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Sample records for anwendung adjuvanter strahlentherapie

  1. [Kombinierte Anwendung von Strahlentherapie und adjuvanter Therapie mit einem Mistelextrakt (Viscum album L.) zur Behandlung des oralen malignen Melanoms beim Hund: Eine retrospektive Studie].

    Science.gov (United States)

    von Bodungen, Uta; Ruess, Katja; Reif, Marcus; Biegel, Ulrike

    2017-01-01

    Hintergrund: Orale maligne Melanome (OMM) des Hundes zeichnen sich durch schnelles Wachstum, lokale Invasion und hohe Metastasierungsraten aus. Extrakte auf Basis von Viscum album L. (VAE) werden zunehmend in der Krebstherapie sowohl in der Human- als auch in der Veterinärmedizin eingesetzt. Ziel unserer Studie war es zu untersuchen, inwieweit die adjuvante Therapie mit VAE eine therapeutische Option zur Behandlung von OMM ist. Besonderes Augenmerk galt dabei der Überlebenszeit und möglichen Nebenwirkungen. Tiere und Methoden: 26 Hunde mit OMM, die in einem der größten veterinäronkologischen Zentren der Schweiz allesamt eine Strahlentherapie erhielten (teilweise nach operativer Tumorresektion) wurden in die retrospektive Studie eingeschlossen: 18 Hunde wurden mit VAE behandelt (1 ml VAE (Iscador®) in ansteigenden Konzentrationen von 0,1 bis 20 mg/ml subkutan 3-mal pro Woche (VAE-Gruppe), 8 erhielten keine adjuvante Behandlung (Vergleichsgruppe). Wir verglichen die Größenentwicklung der OMM sowie die Überlebenszeit. Ergebnisse: Patienten mit Bestrahlung und adjuvanter VAE-Therapie zeigten mit 236 Tagen eine signifikant längere mediane Überlebenszeit im Vergleich zu Patienten mit Bestrahlung, aber ohne adjuvante VAE-Therapie (49 Tage; Log-Rank-Test: p = 0,0047). Die VAE-Therapie verlängerte die Überlebenszeit um mehr als zwei Drittel (Hazard Ratio (HR) = 0,30, 95%-Konfidenzintervall (KI) 0,11-0,86; p = 0,024), während ein höheres Tumorstadium gemäß UICC (Union internationale contre le cancer) einen statistischen Trend zur Verdopplung des Sterberisikos zeigte (UICC-Stadium III/IV vs. I/II: HR = 2,12, 95%-KI 0,88-5,12; p = 0,095). Zwei Patienten zeigten milde Nebenwirkungen während der VAE-Behandlung. Einer der beiden zeigte 1 Tag lang ein selbstlimitiertes Fieber, bei dem anderen Patienten reduzierten wir die Dosis von einem konzentrierteren zu einem weniger konzentrierten VAE (Serie 0) aufgrund von Müdigkeit, die daraufhin verschwand

  2. Adjuvant chemo- and radiotherapy in gastrointestinal tumors; Adjuvante Chemo- und Strahlentherapie bei gastrointestinalen Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Sendler, A. [Technische Univ. Muenchen (Germany). Chirurgische Klinik und Poliklinik; Feldmann, H.J. [Technische Univ. Muenchen (Germany). Inst. und Poliklinik fuer Strahlentherapie und Radiologische Onkologie; Fink, U. [Technische Univ. Muenchen (Germany). Chirurgische Klinik und Poliklinik; Molls, M. [Technische Univ. Muenchen (Germany). Inst. und Poliklinik fuer Strahlentherapie und Radiologische Onkologie; Siewert, J.R. [Technische Univ. Muenchen (Germany). Chirurgische Klinik und Poliklinik

    1995-04-21

    In modern surgical oncology, adjuvant therapies are important complementary strategies. In local advanced carcinomas of the gastrointestinal tract, 5-year survival data are still disappointing despite standardized surgery. In this context, it has to be differentiated between adjuvant therapy following complete tumor exstirpation (so-called UICC R{sub 0} resection) and additive therapies following incomplete tumor resections (UICC R{sub 1} or R{sub 2} resection). Modalities in the adjuvant setting are chemotherapy, radiotherapy or the combined radio-/chemotherapy. In esophageal and gastric cancer there is up to now no benefit of postoperative adjuvant therapy. In pancreatic cancer, there are studies indicating a benefit of combined radio-/chemotherapy after complete tumor resection. A standard adjuvant chemotherapeutic treatment is proven in colon cancer stage III (Dukes C) with levamisole and 5-FU. Completely resected rectal carcinoma should be treated postoperatively with combined radio-/chemotherapy. In the common clinical or practical setting, adjuvant therapy is indicated only in locally advanced gastrointestinal tumors following R{sub 0} resection. Postoperative therapy following incomplete tumor resection has its reason only in a palliative intention. (orig.) [Deutsch] Adjuvante Therapiestrategien sind wichtige flankierende Massnahmen der modernen onkologischen Chirurgie, da u.a. die 5-Jahres-Ueberlebensquoten bei lokal fortgeschrittenen Tumoren des Gastrointestinaltraktes nach wie vor unbefriedingend sind. Dabei muss grundsaetzlich zwischen adjuvanten Behandlungen nach kompletter Tumorexstirpation (UICC-R{sub 0}-Resektion) und der additiven Therapie nach palliativer Resektion (UICC-R{sub 1}- oder -R{sub 2}-Resektion) unterschieden werden. Als Modalitaeten kommen Chemotherapie, Strahlentherapie und ihre Kombination in Frage. Bei Oesophagus- und Magenkarzinomen kann derzeit keine gueltige Empfehlung zur adjuvanten Therapie gegeben werden. Die Radio

  3. Assessment of potential adjuvanticity of Cry proteins.

    Science.gov (United States)

    Joshi, Saurabh S; Barnett, Brian; Doerrer, Nancy G; Glenn, Kevin; Herman, Rod A; Herouet-Guicheney, Corinne; Hunst, Penny; Kough, John; Ladics, Gregory S; McClain, Scott; Papineni, Sabitha; Poulsen, Lars K; Rascle, Jean-Baptiste; Tao, Ai-Lin; van Ree, Ronald; Ward, Jason; Bowman, Christal C

    2016-08-01

    Genetically modified (GM) crops have achieved success in the marketplace and their benefits extend beyond the overall increase in harvest yields to include lowered use of insecticides and decreased carbon dioxide emissions. The most widely grown GM crops contain gene/s for targeted insect protection, herbicide tolerance, or both. Plant expression of Bacillus thuringiensis (Bt) crystal (Cry) insecticidal proteins have been the primary way to impart insect resistance in GM crops. Although deemed safe by regulatory agencies globally, previous studies have been the basis for discussions around the potential immuno-adjuvant effects of Cry proteins. These studies had limitations in study design. The studies used animal models with extremely high doses of Cry proteins, which when given using the ig route were co-administered with an adjuvant. Although the presumption exists that Cry proteins may have immunostimulatory activity and therefore an adjuvanticity risk, the evidence shows that Cry proteins are expressed at very low levels in GM crops and are unlikely to function as adjuvants. This conclusion is based on critical review of the published literature on the effects of immunomodulation by Cry proteins, the history of safe use of Cry proteins in foods, safety of the Bt donor organisms, and pre-market weight-of-evidence-based safety assessments for GM crops. Copyright © 2016 Elsevier Inc. All rights reserved.

  4. Ultrasound motion tracking for radiation therapy; Ultraschallbewegungstracking fuer die Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Jenne, J. [Fraunhofer-Institut fuer Bildgestuetzte Medizin MEVIS, Bremen (Germany); Mediri GmbH, Heidelberg (Germany); Schwaab, J. [Mediri GmbH, Heidelberg (Germany)

    2015-11-15

    In modern radiotherapy the radiation dose can be applied with an accuracy in the range of 1-2 mm provided that the exact position of the target is known. If, however, the target (the tumor) is located in the lungs or the abdomen, respiration or peristalsis can cause substantial movement of the target. Various methods for intrafractional motion detection and compensation are currently under consideration or are already applied in clinical practice. Sonography is one promising option, which is now on the brink of clinical implementation. Ultrasound is particularly suited for this purpose due to the high soft tissue contrast, real-time capability, the absence of ionizing radiation and low acquisition costs. Ultrasound motion tracking is an image-based approach, i.e. the target volume or an adjacent structure is directly monitored and the motion is tracked automatically on the ultrasound image. Diverse algorithms are presently available that provide the real-time target coordinates from 2D as well as 3D images. Definition of a suitable sonographic window is not, however, trivial and a gold standard for positioning and mounting of the transducer has not yet been developed. Furthermore, processing of the coordinate information in the therapy unit and the dynamic adaptation of the radiation field are challenging tasks. It is not clear whether ultrasound motion tracking will become established in the clinical routine although all technical prerequisites can be considered as fulfilled, such that exciting progress in this field of research is still to be expected. (orig.) [German] In der modernen Strahlentherapie kann die Dosis mit einer Genauigkeit von 1-2 mm appliziert werden, sofern die Position der Zielstruktur genau bekannt ist. Liegt diese Zielstruktur (der Tumor) jedoch in der Lunge oder im Abdomen, koennen u. a. die Atmung oder die Peristaltik zu einer substanziellen Bewegung des Zielvolumens fuehren. Verschiedene Methoden zur intrafraktionellen Bewegungsdetektion

  5. Klare Regeln - effiziente und effektive FMEA-Anwendung

    OpenAIRE

    Schloske, Alexander

    2014-01-01

    Der Vortrag beschreibt klare Regeln zur effizienten und effektiven FMEA-Anwendung. - Denkmodelle für die verschiedenen FMEA-Arten (System-FMEA, Konstruktions-FMEA, Prozess-FMEA) - Anwendungsbereiche und FMEA-Planung - Strukturierung von FMEAs - Funktionen, Produktmerkmale und Prozessmerkmale - Risikoanalyse - Maßnahmendefinition - Risikobewertung - Präsentation von FMEAs - FMEA als "lebendes Dokument".

  6. Preclinical imaging in animal models of radiation therapy; Praeklinische Bildgebung im Tiermodell bei Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Nikolaou, K.; Cyran, C.C.; Reiser, M.F.; Clevert, D.-A. [Klinikum der Ludwig-Maximilians-Universitaet, Campus Grosshadern, Institut fuer Klinische Radiologie, Muenchen (Germany); Lauber, K. [Klinikum der Ludwig-Maximilians-Universitaet, Klinik und Poliklinik fuer Strahlentherapie, Muenchen (Germany)

    2012-03-15

    Modern radiotherapy benefits from precise and targeted diagnostic and pretherapeutic imaging. Standard imaging modalities, such as computed tomography (CT) offer high morphological detail but only limited functional information on tumors. Novel functional and molecular imaging modalities provide biological information about tumors in addition to detailed morphological information. Perfusion magnetic resonance imaging (MRI) CT or ultrasound-based perfusion imaging as well as hybrid modalities, such as positron emission tomography (PET) CT or MRI-PET have the potential to identify and precisely delineate viable and/or perfused tumor areas, enabling optimization of targeted radiotherapy. Functional information on tissue microcirculation and/or glucose metabolism allow a more precise definition and treatment of tumors while reducing the radiation dose and sparing the surrounding healthy tissue. In the development of new imaging methods for planning individualized radiotherapy, preclinical imaging and research plays a pivotal role, as the value of multimodality imaging can only be assessed, tested and adequately developed in a preclinical setting, i.e. in animal tumor models. New functional imaging modalities will play an increasing role for the surveillance of early treatment response during radiation therapy and in the assessment of the potential value of new combination therapies (e.g. combining anti-angiogenic drugs with radiotherapy). (orig.) [German] Die moderne Strahlentherapie profitiert massgeblich von einer detaillierten wie auch funktionellen praetherapeutischen Bildgebung. Die ueblicherweise praetherapeutisch eingesetzten radiologischen Standardverfahren wie die Computertomographie liefern zwar hochwertige morphologische Details, jedoch keine funktionelle Information. Es ist somit ein zunehmender Bedarf an funktionellen und molekularen Bildgebungsmodalitaeten feststellbar, mit denen ergaenzend zur morphologischen Bildgebung auch biologisch

  7. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

    Directory of Open Access Journals (Sweden)

    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  8. Radiation therapy in old patients. Side effects and results of radiation therapy in old patients; Strahlentherapie des alten Patienten. Vertraeglichkeit und Ergebnisse der Strahlentherapie aelterer Personen

    Energy Technology Data Exchange (ETDEWEB)

    Geinitz, H.; Zimmermann, F.B.; Molls, M. [Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Univ. Muenchen (Germany)

    1999-03-01

    leads to extensive atherosclerotic vessel damage should be kept in mind. Old patients should be monitored closely during therapy, since the loss of electrolytes or fluid is often not very well tolerated. Conclusion: The indication to radiation therapy of elderly cancer patients should take into account their performance status as well as the extent and the severity of comorbidity. Age per se is seldom a contraindication for radiation therapy. Regarding the available data in literature there is no indication for a dose reduction in radiation therapy only because of age, especially in the curative setting. (orig.) [Deutsch] Hintergrund: Die Anzahl alter Patienten in der Strahlentherapie steigt mit der zunehmenden Alterung der Bevoelkerung. Dennoch werden die damit verbundenen Fragen zur Vertraeglichkeit und Effektivitaet einer Strahlenbehandlung alter Menschen selten diskutiert. Material und Methode: Die Ergebnise einer Literaturrecherche zu epidemiologischen Daten, strahlenbiologischen Aspekten und Ergebnissen der Strahlentherapie alter Patienten werden dargestellt. Ergebnisse: Mit zunehmendem Alter nimmt die Krebsinzidenz zu. Sie liegt bei Maennern aelter als 85 Jahre bei ca. 3,5%. Bei einer durchschnittlichen Lebenserwartung von mehr als vier Jahren ist auch in dieser Altersgruppe der Einsatz einer kurativen Strahlentherapie sinnvoll. Ausserdem deuten verschiedene retrospektive Studien darauf hin, dass die Raten an lokaler Tumorkontrolle und krankheitsspezifischem Ueberleben nach Strahlentherapie mit denen juengerer Patienten vergleichbar sind. Eine Ausnahme bilden unter anderem aeltere Patienten mit Gliomen Grad III bis IV und mit Rektumkarzinom, die ein schlechteres Ueberleben aufweisen. Dieses ist eventuell auf eine weniger aggressive Kombinationstherapie (Tumorresektion) zurueckzufuehren. Obwohl strahlen- und molekularbiologische Daten auf einen Anstieg der Strahlenempfindlichkeit mit zunehmendem Alter hinweisen, wie zum Beispiel das Nachlassen der Kapazitaet

  9. Tratamento cirúrgico e terapias adjuvantes na papilomatose respiratória

    Directory of Open Access Journals (Sweden)

    Melissa Ameloti Gomes Avelino

    2013-10-01

    Full Text Available Papilomatose respiratória recorrente ou papilomatose laríngea recorrente é uma doença da laringe, causada pelo papiloma vírus humano, caracterizada por lesões epiteliais verrucosas e, geralmente, recorrentes. Na literatura são descritos diversos tipos de tratamento, como cirurgia a frio, a laser e/ou uso de microdebridador, além das terapias adjuvantes; todas no sentindo de diminuir possíveis sequelas permanentes da doença. OBJETIVO: Realizar uma revisão de literatura a respeito desta doença com ênfase nas técnicas cirúrgicas e terapias adjuvantes mais utilizadas atualmente. MÉTODO: Utilizou-se a metodologia de revisão bibliográfica, por meio de levantamentos em base de dados eletrônicos de domínio público, entre 1992-2012, utilizando-se as palavras-chave: papiloma, infecções por papillomavírus, laringe, terapêutica, vacinas contra papillomavírus. RESULTADOS: Foram levantados 357 artigos, dos quais 49 foram usados como base para esta revisão. Os trabalhos científicos apontam para a redução de recidiva na maioria das terapêuticas adjuvantes. Entretanto, o levantamento demonstrou metodologias e amostras diferentes, o que não permitiu comparar os tipos de tratamento e de terapias adjuvantes. CONCLUSÃO: A escolha da técnica cirúrgica varia entre os autores, porém, há uma tendência atual ao uso do microdebridador. As terapias adjuvantes recentes, como cidofovir, vacina tetravalente contra o papiloma vírus humano e bevacizumab, necessitam de estudos mais amplos.

  10. Radiotherapy for solitary plasmacytoma and multiple myeloma; Strahlentherapie bei solitaerem Plasmozytom und multiplem Myelom

    Energy Technology Data Exchange (ETDEWEB)

    Schmaus, M.C. [Universitaetsklinikum Heidelberg, Klinik fuer Radioonkologie und Strahlentherapie, Heidelberg (Germany); Neuhof, D. [MVZ Strahlentherapie und Nuklearmedizin Weinheim, Weinheim (Germany)

    2014-06-15

    Solitary plasmacytoma and multiple myeloma require a differentiated radiotherapy. The irradiation for plasmacytoma with an adequate total dose (medullary 40-50 Gy or extramedullary 50-60 Gy) leads to a high degree of local control with a low rate of side effects. In cases of multiple myeloma radiotherapy will achieve effective palliation, both in terms of recalcification as well as reduction of neurological symptoms and analgesia. In terms of analgesia the rule is the higher the single dose fraction the faster the reduction of pain. As part of a conditioning treatment prior to stem cell transplantation radiotherapy contributes to the establishment of a graft versus myeloma effect (GVM). (orig.) [German] Das solitaere Plasmozytom und das multiple Myelom fordern eine differenzierte Strahlenbehandlung. Bei Plasmozytomen fuehrt eine Bestrahlung mit ausreichender Gesamtdosis (medullaer 40-50 Gy oder extramedullaer 50-60 Gy) zu einer hohen Lokalkontrolle mit einer geringen Rate an Nebenwirkungen. Beim multiplen Myelom kann die Strahlentherapie eine effektive Palliation sowohl hinsichtlich Rekalzifikation als auch Reduktion neurologischer Symptomatik und Analgesie erzielen. Hinsichtlich der Analgesie gilt: Je hoeher die Einzeldosis, desto schneller der Wirkeintritt. Im Rahmen einer Konditionierungstherapie vor Stammzelltransplantation traegt die Strahlentherapie zur Etablierung eines Graft-versus-Myelom-Effekts (GvM) bei. (orig.)

  11. Radiotherapy and oncology. Medical technical radiology assistant, vocational training. 4. rev. ed; Strahlentherapie und Onkologie. MTA R Ausbildung

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, R. [Klinik und Poliklinik fuer Strahlentherapie, Univ. Erlangen-Nuernberg, Erlangen (Germany)

    2003-07-01

    The toolbook is arranged in seven main parts. 1. General Part, with the chapters: - History of radiology and radiation therapy - Radiation therapy, radiotherapy, radiation oncology - Organisational aspects of radiation oncology in the hospital department and private practice - The MTRA in radiation therapy. 2. General Oncology, with the chapters: Tumor pathology - Epidemiology and aethiology - Tumor prophylaxis (prevention) - Fundamentals of tumor treatment - Tumor treatment strategies - Fundamentals of surgical tumor treatment - Fundamentals of internal medicine treatment of tumors. 3. Foundations of Radiation Therapy, with the chapters: - Radiation physics - Dose concepts and dose units - Radiobiology - Foundations of radiopathology - Special pathology - Instrumentation. 4. Radiation Treatment, with the chapters: Irradiation planning - Daily radiation treatment - Psychological patient management - Emergency management. 5. Special Oncology of Tumors, with 16 chapters discussing tumors of specific organs, and 2 chapters dealing with palliative radiation therapy and supportive treatment. 6. Radiation Therapy of Benign Neoplasms, with the chapters: Survey - Antiphlogistic radiation treatment - Radiation treatment for alleviation of irritations and pains induced by chronic inflammatory or degenerative processes - Radiation treatment of hypertropic lesions of the connective and supporting tissue, and benign tumors - Irradiation for immunosuppression - Castration by irradiation. 7. Radiation Protection. (orig./CB) [German] Das vorliegende Buch gliedert sich in die folgenden 7 Teile: 1. Allgemeiner Teil mit den Kapiteln Geschichte der Radiologie und Strahlentherapie, Strahlentherapie - Radiotherapie - Radioonkologie, Organisation der Radioonkologie in Krankenhaus und freier Praxis, und die MTAR in der Strahlentherapie; 2. allgemeine Onkologie (Tumorpathologie, Epidemiologie und Aetiologie, Tumorprophylaxe (Praevention), Grundlagen der Tumordiagnostik, Strategien der

  12. Radiotherapy for treatment of induratio penis plastica; Strahlentherapie bei Induratio penis plastica

    Energy Technology Data Exchange (ETDEWEB)

    Bruns, F.; Kardels, B.; Schaefer, U.; Schoenekaes, K.; Willich, N. [Westfaelische Wilhelms-Univ., Muenster (Germany). Klinik und Poliklinik fuer Strahlentherapie-Radioonkologie

    1999-06-01

    Radiotherapy is shown to be an effective, low-cost and non-invasive modality for treatment of induratio penis plastica. Its efficiency could be proven especially for inflammatory stages of the disease, or as an alternative after failure of conventional treatment. A total dose of no more than 20-25 Gy was found to achieve clear improvements in two thirds of the patients treated, while avoiding at the same time cosmetically disadvantageous late effects. (orig./CB) [Deutsch] Die Strahlentherapie ist eine wirksame, kostenguenstige und nicht-invasive Behandlungsmoeglichkeit bei Induratio penis plastica. Ihren Stellenwert konnte sie insbesondere im inflammatorischen Stadium und nach Versagen anderer konservativer Therapieansaetze zeigen. Eine Gesamteinstrahldosis von 20-25 Gy reicht aus, um bei 2/3 der Patienten eine deutliche Besserung der Symptomatik zu erzielen bei gleichzeitiger Vermeidung kosmetisch relevanter Spaetnebenwirkungen. (orig.)

  13. Radiotherapy; Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Wannenmacher, M. [Heidelberg Univ., Mannheim (Germany). Abt. fuer Klinische Radiologie; Debus, J. [Univ. Heidelberg (Germany). Abt. Radioonkologie und Strahlentherapie; Wenz, F. (eds.) [Universitaetsklinikum Mannheim (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2006-07-01

    The book is focussed on the actual knowledge on the clinical radiotherapy and radio-oncology. Besides fundamental and general contributions specific organ systems are treated in detail. The book contains the following contributions: Basic principles, radiobiological fundamentals, physical background, radiation pathology, basics and technique of brachytherapy, methodology and technique of the stereotactic radiosurgery, whole-body irradiation, operative radiotherapy, hadron therapy, hpyerthermia, combined radio-chemo-therapy, biometric clinical studies, intensity modulated radiotherapy, side effects, oncological diagnostics; central nervous system and sense organs, head-neck carcinomas, breast cancer, thorax organs, esophagus carcinoma, stomach carcinoma, pancreas carcinoma, heptabiliary cancer and liver metastases, rectal carcinomas, kidney and urinary tract, prostate carcinoma, testicular carcinoma, female pelvis, lymphatic system carcinomas, soft tissue carcinoma, skin cancer, bone metastases, pediatric tumors, nonmalignant diseases, emergency in radio-oncology, supporting therapy, palliative therapy.

  14. Entwicklung und Anwendung neuer NMR-Methoden: Orientierungsmedien zur Strukturbestimmung mit anisotropen Parametern und Metabonomics

    OpenAIRE

    Büchler, Silke

    2014-01-01

    Das Ziel dieser Arbeit war die Entwicklung und Anwendung neuer Orientierungsmedien zur Strukturbestimmung mit anisotropen Parametern, sowie die Etablierung von Metabonomics-Studien an Flüssigzellkulturen und Reispflanzen.

  15. Radiotherapy, the experience of the patients; Strahlentherapie im Erleben der Patienten

    Energy Technology Data Exchange (ETDEWEB)

    Verres, R. [Heidelberg Univ. (Germany). Medizinische Universitaetsklinik (Ludolf-Krehl-Klinik); Klusmann, D. [eds.] [Hamburg Univ. (Germany). 1. Medizinische Universitaetsklinik

    1998-03-01

    For the patient, a radiotherapy means heavy physical and mental strain. Just like any other medical therapy, radiotherapy demands active cooperation of the patient based on mutual exchange between the patient and the doctor who, in addition to his medical responsibilities, has to develop awareness of the patient`s mental condition and the suitable response. This emphatic relationship may in turn and at times mean a heavy burden for the medical staff. The authors have evaluated for this book a great number of records, protocols and questionnaires accumulated in the course of their work with patients of the radiotherapy department. The book is intended as a source of reference and guidance and a help for all persons and staff involved, who have to cope with the situations encountered in daily work in the clinical departments. The book presents experience and information on a wide range of aspects and problems involved, as e.g.: Interpersonal relations, the patient`s feeling of being in the hands of technology, the difficulty to keep the delicate balance between confidence and non-confidence, the significance of good relations in the clinic for a successful outcome of the therapy, the ways how mental crises can be handled. The material also includes information on a variety of accompanying therapies, both for the actual treatment periods as well as for post-treatment periods where they may be late effects to be mastered. (orig./CB) 11 figs., 9 tabs. [Deutsch] Die Strahlentherapie ist fuer den Patienten mit hohen koerperlichen und seelischen Belastungen verbunden. Da die Mitwirkung des Patienten hier wie bei jeder Behandlung von grosser Bedeutung ist, muss sich der Arzt mit dessen psychischer Befindlichkeit ebenso gruendlich auseinandersetzen, wie mit seinem Gesundheitszustand. Hinzu kommt, dass das Mitfuehlen seelischer Konflikte des Patienten auf das Klinikpersonal zurueckwirken und einen erheblichen Druck erzeugen kann. Die Autoren haben zahlreiche Aufzeichnungen

  16. Aluminum phosphate shows more adjuvanticity than Aluminum hydroxide in recombinant hepatitis –B vaccine formulation

    Directory of Open Access Journals (Sweden)

    2008-08-01

    Full Text Available Background: Although a number of investigation have been carried out to find alternative adjuvants to aluminum salts in vaccine formulations, they are still extensively used due to their good track record of safety, low cost and proper adjuvanticity with a variety of antigens. Adsorption of antigens onto aluminum compounds depends heavily on electrostatic forces between adjuvant and antigen. Commercial recombinant protein hepatitis B vaccines containing aluminum hydroxide as adjuvant is facing low induction of immunity in some sections of the vaccinated population. To follow the current global efforts in finding more potent hepatitis B vaccine formulation, adjuvanticity of aluminum phosphate has been compared to aluminum hydroxide. Materials and methods: The adjuvant properties of aluminum hydroxide and aluminum phosphate in a vaccine formulation containing a locally manufactured hepatitis B (HBs surface antigen was evaluated in Balb/C mice. The formulations were administered intra peritoneally (i.p. and the titers of antibody which was induced after 28 days were determined using ELISA technique. The geometric mean of antibody titer (GMT, seroconversion and seroprotection rates, ED50 and relative potency of different formulations were determined. Results: All the adjuvanicity markers obtained in aluminum phosphate formulation were significantly higher than aluminum hydroxide. The geometric mean of antibody titer of aluminum phosphate was approximately three folds more than aluminum hydroxide. Conclusion: Aluminum phosphate showed more adjuvanticity than aluminum hydroxide in hepatitis B vaccine. Therefore the use of aluminum phosphate as adjuvant in this vaccine may lead to higher immunity with longer duration of effects in vaccinated groups.

  17. Volumes de calda e adjuvante no controle de plantas daninhas com glyphosate

    OpenAIRE

    Bueno,M.R.; Alves,G.S.; Paula,A.D.M.; Cunha,J.P.A.R.

    2013-01-01

    O sucesso de uma aplicação de herbicida está diretamente relacionado a uma boa deposição da calda no alvo, com o mínimo de perdas para o ambiente. Assim, o presente trabalho objetivou avaliar a deposição e o controle de plantas daninhas promovido pela aplicação de glyphosate em diferentes volumes de calda e com a adição do adjuvante nonil fenol etoxilado. O experimento foi conduzido em delineamento de blocos casualizados com quatro repetições, em esquema fatorial 3x2, sendo três volumes de ca...

  18. MISTURAS DE HERBICIDAS: EFEITOS DE ADJUVANTES NO CONTROLE DE PLANTAS INFESTANTES NA CULTURA DA SOJA

    Directory of Open Access Journals (Sweden)

    VALDEMIR ANTONIO PERESSIN

    1997-01-01

    Full Text Available Estudaram-se efeitos de misturas de graminicidas com latifolicidas, aplicados em pós-emergência, acrescidos ou não de seus respectivos adjuvantes, no controle de plantas infestantes na cultura da soja (Glycine max (L. Merrill cv. IAC-8, em condições de campo. Os tratamentos consistiram em quatro graminicidas (haloxifop-metil, HM; sethoxydim, S; quizalofop-etil, QE e fluazifop-p-butil, FpB e quatro latifolicidas (chlorimuron-etil, CE; fomesafen, Fom; fluoroglycofen, Flu e lactofen, Lac, aplicados isoladamente e em misturas, além das testemunhas com e sem convivência da cultura com a comunidade infestante. Os resultados mostraram que os adjuvantes, de maneira geral, intensificaram a injúria dos herbicidas. Os graminicidas mais eficazes, aplicados isoladamente ou em misturas, no controle de Eleusine indica e de monocotiledôneas, foram HM, QE e FpB. Não houve diferenças significativas no controle de Digitaria horizontalis entre os quatro graminicidas isolados; porém, as melhores misturas foram as que utilizaram os graminicidas QE ou HM. Para controle de Mollugo verticillata, os melhores tratamentos foram obtidos com Lac aplicado isoladamente e com as misturas de QE, S ou HM com Fom e seus respectivos adjuvantes. As misturas de tanque apresentaram efeitos predominantemente antagonísticos no controle de E. indica, D. horizontalis e monocotiledôneas. Efeitos estatis-ticamente antagonísticos e sinergísticos no controle de M. verticillata foram obtidos, respec-tivamente, nas misturas de tanque com Lac e com Fom. Uma possível interação entre os adjuvantes e as misturas de herbicidas ocorreu nas avaliações de controle para E. indica, quando as misturas de S ou de HM foram usadas com ou sem adjuvantes. Os tratamentos com herbicidas não influíram na produção do cultivar de soja IAC-8.Mixtures of narrowleaf and broadleaf herbicides, with or without their respective surfactants, were evaluated as to postemergence selectivity for weed

  19. KRISENZUSTÄNDE UND ANWENDUNG VON ZWANGSMASSNAHMEN IN DER PSYCHIATRIE

    Directory of Open Access Journals (Sweden)

    Vesna Šendula Jengić

    2017-01-01

    Full Text Available In der Arbeit wird über die Phänomene der Aggressivität und Gewalt bei Menschen diskutiert, wobei man besonderen Wert auf die Personen mit seelischen Störungen legt. Krisenzustände und Gewaltverhalten gibt es nicht nur in der Psychiatrie. Es kann immer zu einem solchem Zustand und Verhalten kommen und jeder kann unter bestimmten Umständen sowohl Opfer als auch Täter sein. Multikausalität und Komplexität sowie auch individuelle Umstände und situationsbezogene Faktoren, welche zum Gewaltverhalten führen können, haben nur geringen Prognosekraft. Statistische Indikatoren andererseits können falsch positive und falsch negative Ergebnisse verbergen, wobei ein Fehler in der Einschätzung das Risiko zum Erscheinen eines Verhaltens drastisch erhöhen oder zum unrechtfertigten Entziehung der Freiheit führen kann. Zwangsmaβnahmen in der Psychiatrie sind nur ausnahmsweise anzuwenden, und zwar, wenn ein gefährliches Verhalten direkt das Leben und die Gesundheit einer Person oder einer Umgebung gefährdet. Darüber hinaus ist die Dauer von Zwangsmaβnahmen auch beschränkt. Die Gesetzesregulative, insbesondere das Gesetz über den Schutz von Personen mit seelischen Störungen (Amtsblatt der Republik Kroatien Nr. 76/2014 und die Ordnung über die Arten und die Weise der Anwendung von Zwangsmaβnahmen gegenüber den Personen mit schwierigen seelischen Störungen (Amtsblatt der Republik Kroatien Nr. 16/2015, dient als zusätzlicher Schutz der Rechte dieser Patientengruppe und schreibt die Arten und die Weise der Anwendung von Zwangsmaβnahmen sowie auch die Vorgehensweise. Zusätzliche Richtlinien und Vorgehensstrategien wurden auch von den Gesellschaften für Psychiatrie gegeben. In der Arbeit wird betont, dass bessere Bedingungen, Infrastruktur und Arbeitskräfte sowie auch ständige Entwicklung und Bewertung der Arbeitsqualität in der Psychiatrie erforderlich sind. Abschlieβend werden Standards und ethische Fragen in Betracht gezogen, wie

  20. [Postoperative adjuvante Therapie mit einem Mistelextrakt (Viscum album ssp. album) bei Hündinnen mit Mammatumoren].

    Science.gov (United States)

    Biegel, Ulrike; Stratmann, Nina; Knauf, Yvonne; Ruess, Katja; Reif, Marcus; Wehrend, Axel

    2017-01-01

    Hintergrund: Canine Mammatumoren (CMT) sind wegen ihrer Häufigkeit und hohen Malignitätsrate eine Herausforderung für die Veterinärmedizin. Bisher ist noch keine postoperative adjuvante Therapie als wirksamer Standard etabliert und in den nächsten Jahren wohl auch nicht zu erwarten. Zusätzlich ist die Frage nach der Verträglichkeit einer adjuvanten Therapie mit Erhaltung oder Verbesserung der Lebensqualität (LQ) wichtig. Die Therapie mit Mistelextrakten (Viscum album L.; VAE) ist in der Humanonkologie nach adjuvanter Tumorbasistherapie (Chemotherapie und Bestrahlung) eine sehr häufig verwendete, zusätzliche adjuvante Behandlungsmethode. Auch bei verschiedenen Tierarten werden inzwischen Mistelpräparate in der Onkologie erfolgreich angewendet. Methoden: Überprüfung von Wirkung und Nutzen einer postoperativen, adjuvanten Misteltherapie beim CMT sowie Erfassung der LQ unter der VAE-Behandlung. Ausgewertet wurden 56 Hündinnen mit Mammaadenokarzinom, 33 ausschließlich operierte Kontrolltiere und 23 operierte Tiere, die adjuvant VAE erhielten. Ergebnisse: Die mediane Überlebenszeit (MST) aller Tiere (n = 56) betrug 32 Monate (Interquartilbereich 13-51 Monate). Im deskriptiven Vergleich der Überlebenszeiten (ST) nach Kaplan-Meier waren nach 12, 24, 36 bzw. 48 Monaten noch 24, 20, 15 bzw. 5 Hündinnen (entsprechend 72,7%, 60,6%, 45,1%, 12,4%) der Kontrollgruppe sowie 19, 14, 11 und 1 Hündin (82,6%, 60,9%, 47,8%, 4,3%) der VAE-Gruppe am Leben. Die VAE-Therapie führte zu einem geringeren Gesamtversterberisiko, das statistisch nicht signifikant war (Hazard Ratio (HR) 0,530, 95%-Konfidenzintervall (KI) 0,222-1,262; p = 0,15). Tendenziell (p = 0,07) zeigte sich eine Verringerung des tumorbedingten Sterberisikos auf 25% (HR 0,251, 95%-KI 0,056-1,122). Schlussfolgerungen: Es kann eine Tendenz zur Senkung des tumorbedingten Sterberisikos der VAE-Gruppe bei guter Verträglichkeit der Therapie angenommen werden. Die LQ der Tiere blieb über die gesamte

  1. IFRS 8 OPERATING SEGMENTS: Eine Untersuchung der erstmaligen Anwendung in der Schweiz

    OpenAIRE

    Meyer, C; Weiss, S

    2010-01-01

    Seit dem 1. Januar 2009 sind kotierte IFRS-Anwender verpflichtet, eine Segmentberichterstattung nach IFRS 8 zu erstellen. Anhand einer Analyse der Geschäftsberichte 2009 der an der SIX Swiss Exchange kotierten Unternehmen soll ein Überblick über die erstmalige Anwendung von IFRS 8 "Operating Segments" in der Schweiz gewonnen werden.

  2. Neodadjuvante und adjuvante Kurzzeit-Hormontherapie in Kombination mit konformaler HDR-Brachytherapie beim Prostatakarzinom

    Directory of Open Access Journals (Sweden)

    Martin T

    2004-01-01

    Full Text Available Zielsetzung: Auswertung der Behandlungsergebnisse der neoadjuvanten und adjuvanten Kurzzeit-Hormontherapie kombiniert mit konformaler HDR-Brachytherapie und externer Radiotherapie beim Prostatakarzinom. Patienten und Methoden: Von 01/97 bis 09/99 behandelten wir 102 Patienten mit Prostatakarzinomen im Stadium T1–3 N0 M0. Im Stadium T1–2 befanden sich 71, im Stadium T3 31 Patienten. Der mediane prätherapeutische PSA-Wert betrug 15,3 ng/ml. Nach ultraschallgesteuerter transrektaler Implantation von vier Afterloadingnadeln erfolgte die CT-gestützte 3D-Brachytherapie- Planung. Alle Patienten erhielten vier HDR-Implantate mit einer Referenzdosis von 5 Gy oder 7 Gy pro Implantat. Die Zeit zwischen jedem Implantat betrug jeweils 14 Tage. Nach der Brachytherapie folgte die externe Radiotherapie bis 39,6 Gy oder 45,0 Gy. Alle Patienten erhielten eine neoadjuvante und adjuvante Kurzzeit-Hormontherapie, die 2–19 Monate vor der Brachytherapie eingeleitet und 3 Monate nach Abschluß der externen Radiotherapie abgesetzt wurde (mediane Dauer: 9 Monate. Ergebnisse: Die mediane Nachbeobachtungszeit war 2,6 Jahre (range: 2,0–4,1 Jahre. Die biochemische Kontrollrate betrug 82 % nach 3 Jahren. Bei 14/102 Patienten registrierten wir ein biochemisches Rezidiv, bei 5/102 Patienten ein klinisches Rezidiv. Das Gesamtüberleben betrug 90 %, das krankheitsspezifische Überleben 98,0 % nach 3 Jahren. Ein Patient entwickelte eine prostato-urethro-rektale Fistel als späte Grad 4-Toxizität. Akute Grad-3 Toxizitäten traten bei 4 %, späte Grad-3 Toxizitäten bei 5 % der Patienten auf. Schlußfolgerung: Die neoadjuvante und adjuvante Kurzzeit-Hormontherapie kombiniert mit konformaler HDR-Brachytherapie und externer Radiotherapie erweist sich als sichere und wirksame Behandlungsmodalität beim Prostatakarzinom mit minimalen behandlungsbedingten Toxizitäten und einer vielversprechenden biochemischen Kontrollrate nach medianer Nachbeobachtungszeit von 2,6 Jahren.

  3. Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity.

    Science.gov (United States)

    Tacken, Paul J; Zeelenberg, Ingrid S; Cruz, Luis J; van Hout-Kuijer, Maaike A; van de Glind, Gerline; Fokkink, Remco G; Lambeck, Annechien J A; Figdor, Carl G

    2011-12-22

    Effective vaccines consist of 2 components: immunodominant antigens and effective adjuvants. Whereas it has been demonstrated that targeted delivery of antigens to dendritic cells (DCs) improves vaccine efficacy, we report here that co-targeting of TLR ligands (TLRLs) to DCs strongly enhances adjuvanticity and immunity. We encapsulated ligands for intracellular TLRs within biodegradable nanoparticles coated with Abs recognizing DC-specific receptors. Targeted delivery of TLRLs to human DCs enhanced the maturation and production of immune stimulatory cytokines and the Ag-specific activation of naive CD8(+) T cells. In vivo studies demonstrated that nanoparticles carrying Ag induced cytotoxic T-lymphocyte responses at 100-fold lower adjuvant dose when TLRLs were co-encapsulated instead of administered in soluble form. Moreover, the efficacy of these targeted TLRLs reduced the serum cytokine storm and related toxicity that is associated with administration of soluble TLRLs. We conclude that the targeted delivery of adjuvants may improve the efficacy and safety of DC-based vaccines.

  4. The adjuvanticity of ophiopogon polysaccharide liposome against an inactivated porcine parvovirus vaccine in mice.

    Science.gov (United States)

    Fan, Yunpeng; Ma, Xia; Hou, Weifeng; Guo, Chao; Zhang, Jing; Zhang, Weimin; Ma, Lin; Song, Xiaoping

    2016-01-01

    In this study, the adjuvant activity of ophiopogon polysaccharide liposome (OPL) was investigated. The effects of OPL on the splenic lymphocyte proliferation of mice were measured in vitro. The results showed that OPL could significantly promote lymphocyte proliferation singly or synergistically with PHA and LPS and that the effect was better than ophiopogon polysaccharide (OP) at most of concentrations. The adjuvant activities of OPL, OP and mineral oil were compared in BALB/c mice inoculated with inactivated PPV in vivo. The results showed that OPL could significantly enhance lymphocyte proliferation, increase the proportion of CD4(+) and CD8(+) T cells, improve the HI antibody titre and specific IgG response, and promote the production of cytokines, and the efficacy of OPL was significantly better than that of OP. In addition, OPL significantly improved the cellular immune response compared with oil adjuvant. These results suggested that OPL possess superior adjuvanticity and that a medium dose had the best efficacy. Therefore, OPL can be used as an effective immune adjuvant for an inactivated PPV vaccine. Copyright © 2015. Published by Elsevier B.V.

  5. Hydrogen in motor car engineering. Production, storage, uses; Wasserstoff in der Fahrzeugtechnik. Erzeugung, Speicherung, Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Eichlseder, H.; Klell, M.

    2008-07-01

    The book presents a general outline of the various aspects of properties, production, storage and application of hydrogen at university level. The focus is on the thermodynamic aspects of hydrogen storage andon its applications in transportation and power supply. In particular, car engines and fuel cells are gone into, and the state of the art is outlined with reference to research projects of TU Graz university and HyCentA. Apart from the technical aspects, also the history and possible future trends are presented. [German] Dieses Buch bietet einen allgemeinen Ueberblick ueber die verschiedenen Aspekte von Eigenschaften, Erzeugung, Speicherung und Anwendung von Wasserstoff auf Hochschulniveau. Schwerpunkte liegen auf der Thermodynamik der Speicherung von Wasserstoff sowie auf der Anwendung in der Verkehrstechnik und in der Energietechnik. Speziell wird die Anwendung in der Verbrennungskraftmaschine und in der Brennstoffzelle behandelt, wobei mit Bezug auf Forschungsvorhaben an der TU Graz und dem HyCentA der aktuelle Stand der Technik fundiert dargestellt wird. Neben einer technischen Vertiefung werden auch die geschichtliche und die moegliche kuenftige Entwicklung angesprochen.

  6. Palliative radiotherapy. Ranking within an interdisciplinary treatment concept in case of advanced tumor disease; Palliative Strahlentherapie. Rolle im interdisziplinaeren Behandlungskonzept bei fortgeschrittenem Tumorleiden

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H. [Krupp Krankenanstalten Gemeinnuetzige GmbH, Essen (Germany). Klinik fuer Strahlentherapie und Nuklearmedizin

    1998-10-23

    Many tumor-induced symptoms can be alleviated by suitable irradiation in a direct, effective and sparing manner. The clinical response amounts to 80% and is independent of tumor histology. Careful diagnosis and accurate localisation of the causes of symptoms as well as exact therapy planning and execution are required. Based on individual dose planning harmonising single dosis and total dosis, pin-pointed definition of target areas, and application of modern planning and irradiation techniques, palliative radiotherapy is able to achieve long-term improvement with neglectible side-effects, sometimes within only a few days or weeks. It is a valuable part of a consistant therapy concept that is tailored to the individual needs of a patient, by cooperative action of experts from a variety of medical disciplines, intended to optimize the qulity of life of patients, and sometimes may exclude conventional radiotherapy. (orig./CB) [Deutsch] Viele tumorbedingten Symptome koennen mit Strahlentherapie kausal wirksam, effektiv und schonend behandelt werden. Das klinische Ansprechen betraegt 80% und ist unabhaengig von der Histologie des Tumors. Eine sorgfaeltige Indikationsstellung und genaue Lokalisation der Symptomursache sowie exakte Planung und Durchfuehrung der Strahlentherapie sind Bedingung. Mit einer individuellen Anpassung der Einzel- und Gesamtdosis, des Zielvolumens und dem Einsatz moderner Planungs- und Bestrahlungstechniken gelingt es, oft innerhalb weniger Tage bis Wochen eine langanhaltende Symptombesserung ohne wesentliche Nebenwirkungen zu erzielen. Die palliative Strahlentherapie ist dabei Teil eines Gesamtbehandlungskonzeptes, das interdisziplinaer abgestimmt ist und eine optimale Lebensqualitaet fuer den Tumorpatienten anstrebt, manchmal auch unter Verzicht auf eine Therapie. (orig.)

  7. Genetic adjuvantation of recombinant MVA with CD40L potentiates CD8 T cell mediated immunity

    Directory of Open Access Journals (Sweden)

    Henning eLauterbach

    2013-08-01

    Full Text Available Modified vaccinia Ankara (MVA is a safe and promising viral vaccine vector that is currently investigated in several clinical and pre-clinical trials. In contrast to inactivated or sub-unit vaccines, MVA is able to induce strong humoral as well as cellular immune responses. In order to further improve its CD8 T cell inducing capacity, we genetically adjuvanted MVA with the coding sequence of murine CD40L, a member of the tumor necrosis factor (TNF superfamily. Immunization of mice with this new vector led to strongly enhanced primary and memory CD8 T cell responses. Concordant with the enhanced CD8 T cell response, we could detect stronger activation of dendritic cells and higher systemic levels of innate cytokines (including IL-12p70 early after immunization. Interestingly, acquisition of memory characteristics (i.e., IL-7R expression was accelerated after immunization with MVA-CD40L in comparison to non-adjuvanted MVA. Furthermore, the generated CTLs also showed improved functionality as demonstrated by intracellular cytokine staining and in vivo killing activity. Importantly, the superior CTL response after a single MVA-CD40L immunization was able to protect B cell deficient mice against a fatal infection with ectromelia virus. Taken together, we show that genetic adjuvantation of MVA can change strength, quality and functionality of innate and adaptive immune responses. These data should facilitate a rational vaccine design with a focus on rapid induction of large numbers of CD8 T cells able to protect against specific diseases.

  8. Espectro de gotas de pontas de pulverização com adjuvantes de uso agrícola

    OpenAIRE

    Cunha,J.P.A.R.; Bueno,M.R.; Ferreira,M.C.

    2010-01-01

    O sucesso de uma boa aplicação de produtos fitossanitários depende da sinergia entre fatores como tamanho de gota, tipo de ponta, pressão, volume e composição da calda e características do alvo. Assim, o objetivo deste trabalho foi avaliar o espectro de gotas produzidas por pontas de jato plano defletor (TT 11002) e jato plano defletor com indução de ar (TTI 11002), com diferentes adjuvantes adicionados à calda de pulverização, pela técnica de difração de raio laser. O experimento foi conduzi...

  9. Analgesia adjuvante e alternativa Analgesia adyuvante y alternativa Adjuvant and alternative analgesia

    Directory of Open Access Journals (Sweden)

    Nilton Bezerra do Vale

    2006-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Embora a dor aguda e a crônica sejam habitualmente controladas com intervenções farmacológicas, 14 métodos complementares de analgesia adjuvante e alternativa (AAA podem reduzir o uso e abuso na prescrição de analgésicos e diminuir os efeitos colaterais que eventualmente comprometem o estado fisiológico do paciente. CONTEÚDO: Todos os mecanismos antiálgicos atuam através da via espinal de controle da comporta de Melzack e Wall e/ou através da transdução do sinal nos sistemas de neurotransmissão e neuromodulação central relacionados com analgesia, relaxamento e humor: peptidérgico, monaminérgico, gabaérgico, colinérgico e canabinóide. A analgesia adjuvante complementar é habitualmente utilizada nos tratamentos fisiátricos, ortopédicos, reumatológicos, obstétricos e com acupuntura. A analgesia alternativa complementar pode potencializar os métodos analgésicos convencionais, a exposição à luz do sol matutino, luz e cores sob luz artificial, o tempo (T - anestésicos gerais mais potentes à noite, opióides de manhã e anestésicos locais à tarde, dieta, bom humor e riso, espiritualidade, religião, meditação, musicoterapia, hipnose e efeito placebo. CONCLUSÕES: Se a dor aguda é um mecanismo de defesa, a dor crônica é um estado patológico desagradável relacionado com a depressão endógena e a uma baixa qualidade de vida. É importante estabelecer relações interdisciplinares entre a Medicina adjuvante e alternativa nas terapias analgésicas e antiinflamatórias clássicas.JUSTIFICACIÓN Y OBJETIVOS: Aunque el dolor agudo y el crónico sean habitualmente controlados con intervenciones farmacológicas, 14 métodos complementarios de analgesia adyuvante y alternativa (AAA pueden reducir el uso y el abuso en la prescripción de analgésicos y disminuir los efectos colaterales que eventualmente comprometen el estado fisiológico del paciente. CONTENIDO: Todos los mecanismos anti

  10. Radiotherapy of heterotopic bone formation in patients with paraplegia. Preliminary results; Strahlentherapie heterotoper Ossifikationen bei Querschnittsgelaehmten. Praeliminaere Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Sautter-Bihl, M.L. [Klinik fuer Strahlentherapie, Staedtisches Klinikum Karlsruhe (Germany); Liebermeister, E. [Klinik fuer Strahlentherapie, Staedtisches Klinikum Karlsruhe (Germany); Heinze, H.G. [Klinik fuer Strahlentherapie, Staedtisches Klinikum Karlsruhe (Germany); Nanassy, A. [Klinik fuer Orthopaedie, Rehabilitationskrankenhaus Langensteinbach (Germany); Stoltze, D. [Klinik fuer Orthopaedie, Rehabilitationskrankenhaus Langensteinbach (Germany)

    1995-08-01

    In 20 patients with paralysis, 25 regions were irradiated with (mostly) 10 Gy in single fractions of 2 to 2.5 Gy using 8 MW photons. In 15 patients radiotherapy was performed as a primary treatment in the status of myositis; 7 patients were treated after (subtotal) resection of already manifest ossifications (2 patients were treated twice, primarily and postoperatively). In a minimum follow-up 12 weeks, none of the 20 irradiated patients showed any progression of the developing or already manifest ossification; thus mobilisation and rehabilitation could be carried out as desired. No side effects occurred. The preliminary results of the present study suggest that radiotherapy is an effective local treatment with minimal side effects for the prevention of heterotopic bone formation in patients with paraplegia. (orig.) [Deutsch] Bei 20 Patienten (18 Maenner, zwei Frauen, Alter 19 bis 62 Jahre) mit Querschnittssyndrom wurden 25 Regionen mit ueberwiegend 10 Gy a 2 bis 2,5 Gy Einzeldosis mit 8-MW-Photonen bestrahlt. Die Radiatio erfolgte bei 15 Patienten als Primaerprophylaxe im entzuendlichen Stadium, bei sieben Patienten sekundaer nach (subtotaler) Resektion von Ossifikationen (zwei Patienten wurden sowohl primaer als auch sekundaer bestrahlt). Bei einer Mindestnachbeobachtungszeit von zwoelf Wochen trat in keinem Fall eine Progression der sich entwickelnden bzw. bereits bestehenden heterotopen Ossifikationen auf: saemtliche Patienten konnten wunschgemaess mobilisiert und im Rahmen ihrer neurologischen Ausfaelle rehabilitiert werden. Nebenwirkungen traten nicht auf. Die vorliegende praeliminaeren Ergebnisse deuten hin, dass die Strahlentherapie eine effektive und nebenwirkungsarme lokale Therapie zur Verhinderung heterotoper Ossifikationen beim Querschnittssyndrom darstellt. (orig.)

  11. Clinical nuclear medicine in radiation therapy - state and perspectives; Klinische Nuklearmedizin in der Strahlentherapie - Stand und Perspektiven

    Energy Technology Data Exchange (ETDEWEB)

    Schultze, J. [Kiel Univ. (Germany). Klinik fuer Strahlentherapie (Radioonkologie)

    1995-08-01

    Clinical nuclear medicine has severely changed due to the technical and pharmacological developments within the last 15 years. An evaluation of the importance of nuclear medicine for treatment planning purposes in radiation therapy revealed in 20.6% of the cases relevant new information due to the scans. That nevertheless the demand for nuclearmedical examinations is decreasing might be a result of an increasing alienation between nuclear medicine and referring physicians of other specialities. Therefore a reapproach of nuclear medicine with her main clinical partners is desireable which could be achieved e.g. by exchange of rotating house officers, participation in tumor conferences and consiliary statements to scan indications. (orig.) [Deutsch] Die klinische Nuklearmedizin hat sich durch die technischen und pharmakologischen Entwicklungen der letzten 15 Jahre erheblich veraendert. Eine Evaluation der Bedeutung nuklearmedizinischer Verfahren fuer die Bestrahlungsplanung in der Strahlentherapie hat in 20,6% der Faelle eine untersuchungsbedingte, planungsrelevante Information erbracht, auf die nicht verzichtet werden konnte. Dass die Nachfrage nach nuklearmedizinischen Untersuchungen in diesem Bereich trotzdem ruecklaeufig ist, duerfte Ergebnis einer zunehmenden Entfremdung der Zuweiser aus den verwandten Faechern von der Nuklearmedizin sein. Es ist deshalb eine Wiederannaeherung der Nuklearmedizin an ihre klinischen Hauptpartner wuenschenswert, die durch Austausch von Rotationsassistenten, die Beteiligung an Tumorkonferenzen und die konsiliarische Stellungnahme zu Untersuchungsindikationen erreicht werden koennte. (orig.)

  12. Anwendung stabiler Isotope zur Beschreibung des mikrobiellen Abbaus organischer Schadstoffe in kontaminierten Aquiferen

    OpenAIRE

    Vieth, Andrea

    2003-01-01

    Der mikrobielle in-situ Abbau organischer Schadstoffe ist mit einer Änderung der Isotopenverhältnisse (12C/13C; H/D) verbunden. Das Ausmaß der Isotopenfraktionierung ist abhängig von der initialen biochemischen Reaktion und variiert mit der Größe des Substratmoleküls bzw. der Anzahl der Kohlenstoff- bzw. Wasserstoffatome. Für die Anwendung dieses Isotopenkonzepts zur Beschreibung des mikrobiellen Abbaus von Schadstoffen im Grundwasser muss ausgeschlossen werden können, dass andere Prozesse ei...

  13. Evaluation von Bildungssoftware im Spannungsfeld von Objektivität und praktischer Anwendung

    Directory of Open Access Journals (Sweden)

    Cornelia Biffi

    2002-05-01

    Full Text Available Das Angebot an Bildungs- bzw. Lernsoftware umfasst eine breite Palette von sehr unterschiedlichen Produkten. Eigentliche Unterrichtssoftware, die speziell für den Unterricht hergestellt und auf Lehrmittel und Curriculum abgestimmt ist, gibt es kaum. Im Projekt «Lernsoftware Evaluation» des Pestalozzianums Zürich ermitteln Lehrpersonen die Qualität von Bildungssoftware, indem sie diese im Unterricht einsetzen und anhand eines Kriterienrasters beurteilen. Eine Analyse der in der Evaluation generierten Daten belegt die Problematik des Anspruchs einer objektiven Qualitätsbeurteilung. Es werden die Probleme bei der Anwendung von Kriterienraster und Beurteilungsmodus aufgezeigt und ermittelt, worin die subjektiven Qualitätsmassstäbe der Evaluierenden begründet sind. Diese Ausführungen sind Teil eines Forschungsprojekts für die Weiterentwicklung einer theoretisch fundierten, aber dennoch praxisnahen Evaluation von Bildungssoftware.

  14. Conformal radiation therapy of localized prostate cancer: acute tolerance and early evaluation of effectiveness; Konformierende Strahlentherapie des lokalisierten Prostatakarzinoms: Akute Toleranz und fruehe Wirksamkeit

    Energy Technology Data Exchange (ETDEWEB)

    Zierhut, D. [Klinische Radiologie, Radiologische Universitaetsklinik Heidelberg (Germany); Flentje, M. [Klinische Radiologie, Radiologische Universitaetsklinik Heidelberg (Germany); Sroka-Perez, G. [Klinische Radiologie, Radiologische Universitaetsklinik Heidelberg (Germany); Rudat, V. [Klinische Radiologie, Radiologische Universitaetsklinik Heidelberg (Germany); Engenhart-Cabillic, R. [Klinische Radiologie, Radiologische Universitaetsklinik Heidelberg (Germany); Wannenmacher, M. [Klinische Radiologie, Radiologische Universitaetsklinik Heidelberg (Germany)

    1997-02-01

    Aim: In a prospective trial early effectiveness and acute toxicity of conformal 3D-planned radiotherapy for localized prostate cancer was quantified using dose-volume-histogramms and evaluated with respect of treatment technique. Results: Eleven patients (of 32) had none, 15 mild (RTOG grade 1) and 6 moderate symptoms (RTOG grade 2, mainly diarrhoea, dysuria and polyuria). Acute complications leading to treatment interruption did not occur. In 16 patients symptoms disappeared within 6 weeks after radiotherapy. Only 2 men had symptoms which lasted longer than 3 months and were endoscopically examined. Up to now no late complications were detected. Incidence and severity of toxicity was significantly (p<0,05) related to the size of treatment volume. Akute toxicity was found to depend statistically significant (p<0,05) on the proportional volume of bladder and rectum, irradiated with more than 35 Gy. In 81% of the patients with pretherapeutic elevated PSA levels normalisation of PSA was observed. Overall mean PSA levels of 15.7{+-}22.6 {mu}g/l at the beginning of radiotherapy fell to 2.1{+-}3.7 {mu}g/l 6 weeks after irradiation. Only 1 Patient relapsed locally 22 months after radiation therapy. Conclusion: We conclude that due to modern 3D-planned conformal techniques with optimization of treatment dose and improved protection of critical organs such as urinary bladder and rectum, radiotherapy allows an effective and well tolerated therapy of localized prostatic carcinoma. (orig./VHE) [Deutsch] Ziel: Quantifizierung der fruehen Wirksamkeit und akuten Toxizitaet der 3D-geplanten und konformierenden Strahlentherapie des lokalisierten Prostatakarzinoms mittels Dosis-Volumen-Histogramm sowie Untersuchung der Abhaengigkeit von der Bestrahlungstechnik in einer prospektiven Studie. Ergebnisse: Elf Patienten hatten keine, 15 leichte (RTOG Grad I) und sechs maessiggradige Nebenwirkungen (RTOG Grad II, meist Diarrhoe, Dysurie und Polyurie). Bei keinem Patienten musste die

  15. Application of C-arm computed tomography in cardiology; Kardiale Anwendung der C-Arm-Computertomographie

    Energy Technology Data Exchange (ETDEWEB)

    Rieber, J. [Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Campus Innenstadt, Abteilung fuer Kardiologie, Medizinische Poliklinik, Muenchen (Germany); Rohkohl, C. [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Lehrstuhl fuer Mustererkennung, Department Informatik, Erlangen (Germany); Siemens AG, Healthcare Sector, Forchheim, Forchheim (Germany); Lauritsch, G. [Siemens AG, Healthcare Sector, Forchheim, Forchheim (Germany); Rittger, H. [Krankenhaus Coburg, Abteilung fuer Kardiologie, Coburg (Germany); Meissner, O. [Siemens AG, Healthcare Sector, Forchheim, Forchheim (Germany); Klinikum der Ludwig-Maximilians-Universitaet Muenchen, Institut fuer Klinische Radiologie, Muenchen (Germany)

    2009-09-15

    C-arm computed tomography is currently being introduced into cardiac imaging and offers the potential for three-dimensional imaging of the cardiac anatomy within the interventional environment. This detailed view is necessary to support complex interventional strategies, such as transcutaneous valve replacement, interventional therapy of atrial fibrillation, implantation of biventricular pacemakers and assessment of myocardial perfusion. Currently, the major limitation of this technology is its insufficient temporal resolution which limits the visualization of fast moving parts of the heart. (orig.) [German] Durch die Entwicklung der C-Arm-Computertomographie- (CACT-)Angiographie ist es erstmals moeglich, waehrend einer Herzkatheteruntersuchung eine detaillierte dreidimensionale Darstellung der kardialen Anatomie zu erhalten. Derartige zusaetzliche Informationen koennten die Durchfuehrung der immer komplexer werdenden Strategien der interventionellen Kardiologie wirkungsvoll unterstuetzen. Hierzu zaehlen u. a. der transkutane Klappenersatz, die interventionelle Behandlung von Vorhofflimmern, die Implantation biventrikulaerer Schrittmacher sowie die Beurteilung der Myokardperfusion. Die derzeit groesste Limitation dieser Methode ist die relativ geringe zeitliche Aufloesung, die aufgrund der Bewegung des Herzens die Anwendung dieser Technologie einschraenkt. (orig.)

  16. Biofuels - Properties and application experience; Biokraftstoffe - Eigenschaften und Erfahrungen bei der Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Schmiedel, H.P.

    2002-12-01

    The European Union wants to promote the use of renewable raw materials also in the traffic sector in order to meet the internationally committed reduction of carbon dioxide emissions. At the same time a new market shall be created for farming and jobs shall be secured. Fatty acid methyl esters in the diesel market and ethanol and ethyl tertiary butyl ether (ETBE) in gasoline are discussed as compounds that can be produced from renewable raw materials and be applied as fuels in the short term. This literature survey deals with the extent of CO{sub 2} / greenhouse gas emission reductions, the availability of biofuels and summarizes the economical and technical experiences obtained so far with their application. The use of pure vegetable oils, dimethylether and pyrolysis oil is also briefly covered. (orig.) [German] Die EU will auch im Verkehrsbereich den Einsatz nachwachsender Rohstoffe foerdern, um die international zugesagte Reduzierung der Kohlendioxid-Emissionen zu erreichen. Gleichzeitig sollen damit der Landwirtschaft ein neuer Markt eroeffnet und Arbeitsplaetze gesichert werden. Fettsaeuremethylester fuer den Dieselbereich sowie Ethanol und Ethyltertiaerbutylether (ETBE) fuer Ottokraftstoff werden als Verbindungen genannt, die aus nachwachsenden Rohstoffen gewonnen und kurzfristig als Kraftstoff eingesetzt werden koennen. Die vorliegende Literaturstudie beleuchtet den Umfang der CO{sub 2}- bzw. Klimagasreduktion, die Verfuegbarkeit der Biokraftstoffe und fasst die oekonomischen und technischen Erfahrungen zusammen, die bisher in ihrer Anwendung erhalten wurden. Die Nutzung von reinen Pflanzenoelen, Dimethylether und Pyrolyseoel wird gestreift. (orig.)

  17. Retrospective results of radiation therapy of the Eustachian tube in chronic otitis media; Retrospektive Ergebnisse der perkutanen Strahlentherapie der Tuba Eustachii bei chronischer Otitis media

    Energy Technology Data Exchange (ETDEWEB)

    Schultze, J.; Reinke, C.; Kimmig, B. [Klinik fuer Strahlentherapie (Radioonkologie), Universitaetsklinikum Kiel (Germany); Frese, K.A. [Klinik fuer Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Universitaetsklinikum Kiel (Germany)

    2003-01-01

    Methoden: Zwischen 1980 und 1997 wurden 66 Patienten vorgestellt. Der Altersmedian war bei 58 Jahren. Klinisch lag bei allen Patienten eine Hoerminderung vor, 35 Patienten gaben Schmerzen, 21 weitere Ohrfluss an. 20 Patienten klagten ueber rezidivierende Infekte. Die Beschwerden bestanden im Median 4,7 Jahre, die primaer konservative (Adstringentien, Antibiotika) und operative Therapie (Parazentese, Paukenroehrchen, Tympanoplastik) hatte keine dauerhafte Besserung erbracht. Bei 40 der 66 Patienten erfolgte schliesslich eine perkutane Radiotherapie beider Tuben ueber opponierende Stehfelder und eine Gesamtdosis von 6 Gy bei Einzeldosen von 1 Gy dreimal woechentlich. Unter den Ausschlussgruenden fuer eine Strahlentherapie waren Ablehnung des Patienten (neunmal), radiogene Vorbelastungen (sechsmal) und spontane Besserung nach initialer Vorstellung. Die Ergebnisevaluation erfolgte ueber die subjektiven Angaben der Patienten und den HNO-aerztlichen Untersuchungsbefund. Ergebnisse: Es traten keine Nebenwirkungen auf. 28 der 40 bestrahlten Patienten (70%) gaben eine auch HNO-aerztlich objektivierbare symptomatische Besserung an. In der Gruppe der nicht bestrahlten 26 Patienten, von denen 22 evaluiert werden konnten, gaben 16 (72%) unveraendert Beschwerden und ein Persistieren der Otitis media an. In einer Subgruppenanalyse hinsichtlich der Beschwerdedauer zeigte sich die Strahlentherapie bei den akuten und subakuten Faellen als sehr effektiv, waehrend die Patienten in einem chronischen Stadium, mehr als 5 Jahre nach Diagnosestellung, kaum noch auf die Radiotherapie reagierten. Schlussfolgerung: Die Radiotherapie ist eine geeignete Methode zur symptomatischen Besserung der therapierefraktaeren chronischen Otitis media. Eine Dosis von 6 Gy scheint ausreichend zum Erreichen einer antiinflammatorischen Wirkung. Die Strahlentherapie sollte bereits nach Versagen der initial erfolglosen konservativen und operativen Therapie durchgefuehrt werden. (orig.)

  18. Methandiid-basierte Cabenkomplexe: Von ihrer Synthese und elektronischen Struktur zur Anwendung in Bindungsaktivierungsreaktionen und katalytischen Umsetzungen

    OpenAIRE

    Weismann, Julia

    2015-01-01

    Die vorliegende Arbeit beschäftigt sich mit der Anwendung des Sulfonyl-stabilisierten Methandiids 20-Li2 als Ligand in Übergangsmetallkomplexen. Dabei konnte 20-Li2 mit ver-schiedenen Übergangsmetallhalogeniden in Salzmetathesereaktionen umgesetzt werden. Insgesamt wiesen die synthetisierten Methandiid-basierten Komplexe flexible Bindungsverhältnisse bezüglich der MC-Bindung und unterschiedliche Koordinationsmodi der Sulfonyl-Gruppe auf, die die Stabilität und Reaktivität der Komplexe signif...

  19. Espectro de gotas de pontas de pulverização com adjuvantes de uso agrícola Droplet spectra of spray nozzles with agricultural adjuvants

    Directory of Open Access Journals (Sweden)

    J.P.A.R. Cunha

    2010-01-01

    Full Text Available O sucesso de uma boa aplicação de produtos fitossanitários depende da sinergia entre fatores como tamanho de gota, tipo de ponta, pressão, volume e composição da calda e características do alvo. Assim, o objetivo deste trabalho foi avaliar o espectro de gotas produzidas por pontas de jato plano defletor (TT 11002 e jato plano defletor com indução de ar (TTI 11002, com diferentes adjuvantes adicionados à calda de pulverização, pela técnica de difração de raio laser. O experimento foi conduzido em delineamento inteiramente casualizado, com quatro repetições, em esquema fatorial 2 x 5, ou seja, duas pontas de aplicação (jato plano defletor e jato plano defletor com indução de ar e cinco composições de calda (água e água mais quatro adjuvantes: fosfatidilcoline+ácido propiônico, éter poliglicólico de monilfenol, ésteres de ácidos graxos e nonil-fenol etoxilado+óxido de etileno. Em ambiente controlado, avaliou-se o espectro de gotas, por meio de um analisador a laser de gotas em tempo real, na pressão de 276 kPa. O efeito dos adjuvantes no espectro de gotas mostrou-se dependente da ponta de pulverização empregada. A adição dos adjuvantes à calda não alterou o risco potencial de deriva, expresso pela porcentagem do volume em gotas com diâmetro inferior a 100 µm, porém o adjuvante fosfatidilcoline+ácido propiônico reduziu o diâmetro da mediana volumétrica das gotas produzidas pela ponta de jato plano defletor com indução de ar, em relação à avaliação feita somente com água.The success of an efficient pesticide application depends on the synergy among factors such as droplet size, nozzle type, pressure, spray volume, spray tank mixture and target. The aim of this work was to evaluate the spectrum of droplets produced by turbo flat-fan (TT 11002 and air induction turbo flat-fan (TTI 11002 spray nozzles, with different adjuvants added to the tank mix, using the laser diffraction technique. The

  20. Hydrogen in motor car engineering. Production, storage, use. 3. rev. ed.; Wasserstoff in der Fahrzeugtechnik. Erzeugung, Speicherung, Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Eichlseder, Helmut [Technische Univ., Graz (Austria). Inst. fuer Verbrennungskraftmaschinen und Thermodynamik; Klell, Manfred [HyCentA Research GmbH, Graz (Austria)

    2012-07-01

    The book outlines the various aspects of properties, generation, storage and uses of hydrogen. The focus is on the thermodynamics of hydrogen storage and on its applications in vehicle engineering and energy engineering. Using the example of current research projects of TU Graz university and HyCentA, the state of the art is presented in some detail. The sections on fuel cells for automotive power generation, hydrogen/methane mixtures and legal and safety aspects have been updated. [German] Dieses Buch bietet einen allgemeinen Ueberblick ueber die verschiedenen Aspekte von Eigenschaften, Erzeugung, Speicherung und Anwendung von Wasserstoff. Schwerpunkte liegen auf der Thermodynamik der Speicherung von Wasserstoff sowie auf der Anwendung in der Fahrzeugtechnik und in der Energietechnik. Mit Bezug zu Forschungsvorhaben an der TU Graz und dem HyCentA wird der aktuelle Stand der Technik fundiert dargestellt. Aktualisiert und ergaenzt wurden vor allem die Abschnitte ueber Brennstoffzellen zur Stromerzeugung fuer Elektroantriebe, ueber Gemische aus Wasserstoff und Methan sowie ueber Fragen von Recht und Sicherheit.

  1. The integrity concept and its implementation; Das Integritaetskonzept und seine praktische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Roos, E.; Herter, K.H.; Schuler, X. [Stuttgart Univ. (Germany). MPA; Koenig, G. [EnBW Kernkraft GmbH, Neckarwestheim (Germany)

    2008-07-01

    , dass fuer die Gewaehrleistung von Bruchausschluss die Beherrschung der Ursachen von im Betrieb moeglichen Schaedigungsmechanismen von entscheidender Bedeutung ist. Im Gegensatz dazu stellt das ''Integritaetskonzept'' als Umsetzung des Basissicherheitskonzepts unter Beruecksichtigung der jeweiligen anlagenspezifischen Voraussetzungen ein geschlossenes Gesamtkonzept dar, das der Notwendigkeit einer mehrstufigen Absicherung und ''laufender'' Aktualisierung Rechnung traegt. Das Integritaetskonzept ist Bestandteil des Alterungsmanagements fuer mechanische Komponenten und Systeme. Am Beispiel der Speisewasserleitung innerhalb Containment der Anlage GKN 1 wird dessen praktische Anwendung zum Nachweis der Integritaet aufgezeigt. (orig.)

  2. Adjuvantes nas propriedades físicas da calda, espectro e eficiência de eletrificação das gotas utilizando a pulverização eletrostática

    Directory of Open Access Journals (Sweden)

    Robson Shigueaki Sasaki

    2015-02-01

    Full Text Available Os adjuvantes têm sido empregados na pulverização de agrotóxicos, entretanto, ainda se carece de informações sobre o efeito destes produtos, principalmente quando se emprega o sistema eletrostático. O presente trabalho foi conduzido com o objetivo de avaliar dez soluções de pulverização (nove adjuvantes e uma testemunha, quanto às propriedades físicas (viscosidade e condutividade elétrica e quanto ao espectro e a eficiência de eletrificação da gota na pulverização eletrostática. Utilizou-se um pulverizador eletrostático da marca Electrostatic Spraying Systems e modelo MB 4.0. Para avaliar a viscosidade, a metodologia de Ostwald foi utilizada, enquanto a condutividade elétrica foi determinada com uso de um condutivímetro, marca Marte e modelo MB-11. Na análise da carga elétrica presente na gota, utilizou-se a metodologia da gaiola de Faraday e a avaliação do espectro foi realizada por meio de um analisador de partículas a laser (Spraytech Malvern(r. Os adjuvantes testados alteraram a viscosidade da calda, variando entre 0,94 e 1,03mPa s. Para a condutividade elétrica, observou-se que a água apresentou 67,7µS cm-1 e, com o uso de adjuvantes, o valor obtido foi de até 607,5µS cm-1. Quanto à eletrificação das gotas, houve aumento de até 50,14% na relação Q/M com o uso de adjuvantes, demonstrando que auxiliam na pulverização eletrostática. De forma geral, os adjuvantes reduziram o diâmetro das gotas pulverizadas

  3. Application of the EC pressure equipment directive in the gas industry; Die Anwendung der EG-Druckgeraeterichtlinie in der Gaswirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Bueschel, K. [Deutscher Verein des Gas- und Wasserfaches e.V., Bonn (Germany); John, M. [Karlsruhe Univ. (T.H.) (Germany). DVGW-Forschungsstelle am Engler-Bunte-Institut; Wasser, U. [Bundesverband der Deutschen Gas- und Wasserwirtschaft e.V., Bonn (Germany)

    2000-07-01

    The EC Pressure Equipment Directive primarily concerns that broad range of equipment that falls under the Equipment Safety Act and its regulations on pressure vessels, boilers etc. Meanwhile, however, the mainstream view is that also some equipment of the gas industry is affected although its pipeline systems have been excluded from the Directive. The interpretation of the Directive must take into account this background in order to reach satisfactory conclusions in the actual application of the Directive to the components of the gas industry. (orig.) [German] Die EG-Druckgeraeterichtlinie betrifft primaer jenes grosse Geraetespektrum, das unter das Geraetesicherheitsgesetz und dessen Verordnungen zu Druckbehaeltern, Dampfkesseln etc. faellt. Inzwischen herrscht jedoch die Meinung vor, dass auch bestimmte Anlagenteile der Gaswirtschaft erfasst werden, obwohl deren Rohrleitungssysteme von der Richtlinie ausgenommen worden sind. Die Auslegung der Richtlinie muss diesen Hintergrund beachten, um zu befriedigenden Aussagen bei ihrer konkreten Anwendung auf die Komponenten der Gaswirtschaft zu gelangen. (orig.)

  4. Status reports on the development and application of acoustic emission analysis. Proceedings; Statusberichte zur Entwicklung und Anwendung der Schallemissionsanalyse. Beitraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This proceedings-CD comprises 20 papers presented at the 17. Kolloquium Schallemission (Acoustic Emission Colloquium) at Bad Schandau. The following subjects were discussed: 1. Acoustic emission analysis of tensile tests on standard test specimens of different wood materials; 2. Application of pattern recognition methods for damage analyses of fibre-reinforced plastics; 3. Acoustic emission analysis for measuring crack growth in finned armor steel under dynamic load; 4. Acoustic emission analysis with zonal sound location: Test objects, test results and evaluation of acoustic emission signals; 5. Acoustic emission analysis in overall fatigue testing of a wind rotor blade; 6. Laboratory methods for assessing the sensitivity of acoustic emission sensors; 7. Acoustic emission analysis in burst tests of cast aluminium casings; 8. Visualization of acoustic emission localizations; 9. Threshold-independent and complete recording of characteristics and wave forms of transient and continuous acoustic emission; 10. Characterization of wide-band acoustic emission sensors; 11. Handling of large data volumes in acoustic emission analysis, a contribution to the development of algorithms; 12. Acoustic emission analysis and ultrasonic analysis for the characterization of crack networks in saline rock. One of the papers is available as a separate record in this database. [German] Diese Tagungs-CD enthaelt 20 Vortraege, die auf dem 17. Kolloquium Schallemission in Bad Schandau gehalten wurden. Die Themen waren: 1. Schallemissionsanalyse von Zugversuchen an Standardpruefkoerpern aus unterschiedlichen Holzwerkstoffen; 2. Anwendung von Mustererkennungsverfahren zur Schadensanalyse in faserverstaerkten Kunststoffen; 3. Anwendung der Schallemissionsanalyse zur Ermittlung des Risswachstums bei schwingender Beanspruchung von geripptem Bewehrungsstahl; 4. Schallemissionspruefung mit zonaler Ortung Pruefobjekte, Pruefergebnisse und Nachbewertung von Schallemissionssignalen; 5

  5. Results of radiotherapy for meningeomas with high risk for local recurrence. A retrospective analysis; Ergebnisse der Strahlentherapie bei Meningeomen mit hohem Rezidivrisiko. Eine retrospektive Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, C.; Dornfeld, S.; Friedrich, S.; Baumann, M. [Technische Univ. Dresden (Germany). Klinik und Poliklinik fuerStrahlentherapie und Radioonkologie; Schwarz, R. [Universitaetskrankenhaus Hamburg-Eppendorf (Germany). Abt. fuer Strahlentherapie

    1998-12-01

    Patienten mit Meningeomen bestrahlt. Der Nachbeobachtungszeitrum betrug im Median 61 Monate (Spanne: 0,8 bis 213 Monate). Die Vorstellung zur Strahlentherapie erfolgte entweder beim Tumorrezidiv oder nach Probeexzision, R1- oder R2-Resektion. Das Verhaeltnis maligne (n=20): benigne (n=47) Histologien betrug 1:2,4. Das mediane Alter lag bei 55 Jahren (Spannbreite: Sieben bis 77 Jahre). Die Radiatio wurde mit einer Einzeldosis von 1,5 bis 2 Gy pro Fraktion bis zu einer Gesamtdosis von 36 bis 79,5 Gy durchgefuehrt. Die Ueberlebenskurven wurden nach Kaplan-Meier berechnet. Univariate Vergleiche erfolgten mittels Log-rank-Test, multivariate Analysen mittels Cox-Proportional-Hazards-Model. Um die Haeufigkeit signifikanter Einflussfaktoren nicht zu ueberschaetzen, wurde eine Bonferroni-Korrektur durchgefuehrt. Ergebnisse: Das krankheitsspezifische Ueberleben nach fuenf und zehn Jahren betrug 82%{+-}5% (Standardfehler) bzw. 70%{+-}9% mit einer lokalen Kontrolle von 78%{+-}5% bzw. 68%{+-}9%. Bezueglich Histologie, Geschlecht, Gesamtdosis und Behandlungszentrum wurden keine signifikanten Unterschiede in den uni- und multivariaten Vergleichen gefunden. Signifikant war sowohl fuer die lokale Kontrolle als auch fuer das krankheitsspezifische Ueberleben das Alter (univariat p=0,02/0,04; multivariat p=0,03/0,04). Die postoperative R-Situation hatte einen signifikanten Einfluss auf das krankheitsspezifische Ueberleben (p=0,04). Nach Bonferroni-Korrektur sind diese Signifikanzen nicht mehr nachweisbar. Spaetnebenwirkungen, insbesondere Hirnnekrosen, wurden in unserem Patientengut nicht beobachtet. Schlussfolgerungen: Trotz des negativ selektierten Patientengutes konnten gute Ergebnisse bezueglich lokaler Kontrolle und Ueberleben erreicht werden. Dies unterstuetzt den Stellenwert der Strahlenbehandlung beim Meningeom mit hohem Lokalrezidivrisiko. (orig.)

  6. A new intranasal influenza vaccine based on a novel polycationic lipid-ceramide carbamoyl-spermine (CCS). II. Studies in mice and ferrets and mechanism of adjuvanticity.

    Science.gov (United States)

    Even-Or, Orli; Joseph, Aviva; Itskovitz-Cooper, Noga; Samira, Sarit; Rochlin, Eli; Eliyahu, Hagit; Goldwaser, Itzik; Balasingam, Shobana; Mann, Alex J; Lambkin-Williams, Rob; Kedar, Eli; Barenholz, Yechezkel

    2011-03-16

    We recently showed that lipid assemblies comprised of a novel polycationic sphingolipid (ceramide carbamoyl-spermine, CCS) are an effective adjuvant/carrier when complexed with cholesterol (CCS/C) for influenza and other vaccines administered parenterally and intranasally (i.n.) in mice. Here we expand these studies to ferrets, an established model of influenza infection. We also address the question of why the CCS/C-based liposomal vaccine (also known as VaxiSome™) in mice is superior to vaccines based on liposomes of other lipid compositions (neutral, anionic or cationic). Ferrets immunized i.n. with CCS/C-influenza vaccine produced significantly higher hemagglutination inhibition (HI) antibody titers compared to ferrets immunized intramuscularly with the unadjuvanted influenza vaccine, indicating that the CCS/C-based vaccine is very immunogenic. Furthermore, the i.n. adjuvanted vaccine was shown to significantly reduce the severity of influenza virus infection in ferrets following homologous viral challenge as determined by weight loss, temperature rise and viral titer. No adverse reactions were observed. Pharmacokinetic and biodistribution studies following i.n. administration in mice of CCS/C-based vaccine showed that both the lipids and antigens are retained in the nose and lung for at least 24h, and it appears that this retention correlates with the superior immunogenicity elicited by the adjuvanted vaccine formulation. The CCS lipid also increases production of cytokines (mainly IFN gamma, IL-2 and IL-12) and co-stimulatory molecules' expression, which might further explain the robust adjuvantation of this liposome-based vaccine. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Better compliance with hypofractionation vs. conventional fractionation in adjuvant breast cancer radiotherapy. Results of a single, institutional, retrospective study

    Energy Technology Data Exchange (ETDEWEB)

    Rudat, Volker; Nour, Alaa; Hammoud, Mohamed; Abou Ghaida, Salam [Saad Specialist Hospital, Department of Radiation Oncology, Al Khobar (Saudi Arabia)

    2017-05-15

    The aim of the study was to identify factors significantly associated with the occurrence of unintended treatment interruptions in adjuvant breast cancer radiotherapy. Patients treated with postoperative radiotherapy of the breast or chest wall between March 2014 and August 2016 were evaluated. The radiotherapy regimens and techniques applied were either conventional fractionation (CF; 28 daily fractions of 1.8 Gy or 25 fractions of 2.0 Gy) or hypofractionation (HF; 15 daily fractions of 2.67 Gy) with inverse planned intensity-modulated radiotherapy (IMRT) or three-dimensional planned conformal radiotherapy (3DCRT). Logistic regression analysis was used to identify factors associated with noncompliance. Noncompliance was defined as the missing of at least one scheduled radiotherapy fraction. In all, 19 of 140 (13.6%) patients treated with HF and 39 of 146 (26.7%) treated with CF experienced treatment interruptions. Of 23 factors tested, the fractionation regimen emerged as the only independent significant prognostic factor for noncompliance on multivariate analysis (CF; p = 0.007; odds ratio, 2.3; 95% confidence interval, 1.3-4.2). No statistically significant differences concerning the reasons for treatment interruptions could be detected between patients treated with CF or HF. HF is significantly associated with a better patient compliance with the prescribed radiotherapy schedule compared with CF. The data suggest that this finding is basically related to the shorter overall treatment time of HF. (orig.) [German] Ziel der Untersuchung war es, Faktoren zu identifizieren, die mit ungeplanten Behandlungsunterbrechungen bei der adjuvanten Strahlentherapie des Mammakarzinoms assoziiert sind. Es wurden Patienten untersucht, die eine adjuvante Strahlentherapie der Mamma oder Brustwand zwischen Maerz 2014 und August 2016 erhielten. Zur Anwendung kamen als Fraktionierungsprotokoll und strahlentherapeutische Technik eine konventionell fraktionierte (CF; 28 Fraktionen mit

  8. Gerbstoffe aus Potentilla officinalis wirken entzündungshemmend im UV-Erythem-Test und bei Anwendung auf atopischer Haut.

    Science.gov (United States)

    Hoffmann, Julia; Wölfle, Ute; Schempp, Christoph M; Casetti, Federica

    2016-09-01

    Das Rhizom von Potentilla officinalis (PO) ist reich an Gerbstoffen und wird traditionell zur äußerlichen Behandlung von Entzündungen der Haut und der Schleimhäute verwendet. Ziel der vorliegenden Arbeit war die Bestätigung der antiinflammatorischen Eigenschaften von PO mittels eines UV-Erythem-Tests und einer klinischen Anwendungsstudie bei atopischer Haut. Die antiinflammatorische Wirkung eines PO-Extrakts (standardisiert auf 2 % Trockensubstanz) wurde in einer prospektiven, randomisierten, placebokontrollierten Doppelblindstudie mit 40 gesunden Erwachsenen im UV-Erythem-Test im Vergleich zu 1 % Hydrocortisonacetat untersucht. Im Rahmen einer prospektiven nicht kontrollierten Studie wurde die Wirkung und Verträglichkeit der 2 % PO-Creme an zwölf Erwachsenen und zwölf Kindern mit atopischer Haut nach Anwendung über zwei Wochen in einem definierten Testareal anhand eines Teil-SCORAD untersucht. Zusätzlich wurde die Beeinflussung der Hautrötung im Testareal photometrisch gemessen. Im UV-Erythem-Test zeigte die PO-Creme eine signifikante Reduktion des Erythemindex im Vergleich zum Vehikel. Die antiinflammatorische Wirkung des Verums entsprach der der 1 % Hydrocortisonacetat-Creme. Die klinische Studie bei Atopikern zeigte eine signifikante Abnahme des Teil-SCORAD und des Erythems im Testareal. Es wurden keine Unverträglichkeitsreaktionen beobachtet. PO als 2%ige Zubereitung besitzt entzündungshemmende Eigenschaften und ist wirksam und gut verträglich auf atopischer Haut. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  9. Intravenous administration of iodinated, non-ionic, low or isoosmolar contrast media: safety aspects; Intravenoese Anwendung von jodiertem, nichtionischem, nieder- bis isoosmolarem Kontrastmittel: Sicherheitsaspekte

    Energy Technology Data Exchange (ETDEWEB)

    Metz-Schimmerl, S.; Metz, V.; Schima, W.; Herold, C. [Universitaetsklinik fuer Radiodiagnostik und Ludwig Boltzmann-Institut fuer Klinische und Experimentelle Radiologie, Wien (Austria); Domanovits, H. [Universitaetsklinik fuer Notfallmedizin Wien, Wien (Austria)

    2002-01-01

    It iss the purpose of this review to provide information about the safe use of intravenously administered, iodinated, non-ionic, low or isoosmolar contrast media for radiological examinations, how to avoid adverse events, and how to react professionally in case of an anaphylactic reaction. Methods of prophylaxis and therapy for anaphylactic and chemotoxic effects of contrast media administration as well as absolute and relative contraindications are discussed. Medico-legal considerations of contrast agent administration, informed consent of patients, and methods of risk management for undesired contrast media reactions are considered in this article. Establishment of administration standards for contrast media is of tremendous importance to standardize radiological procedures. This basic radiological documentation is part of the institutional and individual legal safety management. (orig.) [German] Ziel dieses Artikels ist es, Kenntnisse zur sicheren Anwendung von intravenoes applizierten, jodierten, nichtionischen, nieder- bis isoosmolaren Roentgen-Kontrastmitteln zu vermitteln, um bei deren Verwendung unerwuenschte Wirkungen zu vermeiden oder im Falle eines anaphylaktischen Kontrastmittelzwischenfalls rasch und effektiv zu handeln. Neben Methoden der Verhuetung und Behandlung anaphylaktischer und chemotoxischer Wirkungen der Kontrastmittelgabe werden Einschraenkungen der Anwendung bei unterschiedlichen klinischen Bildern eroertert. Rechtliche Ueberlegungen zur Kontrastmittelanwendung, das Aufklaerungsgespraech und Praeventivmassnahmen zum Risiko-Management unerwuenschter Kontrastmittelwirkungen sind beruecksichtigt. Die Festlegung von Anwendungstandards fuer Kontrastmittel dient der Normierung medizinischen Vorgehens. Eine solche radiologische Basisdokumentation ist teil der institutionellen und individuellen rechtlichen Absicherung. (orig.)

  10. Psychometric properties of the stress index radiooncology (SIRO) - a new questionnaire measuring quality of life of cancer patients during radiotherapy; Psychometrische Eigenschaften des Stress Index RadioOnkologie (SIRO) - ein neuer Fragebogen zur Erfassung der Lebensqualitaet bei Patienten unter Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Sehlen, S.; Fahmueller, H.; Lenk, M.; Duehmke, E. [Klinik und Poliklinik fuer Strahlentherapie, Ludwig-Maximilians-Univ., Klinikum Grosshadern, Muenchen (Germany); Herschbach, P. [Inst. und Poliklinik fuer Psychosomatische Medizin, Psychotherapie und Medizinische Psychologie, Technische Univ., Muenchen (Germany); Aydemir, U. [Inst. fuer Biometrie und Epidemiologie, Ludwig-Maximilians-Univ., Klinikum Grosshadern, Muenchen (Germany)

    2003-04-01

    Purpose: In the course of radiotherapy oncological patients often experience considerable psychosocial distress. For its measurement however, no specific questionnaire is available. The stress index radiooncology (SIRO), which is based upon the results of extensive preliminary studies, will be made available as a screening-instrument to facilitate measurement of psychosocial distress of cancer patients, including radiotherapy-induced distress. The aim of this study is, to psychometrically evaluate the preliminary version of the questionnaire, to transfer it to the final version (SIRO) and to gain information about the psychosocial distress of radiooncological patients at the beginning of radiotherapy. Patients and Methods: 104 cancer patients (18 to 85 years) with different diagnoses have been included in the study (Table 1). The data have been assessed by means of the preliminary version of the new questionnaire SIRO, the HADS, EORTC QLQ-C30 and LS. With 25 patients semistructured clinical interviews have been conducted. (orig.) [German] Hintergrund: Die strahlentherapeutische Behandlung von Tumorpatienten ist haeufig mit starken psychosozialen Belastungen verbunden, fuer deren Erfassung es bisher keinen spezifischen Fragebogen gibt. Mit dem stress index radioonkologie (SIRO), der auf den Analyseergebnissen umfangreicher Voruntersuchungen beruht, soll erstmals ein Screening-Instrument zur Verfuegung gestellt werden, mit dem die psychosozialen Belastungen von Tumorpatienten, einschliesslich der durch Strahlentherapie induzierten, erfasst werden koennen. Ziel dieser Studie ist, die Fragebogen-Vorform psychometrisch zu evaluieren und in die endgueltige Fragebogenversion (SIRO) zu ueberfuehren. Darueber hinaus sollen Informationen ueber das psychosoziale Belastungsprofil radioonkologischer Patienten zu Beginn einer Strahlentherapie gewonnen werden. Patienten und Methoden: 104 Tumorpatienten (18-85 Jahre) mit unterschiedlichen Diagnosen wurden in die Studie aufgenommen

  11. Adjuvant treatment of gastric cancer in a long term follow-up Tratamento adjuvante no câncer gástrico em seguimento a longo prazo

    Directory of Open Access Journals (Sweden)

    Miriam Honda Federico

    2009-03-01

    was predominantly gastrointestinal (63, neurological (2, hematological (3, stroke (1. Toxicity was considered GI/GII (52, GIII (10 and GIV (1. Recurrences were local (6; loco-regional (2; local and distant (5; regional (9; regional and distant (2 and only distant (4. There were two patients with progression of the disease and 11 were lost of the follow-up (16%. Twenty eight (40,5% were alive without disease. In the 52 patients with longer follow-up the Kaplan Mayer analysis showed: better overall survival was observed in those patients presenting T2 versus T3/T4 tumors (not reached vs 17,3 mo, HR 0,35, 95%CI , P=0,03, N0N1 vs N2/N3 tumors (32,7 mo vs 14,5 mo, P=0,0041 and free vs compromised surgical margins (25,7 vs 17,2 mo, P=0,03. No difference in either T (P=0,430, Fisher exact test, N-stage (P= 0,077, or overall survival (27,1 mo vs 17,3 mo, P=0,28 were detected between patients submitted to D1 or D2 dissections. CONCLUSIONS: In this high-risk population of gastric cancer submitted to adjuvant chemoradiation, D2 dissection was not superior to D1 when chemoradiation was administered, in spite of the retrospective nature of these data and the low number of studied patients. Patients with compromised surgical margins have a very poor prognosis and the addition of chemoradiation seems not improve the survival of these patients.RACIONAL: Câncer gástrico avançado é sempre acompanhado de pobre prognóstico. A melhor forma de ser realizada a linfadenectomia e o valor da radioquimioterapia adjuvante ainda estão em tela de juízo. OBJETIVO: Estudar a eficácia da terapia adjuvante e o valor prognóstico de algumas variáveis clínico-patológicas nos pacientes submetidos à ressecção cirúrgica de seus tumores. MÉTODOS: Estudo retrospectivo de uma única instituição hospitalar incluindo 69 pacientes com diagnóstico histológico de adenocarcinoma gástrico consecutivamente submetidos à operação radical com intenção curativa no período de cinco anos

  12. Resposta sorológica de coelhos imunizados com antígenos de Pythium insidiosum associados a diferentes adjuvantes Serological response in rabbits immunized with Pythium insidiosum antigens associated with different adjuvants

    Directory of Open Access Journals (Sweden)

    Alexandre Trindade Leal

    2002-12-01

    Full Text Available O Pythium insidiosum é um fungo zoospórico que se desenvolve em locais alagadiços e que pode infectar humanos e animais, principalmente eqüinos. A infecção natural nesta espécie resulta em pitiose clínica, uma doença granulomatosa de difícil tratamento. Uma das opções terapêuticas é a imunoterapia com antígenos obtidos de culturas do agente. Com o objetivo de avaliar o efeito de adjuvantes na resposta sorológica a antígenos do P. insidiosum, 24 coelhos divididos em 4 grupos foram imunizados com antígeno macerado de micélio (AMM associado a três adjuvantes. Grupo I: hidróxido de alumínio; grupo II: adjuvante de Freund; grupo III: óleo mineral e grupo IV: água destilada -controle. Os tratamentos foram avaliados a diferentes intervalos, quanto à capacidade de induzir a produção de imunoglobulinas específicas da classe G, através da técnica de ELISA. Na fase 1, os animais receberam três doses do imunógeno (dias zero, 14 e 28 e foram avaliados sorologicamente nos dias 14, 21, 28 e 35. Nessa fase, os adjuvantes oleosos (GII e III induziram níveis de anticorpos estatisticamente superiores aos induzidos nos grupos I e IV. Durante a fase 2 (dias 42 a 120, cada grupo foi subdividido em dois; sendo um subgrupo mantido em tratamento (imunizações adicionais nos dias 42, 56, 68 e 82 e o outro tendo o tratamento interrompido após a 3ª dose (dia 28. Nos subgrupos mantidos em tratamento, os níveis de anticorpos dos grupos imunizados com adjuvantes foram estatisticamente superiores aos induzidos no grupo GIV (controle. Nos coelhos com tratamento interrompido, os grupos I, II e III apresentaram manutenção nos níveis de IgG e foram estatisticamente superiores ao grupo controle, que apresentou declínio nos níveis de anticorpos. Os resultados demonstraram a capacidade dos adjuvantes testados em potencializar e prolongar a resposta humoral aos antígenos do P. insidiosum. O uso de adjuvantes associado aos atuais imun

  13. Adjuvantes e herbicidas e a infectividade de Fusarium graminearum, agente potencial de biocontrole de Egeria densa e Egeria najas Adjuvants and herbicides and the infectivity of Fusarium graminearum, a potential biocontrol agent of Egeria densa and Egeria najas

    Directory of Open Access Journals (Sweden)

    C.R. Borges Neto

    2004-03-01

    Full Text Available Foram estudados os efeitos da adição de adjuvantes e a associação com herbicidas na infectividade do fungo dentro do patossistema Fusarium graminearum x Egeria spp. Foram utilizadas plantas sadias de Egeria densa e E. najas inoculadas com uma suspensão de arroz moído colonizado por F. graminearum, na concentração de 0,7 g L-1. Os tubos de ensaio contendo as plantas imersas na referida suspensão foram mantidos em incubadora à temperatura de 25 ºC e fotoperíodo de 12 horas diárias de luz, por oito dias, durante os quais foram avaliados os sintomas nas plantas a cada dois dias e o crescimento destas através do incremento de matéria fresca ao final do experimento. O efeito de 14 adjuvantes e 6 herbicidas, adicionados à suspensão de inóculo, sobre a ação de F. graminearum em E. densa e E. najas foi avaliado. De modo geral, os adjuvantes melhoraram a eficiência do bioerbicida e a associação herbicida + fungo proporcionou maior severidade de doença e controle do crescimento das plantas.The effects of adding adjuvants and their association with herbicides on fungus infectivity were studied in the Fusarium graminearum x Egeria spp. pathosystem. Healthy Egeria densa and E. naja plants were inoculated with suspension of ground rice with F. graminearum, at a concentration of 0.7 g L-1. The assay tubes with the plants immersed in the suspension were kept in the incubator at the temperature of 25 ºC and photoperiod of 12 hours daily, with plant symptoms being evaluated every two hours and plant growth monitored based on fresh matter increase at the end of the experiment. The effect of 14 adjuvants and 6 herbicides added to the inoculum on the action of F. graminearum against E. densa and E. najas was evaluated. In general, the adjuvants improved bioherbicide efficiency and the herbicide + fungus association increased disease severity and plant growth control.

  14. Disease specific stress of tumor patients at the beginning of radiotherapy. Effect on psychosocial support requirement; Krankheitsspezifische Belastungen von Tumorpatienten zu Beginn einer Strahlentherapie. Auswirkungen auf den psychosozialen Betreuungsbedarf

    Energy Technology Data Exchange (ETDEWEB)

    Sehlen, S.; Hollenhorst, H.; Schymura, B.; Firsching, M.; Duehmke, E. [Ludwig-Maximilians-Univ., Muenchen (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Aydemir, U. [Inst. fuer Biometrie und Epidemiologie, Klinikum Grosshadern, Ludwig-Maximilians-Univ., Muenchen (Germany); Herschbach, P. [Technische Univ. Muenchen (Germany). Inst. und Poliklinik fuer Psychosomatische Medizin, Psychotherapie und medizinische Psychologie

    2001-10-01

    requirement. (orig.) [German] Hintergrund: Die Radiotherapie bringt Tumorpatienten in eine besondere Lebenssituation, in der sie eine Reihe von unterschiedlichen Faktoren ausgesetzt werden, deren Auspraegung weitgehend unbekannt ist. Intention dieser Querschnittsstudie war es, erstmals systematisch die spezifischen Belastungen von Tumorpatienten zu Beginn einer Strahlentherapie aufzuzeigen und einen belastungsabhaengigen Betreuungswunsch zu erheben mit dem Ziel einer Belastungsreduktion und Verbesserung von Lebensqualitaet und Compliance waehrend einer radioonkologischen Behandlung. Patienten und Methoden: 732 Patienten wurden zunaechst in die Studie aufgenommen, von denen 446 (60,9%) die Einschlusskriterien erfuellten (Ablehnung 21,0%, Karnofsky-Index 6,6%, organisatorische Probleme 3,4%, Sprachbarrieren 3,0%, kognitive Einschraenkung 2,6%, Tod 2,5%). Folgende Erhebungsinstrumente gingen in die Auswertung zu Beginn der Strahlentherapie ein: medizinische und soziodemographische Daten, Lebenssituation (LS), Fragebogen zur Belastung von Krebspatienten (FBK), selbst definierter Betreuungswunsch (BB). 262 Maenner und 184 Frauen (medianes Alter 60,0 Jahre) mit unterschiedlichen Diagnosen wurden untersucht. Ergebnisse: Auf Skalenebene des Fragebogens zur Belastung von Krebspatienten zeigte sich vor allem eine Belastung durch Einschraenkung der Leistungsfaehigkeit, Angst und Schmerz. Frauen hatten signifikant hoehere Belastungswerte in den Bereichen Schmerz (p=0,016) und Angst (p=0,009), Patienten unter 45 Jahren im Bereich Information (p=0,002) und Patienten zwischen 45 und 60 Jahren in den Bereichen Angst (p=0,002) und Gesamtbelastung (p=0,003). Patientinnen mit einem Mammakarzinom waren am staerksten belastet. Der Anteil von stark belasteten Patienten war in den Skalen Leistungsfaehigkeit (43%) und Angst (40%) am hoechsten. Es bestand ein signifikanter Zusammenhang zwischen hoher Belastung und hohem Betreuungswunsch (insbesondere nach Arzt-/Psychologengespraechen und Information

  15. Influence of spray nozzles and adjuvants in drift reduction potential in wind tunnel Influência de pontas de pulverização e adjuvantes no potencial de redução de deriva em túnel de vento

    Directory of Open Access Journals (Sweden)

    Rodolfo Glauber Chechetto

    2013-03-01

    Full Text Available The drift is intimately linked to inappropriate use of pesticides and an important factor for reducing it, is the correct selection of spray nozzles and adjuvants. The objective of this work was to evaluate the drift potential in wind tunnel with different spray nozzles and different concentrations of adjuvants. The experiment was composed by six spray solutions (vegetable oil (in three concentrations, mineral oil, surfactant and reducing drift, which were applied with two nozzles, one pre-orifice flat fan (DG 8003 VS and other with air induction (AI 8003 VS, totaling 12 treatments, with three repetitions. The equipment used was a wind tunnel, where the drift collections were made at different points. The treatments averages were compared using Confidence Interval at 5% probability. The analysis of the percentage of drift showed that the treatments had different behaviors. The nonylphenol ethoxylate adjuvant presented the highest drift when applied with the nozzle of pre-orifice and the lowest drift when applied with the air induction. The behavior of these nozzles when the oil-based adjuvant was used showed apposite results to those obtained for the surfactant. For the DG nozzles the lowest percentage of drift, at all analyzed distances, was observed to the treatment with vegetable oil (1.0% and with the AI nozzles the lower drift was found for the treatment with nonylphenol ethoxylate (0.0625%, for the four distances in the collection. The result showed that both the spray nozzles and adjuvants alter directly the drift potential. There was no proportionately between the concentration of the oil-based adjuvant and the drift percentage.A deriva está diretamente ligada ao uso inadequado da tecnologia de aplicação de agrotóxicos, sendo a correta seleção das pontas de pulverização e adjuvantes importantes variáveis para auxiliar em sua redução. O objetivo deste trabalho foi estimar o potencial de deriva em túnel de vento com diferentes

  16. Tensão superficial estática de misturas em tanque de glyphosate + chlorimuron-ethyl isoladas ou associadas com adjuvantes Static superficial tension of glyphosate and chlorimuron-ethyl tank mixtures with or without adjuvants

    Directory of Open Access Journals (Sweden)

    C.D.G. Maciel

    2010-01-01

    Full Text Available Objetivou-se neste estudo avaliar a tensão superficial estática, o pH e a produção da espuma de misturas em tanque de glyphosate + chlorimuron-ethyl, associadas ou não com adjuvantes. Dois trabalhos foram realizados, sendo a primeira etapa desenvolvida em delineamento inteiramente casualizado com seis tratamentos e 20 repetições, representados por soluções dos herbicidas glyphosate (540,0 g e.a. ha-1 e chlorimuron-ethyl (7,5 g ha-1, isolados e em mistura em tanque nas formulações: Polaris®; Roundup Ready®; Classic®; Polaris® + Classic®; Roundup Ready® + Classic® e testemunha (água. Na segunda etapa foram estudados em DIC 70 tratamentos e 20 repetições, em fatorial 2 x 5 x 7, constituído por duas misturas de glyphosate com chlorimuron-ethyl (Polaris® + Classic® e Roundup Ready ® + Classic®, cinco adjuvantes (Joint Oil®; Nimbus®; Assist®; Natur' Oil® e Agr' Óleo® e sete doses dos adjuvantes (0,000; 0,031; 0,062; 0,125; 0,250; 0,500 e 1,000% de v/v. As soluções de Polaris® e Roundup Ready®; isoladas ou em misturas com Classic®; caracterizaram-se por tensões superficiais estáticas de 43,2 e 35,9 mN m-1 e pH médios em torno de 4,5 a 4,6, respectivamente. As misturas de Polaris®+Classic®; Roundup Ready®+Classic® e Classic® apresentaram a maior quantidade e persistência da espuma ao longo do tempo, quando comparadas às formulações de Polaris® e Roundup Ready®. Os adjuvantes promoveram redução da tensão superficial quando associados às misturas de Polaris® + Classic® e Roundup Ready® + Classic®; caracterizando-se em termos de eficiência pela ordem decrescente: Nimbus® (36,5% e 25,8% This work aimed to evaluate static superficial tension, pH and foam production in glyphosate + chlorimuron-ethyl tank mixtures with or without adjuvants. The experiment consisted of two stages, with the first stage being arranged in a complete randomized design, with six treatments and 20 replications, represented

  17. A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine.

    Science.gov (United States)

    Verheul, Rolf J; Hagenaars, Niels; van Es, Thomas; van Gaal, Ethlinn V B; de Jong, Pascal H J L F; Bruijns, Sven; Mastrobattista, Enrico; Slütter, Bram; Que, Ivo; Heldens, Jacco G M; van den Bosch, Han; Glansbeek, Harrie L; Hennink, Wim E; Jiskoot, Wim

    2012-03-12

    Recently we reported that reacetylation of N,N,N-trimethyl chitosan (TMC) reduced the adjuvant effect of TMC in mice after intranasal (i.n.) administration of whole inactivated influenza virus (WIV) vaccine. The aim of the present study was to elucidate the mechanism of this lack of adjuvanticity. Reacetylated TMC (TMC-RA, degree of acetylation 54%) was compared with TMC (degree of acetylation 17%) at six potentially critical steps in the induction of an immune response after i.n. administration in mice. TMC-RA was degraded in a nasal wash to a slightly larger extent than TMC. The local i.n. distribution and nasal clearance of WIV were similar for both TMC types. Fluorescently labeled WIV was taken up more efficiently by Calu-3 cells when formulated with TMC-RA compared to TMC and both TMCs significantly reduced transport of WIV over a Calu-3 monolayer. Murine bone-marrow derived dendritic cell activation was similar for plain WIV, and WIV formulated with TMC-RA or TMC. The inferior adjuvant effect in mice of TMC-RA over that of TMC might be caused by a slightly lower stability of TMC-RA-WIV in the nasal cavity, rather than by any of the other factors studied in this paper. Copyright © 2011 Elsevier B.V. All rights reserved.

  18. Low-dose oral tolerance due to antigen in the diet suppresses differentially the cholera toxin-adjuvantized IgE, IgA and IgG response

    DEFF Research Database (Denmark)

    Christensen, Hanne Risager; Kjær, Tanja; Frøkiær, Hanne

    2003-01-01

    Background: Cholera toxin (CT) is used as a mucosal adjuvant amongst other applications for studying food allergy because oral administration of antigen with CT induces an antigen-specific type 2 response, including IgE and IgA production. Priorly established oral tolerance due to antigen...... soy-trypsin inhibitor (KSTI) (F0 mice) and mice fed a soy-free diet (F2 mice) were orally immunized with KSTI and CT. KSTI-specific serum IgG1, IgG2a, IgA and IgE and fecal IgA were monitored. KSTI-stimulated cell proliferation and interleukin (IL)-6 production were determined. Results: The anti...... immunizations. However, cell proliferation and IL-6 production were clearly suppressed even after five immunizations. Conclusions: Priorly established low-dose oral tolerance considerably suppressed the CT-adjuvantized KSTI-specific IgE, IgA and cellular immune response but only weakly and transiently the Ig...

  19. Radiotherapy. Radiological oncology. Strahlentherapie. Radiologische Onkologie

    Energy Technology Data Exchange (ETDEWEB)

    Scherer, E [ed.; Essen Univ. (Gesamthochschule) (Germany, F.R.). Radiologisches Zentrum

    1976-01-01

    This book attempts to give a survey of the present status of radiological tumour therapy with some emphasis on the clinical aspect of neoplasms. The physical and radiobiological fundamentals important for practical radiotherapy are discussed in great detail.

  20. Qualidade de vida de pacientes com câncer de mama em terapia adjuvante Calidad de vida de pacientes con cáncer de mama en terapia adyuvante Quality of life of breast cancer patients in adjuvant therapy

    Directory of Open Access Journals (Sweden)

    Adriana Cristina Nicolussi

    2011-12-01

    Full Text Available O objetivo do estudo foi avaliar a Qualidade de Vida (QV, identificar os domínios afetados em pacientes com câncer de mama em terapia adjuvante e correlacioná-los com características sócio-demográficas, clínicas e terapêuticas. Estudo transversal, realizado com 35 pacientes entre agosto de 2007 e dezembro de 2008. Utilizou-se o instrumento Quality of Life Core-30-Questionnaire (QLQ-C30. A Qualidade de Vida geral foi considerada pouco satisfatória. Os domínios afetados foram: função emocional, insônia, dor e fadiga. Nas correlações, as pacientes acima de 60 anos apresentaram pior escore na função emocional, as submetidas à cirurgia referiram mais constipação, as que realizavam radioterapia obtiveram pior escore para QV geral e as que estavam em quimioterapia há mais de seis ciclos apresentaram a função emocional afetada e dispnéia. Concluiu-se que os tratamentos adjuvantes afetaram de algum modo as pacientes, causando déficit na função emocional e relataram mais sintomas, prejudicando assim sua QV.El objetivo fue evaluar la calidad de vida (CV, identificar los dominios afectados en pacientes con cáncer de mama en terapia adyuvante y correlacionarlos con las características socio-demográficas, clínicas y terapéuticas. Estudio transversal, con 35 pacientes, realizado entre agosto de 2007 y diciembre de 2008. Fue utilizado el instrumento Quality of Life Core-30-Questionnaire (QLQ-C30. La calidad de vida fue considerada poco satisfactoria. Los dominios más afectados fueron: función emocional, insomnio, dolor, fatiga. En las correlaciones, las pacientes con más de 60 años presentaron peores promedios en la función emocional, las pacientes que fueron sometidas a la cirugía refirieron más estreñimiento, las que recibían radioterapia presentaron peores promedios en CV general y las que habían recibido más de seis ciclos de quimioterapia presentaron la función emocional afectada y la disnea. Se concluyó que los

  1. Estudo de custo-efetividade do anastrozol adjuvante no câncer de mama em mulheres pós-menopausa Cost-effectiveness analysis of adjuvant anastrozol in post-menopausal women with breast cancer

    Directory of Open Access Journals (Sweden)

    Andre Deeke Sasse

    2009-01-01

    Full Text Available OBJETIVOS: Análise econômica com dados nacionais sobre a possível incorporação do anastrozol como terapia adjuvante hormonal no câncer de mama em pacientes pós-menopausa. MÉTODOS: Foi feita estimativa de custo-efetividade no tratamento adjuvante do câncer de mama, em mulheres pós-menopausa, do anastrozol versus tamoxifeno em três perspectivas: do paciente, de planos de saúde e do governo. Modelo de Markov foi desenvolvido utilizando dados extraídos de publicação do estudo ATAC após seguimento de 100 meses, com projeção de desfechos em 25 anos para uma coorte hipotética de 1000 pacientes com câncer de mama pós-menopausa no Brasil. Dados de utilização de recursos e custos associados foram obtidos de fontes preestabelecidas e de opinião de especialistas. O custo associado aos tratamentos foi extraído separadamente, dependendo do ponto de vista estudado. O benefício foi inserido no modelo para obtenção do custo por ano de vida ganho ajustado pela qualidade (QALY. RESULTADOS: Extrapolando benefícios encontrados para 25 anos de seguimento, o anastrozol, em relação ao tamoxifeno, resultou numa estimativa de ganho de 0,29 QALY. A razão de custo-efetividade por QALY ganho dependeu da perspectiva utilizada. Houve incremento de R$ 32.403,00/QALY no ponto de vista do SUS; de R$ 32.230,00/QALY no dos planos de saúde; e de R$ 55.270,00/QALY no das pacientes. CONCLUSÃO: O benefício encontrado no uso do anastrozol adjuvante em pacientes com câncer de mama operado na pós-menopausa está associado a grandes diferenças na razão de custo-efetividade, dependendo da perspectiva utilizada para o cálculo. Comparando com parâmetros usualmente aceitos pela OMS, o incremento é aceitável sob a perspectiva do SUS e dos planos de saúde, mas não sob a ótica do paciente.OBJECTIVES: Carry out an economic analysis of the incorporation of anastrozole as adjuvant hormone therapy in postmenopausal women with breast cancer in a Brazilian

  2. Cytoprotection with amifostine in radiotherapy or combined radio-chemotherapy of head and neck cancer; Zytoprotektion mit Amifostin in der Strahlentherapie bzw. Strahlen-/Chemotherapie von Kopf-Hals-Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Altmann, S.; Hoffmanns, H. [Krankenhaus Maria-Hilf, Moenchengladbach (Germany). Strahlentherapie und Radiologische Onkologie

    1999-11-01

    Background: A considerable amount of experimental and clinical data prove the cytoprotective effect of amifostine on normal tissue exposed to different types of antineoplastic treatments. The present study examines its influence on the short-term toxicity of either radiotherapy alone or combined radio-chemotherapy in patients with advanced head and neck cancer. Patients and methods: Twenty-three patients with advanced head and neck cancer, mainly Stage III and IV, were treated with preoperative radiation (n=1), pre- as well as postoperative radiotherapy (n=5), postoperative radiation (n=9) or combined postoperative radio-chemotherapy (n=6). Before each radiation application a total dose of 500 mg amifostine was administered intravenously over 15 minutes. The documentation of this unselected patient group was compared retrospectively to a historical control group comprising 17 patients. Results: In 15 patients (65%) of the amifostine group, therapy induced side effects such as mucositis and dermatitis of WHO Grade {<=}2 were detected, requiring interruptions of the radiotherapy (mean: 6.5, maximum 17 days). No mucosa or dermatologic toxicity of WHO Grade 3 or 4 was observed in this group. Significantly more acute toxicity was detected in the historical control group. Stomatitis or epitheliolysis of WHO Grade 3 occurred in 7 patients (41%). The side effects induced by the antineoplastic therapy caused an interruption of treatment in 15 patients (88%) (mean: 16, maximum 40 days; p=0.0016). Conclusion: The application of amifostine before each radiation treatment seems to result in a distinct reduction of short-term toxicity of radiotherapy or combined radio-chemotherapy in patients with head and neck cancer, allowing for a better adherence to the planned radiation time schedule. (orig.) [German] Hintergrund: Zahlreiche experimentelle und klinische Daten belegen die zytoprotektive Wirkung von Amifostin auf gesundes Gewebe bei Anwendung verschiedener antineoplastischer

  3. PEM-fuel cells for mobile application. Sub task: development of electrocatalysts. Final report; PEM-Brennstoffzelle fuer mobile Anwendung. Teilprojekt: Katalysatorenentwicklung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Starz, K A

    1999-01-01

    PEM fuel cells are gaining increasing importance for use in automotive application. The goal of the research program reported here was to develop the basic technology and components for PEMFC stacks for use in transport applications. The sub-task of Degussa was to develop improved electrocatalysts for PEMFC single cells and stacks. The technical objectives of the research project were met. Electrocatalysts, characterized by a high Pt-dispersion, high surface area and excellent activity, were developed. With this material, considerable progress was made to reduce the total platinum loading of PEMFC cells and stacks to about 0,5 mgPt/cm{sup 2}. With this value, the goal of the program (<0,8 mg/cm{sup 2}) was significantly surpassed. Additionally, higher power densities of >0.4 W/cm{sup 2} were achieved at Degussa for hydrogen/air and reformate/air operation of the PEMFC. A CO-tolerant anode electrocatalyst, exhibiting a CO-tolerance of up to 100 ppm CO, enables the operation of PEMFC stacks with on-board generated methanol reformate. The performance of the new electrocatalyst materials was verified by DaimlerChrysler in a PEMFC demonstration stack at the end of the program. (orig.) [Deutsch] PEM-Brennstoffzellen gewinnen fuer die mobile Anwendung immer mehr an Bedeutung. Im Rahmen des hier beschriebenen Leitprojektes sollten die Basistechnologien fuer den Einsatz der PEM-Brennstoffzelle im mobilen Bereich (Elektrotraktion) entwickelt werden. Das Teilprojekt der Degussa befasst sich mit der Entwicklung von verbesserten Elektrokatalysatoren fuer PEM-Brennstoffzellenstacks. Die technischen Arbeitsziele des Vorhabens wurden erreicht. So konnten Elektrokatalysatoren bereitgestellt werden, die sich durch eine hohe Pt-Dispersion, eine grosse Pt-Oberflaeche sowie eine sehr gute Aktivitaet auszeichnen. Mit diesen Elektrokatalysatoren gelang es, die Platinbeladung der PEM-Elektroden (Anode und Kathode) erheblich abzusenken. Mit einer Gesamtplatinbeladung von 0,5 mg/cm{sup 2

  4. Efeitos de um minuto e dez minutos de deambulação em ratos com artrite induzida por adjuvante completo de Freund sobre os sintomas de dor e edema

    Directory of Open Access Journals (Sweden)

    Raquel Pinheiro Gomes

    2014-04-01

    Full Text Available Este estudo avaliou o efeito de dois protocolos de exercício na nocicepção, edema e migração celular em ratos com artrite induzida por CFA. Ratos Wistar fêmeas (200 - 250 g, n = 50 foram induzidos à monoartrite por adjuvante completo de Freund (CFA, Mycobacterium butyricum; 0,5 mg/mL; 50 μL na articulação do joelho direito (TF; n = 24 ou tornozelo direito (TT; n = 26. A incapacitação articular foi mensurada pelo tempo de elevação da pata (TEP; s em 1 minuto de avaliação. O edema do joelho ou tornozelo foi avaliado pela medida do diâmetro articular (AD, cm e pelo edema de pata (EP, mL, respectivamente. Ambos foram avaliados durante 10 dias consecutivos. Dois protocolos de exercício foram realizados: (a exercício constante (TF, n = 6; TT, n = 6, realizando 1 minuto diário de exercício no cilindro (3 r.p.m.; (b exercício variável (TF, n = 6; TT, n = 7, exercício com aumento de 1 minuto por dia, totalizando 10 minutos no último dia. Os grupos-controle (TF, n = 12; TT, n = 13 não realizaram exercício. Após 10 dias, os animais foram eutanasiados para contagem total (células/mm3 e diferencial (mononucleares e polimorfos nucleares; células/mm3 de leucócitos do tecido inflamado. O exercício variável inibiu a incapacitação e o edema em ambas as articulações. Entretanto, reduziu a migração total de leucócitos apenas na articulação TF. O exercício constante inibiu o edema nas duas articulações e reduziu a migração total de leucócitos da articulação TT. Porém, não reduziu a incapacitação. O exercício variável pareceu ser mais efetivo em reduzir os parâmetros inflamatórios em comparação com o exercício constante.

  5. Potential clinical predictors of outcome after postoperative radiotherapy of non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Buetof, R. [Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Department of Radiation Oncology, Dresden (Germany); Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitaet Dresden, OncoRay National Center for Radiation Research in Oncology, Dresden (Germany); Kirchner, K.; Appold, S. [Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Department of Radiation Oncology, Dresden (Germany); Loeck, S. [Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitaet Dresden, OncoRay National Center for Radiation Research in Oncology, Dresden (Germany); Rolle, A. [Lungenfachklinik Coswig, Department of Thoracic and Vascular Surgery, Coswig (Germany); Hoeffken, G. [Lungenfachklinik Coswig, Department of Pneumology, Coswig (Germany); Krause, M.; Baumann, M. [Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitaet Dresden, Department of Radiation Oncology, Dresden (Germany); Medical Faculty and University Hospital Carl Gustav Carus, Technische Universitaet Dresden, OncoRay National Center for Radiation Research in Oncology, Dresden (Germany); German Cancer Consortium (DKTK), Dresden (Germany); German Cancer Research Center (DKFZ), Heidelberg (Germany); Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany)

    2014-03-15

    The aim of this analysis was to investigate the impact of tumour-, treatment- and patient-related cofactors on local control and survival after postoperative adjuvant radiotherapy in patients with non-small cell lung cancer (NSCLC), with special focus on waiting and overall treatment times. For 100 NSCLC patients who had received postoperative radiotherapy, overall, relapse-free and metastases-free survival was retrospectively analysed using Kaplan-Meier methods. The impact of tumour-, treatment- and patient-related cofactors on treatment outcome was evaluated in uni- and multivariate Cox regression analysis. No statistically significant difference between the survival curves of the groups with a short versus a long time interval between surgery and radiotherapy could be shown in uni- or multivariate analysis. Multivariate analysis revealed a significant decrease in overall survival times for patients with prolonged overall radiotherapy treatment times exceeding 42 days (16 vs. 36 months) and for patients with radiation-induced pneumonitis (8 vs. 29 months). Radiation-induced pneumonitis and prolonged radiation treatment times significantly reduced overall survival after adjuvant radiotherapy in NSCLC patients. The negative impact of a longer radiotherapy treatment time could be shown for the first time in an adjuvant setting. The hypothesis of a negative impact of longer waiting times prior to commencement of adjuvant radiotherapy could not be confirmed. (orig.) [German] Das Ziel der vorliegenden Analyse war, den Einfluss von tumor-, patienten- und therapieabhaengigen Kofaktoren auf die lokoregionale Tumorkontrolle und das Ueberleben nach postoperativer adjuvanter Strahlentherapie bei Patienten mit einem nicht-kleinzelligen Bronchialkarzinom (NSCLC) zu untersuchen. Ein spezieller Fokus lag dabei auf der Wartezeit zwischen Operation und Beginn der Strahlentherapie sowie der Gesamtbehandlungszeit der Strahlentherapie. Fuer 100 Patienten, die eine postoperative

  6. MR implant labelling and its use in clinical MRI practice; MR-Implantatkennzeichnungen und ihre Anwendung in der klinischen MRT-Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Muehlenweg, M. [Krankenhaus Martha-Maria Halle-Doelau, Institut fuer Radiologie, Halle (Saale) (Germany); Schaefers, G. [MR:comp GmbH, Gelsenkirchen (Germany)

    2015-08-15

    Messungen von Patienten mit Implantaten. In juengerer Vergangenheit ist jedoch ein Weg geschaffen worden, diese Kontraindikation legal zu umgehen. Hierfuer sind spezielle Voraussetzungen noetig: Eindeutige Implantatidentifikation und Vorlage der originalen Herstellerkennzeichnung, Gewaehrleistung der geforderten Bedingungen bei ''bedingt MR-sicheren'' Implantaten und Restrisiko-Nutzen-Analyse mit entsprechender Aufklaerung. Dieser Prozess ist u. U. sehr aufwendig, da die Implantate haeufig schlecht dokumentiert und die Detailinformationen der Implantatkennzeichnung ebenfalls nicht selten veraltet oder nicht einfach zu interpretieren sind. Diese Arbeit informiert ueber rechtliche und normative Grundlagen der Messung von Patienten mit Implantaten. Es werden kurz moegliche physikalische Wechselwirkungen mit Implantaten angerissen, moegliche Strategien zur besseren Identifikation und Recherche von Implantaten und ihrer MR-Kennzeichnung aufgezeigt und allgemeine Ansaetze zur Risikominimierung an Beispielen diskutiert. Der zweite Teil geht auf die Inhalte von MR-Implantatkennzeichnungen ein und zeigt die aktuellen Pruefstandards auf. Es werden die fuer die Interpretation von MR-Implantatkennzeichnungen notwendigen Zusatzinformationen aus den Betriebsanleitungen der MR-Scanner erlaeutert. Abschliessend folgen die Erklaerung der aktuellen Muster-MR-Kennzeichnung von Implantaten der FDA (US Food and Drug Administration) und eine exemplarische Anwendung. (orig.)

  7. Handbuch Stahl Auswahl, Verarbeitung, Anwendung

    CERN Document Server

    Bleck, Wolfgang

    2018-01-01

    Stahl ist der wichtigste Konstruktionswerkstoff. Im Maschinen- und Anlagenbau, Fahrzeugbau, Schiffbau, Stahlbau und in vielen anderen Industriebereichen ist er durch keinen anderen Werkstoff zu ersetzen. Für jeden Anwendungszweck gibt es passende Stahlsorten am Markt zu kaufen. Die Feinabstimmung der gewünschten Eigenschaften kann im weiteren Verarbeitungsprozess vorgenommen werden, bis der Werkstoff optimal den gewünschten Produktanforderungen entspricht. Die Anzahl der Möglichkeiten ist sehr groß und somit auch die Schwierigkeit, den genau passenden Stahl zu finden bzw. zu erzeugen. Das vorliegende Handbuch hilft Ihnen, dieses Problem zu lösen. Es zeigt u.a. - mit welchen systematischen Ansätzen und Hilfsmitteln Sie die in Frage kommende Stahlsorte eingrenzen können - die wichtigsten produktrelevanten Eigenschaften und Lieferformen - die werkstoffgerechte Weiterverarbeitung durch umformende und spanende Fertigungsprozesse und Wärmebehandlung - hunderte Anwendungsbeispiele aus Maschinen- und Anlage...

  8. Does the risk of plexus brachialis lesion following therapeutic irradiation of the supraclavicular lymph vessels in breast cancer patients persist life-long?; Besteht das Risiko einer radiogenen Plexus brachialis-Laesion nach Strahlentherapie (RT) der supraklavikulaeren Lymphabflusswege bei Brustkrebs-Patientinnen lebeslang?

    Energy Technology Data Exchange (ETDEWEB)

    Rades, D; Bajrovic, A; Fehlauer, F; Tribius, S; Jung, H; Alberti, W [Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie, Universitaetsklinikum Hamburg-Eppendorf (Germany)

    2004-07-01

    The present analysis shows that the risk of radiogenic plexus brachialis lesion does not decrease but rather remains constant over time. Our series revealed a 2.9% annual rate of newly appearing plexus lesions (p{sub {alpha}}), which is in good agreement with literature data. No significant influence of chemotherapy or tamoxifen treatment on the rate of radiogenic plexus lesions was observed in our series. Within the first five years of radiotherapy (EQD2 59.8 Gy) 3.9% of our patients suffered a lesion of the plexus brachialis. This value is in good keeping with a TD5/5 (5% plexus lesions within 5 years) tolerance dose of 60 - 62 Gy. [German] Die vorliegende Analyse zeigt, dass das Risiko einer radiogenen Plexus-Laesion im Laufe der Zeit nicht abnimmt, sondern konstant bleibt. Die Rate neu aufgetretener Plexus-Laesionen pro Jahr (p{sub a}) von 2,9% in unserer Serie ist mit Daten aus der Literatur vereinbar. Ein signifikanter Einfluss einer Chemotherapie oder einer Tamoxifenbehandlung auf die Rate radiogener Plexus-Laesionen wurde in unserer Serie nicht beobachtet. In den ersten 5 Jahren nach Strahlentherapie (EQD2 59,8 Gy) kam es bei 3,9% unserer Patientinnen zu einer Laesion des Plexus brachialis. Dieser Wert ist gut mit der Toleranzdosis TD5/5 (5% Plexus-Laesionen binnen 5 Jahren) von 60-62 Gy vereinbar. (orig.)

  9. Assessment of potential adjuvanticity of Cry proteins

    NARCIS (Netherlands)

    Joshi, Saurabh S.; Barnett, Brian; Doerrer, Nancy G.; Glenn, Kevin; Herman, Rod A.; Herouet-Guicheney, Corinne; Hunst, Penny; Kough, John; Ladics, Gregory S.; McClain, Scott; Papineni, Sabitha; Poulsen, Lars K.; Rascle, Jean-Baptiste; Tao, Ai-Lin; van Ree, Ronald; Ward, Jason; Bowman, Christal C.

    2016-01-01

    Genetically modified (GM) crops have achieved success in the marketplace and their benefits extend beyond the overall increase in harvest yields to include lowered use of insecticides and decreased carbon dioxide emissions. The most widely grown GM crops contain gene/s for targeted insect

  10. Assessment of potential adjuvanticity of Cry proteins

    DEFF Research Database (Denmark)

    Joshi, Saurabh S; Barnett, Brian; Doerrer, Nancy G

    2016-01-01

    protection, herbicide tolerance, or both. Plant expression of Bacillus thuringiensis (Bt) crystal (Cry) insecticidal proteins have been the primary way to impart insect resistance in GM crops. Although deemed safe by regulatory agencies globally, previous studies have been the basis for discussions around...

  11. Application of radioactive substances in research in nuclear medicine: current trends and radiation exposure to the study subjects; Anwendung radioaktiver Stoffe in der nuklearmedizinischen Forschung: aktuelle Trends und Strahlenexposition der Probanden

    Energy Technology Data Exchange (ETDEWEB)

    Minkov, V.; Schwarz, E.R.; Bauer, B.; Nosske, D.; Erzberger, A.; Brix, G. [Bundesamt fuer Strahlenschutz, Inst. fuer Strahlenhygiene, Abt. fuer Medizinische Strahlenhygiene, Neuherberg (Germany)

    2001-08-01

    the studies showed, for the period of evaluation, an overall trend towards reduction. (orig.) [German] Ziel: Im Rahmen dieser Studie wurde die Anwendung radioaktiver Stoffe am Menschen in der nuklearmedizinischen Forschung und die damit fuer die Probanden verbundene Strahlenexposition analysiert. Methodik: Hierzu wurden die zwischen 1997 und 1999 vom Bundesamt fuer Strahlenschutz zusammen mit dem Bundesinstitut fuer Arzneimittel und Medizinprodukte begutachteten Antraege nach paragraph 41 Strahlenschutzverordnung ausgewertet. Ergebnisse: Der Schwerpunkt der begutachteten Studien zur diagnostischen Anwendung radioaktiver Stoffe hat sich seit 1998 von onkologischen auf neurologisch/psychiatrische Fragestellungen verlagert, wobei die Anzahl der PET-Studien stetig zunahm. Der Anteil der in diagnostische Studien einbezogenen gesunden Probanden ist von 7 auf 22% angestiegen. Therapeutische Anwendungen radioaktiver Stoffe nahmen seit 1997 um das Dreifache zu, wobei der Schwerpunkt im Bereich der Radioimmuntherapie und der endovaskulaeren Brachytherapie lag. Fuer bis zu 49% der untersuchten gesunden Probanden war die effektive Dosis hoeher als 5 mSv, fuer bis zu 6% dieser Probanden lag sie ueber 20 mSv. Bis zu 22% der Patienten erhielten im Rahmen diagnostischer Studien eine effektive Dosis von 20-50 mSv. Eine Ueberschreitung der 50-mSv-Grenze trat bei bis zu 3% der Patienten auf. Schlussfolgerungen: Trotz zunehmender Anwendung der PET behaelt die konventionelle Nuklearmedizin ihre Bedeutung in der medizinischen Forschung. Weiterentwicklungen auf dem Gebiet der Radiochemie und Molekularbiologie fuehrten zu einer zunehmenden Bedeutung der Radioimmuntherapie. Die Evaluierung neuer Radiopharmaka und die Erweiterung der biomedizinischen Grundlagenforschung resultierte in einem Anstieg des Anteils der in die Studien einbezogenen gesunden Probanden. Die studienbedingte Strahlenexposition der Probanden zeigte fuer den ausgewerteten Zeitraum insgesamt einen ruecklaeufigen Trend

  12. Physiological and technical limitations of functional magnetic resonance imaging (fMRI) - consequences for clinical use; Physiologische und technische Grenzen der funktionellen Magnetresonanztomographie und die damit verbundenen Konsequenzen fuer die klinische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Wuestenberg, T. [Neurologische Klinik der Charite, Humboldt-Universitaet Berlin (Germany); Neurologische Klinik der Charite, Humboldt-Universitaet Berlin, Schumannstrasse 20/21, 10117, Berlin (Germany); Jordan, K. [Institut fuer Psychologie II, Otto-von-Guericke-Universitaet Magdeburg (Germany); Giesel, F.L. [Abteilung fuer onkologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum Heidelberg (Germany); Villringer, A. [Neurologische Klinik der Charite, Humboldt-Universitaet Berlin (Germany)

    2003-07-01

    Functional magnetic resonance imaging (fMRI) is the most common noninvasive technique in functional neuroanatomy. The capabilities and limitations of the method will be discussed based on a short review of the current knowledge about the neurovascular relationship. The focus of this article is on current methodical and technical problems regarding fMRI-based detection and localization of neuronal activity. Main error sources and their influence on the reliability and validity of fMRI-methods are presented. Appropriate solution strategies will be proposed and evaluated. Finally, the clinical relevance of MR-based diagnostic methods are discussed. (orig.) [German] Die funktionelle Magnetresonanztomographie (fMRT) ist eines der wichtigsten Verfahren der funktionellen Neuroanatomie. Aufbauend auf einer kurzen Darstellung des aktuellen Wissensstands bzgl. des Zusammenhangs zwischen lokaler neuronaler Aktivitaet und haemodynamischer Reaktion werden ausgewaehlte Moeglichkeiten und Grenzen des Verfahrens fuer die klinische Anwendung diskutiert. Der Schwerpunkt liegt dabei auf der Darstellung der derzeitigen methodischen und technischen Einschraenkungen hinsichtlich einer fMRT-basierten Detektion und Lokalisierung neuronaler Aktivitaet. Es werden die Hauptfehlerquellen und ihre Auswirkungen auf die Reliabilitaet und Validitaet des Verfahrens erlaeutert und aktuelle Loesungsansaetze diskutiert. Abschliessend erfolgt eine Bewertung der aktuellen klinischen Relevanz funktioneller MR-Diagnosemethoden. (orig.)

  13. Environmental protection by cost minimization: Least Cost Planning for traffic. Includes a guide for the application in local communities; Umweltentlastung durch Kostenminimierung: Least Cost Planning im Verkehr. Mit Leitfaden fuer die Anwendung in Kommunen

    Energy Technology Data Exchange (ETDEWEB)

    Bracher, T.; Diegmann, V.; Eckart, C.F.; Liwicki, M.; Lobenberg, G.; Wetzel, C. [Gesellschaft fuer Informatik, Verkehrs- und Umweltplanung mbH (IVU), Berlin (Germany); Bergmann, M.; Uricher, A.; Lueers, A. [Oeko-Institut, Inst. fuer Angewandte Oekologie e.V., Freiburg im Breisgau (Germany); Becker, U.; Karl, G.; Karl, B.; Voellings, A. [Technische Univ. Dresden (Germany). Lehrstuhl fuer Verkehrsoekologie

    1999-08-01

    den Energiesektor entwickelte Least Cost Planning zu uebertragen. Auf der Basis einer Analyse der in der Literatur dokumentierten Ansaetze und der vorhandenen Bewertungsverfahren fuer oeffentliche Massnahmen wurden Anforderungen an Methodik und Entwicklung eines verbesserten Bewertungsverfahrens formuliert. Dieses muss verkehrsmitteluebergreifend (intermodal) und verkehrsuebergreifend (integriert) sein. Das entwickelte Verfahren ermoeglicht erstens die Darstellung der Verkehrsausgaben und Einnahmen einer Stadt im Jahresueberblick, und zweitens die vergleichende Bewertung von Planungsvarianten. Dies wurde anhand verschiedener Varianten fuer die Erschliessung eines Gewerbegebiets im Norden Freiburgs illustriert. Dabei wurden drei Varianten untersucht: die Verlaengerung einer Stadtbahnstrecke, die Verdichtung des Busverkehrsnetzes und die Einrichtung von Service-Stationen und weitere Foerdermassnahmen fuer den Fahrradverkehr. Neben den Berechnungen von Einnahmen und Ausgaben fuer jede Variante wurde eine uebersichtliche Darstellung von Auswirkungen auf die Verkehrsnachfrage, die Belastung mit Luftschadstoffen und Laerm sowie den Flaechenverbrauch entwickelt. Im Ergebnis schneidet die Erschliessung mit dem Fahrrad tendenziell guenstig ab. Der Abschlussbericht umfasst drei Baende sowie einen Leitfaden zur Anwendung des Verfahrens in Kommunen. Dazu gehoert ein Satz Tabellen im Excel Format, der die leichte Anwendung ermoeglicht. (orig.)

  14. Screening of additives for the production of ice pulp for application in normal cooling and freezing; Screening von Zusatzstoffen zur Herstellung von Eisbrei fuer die NK-/TK-Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Ruebeling, Jascha; Eiseler, Jens [Hochschule Karlsruhe - Technik und Wirtschaft (Germany). Inst. fuer Kaelte-, Klima- und Umwelttechnik

    2011-07-01

    The project investigated non-toxic additives for production of ice slurry. Ice slurry is an environment-friendly refrigerant that is increasingly used as a substitute for conventional refrigerants. In view of rising energy prices and an impending tax on climate-relevant refrigerants, ice slurry may soon be used for chilling of food in supermarkets. For this, ice slurry of about 0 C is required for normal cooling and of about -25 C for deep freezing. A very fine-grained, pumpable ice slurry is obtained with glucose as an additive, or with sodium chloride in eutectic concentration with small amounts of ethanol for deep freezing. Ethanol will refine the coarse crystal structure of the eutectic sodium chloride / water mixture and will also reduce the freezing point. Further, the method of primary crystallisation on a crystallised additive was developed. An industrial plant working by this principle will have less disturbances and wear during ice slurry production. [German] Die Projektarbeit befasste sich mit der Untersuchung lebensmittelvertraeglicher Additive zur Herstellung von Eisbrei. Eisbrei gilt als umweltfreundlicher Kaeltetraeger, der zunehmend in verschiedenen Bereichen zur Anwendung kommt und herkoemmliche Kaeltemittel ersetzen kann. Aufgrund steigender Energiekosten sowie einer eventuell anstehenden Besteuerung treibhauswirksamer Kaeltemittel, kann Eisbrei zukuenftig zur Kuehlung von Lebensmitteln in Supermaerkten verwendet werden. Dazu wird Eisbrei mit ca. 0 C fuer die Normalkuehlung, beziehungsweise mit ca. -25 C fuer die Tiefkuehlung benoetigt. Mit Glucose als Zusatzstoff laesst sich ein sehr feinkoerniger und damit pumpbarer Eisbrei fuer die Normalkuehlung erzeugen. Bei der Tiefkuehlung ist Natriumchlorid in einer eutektischen Konzentration mit geringen Mengen Ethanol empfehlenswert. Ethanol verfeinert die grobe Kristallstruktur des reinen eutektischen Natriumchlorid-Wasser-Gemisches und senkt den Gefrierpunkt. Des Weiteren wurde das Verfahren der

  15. Avaliação da qualidade de vida e toxicidades em pacientes com câncer colorretal tratados com quimioterapia adjuvante baseada em fluoropirimidinas Evaluation of the toxicity and quality of life in patients with colorectal cancer treated with chemotherapy

    Directory of Open Access Journals (Sweden)

    Vanessa Maria Nunes Roque

    2006-06-01

    Full Text Available RACIONAL: O câncer colorretal é a quarta causa de câncer no Brasil e o 5-fluourouracil uma das principais drogas usadas no tratamento adjuvante e paliativo dessa doença. A toxicidade da quimioterapia e as alterações de qualidade de vida, causadas pela própria doença e pelo tratamento, são motivo de muitos estudos. OBJETIVO: Avaliar nos doentes com câncer colorretal em tratamento quimioterápico, a toxicidade e possíveis alterações da qualidade de vida. MÉTODOS: Durante o período de março de 2001 a maio de 2003 no Ambulatório de Oncologia da Disciplina de Gastroenterologia Clínica da Universidade Federal de São Paulo, foram acompanhados 45 pacientes com câncer colorretal em tratamento quimioterápico adjuvante ou paliativo com 5-fluourouracil e ácido folínico durante seis ciclos. A toxicidade gastrointestinal e hematológica foi analisada utilizando-se as Recomendações para a Graduação da Toxicidade Aguda e Subaguda. Após o término de cada ciclo quimioterápico, os resultados foram anotados de acordo com os respectivos graus que variaram entre 0 e 4. A qualidade de vida foi pesquisada pelo questionário WHOQOL bref (World Health Organization Quality of Life que consta de 26 questões e é composto por 4 domínios: físico, psicológico, relações sociais e meio ambiente, no início, no 3° e no 6° ciclo de tratamento. RESULTADOS: Entre os 45 pacientes, 28 eram do sexo masculino, a média de idade foi de 58,4 anos (34 a 79 anos. Segundo a classificação da União Internacional Contra o Câncer, 34 (75,6% eram estádio II ou III e 11 estádio IV (24,4%. Quanto à localização, 64,4% eram de cólon. Em 57,7% a quimioterapia foi adjuvante e nos demais paliativa. As toxicidades mais comumente encontradas foram náuseas (42%, diarréia (38% e neutropenia (15,7%. Não houve diferença significante entre os graus de toxicidade nos diferentes ciclos, assim como entre os doentes em tratamento adjuvante ou paliativo. Quanto

  16. Revisão sistemática do uso da dexametasona como terapia adjuvante na meningite bacteriana em crianças Revisión sistemática del uso de la dexametasona como terapia adyuvante en la meningitis bacteriana en niños Systematic review of dexamethasone as an adjuvant therapy for bacterial meningitis in children

    Directory of Open Access Journals (Sweden)

    João Antonio G. G. Prats

    2012-12-01

    Full Text Available OBJETIVO: Analisar a melhor evidência disponível nos últimos 15 anos com relação aos benefícios da terapia adjuvante com dexametasona na meningite bacteriana em população pediátrica. FONTES DE DADOS: Das bases de dados Medline, Lilacs e SciELO, foram analisados ensaios clínicos randomizados de 1996 a 2011, os quais comparavam a dexametasona ao placebo e/ou a outra terapia adjuvante em pacientes com meningite bacteriana diagnosticada laboratorialmente por critérios quimiocitológicos e/ou bacteriológicos, na faixa etária de 29 dias aos 18 anos. Os desfechos avaliados foram mortalidade e ocorrência de sequelas neurológicas e/ou auditivas. Foram excluídos estudos relacionados à meningite tuberculosa. SÍNTESE DOS DADOS: Com os critérios utilizados, foram identificadas cinco publicações correspondentes a quatro protocolos de estudo. Nenhum dos estudos mostrou diferenças entre a dexametasona e o placebo para os desfechos avaliados. Os estudos analisados tiveram alta qualidade (escore de Jadad et al=5. CONCLUSÕES: As evidências encontradas na literatura são insuficientes para indicar de forma rotineira o uso da dexametasona como terapia adjuvante para redução de mortalidade, perda auditiva e sequelas neurológicas em pacientes pediátricos com meningite bacteriana não tuberculosa.OBJETIVO: El presente estudio tiene por objetivo el análisis de la mejor evidencia disponible los últimos 15 años respecto a los beneficios de la terapia adyuvante con dexametasona en la meningitis bacteriana en población pediátrica por medio de revisión sistemática. FUENTES DE DATOS: De las bases de datos Medline, Lilacs y ScieLO, se analizaron ensayos clínicos aleatorios de 1996 a 2011 que comparaban la dexametasona al placebo y/u otra terapia adyuvante, en pacientes con meningitis bacteriana diagnosticada laboratorialmente por criterios quimiocitológicos y/o bacteriológicos, en la franja de edad de 29 días a 18 años. Los desenlaces

  17. Radiotherapy for MTRA/RT; Strahlentherapie fuer MTRA/RT

    Energy Technology Data Exchange (ETDEWEB)

    Luetter, Christiana [Bonn Univ. (Germany). Radiologische Klinik

    2012-07-01

    The radiological practice textbook covers the following issues: tumor diseases, tumor diagnostics, fundamentals of radiotherapy, DIN, irradiation planning, documentation and quality assurance, strategies of tumor therapy, basic physics of radiotherapy and dosimetry, radiation protection - regulations and guidelines, radiobiology, biological radiation effects, special organ toxicity, psychological and medical attendance of patients, special oncology of the most important organ carcinomas, palliative radiotherapy, radiotherapy of benign diseases, other indications of radiotherapy, supportive therapy.

  18. Subcutaneous immunization against Leishmania major - infection in mice: efficacy of formalin-killed promastigotes combined with adjuvants Imunização subcutânea na infecção do camundongo pela Leishmania major: eficácia dos promastigotos mortos pela formalina combinada com adjuvantes

    Directory of Open Access Journals (Sweden)

    Joshua M. Mutiso

    2010-04-01

    Full Text Available Formalin-killed promastigotes (FKP of Leishmania major, in combination with Montanide ISA 720 (MISA, BCG or alum were used in vaccination of an inbred murine model against cutaneous leishmaniasis (CL. Significant and specific increases in anti-FKP IgG responses were detected for both alum-FKP and BCG-FKP compared to MISA-FKP (p Promastigotos mortos pela formalina (FKP de Leishmania major combinados com Montanide ISA 720 (MISA, BCG ou alumen foram usados na vacinação de modelo murino cutâneo de leishmaniose (CL. Aumento significante e específico de resposta IgG anti FKP foram detectados tanto no FKP com alumen como naquele com BCG comparados ao MISA-FKP (p < 0,001. Aumento significante da proliferação esplênica de linfócitos de memória foi obtida nos camundongos vacinados com MISA-FKP quando comparados aos grupos vacinados com alumen-FKP ou BCG-FKP (p < 0,01. As maiores respostas por interferon-gama foram observadas no grupo BCG-FKP seguido pelo MISA-FKP enquanto que o alumen-FKP deu a menor resposta. No grupo MISA-FKP foram obtidas reduções significantes do tamanho das lesões quando comparado aos grupos vacinados com BCG/adjuvante de alumen-FKP. Embora o grupo BCG-FKP tenha mostrado a maior resposta por interferon-gama, não houve controle das lesões cutâneas. Redução significante no número de parasitas foi observada tanto no grupo vacinado com MISA-FKP como no BCG-FKP (p < 0,001. Houve boa correlação entre a carga parasitária e o nível de interferon-gama indicando que a resposta do interferon-gama é parâmetro sensível do estado imunológico. Em conclusão, MISA-FKP é a forma mais eficaz de vacina contra a leishmaniose cutânea murina.

  19. Use of mannanoligosacharides as an adjuvant treatment for gastrointestinal diseases and this effects on E.coli inactivated in dogs Uso de mananoligossacarídeos fosforilados como adjuvante no tratamento de doenças gastrointestinais e seu efeito na inativação da E. coli em cães

    Directory of Open Access Journals (Sweden)

    Eliana Maria Ferreira Gouveia

    2006-01-01

    : Constatou-se a efetividade do Mos no grupo tratado, quando houve a eliminação da Escherichia coli patogênica em 85,71% dos animais,enquanto que, no grupo sem o Mos, só 25%, não apresentaram o microorganismo. CONCLUSÃO: O Mos é efetivo no controle da E. coli patogênica, sendo indicado como tratamento adjuvante nas gastroenterites.

  20. Anwendung des autogenen Trainings im Kindesalter

    OpenAIRE

    Sühling, Nikola

    2004-01-01

    The autogenic training was developed by J.H.Schulz in the period between 1912-1920 based on the experiences of his hypnosis patients. These reported of a regular occurrence of certain perceptions at the beginning of the treatment. J.H.Schulz derived six exercises from this experience, through which the patient is said to get relaxed. Among others these exercises contain the idea to get warm and heavy arms and legs. Furthermore, physical reactions in the abdomen, thorax and the head will be in...

  1. Stimmrehabilitation und Psychotherapie - Anwendung bei Lehrern

    OpenAIRE

    Niebudek-Bogusz, E; Śliwinska-Kowalska, M

    2005-01-01

    Voice disorders in teachers are not only a serious medical but also social and economic problem in Poland. It has been shown that teachers are at risk of developing occupational dysphonia which account for over 25% of all occupational diseases diagnosed in Poland. Voice problems affects psychological wellbeing of teachers, while psychological factors may induce escalation of voice pathologies in this professional group. The study was aimed to assess the effectiveness of phoniatric treatment i...

  2. Cost-effectiveness of anastrozole, in comparison with tamoxifen, in the adjuvant treatment of early breast cancer in Brazil Custo-efetividade do anastrozol em comparação com tamoxifeno no tratamento adjuvante do câncer de mama precoce no Brasil

    Directory of Open Access Journals (Sweden)

    Marcelo Fonseca

    2009-01-01

    Full Text Available OBJECTIVE: Breast cancer, a leading type of cancer in many developing countries, is the most frequent non-cutaneous tumor in Brazil. Hormone therapy is the standard of care in the adjuvant treatment of early-stage, hormone-receptor-positive disease, and both tamoxifen and third-generation aromatase inhibitors are options in postmenopausal women. The comparative cost-effectiveness of different treatment strategies is of considerable interest in societies facing limited resources. METHODS: In an attempt to compare cost-effectiveness of upfront treatment with tamoxifen or anastrozole, the medical and economic results in a hypothetical cohort of 64-year-old postmenopausal women, was analyzed considering the Brazilian healthcare system in 2005, the primary perspective of the private sector, and a lifetime horizon. Data from the ATAC Trial, Markov modeling, a modified Delphi panel, and microcosting (in Brazilian R$ were used to estimate costs and effectiveness of the two upfront strategies. RESULTS: The model estimated a gain of 0.55 discounted life-years for patients receiving anastrozole, relative to those treated with tamoxifen. With an incremental cost of R$ 15,141.15, the model estimated that the cost-effectiveness of anastrozole, in relation to tamoxifen, was R$ 27,326.80. Monte Carlo simulations showed that approximately 50% of the cases fell below the threshold of R$ 29,229.00 per life-year gained, which is recommended by the World Health Organization for Brazil. CONCLUSION: It was concluded that upfront anastrozole is a cost-effective option compared with tamoxifen in the adjuvant treatment of postmenopausal women with hormone-receptor-positive early breast cancer.RESUMO OBJETIVO: O câncer de mama, o mais comum em vários países desenvolvidos, é o tumor não cutâneo mais frequente no Brasil. A terapia hormonal é o tratamento adjuvante padrão para os estágios precoces, em doença com receptor hormonal positivo, e o tamoxifeno e os

  3. Adjuvantes:Un componente esencial de las vacunas de Neisseria

    Directory of Open Access Journals (Sweden)

    Reinaldo Acevedo

    2009-08-01

    Full Text Available Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis caused by Neisseria meningitidis serogroups, particularly serogroup B, continues to be a global health problem. Novel strategies have applied in silico and recombinant technologies to develop "universal" antigens (e.g. proteins, peptides and plasmid DNA for vaccines, but these antigens have been shown to be poorly immunogenic even when alum adjuvanted, implying a need for better vaccine design. In this work we review the use of natural, detoxified, or synthetic molecules in combination with antigens to activate the innate immune system and to modulate the adaptive immune responses. In the main, antigenic and imune potentiator signals are delivered using nano-, micro-particles, alum, or emulsions. The importance of interaction between adjuvants and antigens to activate and target dendritic cells, the bridge between the innate and adaptive immune systems, will be discussed. In addition, nasal vaccine strategies based on the development of mucosal adjuvants and Neisseria derivatives to eliminate the pathogen at the site of infection provide promising adjuvants effective not only against respiratory pathogens, but also against pathogens responsible for enteric and sexually transmitted diseases.

  4. Adjuvanticity of vitamin A in advanced irradiated cervical cancer

    International Nuclear Information System (INIS)

    Kucera, H.; Micksche, M.; Vienna Univ.

    1982-01-01

    For treatment of patients with inoperable cervical cancer (FIGO III) a randomized trial has been initiated. Patients were randomized to receive either conventional irradiation therapy together with vitamin A palmitate (1.5 mill. I.U./day; total dose: 30 mill. I.U.), applied orally, or irradiation alone. When lymphocyte reactivity to PHA (maximum response during therapy) was compared within the groups, it was found, that 66% of the patients who received irradiation combined with vitamin A palmitate, showed an increase in their blastogenic response, while in irradiated patients without vitamin A palmitate a response was seen only in 33%. This difference being statistically significant in comparison to pretreatment values. From immunological data it can be concluded, that vitamin A has an effect on functional response on T-cells. Concerning the clinical outcome, after an observation period of 12 months relapse rates were lower in the vitamin A group, but not significantly reduced. Therefore further follow up is warranted. (orig.) [de

  5. Qualidade de vida de pacientes com câncer colorretal em terapia adjuvante Calidad de vida de pacientes con cáncer de rectocolon en terapia adyuvante Quality of life of patients with colorectal cancer who were receiving complementary therapy

    Directory of Open Access Journals (Sweden)

    Adriana Cristina Nicolussi

    2009-01-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida, identificar os domínios afetados nos pacientes com câncer colorretal, caracterizar os dados sócio-demográficos, clínicos e terapêuticos e correlacioná-los aos domínios da qualidade de vida. MÉTODOS: Estudo transversal, realizado no Centro Especializado de Oncologia de Ribeirão Preto com 22 pacientes com câncer colorretal em terapia adjuvante, entre julho/ 2006 a setembro/ 2007. Utilizou-se o instrumento Quality of Life Core-30-Questionnaire. RESULTADOS: A qualidade de vida foi considerada satisfatória (média = 79,13. Os domínios mais afetados foram: Função Emocional e sintomas dor, insônia, fadiga. Nas correlações, as mulheres destacaram-se negativamente, apresentando piores escores nas Funções Emocional, Cognitiva e sintomas: dor, insônia, fadiga, constipação e perda de apetite. Os pacientes em radioterapia relataram mais dor e os assintomáticos à quimioterapia são os que obtiveram melhor qualidade de vida geral. CONCLUSÃO: A qualidade de vida foi satisfatória, relativamente pior nas mulheres, em radioterapia e que apresentaram efeitos colaterais da quimioterapia.OBJETIVO: Evaluar la calidad de vida, identificar los dominios afectados en los pacientes con cáncer de rectocolon, caracterizar los datos socio-demográficos, clínicos y terapéuticos y correlacionarlos a los dominios de la calidad de vida. MÉTODOS: Estudio transversal, realizado en el Centro Especializado de Oncología de Ribeirão Preto con 22 pacientes con cáncer de rectocolon en terapia adyuvante, entre julio/ 2006 a setiembre/ 2007. Se utilizó el instrumento Quality of Life Core-30-Questionnaire. RESULTADOS: La calidad de vida fue considerada satisfactoria (media = 79,13. Los dominios más afectados fueron: Función Emocional y síntomas dolor, insomnio, fatiga. En las correlaciones, las mujeres se destacaron negativamente, presentando peores escores en las Funciones Emocional, Cognitiva y síntomas: dolor

  6. Avaliação da Densidade dos anestésicos locais e da combinação com adjuvantes: estudo em laboratório Evaluación de la densidad de los anestésicos locales y de la combinación con adyuvantes: estudio en laboratorio Assessment of the densities of local anesthetics and their combination with adjuvants: an experimental study

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Imbelloni

    2009-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Uma das mais importantes propriedades físicas que afetam o nível da analgesia obtida após a injeção subaracnoidea de um anestésico local é sua densidade relativa à densidade do líquido cefalorraquidiano (LCR a 37°C. O objetivo deste trabalho foi determinar a densidade das soluções de anestésicos locais com e sem glicose e a combinação de anestésico local com adjuvantes a 20°C, 25°C e 37°C em avaliação laboratorial. MÉTODO: A densidade (g.mL-1 foi medida como auxílio de um densímetro DMA 450, sensível a ± 0,00001 g.mL-1. A densidade e suas variações com a temperatura foram obtidas de todos os anestésicos locais e suas combinações com opioides a 20°C, 25°C e 37°C. A solução é hiperbárica se sua densidade excede a 1,00099, a solução é hipobárica quando a densidade está abaixo de 1,00019 e é isobárica quando a densidade é maior que 1,00019 e menor que 1,00099. RESULTADOS: Ambos, anestésicos locais e adjuvantes, exibem diminuição da densidade quando se aumenta a temperatura. A 37°C, todas as soluções que contêm glicose são hiperbáricas. Na ausência de glicose, todas as soluções são hipobáricas. A 37°C, morfina, fentanil, sufentanil e clonidina são hipobáricas. CONCLUSÕES: A densidade dos anestésicos locais e adjuvantes diminui com o aumento da temperatura e aumenta com a adição de glicose. O conhecimento da baricidade, densidade relativa, ajuda na seleção do anestésico local mais adequado e dos adjuvantes para uso subaracnoideo.JUSTIFICATIVA Y OBJETIVOS: Una de las más importantes propiedades físicas que afectan el nivel de la analgesia obtenida después de la inyección subaracnoidea de un anestésico local, es su densidad relativa a la densidad del líquido cefalorraquídeo (LCR a 37°C. El objetivo de este trabajo fue determinar la densidad de las soluciones de anestésicos locales con y sin glucosa y la combinación de anestésico local con

  7. UIS Baden-Wuerttemberg. AJA project. Application of JAVA-based solutions in environment, transport and administration. Phase II 2001; UIS Baden-Wuerttemberg. Projekt AJA. Anwendung JAVA-basierter Loesungen in den Bereichen Umwelt, Verkehr und Verwaltung. Phase II 2001

    Energy Technology Data Exchange (ETDEWEB)

    Mayer-Foell, R.; Keitel, A.; Geiger, W. (eds.)

    2001-12-01

    Information and communication technology facilitates data acquisition, recording, evaluation and transmission in many fields of society, but even experts tend to get lost in the flood of data that are available. In order to make it possible to integrate new technological developments in information systems, the Minister of Environment and Transportation continues the project AJA (''Application of JAVA-based solutions'') which was started in 2000. AJA is a sequel to the GLOBUS project which was terminated in 1999. (GLOBUS - Globale Umweltsachdaten im UIS Baden-Wuerttemberg und anderen Systemen). [German] Die Bereiche Umwelt, Verkehr und Verwaltung profitieren bei der Erhebung, Erfassung, Auswertung, Darstellung und Weitergabe ihrer Daten in hohem Masse von Informations- und Kommunikationstechnik (IuK). Manche Darstellungsweisen und Berechnungen werden dadurch erst moeglich. Uebergreifende Zusammenhaenge koennen mit Hilfe der IuK aufgezeigt werden. Die Verwaltung muss Technologien einsetzen, wie sie in der Wirtschaft fuer die Zusammenfuehrung von verteilten Unternehmensdaten verwendet werden, um Entscheidungs grundlagen fuer die Unternehmenspolitik zu liefern (z.B. Data Warehouse). In solchen ''Warenhaeusern von Daten'' finden sich oft nur Experten zurecht. Unsere Herausforderung ist es, diese komplexen Zusammenhaenge nicht nur dem Experten, sondern auch dem Buerger auf moeglichst einfache und wirtschaftliche Weise zu vermitteln. Dem Buerger ist der freie Zugang zu Informationen ueber die Umwelt zu ermoeglichen. Wir sind damit auf dem Wege zu einem Marktplatz von Daten und Informationen fuer den Buerger und die Verwaltung. Um neue technologische Entwicklungen in Informationssystemen einsetzen zu koennen, fuehrt das Ministerium fuer Umwelt und Verkehr (UVM) das 2000 begonnene FuE-Vorhaben AJA ''Anwendung JAVA-basierter Loesungen'' fort. AJA baut auf dem 1999 abgeschlossenen Vorhaben GLOBUS (Globale

  8. Determination of specific concentration variations of atmospheric trace elements in precipitation as a method for the estimation of spatial deposition into the soil by use of statistical methods; Ermittlung spezifischer Konzentrationsverlaeufe atmosphaerischer Spurenbestandteile in Niederschlaegen als Methode zur Abschaetzung des flaechenhaften Stoffeintrags in den Boden unter Anwendung statistischer Methoden

    Energy Technology Data Exchange (ETDEWEB)

    Busch, U. [Dortmund Univ. (Germany). Fachbereich Statistik; Vautz, W. [Institut fuer Spektrochemie und Angewandte Spektroskopie (ISAS), Dortmund (Germany); Klockow, D. [Institut fuer Spektrochemie und Angewandte Spektroskopie (ISAS), Dortmund (Germany); Urfer, W. [Dortmund Univ. (Germany). Fachbereich Statistik

    1995-08-01

    Witterungsdaten - und die genauere Abschaetzung der raeumlichen Verteilung von Stoffkonzentrationen in Niederschlaegen. Schliesslich wird ein Interpolationsverfahren fuer Depositionsdaten vorgeschlagen, das die geschaetzten Parameter dieser Modelle und Witterungsdaten als zusaetzliche Information verwendet. Seine Anwendung auf die Daten von 1992 ergibt erste Depositionskarten. Der Bericht schliesst mit einigen Vorschlaegen, wie die Ergebnisse aus diesem Projekt in zukuenftigen Untersuchungen zur trockenen Deposition verwendet werden koennten. (orig.)

  9. MR-Imaging optimisation of the articular hip cartilage by using a T{sub 1}-weighted 3-dimensional gradient-echo sequence and the application of a hip joint traction; Magnetresonanztomographische Optimierung der Hueftknorpeldarstellung durch die Wahl einer T{sub 1}-Volumen-Gradienten-Echo-Sequenz und die Anwendung einer Hueftgelenkstraktion

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, R. [Heidelberg Univ. (Germany). Orthopaedische Klinik und Poliklinik; Bernd, L. [Heidelberg Univ. (Germany). Orthopaedische Klinik und Poliklinik; Wrazidlo, W. [ATOS-Praxisklinik, Heidelberg (Germany). Radiologische Gemeinschaftspraxis Drs. Lederer, Schneider und Wrazidlo; Lederer, W. [ATOS-Praxisklinik, Heidelberg (Germany). Radiologische Gemeinschaftspraxis Drs. Lederer, Schneider und Wrazidlo; Schneider, S. [ATOS-Praxisklinik, Heidelberg (Germany). Radiologische Gemeinschaftspraxis Drs. Lederer, Schneider und Wrazidlo

    1995-10-01

    Images of three animal cadaver hips, 8 dissected patient femoral heads and 18 hip joints of human corpses, all either with arthrosis stage I-III or artificial cartilage defects, were compared with their corresponding anatomic sections. Additional histomorphologic examinations of the arthrotic cartilages were conducted, and MR-Imaging of 20 healthy and 21 arthrotic patient hips was performed using a specific traction method. Using a T{sub 1}-weighted 3-dimensional gradient-echo sequence and a traction of the hip joint, it was possible due to the low-signal imaging of the joint space to separate in vivo the high-signal femoral head cartilage from the high-signal acetabular cartilage. In horizontal position of the phase-encoding parameter, minimisation of the chemical-shift artifact, mainly in the ventro-lateral areas, was accomplished. MRI measurements of the articular cartilage widths showed significant correlations (p < 0.001) with the corresponding anatomic sections. At the same time the T{sub 1} 3-dimensional gradient-echo sequence of the lateral femoral head with r = 0.94 showed the lowest deviations of the measurements. It was possible with MR-Imaging to distinguish four cartilage qualities. (orig./MG) [Deutsch] Im experimentellen Teil der Studie wurden den MRT-Bildern von drei Kadavertierhueften, 8 resezierten Patientenhueftkoepfen und 18 Leichenhueftgelenken, an denen entweder artifizielle Knorpeldefekte gesetzt wurden oder die ein Koxarthrose-Stadium I-III aufwiesen, die korrespondierenden makroskopischen Kryomikrotomschnitte zugeordnet. Bei den Koxarthrosen erfolgten zusaetzliche histomorphologische Knorpeluntersuchungen. Im klinischen Teil der Studie wurden 20 gesunde und 21 arthrotische Probandenhueftgelenke mit einem speziellen Traktionsverfahren untersucht. Unter Anwendung einer T{sub 1}-Volumen-Gradienten-Echo-Sequenz und einer Traktion am zu untersuchenden Hueftgelenk konnte in vivo durch die signalarme Darstellung des Gelenkspaltes der

  10. Development and application of dynamic MR-imaging for evaluation of perfusion changes in rectal carcinoma during a course of radiotherapy in clinical use. Preliminary results; Entwicklung und Anwendung dynamischer MRT-Messungen zur Evaluierung von Perfusionsveraenderungen bei Rektumkarzinomen unter Bestrahlung in der klinischen Routine. Erste Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Vries, A. de; Griebel, J.; Gneiting, T.; Hoflehner, J.; Brandl, M.; Lukas, P. [Leopold-Franzens-Univ. Innsbruck (Austria). Universitaetsklinik fuer Strahlentherapie - Radioonkologie; Judmaier, W.; Kremser, C.; Schocke, M.; Aichner, F. [Leopold-Franzens-Univ. Innsbruck (Austria). Inst. fuer Magnetresonanztomographie; Peer, S.; Rettl, G. [Leopold-Franzens-Univ. Innsbruck (Austria). Universitaetsklinik fuer Radiodiagnostik I; Oefner, D. [Leopold-Franzens-Univ. Innsbruck (Austria). Universitaetsklinik fuer Chirurgie; Debbage, P. [Leopold-Franzens-Univ. Innsbruck (Austria). Inst. fuer Histologie und Embryologie

    1999-11-01

    procedures. (orig.) [German] Ziel: Entwicklung und Anwendung dynamischer Magnetresonanztomographiemessungen zur Erhebung von Perfusionsparametern bei Rektumkarzinomen unter Bestrahlung in der klinischen Routine. Patienten und Methode: Bei Rektumkarzinompatienten (n=8), die sich einer praeoperativen kombinierten Radiochemotherapie unterzogen, wurden Perfusionsdaten erhoben. An einem 1,5-Tesla-Ganzkoerperkernspintomographen wurden ultraschnelle T1-Mapping-Sequenzen zum Erhalt von T1-Maps mit Intervallen von 14 und 120 Sekunden implementiert. Die Messzeit der dynamischen Messungen betrug 40 Minuten. Die Messschicht (Schichtdicke 5 mm) wurde so gewaehlt, dass sowohl Tumor als auch arterielle Gefaesse dargestellt wurden. Gadolinium-DTPA-(Gd-DTPA-)Konzentrations-Zeit-Kurven wurden nach einem prolongierten Bolus im arteriellen Blut und im Tumor berechnet. Die angewendete Methode erlaubte eine raeumliche Aufloesung von 2x2x5 mm und eine zeitliche Aufloesung von 14 Sekunden. Die Messdaten wurden vor und in konstanten Intervallen waehrend Therapie erhoben. Ergebnisse: Die raeumliche und zeitliche Aufloesung der T1-Maps war ausreichend, um Areale mit unterschiedlicher Kontrastmittelkinetik innerhalb des Tumors zu erfassen sowie die grossen Beckenarterien sicher zu identifizieren. Bei sechs Patienten konnten Gd-DTPA-Konzentrationskurven im Tumor unter Therapie erhoben werden. Der Perfusionsindex (Pi) versus Strahlendosis zeigte eine signifikante Zunahme in der ersten oder zweiten Woche der Bestrahlung, bevor er entweder kontinuierlich absank oder nach anfaenglichem Abfall einen erneuten Anstieg aufwies. Der durchschnittliche Pi-Ausgangswert betrug 0,16 ({+-}0,049), das durchschnittliche Pi-Maximum war 0,23 ({+-}0,058). Die relativen Perfusionsveraenderungen betrugen zwischen 20 und 83%. Schlussfolgerung: Unsere Ergebnisse zeigen, dass sich die verwendete Methode zur Erfassung von Perfusionsparametern unter Bestrahlung eignet und in der klinischen Routine anwendbar ist. In der Zukunft

  11. UIS Baden-Wuerttemberg. Project AJA. Application of JAVA-based and other efficient solutions in the areas of environment, traffic and administration. Phase V 2004; UIS Baden-Wuerttemberg. Projekt AJA. Anwendung JAVA-basierter und anderer leistungsfaehiger Loesungen in den Bereichen Umwelt, Verkehr und Verwaltung. Phase V 2004

    Energy Technology Data Exchange (ETDEWEB)

    Mayer-Foell, R.; Keitel, A.; Geiger, W. (eds.)

    2004-12-01

    Bundeslaendern die Umsetzung von Verwaltungsreformen - in Baden-Wuerttemberg der Vollzug des Verwaltungsstruktur-Reformgesetzes (VRG) - sowie die Umsetzung von e-Government-Konzepten derzeit zu zusaetzlichen Anforderungen an die Verwaltung und ihre IuK-Technik. Durch den Einsatz innovativer Informationstechnologien kann in vielen Bereichen ein bedeutender Beitrag zur Erfuellung dieser Anforderungen geleistet werden; genannt seien hier Portal-, Content-Management- und Integrations-Technologien sowie neue Techniken fuer den Web-basierten und mobilen Zugriff auf Informationen. Entwicklung uf Pflege der neuen Informations- und Kommunikationssysteme erfordern oft nicht unerhebliche Mittel. Aufgrund der knappen Haushaltslage der Gebietskoerperschaften koennen diese Mittel von den einzelnen zustaendigen Stellen zunehmend nicht mehr aufgebracht werden. Auch wuerden Einzelentwicklungen nicht den Anforderungen zum sparsamen Umgang mit Haushaltsmitteln und groesstmoeglicher Effektivitaet der eingesetzten Mittel entsprechen. Ein wichtiges Mittel, um diese Herausforderung zu bewaeltigen, ist die verstaerkte Zusammenarbeit der Gebietskoerperschaften bei der Entwicklung und Pflege der Informationssysteme. Um die Zusammenarbeit innerhalb des Landes Baden-Wuerttemberg sowie mit dem Bund und anderen Laendern zu foerdern, wurde Ende 1999 das F+E-Projekt AJA (Anwendung JAVA-basierter und anderer leistungsfaehiger Loesungen in den Bereichen Umwelt, Verkehr und Verwaltung) gegruendet. Das Projekt AJA ist im Jahr 2004 in seine fuenfte Phase gegangen und wird mit dieser Phase abgeschlossen. Der vorliegende Bericht ist die Projektdokumentation der Phase V von AJA im Jahr 2004. Er gibt die Aufgabenstellungen und die Ergebnisse der 19 F+E-Arbeiten wieder. (orig.)

  12. Turbulence models development and engineering applications; Turbulenzmodellentwicklung und ingenieurtechnische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Groetzbach, G.; Ammann, T.; Dorr, B.; Hiltner, I.; Hofmann, S.; Kampczyk, M.; Kimhi, Y.; Seiter, C.; Woerner, M.; Alef, M.; Hennemuth, A.

    1995-08-01

    The FLUTAN code is used for analyzing the decay heat removal in new reactor concepts. The turbulence models applied in FLUTAN are improved by the development of the TURBIT code. TURBIT serves for a numerical simulation of turbulent channel flow. (orig.)

  13. Sensors - technology and application. Sensoren - Technologie und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    The development of sensors could not keep pace with the progress made in microelectronics. The monolithic integration of sensor and signal processing circuits was realised in some cases. More development is needed though before they can be applied in microelectronics, household appliances and automobiles. Descriptions are supplied of: new materials and technologies for sensors, sensor systems, sensors for mechanical parameters, temperatures, chemical paramters and sensors on magnetic basis.

  14. Smoothed Bootstrap und seine Anwendung in parametrischen Testverfahren

    Directory of Open Access Journals (Sweden)

    Handschuh, Dmitri

    2015-03-01

    Full Text Available In empirical research, the distribution of observations is usually unknown. This creates a problem if parametric methods are to be employed. The functionality of parametric methods relies on strong parametric assumptions. If these are violated the result of using classical parametric methods is questionable. Therefore, modifications of the parametric methods are required, if the appropriateness of their assumptions is in doubt. In this article, a modification of the smoothed bootstrap is presented (using the linear interpolation to approximate the distribution law suggested by the data. The application of this modification to statistical parametric methods allows taking into account deviations of the observed data distributions from the classical distribution assumptions without changing to other hypotheses, which often is implicit in using nonparametric methods. The approach is based on Monte Carlo method and is presented using one-way ANOVA as an example. The original and the modified statistical methods lead to identical outcomes when the assumptions of the original method are satisfied. For strong violations of the distributional assumptions, the modified version of the method is generally preferable. All procedures have been implemented in SAS. Test characteristics (type 1 error, the operating characteristic curve of the modified ANOVA are calculated.

  15. Experimental radiotherapy and clinical radiobiology. Vol. 16; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 16. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, M; Dahm-Daphi, J; Dikomey, E; Petersen, C; Rodemann, H P; Zips, D [eds.

    2007-07-01

    The following topics were dealt with: DNA repair as therapeutical target in radiation therapy, biological imaging and tumor microenvironment, molecular factors of radiation therapy, molecular factors and modulation of the radiation reaction of normal tissues, experimental tumor therapy, EGFR inhibition, the endothel cell as primary target of radiation therapy, molecular and cellular foundations of the radiation biology of protons and ions. (HSI)

  16. Experimental radiotherapy and clinical radiobiology. Vol. 19. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 19. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemann, H Peter; Zips, Daniel [eds.

    2010-12-18

    The proceedings include review contributions on radio-oncology, and new radiation technologies and molecular prediction; and poster sessions on the following topics: hypoxia; molecular mechanisms of radiation resistance; molecular targeting; DNA repair; biological imaging; biology of experimental radiations; normal tissue toxicity; modern radiotherapy; tumor hypoxia and metabolic micro milieu; immune system and radiotherapy.

  17. Experimental radiotherapy and clinical radiobiology. Vol. 22. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 25. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Krause, Mechthild [Universitaetsklinikum Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologie; Cordes, Nils [Universitaetsklinikum Technische Univ. Dresden (Germany). OncoRay - Nationales Zentrum fuer Strahlenforschung in der Radioonkologie; Helmholtz-Zentrum Dresden-Rossendorf e.V., Dresden (Germany); Petersen, Cordula [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Rodemann, H. Peter [Universitaetsklinikum Tuebingen (Germany). Sektion fuer Strahlenbiologie; Rothkamm, Kai [Universitaetsklinikum Hamburg-Eppendorf, Hamburg (Germany). Lab. fuer Strahlentherapie und Experimentelle Radioonkologie; Zips, Daniel (ed.) [Tuebingen Univ. (Germany). Universitaetsklinik fuer Radioonkologie

    2016-05-01

    The proceedings of the 25th symposium on experimental radiotherapy and clinical radiobiology include papers on the following issues: radiotherapy individualization based on imaging; pre-clinic imaging and new experimental methods; methods and models, micromilieu and metabolism, combined therapy; secondary tumors following radiotherapy; radiogenic effects in normal tissue; resistance mechanism of tumors and normal tissue; personalized radio-oncology - which biological data are needed; pre-clinic and personalized radio-oncology; biomarkers - pre-clinic and translational; translational examinations for personalized radio-oncology.

  18. Results of radiation therapy in periarthritis humeroscapularis; Ergebnisse der Strahlentherapie bei Periarthropathia humeroscapularis

    Energy Technology Data Exchange (ETDEWEB)

    Schultze, J.; Schlichting, G.; Galalae, R.; Kimmig, B. [Klinik fuer Strahlentherapie (Radioonkologie), Universitaetsklinikum Schleswig-Holstein, Kiel (Germany); Koltze, H. [Radiologische Gemeinschaftspraxis, Celle (Germany)

    2004-07-01

    Background: radiation therapy is applied in painful degenerative shoulder diseases. Aim of this work was to evaluate the contribution of radiation therapy to symptomatic improvement in periarthritis humeroscapularis. Methods: ninety-four patients with periarthritis humeroscapularis were treated in two institutions. Mean age was 68 years, sex distribution were 32 men and 62 women. In 58 cases the right side was affected, left in 36 cases. At single doses of 0,75 Gy once a week a total dose of 6 Gy was applied The treatment effect was evaluated by the standardized von Pannewitz-score at the end of the treatment up to 6 months thereafter. Results: the treatment results of all the 94 patients were documentated at the end of therapy. Seventy-one patients were followed at least for further 4 months. Radiogenic side-effects were not noticed. The symptoms of 54 patients (57.4%) were improved or vanished, in 40 cases the symptoms were not significantly affected (42.6%). Four months after therapy 42 of 71 patients were improved (59.2%), 29 unchanged (40.8%). The treatment effect occured typically up to 2 months after therapy, there were no age-related differences. Also in recurrent radiation therapies the symptoms improved, in 80 percent after one preceding therapy, however only in 31.2 percent after multiple prior radiotherapies. (orig.)

  19. Experimental radiotherapy and clinical radiobiology. Vol. 18. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 18. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemann, H Peter; Zips, Daniel [eds.

    2009-07-15

    The proceedings on experimental radiotherapy and clinical radiobiology contain two review articles (prediction of normal tissue reactions after radiotherapy, ?H2AX foci as a marker for DNA double-strand breaks) and 34 contributions to the following topics: Hypoxia and molecular mechanisms of radiation resistance; biological imaging of the tumor micromilieu; DNA repair, genomic instability and carcerogenesis; molecular factors of radiation resistance; actual controversial discussion on possible irradiation caused metastasis risk enhancement; EGFR inhibition and irradiation; biology of experimental radiation/ normal tissue toxicity.

  20. Experimental radiotherapy and clinical radiobiology. Vol. 20. Proceedings; Experimentelle Strahlentherapie und Klinische Strahlenbiologie. Bd. 20. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, Michael; Dahm-Daphi, Jochen; Dikomey, Ekkehard; Petersen, Cordula; Rodemannn, Hans-Peter; Zips, Daniel (eds.)

    2011-07-01

    The proceedings include contributions on the following issues: laser driven proton accelerators on the way for radiotherapy, radiobiological evaluation of new radiations; molecular factors of radiation response; biological targeting; EGFR epidermal growth factor receptor/targeting - combined internal and external irradiation, radiobiology of normal tissues; dose-volume histograms for the radiotherapy: curves without radiobiological relevance or important information for the therapy planning; HPV (human papilloma virus) and radiation sensitivity of HNSCC (head and neck squamous cell carcinomas): evidence, radiobiological mechanism, clinical consequences and perspectives; mechanisms of action and intertumoral heterogeneity of response to EGFR inhibition in radiotherapy of solid tumors; evaluation of biomarkers for radiotherapy.

  1. Novel tracer for radiation treatment planning; Welche neuen PET-Tracer braucht die Strahlentherapie?

    Energy Technology Data Exchange (ETDEWEB)

    Schwarzenboeck, S.; Krause, B.J. [Rostock Univ. (Germany). Klinik fuer Nuklearmedizin; Herrmann, K.; Gaertner, F.; Souvatzoglou, M. [Technische Univ. Muenchen (Germany). Klinik fuer Nuklearmedizin; Klaesner, B. [Klinikum Bogenhausen, Muenchen (Germany). Inst. fuer Radiologie und Nuklearmedizin

    2011-07-15

    PET and PET/CT with innovative tracers gain increasing importance in diagnosis and therapy management, and radiation treatment planning in radio-oncology besides the widely established FDG. The introduction of [{sup 18}F]Fluorothymidine ([{sup 18}F]FLT) as marker of proliferation, [{sup 18}F]Fluoromisonidazole ([{sup 18}F]FMISO) and [{sup 18}F]Fluoroazomycin-Arabinoside ([{sup 18}F]FAZA) as tracer of hypoxia, [{sup 18}F]Fluoroethyltyrosine ([{sup 18}F]FET) and [{sup 11}C]Methionine for brain tumour imaging, [{sup 68}Ga]DOTATOC for somatostatin receptor imaging, [{sup 18}F]FDOPA for dopamine synthesis and radioactively labeled choline derivatives for imaging phospholipid metabolism have opened novel approaches to tumour imaging. Some of these tracers have already been implemented into radio-oncology: Amino acid PET and PET/CT have the potential to optimise radiation treatment planning of brain tumours through accurate delineation of tumour tissue from normal tissue, necrosis and edema. Hypoxia represents a major therapeutic problem in radiation therapy. Hypoxia imaging is very attractive as it may allow to increase the dose in hypoxic tumours potentially allowing for a better tumour control. Advances in hybrid imaging, i.e. the introduction of MR/PET, may also have an impact in radio-oncology through synergies related to the combination of molecular signals of PET and a high soft tissue contrast of MRI as well as functional MRI capabilities. (orig.)

  2. Clonidina como droga adjuvante no tratamento da síndrome de abstinência alcoólica em unidade de terapia intensiva: relato de caso Clonidina como droga coadyuvante en el tratamiento de la síndrome de abstinencia alcohólica en unidad de terapia intensiva: relato de un caso Clonidine as adjuvant therapy for alcohol withdrawal syndrome in intensive care unit: case report

    Directory of Open Access Journals (Sweden)

    Leandro Gobbo Braz

    2003-12-01

    uso adjuvante de clonidina conseguiu proporcionar tratamento adequado ao paciente.JUSTIFICATIVA Y OBJETIVOS: La sedación de dependientes de alcohol y drogas en Unidades de Terapia Intensiva (UTI es un desafío por la elevada incidencia de tolerancia a las drogas sedativas y de la elevada frecuencia de síndromes de abstinencia. El objetivo de este relato es mostrar un caso de un paciente joven admitido en la UTI que desarrolló síndrome de abstinencia alcohólica y tolerancia a las drogas sedativas, solucionadas solamente después del uso de clonidina. RELATO DEL CASO: Paciente del sexo masculino, 18 años, dependiente de alcohol, tabaco, cocaína y mariguana, víctima de accidente por arma de fuego, fue admitido en la UTI en el 1º día de post-operatorio de enterectomía, después de aspiración de contenido gástrico durante reintubación traqueal. Evolución clínica: drogas vasoactivas hasta el 4º día de internación y broncopneumonia bilateral con derrame pleural y necesidad de ventilación artificial hasta el 15º día. El esquema de sedación inicial utilizado fue la asociación de midazolan y fentanil. A partir del 4º día, el paciente presentó varios episodios de agitación psicomotora, mismo con la asociación de loracepam en el 6° día. En el 9° día, el paciente recibió las mayores dosis de los fármacos, más permanecía agitado. Se optó por la asociación de dexmedetomidina, que redujo las dosis de las otras drogas en 35% y diminuyó la agitación. En el 12° día, el midazolan y la dexmedetomidina fueron substituidos por la infusión de propofol, con empeoramiento del cuadro. En el 13° día, fue asociada clonidina al esquema de sedación, con resolución del cuadro de agitación. En el 14° día, el propofol fue suspenso, siendo mantenida la infusión de fentanil y reintroducida la infusión de midazolan, con dosis respectivamente 75% y 65% menores en relación al pico de uso de estas drogas. En el 15° día, el paciente fue extubado y tuvo

  3. Dexmedetomidina como droga adjuvante no despertar transitório no intra-operatório de correção cirúrgica de escoliose: relato de caso Dexmedetomidina como droga adyuvante en el despertar transitorio en el intra-operatorio de corrección quirúrgica de escoliosis: relato de caso Dexmedetomidine as adjuvant drug for wake-up test during scoliosis correction surgery: case report

    Directory of Open Access Journals (Sweden)

    Airton Bagatini

    2004-04-01

    procedimento, a paciente permaneceu no estágio 3 de sedação de Ramsay, isto é, sob analgesia, respirando espontaneamente e tranqüila. CONCLUSÕES: A dexmedetomidina associada à anestesia venosa total mostrou-se uma opção interessante, como droga adjuvante no teste de despertar, bem como para o propósito de analgesia e sedação no período perioperatório.JUSTIFICATIVA Y OBJETIVOS: La escoliosis es un defecto de la columna vertebral que necesita muchas veces de corrección quirúrgica. Una peculiaridad de esta corrección es la necesidad del paciente despertar en el intra-operatorio y movimentar los miembros inferiores con la finalidad de alejar lesiones del SNC después de la corrección del defecto ortopédico. En este relato, fue asociada dexmedetomidina a la anestesia venosa total con propofol y remifentanil con el objetivo de obtener las acciones sedativa, analgésica y de estabilidad ventilatoria de esta droga, durante el despertar transitorio en paciente sometida a corrección quirúrgica de escoliosis. RELATO DE CASO: Paciente del sexo femenino, 16 años, blanca, estado físico ASA I, con escoliosis torácica y lumbar en 12 niveles, fue sometida a cirugía sobre anestesia general. Como medicación pre-anestésica fue utilizado lorazepam en la dosis de 2 mg, por vía oral, en la víspera y 90 minutos antes del procedimiento. Después de monitorización, fue realizada venóclisis y punción de la arteria radial en el miembro superior izquierdo; la vena subclávia derecha fue punzionada con catéter de duplo lumen, para infusión de drogas y medidas hemodinámicas. La inducción anestésica fue hecha con 1 µg.kg-1 de remifentanil y propofol, en infusión alvo-controlada, para concentración plasmática de 3 µg.ml-1. Como bloqueador neuromuscular, fue utilizado atracúrio en la dosis de 0,5 mg.kg-1. La manutención de la anestesia fue realizada con infusión continua de dexmedetomidina (0,4 µg.kg-1.h-1, remifentanil (0,3 µg.kg-1.min-1 y propofol (3 µg.ml-1 en

  4. Use of inactivated E.Coli enterotoxins to enhance respiratory mucosal adjuvanticity during vaccination in swine

    Science.gov (United States)

    In order to augment responses to respiratory vaccines in swine, various adjuvants were intranasally co-administered with an antigen to pigs. Detoxified E. coli enterotoxins LTK63 and LTR72 enhanced mucosal and systemic immunity to the model peptide, exhibiting their efficacy as mucosal adjuvants for...

  5. Effecten en kosten van adjuvante chemotherapie bij operabele lymfklierpositieve borstkanker met HER2/neu-overexpressie

    NARCIS (Netherlands)

    Vos, E. J.; Linn, S. C.; Rodenhuis, S.

    2006-01-01

    Newer forms ofadjuvant chemotherapy can considerably improve the prognosis for breast cancer. The benefits that can be achieved are particularly high for young women ( <50 years) with an unfavourable risk profile (tumour-positive axilliary nodes). The recent application of taxans and trastuzumab has

  6. Radiotherapy and radiooncology: An interdisciplinary approach. 4. tot. new rev. and enl. ed.; Strahlentherapie und Radioonkologie aus interdisziplinaerer Sicht

    Energy Technology Data Exchange (ETDEWEB)

    Karstens, J.H.; Bremer, M.; Meyer, A.; Warszawski, A.; Bruns, F. (eds.) [Medizinische Hochschule Hannover (Germany). Abt. fuer Strahlentherapie und Spezielle Onkologie

    2005-07-01

    This is the 4th, completely revised edition of the successful book on modern cancer therapy. The focus of this edition is on interdisciplinary cooperation. Current knowledge, both legal and medical, is presented in a clear and well-structured form. The text is supplemented by many illustrative drawings and pictures. The book addresses students and other readers interested in oncology and provides useful and detailed information on radiation therapy of benign and malignant diseases. (orig.)

  7. Radiation therapy for Morbus Ledderhose - indication and clinical results; Strahlentherapie beim Morbus Ledderhose - Indikation und klinische Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H.; Attassi, M. [Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin, Alfried-Krupp-Krankenhaus, Essen (Germany)

    2003-12-01

    Background: morbus ledderhose (ML) is a rare hyperproliferative disorder of the plantar aponeurosis which is similar in its clinical course to morbus dupuytren (MD). We examined whether radiotherapy (RT) can effect symptoms and prevent disease progression. Patients and methods: from June 1996 to December 2001, 25 patients (12 female/13 male) aged 9-76 (median: 56) years had radiotherapy (RT) for symptomatic ML. Follow-up (FU) was at least 1 year. 36 feet (16 right/20 left) were treated, as eleven patients had bilateral disease. Twelve (48%) patients had MD. There were 63 nodules (with 0,5-6,5 cm diameter) on all feet and 20 cords (with 1-4 cm length) on 13 (52%) feet prior to RT. 21 (84%) patients had one or more signs: 14 (56%) severe local pain, eight (32%) walking difficulties, twelve (48%) other symptoms, pressure or tension sensation. The RT field involved all nodules and cords plus safety margin. Two RT-series were applied (each 5 x 3 gy in 1 week) separated by 8-12 weeks up to a total dose of 30 gy. Evaluation was performed at the end of RT, after 3 and 12 months FU and in December 2002. The primary endpoint was prevention of disease progression and avoidance of surgery. Secondary endpoints were objective changes of morphological and functional parameters and patient's satisfaction measured on a visual analogue scale (VAS). Results: with a median FU of 38 (12-67) months no patient experienced progression or underwent surgery: 11 of 36 (44%) feet had a reduced number (overall: - 16) or size of nodules, 7 of 13 (54%) feet had a reduced number (overall: -9) or length of cords; gait was improved in six of twelve (50%) feet; pain was reduced or had completely disappeared in 9 of 15 (60%) feet, and other symptoms disappeared in 8 of 18 (44%) symptomatic feet. 20 (80%) patients regarded 28 of 36 (78%) treated feet as improved and 8 (22%) in stable condition. The median relative improvement stated by patients on the VAS was 50% (0-100%). Treatment side effects were minimal: during and within 3 months of the RT course only a slight erythema (CTC 1 ) was seen in five treated lesions, while dry skin changes within the RT portal were observed in three cases (11%) in long term FU (> 12 months). Conclusions: radiotherapy is effective in treating ML and may prevent otherwise necessary surgical interventions. Nodules, cords and symptoms regress, but long-term outcome of at least 5 years has to be awaited. Prospective phase III studies should confirm these results. (orig.) [German] Hintergrund: Der morbus ledderhose (ML) ist eine hyperproliferative Erkrankung der Plantaraponeurose, die dem morbus dupuytren (MD) sehr aehnlich ist. Wir prueften, ob eine Bestrahlung die Symptome lindern und die Progression der Erkrankung aufhalten kann. Patienten und Methoden: Von Juni 1996 bis Dezember 2002 wurden zwoelf Frauen und 13 Maenner im Alter von 9-76 (median 56) Jahren mit symptomatischem ML bestrahlt und mindestens 1 Jahr kontrolliert. Insgesamt wurden 36 Fuesse (16 rechts, 20 links) bestrahlt, da elf Patienten beidseits einen Befall hatten. Zwoelf (48%) Patienten hatten auch einen MD. An 36 Fuessen lagen 63 Knoten (mit 0,5-6,5 cm Groesse) und an 13 (52%) Fuessen 20 Straenge (mit 1-4 cm Laenge) vor. Zusaetzlich bestanden 14-mai (56%) starke Fussschmerzen, achtmal (32%) Probleme beim Laufen, zwoelfmal (48%) andere Symptome (Druck, Schwellung, Spannung). Die Orthovolt-Radiotherapie erfasste alle tastbaren Knoten und Straenge. Es wurden zwei Serien zu je 5 x 3 Gy pro Woche (gesamt: 30 Gy) im Abstand von 8-12 Wochen gegeben. Die Auswertung erfolgte am Ende der RT, nach 3 und 12 Monaten und zuletzt im Dezember 2002. Primaerer Endpunkt war die Vermeidung einer Progression bzw. Operation; sekundaere Endpunkte waren mehrere objektive morphologisch-funktionelle sowie subjektive Parameter (visuelle analogskala (VAS)). Ergebnisse: Nach 38 (12-67) Monaten medianem FU war kein Fuss progredient oder musste operiert werden. Bei 11 von 36 (44%) Fuessen nahm die Zahl (minus 16) oder die Groesse der Knoten und bei 7 von 13 (54%) Fuessen die Zahl (-9) oder die Laenge der Straenge ab; normale Gehfunktion erreichten sechs von zwoelf (50%) Fuessen; die Schmerzen verschwanden ganz oder teilweise bei 9 von 15 (60%) Fuessen, die uebrigen Symptome verschwanden bei 8 von 18 (44%) Fuessen. Fuer 28 von 36 (78%) Fuessen gaben 20 (80%) Patienten eine Besserung an, die uebrigen blieben stabil. Die Verbesserung erreichte im Median 50% (0-100%) auf der VAS. Die Nebenwirkungen waren insgesamt gering: Waehrend und bis zu 3 Monaten nach der RT hatten fuenf (14%) Fuesse eine leichte Hautroetung (CTC 1 ) im RT-Feld; bei drei (8%) Fuessen blieb die Haut langfristig (> 12 Monate) trocken. Schlussfolgerungen: Die Bestrahlung ist bei ML wirksam und sollte noch vor einer Operation eingesetzt werden. Knoten, Straenge und Symptome koennen sich zurueckbilden. Langzeitstudien und prospektive multizentrische Studien muessen diese Resultate noch bestaetigen. (orig.)

  8. Rules and regulations applying to incidents in radiotheraphy; Rechtliche Grundlagen fuer den Umgang mit sicherheitsrelevanten Ereignissen in der Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Lohr, F. [Universitaetsmedizin Mannheim, Heidelberg Univ., Mannheim (Germany). Klinik fuer Strahlentherapie und Radioonkologie; Baus, W. [Uniklinik Koeln (Germany). Klinik und Poliklinik fuer Strahlentherapie; Vorwerk, H. [Universitaetsklinikum Marburg-Giessen, Marburg Univ. (Germany). Klinik fuer Strahlentherapie; Schloemp, B. [Berufsverband der Medizinisch-Technischen Radiologieassistenten (MTRA) in der Radioonkologie (VMTRO), Berlin (Germany); Andre, L. [Lindenhofspital Bern (Switzerland); Georg, D. [Universitaetsklinik fuer Strahlentherapie der Medizinischen Univ. Wien/AKH Wien, Vienna (Austria). Abt. fuer Medizinische Strahlenphysik; Hodapp, N. [Universitaetsklinikum Freiburg, Freiburg Univ. (Germany). Klinik fuer Strahlenheilkunde

    2012-07-15

    Aims and purpose: Radiotherapy is an essential and reliable element of the treatment armamentarium in oncology. Numerous rules, regulations, and protocols minimize the associated risks. It can, however, never be excluded that errors in the treatment delivery chain result in inadequate tumor doses or unnecessary damage to organs at risk. A legal framework governs the management of such incidents. The most important European and North American regulations are reported. Results: Various directives issued by the European Union are differently implemented nationally. This applies particularly to the characterization of incidents that must be reported to authorities. Reporting thresholds, audit systems, and the extent of the integration of voluntary reporting systems vary. Conclusion: Radiotherapy incidents are dealt with differently on an international level. Changes are to be expected based on the European Basic Safety Standards Directive that is currently being prepared and will have to be implemented nationally in due course. (orig.)

  9. A special radiation shielding for the radiotherapy of a pregnant patient; Eine Spezialabschirmung fuer die Strahlentherapie von Schwangeren

    Energy Technology Data Exchange (ETDEWEB)

    Buchgeister, M.; Mondry, A. [Bereich Medizinische Physik, Universitaetsklinik fuer Radioonkologie, Tuebingen (Germany); Spillner, P.; Paulsen, F.; Belka, C.; Bamberg, M. [Strahlentherapie, Universitaetsklinik fuer Radioonkologie, Tuebingen (Germany)

    2008-02-15

    Purpose: measurement of the radiation dose of different radiotherapy techniques with a phantom at the position of the uterus of a pregnant patient with and without a special radiation shielding. Material and methods: a special radiation shielding for the radiation therapy of a pregnant patient was constructed in the shape of a tunnel over the abdomen from 1 cm thick lead to reduce scatter radiation to the uterus and the fetus therein. The reduction of the scatter radiation to the lower abdomen was measured for three typical cases (cerebrum with lateral opposed fields, 6-MV photons; tangential fields for mamma irradiation, 6 MV; and anteroposterior-posteroanterior [AP-PA] opposed fields of 15 MV for treatment of the mediastinum) at an anthropomorphic Alderson phantom with thermoluminescence dosimeters in different depths and with an ionization chamber positioned in an RW3 solid water phantom. In the case of lateral opposed fields, a movable lead wall was additionally positioned next to the accelerator's head to reduce the scatter radiation from this source. Results: depending on the geometry of the radiation fields and on the photon energy, a reduction of the dose to the lower abdomen averaged over the depths of 6, 9, and 12 cm from 16% (15 MV, mediastinum case) to 51% (6 MV, cerebrum with additional lead wall) was achieved. The absolute scattered dose with shielding in place for a 2-Gy fraction dose results to 3.85 mGy and 0.27 mGy, respectively. Conclusion: national and international recommendations on the radiation dose to a fetus of a pregnant patient state limits of 200 mSv (DGMP report no. 7) and 100 mGy (ICRP 84), below which an abortion should not be considered and above which an indication for termination of the pregnancy could be given, respectively. The dose to the fetus can be kept below these limits with the shielding described in this work. Therefore, a radiation therapy of a pregnant patient is possible when these special precautions to reduce the scatter radiation to the fetus are met. (orig.)

  10. Individual quality of life in patients undergoing radiotherapy. A longitudinal survey; Individuelle Lebensqualitaet von Strahlentherapie-Patienten. Eine Laengsschnittuntersuchung

    Energy Technology Data Exchange (ETDEWEB)

    Wenskus, Julia Katharina

    2015-07-01

    The way that Quality of Life (QoL) is perceived has crucially changed over the last few decades. As a consequence of demographic change and ongoing technical progress, QoL gained in importance and became established as a major outcome parameter in clinical trials. Scientists in the field of QoL differentiate between three categories: health-related, global and individual QoL. For the assessment of individual QoL, Becker et al. (2014) and Merk (2011) developed and validated an easily applicable and economical questionnaire; the SEIQoL-Q. The purpose of our study was to modify the SEIQoL-Q based on Merk's approach (2011) and apply the revised version in a longitudinal survey of different patient populations in the Clinic for Radiotherapy of the University Hospital of Freiburg. Apart from that, other crucial factors, which might affect the evaluation of one's QoL, were gathered by use of a newly established questionnaire. 132 patients undergoing radiotherapy and having been diagnosed with breast cancer (BC), prostate cancer (PC), bone metastasis (BM) or a benign disease (B) were included in our study. The participants were interviewed at four definitive times in their treatment (1. before the radiotherapy had started, 2. after 50 % of the total radiation dose had been given, 3. at the end of the therapy, 4. during the aftercare). A total of 419 interviews were carried out. While the highest possible score was 100, the average individual QoL was 60.48 (BC: 56.55; PC: 64.13; BM: 59.27; B: 58.85). Significant differences of the individual QoL were revealed between the diagnosis groups (BC vs. PC, PC vs. B, PC vs. BM), the age (< 66 years: 55.39; = 66 years: 62.27) and the gender (women: 57.11; men: 62.88). Additionally, the expectations and the mood influenced the assessment of the individual QoL. Furthermore, it could be shown that there were correlations between the individual QoL and personality, depressive tendencies, ego strength, optimism, self-concept, faith and coping strategies. Our data show that the subjective sensitivity does not correlate with objective results like the given diagnosis or the intention of the treatment. Tools to measure the individual QoL are suitable to contribute to the process of a multimodal diagnostic and therapy concept and thereby help to view and treat the patient as well as the concerned relatives in their entirety.

  11. Results of radiotherapy with different doses in epicondylitis humeri. Ergebnisse der Strahlentherapie der Epicondylitis humeri bei unterschiedlicher Dosierung

    Energy Technology Data Exchange (ETDEWEB)

    Kammerer, R.; Bollmann, G.; Schwenger, P.; Michael, G.; Koeppen, D. (Klinik fuer Radiologie, Medizinische Akademie Magdeburg (Germany))

    1990-01-01

    In a prospective analysis the effectiveness of roentgen irradiation with minimal doses (daily single dosis 0.3Gy up to a total dose of 1.5Gy) was investigated in 207 patients with an epicondylitis humeri. Compared with a group of 92 patients, who were irradiated with higher doses beeing in general use (weekly 2 x single dosis 1.0 Gy to a total dose of 4.0 Gy), the therapeutic results show no sihnificant differences. After termination of the first irradiation series an improvement of complaints was seen in half of the patients (48.8% or 50.0%). A further increase of the quota in success to 74.9% or 70.6% was found 6 weeks after termination or irradiation. By reason of radiotherapeutic results, mainly attained in chronic states of epicondylitis humeri after primary conservative therapy without success for months and partly surgical pretreatment, the radiotherapy should be used more frequently than till now, especially in consideration of its slight side-effects and injuries of patients. (orig.).

  12. Radiation therapy of benign diseases: patterns of care study in Germany; Strahlentherapie von gutartigen Erkrankungen: eine Bestandsaufnahme fuer Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H. [Alfried Krupp Krankenhaus Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Katalinic, A. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Medizinische Statistik und Dokumentation; Makoski, H.B. [Staedtische Kliniken Duisburg (Germany). Strahlenklinik; Haase, W. [St. Vincentius Krankenhaus Karlsruhe (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Gademann, G. [Magdeburg Univ. (Germany). Klinik fuer Strahlentherapie; Hassenstein, E. [Krankenhaus Nordwest, Frankfurt am Main (Germany). Radioonkologische Klinik

    1999-11-01

    A questionnaire was mailed in 3 years (1994, 1995, 1996) to all radiation facilities in Germany, which assessed equipment, indications, number of patients and treatment concepts. A total of 134 (88%) institutions returned all requested data: 22 in East and 112 in West Germany; 30 in university and 104 in community/private hospitals. The average data of each institution and of all institutions were analyzed for frequencies and ratios between different regions and institutions. A mean of 2 (range 1 to 7) megavoltage (Linac/Cobalt 60) and 1.4 (range 0 to 4) orthovoltage units were available per institution; 32 (24%) institutions had no orthovoltage equipment. A mean of 20,082 patients were treated per year: 456 (2%) for inflammatory diseases (221 hidradenitis, 78 nail bed infection, 23 parotitis, 134 not specified), 12,600 (63%) for degenerative diseases (2,711 peritendinitis humeroscapularis, 1,555 epicondylitis humeri, 1,382 heel spur, 2,434 degenerative osteoarthritis, 4,518 not specified), 927 (5%) for hypertrophic diseases (146 Dupuytren's contracture, 382 keloids, 155 Peyronie's disease, 244 not specified), 1,210 (6%) for functional disorders (853 Graves' orbitopathy, 357 not specified), and 4,889 (24%) for other disorders (e.g. 3,680 heterotopic ossification prophylaxis). In univariate analysis, there were significant geographical (West vs East Germany) differences in the use of radiotherapy for inflammatory and degenerative disorders and institutional differences (university vs community/private hospitals) in the use of radiotherapy for hypertrophic and functional disorders (p<0.05). The prescribed dose concepts were mostly in the low dose range (<10 Gy), but varied widely and inconsistently within geographic regions and institution types. (orig./MG) [German] 1994, 1995 und 1996 wurde an alle strahlentherapeutischen Institutionen in Deutschland ein Fragebogen verschickt, mit dem technische Ausstattung, Indikationsspektrum, Patientenzahl und Therapiekonzepte bei gutartigen Erkrankungen erhoben wurden. 134 (88%) Institutionen (22 in Ost-, 112 in Westdeutschland; 30 in Universitaets-, 104 in oeffentlichen/privaten Krankenhaeusern) beantworteten alle Fragen. Die Haeufigkeiten und Durchschnittswerte pro Institution und ueber alle Institutionen hinweg wurden hinsichtlich geographischer Region und Krankenhaustyp analysiert. Im Durchschnitt standen zwei (Spanne 1 bis 7) Linearbeschleuniger/Kobaltgeraete und 1,4 (Spanne 0 bis 4) Orthovoltgeraete pro Institution zur Verfuegung; 32 (24%) besassen kein Orthovoltgeraet. Pro Jahr wurden im Mittel 20 082 Patienten behandelt: 456 (2%) wegen Entzuendungen (221 Hidradenitis, 78 Panaritium, 23 Parotitis, 134 nicht differenziert), 12 600 (63%) wegen degenerativer Erkrankungen (2 711 Peritendinitis humeroscapularis, 1 555 Epicondylopathia humeri, 1 382 Fersensporn, 2 434 arthrotische Erkrankungen, 4 518 nicht differenziert), 927 (5%) wegen hypertrophischer Erkrankungen (146 Morbus Dupuytren, 382 Keloide, 155 Induratio penis plastica, 244 nicht differenziert), 1 210 (6%) wegen funktioneller Erkrankungen (853 endokrine Orbitopathie, 357 nicht differenziert), 4 889 (24%) wegen anderer Erkrankungen und institutionelle Unterschiede (Universitaets- vs. Versorgungskrankenhaeuser) bei hypertrophischen und funktionellen Erkrankungen (p<0,05). Die meisten Therapiekonzepte waren im Niedrigdosisbereich (<10 Gy) angelegt, schwankten aber im Detail unsystematisch und in weiten Grenzen. (orig./MG)

  13. Operation and adjuvante radiotherapy of oropharyngeal carcinomas. Clinical results at the University of Wuerzburg between the years 1998-2010; Operation und adjuvante Bestrahlung bei Oropharynx- und Mundhoehlenkarzinomen. Klinische Ergebnisse an der Universitaet Wuerzburg aus den Jahren 1998-2010

    Energy Technology Data Exchange (ETDEWEB)

    Rosenheim, Eva

    2016-09-20

    Results of a retrospective study at the University of Wuerzburg: Patients and methods: In a retrospective study the factors of influence on the locoregional control, the overall survival and the disease free survival of 106 patients with histological approved oropharyngeal cancer were tested with uni- and multivariate analysis. The median age at the date of the primary diagnosis was 55 years. A median follow up surveillance of 36 months could be achieved (between 5 to 126 months). In 18 cases (17%) the primary tumor could be removed in sano (safety margin >3mm). In 34 cases (32%) were detected close resection margins (<3mm) and in 54 cases the resection margins were not free of tumor cells (R1 resection). Patients, who were treated with chemotherapy, because of the increased recurrency risk, were 24% of the patient database. The concept of medical treatment: The tumorbed of the primary tumor and the cervical lymphatic drain received a radiation dose of 56 Gy (2 Gy/ treatment, 5 fractions a week). Patients with R0 resections received doses from 56 to 60 Gy. Patients with close resections margins received a higher dose of 60 to 66 Gy at the tumorbed and patients with R1 resections were treated with a boost up to 66 to 70 Gy. Patients with UICC 4 status with an increased recurrency risk received an additional chemotherapy with cisplatin (40mg/m{sup 2} a week) in 1 to 4 cycles as well a boost of the tumorbed up to 66 to 70 Gy. In the univariate analysis with the Kaplan-Maier Plat method following factors of influence were detected: tumor status (p-value 0,003), lymph node status (p-value 0,048), chemotherapy (p-value 0,047), second tumor (p-value 0,003) and the overall tumor volume (p-value 0,000). Results of the multivariate analysis In the Cox regression analysis the tumor status and the development of a second tumor were detected as factors of influence of the 5 year overall survival rate and the 5 year disease free survival survival rate. Regarding to the overall survival rate for the tumor status was detected a statistical significance of 0,015 and regarding the disease free survival was detected a significance of 0,025. The factor of influence of the second tumor had a significance for the overall survival of 0,015 and a significance regarding the disease free survival of 0,025. Conclusion: With the concept of medical treatment there could be achieved an improvement of the 5 year overall survival and the 5 year disease free survival. Patients with close resection margins had throughout better results as patients with a R0 resection. The consequence of those results should be an adjustment of the present concept of medical treatment of the R0 patients to the concept of patients with close resection margins. Patients who received a simultaneous radiochemotherapy, because of the increased risk of recurrence, the present concept of medical treatment effected an adjustment of the 5 year overall survival rate to patients without an increased risk of recurrence. There was no statistical significance in the multivariate analysis at the overall survival as well as at the disease free survival (overall survival p-value 0,064, disease free survival p-value 0,085).

  14. Built-in adjuvanticity of genetically and protein-engineered chimeric molecules for targeting of influenza A peptide epitopes.

    Science.gov (United States)

    Kerekov, Nikola S; Ivanova, Iva I; Mihaylova, Nikolina M; Nikolova, Maria; Prechl, Jozsef; Tchorbanov, Andrey I

    2014-10-01

    Highly purified, subunit, or synthetic viral antigens are known to be weakly immunogenic and potentate only the antibody, rather than cell-mediated immune responses. An alternative approach for inducing protective immunity with small viral peptides would be the direct targeting of viral epitopes to the immunocompetent cells by DNA vaccines encoding antibody fragments specific to activating cell surface co-receptor molecules. Here, we are exploring as a new genetic vaccine, a DNA chimeric molecule encoding a T and B cell epitope-containing influenza A virus hemagglutinin peptide joined to sequences encoding a single-chain variable fragment antibody fragment specific for the costimulatory B cell complement receptors 1 and 2. This recombinant DNA molecule was inserted into eukaryotic expression vector and used as a naked DNA vaccine in WT and CR1/2 KO mice. The intramuscular administration of the DNA construct resulted in the in vivo expression of an immunogenic chimeric protein, which cross-links cell surface receptors on influenza-specific B cells. The DNA vaccination was followed by prime-boosting with the protein-engineered replica of the DNA construct, thus delivering an activation intracellular signal. Immunization with an expression vector containing the described construct and boosting with the protein chimera induced a strong anti-influenza cytotoxic response, modulation of cytokine profile, and a weak antibody response in Balb/c mice. The same immunization scheme did not result in generation of influenza-specific response in mice lacking the target receptor, underlining the molecular adjuvant effect of receptor targeting.

  15. Synthesis, Formulation, and Adjuvanticity of Monodesmosidic Saponins with Olenanolic Acid, Hederagenin and Gypsogenin Aglycones, and some C-28 Ester Derivatives

    DEFF Research Database (Denmark)

    Greatrex, Ben W.; Daines, Alison M.; Hook, Sarah

    2015-01-01

    In an attempt to discover a new synthetic vaccine adjuvant, the glycosylation of hederagenin, gypsogenin, and oleanolic acid acceptors with di- and trisaccharide donors to generate a range of mimics of natural product QS-21 was carried out. The saponins were formulated with phosphatidylcholine...... of cholesterol and phospholipid, the choline ester derivatives produced nanocrystalline rods or helical micelles. The effects of modifying sugar stereochemistry and the aglycone on the immunostimulatory effects of the saponins was then evaluated using the activation markers MHC class II and CD86 in murine bone...... marrow dendritic cells. The most active saponin, 3-O-(Manp(13)Glcp)hederagenin, was stimulatory at high concentrations in cell culture, but this did not translate to strong responses in vivo....

  16. O uso da L-carnitina como adjuvante no tratamento da miocardiopatia dilatada em criança com Aids

    OpenAIRE

    Zanoni,Lourdes Zélia; Oliveira,Ana Lúcia L.; Cônsolo,Luiz Carlos T.; Cônsolo,Carlos Eduardo Z.; Espíndola,Yara Delamare

    2011-01-01

    OBJETIVO: Apresentar a resposta cardiovascular à L-carnitina de um paciente com insuficiência cardíaca congestiva decorrente de miocardiopatia dilatada pelo vírus da imunodeficiência humana. DESCRIÇÃO DO CASO: Criança com quadro clínico de insuficiência cardíaca congestiva grave devido à miocardiopatia dilatada pela síndrome de imunodeficiência adquirida. O tratamento para as manifestações clínicas foi instituído, com pouca resposta clínica. Com objetivo de melhorar o desempenho energético/me...

  17. Complications following surgery and adjuvant irradiation in rectal carcinoma. Komplikationen nach Operation und nach adjuvanter Bestrahlung beim Rektumkarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Suhr, P.; Limmer, J. (Ulm Univ. (Germany, F.R.). Universitaetsklinikum)

    1991-04-12

    Colorectal cancer is one of the most common human malignancies. Adjuvant irradiation can decrease the risk of recurrence and subsequently the associated morbidity compared with surgery alone. The rate of radiation-induced complications amounts to approximately 10%, which is substantially lower than the frequency of observed local failure. (orig.).

  18. Operation and adjuvante radiotherapy of oropharyngeal carcinomas. Clinical results at the University of Wuerzburg between the years 1998-2010

    International Nuclear Information System (INIS)

    Rosenheim, Eva

    2016-01-01

    Results of a retrospective study at the University of Wuerzburg: Patients and methods: In a retrospective study the factors of influence on the locoregional control, the overall survival and the disease free survival of 106 patients with histological approved oropharyngeal cancer were tested with uni- and multivariate analysis. The median age at the date of the primary diagnosis was 55 years. A median follow up surveillance of 36 months could be achieved (between 5 to 126 months). In 18 cases (17%) the primary tumor could be removed in sano (safety margin >3mm). In 34 cases (32%) were detected close resection margins (<3mm) and in 54 cases the resection margins were not free of tumor cells (R1 resection). Patients, who were treated with chemotherapy, because of the increased recurrency risk, were 24% of the patient database. The concept of medical treatment: The tumorbed of the primary tumor and the cervical lymphatic drain received a radiation dose of 56 Gy (2 Gy/ treatment, 5 fractions a week). Patients with R0 resections received doses from 56 to 60 Gy. Patients with close resections margins received a higher dose of 60 to 66 Gy at the tumorbed and patients with R1 resections were treated with a boost up to 66 to 70 Gy. Patients with UICC 4 status with an increased recurrency risk received an additional chemotherapy with cisplatin (40mg/m"2 a week) in 1 to 4 cycles as well a boost of the tumorbed up to 66 to 70 Gy. In the univariate analysis with the Kaplan-Maier Plat method following factors of influence were detected: tumor status (p-value 0,003), lymph node status (p-value 0,048), chemotherapy (p-value 0,047), second tumor (p-value 0,003) and the overall tumor volume (p-value 0,000). Results of the multivariate analysis In the Cox regression analysis the tumor status and the development of a second tumor were detected as factors of influence of the 5 year overall survival rate and the 5 year disease free survival survival rate. Regarding to the overall survival rate for the tumor status was detected a statistical significance of 0,015 and regarding the disease free survival was detected a significance of 0,025. The factor of influence of the second tumor had a significance for the overall survival of 0,015 and a significance regarding the disease free survival of 0,025. Conclusion: With the concept of medical treatment there could be achieved an improvement of the 5 year overall survival and the 5 year disease free survival. Patients with close resection margins had throughout better results as patients with a R0 resection. The consequence of those results should be an adjustment of the present concept of medical treatment of the R0 patients to the concept of patients with close resection margins. Patients who received a simultaneous radiochemotherapy, because of the increased risk of recurrence, the present concept of medical treatment effected an adjustment of the 5 year overall survival rate to patients without an increased risk of recurrence. There was no statistical significance in the multivariate analysis at the overall survival as well as at the disease free survival (overall survival p-value 0,064, disease free survival p-value 0,085).

  19. Neues Punktionsinstrumentarium: Provox-Vega®-Punktionsset: Anwendung beim Einbringen einer Stimmprothese nach Laryngektomie

    NARCIS (Netherlands)

    Lorenz, K.J.; Hilgers, F.M.; Maier, H.

    2013-01-01

    Background The use of voice prostheses has been considered the gold standard in voice rehabilitation following laryngectomy for the last 20 years. Insertion is generally performed as a primary procedure during laryngectomy or as a secondary procedure with a re-usable trocar or rigid esophagoscope, a

  20. Application of soil data in climate research; Anwendung von Bodendaten in der Klimaforschung

    Energy Technology Data Exchange (ETDEWEB)

    Kaufmann-Boll, Carolin; Kappler, Wolfgang; Lazar, Silvia [ahu AG Wasser - Boden - Geomatik, Aachen (DE)

    2011-10-15

    The German Strategy for Adaptation to Climate Change was adopted in 2008. The implementation of the strategy requires reliable data and time series on the long-term changes in soil condition and soil functions. Soil monitoring and soil survey are essential data bases for this purpose. In Germany there are permanently established monitoring programmes with representative locations and repeated soil surveys based on a regular grid of sites. The different programmes vary in respect to harmonization regarding agreed principles between the participating institutions. Information on soil measuring data is currently heterogeneous and distributed at many locations. Particularly the provision of (meta-)data should be improved. Here you can find the exceptional quality of BOKLIM. It evaluates the suitability of soil data for climate research across the different measuring programmes in Germany. The most important nation-wide and permanently operating programmes of soil monitoring and soil survey were taken into account. The main aspects were the changes in soil condition due to climate change. As a result, the programmes provide a variety of valuable data to assess the effects of climate change on soils. Depending on the problem and the resulting requirements, the data are suitable (1) for the long-term monitoring of changes in soil condition, (2) for detailed process studies and measurements at representative locations, e.g. for the calibration and validation of predictive models, and (3) for use in model scenarios predicting changes in soil condition. However, it is necessary to coordinate the programmes of soil monitoring and soil survey with the focus on precise questions. The programmes have to be optimized at certain points to improve for issues of climate change and adaptation. In addition to the evaluation of soil data, a first concept for an efficient data provision and data use was created. Recommendations for next steps to coordinate and optimize future monitoring and survey activities and for data provision are advised to the relevant competent institutions and actors. Further research needs were identified. The recommendations aim at improving the interaction between climate change and soil conditions. They can also be taken up for other research fields such as soil protection aspects or biodiversity strategy aspects. (orig.)

  1. Diffusion imaging: technology and clinical application; Diffusionsbildgebung. Technik und klinische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Kukuk, Guido Matthias; Greschus, Susanne; Pieper, Claus Christian [Universitaetsklinik Bonn (Germany). Radiologische Klinik; Goldstein, Jan [Staedtisches Klinikum Solingen (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie

    2017-03-15

    While diffusion imaging was predominantly used for cerebral ischemia diagnostics it is now a widely applied MR diagnostic tool for oncologic or inflammatory diseases. The contribution is focused on the fundamentals of diffusion imaging and the most important indications.

  2. Mesostrukturierung und chemische Modifikation von Kathodenmaterialien zur Anwendung in Lithium-Schwefel Batterien

    OpenAIRE

    Schneider, Artur

    2016-01-01

    Die vorliegende Dissertation beschäftigt sich mit der Strukturierung und Charakterisierung von Kohlenstoffmaterialien, ihrer chemischen Modifikation, sowie deren Einsatz als Kathodenmaterialien in Lithium-Schwefel Batterien.

  3. Ein Vorschlag zur Wahl der Zuchtwerte bei der Anwendung dermarkergestützten Selektion

    DEFF Research Database (Denmark)

    Thomsen, Hauke

    2009-01-01

    Im Rahmen dieser Simulationsstudie wurde ein Enkelinnendesign mit 10 Großvätern erstellt, um die Einflüsse unterschiedlicher Eingabevariablen in der markergestützten Selektion zu untersuchen. Dabei wurden genotypische und phänotypische Daten für die Großväter, Großmütter und 500 Söhne simuliert. ......,89), so dass empfohlen wird diese Eingabevariable in der markergestützten Zuchtwertschätzung zu verwenden...

  4. Application of soil data on adaptation of climate; Anwendung von Bodendaten bei der Klimaanpassung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-05-15

    Within the workshop of the Federal Environment Agency (Dessau-Rosslau, Federal Republic of Germany) at 20th to 30th September, 2009 in Dessau (Federal Republic of Germany), the following lectures were held: (1) Action plan adaptation - Adaptation measures and their verifiability on the basis of soil data (K. Mattern); (2) Legal background of the provision of metadata (H. Ginzky); (3) Which soil data are necessary? Requirements of Evaluation of the impact of climatic change and adaptation (W. Eckelmann); (4) Which soil data are present? Chances, deficits and recommendations for action (C. Kaufmann); (5) Instruments for providing metadata (W. Kappler); (6) Project TERENO - Soil atmosphere interactions induced by land use changes as a result of global change (H. Bogena, T. Puetz, H. Vereecken); (7) Further development and implementation of an European forest monitoring sysem (O. Granke); (8) Survey of the state of soil in agriculture and forestry (S. Schobel, C. Siebner); (9) Requirements on soil data from the view of the European Community (L. Montanarella); (10) Resume, view into the future, experiences with the market (F. Makeschin, H.G. Meiners, J. Mathews).

  5. Darstellung und Anwendung eines Bewertungsmodells im Rahmen des Controllings unter Beachtung der IAS/IFRS

    OpenAIRE

    Volkmann, Sebastian

    2005-01-01

    Die zunehmende Etablierung des Shareholder Value-Gedankens in Europa, die Rechnungslegung nach IAS/IFRS in Kombination mit der Forderung nach Konvergenz des internen sowie des externen Rechnungswesens erfordern die vertiefte Kapitalmarktorientierung von Unternehmen. Entsprechend werden in dieser Arbeit Ansätze diskutiert, die wertorientierte Unternehmensführung mit Hilfe eines Bewertungsmodells zu unterstützen, um Implementierungslücken auf Ebene des Konzern- oder Geschäftsbereichscontrolling...

  6. Mobile high-voltage switchboard. Variable and uncomplicated; Mobile Hochspannungsschaltanlage. Variabel und unkompliziert in der Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Albert, Andreas [Siemens AG, Erlangen (Germany). Sector Energy

    2009-07-13

    The mobile high-voltage switchboard ''REE-Movil 2'' for voltages up to 245 kV provides a complete and nearly autonomous switchboard in a container, a solution that has been available in the medium-voltage sector for some time already. It can be used whenever a quick replacement of a switchboard section or a temporary supplement to a switching substation is needed. The container is mounted on a trailer for maximum flexibility and mobility. (orig.)

  7. Computer-tomography and its use in failure analysis; Computertomographie und deren Anwendung in der Schadensanalytik

    Energy Technology Data Exchange (ETDEWEB)

    Panzenboeck, Michael; Freitag, Caroline [Montanuniv. Leoben (Austria). Dept. Metallkunde und Werkstoffpruefung; Borchert, Marlies [Materials Center Leoben (Austria)

    2017-04-15

    In the last fifteen years computer-tomography has proven to be a valuable aid in the fields of medicine, materials technology and forensics. Nowadays it is hard to image non-destructive testing being carried out without its use. This article serves to demonstrate the power of the technique within the field of failure analysis with reference to two chosen case studies. The first case concerns the failure of magnetic valves, the second case focusses on the failure of corrosion resistant screws.

  8. Application of thermodynamic data from THEREDA with THROUHREACT; Anwendung thermodynamischer Daten aus THEREDA mit TOUGHREACT

    Energy Technology Data Exchange (ETDEWEB)

    Seher, Holger; Weyand, Torben; Bracke, Guido

    2017-02-15

    Codes from the TOUGH family are used by GRS for many issues of the final radioactive waste disposal. For geochemical modeling in highly saline solutions the project THEREDA offers qualified thermodynamic data sets with Pitzer parameters that can be used as input data for specific systems and geochemical codes. For the application of thermodynamic data base from THEREDA in model calculations with THROUGHREACT a tool for the reformatting of the data sets was developed. THROUGHREACT will be used in the future for modeling of reactive transport in final radioactive waste repositories including complex processes.

  9. Hydrogen - more than just a mobile application; Wasserstoff - mehr als nur eine mobile Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Pitschak, Bernd [Hydrogenics GmbH, Gladbeck (Germany)

    2013-03-15

    The securing of a reliable, economical and environmentally friendly energy supply is one of the greatest challenges of the 21st century. Using the energy concept, the Federal Government formulates guidelines for such an energy supply and describes for the first time the way for the age of renewable energy. It is all about the development and implementation of an overall long-term strategy for the time period up to 2050.

  10. Beeinflussung des Angebots im Lebensmitteleinzelhandel durch Konsumenteninformationen: Eine Anwendung auf Basis der Theory of Planned Behavior

    OpenAIRE

    Mecking, Rebecca-Ariane

    2015-01-01

    Von Informationen, die Konsumenten z. B. über Kundenkarten dem Lebensmitteleinzelhandel (LEH) mitteilen, können auch sie selber profitieren, indem das Angebot besser an ihre Bedürfnisse angepasst wird. Basierend auf der Theory of Planned Behavior untersucht diese Arbeit, welche Faktoren entscheidend dafür sind, ob ein Konsument dem LEH zum Zwecke der Einflussnahme Informationen mitteilen möchte. Wichtig sind das Bewusstsein um diese Chance und ihre positiven Folgen. Sorgen um die Privatsphäre...

  11. Eine praktische Anwendung von CMC-Flächen in der Bionik

    OpenAIRE

    Apeltauer, Christian

    2011-01-01

    Die vorliegende Arbeit beschäftigt sich mit den theoretischen Grundlagen für die Entwicklung von Oberflächen, die unter Wasser möglichst lange eine Luftschicht an sich halten können. Ein natürliches Vorbild für solche Oberflächen ist die Pflanze Salvinia molesta; technisch interessieren solche Oberflächen zur Verringerung des Wasserwiderstandes von Schiffen und als Schutz vor Besiedlung durch Wasserorganismen. Wichtigste Gleichung bei der Entwicklung solcher Oberflächen ist...

  12. Cutting with laser beams and water jets. Schneiden mit Laserstrahlung und Wasserstrahl; Anwendung, Erfahrungen, Ausblick

    Energy Technology Data Exchange (ETDEWEB)

    Engemann, B.K.; Herbrich, H.; Kessler, B.; Langemann, M.

    1993-01-01

    Cutting with laser beams and water jets left the laboratory stage about 20 years ago and has been used commercially in the last few years to an increasing extent. Both techniques offer a fast and low-cost option for producing materials and components that cannot, or only with difficulty, be worked with mechanical separation methods. The book discusses: Equipment and systems for beam generation; control systems and auxiliary systems; process fundamentals and parameters; applications. The book attempts a comprehensive review of the fields of application of both systems as well as a list of the systems now available on the market. (orig./RHM). 131 figs.

  13. Anwendung der isothermalen Mikrokalorimetrie zur physikochemischen Charakterisierung molekularer Interaktionen in pharmazeutischen Formulierungen

    OpenAIRE

    Schicke, Burkhard Christoph

    2010-01-01

    Die isothermalen Mikrokalorimetrie (IMC) ermöglicht die Erfassung von Wärmeflüssen im Mikrowattbereich. Der Nutzen und die Aussagekraft dieser Methode wurden bei folgenden physikochemischen Prozessen untersucht: Hydratation von Diclofenac-Natrium (DfNa) zum Tetrahydrat bei verschiedenen Temperaturen und relativen Feuchten, Kompatibilitäts¬untersuchungen von DfNa und amphiphiler Stärke bei 100% rH und Temperaturen bis zu 313 K, Kristallisationsverhalten von unterschiedlichen Triglycerid-Phosph...

  14. Anwendung von kathodischen Korrosionsschutzmaßnahmen bei 30 Spannbetonbrücken in den Niederlanden

    NARCIS (Netherlands)

    Hondel, H. van den; Klamer, E.L.; Gulikers, J.; Polder, R.B.

    2015-01-01

    Die oberste niederländische Straßen- und Wasserbaubehörde (Rijkswaterstaat) hat im Hinblick auf die langfristige Instandhaltung ihrer Infrastruktureinrichtungen über 1500 Endverankerungsbereiche von Spannbetonbrückenträgern instandgesetzt und einer kathodischen Korrosionsschutzbehandlung (KKS)

  15. Konsensus zur Anwendung der "Tension-free Vaginal Tape" (TVT Operation bei der weiblichen Belastungsinkontinenz

    Directory of Open Access Journals (Sweden)

    Hanzal E

    2003-01-01

    Full Text Available Unter der Patronanz der Medizinischen Gesellschaft für Inkontinenzhilfe Österreich wurde im Juni 2002 in Wien die 2. Auflage eines Österreichischen Tension-free Vaginal Tape (TVT Konsensus-Meetings abgehalten. TVT ist eine neue Operationstechnik zur Behandlung der weiblichen Stressharninkontinenz, die seit 1998 in Österreich eingesetzt wird. Im Rahmen des Treffens, an dem Experten aus den Fachbereichen Urologie und Gynäkologie teilnahmen, wurde die vorhandene Fachliteratur analysiert und ein Konsensus für die präoperative Abklärung, Durchführung und postoperative Verlaufskontrolle als Basis für eine laufende Qualitätsverbesserung des Verfahrens erarbeitet, dessen Ergebnis in dem vorliegenden Papier als Leitlinie zusammengefaßt ist.

  16. Application of diffusion tensor imaging in neurosurgery; Anwendung der Diffusions-Tensor-Bildgebung in der Neurochirurgie

    Energy Technology Data Exchange (ETDEWEB)

    Saur, R. [Sektion fuer Experimentelle Kernspinresonanz des ZNS, Abt. Neuroradiologie, Universitaetsklinikum Tuebingen (Germany); Augenklinik des Universitaetsklinikums Tuebingen (Germany); Klinik fuer Psychiatrie und Psychotherapie des Universitaetsklinikums Tuebingen (Germany); Gharabaghi, A. [Klinik fuer Neurochirurgie des Universitaetsklinikums Tuebingen (Germany); Erb, M. [Sektion fuer Experimentelle Kernspinresonanz des ZNS, Abt. Neuroradiologie, Universitaetsklinikum Tuebingen (Germany)

    2007-07-01

    Knowledge about integrity and location of fibre tracts arising from eloquent cortical areas is important to plan neurosurgical interventions and to allow maximization of resection of pathological tissue while preserving vital white matter tracts. Diffusion Tensor Imaging (DTI) is so far the only method to get preoperatively an impression of the individual complexity of nerve bundles. Thereby nerve fibres are not mapped directly. They are derived indirectly by analysis of the directional distribution of diffusion of water molecules which is influenced mainly by large fibre tracts. From acquisition to reconstruction and visualisation of the fibre tracts many representational stages and working steps have to be passed. Exact knowledge about problems of Diffusion Imaging is important for interpretation of the results. Particularly, brain tumor edema, intraoperative brain shift, MR-artefacts and limitations of the mathematical models and algorithms challenge DTI-developers and applicants. (orig.)

  17. Entwicklung und Anwendung von Methoden zur Bestimmung von Selen-Spezies in human-biologischem Material

    OpenAIRE

    Jäger, Thomas

    2014-01-01

    Selen ist essentieller Bestandteil von mehr als 25 physiologisch wichtigen menschlichen Enzymen. Der tägliche Bedarf wird überwiegend in Form von organischen Selenverbindungen wie Selenmethionin oder Selenocystein aus der Nahrung aufgenommen. Weitere Expositionswege sind die Einnahme von Nahrungsergänzungsmitteln zur Selensupplementation sowie die inhalative oder dermale Aufnahme von in erster Linie anorganischen Selenverbindungen oder elementarem Selen an Arbeitsplätzen der Selen-verarbeiten...

  18. From clay bricks to deep underground storage; vom lehmziegel bis zum tiefenlager -- anwendung von ton

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-05-15

    This booklet issued by the Swiss National Cooperative for the Disposal of Radioactive Waste NAGRA takes a look at the use of clay strata for the storage of radioactive wastes in deep-lying repositories. First of all, a geological foray is made concerning the history of the use of clay and its multifarious uses. The characteristics of clay and its composition are examined and its formation in the geological past is explained. In particular Opalinus clay is looked at and the structures to be found are discussed. The clay's various properties and industrial uses are examined and its sealing properties are examined. Also, Bentonite clay is mentioned and work done by Nagra and co-researchers is noted.

  19. Vom "Deficit Accounting" zum "Generational Accounting ": Eine Anwendung für die Schweiz

    OpenAIRE

    Stefan Felder

    1997-01-01

    The stance of fiscal policy is commonly assessed by the size of the annual budget deficit and public debt. Both indices fail, however, to correctly reflect the long run financial burden of government programs such as social security. An alternative to "deficit accounting" is "generational accounting" which in particular reveals the intergenerational distribution effect of government legislation. The present paper applies generational accounting on the pay-as-you-go financed part of old age pe...

  20. Fundamentals of ecology. Vol. 2. Grundlagen der Oekologie. Bd. 2. Standorte und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Odum, E P

    1980-01-01

    The following topics are discussed: freshwater flora and fauna; marine ecosystems; shelf, krill, mangroves, and coral reefs; terrestrial biota and biogeographic regions; deciduous wood, grassland, desert; microbial-ecological perspectives: taxonomy, efficiency, turnover; aquaculture, agriculture, forestry; types, cost, and phases of environmental pollution; specific population ecology of humans.

  1. Side effects of radiotherapy in breast cancer patients. The Internet as an information source

    Energy Technology Data Exchange (ETDEWEB)

    Janssen, S. [Medical Practice for Radiotherapy and Radiation Oncology, Hannover (Germany); University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); Kaesmann, L.; Rades, D. [University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); Fahlbusch, F.B. [Friedrich-Alexander-University of Erlangen-Nuernberg, Department of Pediatrics and Adolescent Medicine, Erlangen (Germany); Vordermark, D. [University Hospital Halle (Saale), Department of Radiation Oncology, Halle (Saale) (Germany)

    2018-02-15

    ] Brustkrebs ist der haeufigste Tumor bei Frauen, der eine adjuvante Strahlentherapie notwendig macht. Da das Internet eine wesentliche Informationsquelle fuer Krebspatienten geworden ist, hat diese Untersuchung das Ziel, die Qualitaet der Webseiten mit Informationen zu Nebenwirkungen einer Strahlentherapie bei Brustkrebs zu evaluieren. Mit Hilfe der Suchmaschine Google wurde eine patientenorientierte Suche englisch- und deutschsprachiger Webseiten mit den Suchbegriffen ''Brustkrebs-Strahlentherapie - Nebenwirkungen'' und ''Breast cancer - radiotherapy - side effects'' an zwei verschiedenen Zeitpunkten durchgefuehrt. Die ersten 30 Treffer wurden anhand des validierten 16-Fragen DISCERN-Plus-Scores, der HON-Code-Zertifizierung (''Health on the Net Code of Conduct'') und den JAMA-Kriterien (''Journal of the American Medical Association'') untersucht. Die Gesamtqualitaet der untersuchten Seiten (DISCERN-Score) wurde im Weiteren mit einer separaten Analyse der Suchmaschinen Bing und Yahoo verglichen. Waehrend die allgemeine Qualitaet der Internetseiten (DISCERN-Score) eine grosse Bandbreite zeigte, waren die Ergebnisse mehrheitlich von maessiger bis schlechter Qualitaet. Englischsprachige Webseiten zeigten signifikant bessere Ergebnisse, insbesondere Seiten von Krankenhaeusern, Universitaeten sowie Nicht-Regierungs-Organisationen. Nur eine Minderheit erfuellte alle 4 JAMA-Kriterien und war HON-Code-zertifiziert (beide Sprachen). Die Google-Suche zu unterschiedlichen Zeitpunkten zeigte unter den ersten zehn Treffern keine wesentlichen Unterschiede. Signifikante Variationen traten erst bei hinteren Treffern auf. Der Vergleich unterschiedlicher Suchmaschinen ergab aehnliche DISCERN-Score-Ergebnisse. Durch das Internet koennen sich Patienten auf der Suche nach Informationen zur Strahlentherapie einen Ueberblick verschaffen. Basierend auf der aktuell geringen Qualitaet der Internetseiten und der fehlenden

  2. Effects of radiotherapy in the treatment of multiple myeloma; Stellenwert der Strahlentherapie und deren Nebenwirkungen bei der Behandlung von Patienten mit Multiplem Myelom

    Energy Technology Data Exchange (ETDEWEB)

    Ochtrop, Thomas Alexander

    2015-07-01

    Palliative irradiation of osteolytic lesions is a considerable component in the treatment for patients with multiple myeloma. In this study, we analyzed the efficacy of irradiation in these patients. Patients and methods: We retrospectively analyzed 153 patients with multiple myeloma who were admitted to our department between 1989 and 2013. According to the staging system of Durie and Salmon 116 patients were classified as stage III. 107/153 patients were treated with radiotherapy of at least one and up to 6 bony lesions at different times. In order to evaluate the effect of local radiotherapy on pain relief and bone recalcification a uni- and multivariate analysis was performed using a binary logistic regression model to correct for multiple measurements. Complete information on dose, fractionation and volume of radiotherapy was available from 81 patients treated in 136 target volumes for pain relief, and from 69 patients treated in 108 target volumes for recalcification. Total radiation doses varied between 8 Gy to 50 Gy (median dose 25 Gy in 2.5 Gy fractions, 5 times a week). Results: Radiotherapy resulted in complete local pain relief in 31% and partial local pain relief in 54% of the patients. In the univariate analysis, higher total radiation doses (p = 0.023) and higher age (p = 0.014) at the time of radiotherapy were significantly associated with a higher likelihood of pain relief, whereas no significant association was detected for concurrent systemic treatment, type and stage of myeloma and location of bone lesions. The same variables were independent predictors for pain relief in the multivariate analysis. Recalcification was observed in 48% of irradiated bone lesions. In the uni- and multivariate analysis higher radiation doses were significantly associated (p = 0.048) with an increased likelihood of recalcification. Side effects of radiotherapy were generally mild. Conclusions: Higher total biological radiation doses were associated with better pain relief and recalcification in this retrospective evaluation of multiple myeloma patients. In addition, in the elderly the therapeutic measures appear to develop a better analgesic effect.

  3. Radiation therapy in patients with cardiac pacemakers or implantable cardioverter defibrillators. Interdisciplinary safety recommendations; Strahlentherapie bei Patienten mit Herzschrittmachern oder implantierbaren Kardioverter-Defibrillatoren. Interdisziplinaere Sicherheitsempfehlungen

    Energy Technology Data Exchange (ETDEWEB)

    Dorenkamp, M.; Haverkmap, W.; Roser, M. [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum (Germany). Medizinische Klinik mit Schwerpunkt Kardiologie; Stromberger, C.; Wust, P. [Charite Universitaetsmedizin Berlin (Germany). Klinik fuer Radioonkologie und Strahlentherapie; Heymann, C. von [Charite Universitaetsmedizin Berlin, Campus Virchow-Klinikum (Germany). Klinik fuer Anaesthesiologie mit Schwerpunkt operative Intensivmedizin

    2013-01-15

    Background: With increasing numbers of implanted pacemakers and implantable cardioverter defibrillators (ICD) and a rising incidence of malignant tumors, there is a growing probability of radiation-mediated device dysfunction. The only guidelines for the management of patients with cardiac pacemakers in the case of radiation therapy were published in 1994 and have not been updated since then. Based on the current evidence and modern device technology, the present paper aims to develop contemporary and interdisciplinary safety recommendations for the minimization of patient risk. Methods and results: A systematic literature research was carried out including the most relevant medical electronic databases. The search yielded 147 articles published between 1994 and 2012 of which 45 met the selection criteria and of these studies 34 presented primary data (9 in vitro and 25 in vivo studies). The impact of ionizing radiation varied significantly between implanted devices and ranged from no functional changes to complete loss of function. Important device dysfunctions included changes in sensing capability, altered pacing pulses or rate, changed or disabled tachyarrhythmia ICD therapies, early battery depletion and loss of telemetry. Modern pacemakers and ICDs are more sensitive to radiation than older models. Potentially life-threatening complications were observed after exposure of the pulse generator to comparatively low radiation doses (0.11 Gy). Conclusions: Practical recommendations for patient management and safety are presented that can be readily adopted by any institution carrying out radiation therapy. (orig.)

  4. Radiotherapy for treatment of bursitis. Indication, technique, own results, literature survey; Strahlentherapie bei der Periarthropathia humeroscapularis (PHS). Indikation, Technik, eigene Ergebnisse, Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Heyd, R. [Staedtische Kliniken Offenbach am Main (Germany). Strahlenklinik]|[Frankfurt Univ. (Germany). Klinik fuer Strahlentherapie und Onkologie; Schopohl, B.; Boettcher, H.D. [Frankfurt Univ. (Germany). Klinik fuer Strahlentherapie und Onkologie

    1998-12-31

    Our own experience covers 41 primarily chronic cases. The patients have been irradiated with a telecobalt device with isocentric opposing fields, receiving 4x1.0 Gy within two weeks; 15 patients (36.6%) received a second radiation treatment (8 Gy), and one patient (2.4%) a third (12 Gy). After a follow-up period of 44 months on the average, the results were: Complete remittence of pain in 44%, abatement of pain in 44%, and no effect in 12%. Improvement of shoulder joint motility was achieved in 78%. The rate of recidivation was as low as 3%. A statistical evaluation of data acquired revealed that the prognosis is worst in case of a long period of pain preceding commencement of radiotherapy, combined with intensive prior therapy. (orig./CB) [Deutsch] In einer eigenen Untersuchung wurden 41 ueberwiegend chronische Faelle mit 4x1,0 Gy in 2 Wochen an einem Telekobaltgeraet mit isozentrischen Gegenfeldern behandelt, 15 (36,6%) erhielten eine 2. Bestrahlungsserie (8 Gy), ein Fall (2,4%) eine Dritte (12 Gy). Nach einem Nachbeobachtungszeitraum von median 44 Monaten fand sich bei 44% eine komplette Schmerzremission, bei 44% eine Linderung und 12% waren ohne einen Einfluss der Behandlung. Eine Verbesserung der Motilitaet des Schultergelenkes wurde bei 78% erreicht. Die Rezidivrate lag bei nur 3%. Nach statistischer Bearbeitung der Daten erwies sich die Kombination einer langen Beschwerdedauer vor Einleitung der Radiotherapie und intensiver Vortherapie als prognostisch unguenstiger (p=0,02). (orig.)

  5. Transcriptome-wide studies of prostate cancer cell lines in the context of medical radiation; Transkriptomweite Untersuchungen von Prostata-Krebszelllinien im Kontext medizinischer Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, Paul

    2012-06-26

    The use of radiotherapy in addition to chemotherapy and surgical removal is the most powerful instrument in the fight against malignant tumors in cancer medicine. After cardiovascular diseases, cancer is the second leading cause of death in the western world, in which prostate cancer is the most frequent male cancer. Despite continuous technological improvements in radiological instruments and prognosis, it may occur a recurrence up to many years after radiotherapy due to a high resistance capability of individual malignant cells of the locally occurring tumor. Although modern radiation biology has studied many aspects of the resistance mechanisms, questions are largely unanswered especially in regards to prognostic terms and time response of tumor cells to ionizing radiation. As cellular models four prostate cancer cell lines with different radiation sensitivities (PC3, DuCaP, DU-145, RWPE-1) were cultured and tested for their ability to survive after exposure to ionizing radiation by a trypane blue and MTT viability assay. The proliferative capacity of the four cell lines was determined using a colony formation assay. The PC3 cell line (radiation-resistant) and the DuCaP cell line (radiation-sensitive) showed the maximal differences in terms of radiation sensitivity. Based on these results the two cell lines were selected to allow identification of potential prognostic marker for predicting the effectiveness of radiation therapy via their transcriptome-wide gene expression. Furthermore, a time series experiment with the radiation-resistant PC3 cell line was performed. At 8 different time points, during the period from 00:00 - 42:53 (hh:mm) after exposure with 1 Gy, the mRNA was quantified by next generation sequencing to investigate the dynamic behavior of time-delayed gene expression and to discover resistance mechanisms. Of 10,966 expressed genes 730 were significant differentially expressed, determined by setting a fold change threshold in conjunction with a P-value < 0.01. Of those 305 were more strongly expressed in PC3 cell line and 425 were more strongly expressed in the DuCaP cell line. Within these 730 genes many known stress-associated genes could be found, such as the two trans-membrane protein genes CA9 and CA12, which are associated with increased radiation resistance. By calculating a network score interesting networks were derived by the GO and KEGG databases. In particular the GO categories aldehyde dehydrogenase [NAD(P)+] activity (GO:0004030) as well as the KEGG pathway of O-glycan biosynthesis (hsa00512) seems to be remarkably relevant. An interaction analysis revealed two promising networks with the transcription factors JUN and FOS as central elements. High expression of the JUN network would be stand as indicator for radiation resistance whereas a high expression of the FOS network is equated with radiation sensitivity. Interesting insights could be achieved by analyzing the 10,840 expressed genes of the PC3 cell line and its expression profile over the 8 time points. Shortly after irradiation (00:00 - 00:30) a transcriptome-wide down-regulation occurred, within the next three, short time periods (00:30 - 01:03; 01:03 - 02:12; 02:12 - 04:38) a predominant increase of gene expression and the activation of protective networks followed, such as the up-regulation of DNA repair systems or the arresting of cell cycle. In the ensuing three time periods (4:38 - 09:43; 09:43 - 20:25; 20:25 - 42:35) a balance between gene induction and suppression was present and the absolute gene expression change was increased. When comparing the gene expression prior to irradiation with the last time point (00:00 - 42:53) 2,670 genes were differentially expressed, suggesting a massive and system-wide change of gene expression. Signaling pathways such as the ATM-regulated cell cycle and apoptosis, the Nrf2 pathway after oxidative stress exposure, the DNA repair mechanisms of homologous recombination, the non-homologous end joining, the mismatch repair, base-excision repair and strand-excision repair play a major role. Very interesting are the high activity of RNA-driven events, especially activities of small nucleolar RNAs and pseudouridine processes. This suggests that these RNA-modifying networks could have a hitherto unknown functional and protective effect on cell survival after exposure to ionizing radiation. All these protective networks and their time-specific interactions are essential for the survival of cells after exposure to oxidative stress and show a complex but consistent interaction of many individual components to a system-wide running program.

  6. Pain and quality of life following palliative radiotherapy of bone metastases; Der Einfluss palliativer Strahlentherapie auf Schmerz und Lebensqualitaet bei Patienten mit Knochenmetastasen

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, N.; Wild, B.; Henningsen, P.; Jakobsen, T. [Klinik fuer Psychosomatische und Allgemeine Klinische Medizin, Univ. Heidelberg (Germany); Leising, D. [Inst. fuer Psychologie, Univ. Wuerzburg (Germany); Treiber, M. [Radiologische Universitaetsklinik, Heidelberg (Germany)

    2006-09-15

    Pain and quality of life following palliative radiotherapy of bone metastases Background and purpose: palliative irradiation is used to provide pain relief and to increase quality of life. Most studies exclude patients with advanced cancer disease and, therefore, a positive selection results. This prospective clinical study investigates the effect of palliative radiotherapy on pain and quality of life of patients with painful bone metastases. Patients and methods: 263 patients with bone metastases due to advanced cancer were observed with respect to pain and quality of life during a 2-month course of radiotherapy. Missing data were substituted by the LOCF method (last observation carried forward) to prevent a biased reduction of data. Results: radiotherapy resulted in pain relief. In the complete group, pain medication was not increased. Quality of life was not affected positively. Side effects of radiotherapy increased remarkably. Conclusion: Radiotherapy leads to pain relief. However, risks and benefits must be considered critically due to side effects. (orig.)

  7. Radiation therapy of hyperplastic heterotopic ossifications in osteogenesis imperfecta; Two case reports. Strahlentherapie hyperplastischer heterotoper Ossifikationen bei Osteogenesis imperfecta; Zwei Falldarstellungen

    Energy Technology Data Exchange (ETDEWEB)

    Micke, O. (Muenster Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie - Radioonkologie); Wagner, W. (Muenster Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie - Radioonkologie); Poetter, R. (Allgemeines Krankenhaus der Stadt Wien, Vienna (Austria). Universitaetsklinik fuer Strahlentherapie und Strahlenbiologie); Prott, F.J. (Muenster Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie - Radioonkologie); Karbowski, A. (Muenster Univ. (Germany). Klinik und Poliklinik fuer Allgemeine Orthopaedie)

    1994-06-01

    Purpose: Osteogenesis imperfecta is a rare hereditary disease of connective tissue with a genetic defect in collagen synthesis. In osteogenesis imperfecta hyperplastic heterotopic ossification can be induced by hyperplastic callus formation caused by trauma or operation. Heterotopic ossifications can be found in numerous benign diseases. The successful use of low dose radiotherapy in the treatment of heterotopic ossifications in well-known from the literature. Patients and Methods: We treated two children (a 13-year old girl and a ten-year old boy) with heterotopic ossifications of the lower extremities in osteogenesis imperfecta type IV (Lobstein) with a low dose irradiation (10x1 Gy, respectively 6x1 Gy) under megavoltage conditions. Results: After radiotherapy the children were painfree and the hyperplastic callus was considerably reduced. The previously immobilized patients could partly be mobilized. Thereby it could be contributed to the rehabilitation of the patients. New hyperplastic callus formation was not observed in the irradiated areas so far. Conclusion: Analogous to the successful radiation of heterotopic ossifications in other benign diseases radiation therapy seems to be a successful treatment of hyperplastic callus formation in osteogenesis imperfecta. Despite the late risks of radiotherapy radiation treatment of benign diseases in children might be indicated. (orig.)

  8. Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or chemoradiotherapy. Therapieergebniss, Frueh- und Spaettoxizitaet der Behandlung des Analkanalkarzinoms durch Strahlentherapie oder Chemoradiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Sommer, K.; Brockmann, W.P.; Wiegel, T.; Kruell, A.; Huebener, K.H.; Birk, S. (Universitaetskrankenhaus Eppendorf, Hamburg (Germany). Abt. fuer Strahlentherapie)

    1991-08-01

    From 1975 to 1989 114 patients with analcanal carcinoma were treated, 81 of these with radiotherapy (RT) alone and 33 with chemoradiotherapy (CRT). 80% respectively 82% of the patients were colostomy-free at the onset of therapy. RT was given to a total dose of 60 Gy in six weeks, for CRT additional simultaneous 5-fluorouracil (500 mg/m{sup 2} days 1 to 5 and 8 to 12) and mitomycin C (5 mg/m{sup 2} days 5 and 12) was administered. 67% respectively 82% of the patients had UICC stage II to IIIB disease predominantly with G2 and G3 squamous cell carcinomas. Local control after three years was 79% for the RT group vs. 82% for the CRT group. Three-year survival rate was 68% and 71%, respectively. These differences were not signficant. Only for G1-compared to G3-tumors there is a significantly higher survival rate. Acute and late damage was slightly lower for the RT treatment group (77% and 25%) compared to the CRT group (79% and 30%). In both treatment groups there was one patient needing a permanent colostomy due to radiation induced proctitis. In conclusion, RT or CRT should be the primary form of treatment in patients with anal canal carcinoma and abdominoperineal resection should only be performed in case of local recurrence or tumor persitence. The final decision about the indications for RT or CRT can only be made with the results of a prospective randomized trial. (orig.).

  9. Radiotherapy in painful gonarthrosis. Results of a national patterns-of-care study; Strahlentherapie bei schmerzhafter Kniegelenkarthrose (Gonarthrose). Ergebnisse einer deutschen Patterns-of-Care-Studie

    Energy Technology Data Exchange (ETDEWEB)

    Muecke, Ralph; Schaefer, Ulrich [Klinik fuer Strahlentherapie, Klinikum Lippe-Lemgo (Germany); Seegenschmiedt, M. Heinrich [Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin, Alfried Krupp Krankenhaus, Essen (Germany); Heyd, Reinhard [Strahlenklinik, Klinikum Offenbach GmbH (Germany); Prott, Franz-Josef [GMP fuer Radiologie und Strahlentherapie am St. Josefs-Hospital, Wiesbaden (Germany); Glatzel, Michael [Klinik fuer Strahlentherapie und Radioonkologie, Klinikum Suhl (Germany); Micke, Oliver [Klinik fuer Strahlentherapie und Radioonkologie, Franziskus Hospital, Bielefeld (Germany)

    2010-01-15

    Backgroud and Purpose: After a patterns-of-care study (PCS) in 2003/2004 addressing benign disorders in general, the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD) conducted several multicenter cohort studies including the use of radiotherapy (RT) in painful gonarthrosis (GNA). Material and Methods: From 2006 to 2008, a PCS for GNA was conducted in all German RT institutions using a standardized structured questionnaire. Patient accrual, patient number, pretreatment, pain record, treatment indications, RT technique, and target volume concepts for painful GNA were assessed. In addition, the long-term functional and subjective outcomes were evaluated. Results: 238/248 institutions (95.9%) returned the questionnaire: 50 (21%) reported no clinical experience with RT in GNA, while 188 (79%) institutions treated 4,544 patients annually (median 15; range one to 846 cases per institution). Indications for treatment were acute pain symptoms in 18.9%, chronic pain in 95.3%, and treatment-refractory pain in 81.1%. The median total dose was 6 Gy (range 3-12 Gy), with a median single dose of 1 Gy (0.25-3 Gy). 40.4% of the institutions applied two fractions and 51.4% three fractions weekly. RT was delivered with orthovoltage units (25%), linear accelerators (79.6%), and cobalt-60 units (8.3%). 42 institutions evaluated the long-term clinical outcome in a total of 5,069 cases. Median pain reduction for at least 3 months was reported in 60% (5-100%), median pain reduction for at least 12 months in 40% (10-100%), and median persistent pain reduction in 27.8% (10-85%) of the treated patients. In 30% of patients (7-100%), a second RT series was applied for inadequate pain response or early pain recurrence. No radiogenic acute or chronic side effects were observed. Conclusion: This PCS comprises the largest number of cases reported for RT in painful and refractory GNA. Despite variations in daily RT practice, high response and low toxicity for this treatment in a very large number of painful and refractory GNA cases renders low-dose RT an effective conservative therapy which can be applied prior to surgical procedures. (orig.)

  10. Survey of potential improvements during the course of the radiotherapy treatment. A patient questionnaire; Erfassung moeglicher Verbesserungen im Ablauf der Strahlentherapie. Eine Patientenbefragung

    Energy Technology Data Exchange (ETDEWEB)

    Momm, Felix; Jooss, David; Adebahr, Sonja; Duncker-Rohr, Viola; Heinemann, Felix; Kirste, Simon; Messmer, Marc-Benjamin; Grosu, Anca-Ligia [Universitaetsklinikum Freiburg, Freiburg im Breisgau (Germany). Klinik fuer Strahlenheilkunde; Xander, Carola J.; Becker, Gerhild [Universitaetsklinikum Freiburg, Freiburg im Breisgau (Germany). Palliativeinheit

    2011-11-15

    In the context of quality assurance, increasing demands are placed on the whole radiotherapy treatment process. The patients directly concerned generally do not realize most aspects of the quality assurance program (e.g., additional safety checks) during their daily therapy. It was the aim of this study to systematically ask patients about potential improvements during the course of radiotherapy treatment from their own perspective. In the defined time span (1 month), 624 radiotherapy patients (600 questionnaires were returned, 96.2%) were interviewed using a questionnaire newly developed to inquire about several aspects of their treatment. Furthermore, they were asked for their specific needs and suggestions for improvements that could be made during the course of radiotherapy treatment. Overall, the patients were satisfied with the course of their radiotherapy treatment and with patient care. As an example, about 90% agreed with the statement: ''My first contact with the radiation oncology unit proceeded with kindness and competence so that I was given the impression that I will be well cared for in this clinic.'' Considering the organization of the course of radiotherapy, a large majority of patients attached great value to set appointments for the therapy fractions. A main point of criticism was waiting times or delays caused by servicing or machine failures. Small, low cost improvements as music in the therapy room were considered as important as expensive measures (e.g., daylight in the therapy room). The patients emphasized the importance of staff friendliness. The situation of radiotherapy patients was, in general, satisfactory. Future improvements can be mainly expected from smooth organisation of both planning and treatment which can be achieved by electronic scheduling systems. Many results of the survey could be easily implemented in daily practice. In matters of organization radiation oncology with its complex procedures can be used as a model for other clinical departments. (orig.)

  11. Benchmark experiment to verify radiation transport calculations for dosimetry in radiation therapy; Benchmark-Experiment zur Verifikation von Strahlungstransportrechnungen fuer die Dosimetrie in der Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Renner, Franziska [Physikalisch-Technische Bundesanstalt (PTB), Braunschweig (Germany)

    2016-11-01

    Monte Carlo simulations are regarded as the most accurate method of solving complex problems in the field of dosimetry and radiation transport. In (external) radiation therapy they are increasingly used for the calculation of dose distributions during treatment planning. In comparison to other algorithms for the calculation of dose distributions, Monte Carlo methods have the capability of improving the accuracy of dose calculations - especially under complex circumstances (e.g. consideration of inhomogeneities). However, there is a lack of knowledge of how accurate the results of Monte Carlo calculations are on an absolute basis. A practical verification of the calculations can be performed by direct comparison with the results of a benchmark experiment. This work presents such a benchmark experiment and compares its results (with detailed consideration of measurement uncertainty) with the results of Monte Carlo calculations using the well-established Monte Carlo code EGSnrc. The experiment was designed to have parallels to external beam radiation therapy with respect to the type and energy of the radiation, the materials used and the kind of dose measurement. Because the properties of the beam have to be well known in order to compare the results of the experiment and the simulation on an absolute basis, the benchmark experiment was performed using the research electron accelerator of the Physikalisch-Technische Bundesanstalt (PTB), whose beam was accurately characterized in advance. The benchmark experiment and the corresponding Monte Carlo simulations were carried out for two different types of ionization chambers and the results were compared. Considering the uncertainty, which is about 0.7 % for the experimental values and about 1.0 % for the Monte Carlo simulation, the results of the simulation and the experiment coincide.

  12. Retrospective study on radiotherapy efficacy in case of painful heel spur; Retrospektive Studie ueber die Wirksamkeit der Strahlentherapie beim schmerzhaftem Fersensporn

    Energy Technology Data Exchange (ETDEWEB)

    Klossok-Niethammer, Ruth Giuliana

    2011-07-01

    Objective: The effect of radiotherapy in context of a plantar fasciitis in order to reduce pain was evaluated in this retrospective study. Patients and methods: The data of 188 patients who suffered of heel spur pain and who were irradiated in the period from 1994 to 2009 were evaluated in this study. All of them had at least one follow up examination after radiatiotherapy. The mean age amounted to 57 years. 76.5% of the patients were female. All patients described a local pain which was the basis for the indication. 74.4 % of the patients described pain especially under stress. The duration of anamnesis was averaged as follows: 15 % of the patients had pain for some weeks to 3 months, 43 % for 4 to 6 months, 28% even for 7 to 12 months. The period of medical history was longer than 12 months for 12 % of the patients in this study. 122 of 188 patients received orthopedic arch support (shoe inlays) as first therapy method. Most of the patients were irradiated using regular lateral opposing fields with photons of the energy 4 MV and 6 MV of a linear accelerator, applying a total dose of 6Gy in 6 fractions to 1,0Gy twice weekly. Only one patient was irradiated using a Co{sup 60} machine. The acquisition of data regarding the effect was performed on the last day of the radiotherapy and in 3 to 6 monthly follow ups. Additionally the doctors who attended the patients beyond the radiotherapy received a special questionnaire about the pain reduction, so that the follow up data could be completed. Results: On the last day of radiotherapy 120/188 patients (63,8%)reported an improvement of pain reduction, 7/188 patients (3,7%) absence of pain. For 52/188 patients (27.6 %) pain remained constant. At the second follow up examination after in the median 100 days the effect of radiotherapy of 165 patients could be evaluated, 43/165 patients (26 %) were pain free, 79/165 patients (47,8 %) reported an obvious pain reduction, and for 33/165 patients there was no pain improvement. At the third follow up examination after in median 503 days there were data of 94 patients that could be used for our study, 22/94 patients (23,4 %) felt a pain reduction and 56/94 patients (59,5 %) were completely painless. At the fourth follow up examination after in median of 1170 days patient database included 37 statements about pain. For 4/37 patients (10,8%) there was a pain reduction and for 32/37 patients (86,4 %) an absence of pain. After in median of 1590 days the fifth follow up took place, this showed statements of 84 patients about their pain. For 72/84 patients (85,7 %) radiotherapy achieved a complete absence of pain, an obvious improvement with 9/84 patients (10,7 %). Only 3/84 patients (3,5 %) described a steady pain symptomatology. All these results for pain reduction of 182 patients were achieved nearly without side effects, only 5 patients reported a light flush in the irradiated area. Conclusion: The radiotherapy of the painful heel spur appears highly effective, long-lasting and side-effect-free regarding to pain relief. The effect occurs often several months after radiotherapy, as far as it can be evaluated in this retrospective setting based on partially incomplete follow up data. We could not identify any prognostic factors.

  13. Function and application of ammonia-water adsorption refrigeration cycles; Funktion und Anwendung von Ammoniak-Wasser-Absorptionskaeltemaschinen

    Energy Technology Data Exchange (ETDEWEB)

    Heyse, Christoph; Stuerzebecher, Wolfgang [Tranter Solarice GmbH, Artern (Germany); Cibis, Dominik [Europaeische Studienakademie Kaelte-Klima-Lueftung, Maintal (Germany)

    2012-07-01

    The pursuit of the nations for more energy efficiency and environmentally friendly handling of nature and its resources is growing steadily. This new dimension of environmental awareness led to the fact that Germany has set the goal to become one of the most energy efficient and environmentally friendly economies of the world. Inter alia research and development in the areas of energy efficiency and renewable energy benefit from this. The meanwhile strongly forgotten potential of absorption chillers used for more than 150 years was due to rising energy costs and the rethinking in dealing with existing energy sources, newly discovered. The application of absorption chillers can be found everywhere, where a lot of heat is released unused into the environment. The implementation of the absorption refrigeration technology in power systems can have enormous energetic and thus ecological and economical benefits. Currently, mainly gas-fired cogeneration units whose main purpose is the generation of electricity can be used as heat sources. Particularly versatile is the application of NH{sub 3}-H{sub 2}O absorbers where heating temperatures are located at 100 Celsius and cooling temperatures up to -10 Celsius are needed, for example for air conditioning of buildings, cooling of food-stuff or for process cooling. The contribution under consideration reports on an overview of the working principle of ammonia water absorption chillers and presents various applications and uses in line with a combined power-heat-coldness coupling.

  14. S2k-Leitlinie zum Gebrauch von Präparationen zur lokalen Anwendung auf der Haut (Topika).

    Science.gov (United States)

    Wohlrab, Johannes; Staubach, Petra; Augustin, Matthias; Eisert, Lisa; Hünerbein, Andreas; Nast, Alexander; Reimann, Holger; Strömer, Klaus; Mahler, Vera

    2018-03-01

    Diese Leitlinie richtet sich an Assistenz- und Fachärzte der Dermatologie sowie an Kostenträger und politische Entscheidungsgremien. Die Leitlinie wurde im formellen Konsensusverfahren (S2k) von Dermatologen unter Einbindung von Apothekern erstellt. Die Leitlinie stellt allgemeine Aspekte der Pharmakokinetik sowie der regulatorischen Begrifflichkeiten dar. Es werden Empfehlungen zur Indikation von Magistralrezepturen sowie deren Qualitätssicherung gegeben. Die Bedeutung der galenischen Grundlagen und die Problematik bei einer Substitution gegeneinander verschiedener Grundlagen werden dargestellt. Die Leitlinie umfasst Kriterien zur Auswahl einer adäquaten Grundlage sowie spezifische Aspekte zur Therapieplanung. Die Leitlinie gibt Empfehlungen zum Management bei Unverträglichkeiten gegenüber Bestandteilen der Grundlagen oder Hilfsstoffe. © 2018 The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.

  15. PET and SPECT investigations in Alzheimer's disease; Nuklearmedizin und Demenz - Anwendung bei Morbus Alzheimer

    Energy Technology Data Exchange (ETDEWEB)

    Asenbaum, S. [Universitaetsklinik fuer Nuklearmedizin, Universitaetsklinik fuer Neurologie, Wien (Austria); Abteilung fuer klinische Neurologie, Universitaetsklinik fuer Neurologie, Waehringer Guertel 18-20, 1090, Wien (Austria)

    2003-07-01

    Nuclear medicine offers a wide range of possibilities to investigate dementia. Various SPECT and PET tracers will be introduced in this article first. Different questions concerning evaluation of dementia are discussed taking Alzheimer's disease (AD) as an example. It is important to perform nuclear medicine investigations on high technical level, using standardized methods as statistical parametric mapping (SPM) for evaluation. If neuroprotective therapies are available, an early diagnosis, the determination of risk factors and longitudinal investigations will be the focus of interest and the main goal of nuclear medicine. Apart from measuring cerebral perfusion and glucose metabolism the development of new ligands, concerning the cholinergic system and the visualization of amyloid plaques, is of great importance. (orig.) [German] Nuklearmedizin bietet bei der Erfassung und Beurteilung eines dementiellen Prozesses eine Vielzahl von Untersuchungsmoeglichkeiten. Anhand des Morbus Alzheimer (DAT) werden in dem vorliegenden Artikel neben einer kurzen Schilderung der zur Verfuegung stehenden Methoden die verschiedenen nuklearmedizinisch relevante Fragestellungen angefuehrt, zu deren Beantwortung die funktionelle Bildgebung Informationen liefern kann. Durch den Einsatz bestimmter, standardisierter Auswerteverfahren wie statistical parametric mapping (SPM) ist es moeglich, entscheidende Hinweise zur Diagnose und Differenzialdiagnose der DAT zu erlangen. In Zukunft werden, insbesondere bei einer Verfuegbarkeit neuroprotektiver Therapien, eine moeglichst fruehe Diagnosestellung und die Erfassung von Risikofaktoren sowie die Moeglichkeit einer Verlaufsbeobachtung in den Mittelpunkt des Interesses und in das Zentrum nuklearmedizinischer Untersuchungen ruecken. Vor allem fuer diese Anforderungen ist neben der qualitaetsvollen Untersuchung von zerebraler Perfusion und Glukosestoffwechsel eine Weiterentwicklung spezieller Liganden v. a. das cholinerge System betreffend und eine Markierung der Amyloidplaques vonnoeten. (orig.)

  16. Die häufigsten Fehler bei der FMEA-Anwendung und wie ich sie vermeiden kann

    OpenAIRE

    Schloske, Alexander

    2010-01-01

    Die FMEA stellt heutzutage eines der wichtigsten Werkzeuge des präventiven Risikomanagements dar. Die universell anwendbare Vorgehensweise des VDA hat sich dabei in der Industrie etabliert. Der Beitrag beschreibt aus der Sicht von 20 Jahren FMEA-Erfahrung, wie die FMEA zielführend erstellt wird und mit welchen Tipps und Tricks eine effiziente und effektive FMEA-Erstellung ermöglicht wird.

  17. Application and processing of paints hardened by electron beams. Anwendung und Verarbeitung von EB-haertenden Lacken

    Energy Technology Data Exchange (ETDEWEB)

    1984-01-01

    Electron beam hardening is a process for changing liquid surface coatings of different thicknesses by irradiation with electrons of high energy into solid, hard, elastic films. In contrast to the UV process, one can harden pigmented paints with electron beams. An electron accelerator, which remits free electrons is used as the energy source for starting the chemical reaction in the coating material. In order to irradiate flat parts, which were coated with liquid paint by rolling, pouring or spraying, equally with electrons, one must produce an electron curtain, similar to that in a paint pouring machine.

  18. Investigations on generation and use of a sludge-lime fertilizer. Untersuchungen zur Erzeugung und Anwendung eines Klaerschlamm-Kalkduengers

    Energy Technology Data Exchange (ETDEWEB)

    Boehnke, B; Weiling, R

    1980-06-01

    Sludge is an important energy and raw material source, which if possible should be utilized in agriculture. Through the addition of unslaked lime a hygienically safe product can be prepared with the help of a suitable treatment process and can be offered in granulated form as a valuable sludge-lime fertilizer. Sludges of different consistencies and origins were investigated. Varying amounts and types of lime were used and the products were tested for easy handling, storage capability and temperature influence on the hygienic conditions. In order to obtain a disseminable substance, a solid matter content of over 60% is necessary. This is achieved through variation of the lime content depending on the solid content of the respective sludge. According to the existing regulations, which fix the minimum CaO content in a lime fertilizer at 30%, a predewatering of the sludge up to 25%-30% of the solid matter content is sufficient. Economic viability is assured, specially in areas where intensive agricultural use of lime fertilizer is necessary. (orig.) With 32 refs., 15 tabs., 27 figs.

  19. Practical application of insect-parasitic nematodes and sterile flies; Praktische Anwendung insektenparasitischer Nematoden und sterilisierter Fliegen

    Energy Technology Data Exchange (ETDEWEB)

    Galle, F. [Bayerisches Staatsministerium fuer Ernaehrung, Landwirtschaft und Forsten, Muenchen (Germany); Loosjes, M. [De Groene Vlieg, Nieuwe Tonge (Netherlands)

    1987-07-01

    The company 'de Groene Vlieg' started with commercial control of the onion fly by means of the sterile insect technique. At the moment 10 per cent of the Dutch spring sown onions are treated with this method. The mass-rearing, the estimations of populations and the repeated releases of sterilized flies make it a rather complicated method. It can be applied economically per field, but only in areas with a concentration of onion growing. For export we see no possibilities yet. In principle the sterile insect technique can be applied also to other flies (carrot rust fly, cabbage root fly), but a suitable artificial diet is still lacking. Since some years we also rear the insect parasitic nematodes Heterorhabditis sp. and Neoaplectana bibionis. The later is experimentally used with success against Agrotis segetum caterpillars in lettuce. Research will yield more applications of nematodes against different pests. We use Heterorhabditis sp. in practice against the black vine weevil (Otiorhynchus sulcatus), a serious pest in glass houses, tree nurseries and gardens. Good control is achieved with a dose of one half to one million nematodes per square meter in moist soil and with temperatures above 12 degrees C. The application is similar to that of a chemical insecticide. The pest is killed by symbiontic bacteria, released by the nematodes after penetrating into the body cavity of the larvae. The nematodes are delivered by mail. If cooled they can be kept alive for over four weeks in the package. We export already to Switzerland and plan to export also to Western Germany. At this moment a possible admittance is under investigation in the Netherlands for application of a nuclear polyhedrosis virus against Spodoptera exigua caterpillars.

  20. Anwendung des Traumatherapieverfahrens -Narrative Expositionstherapie- bei komplex traumatisierten Patienten unter besonderer Berücksichtigung des Schlafes

    OpenAIRE

    Scharff, Anna-Lena

    2016-01-01

    Die Studie sollte aufgrund der häufigen Komorbidität einer Posttraumatischen Belastungsstörung mit der Borderline Persönlichkeitsstörung die Frage untersuchen, ob die Narrative Expositionstherapie einen Therapieerfolg bei komplex traumatisierten Patienten hat. Desweiteren sollte der Effekt der Therapie auf den Schlaf untersucht werden und eventuell prädiktive Zusammenhänge zwischen Schlafqualität und Therapieerfolg herausgestellt werden.

  1. Effects of platinum in biological systems - toxicology and pharmaceutical applications; Wirkungen von Platin in biologischen Systemen - Toxikologie und pharmazeutische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Nachtigall, D [Fraunhofer-Institut fuer Toxikologie und Aerosolforschung, Hannover (Germany)

    1998-12-31

    The title of this lecture has intentionally been worded rather vaguely with ``biological systems`` to do justice to the fact that there are meanwhile extensive data available on diverse levels of the toxicology and structure-effect relationships of some platinum compounds. These range from epidemiological descriptions over toxicity studies to molecular biological reaction mechanisms. Any discussion on the toxicity of a substance implies that the substance poses a direct or indirect hazard to humans. In the case of platinum and its compounds there are three main categories of exposure: platinum production including workplaces in the platinum processing industries; clinical treatment with antineoplastic platinum-containing agents; and, finally, the environment, where platinum levels are known to be rising since some years. The association between these exposures becomes clear when one considers the platinum pollution caused by automobile catalytic converters, hospital effluents, and by platinum-containing industrial products in the widest sense. [Deutsch] Der Titel des Vortrages ist mit `biologischen Systemen` sehr allgemein gehalten, da ueber die Toxikologie und die Struktur-Wirkungsbeziehungen einiger Platinverbindungen auf den verschiedensten Ebenen umfangreiche Daten vorliegen. Diese reichen von epidemiologischen Beschreibungen ueber Toxizitaetsstudien bis hin zu molekularbiologischen Reaktionsmechanismen. Die Diskussion um die Toxizitaet von Substanzen impliziert immer die direkte oder indirekte Gefaehrdung des Menschen. Im Falle des Platins und seiner Verbindungen existieren drei wesentliche Expositionsbereiche: Die Platingewinnung sowie die Arbeitsplaetze in der Platin verarbeitenden Industrie, die klinische Behandlung mit antineoplastischen Platinwirkstoffen und schliesslich die Umwelt, in der seit einigen Jahren ansteigende Platinkonzentrationen verzeichnet werden. Die Verbindung zwischen diesen Bereichen wird deutlich, wenn man die Platinimmissionen durch Automobilkatalysatoren, durch Krankenhausabwasser und im weitesten Sinne durch platinhaltige Industrieprodukte beachtet. (orig.)

  2. TRANSLATION ACQUISITION, TRANSLATION COMPERISON AND IST USAGE IN FOREIGN LANGUAGE COURSES UBERSETZUNGSFERTIGKEIT, UBERSETZUNGSVERGLEICH UND IHRE ANWENDUNG IM FREMDSPRACHENUNTERRICHT

    Directory of Open Access Journals (Sweden)

    Prof. Dr. Zeki KARAKAYA

    2009-05-01

    Full Text Available The purpose of this study is to enlighten the definition of translation acquisition, the differentiation from language acquisition by comparing translations of two authors having translation acquisition in different levels and through using these differences how can it be used in language teaching.In the first section, translation acquisition issue has been accentuated; by giving place to the definitions of different Scientifics a general survey about translation acquisition has been elicited. Moreover, in this section, in order to see how translation acquisition will be differentiated from language acquisition and bring out the difference; an application has been conducted on Students and the results have been ascertained.As it is known, translation comparison is a appliance for bringing in language teaching, comparative linguistics, comparative graphology, translation criticism and translation acquisition. However, in this study it has been tried out representing some suggestions and examples about translation on the subject of how can be benefited only in language teaching with translation comparison which is one of the medium of methodology. In the study comparative translation method has been applied and examples and suggestions about its functions on language teaching have been presented. Bu çalışmanın amacı çeviri edincinin tanımına, dil edincinden ayrışımına, farklı düzeylerde çeviri edincine sahip iki yazarın çevirilerinin karşılaştırılmasıyla bu farklılıklardan yararlanarak nasıl dil öğretiminde kullanılabileceğine ışık tutmaktır.İlk bölümde çeviri edinci konusu üzerine durulmuş, farklı bilim adamlarının tanımlarını yer vererek, çeviri edincine yönelik genel bir bakış sağlanmıştır. Ayrıca bu bölümde çeviri edincinin dil edincinden nasıl ayırt edileceğini görmek, aradaki farkı göz önüne sermek için öğrencilerle uygulama yapılmış ve sonuçları tespit edilmiştir. Bilindiği gibi çeviri karşılaştırması dil öğretimi, karşılaştırmalı dilbilim, karşılaştırmalı yazınbilim, çeviri eleştirisi ve çeviri edinci kazandırmak için kullanılan bir araçtır. Ancak bu çalışmada çeviri yöntembilimsel araçlarından biri olan çeviri karşılaştırmasıyla sadece dil öğretimi alanında nasıl yararlanılabilir konusunda bazı öneriler ve örnekler sunulmaya çalışılmıştır. Bu çalışmada karşılaştırmalı çeviri yöntemi uygulanmış olup dil öğretimindeki işlevine dair örnek ve öneriler sunulmuştur.

  3. Selective Catalytic Reduction (SCR) for mobile application - heavy duty diesel; Selektive Katalytische Reduktion (SCR) fuer die mobile Anwendung - LKW

    Energy Technology Data Exchange (ETDEWEB)

    Huennekes, E.; Neubauer, T. [Engelhard Technologies GmbH, Hannover (Germany); Roth, S.A.; Patchett, J.A. [Engelhard Corp., R and D, Iselin, NJ (United States)

    2006-07-01

    Different system configurations of particulate and NOx control via selective catalytic reduction (SCR) were discussed. Advantages and disadvantages were described and the final choice of the optimum system will strongly depend on the application, the market (US, EU) and the system costs. Especially when considering low temperature NOx control, the optimum adjustment of the NO{sub 2}/NO{sub x} ratio in front of an SCR system plays an important role. When generating NO2 over an oxidation catalyst, the resulting NO{sub 2}/NO{sub x} ratio strongly depends on temperature and space velocity. Steady state data show an optimum NO{sub 2}/NO{sub x} ratio between 35 and 60% at temperatures about 240 C. Three DOC systems in front of an SCR system were investigated with the purpose to generate high, low and optimum NO{sub 2}/NO{sub x} ratios. The fast SCR reaction at 1:1 NO: NO2 with NH{sub 3} is the preferred reaction pathway until either NO or NO{sub 2} are consumed. The benefit of an optimum designed DOC system can be seen in the transient response after a sudden increase in urea dosing. The time for the optimum designed system to reach maximum NO{sub x} conversion is much shorter compared with systems having excess NO or NO{sub 2} Ammonia oxidation catalysts (AMOX) are effective means in controlling ammonia from SCR systems. To be effective, AMOX must have selectivity to nitrogen over N{sub 2}O and NO{sub x}. (orig.)

  4. Field-effect gas sensors and their application in exhaust treatment systems; Feldeffekt-Gassensoren und ihre Anwendung in Abgasnachbehandlungssystemen

    Energy Technology Data Exchange (ETDEWEB)

    Schalwig, Jan

    2002-07-01

    Tightening environmental constraints on exhaust gas emissions of gasoline and Diesel engines led to a growing interest in new and highly sophisticated gas sensors. Such sensors will be required in future exhaust gas aftertreatment systems for the selective real time detection of pollutants such as nitric oxides, hydrocarbons and carbon monoxide. Restrictions on cost and device dimensions imposed by the automobile industry make semiconductor gas sensors promising candidates for the realization of cheap and small-size sensor devices. This work deals with semiconductor field effect devices with catalytically active platinum (Pt) electrodes and potential applications of such devices in automotive exhaust gas aftertreatment systems. To allow for continuous operation at high temperatures, silicon carbide (SiC) and group III-nitrides such as GaN and AlGaN were used as semiconductor materials. Different devices have been realized with such materials: SiC based MOS capacitors (MOSiC), GaN Schottky diodes and GaN/AlGaN high electron mobility transistors (HEMT). The principle feasibility of SiC and GaN based field effect gas sensors for automotive applications was tested under laboratory conditions using synthetic gas mixtures. Exhaust gas components such as carbon monoxide (CO), nitric oxides (NO and NO{sub 2}), various saturated and unsaturated hydro-carbons as well as water vapor, oxygen (O{sub 2}) and hydrogen (H{sub 2}) were used as test gases in appropriate concentrations with the sensor devices being operated in a range of temperatures extending from room temperature up to 600{sup o}C. (orig.)

  5. Powertrains 2011. Electronics, mechanics and hydraulics in application; Antriebssysteme 2011. Elektrik, Mechanik und Hydraulik in der Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Within the VDI/VDE conference at 13th-14th September, 2011 in Stuttgart (Federal Republic of Germany) the following lectures and posters were presented: (1) Sieve printed windings of rotating small drives and their evaluation (P. Braeuer); (2) Variable impedance induction motor - Measurement results of a variable impedance induction motor prototype (H. Gholizad); (3) Utilization of a multiphase winding in a star-polygon hybrid circuit for squirrel asynchronous motors for increasing the energy efficiency - generation of flooding waves of a 6-phase machine with a 3-phase connection (T. Knopik); (4) Virtual development of electric moors - Design of an asynchronous motor for propel drives by means of a numeric optimization and software automation (V. Reinhardt); (5) A hybrid microproduction system driven by piezoactuators and linear motors (C. Hast); (6) MRF actors with minimized standby losses (D. Gueth); (7) Experimental determination of rotor losses in a homopolar magnetic bearing (E. Fleischer); (8) Vibrational condition monitoring of coiler heads of electric large machines (C. Kreischer); (9) Recovery potentials in the electric propulsion technology - ''What is left usable from the energy'' (M. Schumacher); (10) Overall energy balance in the powertrain - The application decides - Energetic analysis of a powertrain (A. Thomas); (11) Optimal dimensioning of an actuator in the mechatronic overall system electric motor - gear - load (M. Lindner); (12) Electric and hydraulic hybrid actuator: Competing and complementary systems (K. Dehnert); (13) Intelligent pump drives - Simulation, condition monitoring, fault diagnosis and energy efficiency (S. Kleinmann); (14) Parametric models of the permanent magnet-synchronous machine (PMSM) under consideration of the impacts of magnetic saturation (F. Mink); (15) Electromagnetic, structure dynamic acoustic FEM simulation of an asynchronous motor for the evaluation of noise emission (J. Wibbeler); (16) Simulation and model based optimization of motion specifications for the transport of granules filled containers in processing machines (J. Holzweissig); (17) Improvement of the positioning accuracy of a parallel structure using static precontrol model (M. Wahle); (18) The synergism of bearing technology and direct drives using precision rotary axes in machine tools (J.-O. Hestermann); (19) Mechatronic systems for production machines (G. Schmid); (20) Projection of an automatic assembly system for textile spindles using the regulation DIN EN ISO 13849-1 (S. Barthel); (21) Design of servo drives for fast-running nonlinear gears (R. Blueml); (22) Synergism between comfort, safety and productivity - Trends in packaging machine construction - Intelligent and flexible automation platform simplifies the safety equipment of modular machines (H.B. Bruss); (23) Energy efficient hydraulic gears in association with electric axes - Frequency variable gears with displacement pump (D. Spalinger); (24) Investigation of the magnetic flux density in permanent magnetically excited synchronous machines with external rotors (A. Troeger); (25) The Schaeffler eWheel Drive Beta - first results (R. Fischer); (26) SINAMICS S 120 CM Application Shaft Generator Drive for energy efficient and reliable marine systems - applicative solutions based on industrial drive technology (Y. Guenduez); (27) Design and prove of concept of an innovative active fluid suspension system (T. Bedarff); (28) Simulation of hybrid vehicle propulsion with an advanced suspension system (S. Nallabolu); (29) Electrified single-wheel drive for agricultural machines (M. Geissler); (30) Vibrational excitation with electromagnetic drive systems (D. Wiedemann); (31) Control of a double generator with distribution gearbox and two synchronous machines - Design and control of a cost-efficient generator system for the regenerative power generation (C. Fraeger); (32) Interior cooling of permanent magnetically excited external rotor machines using a small wind energy generator as an example (S. Miersch); (33) Development of a kinetic energy storage for regeneratively generated power in buildings (H. Schaede).

  6. Mord, Selbstmord und Anomie : ein neuer Ansatz zur Operationalisierung und empirischen Anwendung des Anomiekonstruktes von Emile Durkheim

    OpenAIRE

    Mehlkop, Guido; Graeff, Peter

    2006-01-01

    Die Studie stützt sich auf Durkheims Anomietheorie, in der Mord- und Selbstmordraten als soziale Phänomene begriffen werden, die wiederum nur mit anderen sozialen Tatsachen zu erklären sind. Unter dieser soziologischen Perspektive interessiert also nicht das letztliche Motiv des Selbstmörders bzw. Mörders, sondern der Einfluss gesellschaftlicher Verhältnisse. Im Fokus dieser Analyse stehen variierende Mord- und Selbstmordraten zwischen Gesellschaften und über die Zeit hinweg. Verzichtet wird ...

  7. Mediation in matters of environmental policy and industrial project planning. Theory and case reports; Umweltmediation in Theorie und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Oppermann, B.; Langer, K.

    2000-07-01

    The guidebook is intended for regional or local decision-making bodies from industry and society, politics and administration involved in the planning, organisation and performance of public hearings in the context of industrial project planning, technology assessment and compliance with environmental policy and requirements. Participation of the public and conflict resolution are essential aspects of the guidebook which is one in a series of existing and planned publications on a variety of issues of public interest. (orig./CB) [German] Im Bereich technik- und umeltrelevanter Planungen werden immer haeufiger neue Formen der Buergerbeteiligung diskutiert. Die Akademie fuer Technikfolgenabschaetzung in Baden-Wuerttemberg hat es sich seit einigen Jahren zur Aufgabe gemacht, innovative Verfahren der diskursiven Verstaendigung und Konfliktloesung zu erproben und weiterzuentwickeln. Es zeigte sich, dass ein grosser Bedarf nach allgemeinverstaendlichen Praxisanleitungen besteht, so dass die Akademie begonnen hat, Praxis-Leitfaeden z.B. fuer regionale und lokale Entscheidungstraeger aus Politik, Verwaltung, Wirtschaft und Gesellschaft zu erarbeiten, als Hilfestellung bei Planung, Organisation und Durchfuehrung der vorgeschriebenen Verfahren. Neben dem vorliegenden Leitfaden sind auch weitere zu anderen Themen schon erschienen oder in Planung. (orig./CB)

  8. Automatische Ableitung und Anwendung von Regeln für die Rekonstruktion von Fassaden aus heterogenen Sensordaten

    OpenAIRE

    Becker, Susanne

    2011-01-01

    3D-Stadtmodelle finden seit einigen Jahren in immer stärkerem Maß und in den verschiedensten Bereichen Verwendung. Sie bilden unter anderem die Grundlage bei Stadtplanungen, für virtuelle Stadtrundgänge oder für die Berechnung von Simulationen. Internetdiensten wie Google Earth oder Microsoft Bing Maps ist es zu verdanken, dass 3D-Darstellungen von Gebäuden mittlerweile auch für eine breite Öffentlichkeit allgegenwärtig sind. Die erhöhte Nachfrage nach 3D-Gebäudemodellen verlangt nach effizie...

  9. Novel bispidine ligands with a possible application in nuclear medicine; Neue Bispidin-Liganden mit potenzieller Anwendung in der Nuklearmedizin

    Energy Technology Data Exchange (ETDEWEB)

    Rudolf, Henning

    2013-10-24

    Due to our current way of life and the environmental influences we are exposed in the industrial nations, cancer diseases turn out to be a more and more serious threat to our civilization. The ongoing research during the last decades leads to a better insight in cancer diseases and enables an earlier recognition of developing carcinoma. The detection of pathological tissue changes at an early stage increases the patients' chances of cure. Magnetic resonance tomography (MRT) and computed tomography (CT) as well as radiopharmaceutically assisted imaging techniques, like positron emission tomography (PET) and scintigraphy are an indispensable clinical tool in the oncological early diagnosis. By the development of multimodality imaging agents that combine the benefits of several imaging techniques, the early recognition of tumors can be more efficient and in consequence a matching therapy can be applied. This thesis deals with the synthesis of novel bispidine based ligands and their transition metal complexes as potential mono- and bimodal imaging agents for a {sup 64}Cu-assisted radiopharmaceutical application in positron emission tomography (PET) and optical imaging (OI). The synthesized ligands L and L{sup OH} are offering the opportunity to build up a ruthenium(II) polypyridine complex by one of the ligand's donor sets, to act as a fluorescence dye for optical imaging (OI), and to coordinate {sup 64}Cu{sup II} by the ligand's vacant cavity for positron emission tomography (PET). The Ru{sup II} complex exhibits two different fluorescence activities with two different lifetimes and only one of the two fluorescences is quenched by subsequent complexation of Cu{sup II}. The calculated Cu{sup II} stability constant of L and L{sup OH} is similar to that of the isomeric ligand N{sub 2}py{sub 2} which has been already evaluated as a {sup 64}Cu-radiotracer. Further transition metal complexes of Fe{sup II}, Fe{sup III} and Mn{sup II} are dealing with interesting structural properties like pentagonal bipyramidal geometries. For the development of stable and uncharged {sup 64}Cu{sup II} complex for positron emission tomography, three cyclic bispidine ligands containing amide donors were synthesized. These bispidine dioxo tetraaza macrocycles represent a new class of highly preorganized cyclic bispidine ligands by fusing the rigid bispidine backbone with the motif of a macrocyclic diamide. Due to the deprotonatable amides, they form stable, uncharged square-planar respectively square-pyramidal Cu{sup II} complexes and show also the stabilization of copper in the oxidation state +III. In evaluation experiments of the bispidine dioxo tetraaza macrocycles for a radiopharmaceutical application as {sup 64}Cu tracer for positron emission tomography, these ligands are showing an efficient radiolabeling with {sup 64}Cu >95% on benefiting timescale (60 min, tops) and a distinct specific activity up to 26 GBq/µmol. In particular the ligand H{sub 2}BBDT features a high stability versus EDTA and in human blood plasma. In radio challenge experiments, merely 8% of transchelation was detected against a 20fold excess of EDTA and nearly no decomplexation in human blood plasma after 48 h. Biodistribution studies in Kyoto-Wistar rats are showing a rapid and nearly complete clearance from blood and normal tissue after 60 min pi (post injection). The Cu{sup II} complex of the methyl propionate functionalized macrocycle H{sub 2}BBDTA-Me offers the opportunity to couple its saponificated methyl propionate linker to biovectors, nanoparticles or fluorescence labels.

  10. Legal aspects of the production and application of radiopharmaceuticals in Germany; Arzeinmittelrechtliche Aspekte der Herstellung und Anwendung von Radiopharmaka

    Energy Technology Data Exchange (ETDEWEB)

    Kuwert, T.; Prante, O. [Universitaetsklinikum, Erlangen (Germany). Nuklearmedizinische Klinik; Meyer, G. [Medizinische Hochschule Hannover (Germany). Klinik fuer Nuklearmedizin

    2009-06-15

    This article deals with the regulation of the production and use of radiopharmaceuticals in Germany. As in other countries, radiopharmaceuticals may be used when licensed by the German equivalent of the Federal Drug Agency or in clinical trials. Furthermore, non-licensed radiopharmaceuticals can be administered to patients for diagnosis when they are produced in the same institution and not more than 20 doses per week and radiopharmaceutical are given. A prerequisite for these three ways of use is the production of the radiopharmaceutical in question according to the guidelines of the good manufacturing practice (GMP) which creates considerable problems for the usually small PET centers installed in the German university hospitals. German law offers a further possibility to apply non-licensed radiopharmaceuticals for clinical purposes: their administration to patients is not forbidden when performed by a physician who produces the substance himself or is at least responsible for its synthesis. This regulation has, however, been met with criticism by government agencies. (orig.)

  11. Waste analysis - uses, problems and new paths in practice; Abfallanalysen - Anwendung, Probleme und neue Wege fuer die Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Rotter, S. [TUEV Hannover/Sachsen-Anhalt (Germany); Kost, T. [Umwelttechnik und Ingenieure GmbH (Germany); Bilitewski, B. [TU Dresden (Germany). Fachgebiet Abfallwirtschaft; Kock, O.; Seeger, H.; Urban, Arndt [Univ. Kassel (Germany). Fachgebiet Abfalltechnik

    2003-09-01

    Waste analytics; sample preparation; combustion behavior; sampling; balances of incineration and pollutants distribution. (orig.) [German] Abfallanalytik; Probenaufbereitung; Brennverhalten; Probenahme; Verbrennungsbilanz und Schadstoffverteilung. (orig.)

  12. Development and application of cryogenic radiometry with hard X-rays; Entwicklung und Anwendung der Kryoradiometrie mit harter Roentgenstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Gerlach, Martin

    2008-06-06

    To establish cryogenic radiometry with hard X-ray radiation for photon energies of up to 60 keV, a novel type of cavity absorber had to be developed for the cryogenic radiometer SYRES I, which is deployed by the Physikalisch-Technische Bundesanstalt (PTB) as primary standard detector at the electron storage ring BESSY II. This new type of cavity absorber allows for the complete absorption of hard X-ray radiation in combination with an appropriate sensitivity and an adequate time constant for the measurement of synchrotron radiation at BESSY II. As the process of fabrication of different types of absorbers is very time-consuming, the interaction of hard X-ray radiation with different absorber materials and geometries was studied intensively by using the Monte Carlo simulation code Geant4. The accuracy of the simulations was verified comparing them to scattering experiments performed at a wavelength shifter beamline at BESSY II with a calibrated energy dispersive detector. It was shown that Geant4 describes the photo-effect, including fluorescence as well as Compton- and Rayleigh scattering, with high accuracy. The simulations and experiments resulted in a cavity absorber with a gold base 550 {mu}m in thickness and a cylindrical shell made of copper 90 {mu}m in thickness to reduce losses caused by fluorescence and scattered radiation. Monochromatized synchrotron radiation of high spectral purity was then used to calibrate semiconductor photodiodes, which can be used as compact and inexpensive secondary standard detectors, against a cryogenic radiometer, covering the entire photon energy range of three beamlines from 50 eV to 60 keV with relative uncertainties of less than 0.5 %. Furthermore the spatial homogeneity of the spectral responsivity, the transmittance and the linearity of the photodiodes was investigated. Through a direct comparison of the free-air ionization chamber PK100, a primary detector standard of PTB used in dosimetry, and the cryogenic radiometer SYRES I the values of {mu}{sub en}/{rho} for photons in air were determined for the first time experimentally in the hard X-ray range from 10 keV to 60 keV with relative uncertainties of less than 1 %. (orig.)

  13. Anwendung der extrakorporalen Stoßwellentherapie bei kalzifizierender Periathropathia humeroscapularis, Fersensporn und Epicondylitis humeri - Erfahrungsbericht aus dem Wilhelminenspital

    Directory of Open Access Journals (Sweden)

    Feyertag J

    2004-01-01

    Full Text Available Die Stoßwellentherapie wird bei verschiedenen Indikationen, die unter konservativen Therapien schwer zu schwer zu behandeln sind, eingesetzt. Dazu zählen die kalzifizierenden Schultererkrankungen (Tendinitis calcarea, Epicondylitis humeri (EHR und die plantare Fasciitis mit/ohne plantarem Fersensporn (FSP. Berichtet werden die Ergebnisse von 147 Patienten (102 Frauen/45 Männer, mittleres Alter betrug 57,8 Jahre, die mittels einer einmaligen extrakorporalen Stoßwellentherapie (ESWT (Tend. calc. 82 %, FSP 11 % oder EHR 7 % mittels eines HMT-ReflecTron therapiert wurden. Verabreicht wurden im Mittel 1.800 Stoßwellen. Untersucht wurde die subjektive Verbesserung der Schmerzen anhand einer visuellen Analogskala vor und 6 Wochen nach der Therapie bei allen Patienten. Bei Patienten mit Tendinitis calcarea wurde auch eine Verbesserung der Funktion sowie Veränderungen der Kalzifizierungen untersucht. Bei allen Patienten konnte eine statistisch signifikante Verbesserung der Schmerzen sowie des Bewegungsumfanges beobachtet werden (p 0,0001. Röntgenaufnahmen ergaben eine partielle Verkleinerung der Kalkdepots bei ca. 80 % der Patienten. Aufgrund der geringen Zahl der Patienten fand sich für die EHR keine signifikante Verbesserung der Schmerzsymptomatik. Eine einmalige ESWT kann zu einer deutlichen Verbesserung der Schmerzsymptomatik und zu einer Verbesserung des Bewegungsumfanges führen. Bei 80 % der Patienten mit einer Tendinitis calcarea findet sich weiter eine partielle Verkleinerung der Kalkdepots 6 Wochen nach Therapie.

  14. Application of coal petrographic methods in petroleum and natural gas exploration. Anwendung kohlenpetrographischer Methoden bei der Erdoel- und Erdgasprospektion

    Energy Technology Data Exchange (ETDEWEB)

    Teichmueller, M.

    1971-02-15

    The relationship that exists between coalification and the formation of liquid petroleum and natural gas depends entirely upon the temperature in the earth's crust and the duration of heating. The degree of coalification can be determined by reflectivity measurements on very small vitrinitic (huminitic) inclusions in sedimentary rocks, because a satisfactory correlation has been established between mean reflectivity (R/sub m Oil/) and different parameters of chemical rank using 900 vitrites of different rank. This paper reports the considerable experience obtained with this method using cores and cuttings from boreholes of the German oil industry. Subsequently, examples from other countries are described which confirm the applicability of the method. Results obtained so far suggest that oil deposits may occur when the reflectivity (R/sub m Oil/) of the vitrinite lies between 0.3 and 1.0% (brown coal to high-volatile bituminous stage), whereas economic gas deposits may be found when R/sub m Oil/ extends from 0.7 to 2.0% (high-low volatile bituminous stage).

  15. Status reports on the development and application of acoustic emission analysis. Proceedings; Statusberichte zur Entwicklung und Anwendung der Schallemissionsanalyse. Beitraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2017-08-01

    The colloquium lectures represent the wide range of applications in acoustic emission analysis and testing in the areas of damage development and damage mechanisms, testing of components, condition monitoring, development of new measuring systems and sensors as well as software development regarding locating methods and signal analysis. One focus of the colloquium is on current hardware and software developments for status monitoring by means of AE monitoring. One of the papers was separately analyzed for this database. [German] Die Vortraege des Kolloquiums repraesentieren das breite Spektrum der Anwendungen der Schallemissionsanalyse und -pruefung in den Bereichen der Schadensentwicklung und Schadensmechanismen, Pruefung von Bauteilen, Zustandsueberwachung, Entwicklung neuer Messsysteme und Sensoren sowie Softwareentwicklung bezueglich Ortungsverfahren und Signalanalyse. Ein Schwerpunkt des Kolloquiums betrifft aktuelle Hard- und Softwareentwicklungen zur Zustandsueberwachung durch AE-Monitoring.

  16. Protection of workers during medical application of transcranial magnetic stimulation; Schutz der Beschaeftigten bei der medizinischen Anwendung transkranieller Magnetstimulation

    Energy Technology Data Exchange (ETDEWEB)

    Mischke, Marian [LAVG Brandenburg, Potsdam (Germany)

    2017-07-01

    Transcranial magnetic stimulation (TMS) is used in various applications in medicine. TMS is accompanied by relevant exposures by (extremely) low frequency magnetic fields. The applications can pose a threat to workers' health and safety at work through direct and indirect effects. Since the end of last year, the EMFV has been published to specify the obligations of the employer in association to ''Arbeitsschutzgesetz'' with regards to electromagnetic fields. Based on conventional types of equipment for the TMS, a possible procedure is presented for the employer to fulfill his duties.

  17. Advanced energy conversion and application - Decentralized energy systems. Papers; Fortschrittliche Energiewandlung und -anwendung - Schwerpunkt: Dezentrale Energiesysteme. Vortraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    Decentralized energy systems is the major topic of this VDI report which contains the proceedings of the VDI conference on advanced energy conversion and application. The decentralized energy systems are in the focus because it is expected that they will gain in significance in the course of restructuring and liberalisation of the energy markets and growing commitment to greenhouse gas mitigation. The subjects of the papers are the cogeneration technology in general, and specific systems for combined generation of heat, power and cold,(CHPC systems), systems for renewable energy generation, industrial energy technology, and analysis and optimization of energy systems. The report is intended to serve as a source of guidance and reference for manufacturers and operators of decentralized energy systems, for decision-making on energy policy, and for the energy industry, counselling firms and regulatory/surveillance bodies, and members of universities involved in relevant research and development work. (orig./CB) [German] Themenschwerpunkt des VDI-Berichts sind die dezentralen Energiesysteme, die im Spannungsfeld von fortschreitender Liberalisierung der Energiemaerkte und der Bemuehungen um die Reduzierung von Emissionen an Bedeutung gewinnen. Dabei widmen sich die Beitraege den Systemen zur Kraft-Waerme-Kaelte-Kopplung und zur Nutzung erneuerbarer Energie sowie der industriellen Energietechnik und der Analyse und Optimierung von Energiesystemen. Der Bericht wendet sich an Hersteller und Betreiber dezentraler Energieanlagen, an Entscheidungstraeger aus Politik und Wirtschaft, an Berater und Ueberwachungsinstitutionen sowie an auf diesem Gebiet taetige Hochschullehrer und -mitarbeiter. (orig.)

  18. Development and application of a new tool in driver task analysis; Entwicklung und Anwendung einer neuen Methodik zur Fahreraufgabenanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Fastenmeier, W.; Gstalter, H. [mensch-verkehr-umwelt Institut fuer Angewandte Psychologie, Muenchen (Germany)

    2003-07-01

    A framework for driver task analysis is derived from a model of the drivers information processing. The first step of the procedure (SAFE) is to divide a given driving task (e.g. left turning in a signalised intersection of a certain type) into subtasks. These subtasks are appointed to defined stretches of the road and the time structure of the subtasks is determined. For each subtask an analysis format is used, that organizes different requirements into perception, expectation, judgement, memory, decision and driver action. In a next step, typical driver errors are appointed to the subtasks. Afterwards the information gathered in the analysis procedure is compressed to ratings of the complexity and risk included in each subtask. After the crucial subtasks of a driving task have been determined, a list of those requirements that led to that rating can be compiled. These lists give the potential for aiding the driver e.g. by use of driver assistance systems. (orig.) [German] In den Verkehrswissenschaften existieren bislang keine verkehrsspezifischen Standardverfahren, die eine Anforderungsanalyse auf der Ebene der Fahraufgaben erlauben. Dieser Beitrag stellt die Grundzuege eines Verfahrens zur Fahraufgabenanalyse dar (SAFE: Situative Anforderungsanalyse von Fahraufgaben). Es basiert auf einer Modellvorstellung zu den Informationsverarbeitungsprozessen, die waehrend der Bewaeltigung der Fahraufgabe eine Rolle spielen. Der erste Schritt der Aufgabenanalyse besteht darin, eine ausgewaehlte Fahraufgabe (z.B. Linksabbiegen in einer ampelgeregelten Kreuzung bestimmten Typs) in Teilaufgaben zu zerlegen und eine zeitliche Strukturierung dieser Teilaufgaben vorzunehmen. Diese werden raeumlichen Segmenten zugeordnet, die nacheinander durchfahren werden muessen. Fuer jede Teilaufgabe erfolgt dann die eigentliche Anforderungsanalyse, die nach den Kapiteln Wahrnehmung, Erwartungsbildung, Beurteilung, Gedaechtnisprozesse, Entscheidung/Planung sowie Fahrzeugbedienung mit jeweils bis zu acht Unterkapiteln gegliedert ist. In weiteren Schritten werden die fuer jede Teilaufgabe typischen Fehler aufgelistet, Komplexitaets- und Risikoeinschaetzungen vorgenommen und daraus Listen von Anforderungen erstellt, die das Entlastungspotential bilden, das z.B. durch Fahrerassistenzsysteme ausgeschoepft werden koennte. (orig.)

  19. Siebenjährige Follow-up-Studie zur Anwendung des spannungsfreien Vaginalbandes (TVT zur Behandlung der Stressharninkontinenz

    Directory of Open Access Journals (Sweden)

    Nilsson CG

    2005-01-01

    Full Text Available Studienzweck: Evaluierung der langfristigen Heilungs- und Spätkomplikationsraten bei Stressharninkontinenz der Frau bei Behandlung mit dem spannungsfreien Vaginalband (TVT, das anhand einer minimal-invasiven Operation eingesetzt wird. Methodik: In drei Studienzentren durchgeführte prospektive Beobachtungs- und Kohortenstudie mit ursprünglich 90 Frauen, deren primäre Stressharninkontinenz einen operativen Eingriff erforderlich machte. Zu den Bewertungsvariablen gehörten ein Vorlagentest (Pad-Test zur Messung des Uringewichts je 24 Stunden, ein Stresstest, eine visuelle Analogskala (VAS zur Beurteilung des Beschwerdegrads sowie ein Fragebogen zur Beurteilung der subjektiven Wahrnehmung des Kontinenzstatus durch die Frauen. Ergebnisse: Als Follow-up-Zeitraum wurde ein durchschnittlicher Zeitraum von 91 Monaten (78–100 Monate festgelegt. Sowohl die objektive als auch die subjektive Heilungsrate lag bei den an der Follow-up-Studie teilnehmenden 80 Frauen bei 81,3 %. Bei 7,8 % der Frauen wurde ein asymptomatischer Prolaps der Organe des kleinen Beckens, bei 6,3 % De-novo-Drangsymptome und bei 7,5 % eine rezidivierende Harnwegsinfektion festgestellt. Weitere unerwünschte Nebenwirkungen des Verfahrens wurden nicht festgestellt. Schlussfolgerung: Die Wirkung der TVT-Operation zur Behandlung der Stressharninkontinenz der Frau bleibt über einen Zeitraum von 7 Jahren erhalten.

  20. Environmental penal law. Legal foundations, aspects of administrative law, practical applications. Umweltstrafrecht. Gesetzliche Grundlagen, verwaltungsrechtliche Zusammenhaenge und praktische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Meinberg, V. (Max-Planck-Institut fuer Auslaendisches und Internationales Strafrecht, Freiburg im Breisgau (Germany, F.R.)); Moehrenschlager, M. (Bundesministerium der Justiz, Bonn (Germany, F.R.)); Link, W. (eds.)

    1989-01-01

    The book intends to present the complexity of the penal code pertaining to environmental protection including the law on environmental offences in a way which makes the subject understandable for the reader. It is therefore not limited to the criminal law proper but looks at the administrative background and aspect of legal proceedings under these laws. Each area is dealt with by specialists from science and practice. The book is adressed to the experts in judiciary administration, industry, science and the interested layman. (orig.).

  1. Findings relating to the use of ACPI in Windows servers; Erfahrungen in der Anwendung von ACPI bei Windows-Servern

    Energy Technology Data Exchange (ETDEWEB)

    Huser, A.; Grieder, T.

    2004-07-01

    In a practical test, the possibilities and limits of the use of energy-saving sleep modes were compiled for servers of the lower price segment. Many of these servers are used by small to medium-sized enterprises and are left running around the clock, although they are not used at night or during the week-end. The implementation of the sleep modes is based on the so-called ACPI specification (Advanced Configuration and Power Interface), which was created by an industrial consortium. The most advanced of these is the implementation for the Windows Server 2003 operating system. With Linux, the sleep modes are not yet fully available. The test was therefore carried out with the Windows Server 2003 operating system. In many applications, and in particular when the servers are used as file or web servers, no operational disadvantages result from the use of the rest states. By making use of the lowest possible sleep mode during the night and at week-ends, the energy consumption of the server can be halved. For users, the results have been summarised in a two-page fact sheet, which is enclosed with this report as an appendix. (author)

  2. Contract manual for the gas industry. Practically oriented drafting and legally compliant application; Vertragshandbuch Gaswirtschaft. Praxisgerechte Gestaltung und rechtssichere Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Baumgert, Caspar (ed.) [WEMAG AG, Schwerin (Germany)

    2010-07-01

    The handbook presents all contracts on the delivery and grid side, including their specific clauses and variants along the value chain. This includes base load and auxiliary supply, contracts for private, commercial and industrial special customers as well as re-distributors, metering contracts, grid contracts, storage contracts, and biogas and heat supply contracting. The legal problems are outlined clearly and easy to understand, and the following questions are answered: What are the boundary conditions set by the new energy industry law and general civil law? Inhowfar are the contents of contracts influenced by legal specifications? What options are available for contract drafting, and what are their consequences? What contents are of particular importance? What are the requirements that result from price regulation by civil and cartel law? What is the role of licence fees in product design? What are the chances and risks of innovative products? What options for reaction do providers have in case of (impending) customer insolvency? (orig./RHM)

  3. Contract handbook power industry. Practical design and lgally waterproof application; Vertragshandbuch Stromwirtschaft. Praxisgerechte Gestaltung und rechtssichere Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Schoene, T. (ed.) [RWE Westfalen-Weser-Ems AG, Dortmund (Germany)

    2008-07-01

    The power economy exhibits numerous contractual characteristics. An indispensable condition for successful negotiating and use of the contracts in practice is the knowledge of the different organization possibilities as well as their handling. The author of the book under consideration reports on the contract design in the current economy. Questions of marketing and the product development are considered thereby. Contracts for services are described by the example of portfolio management. Under understandable preparation of the legal problem areas the author reports on the following questions: (a) What are the fundamental basic conditions of the new power industry law and the general civil law?; (b) Which content of the contracts are strongly affected by legal points?; (c) What are the possibilities of design, and what are there impacts?; (d) Which content of the contracts are of special interest?; (e) How must I proceed in order to gain optimal conditions?; (f) What are the chances and risks of innovative products?; (g) Which possibilities of reaction has a provider in the case of a (threatening) insolvency of a customer?.

  4. Effects of platinum in biological systems - toxicology and pharmaceutical applications; Wirkungen von Platin in biologischen Systemen - Toxikologie und pharmazeutische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Nachtigall, D. [Fraunhofer-Institut fuer Toxikologie und Aerosolforschung, Hannover (Germany)

    1997-12-31

    The title of this lecture has intentionally been worded rather vaguely with ``biological systems`` to do justice to the fact that there are meanwhile extensive data available on diverse levels of the toxicology and structure-effect relationships of some platinum compounds. These range from epidemiological descriptions over toxicity studies to molecular biological reaction mechanisms. Any discussion on the toxicity of a substance implies that the substance poses a direct or indirect hazard to humans. In the case of platinum and its compounds there are three main categories of exposure: platinum production including workplaces in the platinum processing industries; clinical treatment with antineoplastic platinum-containing agents; and, finally, the environment, where platinum levels are known to be rising since some years. The association between these exposures becomes clear when one considers the platinum pollution caused by automobile catalytic converters, hospital effluents, and by platinum-containing industrial products in the widest sense. [Deutsch] Der Titel des Vortrages ist mit `biologischen Systemen` sehr allgemein gehalten, da ueber die Toxikologie und die Struktur-Wirkungsbeziehungen einiger Platinverbindungen auf den verschiedensten Ebenen umfangreiche Daten vorliegen. Diese reichen von epidemiologischen Beschreibungen ueber Toxizitaetsstudien bis hin zu molekularbiologischen Reaktionsmechanismen. Die Diskussion um die Toxizitaet von Substanzen impliziert immer die direkte oder indirekte Gefaehrdung des Menschen. Im Falle des Platins und seiner Verbindungen existieren drei wesentliche Expositionsbereiche: Die Platingewinnung sowie die Arbeitsplaetze in der Platin verarbeitenden Industrie, die klinische Behandlung mit antineoplastischen Platinwirkstoffen und schliesslich die Umwelt, in der seit einigen Jahren ansteigende Platinkonzentrationen verzeichnet werden. Die Verbindung zwischen diesen Bereichen wird deutlich, wenn man die Platinimmissionen durch Automobilkatalysatoren, durch Krankenhausabwasser und im weitesten Sinne durch platinhaltige Industrieprodukte beachtet. (orig.)

  5. Avaliação da qualidade de vida de pacientes oncológicos em tratamento quimioterápico adjuvante

    Directory of Open Access Journals (Sweden)

    Sheila Mara Machado

    2008-01-01

    Full Text Available Estudio exploratorio descriptivo, cuyo objetivo fue evaluar la calidad de vida de pacientes con cáncer de mama e intestino, al inicio y tres meses después del tratamiento quimioterápico. Para la recolección de los datos fue utilizado el European Organization for research and treatment of cancer quality of life questionnaire. La muestra incluyó a 21 pacientes atendidos en una clínica de quimioterapia en Ribeirão Preto-SP, Brasil, en el período de octubre de 2005 a junio de 2006. Para el análisis de los datos fue utilizada la estadística descriptiva e inferencial. Los resultados indicaron una disminución en las funciones físicas, emocional, cognitiva y social, además, del aumento en los síntomas: fatiga, náuseas y vómitos, dolor, insomnio, pérdida del apetito, diarrea. A pesar de ello, el promedio de la evaluación del estado general de salud/calidad de vida aumentó después de los tres meses de tratamiento, demostrando que la quimioterapia adyuvante tuvo impacto positivo en la calidad de vida.

  6. Uso de teste de químio-sensibilidade para escolha da quimioterapia adjuvante no câncer gástrico avançado

    Directory of Open Access Journals (Sweden)

    Wilson Shinjiro Matsuzaki

    Full Text Available OBJETIVO: Introduzir e familiarizar em nosso meio o uso do teste de químio-sensibilidade MTT avaliando a ação de agentes quimioterápicos sobre células tumorais de 30 doentes com câncer gástrico avançado. Correlacionar os resultados do teste MTT com os aspectos clínicos, anátomo-patológicos e estádio utlizando a mesma metodologia do estudo realizado em pacientes japoneses na Universidade de Keio, Japão. MÉTODO: Foi realizado o teste MTT em tumores de 30 pacientes com diagnóstico de adenocarcinoma gástrico, submetidos ao tratamento cirúrgico no Departamento de Cirurgia da Faculdade de Ciências Médicas da Santa Casa de São Paulo. Foram estudados in vitro os seguintes agentes quimioterápicos: mitomicina C, doxorrubicina, cisplatina e 5-fluorouracil. RESULTADOS: Os índices de atividade sobre células tumorais foram: 16,6% para a mitomicina C, 10,0% para a doxorrubicina, 6,6% para a cisplatina e 6,6% para o 5-fluorouracil. Os resultados do teste MTT não tiveram correlação com a idade, sexo, aspectos microscópicos e estádio (p0,05. CONCLUSÕES: A ação dos agentes quimioterápicos estudados sobre células tumorais do câncer gástrico foi baixa. Os resultados da ação dos quimioterápicos in vitro não apresentou correlação estatística com a idade, sexo, aspectos microscópicos e estádio destes doentes. Utilizando a mesma metodologia, tanto em nosso meio como em pacientes japoneses, a quimio-sensibilidade se mostrou baixa em ambos os estudos, podendo-se deduzir também que os resultados da químiosensibilidade independe da etnia. Com o surgimento de novos agentes quimioterápicos, a expectativa é grande para melhores resultados na prática clínica. Com a utilização e difusão do teste MTT em nosso meio, poder-se-á criar protocolos e estudos multicêntricos para selecionar os quimioterápicos a serem utlizados.

  7. ''Radio-oncomics''. The potential of radiomics in radiation oncology

    Energy Technology Data Exchange (ETDEWEB)

    Peeken, Jan Caspar; Nuesslin, Fridtjof [Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Muenchen (Germany); Combs, Stephanie E. [Technische Universitaet Muenchen (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Muenchen (Germany); Helmholtz Zentrum Muenchen, Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Neuherberg (Germany)

    2017-10-15

    klinische Entscheidungsfindung, die Therapieplanung sowie die Nachsorge signifikant zu beeinflussen. Nach der Bildgebung erfolgt die Prozessierung der Daten sowie die Segmentierung von Zielstrukturen. Anschliessend werden durch Algorithmen Merkmale berechnet, welche die Form, Intensitaet, Textur und multiskalierte Filter abbilden. Prognostische Modelle koennen durch Kombination und Korrelation relevanter Merkmale mit klinischen Daten erzeugt werden. In retrospektiven Studien wurden Radiomics-basierte prognostische Modelle entwickelt, die eine Vorhersagekraft u. a. fuer Gesamtueberleben, Therapieansprechen, Fernmetastasierung und radiogene Nebenwirkung zeigten. Radiomics-Merkmale koennen ausserdem mit zugrundeliegenden genetischen Informationen korreliert werden (Radiogenomics) und zur Tumoridentifikation verwendet werden. In der Praezisionsmedizin der Zukunft wird die Strahlentherapie massgeblich durch Bildgebungs- und genombasierte Informationen beeinflusst werden. Behandlungskonzepte werden durch Individualisierung von Strahlendosis, Zielvolumendefinition und anderen therapieentscheidenden Faktoren auf den Patienten zugeschnitten werden. Dabei wird Radiomics durch Integration multipler Datensaetze und dadurch bedingter Optimierung der prognostischen Aussagekraft moeglicherweise eine herausragende Rolle einnehmen. Dieser Uebersichtsartikel fasst die aktuelle Literatur ueber die Anwendung des Radiomics-Konzepts in der Strahlentherapie zusammen. Die Notwendigkeit von klinischen Studien zur Integration von Radiomics-Modellen wird hervorgehoben. (orig.)

  8. Re-irradiation of the chest wall for local breast cancer recurrence. Results of salvage brachytherapy with hyperthermia

    Energy Technology Data Exchange (ETDEWEB)

    Auoragh, A. [University Hospital Erlangen, Department of Radiation Oncology, Erlangen (Germany); Hospital Fuerth, Department of Radiation Oncology, Fuerth (Germany); Strnad, V.; Ott, O.J.; Fietkau, R. [University Hospital Erlangen, Department of Radiation Oncology, Erlangen (Germany); Beckmann, M.W. [University Hospital Erlangen, Department of Gynecology and Obstetrics, Erlangen (Germany)

    2016-09-15

    Following mastectomy and adjuvant external beam radiation therapy in patients with breast cancer, the incidence of local or locoregional recurrence is approximately 9 % (2-20 %). Alongside the often limited possibilities of surgical treatment, radiation therapy combined with superficial hyperthermia is the most effective local therapy. In the present work, a retrospective analysis of salvage brachytherapy combined with superficial hyperthermia for chest wall recurrences is presented. Between 2004 and 2011, 18 patients with a total of 23 target volumes resulting from chest wall recurrences after previously mastectomy and external beam radiation therapy (median 56 Gy, range 50-68 Gy) were treated with superficial brachytherapy as salvage treatment: 8 patients (44 %) had macroscopic tumor, 3 (17 %) had microscopic tumor (R1), and 7 (39 %) had undergone R0 resection and were treated due to risk factors. A dose of 50 Gy was given (high-dose rate [HDR] and pulsed-dose rate [PDR] procedures). In all, 5 of 23 patients (22 %) received additional concurrent chemotherapy, and in 20 of 23 (87 %) target volumes additional superficial hyperthermia was carried out twice weekly. The 5-year local recurrence-free survival was 56 %, the disease-free survival was 28 %, and a 5-year overall survival was 22 %. Late side effects Common Toxicity Criteria (CTC) grade 3 were reported in 17 % of the patients: 2 of 18 (11 %) had CTC grade 3 fibrosis, and 1 of 18 (6 %) had a chronic wound healing disorder. Re-irradiation as salvage brachytherapy with superficial hyperthermia for chest wall recurrences is a feasible and safe treatment with good local control results and acceptable late side effects. (orig.) [German] Nach einer Mastektomie und adjuvanter Strahlentherapie bei Patientinnen mit Mammakarzinom kommt es bei 9 % (2-20 %) zum lokalen bzw. lokoregionaeren Rezidiv. Neben den oft limitierten operativen Behandlungsmoeglichkeiten ist die Strahlentherapie mit Oberflaechenhyperthermie die

  9. Planning benchmark study for SBRT of early stage NSCLC. Results of the DEGRO Working Group Stereotactic Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Moustakis, Christos [University Muenster, Department of Radiation Oncology, Muenster (Germany); German CyberKnife Center, Soest (Germany); Blanck, Oliver [UKSH Universitaetsklinikum Schleswig Holstein, Department of Radiation Oncology, Kiel (Germany); Saphir Radiosurgery Center, Guestrow and Frankfurt, Frankfurt (Germany); Ebrahimi Tazehmahalleh, Fatemeh [University Muenster, Department of Radiation Oncology, Muenster (Germany); City Hospital Dessau, Dessau (Germany); Chan, Mark ka heng [UKSH Universitaetsklinikum Schleswig Holstein, Department of Radiation Oncology, Kiel (Germany); Ernst, Iris; Haverkamp, Uwe; Eich, Hans Theodor [University Muenster, Department of Radiation Oncology, Muenster (Germany); German CyberKnife Center, Soest (Germany); Krieger, Thomas [University of Wuerzburg, Department of Radiation Oncology, Wuerzburg (Germany); Duma, Marciana-Nona; Oechsner, Markus [Technical University of Munich, Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Ganswindt, Ute; Heinz, Christian [Ludwig-Maximilians-University, Department of Radiation Oncology, Munich (Germany); Alheit, Horst; Blank, Hilbert [Radiationtherapy Distler, Bautzen (Germany); Nestle, Ursula; Wiehle, Rolf [University Medical Center Freiburg, Department of Radiation Oncology, Freiburg (Germany); Kornhuber, Christine; Ostheimer, Christian [University Halle, Department of Radiation Oncology, Halle (Germany); Petersen, Cordula [University Hospital Hamburg-Eppendorf, Hamburg (Germany); Pollul, Gerhard [University Mainz, Department of Radiation Oncology, Mainz (Germany); Baus, Wolfgang; Altenstein, Georg [University Hospital of Cologne, Cologne (Germany); Beckers, Eric; Jurianz, Katrin [Gamma Knife Center Krefeld, Krefeld (Germany); Sterzing, Florian [University Hospital Heidelberg, Heidelberg (Germany); Kretschmer, Matthias [Radiologische Allianz Hamburg, Hamburg (Germany); Seegenschmiedt, Heinrich; Maass, Torsten [Radiationtherapy and Cyberknife Center Hamburg, Hamburg (Germany); Droege, Stefan [Lung Clinic Hemer, Hemer (Germany); Wolf, Ulrich [University Leipzig, Department of Radiation Oncology, Leipzig (Germany); Schoeffler, Juergen [Radiationtherapy Department Boeblingen, Boeblingen (Germany); Guckenberger, Matthias [University Zurich, Department of Radiation Oncology, Zurich (Switzerland)

    2017-10-15

    Fruehstadium in Bezug auf die veroeffentlichten Empfehlungen der Arbeitsgemeinschaft Stereotaxie der Deutschen Gesellschaft fuer Radioonkologie (DEGRO). Planungscomputertomographie und Strukturdatensaetze (Planungszielvolumen, PTV; Risikoorgane, OARs) von 3 NSCLC-Patienten im Fruehstadium wurden an 22 Strahlentherapieabteilungen mit SBRT-Erfahrung gesendet: Jede Abteilung sollte einen Behandlungsplan nach DEGRO-Richtlinie generieren. Die Verschreibungsdosis betrug 3 Fraktionen mit je 15 Gy auf die 65%-Isodose. Es wurden 87 Plaene erzeugt: 36 mit intensitaetsmodulierter Arc-Therapie (IMAT), 21 mit dreidimensionaler konformaler Strahlentherapie (3D-CRT), 6 mit intensitaetsmodulierte Radiotherapie mit statischen Feldern (SF-IMRT), 9 mit helikaler Strahlentherapie und 15 mit robotergestuetzter Radiochirurgie. PTV-Dosisabdeckung und alle gleichzeitig erfassten OAR-Dosen hielten sich an die klinischen Grenzwerte der DEGRO-Richtlinie. Dennoch variierten durchschnittliche PTV-Dosen (Mittelwert 58,0 Gy; Spanne 52,8-66,4 Gy) und Dosiskonformitaetsindizes (Mittelwert 0,75; Spanne 0,60-1,00) zwischen Institutionen und Techniken (p ≤ 0,02). OAR-Dosen variierten erheblich zwischen den Institutionen, aber unabhaengig von der Technik (p = 0,21). Alle untersuchten Behandlungstechniken eignen sich gemaess den DEGRO-Empfehlungen fuer die SBRT von NSCLC im Fruehstadium. Die Homogenisierung der SBRT-Anwendung in Deutschland ist durch die Richtlinien moeglich; jedoch waren einige Charakteristika der Behandlungsplaene stark technik- und benutzerabhaengig und eine weitere Homogenisierung ist fuer kuenftige Studien und Empfehlungen noetig. Eine optimierte Bestrahlungsplanung sollte immer dem ALARA-Prinzip (so niedrig wie vernuenftig erreichbar) folgen. (orig.)

  10. Novel radiotherapy techniques for involved-field and involved-node treatment of mediastinal Hodgkin lymphoma. When should they be considered and which questions remain open

    Energy Technology Data Exchange (ETDEWEB)

    Lohr, Frank; Koeck, Julia; Abo-Madyan, Yasser [University of Heidelberg, Department of Radiation Oncology, University Medical Center Mannheim, Mannheim (Germany); Georg, Dietmar; Knaeusl, Barbara; Dieckmann, Karin [Medical University Vienna/AKH Vienna, Department of Radiation Oncology, Comprehensive Cancer Center, Vienna (Austria); Medical University Vienna/AKH Vienna, Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Comprehensive Cancer Center, Vienna (Austria); Cozzi, Luca [Medical Physics Unit, Oncology Institute of Southern Switzerland, Bellinzona (Switzerland); Eich, Hans Theodor [University Hospital, Department of Radiotherapy, Muenster (Germany); Weber, Damien C. [Paul Scherrer Institute, University of Bern, Center for Proton Therapy, Bern (Switzerland); Fiandra, Christian; Ricardi, Umberto [University of Torino, Radiation Oncology Unit, Department of Oncology, Turin (Italy); Mueller, Rolf-Peter [University of Cologne, Department of Radiation Oncology, Cologne (Germany); Engert, Andreas [University of Cologne, Department of Medical Oncology, Cologne (Germany)

    2014-10-15

    . (orig.) [German] Das Hodgkin-Lymphom (HL) ist eine Erkrankung mit hohen Heilungsraten. Die Verringerung von Spaetkomplikationen und Zweittumoren wird daher immer wichtiger. Zielvolumenkonzepte der Strahlentherapie (RT) veraendern sich gegenwaertig und Strahlentherapietechniken entwickeln sich sehr schnell weiter. Diese Uebersichtsarbeit stellt dar, inwiefern die Zielvolumenreduktion hin zum Involved-node(IN)-Konzept und hochentwickelte Strahlentherapietechniken wie die intensitaetsmodulierte Strahlentherapie (IMRT) und Protonentherapie, im Vergleich zu Involved-field(IF)-Konzept und 3-D-konformaler Strahlentherapie (3D-RT), die Belastung von Risikoorganen (OAR) mit hohen Dosen reduzieren koennen und welche Fragen in diesem Kontext noch geklaert werden muessen. Obwohl kein Vergleich aller verfuegbaren Techniken auf identischen Patientendatensaetzen existiert, entsteht folgendes Bild: Fortgeschrittene Dosisberechnungsalgorithmen (z. B. convolution-superposition/Monte Carlo) sollten im Rahmen der Behandlung des mediastinalen HL zur Anwendung kommen. INRT reduziert unter allen Bedingungen die behandelten Volumina im Vergleich zur IFRT, wobei die Hoehe des Vorteils von der jeweiligen INRT-Definition abhaengt. Die Anzahl der Patienten, die deutlich von hochkonformalen Techniken wie IMRT gegenueber der 3D-RT hinsichtlich der OAR-Belastung profitiert, ist bei INRT geringer. Die Konsequenz groesserer Volumina, die bei modernen Techniken mit eher isotroper Strahlanordnung mit niedrigen Dosen belastet werden, ist unklar. Die Art der verwendeten IMRT-Technik (statisch/Rotation) ist von geringer Relevanz. Alle fortgeschrittenen Photonentechniken resultieren in den gleichen Vorteilen und Nachteilen. Daher muss nur die Modulationstiefe abhaengig von den individuellen Behandlungszielen gewaehlt werden. Die Bestrahlung in tiefer Inspiration wird gegenwaertig evaluiert. Protonentherapie kann theoretisch bei hervorragender Hochdosiskonformalitaet die applizierte Integraldosis reduzieren

  11. Prevention of heterotopic ossification after total hip replacement. Using nonsteroidal antiinflammatory drugs versus radiation therapy: a prospective randomized trial; Prospektive Studie zur Vermeidung heterotoper Ossifikationen nach Hueftgelenksersatz. Nichtsteroidales Antirheumatikum versus Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Koelbl, O.; Flentje, M. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Eulert, J.; Barthel, T.; Knelles, D.; Kraus, U. [Orthopaedische Klinik Koenig-Ludwig-Haus Wuerzburg (Germany)

    1997-12-01

    Purpose: Two prospective trials were undertaken to assess the comparative efficacy of early postoperative irradiation with different radiation doses versus the postoperative use of nonsteroidal antiinflammatory drugs (NSAID) for prevention of heterotopic ossification (HO) following prothetic total hip replacement (THP). Patients and Method: Between 1992 and 1994 585 patients received THP. These patients were randomized in two longitudinal studies each with 3 treatment arms comparing postoperative irradiation with 4x3 Gy (101 patients), 1x5 Gy (93 patients), 1x7 Gy (95 patients) and the postoperative use of the NSAID indometacin for 7 days (113 patients) respectively for 14 days (90 patients) and acetyl salicyl acid (ASS) for 14 days (93 patients). Heterotopic ossification was scored according to the Brooker grading system. One hundred patients receiving no prophylactic therapy after total hip arthroplasty between 1988 and 1992 were analysed and defined as historical control group. Conclusion: Prophylactic irradiation of the operative site after hip replacement is more effective than the use of NSAID. Because no significant difference between the fractionated single dose irradiation was found and the latter is more comfortable for patients and more economical, irradiation with single 7 Gy fraction should be prefered. (orig./MG) [Deutsch] Zielsetzung: Mittels zweier prospektiver Studien wurde untersucht, inwieweit eine postoperative Radiotherapie mit unterschiedlichen Bestrahlungsdosen und die postoperative Gabe nichtsteroidaler Antirheumatika die Inzidenz heterotoper Ossifikationen nach endoprothetischem Gelenkersatz der Huefte reduzieren koennen. Patienten und Methode: 585 Patienten erhielten in den Jahren 1992 bis 1994 eine Totalendoprothese des Hueftgelenks. Diese Patienten wurden innerhalb zweier longitudinal angelegter, jeweils dreiarmiger Studien randomisiert. Verglichen wurde dabei eine postoperative fraktionierte Bestrahlung mit 4x3 Gy (101 Patienten), eine einmalige postoperative Bestrahlung mit 1x5 Gy (93 Patienten) und 1x7 Gy (95 Patienten), die postoperative Gabe der nichtsteroidalen Antirheumatika Indometacin ueber sieben Tage (113 Patienten) bzw. ueber 14 Tage (90 Patienten) und Acetylsalicylsaeure ueber 14 Tage (93 Patienten). Das Ausmass der Ossifikationen wurde nach dem Brooker-Score beurteilt. Als zusaetzliches Vergleichskollektiv wurde eine Gruppe von 100 Patienten ausgewertet, die in den Jahren 1988 bis 1992 ebenfalls eine Endoprothese des Hueftgelenks bekamen, bei denen jedoch keine Ossifikationsprophylaxe durchgefuehrt worden war. Schlussfolgerung: Die postoperative Bestrahlung ist der Gabe von nichtsteroidalen Antirheumatika hinsichtlich der Verringerung der Ossifikationsrate nach totalendoprothetischem Hueftgelenkersatz ueberlegen. Da sich kein signifikanter Unterschied zwischen der fraktionierten Bestrahlung mit 4x3 Gy und der einmaligen Bestrahlung mit 1x7 Gy fand, die einmalige Bestrahlung aber den Vorteil der geringeren Belastung fuer den Patienten hat und zusaetzlich kostenguenstiger ist, ist diese einem fraktionierten Bestrahlungskonzept vorzuziehen. (orig./MG)

  12. Radiotherapy of tumors under respiratory motion. Estimation of the motional velocity field and dose accumulation based on 4D image data; Strahlentherapie atmungsbewegter Tumoren. Bewegungsfeldschaetzung und Dosisakkumulation anhand von 4D-Bilddaten

    Energy Technology Data Exchange (ETDEWEB)

    Werner, Rene

    2013-07-01

    Respiratory motion represents a major challenge in radiation therapy in general, and especially for the therapy of lung tumors. In recent years and due to the introduction of modern techniques to 'acquire temporally resolved computed tomography images (4D CT images), different approaches have been developed to explicitly account for breathing motion during treatment. An integral component of such approaches is the concept of motion field estimation, which aims at a mathematical description and the computation of the motion sequences represented by the patient's images. As part of a 4D dose calculation/dose accumulation, the resulting vector fields are applied for assessing and accounting for breathing-induced effects on the dose distribution to be delivered. The reliability of related 4D treatment planning concepts is therefore directly tailored to the precision of the underlying motion field estimation process. Taking this into account, the thesis aims at developing optimized methods for the estimation of motion fields using 4D CT images and applying the resulting methods for the analysis of breathing induced dosimetric effects in radiation therapy. The thesis is subdivided into three parts that thematically build upon each other. The first part of the thesis is about the implementation, evaluation and optimization of methods for motion field estimation with the goal of precisely assessing respiratory motion of anatomical and pathological structures represented in a patient's 4D er image sequence; this step is the basis of subsequent developments and analysis parts. Especially non-linear registration techniques prove to be well suited to this purpose. After being optimized for the particular problem at hand, it is shown as part of an extensive multi-criteria evaluation study and additionally taking into account publicly accessible evaluation platforms that such methods allow estimating motion fields with subvoxel accuracy - which means that the developed methods belong to the most precise methods currently available. In clinical practice, however, there exists the problem that many medical facilities are not equipped with 4D imaging devices. Further, 4D images still offer only a snapshot of the patient-specific motion range and potential motion variability may limit the conclusions that can be drawn from them. To address these aspects, in the next part of the thesis - based on the optimized methods for motion field estimation in 4D CT image data and further including statistical motion information and models, respectively - model-based approaches for motion field estimation and prediction are developed. First, a novel approach for statistical modeling of lung motion in a patient collective is presented, and methods for adapting the model for prediction of patient-specific motion patterns are provided. The latter allow, for instance, the estimation of respiratory lung and lung tumor motion for radiation therapy treatment planning, if no temporally resolved image sequences are available for the patient; this use case is demonstrated. Further, techniques of multivariate statistics are applied to account for variations of motion patterns by integrating additional information provided by motion indicators used in 4D radiation therapy (e.g. abdominal belts or spirometer measurements) for a patient-specific, situation-related adaption of the motion fields computed using 4D images and the methods for motion field estimation described before. In the last part of the thesis, the developed methods are finally applied for assessing and analyzing the dosimetric impact of respiratory motion during radiation therapy of lung tumors. Both 3D conformal radiotherapy and intensity modulated radiotherapy are modeled as treatment modalities. In the case of intensity modulated radiotherapy, short delivery times for single radiation fields lead to the risk that the corresponding dose contributions are not only subject to a motion-induced dose blurring, but are also likely to be delivered to unintended positions in the patient (interplay effect). This risk is often only poorly accounted for in current simulation studies; therefore, an appropriate 4D dose calculation scheme is derived in this thesis. The scheme is used to illustrate that interplay effects indeed can lead to over- and/or underdosages of clinical relevance, even if safety margins are in principle large enough to capture tumor motion. Additionally, the influence of different factors (such as the temporal resolution of the 4D images underlying the 4D dose calculation) on the derived dose accumulation scheme and resulting dose distributions is analyzed. Finally and bMed on the techniques for the situation-related adaptation of motion fields estimated in the patient's 4D images, it is demonstrated that even only small variability of the patient's motion patterns can have significant impact on the dose distribution actually delivered to the patient - and should therefore (against common current practice) be accounted for during 4D dose calculation.

  13. Delayed somatic effects following extended radiotherapy. Studies of 135 patients with Hodgkin's disease in long-term remission (Freiburg collective, treatment years 1948 to 1974). Untersuchungen ueber somatische Spaetschaeden nach ausgedehnter Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Slanina, J

    1977-01-01

    A group of 135 patients who suffered from Hodgkin's disease with long-term remission following radiotherapy was investigated. By restricting the investigations to the patient group with long-term remission and correlative examinations, it was tried to differentiate between exclusive or principal delayed radiation effects and delayed effects due to other factors. The study reports about the most significant results obtained in the fields of catamnesis, laboratory diagnostics, hematology, pulmology, cardiology, thyroid function tests, neurology, andrology and dermatology. Due to the numerous detectable delayed effects the group of patients with long-term remission receives a special status. Although those effects are in no proportion to the deletary risks of an untreated Hodgkin's disease and though they are consequently tolerable in the present state of the therapeutic development, they must initiate the completion of the therapeutic concept including performance of radiotherapy and aftercare, because only then the risk for the patient provoked by these effects, which ranges beyond the malignity of this disease can be reduced or prevented.

  14. Contribution of PET and PET/CT in CTV/PTV-modulation for planning of intensity modulated radiotherapy (IMRT); Aktueller Beitrag der PET und PET/CT zur Zielvolumenmodulation fuer die biologischmedizinische Planung im Rahmen der intensitaetsmodulierten Strahlentherapie (IMRT)

    Energy Technology Data Exchange (ETDEWEB)

    Oehler, W. [Klinik fuer Radioonkologie und Strahlentherapie, Suedharz-Krankenhaus Nordhausen (Germany); Baum, R.P. [Klinik fuer Nuklearmedizin/PET-Zentrum, Zentralklinik Bad Berka (Germany)

    2004-12-01

    PET and PET/CT enlarge the possibilities of purely anatomic imaging by opening up new horizons in determining the metabolic and molecular properties of tumors. This enables to determine the spread of tumors with higher accuracy, especially concerning the primary staging and the diagnosis of recurrences. Patients with locoregional disease which are curable by surgery or local radiotherapy (eventually in combination with chemotherapy) can be differentiated from those patients, where only palliative treatment is indicated. Novel nuclear medicine procedures, which use specific tracers, open the door for the molecular treatment of tumors. This will be especially important for radiation oncology. In future it will be possible to define specific tumor areas within a morphologically homogeneous tumor (e.g. areas of tumor hypoxia, increased local tumor stem cell concentration, tumor parts with higher proliferative activity etc.). With IMRT (intensity modulated radiotherapy) we have already now the opportunity, to concentrate the dose to these specific tumor areas, without overloading normal tissues and organs at risk. (orig.)

  15. Indications and limitations of the radiotherapy of malignant neoplasms. An introduction for physicians and scientists working in oncology and radiology. Indikationen und Grenzen der Strahlentherapie boesartiger Neubildungen. Eine Einfuehrung fuer onkologisch und radiologisch taetige Aerzte und Naturwissenschaftler

    Energy Technology Data Exchange (ETDEWEB)

    Arndt, J [Friedrich-Schiller-Universitaet, Jena (German Democratic Republic). Radiologische Klinik und Poliklinik

    1978-01-01

    General remarks on the topic of oncoradiology precede the discussion of the problems of special oncoradiology concerning the respiratory system, the digestive tract, the mamma, the female genitals, the male genitals, the urinary tract, the nervous system, the hematopoietic system, the non-Hodgkin lymphomas, and malignant meoplasms of the supporting apparatus, of the thyroid, of the eye including malignant exophthalmus, of the ear, and of the skin. Each chapter contains introductory notes on morphological, radiobiological, and clinical aspects followed by discussions of the results of treatment, of the planning of radiotherapeutic measures as well as of problems of the patient's follow-up care. Numerous bibliographic references conclude the individual chapters. Of interest to physicians and scientists working in the field of radiotherapy.

  16. Hypofractionated stereotactic body radiotherapy (SBRT) for liver metastases. A retrospective analysis of 74 patients treated in the Klinikum rechts der Isar Munich; Die hypofraktionierte, stereotaktische Strahlentherapie von Lebermetastasen. Eine retrospektive Analyse von 74 Patienten des Klinikums rechts der Isar Muenchen

    Energy Technology Data Exchange (ETDEWEB)

    Heppt, Franz Johannes

    2013-06-12

    Purpose of this study was to evaluate the outcome of stereotactic body radiotherapy (SBRT) of liver metastases and prognostic factors for local control and overall survival. From 2000 to 2009 74 patients with 91 metastases were treated at the Department for Radiation Therapy and Oncology (TU Muenchen). With an observed local control rate of 75% after 1 year, SBRT proved as an effective local treatment option. Unfortunately, systemic tumor progression still dominates long term survival in many patients.

  17. Incentives for development and application of environmentally friendly biotechnological products and processes; Anreize fuer die Entwicklung und Anwendung umweltfreundlicher biotechnischer Produkte und Verfahren

    Energy Technology Data Exchange (ETDEWEB)

    Rhein, Hans-Bernhard; Endler, Katharina [Umweltkanzlei Dr. Rhein, Sarstedt (Germany); Ulber, Roland; Muffler, Kai; Mueller, Felix [Technische Univ. Kaiserslautern (Germany)

    2011-01-15

    Studies assign a tremendous growth potential related to biotechnology. However, the predicted proportion of biotechnological manufactured products in the chemical industry for the year 2010 by 20 % will more likely remain by today's 5 %. The study deals with the question why biotechnological products are currently established at the market in the obvious slow way. Therefore, the current constraints and existing respectively new incentive instruments referring to the white (industrial) biotechnology are analyzed to focus on the promotion of the development and application of environmentally friendly biotechnology products and methods. In addition to a search concerning environmental relevance and further development of white biotechnology, the postulated constraints and incentives as well as new promotions are discussed with the help of expert interviews. On the basis of a preliminary study - after further discussion with experts - concrete proposals on improvements related to an ongoing establishment of biotechnology will be derived. Based on case studies (2nd generation biofuels, polyhydroxybutyrate as biopolymer and phytase as an animal feed additive), the practical effects and specific conditions to incentives, from the perspective of biotechnological processes and environmentally friendly products are investigated. Overall, about 40 activities were recommended, which could be assigned to areas of direct government incentives (tax policy/subsidies, subsidies, education and research policy, basic political conditions, government demand and information policy/consumer intelligence) as well as non-governmental incentives (knowledge transfer and cooperation, organisation-related policy, capital market financing). (orig.)

  18. Arterial spin labelling in imaging of renal diseases and renal allograft pathology; MRT-Perfusionsmessung mit Arterial Spin Labelling. Anwendung fuer die Niere und Transplantatniere

    Energy Technology Data Exchange (ETDEWEB)

    Hueper, Katja; Gutberlet, Marcel [Medizinische Hochschule Hannover (Germany). Inst. fuer Diagnostische und Interventionelle Radiologie; Kuehn, Bernd [Siemens AG/Siemens Healthcare GmbH, Erlangen (Germany)

    2016-06-15

    Arterial Spin Labelling (ASL) is a technique for non-invasive and contrast-free assessment of perfusion with MRI. Renal ASL allows examination of renal pathophysiology, evaluation of the course of renal disease and therapy effects by longitudinal measurements as well as characterization of renal tumors. In this article, techniques of ASL will be explained and challenges of renal ASL will be emphasized. In addition, examples for clinical application of ASL for diagnosis of renal disease and renal allograft pathology will be given.

  19. Rehabilitation of the natural gas field Thoense with wet transport of natural gas; Sanierung des Erdgasfeldes Thoense unter Anwendung des Erdgasnasstransports

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, W.; Gerhartz, B.; Schmitt, D.; Uphoff, T. [BEB Erdgas und Erdoel GmbH, Hannover (Germany)

    1998-12-31

    Natural gas has been extracted the gas field of Thoense situated at the Northern fringe of the city of Hannover for over forty years. At all 10 bore sites the gas was dried with glycol dryers. While dealing with the problem of hydrocarbon emissions from the dryers it became evident, that some of the very old plants had to be rehabilitated. BEB operates the Thoense field on behalf of Elwerath/Brigitta/Deutz. An integrated concept, based on wet transport of natural gas, was used to remove the emission of hydrocarbons and rehabilitate the surface plants in order to cut operating costs. The field at Thoense is now economically efficient enough to continue operations for a long time. [Deutsch] Aus dem am nordoestlichen Stadtrand Hannovers liegenden Gasfeld Thoense wird seit ueber vierzig Jahren Erdgas gefoerdert. Die Gastrocknung erfolgte dort in ueblicher Weise mit Glykoltrocknungsanlagen an allen zehn Bohrungen. Bei der Bearbeitung des damit verbundenen Problems der Kohlenwasserstoffemissionen aus den Trocknungsanlagen wurde der Sanierungsbedarf an den z.T. sehr alten Anlagen deutlich. Das Feld Thoense wird von BEB fuer das Konsortium Elwerath/Brigitta/Deutz betrieben. Es wird gezeigt, wie mit einem integrierten Konzept auf der Basis des Erdgasnasstransportes die KW-Emissionen beseitigt wurden und gleichzeitig eine betriebskostensenkende Sanierung der obertaegigen Anlagen durchgefuehrt werden konnte. Damit wurde die wirtschaftliche Voraussetzung geschaffen, die Gasversorgung aus Thoense noch lange aufrecht erhalten zu koennen. (orig.)

  20. The use of radioactive materials in German schools. Obstacles and chances; Anwendung von radioaktiven Stoffen in Schulen in Deutschland. Hindernisse und Chancen

    Energy Technology Data Exchange (ETDEWEB)

    Vahlbruch, Jan-Willem [Hannover Univ. (Germany). Inst. fuer Radiooekologie und Strahlenschutz

    2015-07-01

    The basics for the understanding of radioactivity and radioprotection are set in the secondary school. Therefore the German-Swiss Radiation Protection Association already is trying to support the appropriate teaching of relevant topics in school for a long time. Unfortunately experiments with radioactive material are hampered in Germany by complex and confusing legislation. In this contribution the framework is described which is given by the German legislation for the use of radioactive sources in secondary schools. Additionally proposals for different simple experiments with radioactivity are presented which can be easily implemented in teaching and alternative methods are introduced like e.g. virtual experiments.

  1. Safety bey statistics? A critical view on statistical methods applied in health physics; Sicherheit durch Statistik? Ein kritischer Blick auf die Anwendung statistischer Methoden im Strahlenschutz

    Energy Technology Data Exchange (ETDEWEB)

    Kraut, W. [Duale Hochschule Baden-Wuerttemberg (DHBW), Karlsruhe (Germany). Studiengang Sicherheitswesen

    2016-07-01

    The only proper way to describe uncertainties in health physics is by statistical means. But statistics never can replace Your personal evaluation of effect, nor can statistics transmute randomness into certainty like an ''uncertainty laundry''. The paper discusses these problems in routine practical work.

  2. Applying ERNEUERBAR KOMM. in the context of rural development in north eastern Bavaria (Mittelfranken); ERNEUERBAR KOMM. Anwendung im Rahmen der Laendlichen Entwicklung Mittelfranken

    Energy Technology Data Exchange (ETDEWEB)

    Brumberg, Friedrich-Wilhelm [Amt fuer Laendliche Entwicklung Mittelfranken, Ansbach (Germany)

    2012-07-01

    Rural areas in Bavaria are faced with the same challenges as everywhere: Demographic chane, structural changes in agriculture and in small industries and trade, global climate change, and the requirements of the intended energy turnaround. This requires regional solutions. The contribution outlines the research project 'Integrative potential analysis for renewable energy sources' (ERNEUERBAR KOMM.) led by Prof. Dr. Klaerle (Ms.). Currently, the Mittelfranken regional development authority is carrying out two potential analyses in 12 communities, and five more regions with a total of 40 communities intend to participate as well.

  3. Application of biotests for the characterization of exposure pathways for endocrine disrupters from plastics; Anwendung von Biotests zur Charakterisierung der Expositionspfade fuer Umwelthormone aus Kunststoffen

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Martin; Oehlmann, Joerg [Frankfurt Univ., Frankfurt am Main (Germany). Abteilung Aquatische Oekotoxikologie

    2011-12-15

    The present project aims to characterise the exposure pathways for endocrine disruptors from plastic materials. A bioassay-based approach was employed to investigate and characterise the endocrine activity. Migration studies with food packaging and plastic preforms document the leaching of estrogen-like compounds from several types of plastic in the Yeast Estrogen Screen and the E-Screen. Additionally, anti-estrogenic activity was predominant in many samples. The detection of complex migration profiles provides evidence for the leaching of several, diverse-acting endocrine disruptors. Moreover, extracts of plastic food packaging exhibited agonistic activity on the estrogen receptor, retinoid X receptor, and vitamin D receptor. A theoretical exposure assessment for marine molluscs implies that endocrine disruptors from plastic might induce relevant effect in the environment. Within the exemplary investigation of bottled mineral water, 60% of the products were characterised as significantly estrogenic using the YES and E-Screen. These in vitro data point to the plastic packaging being one source of estrogenic contamination. An in vivo study employing the estrogen-sensitive model organism Potamopyrgus antipodarum supports this hypothesis. By using several analytical techniques (GC-MS, LC-MS/MS) we identified several well-known endocrine disruptors in bottled water and the plastic material, e.g. numerous phthalates and phenols. Moreover, potent antagonists of the estrogen and androgen receptor were extracted from bottled water. In a non-target analysis (Orbitrap-MS) a compound with the exact mass of 363.1992 [M+H{sup +}] correlated highly significantly with the biological activity. On the basis of the methods optimised and applied within the project we elaborated a set of aspects that are crucial for the applicability of bioassays to characterise the endocrine activity of complex samples. Employing a bioassay-based approach we provide evidence for the presence and migration of endocrine disruptors from plastic materials. In that sense, polymers represent a relevant but currently neglected source of human and environmental exposure to endocrine active compounds. Concerning the identification and toxicological characterisation of those chemicals, there is substantial need for further research. (orig.)

  4. Si{sub 3}N{sub 4} materials and applications; Si{sub 3}N{sub 4}-Werkstoffe und deren Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Woetting, G.; Leimer, G.; Gugel, E. [Cremer Forschungsinstitut GmbH und Co. KG, Roedental (Germany)

    2000-07-01

    Silicon nitrides, or silicon nitride-based materials, offer a very wide range of high-duty applications due to their high mechanical strength and good resistance to thermal, corrosive, and/or abrasive wear. Variation and optimization of their properties in response to intended applications is described in detail, also referring to potential new applications. (orig./CB) [German] Siliciumnitrid(Si3N4)- bzw. SN-Werkstoffe finden aufgrund ihrer hohen mechanischen Festigkeit sowie guten thermischen, korrosiven und/oder abrasiven Bestaendigkeit bereits vielfaeltige Anwendungen als hochbelastete Bauteile. Um fuer die jeweiligen Einsatzbedingungen optimale Werkstoffe einzusetzen, sind spezifische Modifizierungen moeglich und sinnvoll. Diesbezueglich kommerziell verfuegbare Si3N4-Werkstoffqualitaeten werden vorgestellt und derzeitige sowie potentielle Anwendungen ausgefuehrt. Die haeufig als Hemmnis fuer einen breiten Einsatz angefuehrten Bauteilkosten werden diskutiert. (orig.)

  5. Wissensstrukturierung im Unterricht: Neuere Forschung zur Wissensreprasentation und ihre Anwendung in der Didaktik (Knowledge Structuring in Instruction: Recent Research on Knowledge Representation and Its Application in the Classroom).

    Science.gov (United States)

    Einsiedler, Wolfgang

    1996-01-01

    Asks whether theories of knowledge representation provide a basis for the development of theories of knowledge structuring in instruction. Discusses codes of knowledge, surface versus deep structures, semantic networks, and multiple memory systems. Reviews research on teaching, external representation of cognitive structures, hierarchical…

  6. Evaluation of multiple trauma victims with 16-row multidetector CT (MDCT): a time analysis; Anwendung der 16-Zeilen-Mehrdetektor-CT in der Initialdiagnostik beim Polytrauma: Eine Zeitanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Heyer, C.M.; Nicolas, V. [Bochum Univ. (Germany). Inst. fuer Diagnostische Radiologie, Interventionelle Radiologie und Nuklearmedizin; Rduch, G.J. [Bochum Univ. (Germany). Klinik fuer Chirurgie; Wick, M.; Muhr, G. [Bochum Univ. (Germany). Medizinische Klinik III, Pneumologie, Allergologie und Schlafmedizin; Bauer, T.T. [Berufsgenossenschaftliche Kliniken Bergmannsheil, Ruhr-Univ. Bochum (Germany)

    2005-12-15

    Purpose: Description and time analysis of a 16-row MDCT protocol in the evaluation of multiple trauma patients considering transport, time of scanning, patient positioning, image reconstruction, and image interpretation. Materials and methods: Between May and December 2004, 60 multiple trauma patients underwent 16-row MDCT (Sensation, Siemens, Erlangen, Germany). The protocol included serial scanning of the head, spiral scanning of the cervical spine and contrast-enhanced spiral scanning of the thorax/abdomen with multiplanar reformations (MPR) of the thoracic/lumbar spine and the pelvis. All time intervals including transport, patient positioning, scanning, duration of MPR, total time in the examination room, and time to first and final image interpretation were prospectively evaluated. Furthermore, patient characteristics, trauma profiles, and mortality rates were recorded. Results: 46 male and 14 female patients (mean age 43.6 years) were enrolled in the study. Time analysis of 16-row MDCT revealed the following results (mean time standard deviation): Emergency room treatment and transport 19.2{+-}6.7 min, patient positioning 16.5{+-}6.5 min, scan duration 8.0{+-}3.3 min, total time in examination room 24.5{+-}7.2 min, image reconstruction including MPR 32.0{+-}16.4 min, and time of first (16.4{+-}4.7 min) and final image interpretation (82.5{+-}30.4 min). Trauma profiles revealed thoracic injuries in 35/60 patients (58.3%), head injuries in 23/60 patients (38.3%), abdominal injuries in 15/60 patients (25.0%), injuries of the cervical (9/60 patients, 15.0%), thoracic (12/60 patients, 20.0%), and lumbar spine (19/60 patients, 31.7%), pelvic injuries in 13/60 patients (21.7%), and injuries of extremities in 39/60 patients (65.0%). The mortality rate was 21.7%. (orig.)

  7. DIE NEUREGELUNG DES IFRS 10 ZUR ABGRENZUNG DES KONSOLIDIERUNGSKREISES – DIE ANWENDUNG DES EINHEITLICHEN BEHERRSCHUNGSMODELS AUF DIE ERFASSUNG VON STRUKTURIERTEN UNTERNEHMEN IM KONZERNABSCHLUSS

    OpenAIRE

    Markus Häfele

    2013-01-01

    In the past entities varied in their application of the control concept (IAS 27 and SIC-12) in circumstances in which a reporting entity controls another entity but holds less than a majority of the voting rights of the entity, and in circumstances involving agency relationships (IFRS 10.IN3). This conflict between IAS 27 and SIC-12 had led to inconsistent application of the concept of control. IAS 27 required the consolidation of entities that are controlled by a reporting entity, and it def...

  8. Photogalvanic effects induced by terahertz-lasers in semiconductor quantum films and applications; Terahertzlaserinduzierte photogalvanische Effekte in Halbleiter-Quantenfilmen und deren Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Wolfgang

    2008-06-16

    In this work photogalvanic effects where investigated in GaN/AlGaN heterostructures for the first time. For this purpose one of the strongest pulsed terahertz-lasers in the world was built and a computer controlled measurement system was developed. Additionally in this work an application of photogalvanic effects is presented, a pure-electric detection system, which allows to determine the polarisation state of terahertz radiation in sub-nanosecond time resolution. (orig.)

  9. Application of SiC masses as tube liners in municipal incinerators. Anwendung von SiC-Massen fuer Rohrverkleidungen in kommunalen Muellverbrennungsanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, In Soo.

    1993-09-02

    Phosphate-bonded SiC masses with different additives were investigated. The reference mass was a SiC mass consisting of 90% by mass of SiC and 10% by mass of Al[sub 2]O[sub 3]. The reactive alumina ([alpha]-Al[sub 2]O[sub 3]) served as reaction partner for the aluminium phosphate binder. The physical and thermomechanical properties as well as the corrosion resistance of the developed SiC masses were investigated, and the reactions of the additives with the aluminium phosphate binder were investigated. The best combination of properties required of a refractory liner for waste incinerators was found in masses with Si[sub 3]N[sub 4] additives. These masses have optimal physical and thermomechanical properties and a high resistance to the corrosive gases and alkaline slags produced in modern incinerators. (orig./EF)

  10. Cobit-Framework and process control engineering. Application of Cobit-Process documentation ME3; Cobit-Framework und die Netzleittechnik. Anwendung der Cobit-Prozessbeschreibung ME3

    Energy Technology Data Exchange (ETDEWEB)

    Bosin, Erwin [Tiwag-Netz AG, Thaur (Austria). Prozessrechner und USV

    2009-11-16

    Cobit (Control Objectives for Information and related Technology) is an internationally recognised framework which offers two approaches to facilitating the operativeness of the power system management. One is aimed at the selection of the relevant processes needed for meeting business requirements and the other at identifying possible improvements to control and steering mechanisms in the selected processes. This is documented by the selected Cobit ME3 process (''Ensure Compliance With External Requirements''). The high security level of the power system management must be maintained in this context.

  11. Application of a complex transport problem for simulating an acid rain episode in Europe. Anwendung eines komplexen Ausbreitungsmodells zur Simulation einer Episode saurer Deposition ueber Europa

    Energy Technology Data Exchange (ETDEWEB)

    Stern, R; Scherer, B

    1989-04-01

    For the first time in Europe, a comprehensive Eulerian regional tropospheric transport, transformation and removal model has been applied to an european wide acid deposition episode. This model, the Transport And Deposition of Acidifying Pollutants (TADAP) model incorporated detailed knowledge of the relevant physicochemical processes which lead to the formation of photochemical oxidants and acidifying pollutants. The EUROPA-model (EUM) of the German Weather Service, a limited area numerical weather prediction model, has been used to derive the total meteorological cloud variables. The application of the EUM/TADAP-modelling system to a 20 day-wintertime acid deposition episode in Europe showed that it is possible to model the principal features of the acid deposition system. In general, there is reasonable agreement between observed and predicted concentration and deposition patterns. Most discrepancies from observed trends can be explained by deviations between the modelled and the actual meteorology. First sensitivity studies with TADAP directed to reveal the influence of emission changes on the acid deposition system showed that there are considerable non-proportionalities between depositions of secondary pollutants and the emissions of the respective precursors. The nonlinearities arise due to the chemical coupling of the SO{sub x}/No{sub x}/VOC-system. This makes the design of control strategies to a highly complex task. Strategies developed to tackle different air pollution problems can therefore not be looked upon independently. (orig.) With 47 refs., 42 figs.

  12. Impacts of energy crop cultivation on nature and landscape. Development and application of an evaluation method; Auswirkungen des Energiepflanzenanbaus auf Natur und Landschaft. Entwicklung und Anwendung einer Bewertungsmethode

    Energy Technology Data Exchange (ETDEWEB)

    Wiehe, Julia

    2011-08-15

    For long-term planning, knowledge about the interrelationship of effects of the cultivation method and the sensitivity of ecological balance is essential. Hence, the objective of this thesis is the development of a method for the evaluation of the impacts of bioenergy crop production for biogas use on the natural environment. The developed method is in alignment with existing methods. It is also in alignment with those methods used within the practice of landscape planning, so that the method as well as the derived conclusions can be implemented into landscape planning practice in the future. The evaluation method has been applied in the three model regions Hildesheim, Soltau-Fallingbostel and Emsland. These test areas represent different physical regions in Lower Saxony and typical agricultural production conditions. On the basis of these results, general statements on the impact of bioenergy crop production on the ecological balance of the area can be made. [German] Grundlage fuer eine vorausschauende Steuerung des Ausbaus erneuerbarer Energien ist die Kenntnis der Zusammenhaenge der Wirkung des Energiepflanzenanbaus und der Empfindlichkeit des Naturhaushaltes. Ziel der Arbeit ist daher die Erarbeitung einer Methode zur umfassenden Bewertung dieser Auswirkungen auf den Naturhaushalt. Die Methode orientiert sich an bereits bestehenden und in der Praxis der Landschaftsplanung angewendeten Bewertungsmethoden, so dass sie ebenso wie die daraus abgeleiteten Schlussfolgerungen zukuenftig Eingang in die Planungspraxis finden kann. Die Bewertungsmethode wird in den drei Modellregionen Hildesheim, Soltau-Fallingbostel und Emsland angewendet, mit denen die verschiedenen Naturraeume und fuer Niedersachsen typischen landwirtschaftlichen Produktionsbedingungen abgebildet werden. Auf Grundlage dieser Ergebnisse koennen dann allgemeine Aussagen zu den Auswirkungen des Energiepflanzenanbaus auf den Naturhaushalt gemacht werden.

  13. Thermal insulating materials consisting of polyurethane rigid foam. Production - application - properties. 2. ed.; Waermedaemmstoffe aus Polyurethan-Hartschaum. Herstellung - Anwendung - Eigenschaften

    Energy Technology Data Exchange (ETDEWEB)

    Endres, Edmund; Kleser, Joachim

    2008-02-15

    Using rigid polyurethane (PU) / polyisocyanurate (PIR) foam as a thermal insulation material enables a conservation of resources and energy conservation. Environmentally harmful emissions significantly are reduced. Under this aspect, the authors of the contribution report on the production, application, technical and physical properties of rigid polyurethane foams. Sustainable construction with rigid polyurethane foam, quality assurance and product certification are further topics of this paper.

  14. Non-medical application of radioactive materials or ionizing radiation. German legal regulations; Die Anwendung radioaktiver Stoffe oder ionisierender Strahlung ausserhalb der Medizin. Deutsche Rechtsvorschriften

    Energy Technology Data Exchange (ETDEWEB)

    Huhn, Walter [Ministerium fuer Arbeit, Integration und Soziales NRW, Duesseldorf (Germany); Lorenz, Bernd [Lorenz Consulting, Essen (Germany)

    2016-05-01

    Non-medical imaging is regulated in Germany since the 2011 radiation protection law amendment and the simultaneous X-ray regulation amendment based on the Euratom guideline 96/29. The regulations contain lists with justified and non-justified activities.

  15. Automation of ultrasonic testing, instrumentation and rules for application and evaluation. Proceedings; Automatisierung der Ultraschallpruefung, Geraetetechnik und Regeln zur Anwendung und Auswertung. Vortraege des Seminars

    Energy Technology Data Exchange (ETDEWEB)

    Wuestenberg, H. [comp.

    1997-12-31

    The proceedings volume contains 18 lectures of the seminar addressing the following (selected) aspects: Requirements to be met by PC cards for US testing applications, defined by producers and appliers; digital technology and its impact on multichannel US testing instruments; the ALOK and array systems combined into one very efficient testing system (SAPHIR); a testing system combining US radiation source arrays and the pulsed eddy current method by means of highly integrated microelectronics (ASICs); regulatory standards and specifications for automated US testing; requirements for automated US testing in compliance with nuclear engineering codes; state of the art in standardisation for definition of required properties of US testing systems; critical review of the proposed standard relating to the TOFD method; automated evaluation shown with the example of US testing of pipelines. (orig./CB) [Deutsch] Dieser Band enthaelt 18 Vortraege mit folgenden Themen (Auswahl): Anforderungen an Ultraschall-PC-Karten aus der Sicht von Hersteller und Betreiber; Einfluss der Digitaltechnik auf Mehrkanal-Ultraschall-Pruefanlagen; Vereinigung der ALOK- und der Gruppenstrahler-Technik in einem leistungsfaehigen Pruefsystem (SAPHIR); Ein kombiniertes Pruefsystem fuer die Ultraschall-Gruppenstrahler- und Impuls-Wirbelstrom-Technik auf der Basis von hochintegrierter Mikroelektronik (ASICs); Regelwerke und Spezifikationen fuer die automatisierte Ultraschallpruefung; Anforderungen der kerntechnischen Regelwerke an die automatisierte Ultraschallpruefung; Stand der Normung bei der Charakterisierung der Eigenschaften von Ultraschall-Pruefsystemen; Kritische Bewertung des Normungsvorschlages zur Beugungslaufzeittechnik (TOFD); und Automatisierte Auswertung am Beispiel der Ultraschallpruefung von Fernrohrleitungen. (orig.)

  16. Comparison Re-invented: Adaptation of Universal Methods to African Studies (Conference Report Die Wiederentdeckung des Vergleichs: Zur Anwendung universeller Methoden in der Afrikaforschung (Konferenzbericht

    Directory of Open Access Journals (Sweden)

    Franzisca Zanker

    2013-01-01

    Full Text Available Drawing from a combination of specific, empirical research projects with different theoretical backgrounds, a workshop discussed one methodological aspect often somewhat overlooked in African Studies: comparison. Participants addressed several questions, along with presenting overviews of how different disciplines within African Studies approach comparison in their research and naming specific challenges within individual research projects. The questions examined included: Why is explicit comparative research so rare in African Studies? Is comparative research more difficult in the African context than in other regions? Does it benefit our research? Should scholars strive to generalise beyond individual cases? Do studies in our field require an explicit comparative design, or will implicit comparison suffice? Cross-discipline communication should help us to move forward in this methodological debate, though in the end the subject matter and specific research question will lead to the appropriate comparative approach, not the other way round.Mit Blick auf einige empirische Forschungsprojekte mit jeweils unterschiedlichem theoretischem Hintergrund wurde im Rahmen eines Workshops ein methodologischer Aspekt debattiert, der in der Afrikaforschung wenig Beachtung erfährt: der Vergleich. Die Teilnehmer(innen entwickelten Fragestellungen, stellten jeweils dar, inwieweit in den verschiedene Disziplinen der Afrikaforschung der Vergleich als Methode eingesetzt wird, und benannten spezifische Herausforderungen in diesem Zusammenhang für einzelne Forschungsprojekte. Unter anderem wurden folgende Fragen erörtert: Warum ist die explizit vergleichende Methode in der Afrikaforschung so selten? Ist vergleichende Forschung im Kontext Afrikas schwieriger anwendbar als in der Forschung zu anderen Regionen? Verbessert sie unsere Forschungsresultate? Sollten sich Forscher um Generalisierungen jenseits der Einzelfallstudien bemühen? Ist in der Afrikaforschung eine explizit komparative Forschungsplanung notwendig oder reicht es, implizit zu Vergleichen zu kommen? Die Kommunikation zwischen den Disziplinen sollte zur Weiterentwicklung dieser methodologischen Debatte beitragen – doch letztendlich werden Gegenstandsbereich und spezifische Fragestellung eines Forschungsprojekts zu einem angemessenen komparativen Ansatz führen, nicht andersherum.

  17. Manual of contracts for the electricity sector. Contracts that work: Drafting and proper legal application. 2. rev. ed.; Vertragshandbuch Stromwirtschaft. Praxisgerechte Gestaltung und rechtssichere Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Schoene, Thomas (ed.)

    2014-07-01

    This manual deals fundamentally with the drafting of contracts for the electricity sector. It covers all types of contracts on both the customer and the network side with their various special clauses and variants, specifically: basic supply, substitute supply, supply contracts for private, commercial and industrial special customers as well as redistributors, EFET contracts, network access contracts, supplier framework contracts, feed-in contracts, grid connection contracts and connection use contracts. The manual also addresses questions concerning electricity customer insolvency, an issue of growing importance. The following topics are furthermore dealt with in a practically oriented manner and with care being taken to explain the underlying legal issues in readily understandable language. What basic framework conditions are specified by the new energy economy laws and general civil law? What possibilities are available in drafting contracts and what are the ramifications in each case? What subject matters in a contract are of particular economic significance? How can concession contracts be designed in a market-conforming way when there is strong competition for qualified rights of way? What opportunities and risks are associated with innovative products? What options for action does a supplier have in the event of (threatening) customer insolvency? Model contracts from day-to-day management practice and tips, checklists and cautioning notes round off this manual.

  18. Magnetic resonance imaging of the hand in rheumatoid arthritis. New scientific insights and practical application; Magnetresonanztomographie der Hand bei rheumatoider Arthritis. Wissenschaftliche Ergebnisse und praktische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, K.G.A. [Charite - Universitaetsmedizin Berlin, Institut fuer Radiologie am Campus Mitte, Berlin (Germany)

    2006-05-15

    Magnetic resonance imaging (MRI) is a sensitive diagnostic modality for the detection of inflammatory changes in peripheral joints. Nevertheless, the widespread clinical use of MRI in assessing patients with early rheumatoid arthritis is still hampered by the technical complexity and higher cost of MRI compared with conventional radiography. This overview summarizes the results of recent research and gives practical tips on how to perform MRI of the hands. The authors present an MR protocol for hand imaging, discuss the pros and cons of low-field MR scanners, and outline pitfalls and artifacts. The MRI changes associated with rheumatoid arthritis such as synovitis, tenosynovitis, erosions, and bone marrow edema are described including their prognostic significance. The proven facts on the validation and grading of MR changes in rheumatoid arthritis are summarized. Finally, the role of MRI in the differential diagnosis of arthritis is critically discussed. (orig.) [German] Die Magnetresonanztomographie (MRT) ist ein sensitives Verfahren zur Detektion entzuendlicher Veraenderungen der peripheren Gelenke. Den breiten Einsatz der MRT im Fruehstadium der rheumatoiden Arthritis behindern derzeit jedoch der im Vergleich zur konventionellen Roentgendiagnostik hoehere technische Aufwand und vermehrte Kosten. Diese Uebersichtsarbeit fasst wichtige Studienergebnisse zusammen und gibt praktische Hinweise fuer Hand-MRTs. Ein geeignetes Sequenzprotokoll wird vorgestellt, Vor- und Nachteile von Niederfeld-MRTs werden beruecksichtigt, moegliche Fehlerquellen und Artefakte diskutiert. Magnetresonanztomographische Befunde bei rheumatoider Arthritis wie Synovitis, Tenosynovitis, Erosionen und Knochenmarkoedeme werden beschrieben und deren prognostische Bedeutung dargestellt. Gesicherte Fakten zur Validierung und Moeglichkeiten der Graduierung MR-tomographischer Veraenderungen bei rheumatoider Arthritis werden zusammengefasst. Der Nutzen der MRT zur differenzialdiagnostischen Abgrenzung von Arthritiden wird kritisch hinterfragt. (orig.)

  19. Anatomy of the fingers in MR imaging using a high resolution surface coil; Die Anatomie der Finger in der MRT unter Anwendung einer Hochaufloesungsspule

    Energy Technology Data Exchange (ETDEWEB)

    Maeurer, J. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Mueller, H.F. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Lemke, A.J. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Requardt, R. [Siemens AG, Erlangen (Germany); Stein, I. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Schedel, H. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Langer, R. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany); Felix, R. [Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany)

    1994-12-31

    MR-images of the fingers of twenty healthy volunteers were obtained at a 1,5-T whole-body system with a high resolution coil. Additionally, the fingers of two formalin-fixed anatomical specismen were imaged, fronzen and then subsequently sectioned for anatomic correlation. Measurements were recorded with a slice thickness of 2 mm. A 256x256 matrix and a 2,5 cam fiel of view (FOV) were used resulting in a pixel size of 0,01 mm{sup 2}. Based on the excellent depiction of anatomic detail and contrast resolution high resolution MRI of the fingers enabled identification of osseous and cartilaginous structures, as well as delineation of tendons, ligaments blood-vessels and dermal layers. (orig.) [Deutsch] An einem 1,5-T-Ganzkoerpertomographen wurden die Finger von 20 gesunden Probanden mit einer Hochaufloesungsspule zur Darstellung der Anatomie untersucht. Zum Vergleich erfolgte die Abbildung der anatomischen Strukturen an zwei formol- und alkoholfixierten Leichepraeparaten der Hand mittels MRT. Im Anschluss wurden die untersuchten Regionen am tiefgefrorenen Praeparat mit einer Bandsaege nachgeschnitten. Die MR-Messungen wurden mit einer Schichtdicke von 3 mm, einem Field of View (FOV) von 25 mm und einer Matrix von 256x256 Pixel durchgefuehrt. Die daraus resultierende Pixelgroesse betrug 0,01 mm{sup 2}. Der Weichteilkontrast und die hohe Ortsaufloesung ermoeglichten die Identifikation von Knochen- und Knorpelstrukturen sowie die Abgrenzung von Sehnen, Baendern, Blutgefaessen und Hautschichten. (orig.)

  20. Application of molecular biological methods in groundwater and drinking water analysis. Papers and discussions; Anwendung molekularbiologischer Verfahren in der Grund- und Trinkwasseranalytik. Textbeitraege und Diskussionsergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Kuhlmann, B.; Preuss, G. (eds.)

    2000-07-01

    Water management and water supply make demands on microbiology which so far were difficult to meet. However, new molecular-biological methods were developed by ecologically oriented scientists which open up new options in groundwater and freshwater analysis. [German] Aus dem Bereich der Wasserwirtschaft und -versorgung werden vermehrt Anforderungen und Fragen an die Mikrobiologie gestellt, die bisher aufgrund der eingeschraenkten methodischen Moeglichkeiten nur unzureichend beantwortet werden konnten. In unterschiedlichen, meist oekologisch orientierten Forschungsbereichen wurden jedoch neue, im Wesentlichen molekularbiologische Methoden entwickelt, die auch in Hinblick auf die mikrobiologische Untersuchung des Grund- und Trinkwassers neue Perspektiven eroeffneten. (orig.)

  1. Molekularbiologische Analyse der genetischen Diversität des Melitaea athalia / celadussa-Komplexes (Lepidoptera: Nymphalidae) unter Anwendung der ISSR-PCR auf Art-, Unterart- und Populationsebene

    OpenAIRE

    Achtelik, Gerdo

    2006-01-01

    Mit Hilfe der ISSR-PCR wurde erstmalig eine großräumige Populationsanalyse bei einer Tagfalterart am Beispiel von Melitaea athalia vorgenommen. Es konnten fünf verwandte Arten der Nymphalidae - Melitaea diamina, M. cinxia und M. aurelia sowie Boloria euphrosyne und Issoria lathonia - untereinander sowie gegenüber M. athalia differenziert werden. 90 Primer wurden geprüft, 8 Primer amplifizierten allein für M. athalia 410 Marker. Bei allen Taxa wurde eine sehr hohe Polymorphismusrat...

  2. Lactobacilli and ionising radiation: an example of the application to meat and meat products. Laktobazillen und ionisierende Strahlung als Beispiel einer Anwendung auf Fleisch und Fleischprodukte

    Energy Technology Data Exchange (ETDEWEB)

    Holzapfel, W.H. (Inst. fuer Hygiene und Toxikologie, Bundesforschungsanstalt fuer Ernaehrung, Karlsruhe (Germany))

    1992-01-01

    Ionising radiation provides a practical pasteurisation method for the terminal treatment of refrigerated vacuum-packaged meat products with the aim of shelf life extension. However, the relatively high radiation resistance ([gamma]-D[sub 10] = 0.70-1.2 kGy) of typical meat Lactobacilli, especially Lb. sake, selectively favours their total domination after treatments with 5 kGy. Typical meat strains show higher resistance (in term of [gamma]-D[sub 10] values the decimal reduction value due to irradiation) in the log (exponential) than in the stationary phase. This phenomenon was observed both in semi-synthetic broth and in meat, and may be explained in terms of a DNA repair mechanism operative during the exponential phase. Packaging under different gas atmospheres resulted in increased resistance to radiation in presence of N[sub 2], whilst the highest death rate was observed in presence of CO[sub 2]. (orig.)

  3. 2015 DACH annual meeting. NDE in research, development and application. Abstracts; DACH-Jahrestagung 2015. ZfP in Forschung, Entwicklung und Anwendung. Vortraege

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    The main topics of this meeting are: Computed Tomography; Air Ultrasound; Accreditation, certification, validation; CT algorithms; Ultrasound - imaging; Education; Digital X-ray detectors; Ultrasound - Simulation; Material characterization; Train; Phased Array; Aviation; Acoustic emission testing; Leak testing; Local defect resonance; Composite materials; Building construction; Standards and regulations; Condition and production monitoring; Surface method; POD; Renewable energy; Thermography. [German] Die Themenschwerpunkte auf dieser Tagung waren: Computertomographie; Luftultraschall; Akkreditierung, Zertifizierung, Validierung; CT Algorithmen; Ultraschall - Bildgebung; Ausbildung; Digitale Roentgendetektoren; Ultraschall - Simulation; Materialcharakterisierung; Bahn; Phased Array; Luftfahrt; Schallemissionspruefung; Dichtheitspruefung; Lokale Defektresonanz; Verbundwerkstoffe; Bauwesen; Normen und Regelwerke; Zustands- und Fertigungsueberwachung; Oberflaechenverfahren; POD; Erneuerbare Energien; Thermographie.

  4. The industrial application of fracture mechanics concepts discussed at the background of international standards and guidelines; Die industrielle Anwendung bruchmechanischer Konzepte vor dem Hintergrund internationaler Bewertungsvorschriften und Regelwerke

    Energy Technology Data Exchange (ETDEWEB)

    Zerbst, U. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Werkstofforschung; Langenberg, P. [Ingenieurbuero fuer Werkstofftechnik, Aachen (Germany)

    2000-07-01

    Many features from the background for an intensified application of fracture mechanics concepts in many industries world-wide. These include requirements for a permanent increase of the level of performance of technical components and structures by the introduction of new materials, joining technologies and design principles, the problem of ageing components and life extension, an increased emphasis on non-destructive in-service inspection combined with improved NDT techniques, and also a number of failure events caused by fatigue and fracture The aim of the present paper is to give a brief state-of-the-art review on how fracture mechanics is applied in different industrial branches today. This is based on standards and guidelines in the aerospace industry, in the nuclear and fossil power generation, in the chemical and petrochemical and the pipeline industry, in civil engineering, offshore technique and other fields. Based on the review an outlook is given on a future development that would be reasonable and desirable from the point of view of a basically unified philosophy of fracture mechanics application. (orig.) [German] Die Erhoehung der Leistungsparameter vieler Maschinen und Anlagen verbunden mit dem Einsatz neuer Werkstoffe, Fuegeverfahren und Konstruktionsprinzipien, der Betrieb vieler Strukturen ueber ihre projektierte Lebensdauer hinaus, technische Verbesserungen und ein durchgaengigerer Einsatz zerstoerungsfreier Defektpruefverfahren, aber auch immer wieder einmal auftretende Schadensfaelle bilden den Hintergrund fuer die zunehmende Nutzung bruchmechanischer Bewertungsvorschriften in der industriellen Praxis. Die vorliegende Studie zieht eine momentane Bilanz dieser Entwicklung am Beispiel von Fachbereichsstandards der Luft- und Raumfahrtindustrie, der konventionellen und Kernkrafttechnik, der Chemie und Petrochemie, der Pipelineindustrie, des Stahlbaus, der Offshore-Technik und anderer Bereiche. Ausgehend von dieser Bestandsaufnahme wird ein Ausblick auf die weitere Entwicklung versucht, wie sie vom Standpunkt eines moeglichst einheitlichen Anwendungskonzeptes fuer die bruchmechanische Bauteilbewertung sinnvoll und wuenschenswert erscheint. (orig.)

  5. Building materials. Structure and technology, types and properties, application and handlings. 2. rev. ed. Baustoffkunde. Aufbau und Technologie, Arten und Eigenschaften, Anwendung und Verarbeitung der Baustoffe

    Energy Technology Data Exchange (ETDEWEB)

    Schaeffler, H

    1980-01-01

    Details are given on the large variety of structural and interior building materials. Reference is made to the relation between the structure and technology of building materials on one hand and the properties and handling of building materials on the other hand. The following subjects are dealt with: Fundamentals (historical development, systematy of building materials, regulations, properties, property warranties); natural stone; lumber and derived lumber products (properties, species of lumber, flaws, supply cuts); ceramic building materials and glass (brick, earthenware, refractory materials); building materials with mineral binders added, concrete and mortar (technology, setting); metals (properties, technology); bituminous building materials (technology, properties); plastics (thermoplasts, elastomers, duroplastics, paints, adhesives, synthetic-resin mortar and synthetic-resin concrete); insulating materials, organic floor coverings, papers and paperboard, paints, adhesives and sealing materials; damage to buildings (types, causes, responsibility, avoidance). (HWJ).

  6. Nephrogenic systemic fibrosis after application of gadolinium-based contrast agents - a status paper; Nephrogene systemische Fibrose nach Anwendung gadoliniumhaltiger Kontrastmittel - ein Statuspapier zum aktuellen Stand des Wissens

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, M.; Uder, M. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Radiologie

    2007-06-15

    Recently the association of a rare disease named ''nephrogenic systemic fibrosis'' (NSF) with the administration of gadolinium-containing contrast media, especially gadodiamide (Omniscan, GE-Healthcare), was described. NSF is a scleroderma-like disease characterised by widespread tissue fibrosis. Until now, NSF cases were observed only in patients with kidney disease. Almost all patients were suffering from chronic renal insufficiency, 90 % of them required renal replacement therapy. The true incidence of the disease is unknown. First retrospective analyses of selected collectives of patients with end-stage renal disease showed 2 - 5 % cases of NSF after administration of Gadolinium-containing contrast agents with an odds ratio of 20 - 50 in comparison to non-exposed controls. NSF is a serious adverse reaction, which may result in severe disabilities and even death. Therefore all radiologists applying gadolinium-based contrast agents should be informed about this disease and the recent recommendations for its prevention. On the basis of the published data, Omniscan should not be used in patients with severe renal impairment (GFR < 30 ml/min/1.73 m{sup 2}) and those who have had or are undergoing liver transplantation. In neonates and infants up to 1 year of age, Omniscan should only be used after careful consideration. Also the other gadolinium-based contrast agents should be used in high-risk patients only after careful consideration using the lowest dose possible.

  7. Untersuchungen zur Expansion, funktionellen Charakterisierung und kontinuierlichen Bereitstellung von Hepatocyten für die Anwendung in bioartifiziellen Leberunterstützungssystemen

    OpenAIRE

    Iding, Kai

    2001-01-01

    Der vollständige Funktionsverlust der Leber kann in der modernen Medizin bisher nur durch den Austausch des funktionsuntüchtigen gegen ein gesundes Organ, d.h. durch eine Lebertransplantation behandelt werden. Da es jedoch weit mehr transplantationsbedürftige Patienten gibt als geeignete Spenderorgane zur Verfügung stehen, gibt es weltweite Anstrengungen zur Entwicklung alternativer Behandlungsmethoden. Nach bisherigem wissenschaftlichen Erkenntnisstand ist die bioartifizielle Leberunterst...

  8. Cutting down operating costs at sewage treatment plant through aimed application of new characterization methods; Betriebskostenreduzierung auf Klaeranlagen durch gezielte Anwendung neuer Charakterisierungsmethoden

    Energy Technology Data Exchange (ETDEWEB)

    Friedrich, H.; Potthoff, A. [Fraunhofer-Institut fuer Keramische Technologien und Sinterwerkstoffe (IKTS), Dresden (Germany); Friedrich, E. [Ingenieurgesellschaft fuer Wasser und Entsorgung mbH, Radebeul (Germany)

    1999-07-01

    Mechanical dewatering of sewage sludge is state of the art. Because of increasing cost, more stringent regulations (act on waste recycling 'Kreislaufwirtschaftsgesetz' and the technical code on municipal waste), and the lack of landfill space, expensive thermal processing techniques are gaining ever greater weight. To assure that disposal costs remain reasonable, mechanical dewatering must be more and more enhanced. The following need to be optimized and enhanced: sludge properties, conditioning, and dewatering. (orig.) [German] Klaerschlaemme maschinell zu entwaessern ist Stand der Technik. Steigende Kosten, verschaerfte Bestimmungen (Kreislaufwirtschaftsgesetz, TA Siedlungsabfall) und fehlende Deponien geben den teuren thermischen Behandlungsverfahren ein immer groesseres Gewicht. Damit die Entsorgung bezahlbar bleibt, muss immer staerker mechanisch entwaessert werden. Optimiert und verbessert werden muessen die Schlammeigenschaften, die Konditionierung und die Entwaesserung. (orig.)

  9. Control-technical optimization of topped denitrification through fuzzy control; Regelungstechnische Optimierung der vorgeschalteten Denitrifikation durch Anwendung von Fuzzy-Control

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, U. [Hydroplan Ingenieurgesellschaft, Worms (Germany); Poepel, H.J. [Technische Univ. Darmstadt (Germany). Inst. WAR - Wasserversorgung, Abwassertechnik, Abfalltechnik, Umwelt- und Raumplanung

    1999-07-01

    The present paper describes complex fuzzy systems for controlling nitrogen elimination at plants with topped denitrification. For the design and testing of the fuzzy systems, dynamic simulation calculations and experimental tests were carried out in a semi-technical pilot plant. The controlling fuzzy systems indicate the supposed oxygen values for individual tank areas and the most appropriate partitioning of the activated sludge tank (anoxic/aerobic zone) as a function of the input quantities used. It is established that, with the more flexible control behaviour, a more stable nitrogen elimination and, at the same time, a cut in the amount of air transferred to the system can be attained in comparison with a conventional control. (orig.) [German] Im Rahmen dieses Beitrags werden komplexe Fuzzy-Systeme zur Regelung der Stickstoffelimination in Anlagen mit vorgeschalteter Denitrifikation vorgestellt. Zum Entwurf und zur Erprobung der Fuzzy-Systeme wurden dynamische Simulationsrechnungen und experimentelle Untersuchungen an einer halbtechnischen Versuchsanlage durchgefuehrt. Die uebergeordneten Fuzzy-Systeme geben in Abhaengigkeit der verwendeten Eingangsgroessen Sauerstoffsollwerte fuer die einzelnen Beckenbereiche und die jeweils guenstigste Aufteilung des Belebungsbeckens (anoxische/aerobe Zone) vor. Die Ergebnisse zeigen, dass durch das flexible Reglerverhalten eine stabilere Stickstoffelimination und gleichzeitig eine Einsparung an eingetragener Luftmenge im Vergleich zu einem konventionellen Regelsystem erreicht werden kann. (orig.)

  10. Screening und Quantifizierung organischer Spurenstoffe mittels UPLC-HRMS:Entwicklung von Methoden und Anwendung zur Unterscheidung historischer und aktueller Spurenstoffe in einem ehemaligen Rieselfeld

    OpenAIRE

    Wode, Florian

    2014-01-01

    Aufgrund zunehmender Wasserknappheit gewinnt die Nutzung von gereinigtem Abwasser (Klarwasser), bezeichnet als Water Reuse, weltweit an Bedeutung. Neben herkömmlichen chemischen und mikrobiologischen Parametern spielen organische Spurenstoffe zunehmend eine Rolle bei der Beurteilung der Wasserqualität, die über mögliche Nutzungsformen entscheidet. In dieser Arbeit wurde die Spurenstoffbelastung in Grund- und Oberflächenwasser eines ehemaligen Rieselfeldgebietes untersucht, in dem seit 2005 Kl...

  11. Deep desulfurization of jet fuel for applications in mobile fuel cell systems; Tiefentschwefelung von Flugturbinenkraftstoffen fuer die Anwendung in mobilen Brennstoffzellensystemen

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yong

    2012-07-01

    Fuel cell powered APUs are promising for the on-board electricity supply in heavy vehicles, aircraft and ships because of their high efficiency and low emission of pollutants. The catalytical reforming with subsequent gas processing units is applied to operate the fuel cell system with onboard available fuels. Within the reformer the liquid fuel is converted into a hydrogen-rich synthesis gas in the presence of metal catalysts. However, an on-board desulfurization of fuels is required to avoid the deactivation of catalysts in the fuel processing unit as well as in the fuel cell. The present work aims at developing a technically feasible deep desulfurization process for fuel cell powered APUs with theoretical and experimental study as well as procedural analysis. The focus of the work is on the desulfurization of jet fuels in liquid phase, since the reformer currently developed in IEK-3 is designed for aviation applications of fuel cell APUs and it can only be operated by liquid jet fuels. In addition, the desulfurization of marine gas oil was investigated to fulfill the sulfur requirement of the fuels for the application of fuel cell A PUs for inland navigation. In the petroleum industry, low-sulfur fuels are often obtained by hydrodesulfurization and the S-Zorb Process. However, these conventional methods are highly inconvenient for reducing sulfur compounds to the desired level in a mobile fuel cell system, since improvements of the desulfurization efficiency are limited by increasingly severe operating conditions and escalating costs. Moreover, the hydrodesulfurization and the S-Zorb Process are not suitable for mobile applications, since hydrogen recycling is required, which is not possible with H{sub 2} syngas. To this end, a large number of processes discussed in the literature were assessed with regard to their application in fuel cell APUs. Three potentially suitable processes were selected: pervaporation, adsorption, and hydrodesulfurization with pre-saturation. Within a series of experiments in the laboratory, these processes were investigated with respect to their desulfurization ability and durability, while the required heat amount and electrical energy demand were determined by modeling and simulation. Subsequently, the potential of the desulfurization processes for technical applications were evaluated by a procedural and energetic analysis. As a result, the hydrodesulfurization with presaturation is most suitable for desulfurization of jet fuels for the application of fuel cell driven APUs in aircraft. A combination of pervaporation and adsorption is although applicable for the desulfurization of jet fuel and marine gas oil, more research work is required to increase the long-term stability of the membrane material. (orig.)

  12. Entwicklung und Anwendung bildgebender Verfahren für die Messung der elektrischen Feldstärke mit Hilfe der Lochbrennspektroskopie

    OpenAIRE

    Balzer, Herbert

    2002-01-01

    In der Arbeit wird ein neues bildgebendes Verfahren zur optischen Sensorik der elektrischen Feldstärke vorgestellt, das auf der laserspektroskopischen Methode des stabilen spektralen Lochbrennens beruht. Hierbei erfolgt die Bestimmung der Feldstärkeverteilung durch Messung der E-Feldinduzierten Änderung der Absorption im Zentrum eines stabilen spektralen Loches, das mit einem schmalbandigen Laser in das Absorptionsspektrum einer Sensorschicht, bestehend aus dem Polymer Polyvinylbutyral dotier...

  13. Considerations on the application in supermarkets. The high performance air cooler in the course of time; Ueberlegungen fuer die Anwendung im Supermarkt. Der Hochleistungsluftkuehler im Wandel der Zeit

    Energy Technology Data Exchange (ETDEWEB)

    Lich, Mathias [GEA Kueba GmbH, Baierbrunn (Germany)

    2011-08-15

    In the last twenty years, the high performant air cooler has undergone a rapid development. Power, energy efficiency and compact size an important role in the selection for the application in the supermarket. The development of the technology of EC fans shows that there always are potentials for an optimal development of products. While an air cooler needed a current consumption of 180 W for the fan twenty years ago, now significantly less than 100 W are necessary. Fan diameter, pipe diameter, shell size and all incorporated components have become more powerful and more efficient.

  14. Clinical use of 'ROTOP-NEUROSPECT' in several brain diseases. Die klinische Anwendung von 'ROTOP-NEUROSPECT' bei verschiedenen hirnorganischen Erkrankungen

    Energy Technology Data Exchange (ETDEWEB)

    Wuensche, A.; Kaempfer, I.; Loessner, J.; Wagner, A.; Dietrich, J.; Strauss, I.; Neumann, G.; Otto, L.; Koegler, A.; Schenk, S.; Schneider, G. (Leipzig Univ., Klinik fuer Radiologie, Abt. Nuklearmedizin (Germany) Leipzig Univ. (Germany). Klinik fuer Neurologie Leipzig Univ. (Germany). Klinik fuer Neurochirurgie Bezirkskrankenhaus fuer Psychiatrie, Leipzig-Doesen (Germany))

    1990-01-01

    We proofed the suitibility of ROTOP-NEUROSPECT (R*) (HMPAO) from Rossendorf for consideration of disturbed brain circulation in 42 patients. Results we compared with morphological methods (X-ray computing tomography, angiography) and with clinical and neurological findings. We found often a disturbed brain circulation in emission computing tomography (SPECT) before morphological changes in X-ray computing tomography (CT). ROTOP-NEUROSPECT (R*) from Rossendorf is very well for consideration of disturbed brain circulation, we did not see quality differences between ROTOP-NEUROSPECT and CERETEC from Amersham. Activity accumulations in the liver and gall of both radiopharmaceuticals did not influence the test, because of the big distance to the brain. (orig.).

  15. Optimisation of the enforcement of energy regulations and the use of SIA building standards; Optimierung Energievollzug und Anwendung der SIA-Normen Gebaeude

    Energy Technology Data Exchange (ETDEWEB)

    Dettli, R.; Baur, M.; Signer, B. [Econcept AG, Zuerich (Switzerland); Renaud, P.; Wermeille, Ch. [Planair, Bureau d' ingenieurs SIA, La Sagne (Switzerland)

    2003-07-01

    This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study made on the effectiveness of the enforcement of energy legislation and the value of standards in planning and building activities. The reasons for deficiencies in the enforcement of regulations are examined and suggestions are made for improving the situation. Enforcement problems are discussed, including, for example, the partly insufficient capacities at the building authority level. Detailed measures are proposed at the federal and cantonal level and better training and know-how for building professionals is recommended. Those responsible for enforcement - usually the local authorities - are advised to improve the communication of their supervisory activities. Certain improvements to legislation are proposed and professional institutions are motivated to improve quality management and the know-how of their members. The report is completed with a comprehensive list of literature on the subject.

  16. Incentives for development and application of environmentally friendly biotechnological products and processes; Anreize fuer die Entwicklung und Anwendung umweltfreundlicher biotechnischer Produkte und Verfahren

    Energy Technology Data Exchange (ETDEWEB)

    Rhein, Hans-Bernhard; Endler, Katharina [Umweltkanzlei Dr. Rhein, Sarstedt (Germany); Ulber, Roland; Muffler, Kai; Mueller, Felix [Technische Univ. Kaiserslautern (Germany)

    2011-01-15

    Studies assign a tremendous growth potential related to biotechnology. However, the predicted proportion of biotechnological manufactured products in the chemical industry for the year 2010 by 20 % will more likely remain by today's 5 %. The study deals with the question why biotechnological products are currently established at the market in the obvious slow way. Therefore, the current constraints and existing respectively new incentive instruments referring to the white (industrial) biotechnology are analyzed to focus on the promotion of the development and application of environmentally friendly biotechnology products and methods. In addition to a search concerning environmental relevance and further development of white biotechnology, the postulated constraints and incentives as well as new promotions are discussed with the help of expert interviews. On the basis of a preliminary study - after further discussion with experts - concrete proposals on improvements related to an ongoing establishment of biotechnology will be derived. Based on case studies (2nd generation biofuels, polyhydroxybutyrate as biopolymer and phytase as an animal feed additive), the practical effects and specific conditions to incentives, from the perspective of biotechnological processes and environmentally friendly products are investigated. Overall, about 40 activities were recommended, which could be assigned to areas of direct government incentives (tax policy/subsidies, subsidies, education and research policy, basic political conditions, government demand and information policy/consumer intelligence) as well as non-governmental incentives (knowledge transfer and cooperation, organisation-related policy, capital market financing). (orig.)

  17. Application of molecular calcium compounds in catalysis and hydrogen storage; Anwendung von molekularen Calcium-Verbindungen in der Katalyse und der Wasserstoffspeicherung

    Energy Technology Data Exchange (ETDEWEB)

    Spielmann, Jan

    2010-07-20

    1. Applications in catalysis: In the course of this work new catalytic applications of calcium compounds and in particular hydrocarbon-soluble calcium hydride species have been investigated. The complex [(DIPP-nacnac)CaH(THF)]2 (1, DIPP-nacnac = HC[C(Me)N-2,6-(i-Pr)-C6H3]2) served as a model system to test reactivity of the calcium hydride in stoichiometric reactions on a molecular level. It has been found that the hydroboration of conjugated alkenes with catecholborane can be accelerated considerably by using catalytic amounts of calcium complexes. However it was shown that calcium hydride species catalyze the decomposition of catecholborane to BH3 which is probably the catalytically active species. Investigations on the catalytic hydrosilylation of ketones have demonstrated that calcium complexes are efficient catalysts for this reaction. In the proposed catalytic cycle of this reaction six-coordinate hypervalent silicon species play a crucial role. Furthermore it has been shown that molecular calcium compounds are catalysts for the hydrogenation of conjugated alkenes with H2 under relatively mild conditions (20 bar H2, 20 C). Both steps in the proposed catalytical cycle i.e. addition of a metal hydride to the C=C double bond and a heterolytic cleavage of H2 by a calcium alkyl compound have been confirmed experimentally. 2. Applications in hydrogen storage: Ligand stabilized metal amidoborane complexes in the form of (DIPP-nacnac)MNH(R)BH3(THF)x (M = Ca, Mg; R = H, Me, i-Pr, 2,6-(i-Pr)-C6H3; x = 0, 1, 2) have been synthesized and structurally characterized. These complexes are model systems for the metal amidoborane compounds M(NH2BH3)n (M = Li, Na, n = 1; M = Ca, n = 2), which are potential high capacity hydrogen storage materials. To get insights in their dehydrogenation mechanisms the thermal decomposition of the model compounds was investigated in solution. This allowed for the first isolation of well-defined dehydrogenated products which have been structurally characterized. Depending on the metal and the sterical bulk of the substituent R the decomposition resulted in the clean formation of complexes with either a central dianionic [N(R)-BH-N(R)-BH3]2--unit (R = H, Me, i-Pr), a compound containing a borylamide [N(R)=BH2]- (R = 2,6-(i Pr)-C6H3) or a metal hydride complex. For the observed products mechanisms of their formation have been proposed and experimentally confirmed. In these mechanisms metal hydride species play a key role. The favoured decomposition pathway leads to formation of compounds with the central dianionic [N(R)-BH-N(R)-BH3]2--unit. Additionally a magnesium-catalyzed synthetic route to a bis(amino)borane HB[NH(DIPP)]2 has been developed which can form a novel boramidinate ligand {l_brace}HB[N(2,6-(i-Pr)-C6H3)]2{r_brace}2- by double deprotonation. Furthermore a preparative useful synthetic route to zinc and aluminium hydride complexes based on the use of amidoborane compounds has been described. By using novel bis({beta}-diketiminate) ligands it has been possible to prepare dinuclear magnesium amidoborane complexes. The investigation of their thermal decomposition gave important information on aggregation effects of the complexes during the dehydrogenation. As a decomposition product of a N-substituted, dinuclear magnesium amidoborane complex a tetranuclear magnesium hydride complex has been isolated in low yields. Alternatively such compounds have been prepared in good yields by reaction of a n butylmagnesium precursor with phenylsilane. This synthetic approach allowed also the preparation of an octanuclear magnesium hydride complex with a central paddle-wheel shaped [Mg8H10]-unit. These multinuclear magnesium hydride complexes could be considered as ligand-stabilized forms of MgH2 and could be valuable model systems for investigations on MgxHy-hydrogen storage materials. (orig.)

  18. Simulation, optimization, and heuristic in practical application: requirements, state of the art, and development perspectives; Simulation, Optimierung und Heuristik in der praktischen Anwendung: Anforderungen, Stand und Entwicklungsperspektiven

    Energy Technology Data Exchange (ETDEWEB)

    Toelle, F.J.

    1997-12-01

    Process Simulation is routine in chemical engineering and process analysis. This article traces the early developments of process simulation of flowsheeting. Dramatically new expectations and visions are emerging for software tools used in chemical process modeling and simulation. Many companies anticipate a rapid migration of process modeling software to an open architecture. The software components exploit object-oriented pragmatics, including abstraction, encapsulation, inheritance and polymorphism. We discuss the software architecture of tools supporting process synthesis and operations optimization. (orig.) [Deutsch] Als Simulation bezeichnen wir ein experimentelles Vorgehen, bei dem wir bestimmte Eigenschaften eines tatsaechlichen oder auch gedachten technischen, wirtschaftlichen, biologischen Systems nicht am Original selbst, sondern ersatzweise an einem geeigneten Modell des Originals, dem sogenannten Simulator, untersuchen. Bezogen auf die Prozess- und Verfahrenstechnik sind dies primaer funktionelle und systemdynamische Eigenschaften, wie zum Beispiel ein Kraftwerksblock, den wir moeglichst genau dem Original nachbilden. Dabei werden nur jene Aspekte des realen Verhaltens nachgebildet, die vom Modellierer als notwendig erachtet werden. Ein guter Simulator liefert in der Regel eine bequeme und umfassende, zeit- und kostenguenstige, gelegentlich sogar einzige praktikable Moeglichkeit zum Studium aller Betriebszustaende und Eigenschaften des Originals. (orig.)

  19. Development of the microphone array measurement technique for application to cryogenic wind tunnels; Entwicklung der Mikrofonarraymesstechnik fuer die experimentelle Anwendung in kryogenen Windkanaelen

    Energy Technology Data Exchange (ETDEWEB)

    Ahlefeldt, Thomas

    2013-02-01

    The present work deals with the development of the microphone array measurement technique for application to cryogenic wind tunnels at temperatures down to 100 K. In contrast to conventional wind tunnels, in cryogenic wind tunnels the Reynolds number can be changed independent of the Mach number. Therefore the applicability of the microphone array measurement technique to cryogenic wind tunnels allows the independent investigation of Mach and Reynolds number effects for aeroacoustic sources. For this purpose two microphone arrays suitable for cryogenic application have been developed. A small array was used for a validation experiment using a single-rod configuration as an aeroacoustic noise source; the experience gained therefrom being then used to develop a larger array. This array was used to finally demonstrate the applicability of the measuring technology to an airplane half model. For the development of both arrays several factors had to be considered, such as, for example, the contraction arising from the low temperatures and the influence of the temperature on the microphone frequency response. In the validation experiment, acoustic array measurements have been performed using the small microphone array with 21 microphones in a cryogenic wind tunnel for various Mach and Reynolds numbers, using a single-rod configuration. The aeroacoustic source induced by the rod could be identified by the microphone.array at ambient as well as at cryogenic temperatures. The radiated sound powers were compared with predictions from two models: one model was based on a dimensional analysis of the measured data without taking into consideration the Reynolds number. The measured data with this model could be better fitted by a speed law with the exponent 6.7 rather than the expected 6.0. The second model was based on an analytical model for sound radiation from a single-rod configuration which took into account variables dependent on the Reynolds number. The comparison with this model showed very good agreement in that the u{sup 6} power law was shown to apply. The important outcome of this validation experiment was that the data measured in the cryogenic environment let to meaningful experimental results. In the demonstration experiment the sound radiation of an airplane half model in a high-lift configuration in a cryogenic wind tunnel was examined with a large microphone array, which consisted of 144 microphones. Aeroacoustic sources were localised at ambient as well as at cryogenic temperatures on different areas of the wing, such as, for example, at the leading edge flap, the trailing flap tip or the Krueger's flap. The radiated sound showed a dependence on the Reynolds number for the whole model as well as for different source areas. This was in particular the case for two source areas: First, dominant tones were identified in the vicinity of the leading edge, but which then disappeared with a rise of the Reynolds number. Second, a narrow band source could be seen on the turbulence generator on the nacelle, for which a scaling to the Mach number with M{sup 6} and a systematic dependence on the Reynolds- and Strouhal numbers could be shown. To sum up, the results of the investigation on the half model demonstrated successfully the applicability of the measurement technique developed within the scope of this work.

  20. Shared technologies in the development of the Titan 250 trademark gas turbine system; Anwendung bewaehrter Technologien bei der Entwicklung des Titan 250 trademark Gasturbinensystems

    Energy Technology Data Exchange (ETDEWEB)

    Stang, Ulrich; Knodle, Mark; Novaresi, Mark [Solar Turbines, Inc., San Diego, CA (United States); Ottoboni, Luigi [Turbomach SA, Riazzino (Switzerland)

    2010-07-01

    The Titan 250 gas turbine and C85 centrifugal gas compressor are the latest additions to the Solar Turbines product family. These new products leverage core technologies that have been developed and proven in several other well-established products. The Titan 250 gas turbine is a conservative hybrid design grounded in advanced aerodynamic, thermal and mechanical design tools and methodologies. It is ISO rated at 22.4 MW (30,000 HP), with a best-in-class shaft efficiency of 40% reducing fuel costs and emissions. The engine is a two-shaft design that includes a 16-stage axial flow compressor (PR 24:1), a dry low emissions combustor (<15 ppmv NOx), a two-stage gas producer turbine operating at a firing temperature of 1200 C (2200 F), and a three-stage, maximum efficiency, fully shrouded power turbine. (orig.)

  1. Codoped emission layers for the application in white, organic light-emitting diodes; Kodotierte Emissionsschichten zur Anwendung in weissen, organischen Leuchtdioden

    Energy Technology Data Exchange (ETDEWEB)

    Steinbacher, Frank

    2012-07-01

    In this dissertation, the first step towards an application of mixed emission layers in highly efficient white OLEDs is an investigation of the underlying exciton transfer process. Simple, solution processable samples of dispersed phosphorescent dye molecules in a PMMA matrix are investigated by (time-resolved) photoluminescence. An optimized yellow OLED acts as a starting point for the use of a mixed emission layer in highly efficient white OLEDS. Although some adaptation of existing layouts is needed, it is possible to introduce mixed emission layers into regular as well as stacked white diode concepts. An evaporation technique which uses a combination of two dyes in one crucible is tested for its applicability. Although rate detection can be simplified in that way, different evaporation properties of the materials lead to a continuously changing composition in the mixed crucible. In summary, the fundamental exciton transfer process in mixed emission layers was investigated and explained in simple setups as well as complete OLEDs. (orig.)

  2. Application of the in-beam PET therapy monitoring on precision irradiations with helium ions; Anwendung des in-beam PET Therapiemonitorings auf Praezisionsbestrahlungen mit Helium-Ionen

    Energy Technology Data Exchange (ETDEWEB)

    Fiedler, F.

    2008-02-19

    The main goal of the present dissertation was to extend the in-beam PET method to new ion types. It was shown that the in-beam PET method can also be applied for {sup 3}He irradiations. For this experiments on a {sup 3}He beam were performed. The activity yield is at equal applied dose about three times larger than at {sup 12}C irradiations. The reachable range resolution is smaller than 1 mm. At the irradiation of an inhomogeneous phantom it was shown that a contrast between different materials is resolvable. From the experimentally determined reaction rates cross sections for the reactions leading to positron emitters were performed. The data taken in the {sup 3}He experiments were compared those obtained in carbon-ion experiments as well as literature data for proton irradiations. A comparison with the calculations of the simulation program SHIELD-HIT was performed. A collection of cross-section models and the established requirements for a simulation program applicable for in-beam PET are preparing for further work.

  3. Recommendation for the application of the guideline for incorporation monitoring in nuclear medicine; Empfehlung fuer die Anwendung der Richtlinie zur Inkorporationsueberwachung in der Nuklearmedizin

    Energy Technology Data Exchange (ETDEWEB)

    Schoenmuth, T. [Verein fuer Kernverfahrenstechnik und Analytik Rossendorf e.V. (VKTA), Dresden (Germany); Dalheimer, A. [Bundesamt fuer Strahlenschutz (Germany); Eckardt, J. [Universitaetsklinikum Muenster (Germany); Eschner, W. [Universitaetsklinikum Koeln (Germany); Kratzel, U. [LfU Bayern (Germany); Lassmann, M. [Universitaetsklinikum Wuerzburg (Germany); Lauterbach, H. [Universitaetsklinikum Jena (Germany); Dettmann, K.

    2009-07-01

    For the use of open radioactive materials in the nuclear medicine a recommendation should give assistance by the judgement of the draught suggested by the user according to the guideline 'Incorporation monitoring' to the responsible authorities. To the evaluation of the requirement for a regular monitoring the document delivers recommendations for incorporation factors or use of threshold value measurements. (orig.)

  4. sup 123 I-tyrosine-(A14)-insulin: preparation and preliminary clinical studies. sup 123 I-tyrosin-(A14)-Insulin: Entwicklung und erste klinische Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Pantev, T; Virgolini, I; Sinzinger, H; Prager, R; Neuhold, N; Angelberger, P; Banyai, M; Knoebl, P [Oesterreichisches Forschungszentrum Seibersdorf GmbH (Austria). Inst. fuer Chemie Vienna Univ. (Austria). Abt. fuer Nuklearmedizin

    1991-01-01

    Insulin was radioiodinated with {sup 123}I ({sup 123}I-tyrosine-(A14)-insulin) to a specific activity of 1 {mu}g/mCi, corresponding to 0.025 I.U. of insulin/mCi. This preparation was used for in vitro binding experiments with adipose tissue, showing active binding to the two subunits of the known insulin receptor. In a preliminary clinical investigation, 5 adipose patients with (n = 2) and without (n = 3) diabetes mellitus Type II, were subject to in vivo injection of the same radiolabeled product using 3 mCi/patient. During the first minutes of dynamic imaging, the liver was the major organ of tracer uptake in all patients. Furthermore, the pancreas, and in one patient the kidneys, were visualised. Further studies on insulin in vivo kinetics and quantification are under way. (authors).

  5. Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer. Dosimetrical comparison and clinical feasibility in 20 patients

    Energy Technology Data Exchange (ETDEWEB)

    Hepp, Rodrigo; Ammerpohl, Mark; Morgenstern, Christina; Erichsen, Patricia [Evangelische Kliniken Gelsenkirchen, Klinik fuer Strahlentherapie und Radioonkologie, Gelsenkirchen (Germany); Nielinger, Lisa [Evangelische Kliniken Gelsenkirchen, Klinik fuer Strahlentherapie und Radioonkologie, Gelsenkirchen (Germany); Hochschule Hamm-Lippstadt, Lippstadt (Germany); Abdallah, Abdallah [Evangelische Kliniken Gelsenkirchen, Klinik fuer Senologie, Gelsenkirchen (Germany); Galalae, Razvan [Evangelische Kliniken Gelsenkirchen, Klinik fuer Strahlentherapie und Radioonkologie, Gelsenkirchen (Germany); Christian-Albrechts-Universitaet zu Kiel, Medizinische Fakultaet, Kiel (Germany)

    2015-09-15

    Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients' acceptance/compliance and associated additional workload. Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 cm{sup 3} (D{sub 2} {sub cm} {sup 3}), volume receiving ≥ 5 Gy (V{sub 5}), 10 Gy (V{sub 10}), 15 Gy (V{sub 15}) and 20 Gy (V{sub 20}). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart D{sub 2} {sub cm} {sup 3} was less than 42 Gy in DIBH. In FB the heart D{sub 2} {sub cm} {sup 3} was ≥ 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL. (orig.) [German] Die adjuvante Strahlentherapie nach brusterhaltener Operation (BCS) bei Brustkrebs (BC) ist eine seit langem anerkannte Behandlungsform. Das postradiogene Risiko einer kardialen Ischaemie steigt linear ohne erkennbaren Schwellenwert mit der mittleren Herzdosis. Die Bestrahlung der linken Brust in tiefer Inspiration unter Anhalten der

  6. High-precision radiotherapy for meningiomas. Long-term results and patient-reported outcome (PRO)

    Energy Technology Data Exchange (ETDEWEB)

    Kessel, Kerstin A.; Fischer, Hanna; Combs, Stephanie E. [Technical University of Munich (TUM), Department of Radiation Oncology, Munich (Germany); Helmholtz Zentrum Muenchen (HMGU), Institute for Innovative Radiotherapy (iRT), Department of Radiation Sciences DRS, Neuherberg (Germany); Oechnser, Markus [Technical University of Munich (TUM), Department of Radiation Oncology, Munich (Germany); Zimmer, Claus [Technical University of Munich (TUM), Department of Neuroradiology, Munich (Germany); Meyer, Bernhard [Technical University of Munich (TUM), Department of Neurosurgery, Munich (Germany)

    2017-11-15

    ) durchgefuehrt, bei 241 eine fraktionierte stereotaktische Strahlentherapie (FSRT) und bei 18 eine intensitaetsmodulierte Strahlentherapie (IMRT). Fuer die Patientenselbstauskunft wurden 218 Patienten kontaktiert, 207 antworteten (95 %). Die mediane Nachsorgedauer betrug 7,2 Jahre. Fuer gutartige Meningeome war das Gesamtueberleben (OS) nach 3, 5, 10 und 15 Jahren 97 %, 94 %, 85 % und 64 %; fuer atypische Meningeome betrug es zu diesen Zeitpunkten 91 %, 86 %, 62 % und 50 %. Die lokale Kontrolle (PFS) fuer benigne Meningeome nach 3, 5 und 10 Jahren war 91 %, 87 % und 86 %, fuer atypische Faelle 67 % und 55 % nach 3 und 5 Jahren. Nur 3 % der Patienten gaben neue oder verschlechterte Beschwerden ≥ 3 (CTCAE) waehrend und innerhalb der ersten 6 Monate nach RT an; 17,5 % berichteten von einer Verschlechterung nach ueber 2 Jahren. Tumorvolumen und Patientenalter zeigten signifikanten Einfluss auf OS und PFS. Wir konnten anhand der Untersuchung die langfristig gute Vertraeglichkeit bei gleichzeitig exzellenter lokaler Kontrolle bestaetigen. Durch das guenstige Risiko-Nutzen-Verhaeltnis sollte auch bei gutartigen hoehergradigen Meningeomen eine RT als adjuvante Therapie durchgefuehrt und nicht bis zur Tumorprogression aufgeschoben werden. (orig.)

  7. Analysis of dose in heterogeneity adjuvant radiotherapy after surgical treatment of cases of breast cancer; Analise da heterogeneidade de dose em radioterapia adjuvante apos tratamento cirurgico de casos de cancer de mama

    Energy Technology Data Exchange (ETDEWEB)

    Grechi, Bruna E.; Schwarz, Ana Paula, E-mail: anapaulaschwarz@yahoo.com.br [Centro Universitario Franciscano (UNIFRA), Santa Maria, RS (Brazil); Teston, Adriano; Rodrigues, Joanilso S. [Clinica de Radioterapia Santa Maria, Santa Maria, RS (Brazil)

    2013-12-15

    Assuming the systems planning radiotherapy recognize all body structures of the same density (d=1 g/cm³), variations in electron density within the irradiated area, as is the case of patients who undergo reconstruction mammary processes and use tissue expanders, may influence the dose distribution in the treatment and may produce heterogeneities which are not measured by changing its actual distribution into healthy tissues or in the target volume to be irradiated. Through the calculation of the algorithms' dose distribution of the XiO® planning system (Fast Fourier Transform, Convolution, Superposition, Fast Superposition e Clarkson), when using correction of heterogeneity between tissues of different densities, there was obtained a percentage ratio of dose increase in the structures of interest, and of the amount of absorbed dose by healthy organs adjacent to the target volume. (author)

  8. O uso da L-carnitina como adjuvante no tratamento da miocardiopatia dilatada em criança com Aids Usage of L-carnitine as adjuvant in the treatment of dilated cardiomyopathy in a child with Aids

    Directory of Open Access Journals (Sweden)

    Lourdes Zélia Zanoni

    2011-06-01

    Full Text Available OBJETIVO: Apresentar a resposta cardiovascular à L-carnitina de um paciente com insuficiência cardíaca congestiva decorrente de miocardiopatia dilatada pelo vírus da imunodeficiência humana. DESCRIÇÃO DO CASO: Criança com quadro clínico de insuficiência cardíaca congestiva grave devido à miocardiopatia dilatada pela síndrome de imunodeficiência adquirida. O tratamento para as manifestações clínicas foi instituído, com pouca resposta clínica. Com objetivo de melhorar o desempenho energético/metabólico dos cardiomiócitos, foi instituída terapia com L-carnitina. Observou-se significativa melhora clínica do paciente, em relação ao desempenho cardíaco, mesmo antes do início do tratamento com os fármacos antirretrovirais. COMENTÁRIOS: A L-carnitina é um composto que facilita o transporte dos ácidos graxos de cadeia longa para dentro da mitocôndria. Nesse caso, o uso da L-carnitina parece ser clinica e bioquimicamente justificado.OBJECTIVE: To present the cardiovascular response to L-carnitine of a patient with congestive heart failure caused by dilated cardiomyopathy and human immunodeficiency virus. CASE DESCRIPTION: Child with a clinical history of severe congestive heart failure due to dilated cardiomyopathy caused by acquired immunodeficiency syndrome. The treatment for the symptoms resulted in a poor clinical response. In order to improve the energetic performance/metabolism of cardiomyocytes, therapy with L-carnitine was established. There was significant clinical improvement of the cardiac performance of the patient, even before starting the treatment with antiretroviral drugs. COMMENTS: L-carnitine is a compound that facilitates the transport of long-chain fatty acids into the mitochondria. In this case the administration of L-carnitine appears to be clinically and biochemical justified.

  9. Locoregional recurrence of rectal carcinoma. A CT-analysis and a target volume concept in adjuvant radiotherapy; Das lokoregionaere Rezidiv des Rektumkarzinoms. Eine computertomographische Analyse und ein Zielvolumenkonzept fuer die adjuvante Radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Bagatzounis, A. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Koelbl, O. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Mueller, G. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Oppitz, U. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Willner, J. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Flentje, M. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie

    1997-02-01

    Patients and method: 155 patients with the diagnosis of rectal carcinoma recurrences were treated in our institution between 1980 and 1995. To determine the extension of the recurrent tumor within the pelvic levels (praesacral levels S1-S5, precoccygeal-, pelvic floor level and perineal level) and the tumor infiltration of pelvic organs and muscles we analysed the pretherapeutic CT-images. The lymphnode recurrences were classified as: Pararectal-, presacral-, iliac internal-, iliac external-, iliac communis- and paraaortal recurrences. Results: Sixty-one percent of the patients with rectum exstirpation and 66% with anterior resection showed a combined local and nodal recurrence. Isolated lymph node recurrences were rare (4% and 5%). The local recurrence was mostly situated in the presacral pelvis, predominantly there was an infiltration of the presacral space at the level of S4, S5 and os coccygis regardless of the operating method and the primary tumor location. The anastomosis was involved in the tumor recurrence in 93% of the anteriorly resected patients. In 9 out of 96 patients after rectum exstirpation the pelvic region caudal of the tip of the coccyx was the origin of the recurrent tumor. Primarily all 9 patients had a deep-seated carcinoma (<6 cm ab ano). Only 2 patients showed an isolated perineal recurrence after rectum exstirpation. Two thirds of the deepseated tumors showed a vaginal involvement. The incidence of iliac internal- and presacral nodal recurrence was 47 to 59%. The incidence of iliac external lymph node recurrences was 7% after rectum exstirpation and 2% after anterior resection/Hartmann procedure. (orig./AJ) [Deutsch] Patienten und Methode: 155 Patienten wurden in unserer Klinik im Zeitraum 1980 bis 1995 wegen eines Rektumkarzinomrezidivs behandelt. Die Rezidivausdehnung innerhalb der Beckenetagen (Sakralsegmente S1 bis S5, praekokzygeal, Beckenbodenetage und perineales Weichgewebe) und die Infiltration von Beckenorganen und Muskelgruppen wurden anhand der Kontrastmittel-CT ermittelt. Die Lymphknotenrezidive wurden unterteilt in: pararektale, praesakrale, Iliaca-interna-, Iliaca-externa, Iliaca-communis- und paraaortale Rezidive. Ergebnisse: Bei 61% der Patienten nach Rektumexstirpation und bei 66% nach anteriorer Resektion wurde ein kombiniertes Tumorbett-/Lymphknotenrezidiv festgestellt. Isolierte Lymphknotenrezidive waren selten (4% bzw. 5%). Sowohl nach Rektumexstirpation als auch nach anteriorer Resektion und Hartmann-Operation waren die Tumorbettrezidive am haeufigsten im Praesakralraum lokalisiert. Unabhaengig von der Operationsmethode und dem Primaertumorsitz fand sich meist eine Infiltration des Praesakralraums in Hoehe S4 bis zum Steissbein (Inzidenz 65% bis 86%). Nach anteriorer Resektion war die Anastomose in 93% der Faelle ins Rezidivgeschehen involviert. Die Beckenbodenetage kaudal der Steissbeinspitze war bei 9 der 96 Patienten nach Rektumexstirpation der Ausgangsort des Rezidivs. Alle 9 Patienten hatten initial einen tiefsitzenden Tumor (unterhalb 6 cm). Ein isoliertes perineales Rezidiv wurde bei nur 2 Patienten nach Rektumexstirpation festgestellt. Bei tiefsitzenden Tumoren und nach Rektumexstirpation war die Vagina in 2 Drittel der Faelle infiltriert. Die Inzidenz der Iliaca-interna-, pararektalen und praesakralen Lymphknotenrezidive war 47 bis 59%. Die Inzidenz der Iliaca-externa-Lymphknotenrezidive betrug 7% nach Rektumexstirpation und 2% nach anteriorer Resektion/Hartmann-Operation. (orig./AJ)

  10. Prospective and comparative assessment of toxicity of adjuvant concomitant chemo-radiotherapy after neo-adjuvant chemotherapy in breast cancer; evaluation prospective et comparative de la toxicite de la chimioradiotherapie concomitante adjuvante apres chimiotherapie neoadjuvante dans le cancer du sein

    Energy Technology Data Exchange (ETDEWEB)

    Marchand, V.; Angelergues, A.; Gobaux, V.; Kirova, Y.M.; Campana, F.; Dendale, R.; Reyal, F.; Pierga, J.Y.; Fourquet, A.; Bollet, M.A. [Institut Curie, Paris (France)

    2011-10-15

    The authors report a prospective assessment of toxicity a treatment comprising an adjuvant chemo-radiotherapy after neo-adjuvant chemotherapy and a comparison with a treatment comprising only radiotherapy. Two sets of patients have been treated for a breast cancer between 1997 and 2002 by association of neo-adjuvant chemotherapy, surgery and radiotherapy with or without concomitant chemotherapy. Late toxicity has been assessed prospectively according to Common Terminology Criteria for Adverse Events. Acute toxicity has been noticed in medical files. The analysis of 142 treatments reveals that the concomitant administration of chemotherapy to radiotherapy after neo-adjuvant chemotherapy and surgery is associated with an increase of acute toxicity without increase of long term toxicity. Short communication

  11. Dioxines, furans and other pollutants emissions bond to the combustion of natural and additive woods; Facteurs d'emission. Emissions de dioxines, de furanes et d'autres polluants liees a la combustion de bois naturels et adjuvantes

    Energy Technology Data Exchange (ETDEWEB)

    Collet, S

    2000-02-15

    This report deals especially on the dioxines and furans bond to the combustion of wood in industrial furnaces and domestic furnaces. It aims to define the environmental strategy which would allow the combustion of wood residues to produce energy. The first part recalls general aspects concerning the wood. The six other parts presents the wood resources and wastes, the additive used, the combustion and the different factors of combustion and finally the pollutants emissions. (A.L.B.)

  12. German S3 guideline for renal cell carcinoma. Presentation and discussion of essential aspects for the radiation oncologist; Die deutsche S3-Leitlinie zum Nierenzellkarzinom. Darstellung und Diskussion wesentlicher Aspekte fuer den Radioonkologen

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Arndt-Christian [Eberhard Karls University, Department of Radiation Oncology, Tuebingen (Germany); Oorschot, Birgitt van [Julius Maximilians University, Department of Radiation Oncology, Wuerzburg (Germany); Micke, Oliver [Franziskus Hospital Bielefeld, Department of Radiotherapy and Radiation Oncology, Bielefeld (Germany); Guckenberger, Matthias [University of Zurich, Department of Radiation Oncology, Zuerich (Switzerland)

    2018-01-15

    ) Primaersituation - neoadjuvante/adjuvante Therapie: Keine radiotherapeutische Indikation. (2) Primaersituation - ''small renal mass''/fokale Therapie: Stereotaktisch-ablative Radiotherapie derzeit fallzahlbedingt noch als experimentell eingestuft, bei jedoch hoher Effektivitaet mit lokaler 2-Jahres-Tumorkontrolle von >90 %. (3) Oligometastasierung: Hoeherdosierte Radiotherapie/Stereotaxie interdisziplinaer anbieten. Hinsichtlich der palliativen Situation (4) und der symptomatischen Behandlung (5) gelten die gleichen Grundsaetze wie fuer andere Entitaeten. Fuer die Strahlentherapie gibt es derzeit keine Indikation in der Primaertherapie des Nierentumors (adjuvant, neoadjuvant, definitiv). In der Zukunft sollte aufgrund der guenstigen therapeutischen Breite die stereotaktische Bestrahlung eine wichtigere Rolle in der Therapie inoperabler Patienten mit einem primaeren Nierenzellkarzinom sowie in der Situation der Oligometastasierung einnehmen. (orig.)

  13. Das Alter ist der wichtigste Risikofaktor der postoperativen erektilen Dysfunktion nach radikaler nerverhaltender Prostatektomie

    Directory of Open Access Journals (Sweden)

    Gruschka M

    2009-01-01

    Full Text Available Die radikale Prostatektomie ohne Nerverhalt geht mit Impotenz einher. Bei nerverhaltendem Vorgehen kann das Risiko der erektilen Dysfunktion gesenkt, aber nicht ausgeschlossen werden. Die präoperative Beratung der Patienten erfordert bei nerverhaltender Prostatektomie die Kenntnis der Faktoren, die Einfluss auf die postoperative Potenz haben. Patienten & Methoden: 110 Patienten antworteten 24 Monate nach radikaler perinealer nerverhaltender Prostatektomie auf einen per Post übermittelten Fragebogen. Die Patienten wurden, entsprechend dem Erection Hardness Score, nach der Rigidität ihrer Erektionen befragt. Überwiegend erfolgte der Nerverhalt unilateral (104/110. Verschiedene potenzielle Risikofaktoren (Alter, Qualität der präoperativen Erektion, Serum-PSA, Gleason-Score, Tumorvolumen, Prostatavolumen, adjuvante Strahlentherapie, ASA-Score, Chronic Disease Score [CDS], arterielle Hypertonie, Hypercholesterinämie, Diabetes mellitus, KHK, Nikotinkonsum wurden univariat mit der postoperativ erzielten Potenz korreliert. Multivariat wurden dann jene Parameter untersucht, die in der univariaten Analyse einen signifikanten (p ≤ 0,05 oder einen tendenziellen Zusammenhang (p ≤ 0,2 mit der postoperativen erektilen Funktion aufwiesen. Ergebnisse:Das Alter (p 0,001 und der ASAScore (p = 0,018 waren in der univariaten Analyse negative Prädiktoren der postoperativen Potenz. In der multivariaten Analyse war lediglich das Alter (p = 0,028 von signifikanter Bedeutung. Mit jedem Lebensjahr der Männer steigt das Risiko einer um eine Stufe im EHS schlechteren Erektion um das 1,128-Fache an. Bei einem Altersunterschied von 10 Jahren ist das Risiko eines postoperativ schlechteren Erektionsvermögens um den Faktor 3,334 erhöht, bei einem um 20 Jahre höheren Alter beträgt dieser Faktor 11,121. Diskussion & Praxisrelevanz: Das Lebensalter der Patienten wurde im Einklang mit der Literatur als signifikanter Faktor für die postoperative Potenz identifiziert

  14. Intensity-modulated radiotherapy for localized nasopharyngeal amyloidosis. Case report and literature review

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Ming [Hubei University of Medicine, Department of Clinical Oncology, Taihe Hospital, Shiyan, Hubei (China); Peng, Gang; Shi, Liangliang; Li, Zhenyu; Fei, Shijiang; Ding, Qian; Cheng, Jing [HuaZhong University of Science and Technology, Cancer Center, Union Hospital, Tongji Medical College, Wuhan (China); Ming, Xing [Hubei University of Medicine, Department of infection control and prevention, Taihe Hospital, Shiyan, Hubei (China)

    2016-12-15

    Bedeutung. Bei einem 39-jaehrigen Patienten mit seit einigen Wochen bestehenden Symptomen nasaler Obstruktion und Nasenbluten zeigten Computer- (CT) und Magnetresonanztomographie (MRT) einen hinter dem Dens liegenden Weichteiltumor ohne Enhancement. Die endoskopisch gewonnene Biopsie zeigte, dass es sich bei dem Tumor um eine Amyloidose handelte. Eine umfassende Diagnostik ergab keine entzuendlichen Prozesse, keine systematische Amyloidose und keine Plasmazell-Dyskrasie. Der Patient wurde kombiniert chirurgisch und strahlentherapeutisch behandelt. In der 1-Jahr-Follow-up-Untersuchung fand sich kein Hinweis fuer ein Rezidiv bzw. einen Progress. Die primaere solitaere Amyloidose ist eine seltene Amyloidoseform. Unseres Wissens ist dies der erste Bericht eines Patienten mit nasopharnygealer Amyloidose, der kombiniert chirurgisch und strahlentherapeutisch behandelt wurde und bei dem eine vollstaendige Remission erzielt wurde. Wegen der schwierig zu erreichenden radikalen Resektion bei Laesionen in diesem Bereich hat sich die Strahlentherapie fuer den vorgestellten Patienten als ausgezeichnete adjuvante Behandlungsoption erwiesen. (orig.)

  15. Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer. Results of a prospective study

    Energy Technology Data Exchange (ETDEWEB)

    Tribius, Silke; Raguse, Marieclaire; Voigt, Christian; Petersen, Cordula; Kruell, Andreas [University Medical Center Hamburg-Eppendorf, Department of Radiation Oncology, Hamburg (Germany); Muenscher, Adrian [University Medical Center Hamburg-Eppendorf, Department of Otorhinolaryngology and Head and Neck Surgery, Hamburg (Germany); Groebe, Alexander [University Medical Center Hamburg-Eppendorf, Department of Maxillofacial Surgery, Hamburg (Germany); Bergelt, Corinna [University Medical Center Hamburg-Eppendorf, Department of Medical Psychology, Hamburg (Germany); Singer, Susanne [University Medical Center Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Mainz (Germany)

    2015-03-08

    Patients with locally advanced head and neck cancer (LAHNC) undergo life-changing treatments that can seriously affect quality of life (QoL). This prospective study examined the key QoL domains during the first year after intensity-modulated radiotherapy (IMRT) and identified predictors of these changes in order to improve patient outcomes. A consecutive series of patients with LAHNC completed the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core module (QLQ-C30) and the HNC-specific QLQ-HN35 before (t0) and at the end (t1) of definitive or adjuvant IMRT, then at 6-8 weeks (t2), 6 months (t3), and 1 year (t4) after IMRT. Patients (n = 111) completing questionnaires at all five time points were included (baseline response rate: 99 %; dropout rate between t0 and t4: 5 %). QoL deteriorated in all domains during IMRT and improved slowly during the first year thereafter. Many domains recovered to baseline values after 1 year but problems with smelling and tasting, dry mouth, and sticky saliva remained issues at this time. Increases in problems with sticky saliva were greater after 1 year in patients with definitive versus adjuvant IMRT (F = 3.5, P = 0.05). QoL in patients with LAHNC receiving IMRT takes approximately 1 year to return to baseline; some domains remain compromised after 1 year. Although IMRT aims to maintain function and QoL, patients experience long-term dry mouth and sticky saliva, particularly following definitive IMRT. Patients should be counseled at the start of therapy to reduce disappointment with the pace of recovery. (orig.) [German] Die Therapie von Patienten mit lokal fortgeschrittenen Kopf-Hals-Tumoren (LFKHT) geht mit einschneidenden Veraenderungen einher und beeinflusst die Lebensqualitaet (LQ) erheblich. Diese prospektive Studie untersucht die LQ waehrend des ersten Jahres nach intensitaetsmodulierter Strahlentherapie (IMRT) und hat Praediktoren dieser Veraenderungen herausgearbeitet, um

  16. Bibliometrics of intraoperative radiotherapy. Analysis of technology, practice and publication tendencies

    Energy Technology Data Exchange (ETDEWEB)

    Sole, Claudio V. [Instituto de Radiomedicina, Service of Radiation Oncology, Santiago (Chile); School of Medicine Complutense University, Madrid (Spain); Institut Gustave Roussy, Department of Radiation Oncology, Paris (France); Calvo, Felipe A. [School of Medicine Complutense University, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Department of Oncology, Madrid (Spain); Hospital General Universitario Gregorio Maranon, Institute for Sanitary Research, Madrid (Spain); Ferrer, Carlos [Hospital Provincial de Castellon, Institute of Oncology, Castellon de la Plana (Spain); Cardenal Herrera-CEU University, School of Medicine, Castellon de la Plana (Spain); Pascau, Javier [Hospital General Universitario Gregorio Maranon, Institute for Sanitary Research, Madrid (Spain); Marsiglia, Hugo [Institut Gustave Roussy, Department of Radiation Oncology, Paris (France)

    2014-12-15

    To analyze the performance and quality of intraoperative radiation therapy (IORT) publications identified in medical databases during a recent period in terms of bibliographic metrics. A bibliometric search was conducted for IORT papers published in the PubMed database between 1997 and 2013. Publication rate was used as a quantity indicator; the 2012 Science Citation Index Impact Factor as a quality indicator. Furthermore, the publications were stratified in terms of study type, scientific topic reported, year of publication, tumor type and journal specialty. We performed a one-way analysis of variance (ANOVA) to determine differences between the means of the analyzed groups. Among the total of 207 journals, articles were reported significantly more frequently in surgery (n = 399, 41 %) and radiotherapy journals (n = 273, 28 %; p < 0.01). The highest impact factor was achieved by clinical oncology journals (p < 0.01). The majority of identified articles were retrospective cohort reports (n = 622, 64 %), followed by review articles (n = 204, 21 %; p < 0.001). Regarding primary topic, reports on cancer outcome following specific tumor therapy were most frequently published (n = 661, 68 %; p < 0.001) and gained the highest mean impact factor (p < 0.01). Gastrointestinal tumor reports were represented most frequently (n = 456, 47 %; p < 0.001) and the mean superior impact factor was earned by breast and gynecologic publications (p < 0.01). We identified a consistent and sustained scientific productivity of international IORT expert groups. Most publications appeared in journals with surgical and radiooncological content. The highest impact factor was achieved by medical oncology journals. (orig.) [German] Ziel war es, in Form von bibliographischen Metriken die wissenschaftliche Effizienz und Qualitaet von Publikationen ueber die Anwendung intraoperativer Strahlentherapie (IORT) zu analysieren, die in einer bestimmten Zeitspanne in medizinischen Datenbanken gefunden

  17. Principles and concept 1993 of the systemic cancer multistep therapy (sCMT). Extreme whole-body hyperthermia using the infrared-A technique IRATHERM 2000 - selective thermosensitisation by hyperglycemia - circulatory back-up by adapted hyperoxemia

    Energy Technology Data Exchange (ETDEWEB)

    Ardenne, M. von [Von Ardenne Inst. of Applied Medical Research, Dresden (Germany)

    1994-10-01

    , Hyperoxaemie und der optionalen Anwendung einer moderaten Chemotherapie sowie einer Strahlentherapie mit verringerter Strahlendosis. Es unterscheidet sich von den vorangegangenen sKMT-Konzepten 1974 und 1977 in Dosis und Timing sowie im Fortschritt der Hyperthermietechnik. Nach Abschluss der sKMT schliesst sich eine etwa 24stuendige intensivstationaere-Nachbeobachtung des Patienten an, bevor er in die ambulante Nachbetreuung entlassen wird. Die systemische Toleranz der sKMT mit nur minimalen Nebenwirkungen konnte an mehreren 100 Patienten nachgewiesen werden und ist im Rahmen einer Phase-I-Studie veroeffentlicht worden. Eine erste Bewertung der Wirksamkeit der sKMT ist der gleichen Arbeit zu entnehmen. (orig.)

  18. Successful treatment of chronic recurrent multifocal osteomyelitis using low-dose radiotherapy. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Dietzel, Christian T.; Vordermark, Dirk [Klinikum der Martin-Luther-Universitaet Halle-Wittenberg, Universitaetslinik und Poliklinik fuer Strahlentherapie, Halle (Saale) (Germany); Schaefer, Christoph [Klinikum der Martin-Luther-Universitaet Halle-Wittenberg, Universitaetsklinik und Poliklinik fuer Innere Medizin II, Halle (Saale) (Germany)

    2017-03-15

    Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disease, which lacks an infectious genesis and predominantly involves the metaphysis of long bones. Common treatments range from nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids at first onset of disease, to immunosuppressive drugs and bisphosphonates in cases of insufficient remission. The therapeutic use of low-dose radiotherapy for CRMO constitutes a novelty. A 67-year-old female patient presented with radiologically proven CRMO affecting the right tibia/talus and no response to immunosuppressive therapy. Two treatment series of radiation therapy were applied with an interval of 6 weeks. Each series contained six fractions (three fractions per week) with single doses of 0.5 Gy, thus the total applied dose was 6 Gy. Ten months later, pain and symptoms of osteomyelitis had completely vanished. Radiotherapy seems to be an efficient and feasible complementary treatment option for conventional treatment refractory CRMO in adulthood. The application of low doses per fraction is justified by the inflammatory pathomechanism of disease. (orig.) [German] Die chronisch rekurrierende multifokale Osteomyelitis (CRMO) ist eine seltene autoimmunologische Erkrankung und befaellt vorzugsweise die Metaphysen der langen Roehrenknochen. Die Therapie umfasst nichtsteroidale Antirheumatika (NSAIDs) und Kortikosteroide bei Erstbefall und reicht bis hin zu Immunsuppressiva und Bisphosphonaten bei insuffizientem Ansprechen. Die Anwendung einer niedrigdosierten Radiatio stellt ein therapeutisches Novum dar. Eine 67-jaehrige Patientin stellte sich mit einem radiologisch gesicherten Befall im Sinne einer CRMO im Bereich des rechten Talus und der Tibia vor. Eine initiale Behandlung mit Immunsuppressiva verblieb erfolglos. Wir fuehrten zwei Bestrahlungsserien im Intervall von 6 Wochen durch. Jede Serie bestand aus 6 Fraktionen (3 Fraktionen/Woche), mit einer Einzeldosis von jeweils 0,5 Gy. Die

  19. Sentinel node concept in breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kiricuta, I.C. [St. Vincenz-Hospital, Limburg (Germany). Inst. for Radiation Oncology

    2000-07-01

    Praediktor. Die maximale Aufarbeitung des Sentinel Node ist die Voraussetzung des Erfolgs des Sentinel-Node-Konzepts. Eine hohe Erfolgsrate dieses Vorgehens ist auch von der funktionellen Kapazitaet des Lymphknotens abhaengig. Auf eine komplette Axilladissektion bei einem negativen Sentinel-Lymphknoten koennte man verzichten. Bei einem klinisch negativen Befund und Sentinel-Node-positiven Status koennte auch eine alleinige Strahlentherapie ausreichend sein. Eine TNM-Klassifikation fuer das Sentinel-Node-Konzept wurde empfohlen. Neue Zielvolumenbestimmungen fuer die adjuvante Strahlentherapie beim Mammakarzinom sind mit Hilfe des Sentinel-Node-Konzepts moeglich. Schlussfolgerungen: Das Sentinel-Node-Konzept wird die adjuvante Behandlung des Mammakarzinoms beeinflussen. Die Sentinel-Node-Biopsie ist ein sehr akkurates Verfahren, minimalinvasiv und mit einer hohen Erfolgsrate, die eine optimale Stadienbestimmung ermoeglicht. (orig.)(abstract truncated)

  20. Quasistatic field simulations based on finite elements and spectral methods applied to superconducting magnets; Quasistatische Feldsimulationen auf der Basis von Finiten Elementen und Spektralmethoden in der Anwendung auf supraleitende Magnete

    Energy Technology Data Exchange (ETDEWEB)

    Koch, Stephan

    2009-03-30

    This thesis is concerned with the numerical simulation of electromagnetic fields in the quasi-static approximation which is applicable in many practical cases. Main emphasis is put on higher-order finite element methods. Quasi-static applications can be found, e.g., in accelerator physics in terms of the design of magnets required for beam guidance, in power engineering as well as in high-voltage engineering. Especially during the first design and optimization phase of respective devices, numerical models offer a cheap alternative to the often costly assembly of prototypes. However, large differences in the magnitude of the material parameters and the geometric dimensions as well as in the time-scales of the electromagnetic phenomena involved lead to an unacceptably long simulation time or to an inadequately large memory requirement. Under certain circumstances, the simulation itself and, in turn, the desired design improvement becomes even impossible. In the context of this thesis, two strategies aiming at the extension of the range of application for numerical simulations based on the finite element method are pursued. The first strategy consists in parallelizing existing methods such that the computation can be distributed over several computers or cores of a processor. As a consequence, it becomes feasible to simulate a larger range of devices featuring more degrees of freedom in the numerical model than before. This is illustrated for the calculation of the electromagnetic fields, in particular of the eddy-current losses, inside a superconducting dipole magnet developed at the GSI Helmholtzzentrum fuer Schwerionenforschung as a part of the FAIR project. As the second strategy to improve the efficiency of numerical simulations, a hybrid discretization scheme exploiting certain geometrical symmetries is established. Using this method, a significant reduction of the numerical effort in terms of required degrees of freedom for a given accuracy is achieved. The problem-tailored discretization approach is based on a geometrical modeling of reduced spatial dimension inside respective domains of symmetry. For the approximation of the electromagnetic fields, orthogonal polynomials along the direction of symmetry are combined with finite element shape functions at the remaining cross-section. This leads to an efficient method providing a high accuracy. The domains of symmetry are embedded into the surrounding region by means of a strong coupling at the discrete level in terms of a domain decomposition approach. Using this strategy, for certain examples a level of accuracy corresponding to numerical models featuring several millions of degrees of freedom in classical finite element methods can be achieved with only one hundred thousand unknowns. This is demonstrated for different examples, e.g., a cylindrical power transformer and the already mentioned accelerator magnet. (orig.)

  1. 1834 till 2009 - review of 175 years of wire rope development and application in the mining industry; 1834 bis 2009 - Rueckblick auf 175 Jahre Drahtseilentwicklung und Anwendung im Bergbau

    Energy Technology Data Exchange (ETDEWEB)

    Dill, Rainer [Verein fuer Technische Sicherheit und Umweltschutz e.V. (TSU), Gotha (Germany); DMT GmbH und Co. KG, Leipzig (Germany)

    2010-03-15

    Inspector of Mines Albert is the main focus of attention in this contribution. Hence in particular the creative and technically brilliant work since his entry into the Harz mining industry are described in addition to his career. Thanks to his untiring efforts a usable wire rope was introduced into mining industry for the first time in 1834. However, the inventive genius and technical skill of Muehlenpfordt and Mummenthey, employees of the Koenigshuette in Lauterberg, also deserve praise, because they were the first to supply suitable wires for the manufacture of a rope. (orig.)

  2. Application of the inter-line PCR for the analyse of genomic rearrangements in radiation-transformed mammalian cell lines; Anwendung der Inter-Line PCR zur Analyse von genomischen Veraenderungen in strahlentransformierten Saeugerzellinien

    Energy Technology Data Exchange (ETDEWEB)

    Leibhard, S.; Smida, J. [Muenchen Univ. (Germany). Strahlenbiologisches Inst.; Eckardt-Schupp, F.; Hieber, L. [GSF-Inst. fuer Strahlenbiologie, Oberschleissheim (Germany)

    1996-12-31

    Repetitive DNA sequences of the LINE-family (long interspersed elements) that are widely distributed among the mammalian genome can be activated or altered by the exposure to ionizing radiation [1]. By the integration at new sites in the genome alterations in the expression of genes that are involved in cell transformation and/or carcinogenesis may occur [2, 3]. A new technique - the inter-LINE PCR - has been developed in order to detect and analyse such genomic rearrangements in radiation-transformed cell lines. From the sites of transformation- or tumour-specific changes in the genome it might be possible to develop new tumour markers for diagnostic purpose. (orig.) [Deutsch] Repetitive DNA-Sequenzen der LINE-Familie, die weit verbreitet im Genom von Saeugerzellen vorkommen, koennen durch Exposition mit ionisierender Strahlung aktiviert und veraendert werden [1]. Durch eine Neu- bzw. Reintegration an anderen Positionen im Genom kann es zu bedeutenden Veraenderungen im Genom der Zelle kommen. Die Expression von Genen, die bei den Prozessen der Zelltransformation bzw. der Karzinogenese beteiligt sind, kann dadurch veraendert werden [2, 3]. Mithilfe der von uns entwickelten Inter-LINE PCR und der anschliessenden Analyse der veraenderten Produktmuster nach gelelektrophoretischer Auftrennung koennen solche `genomic rearrangements` unter Beteiligung von LINE-Elementen untersucht und naeher charakterisiert werden. Durch Klonierung und Sequenzierung transformations- bzw. tumorspezifischer PCR-Produkte sollte es moeglich sein Tumormarker fuer diagnostische Zwecke zu entwickeln. Die Methode wurde fuer die Analyse von Zellen des Syrischen Hamster aufgebaut, sie ist jedoch universell fuer alle Saeuger anwendbar. (orig.)

  3. Investigations of glass sealing and reactive air brazing materials for joining high temperature solid oxide fuel cells by dilatometric examinations; Anwendung dilatometrischer Messungen bei der Entwicklung von Glasloten und reaktiven Metallloten zum Fuegen von Hochtemperaturbrennstoffzellen

    Energy Technology Data Exchange (ETDEWEB)

    Reichle, M.S. [Parker Hannifin GmbH, Bietigheim-Bissingen (Germany); Federmann, D. [Forschungszentrum Juelich GmbH, ZAT, Juelich (Germany); Reisgen, U. [RWTH Aachen University, ISF, Aachen (Germany); Koppitz, T.

    2011-03-15

    The principle of operation of solid oxide fuel cells (SOFCs) is very simple. However, the fact that very different materials are used for the individual components requires advanced thermal joining techniques to join them in a functional manner. Two very distinct designs have established themselves for the two different intended applications: decentralised power generation (stationary SOFCs) on the one hand, and power converters for vehicles (mobile SOFCs) on the other hand. As a consequence, alternative techniques for joining the individual components are also required. The principal joining process for the stationary SOFC design consists of joining individual steel plates with a glass sealant in an electrically insulating way so that they form an SOFC stack. For the mobile fuel cell design, the SOFC stack consists of individual thin steel cassettes. The window frame of the cassettes, which is made of ferritic chromium steel, is brazed to the ceramic layer of the zirconium oxide solid electrolyte using a filler metal. The material used is a silver-based brazing filler metal which contains only small amounts of copper oxide (CuO) and titanium hydride (TiH{sub 2}) as wetting agents. Both joining processes must be applicable in normal atmospheric air, i. e. under oxidative conditions. R and D activities continue for improving the efficiency and long-term operational stability of the technology to such an extent that SOFCs will become ready for the energy sector market. The two joining techniques described cannot yet be considered standard processes. They, too, will require continuous improvement with respect to reproducibility, endurance and strength of the joints. The Special Joining Techniques working group at Forschungszentrum Juelich uses specially modified dilatometric techniques as suitable quick replacement methods for studying and measuring the joining characteristics of the materials without having to manufacture complex and expensive SOFC stacks. The shrinkage processes in the glass sealant joints are simulated and measured in the {mu}m range using a special dilatometer. In this way, the amount of glass sealant - which is decisive for tightness and bonding - and the process parameters can be determined in advance. With a vertical dilatometer, the melting behaviour of the reactive silver filler metals is examined with respect to melting point shift, viscosity and void ratio, and as a function of the metal additives (Al) and the process atmosphere.

  4. Scaling up manufacturing of ZnO thin layers for application in flexible dye-sensitized solar cells; Aufskalierung der Herstellung von ZnO-Duennschichten fuer die Anwendung in flexiblen farbstoffsensibilisierten Solarzellen

    Energy Technology Data Exchange (ETDEWEB)

    Bittner, Florian

    2012-10-19

    Flexible solar cells possess good future prospects for versatile mobile applications and can provide an important environmental benefit. One of the technologies permitting flexible solar cells is that of dye-sensitized solar cells. Among other advantages the fabrication of these organic-inorganic hybrid solar cells promises to be inexpensive in comparison to other technologies. Nanoparticular TiO{sub 2} is used predominantly as the semiconducting photoanode material; however its preparation route contains a tempering step at about 450 C, which impedes the use of flexible plastic substrates - at least with the method established for dye-sensitized solar cells. An alternative to TiO{sub 2} is ZnO, which can be fabricated for example in an electrochemical process at temperatures of only 70 C in the form of porous quasicrystalline layers. To create porosity the dye eosin Y is used as structure-directing agent. In the context of this study layers prepared by this method were compared to ZnO layers prepared by screen printing. This was performed on glass based substrates. Better conversion efficiency has been determined for dye-sensitized solar cells based on electrochemical deposited layers, while other results indicated advantages for the screen printed layers. As the morphologies of the available screen printed layers proved to be unfavourable and poorly comparable, a concluding statement on the suitability of the different types of layers was eventually not possible. Furthermore a technical simple and inexpensive method for the platinum coating of plastic substrates, which are used as counter electrodes, was tried to be determined. However, layers prepared by technically relatively complex sputtering exhibited by far better properties than layers prepared by electrochemical deposition or by chemical reduction of platinum salts. Thus, the targeted objective has not been reached. The central scope of this study was the development of an electrochemical deposition setup to demonstrate the suitability for scale-up of the fabrication method of ZnO/eosin Y hybrid layers. This miniplant setup was characterised in detail and appropriate deposition parameters have been determined. Porous ZnO layers have been prepared successfully on FTO glass substrates on an area of 38.88 cm{sup 2} and on ITO-PET plastic substrates on an area of 34.56 cm{sup 2}. The suitability of the fabricated layers for the assembly of flexible dye-sensitized solar cells has been demonstrated by means of several operative modules. While these modules achieved decent conversion efficiencies of up to 2.58 % under low light intensities, strongly decreasing conversion efficiencies were observed with increasing light intensities. Too high series resistances have been identified as the cause. (orig.)

  5. Developing and applying a methodology for the scientific classification of publications on carbon capture and storage (CCS); Entwicklung und Anwendung einer Methodik zur wissenschaftlichen Einordnung von Publikationen zum Thema Carbon Capture and Storage (CCS)

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Tobias; Sommer, Karl Christoph; Martens, Per Nicolai [RWTH Aachen (Germany). Inst. fuer Bergbaukunde I

    2012-05-15

    This article describes the conception and application of a methodology to scientifically classify publications on the Carbon Capture and Storage (CCS) topic. The first part of the presented methodology contains an analysis of both the fundamental positioning of the individual stakeholders writing about the CCS topic as well as their individual argumentative focus. For this purpose, all theses, which the individually analyzed stakeholders have included in their publications, are ascertained, classified, weighted, and evaluated. The second part of the methodology contains the linguistic evaluation (terminology) as well as the subsequent comparison of the individual stakeholders' linguistic and content related positions in a graphic depiction. The evaluations indicate that the theses associated with CCS technology in the reviewed publications primarily emphasize the economic and social aspects. The scope of the presented theses varies whereby only the publications of seven of the 28 reviewed stakeholders could be identified as being primarily ''holistically'' oriented. In addition, it can be seen that there is an above average number of stakeholders with a primarily negative position on the CCS topic in publications with a social argumentative focus. Another noticeable relationship exists between an economic argumentation and a positive position on the CCS topic. The linguistic analysis of the publications provides - as was to be expected - a clear correlation of the selected terminology and the argumentative focus. Stakeholders with a primarily negative argumentative focus tend to use therms with a negative connotation. The presented methodology can also be used in similar form in other controversially debated sectors. In principle, it is possible to also transfer this methodology to other topics outside the energy sector. It is, thus, possible to apply this method to any controversially debated topic for which a sufficiently large number of publications exists to help structurize the available literature and to identify the trends in the line of argumentation pursued by the various stakeholders. In addition, the results of the analyses of the diverse stakeholders can also be used as a comprehensive argumentative foundation for reviewing the respective topics as well as for critically examining one's own texts. (orig.)

  6. Alpine solar power station on Sareiserjoch - application of and sturdiness test on a new plastic mounting system; Alpines Solarkraftwerk Sareiserjoch - Anwendung und Haertetest fuer ein neues Kunststoff-Montagesystem

    Energy Technology Data Exchange (ETDEWEB)

    Krause, J. [NEWTEC, Plaston AG, Widnau (Switzerland)

    1997-12-31

    In Malbun in Liechtenstein a grid-connected 22 kW{sub p} PV system has been set up at an altitude of 1900 metres. This system serves its operator as a test of potovoltaics in general and of the mounting systems used in its load-bearing contruction and the fastening of its modules. The present article describes the load-bearing construction and plastic mounting cramp employed. (HW) [Deutsch] Im liechtensteinischen Malbun wurde auf 1900 Metern ueber Meer eine netzgekoppelte 11 kWp-PV-Anlage erstellt, die fuer den Anlagenbetreiber als Test fuer die Photovoltaik im allgemeinen wie auf fuer neue Montagesysteme sowohl bei der Tragkonstruktion als auch bei der Modulbefestigung dienen soll. Tragkonstruktion und Kunststoff-Montageklammer werden dargestellt. (HW)

  7. Two-criteria method for fracture-mechanical analysis of pipelines - practical application and influencing parameters; Zwei-Kriterien-Verfahren zur bruchmechanischen Befundbewertung in Rohrleitungen - praktische Anwendung und Einflussgroessen

    Energy Technology Data Exchange (ETDEWEB)

    Beukelmann, D. [TUeV Sued Industrie Service GmbH (Germany); Doerk, O.; Wernicke, R. [TUeV Nord SysTec GmbH und Co. KG (Germany)

    2006-07-01

    The findings obtained in recurrent inspections as a rule are evaluated by fracture-mechanical analyses. On the basis of the results, it is decided whether a component must be repaired or if operation can continue as it is for the time being. The two-criteria method is applied as a rule because of its universal applicability. Limited ductile crack growth can be taken into account if crack resistance curves are available that can be transferred to the component in question. In the investigations presented here, the influence of the relevant initial variables, e.g. strength coefficents, fracture-mechanical material coefficients, primary and secondary stresses and the intrinsic state of stress is illustrated by exemplary calculations. Further, the safety concepts underlying the assessment are gone into. (orig.)

  8. Development and application of methods and models for the calculation of spatially and temporally highly resolved emissions in Europe; Entwicklung und Anwendung von Methoden und Modellen zur Berechnung von raeumlich und zeitlich hochaufgeloesten Emissionen in Europa

    Energy Technology Data Exchange (ETDEWEB)

    Thiruchittampalam, Balendra

    2014-04-08

    High spatial and temporal resolution models are essential for answering many questions of air quality management and climate modeling. High-resolution emission models are required to determine the concentration of pollutants using chemical transport models, and to quantify the impacts on health and environment and in particular to develop adequate countermeasures. The aim of this work is to develop methods for the calculation of spatially and temporally high-resolved emissions and to apply these exemplarily on a 1 km x 1 km and hourly resolution for the year 2008 in the EU-27 and EFTA countries. The derivation of methods for the spatial and temporal resolution of emissions with corresponding detailed equations is one of the major improvements that have been carried out in the course of this work. The improvement of the spatial distribution of emissions from the point source relevant sectors like energy supply, industry and waste management is achieved by considering sector specific diffuse emission shares. The progress of the spatial distribution of emissions from households is in particular the development of a fuel type weighted distribution over Europe. Another main focus is the development of the spatial distribution of road transport emissions. Due to the restricted access to traffic count data at the European level, methods have been established to provide reliable emissions on grid level for Europe. The progress in the spatial distribution of agricultural emissions is achieved by the consideration of diffuse shares similar to the other point source relevant sectors like energy supply or industry. In addition to the spatial distribution of the emissions the temporal resolution is a main focus of this work, since the state of knowledge of the temporal resolution of emissions in Europe is still rudimentary. Therefore, it was necessary to develop in particular time curves for the hourly resolution of emissions for the main sectors, namely electricity and heat supply, households, commercial, trade and services, road transport and agriculture. One of the main focuses of the development of temporal profiles was specifically to consider temperature data and other parameters. The derivation of the time profiles requires huge amount of indicator data for each time step. Consequently, the goal for the development of temporal profiles in Europe is to derive temperature dependent equations which are capable of generating sector specific profiles for the present as well as for the future. Based on the developed methods, for the first time the visualization of hourly emissions on a 5 km x 5 km for Europe could be shown. The basis for the visualization was the calculation of hourly emissions at a 1 km x 1 km resolution. Due to the lack of quantitative uncertainty assessments, it was necessary to identify the reasons for the lack of uncertainty analysis at the European level and also to describe the possibilities of a quantitative uncertainty analysis for high resolution emission models. Moreover, on the basis of examples it was possible to describe, how the spatial and temporal uncertainty analysis of high resolution emission models can be carried out.

  9. Non-Markovian dynamics, decoherence and entanglement in dissipative quantum systems with applications to quantum information theory of continuous variable systems; Nicht-Markovsche Dynamik, Dekohaerenz und Verschraenkung in dissipativen Quantensystemen mit Anwendung in der Quanteninformationstheorie von Systemen kontinuierlicher Variablen

    Energy Technology Data Exchange (ETDEWEB)

    Hoerhammer, C.

    2007-11-26

    In this thesis, non-Markovian dynamics, decoherence and entanglement in dissipative quantum systems are studied. In particular, applications to quantum information theory of continuous variable systems are considered. The non-Markovian dynamics are described by the Hu-Paz-Zhang master equation of quantum Brownian motion. In this context the focus is on non-Markovian effects on decoherence and separability time scales of various single- mode and two-mode continuous variable states. It is verified that moderate non-Markovian influences slow down the decay of interference fringes and quantum correlations, while strong non-Markovian effects resulting from an out-of-resonance bath can even accelerate the loss of coherence, compared to predictions of Markovian approximations. Qualitatively different scenarios including exponential, Gaussian or algebraic decay of the decoherence function are analyzed. It is shown that partial recurrence of coherence can occur in case of non-Lindblad-type dynamics. The time evolution of quantum correlations of entangled two-mode continuous variable states is examined in single-reservoir and two-reservoir models, representing noisy correlated or uncorrelated non-Markovian quantum channels. For this purpose the model of quantum Brownian motion is extended. Various separability criteria for Gaussian and non-Gaussian continuous variable systems are applied. In both types of reservoir models moderate non-Markovian effects prolong the separability time scales. However, in these models the properties of the stationary state may differ. In the two-reservoir model the initial entanglement is completely lost and both modes are finally uncorrelated. In a common reservoir both modes interact indirectly via the coupling to the same bath variables. Therefore, new quantum correlations may emerge between the two modes. Below a critical bath temperature entanglement is preserved even in the steady state. A separability criterion is derived, which depends on the bath temperature and the response function of the open quantum system. Thus, the extended quantum Brownian motion model of a two-mode continuous variable system in a common reservoir provides an example of quantum noise-induced entanglement. (orig.)

  10. Application of extracellular gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis; Anwendung von extrazellulaeren gadoliniumhaltigen MR-Kontrastmitteln und Risiko der Nephrogenen Systemischen Fibrose

    Energy Technology Data Exchange (ETDEWEB)

    Heverhagen, J.T. [Univ. Hospital Bern (Switzerland). Inst. of Diagnostic, Interventional and Pediatric Radiology, Inselspital; Krombach, G.A. [Justus Liebig Univ. Hopsital Giessen (Germany). Diagnostic and Interventional Radiology; Gizewski, E. [Medical Univ. Innsbruck (Austria). Dept. of Neuroradiology

    2014-07-15

    Nephrogenic systemic fibrosis (NSF) is a serious, sometimes fatal disease. Findings in recent years have shown that a causal association between gadolinium containing contrast media and NSF is most likely. Therefore, the regulatory authorities have issued guidelines on the use of gadolinium-containing contrast media which have reduced the number of new cases of NSF to almost zero. However, it is for precisely this reason that the greatest care must still be taken to ensure that these guidelines are complied with. The most important factors are renal function, the quantity of gadolinium administered and coexisting diseases such as inflammation. All of these factors crucially influence the quantity of gadolinium released from the chelat in the body. This free gadolinium is thought to be the trigger for NSF. Other important factors are the stability of the gadolinium complex and furthermore the route of its elimination from the body. Partial elimination via the liver might be an additional protective mechanism. In conclusion, despite the NSF risk, contrast-enhanced MRI is a safe diagnostic procedure which can be used reliably and safely even in patients with severe renal failure, and does not necessarily have to be replaced by other methods.

  11. Small specimen test results and application of advanced models for fracture mechanics assessment of RPV integrity; Ergebnisse von Kleinproben und Anwendung von Modellansaetzen zur bruchmechanischen Bewertung der RDB-Integritaet

    Energy Technology Data Exchange (ETDEWEB)

    Keim, Elisabeth; Huemmer, Matthias [AREVA NP GmbH (Germany); Hoffmann, Harald [VGB (Germany); Nagel, Gerhard [e-on Kernkraft (Germany); Kuester, Karin [VENE (Germany); Koenig, Guenter; Ilg, Ulf [EnBW (Germany); Widera, Martin [RWE (Germany); Rebsamen, Daniel [KKW Goesgen (Germany)

    2008-07-01

    For the RPV (reactor pressure vessel) integrity assessment the transferability of specimen test results to components is of main importance. The international project TIMES (transferability of fracture toughness of irradiated materials to components and structures) is focussed on the transferability of fracture mechanical characteristics of irradiated materials to components or structures, in order to allow the quantification of differences between sample and component characteristics based on experiments and calculations. The studies were performed for the brittle and brittle-ductile regions of the material characteristics using specimens from original RPV materials in different conditions. Based on case studies the consequence of a component assessment with postulated defects are shown when specimen-related materials properties are used. Since it is not possible to prove the transferability for an RPV in detail, component-similar effects were investigated that allow in combination with numerical modelling to quantify the safety margin. Samples and experimental procedures were developed that simulated the real component situation. The effects of crack depth and multiaxial loads, relevant for real components, were investigated with these samples. A micromechanical model was developed based on the weakest link theory and the statistical failure probability; this model is used for the prediction of fracture toughness of samples and components with defects. For a component with postulated defects the safety margin was assessed using different methodologies, based on standard fracture mechanical samples, taking into account component specific aspects. [German] Fuer die Bewertung der RDB-Integritaet ist die Uebertragbarkeit von Probenkennwerten auf Bauteile von grosser Bedeutung. Dazu wurde das Projekt ''TIMES'' - ein internationales Projekt zur Uebertragbarkeit von Bruchzaehigkeitskennwerten von bestrahlten Materialien auf Komponenten und Strukturen - durchgefuehrt, um anhand von Experimenten und Berechnungen Abstaende zwischen Proben- und Bauteilkennwerten zu quantifizieren und aufzuzeigen, welche Moeglichkeiten fuer die Uebertragbarkeit bestehen. Die Untersuchungen wurden fuer den sproed- und sproedduktilen Uebergangsbereich der Materialkennkurve durchgefuehrt. Sie beinhalten Versuche an original-RDB-Werkstoffen in verschiedenen Zustaenden. Anhand von Fallstudien wird gezeigt, welche Konsequenzen sich fuer eine Bauteilbewertung ergeben, wenn Materialkennwerte ermittelt an Proben fuer die Bewertung von Bauteilen mit postulierten Fehlern verwendet werden. In diesem Projekt wurde als Bauteil der Reaktordruckbehaelter betrachtet. Da es nicht moeglich ist, experimentell die volle Kette der Uebertragbarkeit Probe {yields} RDB nachzuweisen, wurden in TIMES (Transferability of fracture toughness of irradiated materials to components and structures) verschiedene bauteilaehnliche Effekte untersucht, die es erlauben, zusammen mit den numerischen Modellen Sicherheitsabstaende zu quantifizieren. So wurden Proben entwickelt und Experimente durchgefuehrt, die bauteilaehnliche Situationen simulieren, wobei in TIMES spezifisches Augenmerk auf die Verwendung von original bestrahlten RDBWerkstoffen gerichtet wurde. Anhand der Proben wurden Einfluesse wie Risstiefe und mehrachsige Belastung untersucht, die fuer Fehler in Bauteilen relevant sind. Ferner wurden neben diesen Experimenten numerische Verfahren weiterentwickelt, die es erlauben, die Bruchzaehigkeiten der Proben und auch der Bauteile mit Fehlern vorherzusagen. Dazu wurde ein mikromechanisches Modell, basierend auf der weakest link Theorie und der statistischen Versagenswahrscheinlichkeit generiert und fuer die Vorhersagen herangezogen. Fuer ein Bauteil mit postulierten Fehlern wurde mittels verschiedener Methoden der Sicherheitsabstand aufgezeigt, der sich aus der Verwendung von Standard-Bruchmechanikproben und der Beruecksichtigung von bauteilspezifischen Aspekten ergibt. (orig.)

  12. Zur Materialfrage in der Implantatchirurgie des Deszensus: Vergleich zwischen Polypropylenvlies und dermaler porciner azellulärer Kollagenmatrix unter Berücksichtigung der Erfahrungen nach 7 Jahren Anwendung von Implantaten

    Directory of Open Access Journals (Sweden)

    Fischer A

    2004-01-01

    Full Text Available Ziel der Studie: Die Studie beschreibt Verwendung, Effektivität und Nebenwirkungen zwei verschiedener Implantate, die in der Senkungschirurgie verwendet werden und stellen die Ergebnisse in einen Zusammenhang mit den Erfahrungen mit anderen Implantaten seitens der Autoren und in der Literatur. Material und Methode: 180 Patientinnen mit verschiedenen Formen von Genitalprolaps werden mit Biomesh(R behandelt, 185 Patientinnen mit Pelvicol(R in der Zeit von Juli 2000 bis Dezember 2002. Die Ergebnisse werden verglichen. Ergebnisse: Die Verwendung von Implantaten ist häufig erforderlich, vor allen Dingen in Fällen eines stark zerstörten Beckenbodensystems oder bei Rezidiven. Die Verwendung von Netz-Implantaten in der Senkungschirurgie ist sicher, solange eine vernünftige Implantatstruktur zugrunde liegt. Beide in dieser Studie untersuchten Implantate erfüllen dies zufriedenstellend. Rezidiv- und Senkungszustände der benachbarten Kompartimente müssen getrennt ausgewertet werden, um eine Verwechslung zwischen einem schlechten Therapieergebnis (obwohl es eigentlich gut ist und Strukturschwächen in den (noch nicht behandelten Kompartimenten nicht in einem Topf zu werfen. Die Notwendigkeit einer Explantation, das Ausbilden von Abszessen oder die Abstoßungsreaktion wurden nur gesehen, wenn multifilamente mikroporöse Bänder oder entsprechend strukturiertes Nahtmaterial zur gleichen Zeit eingesetzt worden sind, oder wenn Blutergußbildung nicht durch subtile Hämostase während des Eingriffs unterdrückt werden konnte. Schlußfolgerung: Beide Materialien (Biomesh(R und Pelvicol(R liefern in der Verwendung bei implantatunterstützter Deszensus-Chirurgie gute Ergebnisse, gleich, wo sie auch eingesetzt werden. Es gibt keine signifikanten Unterschiede in der Effektivität oder in der Nebenwirkungsrate. Es bedarf nun der größer angelegten multizentrischen Studien, um alloplastisch unterstützte rekonstruktive Beckenbodenchirurgie nicht nur in den französischsprachigen Ländern zu etablieren.

  13. Eine Extraktkombination aus Cranberry, Brunnenkresse und Meerrettich in der Anwendung bei Frauen mit unkompliziertem Harnwegsinfekt // A Complex Preparation of Cranberry, Horseradish and Watercress in the Treatment of Non-Severe Lower Urinary Tract Infect

    Directory of Open Access Journals (Sweden)

    Thiel I

    2016-01-01

    Full Text Available iIntroduction:/i Urinary tract infections (UTIs are among the most common bacterial infections affecting women. Due to the growing problem of antibiotic resistances there is an urgent need for alternative herbal medicinal products for the treatment of non-severe lower UTIs. Vaccinium macrocarpon is effective through various mechanisms of action without inducing resistances in microorganisms. Thus, an observational study (n = 48 was conducted with a preparation of a standardized cranberry extract (67 mg proanthocyanidines combined with glucosinolates containing extracts of Nasturtium officinale and Armoracia rusticana.br iMethods:/i Women (≥ 18 years with an increase in leukocytes in the urine and clinical symptoms typical for UTIs like dysuria, imperative strangury, augmented or new onset of incontinence and suprapubic pain received one of the tablets containing the combined herbal extracts twice daily during the first week and one tablet per day for the following 4 weeks. After 14 days (t1 and after 35 days (t2 taking the tablets a further survey and control check-up with a urine test have been conducted. Patients with persistent clinical symptoms received an antibiotic, for the others the intake of the tablets with the herbal combined extract preparation was continued.briResults:/i 34 patients (70,8 % could abstain from taking antibiotics within the first 14 days (t1 and 32 patients (66,7 % within 35 days (t2. 28 patients (87,5 % were without symptoms at t2. No adverse events were observed.briConclusion:/i This observational study was the first clinical study performed with a combined extract preparation containing Cranberry, Nasturtium and Armoracia, which furthermore supports the concept of using alternative medicine treating non-severe lower UTIs. p bKurzfassung: /biEinleitung:/i Harnwegsinfektionen (HWIs gehören zu den häufigsten bakteriellen Infektionen, die Frauen betreffen. Durch die wachsende Problematik der Antibiotika-Resistenzen besteht für die Behandlung von unkomplizierten unteren Harnwegsinfektionen (Urethritis, Zystitis, Urethrozystitis ein dringender Bedarf an alternativen pflanzlichen Arzneimitteln. Vaccinium macrocarpon, die amerikanische Cranberry, wirkt durch verschiedene Mechanismen, ohne Resistenzen auszulösen. Aus diesem Grund wurde eine Anwendungsbeobachtung (n = 48 mit einer Zubereitung eines standardisierten Cranberry-Extraktes (67 mg Proanthocyanidine, kombiniert mit senfölglykosidischen Extrakten aus Brunnenkresse (Nasturtium officinale und Meerrettich (Armoracia rusticana, durchgeführt.br iPatienten:/i Frauen (≥ 18 Jahre mit einem Leukozytenanstieg im Harn und klinischen Symptomen typisch für Harnwegsinfektionen wie Dysurie, Harndrang, neu auftretende Inkontinenz und Schmerzen über dem Schambein erhielten in der ersten Woche eine Tablette mit der Extraktkombination zweimal täglich und eine Tablette pro Tag für die folgenden 4 Wochen. Nach 14 Tagen (t1 und nach 35 Tagen (t2 wurde eine weitere Erhebung und Kontrolluntersuchung mit einem Urin-Test durchgeführt. Patientinnen mit anhaltenden klinischen Symptomen bekamen ein Antibiotikum verschrieben, bei den anderen wurde die Einnahme der Extrakte aus Cranberry, Brunnenkresse und Meerrettich fortgesetzt.briErgebnisse:/i 34 Patientinnen (70,8 % konnten innerhalb der ersten 14 Tage (t1 auf die Einnahme eines Antibiotikums verzichten und 32 Patientinnen (66,7 % benötigten auch nach 35 Tagen (t2 kein Antibiotikum. 28 Patientinnen (87,5 % waren zum Zeitpunkt (t2 ohne Symptome. Es wurden keine Nebenwirkungen beobachtet.briSchlussfolgerung:/i Diese Anwendungsbeobachtung ist die erste Studie mit einem entsprechenden Kombinationsextrakt (Cranberry, Brunnenkresse, Meerrettich, die darüber hinaus das Konzept des Einsatzes alternativer Therapeutika zur Behandlung von unkomplizierten unteren HWIs unterstützt.

  14. ASMUS - a numerical model for simulations of wind and pollutant dispersion around individual buildings. II. Dispersion modelling and applications; ASMUS - ein numerisches Modell zur Berechnung der Stroemung und der Schadstoffverteilung im Bereich einzelner Gebaeude. II. Schadstoffausbreitung und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Gross, G. [Hannover Univ. (Germany). Inst. fuer Meteorologie und Klimatologie

    1997-06-01

    For pt.I see ibid., vol.3, p.267-74 (1994). The microscale model ASMUS-F was used to study air flow and dispersion in street canyons. The results demonstrate a strong dependence on car-induced turbulence, while the shape of roofs and trees along the street modify the situation only locally. The simulation results in the finding, that concentration in the canyon follows the relation c {proportional_to} u{sup -n} with n {approx} 0.35. Also the evaluation of statistical measures like the mean value are, compared to observations, very reasonable. (orig.)

  15. Fracture-mechanical analysis of metal/ceramic composites for applications in high-temperature fuel cells (SOFC); Bruchmechanische Untersuchung von Metall/Keramik-Verbunsystemen fuer die Anwendung in der Hochtemperaturbrennstoffzelle (SOFC)

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, Bernd Josef

    2008-08-25

    The author investigated the deformation and damage behaviour of soldered ceramic/metal joints in SOFC stacks, using thermochemical methods. Methods for analyzing sandwich systems and for mechanical characterization of joints were adapted and modified in order to provide fundamental understanding of the mechanical properties of soldered joints. [German] In dieser Arbeit wurde das Verformungs- und Schaedigungsverhalten von Keramik/ Metall-Loetverbindungen fuer SOFC-Stacks thermomechanisch untersucht. Verfahren zur Analyse von Schichtsystemen und fuer die mechanische Charakterisierung von Fuegeverbindungen wurden adaptiert und weiterentwickelt, um zu einem grundlegenden Verstaendnis der mechanischen Eigenschaften von Loetverbindungen zu gelangen.

  16. New findings on the application of in-lake technologies for neutralisation of acid mining lakes; Neue Erkenntnisse zur Anwendung von In-Lake-Verfahren fuer die Neutralisation saurer Bergbaufolgeseen

    Energy Technology Data Exchange (ETDEWEB)

    Rabe, W. [eta AG engineering, Spremberg (Germany); Uhlmann, W. [Institut fuer Wasser und Boden Dr. Uhlmann, Dresden (Germany)

    2006-07-01

    The neutralisation of acidic open cast mining lakes is an important task at the restoration of post lignit mining landscapes in Lusatia and Middle Germany. From several treatment technologies for the manipulation of ground and surface waters the in-lake-treatment procedures are most cost effective, licensable and usable with passable risks to reach ecological targets. The proceedings and the results of a two-stage-treatment technology of the Horstteich near Luckau will be exemplified in this article. In this case it was possible, within 20 days, to improve the water quality from extreme acidic (pH {approx} 2.8) to neutral conditions (pH > 8). During the neutralisation nearly all heavy metals and suspended substances were precipitated and a noticeable buffer was built up against acidic inflows. (orig.)

  17. Source oriented modeling of the nitrat pollution of surface waters - application of the immission method for the reporting according to the EC nitrat guideline; Verursacherbezogene Modellierung der Nitratbelastung der Oberflaechengewaesser - Anwendung des Immissionsverfahrens zur Berichterstattung zur EU-Nitratrichtlinie

    Energy Technology Data Exchange (ETDEWEB)

    Behrendt, H.; Opitz, D. [Institut fuer Gewaesseroekologie und Binnenfischerei im Forschungsverbund Berlin e.V. (Germany); Bach, M. [Gesellschaft fuer Boden- und Gewaesserschutz e.V. (Germany); Pagenkopf, W.G. [Geodaten Integration und Analyse, Berlin (Germany)

    2000-09-20

    The observation of 152 monitoring stations of the German countries does not exceed the 50 mg/l target for nitrate. But a good water quality in relation to nitrate can be observed at only 14% of these monitoring stations. If variations in the nitrate concentrations caused by variation of runoff are neglected unique trends of the nitrate pollution from agriculture can not be detected since the mid of 80's. More detailed analysis were carried out for 15 EU monitoring stations. The average winter concentration of nitrate is for the half of these stations constant and a low reduction can be observed for the other half. A similar result shows the average winter concentrations at low flow conditions. The separation of the nitrogen sources into diffuse and point sources using the immission approach shows for both a small decrease for the period 1996-1999 in comparison with the previous period. In contrast to the situation in the mid of 80's the discharges from point sources are decreased and contribute to the total load only in a range of 9-24% in the different river basins. The immission method shows similar results as the emission model. In the mid of the nineties about 67% of the N-inputs into the surface waters of Germany are caused by agricultural activities. The dominant pathway was groundwater with about 48%. The total emissions were reduced by 24% mainly caused by point source reduction. The nitrogen surplus (area related balance) in the agricultural soils were estimated for Germany and for the German countries to show the causes of the nitrogen problem in agriculture. Since 1990 the N-surpluses are reduced and are at present in a range between 70 and 80 kg/ha agricultural area. For the new German countries the N-surplus showed a dramatic decrease in 1990/91 followed by a continuous increase. Contrary the N-surplus in the old German countries is characterised by a slow decrease over the whole time period since 1990. The influence of the order for the application of fertilizer seems to be very low. The comparison of long term changes of nitrogen surplus and nitrate concentration within the river basins allows a raw estimation of the residence times of nitrogen from the topsoil to the river. These times were estimated in a range between about 5 years (Rhine) and more than 20 years (Elbe). (orig.) [German] Die Ueberwachung der Oberflaechengewaesser an den 152 Messstellen der Bundeslaender (LAWA-Messstellennetz) ergab im Berichtszeitraum keine Ueberschreitung des Qualitaetsziels fuer Nitrat von 50 mg/l. Aber bei nur 14% der Messstellen wird eine gute Wasserqualitaet bezueglich Nitrat erreicht. Sieht man von abflussbedingten Schwankungen ab, sind eindeutige Trends der Nitratbelastung aus der Landwirtschaft seit der Mitte der 80er Jahre nicht erkennbar. Vertiefende Analysen wurden fuer die 15 EU-Messstellen Deutschlands durchgefuehrt. Fuer den Trend der mittleren Winterkonzentrationen zeigt sich an jeweils der Haelfte dieser Messstellen Stabilitaet bzw. eine schwache Reduktion. Ein aehnliches Ergebnis ergaben die Winterkonzentrationen bei geringen Abfluessen. Die Separation von diffusen und punktuellen Stickstoffquellen auf Basis des Immissionsverfahrens ergab im Berichtszeitraum 1996-1999 bei beiden Anteilen eine leichte Verminderung gegenueber dem vorangegangenen Vierjahres-Zeitraum. Gegenueber der Mitte der 80er Jahre haben die Punktquellen dagegen z.T. erheblich abgenommen und machen heute nur noch 9-24% in den verschiedenen Flussgebieten aus. Das Immissionverfahren zeigt die gleichen Ergebnisse wie die Emissionsschaetzungen. Mitte der 90er Jahre stammten danach ungefaehr 67% der Stickstoffbelastungen der Oberflaechengewaesser aus landwirtschaftlichen Flaechen. Der Weg ueber das Grundwasser war mit 48% der bedeutendste. Die Gesamtemissionen haben vor allem durch Verringerung der Punktquellen um etwa 24% abgenommen. Zur Darstellung der Urachen in der Landwirtschaft wurden die Stickstoffueberschuesse (Flaechenbilanz) Deutschlands und deren regionale Verteilung in den Bundeslaendern ermittelt. Seit 1990 haben die Ueberschuesse etwas abgenommen und liegen heute zwischen 75 und 80 kg/ha LF. Dabei folgte in den neuen Bundeslaendern einem starker Einbruch 1990/91 ein kontinuierlicher Anstieg, waehrend in den alten Laendern die Bilanzueberschuesse langsam sanken. Die Wirkung der Duenge-Verordnung ist nur sehr gering. Vergleiche zwischen der Entwicklung der Stickstoffueberschuesse und der Nitratkonzentrationen machen erste Schaetzungen ueber die Reaktionszeiten der Flussgebiete auf Aenderungen in der Landwirtschaft moeglich. Diese Zeiten liegen in einem Bereich von etwa 5 Jahren (Rhein) bis zu mehr als 20 Jahren (Elbe). (orig.)

  18. Fabrication and examination of epitaxial HTSC/isolator thin films on sapphire substrates for application in high frequency devices; Herstellung und Untersuchung von epitaktischen HTSL/Isolator-Schichten auf Saphirsubstraten zur Anwendung in HF-Bauelementen

    Energy Technology Data Exchange (ETDEWEB)

    Kittel, H.

    1995-10-01

    The use of high temperature superconductors (HTSC) like YBCO with distinct lower surface resistance compared to normal conductors allows miniaturisation of high frequency (HF) circuits. The object of this work was the fabrication of YBCO thin films on low loss sapphire substrates applicable for stripline devices. To induce epitaxial growth and to avoid chemical reaction at the film-substrate boundary buffer layers were investigated. The examination of the growth properties and especially of the surface impedance has been allotted particular importance. In contrast to CaTiO{sub 3} it was possible to deposit CeO{sub 2}-buffer layers in direct growth up to a thickness of about 30 nm without cracks. The films show all growth properties required and even Laue-oscillations being a feature of high quality growth enabling the determination of film thickness distribution without destruction. The YBCO growth-, transport- and HF-properties meet the ones of YBCO films on standard substrates. A remarkable result is that the mosaic distribution of the CEO film, itself strongly dependend on film thickness, does not influence that of the YBCO film considerably. Rather it changes its shape subsequently due to YBCO deposition. A further particularity in contrast to deposition on standard substrates is the need to adjust the substrate heater tempeature for deposition of YBCO films with thicknesses {>=}300 nm needed for HF application. To demonstrate their usefullness some stripline devices like planar coils and side coupled filters have been fabricated and characterised. (orig.)

  19. Librarian - phase 2. Subproject: the application of reflectometric interference spectroscopy (RIfS) in biological systems. Final report; Librarian - Phase 2. Teilprojekt: Anwendung des Verfahrens der Reflektometrischen Schichtdickenmessung zur Signaldetektion in biologischen Testsystemen und Festphasensynthesen. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Birk, G.; Hadamovsky, S.

    2000-07-01

    Label free methods that do not require fluorescence markers or radioactive isotopes are of interest for high throughput screening applications. Thus, a new assay type for the RIfS technology was developed. These phosphorylation assay experiments were tested for reproducibility and were validated, initially using a single channel machine. The use of surface active materials to reduce or eliminate non specific binding is recommended. The non specific binding of the individual reagents was an important factor for their integration in the RIfS method. The immobilisation of binding reagents was tested using various methods. Since the various combinations are essentially limitless, they could not be explored to their full extent within the confines of this project. The application of the assay into microtitre plate format was not fully completed within the time frame allotted, however, has since been completed by one of the project participants as part of a further cooperation. Theoretically, this method is also suited to the robotics and sample throughput integral to a HTS system A comprehensive evaluation of RIfS technology regarding its entry into high throughput screening, however can only be made with reservation, due to the limited experience with its use in 96 and 384 microtitre plates. (orig.)

  20. Development and prototypical application of analysis methods for complex anion mixtures in waters and heavy metal organyls in sediments; Entwicklung und prototypische Anwendung von Analysenverfahren fuer komplexe Anionengemische in Waessern und Schwermetallorganylen in Sedimenten. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Anders, B.; Knoechel, A.; Potgeter, H.; Staub, S.; Stocker, M.

    2002-07-01

    When it comes to assessing the hazards emanating from heavy pollutants in waters mere elemental analysis provides too little information. Due to the great differences in toxicity and mobility it is important to know more about the exact species in question. This is particularly true of heavy metals that form stable organyls, specifically As, Pb, Sn and Hg, but also of alkylated arsenic acids, which need to be measured in complex anion mixtures. The purpose of the present project was to develop robust, powerful analysis methods and thus overcome the existing deficit in reliable analysis methods for these substances. An important approach in this connection is the use of coupled chromatography and detection systems for separation and analysis. [German] Hinsichtlich der von einer Schwermetallbelastung in Gewaessern ausgehenden Gefahren liefert die reine Elementanalytik nur unzureichende Aussagen. Aufgrund der grossen Unterschiede in Toxiditaet und Mobilitaet ist die Kenntnis der jeweils vorliegenden Spezies bedeutungsvoll. Dies gilt in besonderem Masse fuer die stabile Organyle bildenden Schwermetalle As, Pb, Sn und Hg sowie die alkylierten Arsensaeuren, die es innerhalb komplexer Anionengemische zu bestimmen gilt. Hinsichtlich ihrer sicheren Bestimmung bestehen methodische Defizite, die das vorliegende Projekt durch die Entwicklung robuster, nachweisstarker Analysenverfahren zu beseitigen versucht. Grosse Bedeutung kommt dabei gekoppelten Systemen aus Chromatographie und Detektion als Trenn- und Bestimmungsmethode zu. (orig.)

  1. Investigations of the oxidation-induced service life of chromium steels for high temperature fuel cell application (SOFC); Untersuchungen zur oxidationsbedingten Lebensdauer von Chromstaehlen fuer die Anwendung in der Hochtemperaturbrennstoffzelle (SOFC)

    Energy Technology Data Exchange (ETDEWEB)

    Ertl, S.T.

    2006-08-17

    The increasing energy consumption of future automobiles should be covered by a solid oxide fuel cell (SOFC) used as an additional energy supply (auxiliary power unit). The application of a SOFC with about 5 kW power in cars requires small size, low weight and an economic fabrication. To achieve this goal the interconnector and the metallic anode substrate (depending on an alternative concept of construction) should be manufactured out of thin Crofer22APU, a high chromium ferritic steel. The scale formation mechanisms on Crofer22APU sheets, wires and powder metallurgical produced foils of different thicknesses were investigated in several atmospheres of water vapour/hydrogen at 800 and 900 C, simulating the anode conditions. For scale characterization a number of conventional analysis techniques such as optical metallography, scanning electron microscopy and X-ray diffraction were used in combination with deflection testing in monofacial oxidation and two-stage oxidation studies using {sup 18}O and H{sub 2} {sup 18}O tracer. With these results a theoretical model for the determination of lifetime was developed for Crofer22APU components in simulated anode gas. It was found that the lifetime at a given temperature depends not only on the surface-to-volume ratio, but also on the geometry of the component (e.g. sheet or wire). The critical Cr content required for breakaway oxidation depends on microcrack formation in the surface oxide scale, which occurs on ridges of a sheet during thermal cycling. The development of a metallic interconnector and a metallic anode substrate requires measures to avoid interdiffusion between the alloy and the bordering nickel-YSZ (yttrium stabilized zirconia) cermet of the anode, or depending on the conception of the stack, the bordering nickel-YSZ cermet of the anode functional layer. Therefore the suitability of preoxidation layers after different preoxidation conditions was tested. It was found that the inhibition of the interdiffusion depends not only on the preoxidation conditions, but also on the conditions under which the nickel layer was applied. (orig.)

  2. 2013 annual meeting of the Deutsche Gesellschaft fuer Zerstoerungsfreie Pruefung (DGZfP). NDE in research, development and application; DGZfP-Jahrestagung 2013. Zerstoerungsfreie Materialpruefung. ZfP in Forschung, Entwicklung und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    This CD-ROM proceedings publication contains the papers and posters of the DGZfP annual meeting 2013, at Bremen, Germany, both in full text and as PowerPoint presentations. The following issues were discussed: computerized tomography, thermography; radiographic, ultrasonic, eddy current and microwave testing. 13 papers were recorded as separate entries in the INIS database.

  3. Measurements of vertical displacement of power station buildings using an automatic stationary hydrostatic measuring system; Anwendung des automatisierten stationaeren hydrostatischen Messsystems fuer die Aufnahme der Vertikalverschiebungen an den Objekten der Kern- und Waermekraftwerke

    Energy Technology Data Exchange (ETDEWEB)

    Lechner, J [Forschungsinstitut fuer Geodaesie, Topographie und Kartographie, Zdiby (Czechoslovakia)

    1997-12-31

    The contribution describes hydrostatic stationary measuring systems for measurements of height variations of a turbine unit. The measuring system developed at the research institute and the algorithms for calibration, measurement and evaluation are presented. Measurements were made on a 500 MW turbogenerator unit at different states of operation. (orig.) [Deutsch] Der Beitrag enthaelt eine kurze Uebersicht ueber die hydrostatischen stationaeren Messsysteme fuer das Gebiet der Messung der Hoehenaenderung eines Grossturbinentisches. Es wird das automatische stationaere hydrostatische Messsystem, das im Forschungsinstitut entwickelt wurde, der Algorithmus der Kalibrierung, der Messung und der Auswertung der Messergebnisse vorgestellt. Es wird das Messergebnis der Vertikalverschiebungen der Konstruktion des Turbogenerators mit der Leistung 500 Megawatt bei seinem verschiedenen Betriebszustand angefuehrt. (orig.)

  4. Bestimmung des Bodenreibungsbeiwertes und der Oberflächenreibung eisbedeckter Wasserflächen im Meiningenstrom der Darß-Zingster Boddenkette und Anwendung auf vertikal integrierte hydronumerische Modelle

    OpenAIRE

    Schönfeldt, Hans-Jürgen; Raabe, Armin; Baudler, Henning

    2016-01-01

    In einem hydronumerischen Modell zur Prognose des Strömungs- und Wasserstandsfeldes flacher Gewässer wird eine auf der Turbulenztheorie basierende Tiefenkorrektur für den Bodenreibungsbeiwertwert eingeführt und auf der Basis von Berechnungen für die DarßZingster Boddenkette überprüft. Für einen ausgewählten Meßpunkt der Darß-Zingster Boddenkette wurde der Reibungsbeiwert sowohl am Boden als auch unter einer Eisschicht experimentell bestimmt. Die Auswirkungen einer Tiefenkorrektur des Reibungs...

  5. Paul Ricœurs Suche nach einer Neubegründung der Menschenrechte und der Würde durch die Fähigkeiten und die Anwendung der phronèsis

    Directory of Open Access Journals (Sweden)

    Yvanka B. Raynova

    2016-12-01

    The aim of the following article is to reconstruct Paul Ricoeur's concepts of human rights and human dignity by exploring some little-known texts, and to exemplify how these concepts are connected to a specific philosophical conception of human being, which is grounded in a Dialectics between transcendence and incarnation, freedom and dependence, identity and difference, capability and fallibility (fragility. In doing so, I will argue that Ricœur interprets human dignity, which he has never explicitly defined, through the prism of human capabilities, especially of the capability of being responsible. This interpretation allows him to take a differentiated position in the current bioethical debates on the rights of "potential persons" (Embrio and to illustrate how the Aristotelian phronèsis can be used in (bioethical cases where decisions are difficult to take.

  6. Quality-oriented production of brown-coal coke with due regard to its application in metallurgy and environmental protection; Qualitaetsgerechte Erzeugung von Braunkohlenkoks unter Beruecksichtigung der Anwendung in Metallurgie und Umweltschutz

    Energy Technology Data Exchange (ETDEWEB)

    Achtelik, M.; Erken, M.; Juessen, P.; Knapp, A. [Rheinbraun AG, Koeln (Germany)

    1998-12-31

    In the nineteen seventies the Fortuna Nord refining factory of Rheinbraun AG began to restructure its operations from domestic coal briquetting to the manufacture of industrial products. One of these products, high-temperature brown-coal coke, is produced in two hearth-type furnaces. Coke produced in these plants is mainly used in metallurgy and environmental engineering, in the latter especially for flue gas purification. Rheinbraun has succeeded in introducing a quality management system for brown-coal coke which ensures high quality and security of supply. (orig.) [Deutsch] Im Veredlungsbetrieb Fabrik Fortuna-Nord der Rheinbraun AG begann in den 70er Jahren der Strukturwandel vom Hausbrandbrikett zu Industrieprodukten. Eins dieser Produkte, der Hochtemperatur-Braunkohlenkoks, wird in zwei Herdofenanlagen erzeugt. Die Haupteinsatzbereiche des Herdofenkokses sind die Metallurgie sowie der Umweltschutz und hier insbesondere die Rauchgasreinigung. Um die hohe Produktqualitaet und die Liefersicherheit zu gewaehrleisten, hat Rheinbraun ein Qualitaetsmanagementsystem fuer Braunkohlenkoks erfolgreich eingefuehrt. (orig.)

  7. High-k materials in the electrolyte/insulator/silicon configuration. Characterization and application in bio-electronics; Hoch-k-Materialien in der Elektrolyt/Isolator/Silizium-Konfiguration. Charakterisierung und Anwendung in der Bioelektronik

    Energy Technology Data Exchange (ETDEWEB)

    Wallrapp, F

    2006-12-19

    In order to elicit action potentials in nerve cells adhered on electrodes, a certain current is required across the electrode. Electrochemical reactions may cause damage to cells and electrodes. This is evaded by using silicon electrodes which are insulated by a dielectric. In doing so, only capacitive current is flowing, and electrochemical are avoided. The aim of this work was to fabricate novel stimulation chips exhibiting an enhanced capacitance which render new biological applications possible. These chips were to be characterized and used for the stimulation of cells. The formerly used dielectric SiO{sub 2} was replaced by HfO{sub 2} and TiO{sub 2}, with both of them featuring a higher dielectric constant. They were deposited on the silicon substrate by ALD (atomic layer deposition). The chips were characterized in the electrolyte/insulator/semiconductor (EIS) configuration. Owing to the low leakage current of the EIS configuration, the characterization of the high-k materials was possible in more detail as compared to using a metallic top contact (MIS configuration). The voltage-dependent capacitances of the HfO{sub 2} films could be interpreted by means of a common metal/SiO{sub 2}/silicon system. In contrast, the TiO{sub 2} films exhibited interesting properties which could only be rationalized with the help of numerical calculations assuming free electrons in the TiO{sub 2}. The low-lying conduction band of TiO{sub 2} caused accumulation of electrons within the TiO{sub 2} for certain voltages, which led to an enhanced capacitance. The effects of high voltages, frequency, film thickness and interlayer composition were examined and brought into compliance with the model. The novel TiO{sub 2} stimulation devices featured a five-fold capacitance increase as compared to former SiO{sub 2} chips. Using them, two fundamental stimulation mechanisms were induced in HEK293 cells expressing the recombinant potassium channel Kv1.3: Opening of ion channels and electroporation of the cell membrane. Depending on the stimulus shape, one of these mechanisms or both of them simultaneously could be induced. Because only capacitive current was flowing during stimulation, electrochemical reactions damaging the cell were avoided. The new devices were used successfully also in various other projects, in which they rendered new biological applications possible. (orig.)

  8. Practical application of the microbial activity analysis on the monitoring of the process biological stability of biogas plants; Praktische Anwendung der mikrobiellen Aktivitaetsanalyse zur Ueberwachung der prozessbiologischen Stabilitaet von Biogasanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, Lukas; Tietjen, Carsten [MT-Energie GmbH, Zeven (Germany). Forschung und Entwicklung; Rilling, Norbert [MT-Energie GmbH und Co. KG, Rockstedt (Germany)

    2013-10-01

    As extension for the classical fluorescence microscopic analysis of the microbial population in a biogas fermenter the cell counts and frequency of the different methanogenic organisms was used to generate the plant specific stability indicator called MT-Factor. This factor describes the optimal composition of the microbial population for the current process conditions and could be used for the biological process consulting. A study of the MT-Energie laboratory showed that the combination of the microbial cell counts determination and the plant specific stability factor shifts during a process instability or failure of a biogas fermenter. This analysis of the methane-forming microorganisms as well as their cell count and importance for the entire anaerobic biology of the biogas plant can be used for clearly visualizing and tracking the vitality of the digestion process. The evaluation of the microbial activity of different liquid manure samples could show the influence of inhibitors like disinfectant or cleaning agents directly without time consuming cultivation tests. By determining the MT-Factor and analyzing the activity of the methane formers, an impending influence of inhibitors can be detected in liquid manure before the manure enters the digester. This way, a negative influence on the gas yield can be avoided. (orig.)

  9. The use of a cine-technique in the MRT investigation of the temporo-mandibular joint. Die Anwendung der 'Cine-Technik' in der MRT-Diagnostik des Kiefergelenkes

    Energy Technology Data Exchange (ETDEWEB)

    Vogl, T.J.; Assal, J. (Univ. Muenchen, Radiologische Klinik Innenstadt (Germany)); Eberhard, D.; Weigl, P.; Randzio, J. (Univ. Muenchen, Klinik und Poliklinik fuer Kieferchirurgie (Germany))

    1992-03-01

    A new cine-technique in a prospective study using rapid gradient echo sequences was evaluated for the MRT investigation of the temporo-mandibular joint. A newly developed hydraulic apparatus was used to produce progressive opening of the jaw and MRT appearances were recorded during predetermined points of mandibular movement. The investigation included 16 normals and 34 patients. A modified gradient echo sequence was combined with an optimised surface coil or a special double coil and this provided good spatial resolution of the articular disc and of the muscular and bony structure. Amongst the abnormal findings were luxation of the disc (15 cases), tears in the disc (5 cases), late effects of internal derangements (12 cases) and condylar hypermobility (7 cases). The new cine-technique provides specific images in any chosen position of the mandible depending on the clinical disability of the patient. (orig.).

  10. Water quality and management - the use of models for the estimation of the hazard potential for groundwater by organic pollutants in solid waste; Gewaesserguete und Wasserwirtschaft - Anwendung von Modellen zur Abschaetzung der Grundwassergefaehrdung durch organische Stoffe aus Reststoffen

    Energy Technology Data Exchange (ETDEWEB)

    Klein, M.

    2000-08-31

    In this study the deterministic leaching model PELMO was extended in order to consider two additional transport processes (fast transport via the macro porous flow system without equilibrium conditions with respect to sorption, and transport of pollutants in the soil water bound to humic substances). The extended model was implemented into the stochastic estimation model MCPELMO 2.0. The new development has built in 22 leaching scenarios based on a combination of the German soil regions map (12 soil regions) and 9 representative weather stations. As daily temperature and precipitation data over a period of 30 years were available the influence of climatic fluctuations on the percaloate concentrations could be considered. In parallel to the model development nomograms were calculated based on the algorithms of MCPELMO 2.0 making it possible to estimate concentrations in leachate also graphically. The results of the MCPELMO 2.0 simulations were compared with comprehensive simulations over a period of 1000 years performed with the computer model PELMO. The analysis showed that the screening model MCPELMO 2.0 that was orders of magnitude faster than PELMO was nevertheless able to estimate concentrations close to PELMO for most of the substances. It was additionally concluded that the results of the estimation model behave conservative compared to the comprehensive simulations: MCPELMO is often slightly overestimating pollutant concentrations in the percolate. Only for pollutants having KOC values above 5000 L/kg and DT50 numbers above 2000 days MCPELMO was estimating lower concentrations in the percolate than PELMO. (orig.) [German] In diesem Vorhaben wurde das deterministische Versickerungsmodell PELMO um zwei zusaetzliche Transportprozesse erweitert (schneller Stofftransport ueber das Makroporensystem ohne Einstellung von Sorptionsgleichgewichten, sowie Transport von Stoffen im Bodenwasser gebunden an Huminsaeuren) und das erweiterte Modell in das stochastische Abschaetzmodell MCPELMO 2.0 eingebaut. Im neuentwickelten MCPELMO 2.0 sind insgesamt 22 Versickerungsszenarien definiert, die auf einer Kombination der Bodenregionenkarte der Bundesrepublik Deutschland (12 Bodenregionen) mit 9 repraesentativen Klimastationen basieren, von denen taegliche Temperatur- und Niederschlagsdaten ueber einen Zeitraum von 30 Jahren vorlagen. Parallel zu der Modellentwicklung wurden Nomogramme auf der Basis der Algorithmen von MCPELMO 2.0 erstellt, mit denen die Sickerwasserkonzentrationen ebenfalls grafisch abgeschaetzt werden konnten. Die Ergebnisse des Simulationsprogramms MCPELMO 2.0 wurden mit ausfuehrlichen Simulationen ueber jeweils 1000 Jahre mit dem Computerprogramm PELMO verglichen. Die Analyse zeigte, dass das (im Vergleich mit PELMO) um Groessenordnungen schnellere Screeningmodell MCPELMO 2.0 in der Lage war, sinnvolle Konzentrationen im Sickerwasser fuer die meisten Substanzen abzuschaetzen. Darueber hinaus kann davon ausgegangen werden, dass die Abschaetzung im Vergleich mit einer ausfuehrlichen Simulation konservativ ist, das heisst das MCPELMO 2.0 die Konzentrationen tendenziell ueber- und nicht unterschaetzt. Geringere Konzentrationen als bei den ausfuehrlichen PELMO-Simulationen traten nur bei Substanzen mit KOC-Werten oberhalb von 5000 L/kg bzw. Halbwertszeiten oberhalb von 2000 Tagen auf. (orig.)

  11. New certification process starts. Pt. 2. Application of Building Information Modeling (BIM) for the certification according to DGNB; Zertifizierungsprozess auf ''neuen Beinen''. T. 2. Anwendung von Building Informationen (BIM) zur Zertifizierung nach DGNB

    Energy Technology Data Exchange (ETDEWEB)

    Essig, Bernd [SCHOLZE Consulting GmbH, Leinfelden-Echterdingen (Germany). Geschaeftsbereich Ingenieur-Beratungsleistungen in Facility-, Informations-, Qualitaets-, Nachhaltigkeitsmanagement und Energieberatung; Ernst, Tatjana [SCHOLZE Consulting GmbH, Leinfelden-Echterdingen (Germany)

    2013-04-01

    The overall life cycle plays a significant role in the certification by German Sustainable Building Council (Stuttgart, Federal Republic of Germany). In order that certification becomes much more than only a documentation, comprehensive data are requested already in an early phase of planning. Early investigations of alternatives may have a significant influence on the life cycle of a building. But, from where do the auditors achieve these amounts of data without overcharging the partners involved in the planning process with questions. The Building Information Modelling contributes to the development of the future enhancement of process quality by an innovative information management.

  12. Molekularbiologische Analyse der genetischen Diversität des \\(\\textit {Melitaea athalia}\\) / \\(\\it celadussa\\)-Komplexes (Lepidoptera: Nymphalidae) unter Anwendung der ISSR-PCR auf Art-, Unterart- und Populationsebene

    OpenAIRE

    Achtelik, Gerdo

    2007-01-01

    Mit Hilfe der ISSR-PCR wurde erstmalig eine großräumige Populationsanalyse bei einer Tagfalterart am Beispiel von \\(\\it {Melitaea athalia}\\) vorgenommen. Es konnten fünf verwandte Arten der Nymphalidae - \\(\\it {Melitaea diamina}\\), \\(\\textit {M. cinxia}\\) und \\(\\textit {M. aurelia}\\) sowie \\(\\it {Boloria euphrosyne}\\) und \\(\\textit {Issoria lathonia}\\) - untereinander sowie gegenüber \\(\\textit {M. athalia}\\) differenziert werden. 90 Primer wurden geprüft, 8 Primer amplifizierten allein für \\(...

  13. Development and application of a parallel finite volume method for flow simulation on unstructured grids with local refinement; Entwicklung und Anwendung eines parallelen Finite-Volumen-Verfahrens zur Stroemungssimulation auf unstrukturierten Gittern mit lokaler Verfeinerung

    Energy Technology Data Exchange (ETDEWEB)

    Seidl, V.

    1997-11-01

    A finite vomume method for calculation of steady and unsteady flow on unstructured grids is parallelized by local spatial and time decomposition. In the first case, a parallel variant of the conjugated gradient method with multiple local preconditioning is formulated and analyzed. The method is tested for simple applications (e.g. flow around a cylinder). The second part of the publication describes a direct numerical simulation of turbulent flow around a sphere at a Reynolds number of 5000 (based on flow velocity and sphere diameter). Current and Reynolds-averaged flow fields are discussed. Particular emphasis is placed on coordinate-independent representation of the anisotropy ratios of the Reynolds tensor and dissipation tensor. (orig.) [Deutsch] Ein Finite-Volumen-Verfahren fuer die Berechnung stationaerer und instationaerer Stroemungen auf unstrukturierten Netzen wird durch Gebietszerlegung im Raum und Zeit parallelisiert. Fuer die raeumliche Zerlegung wird eine parallele Variante der konjugierten Gradienten Methode mit mehrfacher, lokaler Vorkonditionierung formuliert und analysiert. Anhand einfacher Anwendungsbeispiele (Zylinderumstroemung, deckelgetriebene Nischenstroemung) wird das entwickelte Gesamtverfahren getestet und seine Effizienz bestimmt. Der zweite Teil der Arbeit beschreibt eine direkte numerische Simulation der turbulenten Kugelumstroemung bei einer Reynolds-Zahl von 5 000 (basierend auf Anstroemgeschwindigkeit und Kugeldurchmesser). In der Ergebnisauswertung werden augenblickliche und Reynolds-gemittelte Stroemungsfelder diskutiert und besonderer Wert auf eine koordinatenunabhaengige Darstellung der Anisotropieverhaeltnisse des Reynolds-Tensors und des Dissipationstensors gelegt. (orig.)

  14. Bipolar plates for polymer electrolyte membrane fuel cells made of thermal and electrical high conductivity thermoplastics. Formulation, production, characterization and application; Bipolarplatten fuer Polymerelektrolytmembran-Brennstoffzellen aus thermisch und elektrisch hochleitfaehigen thermoplastischen Kunststoffen. Rezeptierung, Herstellung, Charakterisierung und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, Ralf Leonhard

    2008-07-01

    The upcoming lack of primary energy sources and the need of reducing the anthropogenic climate change led to increased research activities in the field of Fuel Cells (FC) technology within the last ten years in Europe, the USA and Japan. Especially the automotive industry is highly interested in developing zero emission cars as a replacement of nowadays cars within the next twenty years. Not only for mobile applications the Polymer Electrolyte Membrane Fuel Cell systems (PEM-FC systems) is the focus of research and development. Also stationary (PEM-) FC applications seem to be more and more interesting for a decentralized energy supply, producing electricity and heat (Vaillant FC-Systems, Bosch/Junkers). For this purpose, system miniaturizing and weight reduction (70-90 wt-% of the stack itself is due to bipolar- and endplate) is not that essential as it is for mobile appliance, resulting in earlier commercial market introduction of these systems within the next few years. Not only the weight reduction of the FC-stack itself, but also the cost cutting of its components is vital for the economic success of this technology. The three most expensive components of the stack are the perfluorsulfonated ion conducting Membranen (PEM: Nafion, Ashai, Ashai glass), the noble metal catalyst (Platinum and/or Ruthenium) and the Bipolar Plate (BPP). The moulding processes (injection and/or compression moulding) of polymer materials allow highly integrated, tool reduced mass production of tailored stack components like the BP, the endplate, cell frame and peripheral components. The objective of this thesis is to describe the development of an conductive functionalised material suitable for moulding BPP, to investigate compounding optimisation methods (DOE) and evaluate the best fit parameters, to analyse the rheological behaviour of these highly filled compounds, to discuss suitable polymer related manufacturing processes like hot pressing, injection moulding and profile extrusion to mould BPP at a low cost level and to characterize these with different techniques as well as with different material combinations moulded BPP insitu in a fuel cell testing device either as single-cell setup with an active area of 25 cm{sup 2} or in a three-cell Stack with an active area of 75 cm{sup 2}. (orig.)

  15. Possibilities for using a temperature-controlled pyrolysis method in order to determine the bonding form of mecury in soils and sediments; Moeglichkeiten der Anwendung eines temperaturgesteuerten Pyrolyseverfahrens zur Bestimmung der Bindungsform des Quecksilbers in Boeden und Sedimenten

    Energy Technology Data Exchange (ETDEWEB)

    Biester, H.

    1994-12-31

    The bonding behaviour of mercury in solids was investigated by means of a temperature-controlled pyrolysis method. Starting from the special property of elemental mercury to evaporate already at room temperature, a method was developed which permits to characterize different mercury bonding forms on the basis of Hg evaporation behaviour from solids at continuously increased temperature. The method starts from the assumption that it is possible to thermally reduce compounded mercury and release it in elemental form. The focus of the work was on the study of Hg bonding behaviour in soils and sediments. The soil samples used were from the areas of two mercury deposits, different kyanizing sites, some former mirror factories, and a chlor-alkali electrolysis workshop. The investigated sediments are a collection of mercury-polluted samples from the rivers Elbe, Rhine, Murg, the Rio Sao Joao de Meriti (Brazil) and some brooks and rivers of the Saar-Nahe depression. (orig./EF) [Deutsch] In der vorliegenden Arbeit wurde das Bindungsverhalten von Quecksilber in Feststoffen mittels eines temperaturgesteuerten Pyrolyseverfahrens untersucht. Ausgehend von der besonderen Eigenschaften des elementaren Quecksilbers, bereits bei Zimmertemperatur zu verdampfen, wurde ein Verfahren entwickelt, das eine Charakterisierung verschiedener Quecksilberbindungsformen aufgrund des Abdampfverhaltens des Hg aus dem Feststoff unter kontinuierlicher Temperaturerhoehung zulaesst. Dem Verfahren liegt dabei die Annahme zugrunde, dass sich das Quecksilber in seinen Verbindungen thermisch reduzieren und in elementarer Form freisetzen laesst. Durch den kontinuierlichen Aufheizprozess erfolgt die Freisetzung des Quecksilbers in Abhaengigkeit von der Bindungsstaerke in unterschiedlichen Temperaturbereichen. Die Darstellung der Ergebnisse erfolgte in Form von Abdampfkurven, die die Extinktion in Abhaengigkeit von der Temperatur darstellen. Der Schwerpunkt dieser Arbeit lag auf der Untersuchung des Bindungsverhaltens des Quecksilbers in Boeden und Sedimenten. Die untersuchten Bodenproben stammen aus den Bereichen zweier Quecksilberlagerstaetten, verschiedener Kyanisierplaetze, einiger ehemaliger Spiegelfabriken und aus dem Bereich einer Chlor-Alkali-Elektrolyse. Die untersuchten Sedimente stellen eine Auswahl quecksilberbelasteter Proben aus Elbe, Rhein, Murg, dem Rio Sao Joao de Meriti (Brasilien) und einigen Baechen und Fluessen der Saar-Nahe-Senke dar. (orig./EF)

  16. Ribosomal studies on the 70S ribosome of E.coli by means of neutron scattering; Strukturuntersuchungen am 70S-Ribosom von E.coli unter Anwendung von Neutronenstreuung

    Energy Technology Data Exchange (ETDEWEB)

    Burkhardt, N. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Werkstofforschung

    1997-12-31

    Ribosomes are ribonucleo-protein complexes, which catalyse proteinbiosynthesis in all living organisms. Currently, most of the structural models of the prokaryotic 70S ribosome rely on electron microscopy and describe mainly the outer shape of the particle. Neutron scattering can provide information on the internal structure of the ribosome. Parts of the structure can be contrasted for neutrons by means of an isotopic exchange of the naturally occurring hydrogen ({sup 1}H) for deuterium ({sup 2}H), allowing direct measurements in situ. Specifically deuterium-labeled ribosomes (E. coli) were prepared and analysed with neutron scattering. The biochemical methods were established and combined to a generally applicable preparation system. This allows labeling of all ribosomal components in any combination. A systematic analysis of the protein and RNA phases resulted in the development of a new model for the 70S ribosome. This model describes not only the outer shape of the particle, but displays also an experimentally determined internal protein-RNA distribution and the border of subunits for the first time (four-phase model; resolution: 50A). Models of the 70S ribosome from other studies were evaluated and ranked according to consistency with the measured scattering data. Applying a new neutron scattering technique of particular sensitivity, the proton-spin contrast-variation, single proteins could be measured and localized. The positions of the proteins S6 and S10 were determined, providing the first coordinates of protein mass centers within the 70S ribosome. (orig.) [Deutsch] Ribosomen sind Ribonukleinsaeure-Protein Komplexe, die in allen lebenden Organismen die Proteinbiosynthese katalysieren. Strukturmodelle fuer das prokaryontische 70S-Ribosom beruhen derzeit vorwiegend auf elektronenmikroskopischen Untersuchungen und beschreiben im wesentlichen die aeussere Oberflaeche des Partikels. Informationen ueber die innere Struktur des Ribosoms koennen Messungen mit Neutronenstreuung liefern. Durch den Austausch des natuerlichen Wasserstoffs ({sup 1}H) gegen Deuterium ({sup 2}H) lassen sich Teilstrukturen des Komplexes fuer Neutronen kontrastieren und direkt in situ vermessen. Im Rahmen der vorliegenden Arbeit wurden solche deuterium-markierten Ribosomenpraeparate (E. coli) hergestellt und mit Neutronen analysiert. Die erforderlichen biochemischen Methoden wurden etabliert und zu einem allgemein anwendbaren Praeparationssystem zusammengefasst. Es koennen damit alle Komponenten des 70S-Ribosoms in beliebiger Kombination markiert werden. Auf der Grundlage einer systematischen Analyse der Protein- und RNA-Phasen konnte ein neues 70S-Ribosomenmodell entwickelt werden, das nicht nur die aeussere Form des Partikels beschreibt, sondern erstmals auch eine vermessene interne Protein-RNA-Verteilung und den Verlauf der Untereinheitengrenze angibt (Vierphasen-Modell; Aufloesung: 50 A). 70S-Ribosomenmodelle aus anderen Studien wurden anhand der gemessenen Streudaten beurteilt und gewichtet. Mit Hilfe einer neuen, besonders empfindlichen Neutronenstreutechnik, der Protonenspin-Kontrastvariation, gelang es ausserdem, einzelne markierte Proteine zu vermessen und zu lokalisieren. Mit den Positionen von S6 und S10 werden die ersten im 70S-Ribosom vermessenen Proteinschwerpunktskoordinaten vorgelegt. (orig.)

  17. Organic semiconductors. Fundamental aspects of metal contacts, highly ordered films and the application in field effect transistors; Organische Halbleiter. Fundamentale Aspekte von Metallkontakten, hochgeordneten Schichten und deren Anwendung in Feldeffekttransistoren

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, Soenke

    2010-05-31

    In this thesis, fundamental aspects of organic semiconductor devices are investigated and incorporated into the construction and optimization of an organic semiconductor field effect transistor (OFET). In order to approach the ''high end'' of OFETs, elaborate steps to optimize the devices are taken, despite the fact that they might not be feasible in a direct application. Well-characterized model systems are selected to study fundamental properties of devices, in particular the electronic structure at molecule/metal contacts and in the organic semiconductor bulk, as well as the growth of organic semiconductor molecules on single crystalline insulator substrates. The realization of a high performance OFET is pursued by a comprehensive approach in order to optimize particularly the interfaces of the device. Considerable progress is made towards a working OFET with best possible properties. A primary focus of this work, the investigation of the electronic structure at molecule/metal contacts and in the molecular bulk of the model system PTCDA/Ag(111) is performed using two photon photoelectron spectroscopy (2PPE). Of special interest is the excitation of the lowest unoccupied molecular orbital (LUMO) that shows different energetic relaxation mechanisms, depending on the origin of excitation. In addition to the importance of the molecule/metal contacts, the performance of OFETs is determined to a large extend by the quality of the organic semiconductor/gate insulator interface where the charge carrier channel is established. The morphology and structure of a molecular layer are investigated for diindenoperylene (DIP) molecules, adsorbed on a single crystalline Al{sub 2}O{sub 3} substrate, by atomic force microscopy and optical microscopy. Dependent on the substrate temperature during growth, the morphology shows grains with lateral dimensions of about 200 nm at 350 K which increase up to 700 nm at 450 K. This change in morphology is accompanied by an increase of roughness, indicating a change of the growth mode, at higher temperatures. At slightly higher temperatures of about 460 K, the growth of crystallites is observed. Depending on the particular preparation parameters, three different types of crystallites develop: mesa crystallites with lateral dimensions up to several microns, dendritic crystallites, characterized by kinetic growth processes, and layered crystallites, that are bent in three dimensions. Possibilities to utilize the grown crystallites in OFETs are discussed and the mesa type is found to be the most promising. The comprehensive concept for the development of a high performance OFET is introduced and refined in details. Improvements are made especially in the construction of the gate electrode that will be attached beneath the Al{sub 2}O{sub 3} substrate. To thin out the substrate, a drilling technique is improved and combined with wet chemical etching, resulting in gate insulator thicknesses below 10 {mu}m. On the basis of this preparatory work few first OFETs were built. As a first step towards the electrical characterization of DIP-OFETs, OFETs based on Silicon-oxide were successfully prepared and characterized. Moreover, present challenges and possible improvements towards a high performance OFET are discussed. (orig.)

  18. Development of a regional concept for energy management for the region of Karlsruhe. Final report; Entwicklung eines regionalen Energiemanagement-Konzeptes und Anwendung auf die TechnologieRegion Karlsruhe. Endbericht

    Energy Technology Data Exchange (ETDEWEB)

    Rentz, O.; Fichtner, W.; Frank, M. [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Industriebetriebslehre und Industrielle Produktion; Wolf, M.A.; Rejman, M.; Eyerer, P. [Fraunhofer-Institut fuer Chemische Technologie (ICT) (Germany); Reimert, R.; Schulz, A.; Buren, V. v. [Karlsruhe Univ. (T.H.) (Germany). Engler-Bunte-Institut Bereich 1 - Gas, Erdoel und Kohle; Schaefers, B.; Bernart, Y. [Karlsruhe Univ. (T.H.) (DE). Institut fuer Soziologie (IfSoz) (Germany)

    2002-09-01

    Major objectives of this project are: to prepare a cross-disciplinary analysis of all characteristic aspects of the energy supply and demand patterns of a group of selected energy-intensive companies in the Karlsruhe and Rhine harbour area (5 industrial power consumers, 1 utility), to identify practical approaches for optimization and integration of energy and material flows, (networking), and to develop optimised investment and energy supply options within the framework of given conditions. The basis of the optimal solution and energy network presented and explained in detail is a new combined-cycle power plant running as a gas-fired CHP plant, substituting about 50% of the systems formerly used. (orig./CB) [German] Fragestellungen der Effizienzsteigerung und der Verwertung von Abfaellen und Abwaerme gewinnen an Relevanz vor dem Hintergrund der begrenzten Aufnahmekapazitaet der Umweltmedien fuer Schadstoffe. Im Rahmen des Projektes wurde am Beispiel der Region Karlsruhe (5 Industrieunternehmen und 1 EVU) die Entwicklung betriebsuebergreifender Energieversorgungssysteme (Netzwerke) interdisziplinaer analysiert und beschrieben. Zielsetzungen des Projekts waren unter anderem: Bestimmung von zukunftsfaehigen Optionen, intelligente Vernetzung von Energiestroemen, wirtschaftliche Optimierung betriebsuebergreifender Energiemanagement-Loesungen. Die optimale vorgestellte Loesung ist charakterisiert durch den Neubau einer zentralen, gasgefeuerten GuD-Anlage, die etwa die Haelfte der bisherigen Anlagen ersetzt und zusammen mit den weiterhin genutzten Anlagen die Energieversorgung der Unternehmen sicherstellt. (orig./CB)

  19. Planning, installation and use of ventilation systems for smoke and heat removal. Cooperation between architects, planners, and builder-owners; Planung, Einbau und Anwendung von Rauch- und Waermeabzugsanlagen. Zusammenwirken zwischen Architekt, Planer und Bauherr

    Energy Technology Data Exchange (ETDEWEB)

    Koschnitzki, K. [Duisburg Univ. (Germany). Inst. fuer Anlagenplanung und Systemtechnik; Berg, M. [e.t.s. Umwelt- und Sicherheitstechnik GmbH, Kleve (Germany)

    1998-05-01

    Cooperation between planners, builder-owners and technical experts is important for efficient fire prevention. This involves ventilation systems for smoke and heat removal as well as other safety components. Legal regulations must be implemented so as to obtain a fire protection concept with defined goals and to achieve maximum protection of furniture and inhabitants. (orig.) [Deutsch] Bei der Umsetzung von Brandschutzkonzepten in der Gebaeude- und Anlagenplanung ist das gemeinsame Vorgehen von Planer, Bauherr und Fachunternehmen von elementarer Wichtigkeit fuer ein ausgereiftes Sicherheitskonzept. Hierzu gehoeren Rauch- und Waermeabzugsanlagen und weitergehende sicherheitstechnische Komponenten. Auflagen und behoerdliche Bestimmungen sind so umzusetzen, dass ein Brandschutzkonzept mit definierten Schutzzielen entsteht. Fuer den Bauherrn soll ein maximaler Sachwert- und Personenschutz gewaehrleistet sein. (orig.)

  20. Development, validation and application of a process for the generation of long-term stable VOC gas mixtures; Entwicklung, Validierung und Anwendung eines Verfahrens zur Erzeugung langzeitstabiler VOC-Gasgemische

    Energy Technology Data Exchange (ETDEWEB)

    Richter, Matthias

    2010-07-01

    The development as well as the validation of a gas mixing system (GMS) that enables dynamic and traceable production of stable long-term VOC gas mixtures within the range between a few {mu}g/m{sup 3} and a few 100 {mu}g/m{sup 3}, is discussed. In this method pure liquid substances that are filled into stainless steel bottles are kept separately at a constant temperature, evaporated according to their vapour pressure and removed by a small inert gas flow. They are finally united in a gas mixing chamber. The carrier gas must be as small as possible so that the quasi-equilibrium between the gas space and the liquid phase in the substance bottles will not be disturbed. The carrier gas is assumed to be saturated with substance gas due to a long residence time in the bottles and a fast phase transition. Any concentration level of the gas mixture can be generated by a combination of vaporization temperature, carrier and dilution gas flows. With the GMS a mixture of 25 VOCs was prepared. For 16 compounds stable and reproducible gas concentrations were realized. Due to not completely removed leakage of some substance bottles and the tubing respectively, variation of the concentration of the remaining compounds was found. A sink effect as another reason for this variation could be expelled and the chemical stability of the vaporized substances proved with the exception of some aldehydes. The procedure was successfully applied in a round robin test and a material test. In the latter adsorption of VOCs on building products was scrutinized. In this way the applicability of the GMS could be shown. (orig.)

  1. Chitosan pads vs. manual compression to control bleeding sites after transbrachial arterial catheterization in a randomized trial; Randomisierte Untersuchung zur Anwendung eines Chitosan-Gerinnungspads zur Blutstillung bei transbrachialen Angiographien

    Energy Technology Data Exchange (ETDEWEB)

    Poretti, F.; Rosen, T.; Koerner, B.; Vorwerk, D. [Inst. fuer diagnostische und interventionelle Radiologie, Klinikum Ingolstadt (Germany)

    2005-09-01

    Purpose: until now, no mechanical closure devices were available to achieve fast and secure hemostasis for vessel closure after catheterization of small arterial vessels. Material and methods: eighty patients were randomized to evaluate the effect on hemostasis by use of a chitosan pad (Chito-Seal, Abbott Vascular Devices, Galway/Ireland) in comparison to manual compression after diagnostic transbrachial arterial catheterization. Hemostasis after three minutes and one hour as well as local development of a hematoma after one and twenty-four hours were assessed. Results: the use of chitosan pads significantly decreased the bleeding time in the first three minutes after manual compression time (p < 0.01). Significant decrease in bleeding risk at three minutes by use of the chitosan closure pads was also found in subgroups of patients with hypertension (p < 0.001) or diabetes (p < 0.01) and also in patients under anticoagulation therapy (p < 0.01). In addition, long-term protection from bleeding complications such as the risk of hematoma was decreased by the use of chitosan closure pads one hour (p < 0.01) or twenty-four hours (p < 0.001) after catheter removal. Conclusion: the use of an intravascular anchor or suture system is not safely applicable in these vessels due to the small diameter of the brachial artery. Our results document a significant improvement in hemostasis by using chitosan pads in these cases. (orig.)

  2. Temperature dependent electronic structure and magnetism of metallic systems with localized moments. Application on gadolinium; Temperaturabhaengige elektronische Struktur und Magnetismus von metallischen Systemen mit lokalisierten Momenten. Anwendung auf Gadolinium

    Energy Technology Data Exchange (ETDEWEB)

    Santos, C.A.M. dos

    2005-06-24

    This thesis focuses on the theoretical investigation of the temperature dependent electronic and magnetic properties of metallic 4f-systems with localized magnetic moments. The presented theory is based on the Kondo-lattice model, which describes the interaction between a system of 4f-localized magnetic moments and the itinerant conduction band electrons. This interaction is responsible for a remarkable temperature dependence of the electronic structure mainly induced by the subsystem of 4f-localized moments. The many-body problem provoked by the Kondo-lattice model is solved by using a moment conserving Green function technique, which takes care of several special limiting cases. This method reproduces the T=0-exact solvable limiting case of the ferromagnetically saturated semiconductor. The temperature dependent magnetic properties of the 4f-localized subsystem are evaluated by means of a modified Rudermann-Kittel-Kasuya-Yosida (RKKY) type procedure, which together with the solution of the electronic part allows for a self-consistent calculation of all the electronic and magnetic properties of the model. Results of model calculations allow to deduce the conditions for ferromagnetism in dependence of the electron density n, exchange coupling J and temperature T. The self-consistently calculated Curie temperature T{sub C} is presented and discussed in dependence of relevant parameters (J, n, and W) of the model. The second part of the thesis is concerned with the investigation of the temperature dependence of the electronic and magnetic properties of the rare-earth metal Gadolinium (Gd). The original Kondo-lattice model is extended to a multi-band Kondo-lattice model and combined with an ab-initio band structure calculation to take into account for the multi-bands in real systems. The single-particle energies of the model are taken from an augmented spherical wave (ASW) band structure calculation. The proposed method avoids the double counting of relevant interactions by exploiting the T=0-exact limiting case of the ferromagnetically saturated semiconductor and takes into account the correct symmetry of the atomic orbitals. The only parameter of the theory (inter-band exchange coupling J) is uniquely fixed by the band structure calculation. The self-consistently derived Curie temperature of 294.1 K and the T=0-magnetic moment of 7.71 {mu}{sub B} are surprisingly close to the experimental values. The induced temperature-dependence of the 5d conduction bands explains respective experimental photoemission data. (orig.)

  3. Methods of analysis in terms of effects and their application to toxic organic constituents of industrial waste water; Methoden und Anwendung der wirkungsbezogenen Analytik auf toxische organische Inhaltsstoffe in industriellen Abwaessern

    Energy Technology Data Exchange (ETDEWEB)

    Reemtsma, T.; Putschew, A.; Jekel, M. [Technische Univ. Berlin (Germany). Fachgebiet Wasserreinhaltung

    1999-07-01

    Coupling biological action detection with chemical sewage analysis opens up a broad spectrum of methods involving diverse amounts of effort, whose results can range from hints to ways of eliminating a toxic effect to the identification and quantification of individual toxic constituents even in complex waste water. These methods help recognizing problems with effluent quality and enhancing treatment concepts. As possible biological effects of sewage discharges into receiving bodies of water (including sublethal effects) are meeting with increasing attention, the importance of sewage analysis in terms of effects will acquire even greater weight. Automated and miniaturized processes can cut down the involved effort substantially in the future. (orig.) [German] Die Kopplung der biologischen Wirkungsdetektion mit chemischer Abwasseranalytik eroeffnet ein breites Spektrum unterschiedlich aufwendiger Methoden, deren Ergebnisse von Hinweisen auf Methoden zur Entfernung einer toxischen Wirkung bis zur Identifizierung und Quantifizierung einzelner toxischer Inhaltsstoffe auch in komplexer Abwaessern reichten koennen. Diese Methoden helfen beim Erkennen von Problemen in der Ablaufqualitaet und unterstuetzen bei der Verbesserung von Behandlungskonzepten. Mit steigender Beachtung moeglicher biologischer Wirkungen von Abwassereinleitungen im Vorfluter (unter Einbeziehung sublethaler Effekte) wird die Bedeutung der wirkungsbezogenen Abwasseranalytik noch zunehmen. Automatisierte und miniaturisierte Verfahren koennen zukuenftig den dabei zu treibenden Aufwand wesentlich vermindern. (orig.)

  4. Ribosomal studies on the 70S ribosome of E.coli by means of neutron scattering; Strukturuntersuchungen am 70S-Ribosom von E.coli unter Anwendung von Neutronenstreuung

    Energy Technology Data Exchange (ETDEWEB)

    Burkhardt, N [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Inst. fuer Werkstofforschung

    1998-12-31

    Ribosomes are ribonucleo-protein complexes, which catalyse proteinbiosynthesis in all living organisms. Currently, most of the structural models of the prokaryotic 70S ribosome rely on electron microscopy and describe mainly the outer shape of the particle. Neutron scattering can provide information on the internal structure of the ribosome. Parts of the structure can be contrasted for neutrons by means of an isotopic exchange of the naturally occurring hydrogen ({sup 1}H) for deuterium ({sup 2}H), allowing direct measurements in situ. Specifically deuterium-labeled ribosomes (E. coli) were prepared and analysed with neutron scattering. The biochemical methods were established and combined to a generally applicable preparation system. This allows labeling of all ribosomal components in any combination. A systematic analysis of the protein and RNA phases resulted in the development of a new model for the 70S ribosome. This model describes not only the outer shape of the particle, but displays also an experimentally determined internal protein-RNA distribution and the border of subunits for the first time (four-phase model; resolution: 50A). Models of the 70S ribosome from other studies were evaluated and ranked according to consistency with the measured scattering data. Applying a new neutron scattering technique of particular sensitivity, the proton-spin contrast-variation, single proteins could be measured and localized. The positions of the proteins S6 and S10 were determined, providing the first coordinates of protein mass centers within the 70S ribosome. (orig.) [Deutsch] Ribosomen sind Ribonukleinsaeure-Protein Komplexe, die in allen lebenden Organismen die Proteinbiosynthese katalysieren. Strukturmodelle fuer das prokaryontische 70S-Ribosom beruhen derzeit vorwiegend auf elektronenmikroskopischen Untersuchungen und beschreiben im wesentlichen die aeussere Oberflaeche des Partikels. Informationen ueber die innere Struktur des Ribosoms koennen Messungen mit Neutronenstreuung liefern. Durch den Austausch des natuerlichen Wasserstoffs ({sup 1}H) gegen Deuterium ({sup 2}H) lassen sich Teilstrukturen des Komplexes fuer Neutronen kontrastieren und direkt in situ vermessen. Im Rahmen der vorliegenden Arbeit wurden solche deuterium-markierten Ribosomenpraeparate (E. coli) hergestellt und mit Neutronen analysiert. Die erforderlichen biochemischen Methoden wurden etabliert und zu einem allgemein anwendbaren Praeparationssystem zusammengefasst. Es koennen damit alle Komponenten des 70S-Ribosoms in beliebiger Kombination markiert werden. Auf der Grundlage einer systematischen Analyse der Protein- und RNA-Phasen konnte ein neues 70S-Ribosomenmodell entwickelt werden, das nicht nur die aeussere Form des Partikels beschreibt, sondern erstmals auch eine vermessene interne Protein-RNA-Verteilung und den Verlauf der Untereinheitengrenze angibt (Vierphasen-Modell; Aufloesung: 50 A). 70S-Ribosomenmodelle aus anderen Studien wurden anhand der gemessenen Streudaten beurteilt und gewichtet. Mit Hilfe einer neuen, besonders empfindlichen Neutronenstreutechnik, der Protonenspin-Kontrastvariation, gelang es ausserdem, einzelne markierte Proteine zu vermessen und zu lokalisieren. Mit den Positionen von S6 und S10 werden die ersten im 70S-Ribosom vermessenen Proteinschwerpunktskoordinaten vorgelegt. (orig.)

  5. Application and further development of models for the final repository safety analyses on the clearance of radioactive materials for disposal. Final report; Anwendung und Weiterentwicklung von Modellen fuer Endlagersicherheitsanalysen auf die Freigabe radioaktiver Stoffe zur Deponierung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Artmann, Andreas; Larue, Juergen; Seher, Holger; Weiss, Dietmar

    2014-08-15

    The project of application and further development of models for the final repository safety analyses on the clearance of radioactive materials for disposal is aimed to study the long-term safety using repository-specific simulation programs with respect to radiation exposure for different scenarios. It was supposed to investigate whether the 10 micro Sv criterion can be guaranteed under consideration of human intrusion scenarios. The report covers the following issues: selection and identification of models and codes and the definition of boundary conditions; applicability of conventional repository models for long-term safety analyses; modeling results for the pollutant release and transport and calculation of radiation exposure; determination of the radiation exposure.

  6. Measurements of vertical displacement of power station buildings using an automatic stationary hydrostatic measuring system; Anwendung des automatisierten stationaeren hydrostatischen Messsystems fuer die Aufnahme der Vertikalverschiebungen an den Objekten der Kern- und Waermekraftwerke

    Energy Technology Data Exchange (ETDEWEB)

    Lechner, J. [Forschungsinstitut fuer Geodaesie, Topographie und Kartographie, Zdiby (Czechoslovakia)

    1996-12-31

    The contribution describes hydrostatic stationary measuring systems for measurements of height variations of a turbine unit. The measuring system developed at the research institute and the algorithms for calibration, measurement and evaluation are presented. Measurements were made on a 500 MW turbogenerator unit at different states of operation. (orig.) [Deutsch] Der Beitrag enthaelt eine kurze Uebersicht ueber die hydrostatischen stationaeren Messsysteme fuer das Gebiet der Messung der Hoehenaenderung eines Grossturbinentisches. Es wird das automatische stationaere hydrostatische Messsystem, das im Forschungsinstitut entwickelt wurde, der Algorithmus der Kalibrierung, der Messung und der Auswertung der Messergebnisse vorgestellt. Es wird das Messergebnis der Vertikalverschiebungen der Konstruktion des Turbogenerators mit der Leistung 500 Megawatt bei seinem verschiedenen Betriebszustand angefuehrt. (orig.)

  7. Further development of the radioimmunoassay for carcinoembryonic antigen and the use of the measurement of the carcinoembryonic antigen in stools. Weiterentwicklung des Radioimmunoassay fuer carcino-embryonales Antigen und Anwendung auf die Messung von carcino-embryonalem Antigen im Stuhl

    Energy Technology Data Exchange (ETDEWEB)

    Britsch, R F

    1982-01-01

    A specific, direct CEA-RTA is presented with sequential saturation and double antibody separation and using guinea pig CEA anti-serums, whose isolated CEA was marked with /sup 125/I for tracer production and used as was for a CEA standard. This RIA was tested on serum from patients with colorectal and stomach-esophagus carcinomas and from healthy persons, whereby it showed a good sensitivity in comparison to control serums on the market. CEA is also present in a high concentration in the stools, however very nonhomogeneously distributed, by patients as well as healthy persons. An increased stool CEA value does not necessarily indicate a carcinomatic disease or even a preliminary stage. During a screening a carcinomatic intestinal disorder should not be looked for intensively unless there are first several positive stool CEA values or additional positive blood evidence in the stool. Simultaneously carried out determinations of serum and stool CEA allows for the discovery of more patients as the use of only one. (TRV)

  8. The criminal law as an instrument under environmental law in the Netherlands. A survey of the basic legal principles and instruments and their application. Das niederlaendische Umweltstrafrecht. Eine Untersuchung zu den dogmatischen Grundlagen und zur praktischen Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Waling, C.

    1991-01-01

    This book is published in the German language in order to give non-Dutch speaking readers access to and insight into the criminal law applicable in the Netherlands for enforcement of the environmental law. This very comprehensive study discusses the substantive criminal environmental law, its enforcement in practice, and the international criminal law of the Netherlands. Emphasis is placed on the critical evaluation and comparison of the law and day-to-day practice, with this part of the study including a comparison with the situation in the Federal Republic of Germany. The authoress presents recommendations for improving the efficiency of the criminal law system available in the Netherlands for environmental matters. (orig./HP).

  9. The ``Grey System`` theory and its application to target cost forecasting at Chinese collieries; Die Theorie des grauen Systems und ihre Anwendung bei der Prognose der Zielkosten des gesamten Bergwerks

    Energy Technology Data Exchange (ETDEWEB)

    Ding Rijia; Yi Maosheng; Wang Shiyuan

    1997-09-01

    A production-cost forecasting system has been developed for use at Chinese collieries. Known as the `Grey System`, the theory and model-based process distinguishes between `white` information, which is human controlled, `black` information, which cannot be controlled by human actions, and `grey information`, which forms the majority component and comprises information which can only be partly or not completely collected. A grey system is therefore one in which the necessary information is absent. Future developments in the system can be forecast by analysing the regularity of the time-series values for the technical and economic characteristics of previous periods. The system employs the GM (1.1) prognostic model, which is a `grey` systematic forecasting model with one variable and one linear differential equation. It can be applied to systems which are affected simultaneously be several factors, with no overriding main factor, or in which no marked regularity exists between the controlling factors. The mathematical model constructed on the basis of the `Grey theory` is designed for large-scale economic systems which are affected by several control factors. A bigger system makes for a greater randomness element, which in turn lessens the influence of subjective interference factors and increases the accuracy of the prognosis. (orig./MSK) [Deutsch] Mit Hilfe der Theorie und von Modellen des `grauen Systems` wird eine Prognose der Produktionskosten von chinesischen Bergwerken erstellt. Die Theorie des `grauen Systems` unterscheidet zwischen den von den Menschen beherrschbaren `weissen` Informationen, den von den Menschen nicht beherrschbaren `schwarzen` Informationen und der ueberwiegenden Anzahl der Informationen, die nur teilweise oder nicht vollstaendig erfasst werden koennen und als `graue` Informationen bezeichnet werden. Ein graues System ist folglich ein System, in dem es an notwendigen Informationen fehlt. Die zukuenftige Entwicklung des Systems kann dadurch prognostiziert werden, dass die Regelmaessigkeiten von den Zeitreihenwerten der technischen und wirtschaftlichen Kennziffern vergangener Perioden aufgesucht werden. Angewendet wird das Prognosemodell GM (1,1). GM (1,1) ist ein graues Modell zur systematischen Prognose mit einer Variablen und einer linearen Differentialgleichung. (orig./MSK)

  10. Contribution to the grain refinement of hypoeutectic aluminium-silicon casting alloys: application of a new grain refiner and experience from practice; Beitrag zur Kornfeinung von untereutektischen Aluminium-Silicium-Gusslegierungen: Anwendung eines neuen Kornfeiners und Erfahrungen aus der Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Koch, H. [Aluminium Rheinfelden GmbH, Rheinfelden (Germany)

    2000-10-01

    This paper describes the application of a master alloy on the basis of aluminium-titanium-boron, that is designed for hypoeutectic aluminium-silicon casting alloys. The efficiency of the grain refiner was measured using thermal analysis and sand and permanent mould casted samples. The grain size was measured using metallographic technique. In addition, casting trials using a spiral sand mould were carried out to estimate the influence on the flowing behaviour of the melt. To compare the results, a standard AlTi5B1 rod was used under the same test conditions. Finally, results from practice are shown. The grain refinement mechanism is discussed. (orig.)

  11. Development of an advanced dispersion model for regulatory purposes; Ueberpruefung der Grundlagen der Ausbreitungsrechnung der TA Luft im Hinblick auf eine EG-Harmonisierung: Entwicklung eines fortschrittlichen Ausbreitungsmodells zur Anwendung im Rahmen von Genehmigungsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Scherer, B.; Reimer, E. [Freie Univ. Berlin (Germany). Inst. fuer Meteorologie; Yamartino, R.J. [Earth Tech., Inc., Concord, MA (United States); Klug, W. [Technische Hochschule Darmstadt (Germany). Inst. fuer Meteorologie

    1998-12-01

    A new Lagrangian Particle Model and a meteorological suite to operate the model were developed during phase 1 of the project. The model-system was applied for a long term calculation. The new Kinematic Simulation Particle Dispersion Model (KSP) uses Kinematic Simulation and Monte-Carlo (KS-MC) theory to calculate sub-grid flowfields. It calculates snapshots of concentrations rater then ensemble mean values. It can also directly provide higher moments of concentrations, C{sup (n)}(t) and is applicable for odour problems as well. The model is applicable in a wide spatial (<10-10{sup 3} km) and temporal scale (sec. to years). The meteorological model TRAMPER includes a date archive 3d Objective Analysis with statistical O/I method and a 1-d boundary-layer model as well as prognostic non-hydrostatic model (GESIMA). The analysis provides a three dimensional and time dependent description of relevant meteorological scalar and vector quantities also trajectories in a approx. 30 km grid resolution. Higher resolution is gained by GESIMA (example). As an alternative driver the CALMET Meteorological Model is presented. The evaluation of the KSP will take place in phase 2. Only preliminary results are shown in the report. (orig.) [German] In Phase 1 des Vorhabens wurde ein neues Lagrange - Partikel - Modell (LPM) mit einer meteorologischen Simulationsumgebung (Treiber) entwickelt und fuer eine immissionsklimatologische Berechnung eingesetzt. Das 'Kinematic Simulation Particle' - Ausbreitungsmodell (KSP) arbeitet mit einem subskaligen Stroemungsprozessor nach der 'Kinematic Simulation - Monte Carlo-Methode. Es berechnet Momentanwerte und nicht Ensemblemittelwerte sowie Varianzen und hoehere zeitliche Momente der Konzentration C{sup (n)}(t) und ist fuer die Geruchsausbreitungsrechnung geeignet. Das Verfahren erfasst einen weiten raeumlichen (<10-10{sup 3} km) und zeitlichen Skalenbereich (Sek. bis Jahre). Das meteorologische Modellsystem TRAMPER als Treiber umfasst Datenarchiv, dreidimensionale Objektive Analyse mit statischer Interpolation, 1-d-Grenzschichtmodell und nichthydrostatisches Modell (GESIMA). Erzeugt werden u.a. 3-d-Stroemung, Mischungsschichthoehe und mikrophysikalische Variablen in einem Gitter mit ca. 30 km Aufloesung. Hoehere Aufloesung wird mit GESIMA erzielt (Beispiel) Als alternativer Treiber wird das meteorologische Modell CALMET vorgestellt. Die Evaluierung des KSP ist in der Phase 2 des Vorhabens vorgesehen. Vorlaeufige Ergebnisse koennen in diesem Bericht gezeigt werden. (orig.)

  12. A method for load management in low voltage grids. Application from e-mobility to heat storage; Verfahren zum Lastmanagement in Niederspannungsnetzen. Anwendung von E-Mobility bis Waermespeicher

    Energy Technology Data Exchange (ETDEWEB)

    Hess, Tobias; Schegner, Peter [TU Dresden (Germany). IEEH; Hable, Matthias [ENSO NETZ GmbH, Dresden (Germany)

    2012-07-01

    With the expected charging characteristic of e-mobility a considerable load peak during the night is expected. The paper describes the application of a modified maximal rectangle algorithm to determine the optimal starting times for charging to realise a flat load curve. The load characteristic of e-mobility is similar to heat storage. This allows to use the currently widely spread heat storage devices as example for developing and testing methods for optimized load management in low voltage networks. It is shown that the developed optimization algorithm finds solutions close to the global optimum even in large networks ({approx} 25000 devices) with low requirements of calculation time (< 1 min). (orig.)

  13. A model for the description of the coolant mixing and its application to the analysis of boron dilution transients in pressurized water reactors; Ein Modell zur Beschreibung der Kuehlmittelvermischung und seine Anwendung auf die Analyse von Borverduennungstransienten in Druckwasserreaktoren

    Energy Technology Data Exchange (ETDEWEB)

    Kliem, Soeren

    2010-08-15

    A model for the realistic description of the coolant mixing inside the pressure vessel of a pressurized water reactors has been developed and validated. This fast running model is based on the linear superposition of response functions on Dirac-pulse-like perturbations of the coolant parameters. It has been implemented into the coupled code system DYN3D/ATHLET nad serves as the interface between the one-dimensional thermal hydraulic system code ATHLETE and the 3D neutron kinetic core model DYN3D. By help of this model, the coolant mixing inside the reactor pressure vessel can e simulated in an efficient manner. A methodology for this analysis of hypothetical boron dilution accidents has been developed, which is based on the newly developed model for the coolant mixing. This methodology consists of a combination of stationary and transient calculations including a realistic treatment of the mixing of deborated slugs on the way towards the reactor core. The degree of conservatism can be adjusted by the variation of the initial size of the deborated slug. This new method was applied to two different boron dilution accidents. Besides the start of the first main coolant pump with a deborated slug of coolant in the cold leg of the primary circuit, a deboration event during the operation of the residual heat removal system was investigated. The results of the parameter study for a reactor core with a generic loading pattern demonstrated in both cases, that although the shut-down reactor becomes re-critical safety relevant cladding temperature limits are not reached, even if maximum possible volumes of the deborated slug are considered. The main reason for these results is the use of realistic time-dependent distributions of the boron concentration at the inlet of each fuel assembly.

  14. Development and application of a tree-code in simulation scenarios of the plasma-wall interaction; Entwicklung und Anwendung eines Tree-Codes in Simulationsszenarios der Plasma-Wand-Wechselwirkung

    Energy Technology Data Exchange (ETDEWEB)

    Berberich, Benjamin

    2012-03-15

    Processes in the plasma edge layer of magnetic fusion devices occur on widely disparate length- and time-scales. Also recently developed features in this particular region, such as stochastic magnetic fields, underline the necessity for three dimensional, full-kinetic simulation tools. Contemporary programs often deploy ad hoc assumptions and approximations for microscopic phenomena for which self-consistent ab initio models in principle exist, but are still computationally too expensive or complex to implement. Recently, mesh-free methods have matured into a new class of tools for such first-principles computations which thanks to their geometric flexibility are highly promising for tackling complicated TOKAMAK regions. In this work we have develop the massively parallel Tree-Code PEPC-B (Pretty Efficient Parallel Coulomb solver) into a new tool for plasma material interaction studies. After a brief overview of the working principles of Tree-Codes two main topic groups are addressed: First the leap-frog Boris integration scheme is discussed and its numerical limitations are pointed out. To overcome these limitations the method is enhanced to a guiding-center integrator. As a proof of principal, numerical experiments are conducted reproducing the anticipated drift kinetic aspects of particle orbits. It turns out that this new technique is much less sensitive to large time steps than the original concept was. One major drawback of mesh-free methods which hinders their direct use for plasma-edge simulations is the difficulty in representing solid structures and associated boundary conditions. Therefore, an alternative concept is proposed using charge carrying Wall-Particles, which fits naturally in the mesh-free doctrine. These developments incorporate the second main topic group of this report. To prove the physical correctness of this new idea, a quasi one dimensional plasma-wall interface scenario is chosen. By studying the system with great detail, good agreement between numerical findings and semi-analytical results from the literature is achieved. After that verification a broad set of physical parameters are reviewed and corresponding scenarios evaluated. Explicitly the work focuses on the ion kinetics at the sheath edge. Numerical findings in that particular region compare well to established benchmarks in the collisionless limit. Furthermore results with rotated magnetic fields are presented. In the underlying simulations the newly developed guiding-center integrator is applied. Dedicated comparisons of the findings show good agreement with former theoretical and numerical approaches. A significant strength of the self-consistent mesh-free concept is its natural capability for including close range Coulomb interactions among charged particles. In this way it is possible, to consider intrinsically collisional scenarios such as the effect of ion-ion collisions on the presheath. Additionally a new developed Monte-Carlo background-scatter-scheme is utilized to introduce charge-exchange collisions into the presheath kinetics of the ions. These last two analyses show little change in sheath-relevant quantities. So the presented results support the widely held view that a viscosity or collisional dominated presheath has little effect on the sheath itself.

  15. Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, R.; Stuecklschweiger, G.F.; Prettenhofer, U.; Stranzl, H.; Hackl, A. [Univ. Graz (Austria). Dept. of Radiotherapy; Beham-Schmid, C. [Univ. Graz (Austria). Dept. of Pathology; Groell, R. [Univ. Graz (Austria). Dept. of Radiology; Smolle-Juettner, F.M.; Renner, H. [Univ. Graz (Austria). Dept. of Thoracic and Hyperbaric Surgery; Quehenberger, F. [Univ. Graz (Austria). Dept. of Medical Informatics, Statistics and Documentation

    1999-06-01

    krankheitsfreies Ueberleben von 63,7% (95%-Konfidenzintervall [KI] 42 bis 84%), 88,3% (KI 75 bis 100%) sowie 77,4% (KI 58 bis 95%). Bei den untersuchten prognostischen Faktoren, wie Alter, Myasthenia gravis, chirurgische Radikalitaet, histologische Subgruppe, Bestrahlungsdosis und Masaoka-Stadium, hatte nur letzteres einen statistisch signifikanten Einfluss`` auf das Ueberleben (p=0.04). Bei alleiniger Beruecksichtigung der lokalen Kontrolle war die Bestrahlungsdosis ein statistisch signifikanter prognostischer Parameter (p=0,0006). Patienten mit Thymuskarzinom (mediane Nachsorgezeit 43,3 Monate) hatten ein krankheitsspezifisches und krankheitsfreies Fuenf-Jahres-Ueberleben von 22,2% (KI 0 bis 60%) sowie 16,7% (KI 0 bis 46%). Patienten mit Thymomen hatten im Vergleich zu Patienten mit Thymuskarzinomen sowohl ein statistisch signifikant besseres krankheitsspezifisches (p=0,007) als auch krankheitsfreies Ueberleben (p=0,0007). Schlussfolgerung: Postoperative Strahlentherapie mit adaequater Dosis spielt eine wichtige Rolle als adjuvante Therapie bei inkomplett und komplett resezierten invasiven Thymomen Stadium II bis III. Bei primaer inoperablen Thymomen und bei Thymuskarzinom sollte ein multimodales Vorgehen in Erwaegung gezogen werden, um die Ueberlebensraten zu verbessern. (orig.)

  16. Short-term hypofractionated radiotherapy followed by total mesorectal excision; Kleinvolumige hypofraktionierte Radiotherapie vor totaler mesorektaler Exzision

    Energy Technology Data Exchange (ETDEWEB)

    Lammering, G. [Duesseldorf Univ. (Germany). Klinik fuer Strahlentherapie und Radioonkologie; Medical Coll. of Virginia., Richmond, VA (United States). Dept. of Radiation Oncology; Hartmann, K.A.; Aryus, B.; Doeker, R. [Duesseldorf Univ. (Germany). Klinik fuer Strahlentherapie und Radioonkologie; Frenken, M.; Ulrich, B. [Staedtische Kliniken Duesseldorf-Gerresheim (Germany). Chirurgische Klinik

    2000-12-01

    As of December 1996 to March 1999, 34 patients with locally advanced rectal cancer have been irradiated preoperatively with 5 times 5 Gy. After CT-planning, radiotherapy was administered using a 3-field or 4-field box technique with 2 anterior-posterior fields or a posterior field of 9 {+-} 2 cm x 11.5 {+-} 2.4 cm and 2 opposed bilateral fields of 9 {+-} 1.5 cm x 11.5 {+-} 2 cm with 6- to 25-MV photons. Surgery was performed 14 {+-} 6 days after irradiation in 33/34 patients (82% anterior resection with total mesorectal excision, 18% abdomino-perineal resection). Patients with a positive lymph node status or pT3/4 lesions underwent adjuvant chemotherapy with 5-Fluorouracil (5-FU). The median follow-up period is 189 days (range: 15 to 548 days). Results: The following early side reactions were registered: Increased bowel movements (4/34), fatigue (2/34), pain in the groins (1/34), nausea and perianal smart (1/34), vertigo (1/34), temporary urinary obstruction (1/34). One patient with heart failure NYHA Grade III died of a heart attack after 21 days. Preoperative T and N categories showed a distribution of 3,29 and 2 for T4, T3 and unknown and 20, 11 and 3 for N+, N- and unknown; postoperative T and N categories showed a distribution of 3/19 and 11 for T4, T3 and T2 and 19 and 14 for N+ and N-. In 32 of 33 patients tumor free margins were achieved. One patient with peritoneal metastases had a R1 resection. In 3 patients metastases were detected intraoperatively. Perioperative complications were: 2 cases of leaking anastomosis and postoperative bowel atonia, 1 case with bowel obstruction, delayed wound healing, wound dehiscence and temporary renal dysfunction. (orig.) [German] Von Dezember 1996 bis Maerz 1999 wurden 34 Patienten mit lokal fortgeschrittenem Rektumkarzinom einer praeoperativen Strahlentherapie mit 5-mal 5 Gy zugefuehrt. Die kleinvolumige Bestrahlung erfolgte in CT-geplanter Drei- oder Vier-Felder-Technik mit ventrodorsalen Gegenfeldern bzw. dorsalen

  17. Dose-dependent changes in renal {sup 1}H-/{sup 23}Na MRI after adjuvant radiochemotherapy for gastric cancer

    Energy Technology Data Exchange (ETDEWEB)

    Haneder, Stefan [University Medical Centre Mannheim, University of Heidelberg, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); University Hospital of Cologne, Department of Radiology, Cologne (Germany); Budjan, Johannes Michael; Schoenberg, Stefan Oswald [University Medical Centre Mannheim, University of Heidelberg, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); Konstandin, Simon; Schad, Lothar Rudi [University Medical Centre Mannheim, University of Heidelberg, Computer Assisted Clinical Medicine, Mannheim (Germany); Hofheinz, Ralf Dieter [University Medical Centre Mannheim, University of Heidelberg, III. Department of Internal Medicine, Mannheim (Germany); Gramlich, Veronika; Wenz, Frederik; Lohr, Frank; Boda-Heggemann, Judit [University Medical Centre Mannheim, Medical Faculty Mannheim - University of Heidelberg, Department of Radiation Oncology, Mannheim (Germany)

    2015-04-01

    .043). No participants showed clinical renal impairment. Functional parameters of renal {sup 23}Na MRI after gastric IG-IMRT are identical to those of healthy volunteers, in contrast to renal subvolumes after ablative doses in the control and 3D-CRT patient. While kidney doses to the cortex below 20-25 Gy in fractional doses of ∝ 1 Gy in IG-IMRT (combined with intensified chemotherapy) do not seem to cause significant MRI morphological or functional alterations, doses of > 35 Gy in 1.5-2 Gy fractions clearly result in impairment. (orig.) [German] Die Radiochemotherapie (RCT) des Magenkarzinoms mit 3-dimensionaler konformaler Strahlentherapie (3D-CRT) belastet den linken Nierenoberpol mit ablativen Strahlendosen. Die bildgefuehrte, intensitaetsmodulierte Strahlentherapie (IG-IMRT) ermoeglicht die Aussparung des Nierenparenchyms bei verbesserter Zielvolumenabdeckung. Die Nierenfunktion wurde mit 3 T-funktioneller MRT (diffusionsgewichtete Bildgebung; DWI) und {sup 23}Na-Bildgebung in einer Kohorte von Patienten mit langem Follow-up ausgewertet. Es wurden 5 gesunde Probanden (HV) und 12 Patienten mit Magenkarzinom (11-mal IG-IMRT; 1-mal 3D-CRT) sowie ein Patient als ''positive-Kontrolle'' (nach Behandlung einerMetastase zwischen Milz und linker Niere mit SBRT [''stereotactic-body-radiotherapy'']) untersucht. Die Bestrahlungsdosen wurden fuer die oberen, mittleren und unteren Nierenetagen getrennt dokumentiert. Spaettoxizitaet wurde basierend auf den allgemeinen Toxizitaetskriterien (CTC, Common Toxicity Criteria), mittels Fragebogen und anhand der Kreatininwerte bestimmt. Morphologische Sequenzen, DWI- und {sup 23}Na-Bilder wurden mit einer {sup 1}H/{sup 23}Na-Spule vor und nach intravenoeser Fluessigkeitszufuhr (''water load'', WL) akquiriert. Die statistische Auswertung erfolgte fuer [{sup 23}Na]-Konzentration und ADC (''apparent diffusion coefficient'')-Werte getrennt nach Subvolumina (obere

  18. Vertically transmitted HPV-dependent squamous cell carcinoma of the external auditory canal. Case report of a child

    Energy Technology Data Exchange (ETDEWEB)

    Snietura, Miroslaw; Pakulo, Slawomir; Kopec, Agnieszka; Piglowski, Wojciech; Stanek-Widera, Agata [Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Tumor Pathology Department, Gliwice (Poland); Chelmecka-Wiktorczyk, Liliana [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Drabik, Grazyna [University Children' s Hospital of Cracow, Pathology Department, Cracow (Poland); Kosowski, Bogdan [NZOZ Prosmed, Cracow (Poland); Wyrobek, Lukasz [University Children' s Hospital of Cracow, Department of Radiology, Cracow (Poland); Balwierz, Walentyna [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Jagiellonian University in Cracow, Clinic of Oncology and Hematology, Polish-American Pediatric Institute, Cracow (Poland)

    2017-02-15

    -negative Tumoren des Kopf- und Halsbereichs treten vor allem bei Erwachsenen auf und sind bei Kindern eine Seltenheit. Daher begruendete die Diagnose eines Plattenepithelkarzinoms des aeusseren Gehoergangs bei einem 2-jaehrigen Kind die Notwendigkeit, die Krankheit eingehend zu untersuchen und zu beschreiben. Wir berichten ueber ein 2-jaehriges Maedchen, das von einer HPV-positiven Mutter geboren wurde, bei der waehrend der Schwangerschaft Gebaermutterhalskrebs diagnostiziert worden war. Die Geburt erfolgte per Kaiserschnitt. Die Mutter erlag 7 Monate nach der Geburt ihrer Krebserkrankung. Das Kind wurde nach der Diagnose eines lokal fortgeschrittenen HPV-positiven Plattenepithelkarzinoms des aeusseren Gehoergangs operativ und ergaenzend mit Radio- und Chemotherapie behandelt. Erreicht wurde eine komplette Remission fuer mindestens 325 Wochen nach Beginn der Behandlung, sodass mehr als 6 Jahre keine Krankheitssymptome aufgetreten sind. Dies ist die erste Fallbeschreibung eines stark fortgeschrittenen HR-HPV-positiven HNSCC des aeusseren Gehoergangs bei einem 2-jaehrigen Kind, bei dem nach Anwendung einer nichtradikalen chirurgischen Behandlung sowie einer Chemo- und Strahlentherapie eine spektakulaere Reaktion und ein aktuell 6-jaehriges krankheitsfreies Ueberleben erreicht wurden. Dieser Fall bestaetigt die Beobachtungen, nach denen HNSCC-Tumoren im Zusammenhang mit HR-HPV guenstig auf die Behandlung ansprechen - trotz des klinisch fortgeschrittenen Tumorstadiums und des jungen Patientenalters. (orig.)

  19. Impact of a rectal and bladder preparation protocol on prostate cancer outcome in patients treated with external beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Maggio, A.; Bresciani, S.; Di Dia, A.; Miranti, A.; Poli, M.; Stasi, M. [Candiolo Cancer Institute - FPO, IRCCS, Medical Physic Department, Candiolo (Italy); Gabriele, D. [Candiolo Cancer Institute - FPO, IRCCS, Radiotherapy Department, Candiolo (Italy); University of Sassari, Division of Radiation Oncology, Sassari (Italy); Garibaldi, E.; Delmastro, E.; Gabriele, P. [Candiolo Cancer Institute - FPO, IRCCS, Radiotherapy Department, Candiolo (Italy); Varetto, T. [Candiolo Cancer Institute - FPO, IRCCS, Nuclear Medicine Department, Candiolo (Italy)

    2017-09-15

    To test the hypothesis that a rectal and bladder preparation protocol is associated with an increase in prostate cancer specific survival (PCSS), clinical disease free survival (CDFS) and biochemical disease free survival (BDFS). From 1999 to 2012, 1080 prostate cancer (PCa) patients were treated with three-dimensional conformal radiotherapy (3DCRT). Of these patients, 761 were treated with an empty rectum and comfortably full bladder (RBP) preparation protocol, while for 319 patients no rectal/bladder preparation (NRBP) protocol was adopted. Compared with NRBP patients, patients with RBP had significantly higher BDFS (64% vs 48% at 10 years, respectively), CDFS (81% vs 70.5% at 10 years, respectively) and PCSS (95% vs 88% at 10 years, respectively) (log-rank test p < 0.001). Multivariate analysis (MVA) indicated for all treated patients and intermediate high-risk patients that the Gleason score (GS) and the rectal and bladder preparation were the most important prognostic factors for PCSS, CDFS and BDFS. With regard to high- and very high-risk patients, GS, RBP, prostate cancer staging and RT dose were predictors of PCSS, CDFS and BDFS in univariate analysis (UVA). We found strong evidence that rectal and bladder preparation significantly decreases biochemical and clinical failures and the probability of death from PCa in patients treated without daily image-guided prostate localization, presumably since patients with RBP are able to maintain a reproducibly empty rectum and comfortably full bladder across the whole treatment compared with NRPB patients. (orig.) [German] Pruefung der Hypothese, dass ein Rektum-Blasen-Vorbereitungsprotokoll mit einer Zunahme des prostatakarzinomspezifischen Ueberlebens (PCSS), des klinisch krankheitsfreien Ueberlebens (CDFS) und des biochemisch krankheitsfreien Ueberlebens (BDFS) verbunden ist. Von 1999 bis 2012 erhielten 1080 Patienten mit Prostatakarzinom eine 3-dimensional geplante Strahlentherapie. Bei 761 Patienten wurde ein

  20. Clinical indications and biological mechanisms of splenic irradiation in autoimmune diseases

    Energy Technology Data Exchange (ETDEWEB)

    Weinmann, M.; Becker, G. [Tuebingen Univ. (Germany). Abt. fuer Strahlenonkologie; Einsele, H.; Bamberg, M. [Tuebingen Univ. (Germany). Abt. fuer Innere Medizin 2

    2001-02-01

    Autoimmunerkrankungen wie den autoimmun haemolytischen Anaemien (AIHA) oder den autoimmun vermittelten Thrombozytopenien (AIT) ist eine wenig bekannte Therapieoption. Die klinische Erfahrung und das Wissen um die zugrunde liegenden biologischen Mechanismen sind begrenzt. Trotzdem profitieren Patienten in bestimmten klinischen Konstellationen von der Milzbestrahlung. Patienten und Methode: Diese Uebersichtsarbeit fasst die bisherigen Erfahrungen zur Milzbestrahlung bei der autoimmun vermittelten Thrombozytopenie - sieben Studien und zwei Fallberichte mit insgesamt 71 Patienten - zusammen und berichtet ueber die bisher eher anekdotischen Erfahrungen zur Milzbestrahlung im Falle einer autoimmun haemolytische Anaemie. Ergebnisse: Zwischen 40 und 90% aller Patienten mit autoimmun vermittelten Thrombozytopenien sprachen auf die Bestrahlung der Milz an, wobei allerdings die meisten kurz nach Ende der Therapie wieder einen Abfall der Thrombozytenzahl erlitten. Etwa 10 bis 20% aller Patienten profitierten langfristiger von der Behandlung, wobei Patienten mit einer HIV-assoziierten Thrombozytopenie moeglicherweise etwas schlechter ansprechen. Einzelne Fallberichte schildern auch erfolgreiche Behandlungen von autoimmun haemolytischen Anaemien durch Bestrahlung der Milz. Die Nebenwirkungen der Milzbestrahlung waren in allen ausgewerteten Studien sehr moderat. Schlussfolgerungen: In Risikokonstellationen fuer eine Splenektomie oder bei Resistenz gegenueber medikamentoesen Ansaetzen kann die Milzbestrahlung bei ausgewaehlten Patienten eine wertvolle Alternative bei der Therapie der Autoimmunthrombopenie darstellen. Eine viel versprechende neue Anwendung koennte moeglicherweise die praeoperative, akzelerierte Milzbestrahlung vor Splenektomie bei Patienten darstellen, die auf immunsuppressive Medikamente schlecht oder gar nicht ansprechen. Ein Verstaendnis der immunsuppressiven Effekte der Milzbestrahlung koennte in Zukunft die Grundlage optimierter Dosiskonzepte und einer besseren Patientenselektion

  1. Influence of spray nozzles and adjuvants in drift reduction potential in wind tunnel
    Influência de pontas de pulverização e adjuvantes no potencial de redução de deriva em túnel de vento

    OpenAIRE

    Rodolfo Glauber Chechetto; Ulisses Rocha Antuniassi; Alisson Augusto Barbieri Mota; Fernando Kassis Carvalho; Anne Caroline Arruda e Silva; Caroline Michels Vilela

    2013-01-01

    The drift is intimately linked to inappropriate use of pesticides and an important factor for reducing it, is the correct selection of spray nozzles and adjuvants. The objective of this work was to evaluate the drift potential in wind tunnel with different spray nozzles and different concentrations of adjuvants. The experiment was composed by six spray solutions (vegetable oil (in three concentrations), mineral oil, surfactant and reducing drift), which were applied with two nozzles, one pre-...

  2. Potential economic impact of the 21-gene expression assay on the treatment of breast cancer in brazil Potencial impacto econômico do painel de expressão de 21 genes no tratamento adjuvante do câncer de mama no Brasil

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Bacchi

    2010-01-01

    Full Text Available OBJECTIVE: The 21-gene expression assay may support the decision regarding use of chemotherapy in early breast cancer. We sought to investigate the potential impact of incorporating the 21-gene expression assay into private practice in Brazil, from the perspective of third party payers. METHODS: We conducted a web-based survey with 30 (of a total of approximately 700 Brazilian medical oncologists, who were stratified by State according to the proportion of patients with breast cancer and private health insurance. We evaluated the possible treatment of first choice for patients with lymph-node-negative, estrogen-receptor-positive breast cancer, regardless of menopausal status. Interviewees were not aware of the objective of the study. Responses permitted a quantitative assessment of the care patterns regarding use of different chemotherapy regimens, type of premedication, use of growth factors, and use of intravenous antibiotics for febrile neutropenia. We calculated medication costs using the manufacturer's recommended prices. Other direct medical expenses, indirect medical costs, and non-medical costs were not included. RESULTS: Considering a hypothetical cohort of 100 patients without access to the 21-gene expression assay, the survey showed that 84 patients would receive chemotherapy. Reclassifying patient eligibility for chemotherapy according to the 21-gene expression assay would lower this number to 49. For a hypothetical cohort of 100 patients with access to the test, US$ 79,361.43 would be saved in main direct medical costs. Such results, however, would greatly vary according to tumor size: the 21-gene expression assay could increase direct medical costs in T1 tumors, and decrease costs in cases with T >2 cm. CONCLUSION: Considering the current price for the 21-gene expression assay in Brazil, our economic analysis suggests that such testing is an overall cost-saving, from the perspective of third party payers. Further, optimal use of resources would entail targeted use of the 21-gene expression assay.OBJETIVO: O índice de recorrência (IR, também conhecido como painel de 21 genes, pode apoiar decisões com relação ao uso de quimioterapia (QT no câncer de mama precoce. Procuramos investigar o impacto potencial da incorporação do IR na prática privada no Brasil, a partir da perspectiva das fontes pagadoras. MÉTODOS: Conduzimos uma pesquisa com 30 oncologistas brasileiros (de um total de aproximadamente 700, que foram estratificados por Estado de acordo com a proporção de pacientes com câncer de mama e com cobertura pelo sistema de saúde suplementar. Avaliamos o tratamento de primeira escolha para pacientes com câncer de mama com axila negativa e expressão positiva do receptor de estrógeno, independente do estado menopausal. Os entrevistados não estavam cientes do objetivo do estudo. As respostas permitiram uma avaliação quantitativa dos padrões de cuidado, considerando o uso de diferentes regimes de QT, o tipo de pré-medicações, o uso de fatores de crescimento e o tratamento hospitalar da neutropenia febril. Calculamos o custo dos medicamentos usando o Brasíndice, e o custo do IR foi fixado em R$ 3.900,00 (MammaGene®. Outras despesas médicas diretas, custos médicos indiretos e custos não-médicos não foram considerados. RESULTADOS: Numa corte hipotética de 100 pacientes sem acesso ao teste de IR, 84 iriam receber quimioterapia. Reclassificando a elegibilidade das pacientes para QT de acordo com o IR, esse número cairia para 49. Para uma coorte hipotética de 100 pacientes com acesso ao IR, seriam economizados R$ 134.915,00 em despesas médicas diretas. CONCLUSÃO: Considerando o preço atual para avaliação do IR no Brasil, nossa análise econômica sugere que este teste economizaria custos, pela perspectiva das fontes pagadoras do setor privado. Além disso, o uso otimizado de recursos poderia requerer o emprego do painel de 21 genes de forma racional.

  3. Locoregional recurrence in patients suffering from a triple-negative breast cancer: interest of a systematic adjuvant ganglionary irradiation; Recidives locoregionales chez les patientes atteintes d'un cancer du sein triple-negatif: interet d'une irradiation ganglionnaire adjuvante systematique?

    Energy Technology Data Exchange (ETDEWEB)

    Clerc, J.; Sunyach, M.P.; Duruisseaux, M.; Mignotte, H.; Bajard, A.; Tredan, O.; Carrie, C.; Arnaud, A. [Centre Leon-Berard, Lyon (France)

    2011-10-15

    The authors report the assessment of locoregional recurrence percentage within women suffering from a triple-negative breast cancer without ganglionary attack, in order to examine the interest of a systematic adjuvant ganglionary irradiation. Nearly 250 women have been treated for a breast cancer between 1999 and 2009 in the Leon-Berard Centre in Lyons. All had surgery followed or not by a chemotherapy and/or a radiotherapy. The locoregional recurrence rate is not very high, but the authors cannot yet be sure to systematically propose this treatment. Short communication

  4. Transversal escharotomies: a new surgical technique adjuvant in the treatment of chronic ulcers with non-arterial etiology in the lower limbs Escarotomias transversais: uma nova opção cirúrgica adjuvante no tratamento de úlceras crônicas de etiologia não arterial em membros inferiores

    Directory of Open Access Journals (Sweden)

    Mário Augusto Silva Freitas

    2006-01-01

    Full Text Available PURPOSE: Propose a new and alternative surgical procedure in order to aid on treatments of chronic ulcers with non-arterial etiology in the lower limbs, especially those that reoccurs and accomplish of dermatosclerosis and skin contractures determining ankle and foot limits. METHODS: It describes a medical case regarding a female, 54 years old, with a pre-existing ulcer (sixteen years on her left leg. Despite of conventional treatments such as curatives, compressive therapy and surgeries, the ulcer on her leg was not cured for three years. The skin dermatosclerosis on her foot and ankle limited her mobility tremendously. The surgery involved the debridement of the ulcers, local phlebectomies and the correction of her scar contraction by a transversal escharotomies. Conventional procedures were applied in pre and post-surgery. RESULTS: After twelve weeks, the ulcer was completely healed by second intention. Despite the odds, she regained sustainable mobility in her foot and ankle, allowing this patient to wear medical elastic socks. Reoccurrences of the ulcer did not occur during the two years post-surgery. CONCLUSION: The transversal escharotomies may favor the healing of non-arterial chronic ulcers in the lower limbs, impeding perpetual mechanisms of this sort. For example, the ankle and foot limitation determinates in secondary scars, skin contractures, dermatosclerosis that produce the failure in the muscular calf-pump with deterioration in the ascending venous propulsion.OBJETIVO: Apresentar uma nova alternativa cirúrgica para auxiliar o tratamento de úlceras crônicas de etiologia não arterial em membros inferiores, especialmente aquelas com recidivas e complicadas por contraturas de pele, limitando movimentos do pé e tornozelo. MÉTODOS: Descrição de caso de uma paciente portadora de úlcera em perna esquerda com dezesseis anos de evolução, múltiplas recidivas, sem cicatrização há três anos apesar de curativos convencionais, terapias compressivas e cirurgias. As contraturas cicatriciais e a dermatoesclerose local limitavam a marcha pela redução da mobilidade do pé e tornozelo. A cirurgia realizada foi o debridamento tangencial da úlcera, flebectomias locais e a correção das contraturas de pele por meio das escarotomias transversais. Após a cirurgia foram mantidos os mesmos padrões de curativos e a terapia compressiva utilizada no pré-operatório. RESULTADOS: Houve cicatrização completa da úlcera, por segunda intenção, doze semanas após a cirurgia com ganho importante na amplitude dos movimentos do pé e tornozelo, permitindo normalização da marcha e adaptação ao uso de meias elásticas terapêuticas. Não houve recidiva em dois anos de acompanhamento pós-operatório. CONCLUSÃO: Esta técnica parece favorecer a cicatrização de úlceras crônicas de etiologia não arterial atuando em mecanismos perpetuadores do processo, como, por exemplo, a limitação da propulsão venosa pela musculatura da panturrilha determinada por contraturas cicatriciais e pela dermatoesclerose do pé e tornozelo.

  5. Caracterização das propriedades funcionais e probióticas de bactérias láticas isoladas de cães para uso em vacinas orais contra leptospirose como adjuvante imune ou carreador antigênico

    OpenAIRE

    Lenice Roteia Cardoso Jung

    2013-01-01

    A leptospirose canina tem aumentado significativamente nos últimos anos. No Brasil alguns estudos têm demonstrado o caráter endêmico dessa zoonose em cães e que estes animais podem exibir o status de portadores renais crônicos da Leptospira. A exposição e o convívio do homem com os cães poderão torná-lo vulnerável à infecção por Leptospira. Na intenção de desenvolver uma vacia oral contra a leptospirose canina busca-se avaliar a possibilidade de usar lactobacilos autóctones como veículos ou a...

  6. Optimization by visualization of indices

    Energy Technology Data Exchange (ETDEWEB)

    Haverkamp, Uwe; Kriz, Jan; Eich, Hans Theodor [University Muenster, Department of Radiotherapy, Muenster (Germany); Norkus, Darius [Vilnius University, Oncology Institute, Vilnius (Lithuania); Mueller Minai, Mariam; Prott, Franz-Josef [RNS Radiotherapy Wiesbaden, Wiesbaden (Germany)

    2014-11-15

    exposure of normal tissue volumes. The calculated F values correlated with these observations. An evaluation of dose distributions cannot be based on a single conformal index. A solution could be the use of several indices presented as a hexagonal graphic and/or as a test function. (orig.) [German] Die physikalische 3-D-Bestrahlungsplanung liefert eine Fuelle an Parametern zur Beschreibung der Dosisverteilung. Um zu einer schnellen Evaluation zu kommen, kann es sinnvoll sein, Konformationsindizes zu verwenden. Allerdings ist deren Anwendung umstritten und nicht immer effektiv. Es ist das Ziel dieser Studie, einen Quick-Check zu entwickeln, um Unterdosierungen im Zielvolumen (PTVs) und Ueberdosierungen im Normalgewebe zu detektieren. Von 215 Patienten wurden die Dosisverteilungen betrachtet. Therapiemodalitaeten waren die 3-dimensionale konformale Strahlentherapie (3D-CRT), Radiochirurgie, die intensitaetsmodulierte Strahlentherapie (IMRT), die intensitaetsmodulierte Arc-Therapie (IMAT) und die Tomotherapie. Fuer die Planung wurden die in ICRU 50 und 83 vorgeschlagenen Volumen verwendet und entsprechend einer Literaturanalyse 6 Konformations- und Homogenitaetsindizes ausgewaehlt (CI, CN, C{sub ICRU}, COV, C{sub ∇}, and HI), deren Definitionen auf dem PTV, dem Behandlungsvolumen (TV{sub PI}), dem Partialvolumen (PI, PTV{sub PI}), dem Maximum D2 und dem Minimum D98 basieren. Die Ergebnisse werden in Form eines Hexagons praesentiert, deren Ecken die Werte der Indizes repraesentieren, zusaetzlich werden die Werte einer modifizierten Test-Funktion F (Rosenbrock-Funktion) berechnet. Im Rahmen dieser Arbeit werden klinische Beispiele und Mittelwerte betrachtet, um die Moeglichkeiten der hier vorgestellten Evaluation im Detail und allgemein betrachten zu koennen. IMAT und Tomotherapie zeigen die besten Mittelwerte gefolgt von der IMRT. 3DCRT und Radiochirurgie (Z. B. CN: IMAT 0,85 ± 0,06; Tomotherapie 0,84 ± 0,06; IMRT 0,83 ± 0,07; 3DCRT 0,65 ± 0,08; Radiochirurgie 0,64 ± 0

  7. Left-sided breast cancer and risks of secondary lung cancer and ischemic heart disease. Effects of modern radiotherapy techniques

    Energy Technology Data Exchange (ETDEWEB)

    Corradini, Stefanie; Ballhausen, Hendrik; Weingandt, Helmut; Freislederer, Philipp; Schoenecker, Stephan; Niyazi, Maximilian; Belka, Claus [University Hospital, LMU Munich, Department of Radiation Oncology, Munich (Germany); Simonetto, Cristoforo; Eidemueller, Markus [Helmholtz Zentrum Muenchen, Institute of Radiation Protection, Neuherberg (Germany); Ganswindt, Ute [University Hospital, LMU Munich, Department of Radiation Oncology, Munich (Germany); Medical University, Department of Radiation Oncology, Innsbruck (Austria)

    2018-03-15

    risk for both major coronary events and secondary lung cancer. (orig.) [German] Moderne Strahlentherapietechniken, wie die Bestrahlung in tiefer Inspiration (DIBH) oder die volumenmodulierte Rotationstherapie (VMAT), koennen die hohe Dosisbelastung des Herzens bei der Bestrahlung von linksseitigem Brustkrebs deutlich verringern. Ziel dieser Planungsstudie war es zu untersuchen, inwieweit unterschiedliche Bestrahlungstechniken bei linksseitigem Brustkrebs das relative und absolute Risiko fuer strahleninduzierte Sekundaermalignome der Lunge und schwere koronare Herzerkrankungen beeinflussen. Es wurden jeweils 4 Bestrahlungsplaene fuer Computertomographiedatensaetze von 10 Patientinnen mit linksseitigem Mammakarzinom generiert: eine tangentiale 3-dimensionale konformale Strahlentherapie (3D-CRT) und eine volumenmodulierte Strahlentherapie (VMAT), jeweils in Ruheatmung (FB) und DIBH. Die Parameter der Dosis-Volumen-Histogramme (DVH) wurden zur Berechnung der ''organ equivalent dose'' (OED) herangezogen, dabei wurde ein lineares, linear-exponentielles sowie ein Plateaumodell fuer die Lunge angewendet. Hiermit wurden das relative Risiko (''excess relative risk'' [ERR]) und das absolute 10-Jahres-Risiko (''excess absolute risk'' [EAR]) von strahleninduzierten Sekundaermalignomen der Lunge und koronaren Herzerkrankungen fuer unterschiedliche repraesentative Baseline-Risiken berechnet. Durch die Bestrahlung in tiefer Inspiration zeigte sich ein deutlicher Vorteil bezueglich des absoluten 10-Jahres-Risikos schwerer koronarer Ereignisse fuer die 3D-CRT im Vergleich zur Ruheatmung (p = 0,04). Fuer die VMAT war die Risikoreduktion durch DIBH insgesamt geringer und statistisch nicht signifikant (p = 0,44). Das strahleninduzierte 10-Jahres-Risiko fuer Sekundaermalignome der Lunge wurde vorwiegend durch die Wahl der Strahlentherapietechnik und nicht durch die Anwendung eines Atemanhaltemanoevers beeinflusst. Fuer VMAT zeigte

  8. Neuro-Enhancement — klinische, soziale und ethische Dimensionen: Kognitive Leistungssteigerung in Kindheit und Jugend

    NARCIS (Netherlands)

    Nagel, S.K.; Nagel, Saskia Kathi

    2015-01-01

    Der als Neuro-Enhancement bezeichnete Einsatz meist verschreibungspflichtiger Medikamente oder Technologien zur Steigerung kognitiver Leistungen und Verbesserung affektiver Zustände bei Gesunden findet in den letzten Jahren vermehrt Anwendung. Skeptiker befürchten allerdings eine zunehmende

  9. Chemical gas sensors based on functionalized self-actuated piezo-resistive cantilevers

    OpenAIRE

    Filenko, Denys

    2008-01-01

    Der Schwerpunkt dieser Arbeit liegt in der Anwendung funktionalisierter Mikrocantilever mit integrierter bimorpher Aktuation und piezo-resistiver Detektion als chemische Gassensoren für den schnellen, tragbaren und preisgünstigen Nachweis verschiedener flüchtiger Substanzen. Besondere Beachtung erfährt die Verbesserung der Cantilever-Arbeitsleistung durch den Betrieb in speziellen Modi. Weiterer Schwerpunkt liegt in der Untersuchung von spezifischen Sorptionswechselwirkungen und Anwendung von...

  10. Breast conserving treatment of breast carcinoma T2 ({<=} 4 cm) and T3 by neoadjuvant chemotherapy, quadrantectomy, high dose rate brachytherapy as a boost, external beam radiotherapy and adjuvant chemotherapy: local control and overall survival analysis; Tratamento conservador do cancer de mama T2 ({<=} 4 cm) e T3 por quimioterapia neoadjuvante, quadrantectomia, braquiterapia com alta taxa de dose como reforco de dose, teleterapia complementar e quimioterapia adjuvante: analise de controle local e sobrevida global

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Celia Regina; Miziara Filho, Miguel Abrao; Fogaroli, Ricardo Cesar; Baraldi, Helena Espindola; Pellizzon, Antonio Cassio Assis; Pelosi, Edilson Lopes [Instituto do Cancer Dr. Arnaldo Vieira de Carvalho (ICAVC), Sao Paulo, SP (Brazil). Servico de Radioterapia], e-mail: celiarsoares@terra.com.br; Fristachi, Carlos Elias [Instituto do Cancer Dr. Arnaldo Vieira de Carvalho (ICAVC), Sao Paulo, SP (Brazil). Servico de Onco-Ginecologia e Mastologia; Paes, Roberto Pinto [Instituto do Cancer Dr. Arnaldo Vieira de Carvalho (ICAVC), Sao Paulo, SP (Brazil)

    2008-12-15

    Objective: to assess the treatment of breast cancer T2 ({<=} 4 cm) and T3 through neoadjuvant chemotherapy, quadrantectomy and high dose rate brachytherapy as a boost, complementary radiotherapy and adjuvant chemotherapy, considering local control and overall survival. Material and method: this clinical prospective descriptive study was based on the evaluation of 88 patients ranging from 30 to 70 years old, with infiltrating ductal carcinoma, clinical stage IIb and IIIa, responsive to the neoadjuvant chemotherapy, treated from June/1995 to December/2006. Median follow-up was 58 months. Using clinical methods the tumor was evaluated before and after three or four cycles of chemotherapy based on anthracyclines. Overall survival and local control were assessed according to Kaplan-Meier methodology. Results: Local control and overall survival in five years were 90% and 73.5%, respectively. Conclusion: local control and overall survival were comparable to other forms of treatment. (author)

  11. Breast conserving treatment of locally advanced carcinoma T2 and T3 after neoadjuvant chemotherapy followed by quadrantectomy and high dose-rate brachytherapy, as a boost, complementary teletherapy and adjuvant chemotherapy; Tratamento conservador dos carcinomas de mama localmente avancados T2 e T3, apos quimioterapia neoadjuvante, com quadrantectomia e braquiterapia de alta taxa de dose como reforco de dose, teleterapia complementar e quimioterapia adjuvante

    Energy Technology Data Exchange (ETDEWEB)

    Fristachi, Carlos Elias [Instituto do Cancer Dr. Arnaldo Vieira de Carvalho (ICAVC), Sao Paulo, SP (Brazil). Servico de Onco-Ginecologia e Mastologia]. E-mail: cefristachi@uol.com.br; Miziara Filho, Miguel Abrao; Soares, Celia Regina; Fogaroli, Ricardo Cesar; Pelosi, Edilson Lopes; Martins, Homero Lavieri Martins [Instituto do Cancer Dr. Arnaldo Vieira de Carvalho (ICAVC), Sao Paulo, SP (Brazil). Servico de Radioterapia; Baracat, Fausto Farah [Hospital do Servidor Publico Estadual de Sao Paulo (HSPE), SP (Brazil). Servico de Ginecologia e Mastologia; Piato, Sebastiao [Irmandade da Santa Casa de Misericordia de Sao Paulo, SP (Brazil). Dept. de Obstetricia e Ginecologia (DOGI)

    2005-07-01

    Objective: to assess the treatment of breast cancer T2 and T3(T > = 4 cm), through neoadjuvant chemotherapy, quadrantectomy and high-dose-rate (HDR) brachytherapy as a boost, complementary radiotherapy and adjuvant chemotherapy, considering its method problems, its esthetics results, the aspect of local control, overall survival, and disease-free survival. Patients and method: this clinical prospective descriptive study was based on the evaluation of 26 patients ranging from 30 to 70 years old, with infiltrating ductal carcinoma, clinical stage IIB and IIIA, responsive to the neoadjuvant chemotherapy. Early and late radiotherapy complications were evaluated according to the criteria established by the RTOG/EORTC (Radiotherapy and Oncology Group /European Organization for Research and Treatment of Cancer) groups. Esthetics evaluation was done in accordance with the criteria set by a plastic surgeon. Local control was evaluated by clinical method, mammography and ultrasonography. Overall survival (OS) and the disease-free survival (DFS) were assessed according to Kaplan-Meier methodology. All the patients were treated at the Dr. Arnaldo Vieira de Carvalho Cancer Institute, from June/1995 to November/2001, and evaluated in March, 2002, with median follow-up of 28.7 months. Results: early complications were observed in 8 patients (30.6%). Two patients were classified as G3 and G4 (RTOG/EORTC). Six patients had late complications and three of them (11.5%) were classified as G3 and G4. One patient (3.8%) had local recurrence, 64 months after having local treatment. Esthetics results were considered good or regular in 16 patients (60.5%) out of 24 patients who were examined. Overall survival and disease-free survival in 24, 36 and 60 months were 100%, 92.3% and 83.1% respectively. Conclusion: early and late radiotherapy complications were considerate high when compared to literature, but esthetic results were considered acceptable. RL, OS and DFS were comparable to other forms of treatment. (author)

  12. New findings for the use of NMR- and computer tomography for gauging the potential of drilling fluids to cause damage to rocks; Neue Erkenntnisse bei der Anwendung von NMR- und Computertomografie-Methoden im Rahmen der Bewertung des Traegerschaedigungspotentiales von Bohrfluessigkeiten

    Energy Technology Data Exchange (ETDEWEB)

    Zwaag, C. van der [Reservoir Labs. AS, Trondheim (Norway); Stallmach, F. [Univ. Leipzig (Germany). Fakultaet fuer Physik und Geowissenschaften; Hanssen, J.E. [MI/Anchor Drilling Fluids AS, Stavanger (Norway); Soergaard, E. [Norsk Hydro AS, Bergen (Norway); Toennesen, R. [Saga Petroleum ASA, Stavanger (Norway)

    1998-12-31

    Polyanionic cellulose, xanthane and ppolyglycole are standard additives for water-based drilling fluids. These are added to drilling liquids to control water loss, provide viscosity and inhibit slating. Filtration losses, which are unavoidable when drilling, cause scavenging polymers to penetrate the area around the drilled hole. This causes a number of different reactions with the surrounding rocks and may ultimately have a permanent influence on the flow conditions of hydrocarbons. The study mentioned above aimed at determining the damage potential of these additives. [Deutsch] Polyanionische Cellulose, Xanthan und Polyglykol sind uebliche Zusatzstoffe von wasserbasischen Bohrspuelungen. Diese werden Bohrfluessigkeiten zur Wasserverlustkontrolle, zur Viskositaetsbildung und zur Schieferinhibierung zugesetzt. Die beim Bohrprozess unvermeidlichen Filtrationsverluste fuehren dazu, dass Spuelungspolymere beim Bohren in den Bohrlochnahbereich eindringen. Die Beschaffenheit dieser Stoffe fuehrt nach dem Eindringen zu unterschiedlichen Reaktionen mit dem Traegergestein. Diese koennen letzten Endes einen dauerhaften Einfluss auf die Zuflussbedingungen von Kohlenwasserstoffen haben. Das Ziel der vorliegenden Studie war es, das Traegerschaedigungspotential der obengenannten Spuelungszusaetze zu charakterisieren. (orig.)

  13. Combined application of numerical simulation models and fission tracks analysis in order to determine the history of temperature, subsidence and lifting of sedimentary basins. A case study from the Ruhr Coal basin inWest Germany; Die kombinierte Anwendung numerischer Simulationsmodelle und Spaltspurenuntersuchungen zur Entschluesselung der Temperatur-, Subsidenz- und Hebungsgeschichte von Sedimentbecken - Ein Fallbeispiel aus dem Ruhrkohlenbecken Westdeutschlands

    Energy Technology Data Exchange (ETDEWEB)

    Karg, H. [Forschungszentrum Juelich (Germany). Inst. fuer Erdoel und organische Geochemie; Littke, R. [RWTH Aachen (Germany); Bueker, C. [Univ. Bern (Switzerland). Inst. fuer Geologie

    1998-12-31

    The Ruhr Coal basin is one of the globally best known sedimentary basins. According to classical, established the Ruhr Basin is a typical foreland molasse basins. The thermal history (heating and cooling) and the structural and sedimentary development since the formation of the basin, i.e. subsidence and lifting and erosion are of the first importance for the potential formation of hydrocarbons. In order to quantify these processes, two-dimensional numerical simulation models (based on geological and seismological sections) of the Ruhr basin were developed from which one could conclude the heat flow at the time of maximum basin depth after variscis orogenesis, maximum temperatures of individual strata sections and thickness of eroded strata. The PetroMod program package of the company IES/Juelich was used for these analyses. Finite-element-grids enable mathematican mapping and reconstruction of complex geological structures and processes. The models on temperature history are calibrated by comparing measured and calculated carbonification (vitrinite reflection) data. (orig./MSK). [Deutsch] Das Ruhrkohlenbecken stellt weltweit eines der am besten erforschten Sedimentbecken dar. Nach klassischen und etablierten Beckenmodellen kann das Ruhrbecken als typisches Vorlandmolassebecken angesehen werden. Besonders relevant fuer die potentielle Bildung von Kohlenwasserstoffen sind in erster Linie die thermische Geschichte (Aufheizung und Abkuehlung) sowie die strukturelle und sedimentaere Entwicklung seit der Beckenbildung, sprich Versenkungs-, Hebungs- und Erosionsprozesse. Um solche Prozesse zu quantifizieren, wurden im Ruhrbecken zweidimensionale (d.h. auf der Grundlage von geologischen und seismischen Sektionen) numerische Simulationsmodelle entwickelt, die Aufschluss ueber Waermefluesse zur Zeit der maximalen Beckeneintiefung im Anschluss an die variszische Orogenese, erreichte Maximaltemperaturen einzelner Schichtglieder sowie die Maechtigkeit erodierter Schichten im Becken liefern. Hierzu wurde das Programmpaket PetroMod der Firma IES/Juelich verwendet. Auf der Basis von Finite-Element-Netzen koennen komplexe geologische Strukturen und Ablaeufe mathematisch erfasst und rekonstruiert werden. Die Kalibration entwickelter Modelle zur Temperaturgeschichte wird durch den Vergleich gemessener mit berechneten Inkohlungsdaten (Vitrinitreflexion) durchgefuehrt. (orig./MSK)

  14. Synthesis and characterisation of SiC{sub f}/Cu matrix composites and their application in a divertor flat-tile mock-up; Synthese und Charakterisierung von SiC{sub f}/Cu-Matrix-Verbundwerkstoffen und ihre Anwendung in einem Modell einer Divertor-Komponente

    Energy Technology Data Exchange (ETDEWEB)

    Paffenholz, Verena

    2010-06-30

    In future fusion reactors materials are operating under extreme conditions. The fusion plasma leads to heat fluxes to the plasma facing materials (PFM) of 15-20 MW/m{sup 2} in the divertor region. To increase the thermal efficiency of future fusion power plants like DEMO, a higher coolant temperature of 300 C compared to 150 C at ITER is necessary which leads to an increased temperature of 550 C at the interface between tungsten as PFM and CuCrZr as heat sink material. This will cause high stresses as a result of the temperature gradient and the different coefficients of thermal expansion (CTE). Due to insufficient mechanical properties of the precipitation-hardened CuCrZr at this temperature, SiC{sub f}/Cu composites are considered to strengthen the critical zone with an interlayer between the PFM and the heat sink, as they combine high mechanical strength and a good thermal conductivity. The aim of this investigation is the preparation and mechanical as well as thermal characterisation (in particular the mechanical strength and thermal conductivity) of SiC{sub f}/Cu composites, and in addition, the manufacture of a metal matrix composite (MMC), as well as the assembly of a flat-tile mock-up to investigate the performance of an MMC interlayer under heat loads. A new method was developed to synthesise an appropriate MMC for the flat-tile mock-up and in addition to enable the measurement of the thermal conductivity perpendicular to fibre direction. Unidirectional (UD) layers were prepared by two subsequent electroplating processes which allow adjusting various fibre volume fractions. The UD layers were stacked with different fibre orientations (0 /0 , 0 /90 ) and consolidated by vacuum hot pressing to form a multilayer MMC. In addition, MMC specimens were prepared by hot isostatic pressing (HIP) in order to measure the mechanical properties. To improve the bonding between fibre and matrix, the fibres were coated with thin titanium (SCS6) and Ti-TaC (SCS0) interlayers. Tensile tests of MMC specimens gave information about the tensile strength at different temperatures. A higher fibre volume fraction leads to an increased tensile strength, whereas higher temperatures reduce the tensile strength. The required tensile strength of 300 MPa was obtained with a fibre volume fraction of ∝10%. At temperatures above ∝300 C tensile tests, thermo mechanical fatigue tests, and the determination of the CTE showed an increased ductility of Cu. Contrary to tensile tests at room temperature - the weak point is the layered structure of the fibre - the failure occurred at the interface between fibre and matrix at temperatures of 550 C. Thermal investigations showed the dependence of the thermal diffusivity and thermal conductivity on the fibre volume fraction, the fibre arrangement, and the fibre distance. Narrow fibre distances as well as pores and cracks due to oxide layers within the MMC, will cause thermal barriers and reduce the heat transport. High consolidation temperatures (800 C) lead to a more uniform fibre arrangement and an increased thermal conductivity. However, a high pressure at high temperatures during consolidation can cause fibre rupture, in particular for the 0 /90 fibre orientation. MMC interlayers were synthesised at a pressure of ∝40 MPa and a temperature of 650 C to assemble three flat-tile mock-ups for high heat flux tests at the facility GLADIS at IPP. The MMC consisting of 4 and 5 layers, a fibre volume fraction of 14% and a heat conductivity of ∝180 Wm{sup -1}K{sup -1} were loaded with heat loads of 0.2-10.5 MW/m{sup 2} for a duration of 30 s. Additional cyclic tests at 10.5 MW/m{sup 2} for 20 s every minute showed a high potential of SiC{sub f}/Cu up to a temperature of ∝550 C and as heat sink material in future fusion reactors. For metallographic investigations the heat flux tests were stopped after 80 cycles at 10.5 MW/m{sup 2}. Microscopic investigations showed a good bonding, few cracks and no crack propagation within the MMC which indicates a sufficient heat transport. The weak point is the bonding between the components, e.g. the brazing and the boundary area within the MMC at the edge of the mock-up. The highest stresses (residual, during heat load and after cooling) occur at the interface between tungsten and the MMC at the edge of a mock-up. In interaction with an insufficient brazing or small cracks within the MMC, high stresses can lead to distinguish cracks between the components or within the MMC which will result in an insufficient heat transport and to a local failure, followed by a loss of tungsten tiles. Hence, a good bonding between the components and within the copper matrix and the fibre matrix interface is essential for a good performance of the flat-tile mock-up.

  15. Fundamental studies on the switching in liquid nitrogen environment using vacuum switches for application in future high-temperature superconducting medium-voltage power grids; Grundsatzuntersuchungen zum Schalten in Fluessigstickstoff-Umgebung mit Vakuumschaltern zur Anwendung in zukuenftigen Hochtemperatur-Supraleitungs-Mittelspannungsnetzen

    Energy Technology Data Exchange (ETDEWEB)

    Golde, Karsten

    2016-06-24

    By means of superconducting equipment it is possible to reduce the transmission losses in distribution networks while increasing the transmission capacity. As a result even saving a superimposed voltage level would be possible, which can put higher investment costs compared to conventional equipment into perspective. For operation of superconducting systems it is necessary to integrate all equipment in the cooling circuit. This also includes switchgears. Due to cooling with liquid nitrogen, however, only vacuum switching technology comes into question. Thus, the suitability of vacuum switches is investigated in this work. For this purpose the mechanics of the interrupters is considered first. Material investigations and switching experiments at ambient temperature and in liquid nitrogen supply information on potential issues. For this purpose, a special pneumatic construction is designed, which allows tens of thousands of switching cycles. Furthermore, the electrical resistance of the interrupters is considered. Since the contact system consists almost exclusively of copper, a remaining residual resistance and appropriate thermal losses must be considered. Since they have to be cooled back, an appropriate evaluation is given taking environmental parameters into account. The dielectric strength of vacuum interrupters is considered both at ambient temperature as well as directly in liquid nitrogen. For this purpose different contact distances are set at different interrupter types. A distinction is made between internal and external dielectric strength. Conditioning and deconditioning effects are minimized by an appropriate choice of the test circuit. The current chopping and resulting overvoltages are considered to be one of the few drawbacks of vacuum switching technology. Using a practical test circuit the height of chopping current is determined and compared for different temperatures. Due to strong scattering the evaluation is done using statistical methods. At the end the short-circuit current breaking capability is investigated in liquid nitrogen. The specimens are tested in a synthetic test circuit for this purpose, loaded with an increasing current amplitude until it comes to dielectric failures. The summary of the obtained results shows that the use of vacuum switchgears in superconducting networks is possible. The vacuum interrupter performance is basically unaffected by the low temperature, so it could be used for the same ratings under liquid nitrogen as at ambient temperature.

  16. Determination of the potential for utilising combined heat and power and of the target reduction of CO{sub 2} emissions, inclusive of cost analysis (increased use of combined heat and power); Ermittlung der Potenziale fuer die Anwendung der Kraft-Waerme-Kopplung und der erzielbaren Minderung der CO{sub 2}-Emissionen einschliesslich Bewertung der Kosten (Verstaerkte Nutzung der Kraft-Waerme-Kopplung)

    Energy Technology Data Exchange (ETDEWEB)

    Horn, Manfred; Ziesing, Hans-Joachim [Deutsches Inst. fuer Wirtschaftsforschung, Berlin (Germany); Matthes, Felix Christian; Harthan, Ralph [Oeko Institut e.V., Berlin (Germany); Menzler, Gerald [VIK Verband der Industriellen Energie- und Kraftwirtschaft e.V., Essen (Germany)

    2007-07-15

    The report provides a statistical overview of CHP utilisation up to now in Germany, analyses the general economic and political conditions with a view to evaluating the competitiveness of CHP, discusses the effectiveness of the German CHP Act with respect to its contribution to meeting emissions-related goals, analyses the cost-effectiveness of investments in different types of new CHP installations, addresses mid- and longer term potential as well as impediments to the utilisation of CHP installations, presents model simulations of how CHP is expected to develop in the context of economic conditions subject to various general political conditions and makes recommendations with an eye to additional requirements and opportunities to support CHP, against the background of the findings of the analysis. (orig.)

  17. Application of the FTIR system K300 for the emission and immission measurement of atmospheric trace gases and harmful substances in the air: examples of cases and results. Anwendung des FTIR-Systems K300 zur Emissions- und Immissionsmessung atmosphaerischer Spurengase und Luftschadstoffe: Fallbeispiele und Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Eisenmann, T [Kayser-Threde GmbH, Muenchen (Germany); Mosebach, H [Kayser-Threde GmbH, Muenchen (Germany); Bittner, H [Kayser-Threde GmbH, Muenchen (Germany)

    1993-01-01

    The K300 double oscillation interferometer used for the investigations is a Fourier transform infrared (FTIR) spectrometer which, due to its special optical design, is very suitable for high resolution remote sensing emission and immission (long-path monitoring) measurements of harmful substances in the air and atmospheric trace gases, when used in the field. The spectrum of applications extends from the direct measurement of hot chimney waste gases and of engine exhaust gases via the monitoring of industrial plants or waste dumps (diffuse emission) to the immission measurement of sites with heavy traffic. For direct emission measurements, the infrared characteristic radiation of hot waste gases is used; for the measurement of cold diffuse emission or immission, one measures against an artificial infrared source of radiation, which can be erected at a distance of several hundred metres from the equipment (bistatic configuration, socalled long-path monitoring). The results of different applications, which were obtained in the context of various campaigns of measurements, are shown after a short introduction of the system. (orig./BBR)

  18. Use of waste fuels in cement works. Application of the 17th Ordinance for the Protection against Nuisances (BImSchV) to plants for baking cement clinkers; Einsatz von Sonderbrennstoffen in Zementwerken. Anwendung der 17. BlmSchV auf Anlagen zum Brennen von Zementklinker

    Energy Technology Data Exchange (ETDEWEB)

    Mair, K. [Bayerisches Landesamt fuer Umweltschutz, Muenchen (Germany)

    1995-06-01

    In cement works, other fuels besides the regular ones - coal, heavy fuel and natural gas - are used. Burning these materials requires proper handling and must correspond to state-of-the-art practices, especially as regards clean air measures. The ordinance on fire-places for wastes and other fuel materials (17th ordinance for the protection against nuisances) contains not only relevant emission limits but makes also stipulations as to the design of fire-places, emission monitoring, and general rules. (orig.) [Deutsch] In der Zementindustrie werden neben den sogenannten Regelbrennstoffen wie Kohle, Heizoel S und Erdgas auch Sonderbrennstoffe eingesetzt. Der Einsatz dieser Stoffe setzt jedoch eine ordnungsgemaesse Handhabung bei gleichzeitiger Einhaltung der dem Stand der Technik entsprechenden Massnahmen, besonders zur Luftreinhaltung, voraus. In der Verordnung ueber Verbrennungsanlagen fuer Abfaelle und aehnliche brennbare Stoffe (17. BlmSchV) werden hierzu neben den Emissionsbegrenzungen auch Anforderungen an die Beschaffenheit der Feuerungen, die Emissionsueberwachung sowie allgemeine Regelungen vorgegeben. (orig.)

  19. Application of fast spin-echo T[sub 2]-weighted imaging for examination of the neurocranium. Comparison with the conventional T[sub 2]-weighted spin-echo sequence. Die Anwendung der T[sub 2]-gewichteten Turbo-Spin-Echo-Sequenz zur Untersuchung des Neurokraniums. Vergleich mit der konventionellen T[sub 2]-gewichteten Spin-Echo-Sequenz

    Energy Technology Data Exchange (ETDEWEB)

    Siewert, C. (Strahlenklinik und Poliklinik, Universitaets-Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany)); Hosten, N. (Strahlenklinik und Poliklinik, Universitaets-Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany)); Felix, R. (Strahlenklinik und Poliklinik, Universitaets-Klinikum Rudolf Virchow, Standort Wedding, Freie Univ. Berlin (Germany))

    1994-07-01

    T[sub 2]-weighted spin-echo imaging is the standard screening procedure in MR imaging of the neutrocranium. We evaluated fast spin-echo T[sub 2]-weighted imaging (TT[sub 2]) of the neurocranium in comparison to conventional spin-echo T[sub 2]-weighted imaging (T[sub 2]). Signal-to-noise and contrast-to-noise ratio of normal brain tissues (basal ganglia, grey and white matter, CSF fluid) and different pathologies were calculated. Signal-to-noise ratio and contrast-to-noise ratio were significantly higher than TT[sub 2] than in T[sub 2] (with the exception of grey-to-white matter contrast). Tissues with increased content of water protons (mobile protons) showed the highest contrast to surrounding tissues. The increased signal intensity of fat must be given due attention in fatty lesions. Because the contrast-to-noise ratio between white matter and basal ganglia is less in TT[sub 2], Parkinson patients have to be examined by conventional T[sub 2]. If these limitations are taken into account, fast spin-echo T[sub 2]-weighted imaging is well appropriate for MR imaging of the neurocranium, resulting in heavy T[sub 2]-weighting achieved in a short acquisition time. (orig.)

  20. Intersectorial mobility as a kind of knowledge transfer between research and application. progress and motives of ''side changers''; Intersektorale Mobilitaet als Form des Wissenstransfers zwischen Forschung und Anwendung. Verlaeufe und Motive von ''Seitenwechseln''

    Energy Technology Data Exchange (ETDEWEB)

    Beckert, B.; Buehrer, S.; Lindner, R.

    2008-07-01

    The migration of scientists between public and privately funded research is generally regarded as a boon for innovation. Germany's research landscape however offers little encouragement to this end compared with other countries. Why is it that German scientists evidently switch between universities, extra-university research institutions and corporate research less often? What motives and concomitant conditions are responsible for this? What impact does switching between sectors have for the individual scientist? In an attempt to answer these questions this book presents the results of an extensive survey covering the career path of 178 scientists who were willing to switch. It pinpoints the implications for science policy that can be inferred from the identified promotive and inhibitory factors of professional mobility. The interdisciplinary research groups of the Fraunhofer Institute for Systems and Innovation Research focus on the areas of energy, environment, production, communication, biotechnology, as well as regional research and innovation policy.

  1. Die Auswahl Der Richtigen E-Commerce-Software Für Das Eigene Unternehmen - Anwendung Des AHP-Modells(Şirketiniz İçin Doğru E-Ticaret Yazılım Seçimi – AHP-Model Uygulaması

    Directory of Open Access Journals (Sweden)

    Kemal YAMAN

    2012-01-01

    Full Text Available Die Auswahl der richtigen eBusiness-Software-Lösung hat für das eBusiness-Geschäft von Unternehmen eine große Bedeutung. Das bedeutet, dass die Unternehmen eines kompetentes, effizientes, flexibles und starkes Softwarepakets bedürfen. Dafür müssen sie eine ausführliche Analyse des passenden Softwarepaketes aus dem wirtschaftlichen Aspekt ausführen. Denn eine solche Softwarelösung soll einem Unternehmen ermöglichen, ihre Produkte und Dienstleistungen problemlos online anbieten zu können. Es wird festgestellt, dass sie Auswahl solcher Softwarepakete sorgfältig durchgeführt werden müssen, da diese unterschiedliche Stärken bzw. Eigenschaften aufweisen. Zum Beispiel hat eine Lösung sehr gute Marketing-Tools, die andere jedoch Sicherheits- oder Flexibilität-Tools. Im ersten Teil der Arbeit wird auf die Bedeutung der Auswahl einer eBusiness-Lösung eingegangen und es werden dabei die relevanten Eigenschaften von Softwarelösungen sowie ihre Relevanz für den Unternehmensgeschäftserfolg geschildert. Im zweiten Teil wird der Analytic Hierarchy Process dargestellt, bei dem das Entscheidungsproblem in kleinere Teilaufgaben aufgelöst werden, die dann zu lösen sind. Schließlich werden im dritten Teil in einer abschließenden Zusammenfassung die Ergebnisse und die Schlussfolgerungen geschildert.

  2. Investigation of the epitaxial growth of Pb(Zr{sub 0,52}Ti{sub 0,48})O{sub 3} thin films and their application in ferroelectric superconducting field effect transistors; Untersuchung des epitaktischen Wachstums duenner Pb(Zr{sub 0,52}Ti{sub 0,48})O{sub 3}-Schichten und ihre Anwendung in ferroelektrischen supraleitenden Feldeffektransistoren

    Energy Technology Data Exchange (ETDEWEB)

    Aidam, R

    1999-02-01

    The influences of the polarization of ferroelectric Pb(Zr{sub 0.52}Ti{sub 0.48})O{sub 3} (PZT) films on the properties of YBa{sub 2}Cu{sub 3}O{sub x} (YBCO) films were investigated in ferroelectric superconducting field effect transistors (FSuFETs). First the epitaxial growth of PZT films deposited by reactive sputtering in an argon/oxygen atmosphere was investigated. SrTiO{sub 3} single crystals and YBCO thin films proved as suitable substrates. The lead content of the PZT films depended sensitively on the deposition temperature T{sub s} and the gas pressure. By using a high pressure of 0.26 mbar the correct stoichiometry could be achieved up to an maximum T{sub s} of 580 C. Above a minimum T{sub s} of 540 C the ferroelectric perovskite structure grew. In the optimum temperature range between 560 C and 580 C the films grew with a minimum mosaic spread of {delta}{omega} < 0.3 and a small amount of less than 1% of paraelectric phase. The best ferroelectric properties could be obtained for films with the highest degree of epitaxy and the correct stoichiometry. The maximum remanent polarization amounted P{sub r} = 61 {mu}C/cm{sup 2} and the coercive field E{sub C} was 150 kV/cm at 77 K. The breakdown field was four to five times larger than E{sub C}. Fatigue studies revealed a loss of switchable polarization of 30% after 10{sup 8} cycles at 77 K, whereas loss of retention and the effect of ageing were negligible. During the process of oxidation of the heterostructure at 400 C and an oxygen pressure of 800 mbar a reaction at the PZT/YBCO interface was observed, which lead to a degradation of the transport properties of the superconductor. This reaction could be avoided by a thin SrTiO{sub 3} buffer layer without disturbing the ferroelectric hysteresis essentially.

  3. Establishment and use of a combined test system for assessing the toxicity of environmentally relevant pollutants in soil.- Optimization of keeping conditions in the laboratory and bionomic investigations. Final report; Etablierung und Anwendung eines kombinierten Testsystems zur Beurteilung der Toxizitaet umweltrelevanter Schadstoffe in Boeden. Optimierung der Laborhaltung und bionomische Untersuchungen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Dunger, W.; Mattern, D.; Reise, H.; Schulz, H.J.; Barth, V.; Roemer, M.; Voigtlaender, K.; Zimdars, B.

    1997-12-31

    In order to establish how organisms can be kept with low stress or free of stress in the laboratory, test species from the Oberlausitz region were chosen. The species belong to the groups of soil-living organisms Collembola, Isopoda, and Gastropoda. Keeping results may be considered as confirmed and as suitable for stress investigations. Successful optimization of keeping is only possible for a single species in each case (generalists excepted).- As applicable vital parameters both to confirm keeping success and to assess the impact of sublethal doses of stressors (heavy metals, insecticides), the following were established (in this order of sequence): reproductive success, growth (change of biomass, sloughing), mortality and, with restrictions, activity (running and foraging activity).- As expected, the effect of the heavy metals used was found to depend on their concentration. Increased mortality as a rule was only found in the wake of cadmium contaminations; reduced growth and, especially, reduced reproduction was triggered also by lead and zinc contaminations. With this regard, subtle differentiations were established. Use of Lindan in the specified dosage proved to have almost no impact during the (short) test period. (orig./MG)

  4. A method for the evaluation of a system for the disposal and use of biogenic wastes and farm manure; Vorstudie fuer eine Methode zur Bewertung der Entsorgungs- und Nutzungsverfahren von biogenen Abfaellen und Hofduenger. Entwicklung der Methodik und Anwendung auf ausgewaehlte Technologien

    Energy Technology Data Exchange (ETDEWEB)

    Baettig, M.; Klingler, G.; Dettli, R. [econcept AG, Zuerich (Switzerland); Frischknecht, R.; Tuchschmid, M. [ESU-Services Ltd., fair consulting in sustainability, Uster (Switzerland)

    2009-06-15

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) deals with the evaluation of a system for the disposal and use of biogenic wastes and farm dung. The principle aim of the study was to develop a method for the evaluation of the various methods for the disposal and use of biogenic wastes and the manure produced in agriculture. A further aim was the exemplary use of the method on a selection of waste disposal methods and the drawing of initial conclusions from the ecological, economic and social points of view. The report provides details on the biomass fractions examined and their energy content. The fundamentals on which the development of the methods used are based are described. Test use of the multi-criterion analysis developed is discussed as is sensitivity analysis. Finally conclusions concerning the evaluation are presented and recommendations are made. The appendix to the report contains details on the comprehensive questionnaire used to collect information and the results of an on-line survey on the weighting of the criteria. Also, fact sheets on the 24 disposal and usage variants examined and an overview of disposal and collection costs are presented. The appendix also contains result tables on the use of the method for biogenic wastes, sewage sludge, farm manure, wood wastes and scrap wood.

  5. The implementation of the Solid Waste Management Greenhouse Gas Calculator (SWM GHG Calculator). Assessement of climate-relevant impacts by waste management measures in Turkey; Der Klimarechner Abfallwirtschaft in der praktischen Anwendung. Abschaetzung klimarelevanter Wirkungen durch die Umsetzung abfallwirtschaftlicher Massnahmen in der Tuerkei

    Energy Technology Data Exchange (ETDEWEB)

    Behnsen, Andreas [Fa. Wienecke, Hillebrecht und Partner, Ingenieurgesellschaft fuer Energiemanagement, Wolfenbuettel (Germany); Gesellschaft fuer Stoffstrom- und Abfallmanagement (GAM), Wolfenbuettel (Germany); Hillebrecht, Kai [Fa. Wienecke, Hillebrecht und Partner, Ingenieurgesellschaft fuer Energiemanagement, Wolfenbuettel (Germany); Berger, Sandra; Pino, Maria del; Arpaci, Kevin [Gesellschaft fuer Stoffstrom- und Abfallmanagement (GAM), Wolfenbuettel (Germany)

    2011-01-15

    At the beginning of this year, the introduction of the Solid Waste Management Greenhouse Gas Calculator (SWM GHG Calculator), attracted great interests in the German trade journals. Among others, the KfW development bank and the gtz refer on their web-sites to the excel tool, that enables to calculate the climatic impacts of national, regional and local waste management measures and gives an estimation regarding the costs. The calculator is based on studies of the Oeko-Institut and the ifeu, in which the German situation is described in detail and as an international example, the Turkey is presented. The calculations in this paper are founded on these studies. The estimation of experts from the KfW development bank, that 10 % to 15 % of the greenhouse gas emissions are caused by waste management activities, can be confirmed for Turkey. As executive actors in the field of waste management the municipalities have the possibility to contribute to a considerable extent to comply the targets of the Kyoto protocol. Probably this is the greatest part the state directly can contribute to the CO{sub 2}-Reduction. (orig.)

  6. Effects of chemicals on terrestrial ecosystems exhibiting different types of stability. Pt. 2. Application of fractal geometry to structural analysis in terrestrial ecotoxicology; Auswirkungen von Chemikalien auf terrestrische Oekosysteme unterschiedlichen Stabilitaetstyps. T. 2. Anwendung der fraktalen Geometrie zur Strukturanalyse in der terrestrischen Oekotoxikologie

    Energy Technology Data Exchange (ETDEWEB)

    Bornkamm, R.; Darius, F.

    1995-04-01

    The problem at issue in the present study was whether and how reactions of terrestial ecosystems to anthropogenic xenobiotics can be measured and interpreted. For this pupose test were performed on two types of vegetation which are primarily distinguishable by their reproductive strategies (via seeds and buds, respectively) and also represented by plants of different taxonomic classes. The chemicals used were two low-dosed herbicides (2.4.5-T and atrazine) which elicit responses on several important physiological levels of the plant organism. Strength and duration of responses differed considerably between the two plant systems studied. These observations gave rise to the question as to what can be said on the tested plant systems in general concerning the extent and reversibility of the effects brought about by these interventions. For this purpose the processes assumed to be acting within the biocoeonoces had to be formulated in a model and interpreted. The resultant model permits following the chain of events leading from an individual stress reaction to a complex response of the whole system. It was possible to compare various simulation results with the reactions found in tests on real ecosystems and in other cases to derive from the hypotheses capable of experimental verification. The authors believe that activities in terrestrial ecotoxicology should go beyond the gathering of data from empirical substance testing, which is undoubtedly a necessity for licensing procedures, by furthering basic research. Theoretical considerations make it seem unrealistic to attempt predictions on the future development of any certain ecosystem (whether with or without anthropogenic stress). Statements on the probability of effects, by contrast, to have a certain validty, provided they are based on a sufficient knowledge of type-specific responses of systems and of influences of background conditions. (orig.) [Deutsch] Fuer die Bearbeitung des Problems, ob und wie Reaktionen terrestrischer Oekosysteme auf anthropogene Fremdstoffe messbar und interpretationsfaehig sind, wurden zwei Vegetationstypen getestet, deren Arten sich primaer in ihrer Verbreitungsstrategie (ueber Samen bzw. ueber Knospen) unterscheiden, die hier aber auch von Pflanzen unterschiedlicher Klassen aufgebaut werden. Als Chemikalien wurden zwei niedrig dosierte Herbizide (2.4.5-T und Atrazin) verwendet, die auf vielen wichtigen Ebenen des Pflanzenorganismus Wirkungen ausloesen. Es konnten an Staerke und Dauer ganz unterschiedliche Reaktionen in den beiden Systemen beobachtet werden. Die Frage aufgrund dieser Beobachtungen war, welche generellen Aussagen sich ueber Ausmass und Reversibilitaet dieser Eingriffe bzw. Veraenderungen fuer die getesteten Systeme treffen lassen. Hierzu mussten die vermuteten Vorgaenge innerhalb der Pflanzengemeinschaften in ein Modell gefasst und interpretiert werden. Mit dem vorgestellten Modell ist es moeglich, den Weg von der individuellen Strassenreaktion zur komplexen Systemantwort nachzuverfolgen. Verschiedene Simulationsergebnisse konnten direkt mit Reaktionen getesteter realer Oekosysteme verglichen werden, oder fuehrten zu Hypothesen, die sich experimentell pruefen liessen. Im Bereich der terrestrischen Oekotoxikologie sind u.E. neben den (fuer die laufenden Zulassungsverfahren) notwendigen Datensammlungen aus empirischen Substanzpruefungen auch weitere Grundlagenforschungen wichtig. Denn eine Vorhersage ueber die konkrete Entwicklung eines bestimmten Oekosystems (mit oder ohne anthropogenem `Stess`) scheint auf Grund theoretischer Argumente wenig realistisch, bei ausreichender Kenntnis aber von typbezogenen Systemreaktionen und Einfluss von Randbedingungen koennen immerhin Aussagen ueber die Wahrscheinlichkeit von Effekten erwartet werden. (orig.)

  7. Defining biochemical recurrence after radical prostatectomy and timing of early salvage radiotherapy. Informing the debate

    Energy Technology Data Exchange (ETDEWEB)

    Budaeus, Lars; Schiffmann, Jonas; Graefen, Markus; Huland, Hartwig; Tennstedt, Pierre [University Medical Center Hamburg-Eppendorf, Martini-Clinic, Prostate Cancer Center, Hamburg (Germany); Siegmann, Alessandra; Boehmer, Dirk; Budach, Volker [Charite University Hospital, Department of Radiation Oncology, Berlin (Germany); Bartkowiak, Detlef; Wiegel, Thomas [University Hospital Ulm, Department of Radiation Oncology, Ulm (Germany)

    2017-09-15

    The optimal prostate-specific antigen (PSA) level after radical prostatectomy (RP) for defining biochemical recurrence and initiating salvage radiation therapy (SRT) is still debatable. Whereas adjuvant or extremely early SRT irrespective of PSA progression might be overtreatment for some patients, SRT at PSA >0.2 ng/ml might be undertreatment for others. The current study addresses the optimal timing of radiation therapy after RP. Cohort 1 comprised 293 men with PSA 0.1-0.19 ng/ml after RP. Cohort 2 comprised 198 men with SRT. PSA progression and metastases were assessed in cohort 1. In cohort 2, we compared freedom from progression according to pre-SRT PSA (0.03-0.19 vs. 0.2-0.499 ng/ml). Multivariable Cox regression analyses predicted progression after SRT. In cohort 1, 281 (95.9%) men had further PSA progression ≥0.2 ng/ml and 27 (9.2%) men developed metastases within a median follow-up of 74.3 months. In cohort 2, we recorded improved freedom from progression according to lower pre-SRT PSA (0.03-0.19 vs. 0.2-0.499 ng/ml: 69 vs. 53%; log-rank p = 0.051). Patients with higher pre-SRT PSA ≥0.2 ng/ml were at a higher risk of progression after SRT (hazard ratio: 1.8; p < 0.05). The vast majority of patients with PSA ≥0.1 ng/ml after RP will progress to PSA ≥0.2 ng/ml. Additionally, early administration of SRT at post-RP PSA level <0.2 ng/ml might improve freedom from progression. Consequently, we suggest a PSA threshold of 0.1 ng/ml to define biochemical recurrence after RP. (orig.) [German] Der optimale Wert des prostataspezifischen Antigens (PSA) nach radikaler Prostatektomie (RP) zur Definition eines biochemischen Rezidivs und zur Initiierung einer Salvage-Strahlentherapie (SRT) ist noch immer umstritten. Waehrend eine adjuvante oder extrem fruehe SRT unabhaengig vom PSA-Verlauf fuer einige Patienten eine Uebertherapie bedeuten wuerde, waere eine SRT bei einem PSA >0,2 ng/ml fuer andere eine Untertherapie. In der vorliegenden Studie wird der optimale

  8. The role of computed tomography in evaluation of a white matter edema during postoperative brain radiation therapy; Beobachtung von Oedemen in der weissen Substanz waehrend postoperativer Hirnbestrahlung. Die Rolle computertomographischer Untersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Thalacker, U.; Somogyi, A.; Nemeth, G. [Imre-Haynal-Univ. fuer Gesundheitswissenschaften, Strahlentherapeutischer Lehrstuhl, Budapest (Hungary); Liszka, G. [Staatliches Onkologisches Inst., Roentgendiagnostische Abt., Budapest (Hungary)

    1998-01-01

    ./MG) [Deutsch] Ziel unserer Untersuchungen war es festzustellen, inwieweit man ein waehrend einer postoperativen Hirnbestrahlung aufgetretenes Oedem und dessen Verlauf nach Diuretikagabe mit Hilfe von computertomographisch ermittelten HE-Werten (Houndsfield-Einheiten) verfolgen kann. In der ersten Untersuchungsserie wurden bei 75 Patienten (Alter 20 bis 65 Jahren; Patientegruppe 1) mit Zephalalgie die HE-Werte der nativen unveraenderten weissen Substanz bestimmt. In der zweiten Patientengruppe befanden sich 20 Patienten mit operierten Gehirntumoren bei denen von Strahlentherapie und nach 10, 20, 30, 40 und 50 Gy die HE-Werte bestimmt wurden. In der dritten Patientengruppe befanden sich 64 Patienten, die wegen eines Gehirntumors bereits operiert worden waren und nun einer postoperativen Radiatio unterzogen wurden. In der zweiten und dritten Patientengruppe wurden die Bestrahlungen teils mit Telekobalt, teils mit Photonen eines Linearbeschleunigers (6 und 9 MeV) durchgefuehrt. Bei der CT-Untersuchungen kam ein Siemens Somatom CR (125 kV, 450 mAs) mit einer Scan-Zeit von 5 s zur Anwendung. In der ersten Patientengruppe stellten wir keine Werte unter 30 HE in der weissen Substanz fest. Die Werte der zweiten Patientengruppe bewegten sich ohne Diuretikagabe zu Beginn der Bestrahlung zwischen 25 und 29 HE. Bei einem Abfall unter 25 HE traten Dauerkopfschmerz, Schwindel und Querulanz auf. In diesen Faellen wurde die diuretische Behandlung so lange gesteigert, bis wieder Werte von 25 bis 29 HE vorlagen. In derm18itten Patientengruppe stellten wir zu Beginn der Radiatio bei 47 von 64 Patienten Werte von 25 bis 29 HE fest. Obwohl jedem Patienten von Anfang an Furosemid verabreicht wurde, verringerten sich bei 28 Patienten die Werte auf 20 bis 24 HE. Eine Verbesserung konnte mit zusaetzlicher Gabe von Glyzerin per os erreicht werden. Daraufhin pendelten sich die Werte auf 25 bis 29 HE ein. Lediglich in einem Fall fielen die Werte unter 20 HE. Hier war eine zusaetzliche Gabe Mannit

  9. A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs

    NARCIS (Netherlands)

    L.A.Th. Hilgers (L. A Th); P.L.I. Platenburg (P. L I); A. Luitjens (A.); B. Groenveld (B.); T. Dazelle (T.); J.T.M. Weststrate

    1994-01-01

    textabstractThe adjuvanticity of a sulfolipopolysaccharide (SLP) incorporated into a squalane-in-water emulsion (SLP/S/W) was compared with that of a mineral oil-in-water (O/W) adjuvant currently used in commercial porcine vaccines. Groups of pigs were immunized twice with vaccines comprising either

  10. Lehrbuch Guided Imagery in Music (GIM)

    DEFF Research Database (Denmark)

    Maack, Carola; Geiger, Edith Maria

    Guided Imagery in Music (GIM) ist eine musikpsychotherapeutische Methode, bei welcher der Patient eine Auswahl meist klassischer Musik in einem entspannten Zustand hört und sein Erleben (= Imaginationen) der Therapeutin mitteilt. Theoretische Hintergründe, klinische Anwendung, sowie methodenspezi......Guided Imagery in Music (GIM) ist eine musikpsychotherapeutische Methode, bei welcher der Patient eine Auswahl meist klassischer Musik in einem entspannten Zustand hört und sein Erleben (= Imaginationen) der Therapeutin mitteilt. Theoretische Hintergründe, klinische Anwendung, sowie...

  11. Composting of biological waste. Processes and utilisation; Bioabfallkompostierung. Verfahren und Verwertung

    Energy Technology Data Exchange (ETDEWEB)

    Gronauer, A.; Claassen, N.; Ebertseder, T.; Fischer, P.; Gutser, R.; Helm, M.; Popp, L.; Schoen, H.

    1997-12-31

    The project investigated environmentally compatible concepts for procesing and utilisation of biological waste by means of composting and spreading on agricultural and gardening plots. The project comprised three parts: Composting techniques, applications of compost in agriculture and gardening, and applications in landscaping. This volume comprises all three reports. (orig./SR) [Deutsch] Die umweltschonende Aufbereitung und Verwertung von Bioabfall durch Kompostierung und Rueckfuehrung auf landwirtschaftliche und gaertnerische Flaechen wurde untersucht. Dieses Projekt war dreigeteilt in die Bereiche der Kompostierung selbst, der Anwendung des Komposts in der Landwirtschaft und seiner Anwendung im Gartenbau sowie im Garten- und Landschaftsbau (GaLa-Bau). Die vorliegende Schrift enthaelt die genannten drei Teilberichte. (orig./SR)

  12. Radical radiotherapy for T3 laryngeal cancers

    Energy Technology Data Exchange (ETDEWEB)

    Uno, T. [International Medical Center of Japan, Tokyo (Japan). Dept. of Radiation Therapy; Itami, J. [International Medical Center of Japan, Tokyo (Japan). Dept. of Radiation Therapy; Kotaka, K. [International Medical Center of Japan, Tokyo (Japan). Dept. of Radiation Therapy; Toriyama, M. [International Medical Center of Japan, Tokyo (Japan). Dept. of Otolaryngology

    1996-08-01

    From 1974 through 1992, 37 previously untreated patients with T3 laryngeal cancer (supraglottic 15, glottic 22) were treated with initial radical radiotherapy and surgery for salvage. Two-year local control rate with radiotherapy alone, ultimate voice preservation rate, and ultimate local control rate for T3 supraglottic cancer were 33%, 33%, and 60%, respectively. Corresponding figures for T3 glottic cancer were 32%, 23%, and 77%, respecitvely. Five-year cause-specific survival rate for T3 supraglottic cancer and glottic cancer were 47% and 77%, respectively. In T3 supraglottic cancer, none of the 4 patients with subglottic tumor extension attained local control by radiotherapy alone, and local-regional recurrence-free time were significantly shorter in patients with subglottic tumor extension or tracheostomy before radiotherapy. There were no serious late complications such as chondronecrosis, rupture of carotid artery attributed to radical radiotherapy, while 3 patients had severe laryngeal edema requiring total laryngectomy. (orig.) [Deutsch] Von 1974 bis 1992 wurden 37 zuvor nicht behandelte Patienten mit T3-Larynxkarzinomen (15 supraglottisch, 22 glottisch) primaer kurativ bestrahlt und, wenn erforderlich, einer Salvage-Operation unterzogen. Die Zwei-Jahres-Kontrollrate bei alleiniger Strahlentherapie, die Rate der Stimmerhaltung sowie die unter Einschluss der Operation erreichbare lokale Kontrollrate bei supraglottischen T3-Larynxkarzinomen betrugen 33%, 33% und 60%. Bei glottischen T3-Karzinomen wurden jeweils 32%, 23% und 77% erreicht. Die Fuenf-Jahres-Ueberlebensrate betrug 47% bei supraglottischen T3-Karzinomen und 77% bei den glottischen Karzinomen. Im Fall von supraglottischen Karzinomen erreichte keiner der vier Patienten mit subglottischer Tumorausdehnung eine lokale Kontrolle durch alleinige Strahlentherapie. Die lokoregionale rezidivfreie Zeit war bei den Patienten mit subglottischer Tumorausdehnung oder Tracheostomie vor Einleitung der

  13. Radiotherapeutic concepts in cancer of unknown primary site; Strahlentherapeutische Konzepte beim CUP-Syndrom

    Energy Technology Data Exchange (ETDEWEB)

    Krug, D.; Debus, J.; Sterzing, F. [Universitaetsklinikum Heidelberg, Klinik fuer Radioonkologie und Strahlentherapie, Heidelberg (Germany)

    2014-02-15

    The term cancer of unknown primary (CUP) encompasses a group of entities which differ to a great extent regarding etiology, prognosis and therapeutic management. The aim of the study was an elaboration of the role of radiotherapy in CUP syndrome. Systematic literature search and specification of the available treatment options. Radiotherapy is an integral part of interdisciplinary management approaches for patients with CUP in both curative and palliative situations. Radio-oncological techniques, such as intensity-modulated radiotherapy and stereotactic body radiotherapy increase the therapeutic window. Modern diagnostic modalities from radiology and nuclear medicine are the cornerstone of radiotherapeutic interventions, especially in terms of target volume definition and pretherapeutic staging. In the interdisciplinary setting radiation oncology offers the possibility of curative and often organ preserving approaches in patients with axillary and cervical CUP. In addition, improvement and preservation of quality of life can be achieved in patients with metastatic disease. Radiation oncology is a crucial component of the interdisciplinary management of patients with CUP. Therapeutic decisions in patients with CUP should be made in an interdisciplinary setting. (orig.) [German] Das Cancer-of-unknown-primary(CUP)-Syndrom fasst eine Gruppe von Erkrankungen zusammen, die durch eine ausgepraegte Heterogenitaet hinsichtlich Aetiologie, Therapie und Prognose gepraegt sind. Darstellung der Rolle der Strahlentherapie beim CUP-Syndrom. Systematische Literaturrecherche und Erlaeuterung der Behandlungsoptionen. Die Strahlentherapie ist beim CUP-Syndrom sowohl in adjuvanten und definitiven Therapiekonzepten wie auch in palliativer Intention etabliert. Technisch innovative Verfahren wie die intensitaetsmodulierte Radiotherapie und die stereotaktische Bestrahlung im Koerperstammbereich ermoeglichen eine Vergroesserung der therapeutischen Breite. Eine leistungsfaehige und moderne

  14. WASA-BOSS. Development and application of Severe Accident Codes. Evaluation and optimization of accident management measures. Subproject E. Improvement of the lower head model in MELCOR and calculations in connection with the FUKUSHIMA accident. Final report; WASA-BOSS. Weiterentwicklung und Anwendung von Severe Accident Codes. Bewertung und Optimierung von Stoerfallmassnahmen. Teilprojekt E. Verbesserung des Lower Head-Modelles fuer MELCOR und MELCOR-Rechnungen zu Fukushima. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Kretzschmar, Frank; Dietrich, Philipp; Gabriel, Stephan; Miassoedov, Alexei

    2016-12-15

    The knowledge of the key phenomena, which govern the chronological sequence of a core melt accident, is a crucial precondition for the development of SAMGs (Severe Management Guides) to avoid and mitigate the radiological consequences for the population and the environment. In the frame of a dissertation a new model has been coupled with MELCOR, which describes the thermal interaction of a core melt with the RPV (reactor pressure vessel) wall in the lower plenum. This model allows a better description of this phenomenon. The method to couple extern programs with MELCOR had been already developed and used in a former dissertation at KIT-IKET. The model has been validated recalculating according experiments in the LIVE facility. Afterwards a defined accident scenario has been calculated for a German generic KONVOI power plant. 12 months after the start of the project a MELCOR input has been developed using data delivered by the Ruhr university of Bochum (subproject ''Simulation des Unfalls in Fukushima-Daichi zur Bewertung des Stoerfall-Analysecodes ATHLET-CD''). The results of this simulation have made a contribution to review the current understanding of the FUKUSHIMA sequence. HZDR and KIT-IKET have agreed in the course of the project, that KIT-IKET will develop a MELCOR input of a german generic KONVOI power plant following an ATHLET-CDinput of HZDR. Using this MELCOR input, a comparative analysis has been performed.

  15. WASA-BOSS. Development and application of Severe Accident Codes. Evaluation and optimization of accident management measures. Subproject F. Contributions to code validation using BWR data and to evaluation and optimization of accident management measures. Final report; WASA-BOSS. Weiterentwicklung und Anwendung von Severe Accident Codes. Bewertung und Optimierung von Stoerfallmassnahmen. Teilprojekt F. Beitraege zur Codevalidierung anhand von SWR-Daten und zur Bewertung und Optimierung von Stoerfallmassnahmen. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Di Marcello, Valentino; Imke, Uwe; Sanchez Espinoza, Victor

    2016-09-15

    The exact knowledge of the transient course of events and of the dominating processes during a severe accident in a nuclear power station is a mandatory requirement to elaborate strategies and measures to minimize the radiological consequences of core melt. Two typical experiments using boiling water reactor assemblies were modelled and simulated with the severe accident simulation code ATHLET-CD. The experiments are related to the early phase of core degradation in a boiling water reactor. The results reproduce the thermal behavior and the hydrogen production due to oxidation inside the bundle until relocation of material by melting. During flooding of the overheated assembly temperatures and hydrogen oxidation are under estimated. The deviations from the experimental results can be explained by the missing model to simulate bore carbide oxidation of the control rods. On basis of a hypothetical loss of coolant accident in a typical German boiling water reactor the effectivity of flooding the partial degraded core is investigated. This measure of mitigation is efficient and prevents failure of the reactor pressure vessel if it starts before molten material is relocated into the lower plenum. Considerable amount of hydrogen is produced by oxidation of the metallic components.

  16. Joint research project WASA-BOSS: Further development and application of severe accident codes. Assessment and optimization of accident management measures. Project B: Accident analyses for pressurized water reactors with the application of the ATHLET-CD code; Verbundprojekt WASA-BOSS: Weiterentwicklung und Anwendung von Severe Accident Codes. Bewertung und Optimierung von Stoerfallmassnahmen. Teilprojekt B: Druckwasserreaktor-Stoerfallanalysen unter Verwendung des Severe-Accident-Codes ATHLET-CD

    Energy Technology Data Exchange (ETDEWEB)

    Jobst, Matthias; Kliem, Soeren; Kozmenkov, Yaroslav; Wilhelm, Polina

    2017-02-15

    Within the framework of the project an ATHLET-CD input deck for a generic German PWR of type KONVOI has been created. This input deck was applied to the simulation of severe accidents from the accident categories station blackout (SBO) and small-break loss-of-coolant accidents (SBLOCA). The complete accident transient from initial event at full power until the damage of reactor pressure vessel (RPV) is covered and all relevant severe accident phenomena are modelled: start of core heat up, fission product release, melting of fuel and absorber material, oxidation and release of hydrogen, relocation of molten material inside the core, relocation to the lower plenum, damage and failure of the RPV. The model has been applied to the analysis of preventive and mitigative accident management measures for SBO and SBLOCA transients. Therefore, the measures primary side depressurization (PSD), injection to the primary circuit by mobile pumps and for SBLOCA the delayed injection by the cold leg hydro-accumulators have been investigated and the assumptions and start criteria of these measures have been varied. The time evolutions of the transients and time margins for the initiation of additional measures have been assessed. An uncertainty and sensitivity study has been performed for the early phase of one SBO scenario with PSD (until the start of core melt). In addition to that, a code -to-code comparison between ATHLET-CD and the severe accident code MELCOR has been carried out.

  17. Numerical analysis of the bearing capacity of complex rock mechanical underground systems with filigree structures in the presence of imponderables. A contribution to the systematization of the investigative process with application/demonstration using the example of the salt cavern ASSE II/south flank; Numerische Analyse des Tragverhaltens komplexer gebirgsmechanischer untertaegiger Systeme mit filigranen Strukturen bei Anwesenheit von Imponderabilien. Ein Beitrag zur Systematisierung des Untersuchungsprozesses mit Anwendung/Demonstration am Beispiel des Salzbergwerks Schacht ASSE II/Suedflanke

    Energy Technology Data Exchange (ETDEWEB)

    Dyogtyev, Oleksandr

    2017-03-02

    The thesis dealing with the numerical analysis of the bearing capacity of complex rock mechanical underground systems with filigree structures in the presence of imponderables covers the following issues: status of science and technology, concept for the performance of numerical studies on the bearing capacity of large-volume underground systems, application example salt cavern ASSE II - application of the developed concept/development of numerical tools for the overall system/application of the global model to the given questions/realization of the modification potential.

  18. Vorgehensmodelle in Deutschland

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Linssen, Oliver

    2015-01-01

    sich die Anwendung von Vorgehensmodellen über die Zeit entwickelt hat. Die Studie hat gezeigt, dass eine Vielzahl von Vorgehensmodellen im Einsatz ist. Obwohl ein Trend weg von großen Standards zu beobachten ist, werden sowohl agile wie auch klassische Ansätze angewendet. Die Studie zeigt auch, dass...

  19. Neue Indikatoren zur Bestimmung der arithmetischen Regierungskonkordanz

    DEFF Research Database (Denmark)

    Bochsler, Daniel; Sciarini, Pascal

    2006-01-01

    auf proportionalität wird regierungskonkordanz zu einem doppelkopf: einerseits inklusivität andererseits proportionalität INTERESSANT Anwendung auf Hypothese, dass hohe Regierungskonkordanz zu häufigeren Nutzung direktdemokratischer Instrumente führt (///ich hätte es eher andersrum vermutet, aber egal...

  20. Environmental criteria for building site selection; Umweltkriterien bei der Standortsuche fuer Bauvorhaben

    Energy Technology Data Exchange (ETDEWEB)

    Locher, B [Umweltbundesamt, Berlin (Germany)

    1995-09-01

    The author of the present paper provides information on the application of ecological standards as part of the regulation of development planning. (HW) [Deutsch] Die Autorin gibt in ihrem Vortrag Hinweise auf die Anwendung von oekologischen Standards als Regelungsbestandteile fuer die Bauleitplanung. (HW)

  1. Physik gestern und heute: Visualisierung mit der Schlierenmethode

    Science.gov (United States)

    Heering, Peter

    2006-07-01

    Der Name des österreichischen Forschers Ernst Mach ist heute noch mit der Schallgeschwindigkeit verbunden. Diese Auszeichnung resultiert aus Machs Untersuchungen, wie sich Projektile mit Überschallgeschwindigkeit durch die Luft bewegen. Gerade in jüngster Zeit hat die Anwendung derartiger Methoden durch technische Modifikationen wieder einen Aufschwung erfahren.

  2. Methodenangemessene Gütekriterien in der qualitativ-interpretativen Forschung

    OpenAIRE

    Flick, Uwe

    1987-01-01

    Ziele dieses Beitrages sind Darstellung und vergleichende Diskussion verschiedener Strategien zur Absicherung von Daten und Interpretationen bei der Anwendung qualitativ-interpretativer Verfahren: Kodifizierte Vorgehensweisen bei der Interpretation, kommunikative sowie Handlungsvalidierung und schließlich die Triangulation verschiedener Methoden sollen dazu beitragen, qualitative Verfahren und ihre Resultate vom Vorwurf des Spekulativen und Beliebigen zu befreien. Mit dieser Darstellung solle...

  3. TÜV - Zertifizierungen in der Life Science Branche

    Science.gov (United States)

    Schaff, Peter; Gerbl-Rieger, Susanne; Kloth, Sabine; Schübel, Christian; Daxenberger, Andreas; Engler, Claus

    Life Sciences [1] (Lebenswissenschaften) sind ein globales Innovationsfeld mit Anwendungen der Bio- und Medizinwissenschaften, der Pharma-, Chemie-, Kosmetik- und Lebensmittelindustrie. Diese Branche zeichnet sich durch eine stark interdisziplinäre Ausrichtung aus, mit Anwendung wissenschaftlicher Erkenntnisse und Einsatz von Ausgangsstoffen aus der modernen Biologie, Chemie und Humanmedizin sowie gezielter marktwirtschaftlich orientierter Arbeit.

  4. Separate treatment of turbid water from sludge treatment; Separate Behandlung von Truebwaessern aus der Schlammbehandlung

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, B.; Arnold, E.; Wilderer, P.A. [Technische Univ. Muenchen, Garching (Germany). Lehrstuhl und Pruefamt fuer Wasserguete- und Abfallwirtschaft

    1999-07-01

    In semi-technical investigations, discontinuous activated sludge processes and biofilm processes for the nitrification of sludge water were compared. Both processes were found to be equally suited for this application. (orig.) [German] In halbtechnischen Untersuchungen wurden diskontinuierlich betriebene Belebtschlamm- und Biofilmverfahren zur Nitrifikation von Schlammwaessern gegenuebergestellt. Es zeigte sich, dass beide Verfahren gleichermassen fuer diese Anwendung geeignet sind. (orig.)

  5. CpG oligodeoxynucleotides are a potent adjuvant for an inactivated polio vaccine produced from Sabin strains of poliovirus.

    Science.gov (United States)

    Yang, Chunting; Shi, Huiying; Zhou, Jun; Liang, Yanwen; Xu, Honglin

    2009-11-05

    Poliovirus transmission is controlled globally through world-wide use of a live attenuated oral polio vaccine (OPV). However, the imminence of global poliovirus eradication calls for a switch to the inactivated polio vaccine (IPV). Given the limited manufacturing capacity and high cost of IPV, this switch is unlikely in most developing and undeveloped countries. Adjuvantation is an effective strategy for antigen sparing. In this study, we evaluated the adjuvanticity of CpG oligodeoxynucleotides (CpG-ODN) for an experimental IPV produced from Sabin strains of poliovirus. Our results showed that CpG-ODN, alone or in combination with alum, can significantly enhance both the humoral and cellular immune responses to IPV in mice, and, consequently, the antigen dose could be reduced substantially. Therefore, our study suggests that the global use of IPV could be facilitated by using CpG-ODN or other feasible adjuvants.

  6. Mecanismos biopatológicos da metastização ganglionar no carcinoma gástrico. Implicações para a cirurgia radical

    OpenAIRE

    Fradique, António Amável Caldeira

    2009-01-01

    RESUMO A constatação de que o carcinoma gástrico continua a ser a segunda causa de morte por doença oncológica no mundo em geral e em particular em Portugal, assim como a verificação da elevada incidência e letalidade no nosso país, justifica uma particular atenção a esta doença. Apesar de avanços recentes na acção adjuvante e neo-adjuvante de terapêuticas não cirúrgicas, com algumas referências a melhorias na sobrevivência, estas terapêuticas não têm eficácia curativa. Sendo assim, a ...

  7. Case report

    African Journals Online (AJOL)

    raoul

    30 mars 2011 ... Une prise en charge multidisciplinaire basée sur une chirurgie large et une radiothérapie externe adjuvante systématique, est le seul garant d´une bonne évolution voire de la guérison de cette tumeur particulièrement rare et agressive. Conflit d'intérêts. Les auteurs ne déclarent aucun conflit d'intérêts ...

  8. Analysis of the Cross-Reactivity of Various 56 kDa Recombinant Protein Antigens with Serum Samples Collected after Orientia tsutsugamushi Infection by ELISA

    Science.gov (United States)

    2011-01-01

    the cynomolgus monkey model. 37 This vaccine candidate has recently been evaluated for protection against heterolo- gous challenge with five non-Karp...72: 458 – 464 . 34. Kaminski RW , Turbyfill KR , Chao CC , Ching WM , Oaks EV , 2009 . Mucosal Adjuvanticity of a Shigella Invasin...vaccine candidate Kp r56 induces humoral and cellular immune responses in cyno- molgus monkeys . Infect Immun 73: 5039 – 5047 . 38. Shirai A

  9. Cardiac dose-sparing effects of deep-inspiration breath-hold in left breast irradiation. Is IMRT more beneficial than VMAT

    Energy Technology Data Exchange (ETDEWEB)

    Sakka, Mazen; Grabenbauer, Gerhard G. [Coburg Cancer Center, Department of Radiation Oncology, Coburg (Germany); Friedrich-Alexander University of Erlangen-Nuernberg, Faculty of Medicine, Erlangen (Germany); Kunzelmann, Leonie; Metzger, Martin [Coburg Cancer Center, Department of Radiation Oncology, Coburg (Germany)

    2017-10-15

    .01) techniques as compared with FB radiation. There were no significant changes in left lung dose by IMRT; however, with VMAT planning, mean dose to the left lung was reduced by -4% (p = 0.0004). In addition, DIBH significantly increased the mean dose to the contralateral breast with IMRT (+14%, p = 0.002) and significantly reduced the dose to the contralateral breast with VMAT planning (-9%, p = 0.003) compared with the FB position. Additionally, in comparison with VMAT, the IMRT technique reduced mean heart dose both in the FB and the DIBH-position by -30% (p = 0.0004) and -26% (p = 0.002), respectively. Furthermore, IMRT increased the mean dose to the left lung in both the FB and the DIBH position (+5%, p = 0.003, p = 0.006), respectively. There were no significant changes in dose to the right lung and contralateral breast either in the FB or DIBH position between IMRT and VMAT techniques. Left-sided breast irradiation is best performed in the DIBH position, since a considerable dose sparing to the heart and LADCA can be achieved by using either IMRT or VMAT techniques. A significant additional decrease in heart and LADCA dose by IMRT in both FB and DIBH irradiation was seen compared with VMAT. (orig.) [German] Auf der Basis von Metaanalysen, die eine signifikante Verbesserung der Lokalrezidivraten, aber auch des Ueberlebens zeigten, gilt die adjuvante Radiotherapie heute als Standardbehandlung nach brusterhaltender Therapie des Mammakarzinoms. Beim linksseitigen Mammakarzinom wurde allerdings eine erhoehte Rate fataler kardiovaskulaerer Ereignisse infolge einer Exposition des Herzens mit ionisierender Strahlung ermittelt. Es besteht die Hypothese, dass diese kardiale Toxizitaet minimiert werden kann, und zwar durch die Bestrahlung in tiefer Inspiration (DIBH) und die Anwendung aktueller Techniken, insbesondere der intensitaetsmodulierten Radiotherapie (IMRT) und der volumetrischen Rotationsbestrahlung (VMAT). Primaere Zielsetzung dieser Studie war, beim linksseitigen

  10. Predictive and prognostic value of tumor volume and its changes during radical radiotherapy of stage III non-small cell lung cancer. A systematic review

    Energy Technology Data Exchange (ETDEWEB)

    Kaesmann, Lukas [University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); Niyazi, Maximilian; Fleischmann, Daniel [LMU Munich, Department of Radiation Oncology, Munich (Germany); German Cancer Consortium (DKTK), partner site Munich, Munich (Germany); German Cancer Research Center (DKFZ), Heidelberg (Germany); Blanck, Oliver; Baumann, Rene [University Medical Center Schleswig-Holstein, Department of Radiation Oncology, Kiel (Germany); Baues, Christian; Klook, Lisa; Rosenbrock, Johannes; Trommer-Nestler, Maike [University Hospital of Cologne, Department of Radiotherapy, Cologne (Germany); Dobiasch, Sophie [Technische Universitaet Muenchen, Department of Radiation Oncology, Munich (Germany); Eze, Chukwuka [LMU Munich, Department of Radiation Oncology, Munich (Germany); Gauer, Tobias; Goy, Yvonne [University Medical Center Hamburg-Eppendorf, Department of Radiotherapy and Radio-Oncology, Hamburg (Germany); Giordano, Frank A.; Sautter, Lisa [University Medical Center Mannheim, Department of Radiation Oncology, Mannheim (Germany); Hausmann, Jan [University Medical Center Duesseldorf, Department of Radiation Oncology, Duesseldorf (Germany); Henkenberens, Christoph [Hannover Medical School, Department of Radiation and Special Oncology, Hannover (Germany); Kaul, David; Thieme, Alexander H. [Charite School of Medicine and University Hospital, Campus Virchow-Klinikum, Department of Radiation Oncology, Berlin (Germany); Krug, David; Schmitt, Daniela [University Hospital Heidelberg and National Center for Radiation Research in Oncology (NCRO) and Heidelberg Institute for Radiation Oncology (HIRO), Department of Radiation Oncology, Heidelberg (Germany); Maeurer, Matthias [University Medical Center Jena, Department of Radiation Oncology, Jena (Germany); Panje, Cedric M. [Kantonsspital St. Gallen, Department of Radiation Oncology, St. Gallen (Switzerland); Suess, Christoph [University Medical Center Regensburg, Department of Radiation Oncology, Regensburg (Germany); Ziegler, Sonia [University Medical Center Erlangen, Department of Radiation Oncology, Erlangen (Germany); Ebert, Nadja [University Medical Center Dresden, Department of Radiation Oncology, Dresden (Germany); OncoRay - National Center for Radiation Research in Oncology, Dresden (Germany); Medenwald, Daniel [Martin Luther University Halle-Wittenberg, Department of Radiation Oncology, Faculty of Medicine, Halle (Germany); Ostheimer, Christian [Martin Luther University Halle-Wittenberg, Department of Radiation Oncology, Faculty of Medicine, Halle (Germany); Klinik und Poliklinik fuer Strahlentherapie, Universitaetsklinikum Halle (Saale) (Germany); Collaboration: Young DEGRO Trial Group

    2018-02-15

    . Several potential confounding variables were found and need to be considered for future studies to evaluate GTV changes during definitive radiotherapy with respect to treatment outcome. (orig.) [German] Das Bronchialkarzinom ist die haeufigste Ursache krebsbedingter Mortalitaet weltweit. Das Stadium III des nicht-kleinzelligen Bronchialkarzinoms (NSCLC) praesentiert sich als heterogene Patientengruppe mit Lymphknotenbeteiligung und grossen Tumoren mit Infiltration von Mediastinum, Herz und Wirbelsaeule. Ein interdisziplinaeres Behandlungskonzept mit Strahlentherapie ist Therapiestandard in der Behandlung des Stadium III mit akzeptabler Toxizitaet und verbessertem klinischen Ergebnis hinsichtlich lokaler Kontrolle. Veraenderungen des Tumorvolumens (GTV) unter Strahlentherapie ermoeglichen eine adaptive Bestrahlungsplanung mit Normalgewebeschonung und Dosiseskalation. Durchgefuehrt wurde eine Literaturrecherche zum praediktiven Wert von GTV-Veraenderungen unter Strahlentherapie mit dem Endpunkt ''Gesamtueberleben''. Die Recherche wurde in einem zweistufigen Verfahren unter Verwendung von Medline/Pubmed mit den Stichwoertern ''stage III non-small cell lung cancer'' und ''radiotherapy'' und ''tumour volume'' und ''prognostic factors'' durchgefuehrt. Nach finaler Bewertung blieben 17, 14 und 9 Studien mit 2516, 784 und 639 Patienten zum praediktiven Einfluss von GTV, GTV-Veraenderung und dessen Einfluss auf das Gesamtueberleben uebrig und wurden in den Review aufgenommen. Das initiale GTV war in verschiedenen Studien ein wichtiger prognostischer Faktor fuer das Gesamtueberleben. Zeitpunkt der Evaluation und Einfluss der Histologie muessen jedoch weiter untersucht werden. GTV-Veraenderungen unter Strahlentherapie variieren sehr. Der optimale Zeitpunkt fuer eine Reevaluation des GTVs fuer den praediktiven Wert auf die Prognose ist unklar. Der prognostische Wert von GTV

  11. Role of postoperative radiotherapy in the management of malignant pleural mesothelioma. A propensity score matching of the SEER database

    Energy Technology Data Exchange (ETDEWEB)

    Abdel-Rahman, Omar [Ain Shams University, Clinical Oncology department, Faculty of medicine, Cairo (Egypt)

    2017-04-15

    This study assessed the prognostic impact of postoperative radiotherapy in patients with surgically resected malignant pleural mesothelioma (MPM). MPM patients diagnosed between 2000 and 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. A propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TNM stage, and type of surgery). A total of 2166 patients were identified. The median age was 60 years (range 25-85 years), and 469 patients received postoperative radiotherapy. Both before and after propensity score matching, overall survival (P < 0.0001 and P = 0.012, respectively) was better in the postoperative radiotherapy group. When the overall survival was stratified by histology, postoperative radiotherapy did not improve the survival in sarcomatoid histology patients both before and after matching (P = 0.424 and P = 0.281, respectively). In multivariate analysis of the matched population, not receiving postoperative radiotherapy did not correlate with worse survival (hazard ratio: 1.175; P = 0.12). Factors associated with worse survival include sarcomatoid histology, nodal positivity, and age ≥70. Evidence from this analysis is insufficient on its own to routinely recommend postoperative radiotherapy for surgically resected MPM. However, large-scale prospective clinical trials are warranted to further evaluate this intervention in nonsarcomatoid histology. (orig.) [German] In der vorliegenden Studie wurde der prognostische Einfluss der postoperativen Strahlentherapie bei Patienten mit chirurgisch reseziertem malignem Pleuramesotheliom (MPM) untersucht. In der SEER-Datenbank (Surveillance, Epidemiology, and End Results) wurden Patienten ermittelt, bei denen zwischen 2000 und 2013 die Diagnose eines MPM gestellt worden war. Unter Beruecksichtigung der Ausgangsmerkmale (Alter, Geschlecht, Ethnizitaet, Histologie, TNM-Stadium und Art des chirurgischen Eingriffs) wurde eine

  12. Unusual acute and delayed skin reactions during and after whole-brain radiotherapy in combination with the BRAF inhibitor vemurafenib. Two case reports

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, B.; Roedel, C.; Weiss, C. [Johann Wolfgang Goethe-University Hospital, Department of Radiation Oncology, Frankfurt am Main (Germany); Meissner, M.; Wolter, M. [Johann Wolfgang Goethe-University Hospital, Department of Dermatology, Frankfurt am Main (Germany)

    2014-02-15

    Besides radiotherapy (RT) and surgery, the introduction of BRAF inhibitors like vemurafenib has provided new opportunities for treatment of patients with metastasized malignant melanomas. RT and vemurafenib are being increasingly used concurrently, although little is known about the potential side effects of this combination. Vemurafenib is known to cause severe cutaneous skin reactions such as phototoxicity and evidence is accumulating that RT may further enhance these side effects. We report two cases of unusual skin reactions occurring during and after treatment with a combination of vemurafenib and whole-brain irradiation in patients with cerebral metastases arising from malignant melanomas. One case report describes excessive acute radiodermatitis which arose during whole-brain irradiation in combination with vemurafenib. The second describes a late skin reaction occurring approximately 30 days after completion of RT. These two case reports show that combination of both treatment modalities is possible, but requires close monitoring of patients and good interdisciplinary collaboration. (orig.) [German] Neben der Strahlentherapie und Chirurgie stellt die Einfuehrung von BRAF-Inhibitoren wie Vemurafenib eine neue Moeglichkeit zur Behandlung von metastasierten malignen Melanomen dar und immer haeufiger kommt eine Kombination aus Strahlentherapie und Vemurafenib zum Einsatz. Bislang ist wenig bekannt ueber potentielle Nebenwirkungen, die sich aus einer Kombination beider Therapieoptionen ergeben koennen. Vemurafenib kann zu schweren kutanen Nebenwirkungen wie z. B. Phototoxizitaet fuehren und es haeufen sich Hinweise, dass die Strahlentherapie diese Nebenwirkungen verstaerken kann. Wir berichten ueber zwei Faelle ungewoehnlicher Hautreaktionen waehrend und nach einer Ganzhirnbestrahlung in Kombination mit Vemurafenib. Ein Fall beschreibt eine akute und ueberschiessende Radiodermatitis unter fortlaufender Radiotherapie und der andere Fall beschreibt eine spaete

  13. Essential role of radiation therapy for the treatment of pancreatic cancer. Novel study concepts and established treatment recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Dobiasch, Sophie [Technical University of Munich (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Goerig, Nicole L.; Fietkau, Rainer [Friedrich-Alexander-Universitaet Erlangen-Nuernberg, Department of Radiation Oncology, Universitaetsklinikum Erlangen, Erlangen (Germany); Combs, Stephanie E. [Technical University of Munich (TUM), Department of Radiation Oncology, Klinikum rechts der Isar, Munich (Germany); Helmholtz Zentrum Muenchen, Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Neuherberg (Germany)

    2018-03-15

    Pancreatic cancer is one of the most aggressive human tumors and the incidence has increased over the last 6 years. In the majority of cases the disease is already in an advanced stage at the time of diagnosis where surgery, the only curative treatment, is no longer an option and explains the still abysmal overall survival. The role of radiation therapy as treatment option for patients with pancreatic cancer is controversially discussed although radiation oncology has emerged as a central pillar in the combined oncological treatment. The present manuscript gives an overview of advanced radiotherapeutic strategies in the context of chemotherapy and surgery according to the current American Society of Clinical Oncology (ASCO) guidelines in comparison with the German guidelines and to elucidate the role of radiation therapy for the treatment of pancreatic cancer. Advanced modern radiotherapeutic techniques in combination with individualized high-precision radiation concepts are new therapeutic approaches for pancreatic cancer in a multimodal setting with tolerable side effects. Several clinical studies together with experimental approaches are in process, to deliver further evidence and ultimately allow true personalized medicine. (orig.) [German] Das Pankreaskarzinom gehoert zu den aggressivsten menschlichen Tumoren und verzeichnete in den letzten 6 Jahren eine steigende Inzidenz. Die Diagnose wird meist erst im fortgeschrittenen Stadium gestellt; dies schliesst haeufig eine primaer kurative Intervention mithilfe der chirurgischen Resektion aus und bedingt die hohe Mortalitaet. Obwohl die Strahlentherapie im multimodalen Therapieansatz des Pankreaskarzinoms eine zentrale Saeule darstellt, wird die Rolle der Strahlentherapie in der Literatur kontrovers diskutiert. Der vorliegende Beitrag bietet eine Uebersicht moderner Bestrahlungsstrategien im interdisziplinaeren Konzept gemaess der Leitlinien der American Society of Clinical Oncology (ASCO) im Vergleich zu den

  14. Simulation of pendulum shock experiments on a passenger car front axle; Simulation von Pendelschlagversuchen an einer PKW-Vorderachse

    Energy Technology Data Exchange (ETDEWEB)

    Sporer, L.; Witt, R.; Muehlbauer, R. [BMW Group, Muenchen (Germany)

    2001-07-01

    The contribution describes the development and application of a method for simulating loads resulting from misuse on car body components. The development of the method and its validation by experiments are described, and its application in the development of the BMW-5 series is gone into. [German] Der Beitrag beschreibt die Entwicklung und Anwendung einer Methode zur Simulation von Missbrauchsbelastungen an Fahrwerkskomponenten. Im ersten Abschnitt ist die systematische Entstehung der Methode und die Absicherung der Simulationsergebnisse durch Ersatzversuche dargestellt. In den folgenden Abschnitten steht die Anwendung der Methode in der Fahrwerksentwicklung bei BMW am Beispiel der Vorderachse der aktuellen 5-er Baureihe im Vordergrund. Das Deformationsverhalten einzelner Lenker bzw. die Schadenskette an der gesamten Achse werden sowohl fuer den seitlichen, als auch fuer den frontalen Pendelschlag aufgezeigt. (orig.)

  15. Composting of biological waste. Processes and utilisation. Summary report; Bioabfallkompostierung. Verfahren und Verwertung. Kurzfassung

    Energy Technology Data Exchange (ETDEWEB)

    Gronauer, A.; Claassen, N.; Ebertseder, T.; Fischer, P.; Gutser, R.; Helm, M.; Popp, L.; Schoen, H.

    1997-12-31

    The project investigated environmentally compatible concepts for processing and utilisation of biological waste by means of composting and spreading on agriculataural and gardening plots. The project comprised three parts: Composting techniques, applications of compost in agriculture and gardening, and applications in landscaping. This volume comprises the summaries of the three part-projects. (orig./SR) [Deutsch] Die umweltschonende Aufbereitung und Verwertung von Bioabfall durch Kompostierung und Rueckfuehrung auf landwirtschaftliche und gaertnerische Flaechen wurde untersucht. Dieses Projekt war dreigeteilt in die Bereiche der Kompostierung selbst, der Anwendung des Komposts in der Landwirtschaft und seiner Anwendung im Gartenbau sowie im Garten- und Landschaftsbau (GaLa-Bau). Die vorliegende Schrift enthaelt die Zusammenfassung der genannten drei Teilberichte. (orig./SR)

  16. Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Merten, Ricarda; Hecht, Markus; Haderlein, Marlen; Distel, Luitpold; Fietkau, Rainer; Semrau, Sabine [Department of Radiation Oncology University Hospital Erlangen, Erlangen (Germany); Heinzerling, Lucie [University Hospital Erlangen, Department of Dermatology, Erlangen (Germany)

    2014-12-15

    Palliative radiotherapy is often required for patients with metastatic malignant melanoma in the case of bone or brain metastases. Since BRAF inhibitor therapy is highly efficient in V600-mutated melanomas, there is hesitation to stop it during radiotherapy. Consequently, radiotherapy under simultaneous vemurafenib treatment is frequently needed. We report the case of a patient receiving palliative radiotherapy of spinal bone metastases before and during vemurafenib therapy. The skin reactions were quantitatively scored using computer-assisted digital image evaluation. Radiotherapy without vemurafenib was tolerated very well, whereas radiotherapy under simultaneous vemurafenib treatment resulted in accentuated skin reactions. Furthermore, the patient developed dysphagia and had to be hospitalized for parenteral nutrition. In the quantitative analysis, there was a twofold increase in pigmentation and erythema of the irradiated skin area of the thoracic spine when vemurafenib was combined with radiotherapy compared with radiotherapy treatment alone. This is the first reported case of a patient showing no complications during radiotherapy without vemurafenib but remarkable skin and mucosal toxicity under concurrent vemurafenib therapy. Thus, a genetically conditioned individually elevated radiosensitivity can definitely be excluded. Compared with other reported cases, radiosensitization was not limited to the skin, but also affected the esophageal mucosa. Vemurafenib is a strong radiosensitizer. Patients receiving radiotherapy under simultaneous vemurafenib treatment should be monitored very closely. (orig.) [German] Bei Patienten mit metastasiertem Melanom ist die palliative Bestrahlung von Knochen- oder Hirnmetastasen haeufig erforderlich. Da eine Therapie mit BRAF-Inhibitoren bei Patienten mit V600-mutierten Melanomen hoch effektiv ist, sollte man sie waehrend einer Strahlentherapie nicht unterbrechen. Daher ist eine Strahlentherapie unter laufender Behandlung mit

  17. A chronicle of radiotherapy, 1900-1960. Selected chapters of the German literature in the field of radiooncology. Vol. 1

    International Nuclear Information System (INIS)

    Scherer, E.

    1992-01-01

    This is the first publication to review the history of development of radiotherapy as a method of treatment, starting with the first publications form the fields of dermatology, gynecology, surgery and internal medicine, showing the whole way up to the emergence of radiooncology as an independent field of work. The most important monographies and many other contributions published in the years from 1912 to 1925 in the journal 'Strahlentherapie und Onkologie' have been compiled in this book to illustrate the various phases of development of techniques and methods as well as of research in the field of physics, or radiobiology. (orig.) [de

  18. Kombinierte elektromagnetische Vollwellen- und strahlbasierte Simulationen von Fahrzeugantennen in virtuellen Testfahrten

    OpenAIRE

    Mocker-Henning, Marina

    2016-01-01

    In dieser Arbeit werden elektromagnetische Untersuchungen von Fahrzeugantennen für verschiedene Dienste in virtuellen Testfahrten unter Anwendung einer Kombination aus Vollwellen- und Ray Tracing- Methoden simulativ durchgeführt. Es werden verschiedene Vollwellen- Lösungsverfahren und -Lösermethoden vorgestellt und verglichen. Für die Berechnung der Ausbreitung elektromagnetischer Wellen im mobilen Szenario wird ein Ray Tracing Programm entwickelt, das für eine hohe Berechnungsgeschwindigkeit...

  19. Review: Anja Weiß (2001). Rassismus wider Willen. Ein anderer Blick auf eine Struktur sozialer Ungleichheit

    OpenAIRE

    Bremer, Helmut

    2002-01-01

    Die Arbeit liefert einen Beitrag zur Debatte um Rassismus und Interkulturalität sowie zur Anwendung qualitativer Forschungsverfahren im Rahmen der Theorie BOURDIEUs. Rassismus und Anti-Rassismus werden nicht isoliert betrachtet, sondern als eine Dimension sozialer Ungleichheit, die in eine umfassende Theorie sozialer Ungleichheit eingebunden werden muss. Vorgeschlagen wird BOURDIEUs Konzept von Habitus, Feld und Kapital. Das ermöglicht einen anderen Blick auf das Phänomen. Rassismus reproduzi...

  20. Konzeptionelle Entwicklung innovativer Bremssysteme

    OpenAIRE

    Schwankl, L.

    2017-01-01

    Im Rahmen des hier vorgestellten Kooperationsprojekts wurden vorhandene elektromagnetische Bremsen nach konstruktionsmethodischen Gesichtspunkten überarbeitet. Nach einer intensiven Auseinandersetzung mit dem bestehenden System wurde unter Anwendung unterschiedlichster Kreativitätstechniken eine große Anzahl von neuen Lösungsvorschlägen erarbeitet und dokumentiert. Bereits in den frühen Phasen der Produktentwicklung wurden die relevanten, produktbestimmenden Eigenschaften mittels einfacher An...

  1. Ketal-Synthese mit Brønsted-aciden ionischen Flüssigkeiten als Katalysator in zweiphasigen Reaktionssystemen

    OpenAIRE

    Thomann, Michael

    2017-01-01

    In dieser Arbeit wurde ein neuartiges Verfahren zur Produktion von 2,2-Dimethoxypropan (DMP) aus Aceton und Methanol unter Verwendung von Brønsted-aciden ionischen Flüssigkeiten (BAILs) als Katalysator in einer flüssig-flüssig Zweiphasenreaktion entwickelt. Darüber hinaus wurde die Anwendung des neuartigen Zweiphasenprozesses in der Herstellung von Ketalen aus höhermolekularen linearen Ketonen, insbesondere 2-Butanon, und Methanol demonstriert. Im Unterschied zu bisher publizierten Verfahren ...

  2. Einfluss hochfrequenter Felder des Mobilfunks auf das blutbildende System in vitro

    OpenAIRE

    Gläser, Katharina

    2017-01-01

    Elektromagnetische Felder (EMF) sind in der Umwelt des Menschen allgegenwärtig. Unter Verwendung unterschiedlicher Frequenzen bilden sie die Grundlage zahlreicher Technologien und begegnen uns im Alltag in einer Vielzahl von Anwendungen. Eine sehr wichtige Anwendung von EMF ist die mobile Kommunikation. Die hierfür verwendeten Frequenzen liegen im hochfrequenten Bereich und variieren mit dem Mobilfunkstandard. Weit verbreitet ist die GSM- und UMTS-Modulation der zweiten (2G) und dritten Gener...

  3. Do-it-yourself-Fragebogen-App am Beispiel des Fragebogens zur Erfassung des Stimmlichen Selbstkonzepts

    OpenAIRE

    Lehnert, B

    2017-01-01

    Hintergrund: Validierte Fragebögen ergänzen die Anamnese. Gegenüber der klassischen Anwendung mit Stift und Papier kann die Befragung mit mobilen Computern Vorteile haben: Erfassung, Auswertung und Dokumentation sind weniger zeit- und fehleranfällig. Durch das elektronische Interface kann unklares Antwortverhalten vermieden werden (keine Kreuzchen zwischen den Kästchen etc.). Ein Mobiltelefon kann beliebig viele Fragebögen bevorraten und passt doch in die Kitteltasche.Papierformen der Frageb...

  4. Berichte zu Pflanzenschutzmitteln 2010 Jahresbericht Pflanzenschutz-Kontrollprogramm

    CERN Document Server

    Dombrowski, Saskia

    2012-01-01

    In der Bundesrepublik Deutschland überwachen die Länderbehörden die Einhaltung der Vorschriften für das Inverkehrbringen und die Anwendung von Pflanzenschutzmitteln. 2010 wurden bundesweit 2558 Handelsbetriebe sowie 4909 land- und forstwirtschaftliche sowie Gartenbau-Betriebe kontrolliert. Darüber hinaus haben Kontrollstellen fast 100 Tausend Pflanzenschutzgeräte überprüft und die physikalischen, chemischen und technischen Eigenschaften von 157 Pflanzenschutzmitteln untersucht. Der vorliegende Bericht fasst die Ergebnisse dieser Kontrollen zusammen.

  5. Investigations on the effect of creep stress on the thermal properties of metallic materials; Untersuchungen zum Einfluss der Zeitstandbeanspruchung auf die thermischen Eigenschaften metallischer Werkstoffe

    Energy Technology Data Exchange (ETDEWEB)

    Radtke, U [Univ. Dortmund (Germany); Crostack, H A [Univ. Dortmund (Germany); Winschuh, E [Siemens KWU, Offenbach (Germany)

    1996-12-31

    Using thermal wave analysis with front side infrared detection on sample material damaged by creep, one examines whether the creep stress has an effect on the thermal material properties and to what effect this can be used to estimate the remaining service life. (orig.) [Deutsch] Unter Anwendung der Waermewellenanalyse mit frontseitiger Infrarotdetektion auf zeitstandgeschaedigtes Probenmaterial wird untersucht, ob die Zeitstandbeanspruchung einen Einfluss auf die thermischen Werkstoffeigenschaften hat und inwieweit dieser zur Abschaetzung der Restlebensdauer genutzt werden kann. (orig.)

  6. The new radiation protection ordinance from the viewpoint of the researcher in nuclear medicine; Die neue Strahlenschutzverordnung aus der Sicht des in der Forschung taetigen Nuklearmediziners

    Energy Technology Data Exchange (ETDEWEB)

    Reiners, Chr.; Lassmann, M. [Klinik und Poliklinik fuer Nuklearmedizin der Univ. Wuerzburg (Germany)

    2002-05-01

    After the new radiation protection ordinance has come into effect with July 20th, 2001 the approval process for application of radiation substances or ionizing radiation in medical research changed considerably with respect to the responsibility of the Federal Office for Radiation Protection as the approval authority, the participation of an approved ethic committee, the inclusion of an expert for medical physics for planning and execution of the study as well as stricter regulations for cover clause. On the contrary, existing regulations have been facilitated since the effective dose limit for volunteers has been increased from 10 to 20 mSv and a central procedure for approval of multicenter studies has been introduced. Moreover, the application of radioactive substances or ionizing radiation for research in people without or with restricted legal capacity is no more totally prohibited. At present, changes of the radiation protection ordinance and the atomic law cover clause ordinance with respect to medical research are in discussion. (orig.) [German] Nach In-Kraft-Treten der neuen Strahlenschutzverordnung vom 20.07.2001 ergeben sich wesentliche Aenderungen des Genehmigungsverfahrens fuer die Anwendung radioaktiver Stoffe oder ionisierender Strahlung in der medizinischen Forschung bezueglich der Zustaendligkeit des Bundesamts fuer Strahlenschutz als Genehmigungsbehoerde, der Einschaltung einer akkreditierten Ethikkommission, der Hinzuziehung eines Medizinphysik-Experten bei der Studien-Planung und -Anwendung sowie verschaerfter Regelungen zur Deckungsvorsorge. Eine gewisse Erleichterung bisher bestehender Regelungen ist in der Erhoehung des Grenzwerts der effektiven Dosis fuer Probanden von 10 auf 20 mSv sowie dem zentralen Genehmigungsverfahren fuer Multizenter-Studien zu sehen. Ausserdem ist eine Anwendung radioaktiver Stoffe oder ionisierender Strahlung in der Forschung an geschaeftsunfaehigen und beschraenkt geschaeftsfaehigen Probanden nicht mehr voellig

  7. Generative Fertigung im Maschinenbau - industrieller 3D-Druck auf dem Weg in die Serienproduktion

    OpenAIRE

    Müller, Bernhard

    2014-01-01

    3D-Druck ist aktuell medial omnipräsent, sein Potential für echte industrielle Anwendungen, v. a. im Maschinenbauumfeld, wird kontrovers diskutiert. Der Vortrag gibt einen fundierten Einblick in den Stand der Technik zum industriellen 3D-Druck (Generative Fertigung , Additive Manufacturing) und zeigt spezifische Potentiale mit industrieller Relevanz auf. Dabei werden ebenso Praxisbeispiele aus heutiger Anwendung in der Industrie gezeigt als auch Zukunftsszenarien für potentielle Anwendungen e...

  8. Bestimmung der optimalen Array-Apertur für die Ultraschallprüfung von faserverstärkten Kunststoffen

    OpenAIRE

    Kurras, Martin

    2017-01-01

    Für die zerstörungsfreie Prüfung von Kohlenstofffaserverbundwerkstoffen (CFK) wird häufig die Ultraschallprüfung verwendet. Neben dem klassischen Ultraschallverfahren findet dabei auch die Phased Array Technologie Anwendung. Hierbei wird zwischen zwei Verfahren unterschieden: dem handelsüblichen Phased Array oder Conventional Phased Array (CPA) und dem tomographischen Sampling Phased Array (SPA). Der Einsatz von Phased Arrays im Zusammenhang mit Linear-Scan-Technik und das sich daraus ergeben...

  9. Geschäftsmodelle in der digitalen Wirtschaft. Vollstudie

    OpenAIRE

    Müller, Simon C.; Böhm, Markus; Schröer, Marina; Bahkirev, Alexander; Baiasu, Bogdan-Cristian; Krcmar, Helmut; Welpe, Isabell M.

    2016-01-01

    Selten zuvor haben neuartige Konzepte und Technologien überall auf der Welt so schnell und weitreichend gesellschaftliche und wirtschaftliche Anwendung gefunden wie digitale Geschäftsmodelle und Smartphones in den letzten zehn Jahren. Meilensteine der Entwicklung waren der Beginn der Digitalisierung ganzer Bibliotheken beginnend mit dem Jahr 2005 und die Markteinführung des iPhones im Jahr 2007. Die digitale Transformation stellt Politik und Wirtschaft vor große Herausforderungen. Für eine fu...

  10. Introduction of a Diagnosis Related Groups’ Case Flat Rate System: Hopes and Fears (einfuerhrng eines drg-fallpauschalensystems - hoffnungen und aengste)

    Science.gov (United States)

    2000-06-01

    Anwendung und Pflege des neuen Systems dienen soil, wenn die entscheidenden Vorgaben bereits durch die Deckelung gegeben sind. Oder denkt man an den...Software und die da- mit verbundenen Lizenzgebuhren, sondern auch in der Folge um die Schulung der Mitarbeiter sowie die Pflege und Weiterentwicklung...sung an die medizinische Entwicklung" sowie von "Verfahren zur laufen- den Pflege des VergOtungssystems" gesprochen. Es mossen jedoch klare

  11. Trennung und Rekombination von Ladungsträgern in Solarzellen mit nanostrukturierter ZnO-Elektrode

    OpenAIRE

    Tornow, Julian

    2010-01-01

    In dieser Arbeit werden Elektroden aus hydrothermal auf leitfähigem Glassubstrat (Leitglas) abgeschiedenen ZnO-Nanostangen betrachtet. Die Elektroden selbst sind für sichtbares Licht transparent und werden für eine Anwendung als Solarzelle mit einer lichtabsorbierenden Schicht sensibilisiert; hier sind das entweder metallorganische Farbstoffmoleküle (N3) oder eine nur wenige Nanometer dicke Schicht aus Indiumsulfid. Für die elektrische Kontaktierung der sensibilisierten Elektrode wird entwed...

  12. Ein Richdata-Konzept für Virtuelle Realität dargestellt am Beispiel der Fahrzeugkonfiguration

    OpenAIRE

    Ni, Cheng

    2011-01-01

    Die Integration ist einer der wichtigsten Erfolgsfaktoren für den VR-Einsatz im industriellen Entwicklungs- und Produktionsprozess. Ausgereifte integrierte VR-Lösungen benötigen vielfältige Informationsformen, um neben der visuellen Szene auch die Beschreibung, Logik, Überwachung und Kontrollierbarkeit des zu integrierenden Prozesses in der VR-Anwendung darzustellen. In VR wurden sie allerdings bisher nicht in der gleichen Intensität wie die Erzeugung, Verarbeitung und Anzeige von Geometrieda...

  13. Vergleichende Kraft-Dehnungs- und Dauerlastversuche mit kieferorthopädischen Gummizügen und pseudoelastischen Ni-Ti-Federn

    OpenAIRE

    Buch, Stefan

    2003-01-01

    Bei einer Behandlung mit festsitzenden Apparaturen stehen für Zahnverschiebungen in mesio-distaler Richtung und zur Okklusionseinstellung seit 1993 als Alternative zu Gummiringen aus Latex Zugfedern aus der Nickel-Titan-Legierung Sentalloy zur Verfügung. Die vorliegende Untersuchung zeigt die materialtechnischen Besonderheiten der beiden Werkstoffe auf und beschreibt die Vor- und Nachteile in der klinischen Anwendung der Gummizüge und der Federn. Es wurden Gummizüge aus Latex von Ormco Dental...

  14. Therapy-induced effects in normal tissue; Therapieinduzierte Effekte am Normalgewebe

    Energy Technology Data Exchange (ETDEWEB)

    Kaick, G. van; Delorme, S. [Deutsches Krebsforschungszentrum (DKFZ), Abteilung E010 - Radiologie, Heidelberg (Germany)

    2008-09-15

    More than 50% of cancer patients survive for more than 5 years, owing to modern and effective treatment. Therefore, long-term sequelae of treatment are more frequently seen than in the past. Such effects on normal tissue may both mimic and obscure tumor recurrences. Besides the direct consequences of surgery, tissue damage due to radiation or chemotherapy frequently cause problems in differential diagnosis. Among the numerous sequelae of radiotherapy, the most prominent are disturbance of the blood-brain barrier, radiation pneumonitis, osteodystrophy and osteoradionecrosis, fatty changes of bone marrow, or increased radiodensity of breast parenchyma. Chemotherapy may cause, e.g., diffuse abnormalities of white matter, pneumonitis and lung fibrosis, cardiomyopathy, or diffuse and patchy changes in bone marrow signals in MRI. The most devastating long-term complications are secondary cancers and leukemia induced by both radiotherapy and chemotherapy. (orig.) [German] Mehr als 50% der Tumorpatienten ueberleben dank moderner Therapie laenger als 5 Jahre, sodass die Spaetfolgen am gesunden Gewebe haeufiger und genauer erfasst werden. Diese koennen Tumorrezidive sowohl verschleiern als auch vortaeuschen. Neben den unmittelbaren Folgen operativer Eingriffe sind Auswirkungen der Chemo- und Strahlentherapie ein haeufiges differenzialdiagnostisches Problem. Wichtige Folgen einer Strahlentherapie sind z. B. Blut-Hirn-Schranken-Stoerungen, Strahlenpneumonitis, Osteodystrophie und -radionekrose, Verfettung des blutbildenden Knochenmarks oder Parenchymverdichtungen der Brust. Chemotherapie kann u. a. zur Leukenzephalopathie, Pneumonitis und Lungenfibrose, Kardiomyopathie sowie zu diffusen und fleckfoermigen Signalaenderungen des Knochenmarks in der MRT fuehren. Die schwerstwiegende Spaetkomplikation ist die Induktion solider Zweittumoren und Leukaemien sowohl nach Strahlen- als auch Chemotherapie. (orig.)

  15. Survival and prognostic factors after moderately hypofractionated palliative thoracic radiotherapy for non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Oorschot, B. van; Assenbrunner, B.; Beckmann, G.; Flentje, M. [Universitaetsklinikum Wuerzburg, Interdisziplinaeres Zentrum Palliativmedizin, Klinik und Poliklinik fuer Strahlentherapie, Wuerzburg (Germany); Schuler, M. [Universitaet Wuerzburg, Abteilung fuer Medizinische Psychologie und Psychotherapie, Medizinische Soziologie und Rehabilitationswissenschaften, Wuerzburg (Germany)

    2014-03-15

    Survival and prognostic variables in patients with advanced or metastatic non-small cell lung cancer (NSCLC) requiring thoracic palliative radiotherapy using a moderately hypofractionated regime (13-15 x 3 Gy) were evaluated. From March 2006 to April 2012, 120 patients with a physician estimated prognosis of 6-12 months were treated with this regime using CT-based 3D conformal radiotherapy. We collected data on patient characteristics, comorbidities, toxicity, and treatment parameters. Radiotherapy was completed as prescribed in 114 patients (95.0 %, premature termination 5.0 %). Acute grade 3 toxicity was seen in 6.4 % of patients. The median survival of all patients was 5.8 months. Nonmetastatic patients survived significantly longer than patients with metastatic disease (median 11.7 months vs 4.7 months, p = 0.0001) and 18.6 % of nonmetastatic patients survived longer than 2 years. In 12.7 % radiotherapy started less than 30 days before death and 14.2 % of patients received radiotherapy within 14 days before death. In the multivariate analysis, good general condition, nonmetastatic disease, and a stable or improved general condition at the end of radiotherapy were significant. The treatment parameters, age, and comorbidities were not statistically significant. Our data confirm considerable effectiveness of 13 x 3 Gy with conformal radiotherapy for patients with locally confined NSCLC not fit for radical treatment and raise doubt for this regimen in metastatic patients and ECOG ≥ 2 when burden, acute toxicity, and resources are considered. (orig.) [German] Analyse der Ueberlebenszeiten und prognoserelevanter Variablen von Patienten mit lokal fortgeschrittenem und metastasiertem nicht-kleinzelligen Lungenkrebs nach moderat hypofraktionierter Strahlentherapie (13- bis 15-mal 3 Gy). Zwischen Maerz 2006 und April 2012 wurden 120 Patienten mit aerztlich eingeschaetzter Lebenserwartung von 6-12 Monaten mit diesem Regime mittels CT-basierter 3-D

  16. Clinical decisions in breast cancer, a heterogenous disease

    OpenAIRE

    Braga, Sofia Souto

    2014-01-01

    RESUMO: Introdução: Tratamento do carcinoma da mama Este trabalho inicia-se com a história do tratamento do carcinoma da mama, desde os primeiros documentos que descrevem doentes com carcinoma da mama até 1950. Desde 1950 até 2000 o diagnóstico, risco e as modalidades terapêuticas usadas no tratamento das doentes são mais detalhadas com ênfase nas terapêuticas locais, regionais e sistémicas. Parte 1:Quem tratar com terapêutica sistémica adjuvante Capítulo 1: A classificação ...

  17. Farmacocinética, metabolismo e excreção renal da doxorrubicina em pacientes com câncer de mama

    OpenAIRE

    Leandro Francisco Pippa

    2016-01-01

    O presente estudo visa descrever a farmacocinética, o metabolismo e a excreção renal da doxorrubicina, uma antraciclina utilizada no tratamento do câncer de mama. A doxorrubicina é biotransformada a doxorrubicinol pelas enzimas carbonil redutase 1 e 3 e aldo-ceto redutase. Foram investigadas 12 pacientes portadoras de câncer de mama no primeiro ciclo de tratamento adjuvante ou neoadjuvante com doxorrubicina (60 mg/m2) administrada por infusão intravenosa durante 30 min. As amostras seriadas d...

  18. Rotavirus 2/6 Viruslike Particles Administered Intranasally with Cholera Toxin, Escherichia coli Heat-Labile Toxin (LT), and LT-R192G Induce Protection from Rotavirus Challenge

    OpenAIRE

    O’Neal, Christine M.; Clements, John D.; Estes, Mary K.; Conner, Margaret E.

    1998-01-01

    We have shown that rotavirus 2/6 viruslike particles composed of proteins VP2 and VP6 (2/6-VLPs) administered to mice intranasally with cholera toxin (CT) induced protection from rotavirus challenge, as measured by virus shedding. Since it is unclear if CT will be approved for human use, we evaluated the adjuvanticity of Escherichia coli heat-labile toxin (LT) and LT-R192G. Mice were inoculated intranasally with 10 μg of 2/6-VLPs combined with CT, LT, or LT-R192G. All three adjuvants induced ...

  19. Caracterização reológica de argamassas

    OpenAIRE

    Paiva, Helena Maria da Costa

    2005-01-01

    O presente trabalho é realizado com o objectivo geral de estudar o comportamento reológico de argamassas. Pretende-se, por um lado, desenvolver um procedimento adequado para a análise reológica de uma argamassa e, por outro lado, avaliar o efeito de alguns adjuvantes essenciais à sua formulação sobre o comportamento reológico de uma argamassa específica (do tipo monomassa). Procura-se também estabelecer, sempre que possível, uma correlação entre a avaliação reométrica com um...

  20. N-acetylcysteine for major depressive episodes in bipolar disorder N-acetilcisteína para o tratamento de episódios de depressão maior no transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Pedro V Magalhães

    2011-12-01

    Full Text Available OBJECTIVE: In this report, we aimed to evaluate the effect of add-on N-acetylcysteine (NAC on depressive symptoms and functional outcomes in bipolar disorder. To that end, we conducted a secondary analysis of all patients meeting full criteria for a depressive episode in a placebo controlled trial of adjunctive NAC for bipolar disorder. METHOD: Twenty-four week randomised clinical trial comparing adjunctive NAC and placebo in individuals with bipolar disorder experiencing major depressive episodes. Symptomatic and functional outcome data were collected over the study period. RESULTS: Seventeen participants were available for this report. Very large effect sizes in favor of NAC were found for depressive symptoms and functional outcomes at endpoint. Eight of the ten participants on NAC had a treatment response at endpoint; the same was true for only one of the seven participants allocated to placebo. DISCUSSION: These results indicate that adjunctive NAC may be useful for major depressive episodes in bipolar disorder. Further studies designed to confirm this hypothesis are necessary.OBJETIVO: Neste relato, avaliamos o efeito da N-acetilcisteína (NAC adjuvante em sintomas depressivos e desfechos funcionais no transtorno bipolar. Para isso, conduzimos uma análise secundária de todos os pacientes com critérios diagnósticos para um episódio depressivo em um ensaio clínico randomizado comparando NAC adjuvante com placebo no transtorno bipolar. MÉTODO: Ensaio clínico randomizado comparando NAC adjuvante com placebo para episódios depressivos no transtorno bipolar durante 24 semanas. Desfechos funcionais e sintomáticos foram coletados no período. RESULTADOS: Dezessete participantes estavam disponíveis para esta análise. Tamanhos de efeito grandes foram encontrados para sintomas depressivos e desfechos funcionais. Oito dos dez participantes no grupo da NAC tiveram resposta clínica ao fim do tratamento. O mesmo ocorreu em apenas um dos sete

  1. Carcinoma espinocelular de conjuntiva com evolução para exenteração: relato de caso

    Directory of Open Access Journals (Sweden)

    Larissa Horikawa Satto

    2012-02-01

    Full Text Available Portador de carcinoma espinocelular da conjuntiva teve a lesão removida, com recorrência em outra localização. O paciente recebeu ciclos de 5-Fluoruracila como tratamento adjuvante à remoção cirúrgica, apresentando evolução desfavorável que chegou à exenteração orbitária. São feitos comentários quanto ao uso de antimitóticos no tratamento destas lesões.

  2. Complement propriety and conspiracy in nanomedicine

    DEFF Research Database (Denmark)

    Moghimi, Seyed Moein

    2016-01-01

    The complement system is the first line of body's defense against intruders and it acts as a functional bridge between innate and adaptive arms of the immune system. This commentary examines the key roles of complement activation in response to nanomedicine administration, including nucleic acid...... complexes. These comprise beneficial (eg, adjuvanticity) as well as adverse effects (eg, infusion-related reactions). Pigs (and sheep) are often used as predictive models of nanomedicine-mediated infusion-related reactions in humans. The validity of these models in relation to human responses is questioned...

  3. Avaliação da estabilidade de xaropes contendo aminas aromáticas

    OpenAIRE

    Beatriz Resende Freitas

    2002-01-01

    Atualmente a grande malona dos fármacos apresenta grupamento amínico. Estes quando associados à açúcares redutores ou a outros adjuvantes farmacêuticos contendo carbonila, freqüentemente produzem manchas de escurecimento ou descoloração, a Reação de Maillard pode explicar tal ocorrência. Além de poder comprometer a idoneidade do produto. O presente trabalho tem como objetivo estudar o comportamento de xaropes contendo aminas aromáticas, tendo em vista que a associação entre açúcares e aminas ...

  4. Evaluation of metoclopramide syrups by Bratton-Marshall method

    OpenAIRE

    Freitas, Beatriz Resende; Magalhães, João Fernandes

    2005-01-01

    Atualmente, a maioria dos fármacos apresenta grupamento amínico. Estes quando associados a açúcares redutores ou a outros adjuvantes farmacêuticos contendo carbonila, freqüentemente produzem problemas de estabilidade, comprometendo a idoneidade do produto. A Reação de Maillard pode explicar tal ocorrência. Neste trabalho estudou-se o comportamento de xarope contendo amina aromática, tendo em vista a associação de açúcares e aminas, a Reação de Maillard e problemas de estabilidade. O protótipo...

  5. Effect of magnesium oxide on interfraction prostate motion and rectal filling in prostate cancer radiotherapy. Analysis of a randomized clinical trial

    Energy Technology Data Exchange (ETDEWEB)

    Harder, Annemarie M. den; Kotte, Alexis N.T.J.; Vulpen, Marco van; Lips, Irene M. [University Medical Center Utrecht, Department of Radiation Oncology, Utrecht (Netherlands); Gils, Carla H. van [University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht (Netherlands)

    2014-08-15

    To investigate whether magnesium oxide reduces the interfraction motion of the prostate and the amount of rectal filling and rectal gas, which influences prostate position during radiotherapy for prostate cancer. From December 2008 to February 2010, 92 prostate cancer patients scheduled for intensity-modulated radiotherapy (77 Gy in 35 fractions) using fiducial marker-based position verification were randomly assigned to receive magnesium oxide (500 mg twice a day) or placebo during radiotherapy. In a previous study, we investigated the effect on intrafraction motion and did not find a difference between the treatment arms. Here, we compared the interfraction prostate motion between the two treatment arms as well as the amount of rectal filling and rectal air pockets using pretreatment planning computed tomography and magnetic resonance imaging scans. There was no statistically significant difference between the treatment arms in translation and rotation of the prostate between treatment fractions, except for the rotation around the cranial caudal axis. However, the difference was less than 1 and therefore considered not clinically relevant. There was no significant difference in the amount of rectal filling and rectal air pockets between the treatment arms. Magnesium oxide is not effective in reducing the interfraction prostate motion or the amount of rectal filling and rectal gas during external-beam radiotherapy. Therefore, magnesium oxide is not recommended in clinical practice for these purposes. (orig.) [German] Ziel der Studie war es, zu untersuchen, ob Magnesiumoxid die interfraktionaere Bewegung und die rektale Fuellung sowie rektales Gas reduziert, was die Position der Prostata waehrend der Strahlentherapie bei Prostatakrebs beeinflusst. Von Dezember 2008 bis Februar 2010 haben 92 Prostatakrebspatienten die intensitaetsmodulierte Strahlentherapie (IMRT) mit bezugsmarkenbasierter Positionsverifikation erhalten (77 Gy in 35 Fraktionen). Sie wurden waehrend

  6. Scratch resistance and localised damage characteristics of polymer surfaces - a review

    Energy Technology Data Exchange (ETDEWEB)

    Briscoe, B.J. [Department of Chemical Engineering and Chemical Technology, Imperial College, London SW7 2BY (United Kingdom); Sinha, S.K. [Department of Mechanical Engineering, National University of Singapore (Singapore)

    2003-11-01

    The ''Scratch Test'' is, arguably, the earliest and amongst the now most widely used techniques for evaluating a wide range of surface mechanical properties. Some of the areas where this test has been successfully used in the engineering field, both by research and industry, include the determination of the relative hardness of materials, characterizations of coatings, paints and thin-films, modeling of the wear of materials and the estimation of different material deformation characteristics when subjected to hard asperity damage. In this paper we have reviewed the ''state-of-the-art'' in the scratch method for polymeric materials. The paper provides some important theoretical models that have been developed in the field of scratching for material property characterizations. Results from different types of scratch tests (macro, micro and nano scales) on a range of polymeric materials are presented with critical discussion on the usefulness of each result. Finally, various areas for further research in scratching of polymer surfaces have been identified. (Abstract Copyright [2003], Wiley Periodicals, Inc.) [German] Der ''Ritztest'' ist wohl das aelteste und mit am meisten verwendete Verfahren zur Beurteilung von oberflaechenmechanischen Eigenschaften. Zu den technischen Bereichen, in denen dieser Test sowohl in der Forschung als auch in der Industrie erfolgreich Anwendung gefunden hat, zaehlen die Bestimmung der relativen Materialhaerte, die Charakterisierung von Beschichtungen, Lackierungen und Duennschichten, die Modellierung des Werkstoffverschleisses sowie die Abschaetzung verschiedener Werkstoffverformungsparameter bei Beanspruchung durch harte Rauheitsspitzen. Der vorliegende Bericht beschreibt den gegenwaertigen Stand der Anwendung des Ritzverfahrens fuer polymere Materialien. Er enthaelt wichtige theoretische Modelle, die fuer die Anwendung des Ritzens zur Charakterisierung von

  7. The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling.

    Directory of Open Access Journals (Sweden)

    Christiane Desel

    Full Text Available Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB, the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM, is a potent adjuvant inducing strong Th1 and Th17 immune responses. We previously identified the C-type lectin Mincle as receptor for these glycolipids that triggers the FcRγ-Syk-Card9 pathway for APC activation and adjuvanticity. Interestingly, in vivo data revealed that the adjuvant effect was not solely Mincle-dependent but also required MyD88. Therefore, we dissected which MyD88-dependent pathways are essential for successful immunization with a tuberculosis subunit vaccine. We show here that antigen-specific Th1/Th17 immune responses required IL-1 receptor-mediated signals independent of IL-18 and IL-33-signaling. ASC-deficient mice had impaired IL-17 but intact IFNγ responses, indicating partial independence of TDB adjuvanticity from inflammasome activation. Our data suggest that the glycolipid adjuvant TDB triggers Mincle-dependent IL-1 production to induce MyD88-dependent Th1/Th17 responses in vivo.

  8. Strong Antibody Responses Induced by Protein Antigens Conjugated onto the Surface of Lecithin-Based Nanoparticles

    Science.gov (United States)

    Sloat, Brian R.; Sandoval, Michael A.; Hau, Andrew M.; He, Yongqun; Cui, Zhengrong

    2009-01-01

    An accumulation of research over the years has demonstrated the utility of nanoparticles as antigen carriers with adjuvant activity. Herein we defined the adjuvanticity of a novel lecithin-based nanoparticle engineered from emulsions. The nanoparticles were spheres of around 200 nm. Model protein antigens, bovine serum albumin (BSA) or Bacillus anthracis protective antigen (PA) protein, were covalently conjugated onto the nanoparticles. Mice immunized with the BSA-conjugated nanoparticles developed strong anti-BSA antibody responses comparable to that induced by BSA adjuvanted with incomplete Freund's adjuvant and 6.5-fold stronger than that induced by BSA adsorbed onto aluminum hydroxide. Immunization of mice with the PA-conjugated nanoparticles elicited a quick, strong, and durable anti-PA antibody response that afforded protection of the mice against a lethal dose of anthrax lethal toxin challenge. The potent adjuvanticity of the nanoparticles was likely due to their ability to move the antigens into local draining lymph nodes, to enhance the uptake of the antigens by antigen-presenting cells (APCs), and to activate APCs. This novel nanoparticle system has the potential to serve as a universal protein-based vaccine carrier capable of inducing strong immune responses. PMID:19729045

  9. Influência da temperatura de secagem e da concentração de Aerosil®200 nas características dos extratos secos por aspersão da Schinus terebinthifolius Raddi (Anacardiaceae

    Directory of Open Access Journals (Sweden)

    E.A.F. Vasconcelos

    Full Text Available A Schinus terebinthifolius Raddi é muito usada na medicina popular e atualmente como fitomedicamento pelas propriedades antimicrobiana, cicatrizante e antiinflamatória. O objetivo deste trabalho foi avaliar a influência da temperatura de entrada e a concentração de Aerosil®200 nas características de extratos secos por aspersão da Schinus terebinthifolius Raddi. Os extratos preparados com etanol 70 °GL foram secos em Mini-spray dryer, Buchi B191, com adição do adjuvante tecnológico numa proporção de 20:80; 25:75 e 30:70 (p/p Aerosil®200: resíduo seco, variando a temperatura de entrada de 120 °C a 160 °C. A umidade residual, o rendimento final do produto e o aumento da massa frente à umidade relativa controlada de 90 % foram usados como critério de avaliação. A análise de superfície de resposta revelou que à medida que a temperatura e a concentração de Aerosil aumentam, diminui a umidade residual dos extratos, bem como sua higroscopicidade. As melhores condições de secagem foram a temperatura de entrada de 140 °C e 30 % do adjuvante, resultando em rendimento acima de 80 %.

  10. Gaming

    CERN Document Server

    Duke, Richard D

    2014-01-01

    Als Richard Duke sein Buch ""Gaming: The Future's Language"" 1974 veröffentlichte, war er ein Pionier für die Entwicklung und Anwendung von Planspielen in Politik, Strategieentwicklung und Management. Das Buch wurde zu einem viel zitierten Standardwerk. 2014 feiert die von Richard D. Duke gegründete International Simulation and Gaming Association (ISAGA) ihr 45-jähriges Bestehen. Gleichzeitig legt Richard D. Duke eine überarbeitete Auflage seines Klassikers vor.   Inhaltsverzeichnis TABLE OF CONTENTSAcknowledgments Preface SECTION I1. The ProblemSECTION II2. Modes of Human Communication3. Mode

  11. Die Entwicklung des Eigentums- und Gesellschaftsrechts in Estland / Ilmar Selge

    Index Scriptorium Estoniae

    Selge, Ilmar, 1954-

    1992-01-01

    Õigusaktide tõlked: ROW nr. 6, lk. 181-190 (tlk. Ilmar Selge) - Gesetz der Republik Estland über die Grundlagen der Eigentumsreform ; Beschluss des Obersten Rates der Republik Estland über die Anwendung des Gesetzes über die Grundlagen der Eigentumsreform ; Bodenreformgesetz der Republik Estland ; Beschluss des Obersten Rates der Republik Estland über das Inkrafttreten des Bodenreformgesetz der Republik Estland. ROW nr. 10, lk. 307-310 (tlk. Ilmar Selge) - Gesetz der Republik Estland über ausländische Investitionen ; Unternehmenseinkommensteuergesetz (Auszug)

  12. Analyzing different HPCI operation modes simulated with ATHLET-CD regarding possible core degradation phenomena in Fukushima-Daiichi unit 3

    Energy Technology Data Exchange (ETDEWEB)

    Bratfisch, Christoph; Koch, Marco K. [Ruhr-Univ. Bochum (Germany). Reactor Simulation and Safety Group

    2017-02-15

    For extented application and analyses of the severe accident code ATHLET-CD, the course of the invessel accident in Unit 3 of Fukushima-Daiichi is simulated in the frame of the research project SUBA as a part of the BMBF sponsored collaborative project WASA-BOSS (Weiterentwicklung und Anwendung von Severe Accident Codes - Bewertung und Optimierung von Stoerfallmassnahmen). Investigations, carried out by TEPCO, had shown that the High-Pressure Coolant Injection system (HPCI) might have stopped earlier than expected. A parameter variation was performed to analyze the impact of the tripped HPCI injection regarding the thermohydraulic behaviour as well as the core degradation phenomena.

  13. Die Grundlagen der Fernsehtechnik: Systemtheorie und Technik der Bildübertragung

    Science.gov (United States)

    Mahler, Gerhard

    Umfassende Einführung in die Grundlagen der Bewegtbild-Übertragung von den Anfängen bis zum heutigen Stand des digitalen Fernsehens mit einer aus der Praxis entstandenen systemtheoretischen Analyse. Die kompakte und anschaulich bebilderte Darstellung mit elementaren mathematischen Beschreibungen macht es dem Leser leicht, sich in die Bildübertragungstechnik einzuarbeiten. Thematische Einheiten erweitern den Wissensstoff - u.a. zu den Themen visuelle Wahrnehmung, mehrdimensionale Signaldarstellung, Farbmetrik, Digitalisierung, Elektronenoptik - und zeigen deren Anwendung auf die elektronische Bildübertragung.

  14. Survey of legislation applicable in Germany for implementation of the EC Directive on environmental audits; Ueberblick ueber die in Deutschland fuer die Ausfuehrung der EG-Umwelt-Audit-Verordnung geltenden Rechtsvorschriften

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    The brochure presents a comprehensive survey of the relevant legislation applicable in Germany to implementation of the EC Directive on environmental auditing. Readers interested in performing such auditing at one glance will find in this compiulation all relevant laws and regulations in full text that are to be observed for implementation of this novel environmental auditing instrument. (orig./RHM) [Deutsch] Diese Broschuere vermittelt einen umfassenden Ueberblick ueber die in Deutschland fuer die Ausfuehrung der EG-Umwelt-Audit-Verordnung geltenden Rechtsvorschriften. Damit wird fuer alle Interessenten ein rascher Zugriff auf die Rechtstexte, die zur praktischen Anwendung des neuartigen Umwelt-Audit-Instruments notwendig sind, ermoeglicht. (orig./RHM)

  15. Optimization of environment compatible analysis methods for mineral hydrocarbons in the soil; Optimierung umweltvertraeglicher Analysenverfahren fuer Mineraloelkohlenwasserstoffe im Boden

    Energy Technology Data Exchange (ETDEWEB)

    Flachowsky, J.; Borsdorf, H. [eds.] [UFZ - Umweltforschungszentrum Leipzig-Halle GmbH, Leipzig (Germany); Loehmannsroeben, H.G.; Roch, T. [Erlangen-Nuernberg Univ., Erlangen (Germany); Leopom, P. [Umweltbundesamt, Berlin (Germany); Reimers, C. [Technische Univ. Hamburg-Harburg, Hamburg (Germany); Matz, G.; Kuebler, J. [MOBILAB GmbH, Hamburg (Germany); Christall, B. [SOFIA GmbH, Berlin (Germany); Hahn, M.; Matschiner, H. [Elektrochemie Halle GmbH (Germany); Baermann, A. [Dr. Baermann und Partner Mikroanalytik, Hamburg (Germany)

    1997-12-31

    This paper describes several analytical methods for the quantitative chemical analysis of mineral oil hydrocarbons in soils. The measuring methods are investigated on accuracy, errors, sample preparation methods, analysis of reference materials and real materials. (SR) [Deutsch] Mit dieser Schrift praesentiert die Deutsche Bundesstiftung Umwelt der Oeffentlichkeit Ergebnisse zu alternativen umweltvertraeglichen Bestimmungsmethoden fuer Mineraloelkohlenwasserstoffe in Boeden. Es war in erster Linie das Ziel aller beteiligten Forscher und Entwickler, die heute noch in der Anwendung befindliche Vorschrift nach DIN 38409 H18 zur Analytik von Mineraloelkohlenwasserstoffen durch eine sowohl umweltfreundliche als auch insgesamt aussagekraeftige Methode zu substituieren. (orig.)

  16. 'Subjektives' und 'objektives' Wissen in der audiologischen Diagnose

    DEFF Research Database (Denmark)

    Egbert, Maria

    sozial-psychologischen Barrieren (z.B. Stigma) die Interaktion zwischen Audiologen und Patienten selten erfolgreich verläuft. Ein Hauptproblem liegt darin, die 'objektive' Hördiagnose, (erstellt durch ein Audiogramm) in Zusammenhang zu bringen mit den 'subjektiven' Hörbeschreibungen des Patienten. Da der...... Audiologe sowohl auf die objektive als auch auf die subjektive Darstellung angewiesen ist, widmet sich diese Studie anhand von authentischen Videoaufnahmen diesen Diskrepanzen. Als methodischer Rahmen für die Anwendung der Ergebnisse werden die Ansätze "User-Centred Design" und "Social Innovation...

  17. Die biene und ihre produkte in der kunst und im alltagsleben (Fruhchristliche und byzantinische Zeit

    Directory of Open Access Journals (Sweden)

    Liveri Angeliki

    2010-01-01

    Full Text Available Die vorliegende Arbeit ist in zwei Teile geteilt: den kunst- und kulturhistorischen Teil. Im ersten Teil werden Darstellungen uber Bienen Bienenzucht, Honig und Wachs seit der fruhchristlichen bis zur spatbyzantinischen Zeit vorgefuhrt. Daher ist es als Beitrag in der "Ikonographie" der Biene wahrend dieser Zeit zu verstehen. Im kulturhistorischen Teil werden Informationen uber die Bienenzucht, den Handel mit Honig und Wachs sowie ihre vielfaltige Anwendung von der byzantinischen Gesellschaft an Hand der primaren Quellen, des Standes der Forschung und der archaologischen Funden erwahnt. Damit ist erwunscht ein moglichst gutes Bild der byzantinischen Bienenzucht wieder zu geben und die Nutzung der Bienenprodukte in Byzanz anschaulich zu machen.

  18. Haftung des "Director" einer englischen "Limited" gemäß § 64 GmbHG

    DEFF Research Database (Denmark)

    Ringe, Georg

    2016-01-01

    Für die Frage, ob und inwiefern auf EU-Auslandsgesellschaften inländisches Insolvenz- bzw. Gläubigerschutzrecht angewandt werden kann, differenziert der EuGH in seiner Entscheidung zwischen Vorschriften, die die Gründung der Gesellschaft und solchen, welche die spätere Tätigkeit betreffen. Wolf-G......-Georg Ringe (JZ 2016, 573) untersucht die Konsequenzen einer solchen Differenzierung und widerspricht dem Ergebnis des EuGH, der zur Anwendung des (insolvenzrechtlich qualifizierten) § 64 GmbHG im Fall einer englischen Limited kommt....

  19. Advances in radiographic NDI of pipe systems; Fortschritte bei der Durchstrahlungspruefung von Rohrleitungssystemen

    Energy Technology Data Exchange (ETDEWEB)

    Morgner, W. [NSQ HAUK, Ludwigshafen (Germany); Hauk, T. [NSQ HAUK, Ludwigshafen (Germany); Tschachlov, V. [NSQ HAUK, Tomsk (Russian Federation)

    1995-12-31

    The paper discusses the application of a small-sized betatron and its operational parameters, and its uses for very small angle tomography of medium-filled pipes or a thick weld. Other aspects discussed are the handling of large numbers of X-ray images by means of an X-ray manipulator, film digitalization, and data management of imaging data. (orig./MM) [Deutsch] Dieser Beitrag behandelt die Anwendung eines Kleinbetatrons und seiner Leistungsparameter, damit durchgefuehrte Durchstrahlungspruefungen an mediumgefuellten Rohren und eine an einer dicken Schweissnaht realisierte Wenigwinkeltomographie. Bezueglich der Beherrschung einer Grosszahl von Roentgenaufnahmen wird ueber einen Roentgenmanipulator, die Filmdigitalisierung und das Datenmanagement von Bilddaten berichtet. (orig./MM)

  20. Graded thermal insulation layer systems; Gradierte Waermedaemmschichtsysteme

    Energy Technology Data Exchange (ETDEWEB)

    Leushake, U.; Krell, T. [Deutsche Forschungsanstalt fuer Luft- und Raumfahrt e.V. (DLR), Koeln (Germany). Inst. fuer Werkstoff-Forschung

    1996-12-31

    Graded thermal insulation systems reduce local stresses between two layers. Grading usually involves a concentration variation in a second phase but may also involve variations of the microstructure or chemical composition. The contribution discusses the application of this technique for thermal protection of turbine blades in aircraft propulsion systems. [Deutsch] Mit Hilfe gradierter Waermeschichtsysteme ist es moeglich die lokalen Spannungen zwischen zwei Schichten zu verringern. Die Gradierung umfasst meistens eine Variation des Gehaltes einer zweiten Phase, kann aber auch die Variation der Mikrostruktur oder der chemischen Zusammensetzung beinhalten. In diesem Beitrag wird auf die Anwendung als thermischer Schutz von Turbinenschaufeln fuer Flugtriebwerke eingegangen.

  1. Wässrige Nanosuspensionen zur pulmonalen Applikation

    OpenAIRE

    Scherließ, Holger

    2008-01-01

    Im Rahmen der vorliegenden Arbeit wurde die Entwicklung einer Nanosuspensionsformulierung zur inhalativen Anwendung mit dem schwerlöslichen Antimykotikum Itraconazol untersucht. Viele der neu entwickelten pharmazeutischen Wirkstoffe sind nach der Arzneibuchdefinition als schwerlöslich, sehr schwer löslich oder gar praktisch unlöslich einzuteilen. Das bedingt in der Praxis häufig Probleme in der Bioverfügbarkeit und stellt eine große Herausforderung für die Galenik dar. Die Herstellung der Nan...

  2. Local Dynamic Map als modulares Software Framework für Fahrerassistenzsysteme

    Science.gov (United States)

    Reisdorf, P.; Auerswald, A.; Wanielik, G.

    2015-11-01

    Moderne Fahrerassistenzsysteme basieren auf der Verarbeitung von Informationen, welche durch die Umfeldwahrnehmung mit unterschiedlicher Sensorik erfolgt. Neben den Informationen aus dem eigenen Fahrzeug ergeben sich durch unterschiedliche Kommunikationsmöglichkeiten (Car2Car, Car2X,...) erweiterte Umfeldwahrnehmungen (siehe Abb. 1). Diese Daten gilt es aufbereitet und zielorientiert einer Anwendung zur Verfügung zu stellen, was mit Hilfe einer Local Dynamic Map (LDM) erfüllt werden kann. Die vorliegende Veröffentlichung beschreibt den Aufbau, Verwendungszweck und Eigenschaften einer entwickelten LDM und geht auf einige Applikationen ein, die mit Hilfe dieser realisiert wurden.

  3. Rückstandsanalytische Untersuchungen für eine aktualisierte Bewertung des Einsatzes hormonal wirksamer Leistungsförderer in der Tiermast

    OpenAIRE

    Lange, Iris Gudrun

    2005-01-01

    Bei der Anwendung hormonal wirksamer Leistungsförderer in der Tiermast in Form von Implantationspräparaten ist die Einhaltung der "Guten Veterinärpraxis" unabdingbar. Gelangen Implantationsstellen in die Nahrungskette, können ganze Chargen von Fleischprodukten kontaminiert werden. Das höchste Gefährdungspotential geht dabei von Trenbolonacetatpräparaten aus, gefolgt von Östradiol bzw. Östradiolbenzoat, Testosteronpropionat und Progesteron. Eine Evaluierung von Zeranol war diesbezüglich im Rah...

  4. Solar-aided air conditioning through sorption. Final report. Phase 2; Solar unterstuetzte Klimatisierung ueber Sorption. Endbericht zur Phase 2

    Energy Technology Data Exchange (ETDEWEB)

    Laevemann, E; Kessling, W; Peltzer, M

    1996-09-24

    The present article reports on possibilities of using solar energy for cooling buildings. It contains the following chapters: Current state of research and development; room air conditioning; planning and results of the studies; theory; experimental studies on the sorption dehumidifier; development of exchange surfaces; development of solution distributors; cooling of exchange surfaces; construction of a sorption dehumidifier. (HW) [Deutsch] Die Arbeit berichtet ueber Moeglichkeiten der Anwendung von Solarenergie zur Kuehlung von Gebaeuden. Die Arbeit enthaelt folgende Kapitel: - Stand der Forschung und Entwicklung - Raumklimatisierung - Planung und Ergebnis der Untersuchungen - Theorie - Experimentelle Untersuchungen am Sorptionsentfeuchter - Entwicklung von Austauschflaechen - Entwicklung von Loesungsverteilern - Kuehlung von Austauschflaechen - Konstruktion eines Sorptionsentfeuchters. (HW)

  5. Einfluss der Etch-and-Rinse-Technik auf Adper Easy Bond

    OpenAIRE

    Kunstmann, Thorsten

    2011-01-01

    Ziel der vorliegenden Studie war es die Auswirkungen der Etch-and-Rinse-Technik auf die Randqualität von Kompositfüllungen bei Anwendung des selbstätzenden Bondingsystems Adper Easy Bond zu untersuchen. An 64 extrahierten menschlichen Molaren wurden tiefe Klasse-II-Kavitäten präpariert, deren approximale Begrenzung unterhalb der Schmelz-Zement-Grenze lag. Diese wurden in acht Gruppen aufgeteilt, jeweils mit 8 Zähnen pro Gruppe, und mittels verschiedener Bonding-Techniken mit Kompositfüllungen...

  6. Speziation von Gadolinium-MRT-Kontrastmitteln in Umweltmatrizes

    OpenAIRE

    Lindner, Uwe

    2017-01-01

    Gd-Kontrastmittel werden in der Medizin für die Magnetresonanztomographie (MRT) benötigt, um einen besseren Bildkontrast zu erzielen. Nach der Anwendung gelangen diese Arzneimittel über das Abwasser in die Klärwerke und von dort in die jeweiligen anliegenden Oberflächengewässer. Somit wird es notwendig, den Verbleib der Gd-MRT-Kontrastmittel in der Umwelt zu verfolgen und aufzuklären. In dieser Arbeit werden für die Analyse von Umweltproben Methoden zur Speziesanalytik von Gd-Kontrastmitteln ...

  7. Transonic and Supersonic Phenomena in Turbomachines: Proceedings of the Propulsion and Energetics (68th)(B) Specialists’ Meeting Held in Munich, Germany on 10-12 September 1986

    Science.gov (United States)

    1987-03-01

    Saiatain a tbeavodyutaaiclly equivalent ialot caat41tiaa a separate amalyots was 2048 3 � &C 0.5 0.0 0.5. 1.0 .5 oz. 0.0 1.5 rigux x1Gaato im n w...Zeitschrittverfahren VDI -Forschungsheft 686, S. 5-24 VDI -Verlag, DUsseldorf (1978) [3] Kiock, R. The Transonic Flow Through a Plane Turbine Cascade Lehthaus, F. as...Amecke, J. Anwendung der tranasonischen Ahnlichkeitsregel auf die Str~mung durch ebene Schaufelgitter VDI -Forachungsheft 540, S. 16-28 VDI -Verlag

  8. Nothing stays ever the same. Stationary fuel cells, the revolution in domestic and industrial power supply; Nichts bleibt, wie es ist.... Revolution der Energieversorgung in der Haustechnik und Industrie mit stationaeren Brennstoffzellen

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2001-02-01

    Helmut Kaiser Unternehmensberatung (HKU), an organisation that claims to be a leading consultant in the fields of environmental engineering, energy engineering, health and life science, investigated the current trends in stationary fuel cell applications world-wide. The study covers market and technology forecasts and an analysis of the competitive standing of suppliers world-wide. [German] Die Helmut Kaiser Unternehmensberatung (HKU), nach eigenen Angaben weltweit eines der fuehrenden Forschungs- und Beratungsunternehmen in der Umwelt-, Energietechnik sowie Gesundheit (Life Science), untersuchte in einer neuen Studie die Entwicklung der Brennstoffzellen in der stationaeren Anwendung weltweit. Die Studie umfasst Markt- und Technologieprognosen sowie eine Wettbewerbsanalyse der Anbieter weltweit. (orig.)

  9. Expression of Ku70 predicts results of radiotherapy in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Tomokazu; Someya, Masanori; Hori, Masakazu; Nakata, Kensei; Kitagawa, Mio; Tsuchiya, Takaaki; Sakata, Koh-ichi [Sapporo Medical University School of medicine, Department of Radiology, Chuo-ku, Sapporo, Hokkaido (Japan); Matsumoto, Yoshihisa [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Meguro-ku, Tokyo (Japan); Nojima, Masanori [The University of Tokyo, The Institute of Medical Science Hospital, Minatoku, Tokyo (Japan); Masumori, Naoya [Sapporo Medical University School of medicine, Department of Urology, Chuo-ku, Sapporo, Hokkaido (Japan); Hasegawa, Tadashi [Sapporo Medical University School of medicine, Department of Surgical Pathology, Chuo-ku, Sapporo, Hokkaido (Japan)

    2017-01-15

    Strahlentherapie zu prognostizieren. Fuer eine bessere Vorhersagbarkeit eines Lokalrezidivs sind weitere Parameter zur Strahlenempfindlichkeit erforderlich. Wir untersuchten zwischen August 2007 und Oktober 2010 als Entwicklungskohorte 58 mit intensitaetsmodulierter Strahlentherapie (IMRT, 76 Gy) behandelte Patienten mit einem lokalisierten Prostataadenokarzinom sowie zwischen Maerz 2001 und Mai 2007 als Validierungskohorte 42 mit dreidimensionaler konformaler Strahlentherapie (3D-CRT) behandelte Patienten. Eine immunhistochemische Untersuchung der am nichthomologen Endjoining beteiligten Proteine wurde unter Verwendung von Biopsaten durchgefuehrt. Die Ku70-Expression wurde nicht mit verschiedenen klinischen Parametern korreliert, wie z. B. Gleason-Score und Risikostratifizierung nach D'Amico, und scheint daher einen unabhaengigen Prognosefaktor darzustellen. Der Vorhersagewert war fuer PSA-Rezidive nach Kombination von Gleason-Score und Ku70-Expression im Vergleich zum Gleason-Score allein deutlich besser. Bei Strahlentherapie und Androgendeprivationstherapie (ADT) zeigten Patienten mit Gleason-Score ≤7 oder niedriger Ku70-Expression keine Rezidive. Dagegen war bei einem Gleason-Score ≥8 und hoher Ku70-Expression die PSA-Rezidivrate hoch. Aehnliche Ergebnisse lieferte die Validierungskohorte. Die Behandlung mit 76 Gy und ADT kann bei Patienten mit Gleason-Score ≤7 oder niedriger Ku70-Expression wirksam sein, ist aber bei einem Gleason-Score ≥8 und hoher Ku70-Expression nicht ausreichend, so dass in diesen Faellen andere Behandlungsansaetze erforderlich sind. (orig.)

  10. Modulation of the toxicity of photons by non-conventional drugs

    International Nuclear Information System (INIS)

    Bohm, L.; Theron, T.; Serafin, A.; Verheye, F.

    1997-01-01

    The 3 drugs under investigation Pentoxifylline, Ouabain and Thalidomide are non-conventional in the sense that they have a low toxicity and do not damage DNA. Pentoxifylline reduces blood viscosity ad enhances peripheral blood flow. When combined with irradiation in a mouse rhabdomyosarcoma model we found markedly enhanced tumour growth delay and in cultured cells dose modifying factors for SF2 and alpha in the region of 1.2-1.7 (Strahlentherapie 1995;170:595-01). The drug also alters cell regulation by inhibiting the radiation induced G2/M block and suppressing control of DNA synthesis (Theron and Boehm, unpubl.). When Thalidomide was added in the absence of irradiation to the myelo-blastic cell line K-562 we found characteristic changes of cell morphology and cell surface markers suggesting differentiation and expression of a megacaryocytic lineage (Leukemia Research 1991;15:129-136). A summary of the current state of research is given. (authors)

  11. Combined external beam and intraluminal radiotherapy for irresectable Klatskin tumors

    Energy Technology Data Exchange (ETDEWEB)

    Schleicher, U.M. [Klinik fuer Strahlentherapie, Technische Hochschule Aachen (Germany); Staatz, G. [Klinik fuer Radiologische Diagnostik, Technische Hochschule Aachen (Germany); Alzen, G. [Klinik fuer Radiologische Diagnostik, Technische Hochschule Aachen (Germany); Abt. Kinderradiologie, Giessen Univ. (Germany); Andreopoulos, D. [Klinik fuer Strahlentherapie, Technische Hochschule Aachen (Germany); BOC Oncology Centre, Nikosia (Cyprus)

    2002-12-01

    Background: In most cases of proximal cholangiocarcinoma, curative surgery is not possible. Radiotherapy can be used for palliative treatment. We report our experience with combined external beam and intraluminal radiotherapy of advanced Klatskin's tumors. Patients and Methods: 30 patients were treated for extrahepatic proximal bile duct cancer. Our schedule consisted for external beam radiotherapy (median dose 30 Gy) and a high-dose-rate brachytherapy boost (median dose 40 Gy) delivered in four or five fractions, which could be applied completely in twelve of our patients. 15 patients in the brachytherapy and nine patients in the non-brachytherapy group received additional low-dose chemotherapy with 5-fluorouracil. Results: The brachytherapy boost dose improved the effect of external beam radiotherapy by increasing survival from a median of 3.9 months in the non-brachytherapy group to 9.1 months in the brachytherapy group. The effect was obvious in patients receiving a brachytherapy dose above 30 Gy, and in those without jaundice at the beginning of radiotherapy (p<0.05). Conclusions: The poor prognosis in patients with advanced Klatskin's tumors may be improved by combination therapy, with the role of brachytherapy and chemotherapy still to be defined. Our results suggest that patients without jaundice should be offered brachytherapy, and that a full dose of more than 30 Gy should be applied. (orig.) [German] Hintergrund: Bei den meisten Patienten mit proximalen Cholangiokarzinomen ist eine kurative Operation nicht mehr moeglich. Im Rahmen der Palliativbehandlung kann die Strahlentherapie eingesetzt werden. Wir berichten ueber unsere Erfahrungen mit der Kombination aus perkutaner und intraluminaler Strahlentherapie fortgeschrittener Klatskin-Tumoren. Patienten und Methode: 30 Patienten wurden wegen extrahepatischer proximaler Gallengangskarzinome behandelt. Unser Therapieschema umfasste eine perkutane Strahlentherapie (mediane Dosis: 30 Gy) sowie einen

  12. Predictors for occlusion of cerebral AVMs following radiation therapy. Radiation dose and prior embolization, but not Spetzler-Martin grade

    Energy Technology Data Exchange (ETDEWEB)

    Knippen, Stefan; Putz, Florian; Semrau, Sabine; Lambrecht, Ulrike; Knippen, Arzu; Fietkau, Rainer [Friedrich-Alexander-University Erlangen-Nuremberg, Department of Radiation Oncology, Erlangen (Germany); Buchfelder, Michael; Schlaffer, Sven [Friedrich-Alexander-University Erlangen-Nuremberg, Department of Neurosurgery, Erlangen (Germany); Struffert, Tobias [Friedrich-Alexander-University Erlangen-Nuremberg, Department of Neuroradiology, Erlangen (Germany)

    2017-03-15

    Intracranial arteriovenous malformations (AVMs) may show a harmful development. AVMs are treated by surgery, embolization, or radiation therapy. This study investigated obliteration rates and side effects in patients with AVMs treated by radiation therapy. A total of 40 cases treated between 2005 and 2013 were analyzed. Single-dose stereotactic radiosurgery (SRS) was received by 13 patients and 27 received hypofractionated stereotactic radiation therapy (HSRT). In 20 patients, endovascular embolization had been performed prior to irradiation and 24 patients (60 %) had a history of previous intracranial hemorrhage. Treatment resulted in complete obliteration (CO) in 23/40 cases and partial obliteration in 8/40. CO was achieved in 85 % of patients receiving SRS compared to 44 % of those receiving HSRT. In the HSRT group, a first indication of an influence of AVM volume on obliteration rate was found. Equivalent 2 Gy fraction doses (EQD2) >70 Gy showed an obliteration rate of 50 %. Prior embolization was significantly associated with a higher portion of CO (p = 0.032). Median latency period (24.2 vs. 26 months) until CO was similar in both groups (SRS vs. HSRT). The rate of intracranial hemorrhage in patients with no prior bleeding events was 0 %. Excellent obliteration rates were achieved by SRS. Consistent with the literature, this data analysis suggests that the results of HSRT are volume-dependent. Furthermore, regimens with EQD2 doses >70 Gy appear more likely to achieve obliteration than schemes with lower doses. The findings indicate that radiation therapy does not increase the risk of bleeding. Prior embolization may have a good prognostic impact. (orig.) [German] Intrakranielle arteriovenoese Malformationen (AVM) koennen einen komplikationsbehafteten Verlauf zeigen. AVMs sind mittels Operation, Embolisation oder Strahlentherapie behandelbar. Die Studie untersucht Obliterationsraten und Nebenwirkungen bestrahlter AVM-Patienten. Analysiert wurden 40 Faelle, die

  13. Radiotherapy in desmoid tumors. Treatment response, local control, and analysis of local failures

    Energy Technology Data Exchange (ETDEWEB)

    Santti, Kirsi; Beule, Annette; Tuomikoski, Laura; Jaeaeskelaeinen, Anna-Stina; Saarilahti, Kauko; Tarkkanen, Maija; Blomqvist, Carl [Helsinki University Hospital and University of Helsinki, Comprehensive Cancer Center, Helsinki (Finland); Roenty, Mikko [HUSLAB and University of Helsinki, Department of Pathology, Helsinki (Finland); Ihalainen, Hanna [Helsinki University Hospital and University of Helsinki, Department of Plastic Surgery, Helsinki (Finland)

    2017-04-15

    Desmoid tumors (aggressive fibromatosis) are rare soft tissue tumors which frequently recur after surgery. Desmoid tumors arise from musculoaponeurotic tissue in the extremities, head and neck, abdominal wall, or intra-abdominally. Our aim was to examine the outcome of radiotherapy of desmoid tumors in a single institution series. We evaluated 41 patients with desmoid tumors treated with 49 radiotherapies between 1987 and 2012. Radiologic images for response evaluation were reassessed and responses to treatment registered according to RECIST criteria 1.1. For patients with local failures radiation dose distribution was determined in each local failure volume using image co-registration. Recurrences were classified as in-target, marginal, or out-of-target. Prognostic factors for radiotherapy treatment failure were evaluated. Radiotherapy doses varied from 20-63 Gy (median 50 Gy) with a median fraction size of 2 Gy. The objective response rate to definitive radiotherapy was 55% (12/22 patients). Median time to response was 14 months. A statistically significant dose-response relation for definitive and postoperative radiotherapy was observed both in univariate (p-value 0.002) and in multivariate analysis (p-value 0.02) adjusted for potential confounding factors. Surgery before radiotherapy or surgical margin had no significant effect on time to progression. Nine of 11 (82%) local failures were classified as marginal and two of 11 (18%) in-target. None of the recurrences occurred totally out-of-target. Radiotherapy is a valuable option for treating desmoid tumors. Radiotherapy dose appears to be significantly associated to local control. (orig.) [German] Desmoide (aggressive Fibromatosen) sind seltene Weichteiltumore der muskulaeren Membranen von Kopf, Hals, Extremitaeten und Bauchwand. Ziel war es, die Wirksamkeit der Strahlentherapie bei aggressiver Fibromatose an einer einzelnen Klinik zu untersuchen. Ausgewertet wurden 41 Patienten mit aggressiver Fibromatose, die

  14. Magnetic resonance image-guided brachytherapy for cervical cancer. Prognostic factors for survival

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yeon-Joo; Kim, Joo-Young [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); National Cancer Center, Center for Uterine Cancer, Goyang (Korea, Republic of); Kim, Youngkyong; Lim, Young Kyung; Jeong, Jonghwi [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); Jeong, Chiyoung [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); University of Ulsan College of Medicine, Department of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of); Kim, Meyoung [National Cancer Center, Proton Therapy Center, Goyang (Korea, Republic of); Dongnam Inst. of Radiology and Medical Sciences, Research center, Busan (Korea, Republic of); Lim, Myong Cheol; Seo, Sang-Soo; Park, Sang-Yoon [National Cancer Center, Center for Uterine Cancer, Goyang (Korea, Republic of)

    2016-12-15

    The purpose of this work was to identify prognostic factors for survival after magnetic resonance image (MRI)-guided brachytherapy combined with external beam radiotherapy for cervical cancer. External beam radiotherapy of 45-50.4 Gy was delivered by either three-dimensional conformal radiotherapy or helical tomotherapy. Patients also received high-dose-rate MRI-guided brachytherapy of 5 Gy in 6 fractions. We analyzed 128 patients with International Federation of Gynecology and Obstetrics stage IB-IVB cervical cancer who underwent MRI-guided brachytherapy. Most patients (96 %) received concurrent chemotherapy. Pelvic lymph node metastases and para-aortic lymphadenopathies were found in 62 % and 14 % of patients, respectively. The median follow-up time was 44 months. Complete remission was achieved in 119 of 128 patients (93 %). The 5-year local recurrence-free, cancer-specific, and overall survival rates were 94, 89, and 85 %, respectively. Negative pelvic lymphadenopathy, gross tumor volume (GTV) dose covering 90 % of the target (GTV D90) of >110 Gy, and treatment duration ≤56 days were associated with better overall survival in univariate analyses. Multivariable analysis showed that GTV D90 of >110 Gy and treatment duration ≤56 days were possibly associated with overall survival with near-significant P-values of 0.062 and 0.073, respectively. The outcome of MRI-guided brachytherapy combined with external beam radiotherapy in patients with cervical cancer was excellent. GTV D90 of >110 Gy and treatment duration ≤56 days were potentially associated with overall survival. (orig.) [German] Ziel der Arbeit war es, prognostische Faktoren nach magnetresonanztomographisch (MRT-)gesteuerter Brachytherapie in Verbindung mit externer Strahlentherapie fuer Gebaermutterhalskrebs zu identifizieren. Externe Strahlentherapie von 45-50,4 Gy erfolgte entweder mittels dreidimensionaler konformaler Strahlentherapie oder helikaler Tomotherapie. Die Patientinnen erhielten auch

  15. INEL BNCT research program publications, 1993

    International Nuclear Information System (INIS)

    1994-05-01

    This document is a collection of the published reports describing research supporting the Idaho National Engineering Laboratory Boron Neutron Capture Therapy Research Program for calendar year 1993. Contributions from the principal investigators are included, covering chemistry (pituitary tumor studies, boron drug development including liposomes, lipoproteins, and carboranylalanine derivatives), pharmacology (murine screenings, toxicity testing, ICP-AES analysis of biological samples), physics (radiation dosimetry software, neutron beam and filter design, neutron beam measurement dosimetry), and radiation biology (tissue and efficacy studies of small and large animal models). These reports have previously appeared in the book: Advances in Neutron Capture Therapy, edited by A. H. Soloway, R. F. Barth, D. E. Carpenter, Plenum Press, 1993. Reports have also appeared in three journals: Angewandte Chemie, Strahlentherapie und Onkologie, and Nuclear Science and Engineering. This individual papers have been indexed separately elsewhere

  16. Definition of stereotactic body radiotherapy. Principles and practice for the treatment of stage I non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Guckenberger, M.; Sauer, O. [University of Wuerzburg, Department of Radiation Oncology, Wuerzburg (Germany); Andratschke, N. [University of Rostock, Department of Radiotherapy and Radiation Oncology, Rostock (Germany); Alheit, H. [Distler Radiation Oncology, Bautzen/Pirna (Germany); Holy, R. [RWTH