WorldWideScience

Sample records for anus cardiac anomalies

  1. Ectopic anus with barrel gun perineum rare type of anorectal anomaly

    OpenAIRE

    Chamaria, Komal; Shetty, Roshan

    2013-01-01

    Perineal ectopic anus in female infants is not a very uncommon congenital anorectal anomaly with opening into the low vaginal or vulvar region. However, ectopic anus with barrel gun perineum is a less common variety. Patients generally present with frequent history of constipation, but may seek medical help for just aesthetic reasons. We present here one such case of an asymptomatic seven years old female with the rare form of anterior ectopic anus with barrel gun perineum without any fistulo...

  2. Congenital funnel anus in children: associated anomalies, surgical management and outcome.

    Science.gov (United States)

    Suomalainen, Anna; Wester, Tomas; Koivusalo, Antti; Rintala, Risto J; Pakarinen, Mikko P

    2007-12-01

    Funnel anus (FA) is a rare and distinct type of anorectal malformation characterized by a skin-lined deep anal funnel, missing transitional epithelium and stenosis secondary to fibrotic internal sphincter. We aimed to characterize associated anomalies, surgical management and outcome of children with FA. The hospital records of 11 consecutive children (7 boys) treated for FA between 1992 and 2006 were screened. The collected data included the type of anorectal malformation, surgical management, associated anomalies, results of diagnostic investigations and outcome. Only one patient was free of any associated malformation. Six patients had a complete Currarino syndrome. Seven patients had a hemisacrum (scimitar) and tethered cord was present in two cases. Six patients underwent excision of a benign presacral teratoma. Anal stenosis associated with FA was managed by serial dilatations. Subsequent resection of the megarectosigmoid secondary to refractory constipation was performed on five occasions. Three patients underwent coloanal pull-through for Hirschsprung's disease (HD). The level of aganglionosis was at the rectosigmoid junction in two cases and low in the rectum in one. One additional patient had hypoganglionosis. Of the three patients with HD two also had Down's syndrome. After median follow-up of 6.5 (0.3-13.5) years four patients have normal bowel function and four suffer from soiling. Two patients with HD and Down's syndrome and one patient with an undefined syndrome are fecally incontinent. Associated anomalies are common and diverse in children with FA. Pelvic MRI, sacral radiography, evaluation of the urinary tract and rectal biopsies are recommended as routine investigations in cases of FA. Surgical care of these patients is demanding and should be confined to dedicated centers. PMID:17929036

  3. IS CONSANGUINEOUS MARRIAGE RESPONSIBLE FOR CONGENITAL CARDIAC AND EXTRA-CARDIAC ANOMALIES?

    OpenAIRE

    Nutan Nalini; Sudha

    2016-01-01

    BACKGROUND This article is about the stillbirth in which we found significant numbers of cardiac as well as extracardiac defects, in combination or separately. In this article, we would like to emphasize the anomalies found in consanguineous marriages. AIM To correlate the prevalence of cardiac as well as extracardiac anomalies in consanguineous marriages. Especially, here we would like to focus on the cardiac lesions. MATERIAL AND METHOD The study was ca...

  4. Cryptorchidism in boys with imperforate anus

    DEFF Research Database (Denmark)

    Cortes, Dina; Thorup, J M; Nielsen, Ole Henrik;

    1995-01-01

    In a retrospective study of the case reports of 136 boys who were operated on for an imperforate anus and who survived at least 18 months, cryptorchidism was the most common associated anomaly, involving 26 cases (19%). The higher the level of the anorectal malformations, the higher was the...

  5. MRI anatomy of anteriorly displaced anus: what obstructs defecation?

    Energy Technology Data Exchange (ETDEWEB)

    AbouZeid, Amr Abdelhamid [Ain-Shams University, Department of Pediatric Surgery, Cairo (Egypt); Mohammad, Shaimaa Abdelsattar; Khairy, Khaled Talaat [Ain-Shams University, Department of Radiodiagnosis, Cairo (Egypt)

    2014-07-15

    Anteriorly displaced anus is an anomaly that is debated with regard to its nomenclature, diagnosis and management. To describe MRI anatomy of the anal canal in children with anteriorly displaced anus and its impact on the process of defecation. We prospectively examined ten children (7 girls, 3 boys; age range 7 months to 8 years, mean 3 years) with anteriorly displaced anus between August 2009 and April 2012. Noncontrast MRI examinations were performed on a 1.5-T magnet. T1- and T2-weighted turbo spin-echo images were acquired in axial, sagittal and coronal planes of the pelvis. The anorectal angle and the relative hiatal distance were measured in mid-sagittal images, and compared with those of a control group using the Mann-Whitney test. In children with anteriorly displaced anus, no anatomical abnormality was depicted at the level of the proximal anal canal. However, the distal anal canal was displaced anteriorly, running out its external muscle cuff, which remained un-displaced at the usual site of the anus. This changes the orientation of the central axis of the anal canal by passing across instead of along the fibers of the longitudinal muscle coat. Children with anteriorly displaced anus had a more obtuse anorectal angle (mean 112.1 ), which was significantly greater than that of the control group (mean 86.2 ). MRI is a valuable tool in studying the anatomy of the anal canal in children with anteriorly displaced anus. The abnormal orientation of the longitudinal muscle across the anal canal can explain the obstructed defecation in these children. Based on this study, it might be of interest to use MRI in studying equivocal cases and children with unexplained constipation. (orig.)

  6. An ECG Monitoring System For Prediction Of Cardiac Anomalies Using WBAN

    OpenAIRE

    Hadjem, Medina; Salem, Osman; Naït-Abdesselam, Farid

    2014-01-01

    International audience Cardiovascular diseases (CVD) are known to be the most widespread causes to death. Therefore, detecting earlier signs of cardiac anomalies is of prominent importance to ease the treatment of any cardiac complication or take appropriate actions. Electrocardiogram (ECG) is used by doctors as an important diagnosis tool and in most cases, it's recorded and analyzed at hospital after the appearance of first symptoms or recorded by patients using a device named holter ECG...

  7. Multiple cardiac anomalies in a family of Saluki dogs.

    Science.gov (United States)

    Ogburn, P N; Peterson, M; Jeraj, K

    1981-07-01

    Clinical studies of a family of Saluki dogs demonstrated a spectrum of cardiac malformations, which ranged from mild thickening of a pulmonic valve leaflet to a complex condition composed of tricuspid valve insufficiency, pulmonic stenosis, patent ductus arteriosus, and mitral valve insufficiency. All affected dogs had patent ductus arteriosus or ductus diverticulum, which is an incomplete or atypical form of patent ductus arteriosus. The clinical findings varied with the type of cardiac lesion(s) found. Pedigree evaluation suggested a genetic cause, though environmental factors could not be excluded. PMID:7251462

  8. The developing role of fetal magnetic resonance imaging in the diagnosis of congenital cardiac anomalies: A systematic review

    Directory of Open Access Journals (Sweden)

    Rohit S Loomba

    2011-01-01

    Full Text Available Advances in the fetal magnetic resonance imaging (MRI over the last few years have resulted in the exploring the use of fetal MRI to detect congenital cardiac anomalies. Early detection of congenital cardiac anomalies can help more appropriately manage the infant′s delivery and neonatal management. MRI offers anatomical and functional studies and is a safe adjunct that can help more fully understand a fetus′ cardiac anatomy. It is important for the obstetricians and pediatric cardiologists to be aware of the recent advancements in fetal MRI and it`s potential utility in diagnosing congenital cardiac anomalies.

  9. The developing role of fetal magnetic resonance imaging in the diagnosis of congenital cardiac anomalies: A systematic review

    International Nuclear Information System (INIS)

    Advances in the fetal magnetic resonance imaging (MRI) over the last few years have resulted in the exploring the use of fetal MRI to detect congenital cardiac anomalies. Early detection of congenital cardiac anomalies can help more appropriately manage the infant's delivery and neonatal management. MRI offers anatomical and functional studies and is a safe adjunct that can help more fully understand a fetus' cardiac anatomy. It is important for the obstetricians and pediatric cardiologists to be aware of the recent advancements in fetal MRI and it's potential utility in diagnosing congenital cardiac anomalies

  10. An autosomal recessive syndrome of cleft palate, cardiac defect, genital anomalies, and ectrodactyly (CCGE).

    OpenAIRE

    Giannotti, A; Digilio, M C; Mingarelli, R; Dallapiccola, B.

    1995-01-01

    We report a brother and sister affected by a constellation of malformations, including cleft palate, cardiac defect, genital anomalies, and ectrodactyly (CCGE). A similar association has been reported previously by Richieri-Costa and Orquizas in a male patient born to consanguineous parents. An autosomal recessive pattern of inheritance is proposed for this syndrome.

  11. Primary vesicoureteric reflux in neonates with imperforate anus.

    OpenAIRE

    Rickwood, A. M.; Spitz, L

    1980-01-01

    Cystography, performed in 26 out of a total of 33 consecutive neonates with imperforate anus, revealed primary vesicoureteric reflux in 12 cases. The reflux was usually pronounced, and was particularly common in females and in infants with urinary tract infections. The incidence of reflux was unrelated to the severity of the anorectal anomaly, and reflux was often demonstrated in patients in whom an intravenous pyelogram had shown an undilated upper renal tract.

  12. Pattern-based approach to fetal congenital cardiovascular anomalies using the transverse aortic arch view on prenatal cardiac MRI

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Su-Zhen; Zhu, Ming [Shanghai Jiaotong University School of Medicine, Department of Radiology, Shanghai Children' s Medical Center, Shanghai (China)

    2015-05-01

    Fetal echocardiography is the imaging modality of choice for prenatal diagnosis of congenital cardiovascular anomalies. However, echocardiography has limitations. Fetal cardiac magnetic resonance imaging (MRI) has the potential to complement US in detecting congenital cardiovascular anomalies. This article draws on our experience; it describes the transverse aortic arch view on fetal cardiac MRI and important clues on an abnormal transverse view at the level of the aortic arch to the diagnosis of fetal congenital cardiovascular anomalies. (orig.)

  13. Pattern-based approach to fetal congenital cardiovascular anomalies using the transverse aortic arch view on prenatal cardiac MRI

    International Nuclear Information System (INIS)

    Fetal echocardiography is the imaging modality of choice for prenatal diagnosis of congenital cardiovascular anomalies. However, echocardiography has limitations. Fetal cardiac magnetic resonance imaging (MRI) has the potential to complement US in detecting congenital cardiovascular anomalies. This article draws on our experience; it describes the transverse aortic arch view on fetal cardiac MRI and important clues on an abnormal transverse view at the level of the aortic arch to the diagnosis of fetal congenital cardiovascular anomalies. (orig.)

  14. Ebstein’s Anomaly, Left Ventricular Noncompaction, and Sudden Cardiac Death

    Directory of Open Access Journals (Sweden)

    Michael McGee

    2015-01-01

    Full Text Available Ebstein’s anomaly is a congenital disorder characterized by apical displacement of the septal leaflet of the tricuspid valve. Ebstein’s anomaly may be seen in association with other cardiac conditions, including patent foramen ovale, atrial septal defect, and left ventricular noncompaction (LVNC. LVNC is characterized by increased trabeculation within the left ventricular apex. Echocardiography is often used to diagnose LVNC; however, magnetic resonance (MR imaging offers superior characterization of the myocardium. We report a case of sudden cardiac death in a patient with Ebstein’s anomaly with unrecognized LVNC noted on post mortem examination with screening documenting the presence of LVNC in one of the patient’s twin sons.

  15. Atresia of the bilateral pulmonary veins: a rare and dismal anomaly identified on cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo; Park, Sang-Hyub; Koo, Hyun Jung; Cho, Young Hoon; Lee, Eunsol [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of)

    2014-08-15

    Imaging findings of bilateral pulmonary vein atresia have not been described. To describe cardiac CT findings and clinical outcomes of bilateral pulmonary vein atresia. Three newborns with bilateral pulmonary vein atresia were encountered at our institution during a period of 8 years. We evaluated prenatal echocardiographic findings, clinical presentations, postnatal echocardiographic findings, chest radiographic findings, cardiac CT findings and clinical outcomes. All newborns presented immediately after birth with severe cyanosis, respiratory distress and acidosis that were unresponsive to medical management. Prenatal and postnatal echocardiographic studies and chest radiography were misleading, inconclusive or nonspecific in making the diagnosis in these children; however cardiac CT clearly demonstrated atresia of the bilateral pulmonary veins with multiple small mediastinal collateral veins and pulmonary edema. Surgical treatments were not feasible for this anomaly. Their clinical outcomes were universally dismal and all infants died within 3 days. Cardiac CT provides an accurate diagnosis of bilateral pulmonary vein atresia and leads to prompt treatment decision in these children. (orig.)

  16. Atresia of the bilateral pulmonary veins: a rare and dismal anomaly identified on cardiac CT

    International Nuclear Information System (INIS)

    Imaging findings of bilateral pulmonary vein atresia have not been described. To describe cardiac CT findings and clinical outcomes of bilateral pulmonary vein atresia. Three newborns with bilateral pulmonary vein atresia were encountered at our institution during a period of 8 years. We evaluated prenatal echocardiographic findings, clinical presentations, postnatal echocardiographic findings, chest radiographic findings, cardiac CT findings and clinical outcomes. All newborns presented immediately after birth with severe cyanosis, respiratory distress and acidosis that were unresponsive to medical management. Prenatal and postnatal echocardiographic studies and chest radiography were misleading, inconclusive or nonspecific in making the diagnosis in these children; however cardiac CT clearly demonstrated atresia of the bilateral pulmonary veins with multiple small mediastinal collateral veins and pulmonary edema. Surgical treatments were not feasible for this anomaly. Their clinical outcomes were universally dismal and all infants died within 3 days. Cardiac CT provides an accurate diagnosis of bilateral pulmonary vein atresia and leads to prompt treatment decision in these children. (orig.)

  17. Perirectal mucocele after imperforate anus repair

    Energy Technology Data Exchange (ETDEWEB)

    Panicek, D.M.; Leeson, S.H.; Farrar, F.M.; Hitch, D.C.

    1987-01-01

    A large perirectal mucocele developed in a child over an 11-year period following repair of an imperforate anus. Renal failure and large bowel obstruction secondary to compression by the mass were the presenting symptoms. Computed tomographic evaluation of the pelvis was critical for preoperative assessment of this previously unreported complication of imperforate anus repair.

  18. Perirectal mucocele after imperforate anus repair

    International Nuclear Information System (INIS)

    A large perirectal mucocele developed in a child over an 11-year period following repair of an imperforate anus. Renal failure and large bowel obstruction secondary to compression by the mass were the presenting symptoms. Computed tomographic evaluation of the pelvis was critical for preoperative assessment of this previously unreported complication of imperforate anus repair. (orig.)

  19. Anomalies.

    Science.gov (United States)

    Online-Offline, 1999

    1999-01-01

    This theme issue on anomalies includes Web sites, CD-ROMs and software, videos, books, and additional resources for elementary and junior high school students. Pertinent activities are suggested, and sidebars discuss UFOs, animal anomalies, and anomalies from nature; and resources covering unexplained phenonmenas like crop circles, Easter Island,…

  20. A spectrum of bronchopulmonary anomalies associated with tracheoesophageal malformations

    International Nuclear Information System (INIS)

    The combination of tracheoesophageal and pulmonary malformations is unusual and reportedly carries a high mortality. We have observed six patients with esophageal atresia and tracheoesophageal fistula and one with a bronchoesophageal fistula who had associated bronchopulmonary anomalies ranging from lobar hypoplasia and agenesis to unilateral pulmonary hypoplasia or agenesis. All of the pulmonary malformations were right-sided. Vertebral or rib anomalies were present in five patients, congenital heart disease in two, imperforate anus in one and one patient had radial aplasia and Pierre Robin syndrome. The bronchopulmonary anomalies complicated the surgical care of tracheoesophageal malformations and required radiologic differentiation from aspiration pneumonia and atelectasis. Six of the seven patients survived. Mortality and morbidity were related to complications and associated cardiac anomalies as well as severity of the lung anomaly. (orig.)

  1. An application of x-ray computed tomography for complex cardiac anomalies

    International Nuclear Information System (INIS)

    X-ray computed tomography (CT) was performed in two patients with complex congenital heart disease in order to assess the clinical utility in the systemic morphological diagnosis. A Somotom 2 whole body CT scanner (Siemens Co) was used, and contrast enhanced CT scannings and a dynamic CT scanning were performed in one case (Case 2).; Case 1: A 20-year-old female with double outlet right ventricle (S, D, L), pulmonary stenosis and aortic insufficiency. The CT revealed a visceroatrial situs, ventriculoarterial relation, spatial interrelationship between the great arteries and a run of the stenotic pulmonary artery. The CT clarified spatial relationship among four cardiac chambers, ventricular septal defect and great arteries, contributing to the understanding of the complex cardiac structure. Case 2: A 26-year-old female with single ventricle (III-C solitus), pulmonary stenosis, dextroversion, left superior vena cava and WPW syndrome. The CT documented precisely a visceroatrial situs, dextroversion, ventriculoarterial relation, spatial interrelationship between the great arteries, stenotic main and left pulmonary arteries and a dilated right pulmonary artery due to the right Blalock-Taussig operation performed 15 years before. A diagnosis of left superior vena cava could be made by CT, and its flow into coronary sinus was visualized by dynamic CT. The dynamic CT also clarified a mixing of venous and arterial blood in the common ventricle, and revealed a rudimentary ventricular septum. Thus, the CT serves useful purposes especially as examination of visceroatrial situs, ventriculoarterial relation and spatial interrelationship between great arteries, and anomalies of the mediastinal vessels. Furthermore the relationship among four cardiac chambers, ventricular septal defect, and the pattern of blood flow were also clarified. (J.P.N.)

  2. Fluorescence in situ hybridization (FISH screening for the 22q11.2 deletion in patients with clinical features of velocardiofacial syndrome but without cardiac anomalies

    Directory of Open Access Journals (Sweden)

    Paula Sandrin-Garcia

    2007-01-01

    Full Text Available The velocardiofacial syndrome (VCFS, a condition associated with 22q11.2 deletions, is characterized by a typical facies, palatal anomalies, learning disabilities, behavioral disturbances and cardiac defects. We investigated the frequency of these chromosomal deletions in 16 individuals with VCFS features who presented no cardiac anomalies, one of the main characteristics of VCFS. Fluorescent in situ hybridization (FISH with the N25 (D22S75; 22q11.2 probe revealed deletions in ten individuals (62%. Therefore, even in the absence of cardiac anomalies testing for the 22q11.2 microdeletions in individuals showing other clinical features of this syndrome is recommended.

  3. Congenital keratoglobus with multiple cardiac anomalies: a case presentation and literature review.

    Science.gov (United States)

    Ozer, Pinar A; Yalniz-Akkaya, Zuleyha

    2015-07-01

    Keratoglobus is a rare condition of bilateral corneal ectasia, which results in high myopia, irregular astigmatism, scarring, and rarely spontaneous globe rupture. Globoid protrusion of a clear, diffusely thin cornea is the pathology. The congenital form has been associated with blue sclera in which there is a systemic connective tissue disorder with abnormal collagen synthesis like Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta. Some concomitant abnormalities reported with kertoglobus include joint hypermobility, dental and skeletal abnormalities, osteal fragility, and deafness. Acquired forms have been reported to be associated with vernal keratoconjunctivitis and thyroid ophthalmopathy. We report the case of a 16-year-old boy with keratoglobus who presented with a history of photophobia and a low vision in both eyes since birth. He has been followed up by our pediatric cardiology department due to multiple cardiac anomalies. He had hypermobility of large joints, easy bruising, thin and hyperextensible skin with visible veins, which were also described in his elder brother. We aimed to discuss the etiology and the association of keratoglobus with some systemic abnormalities caused by collogen tissue disturbance, and make a brief review about the recent literature concerning the management of keratoglobus patients. PMID:24409942

  4. 64. The prevalence of coronary artery anomalies in Qassim province detected by cardiac computed tomography angiography

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    O. smettei

    2016-07-01

    Full Text Available Coronary artery anomalies (CAAs affect about 1% of the general population based on invasive coronary angiography (ICA data, computed tomography angiography (CTA enables better visualization of the origin, course, relation to the adjacent structures, and termination of CAAs compared to ICA. The aim of our work is to estimate the frequency of CAAs in Qassim province among patients underwent cardiac CTA at PSCCQ. Retrospective analysis of the CTA data of 2235 patients between 2009 and 2015. The prevalence of CAAs in our study was 1.029%. Among the 2235 patients, 241 (10.78% had CAAs or coronary variants, 198 (8.85% had myocardial bridging, 34 (1.52% had a variable location of the Coronary Ostia, Twenty two (0.98% had a separate origin of left anterior descending (LAD and left circumflex coronary (LCX arteries, ten (0.447% had a separate origin of the RCA and the Conus artery. Seventeen (0.76% had an anomalous origin of the coronaries. Six (0.268% had a coronary artery fistula, which is connected mainly to the right heart chambers, one of these fistulas was complicated by acute myocardial infarction. The incidence of CAAs in our patient population was similar to the former studies, CTA is an excellent tool for diagnosis and guiding the management of the CAAs.

  5. Cardiac Magnetic Resonance Imaging Findings in a Patient with Ebstein’s Anomaly and Left Ventricular Dysfunction

    OpenAIRE

    Nasim Naderi; Ahmad Amin; Hamidreza Pouraliakbar

    2013-01-01

    Ebstein anomaly is characterized by apical displacement of the septal and posterior tricuspid valve leaflets, leading to atrialization of the right ventricle and could be diagnosed in a routine transthoracic echocardiography exam. We reported a young man with right sided heart failure symptoms who was found to have biventricular failure with suspected apical displacement of septal leaflet of tricuspid valve. For better evaluation, cardiac magnetic resonance imaging (CMR) was performed and nic...

  6. Interventional treatment of common congenital heart diseases: the common view of Chinese medical experts. Part Five-transcatheter intervention for the treatment of compound congenital cardiac anomalies

    International Nuclear Information System (INIS)

    Compound congenital cardiac anomalies refer to two or more congenital cardiovascular defects coexisting in the same patient. Transcatheter intervention for compound congenital cardiac anomalies has got satisfactory results in recent years. However, the percutaneous closure procedure used for compound congenital cardiac defects does not mean the simple addition of single interventional technique. Clinically, it needs more specialist expertise to deal with such complex defects. This chapter will briefly describe the pathophysiology and clinical features of the following compound congenital cardiac anomalies: the ventricular septal defect (VSD) with coexistence of atrial septal defect (ASD), patent ductus arteriosus (PDA) or pulmonary valve stenosis (PS), the ASD coexistence of PDA, PS or mitral stenosis (Lutembacher's syndrome), and coarctation of aorta compound with PDA. The indications and contraindications, the therapeutic principles, the matters needing attention, the postoperative management, the judgment of curative effect, etc. of using transcatheter for the treatment of such compound anomalies will also be discussed. (authors)

  7. Diphallus with Imperforate Anus and Complete Duplication of Recto-Sigmoid Colon and Lower Urinary Tract

    Directory of Open Access Journals (Sweden)

    Shaghayegh Hasas-yeganeh

    2010-06-01

    Full Text Available Background:Diphallus is a rare anomaly and accompanying anomalies vary from bifid scrotum, bladder exstrophy, imperforate anus and colo-rectal anomaly such as duplication, and other associated anomalies. Case Presentation:A 2-day old infant is reported with imperforate anus and complete duplication of recto-sigmoid colon, rectal pouch, doubling of the genitalia with completely formed penis (diphallus, double bladder, urethra and hypospadias. No family history of abnormalities was noted. The patient underwent several operations: laparatory and colostomy at 3rd day of life, and after clinical and paraclinical investigations, cystoplasty, ureteral reimplantation and resection of left phallus were carried out when 4 months old. At the age of 1 year, after colostogram and total colon evaluation, laparatomy, resection of duplicated recto-sigmoid colon, and pull-through was carried out; 3 months later colostomy closure was performed and the patient discharged without complications. Conclusion:The patients with diphallus have to be examined carefully because of the high incidence of other systemic anomalies. Treatment of diphallus usually includes excision of the duplicated penile structure, its urethra, and repair of associated anomalies.

  8. Diphallus with Imperforate Anus and Complete Duplication of Recto-Sigmoid Colon and Lower Urinary Tract

    Directory of Open Access Journals (Sweden)

    Alireza Mirshemirani

    2010-02-01

    Full Text Available Background:Diphallus is a rare anomaly and accompanying anomalies vary from bifid scrotum, bladder exstrophy, imperforate anus and colo-rectal anomaly such as duplication, and other associated anomalies. Case Presentation:A 2-day old infant is reported with imperforate anus and complete duplication of recto-sigmoid colon, rectal pouch, doubling of the genitalia with completely formed penis (diphallus, double bladder, urethra and hypospadias. No family history of abnormalities was noted. The patient underwent several operations: laparatory and colostomy at 3rd day of life, and after clinical and paraclinical investigations, cystoplasty, ureteral reimplantation and resection of left phallus were carried out when 4 months old. At the age of 1 year, after colostogram and total colon evaluation, laparatomy, resection of duplicated recto-sigmoid colon, and pull-through was carried out; 3 months later colostomy closure was performed and the patient discharged without complications.Conclusion:The patients with diphallus have to be examined carefully because of the high incidence of other systemic anomalies. Treatment of diphallus usually includes excision of the duplicated penile structure, its urethra, and repair of associated anomalies.

  9. Management of Epidermoid Carcinoma of the anus

    International Nuclear Information System (INIS)

    In two unselected, consecutive and population-based patient materials from two regions in Sweden, different treatment modalities in patients with epidermoid carcinoma of the anus have been evaluated. By using a primary radiotherapeutic approach, combined with surgery in patients with large and/or less radiosensitive tumors, considerably more surviving patients can be disease-free in the long term compared with a primarily surgical approach. In addition, several patients will have preserved anal function. Based upon these data together with the experience described in the literature, we conclude that surgery is no longer the primary treatment of choice in patients with anal carcinoma. (authors)

  10. Case Series: Fetal Pulmonary Vein A-Wave Reversal: An Early Marker of Left-Sided Cardiac Anomalies?

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    Aldo L. Schenone

    2015-04-01

    Full Text Available Background - Improvements in congenital heart disease (CHD screening are needed based on the lack of sensitivity of current screening methods and the understanding that the early detection of certain CHDs may improve outcomes. Fetal venous circulation has caught medical attention, and two studies demonstrated that it is feasible to register pulmonary vein flow velocity waveforms (FVWs during early gestation. Meanwhile, the latter study proposed pulmonary vein A-wave reversal as a marker of cardiac anomaly. Methods - We report a series of six consecutive fetuses with confirmed cardiac anomalies that underwent first-trimester screening, including pulmonary vein FVWs, at our center during 2013. CHD was confirmed by late pregnancy echocardiography, and in three cases fetal autopsies were performed. Result/Discussion - The ductus venosus (DV and nuchal translucency (NT predicted 50% of CHD cases, whereas the combination of markers identified 66.6% of CHD cases. When adding pulmonary vein assessment, the rate of detection rose to 83.3%. Total five of six cases of CHD had reversal of pulmonary vein A-wave during early pregnancy. The sixth case with CHD and nonreversal of A-wave was described as right ventricle hypoplasia with type 1 tricuspid atresia and persistent ductus arteriosus. Conclusion This is the first series reporting pulmonary vein end-diastolic reversal as a CHD screening add-on during early pregnancy. The addition of pulmonary vein FVW assessment to the current CHD screening bundle could increase the rate detection of cardiac anomalies. This pilot study suggests that pulmonary vein end-diastolic flow reversal favors detection of left-sided CHD over the right-sided ones.

  11. Multidetector CT and MRI of ostial atresia of the coronary sinus, associated collateral venous pathways and cardiac anomalies

    International Nuclear Information System (INIS)

    Aim: To analyse the multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI) findings in patients with atresia of the coronary sinus orifice (CSA). Materials and methods: MDCT findings of 15 consecutive adult patients with CSAs were retrospectively analysed. The patients underwent contrast-enhanced electrocardiography-gated MDCT (n = 13) or both CT and MRI (n = 2). Results: The mean size of the coronary sinus (CS) was 14.2 mm (range 5.5–24 mm) and 11 patients (73.3%) showed CS dilatation (diameter ≥12 mm). The mean length of the atretic CS segment was 2.9 mm (range 0–8 mm). Different forms of venous collateral pathways were observed in the CSA patients. Nine (60%) of the 15 CSA patients had communication between the right atrium (RA; n = 6) or LA (n = 5) and CS via intraseptal veins; six patients (40%) had persistent left superior caval veins; communications were also observed between the CS and RA (n = 4) or LA (n = 4); two patients had collateral venous pathways between dilated cardiac veins with RA; two patients had unroofing of the CS as outlet channels. Nine patients (60%) had cardiac anomalies: coronary artery fistula to the pulmonary artery (n = 6) or left ventricular base and CS (n = 1), atrial septal defects (n = 2), and a ventricular septal defect (n = 1). Conclusion: CSA patients have venous collateral pathways and a high incidence of associated cardiovascular anomalies such as coronary artery fistulae and atrial septal defects.

  12. Rare association in a female DSD case of phallus, accessory phallic urethra, perineal lipoma and anterior ectopic anus.

    Science.gov (United States)

    Mahalik, Santosh Kumar; Mahajan, Jai Kumar; Sodhi, Kushaljit Singh; Garge, Saurabh; Vaiphei, Kim; Rao, Kattragadda L

    2013-02-01

    Disorders of sex differentiation (DSD) are a heterogeneous and broad spectrum group of diseases with a varied appearance. Presence of an accessory phallus with a phallic urethra in association with a normal vagina in a female is an extremely uncommon anomaly. We present a rare case of a genotypically female child with a normal urethra and vagina in association with a phallus, accessory phallic urethra, perineal lipoma and anterior ectopic anus. PMID:22836203

  13. Anesthetic dilemma in planning bilateral cataract surgery for an infant associated with congenital cardiac anomaly

    Directory of Open Access Journals (Sweden)

    Devalina Goswami

    2015-01-01

    Full Text Available In a patient with tetralogy of Fallot (TOF and pulmonary atresia, treating the cardiac problem or the associated congenital illness is always a challenge. We describe the challenges and successful initial management of bilateral cataract to prevent visual loss in an infant with TOF with pulmonary atresia.

  14. Total Cavopulmonary Connection for Complex Cardiac Anomalies with the Functional Single Ventricle

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    From Aug. 1999 to Feb. 2001, 8 patients with complex congenital heart diseases, including 5 cases accompanied by hypoplastic left ventricle and 3 by hypoplastic right ventricle, were subjected to total cavopulmonary connection (TCPC). Eight cases underwent the operation under cardiopulmonary bypass and 7 of whom under no cardiac clamp. Seven cases received cavopulmoanry anastomosis by flaring method and one case by end-side anastomosis. All the patients underwent the intracardiac tunnels to drain inferior vena cava and plus 4 mm fenestration except one. The results showed that 6 patients had postoperative oxygen saturation more than 90 %, sinus rhythm, no anastomostic stoma obstruction, no flow reguigitation and CVP<16 cmH2O. Two (25 %) patients died postoperatively from high venous pressure of 18—20 cmH2O, finally from cardiac failure and anoxima. It was concluded that TCPC was an effective treatment for complex congenital cardiac diseases, especially with ventricular maldevelopment. Intracardiac tunnel plus 4 mm fenestration and flaring cavopulmonary anastomosis could prevent the postoperative complications. Larger anastomotic stoma, venous pressure less than 16 cmH2O and artery saturation more than 90 % might indicate excellent TCPC procedures in our experience.

  15. Chemoradiation for adenocarcinoma of the anus

    International Nuclear Information System (INIS)

    actuarial rate 66%) than in patients with epidermoid carcinoma (5-year actuarial rate 10%, p<0.001). The 5-year actuarial disease-free survival and overall survival rate for adenocarcinoma patients was 19% and 64%, respectively, compared with 77% (p<0.0001) and 85% (p=0.017) for those with epidermoid carcinoma. Conclusion: Patients with localized adenocarcinoma of the anus treated with definitive chemoradiation had high rates of pelvic failure and distant metastasis compared with comparably staged patients with epidermoid histologic features treated similarly. On the basis of these limitations, we recommend preoperative chemoradiation followed by abdominoperineal resection to maximize pelvic disease control and consideration of adjuvant chemotherapy to address the problem of micrometastatic disease

  16. Fourier analysis of multi-gated cardiac blood-pool data in patients with congenital heart diseases, (2). Assessment of diseases with complex cardiac anomalies, especially tetralogy of Fallot

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, Kan; Maeda, Hisato; Yamaguchi, Nobuo; Nakamura, Kazuyoshi; Matsumura, Kaname; Nakagawa, Tsuyoshi; Sakurai, Minoru; Aoki, Kenzo

    1985-04-01

    The clinical usefulness of Fourier analysis of multi-gated cardiac blood-pool data was evaluated in 18 subjects with normal cardiac functions and 14 patients with complex cardiac anomalies (ten with tetralogy of Fallot, two with tricuspid atresia (TA), one with double-outlet right ventricle (DORV), and one with Ebstein's anomaly (EA)). Using global ventricular time-activity curves, the phase and amplitude at fundamental frequency were calculated, and emptying patterns of the left and right ventricles (LV, RV) were evaluated by phase difference (D(phase)=RV phase minus LV phase) and amplitude ratio of RV to LV (R(amp)). In patients with TOF, mean values of D (phase) and R(amp) were 25.3 +- 10.5 degrees and 13.5 +- 0.49 respectively and significantly larger than those of normal subjects. D (phase) became larger in inverse proportion to the ratio of pulmonary-to-systemic blood flow and there was an inverse linear correlation between these two variables. On visual interpretation of functional images, the dynamic property of hypoplastic ventricles could be easily estimated in patients with TA or DORV. In a case with EA, the atrialized RV was shown clearly as a hypokinetic, atrial phase area. This method is valuable for pathophysiologic investigation of diseases with complex cardiac anomalies. (author).

  17. Assessment of the intrapulmonary ventilation-perfusion distribution after the Fontan procedure for complex cardiac anomalies: Relation to pulmonary hemodynamics

    International Nuclear Information System (INIS)

    In 12 patients who underwent the Fontan procedure for complex cardiac anomalies, lung scanning with xenon-133 was performed to assess the intrapulmonary ventilation-perfusion distribution, and comparison was made with a control group. All data were then analyzed in relation to either pre- or postoperative pulmonary hemodynamic data. In ventilation scans, the intrapulmonary distribution in the right lung was almost normal. In perfusion scans, an abnormal increased upper to lower lobe perfusion ratio greater than the normal value found in the control group was noted in seven patients (58.3%). There was a significant correlation (p less than 0.02) between the upper to lower lobe perfusion ratio and postoperative pulmonary vascular resistance. Furthermore, this perfusion ratio correlated inversely with the preoperative (p less than 0.005) and postoperative (p less than 0.02) right pulmonary artery area index, defined as the ratio of cross-sectional area to the normal value. Of five patients with less than 90% arterial oxygen saturation, four showed an abnormal distribution of pulmonary blood flow greater than the normal perfusion ratio. No patient had evidence of a pulmonary arteriovenous fistula by the echocardiographic contrast study. These results suggest that abnormal distribution of pulmonary blood flow to the upper lung segment may develop in patients after the Fontan procedure, and that insufficient size of the pulmonary artery before operation and the consequent postoperative elevation of pulmonary vascular resistance may be responsible for this perfusion abnormality

  18. The Imperforate Anus Psychosocial Questionnaire (IAPSQ: Its construction and psychometric properties

    Directory of Open Access Journals (Sweden)

    Christensson Kyllike

    2009-05-01

    Full Text Available Abstract The origin of the present study was to develop the liaison work between the disciplines of child and adolescent psychiatry and paediatric surgery and nursing, so as to improve the quality of treatment and care of a group of children with imperforate anus (IA and their families. Imperforate anus is a congenital disease involving a deformity of the anorectum. The early surgery and invasive follow-up treatment associated with IA may affect the child psychosocially, including the child-parent relationship. By developing and testing a questionnaire for children born with anorectal anomalies, a tool for measuring psychosocial functioning can be realized. Methods First, a literature review on "Imperforate Anus" was performed. Second, an exploratory interview study was conducted with patients/adolescents with IA and their parents. The findings from these interviews were the foundation for construction of the questionnaire. The Imperforate Anus Psychosocial Questionnaire (IAPSQ was tested and revised three times before its completion. It contains 45 items on Likert scales. A total of 87 children completed the IAPSQ: 25 children with IA and two comparison groups. Face and content validity were considered. The Rasch approach, an item response theory model, was used to evaluate the psychometric properties of the IAPSQ, where item difficulty and person ability are concurrently approximated. Results The findings of the Rasch analysis revealed that the psychological dimension was reasonable, and that person reliability (0.83 was moderate and item reliability (0.95 was sufficient. The social dimension showed satisfactory item reliability (0.87. The person reliability (0.52 of the social dimension was weak. Content validity seemed to be established and construct validity was recognized on the psychological dimension. Conclusion The IAPSQ provides a reasonably valid and reliable measure of psychosocial functioning for clinical use among children with IA

  19. Delayed diagnosis of imperforate anus: an unacceptable morbidity.

    LENUS (Irish Health Repository)

    Turowski, Carmen

    2010-11-01

    Diagnosis of imperforate anus is usually made shortly after birth with physical examination. Nonetheless, a significant number of patients have presented beyond the neonatal period without recognition of anorectal malformation. We reviewed our experience of anorectal malformations, with particular emphasis on the timing of diagnosis.

  20. Iron deposition following chronic myocardial infarction as a substrate for cardiac electrical anomalies: initial findings in a canine model.

    Directory of Open Access Journals (Sweden)

    Ivan Cokic

    Full Text Available PURPOSE: Iron deposition has been shown to occur following myocardial infarction (MI. We investigated whether such focal iron deposition within chronic MI lead to electrical anomalies. METHODS: Two groups of dogs (ex-vivo (n = 12 and in-vivo (n = 10 were studied at 16 weeks post MI. Hearts of animals from ex-vivo group were explanted and sectioned into infarcted and non-infarcted segments. Impedance spectroscopy was used to derive electrical permittivity ([Formula: see text] and conductivity ([Formula: see text]. Mass spectrometry was used to classify and characterize tissue sections with (IRON+ and without (IRON- iron. Animals from in-vivo group underwent cardiac magnetic resonance imaging (CMR for estimation of scar volume (late-gadolinium enhancement, LGE and iron deposition (T2* relative to left-ventricular volume. 24-hour electrocardiogram recordings were obtained and used to examine Heart Rate (HR, QT interval (QT, QT corrected for HR (QTc and QTc dispersion (QTcd. In a fraction of these animals (n = 5, ultra-high resolution electroanatomical mapping (EAM was performed, co-registered with LGE and T2* CMR and were used to characterize the spatial locations of isolated late potentials (ILPs. RESULTS: Compared to IRON- sections, IRON+ sections had higher[Formula: see text], but no difference in[Formula: see text]. A linear relationship was found between iron content and [Formula: see text] (p1.5% with similar scar volumes (7.28% ± 1.02% (Iron (1.5%, p = 0.51 but markedly different iron volumes (1.12% ± 0.64% (Iron (1.5%, p = 0.02, QT and QTc were elevated and QTcd was decreased in the group with the higher iron volume during the day, night and 24-hour period (p<0.05. EAMs co-registered with CMR images showed a greater tendency for ILPs to emerge from scar regions with iron versus without iron. CONCLUSION: The electrical behavior of infarcted hearts with iron appears to be different from those without iron. Iron within infarcted zones may

  1. Tracheobronchial Branching Anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Min Ji; Kim, Young Tong; Jou, Sung Shick [Soonchunhyang University, Cheonan Hospital, Cheonan (Korea, Republic of); Park, A Young [Soonchunhyang University College of Medicine, Asan (Korea, Republic of)

    2010-04-15

    There are various congenital anomalies with respect to the number, length, diameter, and location of tracheobronchial branching patterns. The tracheobronchial anomalies are classified into two groups. The first one, anomalies of division, includes tracheal bronchus, cardiac bronchus, tracheal diverticulum, pulmonary isomerism, and minor variations. The second one, dysmorphic lung, includes lung agenesis-hypoplasia complex and lobar agenesis-aplasia complex

  2. A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation

    Science.gov (United States)

    Chang, Eileen I.; Terada, Ryota; Ryan, Nicole J.; Briggs, Laura E.; Chowdhury, Rajib; Zárate, Miguel A.; Sugi, Yukiko; Nam, Hyun-Joo; Benson, D. Woodrow; Anderson, Robert H.; Kasahara, Hideko

    2014-01-01

    Background Heterozygous human mutations of NKX2-5 are highly penetrant and associated with varied congenital heart defects. The heterozygous knockout of murine Nkx2-5, in contrast, manifests less profound cardiac malformations, with low disease penetrance. We sought to study this apparent discrepancy between human and mouse genetics. Since missense mutations in the NKX2-5 homeodomain (DNA binding domain) are the most frequently reported type of human mutation, we replicated this genetic defect in a murine knock-in model. Methods and Results We generated a murine model in a 129/Sv genetic background by knocking-in an Nkx2-5 homeodomain missense mutation previously identified in humans. The mutation was located at homeodomain position 52Arg→Gly (R52G). All the heterozygous neonatal Nkx2-5+/R52G mice demonstrated a prominent trabecular layer in the ventricular wall, so called noncompaction, along with diverse cardiac anomalies, including atrioventricular septal defects, Ebstein’s malformation of the tricuspid valve, and perimembranous and/or muscular ventricular septal defects. In addition, P10 Nkx2-5+/R52G mice demonstrated atrial septal anomalies, with significant increase in the size of the inter-atrial communication and fossa ovalis, and decrease in the length of the flap valve compared to control Nkx2-5+/+ or Nkx2-5+/− mice. Conclusion The results of our study demonstrate that heterozygous missense mutation in the murine Nkx2-5 homeodomain (R52G) are highly penetrant, and result in pleiotropic cardiac effects. Thus, in contrast to heterozygous Nkx2-5 knockout mice, the effects of the heterozygous knock-in mimic findings in humans with heterozygous missense mutation in NKX2-5 homeodomain. PMID:25028484

  3. De novo 14q24.2q24.3 microdeletion including IFT43 is associated with intellectual disability, skeletal anomalies, cardiac anomalies, and myopia.

    Science.gov (United States)

    Stokman, Marijn F; Oud, Machteld M; van Binsbergen, Ellen; Slaats, Gisela G; Nicolaou, Nayia; Renkema, Kirsten Y; Nijman, Isaac J; Roepman, Ronald; Giles, Rachel H; Arts, Heleen H; Knoers, Nine V A M; van Haelst, Mieke M

    2016-06-01

    We report an 11-year-old girl with mild intellectual disability, skeletal anomalies, congenital heart defect, myopia, and facial dysmorphisms including an extra incisor, cup-shaped ears, and a preauricular skin tag. Array comparative genomic hybridization analysis identified a de novo 4.5-Mb microdeletion on chromosome 14q24.2q24.3. The deleted region and phenotype partially overlap with previously reported patients. Here, we provide an overview of the literature on 14q24 microdeletions and further delineate the associated phenotype. We performed exome sequencing to examine other causes for the phenotype and queried genes present in the 14q24.2q24.3 microdeletion that are associated with recessive disease for variants in the non-deleted allele. The deleted region contains 65 protein-coding genes, including the ciliary gene IFT43. Although Sanger and exome sequencing did not identify variants in the second IFT43 allele or in other IFT complex A-protein-encoding genes, immunocytochemistry showed increased accumulation of IFT-B proteins at the ciliary tip in patient-derived fibroblasts compared to control cells, demonstrating defective retrograde ciliary transport. This could suggest a ciliary defect in the pathogenesis of this disorder. © 2016 Wiley Periodicals, Inc. PMID:26892345

  4. Early Developmental Assessment of Children with Major Non-Cardiac Congenital Anomalies Predicts Development at the Age of 5 Years

    Science.gov (United States)

    Mazer, Petra; Gischler, Saskia J.; van der Cammen-van Zijp, Monique H. M.; Tibboel, Dick; Bax, Nicolaas M. A.; Ijsselstijn, Hanneke; van Dijk, Monique; Duivenvoorden, Hugo J.

    2010-01-01

    Aim: The aim of this study was to evaluate cognitive and motor development in children with major congenital anomalies and the predictability of development at age 5 years. Method: A prospective, longitudinal follow-up study was undertaken. The Dutch version of the Bayley Scales of Infant Development--Mental Developmental Index (MDI) and…

  5. 先天性无肛与腰骶椎异常%Congenital Imperforate Anus and Abnormality of Lumbosacral Vertabae

    Institute of Scientific and Technical Information of China (English)

    李正; 王练英

    1990-01-01

    The anterior-posterior and lateral roentgenogram of the lumbar and sacral vertebrae of 113 cases(males 59,females 54)with imperforate anus that underwent operations over 5 years ago,were studied.Of them,32 cases had high lesions of anorectal anomalies.40 had intermediate lesions and 41 had low lesions.Twenty-one newborns were selected as a control.The X-ray findings showed that the lumbar anomalies were found in 11 cases (11.3%)of imperforate anus group,and only two in the control.The sac-al malforma:ions in high lesions and low lesions were 62.5% and 36.6% respectively and the intermediate were between the two.Most of the high lesions associated with multiple sacral defects.The sacral vertebral defects consisted of absence of vertebrae and agenesia(41).flat sacrum(30),spina bifida oceulta(28)and sacro-lumbarization(9).%本文报道113例无肛患儿伴腰骶椎异常的情况,97例腰骶椎完整的X线片上,有异常者52例(53.6%),对照组仅2例(9.5%).在113例骶椎X线片上,57例(50.4%)有各种异常共94例次,其中23例有2个以上异常.无肛畸形位置越高,骶骨异常,特别是多发性异常越多.

  6. Characterization of a complex rearrangement involving duplication and deletion of 9p in an infant with craniofacial dysmorphism and cardiac anomalies

    Directory of Open Access Journals (Sweden)

    Di Bartolo Daniel L

    2012-07-01

    Full Text Available Abstract Partial duplication and partial deletion of the short arm of chromosome 9 have each been reported in the literature as clinically recognizable syndromes. We present clinical, cytogenetic, and molecular findings on a five-week-old female infant with concomitant duplication and terminal deletion of the short arm of chromosome 9. To our knowledge ten such cases have previously been reported. Conventional cytogenetic analysis identified additional material on chromosome 9 at band p23. FISH analysis aided in determining the additional material consisted of an inverted duplication with a terminal deletion of the short arm. Microarray analysis confirmed this interpretation and further characterized the abnormality as a duplication of about 32.7 Mb, from 9p23 to 9p11.2, and a terminal deletion of about 11.5 Mb, from 9p24.3 to 9p23. The infant displayed characteristic features of Duplication 9p Syndrome (hypotonia, bulbous nose, single transverse palmar crease, cranial anomalies, as well as features associated with Deletion 9p Syndrome (flat nasal bridge, long philtrum, cardiac anomalies despite the deletion being distal to the reported critical region for this syndrome. This case suggests that there are genes or regulatory elements that lie outside of the reported critical region responsible for certain phenotypic features associated with Deletion 9p Syndrome. It also underscores the importance of utilizing array technology to precisely define abnormalities involving the short arm of 9p in order to further refine genotype/phenotype associations and to identify additional cases of duplication/deletion.

  7. Three-dimensional images facilitate to understand anorectal pull-through route for patients with imperforate anus

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Shigeru; Yokoyama, Seishichi; Soeda, Jinichi [Tokai Univ., Isehara, Kanagawa (Japan). School of Medicine] [and others

    1996-12-01

    On reconstructing infrapelvic structure in patients with imperforate anus, it is essential to pull the anorectum through correctly. To apprehend the ideal pull-through route stereoscopically, three-dimensional images of the pelvic structure were obtained after processing MR images from 10 patients with the anomaly and 7 controls. In controls, the infrapelvic muscle structure, which is composed of bilateral superficial perineal muscles, levator muscle complex and sphincter muscle complex, was demonstrated to converge at the center. The rectum was shown stereoscopically to descend through this central portion of the muscle, making an anorectal angle to reach the anal orifice. In those with a low-type anomaly, the rectum was shown to descend in front of the levator muscle complex and the fistula ran through the anterior portion of the sphincter complex without making an anorectal angle. The purpose of the anoplasty for those patients was considered to make a correct anorectal angle. In those with a high-type anomaly, three-dimensional position of the rectal pouch was visualized within the normally-positioned muscle complex but the sphincter muscle was thinner than control patients. For the ideal anoplasty in those patients, the rectum should be conducted into the center of the muscle complex and pulled through in the midst of the thin sphincter mass after making an anorectal angle. Anoplasty procedures should be reevaluated whether they are good for making an ideal pull-through route by three-dimensional images of the infrapelvic organs. (author)

  8. Imperforate Anus: Determination of Type Using Transperineal Ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Young Hun; Kim, In One; Cheon, Jung Eun; Kim, Woo Sun; Yeon, Kyung Mo [Seoul National University Children' s Hospital, Seoul (Korea, Republic of)

    2009-08-15

    This study was designed to assess the usefulness of transperineal ultrasonography (US) for the determination of imperforate anus (IA) type. From January 2000 to December 2004, 46 of 193 patients with an IA underwent transperineal US prior to corrective surgery. Sonographic findings were reviewed to identify the presence of internal fistulas and to determine 'distal rectal pouch to perineum (P-P)' distances. IA types were determined based on the sonographic findings, and the diagnostic accuracy of transperineal US was evaluated based on surgical findings. Of the 46 patients, 17 patients were surgically confirmed as having a high-type IA, three patients were confirmed as having an intermediate-type IA and 26 patients were confirmed as having a low-type IA. The IA type was correctly diagnosed by the use of transperineal US in 39 of the 46 patients (85%). In 14 of the 17 patients with a high-type IA, internal fistulas were correctly identified. All cases with a P-P distance > 16 mm were high-type IAs and all cases with a P-P distance < 5 mm were low-type IAs. Transperineal US is a good diagnostic modality for the identification of internal fistulas in cases of high-type IA and for defining the IA level.

  9. Imperforate Anus: Determination of Type Using Transperineal Ultrasonography

    International Nuclear Information System (INIS)

    This study was designed to assess the usefulness of transperineal ultrasonography (US) for the determination of imperforate anus (IA) type. From January 2000 to December 2004, 46 of 193 patients with an IA underwent transperineal US prior to corrective surgery. Sonographic findings were reviewed to identify the presence of internal fistulas and to determine 'distal rectal pouch to perineum (P-P)' distances. IA types were determined based on the sonographic findings, and the diagnostic accuracy of transperineal US was evaluated based on surgical findings. Of the 46 patients, 17 patients were surgically confirmed as having a high-type IA, three patients were confirmed as having an intermediate-type IA and 26 patients were confirmed as having a low-type IA. The IA type was correctly diagnosed by the use of transperineal US in 39 of the 46 patients (85%). In 14 of the 17 patients with a high-type IA, internal fistulas were correctly identified. All cases with a P-P distance > 16 mm were high-type IAs and all cases with a P-P distance < 5 mm were low-type IAs. Transperineal US is a good diagnostic modality for the identification of internal fistulas in cases of high-type IA and for defining the IA level

  10. Association of congenit anomalia anus rectal with Hirschsprung's disease: a case report

    International Nuclear Information System (INIS)

    The recognition of Hirschsprung's disease is often delayed in children with imperforated anus. Because of this rare association, it is reported one case in which its occurred in conjunction with Down's syndrome. (author)

  11. The Imperforate Anus Psychosocial Questionnaire (IAPSQ): Its construction and psychometric properties

    OpenAIRE

    Christensson Kyllike; Brodin Ulf; Nisell Margret; Rydelius Per-Anders

    2009-01-01

    Abstract The origin of the present study was to develop the liaison work between the disciplines of child and adolescent psychiatry and paediatric surgery and nursing, so as to improve the quality of treatment and care of a group of children with imperforate anus (IA) and their families. Imperforate anus is a congenital disease involving a deformity of the anorectum. The early surgery and invasive follow-up treatment associated with IA may affect the child psychosocially, including the child...

  12. Minimally conjoined omphalopagi: a consistent spectrum of anomalies.

    Science.gov (United States)

    Poenaru, D; Uroz-Tristan, J; Leclerc, S; Murphy, S; St-Vil, D; Youssef, S; Blanchard, H

    1994-09-01

    Omphalapagus twins constitute less than one third of all siamese twins. Most omphalopagi are attached by a skin bridge that often contains hepatic tissue. Only four cases of omphalopagi attached by an intestinal bridge have been reported. The authors present two additional cases of conjoined twins minimally attached by a small bowel and bladder bridge. In both instances, the spectrum of anomalies included a ruptured omphalocele and imperforate anus with cloacal anomalies. The attachment consisted of an open urachal remnant joining the two bladders, and the short small bowel of twin A attached to the terminal ileum of twin B. Separation was uneventful. For one set of twins, the case part of the proximal colon of twin B was used to lengthen the bowel of twin A. Three of the twins survived and underwent additional procedures for repair of the cloacal anomalies. All four previously reported cases of minimally conjoined omphalopagi presented with a remarkably similar spectrum of anomalies. All had ruptured omphaloceles, imperforate anus with cloacal anomalies, and urachal anomalies. Intestinal connection was consistently at a point corresponding to the Meckel diverticulum site of twin B, with blood supply to the small bowel of twin A, probably via the vitelline artery. The consistent spectrum of anomalies encountered with minimally conjoined omphalopagi allows planning of separation. Caution is required to avoid overlooking the patent urachus, and intestinal lengthening procedures based on the vitelline artery become an important consideration. PMID:7807355

  13. Association of Hirschsprung's disease and imperforate anus in a patient with (Cat-eye) syndrome

    International Nuclear Information System (INIS)

    Association of imperforate anus and Hirschsprung's disease is rare, the incidence of both events occurring together would be one child out of every 25 million live births. A case of (cat-eye) syndrome with association of high imperforate and long segment Hirschsprung's disease is presented. (orig.)

  14. Cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Dewey, Marc [Charite - Universitaetsmedizin Berlin (Germany). Inst. fuer Radiologie

    2011-07-01

    Computed tomography of the heart has become a highly accurate diagnostic modality that is attracting increasing attention. This extensively illustrated book aims to assist the reader in integrating cardiac CT into daily clinical practice, while also reviewing its current technical status and applications. Clear guidance is provided on the performance and interpretation of imaging using the latest technology, which offers greater coverage, better spatial resolution, and faster imaging. The specific features of scanners from all four main vendors, including those that have only recently become available, are presented. Among the wide range of applications and issues to be discussed are coronary artery bypass grafts, stents, plaques, and anomalies, cardiac valves, congenital and acquired heart disease, and radiation exposure. Upcoming clinical uses of cardiac CT, such as plaque imaging and functional assessment, are also explored. (orig.)

  15. The long-term management and outcomes of cloacal anomalies.

    OpenAIRE

    Fernando, M. A.; Creighton, S. M.; Wood, D.

    2015-01-01

    Cloacal anomalies occur when failure of the urogenital septum to separate the cloacal membrane results in the urethra, vagina, rectum and anus opening into a single common channel. The reported incidence is 1:50,000 live births. Short-term paediatric outcomes of surgery are well reported and survival into adulthood is now usual, but long-term outcome data are less comprehensive. Chronic renal failure is reported to occur in 50 % of patients with cloacal anomalies, and 26-72 % (dependant on th...

  16. The long-term management and outcomes of cloacal anomalies

    OpenAIRE

    Fernando, M. Ashani; Creighton, Sarah M.; Wood, Dan

    2014-01-01

    Cloacal anomalies occur when failure of the urogenital septum to separate the cloacal membrane results in the urethra, vagina, rectum and anus opening into a single common channel. The reported incidence is 1:50,000 live births. Short-term paediatric outcomes of surgery are well reported and survival into adulthood is now usual, but long-term outcome data are less comprehensive. Chronic renal failure is reported to occur in 50 % of patients with cloacal anomalies, and 26–72 % (dependant on th...

  17. Neonatal Sweet’s Syndrome Associated with Rectovestibular Fistula with Normal Anus

    OpenAIRE

    Jun Shinozuka; Hideki Tomiyama; Shin-ichiro Tanak; Junko Tahara; Hitoshi Awaguni; Shigeru Makino; Rikken Maruyama; Shinsaku Imashuku

    2015-01-01

    Sweet’s syndrome, characterized by fever and a painful erythematous rash with a dermal neutrophilic infiltrate, develops primarily due to paraneoplastic phenomena in adults. Sweet’s syndrome is very rare in neonates. We report a Japanese female neonate (age <2 months), who developed Sweet’s syndrome with episodes of perineal infection in association with congenital rectovestibular fistula with normal anus. Sweet’s syndrome was diagnosed basing on clinical features and histopathology of bio...

  18. Tailgut Cyst in an Infant with Imperforate Anus: a Case Report

    OpenAIRE

    Seyed-Mohammad-Ali Raisolsadat; Nona Zabolinejad; Fariba Tabrizian Namini; Parisa Faraji

    2013-01-01

    Background: Tailgut cyst(TGC) is a rare congenital lesion that originates from remnants of the embryonic post-anal gut.It presents as a multilocular presacral mass mainly in young women.Microscopically,the cyst lining is composed of different types of epithelium such as stratified squamous,transitional, or glandular.Case Presentation: We present a term female newborn that was referred to our hospital for evaluation and management of imperforate anus. During dissection of the presacral space t...

  19. Internal hemorrhoids - their typical radiological appearance and differential diagnosis to carcinoma of rectum and anus

    International Nuclear Information System (INIS)

    The main indication for colon barium enema examination is occult bleeding or bleeding noticed by the patient himself. The radiologist has to take into account all clinical details that could lead to bleeding and to document them. The most frequent causes of rectal bleeding are hemorrhoids and diverticulosis/itis which in marked cases may have a tumor-like appearence. A good double-contrast examination of the colon must not only exclude tumors, polyps or inflammotary diseases but also demonstrate other causes of bleeding. The presented paper describes typical roentgen signs and gives criteria to differentiate hemorrhoids from deeply situated cancer of the rectum or anus. (orig.)

  20. Internal hemorrhoids - their typical radiological appearance and differential diagnosis to carcinoma of rectum and anus

    Energy Technology Data Exchange (ETDEWEB)

    Fiedler, V.; Koester, R.

    1984-11-01

    The main indication for colon barium enema examination is occult bleeding or bleeding noticed by the patient himself. The radiologist has to take into account all clinical details that could lead to bleeding and to document them. The most frequent causes of rectal bleeding are hemorrhoids and diverticulosis/itis which in marked cases may have a tumor-like appearance. A good double-contrast examination of the colon must not only exclude tumors, polyps or inflammatary diseases but also demonstrate other causes of bleeding. The presented paper describes typical roentgen signs and gives criteria to differentiate hemorrhoids from deeply situated cancer of the rectum or anus.

  1. Cervical intraepithelial neoplasia and squamous cell carcinoma of the anus in sexually active women.

    OpenAIRE

    Dixon, A. R.; Pringle, J. H.; Holmes, J. T.; Watkin, D. F.

    1991-01-01

    Twenty-five patients with squamous cell carcinoma (SCC) of the anus have presented over an 8 year period; 18 were female. Six of 9 patients aged under 50 years were female. Five of these women had been treated for a previous cervical malignancy (2 invasive) and 4 practised anal intercourse; human papillomavirus (HPV) type 16 DNAs were isolated from their arcival anal/cervical paraffin sections. Signals were confined to the nuclei of the invasive anal SCC cells and the transformation zone of t...

  2. Radio frequency "sutureless" fistulotomy- a new way of treating fistula in anus

    Institute of Scientific and Technical Information of China (English)

    Pravin J.Gupta

    2003-01-01

    AIM: To explore the effect of the classical lay open technique or fistulotomy with the radio frequency surgical device in the treatment of fistula in anus.METHODS: In our study, the conventional 'lay open'technique, or 'fistulotomy' was performed by employing the radio frequency surgical device as an alternative to the traditional knife and scissors. In a span of 18 months starting from July 1999 to December 2000, 210 cases with fistula in anus of varied types were operated in our nursing home exclusively applying the radio frequency device.RESULTS: The results of the study were not only encouraging but also were satisfactory. A follow up of the operated patients with radio frequency surgery over a period of 15 months, i.e. from December 2000 to March 2002 was summarized as below: (a) average time taken by the patient to resume routine - 7 days; (b) none of the patient had any interference with the continence; (c) the wounds were found healed within an average time of 47 days; (d) delayed wound healing was noticed only in 7 patients; (e) recurrence/failure rate was reduced to as low as 1.5 percent.CONCLUSION: This technique has been found superior to the conventional fistulotomy in the sense that the time taken for the whole procedure is reduced to almost half, chances of bleeding are reduced to a minimum and the use of suture material is dispensed with. The procedure can safely be called a "Sutureless fistulotomy".

  3. The separation of pygopagus conjoined twins with fused spinal cords and imperforate anus

    Directory of Open Access Journals (Sweden)

    Barrett P. Cromeens

    2016-08-01

    Full Text Available Each set of conjoined twins has specific anatomic features dictating unique challenges to separation. Overcoming these challenges requires creative solutions that necessitate interdisciplinary collaboration. We present a unique case of pygopagus conjoined twins with fused spinal cords, imperforate anus without fistula, and a single anal sphincter complex. Separation included the use of novel applications of 3D printing and neurophysiologic monitoring. The 3D print helped to clarify the complex anatomy and facilitate communication during planning sessions. The neurophysiologic monitoring helped to distinguish a plane of separation for the spinal cords as well as the shared anal sphincter. Implementing these technologies and thus successfully separating these twins safely required a multidisciplinary team that extended beyond clinical specialties.

  4. Pictorial review of coronary anomalies in Tetralogy of Fallot.

    Science.gov (United States)

    Kapur, Sangita; Aeron, Gunjan; Vojta, Christopher N

    2015-01-01

    Tetralogy of Fallot (TOF) classically consists of four characteristic features-right ventricular outflow obstruction, right ventricular hypertrophy, ventricular septal defect and an overriding aorta. In addition there are multiple other associated cardiac anomalies, including coronary artery anomalies. In this review, the role of CT angiography and the spectrum of coronary anomalies will be discussed along with importance of such anomalies in the context of surgery. PMID:26283594

  5. Sirenomelia with associated systemic anomalies: an autopsy pathologic illustration of a series of four cases.

    Science.gov (United States)

    Chikkannaiah, Panduranga; Mahadevan, Anita; Gosavi, Manasi; Kangle, Ranjit; Anuradha; Shankar, S K

    2014-07-01

    Sirenomelia, a developmental defect involving the caudal region of the body, is associated with several internal visceral anomalies. We report a detailed spectrum of anomalies in an autopsy study of four fetuses with sirenomelia (gestational ages - 20, 21, 22.4, and 22.5 weeks). Three of the fetuses had single umbilical artery, with genitourinary and gastrointestinal anomalies. Central nervous system anomalies were evident in two of the fetuses, with alobar holoprosencephaly in one and lumbar meningomyelocele in another. The most common gastrointestinal anomaly was blind ended gut (imperforate anus), while esophageal atresia and omphalocele were noted in one case each. Renal hypoplasia was seen in two fetuses, renal agenesis in one and cystic renal dysplasia was noted in one case. Literature regarding pathogenesis of this condition is briefly discussed. PMID:24656289

  6. Prevalence of Associated Anomalies in Cleft Lip and/or Palate Patients

    Directory of Open Access Journals (Sweden)

    Shahin Abdollahi Fakhim

    2016-03-01

    Full Text Available Introduction: Orofacial clefts are among the most common congenital anomalies. Patients presenting with orofacial clefts often require surgery or other complex procedures. A cleft lip or palate can be a single anomaly or a part of multiple congenital anomalies. The reported prevalence of cleft disease and associated anomalies varies widely across the literature, and is dependent on the diagnostic procedure used. In this study we determined the prevalence of associated anomalies in patients with a cleft lip and/or palate, with a specific focus on cardiac anomalies. Materials and Methods: In this cross-sectional study, 526 patients with a cleft lip and /or palate admitted to the children’s referral hospital between 2006 and 2011 were evaluated. All associated anomalies were detected and recorded. Patient information collected included age, gender, type and side of cleft, craniofacial anomalies and presence of other anomalies, including cardiac anomalies. Data were analyzed using SPSS version 16.   Results: Of the 526 patients enrolled in the study, 58% (305 were male and 42% (221 were female. In total, 75% of patients (396 were aged between 4 and 8 years and 25% (130 were aged less than 4 years. The most common cleft type in our study was bilateral cleft palate. The most commonly associated anomaly among cleft patients, in 12% of cleft patients, was a cardiac anomaly. The most common cardiac anomaly was atrial septal defect (ASD.   Conclusion:  The prevalence of associated anomalies among orofacial cleft patients is high. The most common associated anomaly is cardiac anomaly, with ASD being the most common cardiac anomaly. There are no significant relationships between type of cleft and associated cardiac anomalies.

  7. Congenital anomalies of the coronary sinus: A pictorial essay

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jung Eun; Kwon, Se Hwan; Oh, Joo Hyeong [Dept. of Radiology, College of Medicine, Kyung Hee University, Seoul (Korea, Republic of)

    2013-07-15

    Congenital anomalies involving the coronary sinus (CS) tend to receive relatively little attention because they rarely cause clinical symptoms or disturbances of cardiac function. However, as imaging modalities have been developed over time, the detailed anatomy of the heart, including CS anomalies, can now be evaluated more precisely. The purpose of this pictorial review is to illustrate multi-detector computed tomography findings of various congenital anomalies of the CS. The cardiac venous system and its embryologic development are also described in detail to familiarize radiologists with various congenital anomalies of the CS.

  8. Congenital anomalies of the coronary sinus: A pictorial essay

    International Nuclear Information System (INIS)

    Congenital anomalies involving the coronary sinus (CS) tend to receive relatively little attention because they rarely cause clinical symptoms or disturbances of cardiac function. However, as imaging modalities have been developed over time, the detailed anatomy of the heart, including CS anomalies, can now be evaluated more precisely. The purpose of this pictorial review is to illustrate multi-detector computed tomography findings of various congenital anomalies of the CS. The cardiac venous system and its embryologic development are also described in detail to familiarize radiologists with various congenital anomalies of the CS.

  9. Squamous cell carcinoma of the anus-an opportunistic cancer in HIV-positive male homosexuals

    Institute of Scientific and Technical Information of China (English)

    Pascal Gervaz; Alexandra Calmy; Ymer Durmishi; Abdelkarim S Allal; Philippe Morel

    2011-01-01

    Squamous cell carcinoma of the anus (SCCA) is a common cancer in the human immunodeficiency virus (HIV)- infected population, and its incidence continues to increase in male homosexuals. Combined chemoradiation with mitomycin C and 5-fluorouracil was poorly tolerated by severely immunocompromised patients in the early 1990s. In the era of highly active antiretroviral therapy (HAART), however, recent data indicate that: (1) most HIV patients with anal cancer can tolerate standard chemotherapy regimens; and (2) this approach is associated with survival rates similar to those of HIV-negative patients. However, HIV-positive patients with SCCA are much younger, more likely to develop local tumor recurrence, and ultimately die from anal cancer than immune competent patients. Taken together, these findings suggest that anal cancer is an often fatal neoplasia in middle- aged HIV-positive male homosexuals. In this population, SCCA is an opportunistic disease resulting in patients with suboptimal immune function from persistent papillomaviruses (HPVs). Large-scale cancer-prevention strategies (routine anuscopy and anal papanicolaou testing) should be implemented in this population. In addition, definitive eradication of oncogenic HPVs within the anogenital mucosa of high-risk individuals might require a proactive approach with repeated vaccination.

  10. Sudden cardiac death

    Directory of Open Access Journals (Sweden)

    Aranđelović Aleksandra Č.

    2004-01-01

    Full Text Available Sudden cardiac death in an athlete is rare and tragic event. An athlete's death draws high public attention given that athletes are considered the healthiest category of society. The vast majority of sudden cardiac death in young athletes is due to congenital cardiac malformations such as hypertrophie cardiomyopathy and various coronary artery anomalies. In athletes over age 35, the usual cause of sudden cardiac death is coronary artery disease. With each tragic death of a young athlete, there is a question why this tragedy has not been prevented. The American College of Sports Medicine and the American Heart Association recommend that a pre-participation exam should include a complete cardiovascular history and physical examination.

  11. Cardiac anomalies in Williams-Beuren syndrome.

    OpenAIRE

    Hallidie-Smith, K A; Karas, S

    1988-01-01

    We have described some of the cardiological findings in 66 patients with Williams-Beuren syndrome and analysed the two dimensional cross sectional echocardiograms in 61 of them in comparison with normal controls. Supravalvar aortic narrowing was shown in all patients examined echocardiographically and may be a useful diagnostic sign. We documented a 7.8% incidence of systemic hypertension, a 15% clinical and echocardiographic incidence of mitral valve prolapse, and a 11.6% incidence of bicusp...

  12. The Influence of Multiple Human Papillomavirus Types on the Risk of Genotype-Concordant Incident Infections of the Anus and Cervix: The Hawaii HPV Cohort Study

    OpenAIRE

    Goodman, Marc T.; McDuffie, Katharine; Hernandez, Brenda Y.; Wilkens, Lynne R.; Zhu, Xuemei; Thompson, Pamela J.; Killeen, Jeffrey; Kamemoto, Lori; Shvetsov, Yurii B.

    2011-01-01

    The influence of multiple human papillomavirus (HPV) types on detection of concordant incident HPV infections of the cervix or anus following infection at the other anatomic site was examined in a cohort of 897 women. Multiple HPV infections at the anus were not significantly associated with subsequent acquisition of a concordant cervical infection, whereas prior coinfections in the cervix increased risk of a new cervical HPV infection. Incident anal HPV infections following concordant cervic...

  13. Associated congenital anomalies among cases with Down syndrome.

    Science.gov (United States)

    Stoll, Claude; Dott, Beatrice; Alembik, Yves; Roth, Marie-Paule

    2015-12-01

    Down syndrome (DS) is the most common congenital anomaly widely studied for at least 150 years. However, the type and the frequency of congenital anomalies associated with DS are still controversial. Despite prenatal diagnosis and elective termination of pregnancy for fetal anomalies, in Europe, from 2008 to 2012 the live birth prevalence of DS per 10,000 was 10. 2. The objectives of this study were to examine the major congenital anomalies occurring in infants and fetuses with Down syndrome. The material for this study came from 402,532 consecutive pregnancies of known outcome registered by our registry of congenital anomalies between 1979 and 2008. Four hundred sixty seven (64%) out of the 728 cases with DS registered had at least one major associated congenital anomaly. The most common associated anomalies were cardiac anomalies, 323 cases (44%), followed by digestive system anomalies, 42 cases (6%), musculoskeletal system anomalies, 35 cases (5%), urinary system anomalies, 28 cases (4%), respiratory system anomalies, 13 cases (2%), and other system anomalies, 26 cases (3.6%). Among the cases with DS with congenital heart defects, the most common cardiac anomaly was atrioventricular septal defect (30%) followed by atrial septum defect (25%), ventricular septal defect (22%), patent ductus arteriosus (5%), coarctation of aorta (5%), and tetralogy of Fallot (3%). Among the cases with DS with a digestive system anomaly recorded, duodenal atresia (67%), Hirschsprung disease (14%), and tracheo-esophageal atresia (10%) were the most common. Fourteen (2%) of the cases with DS had an obstructive anomaly of the renal pelvis, including hydronephrosis. The other most common anomalies associated with cases with DS were syndactyly, club foot, polydactyly, limb reduction, cataract, hydrocephaly, cleft palate, hypospadias and diaphragmatic hernia. Many studies to assess the anomalies associated with DS have reported various results. There is no agreement in the literature as to

  14. An overview of cardiac morphogenesis.

    Science.gov (United States)

    Schleich, Jean-Marc; Abdulla, Tariq; Summers, Ron; Houyel, Lucile

    2013-11-01

    Accurate knowledge of normal cardiac development is essential for properly understanding the morphogenesis of congenital cardiac malformations that represent the most common congenital anomaly in newborns. The heart is the first organ to function during embryonic development and is fully formed at 8 weeks of gestation. Recent studies stemming from molecular genetics have allowed specification of the role of cellular precursors in the field of heart development. In this article we review the different steps of heart development, focusing on the processes of alignment and septation. We also show, as often as possible, the links between abnormalities of cardiac development and the main congenital heart defects. The development of animal models has permitted the unraveling of many mechanisms that potentially lead to cardiac malformations. A next step towards a better knowledge of cardiac development could be multiscale cardiac modelling. PMID:24138816

  15. How to manage pelvic and anus complications of ISR surgery following chemoradiotherapy

    International Nuclear Information System (INIS)

    The aim of this study is to examine the oncologic results and adverse events of neoadjuvant CRT (chemoradiotherapy) followed by ISR (intersphincteric resection) operation. Particularly, we focused how to manage specific pelvic and anus complications of ISR operation. From 1997 to 2012, 256 consecutive patients with adenocarcinoma localized at the lower part of the rectum and anal canal were underwent ISR with/without partial ESR. 220 patients (85.9%) were given CRT in two different doses and fractions (short term CRT and long term CRT), depending on clinical TN stage. Cancer related survival and locoregional recurrence rates were calculated using the Kaplan-Meier method. Median follow-up was 91 months. The actuarial 5-year-local-control rate was 95%. Overall survival for 5 years was 85%. Incidence of complications was significantly higher in long term CRT group (37%) than in short term CRT (14%). Radiation related adverse event such as pelvic infection and skin trouble was significantly higher in the long term CRT group. 32 patients developed pelvic abscess. We managed to control pelvic abscess and succeeded to make 25 of 32 patients stoma free, by addition of dilatation or reconstruction of coloanal anastomosis. Rectovaginal fistula (RVF) occurred in 8 (10% of women). Four patients were succeeded to repair RVF by gracilis muscle interposition flaps, and the rest was healed by extension of fecal diversion period. Local control in ISR surgery after CRT was excellent. At the same time, we could maintain stoma free rate 91%, by protecting and coping with pelvic complications related to ISR and CRT. (author)

  16. Major congenital anomalies in babies born with Down syndrome

    DEFF Research Database (Denmark)

    Morris, Joan K; Garne, Ester; Wellesley, Diana;

    2014-01-01

    Previous studies have shown that over 40% of babies with Down syndrome have a major cardiac anomaly and are more likely to have other major congenital anomalies. Since 2000, many countries in Europe have introduced national antenatal screening programs for Down syndrome. This study aimed to deter...

  17. An overview of cardiac morphogenesis.

    OpenAIRE

    Schleich, Jean-Marc; Abdulla, Tariq; Summers, Ron; Houyel, Lucile

    2013-01-01

    International audience Accurate knowledge of normal cardiac development is essential for properly understanding the morphogenesis of congenital cardiac malformations that represent the most common congenital anomaly in newborns. The heart is the first organ to function during embryonic development and is fully formed at 8 weeks of gestation. Recent studies stemming from molecular genetics have allowed specification of the role of cellular precursors in the field of heart development. In th...

  18. Ritmo de alimentação de juvenis de Loricariichthys anus (Siluriformes, Loricariidae da Lagoa dos Quadros, RS, Brasil Feeding activity of juveniles of Loricariichthys anus (Siluriformes, Loricariidae in the Quadros Lake, RS, Brasil

    Directory of Open Access Journals (Sweden)

    Ana Cristina Petry

    2000-11-01

    Full Text Available The rhythm of movements and feeding activity of juveniles of Loricariichthys anus (Valenciennes, 1840 in the Quadros lake, South Brazil, are investigated. Between October 1997 and August 1998, 236 specimens were captured during six bimonthly 24 hour gillnet surveys. Significantly elevated levels of movement and feeding activity during the day are registered. The patterns of movement and feeding activity displayed no significant difference, suggesting that high movement activity levels can be attributed to feeding activity. The mean of the intestinal quotient was 1,89, indicating omnivorous feeding habits.

  19. Congenital Anomalies in Infant with Congenital Hypothyroidism

    Directory of Open Access Journals (Sweden)

    Zahra Razavi

    2012-09-01

    Full Text Available bjective: Congenital hypothyroidism is characterized by inadequate thyroid hormone production in newborn infants. Many infants with CH have co-occurring congenital malformations. This is an investigation on the frequency and types of congenital anomalies in infants with congenital hypothyroidism born from May 2006-2010 in Hamadan, west province of Iran.Methods: The Iranian neonatal screening program for congenital hypothyroidism was initiated in May 2005. This prospective descriptive study was conducted in infants diagnosed with congenital hypothyroidism being followed up in Pediatric Endocrinology Clinicof Besat Hospital, a tertiary care centre in Hamadan. Cases included all infants with congenital hypothyroidism diagnosed through newborn screening program or detected clinically. Anomalies were identified by clinical examination, echocardiography, and X-ray of the hip during the infant’s first year of life.Results: A total of 150 infants with biochemically confirmed primary congenital hypothyroidism (72 females and 78 males were recruited during the period between May 2006-2010. Overall, 30 (20% infants had associated congenital anomalies. The most common type of anomaly was Down syndrome. Seven infants (3.1% had congenital cardiac anomalies such as: ASD (n=3, VSD (n=2, PS (n =1, PDA (n=1. Three children (2.6% had developmental displasia of the hip (n=3.Conclusion: The overall frequency of Down syndrome, cardiac malformation and other birth defect was high in infants with CH. This reinforces the need to examine all infants with congenital hypothyroidism for the presence of associated congenital anomalies.

  20. Associated congenital anomalies: Vestibular fistula, duodenal atresia and obstructive refluxing megaureter

    Directory of Open Access Journals (Sweden)

    Bukarica Svetlana S.

    2004-01-01

    Full Text Available Congenital gastrointestinal anomalies include spectrum of malformations, simple ones as well as complex, which are associated with anomalies of other organs and systems of organs. Most infants (50-60% with imperforate anus also have genitourinary, cardiovascular, gastrointestinal and vertebral anomalies. This case report is of a female newborn with prenatally diagnosed duodenal atresia and right hydronephrosis. Clinical investigation revealed an imperforate anus with vestibular fistula. A plain abdominal x-ray showed a "double-bubble” sign, characteristic for duodenal atresia. Intraluminal membrane was excised and sigmoid colostomy was performed in general anesthesia on the first day of life. Ultrasound and intravenous pyelography confirmed a hydronephrotic right kidney and obstructive megaureter after Pena. In the fifth month of life, the ureter was tapered and reimplanted. Six months later, posterior sagittal anorectoplasty was performed. In the sewentheenth month of life the colostomy was closed. This child attained normal growth and development, normal bowel control, fecal continence without soiling, obstipation and urinary infections.

  1. Clinical presentation of minimally invasive and in situ squamous cell carcinoma of the anus in homosexual men.

    Science.gov (United States)

    Forti, R L; Medwell, S J; Aboulafia, D M; Surawicz, C M; Spach, D H

    1995-09-01

    From January 1988 to December 1993, we identified six men with minimally invasive (stage I) squamous cell carcinoma of the anus and 10 men with anal carcinoma in situ (CIS). Of the six patients with invasive carcinoma, four were infected with human immunodeficiency virus (HIV), including one with AIDS. Of the 10 patients with CIS, eight were infected with HIV, including four with AIDS. Anal pain and bleeding were the most common symptoms of minimally invasive anal cancer and anal CIS. Anal irritation, burning, or pruritus occurred more frequently in patients with CIS, whereas anal ulcers, masses, or abscesses were more frequent in patients with minimally invasive cancer. Several patients with CIS had a discrete area of leukoplakia in the anal canal or a pigmented plaque of the anus and anal canal. These lesions were not observed in patients with minimally invasive anal cancer. The symptoms and signs of early-stage anal cancer in men at risk for developing HIV infection or men infected with HIV often resemble those of other common anorectal diseases in homosexual men. Anal cancer in HIV-infected men is not limited to those individuals with AIDS. PMID:8527551

  2. Perinatal outcomes and anomalies associated with fetal right aortic arch

    Directory of Open Access Journals (Sweden)

    Ahmet Gül

    2012-09-01

    Full Text Available Objective: To evaluate the prenatal findings, associated anomalies, and prognosis of right aortic arch (RAA anomalies. Material and Methods: All cases referred for detailed ultrasonography and fetal echocardiography between October 2006 and July 2009 were systematically examined for aortic arch anomalies and associated cardiac and extracardiac anomalies. Prenatal findings of all cases with aortic arch anomalies and intracardiac and extracardiac findings were prospectively registered in an electronic database that included fetal echocardiography. Outcomes of the cases were collected postnatally from the patients’ obstetricians, neonatal unit archieves, and pediatric cardiologists. Results: We detected 12 cases of RAA (0.37%; n=12/3200. Mean gestational age at diagnosis was 24 weeks (range, 21–33 weeks. Of the 12 cases of RAA, five (41.7% had a major cardiac defect, including tetralogy of Fallot (n= 3, atrioventricular septal defect (n=1, and ventricular septal defect (n=1. An extracardiac anomaly was observed in three cases (25%. The fetal karyotype was trisomy 21 in one case with increased nuchal translucency (6.6 mm. Microdeletion 22q11 analyses performed in three cases were normal. The postnatal courses of the cases with isolated RAA were uneventful. Two cases associated with major cardiac and extracardiac anomalies were lost in the early neonatal period. The case of trisomy 21 was terminated. The other four cases of RAA with an associated cardiac anomaly are currently in follow up. Conclusion: Aortic arch anomalies, particularly RAA, can be diagnosed by fetal echocardiography. The prognosis for isolated RAA is relatively good compared with that for RAA with associated anomalies.

  3. Chiral anomalies and differential geometry

    Energy Technology Data Exchange (ETDEWEB)

    Zumino, B.

    1983-10-01

    Some properties of chiral anomalies are described from a geometric point of view. Topics include chiral anomalies and differential forms, transformation properties of the anomalies, identification and use of the anomalies, and normalization of the anomalies. 22 references. (WHK)

  4. Neonate with VACTERL Association and a Branchial Arch Anomaly without Hydrocephalus.

    Science.gov (United States)

    Velazquez, Danitza; Pereira, Elaine; Havranek, Thomas

    2016-03-01

    VACTERL (vertebral anomalies, anal atresia, cardiac defect, tracheoesophageal fistula, renal anomaly, limb anomalies) is an association of anomalies with a wide spectrum of phenotypic expression. While the majority of cases are sporadic, there is evidence of an inherited component in a small number of patients as well as the potential influence of nongenetic risk factors (maternal diabetes mellitus). Presence of hydrocephalus has been reported in VACTERL patients (VACTERL-H) in the past, with some displaying branchial arch anomalies. We report the unique case of an infant of diabetic mother with VACTERL association and a branchial arch anomaly-in the absence of hydrocephalus. PMID:26929876

  5. PHACE Syndrome: Persistent Fetal Vascular Anomalies: A Case Report

    OpenAIRE

    Prochazka, V.; Hrbac, T.; Chmelova, J.; Skoloudik, D.; Prochazka, M

    2005-01-01

    PHACE(S) syndrome is an acronym for neurocutaneous disease encompassing the expression of (P) posterior cranial fossa malformations, (H) facial haemangiomas, (A) arterial anomalies, (C) aortic coarctaion and other cardiac defects, (E) eye abnormalities and (S) for sternal malformation or stenotic arterial diseases. We report on a case of PHACE syndrome complete expression with persistent fetal vascular anomalies unusually in a 55-year-old women with large bilateral facial and neck haemangioma...

  6. Ventriculomegaly with non-CNS anomalies

    International Nuclear Information System (INIS)

    We correlated fetal magnetic resonance (MR) imaging findings with postnatal clinical findings to assess ventriculomegaly with non-CNS anomalies. From 2002 to 2010, 52 fetuses underwent a MRI for evaluation of ventriculomegaly after ultrasonography (US). Ten of the 52 demonstrated anomalies outside the central nervous system (CNS), including trisomy 8, trisomy 18, X-linked hydrocephalus, CHARGE/Potter sequences, VATER association, oral-facial-digital syndrome, esophageal atresia type C, or external auditory canal stenosis. Examinations were performed between 24 and 35 weeks' gestation. MR imaging was performed in a 1.5-tesla unit using a phased-array coil without preparation. Fetal MR imaging showed abnormalities of the kidney, bladder, duodenum, and thumbs but did not permit diagnosis of esophageal atresia type C or craniofacial, anorectal, or skeletal anomalies. Cardiac anomaly was most frequent, but fetal MR imaging did not allow final diagnosis of congenital heart disease. On both US and MR imaging, esophageal atresia type C and anorectal anomaly were undetected; normal rectal signal in a case of anorectal anomaly without urorectal fistula did not lead to suspicion of anomaly. Observation of adducted thumbs on MR imaging is an important sign of X-linked hydrocephalus. The slice area used in this study did not cover polydactyly, which accompanies oral-facial-digital syndrome. US and MR imaging are complementary imaging methods used to evaluate ventriculomegaly. Fetal MR imaging should cover the kidney, bladder, and fingers. Further work is needed to determine the anomalies that can be clearly detected by fetal MR imaging. (author)

  7. A COMPARATIVE STUDY OF PEDIATRIC CARDIAC CATHETERIZATION PROCEDURE UNDER GENERAL ANESTHESIA WITH OR WITHOUT FEMORAL NERVE BLOCK

    OpenAIRE

    Jigisha; Bhavesh; Parineeta; Tarun

    2016-01-01

    OBJECTIVE Anesthetic management for interventional cardiac procedures/cardiac catheterization in pediatric patients is challenging. Cardiac anomalies vary from simple to complex congenital cardiac anomalies, shunts may be present at multiple levels and patients may be profoundly cyanotic, may be with ventricular dysfunction. They usually require sedation and analgesia to maintain steady stable state. In adults, such type of procedures can be well managed with local anesthesia....

  8. 77. Ultrasonography assessment of congenital renal anomalies in children with congenital heart diseases

    OpenAIRE

    M.H. Hamadah; Kabbani, M; M.A. Faraji

    2016-01-01

    Ultrasound (US) assessment of renal anomalies in children requiring pediatric cardiac surgery is not a standard practice. This study aimed to study the role of bedside US performed by intensivists to detect occult renal anomalies associated with congenital heart disease (CHD). Prospective descriptive study for 100 consecutive children with CHD admitted to Pediatric Cardiac Intensive Care Unit (PCICU) from Januarry 1st, 2015 through June, July 2015. Ultrasound of kidneys was performed initiall...

  9. Conformal Anomalies in Hydrodynamics

    CERN Document Server

    Eling, Christopher; Theisen, Stefan; Yankielowicz, Shimon

    2013-01-01

    We study the effect of conformal anomalies on the hydrodynamic description of conformal field theories in four spacetime dimensions. We consider equilibrium curved backgrounds characterized by a time-like Killing vector and construct a local low energy effective action that captures the conformal anomalies. Using as a special background the Rindler spacetime we derive a formula for the effect of the anomaly on the hydrodynamic pressure.

  10. Familial Poland anomaly.

    OpenAIRE

    David, T J

    1982-01-01

    The Poland anomaly is usually a non-genetic malformation syndrome. This paper reports two second cousins who both had a typical left sided Poland anomaly, and this constitutes the first recorded case of this condition affecting more than one member of a family. Despite this, for the purposes of genetic counselling, the Poland anomaly can be regarded as a sporadic condition with an extremely low recurrence risk.

  11. Timing Anomalies Reloaded

    OpenAIRE

    Gebhard, Gernot

    2010-01-01

    Computing tight WCET bounds in the presence of timing anomalies - found in almost any modern hardware architecture - is a major challenge of timing analysis. In this paper, we renew the discussion about timing anomalies, demonstrating that even simple hardware architectures are prone to timing anomalies. We furthermore complete the list of timing-anomalous cache replacement policies, proving that the most-recently-used replacement policy (MRU) also exhibits a domino effect.

  12. Network Traffic Anomaly Detection

    OpenAIRE

    Huang, Hong; Al-Azzawi, Hussein; Brani, Hajar

    2014-01-01

    This paper presents a tutorial for network anomaly detection, focusing on non-signature-based approaches. Network traffic anomalies are unusual and significant changes in the traffic of a network. Networks play an important role in today's social and economic infrastructures. The security of the network becomes crucial, and network traffic anomaly detection constitutes an important part of network security. In this paper, we present three major approaches to non-signature-based network detect...

  13. Hepatic and postrenal segment anomalies of inferior vena cava

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Yeon Hyeon; Park, Jae Hyung; Yeon, Kyung Mo; Han, Man Chung [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    1986-06-15

    Postrenal segment anomalies of inferior vena cava such as bilateral inferior vena cava and left-sided inferior vena cava can simulate lymphadenopathy on CT scan and these anomalous veins need consideration in retroperitoneal operations such as procedures for prevention of venous embolism, splenorenal shunt operation and aortic prosthetic replacement. Retrocaval ureter is a rare cause of obstructive uropathy or medical deviation of ureter. We analyzed 16 cases of postrenal segment anomalies diagnosed by CT, vena cavography, retrograde pyelography and ultrasonography including six rare positional anomalies at hepatic segment of inferior vena cava diagnosed by cardiac angiography. The results were as follows. 1. Postrenal segment anomalies were 6 cases of bilateral IVC, 8 cases of left-sided IVC and 2 cases of retrocaval ureters. On CT scan, 3 cases of bilateral IVC and 4 cases of left-sided IVC were accompanied by malignant tumors, but caval veins could be discriminated from enlarged nodes because of continuous tubular nature of vein on consecutive sections with homogeneous strong enhancement. Two cases of retrocaval ureters showed hydroureteronephrosis due to ureteral compression by IVC. 2. Hepatic segment anomalies were 6 cases. Five cases of IVC on left side of vertebra crossed midline at live to enter right-sided right atrium and one case of IVC on right side crossed midline to enter left-sided right atrium. Four cases of complex cardiac anomalies, 4 cases of annapolis and 2 cases of situs ambiguous were associated with these anomalies.

  14. Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome

    OpenAIRE

    Masuda, Koji; Akiyama, Kazuhiro; Arakawa, Michiko; Nishi, Eriko; Kitazawa, Noritaka; Higuchi, Tsukasa; Katou, Yuki; Shirahige, Katsuhiko; Izumi, Kosuke

    2015-01-01

    Rubinstein-Taybi syndrome (RSTS) is a multisystem developmental disorder characterized by facial dysmorphisms, broad thumbs and halluces, growth retardation, and intellectual disability. In about 8% of RSTS cases, mutations are found in EP300. Previously, the EP300 mutation has been shown to cause the highly variable RSTS phenotype. Using exome sequencing, we identified a de novo EP300 frameshift mutation in a proband with coloboma, facial asymmetry and imperforate anus with minimal RSTS feat...

  15. Vesicostomy and Colostomy in a Premature Neonate With Posterior Urethral Valves, Bilateral Dysplastic Kidneys, and High Imperforate Anus: The Challenge of Stoma Placement.

    Science.gov (United States)

    McGrath, Melissa; Alnaqi, Amar A A; Braga, Luis H

    2016-07-01

    Although anorectal malformations are often associated with urinary tract abnormalities, the association with posterior urethral valves is exceptionally rare. We report a unique case of a premature (35 gestational weeks) male neonate born with posterior urethral valves, bilateral dysplastic kidneys, and imperforate anus, successfully treated by Blocksom vesicostomy and left upper quadrant loop colostomy. The challenges involving placement of both stomas in a small abdominal wall of a 2200 g premature neonate are discussed. PMID:27015939

  16. Competing Orders and Anomalies

    Science.gov (United States)

    Moon, Eun-Gook

    2016-08-01

    A conservation law is one of the most fundamental properties in nature, but a certain class of conservation “laws” could be spoiled by intrinsic quantum mechanical effects, so-called quantum anomalies. Profound properties of the anomalies have deepened our understanding in quantum many body systems. Here, we investigate quantum anomaly effects in quantum phase transitions between competing orders and striking consequences of their presence. We explicitly calculate topological nature of anomalies of non-linear sigma models (NLSMs) with the Wess-Zumino-Witten (WZW) terms. The non-perturbative nature is directly related with the ’t Hooft anomaly matching condition: anomalies are conserved in renormalization group flow. By applying the matching condition, we show massless excitations are enforced by the anomalies in a whole phase diagram in sharp contrast to the case of the Landau-Ginzburg-Wilson theory which only has massive excitations in symmetric phases. Furthermore, we find non-perturbative criteria to characterize quantum phase transitions between competing orders. For example, in 4D, we show the two competing order parameter theories, CP(1) and the NLSM with WZW, describe different universality class. Physical realizations and experimental implication of the anomalies are also discussed.

  17. Anomalies and topology

    International Nuclear Information System (INIS)

    The lectures given cover the topological effects in gauge field theories, fermionic chiral anomalies, and some relationships between the two. Gauge field theories in three and four space-time dimensions are considered. Topological terms as external U(1) functional gauge potential connections in field space are discussed. Both the structure and physical impact of anomalies are described. 17 refs

  18. Anomalies from Immersions

    CERN Document Server

    Ospina, J F

    2001-01-01

    Two forms of anomalies for chiral spinors living on submanifolds of the spacetime are obtained from the integrality theorem for immersions. The first form of the chiral anomaly is the usual for chiral spinors living on D-brane and O-plane intersections, the second form is exotic.

  19. Coronary sinus type atrial septal defect in a child with pulmonary atresia and Ebstein's anomaly.

    OpenAIRE

    Russell, G A; Stovin, P G

    1985-01-01

    At birth an infant was found to have an unusual series of abnormalities with a coronary sinus type atrial septal defect complicating pulmonary atresia with an intact ventricular septum and Ebstein's anomaly. The functionally important anomalies were diagnosed by echocardiography and cardiac catheterisation. The coronary sinus defect and Ebstein's anomaly were detected only at necropsy. Although only a single case, the features of this heart favour Bull's revised classification of pulmonary at...

  20. [Rhythm disorders and cardiac crypto-malformations].

    Science.gov (United States)

    Davy, J M; Raczka, F; Cung, T T; Combes, N; Bortone, A; Gaty, D

    2005-12-01

    Faced with a cardiac arrhythmia occuring in an apparently healthy heart, it is necessary to perform an anatomical investigation to detect any unsuspected anomalies. Congenital cardiopathy must certainly be excluded, as this is often responsible for rhythm disorders and/or cardiac conduction defects. Similarly, any acquired conditions, cardiomyopathy, or cardiac tumour must be sought. However, the possibility should always be considered of a minimal congenital malformation, which could be repsonsible for: any type of cardiac arrhythmia: rhythm disorder or conduction defect at the atrial, junctional or ventricular level, with a benign or serious prognosis. Unexpected therapeutic difficulties during radiofrequency ablation procedures or at implantation of pacemakers or defibrillators. Together with rhythm studies, the investigation of choice is high quality imaging, either the classic left or right angiography or the more modern cardiac CT or intracardiac mapping. PMID:16433240

  1. Causes of sudden cardiac death in athletes

    Directory of Open Access Journals (Sweden)

    Popović Dejana

    2007-01-01

    Full Text Available Introduction Sudden cardiac death in athletes is a growing problem, despite the huge existing knowledge in medicine and sports. Effects of vigorous physical activity In response to vigorous physical activity, the body undergoes profound morphologic and functional changes. These changes are usually healthy, but sometimes may gravitate to some cardiac diseases. But still, most sudden cardiac deaths are due to previous unknown diseases. Causes of sudden cardiac death The most common cause of sudden cardiac death in athletes is hypertrophic cardiomyopathy. Other reasons are congenital coronary artery anomalies, myocarditis, dilatative cardiomyopathy, arrhythmogenic cardiomyopathy of the right ventricle, sarcoidosis, mitral valve prolapse, aortic valve stenosis, atherosclerosis, long QT syndrome, and blunt impact to the chest. Conclusion Bearing in mind the above mentioned, more frequent physical examinations of athletes are recommended.

  2. Cardiac rehabilitation

    Science.gov (United States)

    ... attack or other heart problem. You might consider cardiac rehab if you have had: Heart attack Coronary heart disease (CHD) Heart failure Angina (chest pain) Heart or heart valve surgery Heart transplant Procedures such as angioplasty and stenting In some ...

  3. Cardiac Rehabilitation

    Science.gov (United States)

    Cardiac rehabilitation (rehab) is a medically supervised program to help people who have A heart attack Angioplasty or coronary artery bypass grafting for coronary heart disease A heart valve repair or replacement A ...

  4. Cardiac sarcoidosis

    OpenAIRE

    Costello BT; Nadel J.; Taylor AJ

    2016-01-01

    Benedict T Costello,1,2 James Nadel,3 Andrew J Taylor,1,21Department of Cardiovascular Medicine, The Alfred Hospital, 2Baker IDI Heart and Diabetes Research Institute, Melbourne, VIC, 3School of Medicine, University of Notre Dame, Sydney, NSW, Australia Abstract: Cardiac sarcoidosis is a rare but life-threatening condition, requiring a high degree of clinical suspicion and low threshold for investigation to make the diagnosis. The cardiac manifestations include heart failure, conducting syst...

  5. Anomalies on orbifolds

    Energy Technology Data Exchange (ETDEWEB)

    Arkani-Hamed, Nima; Cohen, Andrew G.; Georgi, Howard

    2001-03-16

    We discuss the form of the chiral anomaly on an S1/Z2 orbifold with chiral boundary conditions. We find that the 4-divergence of the higher-dimensional current evaluated at a given point in the extra dimension is proportional to the probability of finding the chiral zero mode there. Nevertheless the anomaly, appropriately defined as the five dimensional divergence of the current, lives entirely on the orbifold fixed planes and is independent of the shape of the zero mode. Therefore long distance four dimensional anomaly cancellation ensures the consistency of the higher dimensional orbifold theory.

  6. Theoretically Optimal Distributed Anomaly Detection

    Data.gov (United States)

    National Aeronautics and Space Administration — A novel general framework for distributed anomaly detection with theoretical performance guarantees is proposed. Our algorithmic approach combines existing anomaly...

  7. Learning about Poland Anomaly

    Science.gov (United States)

    ... performed too early, while the individual is growing, asymmetry can result or be made greater than before. ... Anomaly About.com- Poland Syndrome [rarediseases.about.com] Information about Poland syndrome produced by Mary Kugler, M.S. ...

  8. Anomalies and tadpoles

    International Nuclear Information System (INIS)

    We show that massless RR tadpoles in vacuum configurations with open and unoriented strings are always related to anomalies. RR tadpoles arising from sectors of the internal SCFT with non-vanishing Witten index are in one-to-one correspondence with conventional irreducible anomalies. The anomalous content of the remaining RR tadpoles can be disclosed by considering anomalous amplitudes with higher numbers of external legs. We then provide an explicit parametrization of the anomaly polynomial in terms of the boundary reflection coefficients, i.e. one-point functions of massless RR fields on the disk. After factorization of the reducible anomaly, we extract the relevant WZ couplings in the effective lagrangians. (author)

  9. Anomaly Detection in Sequences

    Data.gov (United States)

    National Aeronautics and Space Administration — We present a set of novel algorithms which we call sequenceMiner, that detect and characterize anomalies in large sets of high-dimensional symbol sequences that...

  10. Skyrmions and anomalies

    International Nuclear Information System (INIS)

    The author summarizes the works presented at the meeting on skyrmions and anomalies. He divides the principal issues of this workshop into five categories: QCD effective lagrangians, chiral bags and the Cheshire cat principle, strangeness problem, phenomenology, mathematical structure

  11. Neutrino anomalies without oscillations

    Indian Academy of Sciences (India)

    Sandip Pakvasa

    2000-01-01

    I review explanations for the three neutrino anomalies (solar, atmospheric and LSND) which go beyond the `conventional' neutrino oscillations induced by mass-mixing. Several of these require non-zero neutrino masses as well.

  12. Anomalies and entanglement entropy

    OpenAIRE

    Nishioka, Tatsuma; Yarom, Amos(Department of Physics, Technion, Haifa, 32000, Israel)

    2016-01-01

    We initiate a systematic study of entanglement and Renyi entropies in the presence of gauge and gravitational anomalies in even-dimensional quantum field theories. We argue that the mixed and gravitational anomalies are sensitive to boosts and obtain a closed form expression for their behavior under such transformations. Explicit constructions exhibiting the dependence of entanglement entropy on boosts is provided for theories on spacetimes with non-trivial magnetic fluxes and (or) non-vanish...

  13. Congenital laryngeal anomalies,

    OpenAIRE

    Rutter, Michael J.

    2014-01-01

    Introduction: It is essential for clinicians to understand issues relevant to the airway management of infants and to be cognizant of the fact that infants with congenital laryngeal anomalies are at particular risk for an unstable airway. Objectives: To familiarize clinicians with issues relevant to the airway management of infants and to present a succinct description of the diagnosis and management of an array of congenital laryngeal anomalies. Methods: Revision article, in which the ma...

  14. The Pioneer Anomaly

    CERN Document Server

    de Diego, Jose A

    2008-01-01

    Analysis of the radio-metric data from Pioneer 10 and 11 spacecrafts has indicated the presence of an unmodeled acceleration starting at 20 AU, which has become known as the Pioneer anomaly. The nature of this acceleration is uncertain. In this paper we give a description of the effect and review some relevant mechanisms proposed to explain the observed anomaly. We also discuss on some future projects to investigate this phenomenon.

  15. Anomalies and gravity

    CERN Document Server

    Mielke, E W

    2006-01-01

    Anomalies in Yang-Mills type gauge theories of gravity are reviewed. Particular attention is paid to the relation between the Dirac spin, the axial current j_5 and the non-covariant gauge spin C. Using diagrammatic techniques, we show that only generalizations of the U(1)- Pontrjagin four--form F^ F= dC arise in the chiral anomaly, even when coupled to gravity. Implications for Ashtekar's canonical approach to quantum gravity are discussed.

  16. Anomalies and gravity

    International Nuclear Information System (INIS)

    Anomalies in Yang-Mills type gauge theories of gravity are reviewed. Particular attention is paid to the relation between the Dirac spin, the axial current j5 and the non-covariant gauge spin C. Using diagrammatic techniques, we show that only generalizations of the U(1)- Pontrjagin four-form F and F = dC arise in the chiral anomaly, even when coupled to gravity. Implications for Ashtekar's canonical approach to quantum gravity are discussed

  17. Volume anomaly in ferrimagnetism

    OpenAIRE

    Pascard, H.; Globus, A.

    1981-01-01

    The volume anomaly ΔV/V due to the magnetic energy corresponding to the exchange interactions is experimentally determined for YIG. The experimental values (from 77 K to Tc) agree with the values deduced from the theoretical expression based on the Néel's theories of volume anomaly and of ferrimagnetism. These results are compared with those obtained by other authors on ferromagnetic and antiferromagnetic materials with localized magnetic moments : a reduced curve is obtained.

  18. Anomalies and Entanglement Entropy

    CERN Document Server

    Nishioka, Tatsuma

    2015-01-01

    We initiate a systematic study of entanglement and Renyi entropies in the presence of gauge and gravitational anomalies in even-dimensional quantum field theories. We argue that the mixed and gravitational anomalies are sensitive to boosts and obtain a closed form expression for their behavior under such transformations. Explicit constructions exhibiting the dependence of entanglement entropy on boosts is provided for theories on spacetimes with non-trivial magnetic fluxes and (or) non-vanishing Pontryagin classes.

  19. The Holographic Supercurrent Anomaly

    CERN Document Server

    Chaichian, Masud

    2004-01-01

    The \\gamma-trace anomaly of supersymmetry current in a supersymmetric gauge theory shares a superconformal anomaly multiplet with the chiral R-symmetry anomaly and the Weyl anomaly, and its holographic reproduction is a valuable test to the AdS/CFT correspondence conjecture. We investigate how the \\gamma-trace anomaly of the supersymmetry current of {\\cal N}=1 four-dimensional supersymmetric gauge theory in an {\\cal N}=1 conformal supergravity background can be extracted out from the ${\\cal N}=2$ gauged supergravity in five dimensions. It is shown that the reproduction of this super-Weyl anomaly originates from the following two facts: First the {\\cal N}=2 bulk supersymmetry transformation converts into {\\cal N}=1 superconformal transformation on the boundary, which consists of {\\cal N}=1 supersymmetry transformation and special conformal supersymmetry (or super-Weyl) transformation; second the supersymmetry variation of the bulk action of five-dimensional gauged supergravity is a total derivative. The non-co...

  20. The Holographic Weyl anomaly

    CERN Document Server

    Henningson, M; Henningson, Mans; Skenderis, Kostas

    1998-01-01

    We calculate the Weyl anomaly for conformal field theories that can be described via the adS/CFT correspondence. This entails regularizing the gravitational part of the corresponding supergravity action in a manner consistent with general covariance. Up to a constant, the anomaly only depends on the dimension d of the manifold on which the conformal field theory is defined. We present concrete expressions for the anomaly in the physically relevant cases d = 2, 4 and 6. In d = 2 we find for the central charge c = 3 l/ 2 G_N in agreement with considerations based on the asymptotic symmetry algebra of adS_3. In d = 4 the anomaly agrees precisely with that of the corresponding N = 4 superconformal SU(N) gauge theory. The result in d = 6 provides new information for the (0, 2) theory, since its Weyl anomaly has not been computed previously. The anomaly in this case grows as N^3, where N is the number of coincident M5 branes, and it vanishes for a Ricci-flat background.

  1. Cardiac echinococcosis

    Directory of Open Access Journals (Sweden)

    Ivanović-Krstić Branislava A.

    2002-01-01

    Full Text Available Cardiac hydatid disease is rare. We report on an uncommon hydatid cyst localized in the right ventricular wall, right atrial wall tricuspid valve left atrium and pericard. A 33-year-old woman was treated for cough, fever and chest pain. Cardiac echocardiograpic examination revealed a round tumor (5.8 x 4 cm in the right ventricular free wall and two smaller cysts behind that tumor. There were cysts in right atrial wall and tricuspidal valve as well. Serologic tests for hydatidosis were positive. Computed tomography finding was consistent with diagnosis of hydatid cyst in lungs and right hylar part. Surgical treatment was rejected due to great risk of cardiac perforation. Medical treatment with albendazole was unsuccessful and the patient died due to systemic hydatid involvement of the lungs, liver and central nervous system.

  2. Recurrent Abortion in a Patient with Ebstein Anomaly

    Directory of Open Access Journals (Sweden)

    Abdolmohammad Ranjbar

    2014-04-01

    Full Text Available Most maternal cardiac disease in Western societies is now congenital in origin. This relates to the significant improvements in congenital cardiac surgery during the last years. Some patients will present for the first time in pregnancy with symptoms and learn that they have congenital heart disease. So all patients should have a detailed evaluation and appropriate counseling before pregnancy. Ebstein anomaly is a rare and complex congenital heart disorder occurring in 1 per 200 000 live births and, first described by a German physician Wilhelm Ebstein in 1866 in a report titled, “Concerning a very rare case of insufficiency of the tricuspid valve caused by a congenital malformation. This anomaly accounts for 0.5%–0.7% of cases of congenital heart disease. The average life duration of patients with Ebstein's anomaly is 25–30 years. The malformation consists of apical displacement of the tricuspid valve with resultant regurgitation and enlargement of the right heart chambers, resulting in arrhythmias and heart failure. The common cardiac anomalies associated with the condition are atrial septal defect (ASD in 90% of patients, anatomic or functional tricuspid atresia in 30%, Wolff-Parkinson-White (WPW syndrome in 15% and less commonly ventricular septal defect (VSD, pulmonic stenosis or atresia and mitral valve prolapse. Survival into adulthood is common and patients present with cyanosis, dyspnea and palpitations.

  3. Colon, rectum and anus

    Institute of Scientific and Technical Information of China (English)

    1997-01-01

    970341 Serum concentration of hyaluronic acid in pa-tients with colorectal cancer. XU Hongwei(许洪卫), etal. Dept Surg, Changzheng Hosp, 2nd Milit Med Uniu,Shanghai, 200003. Chin J Dig 1996; 16(6): 329-331. Objective: To find Out the relationship of serumhyaluronic acid and colorectal cancer. Method: UsingELISA, serum concentration hyaluronic acid(HA)was

  4. Cancer of the Anus

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  5. 可分离式髌骨爪治疗髌骨下极骨折%Treatment of splintered anus perineum patella fractures with the separability patella claw

    Institute of Scientific and Technical Information of China (English)

    许安平

    2011-01-01

    目的 探讨可分离式髌骨爪治疗髌骨下极粉碎性骨折的临床应用和效果.方法 采用可分离式髌骨爪固定治疗髌骨粉碎性骨折45例,前正中切口、复位用可分离式髌骨爪固定及膝关节加压包扎3 d后行膝关节被动屈伸锻练.结果 随访10~37月平均20月,骨折愈合时间8~12周临床疗效优40例,良4例,中1例,功能恢复优良率97.8%疗效满意.结论 可分离式髌骨爪是治疗髌骨下极粉碎性骨折一种良好的固定方法.%Aim To observe the clinical curative effec:t of separability patella claw in treatment of splintered anus perineum patella fractures. Methods 45 cases of splintered anus perineuru patella fracture patients werer treated with median incision , reset, separability patella claw ,pressure dressing and passive flexion and extension ac:tivity after 3 days. Results 45 cases were followed up, of which 40 patients were excellent, better in 4 cases,medium in lcase , with the total effective rate of 97% . Conclusion It is a good way in treatment of splintered anus perineum patella fractures with separability patella claw.

  6. Cardiac sarcoidosis

    Science.gov (United States)

    Smedema, J.P.; Zondervan, P.E.; van Hagen, P.; ten Cate, F.J.; Bresser, P.; Doubell, A.F.; Pattynama, P.; Hoogsteden, H.C.; Balk, A.H.M.M.

    2002-01-01

    Sarcoidosis is a multi-system granulomatous disorder of unknown aetiology. Symptomatic cardiac involvement occurs in approximately 5% of patients. The prevalence of sarcoidosis in the Netherlands is unknown, but estimated to be approximately 20 per 100,000 population (3200 patients). We report on five patients who presented with different manifestations of cardiac sarcoidosis, and give a brief review on the current management of this condition. Magnetic Resonance Imaging (MRI) can be of great help in diagnosing this condition as well as in the follow-up of the response to therapy. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6 PMID:25696121

  7. Cardiac Pacemakers

    International Nuclear Information System (INIS)

    A complete survey of physiological biophysical,clinical and engineering aspects of cardiac facing,including the history and an assessment of possible future developments.Among the topics studied are: pacemakers, energy search, heart stimulating with pacemakers ,mathematical aspects of the electric cardio stimulation chronic, pacemaker implants,proceeding,treatment and control

  8. Identifying, characterizing, and classifying congenital anomalies of the coronary arteries.

    Science.gov (United States)

    Shriki, Jabi E; Shinbane, Jerold S; Rashid, Mollie A; Hindoyan, Antereas; Withey, James G; DeFrance, Anthony; Cunningham, Mark; Oliveira, George R; Warren, Bill H; Wilcox, Alison

    2012-01-01

    The clinical manifestations of coronary artery anomalies vary in severity, with some anomalies causing severe symptoms and cardiovascular sequelae and others being benign. Cardiovascular computed tomography (CT) has emerged as the standard of reference for identification and characterization of coronary artery anomalies. Therefore, it is important for the reader of cardiovascular CT images to be thoroughly familiar with the spectrum of coronary artery anomalies. Hemodynamically significant anomalies include atresia, origin from the pulmonary artery, interarterial course, and congenital fistula. Non-hemodynamically significant anomalies include duplication; high origin; a prepulmonic, transseptal, or retroaortic course; shepherd's crook right coronary artery; and systemic termination. In general, coronary arteries with an interarterial course are associated with an increased risk of sudden cardiac death. Coronary artery anomalies that result in shunting, including congenital fistula and origin from the pulmonary artery, are also commonly symptomatic and may cause steal of blood from the myocardium. Radiologists should be familiar with each specific variant and its specific constellation of potential implications. PMID:22411942

  9. Anomaly Extraction in Networks

    Directory of Open Access Journals (Sweden)

    Mr. Naushad Mujawar

    2014-03-01

    Full Text Available The application detects anomaly in network using techniques like histogram, cloning voting, filtering. To extract anomalous flows, one could build a model describing normal flow characteristics and use the model to identify deviating flows. We can compare flows of packets on network with previous flows, like new flows that were not previously observed or flows with significant increase/decrease in their volume. Identify an anomalous flow that combines and consolidates information from multiple histogram-based anomaly detectors [1] [4] [8]. Compared to other possible approaches. Build a histogram based detector that (i applies histogram cloning[1][4], i.e., maintains multiple randomized histograms to obtain additional views of network traffic[3]; and (ii uses the Kullback-Leibler (KL distance to detect anomalies.

  10. Congenital laryngeal anomalies,

    Directory of Open Access Journals (Sweden)

    Michael J. Rutter

    2014-12-01

    Full Text Available Introduction: It is essential for clinicians to understand issues relevant to the airway management of infants and to be cognizant of the fact that infants with congenital laryngeal anomalies are at particular risk for an unstable airway. Objectives: To familiarize clinicians with issues relevant to the airway management of infants and to present a succinct description of the diagnosis and management of an array of congenital laryngeal anomalies. Methods: Revision article, in which the main aspects concerning airway management of infants will be analyzed. Conclusions: It is critical for clinicians to understand issues relevant to the airway management of infants.

  11. Transanal Pull-Through Procedure with Delayed versus Immediate Coloanal Anastomosis for Anus-Preserving Curative Resection of Lower Rectal Cancer: A Case-Control Study.

    Science.gov (United States)

    Xiong, Yong; Huang, Ping; Ren, Qing-Gui

    2016-06-01

    This case-control study compared the effectiveness and safety of transanal pull-through procedure (TPP) with delayed or immediate coloanal anastomosis (CAA) for anus-preserving curative resection of lower rectal cancer. Lower rectal cancer patients (n = 128) were hospitalized between January 2003 and December 2013 for elective anus-preserving curative resection through a TPP with delayed (n = 72) or immediate (n = 56) CAA. Main outcome measures including surgical safety, resection radicality, and defecation function were assessed. The two groups were comparable in age, sex, gross pathology, histology, and tumor-node-metastasis staging. Both the delayed and immediate CAA TPPs had similar resection radicality and safety profiles. The immediate CAA was associated with a significantly higher risk of anastomotic leakage and defecation impairment. None of patients in the delayed CAA group experienced anastomotic leakage. In conclusion, TPP with delayed CAA may be superior to immediate CAA in minimizing the risk of anastomotic leakage and relevant surgical morbidities, and does not require a temporary ileostomy and second-look restoration of ostomy. PMID:27305886

  12. PHACE syndrome: MRI of intracerebral vascular anomalies and clinical findings in a series of 12 patients

    International Nuclear Information System (INIS)

    PHACE (posterior fossa defects, haemangioma, arterial anomalies, coarctation of the aorta and cardiac defects, eye abnormalities) syndrome describes a constellation of abnormalities that can occur in association with segmental craniofacial infantile haemangioma. To report the spectrum of clinical and imaging abnormalities seen in a cohort of children. A retrospective review of the clinical and imaging records of all patients diagnosed with PHACE syndrome between 1998 and 2009 was performed. Information sought included patient demographics, craniofacial segments involved, imaging findings and other extracutaneous abnormalities. Twelve patients were diagnosed with PHACE syndrome over 11 years. All patients had a segmental craniofacial haemangioma. Involved facial segments, in order of frequency, were frontotemporal (12), maxillary (8), mandibular (5) and frontonasal (1). The most common extracutaneous abnormalities were neurovascular anomalies (10), with many patients having multiple anomalies. The spectrum of arterial anomalies ranged from hypoplasia (9) to ectasia (3), anomalous origin/course (2) and persistent fetal anastomosis (2). Other anomalies found included cardiac anomalies (3), coarctation of the aorta (2), posterior fossa malformations (1) and sternal region anomalies (1). Intracranial anomalies are the most common extracutaneous feature of PHACE syndrome. The contribution of the radiologist in the recognition of such anomalies is important for the diagnosis of PHACE syndrome. (orig.)

  13. PHACE syndrome: MRI of intracerebral vascular anomalies and clinical findings in a series of 12 patients.

    LENUS (Irish Health Repository)

    Bracken, Jennifer

    2012-02-01

    BACKGROUND: PHACE (posterior fossa defects, haemangioma, arterial anomalies, coarctation of the aorta and cardiac defects, eye abnormalities) syndrome describes a constellation of abnormalities that can occur in association with segmental craniofacial infantile haemangioma. OBJECTIVE: To report the spectrum of clinical and imaging abnormalities seen in a cohort of children. MATERIALS AND METHODS: A retrospective review of the clinical and imaging records of all patients diagnosed with PHACE syndrome between 1998 and 2009 was performed. Information sought included patient demographics, craniofacial segments involved, imaging findings and other extracutaneous abnormalities. RESULTS: Twelve patients were diagnosed with PHACE syndrome over 11 years. All patients had a segmental craniofacial haemangioma. Involved facial segments, in order of frequency, were frontotemporal (12), maxillary (8), mandibular (5) and frontonasal (1). The most common extracutaneous abnormalities were neurovascular anomalies (10), with many patients having multiple anomalies. The spectrum of arterial anomalies ranged from hypoplasia (9) to ectasia (3), anomalous origin\\/course (2) and persistent fetal anastomosis (2). Other anomalies found included cardiac anomalies (3), coarctation of the aorta (2), posterior fossa malformations (1) and sternal region anomalies (1). CONCLUSION: Intracranial anomalies are the most common extracutaneous feature of PHACE syndrome. The contribution of the radiologist in the recognition of such anomalies is important for the diagnosis of PHACE syndrome.

  14. PHACE syndrome: MRI of intracerebral vascular anomalies and clinical findings in a series of 12 patients

    Energy Technology Data Exchange (ETDEWEB)

    Bracken, Jennifer; Robinson, Ian; Snow, Aisling; Rea, David; Phelan, Ethna [Our Lady' s Children' s Hospital, Department of Radiology, Dublin (Ireland); Watson, Rosemarie; Irvine, Alan D. [Our Lady' s Children' s Hospital, Department of Dermatology, Dublin (Ireland)

    2011-09-15

    PHACE (posterior fossa defects, haemangioma, arterial anomalies, coarctation of the aorta and cardiac defects, eye abnormalities) syndrome describes a constellation of abnormalities that can occur in association with segmental craniofacial infantile haemangioma. To report the spectrum of clinical and imaging abnormalities seen in a cohort of children. A retrospective review of the clinical and imaging records of all patients diagnosed with PHACE syndrome between 1998 and 2009 was performed. Information sought included patient demographics, craniofacial segments involved, imaging findings and other extracutaneous abnormalities. Twelve patients were diagnosed with PHACE syndrome over 11 years. All patients had a segmental craniofacial haemangioma. Involved facial segments, in order of frequency, were frontotemporal (12), maxillary (8), mandibular (5) and frontonasal (1). The most common extracutaneous abnormalities were neurovascular anomalies (10), with many patients having multiple anomalies. The spectrum of arterial anomalies ranged from hypoplasia (9) to ectasia (3), anomalous origin/course (2) and persistent fetal anastomosis (2). Other anomalies found included cardiac anomalies (3), coarctation of the aorta (2), posterior fossa malformations (1) and sternal region anomalies (1). Intracranial anomalies are the most common extracutaneous feature of PHACE syndrome. The contribution of the radiologist in the recognition of such anomalies is important for the diagnosis of PHACE syndrome. (orig.)

  15. Cohomology and Topological Anomalies

    CERN Document Server

    Ekstrand, C

    2001-01-01

    The chiral anomaly can be considered as an object defined either on the space of gauge potentials or on the orbit space. We will discuss the relation between the two descriptions. We will also relate to the cohomology of the group of gauge transformations.

  16. Cohomology and Topological Anomalies

    OpenAIRE

    Ekstrand, Christian

    2000-01-01

    The chiral anomaly can be considered as an object defined either on the space of gauge potentials or on the orbit space. We will discuss the relation between the two descriptions. We will also relate to the cohomology of the group of gauge transformations.

  17. Bolivian Bouguer Anomaly Grid

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A 1 kilometer Bouguer anomaly grid for the country of Bolivia.Number of columns is 550 and number of rows is 900. The order of the data is from the lower left to...

  18. Anomaly Busters II

    International Nuclear Information System (INIS)

    The anomaly busters had struck on the first day of the Kyoto meeting with Yoji Totsuka of Tokyo speaking on baryon number nonjjonservation and 'related topics'. The unstable proton is a vital test of grand unified pictures pulling together the electroweak and quark/gluon forces in a single field theory

  19. Anomalies and elliptic operators

    International Nuclear Information System (INIS)

    The coefficients of asymptotic expansion Spexp(-tA) at t→0 are calculated for the quantum field theory operators. It is shown how to apply these results to the calculations of axial and conformal anomalies, the charge renormalization in gauge theory and effective action in twodimensional electrodynamics

  20. North Atlantic Temperature Anomaly

    OpenAIRE

    Vukcevic, M.A.

    2009-01-01

    The author postulates the existence of a high correlation between North Atlantic Temperature Anomaly and the variations of magnetic field over the Hudson Bay region. Post-glacial uplift and convection in the underlying mantle uplift (as reflected in changes of the area's magnetic intensity) are making significant contribution to the Atlantic basin climate change.

  1. Cardiac rhabdomyosarcoma

    OpenAIRE

    Chlumský, Jaromír; Holá, Dana; Hlaváček, Karel; Michal, Michal; Švec, Alexander; Špatenka, Jaroslav; Dušek, Jan

    2001-01-01

    Cardiac sarcoma is a very rare neoplasm and is difficult to diagnose. The case of a 51-year-old man with a left atrial tumour, locally recurrent three months after its surgical removal, is presented. Computed tomography showed metastatic spread to the lung parenchyma. On revised histology, the mass extirpated was a sarcoma. Because of the metastatic spread, further therapy was symptomatic only; the patient died 15 months after the first manifestation of his problems. Immunohistochemical stain...

  2. Cardiac Calcification

    Directory of Open Access Journals (Sweden)

    Morteza Joorabian

    2011-05-01

    Full Text Available There is a spectrum of different types of cardiac"ncalcifications with the importance and significance"nof each type of cardiac calcification, especially"ncoronary artery calcification. Radiologic detection of"ncalcifications within the heart is quite common. The"namount of coronary artery calcification correlates"nwith the severity of coronary artery disease (CAD."nCalcification of the aortic or mitral valve may indicate"nhemodynamically significant valvular stenosis."nMyocardial calcification is a sign of prior infarction,"nwhile pericardial calcification is strongly associated"nwith constrictive pericarditis. A spectrum of different"ntypes of cardiac calcifications (linear, annular,"ncurvilinear,... could be seen in chest radiography and"nother imaging modalities. So a carful inspection for"ndetection and reorganization of these calcifications"nshould be necessary. Numerous modalities exist for"nidentifying coronary calcification, including plain"nradiography, fluoroscopy, intravascular ultrasound,"nMRI, echocardiography, and conventional, helical and"nelectron-beam CT (EBCT. Coronary calcifications"ndetected on EBCT or helical CT can be quantifie,"nand a total calcification score (Cardiac Calcification"nScoring may be calculated. In an asymptomatic"npopulation and/or patients with concomitant risk"nfactors like diabetes mellitus, determination of the"npresence of coronary calcifications identifies the"npatients at risk for future myocardial infarction and"ncoronary artery disease. In patients without coronary"ncalcifications, future cardiovascular events could"nbe excluded. Therefore, detecting and recognizing"ncalcification related to the heart on chest radiography"nand other imaging modalities such as fluoroscopy, CT"nand echocardiography may have important clinical"nimplications.

  3. Chiral anomaly on a lattice

    CERN Document Server

    Mickelsson, J

    1996-01-01

    A calculation of the chiral anomaly on a finite lattice without fermion doubling is presented . The lattice gauge field is defined in the spirit of noncommutative geometry. Standard formulas for the continuum anomaly are obtained as a limit.

  4. Urinary System anomalies at birth

    OpenAIRE

    Sharada B. Menasinkai; Mahantappa A. Chiniwar; Saraswathi, G

    2015-01-01

    Background: Congenital anomalies of urinary system are common and are found in 3-4% of population, and lethal urinary anomalies account for 10% of termination of pregnancy. Methods: A study was done to know the incidence of congenital anomalies at birth for the period of 4 months from May 99 - Sept 99 at Cheluvamba hospital attached to Mysore medical college. Congenital anomalies in the still births, live births and aborted fetuses >20 weeks were studied along with the case history and ul...

  5. Current commutator anomalies and chiral anomalies in the canonical formalism

    International Nuclear Information System (INIS)

    Without recourse to the Bjorken-Johnson-Low (BJL) method, current-current and current-electric-field commutator anomalies are evaluated in chiral gauge theories in two- and four-dimensional spacetime with the help of a gauge covariant regularization method. The results are consistent with previous analyses through the BJL method, and partially confirmed Faddeev's conjecture on the commutator anomalies of the Gauss law constraint operators within the canonical formalism. The chiral anomalies of the current divergence are derived from these commutator anomalies in the Weyl gauge where current-electric-field commutator anomalies play important roles

  6. Anomaly-safe discrete groups

    International Nuclear Information System (INIS)

    We show that there is a class of finite groups, the so-called perfect groups, which cannot exhibit anomalies. This implies that all non-Abelian finite simple groups are anomaly-free. On the other hand, non-perfect groups generically suffer from anomalies. We present two different ways that allow one to understand these statements

  7. Anomalies and developmental defects

    International Nuclear Information System (INIS)

    Amonalies and developmental defects in trachea and bronchi (tracheal bronch us, diverticulum of trachea or bronchus, defects due to atresia of bronchial tre e, tracheobronchomegaly), lung vessels (aneurisms of pulmonary artery, agenesia, aplasia and hypoplasia of pulmonary artery,anomalies of pulmonary veins, varico sis of pulmonary veins), pulmonary tissue (lung sequestration, congenital lobar pulmonary emphysema, essential hemosiderosis), have beendescribed. The problems of the diagnosis of the above-mentioned diseases using roentgenograms are consid ered

  8. Anomalies, Branes, and Currents

    OpenAIRE

    Cheung, Yeuk-Kwan E.; Yin, Zheng

    1997-01-01

    When a D-brane wraps around a cycle of a curved manifold, the twisting of its normal bundle can induce chiral asymmetry in its worldvolume theory. We obtain the general form of the resulting anomalies for D-branes and their intersections. They are not cancelled among themselves, and the standard inflow mechanism does not apply at first sight because of their apparent lack of factorizability and the apparent vanishing of the corresponding inflow. We show however after taking into consideration...

  9. Cardiac conduction system

    Science.gov (United States)

    The cardiac conduction system is a group of specialized cardiac muscle cells in the walls of the heart that send signals ... to contract. The main components of the cardiac conduction system are the SA node, AV node, bundle ...

  10. Congenital cardiac defect in a pygmy goat (Capra hircus)

    OpenAIRE

    Laus, Fulvio; COPPONI, Ilenia; Cerquetella, Matteo; FRUGANTI, Alessandro

    2011-01-01

    Congenital cardiac defects are anatomic conditions present at birth. Few references to such conditions in goats are available in the current scientific literature. This report describes, for the first time, a congenital cardiac disease clinically characterized by polypnea from birth and exercise intolerance in a 2-month-old pygmy goat. An atrioventricular dysplasia known as Ebstein's anomaly, an atrial septal defect, and a mild subaortic stenosis were ultrasonographically diagnosed.

  11. Cardiac ultrasonography in structural abnormalities and arrhythmias. Recognition and treatment.

    OpenAIRE

    Brook, M. M.; Silverman, N H; Villegas, M.

    1993-01-01

    Fetal cardiac ultrasonography has become an important tool in the evaluation of fetuses at risk for cardiac anomalies. It can both guide prenatal treatment and assist the management and timing of delivery. We recommend that a fetal echocardiogram be done when there is a family history of congenital heart disease; maternal disease that may affect the fetus; a history of maternal drug use, either therapeutic or illegal; evidence of other fetal abnormalities; or evidence of fetal hydrops. The op...

  12. The Pioneer Anomaly

    CERN Document Server

    Turyshev, Slava G

    2010-01-01

    Radio-metric Doppler tracking data received from the Pioneer 10 and 11 spacecraft from heliocentric distances of 20-70 AU has consistently indicated the presence of a small, anomalous, blue-shifted frequency drift uniformly changing with a rate of ~6 x 10^{-9} Hz/s. Ultimately, the drift was interpreted as a constant sunward deceleration of each particular spacecraft at the level of a_P = (8.74 +/- 1.33) x 10^{-10} m/s^2. This apparent violation of the Newton's gravitational inverse-square law has become known as the Pioneer anomaly; the nature of this anomaly remains unexplained. In this review, we summarize the current knowledge of the physical properties of the discovered effect and the conditions that led to its detection and characterization. We review various mechanisms proposed to explain the anomaly and discuss the current state of efforts to determine its nature. A comprehensive new investigation of the anomalous behavior of the two Pioneers has begun recently. The new efforts rely on the much-extend...

  13. Double Coronary Artery Anomaly in an Elderly Asymptomatic Patient with Positive Electrocardiogram Stress Test

    OpenAIRE

    Giuseppe Cannavale; Fabiana Trulli; Marco Colotto

    2013-01-01

    Malignant coronary artery anomalies and myocardial bridging are more common findings in young patients with cardiac symptoms, but these two associated yet different types of anomalies in an elderly patient has been rarely described. The following case describes the diagnostic use of 128-slice coronary-computed tomography images of an 82-year-old male, former professional soccer player, who reached the age of 82 years without any symptoms of coronary heart disease. In this patient, an associat...

  14. Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome.

    Science.gov (United States)

    Masuda, Koji; Akiyama, Kazuhiro; Arakawa, Michiko; Nishi, Eriko; Kitazawa, Noritaka; Higuchi, Tsukasa; Katou, Yuki; Shirahige, Katsuhiko; Izumi, Kosuke

    2015-07-01

    Rubinstein-Taybi syndrome (RSTS) is a multisystem developmental disorder characterized by facial dysmorphisms, broad thumbs and halluces, growth retardation, and intellectual disability. In about 8% of RSTS cases, mutations are found in EP300. Previously, the EP300 mutation has been shown to cause the highly variable RSTS phenotype. Using exome sequencing, we identified a de novo EP300 frameshift mutation in a proband with coloboma, facial asymmetry and imperforate anus with minimal RSTS features. Previous molecular studies have demonstrated the importance of EP300 in oculogenesis, supporting the possibility that EP300 mutation may cause ocular coloboma. Since a wide phenotypic spectrum is well known in EP300-associated RSTS cases, the atypical phenotype identified in our proband may be an example of rare manifestations of RSTS. PMID:26279656

  15. 女婴直肠前庭瘘的病因探讨%Etiology of Rectevestibular Fistula with Normal Anus in Female Infants

    Institute of Scientific and Technical Information of China (English)

    张丽丽; 张学衡

    1991-01-01

    本文报告8例正常肛门伴直肠前庭瘘的女婴,作者以临床及病理分析为主,辅以其它有关检查,对本病病因进行了探讨.指出此病发病较早,可有腰骶椎隐裂等伴发畸形,瘘管切片观察见有平滑肌存在.认为此病病因是先天性的.%Eight cases of rectovestibular fistula with normal anus are presented.A preliminary study on etiology was made mainly by the clinical and pathological findings.Because of its early onset,the accompanying spina bifida,and the presence of smooth muscle in the fistula tissue,the disease is considered congenital in origin.

  16. Global anomalies in six dimensions

    International Nuclear Information System (INIS)

    Applying Witten's formula for global gauge and gravitational anomalies to six dimensional supergravities, we find: (a) The perturbatively anomaly free N=4 chiral supergravity coupled to 21 tensor multiplets is global anomaly free for any choice of space-time manifold with vanishing third Betti number (b3). (b) The perturbatively anomaly free matter coupled N=2 chiral supergravities with arbitrary number of tensor multiplets, whose Yang-Mills gauge groups do not include G2, SU(2), or SU(3) are free of global anomalies if the theory is formulated on S6. In the case of 9 tensor multiplets coupled to supergravity this result holds for any spacetime with vanishing b3. (c) The N=6 chiral supergravity has perturbative gravitational anomalies, and therefore the global anomalies need not be considered in this case. (author)

  17. An ECG T-wave Anomalies Detection Using a Lightweight Classification Model for Wireless Body Sensors

    OpenAIRE

    Hadjem, Medina; Naït-Abdesselam, Farid

    2015-01-01

    International audience Various wearable devices are foreseen to be the key components in the future for vital signs monitoring as they offer a non-invasive, remote and real-time medical monitoring means. Among those, Wireless Body Sensors (WBS) for cardiac monitoring are of prominent help to early detect cardioVascular Diseases (CVD) by analyzing 24/24 and 7/7 collected cardiac data. Today, most of these WBS systems for CVD detection, includeonly limited automatic anomalies detection, part...

  18. Chiral supergravity and anomalies

    CERN Document Server

    Mielke, E W; Macias, Alfredo; Mielke, Eckehard W.

    1999-01-01

    Similarily as in the Ashtekar approach, the translational Chern-Simons term is, as a generating function, instrumental for a chiral reformulation of simple (N=1) supergravity. After applying the algebraic Cartan relation between spin and torsion, the resulting canonical transformation induces not only decomposition of the gravitational fields into selfdual and antiselfdual modes, but also a splitting of the Rarita-Schwinger fields into their chiral parts in a natural way. In some detail, we also analyze the consequences for axial and chiral anomalies.

  19. 经肛门拖出式先天性巨结肠根治术的临床实践研究%Clinical Study on Practice with Pulling out Through the Anus Hirschsprung

    Institute of Scientific and Technical Information of China (English)

    石毅军; 侯远发; 宋耀明

    2014-01-01

    目的:总结经肛门拖出式根治术治疗先天性巨结肠的临床疗效。方法:2011年6月~2012年6月我院共收治15例先天性巨结肠患者,通过经肛门拖出式根治术治疗,观察围手术期情况及术后随访情况。结果:15例均经肛门顺利完成先天性巨结肠根治的手术,术后出现3例并发症,随访发现,患儿逐渐恢复正常,Reding肛门评分明显增加。结论:经肛门拖出式先天性巨结肠根治术治疗先天性巨结肠效果明显,术后恢复快,治疗时间短,具有临床推广价值。%To Summary dragged through the anus type radical mastectomy Hirschsprung clinical efficacy.Methods:A retrospective analysis of our hospital approach in June 2011 to June 2012 included 15 cases between Hirschsprung patients to take through the anus drag-type radical mastectomy situation perioperative and postoperative follow-up situation.Results:15 cases were successfully completed through the anus surgery Hirschsprung's disease, three cases of postoperative complications, follow-up found that children gradually returned to normal,Reding anus score increased significantly.Conclusion:Pulling out through the anus treatment of Hirschsprung's disease Hirschsprung effect is obvious,rapid postoperative recovery,the treatment time is short, with a clinical value.

  20. Urinary System anomalies at birth

    Directory of Open Access Journals (Sweden)

    Sharada B. Menasinkai

    2015-06-01

    Full Text Available Background: Congenital anomalies of urinary system are common and are found in 3-4% of population, and lethal urinary anomalies account for 10% of termination of pregnancy. Methods: A study was done to know the incidence of congenital anomalies at birth for the period of 4 months from May 99 - Sept 99 at Cheluvamba hospital attached to Mysore medical college. Congenital anomalies in the still births, live births and aborted fetuses >20 weeks were studied along with the case history and ultrasound reports. Aborted fetuses and still born babies were collected for autopsy after the consent of parents. These babies were fixed in 10% formalin and autopsy was done after fixing, and anomalies were noted. Results: Total births during study period were 3000. There were 61 babies with congenital anomalies and 6 babies had anomalies of urinary system. Among the urinary system anomalies 1 baby had bilateral renal agenesis, 1 baby had unilateral renal agenesis with anophthalmia (Fraser syndrome, 2 babies had Multicystic dysplastic kidney disease (MCDK and 1 live baby had hydronephrosis due to obstruction at pelvi ureteric junction, and 1 live female baby had polycystic kidneys. Conclusion: Incidence of urinary system anomalies in the present study was 2 per 1000 births. U/S detection of urinary anomalies varies with period of gestation, amniotic fluid volume and visualisation of urinary bladder. Autopsy helps to detect renal agenesis. [Int J Res Med Sci 2015; 3(3.000: 743-748

  1. Cardiac MRI in Athletes

    NARCIS (Netherlands)

    Luijkx, T.

    2012-01-01

    Cardiac magnetic resonance imaging (CMR) is often used in athletes to image cardiac anatomy and function and is increasingly requested in the context of screening for pathology that can cause sudden cardiac death (SCD). In this thesis, patterns of cardiac adaptation to sports are investigated with C

  2. Trace anomaly driven inflation

    Science.gov (United States)

    Hawking, S. W.; Hertog, T.; Reall, H. S.

    2001-04-01

    This paper investigates Starobinsky's model of inflation driven by the trace anomaly of conformally coupled matter fields. This model does not suffer from the problem of contrived initial conditions that occurs in most models of inflation driven by a scalar field. The universe can be nucleated semiclassically by a cosmological instanton that is much larger than the Planck scale provided there are sufficiently many matter fields. There are two cosmological instantons: the four sphere and a new ``double bubble'' solution. This paper considers a universe nucleated by the four sphere. The AdS/CFT correspondence is used to calculate the correlation function for scalar and tensor metric perturbations during the ensuing de Sitter phase. The analytic structure of the scalar and tensor propagators is discussed in detail. Observational constraints on the model are discussed. Quantum loops of matter fields are shown to strongly suppress short scale metric perturbations, which implies that short distance modifications of gravity would probably not be observable in the cosmic microwave background. This is probably true for any model of inflation provided there are sufficiently many matter fields. This point is illustrated by a comparison of anomaly driven inflation in four dimensions and in a Randall-Sundrum brane-world model.

  3. Urogenital tract anomalies in children with congenital anorectal malformation

    OpenAIRE

    Hoekstra, J.W.

    1991-01-01

    textabstractThe term 'imperforate anus' covers a variety of congenital anorectal malformations ranging in severity from anal stenosis to cloacal exstrophy. The clinical picture of the anorectal malformation has been known for thousands of years, during which many attempts have been made to find an effective treatment. In the days of Assurbanipal, king of Assyria from 668 to 627 B.C., the library of Ninive contained a cuneiform tablet with a text about a child born without an anus (Scharli 197...

  4. Coronary anomalies in Pakistani children with tetralogy of fallot

    International Nuclear Information System (INIS)

    To determine coronary artery anomalies in tetralogy of Fallot in Pakistani children as seen on angiography. Study Design: Case series. Place and Duration of Study: The National Institute of Cardiovascular Diseases, Karachi, Pakistan from July 2006 to July 2007. Methodology: Children under 15 years of age with echocardiographic diagnosis of tetralogy of Fallot were included in the study. All patients had pre-operative cardiac catheterization and angiography. Coronary arteries were studied with a nonselective aortic root angiogram in standard cranially tilted left anterior oblique view. The frequency of a normal and an anomalous coronary was determined. Results: Of the 83 patients, 78% were male and had a mean age of 8.9 years. Their mean weight was 14.3 kilograms. Seventy six (91.6%) had a normal coronary anatomy while 7 (8.4%) patients had anomalous coronary arteries. Among the patients with coronary anomalies, the commonest was a single origin coronary artery in 04 (57.14%) cases. Three (42.86%) had an anomalous origin of left anterior descending artery from the right coronary artery. Conclusion: Coronary artery anomalies were detected in 8.4% of the cases with tetralogy of Fallot. Single origin coronary artery anomaly was the commonest anomaly. (author)

  5. Screening for proximal coronary artery anomalies with 3-dimensional MR coronary angiography

    OpenAIRE

    Prakken, Niek H.; Cramer, Maarten J; Olimulder, Marlon A; Agostoni, Pierfrancesco; Mali, Willem P; Velthuis, Birgitta K

    2010-01-01

    Under 35 years of age, 14% of sudden cardiac death in athletes is caused by a coronary artery anomaly (CAA). Free-breathing 3-dimensional magnetic resonance coronary angiography (3D-MRCA) has the potential to screen for CAA in athletes and non-athletes as an addition to a clinical cardiac MRI protocol. A 360 healthy men and women (207 athletes and 153 non-athletes) aged 18–60 years (mean age 31 ± 11 years, 37% women) underwent standard cardiac MRI with an additional 3D-MRCA within a maximum o...

  6. Observational manifestations of anomaly inflow

    OpenAIRE

    Boyarsky, Alexey; Ruchayskiy, Oleg; Shaposhnikov, Mikhail

    2005-01-01

    In theories with chiral couplings, one of the important consistency requirements is that of the cancellation of a gauge anomaly. In particular, this is one of the conditions imposed on the hypercharges in the standard model. However, anomaly cancellation condition of the standard model looks unnatural from the perspective of a theory with extra dimensions. Indeed, if our world were embedded into an odd-dimensional space, then the full theory would be automatically anomaly-free. In this paper ...

  7. What is a Timing Anomaly?

    DEFF Research Database (Denmark)

    Cassez, Franck; Hansen, Rene Rydhof; Olesen, Mads Chr.

    difficult. We examine previous definitions of timing anomalies, and identify examples where they do not align with common observations. We then provide a definition for consistently slower hardware traces that can be used to define timing anomalies and aligns with common observations.......Timing anomalies make worst-case execution time analysis much harder, because the analysis will have to consider all local choices. It has been widely recognised that certain hardware features are timing anomalous, while others are not. However, defining formally what a timing anomaly is, has been...

  8. Anomaly poles as common signatures of chiral and conformal anomalies

    International Nuclear Information System (INIS)

    One feature of the chiral anomaly, analyzed in a perturbative framework, is the appearance of massless poles which account for it. They are identified by a spectral analysis of the anomaly graph and are usually interpreted as being of an infrared origin. Recent investigations show that their presence is not just confined in the infrared, but that they appear in the effective action under the most general kinematical conditions, even if they decouple in the infrared. Further studies reveal that they are responsible for the non-unitary behaviour of these theories in the ultraviolet (UV) region. We extend this analysis to the case of the conformal anomaly, showing that the effective action describing the interaction of gauge fields with gravity is characterized by anomaly poles that give the entire anomaly and are decoupled in the infrared (IR), in complete analogy with the chiral case. This complements a related analysis by Giannotti and Mottola on the trace anomaly in gravity, in which an anomaly pole has been identified in the corresponding correlator using dispersion theory in the IR. Our extension is based on an exact computation of the off-shell correlation function involving an energy-momentum tensor and two vector currents (the gauge-gauge-graviton vertex) which is responsible for the appearance of the anomaly.

  9. Rare Upper Airway Anomalies.

    Science.gov (United States)

    Windsor, Alanna; Clemmens, Clarice; Jacobs, Ian N

    2016-01-01

    A broad spectrum of congenital upper airway anomalies can occur as a result of errors during embryologic development. In this review, we will describe the clinical presentation, diagnosis, and management strategies for a few select, rare congenital malformations of this system. The diagnostic tools used in workup of these disorders range from prenatal tests to radiological imaging, swallowing evaluations, indirect or direct laryngoscopy, and rigid bronchoscopy. While these congenital defects can occur in isolation, they are often associated with disorders of other organ systems or may present as part of a syndrome. Therefore workup and treatment planning for patients with these disorders often involves a team of multiple specialists, including paediatricians, otolaryngologists, pulmonologists, speech pathologists, gastroenterologists, and geneticists. PMID:26277452

  10. Trace anomaly driven inflation

    CERN Document Server

    Hawking, Stephen William; Reall, H S

    2001-01-01

    This paper investigates Starobinsky's model of inflation driven by the trace anomaly of conformally coupled matter fields. This model does not suffer from the problem of contrived initial conditions that occurs in inflation driven by a scalar field. The universe is nucleated semi-classically by a cosmological instanton that is much larger than the Planck scale provided there are sufficiently many matter fields. There are two cosmological instantons: the four sphere and a new ``double bubble'' solution. This paper considers a universe nucleated by the four sphere. The AdS/CFT correspondence is used to calculate the correlation function for scalar and tensor metric perturbations during the ensuing de Sitter phase. The analytic structure of the scalar and tensor propagators is discussed in detail. Observational constraints on the model are discussed. Quantum loops of matter fields are shown to strongly suppress short scale metric perturbations, which implies that short distance modifications of gravity would pro...

  11. Understanding diboson anomalies

    CERN Document Server

    Sajjad, Aqil

    2015-01-01

    We conduct a model-independent effective theory analysis of hypercharged fields with various spin structures towards understanding the recently observed diboson signal as well as possible future excesses involving $WZ$ and $WH$ modes. Within the assumption of no additional physics beyond the standard model up to the scale of the possible diboson resonance, we show that a hypercharged scalar and a spin 2 particle do not have tree-level $WZ$ and $WH$ decay channels up to dimension 5 operators, and cannot therefore account for the anomaly, whereas a hypercharged vector is a viable candidate provided we also introduce a $Z'$ in order to satisfy electroweak precision constraints. We calculate bounds on the $Z'$ mass consistent with the Atlas/CMS diboson signals as well as electroweak precision data.

  12. When lithium hurts: a look at Ebstein anomaly.

    Science.gov (United States)

    Osiro, Stephen; Tiwari, Kevin J; Mathenge, Njambi; Rodriguez, Jonier R; Tubbs, R Shane; Loukas, Marios

    2013-01-01

    Ebstein anomaly (EA) is a congenital defect of the tricuspid valve (TV) and the right ventricle (RV) in which the attachments of the septal and posterior valve leaflets are apically displaced. The latter creates 3 morphologic components inside the right heart, namely the right atrium proper, the atrialized RV, and the functional RV. This rare anomaly accounts for TV leaflets from the underlying myocardium and the interventricular septum. Its characteristic electrocardiographic findings include tall, broad, right atrial P waves, prolonged PR intervals, and deep Q waves in the right precordial leads. Echocardiography is currently the best technique for diagnosing this anomaly, although cardiac magnetic resonance imaging is also gaining traction as an alternative modality. The management strategies for EA correlate with the age of the patient, severity of the heart disease, and/or associated cardiac abnormalities. TV repair, rather than valve replacement, is preferred because of its favorable long-term prognosis. Nevertheless, a large, randomized study is still needed to compare the different valve repair techniques used in patients with EA. PMID:23269033

  13. CT assessment of tracheobronchial anomaly in left pulmonary artery sling

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, Yu-Min M.; Zhu, Ming; Sun, Ai-Min M.; Wang, Qian [Shanghai Jiao Tong University School of Medicine, Department of Radiology, Shanghai Children' s Medical Center, Shanghai (China); Jaffe, Richard B. [Primary Children' s Medical Center, Department of Medical Imaging, Salt Lake City, UT (United States); Gao, Wei [Shanghai Jiao Tong University School of Medicine, Department of Cardiology, Shanghai Children' s Medical Center, Shanghai (China)

    2010-11-15

    The left pulmonary artery sling (LPAS) is a rare vascular anomaly where the left pulmonary artery arises from the right pulmonary artery, passes over the right bronchus, and goes posteriorly between the trachea and esophagus. The LPAS is frequently associated with cardiac and non-cardiac defects including tracheobronchial abnormalities. To evaluate the utility of multislice CT (MSCT) and helical CT (HCT) in diagnosing and defining the tracheobronchial anomaly and anatomic relationships between the trachea and aberrant left pulmonary artery. MSCT or HCT was performed in 27 children to determine the tracheobronchial anatomy and identify tracheobronchial stenosis. Eighteen children underwent surgery. According to the Wells [6] classification of LPAS, which includes two main types and two subtypes, there were eight cases of type 1A, five cases of type 1B, six cases of type 2A and eight cases of type 2B in this group. Twenty-four of the 27 children had substantial tracheobronchial stenosis. Four died before surgery; the 18 had reanastomosis of the left pulmonary artery. Five children also had tracheoplasty; three died after surgery. CT, especially MSCT, is an ideal modality for simultaneously identifying aberrant left pulmonary artery and any associated tracheobronchial anomaly. The Wells classification is useful for operative planning. (orig.)

  14. Computed tomography of ano-rectal anomalies

    International Nuclear Information System (INIS)

    Computed tomography (CT) was performed in 9 patients with faecal incontinence more than 8 years after rectoplasty for high imperforate anus. The radiologic findings were correlated with the clinical evaluation of faecal incontinence. No statistically significant correlation was found between function and anatomic findings as demonstrated by CT. Thus, although CT demonstrates the post-operative anatomy in a detailed way, the information does not seem to be directly applicable when selecting the type of reoperation for faecal incontinence. (orig.)

  15. Seismic data fusion anomaly detection

    Science.gov (United States)

    Harrity, Kyle; Blasch, Erik; Alford, Mark; Ezekiel, Soundararajan; Ferris, David

    2014-06-01

    Detecting anomalies in non-stationary signals has valuable applications in many fields including medicine and meteorology. These include uses such as identifying possible heart conditions from an Electrocardiography (ECG) signals or predicting earthquakes via seismographic data. Over the many choices of anomaly detection algorithms, it is important to compare possible methods. In this paper, we examine and compare two approaches to anomaly detection and see how data fusion methods may improve performance. The first approach involves using an artificial neural network (ANN) to detect anomalies in a wavelet de-noised signal. The other method uses a perspective neural network (PNN) to analyze an arbitrary number of "perspectives" or transformations of the observed signal for anomalies. Possible perspectives may include wavelet de-noising, Fourier transform, peak-filtering, etc.. In order to evaluate these techniques via signal fusion metrics, we must apply signal preprocessing techniques such as de-noising methods to the original signal and then use a neural network to find anomalies in the generated signal. From this secondary result it is possible to use data fusion techniques that can be evaluated via existing data fusion metrics for single and multiple perspectives. The result will show which anomaly detection method, according to the metrics, is better suited overall for anomaly detection applications. The method used in this study could be applied to compare other signal processing algorithms.

  16. Axial anomaly in nonrenormalizable theories

    International Nuclear Information System (INIS)

    The anomaly for the axial current in nonrenormalizable theories with electromagnetic coupling is considered. The spinor electrodynamics with Pauli term is examined in detail using the Feynman graph technique and the point-splitting method. The same finite value for the axial anomaly emerges. (author)

  17. Algebraic study of chiral anomalies

    Indian Academy of Sciences (India)

    Juan Mañes; Raymond Stora; Bruno Zumino

    2012-06-01

    The algebraic structure of chiral anomalies is made globally valid on non-trivial bundles by the introduction of a fixed background connection. Some of the techniques used in the study of the anomaly are improved or generalized, including a systematic way of generating towers of ‘descent equations’.

  18. Anomaly mediation deformed by axion

    International Nuclear Information System (INIS)

    We show that in supersymmetric axion models the axion supermultiplet obtains a sizable F-term due to a non-supersymmetric dynamics and it generally gives the gaugino masses comparable to the anomaly mediation contribution. Thus the gaugino mass relation predicted by the anomaly mediation effect can be significantly modified in the presence of axion to solve the strong CP problem

  19. Trace Anomaly in Geometric Discretization

    OpenAIRE

    Czech, Bartlomiej

    2007-01-01

    I develop the simplest geometric-discretized analogue of two dimensional scalar field theory, which qualitatively reproduces the trace anomaly of the continuous theory. The discrete analogue provides an interpretation of the trace anomaly in terms of a non-trivial transformation of electric-magnetic duality-invariant modes of resistor networks that accommodate both electric and magnetic charge currents.

  20. Cardiac perception and cardiac control. A review.

    Science.gov (United States)

    Carroll, D

    1977-12-01

    The evidence regarding specific cardiac perception and discrimination, and its relationship to voluntary cardiac control, is critically reviewed. Studies are considered in three sections, depending on the method used to assess cardiac perception: questionnaire assessment, discrimination procedures, and heartbeat tracking. The heartbeat tracking procedure would appear to suffer least from interpretative difficulties. Recommendations are made regarding the style of analysis used to assess heartbeat perception in such tracking tasks. PMID:348240

  1. System for closure of a physical anomaly

    Energy Technology Data Exchange (ETDEWEB)

    Bearinger, Jane P; Maitland, Duncan J; Schumann, Daniel L; Wilson, Thomas S

    2014-11-11

    Systems for closure of a physical anomaly. Closure is accomplished by a closure body with an exterior surface. The exterior surface contacts the opening of the anomaly and closes the anomaly. The closure body has a primary shape for closing the anomaly and a secondary shape for being positioned in the physical anomaly. The closure body preferably comprises a shape memory polymer.

  2. Anomaly Poles as Common Signatures of Chiral and Conformal Anomalies

    CERN Document Server

    Armillis, Roberta; Rose, Luigi Delle

    2009-01-01

    One feature of the chiral anomaly, analyzed in a perturbative framework, is the appearance of massless poles which account for it. They are identified by a spectral analysis of the anomaly graph and are usually interpreted as being of an infrared origin. Recent investigations shown that their presence is not just confined in the infrared, but that they appear in the effective action under the most general kinematical conditions, even if they decouple in the infrared. Further studies reveal that they are responsible for the non-unitary behaviour of these theories in the ultraviolet (UV) region. We extend this analysis to the case of the conformal anomaly, showing that the effective action describing the interaction of gauge fields with gravity is characterized by anomaly poles that give the entire anomaly and are decoupled in the infrared (IR), in complete analogy with the chiral case. This complements a related analysis by Giannotti and Mottola on the trace anomaly in gravity, in which an anomaly pole has bee...

  3. Anesthetic considerations of an emergency decompressive craniotomy complicated with Ebstein's anomaly and atrial septal defect

    Institute of Scientific and Technical Information of China (English)

    XIN Xin; TANG Shuai; WANG Ling; ZHAO Jing; LI Gui-lin; GUO Li-lin; HUANG Yu-guang

    2011-01-01

    Despite considerable published papers regarding Ebstein's anomaly (EA) patients receiving open-heart tricuspid valve replacement, non-cardiac emergency surgeries were rarely reported. We report a case of emergency decormpressive craniotormy in a patient with EA. Anesthesiologists should pay special attention to the complications and anesthetic management during the non-cardiac surgeries performed in EA patients.hile papers regarding Ebstein's anomaly (EA)patients receiving open-heart tricuspid valve replacement are numerous, the reports of non-cardiac emergency surgeries have not been to the same degree.We report a case of emergency decompressive craniotomy in a patient with EA. This case report describes the symptoms and anesthetic management during the surgery.

  4. Evolutionary origin of cardiac malformations.

    Science.gov (United States)

    Taussig, H B

    1988-10-01

    The author has proposed in previous publications that isolated cardiac malformations have an evolutionary origin. This is partly supported by the fact that isolated cardiac malformations found in humans occur also in other placental mammals as well as in birds. External gross examination of the heart in just over 5,000 birds was carried out during a 3 year period. Anomalies included one instance of duplicate hearts, two specimens in which no heart could be identified and in a fourth, a yellow-rumped warbler, the heart lay in the neck outside of the thoracic cavity. Published reports of similar occurrences of an ectopically placed heart concern birds, cattle and humans. The fact that various species of both placental mammals and birds show evidence of heritability for heart defects, and that these species cannot interbreed, combined with the fact that birds and mammals have many similar malformations, points to either a common external causative factor or a common origin. Genes that code the malformed heart must be transmitted with that part of the genetic makeup common to all birds and mammals. Malformations caused by teratogens produce widespread organ injury to a potentially normal embryo whereas the evolutionary malformation is an organ-specific anomaly in an otherwise normal mammal or bird and occurs in widely separated species. The implications of this theory are important for parents of children with an isolated congenital heart defect who may have ingested one or another drug or chemical or have been exposed to toxins or infectious agents before or after conception of the affected offspring. PMID:3047192

  5. p16INK4A, p53, EGFR expression and KRAS mutation status in squamous cell cancers of the anus: Correlation with outcomes following chemo-radiotherapy

    International Nuclear Information System (INIS)

    Background and Purpose: Squamous cell carcinomas of the anal canal are associated with infection with Human Papilloma Viruses (HPVs). Chemo-radiotherapy (CRT) gives 70% 3-year relapse-free survival. Improved predictive markers and therapeutic options are required. Methods: Tumours from 153 patients treated with radical chemo-radiotherapy (50.4 Gy in 28 with concurrent Mitomycin and 5-Fluorouracil between 2004 and 2009) were retrieved and immunohistochemistry performed for p16INK4A, p53 and EGFR and correlated with outcome. Primary and relapsed samples were analysed for mutations in KRAS. Results: 137/153 (89.5%) stained moderately or strongly for p16INK4A. p16INK4A correlated strongly with outcome. 37/137 patients demonstrating moderate/strong p16INK4A expression relapsed (27.0%), as opposed to 10/16 (62.5%) with absent/weak staining (log rank test p INK4A negative tumours were more frequent in men. p16INK4A negative patients had significantly worse overall survival (p INK4A is strongly associated with relapse in SCC of the anus and identifies patients with very poor rates of relapse-free and overall survival. Primary and recurrent anal cancer expresses wild type KRAS, unaffected by treatment, supporting trials targeting EGFR in poor risk/recurrent anal cancer

  6. What Is Cardiac Rehabilitation?

    Science.gov (United States)

    ANSWERS by heart Treatments + Tests What Is Cardiac Rehabilitation? A cardiac rehabilitation (rehab) program takes place in a hospital or ... special help in making lifestyle changes. During your rehabilitation program you’ll… • Have a medical evaluation to ...

  7. Binning of satellite magnetic anomalies

    Science.gov (United States)

    Goyal, H. K.; Vonfrese, R. R. B.; Hinze, W. J.

    1985-01-01

    Crustal magnetic anomaly signals over satellite orbits were simulated to investigate numerical averaging as an anomaly estimator. Averaging as an anomaly estimator involves significant problems concerning spatial and amplitude smoothing of the satellite magnetic observations. The results of simulations suggest that the error of numerical averaging constitutes a small and relatively minor component of the total error-budget of higher orbital anomaly estimates, whereas for lower orbital estimates numerical averaging error increases substantially. As an alternative to numerical averaging, least-squares collocation was investigated and observed to produce substantially more accurate anomaly estimates, particularly as the orbital elevation of prediction was decreased towards the crustal sources. In contrast to averaging, collocation is a significantly more resource-intensive procedure to apply because of the practical, but surmountable problems related to establishing and inverting the covariance matrix for accurate anomaly prediction. However, collocation may be much more effectively used to exploit the anomaly details contained in the lower orbital satellite magnetic data for geologic analysis.

  8. BRS cohomology and topological anomalies

    International Nuclear Information System (INIS)

    The occurrence of non-abelian anomalies in gauge theories and gravitation, first discovered via perturbative techniques, is now completely explained from the mathematical point of view by means of the family index theorem of Atiyah and Singer. Here we make contact between this approach and BRS cohomology, by showing that they yield the same non-abelian anomalies, provided a certain restriction to ''local'' functionals is not introduced from the very beginning. In particular, this solves the ''unicity'' problem for this kind of anomalies. Local BRS cohomology is still relevant for the abelian case. (orig.)

  9. Clinical Analysis of 19 young children with congenital imperforated anus operated with Perine-um-anoplasty%会阴肛门成形术治疗先天性无肛19例临床分析

    Institute of Scientific and Technical Information of China (English)

    黄德铨; 侯艳梅; 许璟; 康健; 琚晓; 廖波; 袁可

    2011-01-01

    目的 分析和评估会阴肛门成形术治疗先天性中低位无肛患儿的疗效.方法 回顾性分析2003年10月至2010年8月我科收治的19例中低位无肛畸形儿采用会阴肛门成形术治疗的临床资料.结果 术后随访3个月至3年,19例患儿肛门功能及排便功能正常.结论 会阴肛门成形术治疗中低位无肛疗效是确切的,值得临床推广.%Objective To analyze and evaluate the efficacy of treating intermediate and low congenital imperforated anus with Perineum-anoplasty. Methods From Oct. 2003 to Aug. 2010, 19 young children with intermediate and low congenital imperforated anus were operated with Perineum-anoplasty. Results The cases had been followed up for 3 to 36 months. Anal function and defecation were normal with satisfactory.Conclusion The efficacy of treating congenital intermediate and low congenital imperforated anus with Perineum-anoplasty is accurate, and it is worth promoting in the clinic.

  10. Diffuse infiltrative cardiac tuberculosis

    International Nuclear Information System (INIS)

    We present the cardiac magnetic resonance images of an unusual form of cardiac tuberculosis. Nodular masses in a sheet-like distribution were seen to infiltrate the outer myocardium and pericardium along most of the cardiac chambers. The lesions showed significant resolution on antitubercular therapy

  11. Ebstein's anomaly with imperforate tricuspid valve. Prenatal diagnosis

    Directory of Open Access Journals (Sweden)

    Zielinsky Paulo

    2000-01-01

    Full Text Available Ebstein's anomaly is an uncommon congenital heart defect, with a prevalence of 0.3-0.5%. Its association with an imperforate tricuspid valve is an even more rare situation (less than 10% of cases. Prenatal diagnosis of this association by means of fetal echocardiography has not been reported. We describe here this association diagnosed before birth and confirmed after birth. The diagnostic potential and importance of fetal echocardiography during prenatal evaluation of cardiac malformations allows for adequate perinatal planning and management, with an obvious impact on morbidity and mortality.

  12. Interior Alaska Bouguer Gravity Anomaly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A 1 kilometer Complete Bouguer Anomaly gravity grid of interior Alaska. Only those grid cells within 10 kilometers of a gravity data point have gravity values....

  13. Interior Alaska Bouguer Gravity Anomaly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A 1 kilometer Complete Bouguer Anomaly gravity grid of interior Alaska. All grid cells within the rectangular data area (from 61 to 66 degrees North latitude and...

  14. On renormalization of axial anomaly

    International Nuclear Information System (INIS)

    It is shown that multiplicative renormalization of the axial singlet current results in renormalization of the axial anomaly in all orders of perturbation theory. It is a necessary condition for the Adler - Bardeen theorem being valid. 10 refs.; 2 figs

  15. Prevalence of Congenital Coronary Artery Anomalies and Variants in 2697 Consecutive Patients Using 64-Detector Row Coronary CTAngiography

    OpenAIRE

    Farzaneh Fattahi Masrour; Reza Tayebivaljozi,; Shahram Akhlaghpoor; Abbas Arjmand Shabestari

    2012-01-01

    Background: Coronary artery anomalies are not common, but could be very serious.Objectives: This study determines the frequency of coronary anomalies and normal variants by multi-detector-row computed tomography (MDCT).Patients and Methods: The results of cardiac MDCT study in 2697 consecutive patients were analyzed retrospectively. Acquisition was performed by a 64-detector row CT machine. Imaging results were assessed by experienced radiologists.Results: Myocardial bridging was by far the m...

  16. Prevalence of Congenital Coronary Artery Anomalies and Variants in 2697 Consecutive Patients Using 64-Detector Row Coronary CTAngiography

    OpenAIRE

    Shabestari, Abbas Arjmand; Akhlaghpoor, Shahram; Tayebivaljozi, Reza; Fattahi Masrour, Farzaneh

    2012-01-01

    Background Coronary artery anomalies are not common, but could be very serious. Objectives This study determines the frequency of coronary anomalies and normal variants by multi-detector-row computed tomography (MDCT). Patients and Methods The results of cardiac MDCT study in 2697 consecutive patients were analyzed retrospectively. Acquisition was performed by a 64-detector row CT machine. Imaging results were assessed by experienced radiologists. Results Myocardial bridging was by far the mo...

  17. Second order transport from anomalies

    OpenAIRE

    Sayantani Bhattacharyya; David, Justin R.; Somyadip Thakur

    2013-01-01

    We study parity odd transport at second order in derivative expansion for a non-conformal charged fluid. We see that there are 27 parity odd transport coefficients, of which 12 are non-vanishing in equilibrium. We use the equilibrium partition function method to express 7 of these in terms of the anomaly, shear viscosity, charge diffusivity and thermodynamic functions. The remaining 5 are constrained by 3 relations which also involve the anomaly. We derive Kubo formulae for 2 of the transport...

  18. Boundary Anomalies and Correlation Functions

    OpenAIRE

    Huang, Kuo-Wei(C.N. Yang Institute for Theoretical Physics, Department of Physics and Astronomy, Stony Brook University, Stony Brook, NY, 11794, U.S.A.)

    2016-01-01

    It was shown recently that boundary terms of conformal anomalies recover the universal contribution to the entanglement entropy and also play an important role in the boundary monotonicity theorem of odd-dimensional quantum field theories. Motivated by these results, we investigate relationships between boundary anomalies and the stress tensor correlation functions in conformal field theories. In particular, we focus on how the conformal Ward identity and the renormalization group equation ar...

  19. Situs anomalies on prenatal MRI

    International Nuclear Information System (INIS)

    Objective: Situs anomalies refer to an abnormal organ arrangement, which may be associated with severe errors of development. Due regard being given to prenatal magnetic resonance imaging (MRI) as an adjunct to ultrasonography (US), this study sought to demonstrate the in utero visualization of situs anomalies on MRI, compared to US. Materials and methods: This retrospective study included 12 fetuses with situs anomalies depicted on fetal MRI using prenatal US as a comparison modality. With an MRI standard protocol, the whole fetus was assessed for anomalies, with regard to the position and morphology of the following structures: heart; venous drainage and aorta; stomach and intestines; liver and gallbladder; and the presence and number of spleens. Results: Situs inversus totalis was found in 3/12 fetuses; situs inversus with levocardia in 1/12 fetuses; situs inversus abdominis in 2/12 fetuses; situs ambiguous with polysplenia in 3/12 fetuses, and with asplenia in 2/12 fetuses; and isolated dextrocardia in 1/12 fetuses. Congenital heart defects (CHDs), vascular anomalies, and intestinal malrotations were the most frequent associated malformations. In 5/12 cases, the US and MRI diagnoses were concordant. Compared to US, in 7/12 cases, additional MRI findings specified the situs anomaly, but CHDs were only partially visualized in six cases. Conclusions: Our initial MRI results demonstrate the visualization of situs anomalies and associated malformations in utero, which may provide important information for perinatal management. Using a standard protocol, MRI may identify additional findings, compared to US, which confirm and specify the situs anomaly, but, with limited MRI visualization of fetal CHDs.

  20. Gravitational anomaly and transport phenomena

    OpenAIRE

    Landsteiner, Karl; Megías Fernández, Eugenio; Pena-Benítez, Francisco

    2011-01-01

    Quantum anomalies give rise to new transport phenomena. In particular, a magnetic field can induce an anomalous current via the chiral magnetic effect and a vortex in the relativistic fluid can also induce a current via the chiral vortical effect. The related transport coefficients can be calculated via Kubo formulas. We evaluate the Kubo formula for the anomalous vortical conductivity at weak coupling and show that it receives contributions proportional to the gravitational anomaly coefficie...

  1. Satellite elevation magnetic anomaly maps

    Science.gov (United States)

    Braile, L. W.; Hinze, W. J. (Principal Investigator)

    1982-01-01

    The problem of inverting 2 deg average MAGSAT scalar anomalies for the region 80 W, 60 E longitude and 40 S, 70 N latitude was attempted on the LARS computer; however, the effort was aborted due to insufficient allocation of CPU-time. This problem is currently being resubmitted and should be implemented shortly for quantitative comparison with free-air gravity anomaly, geothermal, and tectonic data.

  2. Space weather and space anomalies

    Directory of Open Access Journals (Sweden)

    L. I. Dorman

    2005-11-01

    Full Text Available A large database of anomalies, registered by 220 satellites in different orbits over the period 1971-1994 has been compiled. For the first time, data from 49 Russian Kosmos satellites have been included in a statistical analysis. The database also contains a large set of daily and hourly space weather parameters. A series of statistical analyses made it possible to quantify, for different satellite orbits, space weather conditions on the days characterized by anomaly occurrences. In particular, very intense fluxes (>1000 pfu at energy >10 MeV of solar protons are linked to anomalies registered by satellites in high-altitude (>15000 km, near-polar (inclination >55° orbits typical for navigation satellites, such as those used in the GPS network, NAVSTAR, etc. (the rate of anomalies increases by a factor ~20, and to a much smaller extent to anomalies in geostationary orbits, (they increase by a factor ~4. Direct and indirect connections between anomaly occurrence and geomagnetic perturbations are also discussed.

  3. Aeromagnetic anomalies over faulted strata

    Science.gov (United States)

    Grauch, V.J.S.; Hudson, Mark R.

    2011-01-01

    High-resolution aeromagnetic surveys are now an industry standard and they commonly detect anomalies that are attributed to faults within sedimentary basins. However, detailed studies identifying geologic sources of magnetic anomalies in sedimentary environments are rare in the literature. Opportunities to study these sources have come from well-exposed sedimentary basins of the Rio Grande rift in New Mexico and Colorado. High-resolution aeromagnetic data from these areas reveal numerous, curvilinear, low-amplitude (2–15 nT at 100-m terrain clearance) anomalies that consistently correspond to intrasedimentary normal faults (Figure 1). Detailed geophysical and rock-property studies provide evidence for the magnetic sources at several exposures of these faults in the central Rio Grande rift (summarized in Grauch and Hudson, 2007, and Hudson et al., 2008). A key result is that the aeromagnetic anomalies arise from the juxtaposition of magnetically differing strata at the faults as opposed to chemical processes acting at the fault zone. The studies also provide (1) guidelines for understanding and estimating the geophysical parameters controlling aeromagnetic anomalies at faulted strata (Grauch and Hudson), and (2) observations on key geologic factors that are favorable for developing similar sedimentary sources of aeromagnetic anomalies elsewhere (Hudson et al.).

  4. Neurodevelopmental Outcomes After Cardiac Surgery in Infancy

    Science.gov (United States)

    Stopp, Christian; Wypij, David; Andropoulos, Dean B.; Atallah, Joseph; Atz, Andrew M.; Beca, John; Donofrio, Mary T.; Duncan, Kim; Ghanayem, Nancy S.; Goldberg, Caren S.; Hövels-Gürich, Hedwig; Ichida, Fukiko; Jacobs, Jeffrey P.; Justo, Robert; Latal, Beatrice; Li, Jennifer S.; Mahle, William T.; McQuillen, Patrick S.; Menon, Shaji C.; Pemberton, Victoria L.; Pike, Nancy A.; Pizarro, Christian; Shekerdemian, Lara S.; Synnes, Anne; Williams, Ismee; Bellinger, David C.; Newburger, Jane W.

    2015-01-01

    BACKGROUND: Neurodevelopmental disability is the most common complication for survivors of surgery for congenital heart disease (CHD). METHODS: We analyzed individual participant data from studies of children evaluated with the Bayley Scales of Infant Development, second edition, after cardiac surgery between 1996 and 2009. The primary outcome was Psychomotor Development Index (PDI), and the secondary outcome was Mental Development Index (MDI). RESULTS: Among 1770 subjects from 22 institutions, assessed at age 14.5 ± 3.7 months, PDIs and MDIs (77.6 ± 18.8 and 88.2 ± 16.7, respectively) were lower than normative means (each P < .001). Later calendar year of birth was associated with an increased proportion of high-risk infants (complexity of CHD and prevalence of genetic/extracardiac anomalies). After adjustment for center and type of CHD, later year of birth was not significantly associated with better PDI or MDI. Risk factors for lower PDI were lower birth weight, white race, and presence of a genetic/extracardiac anomaly (all P ≤ .01). After adjustment for these factors, PDIs improved over time (0.39 points/year, 95% confidence interval 0.01 to 0.78; P = .045). Risk factors for lower MDI were lower birth weight, male gender, less maternal education, and presence of a genetic/extracardiac anomaly (all P < .001). After adjustment for these factors, MDIs improved over time (0.38 points/year, 95% confidence interval 0.05 to 0.71; P = .02). CONCLUSIONS: Early neurodevelopmental outcomes for survivors of cardiac surgery in infancy have improved modestly over time, but only after adjustment for innate patient risk factors. As more high-risk CHD infants undergo cardiac surgery and survive, a growing population will require significant societal resources. PMID:25917996

  5. Cardiac tumours in children

    Directory of Open Access Journals (Sweden)

    Parsons Jonathan M

    2007-03-01

    Full Text Available Abstract Cardiac tumours are benign or malignant neoplasms arising primarily in the inner lining, muscle layer, or the surrounding pericardium of the heart. They can be primary or metastatic. Primary cardiac tumours are rare in paediatric practice with a prevalence of 0.0017 to 0.28 in autopsy series. In contrast, the incidence of cardiac tumours during foetal life has been reported to be approximately 0.14%. The vast majority of primary cardiac tumours in children are benign, whilst approximately 10% are malignant. Secondary malignant tumours are 10–20 times more prevalent than primary malignant tumours. Rhabdomyoma is the most common cardiac tumour during foetal life and childhood. It accounts for more than 60% of all primary cardiac tumours. The frequency and type of cardiac tumours in adults differ from those in children with 75% being benign and 25% being malignant. Myxomas are the most common primary tumours in adults constituting 40% of benign tumours. Sarcomas make up 75% of malignant cardiac masses. Echocardiography, Computing Tomography (CT and Magnetic Resonance Imaging (MRI of the heart are the main non-invasive diagnostic tools. Cardiac catheterisation is seldom necessary. Tumour biopsy with histological assessment remains the gold standard for confirmation of the diagnosis. Surgical resection of primary cardiac tumours should be considered to relieve symptoms and mechanical obstruction to blood flow. The outcome of surgical resection in symptomatic, non-myxomatous benign cardiac tumours is favourable. Patients with primary cardiac malignancies may benefit from palliative surgery but this approach should not be recommended for patients with metastatic cardiac tumours. Surgery, chemotherapy and radiotherapy may prolong survival. The prognosis for malignant primary cardiac tumours is generally extremely poor.

  6. A case report of congenitally corrected transposition of great arteries: Morphologic and functional evaluation with cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Heon; Park, Byoung Won [College of Medicine, Soonchunhyang University, Bucheon Hospital, Bucheon (Korea, Republic of)

    2013-09-15

    Congenitally corrected transposition of the great arteries (ccTGA) is a rare congenital anomaly characterized by atrioventricular and ventriculoarterial discordance. We report a case of new-onset heart failure in a 69-year-old female in whom cardiac CT demonstrated ccTGA without the associated cardiovascular anomalies. In this case, cardiac CT was useful for elucidating the rare and unexpected congenital etiologies of abrupt-onset heart failure in an old patient by the simultaneous evaluation of cardiac morphology and function as a single study (inserted).

  7. Prenatal sonographic diagnosis of focal musculoskeletal anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jung Kyu; Cho, Jeong Yeon; Lee, Young Ho; Kim, Ei Jeong; Chun, Yi Kyeong [Samsung Cheil Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2002-09-15

    Focal musculoskeletal anomalies are various and may be an isolated finding or may be found in conjunction with numerous associations, including genetic syndromes, Karyotype abnormals, central nervous system anomalies and other general musculoskeletal disorders. Early prenatal diagnosis of these focal musculoskeletal anomalies nor only affects prenatal care and postnatal outcome but also helps in approaching other numerous associated anomalies.

  8. Stimulating endogenous cardiac regeneration

    Directory of Open Access Journals (Sweden)

    Amanda eFinan

    2015-09-01

    Full Text Available The healthy adult heart has a low turnover of cardiac myocytes. The renewal capacity, however, is augmented after cardiac injury. Participants in cardiac regeneration include cardiac myocytes themselves, cardiac progenitor cells, and peripheral stem cells, particularly from the bone marrow compartment. Cardiac progenitor cells and bone marrow stem cells are augmented after cardiac injury, migrate to the myocardium, and support regeneration. Depletion studies of these populations have demonstrated their necessary role in cardiac repair. However, the potential of these cells to completely regenerate the heart is limited. Efforts are now being focused on ways to augment these natural pathways to improve cardiac healing, primarily after ischemic injury but in other cardiac pathologies as well. Cell and gene therapy or pharmacological interventions are proposed mechanisms. Cell therapy has demonstrated modest results and has passed into clinical trials. However, the beneficial effects of cell therapy have primarily been their ability to produce paracrine effects on the cardiac tissue and recruit endogenous stem cell populations as opposed to direct cardiac regeneration. Gene therapy efforts have focused on prolonging or reactivating natural signaling pathways. Positive results have been demonstrated to activate the endogenous stem cell populations and are currently being tested in clinical trials. A potential new avenue may be to refine pharmacological treatments that are currently in place in the clinic. Evidence is mounting that drugs such as statins or beta blockers may alter endogenous stem cell activity. Understanding the effects of these drugs on stem cell repair while keeping in mind their primary function may strike a balance in myocardial healing. To maximize endogenous cardiac regeneration,a combination of these approaches couldameliorate the overall repair process to incorporate the participation ofmultiple cell players.

  9. Canine fetal echocardiography: correlations for the analysis of cardiac dimensions.

    Science.gov (United States)

    Giannico, Amália Turner; Gil, Elaine Mayumi Ueno; Garcia, Daniela Aparecida Ayres; Sousa, Marlos Gonçalves; Froes, Tilde Rodrigues

    2016-03-01

    The aim of this study was to develop regression models for correlation of canine fetal heart development with body size to characterize normal development or suggest cardiac anomalies. Twenty clinically healthy pregnant bitches, either brachycephalic and non-brachycephalic, were examined ultrasonographically. Transabdominal fetal echocardiography was conducted every 4 days from the beginning of cardiac chambers differentiation until parturition. Ten cardiac parameters were measured: length, width and diameter of the heart; heart area; left and right ventricular dimensions; left and right atrial dimensions; and aortic and pulmonary artery diameter. Femoral length, biparietal diameter and abdominal cross-sectional area were also recorded. Regression equations were developed for each parameter of fetal body size, and linear and logarithmic models were compared. The model with the highest correlation coefficient was chosen to produce equations to calculate relative dimensions based on the correlations. Only the left-ventricular chamber differed between the two racial groups. Biparietal diameter was the independent parameter that produced the highest correlation coefficient for the most fetal cardiac dimensions, although good correlations were also observed using femoral length and abdominal cross-sectional area. Heart width and heart diameter were used as surrogates of cardiac development, as these measurements showed the best statistical correlation. Quantitative evaluation of fetal cardiac structures can be used to monitor normal and abnormal cardiac development. PMID:26689920

  10. Prenatal Sonographic Diagnosis of Focal Musculoskeletal Anomalies

    OpenAIRE

    Ryu, Jung Kyu; Cho, Jeong Yeon; Choi, Jong Sun

    2003-01-01

    Focal musculoskeletal anomalies vary, and can manifest as part of a syndrome or be accompanied by numerous other conditions such as genetic disorders, karyotype abnormalities, central nervous system anomalies and other skeletal anomalies. Isolated focal musculoskeletal anomaly does, however, also occur; its early prenatal diagnosis is important in deciding prenatal care, and also helps in counseling parents about the postnatal effects of numerous possible associated anomalies. We have encount...

  11. GEOMAGNETIC ANOMALY FIELD VECTOR OFF WESTERN AUSTRALIA

    OpenAIRE

    ノギ, ヨシフミ; エグチ, ヨシアキ; セアマ, ノブカズ; イセザキ, ノブヒロ; Yoshifumi, NOGI; Yoshiaki, EGUCHI; Nobukazu, SEAMA; Nobuhiro, ISEZAKI

    1993-01-01

    Vector data of the geomagnetic anomaly field were obtained during the 32nd Japanese Antarctic Research Expedition (JARE-32) off Western Australia. The strikes of the magnetic boundaries at their position were derived from vector data of the geomagnetic anomaly field. These strikes were interpreted as the directions of magnetic anomaly lineations originated either by seafloor spreading (seafloor spreading anomaly) or by morphological structures (structural magnetic anomaly). Some strikes of st...

  12. PSEUDO MAGNETIC ANOMALIES IN THE ANTARCTIC SEA

    OpenAIRE

    マツモト, タケシ; カミヌマ, カツタダ; Takeshi, MATSUMOTO; Katsutada, Kaminuma

    1988-01-01

    Pseudo magnetic anomaly in the Antarctic Sea has been calculated using the gravity data derived from altimetric geoid. Comparison of the pseudo magnetic anomaly thus calculated with the theoretical magnetic anomaly predicted from topography has been made with respect to the large fracture zones composed of short-wavelength ridges and troughs in the Southeastern Pacific, which shows that these two anomalies coincide well with each other. Gravity anomaly calculated from topography only also coi...

  13. Global gravitational anomalies and transport

    CERN Document Server

    Chowdhury, Subham Dutta

    2016-01-01

    We investigate the constraints imposed by global gravitational anomalies on parity odd induced transport coefficients in even dimensions for theories with chiral fermions, gravitinos and self dual tensors. The $\\eta$-invariant for the large diffeomorphism corresponding to the $T$ transformation on a torus constraints the coefficients in the thermal effective action up to mod 2. We show that the result obtained for the parity odd transport for gravitinos using global anomaly matching is consistent with the direct perturbative calculation. In $d=6$ we see that the second Pontryagin class in the anomaly polynomial does not contribute to the $\\eta$-invariant which provides a topological explanation of this observation in the `replacement rule'. We then perform a direct perturbative calculation for the contribution of the self dual tensor in $d=6$ to the parity odd transport coefficient using the Feynman rules proposed by Gaum\\'{e} and Witten. The result for the transport coefficient agrees with that obtained usin...

  14. Graph anomalies in cyber communications

    Energy Technology Data Exchange (ETDEWEB)

    Vander Wiel, Scott A [Los Alamos National Laboratory; Storlie, Curtis B [Los Alamos National Laboratory; Sandine, Gary [Los Alamos National Laboratory; Hagberg, Aric A [Los Alamos National Laboratory; Fisk, Michael [Los Alamos National Laboratory

    2011-01-11

    Enterprises monitor cyber traffic for viruses, intruders and stolen information. Detection methods look for known signatures of malicious traffic or search for anomalies with respect to a nominal reference model. Traditional anomaly detection focuses on aggregate traffic at central nodes or on user-level monitoring. More recently, however, traffic is being viewed more holistically as a dynamic communication graph. Attention to the graph nature of the traffic has expanded the types of anomalies that are being sought. We give an overview of several cyber data streams collected at Los Alamos National Laboratory and discuss current work in modeling the graph dynamics of traffic over the network. We consider global properties and local properties within the communication graph. A method for monitoring relative entropy on multiple correlated properties is discussed in detail.

  15. Preoperative cardiac risk management

    OpenAIRE

    Vidaković Radosav; Poldermans Don; Nešković Aleksandar N.

    2011-01-01

    Approximately 100 million people undergo noncardiac surgery annually worldwide. It is estimated that around 3% of patients undergoing noncardiac surgery experience a major adverse cardiac event. Although cardiac events, like myocardial infarction, are major cause of perioperative morbidity or mortality, its true incidence is difficult to assess. The risk of perioperative cardiac complications depends mainly on two conditions: 1) identified risk factors, and 2) the type of the surgical p...

  16. A single coronary artery with the right coronary artery originating from the left anterior descending artery detected by cardiac CT: A case report

    International Nuclear Information System (INIS)

    The right coronary artery arising from the left anterior descending artery is a rare coronary artery anomaly. In a 56 year old female, an anomaly with the right coronary artery, originating from the left anterior descending artery, coursing anteriorly to the pulmonary artery was detected by cardiac CT. Therefore, we hereby report a case of the single left coronary artery diagnosed by a 64 slice multidetector cardiac CT

  17. Boundary Anomalies and Correlation Functions

    CERN Document Server

    Huang, Kuo-Wei

    2016-01-01

    It was shown recently that boundary terms of conformal anomalies recover the universal contribution to the entanglement entropy and also play an important role in the boundary monotonicity theorem of odd-dimensional quantum field theories. Motivated by these results, we investigate relationships between boundary anomalies and the stress tensor correlation functions in conformal field theories. In particular, we focus on how the conformal Ward identity and the renormalization group equation are modified by boundary central charges. Renormalized stress tensors induced by boundary Weyl invariants are also discussed, with examples in spherical and cylindrical geometries.

  18. Holomorphic anomaly and matrix models

    CERN Document Server

    Eynard, B; Orantin, Nicolas; Eynard, Bertrand; Marino, Marcos; Orantin, Nicolas

    2007-01-01

    The genus g free energies of matrix models can be promoted to modular invariant, non-holomorphic amplitudes which only depend on the geometry of the classical spectral curve. We show that these non-holomorphic amplitudes satisfy the holomorphic anomaly equations of Bershadsky, Cecotti, Ooguri and Vafa. We derive as well holomorphic anomaly equations for the open string sector. These results provide evidence at all genera for the Dijkgraaf--Vafa conjecture relating matrix models to type B topological strings on certain local Calabi--Yau threefolds.

  19. Detection of malignant right coronary artery anomaly by multi-slice CT coronary angiography

    International Nuclear Information System (INIS)

    Coronary artery anomalies occur in 0.3-0.8% of the population and infer a high risk for sudden cardiac death in young adults. Diagnosis is usually established during coronary angiography, which is hampered by poor spatial visualization. Magnetic resonance imaging is an alternative, but it is not feasible in the presence of metal objects or claustrophobia. In this report, a 15-year-old boy experienced ventricular fibrillation and was successfully resuscitated. Cardiac catheterization was inconclusive, and pacemaker implantation prohibited the use of MR imaging. Multi-slice CT coronary angiography revealed a malignant anomalous right coronary artery. (orig.)

  20. Concomitant slide tracheoplasty and cardiac operation for congenital tracheal stenosis associated with VACTERL.

    Science.gov (United States)

    Wu, En-Ting; Wang, Ching-Chia; Lin, Ming-Tai; Huang, Pei-Ming; Chen, Shyh-Jye; Huang, Chi-Hsiang; Hwang, Haw-Kwei; Chen, Ming-Ren; Huang, Shu-Chien

    2013-10-01

    The association of congenital tracheal stenosis and tracheoesophageal (TE) fistula is rare. Here, we report 2 patients with tracheobronchial stenosis (complete cartilage ring) involving the lower trachea and right bronchus. Both patients had associated VACTERL (vertebral anomalies, anal atresia, cardiovascular anomalies, TE, renal, and limb defects) congenital cardiac defects and tracheal diverticula after repair of the TE fistula in type C esophageal atresia. The stenotic segment began at the orifice of the TE fistula, which became diverticula after the TE fistula was repaired. Concomitant repair of congenital cardiac defects and a slide tracheoplasty with elimination of the diverticula were performed successfully. PMID:24088476

  1. Dyshormonogenetic goiter and associated non-thyroidal anomalies

    Directory of Open Access Journals (Sweden)

    Khalid J Farooqui

    2012-01-01

    Full Text Available Background: Dyshormonogenetic goiter (DG refers to familial goitres owing to an inherited defect in the metabolism of thyroid hormones and accounts for 10-15% of all cases of congenital hypothyroidism. Aim and Objective: To identify dysmorphic features, cardiac and urogenital anomalies in patients with DG following in the pediatric endocrinology clinic. Materials and Methods: Eight adolescents following the pediatric endocrinology clinic for hypothyroidism and associated stigmata were identified with dyshormonogenesis using 99mTc radionuclide thyroid scintigraphy and confirmation by the Perchlorate discharge test during a 6-month period from January to July 2012. Screening for associated malformations was done using clinical examination, echocardiography and ultrasonography of abdomen. Results: The eight patients (two boys and six girls had a mean age of 9.87 years. The mean duration of goitre was 36.12 months. Two patients had mental retardation and delayed developmental milestones one of whom had ectopic left kidney on renal scintigraphy. Mitral regurgitation was seen in one patient whereas renal anomalies in the form of ectopic kidney and small/contracted kidney with grade III hydronephrosis was seen in two patients. Penoscrotal hypospadias was identified in one of the patients who also had small/contracted kidney with grade III hydronephrosis and underwent pyeloplasty for the same. Dysmorphic features in the form of high arched palate, depressed nasal bridge and low set ears was seen in one patient. Conclusion: DG is associated with other extra-thyroidal congenital anomaly, some of which may need to be treated.

  2. Colon,rectum and anus

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    950328 Stepwise regression analysis on affective fac-tor of the changes in gastrin and somatostatin in col-orectal cancer patients.WANG Yuanhe(王元和),etal.2nd Milit Med Univ,Shanghai,200003.Med J ChinPLA 1995:20(1):48-51.Gastrin and somatostatin (SS) levels in peripheralblood,tumor and its surrounding mucosa were deter-mined in 40 colorectal cancer patients by RIA with theserum gastrin (SG),plasma SS(PS),tumor SS(TS)or cancer-adjacent mucosa (CAMS)SS(CAMS)lev-els were taken as dependent variables and the remain-ing variables(including gastrin and SS levels,age and

  3. Colon,rectum and anus

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    930135 Induction of expression of HLA anti-gens,carcinoembryonic antigen and oncogeneproduct on human colorectal cancer cell lineswith interferon-γ.WANG Ling(王聆),et al.Immunol Instit,Shanghai 2nd Med Univ.Chin J

  4. Capacity building model for increased access to quality cardiac care for children in underserved regions

    OpenAIRE

    Bistra Zheleva, MBA; Andreas Tsakistos, MA; Erin Murley, BA; Emily Dale, MPH CHES

    2014-01-01

    Background: Congenital heart anomalies are the most common major birth defect in the world, affecting one in every 120 children, 90% of whom live where medical care is inadequate or unavailable. Increased access to paediatric cardiac care is a priority for most low-income and middle-income countries today. Children's HeartLink is dedicated to increasing access and improving quality at paediatric cardiac centres by use of a collaborative model that fosters sustainable clinical, organisational,...

  5. Conotruncal anomalies in the fetus: Referral patterns and pregnancy outcomes in a dedicated fetal cardiology unit in South India

    Directory of Open Access Journals (Sweden)

    Balu Vaidyanathan

    2013-01-01

    Conclusions: Pre-natal diagnosis of CTA, despite a high diagnostic accuracy, prompted utilization of post-natal tertiary cardiac care in a limited proportion of patients, including those with reparable lesions. Focus in developing countries should shift towards earlier referral, improving awareness about treatment options and a comprehensive evaluation for associated anomalies.

  6. Gaugino-Assisted Anomaly Mediation

    International Nuclear Information System (INIS)

    We present a model of supersymmetry breaking mediated through a small extra dimension. Standard model matter multiplets and a supersymmetry-breaking (or ''hidden'') sector are confined to opposite four-dimensional boundaries while gauge multiplets live in the bulk. The hidden sector does not contain a singlet and the dominant contribution to gaugino masses is via anomaly-mediated supersymmetry breaking. Scalar masses get contributions from both anomaly mediation and a tiny hard breaking of supersymmetry by operators on the hidden-sector boundary. These operators contribute to scalar masses at one loop and in most of parameter space, their contribution dominates. Thus it is easy to make all squared scalar masses positive. As no additional fields or symmetries are required below the Planck scale, we consider this the simplest working model of anomaly mediation. The gaugino spectrum is left untouched and the phenomenology of the model is roughly similar to anomaly mediated supersymmetry breaking with a universal scalar mass added. We identify the main differences in the spectrum between this model and other approaches. We also discuss mechanisms for generating the μ term and constraints on additional bulk fields. (author)

  7. Gaugino-assisted anomaly mediation

    International Nuclear Information System (INIS)

    I present a model of supersymmetry breaking mediated through a small extra dimension. Standard model matter multiplets and a supersymmetry-breaking (or 'hidden') sector are confined to opposite four-dimensional boundaries while gauge multiplets live in the bulk. The hidden sector does not contain a singlet and the dominant contribution to gaugino masses is via anomaly-mediated supersymmetry breaking. Scalar masses get contributions from both anomaly mediation and a tiny hard breaking of supersymmetry by operators on the hidden-sector boundary. These operators contribute to scalar masses at one loop and in most of parameter space, their contribution dominates. Thus it is easy to make all squared scalar masses positive. As no additional fields or symmetries are required below the Planck scale, this is among the simplest working models of anomaly mediation. The gaugino spectrum is left untouched and the phenomenology of the model is roughly similar to anomaly mediated supersymmetry breaking with a universal scalar mass added. Finally, the main differences in the spectrum between this model and other approaches are identified. This talk is based on work [1] done in collaboration with David E. Kaplan

  8. Intervention Effects of Guangtongxiao (广痛消)Foam Aerosol on Anus Edema Model in Rats%广痛消泡沫气雾剂对大鼠肛门水肿的作用

    Institute of Scientific and Technical Information of China (English)

    张媛; 赵宝明

    2014-01-01

    Objective To observe the pathological changes of edema in rat anus and the intervention ef-fects of Guangtongxiao (广痛消)foam aerosol. Methods SD rats were induced swelling of the anus by 0.16 mL croton mixture oil. The treatment group were given Guangtongxiao (广痛消)foam aerosols into the anus. All were killed after administration In the first three days respectively, taking perianal tissue staining pro-cess and microscopic pathologic changes observed in the blank group, model group, treatment group and the con-trol group. Results The rectal mucosa of the blank group was normal, of which the model group showed in acute inflammation. With increasing of drug delivery days, the ulcer of mucosa in the treatment group gradually improved, hyperemia and edema of the submucosa showed better, with less expansion of vascular congestion. The inflammatory changes of the control group were not obvious. Conclusion Croton oil injection can cause edema and inflammatory changes in SD rat anus; Guangtongxiao(广痛消)foam aerosol can lead to anti-inflam-matory and antioncotic to anal swelling of rats .%目的:观察大鼠肛门水肿组织病理改变和广痛消泡沫气雾剂的干预作用。方法:SD大鼠用0.16 mL巴豆油混合液致肛门肿胀,治疗组肛门内给予广痛消泡沫气雾剂,分别于给药后24 h、48 h、72 h全部处死,取肛周组织进行染色处理,显微观察空白组、模型组、治疗组及对照组病理改变。结果:空白组直肠黏膜正常;模型组直肠黏膜呈急性炎症改变;治疗组随着给药天数的增加,黏膜层溃疡逐渐好转,黏膜下层充血、水肿明显改善,血管充血、扩张消失,对照组炎症改变不明显。结论:巴豆油注射可致SD大鼠肛门水肿炎性改变;广痛消泡沫气雾剂对大鼠肛门肿胀具有抗炎、消肿的作用。

  9. Blunt cardiac rupture.

    Science.gov (United States)

    Martin, T D; Flynn, T C; Rowlands, B J; Ward, R E; Fischer, R P

    1984-04-01

    Blunt injury to the heart ranges from contusion to disruption. This report comprises 14 patients seen during a 6-year period with cardiac rupture secondary to blunt trauma. Eight patients were injured in automobile accidents, two patients were injured in auto-pedestrian accidents, two were kicked in the chest by ungulates, and two sustained falls. Cardiac tamponade was suspected in ten patients. Five patients presented with prehospital cardiac arrest or arrested shortly after arrival. All underwent emergency department thoracotomy without survival. Two patients expired in the operating room during attempted cardiac repair; both had significant extracardiac injury. Seven patients survived, three had right atrial injuries, three had right ventricular injuries, and one had a left atrial injury. Cardiopulmonary bypass was not required for repair of the surviving patients. There were no significant complications from the cardiac repair. The history of significant force dispersed over a relatively small area of the precordium as in a kicking injury from an animal or steering wheel impact should alert the physician to possible cardiac rupture. Cardiac rupture should be considered in patients who present with signs of cardiac tamponade or persistent thoracic bleeding after blunt trauma. PMID:6708151

  10. Biomaterials for cardiac regeneration

    CERN Document Server

    Ruel, Marc

    2015-01-01

    This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications. This book also: Provides a valuable overview of the engineering of biomaterials for cardiac regeneration, including coverage of combined biomaterials and stem cells, as well as extracellular matrices Presents readers with multidisciplinary coverage of biomaterials for cardiac repair, including ...

  11. Mathematical cardiac electrophysiology

    CERN Document Server

    Colli Franzone, Piero; Scacchi, Simone

    2014-01-01

    This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematica...

  12. Cardiac-Specific Knockout of ETA Receptor Mitigates Paraquat-Induced Cardiac Contractile Dysfunction.

    Science.gov (United States)

    Wang, Jiaxing; Lu, Songhe; Zheng, Qijun; Hu, Nan; Yu, Wenjun; Li, Na; Liu, Min; Gao, Beilei; Zhang, Guoyong; Zhang, Yingmei; Wang, Haichang

    2016-07-01

    Paraquat (1,1'-dim ethyl-4-4'-bipyridinium dichloride), a highly toxic quaternary ammonium herbicide widely used in agriculture, exerts potent toxic prooxidant effects resulting in multi-organ failure including the lung and heart although the underlying mechanism remains elusive. Recent evidence suggests possible involvement of endothelin system in paraquat-induced acute lung injury. This study was designed to examine the role of endothelin receptor A (ETA) in paraquat-induced cardiac contractile and mitochondrial injury. Wild-type (WT) and cardiac-specific ETA receptor knockout mice were challenged to paraquat (45 mg/kg, i.p.) for 48 h prior to the assessment of echocardiographic, cardiomyocyte contractile and intracellular Ca(2+) properties, as well as apoptosis and mitochondrial damage. Levels of the mitochondrial proteins for biogenesis and oxidative phosphorylation including UCP2, HSP90 and PGC1α were evaluated. Our results revealed that paraquat elicited cardiac enlargement, mechanical anomalies including compromised echocardiographic parameters (elevated left ventricular end-systolic and end-diastolic diameters as well as reduced factional shortening), suppressed cardiomyocyte contractile function, intracellular Ca(2+) handling, overt apoptosis and mitochondrial damage. ETA receptor knockout itself failed to affect myocardial function, apoptosis, mitochondrial integrity and mitochondrial protein expression. However, ETA receptor knockout ablated or significantly attenuated paraquat-induced cardiac contractile and intracellular Ca(2+) defect, apoptosis and mitochondrial damage. Taken together, these findings revealed that endothelin system in particular the ETA receptor may be involved in paraquat-induced toxic myocardial contractile anomalies possibly related to apoptosis and mitochondrial damage. PMID:26089164

  13. Anomaly detection in online social networks

    CERN Document Server

    Savage, David; Yu, Xinghuo; Chou, Pauline; Wang, Qingmai

    2016-01-01

    Anomalies in online social networks can signify irregular, and often illegal behaviour. Anomalies in online social networks can signify irregular, and often illegal behaviour. Detection of such anomalies has been used to identify malicious individuals, including spammers, sexual predators, and online fraudsters. In this paper we survey existing computational techniques for detecting anomalies in online social networks. We characterise anomalies as being either static or dynamic, and as being labelled or unlabelled, and survey methods for detecting these different types of anomalies. We suggest that the detection of anomalies in online social networks is composed of two sub-processes; the selection and calculation of network features, and the classification of observations from this feature space. In addition, this paper provides an overview of the types of problems that anomaly detection can address and identifies key areas of future research.

  14. Urogenital tract anomalies in children with congenital anorectal malformation

    NARCIS (Netherlands)

    J.W. Hoekstra

    1991-01-01

    textabstractThe term 'imperforate anus' covers a variety of congenital anorectal malformations ranging in severity from anal stenosis to cloacal exstrophy. The clinical picture of the anorectal malformation has been known for thousands of years, during which many attempts have been made to find an e

  15. Anomaly Constraints on Monopoles and Dyons

    OpenAIRE

    Csaki, Csaba; Terning, John; Shirman, Yuri

    2010-01-01

    Fermions with magnetic charges can contribute to anomalies. We derive the axial anomaly and gauge anomalies for monopoles and dyons, and find eight new gauge anomaly cancelation conditions in a general theory with both electric and magnetic charges. As a byproduct we also extend the Zwanziger two-potential formalism to include the theta parameter, and elaborate on the condition for CP invariance in theories with fermionic dyons.

  16. [Cardiac evaluation before non-cardiac surgery].

    Science.gov (United States)

    Menzenbach, Jan; Boehm, Olaf

    2016-07-01

    Before non-cardiac surgery, evaluation of cardiac function is no frequent part of surgical treatment. European societies of anesthesiology and cardiology published consensus-guidelines in 2014 to present a reasonable approach for preoperative evaluation. This paper intends to differentiate the composite of perioperative risk and to display the guidelines methodical approach to handle it. Features to identify patients at risk from an ageing population with comorbidities, are the classification of surgical risk, functional capacity and risk indices. Application of diagnostic means, should be used adjusted to this risk estimation. Cardiac biomarkers are useful to discover risk of complications or mortality, that cannot be assessed by clinical signs. After preoperative optimization and perioperative cardiac protection, the observation of the postoperative period remains, to prohibit complications or even death. In consideration of limited resources of intensive care department, postoperative ward rounds beyond intensive care units are considered to be an appropriate instrument to avoid or recognize complications early to reduce postoperative mortality. PMID:27479258

  17. Fetal renal anomalies : diagnosis, management, and outcome

    NARCIS (Netherlands)

    Damen-Elias, Henrica Antonia Maria

    2004-01-01

    In two to three percent of fetuses structural anomalies can be found with prenatal ultrasound investigation. Anomalies of the urinary tract account for 15 to 20% of these anomalies with a detection rate of approximately of 90%. In Chapter 2, 3 and 4 we present reference curves for size and growth of

  18. Theory of Geological Anomaly in Remote Sensing

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Geological anomaly is geological body or complex body with obviously different compositions, structures or orders of genesis as compared with those in the surrounding areas. Geological anomaly, restrained by the geological factors closely associated with ore-forming process, is an important clue to ore deposits. The geological anomaly serves as a geological sign to locate ore deposits. Therefore, it is very important to study how to define the characteristics of geological anomaly and further to locate the changes in these characteristics. In this paper, the authors propose the geological anomaly based on the remote-sensing images and data, and expound systematically such image features as scale, size, boundary, morphology and genesis of geological anomalies. Then the authors introduce the categorization of the geological anomalies according to their geneses. The image characteristics of some types of geological anomalies, such as the underground geological anomaly, are also explained in detail. Based on the remote-sensing interpretation of these geological anomalies, the authors conclude that the forecasting and exploration of ore deposits should be focused on the following three aspects: (1) the analysis of geological setting and geological anomaly; (2) the analysis of circular geological anomaly, and (3) the comprehensive forecasting of ore deposits and the research into multi-source information.

  19. Prevalence of Congenital Coronary Artery Anomalies and Variants in 2697 Consecutive Patients Using 64-Detector Row Coronary CTAngiography

    International Nuclear Information System (INIS)

    Coronary artery anomalies are not common, but could be very serious. This study determines the frequency of coronary anomalies and normal variants by multi-detector-row computed tomography (MDCT). The results of cardiac MDCT study in 2697 consecutive patients were analyzed retrospectively. Acquisition was performed by a 64-detector row CT machine. Imaging results were assessed by experienced radiologists. Myocardial bridging was by far the most frequent coronary variant (n = 576, 21.3%). Eighty-three subjects (3.1%) showed other coronary anomalies and variants. Anomalies of origination and course of the left main coronary artery (LMCA) were detected in 1.09% of the subjects. The frequency of these anomalies in the right coronary artery (RCA), left circumflex artery (LCx), left anterior descending artery (LAD), posterior descending artery (PDA) and obtuse marginal (OM) artery were 1.24%, 0.33%, 0.1%, 0.07% and 0.03%, respectively. The single coronary pattern was seen in 0.18% and coronary fistulas in 0.07%. Based on the fact that coronary CT-angiography using MDCT can display different coronary anomalies, this study shows similar results to other reports on the subject. Future advances in the performance of CT machines will further improve the quality of CT-based cardiac imaging

  20. Prevalence of Congenital Coronary Artery Anomalies and Variants in 2697 Consecutive Patients Using 64-Detector Row Coronary CTAngiography

    Directory of Open Access Journals (Sweden)

    Farzaneh Fattahi Masrour

    2012-01-01

    Full Text Available Background: Coronary artery anomalies are not common, but could be very serious.Objectives: This study determines the frequency of coronary anomalies and normal variants by multi-detector-row computed tomography (MDCT.Patients and Methods: The results of cardiac MDCT study in 2697 consecutive patients were analyzed retrospectively. Acquisition was performed by a 64-detector row CT machine. Imaging results were assessed by experienced radiologists.Results: Myocardial bridging was by far the most frequent coronary variant (n = 576, 21.3%. Eighty-three subjects (3.1% showed other coronary anomalies and variants. Anomalies of origination and course of the left main coronary artery (LMCA were detected in 1.09% of the subjects. The frequency of these anomalies in the right coronary artery (RCA, left circumflex artery (LCx, left anterior descending artery (LAD, posterior descending artery (PDA and obtuse marginal (OM artery were 1.24%, 0.33%, 0.1%, 0.07% and 0.03%, respectively. The single coronary pattern was seen in 0.18% and coronary fistulas in 0.07%.Conclusion: Based on the fact that coronary CT-angiography using MDCT can display different coronary anomalies, this study shows similar results to other reports on the subject. Future advances in the performance of CT machines will further improve the quality of CT-based cardiac imaging.Keywords: Coronary Artery Disease,Tomography,X-Ray Computed,Patients

  1. Folic Acid Reverses Nitric Oxide Synthase Uncoupling and Prevents Cardiac Dysfunction in Insulin Resistance: Role of Ca2+/Calmodulin-Activated Protein Kinase II

    OpenAIRE

    Roe, Nathan D.; He, Emily Y.; Wu, Zhenbiao; Ren, Jun

    2013-01-01

    Nitric oxide synthase (NOS) may be uncoupled to produce superoxide rather than nitric oxide (NO) under pathological conditions such as diabetes mellitus and insulin resistance, leading to cardiac contractile anomalies. Nonetheless, the role of NOS uncoupling in insulin resistance-induced cardiac dysfunction remains elusive. Given that folic acid may produce beneficial effect for cardiac insufficiency partially through its NOS recoupling capacity, this study was designed to evaluate the effect...

  2. Tracheal agenesis with broncho-esophageal fistula in VACTERL / TACRD association

    Directory of Open Access Journals (Sweden)

    Suresh R. S. Mandrekar

    2013-01-01

    Full Text Available Tracheal agenesis (TA is an extremely rare malformation. We report here autopsy findings in a case of TA with bronchoesophageal fistula of Floyd type III. The other malformations present included laryngeal atresia, Right lung hypolobulation, ventricular septal defect in membranous portion, bilateral cystic renal dysplasia, spleninculus, Meckel′s diverticulum, and imperforate anus. The constellations of malformations present in our case have overlapping features with Vertebral anomalies, Anal atresia, Cardiovascular anomalies, Tracheo-esophageal fistula, Esophageal atresia, Renal anomalies, Limb anomalies and Tracheal atresia or laryngo tracheal atresia, Cardiac anomalies, Renal anomalies, Duodenal atresia association described previously in the literature.

  3. Survey of Anomaly Detection Methods

    Energy Technology Data Exchange (ETDEWEB)

    Ng, B

    2006-10-12

    This survey defines the problem of anomaly detection and provides an overview of existing methods. The methods are categorized into two general classes: generative and discriminative. A generative approach involves building a model that represents the joint distribution of the input features and the output labels of system behavior (e.g., normal or anomalous) then applies the model to formulate a decision rule for detecting anomalies. On the other hand, a discriminative approach aims directly to find the decision rule, with the smallest error rate, that distinguishes between normal and anomalous behavior. For each approach, we will give an overview of popular techniques and provide references to state-of-the-art applications.

  4. Calculation of the commutator anomaly

    International Nuclear Information System (INIS)

    It is well-known that, for the non-Abelian gauge theory coupled to the chiral fermions, which is described by a Lagrangian, the anomaly of the non-Abelian current is given by the descent form of the Chern-Simon five form; D*Ja = (-1/24π2)tr[d(AdA + 1/2A3)], where A = Aμdxμ = -itaAμadxμ. Recently, Faddeev argued that, for such an anomalous system, the gauge symmetry would be represented in a generalized sense of projective representation; V(g1)V(g2)Ψ(A) = exp[iα2(g1, g2; A)] X V(g1g2)Ψ(A), where Ψ(A) is the wave functional and the phase factor α2 depends on both the group elements and the gauge field configuration A. Here, it is convenient to consider the infinitesimal version of the above argument. The generator of infinitesimal gauge transformation in the temporal gauge A0 = 0 is given by Ga(x) = δiEia + gfabcAibEic - gΨ-barγ0taΨ, and the infinitesimal form of the previous product rule can be written as the equal time commutation relation; [Ga(x), Gb(y)] = ifabcGc(x)δ3(x-y) + ab(x,y,A), where is related to α2. In this equation, the first term is what is expected as the normal commutation relation of the generator, while the second term is an anomaly, which is designated here as the commutator anomaly. Then the present study concentrates on operations to determine the anomaly term. (Nogami, A.)

  5. Quantum tunneling and trace anomaly

    International Nuclear Information System (INIS)

    We compute the corrections, using the tunneling formalism based on a quantum WKB approach, to the Hawking temperature and Bekenstein-Hawking entropy for the Schwarzschild black hole. The results are related to the trace anomaly and are shown to be equivalent to findings inferred from Hawking's original calculation based on path integrals using zeta function regularization. Finally, exploiting the corrected temperature and periodicity arguments we also find the modification to the original Schwarzschild metric which captures the effect of quantum corrections.

  6. KIDNEY ANOMALIES: HORSE SHOE KIDNEY

    OpenAIRE

    Hemalatha; Komarabattina; Nageshwar Rao; Kotikala Prabhakara

    2015-01-01

    INTRODUCTION : Horse Shoe Kidney was first recognized during an autopsy by De Carpi in 1521. This anomaly consists of two distinct renal masses lying vertically on either side of the midline and connected at their respective lower poles by a parenchymatous or fibrous isthmus that crosses the mid pl ane of the body. This isthmus lies at the level of 4th lumbar vertebra just beneath the origin of inferior mesenteric ...

  7. Prenatal diagnosis of cloacal anomaly.

    Science.gov (United States)

    Cacciaguerra, S; Lo Presti, L; Di Leo, L; Grasso, S; Gangarossa, S; Di Benedetto, V; Di Benedetto, A

    1998-02-01

    The authors present a case of prenatal diagnosis of cloacal anomaly, characterized by the presence of oligohydramnios and cystic pelvic mass with changing features during observation. Postnatal study confirmed the presence of a recto-cloacal fistula, with a high confluence of the urinary, genital and intestinal systems. Both parents had a chromosome 9 inversion (p11q13), but the child was chromosomally normal. PMID:9561584

  8. Schottky Anomaly and Hadronic Spectrum

    CERN Document Server

    Biswas, Aritra; Sinha, Nita

    2015-01-01

    We show that the hadronic "heat capacity" calculated as a function of temperature may be used to infer the possible presence of different scales underlying the dynamical structure of hadronic resonances using the phenomenon of Schottky anomaly. We first demonstrate this possibility with well known meson spectrum in various channels and comment on the possibility of using this method as a diagnostic to distinguish the exotic states.

  9. Cardiac metabolism and arrhythmias

    OpenAIRE

    Barth, Andreas S.; Tomaselli, Gordon F.

    2009-01-01

    Sudden cardiac death remains a leading cause of mortality in the Western world, accounting for up to 20% of all deaths in the U.S.1, 2 The major causes of sudden cardiac death in adults age 35 and older are coronary artery disease (70–80%) and dilated cardiomyopathy (10–15%).3 At the molecular level, a wide variety of mechanisms contribute to arrhythmias that cause sudden cardiac death, ranging from genetic predisposition (rare mutations and common polymorphisms in ion channels and structural...

  10. [Cardiac Rehabilitation 2015].

    Science.gov (United States)

    Hoffmann, Andreas

    2015-11-25

    The goals of cardiac rehabilitation are (re-)conditioning and secondary prevention in patients with heart disease or an elevated cardiovascular risk profile. Rehabilitation is based on motivation through education, on adapted physical activity, instruction of relaxation techniques, psychological support and optimized medication. It is performed preferably in groups either in outpatient or inpatient settings. The Swiss working group on cardiac rehabilitation provides a network of institutions with regular quality auditing. Positive effects of rehabilitation programs on mortality and morbidity have been established by numerous studies. Although a majority of patients after cardiac surgery are being referred to rehabilitation, these services are notoriously underused after catheter procedures. PMID:26602848

  11. Comprehensive cardiac rehabilitation

    DEFF Research Database (Denmark)

    Kruse, Marie; Hochstrasser, Stefan; Zwisler, Ann-Dorthe O;

    2006-01-01

    OBJECTIVES: The costs of comprehensive cardiac rehabilitation are established and compared to the corresponding costs of usual care. The effect on health-related quality of life is analyzed. METHODS: An unprecedented and very detailed cost assessment was carried out, as no guidelines existed for...... uncertain and may be as high as euro 1.877. CONCLUSIONS: Comprehensive cardiac rehabilitation is more costly than usual care, and the higher costs are not outweighed by a quality of life gain. Comprehensive cardiac rehabilitation is, therefore, not cost-effective....

  12. Anomaly mediation in superstring theory

    Energy Technology Data Exchange (ETDEWEB)

    Conlon, Joseph P. [Rudolf Peierls Center for Theoretical Physics, Oxford (United Kingdom); Balliol College, Oxford (United Kingdom); Goodsell, Mark [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Palti, Eran [Centre de Physique Theoretique, Ecole Polytechnique, CNRS, Palaiseau (France)

    2010-08-15

    We study anomaly mediated supersymmetry breaking in type IIB string theory and use our results to test the supergravity formula for anomaly mediated gaugino masses. We compute 1-loop gaugino masses for models of D3-branes on orbifold singularities with 3-form fluxes by calculating the annulus correlator of 3-form flux and two gauginos in the zero momentum limit. Consistent with supergravity expectations we find both anomalous and running contributions to 1-loop gaugino masses. For background Neveu-Schwarz H-flux we find an exact match with the supergravity formula. For Ramond-Ramond flux there is an off-shell ambiguity that precludes a full matching. The anomaly mediated gaugino masses, while determined by the infrared spectrum, arise from an explicit sum over UV open string winding modes. We also calculate brane-to-brane tree-level gravity mediated gaugino masses and show that there are two contributions coming from the dilaton and from the twisted modes, which are suppressed by the full T{sup 6} volume and the untwisted T{sup 2} volume respectively. (orig.)

  13. Anomaly mediation in superstring theory

    International Nuclear Information System (INIS)

    We study anomaly mediated supersymmetry breaking in type IIB string theory and use our results to test the supergravity formula for anomaly mediated gaugino masses. We compute 1-loop gaugino masses for models of D3-branes on orbifold singularities with 3-form fluxes by calculating the annulus correlator of 3-form flux and two gauginos in the zero momentum limit. Consistent with supergravity expectations we find both anomalous and running contributions to 1-loop gaugino masses. For background Neveu-Schwarz H-flux we find an exact match with the supergravity formula. For Ramond-Ramond flux there is an off-shell ambiguity that precludes a full matching. The anomaly mediated gaugino masses, while determined by the infrared spectrum, arise from an explicit sum over UV open string winding modes. We also calculate brane-to-brane tree-level gravity mediated gaugino masses and show that there are two contributions coming from the dilaton and from the twisted modes, which are suppressed by the full T6 volume and the untwisted T2 volume respectively. (orig.)

  14. Double Coronary Artery Anomaly in an Elderly Asymptomatic Patient with Positive Electrocardiogram Stress Test

    Directory of Open Access Journals (Sweden)

    Giuseppe Cannavale

    2013-01-01

    Full Text Available Malignant coronary artery anomalies and myocardial bridging are more common findings in young patients with cardiac symptoms, but these two associated yet different types of anomalies in an elderly patient has been rarely described. The following case describes the diagnostic use of 128-slice coronary-computed tomography images of an 82-year-old male, former professional soccer player, who reached the age of 82 years without any symptoms of coronary heart disease. In this patient, an association of a malignant coronary artery anomaly of origin and course (left descending coronary artery originating from the right sinus of valsalva running between the aorta and the right ventricular outflow tract, together with a long myocardial bridging over the obtuse marginal branch was diagnosed by multi-slice computed tomography thanks to an initial positive electrocardiogram screening stress test.

  15. Molecular Basis of Cardiac Myxomas

    Directory of Open Access Journals (Sweden)

    Pooja Singhal

    2014-01-01

    Full Text Available Cardiac tumors are rare, and of these, primary cardiac tumors are even rarer. Metastatic cardiac tumors are about 100 times more common than the primary tumors. About 90% of primary cardiac tumors are benign, and of these the most common are cardiac myxomas. Approximately 12% of primary cardiac tumors are completely asymptomatic while others present with one or more signs and symptoms of the classical triad of hemodynamic changes due to intracardiac obstruction, embolism and nonspecific constitutional symptoms. Echocardiography is highly sensitive and specific in detecting cardiac tumors. Other helpful investigations are chest X-rays, magnetic resonance imaging and computerized tomography scan. Surgical excision is the treatment of choice for primary cardiac tumors and is usually associated with a good prognosis. This review article will focus on the general features of benign cardiac tumors with an emphasis on cardiac myxomas and their molecular basis.

  16. Multimodality cardiac imaging of a double chambered right ventricle with intrapulmonary shunting: a case report

    Directory of Open Access Journals (Sweden)

    Kha Lan-Chau

    2012-09-01

    Full Text Available Abstract Background Double chambered right ventricle (DCRV is a relatively rare congenital heart disease, characterized by the abnormal division of the right ventricle into a high-pressure inlet and low-pressure outlet by anomalous muscle bundles. Extra-cardiac right-to-left shunts may present with clinical symptoms in adulthood and should be sought in patients with previous cavo-pulmonary shunt procedures. Case presentation We report a case of DCRV in a 29 year old Caucasian male presenting in adulthood with a right-to-left shunt secondary to venous collaterals, following cavopulmonary anastomosis for congenital pulmonary atresia and hypoplastic right ventricle. Conclusion Multimodality cardiac imaging using echocardiography, cardiac CT, cardiac MRI and cardiac catheterization is often required for complete characterization of complex congenital heart anomalies in adulthood.

  17. MAGNETIC ANOMALY LINEATION AND FRACTURE ZONE IN ENDERBY BASIN DEDUCED FROM GEOMAGNETIC ANOMALY FIELD VECTOR

    OpenAIRE

    ノギ, ヨシフミ; セアマ, ノブカズ; イセザキ, ノブヒロ; フクダ, ヨウイチ; Yoshifumi, NOGI; Nobukazu, SEAMA; Nobuhiro, ISEZAKI; Yoichi, FUKUDA

    1995-01-01

    The formation of magnetic anomaly lineations and fracture zones in Enderby Basin (10°E-80°E), Southern Indian Ocean, are vital to understanding process of the Gondwana breakup. Vector anomalies of the geomagnetic field were obtained during the 30th, 31st, 32nd, and 33rd Japanese Antarctic Research Expeditions. The strikes of the magnetic anomaly lineations and fracture zones were deduced from vector geomagnetic anomaly field data as well as seasurface and satellite gravity anomalies. We surmi...

  18. Automatic Implantable Cardiac Defibrillator

    Medline Plus

    Full Text Available Automatic Implantable Cardiac Defibrillator February 19, 2009 Halifax Health Medical Center, Daytona Beach, FL Welcome to Halifax Health Daytona Beach, Florida. Over the next hour you' ...

  19. Sudden Cardiac Arrest

    Science.gov (United States)

    ... scan, or MUGA, which shows how well your heart is pumping blood. Magnetic resonance imaging (MRI) which gives doctors detailed pictures of your heart. How is SCA treated? Sudden cardiac arrest should ...

  20. Sudden Cardiac Arrest

    Science.gov (United States)

    ... Heart Risk Factors & Prevention Heart Diseases & Disorders Atrial Fibrillation (AFib) Sudden Cardiac Arrest (SCA) SCA: Who's At Risk? Prevention of SCA What Causes SCA? SCA Awareness Atrial Flutter Heart Block Heart Failure Sick Sinus Syndrome Substances & Heart Rhythm Disorders Symptoms & ...

  1. Cardiac Risk Assessment

    Science.gov (United States)

    ... to assess cardiac risk include: High-sensitivity C-reactive protein (hs-CRP) : Studies have shown that measuring ... LDL-C but does not respond to typical strategies to lower LDL-C such as diet, exercise, ...

  2. Cardiac arrest - cardiopulmonary resuscitation

    Institute of Scientific and Technical Information of China (English)

    Basri Lenjani; Besnik Elshani; Nehat Baftiu; Kelmend Pallaska; Kadir Hyseni; Njazi Gashi; Nexhbedin Karemani; Ilaz Bunjaku; Taxhidin Zaimi; Arianit Jakupi

    2014-01-01

    Objective:To investigate application of cardiopulmonary resuscitation(CPR) measures within the golden minutes inEurope.Methods:The material was taken from theUniversityClinical Center ofKosovo -EmergencyCentre inPristina, during the two(2) year period(2010-2011).The collected date belong to the patients with cardiac arrest have been recorded in the patients' log book protocol at the emergency clinic.Results:During the2010 to2011 in the emergency center of theCUCK inPristina have been treated a total of269 patients with cardiac arrest, of whom159 or59.1% have been treated in2010, and110 patients or40.9% in2011.Of the269 patients treated in the emergency centre,93 or34.6% have exited lethally in the emergency centre, and176 or 65.4% have been transferred to other clinics.In the total number of patients with cardiac arrest, males have dominated with186 cases, or69.1%.The average age of patients included in the survey was56.7 year oldSD±16.0 years.Of the269 patients with cardiac arrest, defibrillation has been applied for93 or34.6% of patients.In the outpatient settings defibrillation has been applied for3 or3.2% of patients.Patients were defibrillated with application of one to four shocks. Of27 cases with who have survived cardiac arrest, none of them have suffered cardiac arrest at home,3 or11.1% of them have suffered cardiac arrest on the street, and24 or88.9% of them have suffered cardiac arrest in the hospital.5 out of27 patients survived have ended with neurological impairment.Cardiac arrest cases were present during all days of the week, but frequently most reported cases have been onMonday with32.0% of cases, and onFriday with24.5% of cases. Conclusions:All survivors from cardiac arrest have received appropriate medical assistance within10 min from attack, which implies that if cardiac arrest occurs near an institution health care(with an opportunity to provide the emergent health care) the rate of survival is higher.

  3. Awareness in cardiac anesthesia.

    LENUS (Irish Health Repository)

    Serfontein, Leon

    2010-02-01

    Cardiac surgery represents a sub-group of patients at significantly increased risk of intraoperative awareness. Relatively few recent publications have targeted the topic of awareness in this group. The aim of this review is to identify areas of awareness research that may equally be extrapolated to cardiac anesthesia in the attempt to increase understanding of the nature and significance of this scenario and how to reduce it.

  4. Safety in cardiac surgery

    OpenAIRE

    Siregar, S.

    2013-01-01

    The monitoring of safety in cardiac surgery is a complex process, which involves many clinical, practical, methodological and statistical issues. The objective of this thesis was to measure and to compare safety in cardiac surgery in The Netherlands using the Netherlands Association for Cardio-Thoracic Surgery (NVT) database. The safety of care is usually measured using patient outcomes. If outcomes are not available, the process and structure of care may be used. Outcomes should be adjusted ...

  5. Cardiac rehabilitation in Germany.

    Science.gov (United States)

    Karoff, Marthin; Held, Klaus; Bjarnason-Wehrens, Birna

    2007-02-01

    The purpose of this review is to give an overview of the rehabilitation measures provided for cardiac patients in Germany and to outline its legal basis and outcomes. In Germany the cardiac rehabilitation system is different from rehabilitation measures in other European countries. Cardiac rehabilitation in Germany since 1885 is based on specific laws and the regulations of insurance providers. Cardiac rehabilitation has predominantly been offered as an inpatient service, but has recently been complemented by outpatient services. A general agreement on the different indications for offering these two services has yet to be reached. Cardiac rehabilitation is mainly offered after an acute cardiac event and bypass surgery. It is also indicated in severe heart failure and special cases of percutaneous coronary intervention. Most patients are men (>65%) and the age at which events occur is increasing. The benefits obtained during the 3-4 weeks after an acute event, and confirmed in numerous studies, are often later lost under 'usual care' conditions. Many attempts have been made by rehabilitation institutions to improve this deficit by providing intensive aftercare. One instrument set up to achieve this is the nationwide institution currently comprising more than 6000 heart groups with approximately 120000 outpatients. After coronary artery bypass grafting or acute coronary syndrome cardiac rehabilitation can usually be started within 10 days. The multidisciplinary rehabilitation team consists of cardiologists, psychologists, exercise therapists, social workers, nutritionists and nurses. The positive effects of cardiac rehabilitation are also important economically, for example, for the improvement of secondary prevention and vocational integration. PMID:17301623

  6. Ranolazine in Cardiac Arrhythmia.

    Science.gov (United States)

    Saad, Marwan; Mahmoud, Ahmed; Elgendy, Islam Y; Richard Conti, C

    2016-03-01

    Ranolazine utilization in the management of refractory angina has been established by multiple randomized clinical studies. However, there is growing evidence showing an evolving role in the field of cardiac arrhythmias. Multiple experimental and clinical studies have evaluated the role of ranolazine in prevention and management of atrial fibrillation, with ongoing studies on its role in ventricular arrhythmias. In this review, we will discuss the pharmacological, experimental, and clinical evidence behind ranolazine use in the management of various cardiac arrhythmias. PMID:26459200

  7. Cardiac tumours in infancy

    OpenAIRE

    Yadava, O.P.

    2012-01-01

    Cardiac tumours in infancy are rare and are mostly benign with rhabdomyomas, fibromas and teratomas accounting for the majority. The presentation depends on size and location of the mass as they tend to cause cavity obstruction or arrhythmias. Most rhabdomyomas tend to regress spontaneously but fibromas and teratomas generally require surgical intervention for severe haemodynamic or arrhythmic complications. Other relatively rare cardiac tumours too are discussed along with an Indian perspect...

  8. Cardiac Image Registration

    Directory of Open Access Journals (Sweden)

    2008-09-01

    Full Text Available Long procedure time and somewhat suboptimal results hinder the widespread use of catheter ablation of complex arrhythmias such as atrial fibrillation (AF. Due to lack of contrast differentiation between the area of interest and surrounding structures in a moving organ like heart, there is a lack of proper intraprocedural guidance using current imaging techniques for ablation. Cardiac image registration is currently under investigation and is in clinical use for AF ablation. Cardiac image registration, which involves integration of two images in the context of left atrium (LA, is intermodal, with the acquired image and the real-time reference image residing in different image spaces, and involves optimization, where one image space is transformed into the other. Unlike rigid body registration, cardiac image registration is unique and challenging due to cardiac motion during the cardiac cycle and due to respiration. This review addresses the basic principles of the emerging technique of registration and the inherent limitations as they relate to cardiac imaging and registration.

  9. Cardiac Image Registration

    Directory of Open Access Journals (Sweden)

    Jasbir Sra

    2008-09-01

    Full Text Available Long procedure time and somewhat suboptimal results hinder the widespread use of catheter ablation of complex arrhythmias such as atrial fibrillation (AF. Due to lack of contrast differentiation between the area of interest and surrounding structures in a moving organ like heart, there is a lack of proper intraprocedural guidance using current imaging techniques for ablation. Cardiac image registration is currently under investigation and is in clinical use for AF ablation. Cardiac image registration, which involves integration of two images in the context of the left atrium (LA, is intermodal, with the acquired image and the real-time reference image residing in different image spaces, and involves optimization, where one image space is transformed into the other. Unlike rigid body registration, cardiac image registration is unique and challenging due to cardiac motion during the cardiac cycle and due to respiration. This review addresses the basic principles of the emerging technique of registration and the inherent limitations as they relate to cardiac imaging and registration.

  10. Postoperative cardiac arrest due to cardiac surgery complications

    International Nuclear Information System (INIS)

    To examine the role of anesthetists in the management of cardiac arrest occurring in association with cardiac anesthesia. In this retrospective study we studied the potential performances for each of the relevant incidents among 712 patients undergoing cardiac operations at Golestan and Naft Hospitals Ahwaz between November 2006 and July 2008. Out of total 712 patients undergoing cardiac surgery, cardiac arrest occurred in 28 cases (3.9%) due to different postoperative complications. This included massive bleeding (50% of cardiac arrest cases, 1.9% of patients); pulseless supra ventricular tachycardia (28.5% of cardiac arrest cases, 1.1% of patients); Heart Failure (7% of cardiac arrest cases, 0.2% of patients); Aorta Arc Rapture (3.5% of cardiac arrest cases, 0.1% of patients); Tamponade due to pericardial effusion (3.5% of cardiac arrest cases, 0.1% of total patients); Right Atrium Rupture (3.5% of cardiac arrest cases, 0.1% of patients) were detected after cardiac surgery. Out of 28 cases 7 deaths occurred (25% of cardiac arrest cases, 0.1% of patients). The most prevalent reason for cardiac arrest during post operative phase was massive bleeding (50%) followed by pulseless supra ventricular tachycardia (28.5%). Six patients had some morbidity and the remaining 15 patients recovered. There are often multiple contributing factors to a cardiac arrest under cardiac anesthesia, as much a complete systematic assessment of the patient, equipment, and drugs should be completed. We also found that the diagnosis and management of cardiac arrest in association with cardiac anesthesia differs considerably from that encountered elsewhere. (author)

  11. Easily magnetic anomalies earthquake prediction

    Directory of Open Access Journals (Sweden)

    Jiang Min

    2016-01-01

    Full Text Available Low power consumption long time offset magnetic field detector (earthquake prediction .The design of the hardware circuit of the magnetic field detector seismic geomagnetic acquisition and pre processing module mainly includes. Electronic compass, compass. monitoring device while the magnetic azimuth for monitoring and analyzing the object, GSM, but it can also be applied to other seismic precursor information analysis, such as earthquake precursory infrasound abnormality, only need infrasound abnormality intelligent sensor replace geomagnetic anomaly intelligent sensor, and modify the relevant parameters can be.

  12. Hot Flow Anomalies at Venus

    Science.gov (United States)

    Collinson, G. A.; Sibeck, David Gary; Boardsen, Scott A.; Moore, Tom; Barabash, S.; Masters, A.; Shane, N.; Slavin, J.A.; Coates, A.J.; Zhang, T. L.; Sarantos, M.

    2012-01-01

    We present a multi-instrument study of a hot flow anomaly (HFA) observed by the Venus Express spacecraft in the Venusian foreshock, on 22 March 2008, incorporating both Venus Express Magnetometer and Analyzer of Space Plasmas and Energetic Atoms (ASPERA) plasma observations. Centered on an interplanetary magnetic field discontinuity with inward convective motional electric fields on both sides, with a decreased core field strength, ion observations consistent with a flow deflection, and bounded by compressive heated edges, the properties of this event are consistent with those of HFAs observed at other planets within the solar system.

  13. Chiral Anomaly in Contorted Spacetimes

    CERN Document Server

    Mielke, E W

    1999-01-01

    The Dirac equation in Riemann-Cartan spacetimes with torsion is reconsidered. As is well-known, only the axial covector torsion $A$, a one-form, couples to massive Dirac fields. Using diagrammatic techniques, we show that besides the familiar Riemannian term only the Pontrjagin type four-form $dA\\wedge dA$ does arise additionally in the chiral anomaly, but not the Nieh-Yan term $d ^* A$, as has been claimed recently. Implications for cosmic strings in Einstein-Cartan theory as well as for Ashtekar's canonical approach to quantum gravity are discussed.

  14. Prenatal sonographic diagnosis of focal musculoskeletal anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jung-Kyu; Cho, Jeong-Yeon; Choi, Jong-Sun [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2003-12-15

    Focal musculoskeletal anomalies vary, and can manifest as part of a syndrome or be accompanied by numerous other conditions such as genetic disorders, karyotype abnormalities, central nervous system anomalies and other skeletal anomalies, lsolated focal musculoskeletal anomaly does, however, also occur; its early prenatal diagnosis is important in deciding prenatal care, and also helps in counseling parents about the postnatal effects of numerous possible associated anomalies. We have encountered 50 cases involving focal musculoskeletal anomalies, including total limb dysplasia [radial ray abnormality (n=3), mesomelic dysplasia (n=1)]; anomalies of the hand [polydactyly (n=8), syndactyly (n=3), ectrodactyly (n=1), clinodactyly (n=6), clenched hand (n=5)]; anomalies of the foot [clubfoot (n=10), rockerbottom foot (n=5), sandal gap deformity (n=1), curly toe (n=2)]; amniotic band syndrome (n=3); and anomalies of the focal spine [block vertebra (n=1), hemivertebra (n=1)]. Among these 50 cases, five [polydactyly (n=1), syndactyly (n=2) and curly toe (n=2) were confirmed by postnatal physical evaluation, two (focal spine anomalies) were diagnosed after postnatal radiologic examination, and the remaining 43 were proven at autopsy. For each condition, we describe the prenatal sonographic findings, and include a brief review.

  15. Qualitative research on the living quality of patients with low rectal cancer after anus preservation operation%低位直肠癌保肛术后患者生活质量的质性研究

    Institute of Scientific and Technical Information of China (English)

    侯华芳; 花霞; 何剑

    2014-01-01

    Objective To study the sujectect evalution of living quality,analysis of relevant factors,improve the living quality of the patients with low rectal concer after anus preservation. Methods Adopted purposive sampling method to select 9 low rectal cancer patients in our hospital with postoperative semi-structured interviews ,Colaizzi method to analysis data. Re-sults The subjective experience on living quality of the patients with low rectal cancer after anus preservation,incontinence,the change of the demand of self-care knowledge,self-efficacy,self feelings of burden,anxiety,and pessimistic. Conclusion Fecal incontinence brought great distress on life and psychological to the patients with low rectal cancer after anus preservation ,seri-ously affected the living quality of patients,in order to improve living quality of the patients, nursing intervention should be giv-en in time to help patients gradually to return normal defecation.%目的:了解低位直肠癌保肛术后患者对生活质量的主观评价,分析相关因素,提高患者生活质量。方法采用目的抽样法选取我院9例低位直肠癌保肛术后患者进行半结构性访谈,Colaizzi法分析资料。结果低位直肠癌保肛术后患者生活质量的主观体验:大便失禁的困扰、自我护理知识的需求、自我效能的改变、自我感受负担、焦虑和悲观。结论大便失禁给低位直肠癌保肛术后患者生活和心理带来极大的困扰,严重影响患者的生活质量,为提高患者术后生活质量,应及时给予护理干预,帮助患者逐步恢复正常排便。

  16. Detection of Cardiovascular Anomalies: An Observer-Based Approach

    KAUST Repository

    Ledezma, Fernando

    2012-07-01

    In this thesis, a methodology for the detection of anomalies in the cardiovascular system is presented. The cardiovascular system is one of the most fascinating and complex physiological systems. Nowadays, cardiovascular diseases constitute one of the most important causes of mortality in the world. For instance, an estimate of 17.3 million people died in 2008 from cardiovascular diseases. Therefore, many studies have been devoted to modeling the cardiovascular system in order to better understand its behavior and find new reliable diagnosis techniques. The lumped parameter model of the cardiovascular system proposed in [1] is restructured using a hybrid systems approach in order to include a discrete input vector that represents the influence of the mitral and aortic valves in the different phases of the cardiac cycle. Parting from this model, a Taylor expansion around the nominal values of a vector of parameters is conducted. This expansion serves as the foundation for a component fault detection process to detect changes in the physiological parameters of the cardiovascular system which could be associated with cardiovascular anomalies such as atherosclerosis, aneurysm, high blood pressure, etc. An Extended Kalman Filter is used in order to achieve a joint estimation of the state vector and the changes in the considered parameters. Finally, a bank of filters is, as in [2], used in order to detect the appearance of heart valve diseases, particularly stenosis and regurgitation. The first numerical results obtained are presented.

  17. A study of dental anomalies

    International Nuclear Information System (INIS)

    The purpose of this study was to find out the prevalence of dental anomalies in 600 normal persons (male:363, female:237) at age 14 to 39 years, through history taking, oral examination, and radiographic observations of subjects. The obtained results were as follows: 1. The prevalence of individual dental anomalies were as follows; Congenitally missing teeth 7%; supernumerary teeth 1.33%; ectopic eruption 8.50%; transposition 0.33%; rotation 23.67%; microdontia 11.16% (peg lateral is 5.33%; third molar 5.83%); prolonged retention of deciduous teeth 1.33%; crowding 49.83%; and spacing 15.17%. 2. Alterations in numbers of teeth : The most frequently missing teeth were mandibular lateral incisors, followed by mandibular second premolars and maxillary second premolars. In numbers of congenitally missing teeth per person, 52.38% had one missing tooth and 30.95% had two missing teeth. In supernumerary teeth, there was higher rate in male than in female. Most supernumerary teeth were mesiodens of median area in maxilla and the eruption pattern of that teeth generally was unerupted state. 3. In transposition, exchange of position of teeth involved the canine and first premolar. 4. Congenital missing rate of permanent successors in prolonged retention of deciduous teeth was 69.23%. 5. Crowding and spacing had respectively higher rate in mandible and in maxilla.

  18. A study of dental anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Sook; Kim, Jae Duck [Dept. of Oral Radiology, College of Dentistry, Chosun University, Kwangju (Korea, Republic of)

    1993-08-15

    The purpose of this study was to find out the prevalence of dental anomalies in 600 normal persons (male:363, female:237) at age 14 to 39 years, through history taking, oral examination, and radiographic observations of subjects. The obtained results were as follows: 1. The prevalence of individual dental anomalies were as follows; Congenitally missing teeth 7%; supernumerary teeth 1.33%; ectopic eruption 8.50%; transposition 0.33%; rotation 23.67%; microdontia 11.16% (peg lateral is 5.33%; third molar 5.83%); prolonged retention of deciduous teeth 1.33%; crowding 49.83%; and spacing 15.17%. 2. Alterations in numbers of teeth : The most frequently missing teeth were mandibular lateral incisors, followed by mandibular second premolars and maxillary second premolars. In numbers of congenitally missing teeth per person, 52.38% had one missing tooth and 30.95% had two missing teeth. In supernumerary teeth, there was higher rate in male than in female. Most supernumerary teeth were mesiodens of median area in maxilla and the eruption pattern of that teeth generally was unerupted state. 3. In transposition, exchange of position of teeth involved the canine and first premolar. 4. Congenital missing rate of permanent successors in prolonged retention of deciduous teeth was 69.23%. 5. Crowding and spacing had respectively higher rate in mandible and in maxilla.

  19. Conductivity Anomalies in Central Europe

    Science.gov (United States)

    Neska, Anne

    2016-01-01

    This paper is a review of studies which, by applying the magnetotelluric, geomagnetic deep sounding, and magnetovariational sounding methods (the latter refers to usage of the horizontal magnetic tensor), investigate Central Europe for zones of enhanced electrical conductivity. The study areas comprise the region of the Trans-European Suture Zone (i.e. the south Baltic region and Poland), the North German Basin, the German and Czech Variscides, the Pannonian Basin (Hungary), and the Polish, Slovakian, Ukrainian, and Romanian Carpathians. This part of the world is well investigated in terms of data coverage and of the density of published studies, whereas the certainty that the results lead to comprehensive interpretations varies within the reviewed literature. A comparison of spatially coincident or adjacent studies reveals the important role that the data coverage of a distinct conductivity anomaly plays for the consistency of results. The encountered conductivity anomalies are understood as linked to basin sediments, asthenospheric upwelling, large differences in lithospheric age, and—this concerns most of them, which all concentrate in the middle crust—tectonic boundaries that developed during all mountain building phases that have taken place on the continent.

  20. In utero oxcarbazepine and a withdrawal syndrome, anomalies, and hyponatremia.

    Science.gov (United States)

    Rolnitsky, Asaph; Merlob, Paul; Klinger, Gil

    2013-06-01

    Oxcarbazepine is an antiepileptic agent that has been used during pregnancy, although its safety during pregnancy has not been sufficiently established. This article presents an infant born with renal and cardiac malformations who developed a withdrawal syndrome and hyponatremia following in utero exposure to oxcarbazepine. The infant was born at 35 weeks' gestation by urgent cesarean section to a mother in status epilepticus who had been treated with oxcarbazepine throughout her pregnancy. Evaluation for congenital anomalies identified mild aortic stenosis, a bicuspid aortic valve, patent foramen ovale, patent ductus arteriosus, and severe left hydronephrosis due to left ureteropelvic junction stenosis. On the third day of life the infant developed clinical signs of a withdrawal syndrome, which peaked on day 7 and resolved by day 12. Transient hyponatremia resolved by day 8 of life. Follow-up showed normal development at 15 months. The association of a withdrawal syndrome with oxcarbazepine exposure has not been previously reported. The hyponatremia is consistent with adult reports. The possible association of oxcarbazepine with renal and cardiac malformations requires further confirmation. PMID:23668873

  1. Anomaly-Free Supergravities in Six Dimensions

    CERN Document Server

    Avramis, S D

    2006-01-01

    This thesis reviews minimal N=2 chiral supergravities coupled to matter in six dimensions with emphasis on anomaly cancellation. In general, six-dimensional chiral supergravities suffer from gravitational, gauge and mixed anomalies which render the theories inconsistent at the quantum level. Consistency is restored if the anomalies of the theory cancel via the Green-Schwarz mechanism or generalizations thereof. The anomaly cancellation conditions translate into a certain set of constraints for the gauge group of the theory as well as on its matter content. For the case of ungauged theories these constraints admit numerous solutions but, in the case of gauged theories, the allowed solutions are remarkably few. In this thesis, we examine these anomaly cancellation conditions in detail and we present all solutions to these conditions under certain restrictions on the allowed gauge groups and representations, imposed for practical reasons. We also briefly examine anomaly cancellation in the context of Horava-Witt...

  2. Network anomaly detection a machine learning perspective

    CERN Document Server

    Bhattacharyya, Dhruba Kumar

    2013-01-01

    With the rapid rise in the ubiquity and sophistication of Internet technology and the accompanying growth in the number of network attacks, network intrusion detection has become increasingly important. Anomaly-based network intrusion detection refers to finding exceptional or nonconforming patterns in network traffic data compared to normal behavior. Finding these anomalies has extensive applications in areas such as cyber security, credit card and insurance fraud detection, and military surveillance for enemy activities. Network Anomaly Detection: A Machine Learning Perspective presents mach

  3. Acardiac anceps: a rare congenital anomaly

    Science.gov (United States)

    Nigam, Aruna; Agarwal, Rohini; Saxena, Pikee; Barla, Jaya

    2014-01-01

    Acardiac twin is a rare congenital anomaly and is exclusively associated with monochorionic twin pregnancies. The abnormalities occur due to abnormal communication between the two fetuses in the form of arterioarterial and venovenous communications, resulting in a grossly abnormal acardiac twin with reduction anomalies mainly of the upper body and gross oedema. Since no two acardiac twins are alike, this case report will add to the acardiac twin anomaly spectrum. PMID:24717594

  4. Acardiac anceps: a rare congenital anomaly

    OpenAIRE

    Nigam, Aruna; Agarwal, Rohini; Saxena, Pikee; Barla, Jaya

    2014-01-01

    Acardiac twin is a rare congenital anomaly and is exclusively associated with monochorionic twin pregnancies. The abnormalities occur due to abnormal communication between the two fetuses in the form of arterioarterial and venovenous communications, resulting in a grossly abnormal acardiac twin with reduction anomalies mainly of the upper body and gross oedema. Since no two acardiac twins are alike, this case report will add to the acardiac twin anomaly spectrum.

  5. Minor congenital anomalies and ataxic cerebral palsy.

    OpenAIRE

    Miller, G

    1989-01-01

    The incidence of minor congenital anomalies was examined in 36 patients with ataxic cerebral palsy, in unaffected family members, and in 100 unrelated control subjects. None of the control subjects or family members had more than four anomalies, and 25 of 36 (69%) of the patients had more than four. The distribution of anomalies differed considerably, with 60% of the index cases having seven or more, and 94% of the controls having three or less. The number occurring in the patients was signif...

  6. On Newton-Cartan trace anomalies

    CERN Document Server

    Auzzi, Roberto; Nardelli, Giuseppe

    2015-01-01

    We classify the trace anomaly for parity-invariant non-relativistic Schr\\"odinger theories in 2+1 dimensions coupled to background Newton-Cartan gravity. The general anomaly structure looks very different from the one in the z=2 Lifshitz theories. The type A content of the anomaly is remarkably identical to that of the relativistic 3+1 dimensional case, suggesting the conjecture that an a-theorem should exist also in the Newton-Cartan context.

  7. Development and Congenital Anomalies of the Pancreas

    OpenAIRE

    Bunsei Nobukawa; Hiroyuki Tadokoro; Masaru Takase

    2011-01-01

    Understanding how the pancreas develops is essential to understand the pathogenesis of congenital pancreatic anomalies. Recent studies have shown the advantages of investigating the development of frogs, mice, and chickens for understanding early embryonic development of the pancreas and congenital anomalies, such as choledochal cysts, anomalous pancreaticobiliary junction, annular pancreas, and pancreas divisum. These anomalies arise from failure of complete rotation and fusion during embryo...

  8. Quantum anomalies and some recent developments

    CERN Document Server

    Fujikawa, Kazuo

    2009-01-01

    Some of the developments related to quantum anomalies and path integrals during the past 10 years are briefly discussed. The covered subjects include the issues related to the local counter term in the context of 2-dimensional path integral bosonization and the treatment of chiral anomaly and index theorem on the lattice. We also briefly comment on a recent analysis of the connection between the two-dimensional chiral anomalies and the four-dimensional black hole radiation.

  9. A Survey on Social Media Anomaly Detection

    OpenAIRE

    Yu, Rose; Qiu, Huida; Wen, Zhen; Lin, Ching-Yung; Liu, Yan

    2016-01-01

    Social media anomaly detection is of critical importance to prevent malicious activities such as bullying, terrorist attack planning, and fraud information dissemination. With the recent popularity of social media, new types of anomalous behaviors arise, causing concerns from various parties. While a large amount of work have been dedicated to traditional anomaly detection problems, we observe a surge of research interests in the new realm of social media anomaly detection. In this paper, we ...

  10. Anomaly-induced charges in baryons

    OpenAIRE

    Eto, Minoru; Hashimoto, Koji; Iida, Hideaki; Ishii, Takaaki; Maezawa, Yu

    2011-01-01

    We show that quantum chiral anomaly of QCD in magnetic backgrounds induces a novel structure of electric charge inside baryons. To illustrate the anomaly effect, we employ the Skyrme model for baryons, with the anomaly-induced gauged Wess-Zumino term (\\pi_0 + (multi-pion)) E_i B_i. Due to this term, the Skyrmions giving a local pion condensation ((\\pi_0 + (multi-pion)) \

  11. On the hyperfine anomaly in Eu isotopes

    OpenAIRE

    Persson, J. R.

    2009-01-01

    A new method for determining the hyperfine anomaly, without knowing the nuclear magnetic moment, is used for the first time on a series of unstable isotopes. The relative large number of experimental data in Eu makes it possible to determine the hyperfine anomaly for a number of unstable isotopes. Calculations of the Bohr-Weisskopf effect and hence the hyperfine anomaly has been performed using the particle-rotor formalism. The result from the calculations and experiments is compared with oth...

  12. EVIDENCE OF ACCRUALS ANOMALY AROUND THE GLOBE

    OpenAIRE

    Diana Muresan

    2014-01-01

    This paper reviews the empirical researchon accruals anomaly around theglobe.Accruals anomaly is defined as the negative relation between accruals and future stock returns.Starting with Sloan (1996) many papers have documented and confirmed the existence of accrualsanomaly in US capital market. Though, recent papers started to examine the existence of accrualsanomaly outside the US.Overall, empirical results suggest that accruals anomaly is a globalphenomenonpresent in developed countries wit...

  13. Conscious and unconscious detection of semantic anomalies.

    Science.gov (United States)

    Hannon, Brenda

    2015-01-01

    When asked What superhero is associated with bats, Robin, the Penguin, Metropolis, Catwoman, the Riddler, the Joker, and Mr. Freeze? people frequently fail to notice the anomalous word Metropolis. The goals of this study were to determine whether detection of semantic anomalies, like Metropolis, is conscious or unconscious and whether this detection is immediate or delayed. To achieve these goals, participants answered anomalous and nonanomalous questions as their reading times for words were recorded. Comparisons between detected versus undetected anomalies revealed slower reading times for detected anomalies-a finding that suggests that people immediately and consciously detected anomalies. Further, comparisons between first and second words following undetected anomalies versus nonanomalous controls revealed some slower reading times for first and second words-a finding that suggests that people may have unconsciously detected anomalies but this detection was delayed. Taken together, these findings support the idea that when we are immediately aware of a semantic anomaly (i.e., immediate conscious detection) our language processes make immediate adjustments in order to reconcile contradictory information of anomalies with surrounding text; however, even when we are not consciously aware of semantic anomalies, our language processes still make these adjustments, although these adjustments are delayed (i.e., delayed unconscious detection). PMID:25624136

  14. Associativity Anomaly in String Field Theory

    OpenAIRE

    Bars, Itzhak; Matsuo, Yutaka

    2002-01-01

    We give a detailed study of the associativity anomaly in open string field theory from the viewpoint of the split string and Moyal formalisms. The origin of the anomaly is reduced to the properties of the special infinite size matrices which relate the conventional open string to the split string variables, and is intimately related to midpoint issues. We discuss two steps to cope with the anomaly. We identify the field subspace that causes the anomaly which is related to the existence of clo...

  15. MRI of central nervous system anomalies

    International Nuclear Information System (INIS)

    MRI was very useful in the evaluation of congenital anomalies of central nervous system as well as other nervous system disease with three-dimensional spatial resolution. We had experienced MRI of central nervous system anomalies, demonstrated characterisitic findings in each anomaly. MRI is useful to observe the coronal, horizontal and sagittal images of the brain and spinal cord in order to discuss the etiological mechanisms of spinal dysraphysm and its associated anomalies. In case of spina bifida cystica MRI was available to decide operative indication for radical operation and tetherd cord developed from postoperative scar or accompanied intraspinal lesions. (author)

  16. MRI of central nervous system anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Izawa, M.; Oikawa, A.; Matoba, A.

    1987-05-01

    MRI was very useful in the evaluation of congenital anomalies of central nervous system as well as other nervous system disease with three-dimensional spatial resolution. We had experienced MRI of central nervous system anomalies, demonstrated characterisitic findings in each anomaly. MRI is useful to observe the coronal, horizontal and sagittal images of the brain and spinal cord in order to discuss the etiological mechanisms of spinal dysraphysm and its associated anomalies. In case of spina bifida cystica MRI was available to decide operative indication for radical operation and tetherd cord developed from postoperative scar or accompanied intraspinal lesions.

  17. Anomaly-Free Sets of Fermions

    CERN Document Server

    Batra, P; Spivak, D; Batra, Puneet; Dobrescu, Bogdan A.; Spivak, David

    2006-01-01

    We present new techniques for finding anomaly-free sets of fermions. Although the anomaly cancellation conditions typically include cubic equations with integer variables that cannot be solved in general, we prove by construction that any chiral set of fermions can be embedded in a larger set of fermions which is chiral and anomaly-free. Applying these techniques to extensions of the Standard Model, we find anomaly-free models that have arbitrary quark and lepton charges under an additional U(1) gauge group.

  18. Galilean anomalies and their effect on hydrodynamics

    Science.gov (United States)

    Jain, Akash

    2016-03-01

    We study flavor and gravitational anomalies in Galilean theories coupled to torsional Newton-Cartan backgrounds. We establish that the relativistic anomaly inflow mechanism with an appropriately modified anomaly polynomial can be used to generate these anomalies. Similar to the relativistic case, we find that Galilean anomalies also survive only in even dimensions. Further, these anomalies only effect the flavor and rotational symmetries of a Galilean theory; in particular, the Milne boost symmetry remains nonanomalous. We also extend the transgression machinery used in relativistic fluids to Galilean fluids, and use it to determine how these anomalies affect the constitutive relations of a Galilean fluid. Unrelated to the Galilean fluids, we propose an analogue of the off-shell second law of thermodynamics for relativistic fluids, to include torsion and a conserved spin current in the vielbein formalism. Interestingly, we find that even in the absence of spin current and torsion the entropy currents in the two formalisms are different: while the usual entropy current gets a contribution from the gravitational anomaly, the entropy current in the vielbein formalism does not have any anomaly-induced part.

  19. Anomaly-free sets of fermions

    Energy Technology Data Exchange (ETDEWEB)

    Batra, Puneet; /Argonne; Dobrescu, Bogdan A.; /Fermilab; Spivak, David; /UC, Berkeley, Math. Dept.

    2005-10-01

    We present new techniques for finding anomaly-free sets of fermions. Although the anomaly cancellation conditions typically include cubic equations with integer variables that cannot be solved in general, we prove by construction that any chiral set of fermions can be embedded in a larger set of fermions which is chiral and anomaly-free. Applying these techniques to extensions of the Standard Model, we find anomaly-free models that have arbitrary quark and lepton charges under an additional U(1) gauge group.

  20. Initial scalar magnetic anomaly map from Magsat

    Science.gov (United States)

    Langel, R. A.; Phillips, J. D.; Horner, R. J.

    1982-01-01

    Magsat data acquired during the November 1979-June 1980 mission was used to derive a scalar magnetic anomaly map covering +50 to -50 deg geographic latitude, and the separation of anomaly fields from core and external fields was accomplished by techniques developed for POGO satellite data. Except in the Atlantic and Pacific at latitudes south of -15 deg, comparison of the Magsat map with its POGO data-derived counterpart shows basic anomaly patterns to be reproducible, and higher resolution due to Magsat's lower measurement altitude. Color-coded scalar anomaly maps are presented for both satellites.

  1. Satellite Magnetic Anomalies of Africa and Europe

    Science.gov (United States)

    Hinze, W. J.; Vonfrese, R. R. B. (Principal Investigator); Olivier, R.

    1984-01-01

    Preliminary MAGSAT scalar magnetic anomaly data of Africa, Europe, and adjacent marine areas were reduced to the pole assuming a constant inducing Earth's magnetic field of 60,000 nT. This process leads to a consistent anomaly data set free from marked variations in directional and intensity effects of the Earth's magnetic field over this extensive region. The resulting data are correlated with long wave length-pass filtered free-air gravity anomalies; regional heat flow, and tectonic data to investigate magatectonic elements and the region's geologic history. Magnetic anomalies are related to both ancient as well as more recent Cenozoic structural features.

  2. The "Parity" Anomaly On An Unorientable Manifold

    CERN Document Server

    Witten, Edward

    2016-01-01

    The "parity" anomaly -- more accurately described as an anomaly in time-reversal or reflection symmetry -- arises in certain theories of fermions coupled to gauge fields and/or gravity in a spacetime of odd dimension. The "parity" anomaly has traditionally been studied on orientable manifolds only, but recent developments involving topological superconductors have made it clear that one can get more information by asking what happens on an unorientable manifold. In this paper, we analyze the "parity" anomaly for fermions coupled to gauge fields and gravity in $2+1$ dimensions. We consider applications to gapped boundary states of a topological superconductor and to M2-branes in string/M-theory.

  3. Pediatric cardiac postoperative care

    Directory of Open Access Journals (Sweden)

    Auler Jr. José Otávio Costa

    2002-01-01

    Full Text Available The Heart Institute of the University of São Paulo, Medical School is a referral center for the treatment of congenital heart diseases of neonates and infants. In the recent years, the excellent surgical results obtained in our institution may be in part due to modern anesthetic care and to postoperative care based on well-structured protocols. The purpose of this article is to review unique aspects of neonate cardiovascular physiology, the impact of extracorporeal circulation on postoperative evolution, and the prescription for pharmacological support of acute cardiac dysfunction based on our cardiac unit protocols. The main causes of low cardiac output after surgical correction of heart congenital disease are reviewed, and methods of treatment and support are proposed as derived from the relevant literature and our protocols.

  4. Diagnostic Importance of 3D CT Images in Klippel-Feil Syndrome with Multiple Skeletal Anomalies: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Yuksel, Murvet [Kahramanmaras Sutcu Imam University, Radiology Dept. (Turkey); Karabiber, Hamza [Kahramanmaras Sutcu Imam University Pediatrics Dept. (Turkey); Yuksel, K. Zafer [Kahramanmaras Sutcu Imam University Neuroradiology Dept (Turkey); Parmaksiz, Gonul [Kahramanmaras Sutcu Imam University Pediatrics Dept. (Turkey)

    2005-07-01

    We present here the case of a 12-year-old boy who had Klippel-Feil syndrome with renal, cardiac and multiple skeletal anomalies, and we show the relevent three-dimensional computed tomography images. Our patient had a triple renal pelvis, mitral valve prolapsus, multiple cervical vertebrae fusions, cervical ribs, hypoplasia of the right thumb, spina bifida of L5, lumbalization at the right side of S1 and a sacral curved defect. In this study, we discuss the atypical clinical features and the diagnostic value of three-dimensional CT for evaluating the skeletal anomalies of the Klippel-Feil syndrome cases.

  5. Diagnostic Importance of 3D CT Images in Klippel-Feil Syndrome with Multiple Skeletal Anomalies: A Case Report

    International Nuclear Information System (INIS)

    We present here the case of a 12-year-old boy who had Klippel-Feil syndrome with renal, cardiac and multiple skeletal anomalies, and we show the relevent three-dimensional computed tomography images. Our patient had a triple renal pelvis, mitral valve prolapsus, multiple cervical vertebrae fusions, cervical ribs, hypoplasia of the right thumb, spina bifida of L5, lumbalization at the right side of S1 and a sacral curved defect. In this study, we discuss the atypical clinical features and the diagnostic value of three-dimensional CT for evaluating the skeletal anomalies of the Klippel-Feil syndrome cases

  6. Right-sided superior vena cava draining into the left atrium: a rare anomaly of systemic venous return

    Energy Technology Data Exchange (ETDEWEB)

    Aminololama-Shakeri, Shadi; Wootton-Gorges, Sandra L.; Reyes, Melissa; Moore, Elizabeth H. [University of California Davis, Medical Center and Children' s Hospital, Department of Radiology, Sacramento, CA (United States); Pretzlaff, Robert K. [University of California Davis, Medical Center and Children' s Hospital, Department of Pediatrics, Sacramento, CA (United States)

    2007-03-15

    The most commonly encountered systemic thoracic venous anomaly is a persistent left superior vena cava that drains into the right atrium via the coronary sinus. A much rarer systemic venous anomaly is that of isolated anomalous drainage of a normally positioned right superior vena cava (RSVC) into the left atrium (LA). This has been reported in approximately 20 patients with the diagnosis usually being made by cardiac catheterization. We report the case of a toddler with asymptomatic hypoxemia resulting from anomalous drainage of a normal RSVC into his LA. This was diagnosed non-invasively by contrast-enhanced chest CT. (orig.)

  7. Giant Cardiac Cavernous Hemangioma.

    Science.gov (United States)

    Unger, Eric; Costic, Joseph; Laub, Glenn

    2015-07-01

    We report the case of an asymptomatic giant cardiac cavernous hemangioma in a 71-year-old man. The intracardiac mass was discovered incidentally during surveillance for his prostate cancer; however, the patient initially declined intervention. On presentation to our institution 7 years later, the lesion had enlarged significantly, and the patient consented to excision. At surgery, an 8 × 6.5 × 4.8 cm intracardiac mass located on the inferior heart border was excised with an intact capsule through a median sternotomy approach. The patient had an uneventful postoperative course. We discuss the diagnostic workup, treatment, and characteristics of this rare cardiac tumor. PMID:26140782

  8. Radiography in cardiology [cardiac disorders, cardiac insufficiency

    International Nuclear Information System (INIS)

    The diagnostic procedure in cardiology nearly always requires an X-ray examination of the thorax. This examination is very informative when it is correctly performed and interpreted. The radiographs need to be read precisely and comprehensively: this includes the evaluation of the silhouette of the heart (size, form and position) as well as the examination of extra-cardiac thoracic structures allowing among other things to search for signs of cardiac insufficiency. The conclusion of the X-ray examination can be drawn after having brought together information concerning the case history, the clinical examination and the study of the radiographs. The radiologist finds himself in one of three situations: (1) the information provided by the X-ray pictures is characteristic of a disease and permits a diagnosis, (2) the X-ray pictures indicate a group of hypotheses; further complementary tests could be useful and (3) the X-ray pictures provide ambiguous even contradictory information; it is necessary to complete the radiological examination by other techniques such as an ultrasonographic study of the heart

  9. Serum myoglobin after cardiac catheterisation.

    OpenAIRE

    McComb, J. M.; McMaster, E A

    1982-01-01

    Study of 80 consecutive patients undergoing elective diagnostic cardiac catheterisation showed that after the procedure 25 (31%) developed myoglobinaemia. This was attributed to complications of the catheterisation in two. The remaining 23 had received premedication by intramuscular injection. In patients without intramuscular injections myoglobinaemia did not occur after uncomplicated cardiac catheterisation. The study did not support the proposition that cardiac catheterisation results in m...

  10. Hepato-cardiac disorders

    Institute of Scientific and Technical Information of China (English)

    Yasser; Mahrous; Fouad; Reem; Yehia

    2014-01-01

    Understanding the mutual relationship between the liver and the heart is important for both hepatologists and cardiologists. Hepato-cardiac diseases can be classified into heart diseases affecting the liver, liver diseases affecting the heart, and conditions affecting the heart and the liver at the same time. Differential diagnoses of liver injury are extremely important in a cardiologist’s clinical practice calling for collaboration between cardiologists and hepatologists due to the many other diseases that can affect the liver and mimic haemodynamic injury. Acute and chronic heart failure may lead to acute ischemic hepatitis or chronic congestive hepatopathy. Treatment in these cases should be directed to the primary heart disease. In patients with advanced liver disease, cirrhotic cardiomyopathy may develop including hemodynamic changes, diastolic and systolic dysfunctions, reduced cardiac performance and electrophysiological abnormalities. Cardiac evaluation is important for patients with liver diseases especially before and after liver transplantation. Liver transplantation may lead to the improvement of all cardiac changes and the reversal of cirrhotic cardiomyopathy. There are systemic diseases that may affect both the liver and the heart concomitantly including congenital, metabolic and inflammatory diseases as well as alcoholism. This review highlights these hepatocardiac diseases

  11. Primary cardiac tumors

    International Nuclear Information System (INIS)

    Cardiac tumors happen to be among the less known pathologies without clear treatment standards. Even one decade ago most of the cardiac tumor diagnosis were made post mortem, and only reports of isolated cases could be found in the literature, showing the lack of interest in the investigation of these pathologies by cardiology and cardiovascular surgery specialists. With the development of echocardiography and of cardiovascular surgery, more cases of primary and metastatic cardiac tumors have been diagnosed. Many cases have been treated by palliative or curative surgical interventions, thus increasing the reports in the world literature and the experience in this field, and pointing out the real incidence of these pathologies, not being as bizarre as it had been considered. a revision of the literature will be made, in which the frequency and the suggested interventions will be reported, as well as the cases of cardiac pathology in two cardiovascular centers of the country known by the author. The echocardiographic, pathologic and histological characteristics of the representative cases will be presented, without a greater evidence level, due to the problem's incidence and the few cases reported by these centers

  12. Cardiac MRI tagging

    International Nuclear Information System (INIS)

    Cardiac MRI tagging is an original technique based upon the perturbation of the magnetization of determined regions of the myocardium (tags). The motion of the tags accurately reflects the deformation of the underlying tissue. Data analysis requires special techniques to reconstruct the 3D motion of the heart, and to evaluate the myocardial strain, locally and throughout the whole heart. (authors)

  13. Automatic Implantable Cardiac Defibrillator

    Medline Plus

    Full Text Available ... Over the next hour you'll see the implantation of an automated implantable cardiac defibrillator. The surgery ... evening we're going to be discussing the implantation of a defibrillator. It’s a battery-powered implantable ...

  14. Cardiac effects of vasopressin.

    Science.gov (United States)

    Pelletier, Jean-Sébastien; Dicken, Bryan; Bigam, David; Cheung, Po-Yin

    2014-07-01

    Vasopressin is an essential hormone involved in the maintenance of cardiovascular homeostasis. It has been in use therapeutically for many decades, with an emphasis on its vasoconstrictive and antidiuretic properties. However, this hormone has a ubiquitous influence and has specific effects on the heart. Although difficult to separate from its powerful vascular effects in the clinical setting, a better understanding of vasopressin's direct cardiac effects could lead to its more effective clinical use for a variety of shock states by maximizing its therapeutic benefit. The cardiac-specific effects of vasopressin are complex and require further elucidation. Complicating our understanding include the various receptors and secondary messengers involved in vasopressin's effects, which may lead to various results based on differing doses and varying environmental conditions. Thus, there have been contradictory reports on vasopressin's action on the coronary vasculature and on its effect on inotropy. However, beneficial results have been found and warrant further study to expand the potential therapeutic role of vasopressin. This review outlines the effect of vasopressin on the coronary vasculature, cardiac contractility, and on hypertrophy and cardioprotection. These cardiac-specific effects of vasopressin represent an interesting area for further study for potentially important therapeutic benefits. PMID:24621650

  15. Cardiac pacemaker power sources

    International Nuclear Information System (INIS)

    A review of chemical and radioisotope batteries used in cardiac pacemakers is presented. The battery systems are examined in terms of longevity, reliability, cost, size and shape, energy density, weight, internal resistance versus time, end-of-life voltage, chemical compatibility, and potential failure mechanisms

  16. Limb anomalies in the CHARGE association.

    OpenAIRE

    Meinecke, P.; Polke, A; Schmiegelow, P

    1989-01-01

    We report a male infant with iris coloboma, choanal atresia, postnatal retardation of growth and psychomotor development, genital anomaly, ear anomaly, and anal atresia. In addition, there was cutaneous syndactyly and nail hypoplasia of the second and third fingers on the right and hypoplasia of the left second finger nail. Comparable observations have rarely been reported and possibly represent genetic heterogeneity.

  17. Effective action for supersymmetrical chiral anomaly

    International Nuclear Information System (INIS)

    It is proved that the consistency conditions of the type of Wess-Zumino conditions are necessary and sufficient for local integrability of supersymmetrical chiral anomaly. The global integrability condition implies discreteness of the coefficient in anomalous action. Explicit formulas for consistent anomalies and corresponding functional depending on superfields of various types are obtained

  18. Photodiode and photomultiplier areal sensitivity anomalies

    Science.gov (United States)

    Youngbluth, O., Jr.

    1977-01-01

    Several silicon photodiodes and photomultipliers were tested to determine signal variations as a light spot was scanned over the photosensitive surface of these detectors. Qualitative and quantitative data is presented to demonstrate the areal sensitivity anomalies. These anomalies are related back to the fabrication techniques of the manufacturers.

  19. Improved prenatal detection of chromosomal anomalies

    DEFF Research Database (Denmark)

    Frøslev-Friis, Christina; Hjort-Pedersen, Karina; Henriques, Carsten U;

    2011-01-01

    Prenatal screening for karyotype anomalies takes place in most European countries. In Denmark, the screening method was changed in 2005. The aim of this study was to study the trends in prevalence and prenatal detection rates of chromosome anomalies and Down syndrome (DS) over a 22-year period....

  20. Remarks on Global Anomalies in RCFT Orientifolds

    CERN Document Server

    Gato-Rivera, Beatriz

    2006-01-01

    We check the list of supersymmetric standard model orientifold spectra of Dijkstra, Huiszoon and Schellekens for the presence of global anomalies, using probe branes. Absence of global anomalies is found to impose strong constraints, but in nearly all cases they are automatically satisfied by the solutions to the tadpole cancellation conditions.

  1. Remarks on global anomalies in RCFT orientifolds

    Energy Technology Data Exchange (ETDEWEB)

    Gato-Rivera, B. [NIKHEF Theory Group, Kruislaan 409, 1098 SJ Amsterdam (Netherlands); Instituto de Matematicas y Fisica Fundamental, CSIC, Serrano 123, Madrid 28006 (Spain); Schellekens, A.N. [NIKHEF Theory Group, Kruislaan 409, 1098 SJ Amsterdam (Netherlands) and Instituto de Matematicas y Fisica Fundamental, CSIC, Serrano 123, Madrid 28006 (Spain) and IMAPP, Radboud Universiteit, Nijmegen (Netherlands)]. E-mail: t58@nikhef.nl

    2006-01-26

    We check the list of supersymmetric standard model orientifold spectra of Dijkstra, Huiszoon and Schellekens for the presence of global anomalies, using probe branes. Absence of global anomalies is found to impose strong constraints, but in nearly all cases they are automatically satisfied by the solutions to the tadpole cancellation conditions.

  2. Indicated preterm birth for fetal anomalies.

    Science.gov (United States)

    Craigo, Sabrina D

    2011-10-01

    Between 2% and 3% of pregnancies are complicated by fetal anomalies. For most anomalies, there is no advantage to late preterm or early-term delivery. The risks of maternal or fetal complication are specific for each anomaly. Very few anomalies pose potential maternal risk. Some anomalies carry ongoing risks to the fetus, such as an increased risk of fetal death, hemorrhage, or organ damage. In a limited number of select cases, the advantages of late preterm or early-term birth may include avoiding an ongoing risk of fetal death related to the anomaly, allowing delivery in a controlled setting with availability of subspecialists and allowing direct care for the neonate with organ injury. The optimal gestational age for delivery cannot be determined for all pregnancies complicated by fetal anomalies. For most pregnancies complicated by anomalies, there is no change to obstetrical management regarding timing of delivery. For those that may benefit from late preterm or early-term delivery, variability exists such that each management plan should be individualized. PMID:21962626

  3. Anomalies of Nuclear Criticality, Revision 6

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, E. D.; Prichard, Andrew W.; Durst, Bonita E.; Erickson, David; Puigh, Raymond J.

    2010-02-19

    This report is revision 6 of the Anomalies of Nuclear Criticality. This report is required reading for the training of criticality professionals in many organizations both nationally and internationally. This report describes many different classes of nuclear criticality anomalies that are different than expected.

  4. Chiral Anomaly in Toroidal Carbon Nanotubes

    OpenAIRE

    Sasaki, K.

    2001-01-01

    It is pointed out that the chiral anomaly in 1+1 dimensions should be observed in toroidal carbon nanotubes on a planar geometry with varying magnetic field. We show that the chiral anomaly is closely connected with the persistent current in a one-dimensional metallic ring.

  5. Trends in hemispheric warm and cold anomalies

    Science.gov (United States)

    Robeson, Scott M.; Willmott, Cort J.; Jones, Phil D.

    2014-12-01

    Using a spatial percentile approach, we explore the magnitude of temperature anomalies across the Northern and Southern Hemispheres. Linear trends in spatial percentile series are estimated for 1881-2013, the most recent 30 year period (1984-2013), and 1998-2013. All spatial percentiles in both hemispheres show increases from 1881 to 2013, but warming occurred unevenly via modification of cold anomalies, producing a reduction in spatial dispersion. In the most recent 30 year period, trends also were consistently positive, with warm anomalies having much larger warming rates than those of cold anomalies in both hemispheres. This recent trend has largely reversed the decrease in spatial dispersion that occurred during the twentieth century. While the period associated with the recent slowdown of global warming, 1998-2013, is too brief to estimate trends reliably, cooling was evident in NH warm and cold anomalies during January and February while other months in the NH continued to warm.

  6. Congenital anomalies of the spine: radiologic findings

    International Nuclear Information System (INIS)

    Congenital anomalies of the spine are frequent and variable. Some are restricted to skeletal structures, while others involve combine neural tube defects or are associated with other multi-systemic disorders. Structural spinal anomalies can be classified according to their location: 1) the vertebral body, 2) the articular process, 3) the lamina with spinous process, 4) the pars interarticularis, 5) the facet joint, 6) the pedicle, or 7) other. Because of similarities between these congenital anomalies and (a) secondary changes involving infection or joint disease and (b) deformities resulting from trauma and uncertain tumorous conditions, significant confusion can occur during diagnosis. Moreover, since the anomalies often give rise to both functional impairment and cosmetic problem, appropriate treatment relies crucially on accurate diagnosis. The authors illustrate the pathogenesis and radiologic findings of the relatively common spinal anomalies confined to skeletal structures

  7. Seasonality of congenital anomalies in Europe

    DEFF Research Database (Denmark)

    Luteijn, Johannes Michiel; Dolk, Helen; Addor, Marie-Claude;

    2014-01-01

    with influenza. RESULTS: We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12......%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. CONCLUSION: We have confirmed previously described seasonality for congenital cataract and hip...... dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor...

  8. Regional magnetic anomaly constraints on continental rifting

    Science.gov (United States)

    Vonfrese, R. R. B.; Hinze, W. J.; Olivier, R.; Bentley, C. R.

    1985-01-01

    Radially polarized MAGSAT anomalies of North and South America, Europe, Africa, India, Australia and Antarctica demonstrate remarkably detailed correlation of regional magnetic lithospheric sources across rifted margins when plotted on a reconstruction of Pangea. These major magnetic features apparently preserve their integrity until a superimposed metamorphoric event alters the magnitude and pattern of the anomalies. The longevity of continental scale magnetic anomalies contrasts markedly with that of regional gravity anomalies which tend to reflect predominantly isostatic adjustments associated with neo-tectonism. First observed as a result of NASA's magnetic satellite programs, these anomalies provide new and fundamental constraints on the geologic evolution and dynamics of the continents and oceans. Accordingly, satellite magnetic observations provide a further tool for investigating continental drift to compliment other lines of evidence in paleoclimatology, paleontology, paleomagnetism, and studies of the radiometric ages and geometric fit of the continents.

  9. Global magnetic anomaly and aurora of Neptune

    Science.gov (United States)

    Cheng, Andrew F.

    1990-01-01

    The large offset and tilt of Neptune's dipole magnetic field combine to create a global magnetic anomaly, analogous to but much more important than earth's South Atlantic Anomaly. Energetic particle precipitation loss within the Neptune anomaly creates 'atmospheric drift shadows' within which particle fluxes are greatly reduced. The energetic particle dropout observed by Voyager near closest approach occurred near the predicted times when Voyager passed within the atmospheric drift shadow. Extremely soft, structured bursts of ions and electrons within the drift shadow may result from plasma wave-induced pitch angle scattering of trapped particles confined near the magnetic equator. The dropout does not necessarily imply that Voyager passed through an earth-like discrete auroral zone, as earlier reported. The ion and electron fluxes observed within the dropout period correspond to particles that must precipitate to Neptune's atmosphere within the anomaly region. This anomaly precipitation can account for a major portion of the ultraviolet emissions previously identified as Neptune aurora.

  10. [Cardiac amyloidosis. General review].

    Science.gov (United States)

    Laraki, R

    1994-04-01

    Cardiac amyloidosis, most often of AL type, is a non-exceptional disease as it represents 5 to 10% of non-ischemic cardiomyopathies. It realizes typically a restrictive cardiomyopathy. Nevertheless the wide diversity of possible presentation makes it a "big shammer" which must be evoked in front of every unexplained cardiopathy after the age of forty. If some associated manifestations can rapidly suggest the diagnosis, as a peripheric neuropathy especially a carpal tunnel syndrome or palpebral ecchymosis, cardiac involvement can also evolve in an apparently isolated way. The most suggestive paraclinic elements for the diagnosis are, in one hand, the increased myocardial echogenicity with a "granular sparkling" appearance seen throughout all walls of the left ventricle and, in the other hand, the association of a thickened left ventricle and a low voltage (electrocardiogram could also show pseudo-infarct Q waves). In front of such aspects, the proof of amyloidosis is brought by an extra-cardiac biopsy or by scintigraphy with labelled serum amyloid P component, so that the indications of endomyocardial biopsy are very limited today. The identification of the amyloid nature of a cardiopathy has an direct therapeutic implication: it contra-indicates the use of digitalis, calcium channel blockers and beta-blockers. The treatment of AL amyloidosis (chemotherapy with alkylant agents) remains very unsatisfactory especially in the cardiac involvement which is the most frequent cause of death (in AL amyloidosis). Last, cardiac amyloidosis is a bad indication for transplantation which results are burden by rapid progression of deposits especially in the gastro-intestinal tract and the nervous system. PMID:8059146

  11. Cardiac surgery outcomes.

    Science.gov (United States)

    Halpin, Linda S; Barnett, Scott D; Beachy, Jim

    2003-01-01

    Accrediting organizations and payers are demanding valid and reliable data that demonstrate the value of services. Federal agencies, healthcare industry groups, and healthcare watchdog groups are increasing the demand for public access to outcomes data. A new and growing outcomes dynamic is the information requested by prospective patients in an increasingly consumer-oriented business. Patients demand outcomes, and resources are developing to meet these demands. Physicians are increasingly confronted with requests for information about their mortality and morbidity rates, malpractice suits, and disciplinary actions received. For example, in Virginia, prospective patients have access to data provided by the nonprofit group Virginia Health Information. After numerous resolutions by the Virginia Senate since 1999, the prospective Virginia medical consumer now has access to several annual publications: Virginia Hospitals: A Consumer's Guide, 1999 Annual Report and Strategic Plan Update, and the 1999 Industry Report: Virginia Hospitals and Nursing Facilities. Consumers have access to cardiac outcomes data stratified by hospital, gender, and cardiac service line (cardiac surgery, noninvasive cardiology, and invasive cardiology). This is particularly relevant to IHI because Virginia Health Information specifically targets cardiac care. IHI has a sizable investment in cardiovascular outcomes and has found outcomes measurement and research are key to providing quality care. IHI's goal is to move from an outcomes management model to a disease management model. The hope is to incorporate all aspects of the patient's continuum of care, from preoperative and diagnostic services through cardiac interventions to postoperative rehabilitation. Furthermore, every step along the way will be supported with functional status and quality of life assessments. Although these goals are ambitious and expensive, the return on investment is high. PMID:14618772

  12. Sea surface temperature anomalies in the Arabian Sea

    Digital Repository Service at National Institute of Oceanography (India)

    RameshKumar, M.R.

    temperature anomalies for the above regions respectively. An analysis has shown that most of the short duration anomalies (i.e., anomalies with periods less than 4 months) are driven by the surface heat fluxes. The medium duration anomalies (i.e., anomalies...

  13. Risk factors and the effect of cardiac resynchronization therapy on cardiac and non-cardiac mortality in MADIT-CRT

    DEFF Research Database (Denmark)

    Perkiomaki, Juha S; Ruwald, Anne-Christine; Kutyifa, Valentina;

    2015-01-01

    causes, 108 (63.9%) deemed cardiac, and 61 (36.1%) non-cardiac. In multivariate analysis, increased baseline creatinine was significantly associated with both cardiac and non-cardiac deaths [hazard ratio (HR) 2.97, P ...AIMS: To understand modes of death and factors associated with the risk for cardiac and non-cardiac deaths in patients with cardiac resynchronization therapy with implantable cardioverter-defibrillator (CRT-D) vs. implantable cardioverter-defibrillator (ICD) therapy, which may help clarify...

  14. Anomaly Detection in Dynamic Networks

    Energy Technology Data Exchange (ETDEWEB)

    Turcotte, Melissa [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-10-14

    Anomaly detection in dynamic communication networks has many important security applications. These networks can be extremely large and so detecting any changes in their structure can be computationally challenging; hence, computationally fast, parallelisable methods for monitoring the network are paramount. For this reason the methods presented here use independent node and edge based models to detect locally anomalous substructures within communication networks. As a first stage, the aim is to detect changes in the data streams arising from node or edge communications. Throughout the thesis simple, conjugate Bayesian models for counting processes are used to model these data streams. A second stage of analysis can then be performed on a much reduced subset of the network comprising nodes and edges which have been identified as potentially anomalous in the first stage. The first method assumes communications in a network arise from an inhomogeneous Poisson process with piecewise constant intensity. Anomaly detection is then treated as a changepoint problem on the intensities. The changepoint model is extended to incorporate seasonal behavior inherent in communication networks. This seasonal behavior is also viewed as a changepoint problem acting on a piecewise constant Poisson process. In a static time frame, inference is made on this extended model via a Gibbs sampling strategy. In a sequential time frame, where the data arrive as a stream, a novel, fast Sequential Monte Carlo (SMC) algorithm is introduced to sample from the sequence of posterior distributions of the change points over time. A second method is considered for monitoring communications in a large scale computer network. The usage patterns in these types of networks are very bursty in nature and don’t fit a Poisson process model. For tractable inference, discrete time models are considered, where the data are aggregated into discrete time periods and probability models are fitted to the

  15. Tectonic interpretation of aeromagnetic anomalies of Turkey

    International Nuclear Information System (INIS)

    Complete text of publication follows. In this presentation, an interpretation of the aeromagnetic anomalies of Turkey will be discussed. Aeromagnetic data acquired by the General Directorate of Mineral Research and Exploration of Turkey (MTA) is used in this study. Sensitivity of these data are suitable for regional studies. The International Geomagnetic Reference Field (IGRF) correction and advanced geophysical data processing methods were applied, and then data were gridded with 5x5 km intervals. Initially, aeromagnetic anomalies were upward continued to be at 2, 3, 5 and 7 km heights (including flight altitude). This application suppressed near surface effects and revealed that the 3 km upward continued aeromagnetic anomaly map is the most convenient map to reflect the deep-seated structures in Anatolia. Then, Reduction to the Pole (RTP) method was applied to the 3 km upward continued anomalies. Hence, it was observed that polarities of the most anomalies were aligned along the North-South direction. It is thought that the remanent magnetization is not existent in the west and the centre of Anatolia, in contrast to the east where polarities of the most anomalies are different from the north-south direction by the presence of strong remanent magnetization. In order to delineate the boundaries of the causative structures, Analytical Signal (AS) method was applied on the aeromagnetic anomalies. A sinuous boundary in the south of Turkey is apparent in the AS map which can be evaluated as suture zone between the Anatolides and non-magnetic African/Arabian Plate. Several important anomalies became more visible after AS transformation in Anatolia. These are, from west to east, the Suluklu-Cihanbeyli-Goloren (SCGA), Konya (KA), Cappadocian Volcanic Complex (CVCA) and Van Lake (VLA) magnetic anomalies. The East Anatolian Contractional Province Anomalies (EACPA) are intensively gathered in the East Anatolia where intensive earthquake activities are also observed. Magnetic

  16. Cardiac fusion and complex congenital cardiac defects in thoracopagus twins: diagnostic value of cardiac CT

    Energy Technology Data Exchange (ETDEWEB)

    Goo, Hyun Woo [University of Ulsan College of Medicine, Asan Medical Center, Department of Radiology and Research Institute of Radiology, Seoul (Korea, Republic of); Park, Jeong-Jun [University of Ulsan College of Medicine, Asan Medical Center, Department of Pediatric Cardiac Surgery, Seoul (Korea, Republic of); Kim, Ellen Ai-Rhan [University of Ulsan College of Medicine, Asan Medical Center, Division of Neonatology, Department of Pediatrics, Seoul (Korea, Republic of); Won, Hye-Sung [University of Ulsan College of Medicine, Asan Medical Center, Department of Obstetrics and Gynecology, Seoul (Korea, Republic of)

    2014-09-15

    Most thoracopagus twins present with cardiac fusion and associated congenital cardiac defects, and assessment of this anatomy is of critical importance in determining patient care and outcome. Cardiac CT with electrocardiographic triggering provides an accurate and quick morphological assessment of both intracardiac and extracardiac structures in newborns, making it the best imaging modality to assess thoracopagus twins during the neonatal period. In this case report, we highlight the diagnostic value of cardiac CT in thoracopagus twins with an interatrial channel and complex congenital cardiac defects. (orig.)

  17. Data Mining for Anomaly Detection

    Science.gov (United States)

    Biswas, Gautam; Mack, Daniel; Mylaraswamy, Dinkar; Bharadwaj, Raj

    2013-01-01

    The Vehicle Integrated Prognostics Reasoner (VIPR) program describes methods for enhanced diagnostics as well as a prognostic extension to current state of art Aircraft Diagnostic and Maintenance System (ADMS). VIPR introduced a new anomaly detection function for discovering previously undetected and undocumented situations, where there are clear deviations from nominal behavior. Once a baseline (nominal model of operations) is established, the detection and analysis is split between on-aircraft outlier generation and off-aircraft expert analysis to characterize and classify events that may not have been anticipated by individual system providers. Offline expert analysis is supported by data curation and data mining algorithms that can be applied in the contexts of supervised learning methods and unsupervised learning. In this report, we discuss efficient methods to implement the Kolmogorov complexity measure using compression algorithms, and run a systematic empirical analysis to determine the best compression measure. Our experiments established that the combination of the DZIP compression algorithm and CiDM distance measure provides the best results for capturing relevant properties of time series data encountered in aircraft operations. This combination was used as the basis for developing an unsupervised learning algorithm to define "nominal" flight segments using historical flight segments.

  18. Holography and Conformal Anomaly Matching

    CERN Document Server

    Cabo-Bizet, Alejandro; Narain, K S

    2013-01-01

    We discuss various issues related to the understanding of the conformal anomaly matching in CFT from the dual holographic viewpoint. First, we act with a PBH diffeomorphism on a generic 5D RG flow geometry and show that the corresponding on-shell bulk action reproduces the Wess-Zumino term for the dilaton of broken conformal symmetry, with the expected coefficient aUV-aIR. Then we consider a specific 3D example of RG flow whose UV asymptotics is normalizable and admits a 6D lifting. We promote a modulus \\rho appearing in the geometry to a function of boundary coordinates. In a 6D description {\\rho} is the scale of an SU(2) instanton. We determine the smooth deformed background up to second order in the space-time derivatives of \\rho and find that the 3D on-shell action reproduces a boundary kinetic term for the massless field \\tau= log(\\rho) with the correct coefficient \\delta c=cUV-cIR. We further analyze the linearized fluctuations around the deformed background geometry and compute the one-point functions ...

  19. Collie Eye Anomaly in Switzerland.

    Science.gov (United States)

    Walser-Reinhardt, L; Hässig, M; Spiess, B

    2009-12-01

    In this retrospective study, the results of 3'527 eye examinations in 6 different breeds affected with Collie Eye Anomaly (CEA) over a period of 8 years (1999 - 2007) are described. CEA was divided into three main ophthalmoscopic features, a) choroidal hypoplasia (CRH), b) CRH and coloboma and c) coloboma alone. Of the 101 Smooth Collies 8.9 % showed signs of CRH, whereas 36.9 % of Rough Collies were affected with CRH, 2.8 % with CRH and coloboma and 0.38 % with coloboma alone. Choroidal hypoplasia was present in 13.1 %, CRH and coloboma in 1.8 % and coloboma alone in 0.2 % of the Shetland Sheepdogs. Only one Australian Shepherd dog had CRH, while 0.7 % of the Border Collies were affected with CRH. None of the Nova Scotia Duck Tolling Retrievers were affected with CEA. There were no statistically significant differences in the occurrence of CEA between males and females, nor was there any relation between coat colors. Significant differences could be shown between dogs younger or older than 8 weeks at first examination. CEA was more often diagnosed in dogs younger than 8 weeks within the Rough Collie and Shetland Sheepdog. PMID:19946851

  20. PRENATAL ULTRASOUND SCREENING TO DIAGNOSE CONGENITA L ANOMALIES AMONG ONE THOUSAND UNSELECTED WOMEN AND THEIR PREGNANCY OUTCOME

    Directory of Open Access Journals (Sweden)

    Jhuma

    2013-03-01

    Full Text Available ABSTRACT: OBJECTIVES: Purpose of our study was to determine the detection rate of congenital anomalies in second trimester by single prenatal ultrasound screening in an unselected population and to evaluate the subsequent pregnancy outcome and to compare the results with published series using standardized cri teria. SUBJECTS AND METHODS - One thousand pregnant women at 18-22 weeks’ gestation we re screened by prenatal ultrasound examination. We compared these sonographic reports wit h pregnancy outcomes established by postnatal echocardiography and ultrasound examinatio ns of neonates and autopsy for dead fetuses. Statistical analysis was performed on two u nits; malformed fetus and malformation itself. RESULTS - A total of 27 fetuses with 30 anomalies were iden tified by prenatal ultrasound. Prospectively 2 babies with 2 anomalies were found t o be normal. On postnatal examination 13 babies were found to have 14 anomalies which could not be detected by ultrasound. Thus the sensitivity of ultrasound in detecting congenital a nomalies and anomalous fetuses was 66.6% and 67.5% respectively. Highest detection rate was o bserved for CNS anomalies (88.8% but that of craniofacial and musculoskeletal anomalies was not very satisfactory (33% in each system. CONCLUSION -This study shows rate of detection of fetal anomal ies is satisfactory for most organ systems except cardiac, musculoskeletal a nd craniofacial malformations

  1. Hamiltonian Anomalies from Extended Field Theories

    Science.gov (United States)

    Monnier, Samuel

    2015-09-01

    We develop a proposal by Freed to see anomalous field theories as relative field theories, namely field theories taking value in a field theory in one dimension higher, the anomaly field theory. We show that when the anomaly field theory is extended down to codimension 2, familiar facts about Hamiltonian anomalies can be naturally recovered, such as the fact that the anomalous symmetry group admits only a projective representation on the Hilbert space, or that the latter is really an abelian bundle gerbe over the moduli space. We include in the discussion the case of non-invertible anomaly field theories, which is relevant to six-dimensional (2, 0) superconformal theories. In this case, we show that the Hamiltonian anomaly is characterized by a degree 2 non-abelian group cohomology class, associated to the non-abelian gerbe playing the role of the state space of the anomalous theory. We construct Dai-Freed theories, governing the anomalies of chiral fermionic theories, and Wess-Zumino theories, governing the anomalies of Wess-Zumino terms and self-dual field theories, as extended field theories down to codimension 2.

  2. Galilean Anomalies and Their Effect on Hydrodynamics

    CERN Document Server

    Jain, Akash

    2015-01-01

    We extend the null background construction of [arXiv:1505.05677,arXiv:1509.04718] to include torsion and a conserved spin current, and use it to study gauge and gravitational anomalies in Galilean theories coupled to torsional Newton-Cartan backgrounds. We establish that the relativistic anomaly inflow mechanism with an appropriately modified anomaly polynomial, can be used to generate these anomalies. Similar to relativistic case, we find that Galilean anomalies also survive only in even dimensions. Further, these anomalies only effect the gauge and rotational symmetries of a Galilean theory; in particular the Milne boost symmetry remains non-anomalous. We also extend the transgression machinery used in relativistic fluids to fluids on null backgrounds, and use it to determine how these anomalies affect the constitutive relations of a Galilean fluid. Unrelated to Galilean fluids, we propose an analogue of the off-shell second law of thermodynamics for relativistic fluids introduced by [arXiv:1106.0277], to i...

  3. Cardiac arrest in children

    Directory of Open Access Journals (Sweden)

    Tress Erika

    2010-01-01

    Full Text Available Major advances in the field of pediatric cardiac arrest (CA were made during the last decade, starting with the publication of pediatric Utstein guidelines, the 2005 recommendations by the International Liaison Committee on Resuscitation, and culminating in multicenter collaborations. The epidemiology and pathophysiology of in-hospital and out-of-hospital CA are now well described. Four phases of CA are described and the term "post-cardiac arrest syndrome" has been proposed, along with treatment goals for each of its four phases: immediate post-arrest, early post-arrest, intermediate and recovery phase. Hypothermia is recommended to be considered as a therapy for post-CA syndrome in comatose patients after CA, and large multicenter prospective studies are underway. We reviewed landmark articles related to pediatric CA published during the last decade. We present the current knowledge of epidemiology, pathophysiology and treatment of CA relevant to pre-hospital and acute care health practitioners.

  4. Cardiac arrest in children.

    Science.gov (United States)

    Tress, Erika E; Kochanek, Patrick M; Saladino, Richard A; Manole, Mioara D

    2010-07-01

    Major advances in the field of pediatric cardiac arrest (CA) were made during the last decade, starting with the publication of pediatric Utstein guidelines, the 2005 recommendations by the International Liaison Committee on Resuscitation, and culminating in multicenter collaborations. The epidemiology and pathophysiology of in-hospital and out-of-hospital CA are now well described. Four phases of CA are described and the term "post-cardiac arrest syndrome" has been proposed, along with treatment goals for each of its four phases: immediate post-arrest, early post-arrest, intermediate and recovery phase. Hypothermia is recommended to be considered as a therapy for post-CA syndrome in comatose patients after CA, and large multicenter prospective studies are underway. We reviewed landmark articles related to pediatric CA published during the last decade. We present the current knowledge of epidemiology, pathophysiology and treatment of CA relevant to pre-hospital and acute care health practitioners. PMID:20930971

  5. Socially differentiated cardiac rehabilitation

    DEFF Research Database (Denmark)

    Meillier, Lucette Kirsten; Nielsen, Kirsten Melgaard; Larsen, Finn Breinholt;

    2012-01-01

    recruitment and participation among low educated and socially vulnerable patients must be addressed to lower inequality in post-MI health. Our aim was to improve referral, attendance, and adherence rates among socially vulnerable patients by systematic screening and by offering a socially differentiated...... standard rehabilitation programme (SRP). If patients were identified as socially vulnerable, they were offered an extended version of the rehabilitation programme (ERP). Excluded patients were offered home visits by a cardiac nurse. Concordance principles were used in the individualised programme elements......%. Patients were equally distributed to the SRP and the ERP. No inequality was found in attendance and adherence among referred patients. Conclusions: It seems possible to overcome unequal referral, attendance, and adherence in cardiac rehabilitation by organisation of systematic screening and social...

  6. Gravitational anomalies in higher dimensional Riemann-Cartan space

    International Nuclear Information System (INIS)

    By applying the covariant Taylor expansion method of the heat kernel, the covariant Einstein anomalies associated with a Weyl fermion of spin 1/2 in four-, six- and eight-dimensional Riemann-Cartan space are manifestly given. Many unknown terms with torsion tensors appear in these anomalies. The Lorentz anomaly is intimately related to the Einstein anomaly even in Riemann-Cartan space. The explicit form of the Lorentz anomaly corresponding to the Einstein anomaly is also obtained

  7. Considerations in the Interpretation of Cosmological Anomalies

    CERN Document Server

    Peiris, Hiranya V

    2014-01-01

    Anomalies drive scientific discovery -- they are associated with the cutting edge of the research frontier, and thus typically exploit data in the low signal-to-noise regime. In astronomy, the prevalence of systematics --- both "known unknowns" and "unknown unknowns" --- combined with increasingly large datasets, the widespread use of ad hoc estimators for anomaly detection, and the "look-elsewhere" effect, can lead to spurious false detections. In this informal note, I argue that anomaly detection leading to discoveries of new physics requires a combination of physical understanding, careful experimental design to avoid confirmation bias, and self-consistent statistical methods. These points are illustrated with several concrete examples from cosmology.

  8. Hybrid anomaly-gravity mediation with flavor

    International Nuclear Information System (INIS)

    We study models with contributions of similar size to the soft masses from anomaly-and gravity mediation, thereby curing the tachyonic slepton problem of anomaly mediation. A possible origin of this hybrid setup in a 5-dimensional brane world is briefly discussed. The absence of excessive flavor violation is explained by alignment. The gravitino can be heavy enough so that the gravitino problem of supersymmetric theories with leptogenesis is avoided. The model has a characteristic signature: It predicts the distinctive gaugino mass pattern of anomaly mediation and, at the same time, O(1) slepton mass splittings.

  9. Connections between Schwinger terms and anomalies

    International Nuclear Information System (INIS)

    We present examples of a new type of Schwinger terms appearing in commutators of energy-momentum tensor. We demonstrate them in two-dimensional flat Minkowski space. The Schwinger terms which correspond to gravitational anomaly appear in different places from those of conformal anomaly. Nevertheless, they still preserve the Jacobi identity. We also discuss the relation between anomalies and the Schwinger terms. In any-dimensional curved space-time Faddeev's cohomological technique works well. Therefore we can derive the Schwinger terms in curved space-time. (author)

  10. Fetal renal anomalies : diagnosis, management, and outcome

    OpenAIRE

    Damen-Elias, Henrica Antonia Maria

    2004-01-01

    In two to three percent of fetuses structural anomalies can be found with prenatal ultrasound investigation. Anomalies of the urinary tract account for 15 to 20% of these anomalies with a detection rate of approximately of 90%. In Chapter 2, 3 and 4 we present reference curves for size and growth of fetal kidney, renal pelvis and adrenal gland, preceded by an intra- and interobserver variation analysis. In Chapter 5 we describe the ultrasound findings and outcome of a large cohort of 402 fetu...

  11. On SU(2) anomaly and Majorana fermions

    CERN Document Server

    Patrascu, Andrei

    2015-01-01

    In this paper a loophole in the SU(2) gauge anomaly is presented. It is shown that using several topological tools a theory can be designed that implements the quantization of a single Weyl doublet anomaly free while keeping the non-abelian character of the particle in the theory. This opens the perspective for non-Abelian statistics of deconfined particle like objects in 3+1 dimensions and for applications in Quantum Computing. Moreover, if this loophole cannot be closed, old arguments related to anomaly cancelations must be reviewed.

  12. Crustal structure interpreted from magnetic anomalies

    Science.gov (United States)

    Phillips, Jeffrey D.; Reynolds, Richard L.; Frey, Herbert

    1991-01-01

    This review, discusses publications during the last quadrennium (1987-1990) that used aeromagnetic data, marine magnetic data, satellite magnetic data, and rock magnetic and petrologic data to provide information on the sources of magnetic anomalies. The publications reviewed reflect increased integration of rock magnetic property and petrologic studies with magnetic anomaly interpretation studies, particularly in deep crustal magnetization, exploration for hydrocarbons, and inversion of marine magnetic anomalies. Interpretations of aeromagnetic data featuring image display techniques and using the horizontal gradient method for locating magnetization boundaries became standard.

  13. MULLERIAN DUCT ANOMALY: A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Sunny

    2014-11-01

    Full Text Available The frequency of mullerian duct anomalies vary widely owing to different patient populations, non-standardized classification systems, and differences in diagnostic data acquisition, these anomalies are clinically important, particularly in women who present with infertility. Many of the anomalies are initially diagnosed at hysterosalpingography and ultrasonography; however, further imaging is often required for definitive diagnosis and elaboration of secondary findings. At this time, magnetic resonance imaging is the study of choice because of its high accuracy and detailed elaboration of uterovaginal anatomy. Here, we report a case of 30 years old female who presented to emergency department with bad obstetric history.

  14. Cardiac metastases of osteosarcoma

    International Nuclear Information System (INIS)

    Osteosarcoma is a malignancy whose various sites of metastasis greatly modify its ultimate prognosis. We report a case of simultaneous pulmonary and cardiac metastases in a 41-year-old male patient with osteosarcoma of the tibia, presenting after more then one year of completion of adjuvant therapy with progressive dyspnea and cyanosis. Diagnosis was made on computerized tomogram and echocardiogram. The metastatic mass entirely occupying the right ventricle and the pulmonary artery proved fatal. (author)

  15. Cardiac Tissue Engineering

    OpenAIRE

    MILICA RADISIC; GORDANA VUNJAK-NOVAKOVIC

    2009-01-01

    We hypothesized that clinically sized (1-5 mm thick),compact cardiac constructs containing physiologically high density of viable cells (~108 cells/cm3) can be engineered in vitro by using biomimetic culture systems capable of providing oxygen transport and electrical stimulation, designed to mimic those in native heart. This hypothesis was tested by culturing rat heart cells on polymer scaffolds, either with perfusion of culture medium (physiologic interstitial velocity, supplementation of p...

  16. Cardiac developmental toxicity

    OpenAIRE

    Mahler, Gretchen J.; Jonathan T Butcher

    2011-01-01

    Congenital heart disease is a highly prevalent problem with mostly unknown origins. Many cases of CHD likely involve an environmental exposure coupled with genetic susceptibility, but practical and ethical considerations make nongenetic causes of CHD difficult to assess in humans. The development of the heart is highly conserved across all vertebrate species, making animal models an excellent option for screening potential cardiac teratogens. This review will discuss exposures known to cause ...

  17. Penetrating Cardiac Injuries

    OpenAIRE

    ÖZYAZICIOĞLU, Ahmet

    2002-01-01

    Objectives: To present our experience of penetrating cardiac injuries treated at Atatürk University hospital; in 17 years 38 patients were analyzed. Methods: Patients were classified into three groups: group A (stable), 12; group B (shock), 21; and group C (agonal), five. Five patients were treated by pericardial window and three by pericardiocentesis. Two patients in group C, 19 patients in group B and five patients in group A underwent median sternotomy or thoracotomy in the operating room...

  18. Benign cardiac tumours: cardiac CT and MRI imaging appearances

    International Nuclear Information System (INIS)

    Full text: Primary benign cardiac tumours are rarely found in clinical practice and are generally evaluated with echocardiography. However, with the increasing usage of helical multislice CT, the initial detection and evaluation of these masses may be made by the radiologist during routine daily practice for other indications. The echocardiographic, CT and cardiac MRI appearances of various benign cardiac tumours and masses are described and illustrated in this review

  19. Cardiac tissue engineering

    Directory of Open Access Journals (Sweden)

    MILICA RADISIC

    2005-03-01

    Full Text Available We hypothesized that clinically sized (1-5 mm thick,compact cardiac constructs containing physiologically high density of viable cells (~108 cells/cm3 can be engineered in vitro by using biomimetic culture systems capable of providing oxygen transport and electrical stimulation, designed to mimic those in native heart. This hypothesis was tested by culturing rat heart cells on polymer scaffolds, either with perfusion of culture medium (physiologic interstitial velocity, supplementation of perfluorocarbons, or with electrical stimulation (continuous application of biphasic pulses, 2 ms, 5 V, 1 Hz. Tissue constructs cultured without perfusion or electrical stimulation served as controls. Medium perfusion and addition of perfluorocarbons resulted in compact, thick constructs containing physiologic density of viable, electromechanically coupled cells, in contrast to control constructs which had only a ~100 mm thick peripheral region with functionally connected cells. Electrical stimulation of cultured constructs resulted in markedly improved contractile properties, increased amounts of cardiac proteins, and remarkably well developed ultrastructure (similar to that of native heart as compared to non-stimulated controls. We discuss here the state of the art of cardiac tissue engineering, in light of the biomimetic approach that reproduces in vitro some of the conditions present during normal tissue development.

  20. Indeterminacy of Spatiotemporal Cardiac Alternans

    CERN Document Server

    Zhao, Xiaopeng

    2007-01-01

    Cardiac alternans, a beat-to-beat alternation in action potential duration (at the cellular level) or in ECG morphology (at the whole heart level), is a marker of ventricular fibrillation, a fatal heart rhythm that kills hundreds of thousands of people in the US each year. Investigating cardiac alternans may lead to a better understanding of the mechanisms of cardiac arrhythmias and eventually better algorithms for the prediction and prevention of such dreadful diseases. In paced cardiac tissue, alternans develops under increasingly shorter pacing period. Existing experimental and theoretical studies adopt the assumption that alternans in homogeneous cardiac tissue is exclusively determined by the pacing period. In contrast, we find that, when calcium-driven alternans develops in cardiac fibers, it may take different spatiotemporal patterns depending on the pacing history. Because there coexist multiple alternans solutions for a given pacing period, the alternans pattern on a fiber becomes unpredictable. Usin...

  1. Biosynthesis of cardiac natriuretic peptides

    DEFF Research Database (Denmark)

    Goetze, Jens Peter

    2010-01-01

    Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac p...... competent endocrine cells. The structurally related atrial natriuretic peptide will be mentioned where appropriate, whereas C-type natriuretic peptide will not be considered as a cardiac peptide of relevance in mammalian physiology....... characterized. An ongoing characterization of the molecular heterogeneity will help appreciate the biosynthetic capacity of the endocrine heart and could introduce new diagnostic possibilities. Notably, different biosynthetic products may not be equal markers of the same pathophysiological processes. An...... inefficient post-translational prohormone maturation will also affect the biology of the cardiac natriuretic peptide system. This review aims at summarizing the myocardial synthesis of natriuretic peptides focusing on B-type natriuretic peptide, where new data has disclosed cardiac myocytes as highly...

  2. Biosynthesis of cardiac natriuretic peptides

    DEFF Research Database (Denmark)

    Goetze, Jens Peter

    2010-01-01

    Cardiac-derived peptide hormones were identified more than 25 years ago. An astonishing amount of clinical studies have established cardiac natriuretic peptides and their molecular precursors as useful markers of heart disease. In contrast to the clinical applications, the biogenesis of cardiac...... inefficient post-translational prohormone maturation will also affect the biology of the cardiac natriuretic peptide system. This review aims at summarizing the myocardial synthesis of natriuretic peptides focusing on B-type natriuretic peptide, where new data has disclosed cardiac myocytes as highly...... competent endocrine cells. The structurally related atrial natriuretic peptide will be mentioned where appropriate, whereas C-type natriuretic peptide will not be considered as a cardiac peptide of relevance in mammalian physiology....

  3. Deconstruction and reconstruction of an anomaly

    Czech Academy of Sciences Publication Activity Database

    Engelmann, Dirk; Strobel, M.

    2012-01-01

    Roč. 76, č. 2 (2012), s. 678-689. ISSN 0899-8256 Institutional support: RVO:67985998 Keywords : anomalies * false consensus * information processing Subject RIV: AH - Economics Impact factor: 1.000, year: 2012

  4. Comparison of Unsupervised Anomaly Detection Methods

    Data.gov (United States)

    National Aeronautics and Space Administration — Several different unsupervised anomaly detection algorithms have been applied to Space Shuttle Main Engine (SSME) data to serve the purpose of developing a...

  5. The Pioneer anomaly and the holographic scenario

    OpenAIRE

    Giné, Jaume

    2011-01-01

    In this paper we discuss the recently obtained relation between the Verlinde's holographic model and the first phenomenological Modified Newtonian dynamics. This gives also a promising possible explanation to the Pioneer anomaly.

  6. Design and Implementation of an Anomaly Detector

    Energy Technology Data Exchange (ETDEWEB)

    Bagherjeiran, A; Cantu-Paz, E; Kamath, C

    2005-07-11

    This paper describes the design and implementation of a general-purpose anomaly detector for streaming data. Based on a survey of similar work from the literature, a basic anomaly detector builds a model on normal data, compares this model to incoming data, and uses a threshold to determine when the incoming data represent an anomaly. Models compactly represent the data but still allow for effective comparison. Comparison methods determine the distance between two models of data or the distance between a model and a point. Threshold selection is a largely neglected problem in the literature, but the current implementation includes two methods to estimate thresholds from normal data. With these components, a user can construct a variety of anomaly detection schemes. The implementation contains several methods from the literature. Three separate experiments tested the performance of the components on two well-known and one completely artificial dataset. The results indicate that the implementation works and can reproduce results from previous experiments.

  7. Poland anomaly with contralateral ulnar ray defect.

    OpenAIRE

    Powell, C V; Coombs, R C; David, T J

    1993-01-01

    We report an atypical case of the Poland anomaly. Unreported features are that the hand abnormality is on the contralateral side to the chest wall defect, there is an ulnar ray predominance, and lack of syndactyly.

  8. Coral Reef Watch, Temperature Anomaly, 50 km

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NOAA Coral Reef Watch distributes SST anomaly data using a combination of the POES AVHRR Global Area Coverage data, and data from a climatological database. AVHRR...

  9. Method of Mapping Anomalies in Homogenous Material

    Science.gov (United States)

    Woodard, Stanley E. (Inventor); Taylor, Bryant D. (Inventor)

    2016-01-01

    An electrical conductor and antenna are positioned in a fixed relationship to one another. Relative lateral movement is generated between the electrical conductor and a homogenous material while maintaining the electrical conductor at a fixed distance from the homogenous material. The antenna supplies a time-varying magnetic field that causes the electrical conductor to resonate and generate harmonic electric and magnetic field responses. Disruptions in at least one of the electric and magnetic field responses during this lateral movement are indicative of a lateral location of a subsurface anomaly. Next, relative out-of-plane movement is generated between the electrical conductor and the homogenous material in the vicinity of the anomaly's lateral location. Disruptions in at least one of the electric and magnetic field responses during this out-of-plane movement are indicative of a depth location of the subsurface anomaly. A recording of the disruptions provides a mapping of the anomaly.

  10. SEG US Bouguer Gravity Anomaly Grid

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The SEG gravity data are the product of the ad hoc Gravity Anomaly Map (GAM) Committee, sponsored by the Society of Exploration Geophysicists (SEG) and the U.S....

  11. Anomaly Detection in Transactional Sequential Data

    Directory of Open Access Journals (Sweden)

    Huibing Zhang

    2012-01-01

    Full Text Available A transactional system often has a steady distribution based on their decisions or responses on various transactions. If the system is changed, the distribution also often changes. It is a valuable work to detect anomaly caused by system changes based on different distributions. In this study, we modeled those decision or response signals into a series of time-related distributions and then proposed a method combining distance metrics and anomaly detection to discover whether changes have happened in some systems. Distance metrics on different distributions can decide whether changes have happened and anomaly detection can find what happened further. Extensive experiments show that our method has a good performance and can locate the anomaly accurately.

  12. Seasonal Anomalies in Istanbul Stock Exchange

    Directory of Open Access Journals (Sweden)

    Zehra Abdioglu

    Full Text Available According to efficient market hypothesis, investors perceive all available information in the same manner and it is not possible that any investor obtain more profit than others. Various anomalies in stock markets cause the failure of the efficient market hypothesis. Anomalies mean that the returns of the stock market are different on each the time period. The existence of anomalies in stock markets is important for investors. In this study, it is examined to whether there are seasonal anomalies in Istanbul Stock Exchange. For this purpose, it is tested intra-day effect, day of the week effect, the January effect, intra-month effect, turn of the month effect, turn of the year effect and the holiday effect for the period of 2003-2012, using least squares method. According to results, there is an evidence for intra-day effect and day of the week effect in Istanbul Stock Exchange for this period.

  13. Reduction of satellite magnetic anomaly data

    Science.gov (United States)

    Slud, E. V.; Smith, P. J.; Langel, R. A.

    1984-01-01

    Analysis of global magnetic anomaly maps derived from satellite data is facilitated by inversion to the equivalent magnetization in a constant thickness magnetic crust or, equivalently, by reduction to the pole. Previous inversions have proven unstable near the geomagnetic equator. The instability results from magnetic moment distributions which are admissible in the inversion solution but which make only small contribution to the computed values of anomaly field. Their admissibility in the solution could result from noisy or incomplete data or from small poorly resolved anomalies. The resulting magnetic moments are unrealistically large and oscillatory. Application of the method of principal components (e.g. eigenvalue decomposition and selective elimination of less significant eigenvectors) is proposed as a way of overcoming the instability and the method is demonstrated by applying it to the region around the Bangui anomaly in Central Africa.

  14. Understanding Magnetic Anomalies and Their Significance.

    Science.gov (United States)

    Shea, James H.

    1988-01-01

    Describes a laboratory exercise testing the Vine-Matthews-Morley hypothesis of plate tectonics. Includes 14 questions with explanations using graphs and charts. Provides a historical account of the current plate tectonic and magnetic anomaly theory. (MVL)

  15. US Aeromagnetic and Satellite Magnetic Anomaly Comparisons

    Science.gov (United States)

    Vonfrese, R. R. B.; Hinze, W. J.; Braile, L. W. (Principal Investigator); Sexton, J. L.

    1984-01-01

    Scalar aeromagnetic data obtained by the U.S. Naval Oceanographic Office (NOO) Vector Magnetic Survey of the conterminous U.S. were screened for periods of intense diurnal magnetic activity and reduced to anomaly form, filtered, and continued upward. A number of correlations between the NOO, POGO and preliminary MAGSAT data are evident at satellite elevations, including a prominent transcontinental magnetic high which extends from the Anadarko Basin to the Cincinnati Arch. The transcontinental magnetic high is breached by negative anomalies located over the Rio Grande Rift and Mississippi River Aulacogen. Differentially reduced-to-pole NOO and POGO magnetic anomaly data show that the transcontinental magnetic high corresponds to a well-defined regional trend of negative free-air gravity and enhanced crustal thickness anomalies.

  16. Major congenital anomalies in a Danish region

    DEFF Research Database (Denmark)

    Garne, Ester; Hansen, Anne Vinkel; Birkelund, Anne Sofie; Andersen, Anne Marie Nybo

    2014-01-01

    registry covers live births, foetal deaths with a gestational age (GA) of 20 weeks or more, and terminations of pregnancy due to congenital anomalies (TOPFA). RESULTS: The overall prevalence of congenital anomalies was 2.70% (95% confidence interval: 2.58-2.80). The majority of cases had an isolated......INTRODUCTION: This study describes the prevalence of congenital anomalies and changes over time in birth outcome, mortality and chronic maternal diseases. MATERIAL AND METHODS: This study was based on population data from the EUROCAT registry covering the Funen County, Denmark, 1995-2008. The......: diabetes, epilepsy, mental disorder, thyroid disease, asthma, or inflammatory bowel disease. Medication for these conditions accounted for 46% of maternal drug use. CONCLUSION: Maternal morbidity and use of potentially teratogenic medication have increased among congenital anomaly cases. Foetal and infant...

  17. Mexico Terrain Corrected Free Air Anomalies (97)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' gravity anomaly grid for Mexico, North-Central America and the Western Caribbean Sea is NOT the input data set used in the development of the MEXICO97...

  18. Conformal anomaly around the sudden singularity

    OpenAIRE

    Houndjo, M. J. S.

    2010-01-01

    Quantum effects due to particle creation on a classical sudden singularity have been investigated in a previous work. The conclusion was that quantum effects do not lead to the avoidance nor the modification of the sudden future singularity. In this paper, we investigate quantum corrections coming from conformal anomaly near the sudden future singularity. We conclude that when the equation of state is chosen to be $p=-\\rho-A\\rho^\\alpha$, the conformal anomaly can transform the sudden singular...

  19. Derivation of Crustal Magnetic Anomalies from MAGSAT

    OpenAIRE

    YANAGISAWA, Masahisa

    1984-01-01

    This paper describes various characteristics of the magnetospheric field, induction field, and ionospheric field observed by MAGSAT (Magnetic Field Satellite) and the derivation of crustal magnetic anomalies free from disturbance fields. After eliminating the effect of the disturbance field, anomaly maps were derived for the Japanese area and for the Shatsky Rise area. The magnetic field observed by satellites consists of a core field, induction field, crustal field, ionospheric field, and ma...

  20. Gauge anomalies in Lorentz-violating QED

    CERN Document Server

    Santos, Tiago R S

    2016-01-01

    In this work we study the issue of gauge anomalies in Lorentz-violating QED. To do so, we opt to use the BRST formalism within of the algebraic renormalization approach, reducing our study to a cohomology problem. Since that this approach is independent of the renormalization scheme, the results here obtained are expected to be general. We find that the Lorentz-violating QED is free of gauge anomalies to all orders in perturbation theory.

  1. Anomaly Detection Using Metaheuristic Firefly Harmonic Clustering

    OpenAIRE

    Mario H. A. C. Adaniya; Taufik Abr˜ao; Mario Lemes Proenc¸a Jr.

    2013-01-01

    The performance of communication networks can be affected by a number of factors including misconfiguration, equipments outages, attacks originated from legitimate behavior or not, software errors, among many other causes. These factors may cause an unexpected change in the traffic behavior and create what we call anomalies that may represent a loss of performance or breach of network security. Knowing the behavior pattern of the network is essential to detect and characterize an anomaly. The...

  2. How to quantify structural anomalies in fluids?

    OpenAIRE

    Fomin, Yu. D.; Klumov, B. A.; Ryzhov, V.N.; Tsiok, E. N.

    2014-01-01

    Some fluids are known to behave anomalously. The so-called structural anomaly which means that the fluid becomes less structures under isothermal compression is among the most frequently discussed ones. Several methods for quantifying the degree of structural order are described in the literature and are used for calculating the regions of structural anomalies. It is implied that all of the structural order determinations yield qualitatively identical results. However, no explicit comparison ...

  3. Efficient Accurate Context-Sensitive Anomaly Detection

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    For program behavior-based anomaly detection, the only way to ensure accurate monitoring is to construct an efficient and precise program behavior model. A new program behavior-based anomaly detection model,called combined pushdown automaton (CPDA) model was proposed, which is based on static binary executable analysis. The CPDA model incorporates the optimized call stack walk and code instrumentation technique to gain complete context information. Thereby the proposed method can detect more attacks, while retaining good performance.

  4. Interpretations of the ATLAS Diboson Anomaly

    CERN Document Server

    Cheung, Kingman; Tseng, Po-Yan; Yuan, Tzu-Chiang

    2015-01-01

    Recently, the ATLAS Collaboration recorded an interesting anomaly in diboson production with excesses at the diboson invariant mass around 2 TeV in boosted jets of all the $WZ$, $W^+ W^-$, and $ZZ$ channels. We offer a theoretical interpretation of the anomaly using phenomenological right-handed model with extra $W'$ and $Z'$ bosons. Constraints from narrow total decay widths, leptonic cross sections, and dijet cross sections are taken into account. We also comment on a few other possibilities.

  5. Hyperfine structure and hyperfine anomaly in Pb

    OpenAIRE

    Persson, J. R.

    2014-01-01

    The hyperfine structure in the 6p2-configuration in lead has been analysed and the results is compared with calculations. The hyperfine anomaly and improved values of the nuclear magnetic moment for four lead isotopes is obtained, using the results from the analysis. The results open up for new measurements of the hyperfine structure in unstable lead isotopes, in order to extract information of the hyperfine anomaly and distribution of magnetisation in the nucleus.

  6. Lateral sacral lipomyelomeningocele : a rare anomaly.

    Directory of Open Access Journals (Sweden)

    Shetty D

    2002-04-01

    Full Text Available Lateral sacral lipomyelomeningocele is a rare spinal developmental anomaly. In the case under report, the fat attached to the neural placode was blending with the gluteal fat externally. The cord was tethered at this level. Multiple bony anomalies and diastematomyelia were associated findings. A case of lateral sacral lipomyelomeningocele with excellent imaging detail provided by the multiplanar magnetic resonance (MR scan is reported.

  7. Satellite magnetic anomalies of the Antarctic crust

    Directory of Open Access Journals (Sweden)

    D. E. Alsdorf

    2000-06-01

    Full Text Available Spatially and temporally static crustal magnetic anomalies are contaminated by static core field effects above spherical harmonic degree 12 and dynamic, large-amplitude external fields. To extract crustal magnetic anomalies from the measurements of NASA's Magsat mission, we separate crustal signals from both core and external field effects. In particular, we define Magsat anomalies relative to the degree 11 field and use spectral correlation theory to reduce them for external field effects. We obtain a model of Antarctic crustal thickness by comparing the region's terrain gravity effects to free-air gravity anomalies derived from the Earth Gravity Model 1996 (EGM96. To separate core and crustal magnetic effects, we obtain the pseudo-magnetic effect of the crustal thickness variations from their gravity effect via Poisson's theorem for correlative potentials. We compare the pseudo-magnetic effect of the crustal thickness variations to field differences between degrees 11 and 13 by spectral correlation analysis. We thus identify and remove possible residual core field effects in the Magsat anomalies relative to the degree 11 core field. The resultant anomalies reflect possible Antarctic contrasts due both to crustal thickness and intracrustal variations of magnetization. In addition, they provide important constraints on the geologic interpretation of aeromagnetic survey data, such as are available for the Weddell Province. These crustal anomalies also may be used to correct for long wavelength errors in regional compilations of near-surface magnetic survey data. However, the validity of these applications is limited by the poor quality of the Antarctic Magsat data that were obtained during austral Summer and Fall when south polar external field activity was maximum. Hence an important test and supplement for the Antarctic crustal Magsat anomaly map will be provided by the data from the recently launched Ørsted mission, which will yield coverage

  8. Flavour Violation in Anomaly Mediated Supersymmetry Breaking

    OpenAIRE

    Allanach, B. C.; Hiller, G; Jones, D. R. T.; Slavich, P.(LPTHE, UPMC Univ. Paris 06, Sorbonne Universités, 4 Place Jussieu, 75252, Paris, France)

    2009-01-01

    32 pages, 8 figures International audience We study squark flavour violation in the anomaly mediated supersymmetry broken (AMSB) minimal supersymmetric standard model. Analytical expressions for the three-generational squark mass matrices are derived. We show that the anomaly-induced soft breaking terms have a decreasing amount of squark flavour violation when running from the GUT to the weak scale. Taking into account inter-generational squark mixing, we work out non-trivial constraint...

  9. Anomalous transport due to scale anomaly

    OpenAIRE

    Chernodub, M.N.

    2016-01-01

    We show that the scale anomaly in field theories leads to new anomalous transport effects that emerge in external electromagnetic field in inhomogeneous gravitational background. In inflating geometry the QED scale anomaly generates electric current which flows in opposite direction with respect to background electric field. In static spatially inhomogeneous gravitational background the dissipationless electric current flows transversely both to the magnetic field axis and to the gradient of ...

  10. Anomalous transport due to scale anomaly

    CERN Document Server

    Chernodub, M N

    2016-01-01

    We show that the scale anomaly in field theories leads to new anomalous transport effects that emerge in external electromagnetic field in inhomogeneous gravitational background. In inflating geometry the QED scale anomaly generates electric current which flows in opposite direction with respect to background electric field. In static spatially inhomogeneous gravitational background the dissipationless electric current flows transversely both to the magnetic field axis and to the gradient of the inhomogeneity. The anomalous currents are proportional to the beta function of the theory.

  11. MAGNETIC ANOMALY IN SUPERCONDUCTING FeSe

    OpenAIRE

    Mendoza, D.; Benitez, J. L.; Morales, F.; Escudero, R.

    2010-01-01

    Synthesis, electrical and magnetic characterization of superconducting FeSe0.85 compound is reported. An anomaly in the magnetization against temperature around 90K is observed. Magnetic characterization of a commercial compound with nominal FeSe stoichiometry is also presented. The overall magnetic behaviors as well as the magnetic anomaly in both compounds are discussed in terms of magnetic impurities and secondary phases. Keyword: A. Superconductors

  12. Singlet deflected anomaly/gauge mediation

    OpenAIRE

    de Blas, J.; Delgado, A

    2011-01-01

    We study an extension of the standard anomaly/gauge mediation scenario where the messenger fields have direct interactions with an extra gauge singlet. This realizes a phenomenologically viable NMSSM-like scenario free of the mu-b_mu problem. Current cosmological constraints imply a small size for the anomaly-mediation contributions, unless some source of R-parity violation is permitted. In the latter case the allowed regions in the parameter space can be substantially larger than in the corr...

  13. Sudden Cardiac Death in Athletes.

    Science.gov (United States)

    Wasfy, Meagan M; Hutter, Adolph M; Weiner, Rory B

    2016-01-01

    There are clear health benefits to exercise; even so, patients with cardiac conditions who engage in exercise and athletic competition may on rare occasion experience sudden cardiac death (SCD). This article reviews the epidemiology and common causes of SCD in specific athlete populations. There is ongoing debate about the optimal mechanism for SCD prevention, specifically regarding the inclusion of the ECG and/or cardiac imaging in routine preparticipation sports evaluation. This controversy and contemporary screening recommendations are also reviewed. PMID:27486488

  14. Cardiac Rehabilitation: Guidelines and Recommendations

    OpenAIRE

    Catherine Monpere

    1998-01-01

    Cardiac rehabilitation has been shown to improve exercise tolerance and symptomatology in patients experiencing angina or heart failure and reduce long term mortality after myocardial infarction, with a good cost-effectiveness ratio. In addition to these `hard' endpoints, cardiac rehabilitation improves the patient's quality of life and risk factor profile through a multifactorial intervention. Indeed, cardiac rehabilitation is no longer restricted to physical reconditioning, but should now b...

  15. Uterine didelphys with obstructed hemivagina and ipsilateral renal anomaly - OHVIRA syndrome: a rare congenital anomaly

    OpenAIRE

    Bhimarao Patil; Rashmi Mysore Nagaraju

    2015-01-01

    OHVIRA or Herlyn-Werner-Wunderlich syndrome is a rare congenital anomaly characterized by uterine anomaly with obstructed hemivagina and ipsilateral renal anomaly. We present a case of 16 year female who presented with cyclical lower abdominal pain. Ultrasonography and computed tomography in this patient revealed classic triad of findings. Our case is significant as the diagnosis was made at an earlier stage of the disease before development of gross obstruction and hematometrocolpos. [Int J ...

  16. Evaluating Real-time Anomaly Detection Algorithms - the Numenta Anomaly Benchmark

    OpenAIRE

    Lavin, Alexander; Ahmad, Subutai

    2015-01-01

    Much of the world's data is streaming, time-series data, where anomalies give significant information in critical situations; examples abound in domains such as finance, IT, security, medical, and energy. Yet detecting anomalies in streaming data is a difficult task, requiring detectors to process data in real-time, not batches, and learn while simultaneously making predictions. There are no benchmarks to adequately test and score the efficacy of real-time anomaly detectors. Here we propose t...

  17. Classifying gauge anomalies through symmetry-protected trivial orders and classifying gravitational anomalies through topological orders

    Science.gov (United States)

    Wen, Xiao-Gang

    2013-08-01

    In this paper, we systematically study gauge anomalies in bosonic and fermionic weak-coupling gauge theories with gauge group G (which can be continuous or discrete) in d space-time dimensions. We show a very close relation between gauge anomalies for gauge group G and symmetry-protected trivial (SPT) orders (also known as symmetry-protected topological (SPT) orders) with symmetry group G in one-higher dimension. The SPT phases are classified by group cohomology class Hd+1(G,R/Z). Through a more careful consideration, we argue that the gauge anomalies are described by the elements in Free[Hd+1(G,R/Z)]⊕Hπ˙d+1(BG,R/Z). The well known Adler-Bell-Jackiw anomalies are classified by the free part of Hd+1(G,R/Z) (denoted as Free[Hd+1(G,R/Z)]). We refer to other kinds of gauge anomalies beyond Adler-Bell-Jackiw anomalies as non-ABJ gauge anomalies, which include Witten SU(2) global gauge anomalies. We introduce a notion of π-cohomology group, Hπ˙d+1(BG,R/Z), for the classifying space BG, which is an Abelian group and include Tor[Hd+1(G,R/Z)] and topological cohomology group Hd+1(BG,R/Z) as subgroups. We argue that Hπ˙d+1(BG,R/Z) classifies the bosonic non-ABJ gauge anomalies and partially classifies fermionic non-ABJ anomalies. Using the same approach that shows gauge anomalies to be connected to SPT phases, we can also show that gravitational anomalies are connected to topological orders (i.e., patterns of long-range entanglement) in one-higher dimension.

  18. Hamiltonian anomalies from extended field theories

    CERN Document Server

    Monnier, Samuel

    2014-01-01

    We develop a proposal by Freed to see anomalous field theories as relative field theories, namely field theories taking value in a field theory in one dimension higher, the anomaly field theory. We show that when the anomaly field theory is extended down to codimension 2, familiar facts about Hamiltonian anomalies can be naturally recovered, such as the fact that the anomalous symmetry group admits only a projective representation on the Hilbert space, or that the latter is really an abelian bundle gerbe over the moduli space. We include in the discussion the case of non-invertible anomaly field theories, which is relevant to six-dimensional (2,0) superconformal theories. In this case, we show that the Hamiltonian anomaly is characterized by a degree 2 non-abelian group cohomology class, associated to the non-abelian gerbe playing the role of the state space of the anomalous theory. We construct Dai-Freed theories, governing the anomalies of chiral fermionic theories, and Wess-Zumino theories, governing the a...

  19. Diagnostic imaging of cardiac hypertrophy

    International Nuclear Information System (INIS)

    As imaging techniques for cardiac hypertrophy, the ultrasonic dimension gauze technique, echocardiography, ventriculography and the RI technique including emission RI tomography were outlined. (Chiba, N.)

  20. Clustering and Recurring Anomaly Identification: Recurring Anomaly Detection System (ReADS)

    Science.gov (United States)

    McIntosh, Dawn

    2006-01-01

    This viewgraph presentation reviews the Recurring Anomaly Detection System (ReADS). The Recurring Anomaly Detection System is a tool to analyze text reports, such as aviation reports and maintenance records: (1) Text clustering algorithms group large quantities of reports and documents; Reduces human error and fatigue (2) Identifies interconnected reports; Automates the discovery of possible recurring anomalies; (3) Provides a visualization of the clusters and recurring anomalies We have illustrated our techniques on data from Shuttle and ISS discrepancy reports, as well as ASRS data. ReADS has been integrated with a secure online search

  1. Classifying gauge anomalies through SPT orders and classifying anomalies through topological orders

    CERN Document Server

    Wen, Xiao-Gang

    2013-01-01

    In this paper, we systematically study gauge anomalies in bosonic and fermionic weak-coupling gauge theories with gauge group G (which can be continuous or discrete). We argue that, in d space-time dimensions, the gauge anomalies are described by the elements in Free[H^{d+1}(G,R/Z)]\\oplus H_\\pi^{d+1}(BG,R/Z). The well known Adler-Bell-Jackiw anomalies are classified by the free part of the group cohomology class H^{d+1}(G,R/Z) of the gauge group G (denoted as Free[H^{d+1}(G,\\R/\\Z)]). We refer other kinds of gauge anomalies beyond Adler-Bell-Jackiw anomalies as nonABJ gauge anomalies, which include Witten SU(2) global gauge anomaly. We introduce a notion of \\pi-cohomology group, H_\\pi^{d+1}(BG,R/Z), for the classifying space BG, which is an Abelian group and include Tor[H^{d+1}(G,R/Z)] and topological cohomology group H^{d+1}(BG,\\R/\\Z) as subgroups. We argue that H_\\pi^{d+1}(BG,R/Z) classifies the bosonic nonABJ gauge anomalies, and partially classifies fermionic nonABJ anomalies. We also show a very close rel...

  2. Cardiac manifestations of myotonic dystrophy type 1

    DEFF Research Database (Denmark)

    Petri, Helle; Vissing, John; Witting, Nanna; Bundgaard, Henning; Køber, Lars

    2012-01-01

    To estimate the degree of cardiac involvement regarding left ventricular ejection fraction, conduction abnormalities, arrhythmia, risk of sudden cardiac death (SCD) and the associations between cardiac involvement and cytosine-thymine-guanine (CTG)-repeat, neuromuscular involvement, age and gender...

  3. Antifibrinolytics in cardiac surgery

    Directory of Open Access Journals (Sweden)

    Achal Dhir

    2013-01-01

    Full Text Available Cardiac surgery exerts a significant strain on the blood bank services and is a model example in which a multi-modal blood-conservation strategy is recommended. Significant bleeding during cardiac surgery, enough to cause re-exploration and/or blood transfusion, increases morbidity and mortality. Hyper-fibrinolysis is one of the important contributors to increased bleeding. This knowledge has led to the use of anti-fibrinolytic agents especially in procedures performed under cardiopulmonary bypass. Nothing has been more controversial in recent times than the aprotinin controversy. Since the withdrawal of aprotinin from the world market, the choice of antifibrinolytic agents has been limited to lysine analogues either tranexamic acid (TA or epsilon amino caproic acid (EACA. While proponents of aprotinin still argue against its non-availability. Health Canada has approved its use, albeit under very strict regulations. Antifibrinolytic agents are not without side effects and act like double-edged swords, the stronger the anti-fibrinolytic activity, the more serious the side effects. Aprotinin is the strongest in reducing blood loss, blood transfusion, and possibly, return to the operating room after cardiac surgery. EACA is the least effective, while TA is somewhere in between. Additionally, aprotinin has been implicated in increased mortality and maximum side effects. TA has been shown to increase seizure activity, whereas, EACA seems to have the least side effects. Apparently, these agents do not differentiate between pathological and physiological fibrinolysis and prevent all forms of fibrinolysis leading to possible thrombotic side effects. It would seem prudent to select the right agent knowing its risk-benefit profile for a given patient, under the given circumstances.

  4. Single ventricle cardiac defect

    International Nuclear Information System (INIS)

    Single ventricle heart is defined as a rare cardiac abnormality with a single ventricle chamber involving diverse functional and physiological defects. Our case is of a ten month-old baby boy who died shortly after admission to the hospital due to vomiting and diarrhoea. Autopsy findings revealed cyanosis of finger nails and ears. Internal examination revealed; large heart, weighing 60 grams, single ventricle, without a septum and upper membranous part. Single ventricle is a rare pathology, hence, this paper aims to discuss this case from a medico-legal point of view. (author)

  5. Abdominal aortic surgery and renal anomalies

    Directory of Open Access Journals (Sweden)

    Ilić Nikola

    2011-01-01

    Full Text Available Introduction. Kidney anomalies present a challenge even for the most experienced vascular surgeon in the reconstruction of the aortoilliac segment. The most significant anomalies described in the surgery of the aortoilliac segment are a horse-shoe and ectopic kidney. Objective. The aim of this retrospective study was to analyze experience on 40 patients with renal anomalies, who underwent surgery of the aortoilliac segment and to determine attitudes on conventional surgical treatment. Methods. In the period from 1992 to 2009, at the Clinic for Vascular Surgery of the Clinical Centre of Belgrade we operated on 40 patients with renal anomalies and aortic disease (aneurysmatic and obstructive. The retrospective analysis involved standard epidemiological data of each patient (gender, age, risk factors for atherosclerosis, type of anomaly, type of aortic disease, presurgical parameter values of renal function, type of surgical approach (laparatomy or retroperitoneal approach, classification of the renal isthmus, reimplantation of renal arteries and perioperative morbidity and mortality. Results. Twenty patients were males In 30 (70% patients we diagnosed a horse-shoe kidney and in 10 (30% ectopic kidney. In the cases of ruptured aneurysm of the abdominal aorta the diagnosis was made by ultrasound findings. Pre-surgically, renal anomalies were confirmed in all patients, except in those with a ruptured aneurysm who underwent urgent surgery. In all patients we applied medial laparatomy, except in those with a thoracoabdominal aneurysm type IV, when the retroperitonal approach was necessary. On average the patients were under follow-up for 6.2 years (from 6 months to 17 years. Conclusion. Under our conditions, the so-called double clamp technique with the preservation of the kidney gave best results in the patients with renal anomalies and aortic disease.

  6. Anaesthetic management of patients with congenital heart disease presenting for non-cardiac surgery.

    OpenAIRE

    Mohindra R; Beebe David; Belani Kumar

    2002-01-01

    The incidence of congenital heart disease is about one percent of all live births in the United States. Treatment is being performed at a younger age and these children are showing improved survival. It is not unusual for children with congenital heart disease to present for non-cardiac surgery. Their management depends on their age, type of lesion, extent of corrective procedure, the presence of complications and other congenital anomalies. Each patient needs a detailed pre-operative evaluat...

  7. Sudden cardiac death in children and adolescents (excluding Sudden Infant Death Syndrome)

    International Nuclear Information System (INIS)

    Sudden death in the young is rare. About 25% of cases occur during sports. Most young people with sudden cardiac death (SCD) have underlying heart disease, with hypertrophic cardiomyopathy and coronary artery anomalies being commonest in most series. Arrhythmogenic right ventricular dysplasia and long QT syndrome are the most common primary arrhythmic causes of SCD. It is estimated that early cardiopulmonary resuscitation and widespread availability of automatic external defibrillators could prevent about a quarter of pediatric sudden deaths

  8. Sudden cardiac death in children and adolescents (excluding Sudden Infant Death Syndrome)

    OpenAIRE

    Gajewski Kelly; Saul Philip

    2010-01-01

    Sudden death in the young is rare. About 25% of cases occur during sports. Most young people with sudden cardiac death (SCD) have underlying heart disease, with hypertrophic cardiomyopathy and coronary artery anomalies being commonest in most series. Arrhythmogenic right ventricular dysplasia and long QT syndrome are the most common primary arrhythmic causes of SCD. It is estimated that early cardiopulmonary resuscitation and widespread availability of automatic external defibrillators...

  9. A Mobile Device System for Early Warning of ECG Anomalies

    Directory of Open Access Journals (Sweden)

    Adam Szczepański

    2014-06-01

    Full Text Available With the rapid increase in computational power of mobile devices the amount of ambient intelligence-based smart environment systems has increased greatly in recent years. A proposition of such a solution is described in this paper, namely real time monitoring of an electrocardiogram (ECG signal during everyday activities for identification of life threatening situations. The paper, being both research and review, describes previous work of the authors, current state of the art in the context of the authors’ work and the proposed aforementioned system. Although parts of the solution were described in earlier publications of the authors, the whole concept is presented completely for the first time along with the prototype implementation on mobile device—a Windows 8 tablet with Modern UI. The system has three main purposes. The first goal is the detection of sudden rapid cardiac malfunctions and informing the people in the patient’s surroundings, family and friends and the nearest emergency station about the deteriorating health of the monitored person. The second goal is a monitoring of ECG signals under non-clinical conditions to detect anomalies that are typically not found during diagnostic tests. The third goal is to register and analyze repeatable, long-term disturbances in the regular signal and finding their patterns.

  10. Hypokalemia and sudden cardiac death

    DEFF Research Database (Denmark)

    Kjeldsen, Keld

    2010-01-01

    Worldwide, approximately three million people suffer sudden cardiac death annually. These deaths often emerge from a complex interplay of substrates and triggers. Disturbed potassium homeostasis among heart cells is an example of such a trigger. Thus, hypokalemia and, also, more transient...... of fatal arrhythmia and sudden cardiac death a patient is, the more attention should be given to the potassium homeostasis....

  11. Atrial tumors in cardiac MRI

    International Nuclear Information System (INIS)

    Cardiac magnetic resonance imaging (MRI) is an important tool for the diagnosis of cardiac masses. Various cardiac tumors are predisposed to occurring in atrial structures. The aim of this review article is the description of atrial tumors and their morphological features in MRI. In general, cardiac tumors are rare: approximately 0.001-0.03% in autopsy studies. About 75% of them are benign. The most common cardiac tumor is the myxoma. They are predisposed to occur in the atria and show a characteristically strong hyperintense signal on T2-wieghted images in MRI. In other sequences a heterogeneous pattern reflects its variable histological appearance. Lipomas exhibit a signal behavior identical to fatty tissue with a typical passive movement in cine imaging. Fibroelastomas are the most common tumors of the cardiac valves. Consisting of avascular fibrous tissue, they often present with hypointense signal intensities. Thrombi attached to their surface can cause severe emboli even in small tumors. Amongst primary cardiac malignancies, sarcomas are most common and favor the atria. Secondary malignancies of the heart are far more common than primary ones (20-40 times). In case of known malignancies, approximately 10% of patients develop cardiac metastasis at the end of their disease. Lymphogenic metastases favor the pericardium, while hematogenic spread prefers the myocardium. Since they are not real atrial tumors, thrombi and anatomical structures of the atria have to be differentiated from other pathologies. (orig.)

  12. Cardiac arrest – cardiopulmonary resuscitation

    Directory of Open Access Journals (Sweden)

    Basri Lenjani

    2014-01-01

    Conclusions: All survivors from cardiac arrest have received appropriate medical assistance within 10 min from attack, which implies that if cardiac arrest occurs near an institution health care (with an opportunity to provide the emergent health care the rate of survival is higher.

  13. Pneumothorax in cardiac pacing

    DEFF Research Database (Denmark)

    Kirkfeldt, Rikke Esberg; Johansen, Jens Brock; Nohr, Ellen Aagaard;

    2012-01-01

    AIM: To identify risk factors for pneumothorax treated with a chest tube after cardiac pacing device implantation in a population-based cohort.METHODS AND RESULTS: A nationwide cohort study was performed based on data on 28 860 patients from the Danish Pacemaker Register, which included all Danish...... patients who received their first pacemaker (PM) or cardiac resynchronization device from 1997 to 2008. Multiple logistic regression was used to estimate adjusted odds ratios (aOR) with 95% confidence intervals for the association between risk factors and pneumothorax treated with a chest tube. The median...... age was 77 years (25th and 75th percentile: 69-84) and 55% were male (n = 15 785). A total of 190 patients (0.66%) were treated for pneumothorax, which was more often in women [aOR 1.9 (1.4-2.6)], and in patients with age >80 years [aOR 1.4 (1.0-1.9)], a prior history of chronic obstructive pulmonary...

  14. Leadership in cardiac surgery.

    Science.gov (United States)

    Rao, Christopher; Patel, Vanash; Ibrahim, Michael; Ahmed, Kamran; Wong, Kathie A; Darzi, Ara; von Segesser, Ludwig K; Athanasiou, Thanos

    2011-06-01

    Despite the efficacy of cardiac surgery, less invasive interventions with more uncertain long-term outcomes are increasingly challenging surgery as first-line treatment for several congenital, degenerative and ischemic cardiac diseases. The specialty must evolve if it is to ensure its future relevance. More importantly, it must evolve to ensure that future patients have access to treatments with proven long-term effectiveness. This cannot be achieved without dynamic leadership; however, our contention is that this is not enough. The demands of a modern surgical career and the importance of the task at hand are such that the serendipitous emergence of traditional charismatic leadership cannot be relied upon to deliver necessary change. We advocate systematic analysis and strategic leadership at a local, national and international level in four key areas: Clinical Care, Research, Education and Training, and Stakeholder Engagement. While we anticipate that exceptional individuals will continue to shape the future of our specialty, the creation of robust structures to deliver collective leadership in these key areas is of paramount importance. PMID:20884217

  15. Cardiac chamber scintiscanning

    International Nuclear Information System (INIS)

    The two methods of cardiac chamber scintiscanning, i.e. 'first pass' and 'ECG-triggered' examinations, are explained and compared. Two tables indicate the most significant radiation doses of the applied radio tracers, i.e. 99m-Tc-pertechnetate and 99m-Tc-HSA, to which a patient is exposed. These averaged values are calculated from various data given in specialised literature. On the basis of data given in literature, an effective half-life of approximately 5 hours in the intravascular space was calculated for the erythrocytes labelled with technetium 99m. On this basis, the radiation doses for the patients due to 99m-Tc-labelled erythrocytes are estimated. The advantages and disadvantages of the two methods applied for cardiac chamber scintiscanning are put into contrast and compared with the advantages and disadvantages of the quantitative X-ray cardiography of the left heart. The still existing problems connected with the assessment of ECG-triggered images are discussed in detail. The author performed investigations of his own, which concerned the above-mentioned problems. (orig./MG)

  16. Geological reasons for change in intensity of linear magnetic anomalies of the Kursk magnetic anomaly

    Science.gov (United States)

    Zhavoronkin, I. A.; Kopayev, V. V.

    1985-01-01

    The geological reasons for fluctuations in the anomalous field intensity along the polar axes were examined. The Kursk magnetic anomaly is used as the basis for the study. A geological-geophysical section was constructed which used the results of the interpretation of gravimagnetic anomalies.

  17. Application of ultrasound in fetal cardiac abnormalitis screening and analyzing of influencing factors

    International Nuclear Information System (INIS)

    Objective: To identify the application value of ultrasound in the screening of fetal cardiac abnormalities and to reduce its affecting factors, in order to maximally decrease the birth of oaf. Methods: Adopting the method of four chamber hearts cross-section and sound beam plane head laterodeviation, 3821 fetal hearts were screened by ultrasonocardiography in middle and late fetal period. The influencing factors were also analyzed. Screening results were compared with the autopsy following induced labor and the ultrasonocardiogram after borne. Results: Total 23 cases of the cardiac anomalies were confirmed by odinopoeia or after borned, 21 cases were diagnosed by antepartum ultrasonocardiography, the detectable rate were 91.3%(21/23). And the complex cardiac anomalies were 19 cases, accounted for 82.61%(19/23), the general malformation were 4 cases, accounted for 17.39%(4/23). In 19 cases of the complex anomalies, 17 cases were diagnosed by antepartum examination in the first time, 2 cases were diagnosed by reexamination, the total detectable rate were 100%(19/19). Conclusion: Ultrasonography is not only non-invasive but also unique method in detecting fetal heart defects. It will help to diagnose definitely the vast majority of congenital malformation in the fetal heart, especially complex malformation in the middle and later fetal period. There are some limitations and chronergy in ultrasonography for the screening of fetal heart defects, which should be followed-up when the fetal appeared 'normal' in the early screening. (authors)

  18. Affect intensity and cardiac arousal.

    Science.gov (United States)

    Blascovich, J; Brennan, K; Tomaka, J; Kelsey, R M; Hughes, P; Coad, M L; Adlin, R

    1992-07-01

    Relationships between affect intensity and basal, evoked, and perceived cardiac arousal were investigated in 3 experiments. Affect intensity was assessed using Larsen and Diener's (1987) Affect Intensity Measure (AIM). Cardiac arousal was evoked with exercise in the 1st study and with mental arithmetic in the 2nd and 3rd. Perceived cardiac arousal was measured under optimal conditions using a standard heartbeat discrimination procedure. Women as a group scored higher on the AIM. Affect intensity was unrelated to basal or evoked cardiac arousal and was negatively related to perceived cardiac arousal in all 3 studies. Data suggest that affect intensity, although unrelated to actual physiological arousal, is negatively related to the accuracy with which individuals perceive their own arousal. Results are discussed within the context of an expanded arousal-regulation model (Blascovich, 1990). PMID:1494983

  19. Hyperspectral Anomaly Detection in Urban Scenarios

    Science.gov (United States)

    Rejas Ayuga, J. G.; Martínez Marín, R.; Marchamalo Sacristán, M.; Bonatti, J.; Ojeda, J. C.

    2016-06-01

    We have studied the spectral features of reflectance and emissivity in the pattern recognition of urban materials in several single hyperspectral scenes through a comparative analysis of anomaly detection methods and their relationship with city surfaces with the aim to improve information extraction processes. Spectral ranges of the visible-near infrared (VNIR), shortwave infrared (SWIR) and thermal infrared (TIR) from hyperspectral data cubes of AHS sensor and HyMAP and MASTER of two cities, Alcalá de Henares (Spain) and San José (Costa Rica) respectively, have been used. In this research it is assumed no prior knowledge of the targets, thus, the pixels are automatically separated according to their spectral information, significantly differentiated with respect to a background, either globally for the full scene, or locally by image segmentation. Several experiments on urban scenarios and semi-urban have been designed, analyzing the behaviour of the standard RX anomaly detector and different methods based on subspace, image projection and segmentation-based anomaly detection methods. A new technique for anomaly detection in hyperspectral data called DATB (Detector of Anomalies from Thermal Background) based on dimensionality reduction by projecting targets with unknown spectral signatures to a background calculated from thermal spectrum wavelengths is presented. First results and their consequences in non-supervised classification and extraction information processes are discussed.

  20. The Hubble Space Telescope attitude observer anomaly

    Science.gov (United States)

    Van Arsdall, Morgan M.; Ramsey, Patrick R.; Swain, Scott R.

    2006-06-01

    In mid-2004, the Hubble Space Telescope (HST) began experiencing occasional losses of lock during Fine Guidance Sensor (FGS) guide star acquisitions, threatening a potential loss of science. These failures were associated with an increasing disparity between the FGS-derived estimates of gyro bias calculated in orbit day and those calculated in orbit night. Early efforts to mitigate the operational effects of this Attitude Observer Anomaly (AOA) succeeded; however, the magnitude of the anomaly continued to increase at a linear rate and operational problems resumed in mid-2005. Continued analysis led to an additional on-orbit mitigation strategy that succeeded in reducing the AOA signature. Before the investigation could be completed, HST began operations under the life-extending Two Gyro Science mode. This eliminated both the operational effects of and the visibility into the AOA phenomenon. Possible causes of the anomaly at the vehicle system level included component hardware failures, flight software errors in control law processing, distortion of the telescope optical path, and deformation of vehicle structure. Although the mechanism of the AOA was not definitively identified, the Anomaly Review Board (ARB) chartered to investigate the anomaly concluded that the most likely root cause lies within one of HST's 6 rate-integrating gyroscopes. This paper provides a summary of the initial paths of investigation, the analysis and testing performed to attempt to isolate the source, and a review of the findings of the ARB. The possibility of future operational impacts and available methods of on-orbit mitigation are also addressed.

  1. Gravity anomalies; 1 : 1 000 000

    International Nuclear Information System (INIS)

    On this map the gravity anomalies on the territory of the Slovak Republic are shown. Complete Bouguer anomalies are calculated from the data obtained by gravimetric mapping made by Geofyzika Brno and its branches in Brno, Bratislava, and Prague. The measurement was carried out in the years 1958 - 1992 with point density of 3 - 6 points.km-2 with the exception of the area of the Vysoke Tatry Mts., where this density could not be maintained. The gravity was surveyed on more than 230,000 points by Worden, Canadian CG-2 and GAK PT gravimeters. The accuracy of gravity determination and calculation of the complete Bouguer anomalies allow for interpolation of isolines by 0.5 mGal. The map of complete Bouguer anomalies has been compiled for the reduction density of 2.67 kg.dm-3, the referential Baltic Vertical Datum after adjustment, was used, the normal gravity acceleration is calculated by the formula GRS80, the Bullard member is taken into consideration, and the topographic corrections are calculated to the distance of 166.7 km. The resulting anomaly was recalculated to the IGSN71 absolute gravimetric system. (author)

  2. Hyperbolic Orbits and the Planetary Flylby Anomaly

    Science.gov (United States)

    Wilson, T.L.; Blome, H.J.

    2009-01-01

    Space probes in the Solar System have experienced unexpected changes in velocity known as the flyby anomaly [1], as well as shifts in acceleration referred to as the Pioneer anomaly [2-4]. In the case of Earth flybys, ESA s Rosetta spacecraft experienced the flyby effect and NASA s Galileo and NEAR satellites did the same, although MESSENGER did not possibly due to a latitudinal property of gravity assists. Measurements indicate that both anomalies exist, and explanations have varied from the unconventional to suggestions that new physics in the form of dark matter might be the cause of both [5]. Although dark matter has been studied for over 30 years, there is as yet no strong experimental evidence supporting it [6]. The existence of dark matter will certainly have a significant impact upon ideas regarding the origin of the Solar System. Hence, the subject is very relevant to planetary science. We will point out here that one of the fundamental problems in science, including planetary physics, is consistency. Using the well-known virial theorem in astrophysics, it will be shown that present-day concepts of orbital mechanics and cosmology are not consistent for reasons having to do with the flyby anomaly. Therefore, the basic solution regarding the anomalies should begin with addressing the inconsistencies first before introducing new physics.

  3. Etiology and Evaluation of Sperm Chromatin Anomalies

    Directory of Open Access Journals (Sweden)

    Marziyeh Tavalaee

    2008-01-01

    Full Text Available Evidence suggests that human sperm chromatin anomalies adversely affect reproductive outcomesand infertile men possess substantially amount of sperm with chromatin anomalies than fertilemen.Routine semen analysis evaluates parameters such as sperm motility and morphology, but doesnot examine the nuclear DNA integrity of spermatozoa. It has been suggested that altered nuclearchromatin structure or damaged DNA in spermatozoa could modify the special cellular functionsof human spermatozoa, and thereby affect the fertility potential. Intra-cytoplasmic sperm injection(ICSI bypass the barriers to fertilization for such a sperm, then the effect of chromatin anomalies onthe development remains a concern. Therefore, it is essential to develop and use accurate diagnostictests, which may provide better prognostic capabilities than the standard sperm assessments. Thisreview discusses our current understanding of the structure and organization of sperm DNA,the different procedures for assessment of sperm chromatin anomalies including comet assay,Chromomycin A3 (CMA3, sperm chromatin structure assay (SCSA, acridine orange test (AOT,terminal TdT-mediated dUTP-nick-end labelling (TUNEL assay, aniline blue and sperm chromatindispersion (SCD test and the impact of chromatin anomalies on reproductive outcome.

  4. Distributed Anomaly Detection using Minimum Volume Elliptical Principal Component Analysis

    OpenAIRE

    O'Reilly, CE; Gluhak, A.; Imran, A.

    2016-01-01

    Principal component analysis and the residual error is an effective anomaly detection technique. In an environment where anomalies are present in the training set, the derived principal components can be skewed by the anomalies. A further aspect of anomaly detection is that data might be distributed across different nodes in a network and their communication to a centralized processing unit is prohibited due to communication cost. Current solutions to distributed anomaly detection rely on a h...

  5. Satellite anomalies caused by disturbed space weather

    Science.gov (United States)

    Allen, J. H.

    2003-04-01

    Seven types of satellite anomalies are discussed and examples are given from historical reports. Types of anomalies and their causes are: o Single Event Upsets (SEU) caused by penetrating energetic ions; o Deep dielectric ("bulk") charging (DDC) by high-energy electrons; o Surface charging by thermal electrons causing electrostatic discharge (ESD) and Phantom Commands (PC); o Magnetopause crossing events (MPE) that reverse ambient fields at geostationary satellite altitudes; o dB/dT of field-aligned currents causing satellite tumbling at lower altitudes; o Optical effects of high-energy ions on star-trackers and limb sensors; and o Power panel degradation from high-energy ions. Recent and older events are considered, in part because the problems recur even though technology has changed to take them into account and awareness of the conditions causing them seems widespread. Systematic anomaly reporting is requested to increase the significance of records collected for particular events.

  6. Anomaly-based Network Intrusion Detection Methods

    Directory of Open Access Journals (Sweden)

    Pavel Nevlud

    2013-01-01

    Full Text Available The article deals with detection of network anomalies. Network anomalies include everything that is quite different from the normal operation. For detection of anomalies were used machine learning systems. Machine learning can be considered as a support or a limited type of artificial intelligence. A machine learning system usually starts with some knowledge and a corresponding knowledge organization so that it can interpret, analyse, and test the knowledge acquired. There are several machine learning techniques available. We tested Decision tree learning and Bayesian networks. The open source data-mining framework WEKA was the tool we used for testing the classify, cluster, association algorithms and for visualization of our results. The WEKA is a collection of machine learning algorithms for data mining tasks.

  7. Evaluation of fetal anomalies with MR imaging

    International Nuclear Information System (INIS)

    Twenty pregnant women underwent MR imaging (0.5 T) after US disclosed a significant fetal anomaly. The ability of MR imaging to depict the abnormalities was assessed. Of 20 abnormalities, 17 were visualized with MR imaging. Abnormalities included conjoined twins, omphalocele, gastroschisis, hydrocephalus, hydronephrosis, fetal ascites, facial teratoma, anencephaly, bladder outlet obstruction, thanatophoric dwarfism, cystic, hygroma, and fetal ovarian cyst. Thirteen of 14 abnormalities in third-trimester fetuses were visualized, as were four of six abnormalities in second-trimester fetuses. Associated polyhydramnios or oligohydramnios was evident in six of six cases. Anomalies were best delineated with T1-weighted sequences. The study suggests that MR imaging is potentially useful as a complementary imaging modality in the evaluation of fetal anomalies

  8. Anomaly mediation in local effective theories

    International Nuclear Information System (INIS)

    The phenomenon known as “anomaly mediation” can be understood in a variety of ways. Rather than an anomaly, certain gaugino bilinear terms are required by local supersymmetry and gauge invariance (the derivation of these terms is in some cases related to anomalies in scale invariance or R symmetries). We explain why the gaugino bilinear is required in supersymmetric gauge theories with varying number of colors and flavors. By working in the Higgs phase, gauging a flavor group, or working below the scale of gaugino condensation, each of these theories has a local effective description in which we can identify the bilinear term, establishing its necessity in the microscopic theory. For example, in theories that exhibit gaugino condensation, the potential in the very low energy theory is supersymmetric precisely due to the relation between the nonperturbative superpotential and the gaugino bilinear terms. Similarly, the gravitino mass appears from its coupling to the gaugino bilinear

  9. Weyl Anomaly and Initial Singularity Crossing

    CERN Document Server

    Awad, Adel

    2015-01-01

    We consider the role of quantum effects, mainly, Weyl anomaly in modifying FLRW model singular behavior at early times. Weyl anomaly corrections to FLRW models have been considered in the past, here we reconsider this model and show the following: The singularity of this model is weak according to Tipler and Krolak, therefore, the spacetime might admit a geodesic extension. Weyl anomaly corrections changes the nature of the initial singularity from a big bang singularity to a sudden singularity. The two branches of solutions consistent with the semiclassical treatment form a disconnected manifold. Joining these two parts at the singularity provides us with a $C^1$ extension to nonspacelike geodesics and leaves the spacetime geodesically complete. Using Gauss-Codazzi equations one can derive generalized junction conditions for this higher-derivative gravity. The extended spacetime obeys Friedmann and Raychaudhuri equations and the junction conditions. The junction does not generate Dirac delta functions in mat...

  10. Gauge Anomalies and Neutrino Seesaw Models

    CERN Document Server

    Neves Cebola, Luis Manuel

    Despite the success of the Standard Model concerning theoretical predictions, there are several experimental results that cannot be explained and there are reasons to believe that there exists new physics beyond it. Neutrino oscillations, and hence their masses, are examples of this. Experimentally it is known that neutrinos masses are quite small, when compared to all Standard Model particle masses. Among the theoretical possibilities to explain these tiny masses, the seesaw mechanism is a simple and well-motivated framework. In its minimal version, heavy particles are introduced that decouple from the theory in the early universe. To build consistent theories, classical symmetries need to be preserved at quantum level, so that there are no anomalies. The cancellation of these anomalies leads to constraints in the parameters of the theory. One attractive solution is to realize the anomaly cancellation through the modication of the gauge symmetry. In this thesis we present a short review of some features of t...

  11. Detect Adjacent Well by Analyzing Geomagnetic Anomalies

    Directory of Open Access Journals (Sweden)

    Su Zhang

    2014-03-01

    Full Text Available This study describes a method of determining the position of adjacent well by analyzing geomagnetic anomalies in the drilling. In the experiment, put a casing in the geomagnetic field respectively to simulate 3 conditions, which are vertical well, deviated well and horizontal well. Study the interference of regional geomagnetic caused by casing, summary the law of the regional geomagnetic field anomalies caused by the adjacent casing. Experimental results show that: magnetic intensity distortion caused by deviated well is similar to that caused by horizontal well, but the distortion is different from vertical well. The scope and amplitude of N and E component magnetic intensity distortion will increase with the increase of casing inclination, meanwhile the scope and amplitude of V component distortion will decrease and the distortion value changes from negative to positive to the southwest of adjacent well. Through the analysis of geomagnetic anomalies, the position of the adjacent wells could be determined.

  12. Holographic entanglement entropy and gravitational anomalies

    CERN Document Server

    Castro, Alejandra; Iqbal, Nabil; Perlmutter, Eric

    2014-01-01

    We study entanglement entropy in two-dimensional conformal field theories with a gravitational anomaly. In theories with gravity duals, this anomaly is holographically represented by a gravitational Chern-Simons term in the bulk action. We show that the anomaly broadens the Ryu-Takayanagi minimal worldline into a ribbon, and that the anomalous contribution to the CFT entanglement entropy is given by the twist in this ribbon. The entanglement functional may also be interpreted as the worldline action for a spinning particle -- that is, an anyon -- in three-dimensional curved spacetime. We demonstrate that the minimization of this action results in the Mathisson-Papapetrou-Dixon equations of motion for a spinning particle in three dimensions. We work out several simple examples and demonstrate agreement with CFT calculations.

  13. How to quantify structural anomalies in fluids?

    Science.gov (United States)

    Fomin, Yu D; Ryzhov, V N; Klumov, B A; Tsiok, E N

    2014-07-21

    Some fluids are known to behave anomalously. The so-called structural anomaly which means that the fluid becomes less structures under isothermal compression is among the most frequently discussed ones. Several methods for quantifying the degree of structural order are described in the literature and are used for calculating the region of structural anomaly. It is generally thought that all of the structural order determinations yield qualitatively identical results. However, no explicit comparison was made. This paper presents such a comparison for the first time. The results of some definitions are shown to contradict the intuitive notion of a fluid. On the basis of this comparison, we show that the region of structural anomaly can be most reliably determined from the behavior of the excess entropy. PMID:25053327

  14. Detecting data anomalies methods in distributed systems

    Science.gov (United States)

    Mosiej, Lukasz

    2009-06-01

    Distributed systems became most popular systems in big companies. Nowadays many telecommunications companies want to hold large volumes of data about all customers. Obviously, those data cannot be stored in single database because of many technical difficulties, such as data access efficiency, security reasons, etc. On the other hand there is no need to hold all data in one place, because companies already have dedicated systems to perform specific tasks. In the distributed systems there is a redundancy of data and each system holds only interesting data in appropriate form. Data updated in one system should be also updated in the rest of systems, which hold that data. There are technical problems to update those data in all systems in transactional way. This article is about data anomalies in distributed systems. Avail data anomalies detection methods are shown. Furthermore, a new initial concept of new data anomalies detection methods is described on the last section.

  15. Continental magnetic anomaly constraints on continental reconstruction

    Science.gov (United States)

    Vonfrese, R. R. B.; Hinze, W. J.; Olivier, R.; Bentley, C. R.

    1985-01-01

    Crustal magnetic anomalies mapped by the MAGSAT satellite for North and South America, Europe, Africa, India, Australia and Antarctica and adjacent marine areas were adjusted to a common elevation of 400 km and differentially reduced to the radial pole of intensity 60,000 nT. These radially polarized anomalies are normalized for differential inclination, declination and intensity effects of the geomagnetic field, so that in principle they directly reflected the geometric and magnetic polarization attributes of sources which include regional petrologic variations of the crust and upper mantle, and crustal thickness and thermal perturbations. Continental anomalies demonstrate remarkably detailed correlation of regional magnetic sources across rifted margins when plotted on a reconstruction of Pangea. Accordingly, they suggest further fundamental constraints on the geologic evolution of the continents and their reconstructions.

  16. The mineralogy of global magnetic anomalies

    Science.gov (United States)

    Haggerty, S. E. (Principal Investigator)

    1984-01-01

    Experimental and analytical data on magnetic mineralogy was provided as an aid to the interpretation of magnetic anomaly maps. An integrated program, ranging from the chemistry of materials from 100 or more km depth within the Earth, to an examination of the MAGSAT anomaly maps at about 400 km above the Earth's surface, was undertaken. Within this framework, a detailed picture of the pertinent mineralogical and magnetic relationships for the region of West Africa was provided. Efforts were directed toward: (1) examining the geochemistry, mineralogy, magnetic properties, and phases relations of magnetic oxides and metal alloys in rocks demonstrated to have originated in the lower crust of upper mantle, (2) examining the assumption that these rocks portray the nature of their source regions; and (3) examining the regional geology, tectonics, gravity field and the MAGSAT anomaly maps for West Africa.

  17. Anomaly cancellation condition in lattice gauge theory

    International Nuclear Information System (INIS)

    We show that, to all orders of powers of the gauge potential, a gauge anomaly Α defined on 4-dimensional infinite lattice can always be removed by a local counterterm, provided that Α depends smoothly and locally on the gauge potential and that Α reproduces the gauge anomaly in the continuum theory in the classical continuum limit: The unique exception is proportional to the anomaly in the continuum theory. This follows from an analysis of nontrivial local solutions to the Wess-Zumino consistency condition in lattice gauge theory. Our result is applicable to the lattice chiral gauge theory based on the Ginsparg-Wilson Dirac operator, when the gauge field is sufficiently weak parallel-U(n,μ) - 1-parallel < ε', where U(n,μ) is the link variable and ε' a certain small positive constant. (author)

  18. MR imaging of fetal cerebral anomalies

    International Nuclear Information System (INIS)

    Background. Prenatal diagnosis of fetal brain anomalies relies mainly upon ultrasonography. However, even in the most experienced hands, the technique has limitations for some difficult diagnoses. MRI is an excellent imaging modality for the paediatric and adult brain. Objective. To assess the value of prenatal MRI when a cerebral anomaly was detected by US and where the prognosis depended on the identification of other anomalies undetectable by US, or where fetuses were at risk for a CNS lesion even when the US was normal. Materials and methods. Four hundred prenatal MRI examinations were performed since 1988, and confirmed by postnatal follow-up or pathological examination. Two-thirds of the examinations were performed after 25 weeks of gestation, one-third between 21 and 26 weeks. Fetal immobilisation was obtained by maternal premedication with flunitrazepam, administered orally 1 h before the examination. The examinations were performed on 1.5 T scanners using one or two surface coils. Results. Prenatal MRI allowed the diagnosis of serious unsuspected lesions such as neuronal migration disorders, ischaemic and haemorrhagic lesions and the abnormalities observed in tuberous sclerosis. It helped to characterise ventricular dilatation and anomalies of the corpus callosum and of the posterior fossa. Conclusions. MRI is a valuable complementary tool when prenatal US is incomplete, doubtful or limited. Prenatal MRI is particularly useful for the detection of ischaemic and haemorrhagic lesions, neuronal migration disorders and tuberous sclerosis lesions. Detection of these associated anomalies worsens the fetal prognosis, has medico-legal implications and modifies obstetric management. Normal prenatal MRI does not exclude an anomaly. (orig.)

  19. MR imaging of fetal cerebral anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Sonigo, P.C.; Carteret, M.; Brunelle, F.O. [Department of Radiology, Hopital Des Enfants Malades, Paris (France); Rypens, F.F. [Department of Radiology, Hopital Des Enfants Malades, Paris (France)]|[Department of Radiology, Hopital Erasme, Brussels (Belgium); Delezoide, A.L. [Department of Pathology, Hopital Des Enfants Malades, Paris (France)

    1998-04-01

    Background. Prenatal diagnosis of fetal brain anomalies relies mainly upon ultrasonography. However, even in the most experienced hands, the technique has limitations for some difficult diagnoses. MRI is an excellent imaging modality for the paediatric and adult brain. Objective. To assess the value of prenatal MRI when a cerebral anomaly was detected by US and where the prognosis depended on the identification of other anomalies undetectable by US, or where fetuses were at risk for a CNS lesion even when the US was normal. Materials and methods. Four hundred prenatal MRI examinations were performed since 1988, and confirmed by postnatal follow-up or pathological examination. Two-thirds of the examinations were performed after 25 weeks of gestation, one-third between 21 and 26 weeks. Fetal immobilisation was obtained by maternal premedication with flunitrazepam, administered orally 1 h before the examination. The examinations were performed on 1.5 T scanners using one or two surface coils. Results. Prenatal MRI allowed the diagnosis of serious unsuspected lesions such as neuronal migration disorders, ischaemic and haemorrhagic lesions and the abnormalities observed in tuberous sclerosis. It helped to characterise ventricular dilatation and anomalies of the corpus callosum and of the posterior fossa. Conclusions. MRI is a valuable complementary tool when prenatal US is incomplete, doubtful or limited. Prenatal MRI is particularly useful for the detection of ischaemic and haemorrhagic lesions, neuronal migration disorders and tuberous sclerosis lesions. Detection of these associated anomalies worsens the fetal prognosis, has medico-legal implications and modifies obstetric management. Normal prenatal MRI does not exclude an anomaly. (orig.) With 19 figs., 33 refs.

  20. Minor physical anomalies in Tourette syndrome

    Directory of Open Access Journals (Sweden)

    Györgyi Csábi

    2008-09-01

    Full Text Available Background and Objectives: The prevalence of minor physical anomalies (prenatal errors of morphogenesis was evaluated in patients with Tourette syndrome to get indirect data on the possible role of aberrant neurodevelopment in the aetiology of Tourette syndrome. No published study is known on the minor physical anomaly prevalence in this recently intensively investigated disorder, and connecting to current opinions on a possible role of aberrant neurodevelopment in Tourette syndrome it seems important to introduce trait marker research focusing on brain maldevelopment. Methods: A scale developed by Méhes1,2 was used to detect the presence or absence of 57 minor physical anomalies in 24 patients with Tourette syndrome and in 24 matched controls 21 boys and 3 girls were evaluated, the age of onset of illness among the Tourette patients was between the age of 5 and 13. Results: The mean value of all minor physical anomalies was significantly higher among the group of patients compared with controls. (Mann - Whitney U - value: 49, 50, -Z = - 4,92, p = 0,001 In the case of 7 minor physical anomalies we could demonstrate statistically significant differences between the Tourette and the control sample. In the case of 4 minor malformations (supernumary nipples, prominent forehead, tongue with smooth and rough spots, double posterior hair whorl and of 3 phenogenetic variants (antimongoloid slant, inner epicanthic folds, high arched palate a significantly higher frequency was observed compared with control individuals. However after Bonferroni correction for the Fisher’s Exact test, only double posterior hair whorl and high arched palate showed a significantly higher frequency compared to control children (p = 0.001. Conclusions: The overrepresentation of minor physical anomalies in Tourette syndrome can strongly support the view that this disorder is related to pathological factors operating early in development.

  1. Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy

    Directory of Open Access Journals (Sweden)

    Kandadi Machender R

    2012-11-01

    Full Text Available Abstract Background Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardiac anomalies remain unknown. This study was designed to evaluate the impact of antioxidant enzyme catalase in anthrax lethal toxin-induced cardiomyocyte contractile dysfunction. Methods Wild type (WT and cardiac-specific catalase overexpression mice were challenged with lethal toxin (2 μg/g, intraperotineally (i.p.. Cardiomyocyte contractile and intracellular Ca2+ properties were assessed 18 h later using an IonOptix edge-detection system. Proteasome function was assessed using chymotrypsin-like and caspase-like activities. GFP-LC3 puncta and Western blot analysis were used to evaluate autophagy and protein ubiquitination. Results Lethal toxin exposure suppressed cardiomyocyte contractile function (suppressed peak shortening, maximal velocity of shortening/re-lengthening, prolonged duration of shortening/re-lengthening, and impaired intracellular Ca2+ handling, the effects of which were alleviated by catalase. In addition, lethal toxin triggered autophagy, mitochondrial and ubiquitin-proteasome defects, the effects of which were mitigated by catalase. Pretreatment of cardiomyocytes from catalase mice with the autophagy inducer rapamycin significantly attenuated or ablated catalase-offered protection against lethal toxin-induced cardiomyocyte dysfunction. On the other hand, the autophagy inhibitor 3-MA ablated or significantly attenuated lethal toxin-induced cardiomyocyte contractile anomalies. Conclusions Our results suggest that catalase is protective against anthrax lethal toxin-induced cardiomyocyte contractile and intracellular Ca2+ anomalies, possibly through regulation of autophagy and mitochondrial function.

  2. Distribution of branchial anomalies in a paediatric Asian population

    Science.gov (United States)

    Teo, Neville Wei Yang; Ibrahim, Shahrul Izham; Tan, Kun Kiaang Henry

    2015-01-01

    INTRODUCTION The objective of the present study was to review the distribution and incidence of branchial anomalies in an Asian paediatric population and highlight the challenges involved in the diagnosis of branchial anomalies. METHODS This was a retrospective chart review of all paediatric patients who underwent surgery for branchial anomalies in a tertiary paediatric hospital from August 2007 to November 2012. The clinical notes were correlated with preoperative radiological investigations, intraoperative findings and histology results. Branchial anomalies were classified based on the results of the review. RESULTS A total of 28 children underwent surgery for 30 branchial anomalies during the review period. Two children had bilateral branchial anomalies requiring excision. Of the 30 branchial anomalies, 7 (23.3%) were first branchial anomalies, 5 (16.7%) were second branchial anomalies, 3 (10.0%) were third branchial anomalies, and 4 (13.3%) were fourth branchial anomalies (one of the four patients with fourth branchial anomalies had bilateral branchial anomalies). In addition, seven children had 8 (26.7%) branchial anomalies that were thought to originate from the pyriform sinus; however, we were unable to determine if these anomalies were from the third or fourth branchial arches. There was inadequate information on the remaining 3 (10.0%) branchial anomalies for classification. CONCLUSION The incidence of second branchial anomalies appears to be lower in our Asian paediatric population, while that of third and fourth branchial anomalies was higher. Knowledge of embryology and the related anatomy of the branchial apparatus is crucial in the identification of the type of branchial anomaly. PMID:25917471

  3. Modeling And Detecting Anomalies In Scada Systems

    Science.gov (United States)

    Svendsen, Nils; Wolthusen, Stephen

    The detection of attacks and intrusions based on anomalies is hampered by the limits of specificity underlying the detection techniques. However, in the case of many critical infrastructure systems, domain-specific knowledge and models can impose constraints that potentially reduce error rates. At the same time, attackers can use their knowledge of system behavior to mask their manipulations, causing adverse effects to observed only after a significant period of time. This paper describes elementary statistical techniques that can be applied to detect anomalies in critical infrastructure networks. A SCADA system employed in liquefied natural gas (LNG) production is used as a case study.

  4. Comparing corrective actions with anomaly resolution

    International Nuclear Information System (INIS)

    Quality control and assurance are essential to any system to safeguard nuclear materials. Formalization of quality assurance activities for safeguards under the name of quality assurance has begun at several organizations. The approach to quality assurance for safeguards differs from quality assurance for facilities and hardware both in the definition and use of the product, which is information. Anomaly resolution is comparable to corrective actions in quality assurance of a hardware product, but is also part of the product of safeguards and, therefore, has its own quality assurance. This paper reviews corrective actions as compared to anomaly resolution

  5. Radioactive anomaly discrimination from spectral ratios

    Science.gov (United States)

    Maniscalco, James; Sjoden, Glenn; Chapman, Mac Clements

    2013-08-20

    A method for discriminating a radioactive anomaly from naturally occurring radioactive materials includes detecting a first number of gamma photons having energies in a first range of energy values within a predetermined period of time and detecting a second number of gamma photons having energies in a second range of energy values within the predetermined period of time. The method further includes determining, in a controller, a ratio of the first number of gamma photons having energies in the first range and the second number of gamma photons having energies in the second range, and determining that a radioactive anomaly is present when the ratio exceeds a threshold value.

  6. The GSI Time Anomaly: Facts and Fiction

    CERN Document Server

    Giunti, Carlo

    2009-01-01

    The claims that the GSI time anomaly is due to the mixing of neutrinos in the final state of the observed electron-capture decays of hydrogen-like heavy ions are refuted with the help of an analogy with a double-slit experiment. It is a consequence of causality. It is shown that the GSI time anomaly may be caused by quantum beats due to the existence of two coherent energy levels of the decaying ion with an extremely small energy splitting (about $6\\times10^{-16} \\text{eV}$) and relative probabilities having a ratio of about 1/99.

  7. Global Worldsheet Anomalies from M-Theory

    CERN Document Server

    Sparks, J

    2004-01-01

    We present an M-theory proof of the anomaly of Freed and Witten which in general shifts the quantisation law for the U(1) gauge field on a D6-brane. The derivation requires an understanding of how fields on the D6-brane lift to M-theory, together with a localisation formula which we prove using a U(1)-index theorem. We also show how the anomaly is related to the K-theory classification of Ramond-Ramond fields. In addition we discuss the M-theory origin of the D6-brane effective action, and illustrate the general arguments with a concrete example.

  8. Purley four-dimensional viable anomaly mediation

    International Nuclear Information System (INIS)

    Anomaly mediation of supersymmetry breaking solves the supersymmetric flavor problem thanks to its ultraviolet-insensitivity. However, it suffers from two problems: sleptons have negative masses-squared, and there are likely bulk moduli that spoil the framework. Here, we present the first fully ultraviolet-insensitive model of anomaly mediation with positive slepton masses-squared in a purely four-dimensional framework. Our model is based on the additional D-term contributions to the sparticle masses, and the conformal sequestering mechanism. (author)

  9. Singlet deflected anomaly/gauge mediation

    International Nuclear Information System (INIS)

    We study an extension of the standard anomaly/gauge mediation scenario where the messenger fields have direct interactions with an extra gauge singlet. This realizes a phenomenologically viable NMSSM-like scenario free of the μ-bμ problem. Current cosmological constraints imply a small size for the anomaly-mediation contributions, unless some source of R-parity violation is permitted. In the latter case the allowed regions in the parameter space can be substantially larger than in the corresponding gauge-mediation scenario.

  10. Congenital anomalies after assisted reproductive technology

    DEFF Research Database (Denmark)

    Pinborg, Anja; Henningsen, Anna-Karina Aaris; Malchau, Sara Sofie;

    2013-01-01

    Worldwide, more than 5 million children have been born after assisted reproductive technology (ART), and in many developed countries ART infants represent more than 1% of the birth cohorts. It is well known that ART children are at increased risk of congenital malformations even after adjustment...... literature on the association between ART and congenital anomalies with respect to subfertility, fertility treatment other than ART, and different ART methods including intracytoplasmic sperm injection, blastocyst culture, and cryotechniques. Trends over time in ART and congenital anomalies will also be...

  11. Interpretations of the ATLAS diboson anomaly

    Directory of Open Access Journals (Sweden)

    Kingman Cheung

    2015-12-01

    Full Text Available Recently, the ATLAS Collaboration recorded an interesting anomaly in diboson production with excesses at the diboson invariant mass around 2 TeV in boosted jets of all the WZ, W+W−, and ZZ channels. We offer a theoretical interpretation of the anomaly using a phenomenological right-handed model with extra W′ and Z′ bosons. Constraints from narrow total decay widths, dijet cross sections, and W/Z+H production are taken into account. We also comment on a few other possibilities.

  12. On SU(2) anomaly and Majorana fermions

    OpenAIRE

    Patrascu, Andrei

    2014-01-01

    In this paper a loophole in the SU(2) gauge anomaly is presented. It is shown that using several topological tools a theory can be designed that implements the quantization of a single Weyl doublet anomaly free while keeping the non-abelian character of the particle in the theory. This opens the perspective for non-Abelian statistics of deconfined particle like objects in 3+1 dimensions and for applications in Quantum Computing. Moreover, if this loophole cannot be closed, old arguments relat...

  13. Anomaly Detection using Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Dharminder Kumar, Suman , Nutan

    2013-07-01

    Full Text Available Support vector machine are among the most well known supervised anomaly detection technique, which are very efficient in handling large and high dimensional dataset. SVM, a powerful machine method developed from statistical learning and has made significant achievement in some field. This Technique does not suffer the limitations of data dimensionality and limited samples. In this present study, We can apply it to different domains of anomaly detection. Support vectors, which are critical for classification, are obtained by learning from the training samples. Results of SVM achieved high Accuracy and low false positive rate. Theoretically we compared our approach with neural network and clustering technique

  14. Fetal Kidney Anomalies: Next Generation Sequencing

    DEFF Research Database (Denmark)

    Rasmussen, Maria; Sunde, Lone; Nielsen, Marlene Louise;

    undergone postmortem examination. The approximately 110 genes included in the targeted panel were chosen on the basis of their potential involvement in embryonic kidney development, cystic kidney disease, or the renin-angiotensin system. DNA was extracted from fetal tissue samples or cultured chorion villus...... the nephronophthisis associated gene, TMEM67 and six fetuses had mutations in kidney developmental genes. For these fetuses kidney histology is presented. Conclusion and Perspectives In eight (14%) fetuses we identified a likely genetic cause of the kidney anomalies. Ten fetuses from eight families......, in which no mutations were identified, have been selected for exome sequencing in order to uncover novel genes associated to fetal kidney anomalies....

  15. Multifactor Explanations of Asset Pricing Anomalies.

    OpenAIRE

    Fama, Eugene F.; French, Kenneth R.

    1996-01-01

    Previous work shows that average returns on common stocks are related to firm characteristics like size, earnings/price, cash flow/price, book-to-market equity, past sales growth, long-term past return, and short-term past return. Because these patterns in average returns apparently are not explained by the capital asset pricing model, (CAPM), they are called anomalies. The authors find that, except for the continuation of short-term returns, the anomalies largely disappear in a three-factor ...

  16. Double chamber right ventricle in Williams syndrome: a rare cardiac anomaly reported.

    Science.gov (United States)

    Mazumdar, Jayitri; Sarkar, Rakesh; Badveli, Anusha; Majumder, Biswajit

    2016-01-01

    Cardiovascular abnormality is the most consistent finding and occur in almost 80 % of all Williams syndrome (WS). Although a number of cardiovascular defects are common to WS, the majority presents in some form of arterial stenosis whereas supravalvular aortic stenosis is the most common one. Here we describe a 12 year old boy with elfin facies, presenting with urinary incontinence and a systolic murmur in right upper parasternal region. Echocardiography showed presence of double chambered right ventricle (DCRV) along with supravalvular aortic stenosis (SVAS) and coronary artery aneurysms, left pulmonary artery stenosis and multiple bladder diverticula in CT abdomen. With the clinical suspicion the diagnosis of WS was made and confirmed by fluorescent in situ hybridisation (FISH) study showing deletion in 7q11.23. Though different forms of arterial stenosis at multiple sites have been demonstrated in WS, DCRV in Williams syndrome is not reported till date in medical literature. PMID:27006883

  17. Cardiac potassium channel subtypes

    DEFF Research Database (Denmark)

    Schmitt, Nicole; Grunnet, Morten; Olesen, Søren-Peter

    2014-01-01

    About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K(+) channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K(+) channels...... drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization reserve is supplemented by the fairly atrial-specific KV1.5, Kir3, KCa, and K2P channels. The role of the latter two subtypes in atria is currently being clarified, and several findings indicate that...... they could constitute targets for new pharmacological treatment of atrial fibrillation. The interplay between the different K(+) channel subtypes in both atria and ventricle is dynamic, and a significant up- and downregulation occurs in disease states such as atrial fibrillation or heart failure. The...

  18. Trends in Cardiac Pacemaker Batteries

    Directory of Open Access Journals (Sweden)

    Venkateswara Sarma Mallela

    2004-10-01

    Full Text Available Batteries used in Implantable cardiac pacemakers-present unique challenges to their developers and manufacturers in terms of high levels of safety and reliability. In addition, the batteries must have longevity to avoid frequent replacements. Technological advances in leads/electrodes have reduced energy requirements by two orders of magnitude. Micro-electronics advances sharply reduce internal current drain concurrently decreasing size and increasing functionality, reliability, and longevity. It is reported that about 600,000 pacemakers are implanted each year worldwide and the total number of people with various types of implanted pacemaker has already crossed 3 million. A cardiac pacemaker uses half of its battery power for cardiac stimulation and the other half for housekeeping tasks such as monitoring and data logging. The first implanted cardiac pacemaker used nickel-cadmium rechargeable battery, later on zinc-mercury battery was developed and used which lasted for over 2 years. Lithium iodine battery invented and used by Wilson Greatbatch and his team in 1972 made the real impact to implantable cardiac pacemakers. This battery lasts for about 10 years and even today is the power source for many manufacturers of cardiac pacemakers. This paper briefly reviews various developments of battery technologies since the inception of cardiac pacemaker and presents the alternative to lithium iodine battery for the near future.

  19. Platelets and cardiac arrhythmia

    Directory of Open Access Journals (Sweden)

    JonasSDe Jong

    2010-12-01

    Full Text Available Sudden cardiac death remains one of the most prevalent modes of death in industrialized countries, and myocardial ischemia due to thrombotic coronary occlusion is its primary cause. The role of platelets in the occurrence of SCD extends beyond coronary flow impairment by clot formation. Here we review the substances released by platelets during clot formation and their arrhythmic properties. Platelet products are released from three types of platelet granules: dense core granules, alpha-granules, and platelet lysosomes. The physiologic properties of dense granule products are of special interest as a potential source of arrhythmic substances. They are released readily upon activation and contain high concentrations of serotonin, histamine, purines, pyrimidines, and ions such as calcium and magnesium. Potential arrhythmic mechanisms of these substances, e.g. serotonin and high energy phosphates, include induction of coronary constriction, calcium overloading, and induction of delayed after-depolarizations. Alpha-granules produce thromboxanes and other arachidonic acid products with many potential arrhythmic effects mediated by interference with cardiac sodium, calcium and potassium channels. Alpha-granules also contain hundreds of proteins that could potentially serve as ligands to receptors on cardiomyocytes. Lysosomal products probably do not have an important arrhythmic effect. Platelet products and ischemia can induce coronary permeability, thereby enhancing interaction with surrounding cardiomyocytes. Antiplatelet therapy is known to improve survival after myocardial infarction. Although an important part of this effect results from prevention of coronary clot formation, there is evidence to suggest that antiplatelet therapy also induces anti-arrhythmic effects during ischemia by preventing the release of platelet activation products.

  20. Fourier analysis of multi-gated cardiac blood-pool data in patients with congenital heart diseases, (2)

    International Nuclear Information System (INIS)

    The clinical usefulness of Fourier analysis of multi-gated cardiac blood-pool data was evaluated in 18 subjects with normal cardiac functions and 14 patients with complex cardiac anomalies (ten with tetralogy of Fallot, two with tricuspid atresia (TA), one with double-outlet right ventricle (DORV), and one with Ebstein's anomaly (EA)). Using global ventricular time-activity curves, the phase and amplitude at fundamental frequency were calculated, and emptying patterns of the left and right ventricles (LV, RV) were evaluated by phase difference [D(phase)=RV phase minus LV phase] and amplitude ratio of RV to LV [R(amp)]. In patients with TOF, mean values of D (phase) and R(amp) were 25.3+-10.5 degrees and 13.5+-0.49 respectively and significantly larger than those of normal subjects (p<0.001). D (phase) became larger in inverse proportion to the ratio of pulmonary-to-systemic blood flow and there was an inverse linear correlation between these two variables (r=-0.830, p<0.01). On visual interpretation of functional images, the dynamic property of hypoplastic ventricles could be easily estimated in patients with TA or DORV. In a case with EA, the atrialized RV was shown clearly as a hypokinetic, atrial phase area. This method is valuable for pathophysiologic investigation of diseases with complex cardiac anomalies. (author)

  1. Metoclopramide-induced cardiac arrest

    Directory of Open Access Journals (Sweden)

    Martha M. Rumore

    2011-11-01

    Full Text Available The authors report a case of cardiac arrest in a patient receiving intravenous (IV metoclopramide and review the pertinent literature. A 62-year-old morbidly obese female admitted for a gastric sleeve procedure, developed cardiac arrest within one minute of receiving metoclopramide 10 mg via slow intravenous (IV injection. Bradycardia at 4 beats/min immediately appeared, progressing rapidly to asystole. Chest compressions restored vital function. Electrocardiogram (ECG revealed ST depression indicative of myocardial injury. Following intubation, the patient was transferred to the intensive care unit. Various cardiac dysrrhythmias including supraventricular tachycardia (SVT associated with hypertension and atrial fibrillation occurred. Following IV esmolol and metoprolol, the patient reverted to normal sinus rhythm. Repeat ECGs revealed ST depression resolution without pre-admission changes. Metoclopramide is a non-specific dopamine receptor antagonist. Seven cases of cardiac arrest and one of sinus arrest with metoclopramide were found in the literature. The metoclopramide prescribing information does not list precautions or adverse drug reactions (ADRs related to cardiac arrest. The reaction is not dose related but may relate to the IV administration route. Coronary artery disease was the sole risk factor identified. According to Naranjo, the association was possible. Other reports of cardiac arrest, severe bradycardia, and SVT were reviewed. In one case, five separate IV doses of 10 mg metoclopramide were immediately followed by asystole repeatedly. The mechanism(s underlying metoclopramide’s cardiac arrest-inducing effects is unknown. Structural similarities to procainamide may play a role. In view of eight previous cases of cardiac arrest from metoclopramide having been reported, further elucidation of this ADR and patient monitoring is needed. Our report should alert clinicians to monitor patients and remain diligent in surveillance and

  2. Congenital anomalies of coronary arteries: Diagnosis with 64 slice multidetector CT

    International Nuclear Information System (INIS)

    Objective: Congenital coronary artery anomalies are generally incidental, uncommon and asymptomatic. Some can cause severe potentially life threatening symptoms. The common mode of studying the coronary arteries is Conventional Coronary Angiogram. ECG-gated-multidetector CT is a non invasive modality. The objective of our study was to identify rare congenital coronary artery anomalies and discuss their clinical significance. Material and methods: A total number of 900 MDCT coronary angiograms were carried out at our institution between the period of April 2006 and October 2010. Patients with coronary artery anomaly constituted the subject of study. Results: The incidence of anomalous anatomical origin and course of the coronary arteries in our study was 1.55%. Hemodynamical significance was seen in five patients. 3 cases of single coronary artery originating from right coronary sinus were seen. 1 case of anomalous left coronary artery arising from main pulmonary artery was seen. 4 cases of anomalous RCA arising from left aortic cusp, 6 cases of absent LMCA with separate origin of LAD and LCX were seen. Conclusion: Multidetector row CT is a noninvasive modality in cardiac imaging. It provides superior resolution of coronary tree and its variant. No projectional vascular overlap is seen. Various postprocessing techniques outclass catheter angiography imaging. Definition of ostia and proximal course of the coronary arteries by Multidetector CT is better than catheter angiography.

  3. 10q26.1 Microdeletion: Redefining the critical regions for microcephaly and genital anomalies.

    Science.gov (United States)

    Choucair, Nancy; Abou Ghoch, Joelle; Fawaz, Ali; Mégarbané, André; Chouery, Eliane

    2015-11-01

    Distal 10q deletion syndrome is a well-characterized chromosomal disorder consisting of neurodevelopmental impairment, facial dysmorphism, cardiac malformations, genital and urinary tract defects, as well as digital anomalies. Patients with interstitial deletions involving band 10q26.1 present a phenotype similar to the ones with the distal 10q deletion syndrome, which led to the definition of a causal 600 kb smallest region of overlap (SRO). In this report, we describe a male patient with an interstitial 4.5 Mb deletion involving exclusively the 10q26.1 segment. He had growth and psychomotor retardation, microcephaly, flat feet, micropenis, and cryptorchidism. The patient's deleted region does not overlap the 10q SRO. We reviewed the clinical phenotype of patients with similar deletions and suggest the presence of two new SROs, one associated with microcephaly, growth and psychomotor retardation, and the other associated to genital anomalies. Interestingly, we narrowed those regions to segments encompassing five and two genes, respectively. FGFR2, NSMCE4A, and ATE1 were suggested as candidates for facial dysmorphism, growth cessation, and heart defects, respectively. WDR11 was linked to idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Its haploinsufficiency could play a crucial role in the genital anomalies of these patients. PMID:26114870

  4. Cardiac perioperative complications in noncardiac surgery

    OpenAIRE

    Radovanović Dragana; Kolak Radmila; Stokić Aleksandar; Radovanović Zoran; Jovanović Gordana

    2008-01-01

    Anesthesiologists are confronted with an increasing population of patients undergoing noncardiac surgery who are at risk for cardiac complications in the perioperative period. Perioperative cardiac complications are responsible for significant mortality and morbidity. The aim of the present study was to determine the incidence of perioperative (operative and postoperative) cardiac complications and correlations between the incidence of perioperative cardiac complications and type of surgical ...

  5. Epigenetic regulation in cardiac fibrosis

    Institute of Scientific and Technical Information of China (English)

    Li-Ming; Yu; Yong; Xu

    2015-01-01

    Cardiac fibrosis represents an adoptive response in the heart exposed to various stress cues. While resolution of the fibrogenic response heralds normalization of heart function, persistent fibrogenesis is usually associated with progressive loss of heart function and eventually heart failure. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix proteins, a process the epigenetic machinery plays a pivotal role. In this minireview, we summarize recent advances regarding the epigenetic regulation of cardiac fibrosis focusing on the role of histone and DNA modifications and non-coding RNAs.

  6. Uterine didelphys with obstructed hemivagina and ipsilateral renal anomaly - OHVIRA syndrome: a rare congenital anomaly

    Directory of Open Access Journals (Sweden)

    Bhimarao Patil

    2015-06-01

    Full Text Available OHVIRA or Herlyn-Werner-Wunderlich syndrome is a rare congenital anomaly characterized by uterine anomaly with obstructed hemivagina and ipsilateral renal anomaly. We present a case of 16 year female who presented with cyclical lower abdominal pain. Ultrasonography and computed tomography in this patient revealed classic triad of findings. Our case is significant as the diagnosis was made at an earlier stage of the disease before development of gross obstruction and hematometrocolpos. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 889-892

  7. Axial anomaly of QED in a strong magnetic field and noncommutative anomaly

    OpenAIRE

    Sadooghi, N.; Salim, A. Jafari

    2006-01-01

    The Adler-Bell-Jackiw (ABJ) anomaly of a 3+1 dimensional QED is calculated in the presence of a strong magnetic field. It is shown that in the regime with the lowest Landau level (LLL) dominance a dimensional reduction from D=4 to D=2 dimensions occurs in the longitudinal sector of the low energy effective field theory. In the chiral limit, the resulting anomaly is therefore comparable with the axial anomaly of a two dimensional massless Schwinger model. It is further shown that the U(1) axia...

  8. Possible Waardenburg syndrome with gastrointestinal anomalies.

    OpenAIRE

    Nutman, J; Steinherz, R; Sivan, Y; Goodman, R M

    1986-01-01

    We describe a patient with possible Waardenburg syndrome associated with anal atresia and oesophageal atresia with tracheooesophageal fistula. Three other published cases with atretic gastrointestinal anomalies associated with the Waardenburg syndrome are reviewed. We conclude that the association between atretic lesions of the gastrointestinal tract and the Waardenburg syndrome may be a significant one.

  9. PROBLEMA ANOMALI DALAM INITIAL PUBLIC OFFERING (IPO

    Directory of Open Access Journals (Sweden)

    Sautma Ronni Basana

    2003-01-01

    Full Text Available This study on Initial Public Offerings (IPO showed that IPO stocks on average were underpriced, underperformed in the long run aftermarket and the Hot and Cold market cycle was present. These phenomenom can be explained by among others, the following: Asymetric Information, Winner's Curse, Traditional-Ibbotson, and Signalling Equilibrium Phenomenom. However, all of these can't give a satisfactory explanation because they were based on the price which existed on the secondary market (Underpriced Theory. The Withdrawn IPO (WIPO theory tried to explain the IPO anomaly differently so that the IPO anomaly could be explained clearly. Abstract in Bahasa Indonesia : Studi tentang Penawaran Saham Perdana (IPO menunjukkan saham-saham IPO secara rata-rata mengalami Underpriced, kinerja jangka panjang yang jelek dan adanya siklus pasar "Hot" dan "Cold". Ada beberapa penjelasan terhadap fenomena tersebut, antara lain: Informasi Asimetri, WinnerCurse, Tradisional-Ibbotson, Signaling Equilibrium Phenomenom tetapi semuanya belum memuaskan karena berdasarkan pada basis harga yang ada di pasar sekunder (Teori Underpriced. Teori Withdrawn IPO (WIPO mencoba menjelaskan fenomena anomali IPO dengan cara yang berbeda sehingga fenomena anomali IPO dapat dijelaskan secara tuntas. Kata kunci: Penawaran Saham Perdana (IPO, Underpriced, Withdrawn IPO (WIPO.

  10. Heineman Prize Lecture: Anomaly Cancellation: A Retrospective

    Science.gov (United States)

    Schwarz, John

    2002-04-01

    The mechanism by which gauge and gravitational anomalies cancel in certain string theories is reviewed. A few new tricks are introduced to make the derivation a little simpler, and the string-theoretic interpretation a little clearer, than in the original 1984 work.

  11. A Natural origin for the LHCb anomalies

    CERN Document Server

    Megias, Eugenio; Pujolas, Oriol; Quiros, Mariano

    2016-01-01

    The anomalies recently found by the LHCb collaboration in $B$-meson decays seem to point towards the existence of new physics coupled non-universally to muons and electrons. We show that a beyond-the-Standard-Model dynamics with these features naturally arises in models with a warped extra-dimension that aim to solve the electroweak Hierarchy Problem. The attractiveness of our set-up is the fact that the dynamics responsible for generating the flavor anomalies is automatically present, being provided by the massive Kaluza--Klein excitations of the electroweak gauge bosons. The flavor anomalies can be easily reproduced by assuming that the bottom and muon fields have a sizable amount of compositeness, while the electron is almost elementary. Interestingly enough, this framework correlates the flavor anomalies to a pattern of corrections in the electroweak observables and in flavor-changing processes. In particular the deviations in the bottom and muon couplings to the $Z$-boson and in $\\Delta F = 2$ flavor-cha...

  12. Analyzing Spatiotemporal Anomalies through Interactive Visualization

    Directory of Open Access Journals (Sweden)

    Tao Zhang

    2014-06-01

    Full Text Available As we move into the big data era, data grows not just in size, but also in complexity, containing a rich set of attributes, including location and time information, such as data from mobile devices (e.g., smart phones, natural disasters (e.g., earthquake and hurricane, epidemic spread, etc. We are motivated by the rising challenge and build a visualization tool for exploring generic spatiotemporal data, i.e., records containing time location information and numeric attribute values. Since the values often evolve over time and across geographic regions, we are particularly interested in detecting and analyzing the anomalous changes over time/space. Our analytic tool is based on geographic information system and is combined with spatiotemporal data mining algorithms, as well as various data visualization techniques, such as anomaly grids and anomaly bars superimposed on the map. We study how effective the tool may guide users to find potential anomalies through demonstrating and evaluating over publicly available spatiotemporal datasets. The tool for spatiotemporal anomaly analysis and visualization is useful in many domains, such as security investigation and monitoring, situation awareness, etc.

  13. Trace anomaly and counterterms in designer gravity

    Science.gov (United States)

    Anabalón, Andrés; Astefanesei, Dumitru; Choque, David; Martínez, Cristián

    2016-03-01

    We construct concrete counterterms of the Balasubramanian-Kraus type for Einstein-scalar theories with designer gravity boundary conditions in AdS4, so that the total action is finite on-shell and satisfy a well defined variational principle. We focus on scalar fields with the conformal mass m 2 = -2 l -2 and show that the holographic mass matches the Hamiltonian mass for any boundary conditions. We compute the trace anomaly of the dual field theory in the generic case, as well as when there exist logarithmic branches of non-linear origin. As expected, the anomaly vanishes for the boundary conditions that are AdS invariant. When the anomaly does not vanish, the dual stress tensor describes a thermal gas with an equation of state related to the boundary conditions of the scalar field. In the case of a vanishing anomaly, we recover the dual theory of a massless thermal gas. As an application of the formalism, we consider a general family of exact hairy black hole solutions that, for some particular values of the parameters in the moduli potential, contains solutions of four-dimensional gauged {N}=8 supergravity and its ω-deformation. Using the AdS/CFT duality dictionary, they correspond to triple trace deformations of the dual field theory.

  14. Conformal Anomaly and Counterterms in Designer Gravity

    CERN Document Server

    Anabalon, Andres; Choque, David; Martinez, Cristian

    2015-01-01

    We construct concrete counterterms of the Balasubramanian-Kraus type for Einstein-scalar theories with designer gravity boundary conditions in AdS$_{4}$, so that the total action is finite on-shell and satisfy a well defined variational principle for an arbitrary scalar field potential. We focus on scalar fields with the conformal mass, $m^{2}=-2l^{-2}$, and show that the holographic mass matches the Hamiltonian mass for any boundary conditions. We compute the conformal anomaly of the dual field theory in the generic case, as well as when there exist logarithmic branches of non-linear origin. As expected, the conformal anomaly vanishes for the boundary conditions that are AdS invariant. When the anomaly does not vanish, the dual stress tensor describes a thermal gas with an equation of state related to the boundary conditions of the scalar field. When the anomaly vanishes, we recover the dual theory of a massless thermal gas. As an application of the formalism, we consider a general family of exact hairy blac...

  15. Anomaly Detection using the "Isolation Forest" algorithm

    CERN Document Server

    CERN. Geneva

    2015-01-01

    Anomaly detection can provide clues about an outlying minority class in your data: hackers in a set of network events, fraudsters in a set of credit card transactions, or exotic particles in a set of high-energy collisions. In this talk, we analyze a real dataset of breast tissue biopsies, with malignant results forming the minority class. The "Isolation Forest" algorithm finds anomalies by deliberately “overfitting” models that memorize each data point. Since outliers have more empty space around them, they take fewer steps to memorize. Intuitively, a house in the country can be identified simply as “that house out by the farm”, while a house in the city needs a longer description like “that house in Brooklyn, near Prospect Park, on Union Street, between the firehouse and the library, not far from the French restaurant”. We first use anomaly detection to find outliers in the biopsy data, then apply traditional predictive modeling to discover rules that separate anomalies from normal data...

  16. Craniofacial bone anomalies in Von Recklinghausen's neurofibromatosis

    International Nuclear Information System (INIS)

    Cases of cranio-facial bone anomalies were observed in 40 cases of neurofibromatosis. The cranio-facial skeletal manifestations are numerous and varied. Radiographic investigation is important to confirm the diagnosis, when neurologic and cutaneous signs are absent. The diagnosis should be easily confirmed by a conventional radiographic study. (authors). 14 refs., 7 figs., 2 tabs

  17. Realistic anomaly mediation with bulk gauge fields

    International Nuclear Information System (INIS)

    We present a simple general framework for realistic models of supersymmetry breaking driven by anomaly mediation. We consider a 5-dimensional 'brane universe' where the visible and hidden sectors are localized on different branes, and the standard model gauge bosons propagate in the bulk. In this framework there can be charged scalar messengers that have contact interactions with the hidden sector, either localized in the hidden sector or in the bulk. These scalars obtain soft masses that feed into visible sector scalar masses at two loop order via bulk gauge interactions. This contribution is automatically flavor-blind, and can be naturally positive. If the messengers are in the bulk this contribution is automatically the same order of magnitude as the anomaly mediated contribution, independent of the brane spacing. If the messengers are localized to a brane the two effects are of the same order for relatively small brane spacings. The gaugino masses and A terms are determined completely by anomaly mediation. In order for anomaly mediation to dominate over radion mediation the radion must be is stabilized in a manner that preserves supersymmetry, with supergravity effects included. We show that this occurs in simple models. We also show that the mu problem can be solved by the vacuum expectation value of a singlet in this framework. (author)

  18. Alaska Terrain Corrected Free Air Anomalies (96)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 2' x 4' gravity anomaly grid for Alaska is NOT the input data set used in development of the GEOID96 model. This gravity grid models the 1.1 million...

  19. Seasonality of Congenital Anomalies in Europe

    NARCIS (Netherlands)

    Luteijn, Johannes Michiel; Dolk, Helen; Addor, Marie-Claude; Arriola, Larraitz; Barisic, Ingeborg; Bianchi, Fabrizio; Calzolari, Elisa; Draper, Elizabeth; Garne, Ester; Gatt, Miriam; Haeusler, Martin; Khoshnood, Babak; McDonnell, Bob; Nelen, Vera; O'Mahony, Mary; Mullaney, Carmel; Queisser-Luft, Annette; Rankin, Judith; Tucker, David; Verellen-Dumoulin, Christine; de Walle, Hermien; Yevtushok, Lyubov

    2014-01-01

    BackgroundThis study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to

  20. Detection of cardiovascular anomalies: Hybrid systems approach

    KAUST Repository

    Diaz Ledezma, Fernando

    2012-06-06

    In this paper, we propose a hybrid interpretation of the cardiovascular system. Based on a model proposed by Simaan et al. (2009), we study the problem of detecting cardiovascular anomalies that can be caused by variations in some physiological parameters, using an observerbased approach. We present the first numerical results obtained. © 2012 IFAC.

  1. Curious numerical coincidence to the Pioneer anomaly

    OpenAIRE

    Ivanescu, Liviu

    2009-01-01

    One noticed a pure numerical coincidence between the Pioneer spacecrafts deceleration anomaly and (gamma-1), with gamma the Lorentz factor. The match is not only for distances larger than 20 AU, but even for the observed slop between 10 and 20 AU.

  2. Praenatalt diagnosticeret hydronefrose og andre urologiske anomalier

    DEFF Research Database (Denmark)

    Cortes, Dina; Jørgensen, Troels Munch; Rittig, Søren; Thaarup, Jesper; Hansen, Anita; Andersen, Karen Vitting; Thorup, Jørgen Mogens; Jørgensen, Connie; Søgaard, Kirsten; Eskild-Jensen, Anni; Frøkiaer, Jørgen; Hørlyk, Arne; Jensen, Flemming

    fetal ultrasound examination of the kidneys and the urinary tract, about 70 children would be born each year with a prenatally diagnosed urological anomaly for which surgical procedure is or will be indicated. This paper provides Danish guidelines for prenatal diagnosis, follow-up and intervention in...

  3. Psychoeducational Implications of Sex Chromosome Anomalies

    Science.gov (United States)

    Wodrich, David L.; Tarbox, Jennifer

    2008-01-01

    Numerous anomalies involving the sex chromosomes (X or Y) have been documented and their impact on development, learning, and behavior studied. This article reviews three of these disorders, Turner syndrome, Klinefelter syndrome, and Lesch-Nyhan disease. Each of these three is associated with one or more selective impairments or behavioral…

  4. Table of hyperfine anomaly in atomic systems

    OpenAIRE

    Persson, Jonas R.

    2011-01-01

    This table is a compilation of experimental values of magnetic hyperfine anomaly in atomic and ionic systems. The last extensive compilation was published in 1984 by Buttgenbach (Hyperfine Interactions 20, (1984) p 1) and the aim here is to make an up to date compilation. The literature search covers the period to January 2011.

  5. Oxygen isotopic anomaly and solar nebular photochemistry

    International Nuclear Information System (INIS)

    At the cool periphery of the solar nebula, oxygen could photochemically be formed from water. The mixing of 17O and 18O enriched by the self-shielding effect of 16O2 to the dust grain melted by the shock waves there would explain the oxygen isotopic anomaly in the high-temperature mineral of the carbonaceous meteorites. (Auth.)

  6. Congenital spine anomalies: the closed spinal dysraphisms

    Energy Technology Data Exchange (ETDEWEB)

    Schwartz, Erin Simon [University of Pennsylvania, Department of Radiology, The Children' s Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, PA (United States); Rossi, Andrea [G. Gaslini Children' s Hospital, Department of Radiology, Genoa (Italy)

    2015-09-15

    The term congenital spinal anomalies encompasses a wide variety of dysmorphology that occurs during early development. Familiarity with current terminology and a practical, clinico-radiologic classification system allows the radiologist to have a more complete understanding of malformations of the spine and improves accuracy of diagnosis when these entities are encountered in practice. (orig.)

  7. Cardiac catheterization and angiography. Third edition

    International Nuclear Information System (INIS)

    This book discusses the papers on cardiac catheterization and angiography. The topics covered are: historical perspective and present practice of cardiac catheterization; angiography principles and utilization of radiologic and cineangiographic equipment; complications, incidence and prevention of side effects of cardiac catheterization; techniques; blood flow measurement of heart; pressure measurement; diagnostic techniques of angiography; special catheter techniques; coronary angiography, temporary and permanent pacemakers, potential role of lasers in the cardiac catheterization and evaluation of cardiac function

  8. Antifibrotic therapies to control cardiac fibrosis

    OpenAIRE

    Fan, Zhaobo; Guan, Jianjun

    2016-01-01

    Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis continuously expands the size of fibrotic tissue and causes cardiac function decrease. Cardiac fibrosis eventually evolves the infarcted hearts into heart failure. Inhibiting cardiac fibrosis from progressing is critical to prevent heart failure. However, there is no efficient therapeutic approach curren...

  9. Robotic Applications in Cardiac Surgery

    Directory of Open Access Journals (Sweden)

    Alan P. Kypson

    2008-11-01

    Full Text Available Traditionally, cardiac surgery has been performed through a median sternotomy, which allows the surgeon generous access to the heart and surrounding great vessels. As a paradigm shift in the size and location of incisions occurs in cardiac surgery, new methods have been developed to allow the surgeon the same amount of dexterity and accessibility to the heart in confined spaces and in a less invasive manner. Initially, long instruments without pivot points were used, however, more recent robotic telemanipulation systems have been applied that allow for improved dexterity, enabling the surgeon to perform cardiac surgery from a distance not previously possible. In this rapidly evolving field, we review the recent history and clinical results of using robotics in cardiac surgery.

  10. Cardiac manifestations in systemic sclerosis

    Institute of Scientific and Technical Information of China (English)

    Sevdalina; Lambova

    2014-01-01

    Primary cardiac involvement, which develops as a direct consequence of systemic sclerosis(SSc), may manifest as myocardial damage, fibrosis of the conduction system, pericardial and, less frequently, as valvular disease. In addition, cardiac complications in SSc may develop as a secondary phenomenon due to pulmonary arterial hypertension and kidney pathology. The prevalence of primary cardiac involvement in SSc is variable and difficult to determine because of the diversity of cardiac manifestations, the presence of subclinical periods, the type of diagnostic tools applied, and the diversity of patient populations. When clinically manifested, cardiac involvement is thought to be an important prognostic factor. Profound microvascular disease is a pathognomonic feature of SSc, as both vasospasm and structural alterations are present. Such alterations are thought to predict macrovascular atherosclerosis over time. There are contradictory reports regarding the prevalence of atherosclerosis in SSc. According to some authors, the prevalence of atherosclerosis of the large epicardial coronary arteries is similar to that of the general population, in contrast with other rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus. However, the level of inflammation in SSc is inferior. Thus, the atherosclerotic process may not be as aggressive and not easily detectable in smaller studies. Echocardiography(especially tissue Doppler imaging), single-photon emission computed tomography, magnetic resonance imaging and cardiac computed tomography are sensitive techniques for earlier detection of both structural and functional scleroderma-related cardiac pathologies. Screening for subclinical cardiac involvement via modern, sensitive tools provides an opportunity for early diagnosis and treatment, which is of crucial importance for a positive outcome.

  11. Computational Modeling of Cardiac Electromechanics

    OpenAIRE

    Krishnamoorthi, Shankarjee

    2013-01-01

    Cardiac arrhythmias are a leading cause of death worldwide. Notably, the electrophysiologiy and microstructural requirements for a fatal ventricular arrhythmia remain incompletely understood, thereby the treatment remains largely empirical. Standard antiarrhythmic drug therapy has failed to reduce, and in some instances has increased, the incidence of Sudden Cardiac Death (SCD). Hence, a more complete understanding of the mechanisms that foment a fatal arrhythmia is needed and computational m...

  12. Cardiac Biomarkers in Hyperthyroid Cats

    OpenAIRE

    Sangster, Jodi Kirsten

    2013-01-01

    Background: Hyperthyroidism has substantial effects on the circulatory system. The cardiac biomarkers NT-proBNP and troponin I (cTNI) have proven useful in identifying cats with myocardial disease but have not been as extensively investigated in hyperthyroidism.Hypothesis: Plasma NT-proBNP and cTNI concentrations are higher in cats with primary cardiac disease than in cats with hyperthyroidism and higher in cats with hyperthyroidism than in healthy control cats.Animals: Twenty-three hyperthyr...

  13. Current trends in cardiac rehabilitation

    OpenAIRE

    Dafoe, W; Huston, P

    1997-01-01

    Cardiac rehabilitation can reduce mortality and morbidity for patients with many types of cardiac disease cost-effectively, yet is generally underutilized. Rehabilitation is helpful not only for patients who have had a myocardial infarction but also for those with stable angina or congestive heart failure or those who have undergone myocardial revascularization procedures, a heart transplant or heart valve surgery. The beneficial effects of rehabilitation include a reduction in the rate of de...

  14. Gastrointestinal Complications and Cardiac Surgery

    OpenAIRE

    Allen, Sara J.

    2014-01-01

    Gastrointestinal (GI) complications are an uncommon but potentially devastating complication of cardiac surgery. The reported incidence varies between .3% and 5.5% with an associated mortality of .3–87%. A wide range of GI complications are reported with bleeding, mesenteric ischemia, pancreatitis, cholecystitis, and ileus the most common. Ischemia is thought to be the main cause of GI complications with hypoperfusion during cardiac surgery as well as systemic inflammation, hypothermia, drug ...

  15. Cardiac abnormalities after subarachnoid hemorrhage

    OpenAIRE

    Bilt, I.A.C. van der

    2016-01-01

    Aneurysmal subarachnoid hemorrhage(aSAH) is a devastating neurological disease. During the course of the aSAH several neurological and medical complications may occur. Cardiac abnormalities after aSAH are observed often and resemble stress cardiomyopathy or Tako-tsubo cardiomyopathy(Broken Heart Syndrome) that has been described after acute stress. It is a reversible cardiac dysfunction with distinct imaging features(the echocardiographic or left ventricular angiographic image resembles a Tak...

  16. Orbital debris hazard insights from spacecraft anomalies studies

    Science.gov (United States)

    McKnight, Darren S.

    2016-09-01

    Since the dawning of the space age space operators have been tallying spacecraft anomalies and failures then using these insights to improve the space systems and operations. As space systems improved and their lifetimes increased, the anomaly and failure modes have multiplied. Primary triggers for space anomalies and failures include design issues, space environmental effects, and satellite operations. Attempts to correlate anomalies to the orbital debris environment have started as early as the mid-1990's. Early attempts showed tens of anomalies correlated well to altitudes where the cataloged debris population was the highest. However, due to the complexity of tracing debris impacts to mission anomalies, these analyses were found to be insufficient to prove causation. After the fragmentation of the Chinese Feng-Yun satellite in 2007, it was hypothesized that the nontrackable fragments causing anomalies in LEO would have increased significantly from this event. As a result, debris-induced anomalies should have gone up measurably in the vicinity of this breakup. Again, the analysis provided some subtle evidence of debris-induced anomalies but it was not convincing. The continued difficulty in linking debris flux to satellite anomalies and failures prompted the creation of a series of spacecraft anomalies and failure workshops to investigate the identified shortfalls. These gatherings have produced insights into why this process is not straightforward. Summaries of these studies and workshops are presented and observations made about how to create solutions for anomaly attribution, especially as it relates to debris-induced spacecraft anomalies and failures.

  17. FGF21 and cardiac physiopathology

    Directory of Open Access Journals (Sweden)

    Anna ePlanavila

    2015-08-01

    Full Text Available The heart is not traditionally considered either a target or a site of fibroblast growth factor-21 (FGF21 production. However, recent findings indicate that FGF21 can act as a cardiomyokine; that is, it is produced by cardiac cells at significant levels and acts in an autocrine manner on the heart itself. The heart is sensitive to the effects of FGF21, both systemic and locally generated, owing to the expression in cardiomyocytes of β-Klotho, the key co-receptor known to confer specific responsiveness to FGF21 action. FGF21 has been demonstrated to protect against cardiac hypertrophy, cardiac inflammation, and oxidative stress. FGF21 expression in the heart is induced in response to cardiac insults, such as experimental cardiac hypertrophy and myocardial infarction in rodents, as well as in failing human hearts. Intracellular mechanisms involving PPARα and Sirt1 mediate transcriptional regulation of the FGF21 gene in response to exogenous stimuli. In humans, circulating FGF21 levels are elevated in coronary heart disease and atherosclerosis, and are associated with a higher risk of cardiovascular events in patients with type 2 diabetes. These findings provide new insights into the role of FGF21 in the heart and may offer potential therapeutic strategies for cardiac disease.

  18. Physiological and pathological cardiac hypertrophy.

    Science.gov (United States)

    Shimizu, Ippei; Minamino, Tohru

    2016-08-01

    The heart must continuously pump blood to supply the body with oxygen and nutrients. To maintain the high energy consumption required by this role, the heart is equipped with multiple complex biological systems that allow adaptation to changes of systemic demand. The processes of growth (hypertrophy), angiogenesis, and metabolic plasticity are critically involved in maintenance of cardiac homeostasis. Cardiac hypertrophy is classified as physiological when it is associated with normal cardiac function or as pathological when associated with cardiac dysfunction. Physiological hypertrophy of the heart occurs in response to normal growth of children or during pregnancy, as well as in athletes. In contrast, pathological hypertrophy is induced by factors such as prolonged and abnormal hemodynamic stress, due to hypertension, myocardial infarction etc. Pathological hypertrophy is associated with fibrosis, capillary rarefaction, increased production of pro-inflammatory cytokines, and cellular dysfunction (impairment of signaling, suppression of autophagy, and abnormal cardiomyocyte/non-cardiomyocyte interactions), as well as undesirable epigenetic changes, with these complex responses leading to maladaptive cardiac remodeling and heart failure. This review describes the key molecules and cellular responses involved in physiological/pathological cardiac hypertrophy. PMID:27262674

  19. Cardiac MRI in suspected myocarditis

    International Nuclear Information System (INIS)

    Purpose: To evaluate the potential of ECG-gated breath-hold MRI in diagnosing acute myocardidits. Material and methods: Cardiac MRI was performed on 21 consecutive patients with suspected myocarditis. ECG-gated breath-hold T2-weighted images with fat suppression were acquired in 3 standard views. T1-weighted imaging (FLASH) was performed 10 min after IV administration of Gd-DTPA. Laboratory data included creatine kinase, troponin T and serological tests, ECG findings and echocardiography. Imaging findings were retrospectively compared to the discharge diagnoses. Signal alterations were semiquantitatively classified. Results: Acute myocarditis was diagnosed in 9 patients and cardiac sarcoidosis in 2 patients. Late enhancement was observed in 4 patients with acute myocarditis and in both patients with cardiac sarcoidosis. Semiquantitative evaluation revealed 9 true positive, 9 true negative, 1 false positive and 2 false negative results. Conclusion: Cardiac MRI has the potential to detect acute myocarditis and to diagnose cardiac sarcoidosis. Late enhancement of Gd-DTPA can be found in both viral myocarditis and cardiac sarcoidosis. (orig.)

  20. Cardiac imaging. A multimodality approach

    International Nuclear Information System (INIS)

    An excellent atlas on modern diagnostic imaging of the heart Written by an interdisciplinary team of experts, Cardiac Imaging: A Multimodality Approach features an in-depth introduction to all current imaging modalities for the diagnostic assessment of the heart as well as a clinical overview of cardiac diseases and main indications for cardiac imaging. With a particular emphasis on CT and MRI, the first part of the atlas also covers conventional radiography, echocardiography, angiography and nuclear medicine imaging. Leading specialists demonstrate the latest advances in the field, and compare the strengths and weaknesses of each modality. The book's second part features clinical chapters on heart defects, endocarditis, coronary heart disease, cardiomyopathies, myocarditis, cardiac tumors, pericardial diseases, pulmonary vascular diseases, and diseases of the thoracic aorta. The authors address anatomy, pathophysiology, and clinical features, and evaluate the various diagnostic options. Key features: - Highly regarded experts in cardiology and radiology off er image-based teaching of the latest techniques - Readers learn how to decide which modality to use for which indication - Visually highlighted tables and essential points allow for easy navigation through the text - More than 600 outstanding images show up-to-date technology and current imaging protocols Cardiac Imaging: A Multimodality Approach is a must-have desk reference for cardiologists and radiologists in practice, as well as a study guide for residents in both fields. It will also appeal to cardiac surgeons, general practitioners, and medical physicists with a special interest in imaging of the heart. (orig.)