    Over the past 15 years, the People's Republic of China has experienced very rapid economic growth of annual average 8%, which must be supported by fast expanding energy production, notably of electricity. China has the considerable amount of coal resources, but most of these resources are located in the north of the country, and the vast hydroelectric potential in Southwestern China is difficult to develop. Therefore, in the coastal provinces of Southeast China, where economic expansion is greatest, nuclear power has been chosen to meet the need. The Qinshan No. 1 PWR with 300 MWe output is the first Chinese nuclear power facility, and started the operation in 1992. Two 985 MWe PWRs have been operated since 1994 at Daya Bay. The construction of Qinshan No. 2 and 3 PWRs of 600 MWe each are in progress, and are expected to start the operation in 2001. These plants were designed by China based on the Framatome technology. Two more 985 MWe plants will be constructed on Ling Ao site, and operated in 2002 and 2003. The main milestones of Framatome collaboration with Chinese partners are explained. The Daya Bay nuclear power station and the Ling Ao project are reported. The benefits of duplicating the Daya Bay nuclear power station at Ling Ao are summarized. The M310 PWR plants of 985 MWe are the modern, proven type backed by more than reactor-years of operating experience. (K.I.)

  12. Would be the photon a composed particle? / Sobre a possibilidade da quantiza\\c{c}\\~ao dos fluxos de campo na radia\\c{c}\\~ao eletromagn\\'etica

    CERN Document Server

    Duarte, Celso de Araujo

    2013-01-01

    Here it is made a comparative analysis between the classical and the quantum expressions for the energy of electromagnetic radiation (ER). The comparison points to the possibility of the quantization of the magnetic and the electric field fluxes in the ER. ----- Apresenta-se uma an\\'alise comparativa entre as express\\~oes cl\\'assica e qu\\^antica para a energia da radia\\c{c}\\~ao eletromagn\\'etica (RE). A compara\\c{c}\\~ao nos aponta para a possibilidade de haver uma quantiza\\c{c}\\~ao dos fluxos dos campos magn\\'etico e el\\'etrico na RE.

  13. Participação em rede: do utilizador ao “consumidor 2.0” e ao “prosumer”

    OpenAIRE

    Amaral, Inês

    2012-01-01

    Os media sociais e os sites de rede social têm sido um elemento chave na acção colectiva através da Internet. E introduzem novas características ao conceito de “networking” online: interacção através da acção colectiva e interacção baseada nas práticas sociais promovidas pelas novas ferramentas técnicas. Os sites de partilha de conteúdo e as redes sociais são estruturados para uma sociabilidade centrada nos objectos sociais, que congregam conteúdo e actividade. Mas será que os media sociais a...

  14. Adaptive Optics at Optical Wavelengths: Test Observations of Kyoto 3DII Connected to Subaru Telescope AO188

    Science.gov (United States)

    Matsubayashi, K.; Sugai, H.; Shimono, A.; Akita, A.; Hattori, T.; Hayano, Y.; Minowa, Y.; Takeyama, N.

    2016-09-01

    Adaptive optics (AO) enables us to observe objects with high spatial resolution, which is important in most astrophysical observations. Most AO systems are operational at near-infrared wavelengths but not in the optical range, because optical observations require a much higher performance to obtain the same Strehl ratio as near-infrared observations. Therefore, to enable AO-assisted observations at optical wavelengths, we connected the Kyoto Tridimensional Spectrograph II (Kyoto 3DII), which can perform integral field spectroscopy, to the second generation AO system of the Subaru Telescope (AO188). We developed a new beam-splitter that reflects light below 594 nm for the wavefront sensors of AO188 and transmits above 644 nm for Kyoto 3DII. We also developed a Kyoto 3DII mount at the Nasmyth focus of the Subaru Telescope. In test observations, the spatial resolution of the combined AO188–Kyoto 3DII was higher than that in natural seeing conditions, even at 6500 Å. The full width at half maximum of an undersampled (1.5 spaxels) bright guide star (7.0 mag in the V-band) was 0.″12.

  15. Reação de cultivares de batata à podridão mole causada por Pectobacterium carotovorum subsp. atrosepticum, por P. carotovorum subsp. carotovorum e por P. chrysanthemi Reaction of potato cultivars to soft rot caused by Pectobacterium carotovorum subsp. atrosepticum, P. carotovorum subsp. carotovorum and P. chrysanthemi

    OpenAIRE

    Adilce I. H. Benelli; Norimar D. Denardin; CARLOS A. FORCELINI; Valmir Duarte

    2004-01-01

    A podridão mole em tubérculos de batata (Solanum tuberosum), causada por Pectobacterium carotovorum subsp. atrosepticum, por Pectobacterium carotovorum subsp. carotovorum e por P. chrysanthemi, é uma preocupante doença que causa danos expressivos à cultura em todo o mundo. Como inexiste tratamento eficiente para a podridão mole, o desenvolvimento de cultivares resistentes é considerado o método mais eficaz para a redução de perdas causadas pela doença. Nesse sentido, quatro cultivares de bata...

  16. Expressao genica associada ao estresse oxidativo no coracao de camundongo apos isquemia intestinal

    Directory of Open Access Journals (Sweden)

    Frederico Somaio Neto

    2014-03-01

    Full Text Available FUNDAMENTO: O fenômeno da isquemia e reperfusão intestinal é um evento frequente na clínica e está associado a repercussões deletérias em órgãos a distância, em especial ao coração. OBJETIVO: Investigar a expressão gênica do estresse oxidativo e defesa antioxidante no coração de camundongos isogênicos, submetidos a isquemia e reperfusão intestinal (IR. MÉTODOS: Doze camundongos (C57BL/6 foram distribuídos em dois grupos: Grupo IR (GIR com 60 min de oclusão da artéria mesentérica superior, seguidos de 60 min de reperfusão. Grupo Controle (GC submetidos a anestesia e a laparotomia sem o procedimento de IR observados por 120 min. As amostras de intestino e coração foram processadas pelo método (RT-qPCR / Reverse transcriptase - quantitative Polymerase Chain Reaction para determinar a expressão gênica de 84 genes relacionados ao estresse oxidativo ("t" de Student, p < 0,05. RESULTADOS: Observou-se no tecido intestinal (GIR uma expressão significantemente aumentada em 65 (74,71% genes em relação ao tecido normal (GC, e 37 (44,04% genes estiveram hiperexpressos (maior que três vezes o limiar permitido pelo algoritmo. No tocante aos efeitos da I/R intestinal a distância no tecido cardíaco verificou-se a expressão significantemente aumentada de 28 genes (33,33%, mas somente oito genes (9,52% se hiperexpressaram três vezes acima do limiar. Quatro (7,14% desses oito genes se expressaram simultaneamente nos tecidos intestinal e cardíaco. No GIR notaram-se cardiomiócitos com núcleos de menor tamanho, picnóticos, ricos em heterocromatina e raros nucléolos, indicando sofrimento cardíaco. CONCLUSÃO: A I/R intestinal promoveu a hiperexpressão estatisticamente significante de oito genes associados ao estresse oxidativo a distância no tecido miocárdico.

  17. A Tn5051-like mer-containing transposon identified in a heavy metal tolerant strain Achromobacter sp. AO22

    Directory of Open Access Journals (Sweden)

    Bhave Mrinal

    2009-03-01

    Full Text Available Abstract Background Achromobacter sp. AO22 (formerly Alcaligenes sp. AO22, a bacterial strain isolated from a lead-contaminated industrial site in Australia, was previously found to be resistant to moderate to high levels of mercury, copper and other heavy metals. However, the nature and location of the genetic basis for mercuric ion resistance in this strain, had not been previously identified. Findings Achromobacter sp. AO22 contains a functional mer operon with all four essential genes (merRTPA and shows >99% DNA sequence identity to that of Tn501. The mer operon was present on a transposon, designated TnAO22, captured by introducing a broad-host-range IncP plasmid into Achromobacter sp. AO22 and subsequently transferring it to E. coli recipients. The transposition frequency of TnAO22 was 10-2 to 10-3 per target plasmid transferred. Analysis of TnAO22 sequence revealed it belonged to the Tn21 subgroup of the Tn3 superfamily of transposons, with the transposition module having >99% identity with Tn5051 of a Pseudomonas putida strain isolated from a water sample in New York. Conclusion TnAO22 is thus a new variant of Tn5051 of the Tn3 superfamily and the transposon and its associated mercury resistance system are among the few such systems reported in a soil bacterium. Achromobacter sp. AO22 can thus be exploited for applications such as in situ mercury bioremediation of contaminated sites, or the mobile unit and mer operon could be mobilized to other bacteria for similar purposes.

  18. Adaptação e adaptação cruzada de Listeria monocytogenes aos compostos eugenol e carvacrol

    OpenAIRE

    E. R. N. SOUZA; V. M. R. TEBALDI; R.H. Piccoli

    2015-01-01

    RESUMOA evolução de certos microrganismos permite sua rápida adaptação aos ambientes em constante mudança, desenvolvendo assim, tolerância ou resistência ao aumento de determinados estresses. O uso de compostos bioativos provenientes da flora nativa tem sido apontado como uma possível solução para os problemas de controle da resistência e proliferação bacteriana. Este trabalho visou verificar a adaptação e adaptação cruzada de L. monocytogenes, frente aos compostos fenólicos eugenol e carvacr...

  19. Medicina moderna: rumo à prevenção, à cura, ao bem-estar e à longevidade

    OpenAIRE

    Ajai Singh

    2010-01-01

    A medicina moderna tem realizado muitas coisas nos campos de doenças infecciosas e de emergências para assistir a cura. Na maior parte dos outros campos, ela visa, sobretudo, ao controle, que é outro nome para o tratamento paliativo. A farmacologia, na qual se inclui a psicofarmacologia, é igualmente dirigida ao controle e ao alívio. Está na hora de profissionais da área e pesquisadores voltarem-se decisivamente para a prevenção e para a cura. Ademais, o outro grande desafio da medicina moder...

  20. Personalidade, resiliência e atitudes face ao envelhecimento em idosos do meio urbano e meio rural

    OpenAIRE

    Pinto, Ana Sofia Rodrigues

    2015-01-01

    Tese de mestrado, Psicologia (Secção de Psicologia Clínica e da Saúde, Núcleo de Psicologia Clínica Dinâmica), Universidade de Lisboa, Faculdade de Psicologia, 2015 A presente investigação refere-se ao estudo da personalidade, resiliência e atitudes face ao envelhecimento, numa amostra de indivíduos idosos. Os objetivos são: (1) analisar a influência do meio ecológico na resiliência e nas atitudes face ao envelhecimento; (2) analisar a relação da personalidade com a resiliência e ...

  1. A dimensão ética do cuidado de enfermagem ao idoso hospitalizado na perspectiva de enfermeiros

    OpenAIRE

    Aline Branco Amorim de Almeida; Maria Geralda Gomes Aguiar

    2011-01-01

    Estudo descritivo de abordagem qualitativa, realizado com oito enfermeiros de um hospital público, por meio de entrevistasemi-estruturada, objetivou compreender como estes percebem a dimensão ética do cuidado ao idoso. Os dados foram analisados conforme o método de análise de conteúdo e organizados nas categorias: Valores éticos no cuidado ao idoso e Problemas éticos no cuidado ao idoso. Revelou-se que os enfermeiros percebem a importância dos valores, principalmente o respeito e a responsabi...

  2. Cyberbullying – do diagnóstico de necesidades à construçao de um manual de formaçao.

    Directory of Open Access Journals (Sweden)

    Teressa Pessoa

    2011-01-01

    Full Text Available O impacto do cyberbullying na sociedade e junto das crianças e jovens, tão mais complexo quanto mais sofisticadas as ferramentas tecnológicas disponíveis, tem chamado a atenção para a importância, a nível internacional, da definição de estratégias de prevenção e intervenção junto de potenciais agentes educativos, isto é, para o desenvolvimento de uma proposta, com dimensão europeia, de Cyber- Training.Neste trabalho após uma breve apresentação do projectoCyberTraining: A Researchbased Training Manual On Cyberbullying1 dar-se-á a conhecer o processo de desenvolvimento de um manual de formação baseado numa investigação a nível europeu suportada na plataforma Moodle e, nesta, pela ferramenta Fórum. Através de uma análise de necesidades junto de formadores e do estudo, junto de especialistas, do estado de arte no domínio a nível de diferentes países, é mostrado todo um percurso inovador de construção colaborativa de conhecimento relativamente ao conceito cyberbullying assim como relativamente ao desenvolvimento de práticas de formação ou cybertraining.----------------------------------------------------------------The impact of the cyberbullying on society and among children and young people, revealed as ever more complex as more sophisticated technological tools becomeavailable, has called attention to the importance, at the international level, of a definition of strategies for prevention and intervention among potential educational agents, i.e. to develop a proposal for Cyber-Training, with a European dimension.In this paper, after a brief presentation of the European project CyberTraining: A Researchbased Training Manual on Cyberbullying, an account will be given of the process of developing a training manual based on research at European level supported in the Moodle platform, and within this, by the Forum tool. By means of a needs analysis among trainers and analysis by experts of the state of the art in

  3. Treatment of AO/OTA 31-A3 intertrochanteric femoral fractures with a percutaneous compression plate

    Directory of Open Access Journals (Sweden)

    Fei Luo

    2014-01-01

    Full Text Available OBJECTIVE: AO/OTA 31-A3 intertrochanteric femoral fractures have completely different fracture line directions and biomechanical characteristics compared with other types of intertrochanteric fractures. The choice of the fixation method has been a focus of dispute among orthopedic trauma surgeons. The purpose of this study was to review the outcomes of these fractures treated with a percutaneous compression plate at our institute. METHOD: Seventeen patients with AO/OTA 31-A3 intertrochanteric femoral fractures were treated with a percutaneous compression plate at our institute from January 2010 to December 2011. The clinical data and imaging results were retrospectively analyzed. RESULTS: The medical complication of popliteal vein thrombosis occurred in one patient. Sixteen patients were followed up for 12 to 21 months. Two patients had malunion and mild pain. Fracture collapse occurred in two patients, with one having head penetration. These two patients had moderate pain. There were no occurrences of nonunion or reoperation. The mean Harris hip score obtained during the last follow-up was 84.1 (61-97. Patients with a poor quality of reduction were more likely to have pain results (p = 0.001. A trend existed toward the presence of a poor quality of reduction (p = 0.05 in patients with a collapse of fracture. Patients with poor preoperative mobility were more likely to have a lower Harris hip score (p = 0.000. CONCLUSION: The percutaneous compression plate is an alternative device for the treatment of AO/OTA 31-A3 intertrochanteric femoral fractures. Good fracture reduction and an ideal placement position of the neck screw are important in the success of the device.

  4. LDEF (Prelaunch), AO135 : Effect of Space Exposure on Pyroelectric Infrared Detectors, Tray E05

    Science.gov (United States)

    1984-01-01

    LDEF (Prelaunch), AO135 : Effect of Space Exposure on Pyroelectric Infrared Detectors, Tray E05 The prelaunch photograph was taken in SAEF II at KSC prior to installation of the integrated tray on the LDEF. The Space Exposure on Pyroelectric Infrared Detectors Experiment (AO135) consist of twenty detectors of three different types of materials, lithium-tantalate, strontium-barium-niobate and triglycine-sulfide. The Pyroelectric infrered detector experiment is an integral part of the Active Optical System Component Experiment (S0050) that contains 136 test specimen and is located in a six (6) inch deep LDEF peripheral experiment tray. The experiment tray is divided into six sections, each consisting of a 1/4 inch thick chromic anodized aluminum base plate and a 1/16th inch thick aluminum hat shaped structure for mounting the test specimen. The test specimen are typi- cally placed in fiberglass-epoxy retainer strip assemblies prior to installation on the hat shaped mounting structure. Five of the six sections are covered by a 1/8 inch thick anodized aluminum sun screen with openings that allowed 56 percent transmission over the central region. Two subexperiments, The Optical Materials and UV Detectors Experiment (S0050-01) consist of 15 optical windows, filters and detectors and occupies one of the trays six sub-sections and The Optical Substrates and Coatings Experiment (S0050-02 ) that includes 12 substrates and coatings and a secondary experiment, The Holographic Data Storage Crystal Experiment (AO044) with four crystals, are also mounted in the integrated tray. The experiment structure was assembled with non-magnetic stainless steel fasteners.

  5. Adesão ao tratamento no transtorno bipolar Compliance to treatment in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Aida Santin

    2005-01-01

    Full Text Available O transtorno bipolar (TB é uma doença crônica, recorrente, presente em 1,5% da população, estando associada a altas taxas de mortalidade e prejuízos socioeconômicos. O lítio, a carbamazepina e o ácido valpróico são os estabilizadores de humor mais usados. Em tratamentos prolongados, como é o caso do TB, a má-adesão dos pacientes é uma das maiores dificuldades. Verifica-se que fatores ligados ao paciente, aos medicamentos e aos médicos possam ser responsáveis pela baixa adesão. A psicoeducação, a terapia cognitivo-comportamental e a terapia focada na família são estratégias propostas para o aumento da adesão.Bipolar disorder (BD is a chronic and recurrent illness that occurs in 1,5% of the population. This illness is associated with high rates of mortality and social/economic burden. Lithium, carbamazepine and valproic acid are the most used mood stabilizers. In long term treatments, as in BD, one of the main difficulties is the patient's adherence. It appears that factors associated to the patient, drug and the physician are responsible for the low adherence. The use of psycho-education, cognitive-behavioral therapy and focused family therapy have been put forward as a means to increase adherence.

  6. Avaliação da eficiencia do combate aos incendios florestais no Brasil

    OpenAIRE

    Lima, Gumercindo Souza

    2013-01-01

    Este trabalho teve como objetivo avaliar a eficiência do combate aos incêndios florestais no Brasil, com base em dados levantados no perlodo de 3.984 a 3.937. A eficiência do combate foi determinada baseada em três parimetros principais: a área queimada, avaliando a eFiciência em termos da dlstribuição dos incêndios ocorridos em diferentes classes de tamanho e observando a média da área queimada por Incêndio; o tempo para o ataque, em que se avaliou a mobilização dos combatentes, distribuindo...

  7. Diferenças entre adolescentes do sexo feminino e masculino na vulnerabilidade individual ao HIV

    OpenAIRE

    Renata Holanda Dutra dos Anjos; José Augusto de Souza Silva; Luciane Ferreira do Val; Laura Alarcon Rincon; Lucia Yasuko Izumi Nichiata

    2012-01-01

    O objetivo deste estudo foi analisar comparativamente a vulnerabilidade ao HIV/AIDS de homens e mulheres adolescentes, baseada em seus conhecimentos, valores e práticas. Trata-se de um estudo exploratório-descritivo com abordagem quantitativa. Os estudantes responderam a um questionário do qual foram selecionadas questões relevantes para análise. Totalizaram 207 adolescentes, sendo 43,5% do sexo masculino e 56,5% do feminino. A maior parte dos adolescentes declara já ter tido sua primeira rel...

  8. Atitudes face ao uso de Preservativo Masculino em contexto de Festa Académica

    OpenAIRE

    Frias, Ana; Sim-Sim, Margarida; Pontes, Ana; Palminhas, Edgar; Caldeira, Ermelinda; Casas Novas, Vitória

    2014-01-01

    Introdução: O percurso académico, além do ensino formal, possui momentos significativos pelo simbolismo de alguns eventos. A Receção aos Caloiros, representa a entrada num compartimento específico do saber e a Queima das Fitas, o atingir de competências para exercer uma Arte. Valorizadas por uns e menosprezadas por outros (Frias, 2003) a Praxe e as respetivas festividades levam a excessos, a alcoolização. Aumenta-se assim a probabilidade de sexo desprotegido e a exposição a Infeções Sexualmen...

  9. Fatores associados ao uso inconsistente do preservativo entre pessoas vivendo com HIV/Aids

    OpenAIRE

    Renata Karina Reis; Elizabete Santos Melo; Elucir Gir

    2016-01-01

    RESUMO Objetivo: analisar a prevalencia e fatores associados ao uso inconsistente do preservativo masculino entre pessoas vivendo com o HIV/Aids (PVHA). Método: estudo transversal realizado em serviços de atendimento especializados (SAE), com 228 PVHA. Realizou-se análise multivariada com modelo de regressão logística. Resultados: 143 participantes preencheram os critérios de inclusão e a prevalência do uso inconsistente do preservativo foi de 28,7%. Observou-se maior adesão entre os homen...

  10. Ilha das Flores, estatura e peso em crianças dos 6 aos 11 anos.

    OpenAIRE

    Antunes, Maria A. G.

    1990-01-01

    IV Expedição Científica do Departamento de Biologia – Flores 1989. 0s estudos de crescimento físico humano têm-se revelado de grande interesse pois permitem conhecer as características de diferentes populações e a variabilidade existente intra e interpopulações. Mas um dos aspectos mais importantes destes estudos talvez o de, ao se analisar o estado de crescimento e tempo de desenvolvimento do indivíduo, permitir destrinçar factores que influenciam nefastamente o crescimento. ...

  11. Patologia da tiróide associada ao consumo de amiodarona

    OpenAIRE

    Lopes, Zita Maria Teixeira Castro

    2013-01-01

    A amiodarona é um antiarrítmico rico em iodo, usado no tratamento de taquiarritmias, com efeitos adversos muitas vezes subvalorizados, entre os quais se destacam as alterações sobre a tiroide. Apesar de a maioria dos pacientes permanecer eutiroideia, a amiodarona interfere no metabolismo das hormonas da tiroide, por mecanismos intrínsecos ao próprio fármaco ou pelo seu alto conteúdo em iodo. Quando clinicamente evidente, esta disfunção da tiroide iatrogénica pode manifestar-se como hipotiroid...

  12. Contribuição ao estudo farmacognóstico da mutamba (Guazuma ulmifolia - Sterculiaceae)

    OpenAIRE

    Galina, Karen Janaina; Sakuragui, Cássia Mónica; Borguezam Rocha, Juliana Cristina; Lorenzetti, Emi Rainildes; Palazzo de Mello, João Carlos

    2005-01-01

    Guazuma ulmifolia Lam., Sterculiaceae, conhecida popularmente como mutamba, possui ampla distribuição geográfica, existindo desde o México até o sul do Brasil. O interesse pelas suas propriedades químicas deveu-se principalmente pela sua aplicação no tratamento capilar. Esta propriedade pode ser atribuída aos taninos, os quais apresentam atividade farmacológica, antiinflamatória, antiulcerogênica, antimicrobiana, ação de proteção capilar e prevenção na formação de radicais livres....

  13. Psicologia vocacional e feminismo crítico : do passado ao futuro

    OpenAIRE

    Saavedra, Luísa

    2013-01-01

    Durante algumas décadas a teoria e investigação vocacional caracterizaram-se por uma preocupação central com os homens brancos, de classe média e com as características individuais, guiada por pressupostos positivistas. Ao mesmo tempo, o aconselhamento focou-se fundamentalmente em mudanças de foro individual. Contudo, a intensificação da globalização, bem como o movimento pós-moderno, com as suas críticas à ciência, provocaram consideráveis mudanças nessas concetualizações. Ce...

  14. Os sentidos e significados atribuidos ao saber cultural no currículo

    OpenAIRE

    Iara Aquino Henn

    2010-01-01

    O presente artigo é fruto de uma pesquisa realizada na proposta pedagógica de Educação de Pessoas Jovens e Adultas de uma escola pública no Brasil. Investigamos os sentidos que os jovens e adultos atribuem aos conhecimentos construídos nas suas trajetória de vida e os significados que são produzidos na relação da sua cultura com os outros conhecimentos. A partir das reflexões de autores como Silva (2003), Padilha (2004), Hall (1997, 2003) Arroyo (2001), Fonseca (2002) indicamos três categoria...

  15. A FUNÇÃO SOCIAL DO DIREITO AUTORAL E O ACESSO AO CONHECIMENTO

    OpenAIRE

    Alexandre Azis Pereira Filho; Oseias Amaral; Naila Fernanda Sbsczk Pereira Meneguetti

    2014-01-01

    O presente estudo aborda o tema da função social do direito autoral e o acesso ao conhecimento em face do caráter individualista dos direito autorais.  Discute inicialmente o direito de propriedade a fim de apresentar o conceito de função social da propriedade. Analisa historicamente a evolução do direito de propriedade e o surgimento da ideia de função social. Busca enquadrar o direito autoral como um ramo do direito de propriedade, especificamente, a propriedade intelectual. Apresenta e dis...

  16. A CONTABILIDADE COMO BASE INFORMACIONAL AO DESENVOLVIMENTO DA ATIVIDADE AQÜICOLA: UM ESTUDO MULTICASO

    OpenAIRE

    Cristiano do Nascimento; Alessandra Vasconcelos Gallon

    2008-01-01

    Esta pesquisa, efetuada junto aos pequenos produtores catarinenses de moluscos cultivados no mar (mexilhão e ostra), objetivou investigar sobre a utilização dos dados e informações contábeis na condução de seus negócios. Para isto, realizouse um estudo exploratório-descritivo, com abordagem dos dados predominantemente qualitativa, por meio de um estudo multicaso. Os dados coletados em 29 unidades produtoras de moluscos, via questionário aplicado entre agosto e outubro de 2007, abordam aspecto...

  17. Localização de páginas web do conceito ao processo

    OpenAIRE

    Céu, Susana Maria Nogueira do

    2009-01-01

    Conceitos como Globalização, Internacionalização, Localização e Tradução surgem, na realidade da indústria da língua, com uma grande interligação, mas com perspectivas nem sempre concordantes. O nosso trabalho analisa, por isso, as diferentes definições propostas dedicando especial atenção ao conceito de localização, uma vez que o nosso projecto analisa o processo de localização de uma página Web desenvolvido num contexto empresarial real. O nosso enfoque recai mais específi...

  18. Recursos em areias e cascalhos ao largo da Ilha do Pico, Açores

    OpenAIRE

    Quartau, Rui; Teixeira, F. Curado; Monteiro, J. Hipólito; Bouriak, S.; Pinheiro, Luís M.; Cardigos, Frederico

    2003-01-01

    A campanha FAPI-2 realizada ao largo da ilha do Pico (Açores) permitiu a aquisição de perfis sísmicos de alta resolução (Chirp Sonar e Boomer) e de batimetria detalhada. Estes dados possibilitaram a definição das áreas mais promissoras em inertes (areias e cascalhos) na plataforma continental do Pico. Os resultados mostram que as áreas mais promissoras, são as que conjugam uma espessura elevada de sedimentos e um baixo declive de fundo.

  19. Pneumonia em organização secundária ao uso de amiodarona

    Directory of Open Access Journals (Sweden)

    GULMINI LIA AUGUSTA DE SOUZA

    2001-01-01

    Full Text Available A pneumonia em organização secundária ao uso de amiodarona é rara, com apenas oito casos relacionados na literatura. No presente relato uma paciente de 75 anos, com uso cumulativo de 43g, apresentou tosse produtiva, dispnéia progressiva e infiltrados bilaterais na radiografia do tórax. A biópsia transbrônquica confirmou o diagnóstico. Com a retirada da droga houve melhora clínica e funcional.

  20. Reconhecimento e validação da aprendizagem ao longo da vida

    OpenAIRE

    Serapicos, Maria do Amparo Lopes

    2008-01-01

    Este trabalho de investigação centra-se no estudo dos dispositivos de reconhecimento e validação de aprendizagens e competências adquiridas pelos adultos a margem do sistema formal de educação e formação. Esta problemática situa-se no contexto das mutações decorrentes da globalização, da emergência da sociedade do conhecimento e da aprendizagem ao longo da vida. O objectivo deste trabalho consiste em compreender como é que as aprendizagens que os adultos realizam a margem...

  1. Uso de suplementos para acasalamento de bezerras Angus aos 14 meses de idade

    OpenAIRE

    M.B. Alves; M.G. Rocha; L. Pötter; S.C.B. Stivanin; V.S. Hampel; Á.M. Fonseca Neto; M.J.O Sichonany; P.H. Moterle

    2016-01-01

    RESUMO O experimento foi conduzido com o objetivo de avaliar o desenvolvimento de novilhas de corte em três sistemas alimentares: exclusivamente em pastagem de azevém (Lolium multiflorum Lam.) ou em pastagem de azevém e recebendo 0,93% do peso corporal de grão de milho inteiro ou grão de aveia branca como suplemento. O delineamento experimental foi o inteiramente ao acaso, com medidas repetidas no tempo. A utilização da pastagem de azevém, com ou sem uso de grão de milho ou aveia como supleme...

  2. Eficiência de adubos fosfatados associados ao enxofre elementar na cultura do milho

    OpenAIRE

    Jucenei Fernando Frandoloso; Maria do Carmo Lana; Silvano Fontaniva; Rodrigo Vianei Czycza

    2010-01-01

    A eficiência agronômica dos adubos fosfatados pode ser afetada pelas fontes de fósforo, propriedades do solo, modo de aplicação e espécie vegetal. Com o objetivo de comparar a eficiência do fosfato natural reativo (FNR) e do superfosfato triplo (SFT) associado ao enxofre elementar, aplicados no sulco de plantio na cultura do milho, instalouse um experimento em condições de campo no município de Toledo, Paraná, em um Latossolo Vermelho eutroférrico. O delineamento experimental consistiu de blo...

  3. Do códige ao monitor: a trajetória do escrito

    Directory of Open Access Journals (Sweden)

    Roger Chartier

    1994-08-01

    Full Text Available Estariam os textos, de agora em diante, fadados a uma existência eletrônica? Os livros, na forma que conhecemos, desde o século XVI, estariam condenados a desaparecer progressiva e definitivamente? Antes de responder a essas perguntas, Roger Chartier percorre a longa história do livro até aos nossos dias: do volumen ao códice, da xilografia oriental à invenção de Gutenberg, da biblioteca de Alexandria até às nossas grandes bibliotecas modernas, do códice ao monitor. A nossa época encontra-se diante de um desafio: o de utilizar de modo adequado o suporte eletrônico do escrito, pois os significados de um texto dependem muito do suporte material deste. A felicidade extravagante vislumbrada diante da produção, consulta, comunicação imediata e universal de textos na telinha do computador deverá harmonizar-se com a consciência do papel reservado ao novo suporte: proteção, conservação e divulgação do patrimônio escrito da humanidade na sua materialidade tanto quanto na sua simbólica.Would texts, from now on, be fated to a mere electronic existence? Would books, in their format known since the sixteenth century, be condemned to disappear progressively and definitely? Before answering these questions we must follow the long history of books: from volumen to codex, from oriental xylography to Gutenberg's invention, from the Alexandrian bibliotheca to our great modern libraries, from codices to monitors. Our time faces a challenge: how to use appropriately the electronic support of writing, since the meanings of a text depend very much on its material support. The extravagant happiness gleamed before the production, the consultation, the immediate and universal communication of texts in the computer's screen should be in harmony with the conscience of the role reserved for the new support: protection, conservation and divulgation of the writing heritage of manking, both in its material and symbolic character.

  4. Percepção dos receptores sanguíneos quanto ao processo transfusional

    OpenAIRE

    Maritza Margareth Faquetti; Raquel Luzia Rosa; Maria Lígia dos Reis Bellaguarda; Daniele Delacanal Lazzari; Adriana Dutra Tholl; Cladis Loren Kiefer Moraes

    2014-01-01

    Pesquisa qualitativa, exploratória descritiva, que objetivou conhecer a percepção dos receptores sanguíneos quanto ao processo transfusional. A pesquisa foi realizada em uma unidade de hemoterapia de um município da região sul do Brasil e os dados foram analisados por meio do Discurso do Sujeito Coletivo. Foram entrevistados, por meio de instrumento semiestruturado, onze pacientes, homens e mulheres entre 30 e 95 anos, em recuperação pós-cirúrgica de cirurgia cardíaca, submetidos à transfusão...

  5. Atitude do consumidor em relação ao marketing (o caso português)

    OpenAIRE

    Correia, Luís Manuel Ferreira

    2012-01-01

    As estratégias de Marketing são cada vez mais estruturadas e direccionadas para públicos alvos, sendo consideradas imprescindíveis na comunicação entre empresas e consumidores. Grandes companhias absorvem orçamentos volumosos para conseguirem transmitir a mensagem ao consumidor final. Estratégias dinâmicas e reconhecidas de agências mundiais de Marketing, são contratadas por grandes companhias para dar a conhecer os seus bens e serviços, face a uma cada vez maior concorrência a...

  6. Novas abordagens terapêuticas no combate ao Envelhecimento Cutâneo

    OpenAIRE

    Santos, Joana Loureiro Marques dos

    2011-01-01

    Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas. O envelhecimento cutâneo é um processo complexo e multifatorial, que resulta em alterações funcionais e estéticas da pele. Os avanços na biologia da pele têm aumentado a compreensão da homeostasia deste órgão, assim como do seu processo de envelhecimento, levando ao desenvolvimento de tratamentos e técnicas com a finalidade de prevenir este mecanismo e de...

  7. Suscetibilidade do capim-colonião e de cultivares de milho ao flúor

    Directory of Open Access Journals (Sweden)

    Rimena Ramos Domingues

    2011-01-01

    Full Text Available A emissão de fluoretos à atmosfera oriunda da produção de superfosfatos e de cerâmica tem causado preocupação pelo efeito tóxico às plantas, contudo são poucos os estudos desenvolvidos acerca do problema com espécie de interesse econômico agrícola. Desenvolveu-se o estudo para avaliar o efeito do flúor (F atmosférico em plantas de capim-colonião e de cultivares de milho, utilizando como referência espécies bioindicadoras do tipo sensível e tolerante. As plantas foram expostas à contaminação pelo F atmosférico por curtos períodos durante 32 dias em sistema de nebulização com 0,16 mol L-1 de ácido fluorídrico no ambiente interno de uma câmara (~0,20 mmol m-3 de F, havendo um controle não exposto, com quatro repetições. A exposição das plantas ao F causou aumento da concentração do elemento nas folhas até 60 mg kg-1 para o capim-colonião, e entre 100 mg kg-1 nas folhas novas e 170 mg kg-1 nas folhas velhas para quatro cultivares de milho, o que demonstrou o efeito cumulativo do elemento no ambiente. Sintomas visuais da toxicidade foram observados nas plantas e se caracterizaram pela ocorrência de cloroses e necroses na lâmina foliar. O capim-colonião é uma espécie bastante sensível ao poluente no ar. As cultivares de milho DKB 390 e Ômega 8315 também são mais sensíveis ao F quando comparadas às AG7088 e 2B707. Os teores de clorofila a nas plantas foram mais afetados pelo F em relação aos teores de clorofila b.

  8. Delivery assistance in fetal macrosomia Assistência ao parto na macrossomia fetal

    Directory of Open Access Journals (Sweden)

    Renato Augusto Moreira de Sá

    2003-12-01

    Full Text Available OBJECTIVES: to evaluate delivery assistance in fetal macrosomia. METHODS: this was a hospital-based cohort study of consecutive births at a tertiary perinatal center from January 1, 1996 to October 31, 1999. A total of 5261 pregnancies met the inclusion criteria which were singleton pregnancies with minimal birth weight of 1000 g. Fetal macrosomia was defined as birth weight of 4000 g or more. We studied the mode of delivery, the newborn condition at birth, considered low when the Apgar scored below seven in the first or fifth minute, and the presence of abnormalities that could indicate a Caesarian section (disproportion, uterine dysfunction, prolonged second period of birth and fetal distress. RESULTS: 296 (5,6% of the babies were macrosomic. Macrosomia was a risk factor for Caesarian section (RR = 1,59, p OBJETIVOS: avaliar a assistência ao parto na macrossomia fetal. MÉTODOS: Estudo do tipo coorte realizado em centro perinatal terciário no período de 1 de janeiro de 1996 a 31 de outubro de 1999. Foram selecionadas 5261 gestações de acordo com os critérios de inclusão, que foram: gestação única e peso mínimo ao nascimento de 1000 g. A macrossomia fetal foi definida como peso ao nascimento acima de 4000 g. Estudamos a via de parto, as condições ao nascimento, Apgar baixo quando inferior a sete no primeiro e quinto minutos e as anormalidades que serviram de indicação para cesariana (desproporção, distocia uterina, segundo período prolongado e sofrimento fetal. RESULTADOS: 296 (5,6% dos conceptos eram macrossômicos. Macrossomia foi fator de risco para cesariana (RR = 1,59, p <0,001 e para parto operatório vaginal (RR = 1,12 p <0,001. As condições do recém-nascido não foram piores nos fetos macrossômicos. Houve correlação positiva entre macrossomia fetal e desproporção mas não para distocia uterina, prolongamento do segundo período ou sofrimento fetal. CONCLUSÕES: Houve maior número de indicações de cesariana

  9. Impacto no cuidador principal, do cuidado ao doente paliativo no domicílio

    OpenAIRE

    Neves, Sandra Cristina Silva

    2007-01-01

    O presente trabalho explora o .Impacto no cuidador principal, do cuidado ao doente oncológico paliativo no domicílio.. Trata-se de um estudo de carácter exploratório, descritivo, de abordagem qualitativa, no qual se utilizou como instrumento de colheita de dados um questionário sócio-demográfico e uma entrevista semiestruturada, que foram aplicados a dez cuidadores principais de doentes oncológicos paliativos acompanhados pela UAAD (Unidade Autónoma de Assistência Domiciliária). No tratamento...

  10. Translation between the Neer- and the AO/OTA-classification for proximal humeral fractures

    DEFF Research Database (Denmark)

    Brorson, Stig; Eckardt, Henrik; Audigé, Laurent;

    2013-01-01

    conduct prognostic studies, and to obtain consensus on treatment recommendations when concise definitions and a common 'fracture language' are lacking. Thus, we compared both classifications systems using primary data from large clinical studies to assess how thoroughly both systems conveyed clinically......The reporting and interpretation of data from clinical trials of proximal humeral fractures are hampered by the use of two partly incommensurable fracture classification systems: the Neer classification and the AO/OTA classification. It remains difficult to interpret and generalize results, to...

  11. Santo Daime: Teoecologia e adaptação aos tempos modernos

    OpenAIRE

    Maria Clara Rebel Araújo; Ricardo Vieiralves-Castro

    2009-01-01

    Este artigo resume os principais aspectos da pesquisa: “Santo Daime: Teoecologia e Adaptação aos tempos modernos”, dissertação de mestrado defendida em 2005 pelo PPG-PS/UERJ. O Santo Daime é uma religião que utiliza ritualmente um chá com propriedades psicoativas, acompanhado do canto de hinos que, segundo seus seguidores, tem poder de cura e ensinamentos.Como metodologia, foram realizadas  entrevistas semi-dirigidas, bem como uma análise do conteúdo dos hinos mais cantados, a fim de conhecer...

  12. Var??n de 30 a??os con dolor pretibial bilateral

    OpenAIRE

    Vargas-Hitos, Jos?? Antonio; Garc??a-Castro, Jos?? Miguel; Ja??n- ??guila, Fernando; Jim??nez-Alonso, Juan

    2012-01-01

    Var??n de 30 a??os que consultaba por dolor intenso y progresivo de dos meses de evoluci??n localizado en la cara anterior y distal de ambas piernas sin factor desencadenante aparente y mala respuesta a tratamiento analg??sico convencional. El paciente negaba otros s??ntomas a excepci??n de un rash eritematoso no pruriginoso generalizado que hab??a afectado tronco, palmas y plantas y que hab??a sido considerado como una reacci??n de hipersensibilidad a alguna de las medicaciones p...

  13. GeoGebra, algumas aplicações ao ensino da matemática

    OpenAIRE

    Fernandes, Carla Susana da Cruz

    2012-01-01

    Neste relatório de estágio pedagógico desenvolvemos material didático que auxilie o processo de ensino e aprendizagem da matemática no 3º ciclo do ensino básico e no ensino secundário. Para a sua realização utilizámos o programa de matemática dinâmica, GeoGebra. Este relatório encontra-se dividido em cinco capítulos. Encontramos, em anexo, actividades propostas pelo professor direccionadas ao aluno, algumas delas originais. Outras, retiradas de manuais escolares, foram melhoradas. Exist...

  14. Cuidados ao recém nascido em fototerapia: o conhecimento da equipe de enfermagem

    OpenAIRE

    Nathália Silva Gomes; Jesislei Bonolo do Amaral Teixeira; Elizabeth Barichello

    2010-01-01

    A icterícia é uma das alterações mais frequentes tanto em recém-nascidos a termo quanto em prematuros. A fototerapia é otratamento mais utilizado nestes casos, porém este tratamento pode ocasionar algumas alterações no bebê, as quais devem ser prevenidas e detectadas precocemente pela equipe de enfermagem. O objetivo do estudo foi identificar o conhecimento da equipe de enfermagem acerca dos cuidados ao recém-nascido e complicações relacionadas a fototerapia. Trata-se de um estudo prospectivo...

  15. Papel da oxidase alternativa na resistência ao stress oxidativo em Candida krusei

    OpenAIRE

    Barbosa, Matilde de Oliveira

    2008-01-01

    Tal como Candida albicans, C. krusei está associada a infecções fúngicas invasivas em indivíduos imunodeprimidos por SIDA ou por quimioterapia. Estas infecções fúngicas invasivas têm assumido particular relevância dado que na sua grande maioria se observam casos de resistência ao fluconazol e outros azois. Por outro lado, os mecanismos de patogenicidade de C. krusei não estão documentados sabendo-se que não se relacionam com os descritos para C. albicans. Na mitocôndria de todas as c...

  16. A crise económica e o acesso ao medicamento

    OpenAIRE

    Aveiro, João Miguel Almeida Moço

    2013-01-01

    O sector farmacêutico atravessa a par da restante economia uma grave crise, limitando o acesso das populações aos melhores cuidados de saúde. Hoje em dia é obrigatório que a indústria seja capaz de demonstrar o real benefício dos seus produtos, considerando tanto o nível terapêutico, como financeiro. Em Portugal existem uma série de factores que hoje em dia dificultam a possibilidade da indústria colocar à disposição das pessoas os melhores medicamentos. O Financiamento Públ...

  17. DO TEXTO AO DISCURSO: POTENCIALIZANDO O PROCESSO DE COMPREENSÃO DA LINGUAGEM

    OpenAIRE

    André Luiz Gaspari Madureira

    2013-01-01

    Neste artigo se propõe investigar as contribuições da análise discursiva para o processo de compreensão textual. Para tanto, antes é apresentado um posicionamento acerca da noção de texto, mediante os estudos bakhtinianos concernentes ao dialogismo. Depois é feita uma apreciação sobre o discurso, partindo-se da perspectiva da análise do discurso de linha francesa, fundamentada pelo filósofo Michel Pêcheux. A proposta de conjugação dessas posições linguístico-filosóficas se concentra na possib...

  18. Organizadores e cortadores de comprimidos: riscos e restrições ao uso

    OpenAIRE

    Caroline Ribeiro de Borja-Oliveira

    2013-01-01

    Com base em análise documental, foram discutidas e problematizadas as limitações associadas à utilização de organizadores e cortadores de comprimidos, como questão de saúde pública. Os organizadores destinados ao armazenamento e transporte de comprimidos e cápsulas expõem essas formas farmacêuticas a fatores ambientais dos quais estariam protegidos em suas embalagens originais, comprometendo sua estabilidade, eficácia e segurança. Os cortadores oferecem risco adicional quanto a perda da eficá...

  19. Mecanismos e fatores associados aos sintomas gastrointestinais em pacientes com diabetes melito

    OpenAIRE

    Mônica Loureiro Celino Rodrigues; Maria Eugênia Farias Almeida Motta

    2012-01-01

    OBJETIVOS: Apresentar a frequência, os principais fatores causadores dos sintomas gastrointestinais em pacientes portadores do diabetes melito e controvérsias quanto à sua ocorrência em crianças e adolescentes. FONTES DOS DADOS: Revisão não sistemática nas bases de dados MEDLINE/PubMed e SciELO (1983-2011), além de capítulos de livros relevantes. Foram selecionados os artigos mais atuais e representativos do tema. SÍNTESE DOS DADOS: A prevalência do diabetes melito vem aumentando ao longo dos...

  20. Entomologia - da idade média ao século XIX.

    OpenAIRE

    Tavares, João

    1983-01-01

    Remota à Idade Média os primeiros conhecimentos sobre os insectos, encontrando-se pintados e esculpidos nos vários monumentos do Egipto. LATREILLE (1819) cita entre outros a abelha, o sphex e o escaravelho rolador de bolas de excremento, sendo este último altamente venerado pelos egípcios, ao qual atribuíam uma multidão de virtudes reais ou simbólicas. No livro do êxodo encontramos que os Hebreus foram muitas vezes obrigados a alimentarem-se de gafanhotos, durante as suas peregrinações atravé...