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Sample records for antiqua andnepal516 evidence

  1. Complete Genome Sequence of Yersinia pestis Strains Antiqua andNepal516: Evidence of Gene Reduction in an Emerging Pathogen

    Energy Technology Data Exchange (ETDEWEB)

    Chain, Patrick S.G.; Hu, Ping; Malfatti, Stephanie A.; Radnedge,Lyndsay; Larimer, Frank; Vergez, Lisa M.; Worsham, Patricia; Chu, May C.; Andersen, Gary L.

    2006-01-16

    Yersinia pestis, the causative agent of bubonic andpneumonicplague, has undergone detailed study at the molecular level. Tofurther investigate the genomic diversity among this group and to helpcharacterize lineages of the plague organism that have no sequencedmembers, we present here the genomes of two isolates of the "classical"Antiqua biovar, strains Antiqua and Nepal516. The genomes of Antiqua andNepal516 are 4.7 Mb and 4.5 Mb and encode 4,138 and 3,956 open readingframes respectively. Though both strains belong to one of the threeclassical biovars, they represent separate lineages defined by recentphylogenetic studies. We compare all five currently sequenced Y. pestisgenomes and the corresponding features in Y. pseudotuberculosis. Thereare strain-specific rearrangements, insertions, deletions, singlenucleotide polymorphisms and a unique distribution of insertionsequences. We found 453 single nucleotide polymorphisms in protein codingregions, which were used to assess evolutionary relationships of these Y.pestis strains. Gene reduction analysis revealed that the gene deletionprocesses are under selective pressure and many of the inactivations areprobably related to the organism s interaction with its host environment.The results presented here clearly demonstrate the differences betweenthe two Antiqua lineages and support the notion that grouping Y. pestisstrains based strictly on the classical definition of biovars (predicatedupon two biochemical assays) does not accurately reflect the phylogeneticrelationships within this species. Comparison of four virulent Y. pestisstrains with the human-avirulent strain 91001 provides further insightinto the genetic basis of virulence to humans.

  2. Complete Genome Sequence of Yersinis pestis Strains Antiqua and Nepa1516: Evidence of Gene Reduction in an Emerging Pathogen

    Energy Technology Data Exchange (ETDEWEB)

    Chain, Patrick S [ORNL; Hu, Ping [Lawrence Berkeley National Laboratory (LBNL); Malfatti, Stephanie [Lawrence Livermore National Laboratory (LLNL); Radnedge, Lyndsay [Lawrence Livermore National Laboratory (LLNL); Larimer, Frank W [ORNL; Vergez, Lisa [Lawrence Livermore National Laboratory (LLNL); Worsham, Patricia [U.S. Army Medical Research Institute of Infectious Diseases; Chu, May C [Centers for Disease Control and Prevention; Anderson, Gary L [Lawrence Berkeley National Laboratory (LBNL)

    2006-01-01

    Yersinia pestis, the causative agent of bubonic and pneumonic plagues, has undergone detailed study at the molecular level. To further investigate the genomic diversity among this group and to help characterize lineages of the plague organism that have no sequenced members, we present here the genomes of two isolates of the ''classical'' antiqua biovar, strains Antiqua and Nepal516. The genomes of Antiqua and Nepal516 are 4.7 Mb and 4.5 Mb and encode 4,138 and 3,956 open reading frames, respectively. Though both strains belong to one of the three classical biovars, they represent separate lineages defined by recent phylogenetic studies. We compare all five currently sequenced Y. pestis genomes and the corresponding features in Yersinia pseudotuberculosis. There are strain-specific rearrangements, insertions, deletions, single nucleotide polymorphisms, and a unique distribution of insertion sequences. We found 453 single nucleotide polymorphisms in protein-coding regions, which were used to assess the evolutionary relationships of these Y. pestis strains. Gene reduction analysis revealed that the gene deletion processes are under selective pressure, and many of the inactivations are probably related to the organism's interaction with its host environment. The results presented here clearly demonstrate the differences between the two biovar antiqua lineages and support the notion that grouping Y. pestis strains based strictly on the classical definition of biovars (predicated upon two biochemical assays) does not accurately reflect the phylogenetic relationships within this species. A comparison of four virulent Y. pestis strains with the human-avirulent strain 91001 provides further insight into the genetic basis of virulence to humans.

  3. The de novo transcriptome and its analysis in the worldwide vegetable pest, Delia antiqua (Diptera: Anthomyiidae).

    Science.gov (United States)

    Zhang, Yu-Juan; Hao, Youjin; Si, Fengling; Ren, Shuang; Hu, Ganyu; Shen, Li; Chen, Bin

    2014-03-10

    The onion maggot Delia antiqua is a major insect pest of cultivated vegetables, especially the onion, and a good model to investigate the molecular mechanisms of diapause. To better understand the biology and diapause mechanism of the insect pest species, D. antiqua, the transcriptome was sequenced using Illumina paired-end sequencing technology. Approximately 54 million reads were obtained, trimmed, and assembled into 29,659 unigenes, with an average length of 607 bp and an N50 of 818 bp. Among these unigenes, 21,605 (72.8%) were annotated in the public databases. All unigenes were then compared against Drosophila melanogaster and Anopheles gambiae. Codon usage bias was analyzed and 332 simple sequence repeats (SSRs) were detected in this organism. These data represent the most comprehensive transcriptomic resource currently available for D. antiqua and will facilitate the study of genetics, genomics, diapause, and further pest control of D. antiqua.

  4. The Complete Mitochondrial Genome of Delia antiqua and Its Implications in Dipteran Phylogenetics.

    Science.gov (United States)

    Zhang, Nai-Xin; Yu, Guo; Li, Ting-Jing; He, Qi-Yi; Zhou, Yong; Si, Feng-Ling; Ren, Shuang; Chen, Bin

    2015-01-01

    Delia antiqua is a major underground agricultural pest widely distributed in Asia, Europe and North America. In this study, we sequenced and annotated the complete mitochondrial genome of this species, which is the first report of complete mitochondrial genome in the family Anthomyiidae. This genome is a double-stranded circular molecule with a length of 16,141 bp and an A+T content of 78.5%. It contains 37 genes (13 protein-coding genes, 22 tRNAs and 2 rRNAs) and a non-coding A+T rich region or control region. The mitochondrial genome of Delia antiqua presents a clear bias in nucleotide composition with a positive AT-skew and a negative GC-skew. All of the 13 protein-coding genes use ATN as an initiation codon except for the COI gene that starts with ATCA. Most protein-coding genes have complete termination codons but COII and ND5 that have the incomplete termination codon T. This bias is reflected in both codon usage and amino acid composition. The protein-coding genes in the D. antiqua mitochondrial genome prefer to use the codon UUA (Leu). All of the tRNAs have the typical clover-leaf structure, except for tRNASer(AGN) that does not contain the dihydrouridine (DHU) arm like in many other insects. There are 7 mismatches with U-U in the tRNAs. The location and structure of the two rRNAs are conservative and stable when compared with other insects. The control region between 12S rRNA and tRNAIle has the highest A+T content of 93.7% in the D. antiqua mitochondrial genome. The control region includes three kinds of special regions, two highly conserved poly-T stretches, a (TA)n stretch and several G(A)nT structures considered important elements related to replication and transcription. The nucleotide sequences of 13 protein-coding genes are used to construct the phylogenetics of 26 representative Dipteran species. Both maximum likelihood and Bayesian inference analyses suggest a closer relationship of D. antiqua in Anthomyiidae with Calliphoridae, Calliphoridae is a

  5. The Complete Mitochondrial Genome of Delia antiqua and Its Implications in Dipteran Phylogenetics.

    Directory of Open Access Journals (Sweden)

    Nai-Xin Zhang

    Full Text Available Delia antiqua is a major underground agricultural pest widely distributed in Asia, Europe and North America. In this study, we sequenced and annotated the complete mitochondrial genome of this species, which is the first report of complete mitochondrial genome in the family Anthomyiidae. This genome is a double-stranded circular molecule with a length of 16,141 bp and an A+T content of 78.5%. It contains 37 genes (13 protein-coding genes, 22 tRNAs and 2 rRNAs and a non-coding A+T rich region or control region. The mitochondrial genome of Delia antiqua presents a clear bias in nucleotide composition with a positive AT-skew and a negative GC-skew. All of the 13 protein-coding genes use ATN as an initiation codon except for the COI gene that starts with ATCA. Most protein-coding genes have complete termination codons but COII and ND5 that have the incomplete termination codon T. This bias is reflected in both codon usage and amino acid composition. The protein-coding genes in the D. antiqua mitochondrial genome prefer to use the codon UUA (Leu. All of the tRNAs have the typical clover-leaf structure, except for tRNASer(AGN that does not contain the dihydrouridine (DHU arm like in many other insects. There are 7 mismatches with U-U in the tRNAs. The location and structure of the two rRNAs are conservative and stable when compared with other insects. The control region between 12S rRNA and tRNAIle has the highest A+T content of 93.7% in the D. antiqua mitochondrial genome. The control region includes three kinds of special regions, two highly conserved poly-T stretches, a (TAn stretch and several G(AnT structures considered important elements related to replication and transcription. The nucleotide sequences of 13 protein-coding genes are used to construct the phylogenetics of 26 representative Dipteran species. Both maximum likelihood and Bayesian inference analyses suggest a closer relationship of D. antiqua in Anthomyiidae with Calliphoridae

  6. Light spectrum regulates cell accumulation during daytime in the raphidophyte Chattonella antiqua causing noxious red tides.

    Science.gov (United States)

    Shikata, Tomoyuki; Matsunaga, Shigeru; Kuwahara, Yusuke; Iwahori, Sho; Nishiyama, Yoshitaka

    2016-07-01

    Most marine raphidophyte species cause noxious red tides in temperate coastal areas around the world. It is known that swimming abilities enable raphidophytes to accumulation of cells and to actively acquire light at surface layers and nutrients over a wide depth range. However, it remains unclear how the swimming behavior is affected by environmental conditions, especially light condition. In the present study, we observed the accumulation of the harmful red-tide raphidophyte Chattonella antiqua under various light conditions during the daytime in the laboratory. When exposed to ultraviolet-A/blue light (320-480nm) or red light (640-680nm) from above, cells moved downward. In the case of blue light (455nm), cells started to swim downward after 5-15min of irradiation at a photon flux density≥10μmolm(-2)s(-1). When exposed to monochromatic lights (400-680nm) from the side, cells moved away from the blue light source and then descended, but just moved downward under red light. However, mixing of green/orange light (520-630nm) diminished the effects of blue light. When exposed to a mixture of 30μmolm(-2)s(-1) of blue light (440nm) and ≥6μmolm(-2)s(-1) of yellow light (560nm) from above, cells did not move downward. These results indicate that blue light induces negative phototaxis and ultraviolet-A/blue and red lights induce descending, and green/orange light cancels out their effects in C. antiqua.

  7. Variability of factors driving spatial and temporal dispersion in river plume and Chattonella antiqua bloom in the Yatsushiro Sea, Japan.

    Science.gov (United States)

    Aoki, Kazuhiro; Onitsuka, Goh; Shimizu, Manabu; Kuroda, Hiroshi; Matsuo, Hitoshi; Kitadai, Yuuki; Sakurada, Kiyonari; Ando, Hidenori; Nishi, Hiromi; Tahara, Yoshio

    2014-04-15

    The dynamics of river plume in relation to harmful blooms of the raphidophycean flagellate, Chattonella antiqua in summer 2008-2010 in the Yatsushiro Sea, Japan were studied using a hydrodynamic model and monitoring data. In the southern area, the bloom formed in the waters stratified by a halocline caused by the southward expansion of riverine water from the Kuma River after the bloom initially forming in the northern area. The timing of the southward riverine water advection can be explained by the balance between the wind stress term and the pressure gradient term calculated from the horizontal density difference between the northern and southern areas. The wind stress and pressure gradient terms were evaluated using the sea surface temperature, salinity, wind speed and direction at two stations. Real time monitoring or continuous observations in these areas will enable nowcasts of bloom expansion when a bloom develops in the northern area.

  8. Insight into the possible mechanism of the summer diapause of Delia antiqua (Diptera: Anthomyiidae) through digital gene expression analysis.

    Science.gov (United States)

    Hao, You-Jin; Zhang, Yu-Juan; Si, Feng-Ling; Fu, Dan-Ying; He, Zheng-Bo; Chen, Bin

    2016-06-01

    The onion fly, Delia antiqua, is a major underground agricultural pest that can enter pupal diapause in the summer and winter seasons. However, little is known about its molecular regulation due to the lack of genomic resources. To gain insight into the possible mechanism of summer diapause (SD), high-throughput RNA-Seq data were generated from non-diapause (ND) and SD (initial, maintenance and quiescence phase) pupae. Three pair-wise comparisons were performed and identified, 1380, 1471 and 435, and were significantly regulated transcripts. Further analysis revealed that the enrichment of several functional terms related to juvenile hormone regulation, cell cycle, carbon hydrate and lipid metabolism, innate immune and stress responses, various signalling transductions, ubiquitin-dependent proteosome, and variation in cuticular and cytoskeleton components were found between ND and SD and between different phases of SD. Global characterization of transcriptome profiling between SD and ND contributes to the in-depth elucidation of the molecular mechanism of SD. Our results also offer insights into the evolution of insect diapause and support the importance of using the onion fly as a model to compare the molecular regulation events of summer and winter diapauses.

  9. Distribution and growth of Vibrio parahaemolyticus in southern Chilean clams (Venus antiqua) and blue mussels (Mytilus chilensis).

    Science.gov (United States)

    Aranda, Carlos P; Yévenes, Marco; Rodriguez-Benito, Cristina; Godoy, Félix A; Ruiz, Magdalena; Cachicas, Viviana

    2015-01-01

    We evaluated the distribution and growth of Vibrio parahaemolyticus in the inland sea of southern Chile, where the world's largest foodborne gastroenteritis outbreak by the pandemic strain O3:K6 occurred in 2005. Intertidal samples of Mytilus chilensis and Venus antiqua were collected around port towns between 41°28'S and 43°07'S, during April to May 2011 and January to March 2012. We used most probable number real-time polymerase chain reaction (MPN-PCR) for enumeration of the tlh, tdh, and trh genes in freshly harvested bivalves and after a controlled postharvest temperature abuse. Pathogenic markers (tdh+ or trh+) were not detected. Total V. parahaemolyticus (tlh+) in freshly harvested samples reached up to 0.38 and 3.66 log MPN/g in 2011 and 2012, respectively, with values close to or above 3 log MPN/g only near Puerto Montt (41°28'S, 72°55'W). Enrichments by temperature abuse (>2 log MPN/g) occurred mainly in the same zone, regardless of the year, suggesting that both natural or anthropogenic exposure to high temperatures were more critical. Lower salinity and higher sea surface temperature in Reloncaví Sound and Reloncaví Estuary were consistent with our observations and allowed confirmation of the existence of a high-risk zone near Puerto Montt. Based on the results, a strategy focused on risk management inside this defined hazard zone is recommended.

  10. Predicting the current potential and future world wide distribution of the onion maggot, Delia antiqua using maximum entropy ecological niche modeling

    Science.gov (United States)

    Feng, Jinian

    2017-01-01

    Climate change will markedly impact biology, population ecology, and spatial distribution patterns of insect pests because of the influence of future greenhouse effects on insect development and population dynamics. Onion maggot, Delia antiqua, larvae are subterranean pests with limited mobility, that directly feed on bulbs of Allium sp. and render them completely unmarketable. Modeling the spatial distribution of such a widespread and damaging pest is crucial not only to identify current potentially suitable climactic areas but also to predict where the pest is likely to spread in the future so that appropriate monitoring and management programs can be developed. In this study, Maximum Entropy Niche Modeling was used to estimate the current potential distribution of D. antiqua and to predict the future distribution of this species in 2030, 2050, 2070 and 2080 by using emission scenario (A2) with 7 climate variables. The results of this study show that currently highly suitable habitats for D.antiqua occur throughout most of East Asia, some regions of North America, Western Europe, and Western Asian countries near the Caspian sea and Black Sea. In the future, we predict an even broader distribution of this pest spread more extensively throughout Asia, North America and Europe, particularly in most of European countries, Central regions of United States and much of East Asia. Our present day and future predictions can enhance strategic planning of agricultural organizations by identifying regions that will need to develop Integrated Pest Management programs to manage the onion maggot. The distribution forecasts will also help governments to optimize economic investments in management programs for this pest by identifying regions that are or will become less suitable for current and future infestations. PMID:28158259

  11. Chromosal rearrangements in the onion fly Hylemya antiqua (Meigen), induced and isolated for genetic insect control purposes : studies on cytogenetics and fertility, with emphasis on an X-linked translocation

    NARCIS (Netherlands)

    Heemert, van C.

    1975-01-01

    The aim of this investigation was to isolate structural chromosome mutations causing "semi"-sterility which can be used for genetic control of the onion fly Hylemya antiqua (Meigen). For the induction, X-rays or fast neutrons were applied in different doses on males and females. "Semi"-sterile famil

  12. cDNA Cloning and Sequence Analysis of ADH Gene in Delia antiqua%葱蝇ADH基因的克隆及序列分析

    Institute of Scientific and Technical Information of China (English)

    陈春露; 陈斌; 司风玲; 何正波

    2012-01-01

    【目的】对葱蝇(De如antiqua)ADH基因进行克隆,并对其进行序列分析。【方法】通过RACE的方法克隆葱蝇ADH基因的cDNA序列,同时对该序列进行同源性分析、氨基酸序列比对和系统发育分析。[结果]试验获得的cDNA全长1088bp,其中ORF771bp,编码256个氨基酸,推测其相对分子质量为30.80kDa,等电点为8.22;通过该基因推导的氨基酸序列与其他物种的ADH进行相似性比较和系统发育分析,发现葱蝇与刺舌蝇(Glossina morsitans morsitoas)氨基酸序列的同源性最高。【结论】该研究为ADH基因的进一步研究提供了基础。%[Objective] This study aims to conduct cloning and sequence analysis of ADH gene in D. Antiqua. [Method] Full-length cDNA of ADH gene in D. antiqua was cloned by using RACE technology (GenBank access number: JQ666006). Analysis of the homology, characteristics and functional domains of ADH sequence and the phy- Iogenetic relationship to other dipteran ADH were conducted. [Result] The full length of ADH cDNA is 1 088 bp containing a 771 bp of ORF, encoding 256 amino acids, with a calculated relative molecular weight of 30.80 kDa and a theoretical isoelectric point of 8.22. The deduced amino acid sequence shares the highest homology with Glossina morsitans morsitans based on homological analysis and phylogenetic analysis. [Conclusion] This study provides basis for further research of ADH gene.

  13. Gene cloning, characterization and expression and enzymatic activities related to trehalose metabolism during diapause of the onion maggot Delia antiqua (Diptera: Anthomyiidae).

    Science.gov (United States)

    Guo, Qiang; Hao, You-Jin; Li, Yuan; Zhang, Yu-Juan; Ren, Shuang; Si, Feng-Ling; Chen, Bin

    2015-07-01

    Trehalose represents the main hemolymph sugar in many insects, and it functions in energy metabolism and protection in extreme environmental conditions. To gain an insight into trehalose functions in Delia antiqua diapausing pupae, genes encoding trehalose-6-phosphate synthase (TPS), trehalose-6-phosphatase (TPP) and trehalase (TRE) were identified and characterized. Analysis of the deduced amino acid sequences indicated that these genes were highly similar to each homolog from Diptera insects. Gene expressions and their enzyme activities were also investigated. The differential expressions of TPS and TPP shared very similar trends for summer and winter diapausing pupae. Their enzyme activities were consistent with the gene expressions. Trehalose concentrations in summer- and winter-diapausing pupae were lower at the initial phase (4.37-5.09μg/mg) but increased gradually and peaked in the maintenance phase (10.59-14.36μg/mg); the concentrations then declined in the quiescence phase. We speculated that a higher trehalose content during the maintenance stage may contribute to protein and/or biological membrane stabilization in winter or to desiccation resistance in the summertime. Diapause termination requires a decrease in the trehalose concentration to promote pupal-adult development. The glucose content also varied during the diapausing processes. Our results provide an overview of the differential expression levels of trehalose metabolic enzymes, confirming the important roles of trehalose in diapausing pupae of the onion maggot. Further work remains to explore its actual functions.

  14. cDNA Cloning and Sequence Analysis of ADH Gene in Delia antiqua%葱蝇ADH基因的克隆及序列分析

    Institute of Scientific and Technical Information of China (English)

    陈春露; 陈斌; 司风玲; 何正波

    2012-01-01

    [ Objective ] The aim was to clone the ADH gene of Delia antiqun, and carry out a sequence analysis. [ Method ] The cDNA sequence of ADH gene was cloned with the method of RACE, and then studied with homology analysis, comparison of amino acid sequence and phylogenetic analysis. [Result] The full length of cDNA obtained was 1 088 bp, among which there were 771 bp of ORF, encoding a protein of 256 amino acids with a calculated molecular weight of 30.80 kKa and a theoretical isolectric point of 8.22. The deduced amino acid sequence had the highest identity with that of Glossina morsitans based on homological analysis,and a phylogenic tree was inferred with homological ADH sequences from other insects. [ Conclusion ] The study provides a basis for the further research of ADH gene.%[目的]对葱蝇(Delia antiqua)ADH基因进行克隆,并对其进行序列分析.[方法]通过RACE的方法克隆葱蝇ADH基因的cDNA序列,同时对该序列进行同源性分析、氨基酸序列比对和系统发育分析.[结果]试验获得的cDNA全长1 088 bp,其中ORF 771 bp,编码256个氨基酸,推测其相对分子质量为30.80 kDa,等电点为8.22;通过该基因推导的氨基酸序列与其他物种的ADH进行相似性比较和系统发育分析,发现葱蝇与刺舌蝇(Glossina morsuans)氨基酸序列的同源性最高.[结论]该研究为ADH基因的进一步研究提供了基础.

  15. 粘虫板对葱地种蝇成虫的诱杀效果%Trapping efficiency of sticky insect boards against Delia antiqua in the fields

    Institute of Scientific and Technical Information of China (English)

    周方园; 王钲; 赵海鹏; 王山宁; 薛明

    2012-01-01

    为探明黄色、深蓝色、浅蓝色和银灰色4种颜色粘虫板对葱地种蝇成虫的诱集效果,于大蒜田葱地种蝇成虫发生期,在田间摆放上述不同颜色的粘虫板,每日检查粘虫板诱集成虫的数量,比较不同颜色、不同摆放方式和喷布诱集物质粘虫板的诱杀效果.结果表明,4种颜色粘虫板对成虫的诱集效果以深蓝色最好,浅蓝色次之,黄色和银灰色效果差.粘虫板在大蒜行间高立放和低立放的诱杀效果均好,且差异不显著,而平放的单面诱集效果优于立放的单面诱集效果.在蓝色粘虫板上喷布10%蜂蜜水能显著增加对葱地种蝇成虫的诱集效果.%During the occurring stage of Delia antique (Meigen) adults, field comparative experiments were conducted to detect trapping efficiency of yellow, dark blue, light blue and silver gray sticky insect boards, different placements and different honey concentrations sprayed on the surfaces of these boards. Trapping efficiency of sticky insect boards was investigated in the fields by checking the numbers of D. Antiqua on the boards every day. The results showed that the trapping efficiency of dark blue sticky insect boards was the best among the boards of four different colors, and the light blue sticky insect boards were a bit better than the yellow and silver gray ones. The trapping efficiency of two different placements (higher-vertical and lower-vertical placement) were both high without significant differences, and the single-side trapping efficiency of horizontal placements on the ground was better than the vertical ones (single-side). The boards with 10% honey solution sprayed on the surface could significantly improve the trapping efficiency.

  16. 葱蝇PDK1基因的克隆及生物信息学分析%Cloning and Bioinformatic Analysis of the PDK1 Gene in the Onion Maggot, Delia antiqua

    Institute of Scientific and Technical Information of China (English)

    申力; 郝友进; 罗钱春; 陈斌

    2014-01-01

    3-磷酸肌醇依赖性蛋白激酶1(3-phosphoinositide-dependent protein kinase 1,PDK1)是磷脂酰肌醇3激酶(Phosphatidylinositol-3 kinase,PI3K)/蛋白激酶B(PKB/Akt)信号通路中一个关键的激酶.该通路在人(Homo sapiens)、黑腹果蝇(Drosophila melanogaster)、秀丽隐杆线虫(Caenorhabditis elegans)中是一条保守的通路,通过激活下游的因子对代谢、细胞分化、寿命等产生重要调节作用.本研究基于葱蝇(Delia antiqua)转录组数据通过生物信息学分析从其中鉴定出PDK1基因4条Unigene序列,并通过PCR技术克隆了PDK1基因的全长cDNA,命名为DaPDK1,其全长为3 215bp,开放阅读框长2 730 bp,编码909个氨基酸.采用生物信息学的方法,推测该基因编码的蛋白质相对分子质量为100.3kD,等电点为8.53.该蛋白第87~109氨基酸是跨膜区,第284~627和744~833氨基酸是两个保守结构域STKc和PH.同源性分析表明DaPDK1蛋白与地中海实蝇(Ceratitis capitata)PDK1蛋白氨基酸序列相似性最高(一致率为53.1%,相似率为63.2%).本研究结果有望为进一步研究葱蝇PI3K/Akt信号通路中PDK1基因的特性及功能奠定基础.

  17. Comparison of the developmental and morphological characteristics of non-, winter- and summer-diapausing pupae of the onion maggot, Delia antiqua ( Diptera : Anthomyiidae)%葱蝇非滞育、冬滞育和夏滞育蛹发育和形态特征比较

    Institute of Scientific and Technical Information of China (English)

    黎万顺; 陈斌; 何正波

    2012-01-01

    maggot Delia antiqua as the model species through anatomic and photographed observation and measurement, with emphasis on the head evagination- and diapause-related characteristics. The study aims to understand the differences of developmental and morphological characteristics of ND, WD and SD pupae, and lays a morphological base for the distinguishment of diapause developmental stage and study of diapause molecular mechanism. The developmental durations of pre-diapause, diapause and post-diapause of WD pupae were 4, 85 and 27 d, respectively, while those for SD pupae were 2, 8 and 22 d, respectively. The pre-diapause begins at the pupation stage, and ends when the free fat body appears in the central area of eyes, which happens 10 h after the completion of head evagination. The completion of head evagination is the premise of diapause occurrence, the head evagination of ND, SD and WD pupae happened at 48, 36 and 83 h after pupation, and there was no morphological difference observed in the developmental process of head evagination between these three kinds of pupae. During the process of head evagination, firstly, the head capsule and thoracic appendages turned out from thorax capsule, and the head got to the location and shape of matured pupae; then, the abdominal muscles continued contraction to push the haemolymph and fat body into the head capsule and thoracic appendages. The pupae entered SD and WD when approximate 15% total effective accumulated temperature was obtained at the pupal stage. In the duration of diapause, the pupal morphology remained in the form of the appearance of free fat body in the central area of eyes, and no difference was observed between these two kinds of diapausing pupae in morphology in the diapause stage. The WD pupae had the largest body length, width and weight, followed by SD pupae and then ND pupae. At the post-diapause stage, malpighian tubules of ND pupae were green and clearly visible during the existence of the yellow body

  18. Interpreting Evidence.

    Science.gov (United States)

    Munsart, Craig A.

    1993-01-01

    Presents an activity that allows students to experience the type of discovery process that paleontologists necessarily followed during the early dinosaur explorations. Students are read parts of a story taken from the "American Journal of Science" and interpret the evidence leading to the discovery of Triceratops and Stegosaurus. (PR)

  19. Balancing innovation and evidence.

    Science.gov (United States)

    Pilcher, Jobeth W

    2015-01-01

    Nurse educators are encouraged to use evidence to guide their teaching strategies. However, evidence is not always available. How can educators make decisions regarding strategies when data are limited or absent? Where do innovation and creativity fit? How can innovation be balanced with evidence? This article provides a discussion regarding other sources of evidence, such as extrapolations, theories and principles, and collective expertise. Readers are encouraged to review the options and then analyze how they might be applied to innovation in education.

  20. Evidence and evidence gaps – an introduction

    Science.gov (United States)

    Dreier, Gabriele; Löhler, Jan

    2016-01-01

    Background: Medical treatment requires the implementation of existing evidence in the decision making process in order to be able to find the best possible diagnostic, therapeutic or prognostic measure for the individual patient based on the physician’s own expertise. Clinical trials form the evidence base and ideally, their results are assembled, analyzed, summarized, and made available in systematic review articles. Beside planning, conducting, and evaluating clinical trials in conformity with GCP (good clinical practice), it is essential that all results of conducted studies are publicly available in order to avoid publication bias. This includes also the public registration of planned and cancelled trials. History: During the last 25 years, evidence-based medicine became increasingly important in medical care and research. It is closely associated with the names of Archibald Cochrane and David Sackett. About 15 years ago, the Deutsche Cochrane Zentrum (Cochrane Germany) and the Deutsche Netzwerk Evidenzbasierte Medizin e.V. (German Network for Evidence-based Medicine, DNEbM) were founded in Germany. In the International Cochrane Collaboration, clinicians and methodologists come together on an interdisciplinary level to further develop methods of evidence-based medicine and to discuss the topics of evidence generation and processing as well as knowledge transfer. Problem: Evidence is particularly important for physicians in the process of decision making, however, at the same time it is the base of a scientific proof of benefit for the patient and finally for the payers in health care. The closure of evidence gaps requires enormously high staff and financial resources, significant organizational efforts, and it is only successful when clinical and methodical expertise as well as specific knowledge in the field of clinical research are included. On the other hand, the knowledge has to be transferred into practice. For this purpose, practice guidelines, meetings

  1. Synthesizing Evidence: Synthesis Methods for Evidence Clearinghouses

    Science.gov (United States)

    Valentine, Jeff; Lau, Timothy

    2015-01-01

    Following the theme of the first two presentations, this presentation will focus on the choices available for research synthesis when summarizing research evidence. The presenters will describe the current research synthesis practice of the What Works Clearinghouse (WWC) as well as several alternative models, including inverse-variance weighted…

  2. What is Evidence? (editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2011-06-01

    Full Text Available Lately, I have been pondering what we really mean when we say “evidence based practice”? In LIS, we all know the definitions that have been proposed (Booth 2000, Eldredge 2000, Crumley and Koufogiannakis 2002, and which have not ever really been challenged. But have we ever said explicitly what qualifies as evidence in this model? The underlying assumption seems to be that evidence is research, hence, we are really talking about research-based practice, but we don’t actually use that term.Higgs and Jones (2000 note that evidence is “knowledge derived from a variety of sources that has been subjected to testing and has found to be credible.” The Oxford English Dictionary states that evidence is “something serving as a proof” (OED, 2011. Neither of these definitions of evidence notes that evidence equals research; research is only one form of evidence. It certainly isn’t the only form of evidence – so what, then, constitutes evidence?Rycroff-Malone et al. (2004 state that that in order for evidence based practice to create a broader evidence base in nursing, “the external, scientific and the internal, intuitive” need to be brought together. The external, scientific is what evidence based practice has been focused on, in the form of scientific research, but Rycroff-Malone et al. note that other elements such as clinical experience, patient experience, and information from the local context also need to be considered.In library and information practice, what are the other forms of evidence we need to consider? I propose that while research evidence is of high importance to our profession and knowledge, LIS practitioners need to first of all consider local evidence. Local evidence is found in our working environment and specific to the context in which we carry out our work. It includes such things as our experiences with patrons in particular contexts, and what we observe to work in such situations, assessment of programs

  3. Evidence and clinical judgement.

    Science.gov (United States)

    Macnaughton, R J

    1998-05-01

    Widespread acceptance of the neologism 'evidence-based medicine' (EBM) has had the consequences of obscuring what evidence really is, and of eroding the importance of judgement in clinical situations. In this essay I seek to correct this lack of balance in the view of clinical encounters as portrayed by EBM. A better understanding of what evidence is can be obtained by looking beyond medicine to the way in which scientists and detectives view evidence. In both spheres, the importance of judgement is emphasized, even if it is a technical type of judgement. Clinicians also employ a technical kind of judgement, similar to that in science and detective work, when assessing the evidence relating to the truth of a diagnosis for an individual patient; but judgements relating to the ongoing care and treatment of that patient are based on what Aristotle calls phronesis or 'practical wisdom'.

  4. [Evidence-based physiotherapy].

    Science.gov (United States)

    Bender, Tamás

    2013-12-01

    This article on physiotherapy presents some current evidence stating the strengths and weaknesses of the physiotherapeutic procedures. In the area of physiotherapy empirical data obtained during decades were overtaken by evidence from current studies. The author points out the great problem of physiotherapy, namely the heterogeneity of the applied parameters. Knowledge of current evidence may be very important and helpful for the physicians, but the author proposes, from the practical point of view, that physiotherapeutical procedures based on exprience and used for many years should not be entirely neglected. Nowadays physiotherapy plays an important role in the treament of locomotor diseases but its use is increasing in other fields of medicine, as well.

  5. Gait as evidence

    DEFF Research Database (Denmark)

    Lynnerup, Niels; Larsen, Peter Kastmand

    2014-01-01

    This study examines what in Denmark may constitute evidence based on forensic anthropological gait analyses, in the sense of pointing to a match (or not) between a perpetrator and a suspect, based on video and photographic imagery. Gait and anthropometric measures can be used when direct facial...... comparison is not possible because of perpetrators masking their faces. The nature of judicial and natural scientific forms of evidence is discussed, and rulings dealing with the admissibility of video footage and forensic evidence in general are given. Technical issues of video materials are discussed...

  6. Gait as evidence

    DEFF Research Database (Denmark)

    Lynnerup, Niels; Larsen, Peter Kastmand

    2014-01-01

    This study examines what in Denmark may constitute evidence based on forensic anthropological gait analyses, in the sense of pointing to a match (or not) between a perpetrator and a suspect, based on video and photographic imagery. Gait and anthropometric measures can be used when direct facial...... comparison is not possible because of perpetrators masking their faces. The nature of judicial and natural scientific forms of evidence is discussed, and rulings dealing with the admissibility of video footage and forensic evidence in general are given. Technical issues of video materials are discussed......, and the study also discusses how such evidence may be presented, both in written statements and in court. © The Institution of Engineering and Technology 2014....

  7. Evidence Standards and Litigation

    DEFF Research Database (Denmark)

    Guerra, Alice; Luppi, Barbara; Parisi, Francesco

    of the case. We study how these factors jointly affect the parties’ litigation expenditures and the selection of cases brought to the courts. The evidence standard has different effects on different types of cases, reducing litigation for high-merit cases when standards are set low and increasing litigation......In litigation models, the parties’ probability to succeed in a lawsuit hinge upon two main factors: the merits of the parties’ claims and their litigation efforts (Katz, 1988; Hirshleifer, 1989; Farmer and Pecorino, 1999). In this paper we extend this framework to consider an important procedural...... aspect of the legal system: the evidence standard. We recast the conventional rent-seeking model to consider how alternative evidence standards affect litigation choices. We analyze the interrelation between different evidence standards, the effectiveness of the parties’ efforts, and the merits...

  8. LTDNA Evidence on Trial

    Science.gov (United States)

    Roberts, Paul

    2016-01-01

    Adopting the interpretative/hermeneutical method typical of much legal scholarship, this article considers two sets of issues pertaining to LTDNA profiles as evidence in criminal proceedings. The section titled Expert Evidence as Forensic Epistemic Warrant addresses some rather large questions about the epistemic status and probative value of expert testimony in general. It sketches a theoretical model of expert evidence, highlighting five essential criteria: (1) expert competence; (2) disciplinary domain; (3) methodological validity; (4) materiality; and (5) legal admissibility. This generic model of expert authority, highlighting law's fundamentally normative character, applies to all modern forms of criminal adjudication, across Europe and farther afield. The section titled LTDNA Evidence in UK Criminal Trials then examines English and Northern Irish courts' attempts to get to grips with LTDNA evidence in recent cases. Better appreciating the ways in which UK courts have addressed the challenges of LTDNA evidence may offer some insights into parallel developments in other legal systems. Appellate court rulings follow a predictable judicial logic, which might usefully be studied and reflected upon by any forensic scientist or statistician seeking to operate effectively in criminal proceedings. Whilst each legal jurisdiction has its own unique blend of jurisprudence, institutions, cultures and historical traditions, there is considerable scope for comparative analysis and cross-jurisdictional borrowing and instruction. In the spirit of promoting more nuanced and sophisticated international interdisciplinary dialogue, this article examines UK judicial approaches to LTDNA evidence and begins to elucidate their underlying institutional logic. Legal argument and broader policy debates are not confined to considerations of scientific validity, contamination risks and evidential integrity, or associated judgments of legal admissibility or exclusion. They also crucially

  9. Evidence-based dentistry.

    Science.gov (United States)

    Chambers, David W

    2010-01-01

    Both panegyric and criticism of evidence-based dentistry tend to be clumsy because the concept is poorly defined. This analysis identifies several contributions to the profession that have been made under the EBD banner. Although the concept of clinicians integrating clinical epidemiology, the wisdom of their practices, and patients' values is powerful, its implementation has been distorted by a too heavy emphasis of computerized searches for research findings that meet the standards of academics. Although EBD advocates enjoy sharing anecdotal accounts of mistakes others have made, faulting others is not proof that one's own position is correct. There is no systematic, high-quality evidence that EBD is effective. The metaphor of a three-legged stool (evidence, experience, values, and integration) is used as an organizing principle. "Best evidence" has become a preoccupation among EBD enthusiasts. That overlong but thinly developed leg of the stool is critiqued from the perspectives of the criteria for evidence, the difference between internal and external validity, the relationship between evidence and decision making, the ambiguous meaning of "best," and the role of reasonable doubt. The strongest leg of the stool is clinical experience. Although bias exists in all observations (including searches for evidence), there are simple procedures that can be employed in practice to increase useful and objective evidence there, and there are dangers in delegating policy regarding allowable treatments to external groups. Patient and practitioner values are the shortest leg of the stool. As they are so little recognized, their integration in EBD is problematic and ethical tensions exist where paternalism privileges science over patient's self-determined best interests. Four potential approaches to integration are suggested, recognizing that there is virtually no literature on how the "seat" of the three-legged stool works or should work. It is likely that most dentists

  10. Lineamenti del rinnovato processo contenzioso amministrativo ecclesiale. Commento al m.p. Antiqua ordinatione di Benedetto XVI (parte seconda

    Directory of Open Access Journals (Sweden)

    Manuel Ganarin

    2011-09-01

    Full Text Available Contributo segnalato dalla prof.ssa Geraldina Boni, ordinario di Storia del Diritto canonico e dal prof. Andrea Zanotti, ordinario di Diritto canonico nella Facoltà di Giurisprudenza dell’Università degli Studi di Bologna, che ne attestano la scientificità e l’originalità.La prima parte del contributo, sino al punto n. 3 della Parte Seconda, è stato pubblicato nel mese di luglio del 2011. SOMMARIO: PARTE PRIMA: CONSIDERAZIONI PRELIMINARI – 1. “Signatura Apostolica lege propria regitur” (cost. ap. Pastor Bonus, art. 125. Il definitivo superamento delle Normae speciales e l’adeguata sistemazione della novella legislazione benedettina nell’articolato sistema delle fonti del diritto – 2. I tratti distintivi della Lex propria: in particolare, la sua ispirazione pragmatica e l’evoluzione della “nomenclatura” canonistica in materia di giustizia amministrativa – 3. La Segnatura Apostolica quale tribunal administrativum. Spunti per un’interpretazione sistematica del controverso c. 1400, § 2 CIC, conformemente all’indole definitoria della normativa codiciale ecclesiale – PARTE SECONDA: DISAMINA DELLA RATIO PROCEDENDI INTERNA AL SUPREMO FORO GIUDIZIARIO – 1. Prima fase – a L’interposizione del ricorso entro i limiti di decadenza posti all’esercizio del diritto fondamentale al giudizio e l’eventuale concessione della remissio in terminos a favore del ricorrente – b Contenuto, allegati e capita nullitatis dell’istanza introduttiva del giudizio – 2. La reiectio in limine dell’istanza irricevibile. Il controllo essenzialmente formale del Segretario del Supremo Tribunale della Segnatura – a La non pertinenza dell’oggetto sostanziale della domanda – b Presupposti e condizioni del ricorso di legittimità. In particolare, la capacitas standi in iudicio e la legitimatio activa della parte ricorrente – c L’inesistenza dell’oggetto formale del ricorso – d La decorrenza del termine per ricorrere: il c.d. ricorso tardivo – 3. Seconda fase: le attività del Segretario conseguenti all’accettazione preliminare del ricorso – a Premessa: l’identificazione dei soggetti del giudizio e la vexata quaestio relativa al possibile conflitto interistituzionale fra l’autorità amministrativa ecclesiastica inferiore ed il competente Dicastero della Curia Romana – b Ricorrente, resistente, controinteressato e terzi interventori. Parti principali e parti accessorie del processo amministrativo – c Contenzioso amministrativo e collaborazione fra istituzioni ecclesiali. L’esibizione del provvedimento impugnato e degli acta causae da parte del Dicastero resistente – d Il votum pro rei veritate e la peculiare “bidirezionalità” delle funzioni conferite al Promotore di giustizia – 4. L’attuazione del contraddittorio processuale nell’espletamento della c.d. istruttoria “documentale” – 5. Il giudizio di ammissibilità del Prefetto in Congresso – a La divaricazione tra impostazioni dottrinali e prassi applicativa relativamente al concetto di “manifesta infondatezza” del ricorso – b Segue. La riformulazione, de iure condendo, della diagnosi prefettizia e della struttura “trifasica” del processo contenzioso amministrativo canonico – 6. Terza fase: dalla contestazione della lite alla decisione del Collegium iudicans – a La summaria delibatio oralis, il c.d. supplemento d’istruttoria ed il compimento della fase decisoria – b Gli effetti tipici del giudicato amministrativo di rigetto. L’effetto “caducatorio” della sentenza di accoglimento e la sua incidenza nel sistema delle invalidità dell’atto giuridico canonico – c Segue. L’effetto “ripristinatorio” e l’effetto “conformativo” conseguenti all’annullamento della decisione impugnata – 7. La crisi irreversibile del processo amministrativo. Le ipotesi di litis finitio previste dal Codex iuris canonici e dalla Lex propria – a La morte del ricorrente e la c.d. ”sopravvenuta carenza di interesse” – b La persistente inerzia delle parti: la perenzione – c La rinuncia all’istanza giudiziale – d La revoca del provvedimento amministrativo – e La composizione pacifica della controversia – 8. La sospensione giudiziale dell’esecuzione dell’atto amministrativo singolare – a Vincolatività ed automaticità della tutela cautelare: il ricorso tantum in devolutivo ed il ricorso etiam in suspensivo – b I presupposti giuridici e sostanziali per la concessione della misura sospensiva – c Il procedimento incidentale: dal giudizio preliminare del Segretario alla deliberazione del Cardinale Prefetto

  11. Lineamenti del rinnovato processo contenzioso amministrativo ecclesiale. Commento al m.p. Antiqua ordinatione di Benedetto XVI

    Directory of Open Access Journals (Sweden)

    Manuel Ganarin

    2011-07-01

    Full Text Available Contributo segnalato dalla prof.ssa Geraldina Boni, ordinario di Storia del Dirittocanonico e dal prof. Andrea Zanotti, ordinario di Diritto canonico nella Facoltà diGiurisprudenza dell’Università degli Studi di Bologna, che ne attestano la scientificitàe l’originalità.In questa uscita se ne pubblica il testo sino al punto n. 3 della Parte Seconda.SOMMARIO: PARTE PRIMA: CONSIDERAZIONI PRELIMINARI – 1. “SignaturaApostolica lege propria regitur” (cost. ap. Pastor Bonus, art. 125. Il definitivosuperamento delle Normae speciales e l’adeguata sistemazione della novellalegislazione benedettina nell’articolato sistema delle fonti del diritto – 2. I trattidistintivi della Lex propria: in particolare, la sua ispirazione pragmatica el’evoluzione della “nomenclatura” canonistica in materia di giustiziaamministrativa – 3. La Segnatura Apostolica quale tribunal administrativum. Spuntiper un’interpretazione sistematica del controverso c. 1400, § 2 CIC, conformementeall’indole definitoria della normativa codiciale ecclesiale – PARTE SECONDA:DISAMINA DELLA RATIO PROCEDENDI INTERNA AL SUPREMO FOROGIUDIZIARIO – 1. Prima fase – a L’interposizione del ricorso entro i limiti didecadenza posti all’esercizio del diritto fondamentale al giudizio e l’eventualeconcessione della remissio in terminos a favore del ricorrente – b Contenuto,allegati e capita nullitatis dell’istanza introduttiva del giudizio – 2. La reiectio inlimine dell’istanza irricevibile. Il controllo essenzialmente formale del Segretariodel Supremo Tribunale della Segnatura – a La non pertinenza dell’oggettosostanziale della domanda – b Presupposti e condizioni del ricorso di legittimità.In particolare, la capacitas standi in iudicio e la legitimatio activa della partericorrente – c L’inesistenza dell’oggetto formale del ricorso – d La decorrenza deltermine per ricorrere: il c.d. ricorso tardivo – 3. Seconda fase: le attività delSegretario conseguenti all’accettazione preliminare del ricorso – a Premessa:l’identificazione dei soggetti del giudizio e la vexata quaestio relativa al possibileconflitto interistituzionale fra l’autorità amministrativa ecclesiastica inferiore ed ilcompetente Dicastero della Curia Romana – b Ricorrente, resistente,controinteressato e terzi interventori. Parti principali e parti accessorie del processoamministrativo – c Contenzioso amministrativo e collaborazione fra istituzioniecclesiali. L’esibizione del provvedimento impugnato e degli acta causae da partedel Dicastero resistente – d Il votum pro rei veritate e la peculiare “bidirezionalità”delle funzioni conferite al Promotore di giustizia – 4. L’attuazione delcontraddittorio processuale nell’espletamento della c.d. istruttoria “documentale” –5. Il giudizio di ammissibilità del Prefetto in Congresso – a La divaricazione traimpostazioni dottrinali e prassi applicativa relativamente al concetto di “manifestainfondatezza” del ricorso – b Segue. La riformulazione, de iure condendo, delladiagnosi prefettizia e della struttura “trifasica” del processo contenzioso amministrativo canonico – 6. Terza fase: dalla contestazione della lite alla decisionedel Collegium iudicans – a La summaria delibatio oralis, il c.d. supplementod’istruttoria ed il compimento della fase decisoria – b Gli effetti tipici del giudicatoamministrativo di rigetto. L’effetto “caducatorio” della sentenza di accoglimento ela sua incidenza nel sistema delle invalidità dell’atto giuridico canonico – c Segue.L’effetto “ripristinatorio” e l’effetto “conformativo” conseguenti all’annullamentodella decisione impugnata – 7. La crisi irreversibile del processo amministrativo. Leipotesi di litis finitio previste dal Codex iuris canonici e dalla Lex propria – a Lamorte del ricorrente e la c.d. ”sopravvenuta carenza di interesse” – b La persistenteinerzia delle parti: la perenzione – c La rinuncia all’istanza giudiziale – d Larevoca del provvedimento amministrativo – e La composizione pacifica dellacontroversia – 8. La sospensione giudiziale dell’esecuzione dell’atto amministrativosingolare – a Vincolatività ed automaticità della tutela cautelare: il ricorso tantumin devolutivo ed il ricorso etiam in suspensivo – b I presupposti giuridici esostanziali per la concessione della misura sospensiva – c Il procedimentoincidentale: dal giudizio preliminare del Segretario alla deliberazione delCardinale Prefetto

  12. Evidence-Based Development

    DEFF Research Database (Denmark)

    Hertzum, Morten; Simonsen, Jesper

    2004-01-01

    Systems development is replete with projects that represent substantial resource investments but result in systems that fail to meet users’ needs. Evidence-based development is an emerging idea intended to provide means for managing customer-vendor relationships and working systematically toward...... meeting customer needs. We are suggesting that the effects of the use of a system should play a prominent role in the contractual definition of IT projects and that contract fulfilment should be determined on the basis of evidence of these effects. Based on two ongoing studies of home-care management...

  13. A generalized evidence distance

    Institute of Scientific and Technical Information of China (English)

    Hongming Mo; Xi Lu; Yong Deng

    2016-01-01

    How to efficiently measure the distance between two basic probability assignments (BPAs) is an open issue. In this paper, a new method to measure the distance between two BPAs is proposed, based on two existing measures of evidence distance. The new proposed method is comprehen-sive and generalized. Numerical examples are used to ilus-trate the effectiveness of the proposed method.

  14. What Counts as Evidence?

    Science.gov (United States)

    Dougherty Stahl, Katherine A.

    2014-01-01

    Each disciplinary community has its own criteria for determining what counts as evidence of knowledge in their academic field. The criteria influence the ways that a community's knowledge is created, communicated, and evaluated. Situating reading, writing, and language instruction within the content areas enables teachers to explicitly…

  15. LTDNA Evidence on Trial

    Directory of Open Access Journals (Sweden)

    Paul Roberts

    2016-10-01

    Full Text Available Adopting the interpretative/hermeneutical method typical of much legal scholarship, this article considers two sets of issues pertaining to LTDNA profiles as evidence in criminal proceedings. Section 1 addresses some rather large questions about the epistemic status and probative value of expert testimony in general. It sketches a theoretical model of expert evidence, highlighting five essential criteria: (1 expert competence; (2 disciplinary domain; (3 methodological validity; (4 materiality; and (5 legal admissibility. This generic model of expert authority, highlighting law’s fundamentally normative character, applies to all modern forms of criminal adjudication, across Europe and farther afield. Section 2 then examines English and Northern Irish courts’ attempts to get to grips with LTDNA evidence in recent cases. Better appreciating the ways in which UK courts have addressed the challenges of LTDNA evidence may offer some insights into parallel developments in other legal systems. Appellate court rulings follow a predictable judicial logic, which might usefully be studied and reflected upon by any forensic scientist or statistician seeking to operate effectively in criminal proceedings. Whilst each legal jurisdiction has its own unique blend of jurisprudence, institutions, cultures and historical traditions, there is considerable scope for comparative analysis and cross-jurisdictional borrowing and instruction. In the spirit of promoting more nuanced and sophisticated international interdisciplinary dialogue, this article examines UK judicial approaches to LTDNA evidence and begins to elucidate their underlying institutional logic. Legal argument and broader policy debates are not confined to considerations of scientific validity, contamination risks and evidential integrity, or associated judgments of legal admissibility or exclusion. They also crucially concern the manner in which LTDNA profiling results are presented and explained to

  16. Multiple Lines of Evidence

    Energy Technology Data Exchange (ETDEWEB)

    Amidan, Brett G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Venzin, Alexander M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bramer, Lisa M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-06-03

    This paper discusses the process of identifying factors that influence the contamination level of a given decision area and then determining the likelihood that the area remains unacceptable. This process is referred to as lines of evidence. These lines of evidence then serve as inputs for the stratified compliance sampling (SCS) method, which requires a decision area to be divided into strata based upon contamination expectations. This is done in order to focus sampling efforts more within stratum where contamination is more likely and to use the domain knowledge about these likelihoods of the stratum remaining unacceptable to buy down the number of samples necessary, if possible. Two different building scenarios were considered as an example (see Table 3.1). SME expertise was elicited concerning four lines of evidence factors (see Table 3.2): 1) amount of contamination that was seen before decontamination, 2) post-decontamination air sampling information, 3) the applied decontaminant information, and 4) the surface material. Statistical experimental design and logistic regression modelling were used to help determine the likelihood that example stratum remained unacceptable for a given example scenario. The number of samples necessary for clearance was calculated by applying the SCS method to the example scenario, using the estimated likelihood of each stratum remaining unacceptable as was determined using the lines of evidence approach. The commonly used simple random sampling (SRS) method was also used to calculate the number of samples necessary for clearance for comparison purposes. The lines of evidence with SCS approach resulted in a 19% to 43% reduction in total number of samples necessary for clearance (see Table 3.6). The reduction depended upon the building scenario, as well as the level of percent clean criteria. A sensitivity analysis was also performed showing how changing the estimated likelihoods of stratum remaining unacceptable affect the number

  17. Evidence of clinical competence.

    Science.gov (United States)

    Lejonqvist, Gun-Britt; Eriksson, Katie; Meretoja, Riitta

    2012-06-01

    This cross-sectional research used a qualitative questionnaire to explore clinical competence in nursing. The aim was to look for evidence of how clinical competence showed itself in practice. In the research, the views from both education and working life are combined to broadly explore and describe clinical competence from the perspective of students, clinical preceptors and teachers. The questions were formulated on how clinical competence is characterised and experienced, what contributes to it and how it is maintained, and on the relation between clinical competence and evidence-based care. The answers were analysed by inductive content analysis. The results showed that clinical competence in practice is encountering, knowing, performing, maturing and improving. Clinical competence is an ongoing process, rather than a state and manifests itself in an ontological and a contextual dimension.

  18. Evidence on acne therapy

    Directory of Open Access Journals (Sweden)

    Caroline Sousa Costa

    Full Text Available Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin.

  19. Inflation, evidence and falsifiability

    CERN Document Server

    Gubitosi, Giulia; Magueijo, Joao; Allison, Rupert

    2015-01-01

    In this paper we consider the issue of paradigm evaluation by applying Bayes' theorem along the following nested chain of progressively more complex structures: i) parameter estimation (within a model), ii) model selection and comparison (within a paradigm), iii) paradigm evaluation. In such a chain the Bayesian evidence works both as the posterior's normalization at a given level and as the likelihood function at the next level up. Whilst raising no objections to the standard application of the procedure at the two lowest levels, we argue that it should receive an essential modification when evaluating paradigms, in view of the issue of falsifiability. By considering toy models we illustrate how unfalsifiable models and paradigms are always favoured by the Bayes factor. We argue that the evidence for a paradigm should not only be high for a given dataset, but exceptional with respect to what it would have been, had the data been different. We propose a measure of falsifiability (which we term predictivity), ...

  20. Evidence or Advocacy?

    DEFF Research Database (Denmark)

    Buhl, Mie

    2015-01-01

    in the reform (Ministry of Education, 2013, 2014). My aim is to discuss the impact of the educational discourse of evidence in which all school subjects are defined in the new reform. The discourse of evidence focuses on competences aimed at utility and future employment prospects. The new learning objectives......Introduction This paper presents and discusses the current role of Danish visual arts education in the compulsory school system. Denmark recently implemented a major school reform “How to make a good school better” (Ministry of Education, 2014), that focuses on core competences in the subjects...... Reading and Math. The reform emphasizes an open approach to various constellations of teaching and learning and includes a national tool for increasing the assessment of core competences. I examined visual arts education in the new educational landscape based on the agreement between the government...

  1. Evidence informed decision making

    DEFF Research Database (Denmark)

    Sharma, Tarang; Choudhury, Moni; Kaur, Bindweep

    2015-01-01

    from the literature and a combined best practice checklist has been proposed. CONCLUSIONS: As decisions often need to be made in areas where there is a lack of published scientific evidence, CE is employed. Therefore to ensure its appropriateness the development of a validated CE data quality check......-list to assist decision makers is essential and further research in this area is a priority....

  2. Evidence-based librarianship: searching for the needed EBL evidence.

    Science.gov (United States)

    Eldredge, J D

    2000-01-01

    This paper discusses the challenges of finding evidence needed to implement Evidence-Based Librarianship (EBL). Focusing first on database coverage for three health sciences librarianship journals, the article examines the information contents of different databases. Strategies are needed to search for relevant evidence in the library literature via these databases, and the problems associated with searching the grey literature of librarianship. Database coverage, plausible search strategies, and the grey literature of library science all pose challenges to finding the needed research evidence for practicing EBL. Health sciences librarians need to ensure that systems are designed that can track and provide access to needed research evidence to support Evidence-Based Librarianship (EBL).

  3. Emdogain: evidence of efficacy.

    Science.gov (United States)

    Greenstein, G

    2000-04-01

    This article addresses the use of enamel matrix proteins (Emdogain) to enhance regeneration of the periodontium. Information regarding the role of Emdogain to induce cementogenesis and histologic evidence in animals and humans that it can initiate regeneration of diseased sites are discussed. Several clinical trials have indicated that Emdogain plus modified Widman flap surgery provide a better result than the surgery alone. Several other investigations have indicated that flap surgery plus Emdogain or a bioabsorbable membrane achieve similar results. However, this latter finding needs further validation. Clinical examples of successful therapy with Emdogain are presented.

  4. Evidence in mental health.

    Science.gov (United States)

    Weeks, Susan Mace

    2014-12-01

    Health practitioners wishing to positively improve health outcomes for their clients have access to a unique set of collated tools to guide their practice. Systematic reviews provide guidance in the form of synthesized evidence that can form the basis of decision making as they provide care for their clients. This article describes systematic reviews as a basis for informed decision making by mental health practitioners. The process of systematic review is discussed, examples of existing systematic review topics relevant to mental health are presented, a sample systematic review is described, and gaps and emerging topics for mental health systematic reviews are addressed.

  5. Realism And Empirical Evidence

    CERN Document Server

    Schmelzer, I

    1997-01-01

    We define realism using a slightly modified version of the EPR criterion of reality. This version is strong enough to show that relativity is incomplete. We show that this definition of realism is nonetheless compatible with the general principles of causality and canonical quantum theory as well as with experimental evidence in the (special and general) relativistic domain. We show that the realistic theories we present here, compared with the standard relativistic theories, have higher empirical content in the strong sense defined by Popper's methodology.

  6. Evidence for homosexuality gene

    Energy Technology Data Exchange (ETDEWEB)

    Pool, R.

    1993-07-16

    A genetic analysis of 40 pairs of homosexual brothers has uncovered a region on the X chromosome that appears to contain a gene or genes for homosexuality. When analyzing the pedigrees of homosexual males, the researcheres found evidence that the trait has a higher likelihood of being passed through maternal genes. This led them to search the X chromosome for genes predisposing to homosexuality. The researchers examined the X chromosomes of pairs of homosexual brothers for regions of DNA that most or all had in common. Of the 40 sets of brothers, 33 shared a set of five markers in the q28 region of the long arm of the X chromosome. The linkage has a LOD score of 4.0, which translates into a 99.5% certainty that there is a gene or genes in this area that predispose males to homosexuality. The chief researcher warns, however, that this one site cannot explain all instances of homosexuality, since there were some cases where the trait seemed to be passed paternally. And even among those brothers where there was no evidence that the trait was passed paternally, seven sets of brothers did not share the Xq28 markers. It seems likely that homosexuality arises from a variety of causes.

  7. Evidence on Inclusion

    DEFF Research Database (Denmark)

    Dyssegaard, Camilla Brørup; Larsen, Michael Søgaard

    The purpose of this publication is to examine existing research on inclusion to identify strategies of inclusion that have generated positive effects. To do so it is necessary to understand the effect of the applied strategies. One approach, which is being discussed, is to use evidence to determine...... which methods have proven more effective than others. The desire to gain insight into research on inclusion forms the basis of the current systematic review. The task was to determine which strategies primary research has found to be most effective for inclusion purposes. We have solved this task...... by addressing the existing research with the following question: What is the effect of including children with special needs in mainstream teaching in basic school, and which of the applied educational methods have proved to have a positive effect?...

  8. Evidence Locator: sources of evidence-based dentistry information.

    Science.gov (United States)

    Frantsve-Hawley, Julie

    2008-09-01

    Multiple resources are available to help practitioners access the latest scientific evidence. Evidence-based dentistry (EBD) is an approach to clinical decision making that incorporates the most current and comprehensive scientific evidence with the practitioner's judgment and the patient's needs and preferences. One challenge in implementing this approach is access to evidence, and there are multiple online resources that can be used in this endeavor. This article presents the Evidence Locator, a list of Web sites that provide access to "secondary sources" of evidence. Such "secondary sources" are typically summaries of systematic reviews and evidence-based clinical recommendations or guidelines. Also presented is a list of other Web sites that may be useful to the practitioner in implementing EBD.

  9. Evidence-Based Laboratory Medicine

    Institute of Scientific and Technical Information of China (English)

    Christopher P Price

    2004-01-01

    @@ Whilst there have been several definitions of Evidence-Based Medicine (EBM), the one given by David Sackett is probably the most accurate and well accepted; he stated that "evidence-based medicine is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients"[1].

  10. Limits of Evidence within EU

    Directory of Open Access Journals (Sweden)

    Monica Pocora

    2015-05-01

    Full Text Available The issue of admissibility of evidence has been regulated only very scarcely in the EU. Judicial cooperation in criminal matters has been embracing the increasing number of instruments, covering plethora of aspects, however, the field of admissibility of evidence remains almost untouched. Can the Area of Freedom, Security and Justice be called the Common Evidence Area? From the national perspective, the issue of admissibility of evidence is still subject to divergent solutions in the Member States, concerning the common law and continental law systems, i.e. the right of access to a lawyer. Thus, the paper aims to take into account the tendencies of legal rule in matter of admissibility of evidence, the dynamic of evidence movement within EU area.

  11. Evidence and Ethics (Editorial

    Directory of Open Access Journals (Sweden)

    Alison Brettle

    2012-12-01

    Full Text Available Welcome to the December issue of EBLIP, the final issue of my first year as Editor-in-Chief. A year which I have thoroughly enjoyed and one where the fears over what to write in my editorials haven’t materialised. This quarter, ethics has featured quite heavily in my working life so I decided to make this the topic of the editorial, sharing some of my thoughts regarding evidence, ethics and how ethical principles are implemented within the EBLIP journal.Ethics are “principles of conduct or standards of behaviour governing an individual or profession” (Library and Information Science Editorial Committee, 2010, and as individuals or professionals we may be governed by various ethical codes. As I'm sure you know, EBLIP originated in the health domain, where ethical values and ethical research feature strongly. Indeed, by its formal definition, research cannot take place unless “ethical approval” from an appropriate committee has been granted. The practicalities of taking research through the ethical approval process can often be time consuming, and those involved in research need to bear this in mind when planning a project. Each committee will have a slightly different form and process (which can add to the frustration of the researcher, but basically will make their decision to approve on the basis that the research includes obtaining informed consent from participants (i.e., participants know what the research is about and what their involvement will mean; that the research will not cause harm to participants; that confidentiality will be maintained; and that the research undertaken is methodologically rigorous and worthwhile. Preparing a proposal for ethical approval, whilst time consuming, makes the researcher think about all aspects of the research and how it is going to be operationalized, which can save lots of time and effort in the long run and may well also improve the research design. These principles are the same whatever

  12. Psiquiatria baseada em evidências Evidence-based psychiatry

    Directory of Open Access Journals (Sweden)

    Maurício S de Lima

    2000-09-01

    Full Text Available Em psiquiatria, observa-se grande variabilidade de práticas clínicas, muitas vezes desnecessária. Essas variações podem estar relacionadas à ausência de evidência científica confiável ou ao desconhecimento das evidências de boa qualidade disponíveis. A medicina baseada em evidências (MBE é uma combinação de estratégias que busca assegurar que o cuidado individual do paciente seja baseado na melhor informação disponível, a qual deve ser incorporada à prática clínica. Neste artigo, conceitos de MBE são discutidos com relação a aspectos e desafios no tratamento de pacientes com distimia, bulimia nervosa e esquizofrenia. A partir de resultados de três revisões sistemáticas recentemente publicadas, conclui-se que a prática de psiquiatria baseada em evidências acrescenta qualidade à prática psiquiátrica tradicional.The unnecessary variability often seen in the clinical practice can be related to both the absence of reliable evidence and unawareness of the existence of good quality evidence. Evidence-Based Medicine (EBM is a set of linked strategies designed to assist clinicians in keeping themselves up-to-date with the best available evidence. Such evidence must be incorporated into the clinical practice. EBM concepts are discussed here through common aspects and challenges doctors face when treating patients with dysthymia, bulimia nervosa, and schizophrenia. In the light of some results from three systematic reviews it is concluded that Evidence-Based Psychiatry strategies, rather than replacing the traditional ones, may be a valuable tool to improving quality in a good clinical practice.

  13. Evidence-based clinical practice

    DEFF Research Database (Denmark)

    Gluud, Christian

    2002-01-01

    Evidence-based medicine combines the patient's preferences with clinical experience and the best research evidence. Randomized clinical trials are considered the most valid research design for evaluating health-care interventions. However, empirical research shows that intervention effects may be...

  14. Standardized description of scientific evidence using the Evidence Ontology (ECO).

    Science.gov (United States)

    Chibucos, Marcus C; Mungall, Christopher J; Balakrishnan, Rama; Christie, Karen R; Huntley, Rachael P; White, Owen; Blake, Judith A; Lewis, Suzanna E; Giglio, Michelle

    2014-01-01

    The Evidence Ontology (ECO) is a structured, controlled vocabulary for capturing evidence in biological research. ECO includes diverse terms for categorizing evidence that supports annotation assertions including experimental types, computational methods, author statements and curator inferences. Using ECO, annotation assertions can be distinguished according to the evidence they are based on such as those made by curators versus those automatically computed or those made via high-throughput data review versus single test experiments. Originally created for capturing evidence associated with Gene Ontology annotations, ECO is now used in other capacities by many additional annotation resources including UniProt, Mouse Genome Informatics, Saccharomyces Genome Database, PomBase, the Protein Information Resource and others. Information on the development and use of ECO can be found at http://evidenceontology.org. The ontology is freely available under Creative Commons license (CC BY-SA 3.0), and can be downloaded in both Open Biological Ontologies and Web Ontology Language formats at http://code.google.com/p/evidenceontology. Also at this site is a tracker for user submission of term requests and questions. ECO remains under active development in response to user-requested terms and in collaborations with other ontologies and database resources. Database URL: Evidence Ontology Web site: http://evidenceontology.org.

  15. NASA 2010 Pharmacology Evidence Review

    Science.gov (United States)

    Steinberg, Susan

    2011-01-01

    In 2008, the Institute of Medicine reviewed NASA's Human Research Program Evidence in assessing the Pharmacology risk identified in NASA's Human Research Program Requirements Document (PRD). Since this review there was a major reorganization of the Pharmacology discipline within the HRP, as well as a re-evaluation of the Pharmacology evidence. This panel is being asked to review the latest version of the Pharmacology Evidence Report. Specifically, this panel will: (1) Appraise the descriptions of the human health-related risk in the HRP PRD. (2) Assess the relevance and comprehensiveness of the evidence in identifying potential threats to long-term space missions. (3) Assess the associated gaps in knowledge and identify additional areas for research as necessary.

  16. Forensic Botany: Evidence and Analysis.

    Science.gov (United States)

    Coyle, H M

    2009-01-01

    Forensic botany is the use of plant evidence in matters of law. While plant fragments are often collected as trace evidence, they are only occasionally identified using microscopy and are still more rarely assessed using molecular biology techniques for individualization and sourcing of a sample. There are many different methods useful for DNA typing of plants; this review focuses on those techniques (DNA sequencing, STR, AFLP, RAPD) most relevant to the forensic science community and on those methods currently in practice. Plant evidence is commonly associated with homicides, with clandestine graves, as trace pollen on clothing, vehicles, or packaging, or in the transport of illicit drugs. DNA can be especially useful for the identification of minute quantity of samples, for differentiation of plants that lack distinguishing morphological features, and for generating a unique identifier for associative forensic evidence.

  17. Gravitational Waves: The Evidence Mounts

    Science.gov (United States)

    Wick, Gerald L.

    1970-01-01

    Reviews the work of Weber and his colleagues in their attempts at detecting extraterrestial gravitational waves. Coincidence events recorded by special detectors provide the evidence for the existence of gravitational waves. Bibliography. (LC)

  18. Evidence in the learning organization

    OpenAIRE

    Umscheid Craig A; Richardson W Scott; Akl Elie A; McNamara Megan C; Crites Gerald E; Nishikawa James

    2009-01-01

    Abstract Background Organizational leaders in business and medicine have been experiencing a similar dilemma: how to ensure that their organizational members are adopting work innovations in a timely fashion. Organizational leaders in healthcare have attempted to resolve this dilemma by offering specific solutions, such as evidence-based medicine (EBM), but organizations are still not systematically adopting evidence-based practice innovations as rapidly as expected by policy-makers (the know...

  19. Evidence-Based Cancer Imaging

    Science.gov (United States)

    Khorasani, Ramin

    2017-01-01

    With the advances in the field of oncology, imaging is increasingly used in the follow-up of cancer patients, leading to concerns about over-utilization. Therefore, it has become imperative to make imaging more evidence-based, efficient, cost-effective and equitable. This review explores the strategies and tools to make diagnostic imaging more evidence-based, mainly in the context of follow-up of cancer patients.

  20. Persuasive Evidence: Improving Customer Service through Evidence Based Librarianship

    Directory of Open Access Journals (Sweden)

    Wendy A. Abbott

    2006-03-01

    Full Text Available Objective - To demonstrate how evidence based practice has contributed to informaing decisions and resolving issues if concern in service delivery at Bond University Librray. Methods - This paper critically analyses three evidence based research projects conducted at Bond University Library. Each project combined a range of research methods including surveys, literature reviews and the analysis of internal performance data to find solutions to problems in library service delivery. The first research project investigated library opening hours and the feasability of twenty-four hour opening. Another project reseached questions about the management of a collection of feature films on DVD and video. The thrd project investigated issues surrounding the teaching of EndNote to undergarduate students. Results - Despite some deficiencies in the methodologies used, each evidence based research project had positive outcomes. One of the highlights asn an essential feature of the process at Bond University Library was the involvement of stakeholders. The ability to build consensus and agree action plans with stakeholders was an important outcome of that process. Conclusion - Drawing on the experience of these research projects, the paper illustrates the benefits of evidence based information practice to stimulate innovation and improve library services. Librarians, like most professionals, need to continue to develop the skills and a culture to effectively carry out evidence based practice.

  1. From evidence-based to evidence-reflected practice

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    “Knowledge” is of the utmost significance for professional practice and learning. Today, though, the established knowledge base is changing in all areas of the labour market (Alvesson, 2004). Work and society are dominated by commitment to demands for high levels of demonstrable accountability......, cost-efficiency and measurable quality. Thus, today, evidence-based practice has become an expectation and fashion, often used to emphasize the grounding of practice in research based knowledge that provides measurable evidence for best practice. But at the same time, there is a growing distrust...

  2. The two faces of medical evidence.

    Science.gov (United States)

    Adler, Rolf H; von Uexküll, Thure; Herrmann, Jörg M

    2002-07-27

    The dictionary definition of "evidence" is given. The meaning of evidence in the history of science is described. Clinical examples are presented to illustrate different aspects of evidence, i.e. the mechanistic versus the semiotic points of view. Evidence is explained in the light of constructivism, and suggestions are presented as to how evidence can be applied in a biopsychosocial model of medicine.

  3. Coarticulatory evidence in stuttered disfluencies

    Science.gov (United States)

    Arbisi-Kelm, Timothy

    2005-09-01

    While the disfluencies produced in stuttered speech surface at a significantly higher rate than those found in normal speech, it is less clear from the previous stuttering literature how exactly these disfluency patterns might differ in kind [Wingate (1988)]. One tendency found in normal speech is for disfluencies to remove acoustic evidence of coarticulation patterns [Shriberg (1999)]. This appears attributable to lexical search errors which prevent a speaker from accessing a word's phonological form; that is, coarticulation between words will fail to occur when segmental material from the following word is not retrieved. Since stuttering is a disorder which displays evidence of phonological but not lexical impairment, it was predicted that stuttered disfluencies would differ from normal errors in that the former would reveal acoustic evidence of word transitions. Eight speakers four stutterers and four control subjects participated in a narrative-production task, spontaneously describing a picture book. Preliminary results suggest that while both stutterers and controls did produce similar rates of disfluencies occurring without coarticulatory evidence, only the stutterers regularly produced disfluencies reflecting this transitional evidence. These results support the argument that disfluencies proper to stuttering result from a phonological deficit, while normal disfluencies are generally lexically based.

  4. Epidemiological evidence in forensic pharmacovigilance.

    Science.gov (United States)

    Persaud, Nav; Healy, David

    2012-01-01

    Until recently epidemiological evidence was not regarded as helpful in determining cause and effect. It generated associations that then had to be explained in terms of bio-mechanisms and applied to individual patients. A series of legal cases surrounding possible birth defects triggered by doxylamine (Bendectin) and connective tissue disorders linked to breast implants made it clear that in some instances epidemiological evidence might have a more important role, but the pendulum swung too far so that epidemiological evidence has in recent decades been given an unwarranted primacy, partly perhaps because it suits the interests of certain stakeholders. Older and more recent epidemiological studies on doxylamine and other antihistamines are reviewed to bring out the ambiguities and pitfalls of an undue reliance on epidemiological studies.

  5. [Expert Evidence in Whiplash Injury].

    Science.gov (United States)

    Bucur, Florin M; Schwarze, Martin; Schiltenwolf, Marcus

    2017-01-12

    The assessment of cervical spine injuries is not a problem - provided full evidence of primary physical damage can be ensured. MRI examinations of the cervical spine carried out soon after the accident provide the best evidence. The assessment is more difficult if only clinical abnormalities are documented by the doctors after the accident in the diagnosis of cervical spine distortion, as functional results of this type are not specific and are also common in the general population. The legal rules of evidence must be taken into account in the summary assessment of the consequences of cervical spine injuries. Testing schemes are available which allow structured assessment of cervical spine injuries and help to avoid incorrect assessments.

  6. Evidence in the learning organization

    Directory of Open Access Journals (Sweden)

    Umscheid Craig A

    2009-03-01

    Full Text Available Abstract Background Organizational leaders in business and medicine have been experiencing a similar dilemma: how to ensure that their organizational members are adopting work innovations in a timely fashion. Organizational leaders in healthcare have attempted to resolve this dilemma by offering specific solutions, such as evidence-based medicine (EBM, but organizations are still not systematically adopting evidence-based practice innovations as rapidly as expected by policy-makers (the knowing-doing gap problem. Some business leaders have adopted a systems-based perspective, called the learning organization (LO, to address a similar dilemma. Three years ago, the Society of General Internal Medicine's Evidence-based Medicine Task Force began an inquiry to integrate the EBM and LO concepts into one model to address the knowing-doing gap problem. Methods During the model development process, the authors searched several databases for relevant LO frameworks and their related concepts by using a broad search strategy. To identify the key LO frameworks and consolidate them into one model, the authors used consensus-based decision-making and a narrative thematic synthesis guided by several qualitative criteria. The authors subjected the model to external, independent review and improved upon its design with this feedback. Results The authors found seven LO frameworks particularly relevant to evidence-based practice innovations in organizations. The authors describe their interpretations of these frameworks for healthcare organizations, the process they used to integrate the LO frameworks with EBM principles, and the resulting Evidence in the Learning Organization (ELO model. They also provide a health organization scenario to illustrate ELO concepts in application. Conclusion The authors intend, by sharing the LO frameworks and the ELO model, to help organizations identify their capacities to learn and share knowledge about evidence-based practice

  7. Current evidence for osteoarthritis treatments.

    Science.gov (United States)

    Anandacoomarasamy, Ananthila; March, Lyn

    2010-02-01

    Osteoarthritis (OA) is the most common form of arthritis and the leading cause of chronic disability among older people. The burden of the disease is expected to rise with an aging population and the increasing prevalence of obesity. Despite this, there is as yet no cure for OA. However, in recent years, a number of potential therapeutic advances have been made, in part due to improved understanding of the underlying pathophysiology. This review provides the current evidence for symptomatic management of OA including nonpharmacological, pharmacological and surgical approaches. The current state of evidence for disease-modifying therapy in OA is also reviewed.

  8. Evidence for homeopathy in childbirth.

    Science.gov (United States)

    Smith, Valerie

    2013-09-01

    Homeopathy has been described as 'a fascinating field of study and a natural complement to the science and art of midwifery' (Brennan 1999: 298). Supported by the Royal College of Midwives' (RCM) campaign for normal birth and resulting from a growing desire by women to avoid conventional medicine, the use of homeopathic remedies in childbirth is gaining momentum. Midwives are ideally positioned to discuss homeopathy with women. To enable informed discussions, however, midwives must have evidence on homeopathy use. This article explores the evidence on homeopathy use in childbirth.

  9. Scientific Evidence for Hydrostatic Shock

    CERN Document Server

    Courtney, Michael

    2008-01-01

    This paper reviews the scientific support for a ballistic pressure wave radiating outward from a penetrating projectile and causing injury and incapacitation. This phenomenon is known colloquially as "hydrostatic shock." The idea apparently originates with Col. Frank Chamberlin, a World War II trauma surgeon and wound ballistics researcher. The paper reviews claims that hydrostatic shock is a myth and considers supporting evidence through parallels with blast, describing the physics of the pressure wave, evidence for remote cerebral effects, and remote effects in the spine and other internal organs. Finally, the review considers the levels of energy transfer required for the phenomenon to be readily observed.

  10. Evidence-Based Psychological Assessment.

    Science.gov (United States)

    Bornstein, Robert F

    2016-11-03

    In recent years there has been increasing emphasis on evidence-based practice in psychology (EBPP), and as is true in most health care professions, the primary focus of EBPP has been on treatment. Comparatively little attention has been devoted to applying the principles of EBPP to psychological assessment, despite the fact that assessment plays a central role in myriad domains of empirical and applied psychology (e.g., research, forensics, behavioral health, risk management, diagnosis and classification in mental health settings, documentation of neuropsychological impairment and recovery, personnel selection and placement in organizational contexts). This article outlines the central elements of evidence-based psychological assessment (EBPA), using the American Psychological Association's tripartite definition of EBPP as integration of the best available research with clinical expertise in the context of patient characteristics, culture, and preferences. After discussing strategies for conceptualizing and operationalizing evidence-based testing and evidence-based assessment, 6 core skills and 3 meta-skills that underlie proficiency in psychological assessment are described. The integration of patient characteristics, culture, and preferences is discussed in terms of the complex interaction of patient and assessor identities and values throughout the assessment process. A preliminary framework for implementing EBPA is offered, and avenues for continued refinement and growth are described.

  11. Evidence-based playground design

    DEFF Research Database (Denmark)

    Refshauge, Anne Dahl; Stigsdotter, Ulrika K.; Lamm, Bettina;

    2015-01-01

    This paper develops, explores and evaluates an evidence-based approach to playground design, with a public park playground (playlab Cph) in Copenhagen as a case study. In the increasingly urbanised world, park playgrounds are valuable places that support healthy child development by providing opp...

  12. Bayesian Evidence and Model Selection

    CERN Document Server

    Knuth, Kevin H; Malakar, Nabin K; Mubeen, Asim M; Placek, Ben

    2014-01-01

    In this paper we review the concept of the Bayesian evidence and its application to model selection. The theory is presented along with a discussion of analytic, approximate and numerical techniques. Application to several practical examples within the context of signal processing are discussed.

  13. Evidence-Based IT Development

    DEFF Research Database (Denmark)

    Simonsen, Jesper; Hertzum, Morten

    2005-01-01

    Evidence-based IT development aims at developing a new commercial contract model for IT projects where the cus-tomers payment is dependent on measurable effects of using the vendors system. The idea is to establish a strategic part-nership in which customer and IT vendor share the responsi-bility...

  14. Voluntary disclosure: Evidence from UK

    NARCIS (Netherlands)

    N.S. Zourarakis (Nicolaos)

    2009-01-01

    textabstractThis paper investigates the voluntary disclosure of Intellectual Capital (IC) of British firms and provides some evidence on an unexplored area of the literature; that of the association of Corporate Governance (CG) with IC disclosure. Inconsistent with expectations, the results show tha

  15. Evidence-Based Radiology (EBR

    Directory of Open Access Journals (Sweden)

    Mansoor Fatehi

    2009-01-01

    Full Text Available   "nRecent increase in scientific advancements has led to inability to cover many scientific data and remain “up-to-date”. Nowadays doubling time of scientific data production is remarkably reduced, so that there is no adequate time to find this information and it seems inevitable to use resources which periodically assess most published papers or web-based data in that particular field to finally provide evidence-based knowledge, namely “Evidence-Based Medicine (EBM” in medical sciences. EBM is the systematic, scientific and explicit use of current best evidence in making decisions about the care of individual patients. Medical practice is largely based on clinical anecdotes, uncontrolled investigations and expert opinion. In radiology, the situation is especially problematic. "nRadiologists require to be able to evaluate studies in the literature, i.e., how reliable is this information and does it apply to patients in the radiologist’s practice? "nWe may find that our textbooks are out of date, guidelines are non-specific and there are conflicting "nor unreliable reports in the literature. Expert opinions vary from centre to centre. "nWhen we go to the literature ourselves, the first problem we encounter is the volume of literature being published and the next (at least for most of us is lack of training in how to separate good studies from weak ones. Evidence-based radiology (EBR can be a solution. "nThere are 5 steps in applying an approach as a solution: "n1. Ask - Information needs relevant to individual patients are converted into ‘answerable’ or ‘focused’ questions. "n2. Search - A comprehensive literature search is performed to find the best evidence to help answer these questions. "n3. Appraise - The evidence must then be critically appraised, in an explicit and structured manner, in order to establish its validity, reliability and usefulness in practice. "n4. Apply - The results of this critical appraisal are then

  16. Evidence, Ethics & Social Policy Dilemmas

    Directory of Open Access Journals (Sweden)

    Steven I. Miller

    1993-07-01

    Full Text Available Within the philosophy of the social sciences, the relationship between evidence, ethics, and social policy is in need of further analysis. The present paper is an attempt to argue that while important social policies can, and perhaps ought to be, grounded in ethical theory, they are seldom articulated in this fashion due to the ambiguity surrounding the "evidence condition." Using a consequentialist-utilitarian framework, and a case study of a policy dilemma, the authors analyze the difficulties associated with resolving policy-based dilemmas which must appeal to evidential support as a justification for an ethical stand. Implication for the relevance of ethics to social policy formulation are discussed in detail.

  17. Learning Styles: Concepts and Evidence.

    Science.gov (United States)

    Pashler, Harold; McDaniel, Mark; Rohrer, Doug; Bjork, Robert

    2008-12-01

    The term "learning styles" refers to the concept that individuals differ in regard to what mode of instruction or study is most effective for them. Proponents of learning-style assessment contend that optimal instruction requires diagnosing individuals' learning style and tailoring instruction accordingly. Assessments of learning style typically ask people to evaluate what sort of information presentation they prefer (e.g., words versus pictures versus speech) and/or what kind of mental activity they find most engaging or congenial (e.g., analysis versus listening), although assessment instruments are extremely diverse. The most common-but not the only-hypothesis about the instructional relevance of learning styles is the meshing hypothesis, according to which instruction is best provided in a format that matches the preferences of the learner (e.g., for a "visual learner," emphasizing visual presentation of information). The learning-styles view has acquired great influence within the education field, and is frequently encountered at levels ranging from kindergarten to graduate school. There is a thriving industry devoted to publishing learning-styles tests and guidebooks for teachers, and many organizations offer professional development workshops for teachers and educators built around the concept of learning styles. The authors of the present review were charged with determining whether these practices are supported by scientific evidence. We concluded that any credible validation of learning-styles-based instruction requires robust documentation of a very particular type of experimental finding with several necessary criteria. First, students must be divided into groups on the basis of their learning styles, and then students from each group must be randomly assigned to receive one of multiple instructional methods. Next, students must then sit for a final test that is the same for all students. Finally, in order to demonstrate that optimal learning requires

  18. Leading teaming: Evidence from Jazz

    OpenAIRE

    Araújo, Francisco Maria Trigo da Roza Carvalho

    2013-01-01

    A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA – School of Business and Economics In this research we conducted qualitative analysis to study the team dynamics of jazz combos in order to explore deeper the leadership behaviors in a creative environment where teaming occurs. We found evidence of a dual leader, one that shifts his/her role between ‘leader as leader’ and ‘leader as member’, embracing both leaderfulness an...

  19. Evidence for a nonplanar amplituhedron

    Science.gov (United States)

    Bern, Zvi; Herrmann, Enrico; Litsey, Sean; Stankowicz, James; Trnka, Jaroslav

    2016-06-01

    The scattering amplitudes of planar mathcal{N} = 4 super-Yang-Mills exhibit a number of remarkable analytic structures, including dual conformal symmetry and logarithmic singularities of integrands. The amplituhedron is a geometric construction of the integrand that incorporates these structures. This geometric construction further implies the amplitude is fully specified by constraining it to vanish on spurious residues. By writing the amplitude in a dlog basis, we provide nontrivial evidence that these analytic properties and "zero conditions" carry over into the nonplanar sector. This suggests that the concept of the amplituhedron can be extended to the nonplanar sector of mathcal{N} = 4 super-Yang-Mills theory.

  20. Evidence for a Nonplanar Amplituhedron

    CERN Document Server

    Bern, Zvi; Litsey, Sean; Stankowicz, James; Trnka, Jaroslav

    2015-01-01

    The scattering amplitudes of planar N = 4 super-Yang-Mills exhibit a number of remarkable analytic structures, including dual conformal symmetry and logarithmic singularities of integrands. The amplituhedron is a geometric construction of the integrand that incorporates these structures. This geometric construction further implies the amplitude is fully specified by constraining it to vanish on spurious residues. By writing the amplitude in a dlog basis, we provide nontrivial evidence that these analytic properties and "zero conditions" carry over into the nonplanar sector. This suggests that the concept of the amplituhedron can be extended to the the nonplanar sector of N = 4 super-Yang-Mills theory.

  1. Conditionally Optimal Weights of Evidence

    Institute of Scientific and Technical Information of China (English)

    Stephan Morgenthaler; Robert G. Staudte

    2005-01-01

    A weight of evidence is a calibrated statistic whose wlues in [0, 1] indicate the degree of agreement between the data and either of two hypothesis, one being treated as the null (H0) and the other as the alternative (H1). A wlue of zero means perfect agreement with the null, whereas a value of one means perfect agreement with the alternative. The optimality we consider is minimal mean squared error (MSE) under the alternative while keeping the MSE under the null below a fixed bound. This paper studies such statistics from a conditional point of view, in particular for location and scale models.

  2. Digital forensics digital evidence in criminal investigations

    CERN Document Server

    Marshall, Angus McKenzie

    2009-01-01

    The vast majority of modern criminal investigations involve some element of digital evidence, from mobile phones, computers, CCTV and other devices. Digital Forensics: Digital Evidence in Criminal Investigations provides the reader with a better understanding of how digital evidence complements "traditional" scientific evidence and examines how it can be used more effectively and efficiently in a range of investigations. Taking a new approach to the topic, this book presents digital evidence as an adjunct to other types of evidence and discusses how it can be deployed effectively in s

  3. Exogenous glutamine: the clinical evidence.

    Science.gov (United States)

    Bongers, Thomas; Griffiths, Richard D; McArdle, Anne

    2007-09-01

    We know that critically ill patients suffering from undernutrition with a limited nutritional reserve have a poorer outcome. Furthermore, having a low body mass index has been shown to be an independent predictor of excess mortality in multiple organ failure. Therefore, nutritional support has gained increasing interest in critical illness with the hope of preventing or attenuating the effects of malnutrition. A negative nitrogen balance is the characteristic metabolic feature in critical illness, with the major protein loss derived from skeletal muscle. In particular, glutamine concentrations are rapidly reduced in plasma and muscle. Over the last 20 yrs or so, increasing evidence is emerging to support the use of glutamine supplementation in critical illness. Clinical trials have found a mortality and morbidity advantage with glutamine supplementation. The advantage appears to be greater the more glutamine is given and greater again when given parenterally. Various modes of action have been postulated. Glutamine seems to have an effect on the immune system, antioxidant status, glucose metabolism, and heat shock protein response. However, the benefit of exogenous glutamine on morbidity and mortality is not universally accepted. This review critically appraises the current clinical evidence regarding glutamine supplementation in critical illness.

  4. Pragmatics in aphasia: crosslinguistic evidence.

    Science.gov (United States)

    Wulfeck, B; Bates, E; Juarez, L; Opie, M; Friederici, A; MacWhinney, B; Zurif, E

    1989-01-01

    Previous research suggests that English Broca's and Wernicke's aphasics retain sensitivity to pragmatic factors governing forms of reference, in particular the ability to choose lexical expressions that convey givenness and newness of information. The present study investigates the generality of this phenomenon across patients and language types. Normal and aphasic speakers of English, German, and Italian described nine picture triplets in which one element varied while the others remained constant. Dependent variables included lexicalization versus ellipsis, pronominalization, and definite and indefinite article use. For a subset of German and Italian patients, data were compared to performance in a biographical interview. Results indicate that (a) the pragmatics of reference are preserved in both Broca's and Wernicke's aphasics, despite syndrome-specific problems in retrieving content words and/or closed-class grammatical elements, and (b) certain language-specific patterns of reference are also preserved, including crosslinguistic differences in subject omission. Differences between picture description and the biographical interview reinforce this conclusion. Evidence for the preservation of pragmatics in aphasis is not surprising in its own right, but evidence for the sparing of language-specific relations among pragmatic, lexical, and morphosyntactic patterns can be used to argue against any strong view of grammatical impairment as a disconnection syndrome and/or a loss of grammatical competence. Instead, these data support theories in which grammatical impairment is viewed as a performance deficit.

  5. Authentication of digital video evidence

    Science.gov (United States)

    Beser, Nicholas D.; Duerr, Thomas E.; Staisiunas, Gregory P.

    2003-11-01

    In response to a requirement from the United States Postal Inspection Service, the Technical Support Working Group tasked The Johns Hopkins University Applied Physics Laboratory (JHU/APL) to develop a technique tha will ensure the authenticity, or integrity, of digital video (DV). Verifiable integrity is needed if DV evidence is to withstand a challenge to its admissibility in court on the grounds that it can be easily edited. Specifically, the verification technique must detect additions, deletions, or modifications to DV and satisfy the two-part criteria pertaining to scientific evidence as articulated in Daubert et al. v. Merrell Dow Pharmaceuticals Inc., 43 F3d (9th Circuit, 1995). JHU/APL has developed a prototype digital video authenticator (DVA) that generates digital signatures based on public key cryptography at the frame level of the DV. Signature generation and recording is accomplished at the same time as DV is recorded by the camcorder. Throughput supports the consumer-grade camcorder data rate of 25 Mbps. The DVA software is implemented on a commercial laptop computer, which is connected to a commercial digital camcorder via the IEEE-1394 serial interface. A security token provides agent identification and the interface to the public key infrastructure (PKI) that is needed for management of the public keys central to DV integrity verification.

  6. 24 CFR 26.47 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... PROCEDURES Hearings Pursuant to the Administrative Procedure Act Hearings § 26.47 Evidence. The ALJ shall... evidence if its probative value is substantially outweighed by confusion of the issues, or...

  7. Science and evidence: separating fact from fiction.

    Science.gov (United States)

    Hess, Dean R

    2013-10-01

    Evidence-based medicine (EBM) is the integration of individual clinical expertise with the best available research evidence from systematic research and the patient's values and expectations. A hierarchy of evidence can be used to assess the strength upon which clinical decisions are made. The efficient approach to finding the best evidence is to identify systematic reviews or evidence-based clinical practice guidelines. Respiratory therapies that evidence supports include noninvasive ventilation for appropriately selected patients, lung-protective ventilation, and ventilator discontinuation protocols. Evidence does not support use of weaning parameters, albuterol for ARDS, and high frequency oscillatory ventilation for adults. Therapy with equivocal evidence includes airway clearance, selection of an aerosol delivery device, and PEEP for ARDS. Although all tenets of EBM are not universally accepted, the principles of EBM nonetheless provide a valuable approach to respiratory care practice.

  8. ON EVIDENCE: APPROACH FROM THE PHILOSOPHICAL HERMENEUTICS

    Directory of Open Access Journals (Sweden)

    Arturo García Rillo

    2015-06-01

    Full Text Available In order to make the term analytical evidence to reveal the original meaning of its application to account for hermeneutical situations in the world of life, the study was conducted from philosophical hermeneutics stating the following: viewpoint, understanding horizon and fusion of horizons. In the viewpoint uses of evidence are described. The horizon of understanding traces the history of the concept of evidence highlighting the perspective of Husserl. In the fusion of horizons evidence described in three levels of reality: perceived (evidence from beliefs, known (evidence from knowledge and constructed (deliberative evidence. We conclude that the historicity of the world allows rehabilitate the tradition and gives meaning to the evidence as the fact that it gets in the eyes through the original experience of hermeneutics situation that exists in practice.

  9. Evidence for Ancient Mesoamerican Earthquakes

    Science.gov (United States)

    Kovach, R. L.; Garcia, B.

    2001-12-01

    Evidence for past earthquake damage at Mesoamerican ruins is often overlooked because of the invasive effects of tropical vegetation and is usually not considered as a casual factor when restoration and reconstruction of many archaeological sites are undertaken. Yet the proximity of many ruins to zones of seismic activity would argue otherwise. Clues as to the types of damage which should be soughtwere offered in September 1999 when the M = 7.5 Oaxaca earthquake struck the ruins of Monte Alban, Mexico, where archaeological renovations were underway. More than 20 structures were damaged, 5 of them seriously. Damage features noted were walls out of plumb, fractures in walls, floors, basal platforms and tableros, toppling of columns, and deformation, settling and tumbling of walls. A Modified Mercalli Intensity of VII (ground accelerations 18-34 %b) occurred at the site. Within the diffuse landward extension of the Caribbean plate boundary zone M = 7+ earthquakes occur with repeat times of hundreds of years arguing that many Maya sites were subjected to earthquakes. Damage to re-erected and reinforced stelae, walls, and buildings were witnessed at Quirigua, Guatemala, during an expedition underway when then 1976 M = 7.5 Guatemala earthquake on the Motagua fault struck. Excavations also revealed evidence (domestic pttery vessels and skeleton of a child crushed under fallen walls) of an ancient earthquake occurring about the teim of the demise and abandonment of Quirigua in the late 9th century. Striking evidence for sudden earthquake building collapse at the end of the Mayan Classic Period ~A.D. 889 was found at Benque Viejo (Xunantunich), Belize, located 210 north of Quirigua. It is argued that a M = 7.5 to 7.9 earthquake at the end of the Maya Classic period centered in the vicinity of the Chixoy-Polochic and Motagua fault zones cound have produced the contemporaneous earthquake damage to the above sites. As a consequences this earthquake may have accelerated the

  10. Evidence-based practice of periodontics.

    Science.gov (United States)

    Cobb, Charles M; MacNeill, Simon R; Satheesh, Keerthana

    2010-01-01

    Evidence-based practice involves complex and conscientious decision making based not only on the available evidence but also on patient characteristics, situations, and preferences. It recognizes that care is individualized and ever-changing and involves uncertainties and probabilities. The specialty of periodontics has abundant high-level evidence upon which treatment decisions can be determined. This paper offers a brief commentary and overview of the available evidence commonly used in the private practice of periodontics.

  11. Toxicological evidence in forensic pharmacology.

    Science.gov (United States)

    Ferner, R E

    2012-01-01

    Laboratory evidence of the presence and concentration of a drug in a person who has come to harm is often helpful in forensic pharmacology, and may be crucial. However, its value depends on two critical interpretations by the expert. First, the expert must make a careful analysis of the relationship between the results as measured in the sample and the drug in the patient at the time that harm occurred. That is especially difficult with post-mortem samples. Secondly, the expert must syntheses the laboratory information with the available clinical history and clinical or pathological findings. Even in the most favourable circumstances, when the sample is correctly obtained, identified, and analyzed, it can be hard to say that beyond reasonable doubt a given concentration had a given effect.

  12. Reconsidering Subextraction: Evidence from Spanish

    Directory of Open Access Journals (Sweden)

    Ignacio Bosque

    2014-11-01

    Full Text Available This paper argues that so-called subextraction (e.g., Whoi has John seen a picture of ti ?; cf. Corver 2006 for recent discussion does not involve movement of a wh-phrase to a DP internal escape hatch position before reaching the CP layer. Instead, we claim that apparently subextracted wh-phrases are actually direct dependents of the verb after a process of reanalysis (or readjustment; cf. Chomsky 1977, Kayne 2002 applies. Our proposal rethinks an old (Bach & Horn 1976 idea, reframes it in modern terms and argues against the cyclic status of DPs (cf. Bruening 2009, Leu 2008, Ott 2008, and references therein, by leaning on new evidence from Spanish. The non-cyclic status of DPs is a fairly standard idea ever since clausal properties were assumed to hold for nominal domains (cf. Chomsky 1970, Brame 1982, Abney 1987, and much subsequent literature.

  13. Evidence-based Science Communication

    Science.gov (United States)

    Kahan, D.

    2012-12-01

    This presentation will describe a concrete strategy for bridging the gap between the *science* of science communication and the practice of it. In recent years, social scientists have made substantial progress in identifying the psychological influences that shape public receptivity to scientific information relating to climate change and other public policy issues. That work, however, has consisted nearly entirely of laboratory experiments and public opinion surveys; these methods identify general mechanisms of information processing but do not yield concrete prescriptions for communication in field settings. In order to integrate the findings of the science of science communication with the practice of it, field communication must now be made into a meaningful site of science communication research. "Evidence-based science communication" will involve collaborative work between social scientists and practitioners aimed at formulating and testing scientifically informed communication strategies in real-world contexts.

  14. Innovation Promises and Evidence Realities.

    Science.gov (United States)

    Maschke, Karen J

    2016-09-01

    Over the past year media outlets and scientific and bioethics journals have reported about several medical and scientific innovations touted as having the potential to fundamentally change not only how diseases and disorders are diagnosed and treated but even how to alter the genomes of future generations. The purported "miracle" blood-testing technology of Theranos and the potential use of the genome editing technology CRISPR-Cas9 to modify human and nonhuman organisms reflect dramatic advances in scientific understanding about the biological mechanisms of humans and other living organisms. Yet evidence about whether these and other innovative biomedical technologies are safe and effective and lead to improved health outcomes for patients young and old is often in dispute. How to assess the safety and effectiveness of innovative biomedical technologies, who should be involved in that effort, and how to define risks and benefits of those technologies are questions at the intersection of values, interests, and politics.

  15. Evidence of the Big Fix

    CERN Document Server

    Hamada, Yuta; Kawana, Kiyoharu

    2014-01-01

    We give an evidence of the Big Fix. The theory of wormholes and multiverse suggests that the parameters of the Standard Model are fixed in such a way that the total entropy at the late stage of the universe is maximized, which we call the maximum entropy principle. In this paper, we discuss how it can be confirmed by the experimental data, and we show that it is indeed true for the Higgs vacuum expectation value $v_{h}$. We assume that the baryon number is produced by the sphaleron process, and that the current quark masses, the gauge couplings and the Higgs self coupling are fixed when we vary $v_{h}$. It turns out that the existence of the atomic nuclei plays a crucial role to maximize the entropy. This is reminiscent of the anthropic principle, however it is required by the fundamental low in our case.

  16. Evidence of the big fix

    Science.gov (United States)

    Hamada, Yuta; Kawai, Hikaru; Kawana, Kiyoharu

    2014-06-01

    We give an evidence of the Big Fix. The theory of wormholes and multiverse suggests that the parameters of the Standard Model are fixed in such a way that the total entropy at the late stage of the universe is maximized, which we call the maximum entropy principle. In this paper, we discuss how it can be confirmed by the experimental data, and we show that it is indeed true for the Higgs vacuum expectation value vh. We assume that the baryon number is produced by the sphaleron process, and that the current quark masses, the gauge couplings and the Higgs self-coupling are fixed when we vary vh. It turns out that the existence of the atomic nuclei plays a crucial role to maximize the entropy. This is reminiscent of the anthropic principle, however it is required by the fundamental law in our case.

  17. Evidence-Based Practice: Management of Vertigo

    OpenAIRE

    Nguyen-Huynh, Anh T.

    2012-01-01

    The article focuses on the evidence basis for the management of benign paroxysmal positional vertigo (BPPV), the most common diagnosis of vertigo in both primary care and subspecialty settings. Like all articles in this compilation of evidence-based practice, an overview is presented along with evidence based clinical assessment, diagnosis, and management. Summaries of differential diagnosis of vertigo and outcomes are presented.

  18. Justified Belief and the Topology of Evidence

    NARCIS (Netherlands)

    Baltag, A.; Bezhanishvili, N.; Özgün, A.; Smets, S.J.L.; Väänänen, J.; Hirvonen, Å.; de Queiroz, R.

    2016-01-01

    We introduce a new topological semantics for evidence, evidence-based justifications, belief and knowledge. This setting builds on the evidence model framework of van Benthem and Pacuit, as well as our own previous work on (a topological semantics for) Stalnaker’s doxastic-epistemic axioms. We prove

  19. Evidence-based practice voor verpleegkundigen

    NARCIS (Netherlands)

    Cox, C.M.M.; Louw, D.C.P. de; Verhoef, J.; Kuiper, C.

    2004-01-01

    Om goede en verantwoorde zorg te kunnen bieden, streeft de verpleegkundige naar evidence-based practice. Evidence-based practice is het gewetensvol, expliciet en oordeelkundig gebruik van het huidige beste bewijsmateriaal om beslissingen te nemen voor individuele patiënten. De praktijk van evidence-

  20. Using Science as Evidence in Public Policy

    Science.gov (United States)

    Prewitt, Kenneth, Ed.; Schwandt, Thomas A., Ed.; Straf, Miron L., Ed.

    2012-01-01

    "Using Science as Evidence in Public Policy" encourages scientists to think differently about the use of scientific evidence in policy making. This report investigates why scientific evidence is important to policy making and argues that an extensive body of research on knowledge utilization has not led to any widely accepted explanation…

  1. 21 CFR 1404.900 - Adequate evidence.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Adequate evidence. 1404.900 Section 1404.900 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 1404.900 Adequate evidence. Adequate evidence means information sufficient...

  2. The Electronic Evidence in Trial Proceedings

    Directory of Open Access Journals (Sweden)

    Monica Pocora

    2015-05-01

    Full Text Available This paper will consider theoretical and practical issues which arise in trial proceedings, throughout the virtual presence of persons involved. The EU Convention of 2000 provide the legal base for the use of video conference. In most jurisdictions, all forms of evidence is admissible, subject to rules relating to the exclusion of evidence because of improper actions or because the inclusion of the evidence would be unfair to the defendant. There is a difference between the admissibility of the evidence and laying the correct foundations before the evidence can be admitted.

  3. Evidence and guidelines in otorhinolaryngology: the merits of evidence-based case reports

    NARCIS (Netherlands)

    Aarts, M.C.J.

    2012-01-01

    Evidence-based medicine refers to the conscientious, explicit and judicious use of the current best evidence to support decision making at point of care. To facilitate the transition of evidence into daily practice several evidence-based otorhinolaryngology guidelines have been developed. In this th

  4. Mercury and autism: accelerating evidence?

    Science.gov (United States)

    Mutter, Joachim; Naumann, Johannes; Schneider, Rainer; Walach, Harald; Haley, Boyd

    2005-10-01

    The causes of autism and neurodevelopmental disorders are unknown. Genetic and environmental risk factors seem to be involved. Because of an observed increase in autism in the last decades, which parallels cumulative mercury exposure, it was proposed that autism may be in part caused by mercury. We review the evidence for this proposal. Several epidemiological studies failed to find a correlation between mercury exposure through thimerosal, a preservative used in vaccines, and the risk of autism. Recently, it was found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. Normal function of MS is crucial in biochemical steps necessary for brain development, attention and production of glutathione, an important antioxidative and detoxifying agent. Repetitive doses of thimerosal leads to neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequently, autistic children have significantly decreased level of reduced glutathione. Promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites.

  5. Museums? Evidence from two Countries

    Directory of Open Access Journals (Sweden)

    Azilah Kasim

    2014-12-01

    Full Text Available This paper provides evidence on Young Adults’ motivations for visiting and not visiting museums. Using purposive sampling, self-administered questionnaires were distributed to respondents in Kedah, Malaysia and Eskisehir, Turkey. Both Kedah and Eskisehir share one similarity – they both have many museums. The findings revealed that in both study contexts, young people tended to visit museums for practical reasons such as to help them prepare homework or a project. They also visit for intrinsic reasons such as to satisfy their curiosity. Both samples also illustrate Davies (2001 contention that awareness is an important precursor to potential visits. On the other hand, both samples are different in reasons for not visiting. While young people in Eskisehir cite emotional reasons for deciding not to visit, young people in Kedah offered more practical ones such as lack of time and interest, or more interested in other activities. The study findings are useful for understanding reasons behind the generally low museum visits among youth. Several managerial implications of the study were also proposed.

  6. Level of evidence gap in orthopedic research.

    Science.gov (United States)

    Baldwin, Keith D; Bernstein, Joseph; Ahn, Jaimo; McKay, Scott D; Sankar, Wudbhav N

    2012-09-01

    Level of evidence is the most widely used metric for the quality of a publication, but instances exist in which a Level I study is neither feasible nor desirable. The goal of this study was to evaluate the level of evidence gap in current orthopedic research, which the authors defined as the disparity between the level of evidence that would be required to optimally answer the primary research question and the level of evidence that was actually used. Five orthopedic surgeons (K.D.B., J.B., J.A., S.D.M., W.N.S.) evaluated blinded articles from the first 6 months of 2010 in the Journal of Bone and Joint Surgery (American Volume) (JBJS-Am), classifying the study type and design and extracting a primary research question from each article. Each evaluator then defined the study type and method, along with the level of evidence that would ideally be used to address the primary research question. The level of evidence gap was then calculated by subtracting the actual level of evidence of the manuscript from the level of evidence of the idealized study. Of the 64 JBJS-Am manuscripts eligible for analysis, the average level of evidence was between Level II and III (mean, 2.73). The average level of evidence gap was 1.06 compared with the JBJS-Am-designated level of evidence and 1.28 compared with the evaluators' assessment. Because not all questions require Level I studies, level of evidence alone may not be the best metric for the quality of orthopedic surgery literature. Instead, the authors' concept of a level of evidence gap may be a better tool for assessing the state of orthopedic research publications.

  7. The expression and interpretation of uncertain forensic science evidence: verbal equivalence, evidence strength, and the weak evidence effect.

    Science.gov (United States)

    Martire, Kristy A; Kemp, Richard I; Watkins, Ian; Sayle, Malindi A; Newell, Ben R

    2013-06-01

    Standards published by the Association of Forensic Science Providers (2009, Standards for the formulation of evaluative forensic science expert opinion, Science & Justice, Vol. 49, pp. 161-164) encourage forensic scientists to express their conclusions in the form of a likelihood ratio (LR), in which the value of the evidence is conveyed verbally or numerically. In this article, we report two experiments (using undergraduates and Mechanical Turk recruits) designed to investigate how much decision makers change their beliefs when presented with evidence in the form of verbal or numeric LRs. In Experiment 1 (N = 494), participants read a summary of a larceny trial containing inculpatory expert testimony in which evidence strength (low, moderate, high) and presentation method (verbal, numerical) varied. In Experiment 2 (N = 411), participants read the same larceny trial, this time including either exculpatory or inculpatory expert evidence that varied in strength (low, high) and presentation method (verbal, numerical). Both studies found a reasonable degree of correspondence in observed belief change resulting from verbal and numeric formats. However, belief change was considerably smaller than Bayesian calculations would predict. In addition, participants presented with evidence weakly supporting guilt tended to "invert" the evidence, thereby counterintuitively reducing their belief in the guilt of the accused. This "weak evidence effect" was most apparent in the verbal presentation conditions of both experiments, but only when the evidence was inculpatory. These findings raise questions about the interpretability of LRs by jurors and appear to support an expectancy-based account of the weak evidence effect.

  8. INFLATION AND FINANCIAL DEVELOPMENT: EVIDENCE

    Directory of Open Access Journals (Sweden)

    Emmanuel Nii Abbey

    2012-01-01

    Full Text Available The study examined the impact of inflation on financial development in Ghana using quarterly time series data (1990-2008. It was in line with the empirical works that provided support for the proposition that inflation affects financial development negatively. While price stability has been emphasized in the literature to be the best antidote in addressing the problem, recent evidence of disagreements on its definition and the ways to achieving it, coupled with, threshold effects between the two variables have questioned the precise link between the two variables and their acclaimed antidote. The study therefore made use of the Cointegration Approach the Granger Causality testing procedure suggested and the Conditional Least Squares technique to address these issues for the case of Ghana. The study established several statistically significant and economically meaningful relationships between the two variables. Pair-wise correlation analysis established a negative association between the two variables. In contrast, conflicting results were produced with regression analysis: the relationship between the two variables in the short run was established to be positive, while no relationship at all was established in the long run. Furthermore, a unidirectional causal link was established to be running from inflation to financial development; when the ratio of private sector credit to GDP and the market capitalization ratio were used as indicators for financial development. Lastly, threshold effects were observed in the inflation-financial development relation for inflation rates between 11-16% per annum. The study thus recommended the definition of price stability for inflation rates between 11-16% in support of financial development in Ghana. Additionally, it was recommended that the country should promote financial sector policies in a more holistic approach, as financial development does not granger cause inflation or inflationary pressures.

  9. Evidence-Based ACL Reconstruction

    Directory of Open Access Journals (Sweden)

    E. Carlos RODRIGUEZ-MERCHAN

    2015-01-01

    Full Text Available There is controversy in the literature regarding a number of topics related to anterior cruciate ligament (ACLreconstruction. The purpose of this article is to answer the following questions: 1 Bone patellar tendon bone (BPTB reconstruction or hamstring reconstruction (HR; 2 Double bundle or single bundle; 3 Allograft or authograft; 4 Early or late reconstruction; 5 Rate of return to sports after ACL reconstruction; 6 Rate of osteoarthritis after ACL reconstruction. A Cochrane Library and PubMed (MEDLINE search of systematic reviews and meta-analysis related to ACL reconstruction was performed. The key words were: ACL reconstruction, systematic reviews and meta-analysis. The main criteria for selection were that the articles were systematic reviews and meta-analysesfocused on the aforementioned questions. Sixty-nine articles were found, but only 26 were selected and reviewed because they had a high grade (I-II of evidence. BPTB-R was associated with better postoperative knee stability but with a higher rate of morbidity. However, the results of both procedures in terms of functional outcome in the long-term were similar. The double-bundle ACL reconstruction technique showed better outcomes in rotational laxity, although functional recovery was similar between single-bundle and double-bundle. Autograft yielded better results than allograft. There was no difference between early and delayed reconstruction. 82% of patients were able to return to some kind of sport participation. 28% of patients presented radiological signs of osteoarthritis with a follow-up of minimum 10 years.

  10. Evidence-based dentistry: a clinician's perspective.

    Science.gov (United States)

    Bauer, Janet; Spackman, Sue; Chiappelli, Francesco; Prolo, Paolo; Stevenson, Richard

    2006-07-01

    Evidence-based dentistry is a discipline that provides best, explicit-based evidence to dentists and their patients in shared decision-making. Currently, dentists are being trained and directed to adopt the role of translational researchers in developing evidence-based dental practices. Practically, evidence-based dentistry is not usable in its current mode for the provision of labor-intensive services that characterize current dental practice. The purpose of this article is to introduce a model of evidence-based dental practice. This model conceptualizes a team approach in explaining problems and solutions to change current dental practice. These changes constitute an evidence-based dental practice that involves the electronic chart, centralized database, knowledge management software, and personnel in optimizing effective oral health care to dental patients.

  11. Measuring statistical evidence using relative belief

    Directory of Open Access Journals (Sweden)

    Michael Evans

    2016-01-01

    Full Text Available A fundamental concern of a theory of statistical inference is how one should measure statistical evidence. Certainly the words “statistical evidence,” or perhaps just “evidence,” are much used in statistical contexts. It is fair to say, however, that the precise characterization of this concept is somewhat elusive. Our goal here is to provide a definition of how to measure statistical evidence for any particular statistical problem. Since evidence is what causes beliefs to change, it is proposed to measure evidence by the amount beliefs change from a priori to a posteriori. As such, our definition involves prior beliefs and this raises issues of subjectivity versus objectivity in statistical analyses. This is dealt with through a principle requiring the falsifiability of any ingredients to a statistical analysis. These concerns lead to checking for prior-data conflict and measuring the a priori bias in a prior.

  12. Expert Evidence and International Criminal Justice

    DEFF Research Database (Denmark)

    Appazov, Artur

    The book is a comprehensive narration of the use of expertise in international criminal trials offering reflection on standards concerning the quality and presentation of expert evidence. It analyzes and critiques the rules governing expert evidence in international criminal trials...... and the strategies employed by counsel and courts relying upon expert evidence and challenges that courts face determining its reliability. In particular, the author considers how the procedural and evidentiary architecture of international criminal courts and tribunals influences the courts' ability to meaningfully...... incorporate expert evidence into the rational fact-finding process. The book provides analysis of the unique properties of expert evidence as compared with other forms of evidence and the challenges that these properties present for fact-finding in international criminal trials. It draws conclusions about...

  13. Improving GRADE evidence tables part 2

    DEFF Research Database (Denmark)

    Langendam, Miranda; Carrasco-Labra, Alonso; Santesso, Nancy;

    2016-01-01

    OBJECTIVES: The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group has developed GRADE evidence profiles (EP) and summary of findings (SoF) tables to present evidence summaries in systematic reviews, clinical guidelines, and health technology assessments...... or control group risk) was often missing. For judgments about downgrading the quality of evidence, the percentage of informative explanations ranged between 41% (imprecision) and 79% (indirectness). CONCLUSION: We found that by and large explanations were informative but detected several areas...

  14. Modeling Forensic Evidence Systems Using Design Science

    OpenAIRE

    Armstrong, Colin; Armstrong, Helen

    2010-01-01

    International audience; This paper presents an overview of the application of design science research to the tactical management of forensic evidence processing. The opening discussion addresses the application of design science techniques to specific socio-technical information systems research in regard to processing forensic evidence. The discussion then presents the current problems faced by those dealing with evidence and a conceptual meta-model for a unified approach to forensic evidenc...

  15. What is the Best Evidence Medical Education?

    Directory of Open Access Journals (Sweden)

    Rasoul Masoomi

    2012-07-01

    Full Text Available Best Evidence Medical Education (BEME is defined as: “The implementation by teachers and educational bodies in their practice, of methods and approaches to education based on the best evidence available.” Five steps have been recognized in the practice of BEME. These are: framing the question, developing a search strategy, evaluating the evidence, implementing change and evaluating that change. In this paper, I described the concept of BEME, its steps, and challenges.

  16. Evidence: To see or not to see.

    Science.gov (United States)

    Eriksson, Katie

    2010-10-01

    "To see or not to see" is an allusion to the classical Shakespearean quotation "to be or not to be, that is the question." Evidence as a concept pertains to truth, reality, and being in the world; it involves seeing, realizing, making visible, and clothing thoughts into words. A new interpretation of the concept of evidence in caring science is presented in this column, based on the etymology of the concept and Gadamer's hermeneutical philosophy. Ontological or absolute evidence is based on being and the true reality that extends beyond the immediate reality. The truth, or the substance, lies concealed within the true reality. Evidence includes envisioning, seeing, knowing, attesting, and revising.

  17. New evidence: Why flowers self-fertilize?

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Studies on some Himalayan Sginger flowers have contributed novel empirical evidence to Charles Darwin's self-pollination theory, according to CAS researchers from the Xishuangbanna Tropical Botanical Garden.

  18. Careers in Forensics: Analysis, Evidence, and Law

    Science.gov (United States)

    Torpey, Elka Maria

    2009-01-01

    In legal proceedings, a case is only as strong as its evidence. And whether that evidence is strong depends, in large part, on the work of forensic specialists. The field of forensics is broad and involves many kinds of workers. Some of them are involved in crimesolving. Others, such as forensic social workers or forensic economists, help to…

  19. 42 CFR 3.540 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation... provided in Rule 408 of the Federal Rules of Evidence. (g) Evidence of crimes, wrongs, or acts other than... whether the crimes, wrongs, or acts occurred during the statute of limitations period applicable to...

  20. 34 CFR 33.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Evidence. 33.34 Section 33.34 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.34 Evidence. (a) The ALJ shall... danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or...

  1. 45 CFR 150.445 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or... will be inadmissible to the extent provided in the Federal Rules of Evidence. (g) Evidence of acts... penalty if those acts are used under §§ 150.317 and 150.323 of this part to consider the entity's...

  2. 29 CFR 22.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Evidence. 22.34 Section 22.34 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.34 Evidence. (a) The ALJ shall determine the... unfair prejudice, confusion of the issues, or by considerations of undue delay or needless...

  3. 45 CFR 160.540 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation... provided in Rule 408 of the Federal Rules of Evidence. (g) Evidence of crimes, wrongs, or acts other than... whether the crimes, wrongs, or acts occurred during the statute of limitations period applicable to...

  4. Shaping accountabilities for erroneously enacted environmental evidence

    DEFF Research Database (Denmark)

    Lippert, Ingmar

    Drawing on fieldwork in and around a transnational Fortune 50 company's "corporate social responsibility" unit, this paper opens up a range of situations that took part in enacting the company's evidence of its impact on global warming. This evidence was implicated in at least two significant mod...

  5. School Resegregation: A Synthesis of the Evidence

    Science.gov (United States)

    Glenn, William J.

    2012-01-01

    This article examines the evidence that supports and rebuts the claims of school resegregation. By examining both types of evidence and considering them complementary (James 1986; Kelly and Miller 1989), the author gives the reader a deeper understanding of the current trends in school segregation. First, the literature on the topic of school…

  6. Advancing Evidence in Preterm Neonatal Medicine

    Science.gov (United States)

    Donahue, Pamela K.; Robinson, Karen A.

    2010-01-01

    Few interventions and treatments for premature infants have undergone the rigors of a randomized controlled trial (RCT), the cornerstone of evidence-based healthcare. Multiple barriers in establishing a quality evidence base for the care of preterm infants are examined including the systematic exclusion of children from drug trials, vulnerability…

  7. 20 CFR 410.240 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... evidence may be submitted as part of a prescribed application form if the form provides for its inclusion... disability or death due to pneumoconiosis. For evidence requirements to support allegations of total disability or death due to pneumoconiosis; for the effect of the failure or refusal of an individual...

  8. Nonlocality as Evidence for a Multiverse Cosmology

    Science.gov (United States)

    Tipler, Frank J.

    We show that observations of quantum nonlocaltiy can be interpreted as purely local phenomena, provided one assumes that the cosmos is a multiverse. Conversely, the observation of quantum nonlocality can be interpreted as observation evidence for a multiverse cosmology, just as observation of the setting of the Sun can be interpreted as evidence for the Earth's rotation.

  9. Nonlocality as Evidence for a Multiverse Cosmology

    CERN Document Server

    Tipler, Frank J

    2010-01-01

    I show that observations of quantum nonlocality can be interpreted as purely local phenomena, provided one assumes that the cosmos is a multiverse. Conversely, the observation of quantum nonlocality can be interpreted as observation evidence for a multiverse cosmology, just as observation of the setting of the Sun can be interpreted as evidence for the Earth's rotation.

  10. Evidence-based diagnosis in patch testing

    NARCIS (Netherlands)

    van der Valk, PGM; Devos, SA; Coenraads, PJ

    2003-01-01

    Evidence-based medicine (EBM) is defined as the integration of the best research evidence with clinical expertise and patient values. Based on the principles of EBM, we can conclude that patch testing is cost-effective only if patients are selected on the basis of a clear-cut clinical suspicion of c

  11. Semantic Modelling of Digital Forensic Evidence

    Science.gov (United States)

    Kahvedžić, Damir; Kechadi, Tahar

    The reporting of digital investigation results are traditionally carried out in prose and in a large investigation may require successive communication of findings between different parties. Popular forensic suites aid in the reporting process by storing provenance and positional data but do not automatically encode why the evidence is considered important. In this paper we introduce an evidence management methodology to encode the semantic information of evidence. A structured vocabulary of terms, ontology, is used to model the results in a logical and predefined manner. The descriptions are application independent and automatically organised. The encoded descriptions aim to help the investigation in the task of report writing and evidence communication and can be used in addition to existing evidence management techniques.

  12. Association Between Cannabis and Psychosis: Epidemiologic Evidence.

    Science.gov (United States)

    Gage, Suzanne H; Hickman, Matthew; Zammit, Stanley

    2016-04-01

    Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the findings as causal. We also review the evidence identifying groups at particularly high risk of developing psychosis from using cannabis. Overall, evidence from epidemiologic studies provides strong enough evidence to warrant a public health message that cannabis use can increase the risk of psychotic disorders. However, further studies are required to determine the magnitude of this effect, to determine the effect of different strains of cannabis on risk, and to identify high-risk groups particularly susceptible to the effects of cannabis on psychosis. We also discuss complementary epidemiologic methods that can help address these questions.

  13. Evidence for Mental Health Occupational Therapy

    Directory of Open Access Journals (Sweden)

    Danielle Hitch

    2015-09-01

    Full Text Available This article reports on the evidence for mental health occupational therapy in peer-reviewed journals from 2000 to 2013. Descriptive and inductive methods were used to address this question, with evidence from CINAHL, OTDBase, PSYCInfo, SCOPUS, and Google Scholar® included. Many articles (n = 1,747 were found that met the inclusion and exclusion criteria. A total of 47 different methods were used to develop evidence for mental health occupational therapy, and evidence appeared in 300 separate peer-reviewed journals. It takes on average 7 months for an article to progress from submission to acceptance, and a further 7 months to progress from acceptance to publication. More than 95% of articles published between 2000 and 2002 were cited at least once in the following decade, and around 70% of these citations were recorded in non-occupational therapy journals. The current evidence base for mental health occupational therapy is both substantial and diverse.

  14. Where's the evidence? An innovative approach to teaching staff about evidence-based practice.

    Science.gov (United States)

    Phillips, Janice M; Heitschmidt, Mary; Joyce, Mary Beth; Staneva, Ilianna; Zemansky, Peggy; Francisco, Mary Ann; Powell, Barbara; Kennedy, Terri; Kranzer, Susan French

    2006-01-01

    Preparing nurses to incorporate research and evidence-based findings into nursing practice is important to meet the needs of patients and their families in today's healthcare arena. This article highlights the use of a mock trial as an innovative approach to educating staff nurses on evidence-based practice and identifies future implications for educating staff nurses on incorporating evidence into nursing practice.

  15. Measuring Use of Research Evidence: The Structured Interview for Evidence Use

    Science.gov (United States)

    Palinkas, Lawrence A.; Garcia, Antonio R.; Aarons, Gregory A.; Finno-Velasquez, Megan; Holloway, Ian W.; Mackie, Thomas I.; Leslie, Laurel K.; Chamberlain, Patricia

    2016-01-01

    Objectives: This article describes the Standard Interview for Evidence Use (SIEU), a measure to assess the level of engagement in acquiring, evaluating, and applying research evidence in health and social service settings. Method: Three scales measuring input, process, and output of research evidence and eight subscales were identified using…

  16. 20 CFR 219.23 - Evidence to prove death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence to prove death. 219.23 Section 219... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.23 Evidence to prove death. (a) Preferred evidence of death. The best evidence of a person's death is— (1) A certified copy of or extract from...

  17. The Evidence-Based Manifesto for School Librarians

    Science.gov (United States)

    Todd, Ross

    2008-01-01

    School Library Journal's 2007 Leadership Summit, "Where's the Evidence? Understanding the Impact of School Libraries," focused on the topic of evidence-based practice. Evidence-based school librarianship is a systematic approach that engages research-derived evidence, school librarian-observed evidence, and user-reported evidence in the processes…

  18. Evidence-based dentistry: what's new?

    Science.gov (United States)

    Ballini, A; Capodiferro, S; Toia, M; Cantore, S; Favia, G; De Frenza, G; Grassi, F R

    2007-06-06

    The importance of evidence for every branch of medicine in teaching in order to orient the practitioners among the great amount of most actual scientific information's, and to support clinical decisions, is well established in health care, including dentistry. The practice of evidence-based medicine is a process of lifelong, self-directed, problem-based learning which leads to the need for clinically important information about diagnosis, prognosis, therapy and other clinical and health care issues. Nowadays the practice of dentistry is becoming more complex and challenging because of the continually changing in dental materials and equipments, an increasingly litigious society, an increase in the emphasis of continuing professional development, the information explosion and the consumer movement associated with advances on the Internet. The need for reliable information and the electronic revolution have come together to allow the "paradigm shift" towards evidence-based health care. Recent years have seen an increase in the importance of evidence-based dentistry, aiming to reduce to the maximum the gap between clinical research and real world dental practice. Aim of evidence-based practice is the systematic literature review, which synthesizes the best evidences and provides the basis for clinical practice guidelines. These practice guidelines give a brief review of what evidence-based dentistry is and how to use it.

  19. Evidence-based policymaking: a critique.

    Science.gov (United States)

    Greenhalgh, Trisha; Russell, Jill

    2009-01-01

    The idea that policy should be based on best research evidence might appear to be self-evident. But a closer analysis reveals a number of problems and paradoxes inherent in the concept of "evidence-based policymaking." The current conflict over evidence-based policymaking parallels a long-standing "paradigm war" in social research between positivist, interpretivist, and critical approaches. This article draws from this debate in order to inform the discussions over the appropriateness of evidence- based policymaking and the related question of what is the nature of policymaking. The positivist, empiricist worldview that underpins the theory and practice of evidence-based medicine (EBM) fails to address key elements of the policymaking process. In particular, a narrowly "evidence-based" framing of policymaking is inherently unable to explore the complex, context-dependent, and value-laden way in which competing options are negotiated by individuals and interest groups. Sociolinguistic tools such as argumentation theory offer opportunities for developing richer theories about how policymaking happens. Such tools also have potential practical application in the policymaking process: by enhancing participants' awareness of their own values and those of others, the quality of the collective deliberation that lies at the heart of policymaking may itself improve.

  20. Evidence-Based Dentistry: What's New?

    Directory of Open Access Journals (Sweden)

    A. Ballini, S. Capodiferro, M. Toia, S. Cantore, G. Favia, G. De Frenza, F.R. Grassi

    2007-01-01

    Full Text Available The importance of evidence for every branch of medicine in teaching in order to orient the practitioners among the great amount of most actual scientific information's, and to support clinical decisions, is well established in health care, including dentistry. The practice of evidence-based medicine is a process of lifelong, self-directed, problem-based learning which leads to the need for clinically important information about diagnosis, prognosis, therapy and other clinical and health care issues. Nowadays the practice of dentistry is becoming more complex and challenging because of the continually changing in dental materials and equipments, an increasingly litigious society, an increase in the emphasis of continuing professional development, the information explosion and the consumer movement associated with advances on the Internet. The need for reliable information and the electronic revolution have come together to allow the “paradigm shift” towards evidence-based health care. Recent years have seen an increase in the importance of evidence-based dentistry, aiming to reduce to the maximum the gap between clinical research and real world dental practice. Aim of evidence-based practice is the systematic literature review, which synthesizes the best evidences and provides the basis for clinical practice guidelines. These practice guidelines give a brief review of what evidence-based dentistry is and how to use it.

  1. Weight of Evidence Allocates Mineral Depositional Zones

    Directory of Open Access Journals (Sweden)

    Abdullah A. Bokhari

    2010-01-01

    Full Text Available Problem statement: Yunnan province in general and Pulang area in particular is geological rich area which prevents field study in multi locations due to high risk outcrop. Approach: New technology such as Geographic Information System (GIS and an ArcView extension module Arcweight of evidence (WofE became very handy to provide safety for researchers and allow organization to control their budget. Results: In order to guide mineral exploration, to achieve the purpose of rapid evaluation of mineral resources a serial of modeled prediction methods were established. Weight of evidence model is to predict the existent thing by combining the known evidence of the study area, the importance of evidence is determined based on statistical method. Contrary to the fuzzy logic method, it avoids the subjective selection of evidence and the subjective evaluation of evidence. The weight of evidence can determine the weight in the same standard conditions (using known mine sites as guidance data, so that the variables can be compared in the united scale, a higher reliability. Conclusion/Recommendations: Comparing predicted and known distribution patterns of porphyry, most mine sites are located in the areas with high posterior probability, forecast area accounts for 11.5% of the entire study area. Predicted results show clearly that the boundary of potential areas and the non-potential areas is clear. Therefore, fuzzy logic and other methods should be applied to predict the results for further comparison. More accurate prediction would draw a big smile on faces of share holders.

  2. Evidence for practice, epistemology, and critical reflection.

    Science.gov (United States)

    Avis, Mark; Freshwater, Dawn

    2006-10-01

    Evidence-based practice (EBP) has become a critical concept for ethical, accountable professional nursing practice. However, critical analysis of the concept suggests that EBP overemphasizes the value of scientific evidence while underplaying the role of clinical judgement and individual nursing expertise. This paper explores the empiricist position that valid evidence is the basis for all knowledge claims. We argue against the positivist idea that science should be regarded as the only credible means for generating evidence on which to base knowledge claims. We propose that the process of critically reflecting on evidence is a fundamental feature of empirical epistemology. We suggest that critical reflection on evidence derived from science, arts and humanities and, in particular, nursing practice experience can provide a sound basis for knowledge claims. While we do not attempt to define what counts as evidence, it is argued that there is much to be gained by making the processes of critical reflection explicit, and that it can make a valid contribution to expert nursing practice, without recourse to irreducible concepts such as intuition.

  3. Panspermia: Evidence from Astronomy to Meteorites

    Science.gov (United States)

    Wickramasinghe, N. C.; Wallis, J.; Wallis, D. H.

    The theory of cometary panspermia is reviewed in relation to evidence from astronomy, biology, and recent studies of meteorites. The spectroscopic signatures in interstellar material within our galaxy and in external galaxies that have been known for many years most plausibly represent evidence for the detritus of life existing on a cosmic scale. Such spectral features discovered in galaxies of high redshift points to life arising at a very early stage in the history of the Universe. Evidence of fossils of microscopic life forms in meteorites that have been discussed over several decades, and augmented recently with new data, reaffirms the case for cometary panspermia.

  4. Engineering evidence for carbon monoxide toxicity cases.

    Science.gov (United States)

    Galatsis, Kosmas

    2016-07-01

    Unintentional carbon monoxide poisonings and fatalities lead to many toxicity cases. Given the unusual physical properties of carbon monoxide-in that the gas is odorless and invisible-unorganized and erroneous methods in obtaining engineering evidence as required during the discovery process often occurs. Such evidence gathering spans domains that include building construction, appliance installation, industrial hygiene, mechanical engineering, combustion and physics. In this paper, we attempt to place a systematic framework that is relevant to key aspects in engineering evidence gathering for unintentional carbon monoxide poisoning cases. Such a framework aims to increase awareness of this process and relevant issues to help guide legal counsel and expert witnesses.

  5. Consequences of Assessment: What is the Evidence?

    Directory of Open Access Journals (Sweden)

    William A. Mehrens

    1998-07-01

    Full Text Available Attention is here directed toward the prevalence of large scale assessments (focusing primarily on state assessments. I examine the purposes of these assessment programs; enumerate both potential dangers and benefits of such assessments; investigate what the research evidence says about assessment consequences (including a discussion of the quality of the evidence; discuss how to evaluate whether the consequences are good or bad; present some ideas about what variables may influence the probabilities for good or bad consequences; and present some tentative conclusions about the whole issue of the consequences of assessment and the amount of evidence available and needed.

  6. New weighting factors assignment of evidence theory based on evidence distance

    Institute of Scientific and Technical Information of China (English)

    Chen Liangzhou; Shi Wenkang; Du Feng

    2005-01-01

    Evidence theory has been widely used in the information fusion for its effectiveness of the uncertainty reasoning. However, the classical DS evidence theory involves counter-intuitive behaviors when the high conflict information exists. Based on the analysis of some modified methods, Assigning the weighting factors according to the intrinsic characteristics of the existing evidence sources is proposed, which is determined on the evidence distance theory. From the numerical examples, the proposed method provides a reasonable result with good convergence efficiency. In addition, the new rule retrieves to the Yager's formula when all the evidence sources contradict to each other completely.

  7. Babies' Marijuana Exposure Evident in Their Pee

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_162472.html Babies' Marijuana Exposure Evident in Their Pee Parents should reduce ... 9, 2016 (HealthDay News) -- Babies exposed to secondhand marijuana smoke take in THC, the primary psychoactive chemical ...

  8. Double swab technique for collecting touched evidence.

    Science.gov (United States)

    Pang, B C M; Cheung, B K K

    2007-07-01

    Touched evidence is often submitted to forensic laboratories for DNA analysis. Classical stain recovery technique, involving one wet cotton swab, is commonly used for recovering the touched evidence. Double swab technique, using a wet cotton swab followed by a dry cotton swab, was compared with the classical technique for recovering the touched evidence. The wet cotton swabs and the dry cotton swabs were individually extracted. DNA extracts were quantified and amplified at 15 polymorphic loci. DNA recovered in some of the second dry swabs contained sufficient amount of DNA to yield a DNA profile. This study shows that the double swab technique improves the quality of the resulting DNA profiles. The double swab technique for recovering touched evidence at crime scenes is recommended.

  9. 16 CFR 3.43 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... danger of unfair prejudice, confusion of the issues, or if the evidence would be misleading, or based on... person, in a manner complying with any Act of Congress or rule prescribed by the Supreme Court...

  10. 7 CFR 1.332 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... Under the Program Fraud Civil Remedies Act of 1986 § 1.332 Evidence. (a) The ALJ shall determine the... danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or...

  11. 38 CFR 42.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.34 Evidence. (a) The ALJ shall determine the... unfair prejudice, confusion of the issues, or by considerations of undue delay or needless...

  12. 14 CFR 1264.133 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... PENALTIES ACT OF 1986 § 1264.133 Evidence. (a) The presiding officer shall determine the admissibility of... outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay...

  13. 28 CFR 71.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71.34 Evidence. (a... outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay...

  14. Parkinson's disease: evidence for environmental risk factors.

    Science.gov (United States)

    Kieburtz, Karl; Wunderle, Kathryn B

    2013-01-01

    Parkinson's disease (PD) has no known cause. Although recent research has focused particularly on genetic causes of PD, environmental causes also play a role in developing the disease. This article reviews environmental factors that may increase the risk of PD, as well as the evidence behind those factors. Enough evidence exists to suggest that age has a causal relationship to PD. Significant evidence exists that gender, tobacco use, and caffeine consumption are also associated with the development of PD. Other environmental factors (pesticide exposure, occupation, blood urate levels, NSAID use, brain injury, and exercise) have limited or conflicting evidence of a relationship to PD. Future research must not neglect the impact of these environmental factors on the development of PD, especially with respect to potential gene-environment interactions.

  15. Evidence-based equine dentistry: preventive medicine.

    Science.gov (United States)

    Carmalt, James L

    2007-08-01

    Dental problems are some of the most common reasons for a horse to be presented to an equine veterinarian. Despite the importance of anecdotal evidence as a starting point, the science of equine dentistry (especially prophylactic dentistry) has remained poorly supported by evidence-based approaches to diagnosis and treatment. In the 21st century, veterinarians have an ethical responsibility to promote and use the results of evidence-based research and not propagate statements attesting to the purported benefits of intervention without supporting research. Consider also that society is becoming more litigious and therefore is basing treatment plans and advice on published research, which protects the profession from legal challenges concerning our professional conduct. This article reviews the current published evidence concerning the role of equine dentistry in feed digestibility and performance.

  16. Practice-Based Evidence: Delivering What Works

    Science.gov (United States)

    Brendtro, Larry K.; Mitchell, Martin L.

    2012-01-01

    Many methods claim to be Evidence-Based Practices. Yet success comes not from a particular practice, but principles that underlie all effective helping. This article uses the principle of consilience to tap knowledge from science, values, and practical experience.

  17. 20 CFR 422.107 - Evidence requirements.

    Science.gov (United States)

    2010-04-01

    .... Examples of the types of evidence which may be submitted are a birth certificate, a religious record... applicant's name and (1) the applicant's age, date of birth, or parents' names; and/or (2) a photograph...

  18. Ethics, equality and evidence in health promotion

    DEFF Research Database (Denmark)

    Vallgårda, Signild

    2014-01-01

    Abstract Aim: The Danish National Board of Health has expressed its commitment to social equality in health, evidence-informed health promotion and public health ethics, and has issued guidelines for municipalities on health promotion, in Danish named prevention packages.The aim of this article...... is to analyse whether the Board of Health adheres to ideals of equality, evidence and ethics in these guidelines. Methods: An analysis to detect statements about equity, evidence and ethics in 10 health promotion packages directed at municipalities with the aim of guiding the municipalities towards evidence......-informed disease prevention and health promotion. Results: Despite declared intentions of prioritizing social equality in health, these intentions are largely absent from most of the packages.When health inequalities are mentioned, focus is on the disadvantaged or the marginalized. Several interventions...

  19. More Evidence Linking Obesity to Liver Cancer

    Science.gov (United States)

    ... fullstory_161494.html More Evidence Linking Obesity to Liver Cancer And type 2 diabetes more than doubles the ... type 2 diabetes, may raise your risk for liver cancer, a new study suggests. "We found that each ...

  20. New solar flare evidence may solve mystery

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    An international group of scientists led by the Mullard Space Science Laboratory (MSSL), University College London, has discovered important new evidence that points to the cataclysmic events that trigger a solar flare and the mechanisms that drive its subsequent evolution.

  1. 40 CFR 27.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ..., evidence may be excluded if its probative value is substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation...

  2. 49 CFR 511.43 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... evidence is admissible, but may be excluded if its probative value is substantially outweighed by unfair prejudice or by considerations of undue delay, waste of time, immateriality, or needless presentation of... available for consideration by any reviewing authority....

  3. 20 CFR 498.217 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... value is substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation of cumulative evidence. (d) Although relevant,...

  4. 20 CFR 355.34 - Evidence.

    Science.gov (United States)

    2010-04-01

    ..., evidence may be excluded if its probative value is substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation...

  5. 31 CFR 16.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ..., evidence may be excluded if its probative value is substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless presentation...

  6. 29 CFR 1603.214 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... STATE AND LOCAL GOVERNMENT EMPLOYEE COMPLAINTS OF EMPLOYMENT DISCRIMINATION UNDER SECTION 304 OF THE GOVERNMENT EMPLOYEE RIGHTS ACT OF 1991 Hearings § 1603.214 Evidence. The administrative law judge...

  7. Evidence-Based Dentistry: What's New?

    OpenAIRE

    A. Ballini, S. Capodiferro, M. Toia, S. Cantore, G. Favia, G. De Frenza, F.R. Grassi

    2007-01-01

    The importance of evidence for every branch of medicine in teaching in order to orient the practitioners among the great amount of most actual scientific information's, and to support clinical decisions, is well established in health care, including dentistry. The practice of evidence-based medicine is a process of lifelong, self-directed, problem-based learning which leads to the need for clinically important information about diagnosis, prognosis, therapy and other clinical and health care ...

  8. First evidence of enterobiasis in ancient Egypt.

    Science.gov (United States)

    Horne, P D

    2002-10-01

    The oldest and most common parasite for which we have direct evidence, in the New World, is Enterobius vernicularis. Numerous archaeological sites, especially in the arid American southwest, have yielded fecal samples positive for pinworm ova, some of these dating back 10,000 yr. Reports of pinworm from the Old World are scarce. This article reports the first evidence of pinworm infection from Roman-occupied (30 BC-AD 395) Egypt.

  9. Consequences of Assessment: What is the Evidence?

    OpenAIRE

    William A. Mehrens

    1998-01-01

    Attention is here directed toward the prevalence of large scale assessments (focusing primarily on state assessments). I examine the purposes of these assessment programs; enumerate both potential dangers and benefits of such assessments; investigate what the research evidence says about assessment consequences (including a discussion of the quality of the evidence); discuss how to evaluate whether the consequences are good or bad; present some ideas about what variables may influence the pro...

  10. Wage Dynamics: Reconciling Theory and Evidence

    OpenAIRE

    Olivier Jean Blanchard; Lawrence Katz

    1999-01-01

    U.S. macroeconomic evidence shows a negative relation between the rate of change of wages and unemployment. In contrast, most theories of wage determination imply a negative relation between the level of wages and unemployment. In this paper, we ask whether one can reconcile the empirical evidence with theoretical wage relations. We reach three main conclusions. First, we derive the condition under which the two can indeed be reconciled. We show the constraints that such a condition imposes o...

  11. Introducing AORN's new model for evidence rating.

    Science.gov (United States)

    Spruce, Lisa; Van Wicklin, Sharon A; Hicks, Rodney W; Conner, Ramona; Dunn, Debra

    2014-02-01

    Nurses today are expected to implement evidence-based practices in the perioperative setting to assess and implement practice changes. All evidence-based practice begins with a question, a practice problem to address, or a needed change that is identified. To assess the question, a literature search is performed and relevant literature is identified and appraised. The types of evidence used to inform practice can be scientific research (eg, randomized controlled trials, systematic reviews) or nonresearch evidence (eg, regulatory and accrediting agency requirements, professional association practice standards and guidelines, quality improvement project reports). The AORN recommended practices are a synthesis of related knowledge on a given topic, and the authorship process begins with a systematic review of the literature conducted in collaboration with a medical librarian. At least two appraisers independently evaluate the applicable literature for quality and strength by using the AORN Research Appraisal Tool and AORN Non-Research Appraisal Tool. To collectively appraise the evidence supporting particular practice recommendations, the AORN recommended practices authors have implemented a new evidence rating model that is appropriate for research and nonresearch literature and that is relevant to the perioperative setting.

  12. Plausibility and evidence: the case of homeopathy.

    Science.gov (United States)

    Rutten, Lex; Mathie, Robert T; Fisher, Peter; Goossens, Maria; van Wassenhoven, Michel

    2013-08-01

    Homeopathy is controversial and hotly debated. The conclusions of systematic reviews of randomised controlled trials of homeopathy vary from 'comparable to conventional medicine' to 'no evidence of effects beyond placebo'. It is claimed that homeopathy conflicts with scientific laws and that homoeopaths reject the naturalistic outlook, but no evidence has been cited. We are homeopathic physicians and researchers who do not reject the scientific outlook; we believe that examination of the prior beliefs underlying this enduring stand-off can advance the debate. We show that interpretations of the same set of evidence--for homeopathy and for conventional medicine--can diverge. Prior disbelief in homeopathy is rooted in the perceived implausibility of any conceivable mechanism of action. Using the 'crossword analogy', we demonstrate that plausibility bias impedes assessment of the clinical evidence. Sweeping statements about the scientific impossibility of homeopathy are themselves unscientific: scientific statements must be precise and testable. There is growing evidence that homeopathic preparations can exert biological effects; due consideration of such research would reduce the influence of prior beliefs on the assessment of systematic review evidence.

  13. Medicina embasada em evidências

    Directory of Open Access Journals (Sweden)

    Duncan B.B.

    1999-01-01

    Full Text Available O aumento crescente das opções diagnósticas e terapêuticas cria a necessidade de avaliar sua efetividade, o que pode ser feito, por exemplo, com o ensaio clínico randomizado. A difusão deste e de outros métodos da epidemiologia clínica na prática médica propicia o paradigma da "medicina embasada em evidências". Ao enfatizar a necessidade de evidências clínico-epidemiológicas sólidas para as decisões clínicas, a medicina embasada em evidências forma a estrutura para a integração dos resultados de pesquisas na prática clínica. A evidência é graduada pelo delineamento de pesquisa, fornecendo normas que estabelecem qual o grau adequado para a tomada de decisão médica. A combinação desse novo paradigma com o poder das telecomunicações modernas está causando uma revolução no modo em que a medicina é praticada. O processo é facilitado pelo acesso dos clínicos às revisões quantitativas e aos guidelines (posicionamentos clínicos delas derivados. As limitações das fontes tradicionais de evidências médicas e as vantagens das novas fontes de evidências, como o ACP Journal Club e a Cochrane Collaboration, são descritas. É importante que o médico se familiarize com os conceitos e técnicas do paradigma de medicina embasada em evidências.

  14. Teaching evidence based medicine in family medicine

    Directory of Open Access Journals (Sweden)

    Davorka Vrdoljak

    2012-05-01

    Full Text Available The concept of evidence based medicine (EBM as the integrationof clinical expertise, patient values and the best evidence was introduced by David Sackett in the 1980’s. Scientific literature in medicine is often marked by expansion, acummulation and quick expiration. Reading all important articles to keep in touch with relevant information is impossible. Finding the best evidence that answers a clinical question in general practice (GP in a short time is not easy. Five useful steps are described –represented by the acronym “5A+E”: assess, ask, acquire, appraise, apply and evaluate.The habit of conducting an evidence search “on the spot’’ is proposed. Although students of medicine at University of Split School of Medicine are taught EBM from the first day of their study and in all courses, their experience of evidence-searching and critical appraisal of the evidence, in real time with real patient is inadequate. Teaching the final-year students the practical use of EBM in a GP’s office is different and can have an important role in their professional development. It can positively impact on quality of their future work in family practice (or some other medical specialty by acquiring this habit of constant evidence-checking to ensure that best practice becomes a mechanism for life-long learning. Conclusion. EBM is a foundation stone of every branch of medicine and important part of Family Medicine as scientific and professional discipline. To have an EB answer resulting from GP’s everyday work is becoming a part of everyday practice.

  15. THE EXCLUSION OF ILEGALLY ADMINISTERED EVIDENCE

    Directory of Open Access Journals (Sweden)

    Eliza Emanuela IONIŢĂ

    2015-07-01

    Full Text Available Both judicial practice and specialized texts have brought up the problem of what the punishment for breaking the legal provisions in the activity of evidence administration is, if a matter of fact had been presented by means that are not legally specified or if a piece of evidence was administered by means that are legally specified, but with the violation of legal provisions. Romania has adhered to the most important international juridical instruments adopted in the sphere of human rights by the adoption, modification or completion of internal legislation. As such, for the first time in Romanian criminal procedural legislation, a sanction for the exclusion of evidence has been introduced, as a corollary for the principle of legality and of loyalty in administering evidence. The New Criminal Procedure Code provides the sanction of exclusion as well, but this time the legislator didn’t resume his or herself to a mere conceptual regulation of the sanction, providing both a specific invalidation procedure as well as procedural solutions. In the New Criminal Procedure Code it is shown that in the sphere of evidence-showing a set of rules has been introduced that establishes the principle of loyalty in the obtainment of evidence. These rules, that provide the sanction of excluding evidence obtained through illegal or unloyal means, will determined the growth of professionalism in the ranks of the judiciary bodies on the subject of obtaining evidence and, on the other hand, will guarantee the firm upholding of the parties rights to a fair trial. “Truth, like all other good things, may be loved unwisely – may be pursued too keenly – may cost too much…” Lord Justice Sir James Lewis Knight-Bruce ”It is a deeply ingrained value in our democratic system that the ends do not justify the means. In particular, evidence or convictions may, at times, be obtained at too high a price”. – Antonio Lamer Former Chief Justice of the Supreme Court

  16. 20 CFR 404.728 - Evidence a marriage has ended.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Evidence a marriage has ended. 404.728... DISABILITY INSURANCE (1950- ) Evidence Evidence of Age, Marriage, and Death § 404.728 Evidence a marriage has ended. (a) When evidence is needed that a marriage has ended. If you apply for benefits as the...

  17. 20 CFR 219.24 - Evidence of presumed death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of presumed death. 219.24 Section... EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but evidence of death is needed, the Board may presume he or she died at a...

  18. 20 CFR 404.720 - Evidence of a person's death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Evidence of a person's death. 404.720 Section... INSURANCE (1950- ) Evidence Evidence of Age, Marriage, and Death § 404.720 Evidence of a person's death. (a) When evidence of death is required. If you apply for benefits on the record of a deceased person,...

  19. Evidence, temperature, and the laws of thermodynamics.

    Science.gov (United States)

    Vieland, Veronica J

    2014-01-01

    A primary purpose of statistical analysis in genetics is the measurement of the strength of evidence for or against hypotheses. As with any type of measurement, a properly calibrated measurement scale is necessary if we want to be able to meaningfully compare degrees of evidence across genetic data sets, across different types of genetic studies and/or across distinct experimental modalities. In previous papers in this journal and elsewhere, my colleagues and I have argued that geneticists ought to care about the scale on which statistical evidence is measured, and we have proposed the Kelvin temperature scale as a template for a context-independent measurement scale for statistical evidence. Moreover, we have claimed that, mathematically speaking, evidence and temperature may be one and the same thing. On first blush, this might seem absurd. Temperature is a property of systems following certain laws of nature (in particular, the 1st and 2nd Law of Thermodynamics) involving very physical quantities (e.g., energy) and processes (e.g., mechanical work). But what do the laws of thermodynamics have to do with statistical systems? Here I address that question.

  20. Forensic Evidence in Homicide Investigations and Prosecutions.

    Science.gov (United States)

    McEwen, Tom; Regoeczi, Wendy

    2015-09-01

    Even though forensic evidence is collected at virtually every homicide scene, only a few studies have examined its role in investigation and prosecution. This article adds to the literature by providing the results of a study of 294 homicide cases (315 victims) occurring in Cleveland, Ohio, between 2008 and 2011. Through a logistic regression on open versus closed cases, the collection of knives, administration of gunshot residue (GSR) kits, and clothing at the scene were positively and significantly related to case closures, while collection of ballistics evidence and DNA evidence were statistically significant in the opposite direction. With regard to analysis, the clearance rate for cases with probative results (i.e., matches or exclusions) was 63.1% compared to a closure rate of 56.3% for cases without probative results. However, only 23 cases had probative results prior to arrest compared to 128 cases with probative results after arrest.

  1. The fallacy of evidence based policy

    CERN Document Server

    Saltelli, Andrea

    2016-01-01

    The use of science for policy is at the core of a perfect storm generated by the insurgence of several concurrent crises: of science, of trust, of sustainability. The modern positivistic model of science for policy, known as evidence based policy, is based on dramatic simplifications and compressions of available perceptions of the state of affairs and possible explanations (hypocognition). This model can result in flawed prescriptions. The flaws become more evident when dealing with complex issues characterized by concomitant uncertainties in the normative, descriptive and ethical domains. In this situation evidence-based policy may concur to the fragility of the social system. Science plays an important role in reducing the feeling of vulnerability of humans by projecting a promise of protection against uncertainties. In many applications quantitative science is used to remove uncertainty by transforming it into probability, so that mathematical modelling can play the ritual role of haruspices. This epistem...

  2. Book Review: Challenges to Digital Forensic Evidence

    Directory of Open Access Journals (Sweden)

    Gary Kessler

    2008-03-01

    Full Text Available Cohen, F. (2008. Challenges to Digital Forensic Evidence. Livermore, CA: Fred Cohen & Associates. 129 pages, ISBN: 1-878109-41-3, US$39.Reviewed by Gary C. Kessler (gary.kessler@champlain.eduThis book is about evidence gleaned as the result of the digital forensics process and providing expert testimony about that evidence. I am always suspicious when someone self-proclaims themselves as an "expert" although all authors are doing just that, at least by inference. Readers who are familiar with the author, Fred Cohen, or his large body of published works will know that he neither proclaims his expertise quietly nor inaccurately. Indeed, Cohen is an ideal person to weigh in on the topic of suitability and malleability of information acquired from computers and about providing testimony about that information and the process with which it was found.(see PDF for full review

  3. Evidence based practice of chronic pain

    Directory of Open Access Journals (Sweden)

    Rakesh Garg

    2012-01-01

    Full Text Available The patients with chronic pain are increasingly reporting to the physicians for its management. Chronic pain are associated with head, neck and shoulder pain, spinal pain, pain in the joints and extremities, complex regional pain syndrome and phantom pain. The chronic pain is being managed worldwide. The different specialty of medicine is producing a lot of evidence through the published literature but the same is not being published in the field of chronic pain management. Though some evidence is being reported as to different aspects of pain management from different parts of the world but same is lacking from Indian subcontinent. This is in contrast to much done clinical work in this field as well. We present here the available evidence in relation to chronic pain management.

  4. Evidence-based policymaking: A review

    Directory of Open Access Journals (Sweden)

    Karen Nortje

    2010-05-01

    Full Text Available The process of facilitating the uptake of evidence, for example, scientific research findings, into the policymaking process is multifaceted and thus complex. It is therefore important for scientists to understand this process in order to influence it more effectively. Similarly, policymakers need to understand the complexities of the scientific process to improve their interaction with the scientific sphere. This literature review addresses those factors that influence the uptake of scientific evidence into policymaking, the barriers to using science in policymaking, as well as recommendations for improved science–policymaking interaction. A visual diagram of the gears of a car is used to convey the message of the complexities around the engagement between science and policymaking. It is concluded that the issue of evidence-based policymaking remains unresolved and questions for future research on the science–policy interface are raised.

  5. A Corpus for Evidence Based Medicine Summarisation

    Directory of Open Access Journals (Sweden)

    Diego Mollá Aliod

    2012-09-01

    Full Text Available Background Automated text summarisers that find the best clinical evidence reported in collections of medical literature are of potential benefit for the practice of Evidence Based Medicine (EBM. Research and development of text summarisers for EBM, however, is impeded by the lack of corpora to train and test such systems. Aims To produce a corpus for research in EBM summarisation. Method We sourced the “Clinical Inquiries” section of the Journal of Family Practice (JFP and obtained a sizeable sample of questions and evidence based summaries. We further processed the summaries by combining automated techniques, human annotations, and crowdsourcing techniques to identify the PubMed IDs of the references. Results The corpus has 456 questions, 1,396 answer components, 3,036 answer justifications, and 2,908 references. Conclusion The corpus is now available for the research community at http://sourceforge.net/projects/ebmsumcorpus.

  6. Legislating for health: locating the evidence.

    Science.gov (United States)

    Pawson, Ray; Owen, Lesley; Wong, Geoff

    2010-07-01

    This article examines the timorous courtship between public health law and evidence-based policy. Legislation, in the form of direct prescriptions or proscriptions on behaviour, is perhaps the most powerful tool available to the public health policymaker. Increasingly, the same policymakers have striven to ensure that interventions are based soundly on a secure evidence base. The modern mantra is that the policies to follow are the ones that have been demonstrated to work. Legislative interventions, involving trade-offs between public benefit and private interests, present formidable challenges for the evaluator. Systematic reviews of their overall efficacy, the main tool of evidence-based policy, are in their infancy. The article presents a design for such reviews using the example of a forthcoming synthesis on the effectiveness of banning smoking in cars carrying children.

  7. The religion of evidence-based practice

    DEFF Research Database (Denmark)

    Wigram, Tony; Gold, Christian

    2012-01-01

    , and discusses autism spectrum disorders and EBP. The chapter concludes that, based on last sixty years of the development of music therapy as a recognized and relevant intervention, there is no doubt that the honeymoon period is over, and EBP is here to stay. Despite examples of attrition in music therapy......This chapter begins by outlining the challenges of preparing a chapter on evidence-based practice (EBP) to underpin the use of music as a therapeutic tool in treatment, in the overall frame of music, health, and wellbeing. It then reviews the terminology of EBP and evidence-based medicine...... practice as health, education, and social services tighten their belts and the demand on their resources grows, there is increasing interest in the value of music for health and wellbeing, despite even less ‘hard’ evidence that it is effective against illness and disability....

  8. Evidence-based Management of Glaucoma

    Institute of Scientific and Technical Information of China (English)

    Yangfan Yang; Minbin Yu

    2005-01-01

    Purpose: The evidence-based medicine (EBM) is a new medical mode that is completely different from traditional experience-based medicine. The core of EBM is that decision-making during clinical practices must be based on objective research results.With the rapid development of modern ophthalmology, some former viewpoints according to experience-based medicine face challenges. Evidence-based ophthalmology (EBO) is imperative under the situation. Glaucoma, as a disease resulting in blindness, which can not be cured by operation, is thought more and more of by medical management officials and doctors. One challenge for ophthalmologists entering the 21st century will be to make clinical decisions based on valid information or evidence rather than intuition, hearsay, or peer practice. How can we do? Here reviews the application of EBM in medical management of glaucoma since EBM' s naissance and give a reference.

  9. Study Questions Reliability of Fingerprint Evidence

    Institute of Scientific and Technical Information of China (English)

    James; Randerson; 陈易

    2007-01-01

    The reliability of fingerprint has been called into question by a study that tested whether forensic experts make consistent judgments on print matches.Despite the perceived infallibility of fingerprint evidence, the study found that experts do not always make the same judgment on whether a print matches a mark at a crime scene when presented with the same evidence twice.The findings come in the wake of two high profile cases in which fingerprint matches were subsequently shown to be wrong. The Scottish ...

  10. Professionalism and evidence-based practice

    DEFF Research Database (Denmark)

    Rasmussen, Palle

    2015-01-01

    The idea of evidence- based practice is influential in public welfare services, including education. The idea is controversial, however, not least because it involves a poten tial redefinition of the relation ship between knowledge, authority and professionalism. This is discussed based on a study...... of evidence- based methods in Danish pre-school education and care. The management sees the use of these methods as strengthening pre- school teacher professionalism, but the actual practices in the day-careinstitutions are ambiguous. In some cases, using the methods becomes an end in itself and tends...

  11. Evidence Based Practice: Science? Or Art? (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2011-03-01

    Full Text Available Evidence based library and information practice (EBLIP is a strategy to bridge research and practice. Generally EBLIP is seen as a movement to encourage and give practitioners the means to incorporate research into their practice, where it previously may have been lacking. The widely accepted definition of EBLIP (Booth, 2000 stresses three aspects that contribute to a practice that is evidence based: 1 "the best available evidence;" 2 "moderated by user needs and preferences;" 3 "applied to improve the quality of professional judgements." The area that the EBLIP movement has focused on is how to create and understand the best available research evidence. CE courses, critical appraisal checklists, and many articles have been written to address a need for librarian education in this area, and it seems that strides have been made.But very little in the EBLIP literature talks about how we make professional judgements, or moderate evidence based on our user needs and preferences. Likewise, how do we make good evidence based decisions when our evidence base is weak. These things seem to be elements we just take for granted or can’t translate into words. It is in keeping with tacit knowledge that librarians just seem to have or acquire skills with education and on the job experience. Tacit knowledge is "knowledge that is not easily articulated, and frequently involves knowledge of how to do things. We can infer its existence only by observing behaviour and determining that this sort of knowledge is a precondition for effective performance" (Patel, Arocha, & Kaufman, 1999, p.78. It is something that is difficult to translate into an article or guideline for how we work. I think of this area as the "art" of evidence based practice. And the art is crucial to being an evidence based practitioner.Science = systematized knowledge, explicit research, methodological examination, investigation, dataArt = professional knowledge of your craft, intuition

  12. Best evidence: nasogastric tube placement verification.

    Science.gov (United States)

    Longo, M Anne

    2011-08-01

    Further research on cost-effective techniques to verify enteral tube placement is warranted using a variety of pediatric populations with differing conditions that may impact gastric pH. It is imperative that clinical facilities review current policies and procedures to ensure that evidence-based findings are guiding nursing practice. Many nurses continue to rely on auscultation to verify NGT placement. Education and competency validation can assist with current practices for NGT placement being consistently incorporated by all personnel in the health care setting. Continuing to search for evidence related to nursing care will guide the direct care RN in providing best practice.

  13. Crime prevention: more evidence-based analysis.

    Science.gov (United States)

    Garrido Genovés, Vicente; Farrington, David P; Welsh, Brandon C

    2008-02-01

    This paper introduces a new section of Psicothema dedicated to the evidence-based approach to crime prevention. Along with an original sexual-offender-treatment programme implemented in Spain, this section presents four systematic reviews of important subjects in the criminological arena, such as sexual offender treatment, the well-known programme, the effectiveness of custodial versus non-custodial sanctions in reoffending and the fight against terrorism. We also highlight some of the focal points that scientists, practitioners and governments should take into account in order to support this evidence-based viewpoint of crime prevention.

  14. Evidence for collisionless magnetic reconnection at Mars

    Science.gov (United States)

    Eastwood, J. P.; Brain, D. A.; Halekas, J. S.; Drake, J. F.; Phan, T. D.; Øieroset, M.; Mitchell, D. L.; Lin, R. P.; Acuña, M.

    2008-01-01

    Using data from Mars Global Surveyor (MGS) in combination with Particle-In-Cell (PIC) simulations of reconnection, we present the first direct evidence of collisionless magnetic reconnection at Mars. The evidence indicates that the spacecraft passed through the diffusion region where reconnection is initiated and observed the magnetic field signatures of differential electron and ion motion - the Hall magnetic field - that uniquely indicate the reconnection process. These are the first such in-situ reconnection observations at an astronomical body other than the Earth. Reconnection may be the source of Mars' recently discovered auroral activity and the changing boundaries of the closed regions of crustal magnetic field.

  15. Observation, Sherlock Holmes, and Evidence Based Medicine.

    Science.gov (United States)

    Osborn, John

    2002-01-01

    Sir Arthur Conan Doyle, the creator of the fictional detective Sherlock Holmes, studied medicine at the University of Edinburgh between 1876 and 1881 under Doctor Joseph Bell who emphasised in his teaching the importance of observation, deduction and evidence. Sherlock Holmes was modelled on Joseph Bell. The modern notions of Evidence Based Medicine (EBM) are not new. A very brief indication of some of the history of EBM is presented including a discussion of the important and usually overlooked contribution of statisticians to the Popperian philosophy of EBM.

  16. Towards Trustable Digital Evidence with PKIDEV: PKI Based Digital Evidence Verification Model

    Science.gov (United States)

    Uzunay, Yusuf; Incebacak, Davut; Bicakci, Kemal

    How to Capture and Preserve Digital Evidence Securely? For the investigation and prosecution of criminal activities that involve computers, digital evidence collected in the crime scene has a vital importance. On one side, it is a very challenging task for forensics professionals to collect them without any loss or damage. On the other, there is the second problem of providing the integrity and authenticity in order to achieve legal acceptance in a court of law. By conceiving digital evidence simply as one instance of digital data, it is evident that modern cryptography offers elegant solutions for this second problem. However, to our knowledge, there is not any previous work proposing a systematic model having a holistic view to address all the related security problems in this particular case of digital evidence verification. In this paper, we present PKIDEV (Public Key Infrastructure based Digital Evidence Verification model) as an integrated solution to provide security for the process of capturing and preserving digital evidence. PKIDEV employs, inter alia, cryptographic techniques like digital signatures and secure time-stamping as well as latest technologies such as GPS and EDGE. In our study, we also identify the problems public-key cryptography brings when it is applied to the verification of digital evidence.

  17. Variation, Certainty, Evidence, and Change in Dental Education: Employing Evidence-based Dentistry in Dental Education.

    Science.gov (United States)

    Marinho, Valeria Coelho Catao; Richards, Derek; Niederman, Richard

    2001-01-01

    Using a case-based dental scenario, presents systematic evidence-based methods for accessing dental health care information, evaluating this information for validity and importance, and using this information to make informed curricular and clinical decisions. Also discusses barriers inhibiting these systematic approaches to evidence-based…

  18. How evidence-based are the recommendations in evidence-based guidelines?

    Directory of Open Access Journals (Sweden)

    Finlay A McAlister

    2007-08-01

    Full Text Available BACKGROUND: Treatment recommendations for the same condition from different guideline bodies often disagree, even when the same randomized controlled trial (RCT evidence is cited. Guideline appraisal tools focus on methodology and quality of reporting, but not on the nature of the supporting evidence. This study was done to evaluate the quality of the evidence (based on consideration of its internal validity, clinical relevance, and applicability underlying therapy recommendations in evidence-based clinical practice guidelines. METHODS AND FINDINGS: A cross-sectional analysis of cardiovascular risk management recommendations was performed for three different conditions (diabetes mellitus, dyslipidemia, and hypertension from three pan-national guideline panels (from the United States, Canada, and Europe. Of the 338 treatment recommendations in these nine guidelines, 231 (68% cited RCT evidence but only 105 (45% of these RCT-based recommendations were based on high-quality evidence. RCT-based evidence was downgraded most often because of reservations about the applicability of the RCT to the populations specified in the guideline recommendation (64/126 cases, 51% or because the RCT reported surrogate outcomes (59/126 cases, 47%. CONCLUSIONS: The results of internally valid RCTs may not be applicable to the populations, interventions, or outcomes specified in a guideline recommendation and therefore should not always be assumed to provide high-quality evidence for therapy recommendations.

  19. Employing Evidence Evidence: Does it Have a Job in Vocational Libraries?

    Directory of Open Access Journals (Sweden)

    Brad Jones

    2006-03-01

    Full Text Available Objective - Evidence-based librarianship (EBL springs ffrom medical and academic origins. As librarians are tertiary educated (only occasionally with supplementary qualifications covering research and statistics EBL has an academic focus. The EBL literature has significant content from school and university perspectives, but has had little, if any, vocational content. This paper suggests a possible Evidence Based Librarianship context for vocational libraries. Methods - A multidisciplinary scan of evidence based literature was undertaken, covering medicine and allied health, librarianship, law, science and education. National and international vocational education developments were examined. The concept and use of evidence in vocational libraries was considered. Results - Library practice can generally benefit from generic empirical science methodologies used elsewhere. Different areas, however, may have different concepts of what constitutes evidence and appropriate methodologies. Libraries also need to reflect the evidence used in their host organisations. The Australian vocational librarian has been functioning in an evidence based educational sector: national, transportable, prescriptive, competancy based and outcomes drived Training Packages. These require a qualitatively different concept of evidence compared to the other educational sectors as they reflect pragmatic, economic, employability outcomes. Conclusions - Vocational and other librarians have been doing research but need to be more systematic about design and analysis. Librarians need to develop 'evidence literacy' as one of their professional evaluation skills. Libraries will need to utilise evidence relevant to their host organisations to esablish and maintain credibility, and in the vocational sector this is set in a competency based framework. Competancy based measures are becoming increasingly relevant in school and university(including medical education.

  20. DISCOVERY OF EVIDENCE IN INTERNATIONAL COMMERCIAL ARBITRATION

    Directory of Open Access Journals (Sweden)

    Bakumenko, V.V.

    2016-07-01

    Full Text Available The article considers the different concepts of discovery of evidence, which exist under different legal jurisdictions, with their theoretical analysis to determine the feasibility and rationality of the application of the discovery mechanisms in the frameworks of international commercial arbitration and its fundamental principles.

  1. Justifying Physical Education Based on Neuroscience Evidence

    Science.gov (United States)

    Berg, Kris

    2010-01-01

    Research has shown that exercise improves cognitive function and psychological traits that influence behavior (e.g., mood, level of motivation). The evidence in the literature also shows that physical education may enhance learning or that academic performance is at least maintained despite a reduction in classroom time in order to increase time…

  2. GARCH Option Valuation: Theory and Evidence

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Jacobs, Kris; Ornthanalai, Chayawat

    We survey the theory and empirical evidence on GARCH option valuation models. Our treatment includes the range of functional forms available for the volatility dynamic, multifactor models, nonnormal shock distributions as well as style of pricing kernels typically used. Various strategies...

  3. Quantitative Evidence Synthesis with Power Priors

    NARCIS (Netherlands)

    Rietbergen, C.

    2016-01-01

    The aim of this thesis is to provide the applied researcher with a practical approach for quantitative evidence synthesis using the conditional power prior that allows for subjective input and thereby provides an alternative tgbgo deal with the difficulties as- sociated with the joint power prior di

  4. Evidence-Based Chinese Medicine for Hypertension

    Directory of Open Access Journals (Sweden)

    Jie Wang

    2013-01-01

    Full Text Available Hypertension is an important worldwide public -health challenge with high mortality and disability. Due to the limitations and concerns with current available hypertension treatments, many hypertensive patients, especially in Asia, have turned to Chinese medicine (CM. Although hypertension is not a CM term, physicians who practice CM in China attempt to treat the disease using CM principles. A variety of approaches for treating hypertension have been taken in CM. For seeking the best evidence of CM in making decisions for hypertensive patients, a number of clinical studies have been conducted in China, which has paved the evidence-based way. After literature searching and analyzing, it appeared that CM was effective for hypertension in clinical use, such as Chinese herbal medicine, acupuncture, moxibustion, cupping, qigong, and Tai Chi. However, due to the poor quality of primary studies, clinical evidence is still weak. The potential benefits and safety of CM for hypertension still need to be confirmed in the future with well-designed RCTs of more persuasive primary endpoints and high-quality SRs. Evidence-based Chinese medicine for hypertension still has a long way to go.

  5. Environment and Happiness: New Evidence for Spain

    Science.gov (United States)

    Cunado, Juncal; Perez de Gracia, Fernando

    2013-01-01

    This paper explores the relationship between air pollution, climate and reported subjective well-being (or happiness) in Spanish regions. The results show that, after controlling for most of the socio-economic variables affecting happiness, there are still significant regional differences in subjective well-being. Evidence also suggests that…

  6. Learning From Others About Research Evidence (editorial

    Directory of Open Access Journals (Sweden)

    Alison Brettle

    2012-06-01

    Full Text Available Welcome to the June issue of EBLIP, our firstto be published with an HTML version as wellas PDFs for each article. I hope you enjoy andfind the alternative formats useful. As usualthe issue comprises an interesting range ofevidence summaries and articles that I hopeyou will find useful in applying evidence toyour practice.When considering evidence, two recent trips toEdinburgh got me thinking about the widerange of study designs or methods that areuseful for generating evidence, and also howwe can learn about their use from otherprofessions.The first trip was as part of the cadre of the LISDREaM project (http://lisresearch.org/dreamproject/.DREaM has been set up by the LISResearch Coalition to develop a sustainableLIS research network in the UK. As part ofthis, a series of workshops aims to introduceLIS practitioners to a wider range of researchmethods, thus expanding the methods used inLIS research. Indeed, a quick scan of thecontents of this issue show a preponderance ofsurveys, interviews, and citation analysis,suggesting that broadening our knowledge ofmethods may well be a useful idea. Theworkshops are highly interactive and, at eachsession experts from outside the LIS disciplineintroduce particular research methods andoutline how they could be used in LISapplications. As a result, I can see the valueand understand when to use research methodssuch as social network analysis, horizonscanning, ethnography, discourse analysis, andrepertory grids – as well as knowing that datamining is something I’m likely to avoid! So farI’ve shared my new knowledge with a PhDstudent who was considering her methodologyand incorporated my new knowledge ofhorizon scanning into a bid for researchfunding. The next (and more exciting step isto think of a situation where I can apply one ofthese methods to examining an aspect of LIS practice.The second trip was the British Association ofCounselling and Psychotherapy ResearchConference, an event which I

  7. Time for evidence-based cytology

    Directory of Open Access Journals (Sweden)

    Dey Pranab

    2007-01-01

    Full Text Available Abstract Evidence-based medicine (EBM is a fashionable and an extremely hot topic for clinicians, patients and the health service planners. Evidence-based cytology (EBC is an offshoot of EBM. The EBC is concerned with generating a reproducible, high quality and clinically relevant test result in the field of cytology. This is a rapidly evolving area with high practical importance. EBC is based entirely on research data. The various professional bodies on cytology design and recommend guidelines on the basis of evidences. Once the guideline is implemented and practiced then the experiences of the practicing cytopathologists may be used as a feed back to alter the existing guideline. The various facets of EBC are sampling and specimen adequacy, morphological identification and computer based expert system, integrated reporting, identification of the controversial areas and high quality researches for evidences. It is the duty of the individuals and institutions to practice EBC for better diagnosis and management of the patients. In this present paper, the various aspects of EBC have been discussed.

  8. New Evidence on Teacher Labor Supply

    Science.gov (United States)

    Engel, Mimi; Jacob, Brian A.; Curran, F. Chris

    2014-01-01

    Recent evidence on the large variance in teacher effectiveness has spurred interest in teacher labor markets. Research documents that better qualified teachers typically work in more advantaged schools but cannot determine the relative importance of supply versus demand. To isolate teacher preferences, we document which schools prospective…

  9. 22 CFR 224.34 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Evidence. 224.34 Section 224.34 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224... probative value is substantially outweighed by the danger of unfair prejudice, confusion of the issues,...

  10. 42 CFR 1005.17 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... danger of unfair prejudice, confusion of the issues, or by considerations of undue delay or needless..., wrongs or acts other than those at issue in the instant case is admissible in order to show motive... evidence is admissible regardless of whether the crimes, wrongs or acts occurred during the statute...

  11. 22 CFR 521.34 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Evidence. 521.34 Section 521.34 Foreign Relations BROADCASTING BOARD OF GOVERNORS IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 521.34... substantially outweighed by the danger of unfair prejudice, confusion of the issues, or by consideration...

  12. 8 CFR 1244.9 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... that he or she feels would be helpful in showing nationality. Acceptable evidence in descending order... identification; and/or (iii) Any national identity document from the alien's country of origin bearing photo and... knows the applicant; and (G) Establishes the origin of the information being attested to....

  13. 8 CFR 244.9 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... nationality. During this interview, the applicant may present any secondary evidence that he or she feels... national identity document from the alien's country of origin bearing photo and/or fingerprint. (2) Proof...; and (G) Establishes the origin of the information being attested to. (vi) Additional documents...

  14. African American Homeschooling Practices: Empirical Evidence

    Science.gov (United States)

    Mazama, Ama

    2016-01-01

    Despite a significant increase in scholarly interest for homeschooling, some of its most critical aspects, such as instructional daily practices, remain grossly understudied. This essay thus seeks to fill that void by presenting empirical evidence regarding the homeschooling practices of a specific group, African Americans. Most specifically, the…

  15. Evidence and research in rectal cancer.

    NARCIS (Netherlands)

    Valentini, V.; Beets-Tan, R.; Borras, J.M.; Krivokapic, Z.; Leer, J.W.H.; Pahlman, L.; Rodel, C.; Schmoll, H.J.; Scott, N.; Velde, C.V.; Verfaillie, C.

    2008-01-01

    The main evidences of epidemiology, diagnostic imaging, pathology, surgery, radiotherapy, chemotherapy and follow-up are reviewed to optimize the routine treatment of rectal cancer according to a multidisciplinary approach. This paper reports on the knowledge shared between different specialists inv

  16. Cycads: Fossil evidence of late paleozoic origin

    Science.gov (United States)

    Mamay, S.H.

    1969-01-01

    Plant fossils from Lower Permian strata of the southwestern United States have been interpreted as cycadalean megasporophylls. They are evidently descended from spermopterid elements of the Pennsylvanian Taeniopteris complex; thus the known fossil history of the cycads is extended from the Late Triassic into the late Paleozoic. Possible implications of the Permian fossils toward evolution of the angiosperm carpel are considered.

  17. Behavioural activation: history, evidence and promise.

    Science.gov (United States)

    Kanter, Jonathan W; Puspitasari, Ajeng J; Santos, Maria M; Nagy, Gabriela A

    2012-05-01

    Behavioural activation holds promise to reduce the global burden of depression as a treatment approach that is effective, easy to teach, scalable and acceptable to providers and patients across settings and cultures. This editorial reviews the history of behavioural activation, what it is, current evidence for its use and future directions.

  18. Evidence-Based Classroom Behaviour Management Strategies

    Science.gov (United States)

    Parsonson, Barry S.

    2012-01-01

    This paper reviews a range of evidence-based strategies for application by teachers to reduce disruptive and challenging behaviours in their classrooms. These include a number of antecedent strategies intended to help minimise the emergence of problematic behaviours and a range of those which provide positive consequences for appropriate student…

  19. 20 CFR 901.45 - Evidence.

    Science.gov (United States)

    2010-04-01

    ...' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL... actuaries. However, the Administrative Law Judge shall exclude evidence which is irrelevant, immaterial, or... of Actuaries or the Office of the Executive Director of the Joint Board for the Enrollment...

  20. Patient autonomy in evidence-based dentistry.

    Science.gov (United States)

    Ritwik, Priyanshi

    2014-01-01

    Evidence-based dentistry is the judicious integration of scientific information relating to the patient's oral health and medical condition with the dentist's clinical expertise and the patient's own treatment needs and preferences. In this triad of factors, we (the dentists) are least likely to be formally trained in recognizing our patient's preferences. Do we understand what shapes these preferences?

  1. Unpacking the Evidence of Gender Bias

    Science.gov (United States)

    Fulmer, Connie L.

    2010-01-01

    The purpose of this study was to investigate gender bias in pre-service principals using the Gender-Leader Implicit Association Test. Analyses of student-learning narratives revealed how students made sense of gender bias (biased or not-biased) and how each reacted to evidence (surprised or not-surprised). Two implications were: (1) the need for…

  2. 41 CFR 105-70.034 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Evidence. 105-70.034 Section 105-70.034 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration...

  3. Comment on "Evidence for mesothermy in dinosaurs".

    Science.gov (United States)

    Myhrvold, Nathan P

    2015-05-29

    Grady et al. (Reports, 13 June 2014, p. 1268) studied dinosaur metabolism by comparison of maximum somatic growth rate allometry with groups of known metabolism. They concluded that dinosaurs exhibited mesothermy, a metabolic rate intermediate between endothermy and ectothermy. Multiple statistical and methodological issues call into question the evidence for dinosaur mesothermy.

  4. Evidence-based recommendation on toothpaste use

    Directory of Open Access Journals (Sweden)

    Jaime Aparecido Cury

    2014-01-01

    Full Text Available Toothpaste can be used as a vehicle for substances to improve the oral health of individuals and populations. Therefore, it should be recommended based on the best scientific evidence available, and not on the opinion of authorities or specialists. Fluoride is the most important therapeutic substance used in toothpastes, adding to the effect of mechanical toothbrushing on dental caries control. The use of fluoride toothpaste to reduce caries in children and adults is strongly based on evidence, and is dependent on the concentration (minimum of 1000 ppm F and frequency of fluoride toothpaste use (2'/day or higher. The risk of dental fluorosis due to toothpaste ingestion by children has been overestimated, since there is no evidence that: 1 fluoride toothpaste use should be postponed until the age of 3-4 or older, 2 low-fluoride toothpaste avoids fluorosis and 3 fluorosis has a detrimental effect on the quality of life of individuals exposed to fluoridated water and toothpaste. Among other therapeutic substances used in toothpastes, there is evidence that triclosan/copolymer reduce dental biofilm, gingivitis, periodontitis, calculus and halitosis, and that toothpastes containing stannous fluoride reduce biofilm and gingivitis.

  5. Consequences of Assessment: What Is the Evidence?

    Science.gov (United States)

    Mehrens, William A.

    1998-01-01

    Examines the purposes of large-scale assessment programs, outlines the dangers and benefits of these assessments, considers the research evidence about the consequences of assessment, discusses how to evaluate assessment quality, and presents some ideas about the variables that influence the probabilities for good and bad assessment. (SLD)

  6. Managing Records as Evidence and Information.

    Science.gov (United States)

    Cox, Richard J.

    For the past three decades, policies regarding a variety of information issues have emanated from federal agencies, legislative chambers, and corporate boardrooms. Records policies are critically important for records professionals to develop and use as a means of strategically managing the information and evidence found in the millions of records…

  7. Computational Evidence for the Smallest Boron Nanotube

    Institute of Scientific and Technical Information of China (English)

    Xian Jie LIN; Dong Ju ZHANG; Cheng Bu LIU

    2006-01-01

    The structure of boron nanotubes (BNTs) was found not to be limited to hexagonal pyramidal structures. Based on density functional theory calculations we provided evidence for the smallest boron nanotube, a geometrical analog of the corresponding carbon nanotube. As shown by our calculations, the smallest BNT possesses highly structural, dynamical, and thermal stability, which should be interest for attempts at its synthesis.

  8. Evidence for production of single top quarks

    NARCIS (Netherlands)

    Abazov, V.M.; et al., [Unknown; de Jong, S.J.; Demarteau, M.; Houben, P.; van den Berg, P.J.

    2008-01-01

    We present first evidence for the production of single top quarks in the D0 detector at the Fermilab Tevatron p (p) over bar collider. The standard model predicts that the electroweak interaction can produce a top quark together with an antibottom quark or light quark, without the antiparticle top-q

  9. 40 CFR 164.81 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Evidence. 164.81 Section 164.81 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS RULES OF PRACTICE GOVERNING HEARINGS, UNDER THE FEDERAL INSECTICIDE, FUNGICIDE, AND RODENTICIDE ACT, ARISING FROM REFUSALS...

  10. Evidence-based recommendation on toothpaste use.

    Science.gov (United States)

    Cury, Jaime Aparecido; Tenuta, Livia Maria Andalo

    2014-01-01

    Toothpaste can be used as a vehicle for substances to improve the oral health of individuals and populations. Therefore, it should be recommended based on the best scientific evidence available, and not on the opinion of authorities or specialists. Fluoride is the most important therapeutic substance used in toothpastes, adding to the effect of mechanical toothbrushing on dental caries control. The use of fluoride toothpaste to reduce caries in children and adults is strongly based on evidence, and is dependent on the concentration (minimum of 1000 ppm F) and frequency of fluoride toothpaste use (2'/day or higher). The risk of dental fluorosis due to toothpaste ingestion by children has been overestimated, since there is no evidence that: 1) fluoride toothpaste use should be postponed until the age of 3-4 or older, 2) low-fluoride toothpaste avoids fluorosis and 3) fluorosis has a detrimental effect on the quality of life of individuals exposed to fluoridated water and toothpaste. Among other therapeutic substances used in toothpastes, there is evidence that triclosan/copolymer reduce dental biofilm, gingivitis, periodontitis, calculus and halitosis, and that toothpastes containing stannous fluoride reduce biofilm and gingivitis.

  11. 12 CFR 308.36 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Uniform Rules of Practice and Procedure § 308.36 Evidence. (a) Admissibility. (1) Except as is..., outlines or other graphic material to summarize, illustrate, or simplify the presentation of...

  12. 42 CFR 93.208 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Evidence. 93.208 Section 93.208 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  13. Digital Natives: Where Is the Evidence?

    Science.gov (United States)

    Helsper, Ellen Johanna; Eynon, Rebecca

    2010-01-01

    Generational differences are seen as the cause of wide shifts in our ability to engage with technologies and the concept of the digital native has gained popularity in certain areas of policy and practice. This paper provides evidence, through the analysis of a nationally representative survey in the UK, that generation is only one of the…

  14. Evidence Based Education Request Desk. EBE #359

    Science.gov (United States)

    Regional Educational Laboratory Southeast, 2008

    2008-01-01

    This Evidence Based Education (EBE) response describes characteristics of graduation coach initiatives in three states (Georgia, Alabama, and California). Regional Educational Laboratory (REL) Southeast has received over 19 requests for information on various initiatives, programs or research related to improving graduation rates. For example, the…

  15. Evidence Based Education Request Desk. EBE #555

    Science.gov (United States)

    Regional Educational Laboratory Southeast, 2009

    2009-01-01

    This Evidence Based Education (EBE) Request seeks to provide an overview of recent research regarding school improvement and reform with special concentration on turning around chronically low-performing schools. The response is divided into four main sections: Research on Effective Methods for Turning Around Low-Performing Schools, Frameworks for…

  16. Evidence Based Education Request Desk. EBE #510

    Science.gov (United States)

    Regional Educational Laboratory Southeast, 2009

    2009-01-01

    This Evidence Based Education (EBE) request focused on research-supported vocabulary interventions for middle elementary students. Limited vocabulary is an important factor in underachievement of children in disadvantaged homes. Children with larger vocabularies find reading easier, read more widely, and do better in school (Lubliner & Smetana,…

  17. Evidence Based Education Request Desk. EBE #741

    Science.gov (United States)

    Regional Educational Laboratory Southeast, 2010

    2010-01-01

    This Evidence Based Education (EBE) request asks for information relating to funding for virtual schools. The EBE Request Desk was asked to provide a scan of states for information on how they fund virtual schools and what the current funding levels are (most current year for which such data is available). This paper provides answers to this…

  18. Evidence Based Education Request Desk. EBE #798

    Science.gov (United States)

    Regional Educational Laboratory Southeast, 2011

    2011-01-01

    Evidence Based Education (EBE) #555 was in response to the request "Is there any new compelling research for turning around low-performing schools?" The articles included in that document are on target, but include articles through 2009. This EBE Request seeks to provide an updated review of recent research (2009-present) regarding school…

  19. Evidence-Based Treatment of Maisonneuve Fractures

    NARCIS (Netherlands)

    S.A. Stufkens; M.P.J. van den Bekerom; J.N. Doornberg; C.N. van Dijk; P. Kloen

    2011-01-01

    The objective of the current study was to review the published clinical evidence available for the treatment of Maisonneuve fractures. Medline via PubMed, Orthopaedic Trauma Association (OTA) annual meetings' abstracts archives Web site, Embase, the Cochrane Database of Systematic Reviews, and the C

  20. 19 CFR 210.37 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Evidence. 210.37 Section 210.37 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE... retained with the record so as to be available for consideration by any reviewing authority....

  1. 31 CFR 306.101 - Evidence required.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Evidence required. 306.101 Section 306.101 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT GENERAL REGULATIONS GOVERNING...

  2. Fossil evidence of the zygomycetous fungi

    NARCIS (Netherlands)

    Krings, M.; Taylor, T.N.; Dotzler, N.

    2013-01-01

    Molecular clock data indicate that the first zygomycetous fungi occurred on Earth during the Precambrian, however, fossil evidence of these organisms has been slow to accumulate. In this paper, the fossil record of the zygomycetous fungi is compiled, with a focus on structurally preserved Carbonifer

  3. Evidence-based Medicine in Animal Reproduction.

    Science.gov (United States)

    Arlt, S P; Heuwieser, W

    2014-09-01

    With new knowledge being generated and published daily, the importance of evidence-based approaches in veterinary medicine is obvious. Clinicians must stay current or risk making poor decisions that clients may challenge. Especially in animal reproduction, several new substances and procedures to diagnose or treat reproductive disorders have been introduced in the last years. On the other hand, a closer look at the quality of published literature on animal reproduction reveals major deficits in methodology and reporting of many clinical trials. We strongly recommend systematically assessing the quality of scientific information when reading journal papers before using the given information in practice. The aim of evidence-based medicine (EBM) is to base the decisions in the practice of medicine on valid, clinically relevant research data. Therefore, we suggest that students should become familiar with the concepts of evidence-based veterinary medicine (EBVM) at the beginning of their veterinary education. Concepts and supporting tools such as checklists for literature assessment have been developed and validated. The purpose of this article is to review and discuss the importance of incorporating EBVM in animal reproduction. The need for further research that produces strong evidence in different fields of animal reproduction and better reporting of relevant study information is obvious.

  4. Level of evidence in hand surgery

    Directory of Open Access Journals (Sweden)

    Rosales Roberto S

    2012-12-01

    Full Text Available Abstract Background Few investigations have been done to analyze the level of evidence in journals related to hand surgery, compared to other related research fields. The objective of this study was to assess the level of evidence of the clinical research papers published in the Ibero-american (RICMA, the European (JHSE and American (JHSA Journals of Hand Surgery. Methods A total of 932 clinical research papers published between 2005 and 2009 (RICMA 60, JHSE 461, and JHSA 411 were reviewed. Two independent observers classified the level of evidence based on the Oxford International Classification, 5 being the lowest level and 1 the highest level. The observed frequencies of the level of evidence for each journal were compared with the expected frequencies by a chi-square (χ 2 test for categorical variables with a significance level of 0.05. Results Inter-observer agreement analysis showed a Kappa of 0.617. Intra-observer agreement analysis presented a Kappa of 0.66 for the observer 1, and a Kappa of 0.751 for the observer 2. More than 80% of the papers in RICMA and JHSE and a 67.6% in the JHSA presented a level of 4. No level 1 or 2 studies were published in RICMA, compared to JHSE (0.9% level 1 and 5.0% level 2 and JHSA (8.3% level 1 and 10% level 2. The percentage of papers with level 3 published in RICMA (16.7% was higher compared to the JHSE (11.1% and the JHSA (14.1%. All the results were statistically significant (χ2=63.945; p Conclusions The level of evidence in hand surgery is dependent on the type of journal; being the highest level evidence papers those published in the JHSA, followed by the JHSE and finally the RICMA. Knowing the status of the level of evidence published in hand surgery is the starting point to face the challenges of improving the quality of our clinical research

  5. Micronutrients and cancer aetiology: the epidemiological evidence.

    Science.gov (United States)

    Key, T

    1994-11-01

    Micronutrient deficiencies occur most commonly in poor countries and, therefore, are most likely to be associated with cancers common in these countries. Epidemiological studies are hampered by inaccurate measurement of micronutrient intake and by the correlations between intakes of many nutrients. The strongest evidence for a protective effect of micronutrients is for oesophageal cancer. The identity of the micronutrients is not certain, but may include retinol, riboflavin, ascorbic acid and Zn; alcohol, smoking and dietary nitrosamines increase the risk for oesophageal cancer. For stomach cancer there is good evidence that fruit and vegetables are protective. The protective effect of these foods might be largely due to ascorbic acid, but other nutrients and non-nutrients may also be important; the risk for stomach cancer is increased by salt, some types of preserved foods, and by infection of the stomach with the bacterium Helicobacter pylori. The risk for lung cancer appears to be reduced by a high intake of fruit and vegetables, but it is not clear which agents are responsible and the major cause of lung cancer is cigarette smoking. Diet is probably the major determinant of the risk for colo-rectal cancer; there is evidence that fruit and vegetables and fibre reduce risk and that meat and animal fat increase risk, but there is no convincing evidence that these relationships are mediated by micronutrients. The risk for cervical cancer is inversely related to fruit and vegetable consumption and, therefore, to consumption of carotenoids and ascorbic acid, but the major cause of this cancer is human papillomavirus and it is not yet clear whether the dietary associations indicate a true protective effect or whether they are due to confounding by other variables. The evidence that micronutrients are important in the aetiology of either breast cancer or prostate cancer is weak, but the possible roles of 1,25-dihydroxycholecalciferol and alpha-tocopherol in prostate

  6. Nutrition and sarcopenia: evidence for an interaction.

    Science.gov (United States)

    Millward, D Joe

    2012-11-01

    Nutritional interventions that might influence sarcopenia, as indicated by literature reporting on sarcopenia per se as well as dynapenia and frailty, are reviewed in relation to potential physiological aetiological factors, i.e. inactivity, anabolic resistance, inflammation, acidosis and vitamin D deficiency. As sarcopenia occurs in physically active and presumably well-nourished populations, it is argued that a simple nutritional aetiology is unlikely and unequivocal evidence for any nutritional influence is extremely limited. Dietary protein is probably the most widely researched nutrient but only for frailty is there one study showing evidence of an aetiological influence and most intervention studies with protein or amino acids have proved ineffective with only a very few exceptions. Fish oil has been shown to attenuate anabolic resistance of muscle protein synthesis in one study. There is limited evidence for a protective influence of antioxidants and inducers of phase 2 proteins on sarcopenia, dynapenia and anabolic resistance in human and animal studies. Also fruit and vegetables may protect against acidosis-induced sarcopenia through their provision of dietary potassium. While severe vitamin D deficiency is associated with dynapenia and sarcopenia, the evidence for a beneficial influence of increasing vitamin D status above the severe deficiency level is limited and controversial, especially in men. On this basis there is insufficient evidence for any more specific nutritional advice than that contained in the general healthy lifestyle-healthy diet message: i.e. avoiding inactivity and low intakes of food energy and nutrients and maintain an active lifestyle with a diet providing a rich supply of fruit and vegetables and frequent oily fish.

  7. Evidence and evidence gaps in therapies of nasal obstruction and rhinosinusitis

    Science.gov (United States)

    Rotter, Nicole

    2016-01-01

    Therapeutic decisions in otorhinolaryngology are based on clinical experience, surgical skills, and scientific evidence. Recently, evidence-based therapies have gained increased attention and importance due to their potential to improve the individual patient’s treatment and their potential at the same time to reduce treatment costs. In clinical practice, it is almost impossible to stay ahead of the increasing mass of literature and on the other hand critically assess the presented data. A solid scientific and statistical knowledge as well as a significant amount of spare time are required to detect systematic bias and other errors in study designs, also with respect to assessing whether or not a study should be part of an individual therapeutic decision. Meta-analyses, reviews, and clinical guidelines are, therefore, of increasing importance for evidence-based therapy in clinical practice. This review is an update of the availability of external evidence for the treatment of nasal obstruction and rhinosinusitis. It becomes evident that both groups of diseases differ significantly in the availability of external evidence. Furthermore, it becomes obvious that surgical treatment options are normally based on evidence of significantly lower quality than medical treatment options. PMID:28025606

  8. Can Scholarly Communication be Evidence Based? (Editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2010-12-01

    Full Text Available This issue of Evidence Based Library and Information Practice includes three papers from the Evidence Based Scholarly Communication Conference (EBSCC that took place in March 2010i. Kroth, Philips and Eldredge have written a commentary that gives an overview of the conference, and introduces us to the research papers that were presented. As well, two research presentations from the conference appear in this issue, an article by Donahue about a potential new method of communicating between scholars, and a paper by Gilliland in our Using Evidence in Practice section, detailing a library’s Open Access Day preparations.Kroth, Philips and Eldredge note that “The EBSCC brought together librarians and information specialists to share evidence-based strategies for developing effective local scholarly communication support and training and, hopefully, form new coalitions to address this topic at a local and national level.” (p 108. This conference focused on translational medicine, and looked at how to promote new methods of scholarly communication, partially through the inclusion of research papers at the conference.The inclusion of these articles and the evidence based focus of the EBSCC conference, made me ask myself, can scholarly communication be evidence based? At its core, scholarly communication is anything but a scientific issue. It is charged with emotion; from authors, publishers, librarians and others involved in the business of publishing. The recent shift to look at new models of scholarly communication has been a threat to many of the established models and sparked much debate in the academic world, especially in relation to open access. In her 2006 EBLIP commentary on evidence based practice and open access, Morrison notes, “Open Access and evidence based librarianship are a natural combination” (p. 49, and outlines her perspective on many of the reasons why. Debate continues to rage, however, regarding how authors should

  9. Empirical methods for systematic reviews and evidence-based medicine

    NARCIS (Netherlands)

    van Enst, W.A.

    2014-01-01

    Evidence-Based Medicine is the integration of best research evidence with clinical expertise and patient values. Systematic reviews have become the cornerstone of evidence-based medicine, which is reflected in the position systematic reviews have in the pyramid of evidence-based medicine. Systematic

  10. 20 CFR 220.45 - Providing evidence of disability.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Providing evidence of disability. 220.45... DETERMINING DISABILITY Evidence of Disability § 220.45 Providing evidence of disability. (a) General. The claimant for a disability annuity is responsible for providing evidence of the claimed disability and...

  11. Evidence Based Education: un quadro storico

    Directory of Open Access Journals (Sweden)

    Giuliano Vivanet

    2013-08-01

    Full Text Available Nel corso dell’ultimo decennio, nel pensiero pedagogico anglosassone, si è affermata una cultura dell’evidenza cui ci si riferisce con l’espressione “evidence based education” (EBE. Secondo tale prospettiva, le decisioni in ambito educativo dovrebbero essere assunte sulla base delle conoscenze che la ricerca empirica offre in merito alla minore o maggiore efficacia delle differenti opzioni didattiche. Si tratta di un approccio (denominato “evidence based practice” che ha origine in ambito medico e che in seguito ha trovato applicazione in differenti domini delle scienze sociali. L’autore presenta un quadro introduttivo all’EBE, dando conto delle sue origini e dei differenti significati di cui è portatrice.

  12. Evidence-Based Education in Plastic Surgery.

    Science.gov (United States)

    Johnson, Shepard P; Chung, Kevin C; Waljee, Jennifer F

    2015-08-01

    Educational reforms in resident training have historically been driven by reports from medical societies and organizations. Although educational initiatives are well intended, they are rarely supported by robust evidence. The Accreditation Council for Graduate Medical Education recently introduced competency-based training, a form of outcomes-based education that has been used successfully in nonmedical professional vocations. This initiative has promise to advance the quality of resident education, but questions remain regarding implementation within plastic surgery. In particular, how will competency-based training impact patient outcomes, and will the methodologies used to assess competencies (i.e., milestones) be accurate and validated by literature? This report investigates resident educational reform and the need for more evidence-based educational initiatives in plastic surgery training.

  13. Explicit Evidence Systems with Common Knowledge

    CERN Document Server

    Bucheli, Samuel; Studer, Thomas

    2010-01-01

    Justification logics are epistemic logics that explicitly include justifications for the agents' knowledge. We develop a multi-agent justification logic with evidence terms for individual agents as well as for common knowledge. We define a Kripke-style semantics that is similar to Fitting's semantics for the Logic of Proofs LP. We show the soundness, completeness, and finite model property of our multi-agent justification logic with respect to this Kripke-style semantics. We demonstrate that our logic is a conservative extension of Yavorskaya's minimal bimodal explicit evidence logic, which is a two-agent version of LP. We discuss the relationship of our logic to the multi-agent modal logic S4 with common knowledge. Finally, we give a brief analysis of the coordinated attack problem in the newly developed language of our logic.

  14. Evidence for trends in UK flooding.

    Science.gov (United States)

    Robson, Alice J

    2002-07-15

    Recent major flooding in the UK has raised concern that climate change is causing increases in flood frequency and flood magnitude. This paper considers whether UK flood data provide evidence of increasing trends in fluvial floods. The analysis examines both local and national flood series and investigates the effect of climate variability on trend detection. The results suggest that there have been trends towards more protracted high flows over the last 30-50 years, but that this could be accounted for as part of climatic variation rather than climate change. There is no statistical evidence of a long-term trend in flooding over the last 80-120 years. Thus, although climate change could be influencing floods, direct analysis of flood records does not yet provide proof.

  15. Suicide among animals: a review of evidence.

    Science.gov (United States)

    Preti, Antonio

    2007-12-01

    Naturalists have not identified suicide in nonhuman species in field situations, despite intensive study of thousands of animal species. In this review, evidence on suicidal behavior among animals is analyzed to discover analogies with human suicidal behavior. Literature was retrieved by exploring Medline/PubMed and PsychINFO databases (1967-2007) and through manual literature searches. Keyword terms were "suicide or suicidal behavior" and "animal or animal behavior." Few empirical investigations have been carried out on this topic. Nevertheless, sparse evidence supports some resemblance between the self-endangering behavior observed in the animal kingdom, particularly in animals held in captivity or put under pressure by environmental challenges, and suicidal behavior among humans. Animal models have contributed to the study of both normal and pathological human behaviors: discovering some correlates of suicide among animals could be a valid contribution to the field.

  16. Digital Evidence Education in Schools of Law

    Directory of Open Access Journals (Sweden)

    Aaron Alva

    2012-06-01

    Full Text Available An examination of State of Connecticut v. Julie Amero provides insight into how a general lack of understanding of digital evidence can cause an innocent defendant to be wrongfully convicted. By contrast, the 101-page opinion in Lorraine v. Markel American Insurance Co. provides legal precedence and a detailed consideration for the admission of digital evidence. An analysis of both cases leads the authors to recommend additions to Law School curricula designed to raise the awareness of the legal community to ensure such travesties of justice, as in the Amero case, don’t occur in the future. Work underway at the University of Washington designed to address this deficiency is discussed.

  17. Evidence-based management of ANCA vasculitis.

    Science.gov (United States)

    Carruthers, David; Sherlock, Jonathan

    2009-06-01

    The vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs) present to and are managed by a wide spectrum of physicians, reflecting the multi-organ nature of the conditions. Treatment strategies for these primary inflammatory vascular diseases have varied based on the outcomes of different clinical trials and practice reviews. The individual drugs used and their route of administration, dose, and duration of therapy have varied and have been the source of much debate. Advances in our understanding of disease immunopathogenesis, clinical assessment and outcome have formed the basis for several recent good-quality clinical trials. Now, with the results of these large-scale multicentre collaborative studies, there is a firmer evidence base to guide management decisions for individual patients. This evidence base, reviewed here, has led to the publication of treatment guidelines which importantly encompass many of the broader aspects of disease management.

  18. Evidence for D0-D0 mixing.

    Science.gov (United States)

    Aubert, B; Bona, M; Boutigny, D; Karyotakis, Y; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Grauges, E; Lopez, L; Palano, A; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lopes Pegna, D; Lynch, G; Mir, L M; Orimoto, T J; Ronan, M T; Tackmann, K; Wenzel, W A; Del Amo Sanchez, P; Hawkes, C M; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Schroeder, T; Steinke, M; Walker, D; Asgeirsson, D J; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Liu, F; Long, O; Shen, B C; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Williams, D C; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Brandt, T; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Lombardo, V; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Flack, R L; Nash, J A; Nikolich, M B; Panduro Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Béquilleux, J; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, A M; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flaecher, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Salvati, E; Saremi, S; Cowan, R; Fisher, P H; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; De Nardo, G; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Ter-Antonyan, R; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; de la Vaissière, Ch; Hamon, O; Leruste, Ph; Malclès, J; Ocariz, J; Perez, A; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Biesiada, J; Elmer, P; Lau, Y P; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Bellini, F; Cavoto, G; D'Orazio, A; del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, E O; Ricciardi, S; Roethel, W; Wilson, F F; Aleksan, R; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Legendre, M; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Hryn'ova, T; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Muller, D R; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; van Bakel, N; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H

    2007-05-25

    We present evidence for D0-D(0) mixing in D(0)-->K(+)pi(-) decays from 384 fb(-1) of e(+)e(-) colliding-beam data recorded near square root s=10.6 GeV with the BABAR detector at the PEP-II storage rings at the Stanford Linear Accelerator Center. We find the mixing parameters x('2)=[-0.22+/-0.30(stat)+/-0.21(syst)] x 10(-3) and y(')=[9.7+/-4.4(stat)+/-3.1(syst)] x 10(-3) and a correlation between them of -0.95. This result is inconsistent with the no-mixing hypothesis with a significance of 3.9 standard deviations. We measure R(D), the ratio of doubly Cabibbo-suppressed to Cabibbo-favored decay rates, to be [0.303+/-0.016(stat)+/-0.010(syst)]%. We find no evidence for CP violation.

  19. Creative teaching an evidence-based approach

    CERN Document Server

    Sale, Dennis

    2015-01-01

    This book contains an evidence-based pedagogic guide to enable any motivated teaching/training professional to be able to teach effectively and creatively. It firstly summarises the extensive research field on human psychological functioning relating to learning and how this can be fully utilised in the design and facilitation of quality learning experiences. It then demonstrates what creativity actually 'looks like' in terms of teaching practices, modelling the underpinning processes of creative learning design and how to apply these in lesson planning. The book, having established an evidence-based and pedagogically driven approach to creative learning design, extensively focuses on key challenges facing teaching professionals today. These include utilising information technologies in blended learning formats, differentiating instruction, and developing self-directed learners who can think well. The main purpose of the book is to demystify what it means to teach creatively, explicitly demonstrating the pr...

  20. Ancient bacteria show evidence of DNA repair

    DEFF Research Database (Denmark)

    Johnson, Sarah Stewart; Hebsgaard, Martin B; Christensen, Torben R

    2007-01-01

    Recent claims of cultivable ancient bacteria within sealed environments highlight our limited understanding of the mechanisms behind long-term cell survival. It remains unclear how dormancy, a favored explanation for extended cellular persistence, can cope with spontaneous genomic decay over......-term survival of bacteria sealed in frozen conditions for up to one million years. Our results show evidence of bacterial survival in samples up to half a million years in age, making this the oldest independently authenticated DNA to date obtained from viable cells. Additionally, we find strong evidence...... that this long-term survival is closely tied to cellular metabolic activity and DNA repair that over time proves to be superior to dormancy as a mechanism in sustaining bacteria viability....

  1. Limited Evidence for Robot-assisted Surgery

    DEFF Research Database (Denmark)

    Broholm, Malene; Onsberg Hansen, Iben; Rosenberg, Jacob

    2016-01-01

    PURPOSE: To evaluate available evidence on robot-assisted surgery compared with open and laparoscopic surgery. METHOD: The databases Medline, Embase, and Cochrane Library were systematically searched for randomized controlled trials comparing robot-assisted surgery with open and laparoscopic...... surgery regardless of surgical procedure. Meta-analyses were performed on each outcome with appropriate data material available. Cochrane Collaboration's tool for assessing risk of bias was used to evaluate risk of bias on a study level. The GRADE approach was used to evaluate the quality of evidence...... of the meta-analyses. RESULTS: This review included 20 studies comprising 981 patients. The meta-analyses found no significant differences between robot-assisted and laparoscopic surgery regarding blood loss, complication rates, and hospital stay. A significantly longer operative time was found for robot...

  2. Distinction between forensic evidence and dermatological findings.

    Science.gov (United States)

    Hammer, U; Boy, D; Rothaupt, D; Büttner, A

    2015-07-01

    The external examination after death requires knowledge in forensics/pathology, dermatology, as well as associated diseases and age-related alterations of the skin. This article highlights some findings with forensic evidence versus dermatological findings. The lectures in forensic medicine should be structured interdisciplinarily, especially to dermatology, internal medicine, surgery, pathology, and toxicology in order to train the overlapping skills required for external and internal postmortem examinations.

  3. Analysis of evidence of Mars life

    CERN Document Server

    Levin, Gilbert V

    2007-01-01

    Gillevinia straata, the scientific name [1, 2] recognizing the first extraterrestrial living form ever nomenclated, as well as the existence of a new biological kingdom, Jakobia, in a new biosphere -Marciana- of what now has become the living system Solaria, is grounded on old evidence reinterpreted in the light of newly acquired facts. The present exposition provides a summary overview of all these grounds, outlined here as follows. A more detailed paper is being prepared for publication.

  4. Segmentation of respiratory signals by evidence theory.

    Science.gov (United States)

    Belghith, Akram; Collet, Christophe

    2009-01-01

    This paper presents an evidential segmentation scheme of respiratory signals for the detection of the wheezing sounds. The segmentation is based on the modeling of the data by evidence theory which is well suited to represent such uncertain and imprecise data. In this paper, we particularly focus on the modelization of the data imprecision using the fuzzy theory. The modelization result is then used to define the mass function. The effectiveness of the method is demonstrated on synthetic and real signals.

  5. Evidence Regarding the Treatment of Denture Stomatitis.

    Science.gov (United States)

    Yarborough, Alexandra; Cooper, Lyndon; Duqum, Ibrahim; Mendonça, Gustavo; McGraw, Kathleen; Stoner, Lisa

    2016-06-01

    Denture stomatitis is a common inflammatory condition affecting the mucosa underlying complete dentures. It is associated with denture microbial biofilm, poor denture hygiene, poor denture quality, and nocturnal denture use. Numerous treatment methodologies have been used to treat stomatitis; however, a gold standard treatment has not been identified. The aim of this systematic review is to report on the current knowledge available in studies representing a range of evidence on the treatment of denture stomatitis.

  6. Computational mate choice: theory and empirical evidence.

    Science.gov (United States)

    Castellano, Sergio; Cadeddu, Giorgia; Cermelli, Paolo

    2012-06-01

    The present review is based on the thesis that mate choice results from information-processing mechanisms governed by computational rules and that, to understand how females choose their mates, we should identify which are the sources of information and how they are used to make decisions. We describe mate choice as a three-step computational process and for each step we present theories and review empirical evidence. The first step is a perceptual process. It describes the acquisition of evidence, that is, how females use multiple cues and signals to assign an attractiveness value to prospective mates (the preference function hypothesis). The second step is a decisional process. It describes the construction of the decision variable (DV), which integrates evidence (private information by direct assessment), priors (public information), and value (perceived utility) of prospective mates into a quantity that is used by a decision rule (DR) to produce a choice. We make the assumption that females are optimal Bayesian decision makers and we derive a formal model of DV that can explain the effects of preference functions, mate copying, social context, and females' state and condition on the patterns of mate choice. The third step of mating decision is a deliberative process that depends on the DRs. We identify two main categories of DRs (absolute and comparative rules), and review the normative models of mate sampling tactics associated to them. We highlight the limits of the normative approach and present a class of computational models (sequential-sampling models) that are based on the assumption that DVs accumulate noisy evidence over time until a decision threshold is reached. These models force us to rethink the dichotomy between comparative and absolute decision rules, between discrimination and recognition, and even between rational and irrational choice. Since they have a robust biological basis, we think they may represent a useful theoretical tool for

  7. Marital assortment and phenotypic convergence: longitudinal evidence.

    Science.gov (United States)

    Caspi, A; Herbener, E S

    1993-01-01

    This study provides a direct test of whether the observed similarity of spouses is due to initial assortment rather than to convergence of phenotypes. With data from three well-known longitudinal studies, phenotypic convergence is examined using both variable- and person-centered analyses. The longitudinal evidence does not support the hypothesis that couples increasingly resemble each other with time. Spouse correlations most likely reflect initial assortment at marriage and not the convergence of phenotypes.

  8. Education and agricultural productivity: evidence from Uganda

    OpenAIRE

    1996-01-01

    Existing evidence on the impact of education on agricultural productivity in Africa is mixed, with estimates usually insignificant although sometimes large. Analysis of the first nationally representative household survey of Uganda gives an estimate of the impact of household primary schooling on crop production comparable to the developing country average. In addition, the primary schooling of neighbouring farm workers appears to raise crop production and these external returns exceed the in...

  9. Afterword: Strands of Evidence in Later Prehistory

    Directory of Open Access Journals (Sweden)

    Melanie Giles

    2016-11-01

    Full Text Available What is it about hair that helps humanise the dead, particularly these well-preserved bog bodies who are so often the victims of violence? As the articles in this special volume of Internet Archaeology make clear, hair is an exquisitely rich source of evidence on origin, diet and health as well as social traditions. Yet the meaning of hair can vary greatly between times and cultures.

  10. How to teach evidence-based surgery.

    Science.gov (United States)

    Fingerhut, Abe; Borie, Frédéric; Dziri, Chadli

    2005-05-01

    The objectives of teaching evidence-based surgery (EBS) are to inform and convince that EBS is a method of interrogation, reasoning, appraisal, and application of information to guide physicians in their decisions to best treat their patients. Asking the right, answerable questions, translating them into effective searches for the best evidence, critically appraising evidence for its validity and importance, and then integrating EBS with their patients' values and preferences are daily chores for all surgeons. Teaching and learning EBS should be patient-centered, learner-centered, and active and interactive. The teacher should be a model for students to become an expert clinician who is able to match and take advantage of the clinical setting and circumstances to ask and to answer appropriate questions. The process is multistaged. Teaching EBS in small groups is ideal. However, it is time-consuming for the faculty and must be clearly and formally structured. As well, evidence-based medicine (EBM) courses must cater to local institutional needs, must receive broad support from the instructors and the providers of information (librarians and computer science faculty), use proven methodologies, and avoid scheduling conflicts. In agreement with others, we believe that the ideal moment to introduce the concepts of EBM into the curriculum of the medical student is early, during the first years of medical school. Afterward, it should be continued every year. When this is not the case, as in many countries, it becomes the province of the surgeon in teaching hospitals, whether they are at the university, are university-affiliated, or not, to fulfill this role.

  11. Rational Addiction Evidence From Carbonated Soft Drinks

    OpenAIRE

    Xiaoou, Liu

    2009-01-01

    This paper applies the Becker-Murphy (1988) theory of rational addiction to the case of carbonated soft drinks, using a time-varying parameter model and scanner data from 46 U.S. cities. Empirical results provide strong evidence that carbonated soft drinks are rationally addictive, thus opening the door to taxation and regulation. Taking rational addition into account, estimated demand elasticities are much lower than previous estimates using scanner data.

  12. [Evidence-Based Knowledge Translation: From Scientific Evidence to Clinical Nursing Practice].

    Science.gov (United States)

    Chen, Kee-Hsin; Kao, Ching-Chiu; Chen, Chiehfeng

    2016-12-01

    In 1992, Gordon Guyatt coined the term "evidence-based medicine", which has since attracted worldwide attention. In 2007, the Institute of Medicine's Roundtable on Evidence-Based Medicine set the goal that 90% of clinical decisions would be supported by accurate, timely, and up-to-date clinical information and would reflect the best available evidence by 2020. However, the chasm between knowing and doing remains palpable. In 2000, the Canadian Institute of Health Research applied the term "knowledge translation" to describe the bridge that is necessary to cross the gap between research knowledge and clinical practice. The present paper outlines the conceptual framework, barriers, and promotion strategies for evidence-based knowledge translation and shares clinical experience related to overcoming the seven layers of leakage (aware, accepted, applicable, able, acted on, agreed, and adhered to). We hope that this paper can enhance the public well-being and strengthen the future health care system.

  13. Evidence that consumers are skeptical about evidence-based health care.

    Science.gov (United States)

    Carman, Kristin L; Maurer, Maureen; Yegian, Jill Mathews; Dardess, Pamela; McGee, Jeanne; Evers, Mark; Marlo, Karen O

    2010-07-01

    We undertook focus groups, interviews, and an online survey with health care consumers as part of a recent project to assist purchasers in communicating more effectively about health care evidence and quality. Most of the consumers were ages 18-64; had health insurance through a current employer; and had taken part in making decisions about health insurance coverage for themselves, their spouse, or someone else. We found many of these consumers' beliefs, values, and knowledge to be at odds with what policy makers prescribe as evidence-based health care. Few consumers understood terms such as "medical evidence" or "quality guidelines." Most believed that more care meant higher-quality, better care. The gaps in knowledge and misconceptions point to serious challenges in engaging consumers in evidence-based decision making.

  14. 2013 Nutrition Risk Evidence Review Panel. Evidence Review for: The Risk Factor of Inadequate Nutrition

    Science.gov (United States)

    2014-01-01

    The 2013 Nutrition Risk Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on November 20 - 21, 2013. The SRP reviewed the new Evidence Report for the Risk Factor of Inadequate Nutrition (from here on referred to as the 2013 Nutrition Evidence Report), as well as the Research Plan for this Risk. Overall, the SRP thinks the well-qualified research team has compiled an excellent summary of background information in the 2013 Nutrition Evidence Report. The SRP would like to commend the authors in general and particularly note that while the 2013 Nutrition Evidence Report has been written using a single nutrient approach, the research plan takes a much more integrated and physiologically based approach.

  15. Evidence based psychosocial interventions in substance use

    Directory of Open Access Journals (Sweden)

    Sonali Jhanjee

    2014-01-01

    Full Text Available In recent years, there has been significant progress and expansion in the development of evidence-based psychosocial treatments for substance abuse and dependence. A literature review was undertaken using the several electronic databases (PubMed, Cochrane Database of systemic reviews and specific journals, which pertain to psychosocial issues in addictive disorders and guidelines on this topic. Overall psychosocial interventions have been found to be effective. Some interventions, such as cognitive behavior therapy, motivational interviewing and relapse prevention, appear to be effective across many drugs of abuse. Psychological treatment is more effective when prescribed with substitute prescribing than when medication or psychological treatment is used alone, particularly for opiate users. The evidence base for psychological treatment needs to be expanded and should also include research on optimal combinations of psychological therapies and any particular matching effects, if any. Psychological interventions are an essential part of the treatment regimen and efforts should be made to integrate evidence-based interventions in all substance use disorder treatment programs.

  16. Sequential evidence accumulation in decision making

    Directory of Open Access Journals (Sweden)

    Daniel Hausmann

    2008-03-01

    Full Text Available Judgments and decisions under uncertainty are frequently linked to a prior sequential search for relevant information. In such cases, the subject has to decide when to stop the search for information. Evidence accumulation models from social and cognitive psychology assume an active and sequential information search until enough evidence has been accumulated to pass a decision threshold. In line with such theories, we conceptualize the evidence threshold as the ``desired level of confidence'' (DLC of a person. This model is tested against a fixed stopping rule (one-reason decision making and against the class of multi-attribute information integrating models. A series of experiments using an information board for horse race betting demonstrates an advantage of the proposed model by measuring the individual DLC of each subject and confirming its correctness in two separate stages. In addition to a better understanding of the stopping rule (within the narrow framework of simple heuristics, the results indicate that individual aspiration levels might be a relevant factor when modelling decision making by task analysis of statistical environments.

  17. Evidence of sound symbolism in simple vocalizations.

    Science.gov (United States)

    Parise, Cesare V; Pavani, Francesco

    2011-10-01

    The question of the arbitrariness of language is among the oldest in cognitive sciences, and it relates to the nature of the associations between vocal sounds and their meaning. Growing evidence seems to support sound symbolism, claiming for a naturally constrained mapping of meaning into sounds. Most of such evidence, however, comes from studies based on the interpretation of pseudowords, and to date, there is little empirical evidence that sound symbolism can affect phonatory behavior. In the present study, we asked participants to utter the letter /a/ in response to visual stimuli varying in shape, luminance, and size, and we observed consistent sound symbolic effects on vocalizations. Utterances' loudness was modulated by stimulus shape and luminance. Moreover, stimulus shape consistently modulated the frequency of the third formant (F3). This finding reveals an automatic mapping of specific visual attributes into phonological features of vocalizations. Furthermore, it suggests that sound-meaning associations are reciprocal, affecting active (production) as well as passive (comprehension) linguistic behavior.

  18. Evidence-based pathology: umbilical cord coiling.

    Science.gov (United States)

    Khong, T Y

    2010-12-01

    The generation of a pathology test result must be based on criteria that are proven to be acceptably reproducible and clinically relevant to be evidence-based. This review de-constructs the umbilical cord coiling index to illustrate how it can stray from being evidence-based. Publications related to umbilical cord coiling were retrieved and analysed with regard to how the umbilical coiling index was calculated, abnormal coiling was defined and reference ranges were constructed. Errors and other influences that can occur with the measurement of the length of the umbilical cord or of the number of coils can compromise the generation of the coiling index. Definitions of abnormal coiling are not consistent in the literature. Reference ranges defining hypocoiling or hypercoiling have not taken those potential errors or the possible effect of gestational age into account. Even the way numerical test results in anatomical pathology are generated, as illustrated by the umbilical coiling index, warrants a critical analysis into its evidence base to ensure that they are reproducible or free from errors.

  19. Ramadan fasting: Do we need more evidence?

    Directory of Open Access Journals (Sweden)

    Mohsen Nematy

    2015-03-01

    Full Text Available Over a billion of Muslims fast worldwide during Ramadan each year. Through this religious custom, fasting contributes to their health as well as their spiritual growth. However, available evidence regarding the health-benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many fast conceivably, and their clinical condition is prone to deteriorate due to persistent gap between current expert knowledge and conclusive strong evidence regarding the pathophysiologic and metabolic alterations of fasting and the consensus that should be taken into account to implements guided managing of various patient groups during Ramadan fasting among health care professionals. In this article, we summarized the results of initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition and clinically important outcomes of patients with a previous history of cardiovascular disease, asthma and renal colic disease. Our studies have shed light on several outcomes in favor of Ramadan fasting, and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. In this review we aimed to present a piece of relevant evidence, clarify future scope and provide suggestions for future investigations.

  20. [Prevention of atopic eczema. Evidence based guidelines].

    Science.gov (United States)

    Schäfer, T

    2005-03-01

    With an estimated prevalence of 12% for preschool children and 3% for adults, atopic eczema is a serious public health problem. This disease severely jeopardizes quality of life and is associated with considerable costs. Since there is still no causal therapy, primary and secondary prevention are especially important. Here the evidence basis for recommendations on prevention of atopic eczema is discussed on the basis of the first evidence-based consensus guideline (S3) on allergy prevention. This recommends that babies should be breastfed exclusively for at least 4 months and exposure to passive smoking be avoided even during pregnancy; restriction of the maternal diet during pregnancy has no influence, though during breastfeeding it can lower the incidence of eczema among babies at risk. Thereby this measure should be balanced with potential consequences of malnutrition. There seems to be a positive correlation between keeping small rodents (rabbits, guinea pigs), and possibly cats, and the occurrence of atopic eczema, while keeping dogs has no effect or even a protective effect. Avoidance of an unfavorable indoor climate is probably also helpful in preventing eczema. There is no evidence to support deviating from the current recommendations of the standing committee for vaccination.

  1. [Acupressure and Evidence-Based Nursing].

    Science.gov (United States)

    Chen, Li-Li; Lin, Jun-Dai

    2015-12-01

    Acupressure is a traditional Chinese medicine approach to disease prevention and treatment that may be operated by nurses independently. Therefore, acupressure is being increasingly applied in clinical nursing practice and research. Recently, the implementation of evidence-based nursing (EBN) in clinical practice has been encouraged to promote nursing quality. Evidence-based nursing is a method-ology and process of implementation that applies the best-available evidence to clinical practice, which is acquired through the use of empirical nursing research. Therefore, in this paper, we address the topic of acupressure within the context of empirical nursing practice. We first introduce the current status of acupressure research and provide the locations of common acupoints in order to guide future empirical nursing research and to help nurses use these acupoints in clinical practice. Finally, we describe the steps that are necessary to apply the current empirical information on acupressure as well as provide suggestions to promote safety and efficacy in order to guide nurses in the accurate application of acupressure in nursing practice.

  2. Economic Development and Population Growth. International Evidence Economic Development and Population Growth. International Evidence

    Directory of Open Access Journals (Sweden)

    Munir Quddus

    1986-03-01

    Full Text Available Economic Development and Population Growth. International Evidence The paper usses Granger causality tests on economic development and population growth for 44 countries to discriminate among several alternative hypotheses. The time series evidence does not provide an unambiguous picture as to the exact nature of the relationship. Therefore, previous attempts to generalize such relationship based on simple cross-section data are strongly suspect.

  3. Common pitfalls in statistical analysis: "No evidence of effect" versus "evidence of no effect"

    Directory of Open Access Journals (Sweden)

    Priya Ranganathan

    2015-01-01

    Full Text Available This article is the first in a series exploring common pitfalls in statistical analysis in biomedical research. The power of a clinical trial is the ability to find a difference between treatments, where such a difference exists. At the end of the study, the lack of difference between treatments does not mean that the treatments can be considered equivalent. The distinction between "no evidence of effect" and "evidence of no effect" needs to be understood.

  4. When Evidence Doesn’t Work (Editorial

    Directory of Open Access Journals (Sweden)

    Lindsay Glynn

    2007-12-01

    Full Text Available I was listening intently to a discussion on the radio recently between Newfoundland and Labrador’s Minister of Education and aprofessor from Memorial University’s Math Department. They were debating the efficacy of the math curriculum in the province’s school system. As a parent of a grade 3 student, I have my own thoughts on how the curriculum is affecting kids’ math skills (and their anxiety levels, but let’s not go there. The professor echoed the concern that parents, teachers and students have been expressing: quite simply, it’s not working. Far too many children are failing math and are struggling with the both the content and pace of the required modules. Why am I telling you this? One particular comment made by the Minister of Education struck me. She said that there was evidence to suggest that this curriculum should work. While I’m always delighted to see the evidence based practice model being used, particularly for the betterment of my kids’education, it is dismaying to see that it is not always applied well. In this particular case, evidence was collected from somewhere and a decision was made to implement a new math curriculum based on the gathered evidence. Assuming that this truly was good evidence upon which to base such a decision, then I would have to concede that the appropriate steps were taken up until that point. Unfortunately, it appears that the entire process stopped there. As we know, one of the most important components of a thorough ebp‐based implementation is an internal evaluation. What might work somewhere else is not guaranteed to work in another environment, and it is essential to determine why an implementation or intervention worked or didn’t work. It would seem, in this case, that formal evaluations of the effectiveness of the new math curriculum have not been performed and therefore, the powers that be rely solely on the fact that it worked somewhere else. This is not evidence based

  5. How to Reach Evidence-Based Usability Evaluation Methods.

    Science.gov (United States)

    Marcilly, Romaric; Peute, Linda

    2017-01-01

    This paper discusses how and why to build evidence-based knowledge on usability evaluation methods. At each step of building evidence, requisites and difficulties to achieve it are highlighted. Specifically, the paper presents how usability evaluation studies should be designed to allow capitalizing evidence. Reciprocally, it presents how evidence-based usability knowledge will help improve usability practice. Finally, it underlines that evaluation and evidence participate in a virtuous circle that will help improve scientific knowledge and evaluation practice.

  6. Ambulance officers' use of online clinical evidence

    Directory of Open Access Journals (Sweden)

    Westbrook Mary T

    2006-07-01

    Full Text Available Abstract Background Hospital-based clinicians have been shown to use and attain benefits from online evidence systems. To our knowledge there have been no studies investigating whether and how ambulance officers use online evidence systems if provided. We surveyed ambulance officers to examine their knowledge and use of the Clinical Information Access Program (CIAP, an online evidence system providing 24-hour access to information to support evidence-based practice. Methods A questionnaire was completed by 278 ambulance officers in New South Wales, Australia. Comparisons were made between those who used CIAP and officers who had heard of, but not used CIAP. Results Half the sample (48.6% knew of, and 28.8% had used CIAP. Users were more likely to have heard of CIAP from a CIAP representative/presentation, non-users from written information. Compared to ambulance officers who had heard of but had not used CIAP, users were more likely to report better computer skills and that their supervisors regarded use of CIAP as a legitimate part of ambulance officers' clinical role. The main reasons for non-use were lack of access(49.0% and training(31.4%. Of users, 51.3% rated their skills at finding information as good/very good, 67.5% found the information sought all/most of the time, 87.3% believed CIAP had the potential to improve patient care and 28.2% had directly experienced this. Most access to CIAP occurred at home. The databases frequently accessed were MIMS (A medicines information database (73.8% and MEDLINE(67.5%. The major journals accessed were Journal of Emergency Nursing(37.5%, American Journal of Medicine(30.0% and JAMA(27.5%. Conclusion Over half of ambulance officers had not heard of CIAP. The proportion who knew about and used CIAP was also low. Reasons for this appear to be a work culture not convinced of CIAP's relevance to pre-hospital patient care and lack of access to CIAP at work. Ambulance officers who used CIAP accessed it

  7. Teaching strategies to support evidence-based practice.

    Science.gov (United States)

    Winters, Charlene A; Echeverri, Rebecca

    2012-06-01

    Evidence-based practice is an expected core competency of all health care clinicians regardless of discipline. Use of evidence-based practice means integrating the best research with clinical expertise and patient values to achieve optimal health outcomes. Evidence-based practice requires nurses to access and appraise evidence rapidly before integrating it into clinical practice. Role modeling and integrating the skills necessary to develop evidence-based practice into clinical and nonclinical courses is an important part in developing positive attitudes toward evidence-based practice, an essential first step to using evidence to guide practice decisions. The step-by-step approach to evidence-based practice proposed by Melnyk and colleagues provides an excellent organizing framework for teaching strategies specifically designed to facilitate nurses' knowledge and skill development in evidence-based practice.

  8. Why be an evidence-based dentistry champion?

    Science.gov (United States)

    Clarkson, Jan E; Bonetti, Debbie

    2009-09-01

    Evidence-based dentistry champions are committed to improving the quality, effectiveness, and appropriateness of dental care through the application of evidence-based principles and tools. They share knowledge and skills to promote evidence-based dentistry (EBD) in practice, guiding colleagues, patients and policy makers in the application of critical thinking skills and evidence-based decision-making. Being an evidence-based champion requires furthering an understanding of the full process and the challenges of evidence based dentistry, including the development of an evidence base, evidence synthesis and summary, the creation of best practice guidelines, as well as evidence implementation. Efforts to improve the quality, effectiveness, and appropriateness of dental care need to occur at, and be coordinated across, multiple levels of dentistry, including the patient, clinician, team, organization, and policy.

  9. "Evidence" Under a Magnifying Glass: Thoughts on Safety Argument Epistemology

    Science.gov (United States)

    Graydon, P. J.; Holloway, C. M.

    2015-01-01

    Common definitions of "safety case" emphasize that evidence is the basis of a safety argument, yet few widely referenced works explicitly define "evidence". Their examples suggest that similar things can be regarded as evidence. But the category evidence seems to contain (1) processes for finding things out, (2) information resulting from such processes, and (3) relevant documents. Moreover, any item of evidence could be replaced by further argument. Normative models of informal argumentation do not offer clear guidance on when a safety argument should cite evidence rather than appeal to a more detailed argument. Disciplines such as the law address the problem with a practical, domain-specific epistemology. In this paper, we explore these problems associated with evidence citations in safety arguments, identify goals for a theory of safety argument evidence and a practical safety argument epistemology, propose a model of safety evidence citation that advances the identified goals, and present a related extension to the Goal Structuring Notation (GSN).

  10. Evidence for indications of fresh frozen plasma.

    Science.gov (United States)

    Stanworth, S J; Hyde, C J; Murphy, M F

    2007-12-01

    There continues to be a general but unfounded enthusiasm for fresh frozen plasma (FFP) usage across a range of clinical specialties in hospital practice. Clinical use of plasma has grown steadily over the last two decades in many countries. In England and Wales, there has not been a significant reduction in the use of FFP over the last few years, unlike red cells. There is also evidence of variation in usage among countries--use in England and Wales may be proportionately less per patient than current levels of usage in other European countries and the United States. Plasma for transfusion is most often used where there is abnormal coagulation screening tests, either therapeutically in the face of bleeding, or prophylactically in non-bleeding subjects prior to invasive procedures or surgery. Little evidence exists to inform best therapeutic plasma transfusion practice. Most studies have described plasma use in a prophylactic setting, in which laboratory abnormalities of coagulation tests are considered a predictive risk factor for bleeding prior to invasive procedures. The strongest randomised controlled trial (RCT) evidence indicates that prophylactic plasma for transfusion is not effective across a range of different clinical settings and this is supported by data from non-randomised studies in patients with mild to moderate abnormalities in coagulation tests. There are also uncertainties whether plasma consistently improves the laboratory results for patients with mild to moderate abnormalities in coagulation tests. There is a need to undertake new trials evaluating the efficacy and adverse effects of plasma, both in bleeding and non-bleeding patients, to understand whether the "presumed" benefits outweigh the "real risks". In addition, new haemostatic tests should be validated which better define risk of bleeding.

  11. How to synthesize evidence for imaging guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Matowe, L. E-mail: l.matowe@hsc.kuniv.edu.kw; Gilbert, F. J

    2004-01-01

    AIM: To provide guidance on how to gather and evaluate evidence from the literature on the efficacy of imaging, using as an example the assessment of the role of magnetic resonance imaging (MRI) in the diagnosis of osteomyelitis. This method was adopted for evaluating evidence for the musculoskeletal section of the 5th edition of the Royal College of Radiologists' (RCR) guidelines. MATERIALS AND METHODS: A systematic review of the literature published between 1966 and July 2001 was carried out. Eligible articles described studies in patients with suspected osteomyelitis and who were diagnosed using MRI. Search strategies were developed to identify relevant imaging studies. Studies included in the systematic review were selected using predefined criteria. The sensitivity, specificity, accuracy and likelihood ratios for MRI reported in the studies were used to evaluate the value of the procedure in osteomyelitis. Where the above were not reported, they were calculated by the reviewers. RESULTS: The average sensitivity of MRI in osteomyelitis was 91% (range 76-100%), the average specificity was 82% (range 65-96%), average accuracy was 88% (range 71-97%), and the average positive likelihood ratio was 7.8 (range 2.3-21.1). Four studies evaluated the use of MRI in the diagnosis of osteomyelitis in the diabetic foot, two in osteomyelitis of the lower extremities, while four each evaluated the use of MRI in vertebral osteomyelitis, in the diagnosis of any form of osteomyelitis, osteomyelitis in spinal cord-injured patients and in cranial osteomyelitis. CONCLUSION: Systematic reviews of literature can be used to obtain evidence on the value of imaging procedures. The quality of the studies included in the review should always be considered when selecting studies to limit bias. In our example, MRI appears sensitive, specific and accurate in the diagnosis of osteomyelitis at different sites.

  12. Negative evidence in L2 acquisition

    Directory of Open Access Journals (Sweden)

    Anne Dahl

    2005-02-01

    Full Text Available This article deals with the L2 acquisition of differences between Norwegian and English passives, and presents data to show that the acquisition of these differences by Norwegian L2 acquirers of English cannot be fully explained by positive evidence, cues, conservativism or economy. Rather, it is argued, it is natural to consider whether indirect negative evidence may facilitate acquisition by inferencing. The structures in focus are impersonal passive constructions with postverbal NPs and passive constructions with intransitive verbs. These sentences are ungrammatical in English. Chomsky (1981 proposes that this is a result of passive morphology absorbing objective case in English. There is no such case to be assigned to the postverbal NP in impersonal passives. In passive constructions with intransitive verbs, the verb does not assign objective case, so that there is no case for the passive morphology to absorb. Thus, impersonal passives have to be changed into personal passives, where the NP receives nominative case, and the objective case is free to go to the passive morphology. Intransitive verbs, however, cannot be used in the passive voice at all. Both the structures discussed in this article, i.e. are grammatical in Norwegian. However, the options available in English, viz. personal passives and active sentences, are equally possible. Åfarli (1992 therefore proposes that Norwegian has optional case absorption (passive morphology optionally absorbs case. On the basis on such observations, we may propose a parameter with the settings [+case absorption] for English, and [-case absorption], signifying optional case absorption, for Norwegian. This means that none of the structures that are grammatical in English can function as positive evidence for the [+case absorption] setting, since they are also grammatical in optional case absorption languages. The question is how this parameter is set.

  13. Health systems integration: state of the evidence

    Directory of Open Access Journals (Sweden)

    Gail D. Armitage

    2009-06-01

    Full Text Available Introduction: Integrated health systems are considered a solution to the challenge of maintaining the accessibility and integrity of healthcare in numerous jurisdictions worldwide. However, decision makers in a Canadian health region indicated they were challenged to find evidence-based information to assist with the planning and implementation of integrated healthcare systems. Methods: A systematic literature review of peer-reviewed literature from health sciences and business databases, and targeted grey literature sources. Results: Despite the large number of articles discussing integration, significant gaps in the research literature exist. There was a lack of high quality, empirical studies providing evidence on how health systems can improve service delivery and population health. No universal definition or concept of integration was found and multiple integration models from both the healthcare and business literature were proposed in the literature. The review also revealed a lack of standardized, validated tools that have been systematically used to evaluate integration outcomes. This makes measuring and comparing the impact of integration on system, provider and patient level challenging. Discussion and conclusion: Healthcare is likely too complex for a one-size-fits-all integration solution. It is important for decision makers and planners to choose a set of complementary models, structures and processes to create an integrated health system that fits the needs of the population across the continuum of care. However, in order to have evidence available, decision makers and planners should include evaluation for accountability purposes and to ensure a better understanding of the effectiveness and impact of health systems integration.

  14. Ethical reflections on Evidence Based Medicine

    Directory of Open Access Journals (Sweden)

    S. Corrao

    2013-05-01

    Full Text Available BACKGROUND According to Potter’s point of view, medical ethics is the science of survival, a bridge between humanistic and scientific culture. The working out of judgements on right or wrong referred to the human being are studied by this science. Methodological quality is fundamental in clinical research, and several technical issues are of paramount importance in trying to answer to the final question “what is the true, the right thing?”. We know they are essential aspects as in medical ethics as in evidence based practice. AIM OF THE STUDY The aim of this paper is to talk about relationships and implications between ethical issues and Evidence Based Medicine (EBM. DISCUSSION EBM represents a new paradigm that introduces new concepts to guide medical-decision making and health-care planning. Its principles are deeply rooted in clinical research methodology since information are derived from sound studies of strong quality. Health-care professionals have to deal with methodological concepts for critical appraisal of literature and implementation of evidences in clinical practice and healthcare planning. The central role of EBM in medical ethics is obvious, but a risk could be possible. The shift from Hippocratic point of view to community-centred one could lose sight of the centrality of the patient. CONCLUSION Both EBM principles and the needs to adequately response to economic restrictions urge a balance between individual and community ethics. All this has to represent an opportunity to place the patient at the centre of medical action considering at the same time community ethics as systemic aim, but without forgetting the risk that economic restrictions push towards veterinary ethics where herd is central and individual needs do not exist.

  15. Death investigation after the destruction of evidence.

    Science.gov (United States)

    Danto, B L; Streed, T

    1994-05-01

    Unavailable in the literature is any reference to an investigation of death after evidence has been destroyed. In this presentation two firearms and the bullet were melted after the death was certified as a suicide. A team of investigators conducted a psychological autopsy as well as shot patterns to determine the distance from the gun muzzle to the head to determine whether or not the wound was a contact type. The resolution of the case is discussed and the factor of local politics and case prominence in the media is reviewed.

  16. Astrophysical Black Holes: Evidence of a Horizon?

    Science.gov (United States)

    Colpi, Monica

    In this Lecture Note we first follow a short account of the history of the black hole hypothesis. We then review on the current status of the search for astrophysical black holes with particular attention to the black holes of stellar origin. Later, we highlight a series of observations that reveal the albeit indirect presence of supermassive black holes in galactic nuclei, with mention to forthcoming experiments aimed at testing directly the black hole hypothesis. We further focus on evidences of a black hole event horizon in cosmic sources.

  17. Palaeoclimatology: evidence for hot early oceans?

    Science.gov (United States)

    Shields, Graham A; Kasting, James F

    2007-05-01

    The oxygen isotopes in sedimentary cherts (siliceous sediments) have been used to argue that the Precambrian oceans were hot--with temperatures of up to 70 degrees C at 3.3 Gyr before present. Robert and Chaussidon measure silicon isotopes in cherts and arrive at a similar conclusion. We suggest here that both isotope trends may be caused by variations in seawater isotope composition, rather than in ocean temperatures. If so, then the climate of the early Earth may have been temperate, as it is today, and therefore more consistent with evidence for Precambrian glaciations and with constraints inferred from biological evolution.

  18. Evidences for magicity in superdeformed shapes

    Indian Academy of Sciences (India)

    Suresh Kumar

    2014-05-01

    Many empirical evidences that point to the existence of preferred magic nucleon numbers for superdeformed (SD) shapes are presented in this paper. We use a simple premise based on the 4-parameter formula fitted using observed -rays of SD bands. In particular, plots of -ray energy ratios, nuclear softness parameter values and the number of SD bands for given and are used to pinpoint the magicity (, numbers) that are most favoured as the SD magic numbers. This analysis also leads to several new predictions on the occurrence of SD bands specially in neutron-rich nuclei.

  19. Evidence for shape coexistence in $^{98}$Mo

    CERN Document Server

    Thomas, T; Werner, V; Ahn, T; Cooper, N; Duckwitz, H; Hinton, M; Ilie, G; Jolie, J; Petkov, P; Radeck, D

    2013-01-01

    A $\\gamma\\gamma$ angular correlation experiment has been performed to investigate the low-energy states of the nucleus $^{98}$Mo. The new data, including spin assignments, multipole mixing ratios and lifetimes reveal evidence for shape coexistence and mixing in $^{98}$Mo, arising from a proton intruder configuration. This result is reproduced by a theoretical calculation within the proton-neutron interacting boson model with configuration mixing, based on microscopic energy density functional theory. The microscopic calculation indicates the importance of the proton particle-hole excitation across the Z=40 sub-shell closure and the subsequent mixing between spherical vibrational and the $\\gamma$-soft equilibrium shapes in $^{98}$Mo.

  20. Evidence for further charmonium vector resonances

    Institute of Scientific and Technical Information of China (English)

    Eef van Beveren; George Rupp

    2011-01-01

    We discuss the shape of threshold signals in production cross sections of the reaction ee → DD, at the opening of the DD and ΛΛ channels. Furthermore, evidence for the ψ(3D), ψ(5S), ψ(4D), ψ(6S), ψ(5D), ψ(7S), ψ(6D), and ψ(8S) new charmonium vector resonances is presented, on the basis of data recently published by the BABAR Collaboration. Central masses and resonance widths are estimated. Confirmation of these resonances would be a huge step in lifting the precision level of hadron spectroscopy towards that of atomic spectroscopy, with far-reaching consequences for theory.

  1. Recent Evidence Regarding Triclosan and Cancer Risk

    Directory of Open Access Journals (Sweden)

    Michael T. Dinwiddie

    2014-02-01

    Full Text Available Triclosan is a broad-spectrum antibacterial commonly used in cosmetics, dentifrices, and other consumer products. The compound’s widespread use in consumer products and its detection in breast milk, urine, and serum have raised concerns regarding its potential association with various human health outcomes.  Recent evidence suggests that triclosan may play a role in cancer development, perhaps through its estrogenicity or ability to inhibit fatty acid synthesis. Our aims here are to review studies of human exposure levels, to evaluate the results of studies examining the effects of triclosan on cancer development, and to suggest possible directions for future research.

  2. Evidence for weight effects in Russian

    DEFF Research Database (Denmark)

    Kizach, Johannes

    2012-01-01

    It is well-known that factors such as weight, pronominality, animacy and newness influence word order in several languages, but whereas newness repeatedly has been argued to be a relevant factor for Russian, little or no attention has been paid to weight. In this paper, which is based on evidence...... from corpus data, weight is demonstrated to have a very significant influence on word order in Russian. Specifically, four constructions are tested: Postverbal PPs, the double object construction, adversity impersonals and the order of S, V and O. In all cases the same pattern emerges: The heavier...

  3. Direct Evidence on Learning by Exporting

    DEFF Research Database (Denmark)

    Grimpe, Christoph; Belderbos, Rene

    2014-01-01

    We examine first direct evidence on the occurrence of learning by exporting, using unique survey data for German innovating firms on the role of (foreign) customers and competitors as sources of ideas and impetus for innovation. Export intensive firms frequently benefit simultaneously from domestic...... learning and export learning – an issue that has been ignored in prior studies. Learning from foreign customers is more prevalent than learning from foreign competitors. Firms’ underlying innovation strategy appears as an important moderator of the propensity to learn and of the relationship between...

  4. Evidence for further charmonium vector resonances

    Institute of Scientific and Technical Information of China (English)

    Eel van Bevere; George Rupp

    2011-01-01

    We discuss the shape of threshold signals in production cross sections of the reaction e+e- → D* Dˉ*, at the opening of the Ds* Dˉs* and Λc+ Λ+c channels. Furthermore, evidence for the ψ(3D), ψ(5S), ψ(4D), ψ(6S), ψ(5D), ψ(7S), ψ(6D), and ψ(8S) new charmon

  5. Utility-driven evidence for healthy cities

    DEFF Research Database (Denmark)

    de Leeuw, Evelyne; Skovgaard, Thomas

    2005-01-01

    performances within the realm of Healthy Cities. A main point of reference is the European Healthy Cities Project (E-HCP). Building on the information gathered through documentary research on the topic, it is concluded that there is fair evidence that Healthy Cities works. However, the future holds great......The question whether the WHO Healthy Cities project 'works' has been asked ever since a number of novel ideas and actions related to community health, health promotion and healthy public policy in the mid 1980s came together in the Healthy Cities Movement initiated by the World Health Organization...

  6. Primordial Features as Evidence for Inflation

    CERN Document Server

    Chen, Xingang

    2011-01-01

    In the primordial universe, particles with mass much larger than the mass-scale of the event-horizon (such as the Hubble parameter in inflation) exist ubiquitously, and can be excited from time to time and oscillate quickly around its minimum. These excitations can induce specific patterns in density perturbations, which record the time dependence of the scale factor of the primordial universe, thus provide direct evidence for the inflationary epoch or its alternatives. Such effects are conventionally integrated out in theoretical and data analyses, but can be accessible for experiments targeting on density perturbations with high multiples.

  7. [Evidence-based clinical practice. Part II--Searching evidence databases].

    Science.gov (United States)

    Bernardo, Wanderley Marques; Nobre, Moacyr Roberto Cuce; Jatene, Fábio Biscegli

    2004-01-01

    The inadequacy of most of traditional sources for medical information, like textbook and review article, do not sustained the clinical decision based on the best evidence current available, exposing the patient to a unnecessary risk. Although not integrated around clinical problem areas in the convenient way of textbooks, current best evidence from specific studies of clinical problems can be found in an increasing number of Internet and electronic databases. The sources that have already undergone rigorous critical appraisal are classified as secondary information sources, others that provide access to original article or abstract, as primary information source, where the quality assessment of the article rely on the clinician oneself . The most useful primary information source are SciELO, the online collection of Brazilian scientific journals, and Medline, the most comprehensive database of the USA National Library of Medicine, where the search may start with use of keywords, that were obtained at the structured answer construction (P.I.C.O.), with the addition of boolean operators "AND", "OR", "NOT". Between the secondary information sources, some of them provide critically appraised articles, like ACP Journal Club, Evidence Based Medicine and InfoPOEMs, others provide evidences organized as online texts, such as "Clinical Evidence" and "UpToDate", and finally, Cochrane Library are composed by systematic reviews of randomized controlled trials. To get studies that could answer the clinical question is part of a mindful practice, that is, becoming quicker and quicker and dynamic with the use of PDAs, Palmtops and Notebooks.

  8. The Big Five default brain: functional evidence.

    Science.gov (United States)

    Sampaio, Adriana; Soares, José Miguel; Coutinho, Joana; Sousa, Nuno; Gonçalves, Óscar F

    2014-11-01

    Recent neuroimaging studies have provided evidence that different dimensions of human personality may be associated with specific structural neuroanatomic correlates. Identifying brain correlates of a situation-independent personality structure would require evidence of a stable default mode of brain functioning. In this study, we investigated the correlates of the Big Five personality dimensions (Extraversion, Neuroticism, Openness/Intellect, Agreeableness, and Conscientiousness) and the default mode network (DMN). Forty-nine healthy adults completed the NEO-Five Factor. The results showed that the Extraversion (E) and Agreeableness (A) were positively correlated with activity in the midline core of the DMN, whereas Neuroticism (N), Openness (O), and Conscientiousness (C) were correlated with the parietal cortex system. Activity of the anterior cingulate cortex was positively associated with A and negatively with C. Regions of the parietal lobe were differentially associated with each personality dimension. The present study not only confirms previous functional correlates regarding the Big Five personality dimensions, but it also expands our knowledge showing the association between different personality dimensions and specific patterns of brain activation at rest.

  9. Evidence-based treatments for cluster headache

    Directory of Open Access Journals (Sweden)

    Gooriah R

    2015-11-01

    Full Text Available Rubesh Gooriah, Alina Buture, Fayyaz Ahmed Department of Neurology, Hull Royal Infirmary, Kingston upon Hull, UK Abstract: Cluster headache (CH, one of the most painful syndromes known to man, is managed with acute and preventive medications. The brief duration and severity of the attacks command the use of rapid-acting pain relievers. Inhalation of oxygen and subcutaneous sumatriptan are the two most effective acute therapeutic options for sufferers of CH. Several preventive medications are available, the most effective of which is verapamil. However, most of these agents are not backed by strong clinical evidence. In some patients, these options can be ineffective, especially in those who develop chronic CH. Surgical procedures for the chronic refractory form of the disorder should then be contemplated, the most promising of which is hypothalamic deep brain stimulation. We hereby review the pathogenesis of CH and the evidence behind the treatment options for this debilitating condition. Keywords: cluster headache, pathogenesis, vasoactive intestinal peptide, suprachiasmatic nucleus

  10. Nutrition and Dementia: Evidence for Preventive Approaches?

    Science.gov (United States)

    Canevelli, Marco; Lucchini, Flaminia; Quarata, Federica; Bruno, Giuseppe; Cesari, Matteo

    2016-01-01

    In recent years, the possibility of favorably influencing the cognitive trajectory through promotion of lifestyle modifications has been increasingly investigated. In particular, the relationship between nutritional habits and cognitive health has attracted special attention. The present review is designed to retrieve and discuss recent evidence (published over the last 3 years) coming from randomized controlled trials (RCTs) investigating the efficacy of nutritional interventions aimed at improving cognitive functioning and/or preventing cognitive decline in non-demented older individuals. A systematic review of literature was conducted, leading to the identification of 11 studies of interest. Overall, most of the nutritional interventions tested by the selected RCTs were found to produce statistically significant cognitive benefits (defined as improved neuropsychological test scores). Nevertheless, the clinical meaningfulness of such findings was not adequately discussed and appears controversial. In parallel, only 2 studies investigated between-group differences concerning incident dementia and mild cognitive impairment cases, reporting conflicting results. Results of the present review suggest that several dietary patterns and nutritional components may constitute promising strategies in postponing, slowing, and preventing cognitive decline. However, supporting evidence is overall weak and further studies are needed. PMID:26959055

  11. Can lip prints provide biologic evidence?

    Science.gov (United States)

    Sharma, Preeti; Sharma, Neeraj; Wadhwan, Vijay; Aggarwal, Pooja

    2016-01-01

    Background: Lip prints are unique and can be used in personal identification. Very few studies are available which establish them as biological evidence in the court of law. Thus, the objective of this study was to attempt to isolate DNA and obtain full short tandem repeat (STR) loci of the individual from the lip prints on different surfaces. Materials and Methods: Twelve lip prints were procured on different surfaces such as tissue paper, cotton cloth, ceramic tile, and glass surface. Latent lip prints were developed using fingerprint black powder. Lipstick-coated lip prints were also collected on the same supporting items. DNA was isolated, quantified, and amplified using Identifiler™ kit to type 15 STR loci. Results: Ample quantity of DNA was extracted from all the lip print impressions and 15 loci were successfully located in seven samples. Fourteen loci were successfully typed in 3 lip impressions while 13 loci were typed in 2 samples. Conclusion: This study emphasizes the relevance of lip prints at the scene of crime. Extraction of DNA followed by typing of STR loci establishes the lip prints as biological evidence too. Tissue papers, napkins, cups, and glasses may have imprints of the suspect's lips. Thus, the full genetic profile is extremely useful for the forensic team. PMID:28123277

  12. Can lip prints provide biologic evidence?

    Directory of Open Access Journals (Sweden)

    Preeti Sharma

    2016-01-01

    Full Text Available Background: Lip prints are unique and can be used in personal identification. Very few studies are available which establish them as biological evidence in the court of law. Thus, the objective of this study was to attempt to isolate DNA and obtain full short tandem repeat (STR loci of the individual from the lip prints on different surfaces. Materials and Methods: Twelve lip prints were procured on different surfaces such as tissue paper, cotton cloth, ceramic tile, and glass surface. Latent lip prints were developed using fingerprint black powder. Lipstick-coated lip prints were also collected on the same supporting items. DNA was isolated, quantified, and amplified using IdentifilerTM kit to type 15 STR loci. Results: Ample quantity of DNA was extracted from all the lip print impressions and 15 loci were successfully located in seven samples. Fourteen loci were successfully typed in 3 lip impressions while 13 loci were typed in 2 samples. Conclusion: This study emphasizes the relevance of lip prints at the scene of crime. Extraction of DNA followed by typing of STR loci establishes the lip prints as biological evidence too. Tissue papers, napkins, cups, and glasses may have imprints of the suspect's lips. Thus, the full genetic profile is extremely useful for the forensic team.

  13. The Solar Photosphere: Evidence for Condensed Matter

    Directory of Open Access Journals (Sweden)

    Robitaille P. M.

    2006-04-01

    Full Text Available The stellar equations of state treat the Sun much like an ideal gas, wherein the photosphere is viewed as a sparse gaseous plasma. The temperatures inferred in the solar interior give some credence to these models, especially since it is counterintuitive that an object with internal temperatures in excess of 1 MK could be existing in the liquid state. Nonetheless, extreme temperatures, by themselves, are insufficient evidence for the states of matter. The presence of magnetic fields and gravity also impact the expected phase. In the end, it is the physical expression of a state that is required in establishing the proper phase of an object. The photosphere does not lend itself easily to treatment as a gaseous plasma. The physical evidence can be more simply reconciled with a solar body and a photosphere in the condensed state. A discussion of each physical feature follows: (1 the thermal spectrum, (2 limb darkening, (3 solar collapse, (4 the solar density, (5 seismic activity, (6 mass displacement, (7 the chromosphere and critical opalescence, (8 shape, (9 surface activity, (10 photospheric/coronal flows, (11 photospheric imaging, (12 the solar dynamo, and (13 the presence of Sun spots. The explanation of these findings by the gaseous models often requires an improbable combination of events, such as found in the stellar opacity problem. In sharp contrast, each can be explained with simplicity by the condensed state. This work is an invitation to reconsider the phase of the Sun.

  14. How to find the best evidence.

    Science.gov (United States)

    Chatburn, Robert L

    2009-10-01

    The Internet has made finding evidence for clinical practice fairly easy. Many different types of databases that can be searched for relevant key terms are available for free or for subscription. Bibliographic or library databases contain books, book chapters, reports, citations, abstracts, and either the full text of the articles indexed or links to the full text. Citation databases are specially designed so that you can track the progress of an idea or research topic by searching the published works that cite a particular author or article. Synthesized databases are pre-filtered records for particular topics. They are usually subscription-based, with relatively large fees (but you can get free access in libraries). This type of database may provide the "best" evidence without extensive searches of standard bibliographic databases. Portals are Web pages that act as a starting point for using the Web or Web-based services and links to books, journals, patient-education resources, and images. Many medical journals, including Respiratory Care, are now available online. Finally, even generalized search engines such as Google, Yahoo, Ask, and Dogpile can provide a wealth of information on medical topics.

  15. Infection and childhood leukemia: review of evidence

    Directory of Open Access Journals (Sweden)

    Raquel da Rocha Paiva Maia

    2013-12-01

    Full Text Available OBJECTIVE : To analyze studies that evaluated the role of infections as well as indirect measures of exposure to infection in the risk of childhood leukemia, particularly acute lymphoblastic leukemia. METHODS : A search in Medline, Lilacs, and SciELO scientific publication databases initially using the descriptors “childhood leukemia” and “infection” and later searching for the words “childhood leukemia” and “maternal infection or disease” or “breastfeeding” or “daycare attendance” or “vaccination” resulted in 62 publications that met the following inclusion criteria: subject aged ≤ 15 years; specific analysis of cases diagnosed with acute lymphoblastic leukemia or total leukemia; exposure assessment of mothers’ or infants’ to infections (or proxy of infection, and risk of leukemia. RESULTS : Overall, 23 studies that assessed infections in children support the hypothesis that occurrence of infection during early childhood reduces the risk of leukemia, but there are disagreements within and between studies. The evaluation of exposure to infection by indirect measures showed evidence of reduced risk of leukemia associated mainly with daycare attendance. More than 50.0% of the 16 studies that assessed maternal exposure to infection observed increased risk of leukemia associated with episodes of influenza, pneumonia, chickenpox, herpes zoster, lower genital tract infection, skin disease, sexually transmitted diseases, Epstein-Barr virus, and Helicobacter pylori . CONCLUSIONS : Although no specific infectious agent has been identified, scientific evidence suggests that exposure to infections has some effect on childhood leukemia etiology.

  16. Genomic evidence for adaptation by gene duplication.

    Science.gov (United States)

    Qian, Wenfeng; Zhang, Jianzhi

    2014-08-01

    Gene duplication is widely believed to facilitate adaptation, but unambiguous evidence for this hypothesis has been found in only a small number of cases. Although gene duplication may increase the fitness of the involved organisms by doubling gene dosage or neofunctionalization, it may also result in a simple division of ancestral functions into daughter genes, which need not promote adaptation. Hence, the general validity of the adaptation by gene duplication hypothesis remains uncertain. Indeed, a genome-scale experiment found similar fitness effects of deleting pairs of duplicate genes and deleting individual singleton genes from the yeast genome, leading to the conclusion that duplication rarely results in adaptation. Here we contend that the above comparison is unfair because of a known duplication bias among genes with different fitness contributions. To rectify this problem, we compare homologous genes from the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. We discover that simultaneously deleting a duplicate gene pair in S. cerevisiae reduces fitness significantly more than deleting their singleton counterpart in S. pombe, revealing post-duplication adaptation. The duplicates-singleton difference in fitness effect is not attributable to a potential increase in gene dose after duplication, suggesting that the adaptation is owing to neofunctionalization, which we find to be explicable by acquisitions of binary protein-protein interactions rather than gene expression changes. These results provide genomic evidence for the role of gene duplication in organismal adaptation and are important for understanding the genetic mechanisms of evolutionary innovation.

  17. Forensic surface metrology: tool mark evidence.

    Science.gov (United States)

    Gambino, Carol; McLaughlin, Patrick; Kuo, Loretta; Kammerman, Frani; Shenkin, Peter; Diaczuk, Peter; Petraco, Nicholas; Hamby, James; Petraco, Nicholas D K

    2011-01-01

    Over the last several decades, forensic examiners of impression evidence have come under scrutiny in the courtroom due to analysis methods that rely heavily on subjective morphological comparisons. Currently, there is no universally accepted system that generates numerical data to independently corroborate visual comparisons. Our research attempts to develop such a system for tool mark evidence, proposing a methodology that objectively evaluates the association of striated tool marks with the tools that generated them. In our study, 58 primer shear marks on 9 mm cartridge cases, fired from four Glock model 19 pistols, were collected using high-resolution white light confocal microscopy. The resulting three-dimensional surface topographies were filtered to extract all "waviness surfaces"-the essential "line" information that firearm and tool mark examiners view under a microscope. Extracted waviness profiles were processed with principal component analysis (PCA) for dimension reduction. Support vector machines (SVM) were used to make the profile-gun associations, and conformal prediction theory (CPT) for establishing confidence levels. At the 95% confidence level, CPT coupled with PCA-SVM yielded an empirical error rate of 3.5%. Complementary, bootstrap-based computations for estimated error rates were 0%, indicating that the error rate for the algorithmic procedure is likely to remain low on larger data sets. Finally, suggestions are made for practical courtroom application of CPT for assigning levels of confidence to SVM identifications of tool marks recorded with confocal microscopy.

  18. Barriers to Research and Evidence (Editorial

    Directory of Open Access Journals (Sweden)

    Alison Brettle

    2013-06-01

    Full Text Available I often find attending conferences or workshops a source of reflection or inspiration for editorials, and today I attended an event that proved to be no exception. The HEALER network is a UK grouping of professionals interested in health library research. It brings together those working in health information at an academic, practitioner or strategic capacity as well as those working in higher education, research and the NHS. (http://www.libraryservices.nhs.uk/healer/minutes.htmlThere were a number of interesting presentations, but one (and the subsequent interactive discussions left me with some worrying thoughts. Hannah Spring (2013 presented some of the findings from her PhD that found when health librarians were asked about their barriers to research they reported that they didn't know what research questions to ask! Alternatively if they had research questions they didn't think to engage with the literature or believed that there was no evidence to answer them! If we really don't have any research questions, and we really don't think to look at the literature or there really is no evidence, this is worrying indeed for the future of EBLIP. It's also a situation I don't recognize from being involved in the EBLIP journal and was left wondering whether it was the health librarians perceptions of “research” and “evidence” that was the issue; questions which are being examined in the LIRG Scan which was described in another presentation. The scan is a review of the evidence on: What practitioners understand by research; what kind of research is relevant to LIS practitioners? How do they use research and what are the barriers and facilitators to using research in practice? (https://sites.google.com/site/lirgweb/home/awards/lirg-scan-award The results will be used to help inform the Chartered Institute for Library and Information Professionals’ policy on research.The barrier which I’m much more familiar in terms of engaging with

  19. Brain and language: evidence for neural multifunctionality.

    Science.gov (United States)

    Cahana-Amitay, Dalia; Albert, Martin L

    2014-01-01

    This review paper presents converging evidence from studies of brain damage and longitudinal studies of language in aging which supports the following thesis: the neural basis of language can best be understood by the concept of neural multifunctionality. In this paper the term "neural multifunctionality" refers to incorporation of nonlinguistic functions into language models of the intact brain, reflecting a multifunctional perspective whereby a constant and dynamic interaction exists among neural networks subserving cognitive, affective, and praxic functions with neural networks specialized for lexical retrieval, sentence comprehension, and discourse processing, giving rise to language as we know it. By way of example, we consider effects of executive system functions on aspects of semantic processing among persons with and without aphasia, as well as the interaction of executive and language functions among older adults. We conclude by indicating how this multifunctional view of brain-language relations extends to the realm of language recovery from aphasia, where evidence of the influence of nonlinguistic factors on the reshaping of neural circuitry for aphasia rehabilitation is clearly emerging.

  20. Evidence-Based Interactive Management of Change

    Directory of Open Access Journals (Sweden)

    Albert Fleischmann

    2011-06-01

    Full Text Available Evidence-based interactive management of change means hands-on experience of modified work processes, given evidence of change. For this kind of pro-active organizational development support we use an organisational process memory and a communication-based representation technique for role-specific and task-oriented process execution. Both are effective means for organizations becoming agile through interactively modelling the business at the process level and re-constructing or re-arranging process representations according to various needs. The tool allows experiencing role-specific workflows, as the communication-based refinement of work models allows for executable process specifications. When presenting the interactive processes to individuals involved in the business processes, changes can be explored interactively in a context-sensitive way before re-implementing business processes and information systems. The tool is based on a service-oriented architecture and a flexible representation scheme comprising the exchange of message between actors, business objects and actors (roles. The interactive execution of workflows does not only enable the individual reorganization of work but also changes at the level of the entire organization due to the represented interactions.

  1. Toward an evidence-based toxicology.

    Science.gov (United States)

    Hoffmann, S; Hartung, T

    2006-09-01

    The increasing demands on toxicology of large-scale risk assessment programmes for chemicals and emerging or expanding areas of chemical use suggest it is timely to review the toxicological toolbox. Like in clinical medicine, where an evidence-based medicine (EBM) is critically reviewing traditional approaches, toxicology has the opportunity to reshape and enlarge its methodology and approaches on the basis of compounded scientific knowledge. Such revision would have to be based on structured reviews of current practice, ie, assessment of test performance characteristics, mechanistic understanding, extended quality assurance, formal validation and the use of integrated testing strategies. This form of revision could optimize the balance between safety, costs and animal welfare, explicitly stating and, where possible, quantifying uncertainties. After a self-critical reassessment of current practices and evaluation of the thus generated information, such an evidence-based toxicology (EBT) promises to make better use of resources and to increase the quality of results, facilitating their interpretation. It shall open up hazard and also risk assessments to new technologies, flexibly accommodating current and future mechanistic understanding. An EBT will be better prepared to answer the continuously growing safety demands of modern societies.

  2. [Evidence that suggest the reality of reincarnation].

    Science.gov (United States)

    Bonilla, Ernesto

    2015-06-01

    Worldwide, children can be found who reported that they have memories of a previous life. More than 2,500 cases have been studied and their specifications have been published and preserved in the archives of the Division of Perceptual Studies at the University of Virginia (United States). Many of those children come from countries where the majority of the inhabitants believe in reincarnation, but others come from countries with different cultures and religions that reject it. In many cases, the revelations of the children have been verified and have corresponded to a particular individual, already dead. A good number of these children have marks and birth defects corresponding to wounds on the body of his previous personality. Many have behaviors related to their claims to their former life: phobias, philias, and attachments. Others seem to recognize people and places of his supposed previous life, and some of their assertions have been made under controlled conditions. The hypothesis of reincarnation is controversial. We can never say that it does not occur, or will obtain conclusive evidence that it happens. The cases that have been described so far, isolated or combined, do not provide irrefutable proof of reincarnation, but they supply evidence that suggest its reality.

  3. Nutrition and Dementia: Evidence for Preventive Approaches?

    Directory of Open Access Journals (Sweden)

    Marco Canevelli

    2016-03-01

    Full Text Available In recent years, the possibility of favorably influencing the cognitive trajectory through promotion of lifestyle modifications has been increasingly investigated. In particular, the relationship between nutritional habits and cognitive health has attracted special attention. The present review is designed to retrieve and discuss recent evidence (published over the last 3 years coming from randomized controlled trials (RCTs investigating the efficacy of nutritional interventions aimed at improving cognitive functioning and/or preventing cognitive decline in non-demented older individuals. A systematic review of literature was conducted, leading to the identification of 11 studies of interest. Overall, most of the nutritional interventions tested by the selected RCTs were found to produce statistically significant cognitive benefits (defined as improved neuropsychological test scores. Nevertheless, the clinical meaningfulness of such findings was not adequately discussed and appears controversial. In parallel, only 2 studies investigated between-group differences concerning incident dementia and mild cognitive impairment cases, reporting conflicting results. Results of the present review suggest that several dietary patterns and nutritional components may constitute promising strategies in postponing, slowing, and preventing cognitive decline. However, supporting evidence is overall weak and further studies are needed.

  4. Cesarean delivery technique: evidence or tradition? A review of the evidence-based cesarean delivery.

    Science.gov (United States)

    Encarnacion, Betsy; Zlatnik, Marya G

    2012-08-01

    Cesarean delivery is the most common surgical procedure performed in the United States, yet the techniques used during this procedure often vary significantly among providers. The purpose of this review was to evaluate and outline current evidence behind the cesarean delivery technique. A search of the PubMed database was conducted using the terms cesarean section and cesarean delivery and the technique of interest, for example, cesarean section prophylactic antibiotics. Few aspects of the cesarean delivery were found to have high-quality consistent evidence to support use of a particular technique. Because many aspects of the procedure are based on limited or no data, more studies on specific cesarean delivery techniques are clearly needed. Providers should be aware of which components of the cesarean delivery are evidence-based versus not when performing this procedure.

  5. Adopting Hadith Verification Techniques in to Digital Evidence Authentication

    Directory of Open Access Journals (Sweden)

    Yunus Yusoff

    2010-01-01

    Full Text Available Problem statement: The needs of computer forensics investigators have been directly influenced by the increasing number of crimes performed using computers. It is the responsibility of the investigator to ascertain the authenticity of the collected digital evidence. Without proper classification of digital evidence, the computer forensics investigator may ended up investigating using untrusted digital evidence and ultimately cannot be use to implicate the suspected criminal. Approach: The historical methods of verifying the authenticity of a hadith were studied. The similarities between hadith authentication and digital evidence authentication were identified. Based on the similarities of the identified processes, a new method of authenticating digital evidence were proposed, together with the trust calculation algorithm and evidence classification. Results: The new investigation processes and an algorithm to calculate the trust value of a given digital evidence was proposed. Furthermore, a simple classification of evidence, based on the calculated trust values was also proposed. Conclusion/Recommendations: We had successfully extracted the methods to authenticate hadith and mapped it into the digital evidence authentication processes. The trust values of digital evidence were able to be calculated and the evidence can be further classified based on the different level of trust values. The ability to classify evidence based on trust levels can offer great assistance to the computer forensics investigator to plan their works and focus on the evidence that would give them a better chance of catching the criminals.

  6. How to understand and conduct evidence-based medicine

    Science.gov (United States)

    2016-01-01

    Evidence-based medicine (EBM) is the conscientious, explicit, and judicious use of current best evidence in making decisions regarding the care of individual patients. This concept has gained popularity recently, and its applications have been steadily expanding. Nowadays, the term "evidence-based" is used in numerous situations and conditions, such as evidence-based medicine, evidence-based practice, evidence-based health care, evidence-based social work, evidence-based policy, and evidence-based education. However, many anesthesiologists and their colleagues have not previously been accustomed to utilizing EBM, and they have experienced difficulty in understanding and applying the techniques of EBM to their practice. In this article, the author discusses the brief history, definition, methods, and limitations of EBM. As EBM also involves making use of the best available information to answer questions in clinical practice, the author emphasizes the process of performing evidence-based medicine: generate the clinical question, find the best evidence, perform critical appraisal, apply the evidence, and then evaluate. Levels of evidence and strength of recommendation were also explained. The author expects that this article may be of assistance to readers in understanding, conducting, and evaluating EBM.

  7. Evidence Based Practice Outside the Box (Editorial

    Directory of Open Access Journals (Sweden)

    Lindsay Glynn

    2008-09-01

    Full Text Available I love food. I love cooking, baking, testing, and eating. I read about food preparation, food facts, and food service. Over the years I’ve developed my fair share of knowledge about cooking and I’m a decent cook, but I’m no chef. I guess I’m what you’d call a “foodie”. However, I have the good fortune to have a friend who is a chef and owns one of the best, and certainly the most innovative, restaurants in town. During this summer I hosted a cooking class in my home for my family with my chef friend as instructor. The Tex-Mex barbecue theme was a big hit (you can contact me for recipes, if you like, but much more fascinating was the explanation of the science behind the cooking. It turns out that there is a term for this: molecular gastronomy. Another term, and hence the genesis of my “Eureka!” moment of the summer, is evidence based cooking. Good cooking is not just following a recipe (not all of which are evidence based but at its best is the culmination of heaps of tested information regarding why and how chemical and environmental factors work together to result in a gastronomical delight. For example, will brining or marinating a pork chop make it moister? And, if brining, what temperature should the water be, how long should it soak, and how much salt is needed? Why does pounding meat increase its tenderness? What will keep guacamole from browning better – the pit or lime juice? What does baking soda do in a chocolate cake? Eggs or no eggs in fresh pasta? Like most librarians, I tend not to take information at face value. I want to know where information comes from and whether or not it is valid, based on specific factors. I’ve come to notice that evidence based, or evidence informed, practice is everywhere and has a tremendous impact on our lives. Why do you rotate the tires on your car? Evidence shows that the front tires wear more quickly (think about all those 3-pointturns, the braking, etc and therefore

  8. Effect of forensic evidence on criminal justice case processing.

    Science.gov (United States)

    Peterson, Joseph L; Hickman, Matthew J; Strom, Kevin J; Johnson, Donald J

    2013-01-01

    This study examined the role and impact of forensic evidence on case-processing outcomes in a sample of 4205 criminal cases drawn from five U.S. jurisdictions. Regression analyses demonstrated that forensic evidence played a consistent and robust role in case-processing decisions. Still, the influence of forensic evidence is time- and examination-dependent: the collection of crime scene evidence was predictive of arrest, and the examination of evidence was predictive of referral for charges, as well as of charges being filed, conviction at trial, and sentence length. The only decision outcome in which forensic evidence did not have a general effect was with regard to guilty plea arrangements. More studies are needed on the filtering of forensic evidence in different crime categories, from the crime scene to its use by investigators, prosecutors, and fact-finders, and to identify factors that shape decisions to collect evidence, submit it to laboratories, and request examinations.

  9. Evaluating Evidence Aid as a complex, multicomponent knowledge translation intervention.

    Science.gov (United States)

    Mellon, Dominic

    2015-02-01

    Evidence Aid, an initiative established by members of The Cochrane Collaboration in the aftermath of the Indian Ocean Tsunami in December 2004, celebrates its first 10 years later this year. Whilst the principles of the Evidence Aid initiative are firmly rooted in evidence-based medicine and public health practice, the initiative itself was born of a humanitarian imperative, compassion and the expressed moral duty to help. The evidence-base for Evidence Aid, (that is, for knowledge translation interventions focused on dissemination of evidence), was not, and is not, well-established This article, which is based on a presentation at the Evidence Aid Symposium on 20 September 2014, at Hyderabad, India presents a unifying conceptual framework for use when researching the impact of Evidence Aid as a knowledge translation intervention. It highlights how each of the core activities can be mapped to this framework and identifies key outcomes of interest for evaluation.

  10. Emerging evidence of ozone metabolic effects and potential mechanisms

    Science.gov (United States)

    SOT 2014 Abstract: Invitational Emerging evidence of ozone metabolic effects and potential mechanisms U.P. Kodavanti NHEERL, USEPA, Research Triangle Park, NC Recent evidence suggests that air pollutants are linked to metabolic syndrome and impact several key metabolic proce...

  11. Incorporating Qualitative Evidence in Systematic Reviews: Strategies and Challenges

    Science.gov (United States)

    Caracelli, Valerie J.; Cooksy, Leslie J.

    2013-01-01

    The quality of mixed methods systematic reviews relies on the quality of primary-level studies. The synthesis of qualitative evidence and the recent development of synthesizing mixed methods studies hold promise, but also pose challenges to evidence synthesis.

  12. [Evidence-based management of medical disposable materials].

    Science.gov (United States)

    Yang, Hai

    2009-03-01

    Evidence-based management of medical disposable materials pays attention to collect evidence comprehensively and systematically, accumulate and create evidence through its own work and also evaluate evidence strictly. This can be used as a function to guide out job. Medical disposable materials evidence system contains product register qualification, product quality certification, supplier's behavior, internal and external communication evidence. Managers can find different ways in creating and using evidence referring to specific inside and outside condition. Evidence-based management can help accelerating the development of management of medical disposable materials from traditional experience pattern to a systematic and scientific pattern. It also has the very important meaning to improve medical quality, control the unreasonable growth of medical expense and make purchase and supply chain be more efficient.

  13. Anomalous Evidence, Confidence Change, and Theory Change.

    Science.gov (United States)

    Hemmerich, Joshua A; Van Voorhis, Kellie; Wiley, Jennifer

    2016-08-01

    A novel experimental paradigm that measured theory change and confidence in participants' theories was used in three experiments to test the effects of anomalous evidence. Experiment 1 varied the amount of anomalous evidence to see if "dose size" made incremental changes in confidence toward theory change. Experiment 2 varied whether anomalous evidence was convergent (of multiple types) or replicating (similar finding repeated). Experiment 3 varied whether participants were provided with an alternative theory that explained the anomalous evidence. All experiments showed that participants' confidence changes were commensurate with the amount of anomalous evidence presented, and that larger decreases in confidence predicted theory changes. Convergent evidence and the presentation of an alternative theory led to larger confidence change. Convergent evidence also caused more theory changes. Even when people do not change theories, factors pertinent to the evidence and alternative theories decrease their confidence in their current theory and move them incrementally closer to theory change.

  14. Evidence-based treatment of metabolic myopathy

    Directory of Open Access Journals (Sweden)

    Yan LIN

    2014-05-01

    Full Text Available Objective To evaluate the current treatments and possible adverse reactions of metabolic myopathy, and to develop the best solution for evidence-based treatment.  Methods Taking metabolic myopathy, mitochondrial myopathy, lipid storage myopathy, glycogen storage diseases, endocrine myopathy, drug toxicity myopathy and treatment as search terms, retrieve in databases such as PubMed, Cochrane Library, ClinicalKey database, National Science and Technology Library (NSTL, in order to collect the relevant literature database including clinical guidelines, systematic reviews (SR, randomized controlled trials (RCT, controlled clinical trials, retrospective case analysis and case study. Jadad Scale was used to evaluate the quality of literature.  Results Twenty-eight related articles were selected, including 6 clinical guidelines, 5 systematic reviews, 10 randomized controlled trials and 7 clinical controlled trials. According to Jadad Scale, 23 articles were evaluated as high-quality literature (≥ 4, and the remaining 5 were evaluated as low-quality literature (< 4. Treatment principles of these clinical trials, efficacy of different therapies and drug safety evaluation suggest that: 1 Acid α-glycosidase (GAA enzyme replacement therapy (ERT is the main treatment for glycogen storage diseases, with taking a high-protein diet, exercising before taking a small amount of fructose orally and reducing the patient's physical activity gradually. 2 Carnitine supplementation is used in the treatment of lipid storage myopathy, with carbohydrate and low fat diet provided before exercise or sports. 3 Patients with mitochondrial myopathy can take coenzyme Q10, vitamin B, vitamin K, vitamin C, etc. Proper aerobic exercise combined with strength training is safe, and it can also enhance the exercise tolerance of patients effectively. 4 The first choice to treat the endocrine myopathy is treating primary affection. 5 Myopathies due to drugs and toxins should

  15. Evidence Based Dental Care: Integrating Clinical Expertise with Systematic Research

    OpenAIRE

    2014-01-01

    Clinical dentistry is becoming increasingly complex and our patients more knowledgeable. Evidence-based care is now regarded as the “gold standard” in health care delivery worldwide. The basis of evidence based dentistry is the published reports of research projects. They are, brought together and analyzed systematically in meta analysis, the source for evidence based decisions. Activities in the field of evidence-based dentistry has increased tremendously in the 21st century, more and more p...

  16. Evidence-based practice. The role of staff development.

    Science.gov (United States)

    Krugman, Mary

    2003-01-01

    Knowledge and use of evidence-based practice are essential to ensure best practices and safe patient outcomes. Staff development specialists must be leaders in this initiative to support clinical nurses toward improved practice outcomes. This article describes the background for understanding the historical evolution from research utilization to evidence-based practice, defines some key concepts related to evidence-based practice, and suggests essential components for building evidence-based practice programs in healthcare institutions.

  17. Evidence-based neuroethics for neurodevelopmental disorders.

    Science.gov (United States)

    Racine, Eric; Bell, Emily; Di Pietro, Nina C; Wade, Lucie; Illes, Judy

    2011-03-01

    Many neurodevelopmental disorders affect early brain development in ways that are still poorly understood; yet, these disorders can place an enormous toll on patients, families, and society as a whole and affect all aspects of daily living for patients and their families. We describe a pragmatic, evidence-based framework for engaging in empiric ethics inquiry for a large consortium of researchers in neurodevelopmental disorders and provide relevant case studies of pragmatic neuroethics. The 3 neurodevelopmental disorders that are at the focus of our research, cerebral palsy (CP), autism spectrum disorder (ASD), and fetal alcohol spectrum disorder (FASD), bring unique and intersecting challenges of translating ethically research into clinical care for children and neonates. We identify and discuss challenges related to health care delivery in CP; neonatal neurological decision making; alternative therapies; and identity, integrity, and personhood.

  18. Observational evidence favours a static universe

    CERN Document Server

    Crawford, David F

    2010-01-01

    The common attribute of all Big Bang cosmologies is that they are based on the assumption that the universe is expanding. However examination of the evidence for this expansion clearly favours a static universe. The major topics considered are: Tolman surface brightness, angular size, type 1a supernovae, gamma ray bursts, galaxy distributions, quasar distributions, X-ray background radiation, cosmic microwave background radiation, radio source counts, quasar variability and the Butcher--Oemler effect. An analysis of the best raw data for these topics shows that they are consistent with expansion only if there is evolution that cancels the effects of expansion. An alternate cosmology, curvature cosmology, is in full agreement with the raw data. This tired-light cosmology predicts a well defined static and stable universe and is fully described. It not only predicts accurate values for the Hubble constant and the temperature of cosmic microwave background radiation but shows excellent agreement with most of the...

  19. Experimental evidence for circular inference in schizophrenia

    Science.gov (United States)

    Jardri, Renaud; Duverne, Sandrine; Litvinova, Alexandra S.; Denève, Sophie

    2017-01-01

    Schizophrenia (SCZ) is a complex mental disorder that may result in some combination of hallucinations, delusions and disorganized thinking. Here SCZ patients and healthy controls (CTLs) report their level of confidence on a forced-choice task that manipulated the strength of sensory evidence and prior information. Neither group's responses can be explained by simple Bayesian inference. Rather, individual responses are best captured by a model with different degrees of circular inference. Circular inference refers to a corruption of sensory data by prior information and vice versa, leading us to `see what we expect' (through descending loops), to `expect what we see' (through ascending loops) or both. Ascending loops are stronger for SCZ than CTLs and correlate with the severity of positive symptoms. Descending loops correlate with the severity of negative symptoms. Both loops correlate with disorganized symptoms. The findings suggest that circular inference might mediate the clinical manifestations of SCZ.

  20. Dinosaur physiology. Evidence for mesothermy in dinosaurs.

    Science.gov (United States)

    Grady, John M; Enquist, Brian J; Dettweiler-Robinson, Eva; Wright, Natalie A; Smith, Felisa A

    2014-06-13

    Were dinosaurs ectotherms or fast-metabolizing endotherms whose activities were unconstrained by temperature? To date, some of the strongest evidence for endothermy comes from the rapid growth rates derived from the analysis of fossil bones. However, these studies are constrained by a lack of comparative data and an appropriate energetic framework. Here we compile data on ontogenetic growth for extant and fossil vertebrates, including all major dinosaur clades. Using a metabolic scaling approach, we find that growth and metabolic rates follow theoretical predictions across clades, although some groups deviate. Moreover, when the effects of size and temperature are considered, dinosaur metabolic rates were intermediate to those of endotherms and ectotherms and closest to those of extant mesotherms. Our results suggest that the modern dichotomy of endothermic versus ectothermic is overly simplistic.

  1. Inequality, income, and poverty: comparative global evidence.

    Science.gov (United States)

    Fosu, Augustin Kwasi

    2010-01-01

    Objectives. The study seeks to provide comparative global evidence on the role of income inequality, relative to income growth, in poverty reduction.Methods. An analysis-of-covariance model is estimated using a large global sample of 1980–2004 unbalanced panel data, with the headcount measure of poverty as the dependent variable, and the Gini coefficient and PPP-adjusted mean income as explanatory variables. Both random-effects and fixed-effects methods are employed in the estimation.Results. The responsiveness of poverty to income is a decreasing function of inequality, and the inequality elasticity of poverty is actually larger than the income elasticity of poverty. Furthermore, there is a large variation across regions (and countries) in the relative effects of inequality on poverty.Conclusion. Income distribution plays a more important role than might be traditionally acknowledged in poverty reduction, though this importance varies widely across regions and countries.

  2. Evidence of platelet activation in multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Alexander J Steven

    2008-06-01

    Full Text Available Abstract Objective A fatality in one multiple sclerosis (MS patient due to acute idiopathic thrombocytopenic purpura (ITP and a near fatality in another stimulated our interest in platelet function abnormalities in MS. Previously, we presented evidence of platelet activation in a small cohort of treatment-naive MS patients. Methods In this report, 92 normal controls and 33 stable, untreated MS patients were studied. Platelet counts, measures of platelet activation [plasma platelet microparticles (PMP, P-selectin expression (CD62p, circulating platelet microaggragtes (PAg], as well as platelet-associated IgG/IgM, were carried out. In addition, plasma protein S activity was measured. Results Compared to controls, PMP were significantly elevated in MS (p Conclusion Platelets are significantly activated in MS patients. The mechanisms underlying this activation and its significance to MS are unknown. Additional study of platelet activation and function in MS patients is warranted.

  3. Inflation and growth: the international evidence

    Directory of Open Access Journals (Sweden)

    Anthony Philip Thirlwall

    1971-09-01

    Full Text Available Although in the current climate of inflation most are concerned with its negative repercussions, its virtues as a means of growth were once extolled by the likes of Robertson, Kaldor and Rostow. Moreover, the notion of growth via inflation was an attractive proposition to less developed countries in the 1950s as they sought to accelerate the growth of output in the face of inadequate voluntary saving and inelastic tax revenue. Although there are many reasons why in theory mild inflation may be conducive to growth, this hypothesis has yet to be empirically tested. The author analyses a broad cross-section of countries with growth as an independent variable. For both developed and developing countries the hypothesis is supported by the evidence. However, for the latter there is a negative relation between inflation and growth when annual rates of inflation exceed 10 percent.

  4. Evidence of probable tuberculosis in Lithuanian mummies.

    Science.gov (United States)

    Piombino-Mascali, D; Jankauskas, R; Tamošiūnas, A; Valančius, R; Gill-Frerking, H; Spigelman, M; Panzer, S

    2015-10-01

    Tuberculosis has affected Europe for millennia and continues to be a burden upon modern society. It is estimated that one-third of the world's population is infected with Mycobacterium tuberculosis, the causative agent of this condition. Despite the introduction of control strategies, the disease continues to be one of the most common causes of death globally. Within the framework of the Lithuanian Mummy Project, seven spontaneously mummified human bodies from a church crypt in Vilnius, dating from the 18th and 19th century, were CT-scanned to assess the presence of tuberculosis or other lung diseases. We encountered pulmonary lesions suggestive of cases of pulmonary tuberculosis. In addition, one case might have been affected by extra-pulmonary tuberculosis. This report replicates the image findings from previous studies on ancient mummies that provided evidence of tuberculosis in soft tissues, thus helping reconstruct the history of this disease over time.

  5. Fiscal Reaction Function: Evidences from CESEE countries

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    Aleksandar Zdravković

    2013-12-01

    Full Text Available The aim of this paper is to improve on the methodology set in previous attempts to estimate the impact of gross government debt to primary balances in a wide set of 21 CESEE countries. Since the result of the long-lasting crisis in those countries is rising imbalance of public finances it is necessary to analyze what factors are causing such effects. Running the fixed effect, pooled and GMM regression it was found that both lagged government debt and output gap are positively related to primary balance. Moreover there was found evidence of non-linear relationship between primary balance and lagged debt, with fiscal fatigue occurrence at 70% threshold. Estimation of the augmented model shows that countercyclical response of primary balance is more pronounced in economic downturn relative to boom in cycle.

  6. Estonian Middle Semantics with Evidence from Discourse

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    Virve-Anneli Vihman

    2004-01-01

    Full Text Available This paper presents arguments for recognizing a middle voice in Estonian. The claim that the semantics of middle-marked verbs differs in a substantial way from the semantics of other intransitive constructions leads to the examination of the discourse pragmatics of these constructions, and the relationship between discourse patterns and their valency and argument properties. Various topicality measures show that the argument participant in middle clauses lies between that of the sole participant (S in intransitive clauses and the O of active transitive clauses. The results regarding the discourse behaviour of middle arguments constitute new evidence for the view that middle constructions differ from ordinary intransitive verbs, despite structural similarities, and mark a unique range on the scale of transitivity exhibited by verbs in Estonian.

  7. Course Redesign: An Evidence-Based Approach

    Directory of Open Access Journals (Sweden)

    Kathy Nomme

    2014-11-01

    Full Text Available A first year non-majors biology course, with an enrollment of around 440 students, has been redesigned from a course of traditional content and teaching style to one that emphasizes biological concepts in current global issues and incorporates active learning strategies. We were informed by the education literature incorporating many aspects of established curriculum redesign principles and extended its application to a biology course. Systematic measurement of student attitudes and collection of student feedback through a series of surveys as well as focus group interviews proved to be invaluable in the course redesign process. The information gathered over a two-year period enabled us to fine-tune the course content and teaching strategies effectively to better meet the interests of students in the non-majors course as was documented by the evidence gathered in this research.

  8. Treatment of intracerebral hemorrhage: the clinical evidences.

    Science.gov (United States)

    Sterzi, R; Vidale, S

    2004-03-01

    Of all strokes 10% to 15% are intracerebral hemorrhage, primary ICH accounting for more than 75% of cases. A correct evaluation and management must start in the emergency room, in particular for patients who rapidly deteriorate. The diffusion of organized care for stroke patients and the availability of the stroke units in Italian hospitals, may represent a further opportunity to improve the outcome of patients with ICH. Despite the bulk of evidences coming from the randomized clinical therapeutic trials for acute ischemic stroke, the available data for randomized surgical trials are scanty. In these small randomized studies, neither surgical nor medical treatment has conclusively been shown to benefit patients with ICH. Surgical techniques are improving but it is important to find out the time window during which surgical evacuation is most effective with respect to the long-term outcome. The use of thrombolytic therapy to promote the resolution of ventricular blood clots appears to be promising.

  9. An information gap in DNA evidence interpretation.

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    Mark W Perlin

    Full Text Available Forensic DNA evidence often contains mixtures of multiple contributors, or is present in low template amounts. The resulting data signals may appear to be relatively uninformative when interpreted using qualitative inclusion-based methods. However, these same data can yield greater identification information when interpreted by computer using quantitative data-modeling methods. This study applies both qualitative and quantitative interpretation methods to a well-characterized DNA mixture and dilution data set, and compares the inferred match information. The results show that qualitative interpretation loses identification power at low culprit DNA quantities (below 100 pg, but that quantitative methods produce useful information down into the 10 pg range. Thus there is a ten-fold information gap that separates the qualitative and quantitative DNA mixture interpretation approaches. With low quantities of culprit DNA (10 pg to 100 pg, computer-based quantitative interpretation provides greater match sensitivity.

  10. Evidence for a Lattice Weak Gravity Conjecture

    CERN Document Server

    Heidenreich, Ben; Rudelius, Tom

    2016-01-01

    The Weak Gravity Conjecture postulates the existence of superextremal charged particles, i.e. those with mass smaller than or equal to their charge in Planck units. We present further evidence for our recent observation that in known examples a much stronger statement is true: an infinite tower of superextremal particles of different charges exists. We show that effective Kaluza-Klein field theories and perturbative string vacua respect the Sublattice Weak Gravity Conjecture, namely that a finite index sublattice of the full charge lattice exists with a superextremal particle at each site. In perturbative string theory we show that this follows from modular invariance. However, we present counterexamples to the stronger possibility that a superextremal state exists at every lattice site, including an example in which the lightest charged state is subextremal. The Sublattice Weak Gravity Conjecture has many implications both for abstract theories of quantum gravity and for real-world physics. For instance, it ...

  11. EVIDENCE-BASED USE OF EPLERENONE

    Directory of Open Access Journals (Sweden)

    S. R. Gilyarevski

    2012-01-01

    Full Text Available Data of the negative effect of high concentrations of aldosterone in the blood for cardiovascular disease, which served as the theoretical basis for wider use in clinical practice of the drugs belonging to the class of aldosterone receptor blockers is presented. Evidence-based data on efficacy and safety of aldosterone receptor blockers, which were obtained in the course of several randomized clinical trials is performed. Particular attention is paid to aspects of the clinical use of selective aldosterone receptor blocker eplerenone, including current data, which makes reasonable extension of indications for its use in treating patients with chronic heart failure. Data on indications of eplerenone use in patients with hypertension, especially in the case of associated target organ damage is presented.

  12. Sepsis management: An evidence-based approach.

    Science.gov (United States)

    Baig, Muhammad Akbar; Shahzad, Hira; Jamil, Bushra; Hussain, Erfan

    2016-03-01

    The Surviving Sepsis Campaign (SSC) guidelines have outlined an early goal directed therapy (EGDT) which demonstrates a standardized approach to ensure prompt and effective management of sepsis. Having said that, there are barriers associated with the application of evidence-based practice, which often lead to an overall poorer adherence to guidelines. Considering the global burden of disease, data from low- to middle-income countries is scarce. Asia is the largest continent but most Asian countries do not have a well-developed healthcare system and compliance rates to resuscitation and management bundles are as low as 7.6% and 3.5%, respectively. Intensive care units are not adequately equipped and financial concerns limit implementation of expensive treatment strategies. Healthcare policy-makers should be notified in order to alleviate financial restrictions and ensure delivery of standard care to septic patients.

  13. Strategies for risk communication: evolution, evidence, experience.

    Science.gov (United States)

    Tucker, W Troy; Ferson, Scott

    2008-04-01

    This volume presents the proceedings of the symposium entitled Strategies for Risk Communication: Evolution, Evidence, Experience. The symposium was held in Montauk, Long Island, New York on May 15-17, 2006. It explored practical methods and robust theories of risk communication informed by recent research in risk perception, neuroscience, and the evolutionary social sciences. The symposium focused on what experimental, survey, and brain imaging research has uncovered about how humans process and perceive uncertainty and risks and what the evolutionary history of humans suggests about how we understand and respond to risks. The purpose of the symposium and of this collection of papers is to begin to synthesize the findings from these diverse fields and inform the development of practical strategies for risk communication.

  14. [Medical anthropology evidences on the Pishtaco origin].

    Science.gov (United States)

    de Pribyl, Rosario

    2010-03-01

    This paper will contribute to the scientific development of a new approach on the pishtaco in Peru by means of medical anthropological analysis. The model emphasizes presentation and analysis of historical, pharmaceutical, and anthropological evidence supporting use of human tissues with specific medical goals in Peruvian and European regions. We can find the origin of this phenomenon around the sixteen and seventeen centuries in Europe: The pishtaco has no an Andean origin. The methodology and main conclusions of this paper could provide to the scientific community an alternative perspective to the conventional anthropological and ethnological research, as an example of a medical anthropological analysis of the pishtaco character. Professionals involved in intercultural health projects could have a new insight on this issue thanks to these results. They will obtain an adequate historical-cultural context for the interpretation and understanding of people and native communities' beliefs about health, body and medical systems.

  15. MIRROR THERAPY: A REVIEW OF EVIDENCES

    Directory of Open Access Journals (Sweden)

    Aishath Najiha

    2015-06-01

    Full Text Available The aim of this review was to identify and summarize the existing evidences on mirror box therapy for the management of various musculoskeletal conditions. A systemic literature search was performed to identify studies concerning mirror therapy. The included journal articles were reviewed and assessed for its significance. Fifty one studies were identified and reviewed. Five different patient categories were studied: 24 studies focussed on mirror therapy after stroke, thirteen studies focussed on mirror therapy after an amputation, three studies focussed on mirror therapy with complex regional pain syndrome patients, two studies on mirror therapy for cerebral palsy and one study focussed on mirror therapy after a fracture. The articles reviewed showed a trend that mirror therapy is effective in stroke, phantom limb pain, complex regional pain syndrome, cerebral palsy and fracture rehabilitation.

  16. Numerical Evidence for Thermally Induced Monopoles

    CERN Document Server

    Wirnsberger, Peter; Lightwood, Roger Adam; Šarić, Anđela; Dellago, Christoph; Frenkel, Daan

    2016-01-01

    Electrical charges are conserved. The same would be expected to hold for magnetic charges, yet magnetic monopoles have never been observed. It is therefore surprising that the laws of non-equilibrium thermodynamics, combined with Maxwell's equations, suggest that colloidal particles heated or cooled in certain polar or paramagnetic solvents may behave as if they carry an electrical/magnetic charge [J. Phys. Chem. B $\\textbf{120}$, 5987 (2016)]. Here we present numerical simulations that show that the field distribution around a pair of such heated/cooled colloidal particles agrees quantitatively with the theoretical predictions for a pair of oppositely charged electrical or magnetic monopoles. However, in other respects, the non-equilibrium colloids do not behave as monopoles: they cannot be moved by a homogeneous applied field. The numerical evidence for the monopole-like fields around heated/cooled colloids is crucial because the experimental and numerical determination of forces between such colloids would...

  17. SNC meteorites - Evidence against an asteroidal origin

    Science.gov (United States)

    Ashwal, L. D.; Warner, J. L.; Wood, C. A.

    1982-01-01

    About 1.3 billion years ago, on one or more distant planetary bodies, silicate melts formed and produced cumulate rocks which eventually made their way to earth. Nine of these rocks have been recovered. Three distinct groups are involved, including shergottites, nakhlites, and chassignites (abbreviated as SNC). The young crystallization ages and other chemical features of SNC meteorites have prompted several workers to suggest that the specimens may be samples of igneous rock, ejected from the surface of Mars during an impact event. Others have rejected the Martian origin of SNC meteorites in favor of a more traditional asteroidal parent body. The present investigation shows that the petrologic, geochemical, and isotopic evidence is inconsistent with an asteroidal origin for SNC meteorites. It is found that the characteristics of SNC meteorites argue convincingly against their origin in a planetary object as small as the largest asteroid. That these meteorites may be fragments of the Martian surface still remains the most likely possibility.

  18. Archaeogenomic evidence reveals prehistoric matrilineal dynasty

    Science.gov (United States)

    Kennett, Douglas J.; Plog, Stephen; George, Richard J.; Culleton, Brendan J.; Watson, Adam S.; Skoglund, Pontus; Rohland, Nadin; Mallick, Swapan; Stewardson, Kristin; Kistler, Logan; LeBlanc, Steven A.; Whiteley, Peter M.; Reich, David; Perry, George H.

    2017-01-01

    For societies with writing systems, hereditary leadership is documented as one of the hallmarks of early political complexity and governance. In contrast, it is unknown whether hereditary succession played a role in the early formation of prehistoric complex societies that lacked writing. Here we use an archaeogenomic approach to identify an elite matriline that persisted between 800 and 1130 CE in Chaco Canyon, the centre of an expansive prehistoric complex society in the Southwestern United States. We show that nine individuals buried in an elite crypt at Pueblo Bonito, the largest structure in the canyon, have identical mitochondrial genomes. Analyses of nuclear genome data from six samples with the highest DNA preservation demonstrate mother–daughter and grandmother–grandson relationships, evidence for a multigenerational matrilineal descent group. Together, these results demonstrate the persistence of an elite matriline in Chaco for ∼330 years. PMID:28221340

  19. Evidence for reconnection at Saturn's magnetopause

    Science.gov (United States)

    McAndrews, H. J.; Owen, C. J.; Thomsen, M. F.; Lavraud, B.; Coates, A. J.; Dougherty, M. K.; Young, D. T.

    2008-04-01

    Observations of Saturn's magnetopause by the Cassini Plasma Spectrometer (CAPS) and magnetometer have revealed clear instances of magnetic reconnection signatures, two of which are described here. Both encounters occurred at the equator in the prenoon sector as Cassini was exiting the magnetosphere. Evidence of heating in the electrons and ions is highly suggestive of energization comparable to that associated with the reconnection process at Earth. In one case, the fields are strongly antiparallel and the magnetic data indicate the presence of a locally open magnetic field. In the other example, magnetic data indicate a locally closed magnetic field compatible with the field lines being locally parallel, but the particle signatures lead to the conclusion of a distant reconnection site poleward of the cusps being active. The reconnection voltage for the first case is calculated to be 48 kV, which is of the same order as previous estimates at Saturn. This is lower than the corotational voltage but is not insignificant.

  20. Dark energy observational evidence and theoretical models

    CERN Document Server

    Novosyadlyj, B; Shtanov, Yu; Zhuk, A

    2013-01-01

    The book elucidates the current state of the dark energy problem and presents the results of the authors, who work in this area. It describes the observational evidence for the existence of dark energy, the methods and results of constraining of its parameters, modeling of dark energy by scalar fields, the space-times with extra spatial dimensions, especially Kaluza---Klein models, the braneworld models with a single extra dimension as well as the problems of positive definition of gravitational energy in General Relativity, energy conditions and consequences of their violation in the presence of dark energy. This monograph is intended for science professionals, educators and graduate students, specializing in general relativity, cosmology, field theory and particle physics.

  1. Paleoambientes litorales durante el inicio de la trasgresión marina holocena en bahía Lapataia, canal Beagle, parque nacional Tierra del Fuego Littoral paleoenvironments during the beginning of the Holocene marine transgression in Lapataia Bay, Beagle Channel, National Park of Tierra del Fuego

    Directory of Open Access Journals (Sweden)

    Jorge Rabassa

    2009-12-01

    Full Text Available Los sitios Aserradero Lapataia 1 y 2 presentan depósitos limo-arcillosos portadores de valvas de moluscos: Mulinia edulis, Mytilus chilensis, Aulacomya atra y Yoldia sp. Además predominan los quistes de dinoflagelados, revestimientos de foraminíferos bentónicos y huevos de copépodos. Valvas de Mulinia edulis fueron datadas radiocarbónicamente en 8.094 ± 43 (AA74047 y 8.167 ± 43 (AA74048 a A.P. En Arroyo Baliza depósitos limo-arcillosos son portadores de Venus antiqua, Aulacomya atra, Mytilus chilensis, entre otros. La microflora está dominada por dinoquistes protoperidinioideos, acritarcos y restos de copépodos. Se sugiere ambientes marino-marginales, con baja a moderada salinidad, y altas concentraciones de nutrientes en las aguas superficiales. La datación radiocarbónica sobre Venus antiqua en Arroyo Baliza indica 2.844 ± 34 a A.P. (AA74046. Aserradero Lapataia confirma las edades más antiguas conocidas para la fase estuárica de la transgresión holocena en el canal Beagle. Arroyo Baliza aporta nueva evidencia de la fase regresiva en este canal durante el Holoceno tardío.The Aserradero Lapataia 1 and 2 sites present clayey silty sediments including mollusk shell; Mulinia edulis, Mytilus chilensis, Aulacomya atra and Yoldia sp. Besides, dinoflagelate cysts, covers of benthonic foraminifera and copepod eggs are dominant. The microflora is represented by sporomorphs and fresh to salty water microplancton. Radiocarbon dates on Mulinia edulis shells yielded ages of 8094 ± 43 (AA74047 and 8167 ± 43 (AA74048 yr B.P. At Arroyo Baliza, clayey silts were found including Venus antiqua, Aulacomya atra, Mytilus chilensis, among others, accompanied by acritarchs and remnants of copepods. This association suggests marginal marine environments, with low to moderate salinity, and high nutrient concentration in the surface waters. Radiocarbon dating on Venus antiqua shells yielded 2844 ± 34 yr B.P. (AA74046. Marine deposits of the Aserradero

  2. Constructing a New Theory from Old Ideas and New Evidence

    Science.gov (United States)

    Rhodes, Marjorie; Wellman, Henry

    2013-01-01

    A central tenet of constructivist models of conceptual development is that children's initial conceptual level constrains how they make sense of new evidence and thus whether exposure to evidence will prompt conceptual change. Yet little experimental evidence directly examines this claim for the case of sustained, fundamental conceptual…

  3. Evidence-Based Medicine in the Education of Psychiatrists

    Science.gov (United States)

    Srihari, Vinod

    2008-01-01

    Objective: Evidence-based medicine has an important place in the teaching and practice of psychiatry. Attempts to teach evidence-based medicine skills can be weakened by conceptual confusions feeding a false polarization between traditional clinical skills and evidence-based medicine. Methods: The author develops a broader conception of clinical…

  4. From evidence to action. Understanding clinical practice guidelines.

    NARCIS (Netherlands)

    Poolman, R.W.; Verheyen, C.C.P.M.; Kerkhoffs, G.M.; Bhandari, M.; Schünemann, H.J.

    2009-01-01

    Good guidelines will help us to take evidence into practice. In a survey among Dutch orthopedic surgeons, development and use of evidence-based guidelines was perceived as one of the best ways of moving from opinion-based to evidence-based orthopedic practice. The increasing number of guidelines mea

  5. 29 CFR 2700.63 - Evidence; presentation of case.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Evidence; presentation of case. 2700.63 Section 2700.63 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION PROCEDURAL RULES Hearings § 2700.63 Evidence; presentation of case. (a) Relevant evidence, including...

  6. How Do Dentists Understand Evidence and Adopt It in Practice?

    Science.gov (United States)

    Sbaraini, Alexandra; Carter, Stacy M.; Evans, R. Wendell

    2012-01-01

    Although there is now a large evidence-based dentistry literature, previous investigators have shown that dentists often consider research evidence irrelevant to their practice. To understand why this is the case, we conducted a qualitative study. Objective: Our aim was to identify how dentists define evidence and how they adopt it in practice.…

  7. 42 CFR 405.1118 - Obtaining evidence from the MAC.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Obtaining evidence from the MAC. 405.1118 Section... Council Review § 405.1118 Obtaining evidence from the MAC. A party may request and receive a copy of all... these items. If a party requests evidence from the MAC and an opportunity to comment on that...

  8. 42 CFR 423.2118 - Obtaining evidence from the MAC.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Obtaining evidence from the MAC. 423.2118 Section..., MAC review, and Judicial Review § 423.2118 Obtaining evidence from the MAC. An enrollee may request... the costs of providing these items. If an enrollee requests evidence from the MAC and an...

  9. Evidence into practice; upper respiratory tract infections in children

    NARCIS (Netherlands)

    Boonacker, C.W.B.

    2012-01-01

    Transfer of evidence into practice is often slow and therefore remains an important challenge. Factors influencing this process include awareness and agreement with available evidence, feelings about the applicability of the evidence to one’s own patients and pressure from patients to start or refra

  10. Evidence-Based Practice in Rehabilitation Counseling: Perceptions and Practices

    Science.gov (United States)

    Bezyak, Jill L.; Kubota, Coleen; Rosenthal, David

    2010-01-01

    This study describes certified rehabilitation counselors' attitudes (n=163) about evidence based practice, knowledge and skills related to obtaining and evaluating evidence, use of literature in practice, availability of information, and perceived barriers to evidence-based practice. Responses related to knowledge and skills were mixed with strong…

  11. Application of Evidence-based Prosthodontics in Practice

    Institute of Scientific and Technical Information of China (English)

    雷雨; 朱智敏; CHAO Yong-lie; SHI Zong-dao; MENG Yu-kun

    2006-01-01

    The concepts and progress of evidence-based dentistry were introduced in this critical review. An extensive PubMed search was conducted to provide sound evidences for some frequently encountered problems in prosthodontic daily practice. Conlusively, it is important for prosthodontists to keep current by looking for efficient ways of interpreting high quality evidences to clinical practice.

  12. Evidence Valued and Used by Health Promotion Practitioners

    Science.gov (United States)

    Li, V.; Carter, S. M.; Rychetnik, L.

    2015-01-01

    The use of evidence has become a foundational part of health promotion practice. Although there is a general consensus that adopting an evidence-based approach is necessary for practice, disagreement remains about what types of evidence practitioners should use to guide their work. An empirical understanding of how practitioners conceptualize and…

  13. E-Learning and Evidence Based Practice in Schools

    Science.gov (United States)

    Quong, Terrence

    2016-01-01

    JCTIC has used open source software to develop a unique school online environment that has made evidence based practice viable in their school. In this paper the proposition is made that eLearning enables evidence based practice which in turn leads to improved student outcomes. Much has been written about evidence based practice in schools, but…

  14. The ABCs of Evidence-Based Practice for Teachers

    Science.gov (United States)

    Kretlow, Allison G.; Blatz, Sharon L.

    2011-01-01

    It is critical teachers adhere to federal policies regarding evidence-based practices. Quickly identifying and effectively using evidence-based programs and practices is particularly important for special educators, because students in special education often already have academic or behavioral deficits. Using evidence-based practices with…

  15. 19 CFR 148.112 - Evidence of purchase.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Evidence of purchase. 148.112 Section 148.112 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE... Evidence of purchase. A sales slip, invoice, or other evidence of purchase, shall be presented with...

  16. 20 CFR 366.5 - Consideration of evidence.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Consideration of evidence. 366.5 Section 366... COLLECTION OF DEBTS BY FEDERAL TAX REFUND OFFSET § 366.5 Consideration of evidence. Evidence submitted by the... of such debt is past-due and legally enforceable will be made only by such officials or employees....

  17. Current clinical evidence on pioglitazone pharmacogenomics

    Directory of Open Access Journals (Sweden)

    Marina eKawaguchi-Suzuki

    2013-11-01

    Full Text Available Pioglitazone is the most widely used thiazolidinedione and acts as an insulin-sensitizer through activation of the Peroxisome Proliferator-Activated Receptor-γ (PPARγ. Pioglitazone is approved for use in the management of type 2 diabetes mellitus, but its use in other therapeutic areas is increasing due to pleiotropic effects. In this hypothesis article, the current clinical evidence on pioglitazone pharmacogenomics is summarized and related to variability in pioglitazone response. How genetic variation in the human genome affects the pharmacokinetics and pharmacodynamics of pioglitazone was examined. For pharmacodynamic effects, hypoglycemic and anti-atherosclerotic effects, risks of fracture or edema, and the increase in body mass index in response to pioglitazone based on genotype were examined. The genes CYP2C8 and PPARG are the most extensively studied to date and selected polymorphisms contribute to respective variability in pioglitazone pharmacokinetics and pharmacodynamics. We hypothesized that genetic variation in pioglitazone pathway genes contributes meaningfully to the clinically observed variability in drug response. To test the hypothesis that genetic variation in PPARG associates with variability in pioglitazone response, we conducted a meta-analysis to synthesize the currently available data on the PPARG p.Pro12Ala polymorphism. The results showed that PPARG 12Ala carriers had a more favorable change in fasting blood glucose from baseline as compared to patients with the wild-type Pro12Pro genotype (p=0.018. Unfortunately, findings for many other genes lack replication in independent cohorts to confirm association; further studies are needed. Also, the biological functionality of these polymorphisms is unknown. Based on current evidence, we propose that pharmacogenomics may provide an important tool to individualize pioglitazone therapy and better optimize therapy in patients with T2DM or other conditions for which pioglitazone

  18. Evidence of Historical Supernovae in Ice Cores

    Science.gov (United States)

    Young, Donna

    2011-05-01

    Within the framework of the U.S. Greenland Ice Core Science Project (GISP2), an ice core, known as the GISP H-Core, was collected in June, 1992 adjacent to the GISP2 summit drill site. The project scientists, Gisela A.M. Dreschhoff and Edward J. Zeller, were interested in dating solar proton events with volcanic eruptions. The GISP2-H 122-meter firn and ice core is a record of 415 years of liquid electrical conductivity (LEC) and nitrate concentrations, spanning the years 1992 at the surface through 1577 at the bottom. At the National Ice Core Laboratory in Denver, Colorado, the core (beneath the 12-meter firn) was sliced into 1.5 cm sections and analyzed. The resulting data set consisted of 7,776 individual analyses. The ultrahigh resolution sampling technique resulted in a time resolution of one week near the surface and one month at depth. The liquid electrical conductivity (LEC) sequence contains signals from a number of known volcanic eruptions and provides a dating system at specific locations along the core. The terrestrial and solar background nitrate records show seasonal and annual variations, respectively. However, major nitrate anomalies within the record do not correspond to any known terrestrial or solar events. There is evidence that these nitrate anomalies could be a record of supernovae events. Cosmic X-rays ionize atmospheric nitrogen, producing excess nitrate that is then deposited in the Polar Regions. The GISP2-H ice core has revealed nitrate anomalies at the times of the Tycho and Kepler supernovae. The Cassiopeia A supernova event may be documented in the core as well. We have developed a classroom activity for high school and college students, in which they examine several lines of evidence in the Greenland ice core, discriminating among nearby and mid-latitude volcanic activity, solar proton events, and supernovae. Students infer the date of the Cassiopeia A supernova.

  19. Claiming Evidence from Non-Evidence: A Reply to Morton and Harper

    Science.gov (United States)

    Bialystok, Ellen

    2009-01-01

    Morton and Harper (2007 ) argue that research presented in support of a bilingual advantage in the development of executive control has been confounded with social class, the actual mechanism for group differences. As evidence, they report a study in which a small group of monolingual and bilingual 6- and 7-year-olds performed similarly on a Simon…

  20. Evidence-Based Practice and School Libraries: Interconnections of Evidence, Advocacy, and Actions

    Science.gov (United States)

    Todd, Ross J.

    2015-01-01

    This author states that a professional focus on evidence based practice (EBP) for school libraries emerged from the International Association of School Librarianship conference when he presented the concept. He challenged the school library profession to actively engage in professional and reflective practices that chart, measure, document, and…

  1. Operationalizing Evidence-Based Practice: The Development of an Institute for Evidence-Based Social Work

    Science.gov (United States)

    Regehr, Cheryl; Stern, Susan; Shlonsky, Aron

    2007-01-01

    Although evidence-based practice (EBP) has received increasing attention in social work in the past few years, there has been limited success in moving from academic discussion to engaging social workers in the process of implementing EBP in practice. This article describes the challenges, successes, and future aims in the process of developing a…

  2. Military Rule of Evidence 404(b): Toothless Giant of the Evidence World

    Science.gov (United States)

    1996-04-01

    prosecution alleged that he had sent a poisoned box of "bromo seltzer " to Harry Cornish, his intended victim, who had then accidentally poisoned Mrs. Adams...U.S. 824 (1988). 393 See, e.g., United States v. Bender , 33 M.J. 111, 112 (C.M.A. 1991) (quoting the trial judge’s reasoning for admitting evidence of

  3. Pediatric Depression: Is There Evidence to Improve Evidence-Based Treatments?

    Science.gov (United States)

    Brent, David A.; Maalouf, Fadi T.

    2009-01-01

    Although there have been advances in our ability to treat child and adolescent depression, use of evidence-based treatments still results in many patients with residual symptoms. Advances in our understanding of cognitive, emotional, and ecological aspects of early-onset depression have the potential to lead to improvements in the assessment and…

  4. [Hierarchy of evidence: levels of evidence and grades of recommendation from current use].

    Science.gov (United States)

    Manterola, Carlos; Asenjo-Lobos, Claudla; Otzen, Tamara

    2014-12-01

    There are multiple proposals and classifications that hierarchize evidence, which may confuse those who are dedicated to generate it both in health technology assessments, as for the development of clinical guidelines, etc. The aim of this manuscript is to describe the most commonly used classifications of levels of evidence and grades of recommendation, analyzing their main differences and applications so that the user can choose the one that better suits your needs and take this health decisions basing their practice on the best available evidence. A systematic literature search was performed in PubMed and MEDLINE databases and in Google, Yahoo and Ixquick search engines. A wealth of information concerning levels of evidence and degrees recommendation was obtained. It was summarized the information of the 11 proposals more currently used (CTFPHC, Sackett, USPSTF, CEBM, GRADE, SIGN, NICE, NHMRC, PCCRP, ADA y ACCF/AHA), between which it emphasizes the GRADE WORKING GROUP, incorporated by around 90 national and international organizations such as the World Health Organization, The Cochrane Library, American College of Physicians, American Thoracic Society, UpToDate, etc.; and locally by the Ministry of Health to create clinical practice guidelines.

  5. Information literacy for evidence-based practice in perianesthesia nurses: readiness for evidence-based practice.

    Science.gov (United States)

    Ross, Jacqueline

    2010-04-01

    Information literacy, the recognition of information required, and the development of skills for locating, evaluating, and effectively using relevant evidence is needed for evidence-based practice (EBP). The purpose of this study was to examine perianesthesia nurses' perception of searching skills and access to evidence sources. The design was a descriptive, exploratory survey. The sample consisted of ASPAN members (n = 64) and nonmembers (n = 64). The Information Literacy for Evidence-Based Nursing Practice instrument was used. Findings were that ASPAN members read more journal articles, were more proficient with computers, and used Cumulative Index to Nursing and Allied Health Literature (CINAHL) more frequently than nonmembers. The three top barriers to use of research were: lack of understanding of organization or structure of electronic databases, lack of skills to critique and/or synthesize the literature, and difficulty in accessing research materials. In conclusion, education is needed for critiquing literature and understanding electronic databases and research articles to promote EBP in perianesthesia areas.

  6. Means of Evidence and Evidence Collection in Contested Procedure in Kosovo

    Directory of Open Access Journals (Sweden)

    Mr.Sc. Makfirete Krasniqi

    2015-12-01

    Full Text Available The purpose of this paper is to serve as a helpful tool for students, jurists, lawyers, judges and others, in the profesional and scientific aspect. In ruling a contested procedure in a professional manner, the court has to find the truth, so that the contested procedure is most efficient until reaching the final verdict. In my research, I intend to enrich the science with my knowledge in the field of contested procedure. In this study I have used analytical, comparative, synthesis, generalization and other methods. Those reading this paper will understand how evidence is the most important part in a fair trial, since failure to prove claims very often leads towards an incorrect situation; they will understand how difficult and painful would be forfeiting rights for the litigating party, which would lead to serious changes, such as losing property, losing a job, compensation of personal income, compensation for damage caused. The paper in itself contains deposited evidence, which maintain the level of estimation from the court in order to make a judgment in a contested procedure with a court verdict. In this paper I present the subject of: “Means of evidence and evidence collection in contested procedure”, where I have tried to research the theory but also the practice in contested proceedings, addressing the positive aspects, the deficiencies and novelties. In the legal provisions of the Law on Contested Procedure of theRepublicofKosovo, no. 03/L-006, of 30 June 2008, and Law no. 04/L-118, of 13 September 2012, on amendments to the Law on Contested Procedure, evidentiary means and evidence collection are included in chapter XXII.

  7. School Librarianship and Evidence Based Practice: Progress, Perspectives, and Challenges

    Directory of Open Access Journals (Sweden)

    Ross J. Todd

    2009-06-01

    Full Text Available Objective – This paper provides an overview of progress and developments surrounding evidence based practice in school librarianship, and seeks to provide a picture of current thinking about evidence based practice as it relates to the field. It addresses current issues and challenges facing the adoption of evidence based practice in school librarianship.Methods – The paper is based on a narrative review of a small but growing body of literature on evidence based practice in school librarianship, set within a broader perspective of evidence based education. In addition, it presents the outcomes of a collaborative process of input from 200 school libraries leaders collected at a School Library summit in 2007 specifically to address the emerging arena of evidence based practice in this field.Results – A holistic model of evidence based practice for school libraries is presented, centering on three integrated dimensions of evidence: evidence for practice, evidence in practice, and evidence of practice.Conclusion – The paper identifies key challenges ahead if evidence based school librarianship is to develop further. These include: building research credibility within the broader educational environment; the need for ongoing review and evaluation of the diverse body of research in education, librarianship and allied fields to make quality evidence available in ways that can enable practicing school librarians to build a culture of evidence based practice; development of tools, strategies, and exemplars to use to facilitate evidence based decision-making; and, ensuring that the many and diverse advances in education and librarianship become part of the practice of school librarianship.

  8. Hail the impossible: p-values, evidence, and likelihood.

    Science.gov (United States)

    Johansson, Tobias

    2011-04-01

    Significance testing based on p-values is standard in psychological research and teaching. Typically, research articles and textbooks present and use p as a measure of statistical evidence against the null hypothesis (the Fisherian interpretation), although using concepts and tools based on a completely different usage of p as a tool for controlling long-term decision errors (the Neyman-Pearson interpretation). There are four major problems with using p as a measure of evidence and these problems are often overlooked in the domain of psychology. First, p is uniformly distributed under the null hypothesis and can therefore never indicate evidence for the null. Second, p is conditioned solely on the null hypothesis and is therefore unsuited to quantify evidence, because evidence is always relative in the sense of being evidence for or against a hypothesis relative to another hypothesis. Third, p designates probability of obtaining evidence (given the null), rather than strength of evidence. Fourth, p depends on unobserved data and subjective intentions and therefore implies, given the evidential interpretation, that the evidential strength of observed data depends on things that did not happen and subjective intentions. In sum, using p in the Fisherian sense as a measure of statistical evidence is deeply problematic, both statistically and conceptually, while the Neyman-Pearson interpretation is not about evidence at all. In contrast, the likelihood ratio escapes the above problems and is recommended as a tool for psychologists to represent the statistical evidence conveyed by obtained data relative to two hypotheses.

  9. Child abduction murder: the impact of forensic evidence on solvability.

    Science.gov (United States)

    Brown, Katherine M; Keppel, Robert D

    2012-03-01

    This study examined 733 child abduction murders (CAMs) occurring from 1968 to 2002 to explore the influence of forensic evidence on case solvability in CAM investigations. It was hypothesized that the presence of forensic evidence connecting the offender to the crime would enhance case solvability in murder investigations of abducted children. This study examined the impact of CAM of different types of forensic evidence and the impact of the summed total of forensic evidence items on case solvability by controlling for victim age, victim race, victim gender, and victim-offender relationship. Time and distance theoretical predictors were also included. Binomial logistic regression models were used to determine whether forensic evidence was a critical solvability factor in murder investigations of abducted children. This research indicated that, while forensic evidence increased case solvability, the impact of forensic evidence on solvability was not as important as other solvability factors examined.

  10. Modification of evidence theory based on feature extraction

    Institute of Scientific and Technical Information of China (English)

    DU Feng; SHI Wen-kang; DENG Yong

    2005-01-01

    Although evidence theory has been widely used in information fusion due to its effectiveness of uncertainty reasoning, the classical DS evidence theory involves counter-intuitive behaviors when high conflict information exists. Many modification methods have been developed which can be classified into the following two kinds of ideas, either modifying the combination rules or modifying the evidence sources. In order to make the modification more reasonable and more effective, this paper gives a thorough analysis of some typical existing modification methods firstly, and then extracts the intrinsic feature of the evidence sources by using evidence distance theory. Based on the extracted features, two modified plans of evidence theory according to the corresponding modification ideas have been proposed. The results of numerical examples prove the good performance of the plans when combining evidence sources with high conflict information.

  11. Evidence-based nursing practice: are we there yet?

    Science.gov (United States)

    Ervin, Naomi E

    2002-01-01

    The volume of evidence for nursing practice has increased as a result of research and scientific discoveries. Yet we are still struggling with the dilemma of how to get evidence into nursing practice. Estimates are that it takes 20 years before innovations are fully put into use. Research is one type of knowledge to be used in practice. Nursing and patient care would benefit from moving more toward knowledge based on research and evidence. This article reviews barriers to and facilitators of using evidence in nursing practice and discusses a model for promoting the systematic use of evidence in practice. The author also offers suggestions for increasing the evidence base of nursing practice. Using evidence in nursing practice is important for all nurses, but requires more that the attention of the individual nurse.

  12. Geochemical Evidence for a Terrestrial Magma Ocean

    Science.gov (United States)

    Agee, Carl B.

    1999-01-01

    The aftermath of phase separation and crystal-liquid fractionation in a magma ocean should leave a planet geochemically differentiated. Subsequent convective and other mixing processes may operate over time to obscure geochemical evidence of magma ocean differentiation. On the other hand, core formation is probably the most permanent, irreversible part of planetary differentiation. Hence the geochemical traces of core separation should be the most distinct remnants left behind in the mantle and crust, In the case of the Earth, core formation apparently coincided with a magma ocean that extended to a depth of approximately 1000 km. Evidence for this is found in high pressure element partitioning behavior of Ni and Co between liquid silicate and liquid iron alloy, and with the Ni-Co ratio and the abundance of Ni and Co in the Earth's upper mantle. A terrestrial magma ocean with a depth of 1000 km will solidify from the bottom up and first crystallize in the perovskite stability field. The largest effect of perovskite fractionation on major element distribution is to decrease the Si-Mg ratio in the silicate liquid and increase the Si-Mg ratio in the crystalline cumulate. Therefore, if a magma ocean with perovskite fractionation existed, then one could expect to observe an upper mantle with a lower than chondritic Si-Mg ratio. This is indeed observed in modern upper mantle peridotites. Although more experimental work is needed to fully understand the high-pressure behavior of trace element partitioning, it is likely that Hf is more compatible than Lu in perovskite-silicate liquid pairs. Thus, perovskite fractionation produces a molten mantle with a higher than chondritic Lu-Hf ratio. Arndt and Blichert-Toft measured Hf isotope compositions of Barberton komatiites that seem to require a source region with a long-lived, high Lu-Hf ratio. It is plausible that that these Barberton komatiites were generated within the majorite stability field by remelting a perovskite

  13. Weakening forensic science in Spain: from expert evidence to documentary evidence.

    Science.gov (United States)

    Lucena-Molina, Jose-Juan; Pardo-Iranzo, Virginia; Gonzalez-Rodriguez, Joaquin

    2012-07-01

    An amendment in 2002 to the Spanish Code of Criminal Procedure converted into documentary evidence the expert reports prepared by official laboratories aimed at determining the nature, weight, and purity of seized drugs. In most cases, experts are spared from appearance before the courts. This is likely to be extended to other forensic fields. After an overview of criminalistic identification in current forensic science, the objectivity and reliability concepts used by jurists and scientists are considered by comparing the paradigm of individualization with that of likelihood. Subsequently, a detailed critical study is made on the above-mentioned Spanish legal reform, and a comparison is made with the decision on the Melendez-Diaz v. Massachusetts case as ruled by the Supreme Court of the United States. Although the reform is in compliance with the Spanish Constitution, it is at odds with science, in particular regarding the logic underpinning the scientific evaluation of evidence.

  14. Seismicity in Pennsylvania: Evidence for Anthropogenic Events?

    Science.gov (United States)

    Homman, K.; Nyblade, A.

    2015-12-01

    The deployment and operation of the USArray Transportable Array (TA) and the PASEIS (XY) seismic networks in Pennsylvania during 2013 and 2014 provide a unique opportunity for investigating the seismicity of Pennsylvania. These networks, along with several permanent stations in Pennsylvania, resulted in a total of 104 seismometers in and around Pennsylvania that have been used in this study. Event locations were first obtained with Antelope Environmental Monitoring Software using P-wave arrival times. Arrival times were hand picked using a 1-5 Hz bandpass filter to within 0.1 seconds. Events were then relocated using a velocity model developed for Pennsylvania and the HYPOELLIPSE location code. In this study, 1593 seismic events occurred between February 2013 and December 2014 in Pennsylvania. These events ranged between magnitude (ML) 1.04 and 2.89 with an average MLof 1.90. Locations of the events occur across the state in many areas where no seismicity has been previously reported. Preliminary results indicate that most of these events are related to mining activity. Additional work using cross-correlation techniques is underway to examine a number of event clusters for evidence of hydraulic fracturing or wastewater injection sources.

  15. Evidence of Formation of Superdense Nonmagnetic Cobalt

    Science.gov (United States)

    Banu, Nasrin; Singh, Surendra; Satpati, B.; Roy, A.; Basu, S.; Chakraborty, P.; Movva, Hema C. P.; Lauter, V.; Dev, B. N.

    2017-02-01

    Because of the presence of 3d transition metals in the Earth’s core, magnetism of these materials in their dense phases has been a topic of great interest. Theory predicts a dense face-centred-cubic phase of cobalt, which would be nonmagnetic. However, this dense nonmagnetic cobalt has not yet been observed. Recent investigations in thin film polycrystalline materials have shown the formation of compressive stress, which can increase the density of materials. We have discovered the existence of ultrathin superdense nonmagnetic cobalt layers in a polycrystalline cobalt thin film. The densities of these layers are about 1.2–1.4 times the normal density of Co. This has been revealed by X-ray reflectometry experiments, and corroborated by polarized neutron reflectometry (PNR) experiments. Transmission electron microscopy provides further evidence. The magnetic depth profile, obtained by PNR, shows that the superdense Co layers near the top of the film and at the film-substrate interface are nonmagnetic. The major part of the Co film has the usual density and magnetic moment. These results indicate the possibility of existence of nonmagnetic Co in the earth’s core under high pressure.

  16. Evidence for production of single top quarks

    CERN Document Server

    Abazov, V M; Abolins, M; Acharya, B S; Adams, M; Adams, T; Aguiló, E; Ahn, S H; Ahsan, M; Alexeev, G D; Alkhazov, G; Alton, A; Alverson, G; Alves, G A; Anastasoaie, M; Ancu, L S; Andeen, T; Anderson, S; Andrieu, B; Anzelc, M S; Aoki, M; Arnoud, Y; Arov, M; Arthaud, M; Askew, A; sman, B; Assis-Jesus, A C S; Atramentov, O; Avila, C; Ay, C; Badaud, F; Baden, AA; Bagby, L; Baldin, B; Bandurin, D V; Banerjee, P; Banerjee, S; Barberis, E; Barfuss, A F; Bargassa, P; Baringer, P; Barreto, J; Bartlett, J F; Bassler, U; Bauer, D; Beale, S; Bean, A; Begalli, M; Begel, M; Belanger-Champagne, C; Bellantoni, L; Bellavance, A; Benítez, J A; Beri, S B; Bernardi, G; Bernhard, R; Bertram, I; Besançon, M; Beuselinck, R; Bezzubov, V A; Bhat, P C; Bhatnagar, V; Biscarat, C; Blazey, G; Blekman, F; Blessing, S; Bloch, D; Bloom, K; Böhnlein, A; Boline, D; Bolton, T A; Boos, E E; Borissov, G; Bose, T; Brandt, A; Brock, R; Brooijmans, G; Bross, A; Brown, D; Buchanan, N J; Buchholz, D; Bühler, M; Büscher, V; Bunichev, V; Burdin, S; Burke, S; Burnett, T H; Buszello, C P; Butler, J M; Calfayan, P; Calvet, S; Cammin, J; Carvalho, W; Casey, B C K; Castilla-Valdez, H; Chakrabarti, S; Chakraborty, D; Chan, K; Chan, K M; Chandra, A; Charles, F; Cheu, E; Chevallier, F; Cho, D K; Choi, S; Choudhary, B; Christofek, L; Christoudias, T; Cihangir, S; Claes, D; Coadou, Y; Cooke, M; Cooper, W E; Corcoran, M; Couderc, F; Cousinou, M C; Crepe-Renaudin, S; Cutts, D; Cwiok, M; Da Motta, H; Das, A; Davies, G; De, K; De Jong, S J; De La Cruz-Burelo, E; De Oliveira Martins, C; Degenhardt, J D; Dliot, F; Demarteau, M; Demina, R; Denisov, D; Denisov, S P; Desai, S; Diehl, e H T; Diesburg, M; Dominguez, A; Dong, H; Dudko, L V; Duflot, L; Dugad, S R; Duggan, D; Duperrin, A; Dyer, J; Dyshkant, A; Eads, M; Edmunds, D; Ellison, J; Elvira, V D; Enari, Y; Eno, S; Ermolov, P; Evans, H; Evdokimov, A; Evdokimov, V N; Ferapontov, A V; Ferbel, T; Fiedler, F; Filthaut, F; Fisher, W; Fisk, H E; Fortner, M; Fox, H; Fu, S; Fuess, S; Gadfort, T; Galea, C F; Gallas, E; García, C; García-Bellido, A; Gavrilov, V; Gay, P; Geist, W; Gel, D; Gerber, eC E; Gershtein, Yu; Gillberg, D; Ginther, G; Gollub, N; Gmez, B; Goussiou, A; Grannis, P D; Greenlee, o H; Greenwood, Z D; Gregores, E M; Grenier, G; Gris, P; Grivaz, J F; Grohsjean, A; Grünendahl, S; Grünewald, M W; Guo, F; Guo, J; Gutíerrez, G; Gutíerrez, P; Haas, A; Hadley, N J; Haefner, P; Hagopian, S; Haley, J; Hall, I; Hall, R E; Han, L; Harder, K; Harel, A; Harrington, R; Hauptman, J M; Hauser, R; Hays, J; Hebbeker, T; Hedin, D; Hegeman, J G; Heinmiller, J M; Heinson, A P; Heintz, U; Hensel, C; Herner, K; Hesketh, G; Hildreth, M D; Hirosky, R; Hobbs, J D; Hoeneisen, B; Hoeth, H; Hohlfeld, M; Hong, S J; Hossain, S; Houben, P; Hu, Y; Hubacek, Z; Hynek, V; Iashvili, I; Illingworth, R; Ito, A S; Jabeen, S; Jaffré, M; Jain, S; Jakobs, K; Jarvis, C; Jesik, e R; Johns, K; Johnson, C; Johnson, M; Jonckheere, A; Jonsson, P; Juste, A; Kajfasz, E; Kalinin, A M; Kalk, J M; Kappler, S; Karmanov, D; Kasper, P A; Katsanos, I; Kau, D; Kaushik, V; Kehoe, R; Kermiche, S; Khalatyan, N; Khanov, A; Kharchilava, A; Kharzheev, Yu M; Khatidze, D; Kim, T J; Kirby, M H; Kirsch, M; Klima, B; Kohli, J M; Konrath, J P; Korablev, V M; Kozelov, A V; Kraus, J; Krop, D; Kühl, T; Kumar, A; Kupco, A; Kura, T; Kvita, J; Lacroix, F; Lam, cD; Lammers, S; Landsberg, G; Lebrun, P; Lee, W M; Leflat, A; Lellouch, J; Lévêque, J; Li, J; Li, L; Li, Q Z; Lietti, S M; Lima, J G R; Lincoln, D; Linnemann, J; Lipaev, V V; Lipton, R; Liu, Y; Liu, Z; Lobodenko, A; Lokajícek, M; Love, P; Lubatti, H J; Luna, R; Lyon, A L; Maciel, A K A; Mackin, D; Madaras, R J; Mättig, P; Magass, C; Magerkurth, A; Mal, P K; Malbouisson, H B; Malik, S; Malyshev, V L; Mao, H S; Maravin, Y; Martin, B; McCarthy, R; Melnitchouk, A; Mendoza, L; Mercadante, P G; Merkin, M; Merritt, K W; Meyer, A; Meyer, J; Millet, T; Mitrevski, J; Molina, J; Mommsen, R K; Mondal, N K; Moore, R W; Moulik, T; Muanza, G S; Mulders, M; Mulhearn, M; Mundal, O; Mundim, L; Nagy, E; Naimuddin, M; Narain, M; Naumann, N A; Neal, H A; Negret, J P; Neustroev, P; Nilsen, H; Nogima, H; Novaes, S F; Nunnemann, T; O'Dell, V; O'Neil, D C; Obrant, G; Ochando, C; Onoprienko, D; Oshima, N; Osman, N; Osta, J; Otec, R; Oteroy-Garzon, G J; Owen, M; Padley, P; Pangilinan, M; Parashar, N; Park, S J; Park, S K; Parsons, J; Partridge, R; Parua, N; Patwa, A; Pawloski, G; Penning, B; Perfilov, M; Peters, K; Peters, Y; Pétroff, P; Petteni, M; Piegaia, R; Piper, J; Pleier, M A; Podesta-Lerma, P L M; Podstavkov, e V M; Pogorelov, Y; Pol, M E; Polozov, P; Pope, B G; Popov, A V; Potter, C; Prado da Silva, W L; Prosper, H B; Protopopescu, S; Qian, J; Quadt, A; Quinn, B; Rakitine, A; Rangel, M S; Ranjan, K; Ratoff, P N; Renkel, P; Reucroft, S; Rich, P; Rieger, J; Rijssenbeek, M; Ripp-Baudot, I; Rizatdinova, F; Robinson, S; Rodrigues, R F; Rominsky, M; Royon, C; Rubinov, P; Ruchti, R; Safronov, G; Sajot, G; Sánchez-Hernández, A; Sanders, M P; Santoro, A; Savage, G; Sawyer, L; Scanlon, T; Schaile, A D; Schamberger, R D; Scheglov, Y; Schellman, H; Schliephake, T; Schwanenberger, C; Schwartzman, A; Schwienhorst, R; Sekaric, J; Severini, H; Shabalina, E; Shamim, M; Shary, V; Shchukin, A A; Shivpuri, R K; Siccardi, V; Simák, V; Sirotenko, V; Skubic, P; Slattery, P; Smirnov, D; Snow, G R; Snow, J; Snyder, S; Söldner-Rembold, S; Sonnenschein, L; Sopczak, A; Sosebee, M; Soustruznik, K; Spurlock, B; Stark, J; Steele, J; Stolin, V; Stoyanova, D A; Strandberg, J; Strandberg, S; Strang, M A; Strauss, E; Strauss, M; Ströhmer, R; Strom, D; Stutte, L; Sumowidagdo, S; Svoisky, P; Sznajder, A; Tamburello, P; Tanasijczuk, A; Taylor, W; Temple, J; Tiller, B; Tissandier, F; Titov, M; Tokmenin, V V; Toole, T; Torchiani, I; Trefzger, T; Tsybychev, D; Tuchming, B; Tully, C; Tuts, P M; Unalan, R; Uvarov, L; Uvarov, S; Uzunyan, S; Vachon, B; vanden Berg, P J; Van Kooten, R; Van Leeuwen, W M; Varelas, N; Varnes, E W; Vasilyev, I A; Vaupel, M; Verdier, P; Vertogradov, L S; Verzocchi, M; Vetterli, M; Villeneuve-Séguier, F; Vint, P; Vokac, P; Von Törne, E; Voutilainen, M; Wagner, R; Wahl, H D; Wang, L; Wang, M H L S; Warchol, J; Watts, G; Wayne, M; Weber, G; Weber, M; Welty-Rieger, L; Wenger, A; Wermes, N; Wetstein, M; White, A; Wicke, D; Wilson, G W; Wimpenny, S J; Wobisch, M; Wood, D R; Wyatt, T R; Xie, Y; Yacoob, S; Yamada, R; Yan, M; Yasuda, T; Yatsunenko, Y A; Yip, K; Yoo, H D; Youn, S W; Yu, J; Zatserklyaniy, A; Zeitnitz, C; Zhao, T; Zhou, B; Zhu, J; Zielinski, M; Zieminska, D; Zieminski, A; Zivkovic, L; Zutshi, V; Zverev, E G

    2008-01-01

    We present first evidence for the production of single top quarks in the D0 detector at the Fermilab Tevatron ppbar collider. The standard model predicts that the electroweak interaction can produce a top quark together with an antibottom quark or light quark, without the antiparticle top quark partner that is always produced from strong coupling processes. Top quarks were first observed in pair production in 1995, and since then, single top quark production has been searched for in ever larger datasets. In this analysis, we select events from a 0.9 fb-1 dataset that have an electron or muon and missing transverse energy from the decay of a W boson from the top quark decay, and two, three, or four jets, with one or two of the jets identified as originating from a b hadron decay. The selected events are mostly backgrounds such as W+jets and ttbar events, which we separate from the expected signals using three multivariate analysis techniques: boosted decision trees, Bayesian neural networks, and matrix element...

  17. [Evidence-based therapy of Raynaud's syndrome].

    Science.gov (United States)

    Distler, M; Distler, J; Ciurea, A; Kyburz, D; Müller-Ladner, U; Reich, K; Distler, O

    2006-07-01

    Raynaud's syndrome has a prevalence of 3-5% in the general population. Despite its high frequency, the majority of available therapies have not been validated in randomized controlled trials. Effective therapies with a high level of evidence include the calcium channel blocker nifedipine. As analyzed by meta-analyses, nifedipine showed improvement of the peripheral circulation, as well as reduction of both the intensity and frequency of attacks in patients with primary and secondary Raynaud's syndrome as compared to placebo. Similar results in a metaanalysis were obtained for intravenous infusions of iloprost in patients with secondary Raynaud's phenomenon associated with systemic sclerosis. In addition, intravenous infusions of iloprost improved healing of fingertip ulcers in patients with systemic sclerosis. Therapies with significant effects in single randomized controlled trials include angiotensin II-receptor type 1 antagonists (losartan), the calcium channel blockers felodipine und amlodipine, serotonin-reuptake-inhibitors (fluoxetine) und phosphodiesterase-V-inhibitors (sildenafil, vardenafil). However, the results for these promising substances have to be confirmed in long-term trials with larger patient numbers.

  18. Malignant Biliary Obstruction: Evidence for Best Practice

    Science.gov (United States)

    Pu, Leonardo Zorrón Cheng Tao; Singh, Rajvinder; Loong, Cheong Kuan; de Moura, Eduardo Guimarães Hourneaux

    2016-01-01

    What should be done next? Is the stricture benign? Is it resectable? Should I place a stent? Which one? These are some of the questions one ponders when dealing with biliary strictures. In resectable cases, ongoing questions remain as to whether the biliary tree should be drained prior to surgery. In palliative cases, the relief of obstruction remains the main goal. Options for palliative therapy include surgical bypass, percutaneous drainage, and stenting or endoscopic stenting (transpapillary or via an endoscopic ultrasound approach). This review gathers scientific foundations behind these interventions. For operable cases, preoperative biliary drainage should not be performed unless there is evidence of cholangitis, there is delay in surgical intervention, or intense jaundice is present. For inoperable cases, transpapillary stenting after sphincterotomy is preferable over percutaneous drainage. The use of plastic stents (PS) has no benefit over Self-Expandable Metallic Stents (SEMS). In case transpapillary drainage is not possible, Endoscopic Ultrasonography- (EUS-) guided drainage is still an option over percutaneous means. There is no significant difference between the types of SEMS and its indication should be individualized. PMID:26981114

  19. China's Land Market Auctions: Evidence of Corruption?

    Science.gov (United States)

    Cai, Hongbin; Henderson, J Vernon; Zhang, Qinghua

    2013-01-01

    This paper studies the urban land market in China in 2003-2007. In China, all urban land is owned by the state. Leasehold use rights for land for (re)development are sold by city governments and are a key source of city revenue. Leasehold sales are viewed as a major venue for corruption, prompting a number of reforms over the years. Reforms now require all leasehold rights be sold at public auction. There are two main types of auction: regular English auction and an unusual type which we call a "two stage auction". The latter type of auction seems more subject to corruption, and to side deals between potential bidders and the auctioneer. Absent corruption, theory suggests that two stage auctions would most likely maximize sales revenue for properties which are likely to have relatively few bidders, or are "cold", which would suggest negative selection on property unobservables into such auctions. However, if such auctions are more corruptible, that could involve positive selection as city officials divert hotter properties to a more corruptible auction form. The paper finds that, overall, sales prices are lower for two stage auctions, and there is strong evidence of positive selection. The price difference is explained primarily by the fact that two stage auctions typically have just one bidder, or no competition despite the vibrant land market in Chinese cities.

  20. Spirituality in palliative care: Evidence of counselling

    Directory of Open Access Journals (Sweden)

    David Rudilla

    2015-08-01

    Full Text Available When spiritual needs are effectively elaborated, they can help the individual to find meaning, sustain hope, and accept death in the context of the end of life. Counselling has been one of the therapies that is mostused to meet these needs. The aim of this work is to offer evidence on the efficacy of this therapy to improve the spirituality of patients attended in several health devices. In order to achieve this objective, a three-week intervention was carried out with 131 home care and hospitalized patients. The mean age was 70.61 (SD = 11.17; 51.1% were men. Spirituality was assessed before and after the intervention, and a multivariate analysis of variance (MANOVA was used to study the differences between these two moments, together with follow-up ANOVAs. Results indicated a positive effect, with a large effect size, F(3,110 = 31.266, p less than .001, E2 = .460. This study can be the starting point for the implementation of intervention programs in the context of palliative care.

  1. Microspectrophotometric evidence for cone monochromacy in sharks

    Science.gov (United States)

    Hart, Nathan Scott; Theiss, Susan Michelle; Harahush, Blake Kristin; Collin, Shaun Patrick

    2011-03-01

    Sharks are apex predators, and their evolutionary success is in part due to an impressive array of sensory systems, including vision. The eyes of sharks are well developed and function over a wide range of light levels. However, whilst close relatives of the sharks—the rays and chimaeras—are known to have the potential for colour vision, an evolutionary trait thought to provide distinct survival advantages, evidence for colour vision in sharks remains equivocal. Using single-receptor microspectrophotometry, we measured the absorbance spectra of visual pigments located in the retinal photoreceptors of 17 species of shark. We show that, while the spectral tuning of the rod (wavelength of maximum absorbance, λmax 484-518 nm) and cone (λmax 532-561 nm) visual pigments varies between species, each shark has only a single long-wavelength-sensitive cone type. This suggests that sharks may be cone monochromats and, therefore, potentially colour blind. Whilst cone monochromacy on land is rare, it may be a common strategy in the marine environment: many aquatic mammals (whales, dolphins and seals) also possess only a single, green-sensitive cone type. It appears that both sharks and marine mammals may have arrived at the same visual design by convergent evolution. The spectral tuning of the rod and cone pigments of sharks is also discussed in relation to their visual ecology.

  2. [Searching for evidence-based data].

    Science.gov (United States)

    Dufour, J-C; Mancini, J; Fieschi, M

    2009-08-01

    The foundation of evidence-based medicine is critical analysis and synthesis of the best data available concerning a given health problem. These factual data are accessible because of the availability on the Internet of web tools specialized in research for scientific publications. A bibliographic database is a collection of bibliographic references describing the documents indexed. Such a reference includes at least the title, summary (or abstract), a set of keywords, and the type of publication. To conduct a strategically effective search, it is necessary to formulate the question - clinical, diagnostic, prognostic, or related to treatment or prevention - in a form understandable by the research engine. Moreover, it is necessary to choose the specific database or databases, which may have particular specificity, and to analyze the results rapidly to refine the strategy. The search for information is facilitated by the knowledge of the standardized terms commonly used to describe the desired information. These come from a specific thesaurus devoted to document indexing. The most frequently used is MeSH (Medical Subject Heading). The principal bibliographic database whose references include a set of describers from the MeSH thesaurus is Medical Literature Analysis and Retrieval System Online (Medline), which has in turn become a subpart of a still more vast bibliography called PubMed, which indexes an additional 1.4 million references. Numerous other databases are maintained by national or international entities. These include the Cochrane Library, Embase, and the PASCAL and FRANCIS databases.

  3. Shaken baby syndrome: the quest for evidence.

    Science.gov (United States)

    Squier, Waney

    2008-01-01

    Shaken baby syndrome (SBS), characterized by the triad of subdural haemorrhage, retinal haemorrhage, and encephalopathy, was initially based on the hypothesis that shaking causes tearing of bridging veins and bilateral subdural bleeding. It remains controversial. New evidence since SBS was first defined three decades ago needs to be reviewed. Neuropathology shows that most cases do not have traumatic axonal injury, but hypoxic-ischaemic injury and brain swelling. This may allow a lucid interval, which traumatic axonal injury will not. Further, the thin subdural haemorrhages in SBS are unlike the thick unilateral space-occupying clots of trauma. They may not originate from traumatic rupture of bridging veins but from vessels injured by hypoxia and haemodynamic disturbances, as originally proposed by Cushing in 1905. Biomechanical studies have repeatedly failed to show that shaking alone can generate the triad in the absence of significant neck injury. Impact is needed and, indeed, seems to be the cause of the majority of cases of so-called SBS. Birth-related subdural bleeds are much more frequent than previously thought and their potential to cause chronic subdural collections and mimic SBS remains to be established.

  4. Metabolic syndrome: evidences for a personalized nutrition.

    Science.gov (United States)

    Perez-Martinez, Pablo; Garcia-Rios, Antonio; Delgado-Lista, Javier; Perez-Jimenez, Francisco; Lopez-Miranda, Jose

    2012-01-01

    Both insulin resistance and dyslipidaemia are determined by genetic and environmental factors. Depending on their expression and their function, gene variants may influence either insulin action or other metabolic traits. Nutrition also plays an important role in the development and progression of these conditions. Genetic background may interact with habitual dietary fat composition, affecting predisposition to insulin resistance syndrome and individual responsiveness to changes in dietary fat intake. In this context, nutrigenetics has emerged as a multidisciplinary field focusing on studying the interactions between nutritional and genetic factors and health outcomes. Due to the complex nature of gene-environment interactions, however, dietary therapy may require a "personalized" nutrition approach in the future. Although the results have not always been consistent, gene variants that affect primary insulin action, and particularly their interaction with the environment, are important modulators of glucose metabolism. The purpose of this review is to present some evidence of studies that have already demonstrated the significance of gene-nutrient interactions (adiponectin gene, Calpain-10, glucokinase regulatory protein, transcription factor 7-like 2, leptin receptor, scavenger receptor class B type I etc.) that influence insulin resistance in subjects with metabolic syndrome.

  5. EVIDENCE FOR K+ YIELDS P+ VV-.

    Energy Technology Data Exchange (ETDEWEB)

    KETTELL,S.

    1998-12-18

    The first observation of the decay K{sup +} {yields} {pi}{sup +}{nu}{ovr {nu}} has been reported. The E787 experiment presented evidence for the K{sup +} {yields} {pi}{sup +}{nu}{ovr {nu}} decay, based on the observation of a single clean event from data collected during the 1995 run of the AGS (Alternating Gradient Synchrotron at Brookhaven National Laboratory). The branching ratio indicated by this observation, B(K{sup +} {yields} {pi}{sup +}{nu}{ovr {nu}}) = 4.2{sub -3.5}{sup +9.7} x 10{sup -10}, is consistent with the Standard Model expectation although the central experimental value is four times larger. The final E7878 data sample, from the 1995-98 runs, should reach a sensitivity of about five times that of the 1995 run alone. A new experiment, E949, has been given scientific approval and should start data collected in 2001. It is expected to achieve a sensitivity of more than an order of magnitude below the prediction of the Standard Model.

  6. Evidence Based Cataloguing: Moving Beyond the Rules

    Directory of Open Access Journals (Sweden)

    Kathy Carter

    2010-12-01

    Full Text Available Cataloguing is sometimes regarded as a rule-bound, production-based activity that offers little scope for professional judgement and decision-making. In reality, cataloguing involves challenging decisions that can have significant service and financial impacts. The current environment for cataloguing is a maelstrom of changing demands and competing visions for the future. With information-seekers turning en masse to Google and their behaviour receiving greater attention, library vendors are offering “discovery layer” products to replace traditional OPACs, and cataloguers are examining and debating a transformed version of their descriptive cataloguing rules (Resource Description and Access or RDA. In his “Perceptions of the future of cataloging: Is the sky really falling?” (2009, Ivey provides a good summary of this environment. At the same time, myriad new metadata formats and schema are being developed and applied for digital collections in libraries and other institutions. In today’s libraries, cataloguing is no longer limited to management of traditional AACR and MARC-based metadata for traditional library collections. And like their parent institutions, libraries cannot ignore growing pressures to demonstrate accountability and tangible value provided by their services. More than ever, research and an evidence based approach can help guide cataloguing decision-making.

  7. Tourism and Crime: Evidence from the Philippines

    Directory of Open Access Journals (Sweden)

    Rosalina Palanca-Tan

    2015-12-01

    Full Text Available Using panel data gathered from 16 regions of the Philippines for the period 2009–11, this paper investigates the relationship between tourism and crime. The findings of the study show that the relation between tourism and crime may largely depend on the characteristics of visitors and the types of crime. For all types of crime and their aggregate, no significant correlation between the crime rate (defined as the number of crime cases divided by population and total tourist arrivals is found. However, a statistically significant positive relation is found between foreign tourism and robbery and theft cases as well as between overseas Filipino tourism and robbery. On the other hand, domestic tourism is not significantly correlated with any of the four types of crimes. These results, together with a strong evidence of the negative relationship between crime and the crime clearance efficiency, present much opportunity for policy intervention in order to minimize the crime externality of the country’s tourism-led development strategy.

  8. Musculoskeletal injections: a review of the evidence.

    Science.gov (United States)

    Stephens, Mark B; Beutler, Anthony I; O'Connor, Francis G

    2008-10-15

    Injections are valuable procedures for managing musculoskeletal conditions commonly encountered by family physicians. Corticosteroid injections into articular, periarticular, or soft tissue structures relieve pain, reduce inflammation, and improve mobility. Injections can provide diagnostic information and are commonly used for postoperative pain control. Local anesthetics may be injected with corticosteroids to provide additional, rapid pain relief. Steroid injection is the preferred and definitive treatment for de Quervain tenosynovitis and trochanteric bursitis. Steroid injections can also be helpful in controlling pain during physical rehabilitation from rotator cuff syndrome and lateral epicondylitis. Intra-articular steroid injection provides pain relief in rheumatoid arthritis and osteoarthritis. There is little systematic evidence to guide medication selection for therapeutic injections. The medication used and the frequency of injection should be guided by the goal of the injection (i.e., diagnostic or therapeutic), the underlying musculoskeletal diagnosis, and clinical experience. Complications from steroid injections are rare, but physicians should understand the potential risks and counsel patients appropriately. Patients with diabetes who receive periarticular or soft tissue steroid injections should closely monitor their blood glucose for two weeks following injection.

  9. CAN AYURVEDA BE AN EVIDENCE BASED MEDICINE?

    Directory of Open Access Journals (Sweden)

    Bali Yogitha

    2012-04-01

    Full Text Available The concepts of EBM empower us to formulate appropriate clinical questions, appraise the literature using the hierarchy of evidence and apply the study results to their practice. With the ever increasing demands to adopt EBM in practice, healthcare providers require educational resources that present the concepts of the EBM, research methodology and guides to publishing medical research in a simple and easy to understand format. EBM also promotes critical thinking by clinicians. It requires that clinicians have the open-mindedness to look for and try new methods scientifically supported by the literature and it asks the clinical interventions be scrutinized and proven effective. In addition, EBM offers ways to critically evaluate the enormous amount of medical literature for value. In this way, clinical interventions and treatments are not just accepted because someone speaks of their anecdotal effectiveness, but a rigorous standard is applied to scientific data to determine whether the information has merit and applicability. Ayurveda is an Ancient Asian practice. It’s a traditional medical system used by a majority of India’s 1.1 billion populations. Ayurveda is being seen as a rich resource for new drug development by modern day pharmacologists. Ayurveda, the science of life is a branch of Atharvanaveda. It has eight specialized branches such as kayachikitsa (internal medicine, Salakya (ENT, salya tantra (ayurvedic surgery, Agada tantra (toxicology and forensic medicine, bhuta vidya (treatment of psychic diseases, kaumarabhrutya (paediatrics,rasayana tantra (rejuvenation treatments and vajikarana (aphrodisiacs.

  10. Fuzzy Evidence in Identification, Forecasting and Diagnosis

    CERN Document Server

    Rotshtein, Alexander P

    2012-01-01

    The purpose of this book is to present a methodology for designing and tuning fuzzy expert systems in order to identify nonlinear objects; that is, to build input-output models using expert and experimental information. The results of these identifications are used for direct and inverse fuzzy evidence in forecasting and diagnosis problem solving. The book is organised as follows: Chapter 1 presents the basic knowledge about fuzzy sets, genetic algorithms and neural nets necessary for a clear understanding of the rest of this book. Chapter 2 analyzes direct fuzzy inference based on fuzzy if-then rules. Chapter 3 is devoted to the tuning of fuzzy rules for direct inference using genetic algorithms and neural nets. Chapter 4 presents models and algorithms for extracting fuzzy rules from experimental data. Chapter 5 describes a method for solving fuzzy logic equations necessary for the inverse fuzzy inference in diagnostic systems. Chapters 6 and 7 are devoted to inverse fuzzy inference based on fu...

  11. Malignant Biliary Obstruction: Evidence for Best Practice

    Directory of Open Access Journals (Sweden)

    Leonardo Zorrón Cheng Tao Pu

    2016-01-01

    Full Text Available What should be done next? Is the stricture benign? Is it resectable? Should I place a stent? Which one? These are some of the questions one ponders when dealing with biliary strictures. In resectable cases, ongoing questions remain as to whether the biliary tree should be drained prior to surgery. In palliative cases, the relief of obstruction remains the main goal. Options for palliative therapy include surgical bypass, percutaneous drainage, and stenting or endoscopic stenting (transpapillary or via an endoscopic ultrasound approach. This review gathers scientific foundations behind these interventions. For operable cases, preoperative biliary drainage should not be performed unless there is evidence of cholangitis, there is delay in surgical intervention, or intense jaundice is present. For inoperable cases, transpapillary stenting after sphincterotomy is preferable over percutaneous drainage. The use of plastic stents (PS has no benefit over Self-Expandable Metallic Stents (SEMS. In case transpapillary drainage is not possible, Endoscopic Ultrasonography- (EUS- guided drainage is still an option over percutaneous means. There is no significant difference between the types of SEMS and its indication should be individualized.

  12. Subjective evidence based ethnography: method and applications.

    Science.gov (United States)

    Lahlou, Saadi; Le Bellu, Sophie; Boesen-Mariani, Sabine

    2015-06-01

    Subjective Evidence Based Ethnography (SEBE) is a method designed to access subjective experience. It uses First Person Perspective (FPP) digital recordings as a basis for analytic Replay Interviews (RIW) with the participants. This triggers their memory and enables a detailed step by step understanding of activity: goals, subgoals, determinants of actions, decision-making processes, etc. This paper describes the technique and two applications. First, the analysis of professional practices for know-how transferring purposes in industry is illustrated with the analysis of nuclear power-plant operators' gestures. This shows how SEBE enables modelling activity, describing good and bad practices, risky situations, and expert tacit knowledge. Second, the analysis of full days lived by Polish mothers taking care of their children is described, with a specific focus on how they manage their eating and drinking. This research has been done on a sub-sample of a large scale intervention designed to increase plain water drinking vs sweet beverages. It illustrates the interest of SEBE as an exploratory technique in complement to other more classic approaches such as questionnaires and behavioural diaries. It provides the detailed "how" of the effects that are measured at aggregate level by other techniques.

  13. Evidence for a subsurface ocean on Europa

    Science.gov (United States)

    Carr, M.H.; Belton, M.J.S.; Chapman, C.R.; Davies, M.E.; Geissler, P.; Greenberg, R.; McEwen, A.S.; Tufts, B.R.; Greeley, R.; Sullivan, R.; Head, J.W.; Pappalardo, R.T.; Klaasen, K.P.; Johnson, T.V.; Kaufman, J.; Senske, D.; Moore, J.; Neukum, G.; Schubert, G.; Burns, J.A.; Thomas, P.; Veverka, J.

    1998-01-01

    Ground-based spectroscopy of Jupiter's moon Europa, combined with gravity data, suggests that the satellite has an icy crust roughly 150 km thick and a rocky interior. In addition, images obtained by the Voyager spacecraft revealed that Europa's surface is crossed by numerous intersecting ridges and dark bands (called lineae) and is sparsely cratered, indicating that the terrain is probably significantly younger than that of Ganymede and Callisto. It has been suggested that Europa's thin outer ice shell might be separated from the moon's silicate interior by a liquid water layer, delayed or prevented from freezing by tidal heating; in this model, the lineae could be explained by repetitive tidal deformation of the outer ice shell. However, observational confirmation of a subsurface ocean was largely frustrated by the low resolution (>2 km per pixel) of the Voyager images. Here we present high-resolution (54 m per pixel) Galileo spacecraft images of Europa, in which we find evidence for mobile 'icebergs'. The detailed morphology of the terrain strongly supports the presence of liquid water at shallow depths below the surface, either today or at some time in the past. Moreover, lower- resolution observations of much larger regions suggest that the phenomena reported here are widespread.

  14. Evidence for Λc(2593)+ production

    Science.gov (United States)

    Albrecht, H.; Hamacher, T.; Hofmann, R. P.; Kirchhoff, T.; Mankel, R.; Nau, A.; Nowak, S.; Reßing, D.; Schröder, H.; Schulz, H. D.; Walter, M.; Wurth, R.; Hast, C.; Kapitza, H.; Kolanoski, H.; Kosche, A.; Lange, A.; Lindner, A.; Schieber, M.; Siegmund, T.; Thurn, H.; Töpfer, D.; Wegener, D.; Frankl, C.; Graf, J.; Schmidtler, M.; Schramm, M.; Schubert, K. R.; Schwierz, R.; Spaan, B.; Waldi, R.; Reim, K.; Wegener, H.; Eckmann, R.; Kuipers, H.; Mai, O.; Mundt, R.; Oest, T.; Reiner, R.; Rohde, A.; Schmidt-Parzefall, W.; Stiewe, J.; Werner, S.; Ehret, K.; Hofmann, W.; Hüpper, A.; Knöpfle, K. T.; Spengler, J.; Krieger, P.; Macfarlane, D. B.; Prentice, J. D.; Saull, P. R. B.; Tzamariudaki, K.; van de Water, R. G.; Yoon, T.-S.; Schneider, M.; Weseler, S.; Bračko, M.; Kernel, G.; Križan, P.; Križnič, E.; Medin, G.; Podobnik, T.; Živko, T.; Balagura, V.; Barsuk, S.; Belyaev, I.; Chistov, R.; Danilov, M.; Eiges, V.; Gershtein, L.; Gershtein, Yu.; Golutvin, A.; Igonkina, O.; Korolko, I.; Kostina, G.; Litvintsev, D.; Pakhlov, P.; Semenov, S.; Snizhko, A.; Tichomirov, I.; Zaitsev, Yu.

    1997-02-01

    Using the ARGUS detector at the e+e- storage ring DORIS II at DESY, we have found evidence for the production of the excited charmed baryon state Λc(2593)+ in the channel Λ+cπ+π-. Its mass was determined to be (2594.6 +/- 0.9 +/- 0.4) MeV/c2, and the natural width measured to be Γ = (2.9+2.9+1.8-2.1-1.4) MeV. The production cross section times the branching ratios of σ(e+e- -> Λc(2593)+X) × Br (Λc(2593)+ -> Λ+cπ+π-) × Br (Λ+c -> pK- π+) was measured to be (0.25+0.24-0.13 +/- 0.13) pb. The fractions of Λc(2593)+ decays proceeding through the Σ0cπ+ and Σ++cπ- channels were determined to be 0.29 +/- 0.10 +/- 0.11 and 0.37 +/- 0.12 +/- 0.13, respectively.

  15. Evidence for Bulk Ripplocations in Layered Solids

    Science.gov (United States)

    Gruber, Jacob; Lang, Andrew C.; Griggs, Justin; Taheri, Mitra L.; Tucker, Garritt J.; Barsoum, Michel W.

    2016-09-01

    Plastically anisotropic/layered solids are ubiquitous in nature and understanding how they deform is crucial in geology, nuclear engineering, microelectronics, among other fields. Recently, a new defect termed a ripplocation–best described as an atomic scale ripple–was proposed to explain deformation in two-dimensional solids. Herein, we leverage atomistic simulations of graphite to extend the ripplocation idea to bulk layered solids, and confirm that it is essentially a buckling phenomenon. In contrast to dislocations, bulk ripplocations have no Burgers vector and no polarity. In graphite, ripplocations are attracted to other ripplocations, both within the same, and on adjacent layers, the latter resulting in kink boundaries. Furthermore, we present transmission electron microscopy evidence consistent with the existence of bulk ripplocations in Ti3SiC2. Ripplocations are a topological imperative, as they allow atomic layers to glide relative to each other without breaking the in-plane bonds. A more complete understanding of their mechanics and behavior is critically important, and could profoundly influence our current understanding of how graphite, layered silicates, the MAX phases, and many other plastically anisotropic/layered solids, deform and accommodate strain.

  16. Microspectrophotometric evidence for cone monochromacy in sharks.

    Science.gov (United States)

    Hart, Nathan Scott; Theiss, Susan Michelle; Harahush, Blake Kristin; Collin, Shaun Patrick

    2011-03-01

    Sharks are apex predators, and their evolutionary success is in part due to an impressive array of sensory systems, including vision. The eyes of sharks are well developed and function over a wide range of light levels. However, whilst close relatives of the sharks-the rays and chimaeras-are known to have the potential for colour vision, an evolutionary trait thought to provide distinct survival advantages, evidence for colour vision in sharks remains equivocal. Using single-receptor microspectrophotometry, we measured the absorbance spectra of visual pigments located in the retinal photoreceptors of 17 species of shark. We show that, while the spectral tuning of the rod (wavelength of maximum absorbance, λ(max) 484-518 nm) and cone (λ(max) 532-561 nm) visual pigments varies between species, each shark has only a single long-wavelength-sensitive cone type. This suggests that sharks may be cone monochromats and, therefore, potentially colour blind. Whilst cone monochromacy on land is rare, it may be a common strategy in the marine environment: many aquatic mammals (whales, dolphins and seals) also possess only a single, green-sensitive cone type. It appears that both sharks and marine mammals may have arrived at the same visual design by convergent evolution. The spectral tuning of the rod and cone pigments of sharks is also discussed in relation to their visual ecology.

  17. Evidence of Inbreeding in Hodgkin Lymphoma.

    Directory of Open Access Journals (Sweden)

    Hauke Thomsen

    Full Text Available Genome-wide association studies (GWASs have identified several, mainly co-dominantly acting, single-nucleotide polymorphisms (SNPs associated with Hodgkin lymphoma (HL. We searched for recessively acting disease loci by performing an analysis of runs of homozygosity (ROH based on windows of homozygous SNP-blocks and by calculating genomic inbreeding coefficients on a SNP-wise basis. We used data from a previous GWAS with 906 cases and 1217 controls from a population with a long history of no matings between relatives. Ten recurrent ROHs were identified among 25 055 ROHs across all individuals but their association with HL was not genome-wide significant. All recurrent ROHs showed significant evidence for natural selection. As a novel finding genomic inbreeding among cases was significantly higher than among controls (P = 2.11*10-14 even after correcting for covariates. Higher inbreeding among the cases was mainly based on a group of individuals with a higher average length of ROHs per person. This result suggests a correlation of higher levels of inbreeding with higher cancer incidence and might reflect the existence of recessive alleles causing HL. Genomic inbreeding may result in a higher expression of deleterious recessive genes within a population.

  18. [Soya isoflavones and evidences on cardiovascular protection].

    Science.gov (United States)

    González Cañete, Natalia; Durán Agüero, Samuel

    2014-06-01

    Soya isoflavones represent a group of non-nutritive, bioactive compounds, of non-steroidal phenolic nature that are present in soy bean and derived foods. They share with other compounds the capacity of binding to estrogenic receptors from different cells and tissues so that they may act as phytoestrogens. The current interest in these compounds comes from the knowledge that in Asian populations with high levels of their consumption the prevalence of cancer and cardiovascular disease is lower, as compared to the Western countries populations. This cardiovascular benefit would be the result not only of the modulation of plasma lipids, which is a widely studied mechanism. This paper reviews the published evidence about the beneficial effects of soya isoflavones and the different mechanisms of action that would benefit cardiovascular health and that surpass the mechanisms traditionally approached such as the modulation of plasma lipids, and that implicate the regulation of cellular and enzymatic functions in situations such as inflammation, thrombosis, and atherosclerotic progression.

  19. Experimental evidence for foraminiferal calcification under anoxia

    Directory of Open Access Journals (Sweden)

    M. P. Nardelli

    2014-03-01

    Full Text Available Benthic foraminiferal tests are widely used for paleoceanographic reconstructions. There is ample evidence that foraminifera can live in anoxic sediments. For some species, this is explained by a switch to facultative anaerobic metabolism (i.e. denitrification. Here we show for the first time that adult specimens of three benthic foraminiferal species are not only able to survive but are also able to calcify in anoxic conditions, at various depths in the sediment, with and without nitrates. This demonstrates ongoing metabolic processes, even in micro-environments where denitrification is not possible. Earlier observations suggest that the disappearance of foraminiferal communities after prolonged anoxia is not due to instantaneous or strongly increased adult mortality. Here we show that it cannot be explained by an inhibition of growth through chamber addition either. Our observations of ongoing calcification under anoxic conditions means that geochemical proxy data obtained from benthic foraminifera in settings experiencing intermittent anoxia have to be reconsidered. The analysis of whole single specimens or of their successive chambers may provide essential information about short-term environmental variability and/or the causes of anoxia.

  20. Evidence on conservative clinical treatments for haemorrhoids

    Directory of Open Access Journals (Sweden)

    Fernanda da Silva Barbosa

    2013-12-01

    Full Text Available Objective: The objective of this health technology assessment was to analyse the evidence on conservative clinical treatments for haemorrhoids usable in Primary Health Care. Methods: We searched in Embase, LILACS and MEDLINE through Pubmed for meta-analyses, systematic reviews and randomized controlled trials published until December 2012, without limits of language. Studies should evaluate the effects of conservative medical treatments (fibres or laxatives, flavonoids, analgesics, corticosteroids, sitz baths or nitro-glycerine ointments compared to placebo or each other. The outcomes considered were overall symptom improvement, bleeding, itching, pain, prolapse and adverse effects. Results: One meta-analysis showed that fibres promote overall improvement of symptoms and bleeding; and decrease recurrence after outpatient procedures. Three meta-analyses showed efficacy of flavonoids for acute and postoperative bleeding, overall symptom improvement, perianal discharge and recurrence after acute episode. There was no statistical difference for itching, pain, prolapse, or adverse effects in both cases. Rutosides, a type of flavonoid, reduced symptoms in pregnant women, despite the insufficiency of data to prove its safety. No studies were found on other types of treatment that met the selection criteria. Conclusions: In Primary Health Care, oral fibres or flavonoids can be used to improve overall symptoms and bleeding in haemorrhoid patients at grades I and II; to patient grade III who does not wish to undergo outpatient procedure; and postoperatively. Randomized controlled trials with adequate methodological quality are needed to confirm these results.

  1. Valerian: No Evidence for Clinically Relevant Interactions

    Directory of Open Access Journals (Sweden)

    Olaf Kelber

    2014-01-01

    Full Text Available In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs. This questions its use as a safe replacement for, for example, benzodiazepines. A review on the interaction potential of preparations from valerian root (Valeriana officinalis L. root was therefore conducted. A data base search and search in a clinical drug interaction data base were conducted. Thereafter, a systematic assessment of publications was performed. Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified. However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions. In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4. Available animal and human pharmacodynamic studies did not verify any interaction potential. The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance. We conclude that there is no specific evidence questioning their safety, also in cancer patients.

  2. Criminal Evidence : Democracy, Relevance to the Implementation of Accusatory System and Efficiency of the Oral Evidence

    OpenAIRE

    Domingues, Ricardo Alves; Avila, Gustavo Noronha de

    2016-01-01

    The so-called principle of real truth is argument to justify arbitrary procedures used in criminal proceedings. A perfect reproduction of the scene of a crime is impossible. The production of evidence in democratic societies must be guided by the adversarial system . However, not enough positivization affections precepts to this systematic procedure. It is necessary that the practice of instruction acts reveal democratic conduct by the authorities responsible for conducting the process. Only ...

  3. Claiming Evidence from Non-evidence: A Reply to Morton and Harper

    OpenAIRE

    Bialystok, Ellen

    2009-01-01

    Morton and Harper (2007) argue that research presented in support of a bilingual advantage in the development of executive control has been confounded with social class, the actual mechanism for group differences. As evidence, they report a study in which a small group of monolingual and bilingual 6- and 7-year olds performed similarly on a Simon task. The present paper points to weaknesses in their experimental design, analysis, and logic that together undermine their criticism of the conclu...

  4. Clinical Evidence: a useful tool for promoting evidence-based practice?

    Directory of Open Access Journals (Sweden)

    Addis Antonio

    2003-12-01

    Full Text Available Abstract Background Research has shown that many healthcare professionals have problems with guidelines as they would prefer to be given all relevent information relevent to decision-making rather than being told what they should do. This study assesses doctors' judgement of the validity, relevance, clarity and usability of the Italian translation of Clinical Evidence (CE after its free distribution launched by the Italian Ministry of Health Methods Opinions elicited using a standardised questionnaire delivered either by mail or during educational or professional meetings Results Twenty percent (n = 1350 doctors participated the study. Most of them found CE's content valid, useful and relevant for their clinical practice, and said CE can foster communications among clinicians, particularly among GPs and specialists. Hospital doctors (63% more often than GPs (48% read the detailed presentation of individual chapters. Twenty-nine percent said CE brought changes in their clinical practice. Doctors appreciated CE's nature of an evidence-based information compendium and would have not preferred a collection of practice guidelines. Conclusions Overall, the pilot initiative launched by the Italian Ministry of Health seems to have been well received and to support the subsequent decision to make the Italian edition of Clinical Evidence concise available to all doctors practising in the country. Local implementation initiatives should be warranted to favour doctor's use of CE.

  5. Sharing evidence of sustainable land management impacts

    Science.gov (United States)

    Schwilch, Gudrun; Mekdaschi Studer, Rima; Providoli, Isabelle; Liniger, Hanspeter

    2015-04-01

    Ensuring sustainable use of natural resources is crucial for maintaining the basis for our livelihoods. With threats from climate change, disputes over water, biodiversity loss, competing claims on land, and migration increasing worldwide, the demands for sustainable land management (SLM) practices will only increase in the future. For years already, various national and international organizations (GOs, NGOs, donors, research institutes, etc.) have been working on alternative forms of land management. And numerous land users worldwide - especially small farmers - have been testing, adapting, and refining new and better ways of managing land. All too often, however, the resulting SLM knowledge has not been sufficiently evaluated, documented and shared. Among other things, this has often prevented valuable SLM knowledge from being channelled into evidence-based decision-making processes. Indeed, proper knowledge management is crucial for SLM to reach its full potential. Since more than 20 years, the international WOCAT network documents and promotes SLM through its global platform. As a whole, the WOCAT methodology comprises tools for documenting, evaluating, and assessing the impact of SLM practices, as well as for knowledge sharing, analysis and use for decision support in the field, at the planning level, and in scaling up identified good practices. In early 2014, WOCAT's growth and ongoing improvement culminated in its being officially recognized by the UNCCD as the primary recommended database for SLM best practices. Over the years, the WOCAT network confirmed that SLM helps to prevent desertification, to increase biodiversity, enhance food security and to make people less vulnerable to the effects of climate variability and change. In addition, it plays an important role in mitigating climate change through improving soil organic matter and increasing vegetation cover. In-depth assessments of SLM practices from desertification sites enabled an evaluation of

  6. CARTELIZATION AS EQUILIBRIUM? EVIDENCE FROM ROMANIA

    Directory of Open Access Journals (Sweden)

    SILVIU-DAN MATEESCU

    2011-04-01

    Full Text Available This paper discusses the development of the Romanian party system in view of the cartel party thesis proposed by Richard Katz and Peter Mair. The paper is divided into three sections. In the first section I offer a brief review of the cartel party thesis and present a few theoretical arguments regarding the study of cartelization. I argue that Katz and Mair may have overemphasized the importance of cooperation between established parties as necessary for the passing and enactment of cartel related legislation. I hold that the existence of cooperation between established political parties, with or without overt collusion, may be difficult to pinpoint due to the strategic voting that goes on in most legislative bodies. Thus I think it is appropriate to view the passing of the cartel associated legislation as a collective action problem: given high electoral volatility the rules and regulations needed for reducing political uncertainty will be adopted and enacted but not necessarily through cooperation. I suggest that such a perspective can explain every instance when the passing of cartel legislation is dependent on cooperation as well as those instances where no evidence of cooperation can be found. The second section presents some methodological aspects. In the third section I analyze the development of the Romanian party system with emphasis on those electoral rules and regulations that limit open political competition as well as on the system of party finance. I show that electoral rules have gotten progressively harsher and that the system of party finance clearly handicaps new competitors. Moreover the cartel has been extremely successful in keeping new competitors out of Parliament: since the transition from communism to democracy only one genuinely new party has won legislative representation.

  7. Evidence for a Cystic Fibrosis Enteropathy.

    Directory of Open Access Journals (Sweden)

    Marlou P M Adriaanse

    Full Text Available Previous studies have suggested the existence of enteropathy in cystic fibrosis (CF, which may contribute to intestinal function impairment, a poor nutritional status and decline in lung function. This study evaluated enterocyte damage and intestinal inflammation in CF and studied its associations with nutritional status, CF-related morbidities such as impaired lung function and diabetes, and medication use.Sixty-eight CF patients and 107 controls were studied. Levels of serum intestinal-fatty acid binding protein (I-FABP, a specific marker for enterocyte damage, were retrospectively determined. The faecal intestinal inflammation marker calprotectin was prospectively studied. Nutritional status, lung function (FEV1, exocrine pancreatic insufficiency (EPI, CF-related diabetes (CFRD and use of proton pump inhibitors (PPI were obtained from the medical charts.Serum I-FABP levels were elevated in CF patients as compared with controls (p<0.001, and correlated negatively with FEV1 predicted value in children (r-.734, p<0.05. Faecal calprotectin level was elevated in 93% of CF patients, and correlated negatively with FEV1 predicted value in adults (r-.484, p<0.05. No correlation was found between calprotectin levels in faeces and sputum. Faecal calprotectin level was significantly associated with the presence of CFRD, EPI, and PPI use.This study demonstrated enterocyte damage and intestinal inflammation in CF patients, and provides evidence for an inverse correlation between enteropathy and lung function. The presented associations of enteropathy with important CF-related morbidities further emphasize the clinical relevance.

  8. Current clinical evidence on topiramate pharmacokinetics

    Directory of Open Access Journals (Sweden)

    Jakovljević Mihajlo

    2009-01-01

    Full Text Available Topiramate is biochemically classified as a fructopyranose sulphamate. Discovered as early as 1979, during middle 1980's it was approved in many countries for the treatment of epilepsies and migraine prevention. More recently, in the experimental stage, possible new indications have been disclosed: treatment of obesity, bipolar disorder, also cessation of smoking, neuropathic pain, cerebral pseudotumour, bulimia, periventricular leucomalatia in preterm infants and alcohol addiction. Most epileptologists consider it to be the first choice antiepileptic drug in severe pharmacoresistant epilepsies. A substantial corpus of evidence in paediatric population has been accumulated that confirms its efficiency in the treatment of generalised tonic-clonic seizures, Lenox-Gestaut syndrome, partial, absence and combined seizures. Having a unique monosaccharide chemical structure among other anticonvulsant drugs, characterizes it with special pharmacokinetic features. This substance exhibits a low interindividual variability in plasma levels and hence it features predictable pharmacokinetics. A steady state plasma concentration of topiramate increases linearly with higher dosages. Serum protein binding is approximately 15%, and biologic half-life in healthy volunteers is considered to range from 20 to 30 hours. Mean expected distribution volume rates from 0.55-0.8 l/kg, and accordingly, the drug shows a low and saturable binding capacity toward erythrocytes. It has not been present at the market for a sufficiently long time that would enable us to speak about a significant accumulation of data on its metabolism based on post-registration 4th stage clinical trials. For this purpose, we have done a literature review in order to summarise so far reported experience on topiramate pharmacokinetics in patients and healthy adults. Deeper understanding of its pharmacokinetic profile could enable a better technological design of the produced drug and the choice of

  9. Evidence of dopaminergic processing of executive inhibition.

    Directory of Open Access Journals (Sweden)

    Rajendra D Badgaiyan

    Full Text Available Inhibition of unwanted response is an important function of the executive system. Since the inhibitory system is impaired in patients with dysregulated dopamine system, we examined dopamine neurotransmission in the human brain during processing of a task of executive inhibition. The experiment used a recently developed dynamic molecular imaging technique to detect and map dopamine released during performance of a modified Eriksen's flanker task. In this study, young healthy volunteers received an intravenous injection of a dopamine receptor ligand ((11C-raclopride after they were positioned in the PET camera. After the injection, volunteers performed the flanker task under Congruent and Incongruent conditions in a single scan session. They were required to inhibit competing options to select an appropriate response in the Incongruent but not in the Congruent condition. The PET data were dynamically acquired during the experiment and analyzed using two variants of the simplified reference region model. The analysis included estimation of a number of receptor kinetic parameters before and after initiation of the Incongruent condition. We found increase in the rate of ligand displacement (from receptor sites and decrease in the ligand binding potential in the Incongruent condition, suggesting dopamine release during task performance. These changes were observed in small areas of the putamen and caudate bilaterally but were most significant on the dorsal aspect of the body of left caudate. The results provide evidence of dopaminergic processing of executive inhibition and demonstrate that neurochemical changes associated with cognitive processing can be detected and mapped in a single scan session using dynamic molecular imaging.

  10. Biochemical evidence supporting the Cortina criteria.

    Science.gov (United States)

    von Werder, K

    2005-01-01

    Whether acromegaly is inactive or active, respectively cured or not cured depends on the GH suppressibility and the basal IGF-I level. According to the Cortina criteria, GH suppression after oral ingestion of 75 g glucose to acromegaly. According to more recent publications, mortality, which is increased in active acromegaly, is normalized when GH and IGF-I levels have become normal as defined above. Morbidity, i.e. typical features of acromegaly like cardiac problems, carpal tunnel syndrome, carbohydrate intolerance, and excessive sweating may also improve though painful arthropathy, and coarse facial features usually remain unaltered even if the biochemistry has been completely normalized. Using more sensitive GH assays, a group of acromegalic patients was shown to have normal IGF-I levels after surgery, with post-glucose levels of GH 0.14 microg/l, which is the upper level of normal subjects and of a second group of successfully operated acromegalic patients. The latter group also had slightly lower IGF-I levels, though such levels were normal in both groups. Whether this may indicate that these patients who have higher GH levels after oral glucose measured with the more sensitive immunoradiometric assay (IRMA) will more likely develop recurrences remains to be demonstrated in a larger cohort. According to the criteria put forward in Cortina d'Ampezzo in February 1999, all patients who have post-glucose GH levels <1 microg/l and normal age-matched IGF-I levels have to be regarded as well controlled, i.e. sufficiently treated. Because of lack of evidence, there is at present no reason to change the consensus reached there.

  11. 20 CFR 219.33 - Evidence of a deemed valid marriage.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Evidence of a deemed valid marriage. 219.33... EVIDENCE REQUIRED FOR PAYMENT Evidence of Relationship § 219.33 Evidence of a deemed valid marriage. (a) Preferred evidence. Preferred evidence of a deemed valid marriage is— (1) Evidence of a ceremonial...

  12. Remote Upload of Evidence over Mobile Ad Hoc Networks

    Science.gov (United States)

    Ray, Indrajit

    In this work, we report on one aspect of an autonomous robot-based digital evidence acquisition system that we are developing. When forensic investigators operate within a hostile environment they may use remotely operated unmanned devices to gather digital evidence. These systems periodically upload the evidence to a remote central server using a mobile ad hoc network. In such cases, large pieces of information need to be fragmented and transmitted in an appropriate manner. To support proper forensic analysis, certain properties must ensured for each fragment of evidence — confidentiality during communication, authenticity and integrity of the data, and, most importantly, strong evidence of membership for fragments. This paper describes a framework to provide these properties for the robot-based evidence acquisition system under development.

  13. Judges Awareness, Understanding, and Application of Digital Evidence

    Directory of Open Access Journals (Sweden)

    Gary C Kessler

    2011-03-01

    Full Text Available As digital evidence grows in both volume and importance in criminal and civil courts, judges need to fairly and justly evaluate the merits of the offered evidence. To do so, judges need a general understanding of the underlying technologies and applications from which digital evidence is derived. Due to the relative newness of the computer forensics field, there have been few studies on the use of digital forensic evidence and none about judges’ relationship with digital evidence.This paper describes a recent study, using grounded theory methods, into judges’ awareness, knowledge, and perceptions of digital evidence. This study is the first in the U.S. to examine judges and digital forensics, thus opening up a new avenue of research. It is the second time that grounded theory has been employed in a published digital forensics study, demonstrating the applicability of that methodology to this discipline.

  14. Evidence-based dentistry resources for dental practitioners.

    Science.gov (United States)

    Scarbecz, Mark

    2008-01-01

    The American Dental Association has taken an active role in support of an evidence-based approach to the practice of dentistry. This concept integrates clinically relevant scientific evidence into a clinician's decision-making process, along with the patient's oral and medical history, the dentist's own expertise and the patient's treatment needs and preferences. The purpose of this article is to assist dentists in locating and retrieving quality research reports and research evidence which can be integrated into the clinical decision making process. The research methodologies which constitute the foundation of evidence-based dentistry are described. The advantages and disadvantages associated with literature that summarizes research, such as the literature review, the systematic review and meta-analysis are described. Evidence-based resources for dentists are described, such as journals specializing in an evidence-based approach, online resources such as PubMed and the Cochrane Collaboration.

  15. Evaluation of evidence in Occupational Therapy for stroke patients

    DEFF Research Database (Denmark)

    Kristensen, Hanne Kaae; Nygren, C.; Matzen, P.

    2011-01-01

    and the quality evaluated using an evidence taxonomy and an evidence hierarchy. Results: Evidence arose providing support for a client-centred approach, entailing outcome related to better ability to recall goals, the patients feeling more involved and able to manage more everyday life occupations after......Evidence-based practice creates practice that integrates research-driven evidence with clinical expertise and patients’ preferences in clinical decision-making. Aim: The aim of this study was to investigate and evaluate the quality and applicability of scientific research in occupational therapy...... rehabilitation. There is also considerable evidence for the use of everyday life occupations in occupational therapy. Occupational therapy was evaluated as an important aspect of stroke rehabilitation improving outcomes in everyday life occupations including activities of daily living (ADL) and participation...

  16. Insuring against loss of evidence in game-theoretic probability

    CERN Document Server

    Dawid, A Philip; Shafer, Glenn; Shen, Alexander; Vereshchagin, Nikolai; Vovk, Vladimir

    2010-01-01

    We consider the game-theoretic scenario of testing the performance of Forecaster by Sceptic who gambles against the forecasts. Sceptic's current capital is interpreted as the amount of evidence he has found against Forecaster. Reporting the maximum of Sceptic's capital so far exaggerates the evidence. We characterize the set of all increasing functions that remove the exaggeration. This result can be used for insuring against loss of evidence.

  17. Strategic disclosure of evidence : perspectives from psychology and law

    OpenAIRE

    Sukumar, Divya; Wade, Kimberley A.; Hodgson, Jacqueline

    2016-01-01

    The police frequently present their evidence to suspects in investigative interviews. Accordingly, psychologists have developed strategic ways in which the police may present evidence to catch suspects lying or to elicit more information from suspects. While research in psychology continues to illustrate the effectiveness of strategic evidence disclosure tactics in lie detection, lawyers and legal research challenge these very tactics as undermining fair trial defense rights. Legal research i...

  18. Creating an organizational culture for evidence-informed decision making.

    Science.gov (United States)

    Ward, Megan; Mowat, David

    2012-01-01

    A public health department in Ontario, Canada, set a 10-year strategic direction for evidence-informed decision making, defined as the systematic application of research evidence to program decisions. The multifaceted approach has identified eight key lessons for leadership, funding, infrastructure, staff development, partnerships, and change management. Results after 4 years include systematic and transparent application of research to > 15 program decisions and, increasingly, evidence-informed decision making as a cultural norm.

  19. Evidence Based Nursing. A new perspective for Greek Nursing

    Directory of Open Access Journals (Sweden)

    Christina Ouzouni

    2008-07-01

    Full Text Available Despite the fact that nursing research has been developed in Greece, nevertheless the provision of nursing care is not based on current research findings, but rather on the knowledge gained by nurses during their undergraduate education. The transition of medicine in the last decade towards evidence based practice had definitely an impact on the nursing profession.The aim of this article is to briefly present evidence based nursing as a process and perspective to Greek nurses.Method: A literature search was performed in order to identify and review relevant articles concerning evidence based nursing.Conclusions: It has been supported that in the practice of evidence based nursing, a nurse has to decide whether the evidence is relevant for the individual patient. The incorporation of clinical expertise should balance the risks and benefits of a possible treatment and take into consideration the patient’s unique clinical circumstances and preferences. The stages to identify evidence for nursing practice follow firstly a question which must be addressed for a particular clinical problem. Then, a literature search is performed in order to access the evidence and critically appraise it and finally the best available evidence that fits into a particular case is utilized. Evidence based nursing bears benefits for patients, nurses and health care services, as well. In the process of implementing evidence based nursing in Greece there are several constraints. Taking these difficulties into consideration and until Greek nurses familiarize themselves with evidence based nursing care, it is necessary to constitute workgroups of nurse researchers aiming at forming clinical guidelines for nursing practice, which will based on the best available evidence.

  20. Constructing a new theory from old ideas and new evidence

    OpenAIRE

    2013-01-01

    A central tenet of constructivist models of conceptual development is that children’s initial conceptual level constrains how they make sense of new evidence and thus whether exposure to evidence will prompt conceptual change. Yet, little experimental evidence directly examines this claim for the case of sustained, fundamental conceptual achievements. The present study combined scaling and experimental microgenetic methods to examine the processes underlying conceptual change in the context o...

  1. Forensic DNA Evidence at a Crime Scene: An Investigator's Commentary.

    Science.gov (United States)

    Blozis, J

    2010-07-01

    The purpose of this article is twofold. The first is to present a law enforcement perspective of the importance of a crime scene, the value of probative evidence, and how to properly recognize, document, and collect evidence. The second purpose is to provide forensic scientists who primarily work in laboratories with the ability to gain insight on how law enforcement personnel process a crime scene. With all the technological advances in the various disciplines associated with forensic science, none have been more spectacular than those in the field of DNA. The development of sophisticated and sensitive instrumentation has led forensic scientists to be able to detect DNA profiles from minute samples of evidence in a much timelier manner. In forensic laboratories, safeguards and protocols associated with ASCLD/LAB International, Forensic Quality Services, and or ISO/IEC 17020:1998 accreditation have been established and implemented to ensure proper case analysis. But no scientist, no instrumentation, and no laboratory could come to a successful conclusion about evidence if that evidence had been compromised or simply missed at a crime scene. Evidence collectors must be trained thoroughly to process a scene and to be able to distinguish between probative evidence and non probative evidence. I am a firm believer of the phrase "garbage in is garbage out." One of the evidence collector's main goals is not only to recover enough DNA so that an eligible CODIS profile can be generated to identify an offender but also, more importantly, to recover sufficient DNA to exonerate the innocent.

  2. Evidence-based dentistry as it relates to dental materials.

    Science.gov (United States)

    Bayne, Stephen C; Fitzgerald, Mark

    2014-01-01

    Evidence-based dentistry (EBD) is reviewed in depth to underscore the limitations for evidence-based dental materials information that exist at this time. Anecdotal estimates of evidence for dental practice are in the range of 8 percent to 10 percent. While the process of evaluating the literature base for dental evidence began 20 years ago, it was not practical to implement it until high-speed wireless connections, open access to journals, and omnipresent connections via smart phones became a reality. EBD includes five stages of information collection and analysis, starting with a careful definition of a clinical question using the PICO(T) approach. Clinical evidence in randomized control trials is considered the best. Clinical trial perspectives (prospective, cross-sectional, retrospective) and outcome designs (RCTs, SCTs, CCTs, cohort studies, case-control studies) are quite varied. Aggregation techniques (including meta-analyses) allow meaningful combinations of clinical data from trials with similar designs but with fewer rigors. Appraisals attempt to assess the entire evidence base without bias and answer clinical questions. Varying intensities to these approaches, Cochrane Collaboration, ADA-EBD Library, UTHSCSA CATs Library, are used to answer questions. Dental materials evidence from clinical trials is infrequent, short-term, and often not compliant with current guidelines (registration, CONSORT, PRISMA). Reports in current evidence libraries indicate less than 5 percent of evidence is related to restorative dental materials.

  3. Evidence-based laboratory medicine: is it working in practice?

    Science.gov (United States)

    Price, Christopher P

    2012-02-01

    The principles of Evidence-Based Medicine have been established for about two decades, with the need for evidence-based clinical practice now being accepted in most health systems around the world. These principles can be employed in laboratory medicine. The key steps in evidence-based practice, namely (i) formulating the question; (ii) searching for evidence; (iii) appraising evidence; (iv) applying evidence; and (v) assessing the experience are all accepted but, as yet, translation into daily clinical and laboratory practice has been slow. Furthermore, the demand for evidence-based laboratory medicine (EBLM) has been slow to develop.There are many contrasting observations about laboratory medicine, for example (i) there is too much testing vs insufficient testing; (ii) testing is expensive vs laboratories are expected to generate income; and (iii) test results have little impact on outcomes vs test results are crucial to clinical decision making. However, there is little evidence to support any of these observations. Integrating the principles of EBLM into routine practice will help to resolve some of these issues by identifying (a) where laboratory medicine fits into the care pathway; (b) where testing is appropriate; (c) the nature and quality of evidence required to demonstrate the clinical utility of a test; (d) how the test result impacts on clinical actions; (e) where changes in the care pathway will occur; and (f) where benefit/value can be achieved. These answers will help to establish the culture of EBLM in clinical and laboratory practice.

  4. A Probabilistic Analysis of the Sacco and Vanzetti Evidence

    CERN Document Server

    Kadane, Joseph B

    2011-01-01

    A Probabilistic Analysis of the Sacco and Vanzetti Evidence is a Bayesian analysis of the trial and post-trial evidence in the Sacco and Vanzetti case, based on subjectively determined probabilities and assumed relationships among evidential events. It applies the ideas of charting evidence and probabilistic assessment to this case, which is perhaps the ranking cause celebre in all of American legal history. Modern computation methods applied to inference networks are used to show how the inferential force of evidence in a complicated case can be graded. The authors employ probabilistic assess

  5. Lost in translation: bibliotherapy and evidence-based medicine.

    Science.gov (United States)

    Dysart-Gale, Deborah

    2008-03-01

    Evidence-based medicine's (EBM) quantitative methodologies reflect medical science's long-standing mistrust of the imprecision and subjectivity of ordinary descriptive language. However, EBM's attempts to replace subjectivity with precise empirical methods are problematic when clinicians must negotiate between scientific medicine and patients' experience. This problem is evident in the case of bibliotherapy (patient reading as treatment modality), a practice widespread despite its reliance on anecdotal evidence. While EBM purports to replace such flawed practice with reliable evidence-based methods, this essay argues that its aversion to subjective language prevents EBM from effectively evaluating bibliotherapy or making it amenable to clinical and research governance.

  6. Cochrane Lecture 1997. What evidence do we need for evidence based medicine?

    Science.gov (United States)

    Hart, J T

    1997-12-01

    As presently understood, evidence based medicine aims to advance practice from its traditional unverifiable mix of art and science to rational use of measurable inputs and outputs. In practice, however, its advocates accept uncritically a desocialised definition of science, assume that major clinical decisions are taken at the level of secondary specialist rather than primary generalist care, and ignore the multiple nature of most clinical problems, as well as the complexity of social problems within which clinical problems arise and have to be solved. These reductionist assumptions derive from the use of evidence based medicine as a tool for managed care in a transactional model for consultations. If these assumptions persist, they will strengthen reification of disease and promote the episodic output of process regardless of health outcome. We need to work within a different paradigm based on development of patients as co-producers rather than consumers, promoting continuing output of health gain through shared decisions using all relevant evidence, within a broader, socialised definition of science. Adoption of this model would require a major social and cultural shift for health professionals. This shift has already begun, promoted by changes in public attitudes to professional authority, changes in the relation of professionals to managers, and pressures for improved effectiveness and efficiency which, contrary to received wisdom, seem more likely to endorse cooperative than transactional clinical production. Progress on these lines is resisted by rapidly growing and extremely powerful economic and political interests. Health professionals and strategists have yet to recognise and admit the existence of this choice.

  7. Evidence for production of single top quarks

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, V.M.; /Dubna, JINR; Abbott, B.; /Oklahoma U.; Abolins, M.; /Michigan State U.; Acharya, B.S.; /Tata Inst.; Adams, M.; /Illinois U., Chicago; Adams, T.; /Florida State U.; Aguilo, E.; /Simon Fraser U.; Ahn, S.H.; /Korea U., KODEL; Ahsan, M.; /Kansas State U.; Alexeev, G.D.; /Dubna, JINR; Alkhazov, G.; /St. Petersburg, INP /Michigan U.

    2008-03-01

    We present first evidence for the production of single top quarks in the D0 detector at the Fermilab Tevatron p{bar p} collider. The standard model predicts that the electroweak interaction can produce a top quark together with an antibottom quark or light quark, without the antiparticle top quark partner that is always produced from strong coupling processes. Top quarks were first observed in pair production in 1995, and since then, single top quark production has been searched for in ever larger datasets. In this analysis, we select events from a 0.9 fb{sup -1} dataset that have an electron or muon and missing transverse energy from the decay of a W boson from the top quark decay, and two, three, or four jets, with one or two of the jets identified as originating from a b hadron decay. The selected events are mostly backgrounds such as W+jets and t{bar t} events, which we separate from the expected signals using three multivariate analysis techniques: boosted decision trees, Bayesian neural networks, and matrix element calculations. A binned likelihood fit of the signal cross section plus background to the data from the combination of the results from the three analysis methods gives a cross section for single top quark production of {sigma}(p{bar p} {yields} tb + X, tqb + X) = 4.7 {+-} 1.3 pb. The probability to measure a cross section at this value or higher in the absence of signal is 0.014%, corresponding to a 3.6 standard deviation significance. The measured cross section value is compatible at the 10% level with the standard model prediction for electroweak top quark production. We use the cross section measurement to directly determine the Cabibbo-Kobayashi-Maskawa quark mixing matrix element that describes the Wtb coupling and find |V{sub tb}f{sub 1}{sup L}| = 1.31{sub -0.21}{sup +0.25}, where f{sub 1}{sup L} is a generic vector coupling. This model-independent measurement translates into 0.68 < |V{sub tb}| {le} 1 at the 95% C.L. in the standard model.

  8. Evidence for production of single top quarks

    Science.gov (United States)

    Abazov, V. M.; Abbott, B.; Abolins, M.; Acharya, B. S.; Adams, M.; Adams, T.; Aguilo, E.; Ahn, S. H.; Ahsan, M.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G. A.; Anastasoaie, M.; Ancu, L. S.; Andeen, T.; Anderson, S.; Anzelc, M. S.; Aoki, M.; Arnoud, Y.; Arov, M.; Arthaud, M.; Askew, A.; Åsman, B.; Assis Jesus, A. C. S.; Atramentov, O.; Avila, C.; Ay, C.; Badaud, F.; Baden, A.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, P.; Banerjee, S.; Barberis, E.; Barfuss, A.-F.; Bargassa, P.; Baringer, P.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bauer, D.; Beale, S.; Bean, A.; Begalli, M.; Begel, M.; Belanger-Champagne, C.; Bellantoni, L.; Bellavance, A.; Benitez, J. A.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bezzubov, V. A.; Bhat, P. C.; Bhatnagar, V.; Biscarat, C.; Blazey, G.; Blekman, F.; Blessing, S.; Bloch, D.; Bloom, K.; Boehnlein, A.; Boline, D.; Bolton, T. A.; Boos, E. E.; Borissov, G.; Bose, T.; Brandt, A.; Brock, R.; Brooijmans, G.; Bross, A.; Brown, D.; Buchanan, N. J.; Buchholz, D.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Burke, S.; Burnett, T. H.; Buszello, C. P.; Butler, J. M.; Calfayan, P.; Calvet, S.; Cammin, J.; Carvalho, W.; Casey, B. C. K.; Castilla-Valdez, H.; Chakrabarti, S.; Chakraborty, D.; Chan, K.; Chan, K. M.; Chandra, A.; Charles, F.; Cheu, E.; Chevallier, F.; Cho, D. K.; Choi, S.; Choudhary, B.; Christofek, L.; Christoudias, T.; Cihangir, S.; Claes, D.; Coadou, Y.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M.-C.; Crépé-Renaudin, S.; Cutts, D.; Ćwiok, M.; da Motta, H.; Das, A.; Davies, G.; de, K.; de Jong, S. J.; de La Cruz-Burelo, E.; de Oliveira Martins, C.; Degenhardt, J. D.; Déliot, F.; Demarteau, M.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Diehl, H. T.; Diesburg, M.; Dominguez, A.; Dong, H.; Dudko, L. V.; Duflot, L.; Dugad, S. R.; Duggan, D.; Duperrin, A.; Dyer, J.; Dyshkant, A.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Eno, S.; Ermolov, P.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Ferapontov, A. V.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fu, S.; Fuess, S.; Gadfort, T.; Galea, C. F.; Gallas, E.; Garcia, C.; Garcia-Bellido, A.; Gavrilov, V.; Gay, P.; Geist, W.; Gelé, D.; Gerber, C. E.; Gershtein, Y.; Gillberg, D.; Ginther, G.; Gollub, N.; Gómez, B.; Goussiou, A.; Grannis, P. D.; Greenlee, H.; Greenwood, Z. D.; Gregores, E. M.; Grenier, G.; Gris, Ph.; Grivaz, J.-F.; Grohsjean, A.; Grünendahl, S.; Grünewald, M. W.; Guo, F.; Guo, J.; Gutierrez, G.; Gutierrez, P.; Haas, A.; Hadley, N. J.; Haefner, P.; Hagopian, S.; Haley, J.; Hall, I.; Hall, R. E.; Han, L.; Harder, K.; Harel, A.; Harrington, R.; Hauptman, J. M.; Hauser, R.; Hays, J.; Hebbeker, T.; Hedin, D.; Hegeman, J. G.; Heinmiller, J. M.; Heinson, A. P.; Heintz, U.; Hensel, C.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hobbs, J. D.; Hoeneisen, B.; Hoeth, H.; Hohlfeld, M.; Hong, S. J.; Hossain, S.; Houben, P.; Hu, Y.; Hubacek, Z.; Hynek, V.; Iashvili, I.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffré, M.; Jain, S.; Jakobs, K.; Jarvis, C.; Jesik, R.; Johns, K.; Johnson, C.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Juste, A.; Kajfasz, E.; Kalinin, A. M.; Kalk, J. M.; Kappler, S.; Karmanov, D.; Kasper, P. A.; Katsanos, I.; Kau, D.; Kaushik, V.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. M.; Khatidze, D.; Kim, T. J.; Kirby, M. H.; Kirsch, M.; Klima, B.; Kohli, J. M.; Konrath, J.-P.; Korablev, V. M.; Kozelov, A. V.; Kraus, J.; Krop, D.; Kuhl, T.; Kumar, A.; Kupco, A.; Kurča, T.; Kvita, J.; Lacroix, F.; Lam, D.; Lammers, S.; Landsberg, G.; Lebrun, P.; Lee, W. M.; Leflat, A.; Lellouch, J.; Leveque, J.; Li, J.; Li, L.; Li, Q. Z.; Lietti, S. M.; Lima, J. G. R.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, Y.; Liu, Z.; Lobodenko, A.; Lokajicek, M.; Love, P.; Lubatti, H. J.; Luna, R.; Lyon, A. L.; Maciel, A. K. A.; Mackin, D.; Madaras, R. J.; Mättig, P.; Magass, C.; Magerkurth, A.; Mal, P. K.; Malbouisson, H. B.; Malik, S.; Malyshev, V. L.; Mao, H. S.; Maravin, Y.; Martin, B.; McCarthy, R.; Melnitchouk, A.; Mendoza, L.; Mercadante, P. G.; Merkin, M.; Merritt, K. W.; Meyer, A.; Meyer, J.; Millet, T.; Mitrevski, J.; Molina, J.; Mommsen, R. K.; Mondal, N. K.; Moore, R. W.; Moulik, T.; Muanza, G. S.; Mulders, M.; Mulhearn, M.; Mundal, O.; Mundim, L.; Nagy, E.; Naimuddin, M.; Narain, M.; Naumann, N. A.; Neal, H. A.; Negret, J. P.; Neustroev, P.; Nilsen, H.; Nogima, H.; Novaes, S. F.; Nunnemann, T.; O'Dell, V.; O'Neil, D. C.; Obrant, G.; Ochando, C.; Onoprienko, D.; Oshima, N.; Osman, N.; Osta, J.; Otec, R.; Otero Y Garzón, G. J.; Owen, M.; Padley, P.; Pangilinan, M.; Parashar, N.; Park, S.-J.; Park, S. K.; Parsons, J.; Partridge, R.; Parua, N.; Patwa, A.; Pawloski, G.; Penning, B.; Perfilov, M.; Peters, K.; Peters, Y.; Pétroff, P.; Petteni, M.; Piegaia, R.; Piper, J.; Pleier, M.-A.; Podesta-Lerma, P. L. M.; Podstavkov, V. M.; Pogorelov, Y.; Pol, M.-E.; Polozov, P.; Pope, B. G.; Popov, A. V.; Potter, C.; Prado da Silva, W. L.; Prosper, H. B.; Protopopescu, S.; Qian, J.; Quadt, A.; Quinn, B.; Rakitine, A.; Rangel, M. S.; Ranjan, K.; Ratoff, P. N.; Renkel, P.; Reucroft, S.; Rich, P.; Rieger, J.; Rijssenbeek, M.; Ripp-Baudot, I.; Rizatdinova, F.; Robinson, S.; Rodrigues, R. F.; Rominsky, M.; Royon, C.; Rubinov, P.; Ruchti, R.; Safronov, G.; Sajot, G.; Sánchez-Hernández, A.; Sanders, M. P.; Santoro, A.; Savage, G.; Sawyer, L.; Scanlon, T.; Schaile, D.; Schamberger, R. D.; Scheglov, Y.; Schellman, H.; Schliephake, T.; Schwanenberger, C.; Schwartzman, A.; Schwienhorst, R.; Sekaric, J.; Severini, H.; Shabalina, E.; Shamim, M.; Shary, V.; Shchukin, A. A.; Shivpuri, R. K.; Siccardi, V.; Simak, V.; Sirotenko, V.; Skubic, P.; Slattery, P.; Smirnov, D.; Snow, G. R.; Snow, J.; Snyder, S.; Söldner-Rembold, S.; Sonnenschein, L.; Sopczak, A.; Sosebee, M.; Soustruznik, K.; Spurlock, B.; Stark, J.; Steele, J.; Stolin, V.; Stoyanova, D. A.; Strandberg, J.; Strandberg, S.; Strang, M. A.; Strauss, E.; Strauss, M.; Ströhmer, R.; Strom, D.; Stutte, L.; Sumowidagdo, S.; Svoisky, P.; Sznajder, A.; Tamburello, P.; Tanasijczuk, A.; Taylor, W.; Temple, J.; Tiller, B.; Tissandier, F.; Titov, M.; Tokmenin, V. V.; Toole, T.; Torchiani, I.; Trefzger, T.; Tsybychev, D.; Tuchming, B.; Tully, C.; Tuts, P. M.; Unalan, R.; Uvarov, L.; Uvarov, S.; Uzunyan, S.; Vachon, B.; van den Berg, P. J.; van Kooten, R.; van Leeuwen, W. M.; Varelas, N.; Varnes, E. W.; Vasilyev, I. A.; Vaupel, M.; Verdier, P.; Vertogradov, L. S.; Verzocchi, M.; Vetterli, M.; Villeneuve-Seguier, F.; Vint, P.; Vokac, P.; von Toerne, E.; Voutilainen, M.; Wagner, R.; Wahl, H. D.; Wang, L.; Wang, M. H. L. S.; Warchol, J.; Watts, G.; Wayne, M.; Weber, G.; Weber, M.; Welty-Rieger, L.; Wenger, A.; Wermes, N.; Wetstein, M.; White, A.; Wicke, D.; Wilson, G. W.; Wimpenny, S. J.; Wobisch, M.; Wood, D. R.; Wyatt, T. R.; Xie, Y.; Yacoob, S.; Yamada, R.; Yan, M.; Yasuda, T.; Yatsunenko, Y. A.; Yip, K.; Yoo, H. D.; Youn, S. W.; Yu, J.; Zatserklyaniy, A.; Zeitnitz, C.; Zhao, T.; Zhou, B.; Zhu, J.; Zielinski, M.; Zieminska, D.; Zieminski, A.; Zivkovic, L.; Zutshi, V.; Zverev, E. G.

    2008-07-01

    We present first evidence for the production of single top quarks in the D0 detector at the Fermilab Tevatron p pmacr collider. The standard model predicts that the electroweak interaction can produce a top quark together with an antibottom quark or light quark, without the antiparticle top-quark partner that is always produced from strong-coupling processes. Top quarks were first observed in pair production in 1995, and since then, single top-quark production has been searched for in ever larger data sets. In this analysis, we select events from a 0.9fb-1 data set that have an electron or muon and missing transverse energy from the decay of a W boson from the top-quark decay, and two, three, or four jets, with one or two of the jets identified as originating from a b hadron decay. The selected events are mostly backgrounds such as W+jets and t tmacr events, which we separate from the expected signals using three multivariate analysis techniques: boosted decision trees, Bayesian neural networks, and matrix-element calculations. A binned likelihood fit of the signal cross section plus background to the data from the combination of the results from the three analysis methods gives a cross section for single top-quark production of σ(p pmacr →tb+X,tqb+X)=4.7±1.3pb. The probability to measure a cross section at this value or higher in the absence of signal is 0.014%, corresponding to a 3.6 standard deviation significance. The measured cross section value is compatible at the 10% level with the standard model prediction for electroweak top-quark production. We use the cross section measurement to directly determine the Cabibbo-Kobayashi-Maskawa quark mixing matrix element that describes the Wtb coupling and find |Vtbf1L|=1.31-0.21+0.25, where f1L is a generic vector coupling. This model-independent measurement translates into 0.68<|Vtb|≤1 at the 95% C.L. in the standard model.

  9. Biomarker evidence for Archean oxygen fluxes (Invited)

    Science.gov (United States)

    Hallmann, C.; Waldbauer, J.; Sherman, L. S.; Summons, R. E.

    2010-12-01

    Knowledge of deep-time organismic diversity may be gained from the study of preserved sedimentary lipids with taxonomic specificity, i.e. biomarker hydrocarbons (e.g. Brocks and Summons, 2003; Waldbauer et al., 2009). As a consequence of long residence times and high thermal maturities however, biomarker concentrations are extremely low in most ancient (Precambrian) sediment samples, making them exceptionally prone to contamination during drilling, sampling and laboratory workup (e.g. Brocks et al., 2008). Outcrop samples most always carry a modern overprint and deep-time biogeochemistry thus relies on drilling operations to retrieve ‘clean’ sediment cores. One such effort was initiated by NASA’s Astrobiology Institute (NAI): the Archean biosphere drilling project (ABDP). We here report on the lipids retrieved from sediment samples in drill hole ABDP-9. Strong heterogeneities of extractable organic matter - both on a spatial scale and in free- vs. mineral-occluded bitumen - provide us with an opportunity to distinguish indigenous lipids from contaminants introduced during drilling. Stratigraphic trends in biomarker data for mineral-occluded bitumens are complementary to previously reported data (e.g. S- and N-isotopes, molybdenum enrichments) from ABDP-9 sediments (Anbar et al., 2007; Kaufman et al., 2007; Garvin et al., 2009) and suggest periodic fluxes of oxygen before the great oxidation event. Anbar et al. A whiff of oxygen before the great oxidation event. Science 317 (2007), 1903-1906. Brocks & Summons. Sedimentary hydrocarbons, biomarkers for early life. In: Schlesinger (Ed.) Treatise on Geochemistry, Vol. 8 (2003), 63-115. Brocks et al. Assessing biomarker syngeneity using branched alkanes with quaternary carbon (BAQCs) and other plastic contaminants. Geochimica et Cosmochimica Acta 72 (2008), 871-888. Garvin et al. Isotopic evidence for a aerobic nitrogen cycle in the latest Archean. Science 323 (2009), 1045-1048. Kaufman et al. Late Archean

  10. Paleoecology of Easter Island: Evidence and uncertainties

    Science.gov (United States)

    Rull, V.; Cañellas-Boltà, N.; Sáez, A.; Giralt, S.; Pla, S.; Margalef, O.

    2010-04-01

    The existence of palm-dominated forests covering the island since the last glaciation and the recent deforestation by humans are paradigmatic in Easter Island's paleoecological reconstructions. The timing and mode of the deforestation are controversial, but there is general agreement that it actually occurred, and it is often given as an example of a human-induced environmental catastrophe with philosophical implications for the future of the whole planet. To evaluate whether this is the only well-supported hypothesis or if there might be other scenarios compatible with the paleoecological data, this paper reviews all the available evidence on past vegetation changes on Easter Island. The discussion is centered on three main points: 1) the alleged nature and extension of the former forests, 2) the taxonomic identity of the dominant palms, and 3) the nature of the recent ecological changes leading to a treeless island. The potential causes of the assumed deforestation are beyond the scope of this study. Concerning the first point, palynological and anthracological results obtained so far are not only compatible with a forested island, but also with other scenarios, for example a mosaic vegetation pattern with forests restricted to sites with a high freshwater table (gallery forests), which are mostly around the permanent lakes and along the coasts. With regard to palm identity, some extant species have been proposed as potential candidates, but the palms that dominated these forests seem to have become extinct and their identity remains unknown. The existence of a sedimentary hiatus around the dates of forest decline complicates the picture and reinforces the possibility of climatic changes. It is concluded that the hypothesis of a previously forested island has yet to be demonstrated. Therefore, the recent ecological disaster, human-induced or not, is still speculative. Several types of future studies are proposed for a better understanding of Easter Island

  11. Quick evidence reviews using Epistemonikos: a thorough, friendly and current approach to evidence in health

    Directory of Open Access Journals (Sweden)

    Gabriel Rada

    2014-07-01

    Full Text Available Those who make decisions on healthcare should do so informed by the best scientific evidence at one’s disposal. During the last few years, it has become undeniable that identifying and synthesizing all scientific studies that respond a question constitutes an unapproachable challenge for a clinician. The quantity of information has increased excessively, some facts are not available, investigations are of either bad quality or even fraudulent, and the methods for achieving a combination and synthesis of all studies are each time more sophisticated. Moreover, if this inaccurate process is carried out, there exists a high risk of arriving at a biased conclusion.

  12. Invasive candidiasis in the ICU: evidence based and on the edge of evidence.

    Science.gov (United States)

    Hollenbach, Eike

    2008-09-01

    Invasive candidiasis is a common nosocomial infection among critically ill patients, constitutes an important cause of sepsis, and is associated with significant morbidity and mortality. The Infectious Diseases Society of America (IDSA) has created evidence-based guidelines for the management of invasive candidiasis. However, several new antifungal agents with excellent activity against Candida spp. and favourable safety profiles have been introduced successfully in the clinical setting since the IDSA guidelines were published in late 2003. Further, the role of antifungals is not entirely clear in the intensive care unit (ICU) setting. Therefore, this article discusses daily problems in the prophylaxis and treatment of invasive candidasis in interdisciplinary ICUs.

  13. Integrating evidence-based perfusion into practices: the International Consortium for Evidence-Based Perfusion.

    Science.gov (United States)

    Likosky, Donald S

    2006-12-01

    There is surmounting pressure for clinicians domestically and abroad not only to practice evidence-based perfusion, but also to supplement practice with documentation thereof. In this editorial, I shall describe an international initiative aimed at embracing this dictum from patients, regulatory bodies, and payers. "Research is the only hope that the future will be different than the past"- Daniel Mintz, MD "Practical men who believe themselves to be quite exempt from any intellectual influences are usually the slaves of some defunct economist.... It is ideas not vested interests which are dangerous for good or evil."-John Maynard Keynes.

  14. Is evidence-based medicine so evident in veterinary research and practice? History, obstacles and perspectives.

    Science.gov (United States)

    Vandeweerd, Jean-Michel; Kirschvink, Nathalie; Clegg, Peter; Vandenput, Sandrine; Gustin, Pascal; Saegerman, Claude

    2012-01-01

    Evidence-based medicine (EBM) refers to the conscientious, explicit and judicious use of current best evidence from research for the care of an individual patient. The concept of EBM was first described in human medicine in the early 1990s and was introduced to veterinary medicine 10 years later. However, it is not clear that the EBM approach promulgated in human medicine can be applied to the same extent to veterinary medicine. EBM has the potential to help veterinarians to make more informed decisions, but obstacles to the implementation of EBM include a lack of high quality patient-centred research, the need for basic understanding of clinical epidemiology by veterinarians, the absence of adequate searching techniques and accessibility to scientific data bases and the inadequacy of EBM tools that can be applied to the busy daily practise of veterinarians. This review describes the development of EBM in the veterinary profession, identifies its advantages and disadvantages and discusses whether and how veterinary surgeons should further adopt the EBM approach of human medicine.

  15. Psicanálise baseada em evidências? Evidence-based psychoanalysis?

    Directory of Open Access Journals (Sweden)

    Liana Albernaz de Melo Bastos

    2002-12-01

    Full Text Available A partir da discussão sobre a eficácia da psicanálise, a autora considera necessário o diálogo com as neurociências e a psicofarmacologia. Aponta como o critério de eficácia, entendido pela medicina baseada em evidências, apaga a dimensão da narratividade e, conseqüentemente, da subjetividade. Apresenta uma vinheta de um atendimento emergencial no Hospital Universitário Clementino Fraga Filho como possibilidade de se manter a escuta psicanalítica no atendimento psiquiátrico.Based on the discussion concerning the efficacy of psychoanalysis, the author considers the need to engage in dialogue with the neurosciences and psychopharmacology. She indicates how the criterion of efficacy, as defined by evidence-based medicine, erases the dimension of the narrative and consequently that of subjectivity. She presents as a vignette an emergency case at the Clementino Fraga Filho University Hospital in Rio de Janeiro, illustrating the possibility of maintaining psychoanalytic listening in psychiatric treatment.

  16. 38 CFR 3.204 - Evidence of dependents and age.

    Science.gov (United States)

    2010-07-01

    ... name and relationship of the other person to the claimant; and, where the claimant's dependent child... question of its validity; the claimant's statement conflicts with other evidence of record; or, there is a... relationship in question. (Authority: 38 U.S.C. 5124) (b) Marriage or birth. The classes of evidence to...

  17. Effective Evidence and Presentation for Influencing a Factfinder or Arbitrator.

    Science.gov (United States)

    Zack, Arnold M.

    The purpose of both factfinding to settle a negotiations impasse and arbitration to settle a grievance is to present the evidence necessary to resolve the conflict between union and management. The author of this paper, himself a factfinder and arbitrator, lists tactics and practices that impede the efficient collection of evidence in factfinding.…

  18. The use of neuroscientific evidence in Canadian criminal proceedings.

    Science.gov (United States)

    Chandler, Jennifer A

    2015-11-01

    This article addresses the question of how neuroscientific evidence is currently used in the Canadian criminal justice system, with a view to identifying the main contexts in which this evidence is raised, as well as to discern the impact of this evidence on judgements of responsibility, dangerousness, and treatability. The most general Canadian legal database was searched for cases in the five-year period between 2008 and 2012 in which neuroscientific evidence related to the responsibility and recidivism risk of criminal offenders was considered. Canadian courts consider neuroscientific evidence of many types, particularly evidence of prenatal alcohol exposure, traumatic brain injury, and neuropsychological testing. The majority of the cases are sentencing decisions, which is useful given that it offers an opportunity to observe how judges wrestle with the tension that evidence of diminished capacity due to brain damage tends to reduce moral blameworthiness, while it also tends to increase perceptions of risk and dangerousness. This so-called double-edged sword of the biological explanation of criminal behavior was reflected in this study, and raises questions about whether and when the pursuit of such evidence is advisable from the defense perspective.

  19. 20 CFR 617.12 - Evidence of qualification.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Evidence of qualification. 617.12 Section 617... ASSISTANCE FOR WORKERS UNDER THE TRADE ACT OF 1974 Trade Readjustment Allowances (TRA) § 617.12 Evidence of qualification. (a) State agency action. When an individual applies for TRA, the State agency having...

  20. Interverntion, evidence-based research and everyday life

    DEFF Research Database (Denmark)

    Dreier, Ole

    2011-01-01

    Intervention is a key concept in the technology of psychology and it plays a decisive role in evidence-based research. But analyses of this concept are remarkably sparse. Based on a critical analysis of the conception of intervention in the American Psychological Association’s guidelines for evid...

  1. Probability Estimation in the Framework of Intuitionistic Fuzzy Evidence Theory

    Directory of Open Access Journals (Sweden)

    Yafei Song

    2015-01-01

    Full Text Available Intuitionistic fuzzy (IF evidence theory, as an extension of Dempster-Shafer theory of evidence to the intuitionistic fuzzy environment, is exploited to process imprecise and vague information. Since its inception, much interest has been concentrated on IF evidence theory. Many works on the belief functions in IF information systems have appeared. Although belief functions on the IF sets can deal with uncertainty and vagueness well, it is not convenient for decision making. This paper addresses the issue of probability estimation in the framework of IF evidence theory with the hope of making rational decision. Background knowledge about evidence theory, fuzzy set, and IF set is firstly reviewed, followed by introduction of IF evidence theory. Axiomatic properties of probability distribution are then proposed to assist our interpretation. Finally, probability estimations based on fuzzy and IF belief functions together with their proofs are presented. It is verified that the probability estimation method based on IF belief functions is also potentially applicable to classical evidence theory and fuzzy evidence theory. Moreover, IF belief functions can be combined in a convenient way once they are transformed to interval-valued possibilities.

  2. 27 CFR 28.265 - Evidence of fraud.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Evidence of fraud. 28.265 Section 28.265 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... fraud. If the customs inspection discloses evidence of fraud, the customs officer shall detain...

  3. 24 CFR 1720.425 - Presentation and admission of evidence.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Presentation and admission of evidence. 1720.425 Section 1720.425 Housing and Urban Development Regulations Relating to Housing and Urban... PRACTICE Adjudicatory Proceedings Discovery and Evidence § 1720.425 Presentation and admission of...

  4. 40 CFR 66.94 - Presentation of evidence.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Presentation of evidence. 66.94 Section 66.94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Adjudicatory Hearings § 66.94 Presentation of evidence. (a) In hearings pursuant to § 66.42 EPA shall...

  5. 46 CFR 201.131 - Presentation of evidence.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Presentation of evidence. 201.131 Section 201.131... PRACTICE AND PROCEDURE Hearing Procedures (Rule 13) § 201.131 Presentation of evidence. (a) Testimony... specifically encouraged to cooperate with each other in joint presentations particularly in such items as...

  6. 19 CFR 10.198 - Evidence of country of origin.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Evidence of country of origin. 10.198 Section 10... § 10.198 Evidence of country of origin. (a) Shipments covered by a formal entry—(1) Articles not wholly the growth, product, or manufacture of a beneficiary country—(i) Declaration. In a case involving...

  7. 19 CFR 10.173 - Evidence of country of origin.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Evidence of country of origin. 10.173 Section 10... Generalized System of Preferences § 10.173 Evidence of country of origin. (a) Shipments covered by a formal entry—(1) Merchandise not wholly the growth, product, or manufacture of a beneficiary developing...

  8. 20 CFR 404.974 - Obtaining evidence from Appeals Council.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Obtaining evidence from Appeals Council. 404.974 Section 404.974 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND... and Decisions Appeals Council Review § 404.974 Obtaining evidence from Appeals Council. You...

  9. Teaching Evidence-Based Physical Diagnosis: Six Bedside Lessons.

    Science.gov (United States)

    McGee, Steven

    2016-12-01

    Evidence-based physical diagnosis is an essential part of the bedside curriculum. By using the likelihood ratio, a simple measure of diagnostic accuracy, teachers can quickly adapt this approach to their bedside teaching. Six recurring themes in evidence-based physical diagnosis are fully reviewed, with examples, in this article.

  10. The origins of medical evidence : communication and experimentation

    NARCIS (Netherlands)

    Widder, Joachim

    2004-01-01

    BACKGROUND: The experimental method to acquire knowledge about efficacy and efficiency of medical procedures is well established in evidence-based medicine. A method to attain evidence about the significance of diseases and interventions from the patients' perspectives taking into account their righ

  11. Striving for excellence with evidence-based dentistry.

    Science.gov (United States)

    Gillette, Jane

    2009-09-01

    With an explosion of published dental research, experienced dental practitioners may desire to update their clinical knowledge. Evidence-based dentistry provides a unique opportunity for dental practitioners to strive for excellence of scientific knowledge through evidence-finding processes that are not only simple, but have a significant potential to improve patient health care outcomes.

  12. 7 CFR 1493.280 - Evidence of export report.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export report. 1493.280 Section 1493.280... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.280 Evidence of export report. (a) Report of export....

  13. 20 CFR 410.473 - Evidence of continuation of disability.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Evidence of continuation of disability. 410... SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.473 Evidence of continuation of disability. An individual who has been determined to be...

  14. New Labour and Education: An Evidence-Based Analysis

    Science.gov (United States)

    Galton, Maurice

    2007-01-01

    This article looks at the evidence concerning performance and progress in the primary school over the lifetime of New Labour's tenure in government since 1997. It examines the claims made by New Labour that the Literacy and Numeracy Strategies have been an outstanding success and have changed the ways that teachers teach. On the evidence of the…

  15. Toward Evidence-Informed Policy and Practice in Child Welfare

    Science.gov (United States)

    Littell, Julia H.; Shlonsky, Aron

    2010-01-01

    Drawing on the authors' experience in the international Campbell Collaboration, this essay presents a principled and pragmatic approach to evidence-informed decisions about child welfare. This approach takes into account the growing body of empirical evidence on the reliability and validity of various methods of research synthesis. It also…

  16. 20 CFR 416.803 - Evaluation of evidence.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Evaluation of evidence. 416.803 Section 416..., BLIND, AND DISABLED Determination of Age § 416.803 Evaluation of evidence. Generally, the highest... other family record, church record of baptism or confirmation in youth or early adult life,...

  17. Temporal displacement of environmental crime : Evidence from marine oil pollution

    NARCIS (Netherlands)

    Vollaard, Ben

    2017-01-01

    We provide evidence for temporal displacement of illegal discharges of oil from shipping, a major source of ocean pollution, in response to a monitoring technology that features variation in the probability of conviction by time of day. During the nighttime, evidence collected by Coast Guard aircraf

  18. Need to Address Evidence-Based Practice in Educational Administration

    Science.gov (United States)

    Kowalski, Theodore

    2009-01-01

    Purpose: This article presents a case for addressing evidence-based practice (EBP) in educational administration. Content is arranged around four objectives: (a) summarizing the status of educational administration as a profession, (b) defining evidence and the model, (c) explaining EBP's social and professional merit, and (d) identifying barriers…

  19. 7 CFR 1488.9 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1488.9 Section 1488.9 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Documents Required for Financing § 1488.9 Evidence of export. (a) If the commodity is exported by rail...

  20. 7 CFR 1493.470 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.470 Section 1493.470... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee Program Operations § 1493.470 Evidence of export. (a) Report of export....

  1. 7 CFR 46.23 - Evidence of dumping.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Evidence of dumping. 46.23 Section 46.23 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Receivers § 46.23 Evidence of dumping. Reasonable cause for destroying any produce exists when the...

  2. 7 CFR 48.7 - Evidence to justify dumping.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Evidence to justify dumping. 48.7 Section 48.7... Dumping § 48.7 Evidence to justify dumping. Any person, receiving produce in interstate commerce or in the..., prior to such destroying, abandoning, discarding or dumping, obtain a dumping certificate or...

  3. 42 CFR 93.519 - Admissibility of evidence.

    Science.gov (United States)

    2010-10-01

    ... Rules of Evidence (FRE). However, the ALJ may apply the FRE where appropriate (e.g., to exclude... undue delay or needless presentation of cumulative evidence under FRE 401-403. (d) The ALJ must exclude... permitted under FRE 201 (Judicial Notice of Adjudicative Facts). (1) The ALJ may take judicial notice of...

  4. 10 CFR 1015.504 - Preservation of evidence.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preservation of evidence. 1015.504 Section 1015.504 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) COLLECTION OF CLAIMS OWED THE UNITED STATES Referrals to the Department of Justice § 1015.504 Preservation of evidence. DOE will take care to preserve all files...

  5. Adult Reformulations of Child Errors as Negative Evidence.

    Science.gov (United States)

    Chouinard, Michelle M.; Clark, Eve V.

    2003-01-01

    Examined whether there was negative evidence in adult reformulations of erroneous child utterances, and if so, whether children made use of that evidence. Findings show that adults reformulate erroneous utterances often enough for learning to occur. Children can detect differences between their own utterance and the adult reformulation and make…

  6. The evidence base for professional and self-care prevention

    DEFF Research Database (Denmark)

    Twetman, Svante

    2015-01-01

    and fissure sealants. The quality of evidence for fluoride gel, fluoride mouth rinse, xylitol gums and silver diamine fluoride (SDF) was rated as low. For secondary caries prevention and caries arrest, only fluoride interventions and SDF proved consistent benefits, although the quality of evidence was low...

  7. Evidence of hawking (falconry) from bird and mammal bones

    NARCIS (Netherlands)

    Prummel, W.

    1997-01-01

    This paper deals with the archaeozoological and archaeological evidence for hawking, or falconry. The methods and history of hawking in Europe are described, after which five types of evidence for hawking are discussed. These are illustrated with material from the Slavonic stronghold of Oldenburg in

  8. Weighing the evidence of common beliefs in obesity research

    DEFF Research Database (Denmark)

    Casazza, Krista; Brown, Andrew; Astrup, Arne

    2015-01-01

    Abstract Obesity is a topic on which many views are strongly held in the absence of scientific evidence to support those views, and some views are strongly held despite evidence to contradict those views. We refer to the former as "presumptions" and the latter as "myths". Here we present nine myths...

  9. Dissecting Practical Intelligence Theory: Its Claims and Evidence.

    Science.gov (United States)

    Gottfredson, Linda S.

    2003-01-01

    The two key theoretical propositions of "Practical Intelligence in Everyday Life" are made plausible only if one ignores considerable evidence contradicting them. The six key empirical claims rest primarily on the illusion of evidence enhanced by selective reporting of results. (SLD)

  10. Mood-Congruent Memory and Natural Mood: New Evidence.

    Science.gov (United States)

    Mayer, John D.; And Others

    1995-01-01

    Presents new evidence that everyday mood does bring about a hypothesized effect on memory, termed mood-congruent memory (MCM). Results of three studies provided evidence for MCM among normal individuals (n=614). Findings support prior studies and bolster notions that mood and memory constantly covary in everyday experience. (RJM)

  11. Evidence-Based Treatment and Stuttering--Historical Perspective

    Science.gov (United States)

    Prins, David; Ingham, Roger J.

    2009-01-01

    Purpose: To illustrate the way in which both fluency shaping (FS) and stuttering management (SM) treatments for developmental stuttering in adults are evidence based. Method: A brief review of the history and development of FS and SM is provided. It illustrates that both can be justified as evidence-based treatments, each treatment seeking…

  12. Behavioral Activation Is an Evidence-Based Treatment for Depression

    Science.gov (United States)

    Sturmey, Peter

    2009-01-01

    Recent reviews of evidence-based treatment for depression did not identify behavioral activation as an evidence-based practice. Therefore, this article conducted a systematic review of behavioral activation treatment of depression, which identified three meta-analyses, one recent randomized controlled trial and one recent follow-up of an earlier…

  13. Evidence-based decision-making: when it is worthwhile

    Directory of Open Access Journals (Sweden)

    Ignacio Neuman

    2014-06-01

    Full Text Available Every day health professionals have to make dozens of decisions regarding patient care and management. It is not easy to integrate scientific evidence in this process. The primary ability we need in order to achieve successful results is learning how to recognize the circumstances in which evidence arising from results of scientific trials may help.

  14. An innovative clinical practicum to teach evidence-based practice.

    Science.gov (United States)

    Brancato, Vera C

    2006-01-01

    A clinical practicum was successfully implemented for RN to BSN students to apply evidence-based practice to actual clinical problems affecting nursing practice. The author describes how this practicum was implemented and the requisite resources and support systems. This senior-level capstone course enabled students to understand and value a lifelong learning approach to evidence-based practice.

  15. 42 CFR 426.517 - CMS' statement regarding new evidence.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false CMS' statement regarding new evidence. 426.517... DETERMINATIONS Review of an NCD § 426.517 CMS' statement regarding new evidence. (a) CMS may review any new... experts; and (5) Presented during any hearing. (b) CMS may submit a statement regarding whether the...

  16. Top 10 Lines of Evidence for Human Evolution.

    Science.gov (United States)

    Nickels, Martin

    2001-01-01

    Provides 10 lines of evidence that support the theory of human evolution. The evidence relates to hierarchical taxonomic classification, comparative anatomy, comparative embryology and development, comparative biochemistry, adaptive compromises, vestigial structures, biogeography, the fossil sequence, ecological coherence of fossil assemblages,…

  17. How is evidence to be understood in modern coaching psychology?

    DEFF Research Database (Denmark)

    Spaten, Ole Michael; Løkken, Lillith Olesen

    2015-01-01

    The hunt for evidence in modern coaching psychology could be counter-productive, and possibly lead to a simplified approach to research, practice, searching for “definitive truths”. The article discuss a critical approach to evidence hierarchies, and the prevalent (medical) understanding...

  18. Quality assurance and evidence in career guidance in Europe

    DEFF Research Database (Denmark)

    Plant, Peter

    2011-01-01

    Quality assurance and evidence in career guidance in Europe is based on a particular, positivtic model. Other approaches are largely neglected.......Quality assurance and evidence in career guidance in Europe is based on a particular, positivtic model. Other approaches are largely neglected....

  19. Nanotechnology and human health: Scientific evidence and risk governance

    DEFF Research Database (Denmark)

    . As complexity and uncertainty are large, risk assessment is challenging, and formulation of evidence-based policies and regulations elusive. Innovative models and frameworks for risk assessment and risk governance are being developed and applied to organize the available evidence on biological and health...

  20. Determinants of Evidence Use in Academic Librarian Decision Making

    Science.gov (United States)

    Koufogiannakis, Denise

    2015-01-01

    The objective of this qualitative study was to identify and explain challenges encountered by academic librarians when trying to incorporate evidence into their practice. The findings resulted in the identification of five main determinants that act as either obstacles or enablers of evidence use. The identification of these determinants provide…