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Sample records for antiproton radiotherapy peripheral

  1. Antiproton radiotherapy: peripheral dose from secondary neutrons

    DEFF Research Database (Denmark)

    Fahimian, Benjamin P.; DeMarco, John J.; Keyes, Roy;

    2009-01-01

    -based human phantom. The MCNPX Monte Carlo code was employed to quantify the peripheral dose for a cylindrical spread out Bragg peak representing a treatment volume of 1 cm diameter and 1 cm length in the frontal lobe of a segmented whole-body phantom of a 38 year old male. The secondary neutron organ dose...

  2. Antiproton Radiotherapy Peripheral Dose from Secondary Neutrons produced in the Annihilation of Antiprotons in the Target

    CERN Document Server

    Fahimian, Benjamin P; Keyes, Roy; Bassler, Niels; Iwamoto, Keisuke S; Zankl, Maria; Holzscheiter, Michael H

    2009-01-01

    The AD-4/ACE collaboration studies the biological effects of antiprotons with respect to a possible use of antiprotons in cancer therapy. In vitro experiments performed by the collaboration have shown an enhanced biological effectiveness for antiprotons relative to protons. One concern is the normal tissue dose resulting from secondary neutrons produced in the annihilation of antiprotons on the nucleons of the target atoms. Here we present the first organ specific Monte Carlo calculations of normal tissue equivalent neutron dose in antiproton therapy through the use of a segmented CT-based human phantom. The MCNPX Monte Carlo code was employed to quantify the peripheral dose for a cylindrical spread out Bragg peak representing a treatment volume of 1 cm diameter and 1 cm length in the frontal lobe of a segmented whole-body phantom of a 38 year old male. The secondary neutron organ dose was tallied as a function of energy and organ.

  3. Antiproton radiotherapy

    CERN Document Server

    Bassler, Niels; Beyer, Gerd; DeMarco, John J.; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Iwamoto, Keisuke S.; Jakel, Oliver; Knudsen, Helge V.; Kovacevic, Sandra; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen B.à; Solberg, Timothy D.; Sørensen, Brita S.; Vranjes, Sanja; Wouters, Bradly G.; Holzscheiter, Michael H.

    2008-01-01

    Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton–proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20–30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the rad...

  4. Relative Biological Effectiveness and Peripheral Damage of Antiproton Annihilation

    CERN Multimedia

    Kavanagh, J N; Kaiser, F; Tegami, S; Schettino, G; Kovacevic, S; Hajdukovic, D; Welsch, C P; Currell, F J; Toelli, H T; Doser, M; Holzscheiter, M; Herrmann, R; Timson, D J; Alsner, J; Landua, R; Knudsen, H; Comor, J; Moller, S P; Beyer, G

    2002-01-01

    The use of ions to deliver radiation to a body for therapeutic purposes has the potential to be significant improvement over the use of low linear energy transfer (LET) radiation because of the improved energy deposition profile and the enhanced biological effects of ions relative to photons. Proton therapy centers exist and are being used to treat patients. In addition, the initial use of heavy ions such as carbon is promising to the point that new treatment facilities are planned. Just as with protons or heavy ions, antiprotons can be used to deliver radiation to the body in a controlled way; however antiprotons will exhibit additional energy deposition due to annihilation of the antiprotons within the body. The slowing down of antiprotons in matter is similar to that of protons except at the very end of the range beyond the Bragg peak. Gray and Kalogeropoulos estimated the additional energy deposited by heavy nuclear fragments within a few millimeters of the annihilation vertex to be approximately 30 MeV (...

  5. Antiprotons

    Science.gov (United States)

    Chamberlain, Owen; Segre, Emilio; Wiegand, Clyde

    1955-11-29

    Since the development of Dirac's theory of the electron and the brilliant confirmation of one of its most startling predictions by the discovery of the positron by Anderson, it has been assumed most likely that the proton would also have its charge conjugate, the antiproton. The properties that define the antiproton are: (a) charge equal to the electron charge (also in sign); (b) mass equal to the proton mass; (c) stability against spontaneous decay; (d) ability to annihilate by interaction with a proton or neutron, probably generating pions and releasing in some manner the energy 2 mc{sup 2}; (e) generation in pairs with ordinary nucleons; (f) magnetic moment equal but opposite to that of the proton; (g) fermion of spin 1/2. Not all these properties are independent, but all might ultimately be subjected to experiment.

  6. Neutron Fluence in Antiproton Radiotherapy, Measurements and Simulations

    International Nuclear Information System (INIS)

    Introduction: A significant part of the secondary particle spectrum from antiproton annihilation consists of fast neutrons, which may contribute to a significant dose background found outside the primary beam. Materials and Methods: Using a polystyrene phantom as a moderator, we have performed absolute fluence measurements of the thermalized part of the fast neutron spectrum using Lithium-6 and -7 Fluoride TLD pairs. The results were compared with the Monte Carlo particle transport code FLUKA. Results: The experimental results are found to be in good agreement with simulations. The thermal neutron kerma resulting from the measured thermal neutron fluence is insignificant compared to the contribution from fast neutrons. Discussion: The secondary neutron fluences encountered in antiproton therapy are found to be similar to values calculated for pion treatment, however exact modeling under more realistic treatment scenarios is still required to quantitatively compare these treatment modalities.

  7. Simulation of an antiprotons beam applied to the radiotherapy; Simulacao de um feixe de antiprotons aplicado a radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Prata, Leonardo de Almeida

    2006-07-15

    Results for the interaction of a antiproton beam with constituent nuclei of the organic matter are presented. This method regards of the application of an computational algorithm to determine quantitatively the differential cross sections for the scattered particles, starting from the interaction of these antiprotons with the nuclei, what will allow in the future to draw the isodose curve for antiproton therapy, once these beams are expected to be used in cancer treatment soon. The calculation will be done through the application of the concepts of the method of intranuclear cascade, providing yield and differential cross sections of the scattered particles, present in the software MCMC. Th algorithm was developed based on Monte Carlo's method, already taking into account a validate code. The following physical quantities are presented: the yield of secondary particles, their spectral and angular distributions for these interactions. For the energy range taken into account the more important emitted particles are protons, neutrons and pions. Results shown that emitted secondary particles can modify the isodose curves, because they present high yield and energy for transverse directions. (author)

  8. Peripheral blood count in preoperative radiotherapy (with radiomodificators) of lung cancer

    International Nuclear Information System (INIS)

    Indices of peripheral blood in 215 patients with lung cancer during preoperative radiation using hyperglycemia or metronidazole are studied. It is shown that after preoperative radiotherapy, when radiomodifying effects are not used, the content of erythrocytes, thrombocytes, leukocytes, the concentration of hemoglobin in peripheral blood, as well as erythrocyte sedimentation rare didn't change. Functional disorders of the leukopoietic function and the thrombopoietic function of bone marrow when using metronidazole are registered when applying various types of preoperative radiotherapy. Lymphopenia is established when using various types of radiotherapy with radiomodificators

  9. Influence of peripheral blood hemoglobin concentration on the result of radiotherapy for nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Objective: To determine the influence of peripheral blood hemoglobin concentration on the radiotherapy result of nasopharyngeal carcinoma (NPC). Methods: From January 1989 to December 1998, 304 patients with pathologically confirmed NPC received radical radiation. There were 209 males and 95 females. The ages ranged from 16 to 77 years with a median of 42. All patients were irradiated by 60Co or 6 MV external beam with a total dose of 64 - 76 Gy for the primary tumor and 46 - 77 Gy for the cervical lymph nodes. The peripheral blood hemoglobin concentration for all patients was measured before, during and after radiotherapy. These patients were divided into three groups according to the peripheral blood hemoglobin concentration before radiotherapy: anemia ( 160 g/L), and into two groups according to the change in the peripheral blood hemoglobin concentration during radiotherapy as increased and decreased groups. Results: All patients were followed with a follow-up rate of 90.5%. The peripheral blood hemoglobin concentration had a significant effect on the survival of NPC patients. Its decrease or increase during radiotherapy affected the survival and local control rates of NPC patients. Conclusions: The change of peripheral hemoglobin concentration affecting the oxygen content in the blood, can influence the local control and survival rates of NPC patients. Increase results in higher survival

  10. Threshold dose for peripheral neuropathy following intraoperative radiotherapy (IORT) in a large animal model

    International Nuclear Information System (INIS)

    Radiation injury to peripheral nerve is a dose-limiting toxicity in the clinical application of intraoperative radiotherapy, particularly for pelvic and retroperitoneal tumors. Intraoperative radiotherapy-related peripheral neuropathy in humans receiving doses of 20-25 Gy is manifested as a mixed motor-sensory deficit beginning 6-9 months following treatment. In a previous experimental study of intraoperative radiotherapy-related neuropathy of the lumbro-sacral plexus, an approximate inverse linear relationship was reported between the intraoperative dose (20-75 Gy range) and the time to onset of hind limb paresis (1-12 mos following intraoperative radiotherapy). The principal histological lesion in irradiated nerve was loss of large nerve fibers and perineural fibrosis without significant vascular injury. Similar histological changes in irradiated nerves were found in humans. To assess peripheral nerve injury to lower doses of intraoperative radiotherapy in this same large animal model, groups of four adult American Foxhounds received doses of 10, 15, or 20 Gy to the right lumbro-sacral plexus and sciatic nerve using 9 MeV electrons. The left lumbro-sacral plexus and sciatic nerve were excluded from the intraoperative field to allow each animal to serve as its own control. Following treatment, a complete neurological exam, electromyogram, and nerve conduction studies were performed monthly for 1 year. Monthly neurological exams were performed in years 2 and 3 whereas electromyogram and nerve conduction studies were performed every 3 months during this follow-up period. With follow-up of greater than or equal to 42 months, no dog receiving 10 or 15 Gy IORT shows any clinical or laboratory evidence of peripheral nerve injury. However, all four dogs receiving 20 Gy developed right hind limb paresis at 8, 9, 9, and 12 mos following intraoperative radiotherapy

  11. Paralysis of the peripheral nerve following radiotherapy for mammary carcinoma

    International Nuclear Information System (INIS)

    After radiation therapy of 135 cases with postoperative or recurrent breast carcinoma, complete mortor paralysis of the fingers, the hand or the arm was noticed in five cases. The patient with paralysis of the peripheral nerve originated in brachial plexus, was accompained with edema of the arm and subcutaneous induration of the clavico-axillar region. The latent period of this complication was 6.3 years on the average. The tolerance dose of the brachial plexus was estimated to be 6,600 rad/40 days in minimum and NSD was about 1950 ret. (author)

  12. Clinical toxicity of peripheral nerve to intraoperative radiotherapy in a canine model

    International Nuclear Information System (INIS)

    Purpose: The clinical late effects of intraoperative radiotherapy (IORT) on peripheral nerve were investigated in a foxhound model. Methods and Materials: Between 1982 and 1987, 40 animals underwent laparotomy with intraoperative radiotherapy of doses from 0-75 Gy administered to the right lumbosacral plexus. Subsequently, all animals were monitored closely and sacrificed to assess clinical effects to peripheral nerve. This analysis reports final clinical results of all animals, with follow-up to 5 years. Results: All animals treated with ≥ 25 Gy developed ipsilateral neuropathy. An inverse relationship was noted between intraoperative radiotherapy dose and time to neuropathy, with an effective dose for 50% paralysis (ED50) of 17.2 Gy. One of the animals treated with 15 Gy IORT developed paralysis, after a much longer latency than the other animals. Conclusions: Doses of 15 Gy delivered intraoperatively may be accompanied by peripheral neuropathy with long-term follow-up. This threshold is less than that reported with shorter follow-up. The value of ED50 determined here is in keeping with data from other animal trials, and from clinical trials in humans

  13. Antiproton production

    International Nuclear Information System (INIS)

    The results for the antiproton momentum spectrum produced in proton reactions on lead at the CERN Antiproton Accumulator is scaled to AGS operating conditions using the Sanford-Wang formula with no correction for target material. Yield predictions as a function of momentum are shown for 28.3 GeV protons on beryllium and results are converted to antiproton beam flux. The AGS Medium Energy Separated Beam has a flux which is a factor of 2 lower than Sanford-Wang predictions. This may be due to factors affecting beam acceptance

  14. Peripheral doses in modulated intensive radiotherapy (MIRT) and its implications in radiological protection

    International Nuclear Information System (INIS)

    A calculation model based on the theory of photon transport, to estimate the peripheral energy fluence (fluence occurring outside the radiation beam) produced by the dispersions of photon compensating filters used was developed in IMRT mode, in a treatment room radiotherapy service of FUESMEN. In order to validate the model were experimentally determined fluences and peripheral dose for three different sizes of compensating filters. It was found that there is a slight systematic overestimation model with respect to experimental results. The experimental values also allowed the comparison of the peripheral doses with other modalities. Furthermore, a model was developed to estimate the annual dose that occurs at any point to be protected with a shield, from the theoretical values obtained from peripheral energy flow. Using the theoretical values automatically allowed to take a conservative approach because of the slight overestimation already mentioned, the couple have a calculation model for widespread use. It was found that the contribution of the peripheral dose to the annual dose is more than significant, thus suggesting that the same should be considered in the design calculations of secondary barriers

  15. Antiprotonic helium

    CERN Multimedia

    Eades, John

    2005-01-01

    An exotic atom in w hich an electron and an antiproton orbit a helium nucleus could reveal if there are any differences between matter and antimatter. The author describes this unusual mirror on the antiworld (5 pages)

  16. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy

    International Nuclear Information System (INIS)

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of 69 Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  17. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  18. The Antiproton Accumulator becomes Antiproton Decelerator

    CERN Multimedia

    1980-01-01

    The photos show the Antiproton Accumulator (AA) transformed into Antiproton Decelerator. The AA was used at CERN between 1981 and 1999 before being replaced by the Antiproton Decelerator (AD). The AA was used to collect and stochastically cool antiprotons used in proton-antiproton collisions in the SPS collider. This lead to the discovery of the W and Z bosons in 1983 and the Nobel Prize for Carlo Rubbia and Simon van der Meer in 1984.

  19. Frequency of unstable chromosome aberrations in peripheral lymphocytes of women with breast cancer treated with radiotherapy

    International Nuclear Information System (INIS)

    This study proposes to obtain information about the behavior of the frequency and distribution of radiation induced lymphocyte dicentric chromosome aberrations with therapeutic doses in women with breast cancer treated only with radiotherapy, about which there are no existing works in Chile. Blood samples were taken from 6 women volunteers included in the study, with their informed consent, treated in the Fundacion Arturo Lopez Perez, aged 24 to 65 years old, without prior or parallel chemotherapy, nor prior radiotherapy. Three peripheral blood samples were taken from each patient in 0, 16.2 and 43.2 Gy doses. The lymphocytes obtained from each sample were cultivated using the micro-culture technique following the protocol in IAEA Technical Report No. 405, 2001. The samples were evaluated under a microscope and the unstable chromosome aberrations for lymphocytes were counted. A total of 500 cells per sample was evaluated in most cases, which were distributed depending on the number of aberrations that they had. The results were analyzed by treatment dose for each of the study patients, using the Papworth u test, Dolphin's 'Contaminated Poisson' method and Sasaki's 'QDR'. Great variations were observed in the frequency distribution of aberrations among the patients studied, which could be due to the influence of factors related to the patients' partial irradiations (C.Wood)

  20. Calculated LET Spectrum from Antiproton Beams Stopping in Water

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael

    2009-01-01

    Antiprotons have been proposed as a potential modality for radiotherapy because the annihilation at the end of range leads to roughly a doubling of physical dose in the Bragg peak region. So far it has been anticipated that the radiobiology of antiproton beams is similar to that of protons in the...

  1. Effect of BCG cell-wall skeleton immunotherapy on the peripheral blood lymphocytes in patients with lung cancer after radiotherapy

    International Nuclear Information System (INIS)

    The effect of radiotherapy on peripheral blood lymphocytes (PBL) of lung cancer and the effect of BCG cell-wall skeleton (BCG-CWS) on recovery of impaired PBL were examined. A remarkable depression of the absolute number of E- or EAC-rosette cells and of the response of PBL to mitogens were observed immediately after radiotherapy, and these continued for several months. With BCG-CWS immunotherapy, the response of PBL to phytohemagglutinin recovered rapidly, compared with non-vaccinated patients. The response of PBL to pokeweed mitogen seemed to give similar results. These results suggested that BCG-CWS injection to the patient receiving radiotherapy was effective for recovery of T-cell response. (author)

  2. Peripheral dose measurements in cervical cancer radiotherapy: a comparison of volumetric modulated arc therapy and step-and-shoot IMRT techniques

    OpenAIRE

    Jia, Ming X; ZHANG, XU; Yin, Ce; Feng, Ge; Li, Na; Gao, Song; Liu, Da W

    2014-01-01

    Purpose The aim of this study was to investigate the peripheral doses resulting from volumetric modulated arc therapy (VMAT) and intensity modulated radiotherapy (IMRT) techniques in cervical cancer radiotherapy. Methods Nine patients with cervical cancer had treatment planned with both VMAT and IMRT. A specially designed phantom was used for this study, with ion chambers placed at interest points approximating the position of the breast, thyroid, and lens. The peripheral doses at the phantom...

  3. Antiproton Cancer Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels

    Antiprotons are interesting as a modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, they behave as protons. Well before the Bragg-peak, protons and antiprotons have near identical stopping powers exhibit equal radiobiology. But when the antiprotons co...

  4. Tolerance of peripheral nerve to intraoperative radiotherapy (IORT): clinical and experimental studies

    International Nuclear Information System (INIS)

    In clinical experience of combining wide excision and intraoperative radiotherapy (IORT), five patients have developed clinical signs of lumbosacral or sciatic neuropathy within 9 months of receiving IORT to a dose of 20-25 Gy. Three patients showed recovery of nerve function over several months while two patients have shown no recovery and have near complete loss of extremity function. In an attempt to investigate this clinical observation further, the lumbosacral plexus and sciatic nerve of American foxhounds were surgically exposed and received a single dose of IORT ranging from 20-75 Gy. An approximate linear relationship between radiation dose and time to onset of hind limb paresis is found with 19 of 21 irradiated dogs showing clinical signs of nerve injury within an interval of 1-19 months. No recovery of nerve function is seen in these dogs. Histological study of the irradiated nerves demonstrates a loss of nerve fibers, particularly those of the large myelinated type without evidence of vascular occlusion or thrombosis. These studies suggest that peripheral nerve may be a dose-limiting normal tissue in clinical studies of IORT

  5. Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest

    OpenAIRE

    Kavanagh, J. N.; Currell, F. J.; Timson, D.J.; Savage, K. I.; Richard, D J; S.J. McMahon(Particle Physics Department, Rutherford Appleton Laboratory, Didcot, United Kingdom); Hartley, Oliver; Cirrone, G. A. P.; Romano, F.; Prise, K M; Bassler, N.; Holzscheiter, M. H.; Schettino, G

    2013-01-01

    Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (,19 keV/mm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual c-H2AX foci compared to X-ra...

  6. The biological effectiveness of antiproton irradiation

    DEFF Research Database (Denmark)

    Holzscheiter, Michael H.; Bassler, Niels; Agazaryan, Nzhde;

    2006-01-01

    Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first...... ever measurements of the biological effectiveness of antiprotons. Materials and methods: V79 cells were suspended in a semi-solid matrix and irradiated with 46.7 MeV antiprotons, 48 MeV protons, or 60Co c-rays. Clonogenic survival was determined as a function of depth along the particle beams. Dose and...... particle fluence response relationships were constructed from data in the plateau and Bragg peak regions of the beams and used to assess the biological effectiveness. Results: Due to uncertainties in antiproton dosimetry we defined a new term, called the biologically effective dose ratio (BEDR), which...

  7. SU-E-T-43: Analytical Model for Photon Peripheral Dose in Radiotherapy Treatments

    Energy Technology Data Exchange (ETDEWEB)

    Nieto, B Sanchez; El far, R [Instituto de Fisica, Pontificia Universidad Catolica de Chile, Santiago, Santiago De Chile (Chile); Romero-Exposito, M [Universitat Autonoma de Barcelona, Barcelona (Spain); Lagares, J [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Madrid (Spain); Mateo, JC [Hospital Duques del Infantado, Sevilla (Spain); Terron, JA [Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla (Spain); Irazola, L; Sanchez-Doblado, F [Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla (Spain); Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Sevilla (Spain)

    2014-06-01

    Purpose: The higher survival rate of radiotherapy patients entails a growing concern on second cancers associated to peripheral doses. Currently, dosimetry of out-of field doses is still under development. Our group has developed a methodology to estimate neutron equivalent dose in organs (1,2). We aimed to propose a model to estimate out-of-field photon doses in isocentric treatments from basic clinical data. Methods: The proposed function models the dose as the sum of leakage and scatter terms. The latter is modeled as a virtual source at the collimator, which suffers from attenuation in air and tissue, corrected by the inverse-square-law. The model was parameterized using experimental measurements with TLD700 chips placed inside an anthropomorphic phantom (6–18MV) irradiated with conformal and modulated techniques in Elekta, Siemens and Varian linacs. This model provides photon dose at a point as a function of clinical parameters as prescription dose/UM, PTV volume, distance to the field edge, height of the MLC leaves and distance from the the MLC to the isocenter. Model was tested against independent measurements (TLD100) for a VMAT treatment on a Elekta. Dose to organs is modeled from dose to points along the head-to-feet axis of the organ of a “standard man” escalated by patient height. Results: Our semi-empirical model depends on 3 given parameters (leakage parameter can be individualized). A novelty of our model, over other models (e.g., PERIDOSE), arises from its applicability to any technique (independently of the number of MU needed to deliver a dose). Differences between predictions and measurements were < 0.005mSv/UM. Conclusion: We have proposed a unique model which successfully account for photon peripheral organ dose. This model can be applied in the day-to-day clinic as it only needs a few basic parameters which are readily accessible.1. Radiother. Oncol. 107:234–243, 2013. 2. Phys. Med. Biol. 57:6167–6191, 2012.

  8. Radiation-Induced Micro-RNA Expression Changes in Peripheral Blood Cells of Radiotherapy Patients

    International Nuclear Information System (INIS)

    Purpose: MicroRNAs (miRNAs), a class of noncoding small RNAs that regulate gene expression, are involved in numerous physiologic processes in normal and malignant cells. Our in vivo study measured miRNA and gene expression changes in human blood cells in response to ionizing radiation, to develop miRNA signatures that can be used as biomarkers for radiation exposure. Methods and Materials: Blood from 8 radiotherapy patients in complete remission 1 or 2 was collected immediately before and 4 hours after total body irradiation with 1.25 Gy x-rays. Both miRNA and gene expression changes were measured by means of quantitative polymerase chain reaction and microarray hybridization, respectively. Hierarchic clustering, multidimensional scaling, class prediction, and gene ontology analysis were performed to investigate the potential of miRNAs to serve as radiation biomarkers and to elucidate their likely physiologic roles in the radiation response. Results: The expression levels of 45 miRNAs were statistically significantly upregulated 4 hours after irradiation with 1.25 Gy x-rays, 27 of them in every patient. Nonirradiated and irradiated samples form separate clusters in hierarchic clustering and multidimensional scaling. Out of 223 differentially expressed genes, 37 were both downregulated and predicted targets of the upregulated miRNAs. Paired and unpaired miRNA-based classifiers that we developed can predict the class membership of a sample with unknown irradiation status, with accuracies of 100% when all 45 upregulated miRNAs are included. Both miRNA control of and gene involvement in biologic processes such as hemopoiesis and the immune response are increased after irradiation, whereas metabolic processes are underrepresented among all differentially expressed genes and the genes controlled by miRNAs. Conclusions: Exposure to ionizing radiation leads to the upregulation of the expression of a considerable proportion of the human miRNAome of peripheral blood cells

  9. Radiotherapy

    International Nuclear Information System (INIS)

    This review highlights developments over the past decade in radiotherapy and attempts to summarize the state of the art in the management of the major diseases in which radiotherapy has a meaningful role. The equipment, radiobiology of radiotherapy and carcinoma of the lung, breast and intestines are highlighted

  10. Antiproton-Decelerator (AD)

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    When the Low-Energy Antiproton Ring (LEAR) was stopped in 1996, because of its costly operation, a cheaper way of continuing low-energy antiproton physics was sought. The Antiproton-Collector (AC), added in 1987 to the Antiproton Accumulator (AA) to provide a tenfold intensity increase, was converted into the Antiproton-Decelerator (AD). Antiprotons from the target at 3.5 GeV/c are decelerated to 100 MeV/c, and fast-ejected to the experiments. Major changes were necessary. Above all, the conversion from a constant-field machine to one with a magnetic cycle, modulating the field by an impressive factor 35. New systems for stochastic and electron cooling had to be added. Beam diagnostics at an intensity of only 2E7 antiprotons was a challenge. In 2000, the AD began delivery of antiprotons to the experiments.

  11. Antiproton Accumulator (AA)

    CERN Multimedia

    Photographic Service

    1980-01-01

    The AA in its final stage of construction, before it disappeared from view under concrete shielding. Antiprotons were first injected, stochastically cooled and accumulated in July 1980. From 1981 on, the AA provided antiprotons for collisions with protons, first in the ISR, then in the SPS Collider. From 1983 on, it also sent antiprotons, via the PS, to the Low-Energy Antiproton Ring (LEAR). The AA was dismantled in 1997 and shipped to Japan.

  12. Antiprotons get biological

    CERN Multimedia

    2003-01-01

    After its final run in September, the first results of the Antiproton Cell Experiment (ACE) look very promising. It was the first experiment to take data on the biological effects of antiproton beams to evaluate the potential of antiprotons in radiation therapy.

  13. Polarization of antiprotons by antiproton decay

    International Nuclear Information System (INIS)

    The production of polarized antiproton beams at Fermilab is briefly reviewed. Two types of high-energy anti p polarimeters are described - the Coulomb-nuclear polarimeter and the Primakoff-effect polarimeter. The production of 8.9 GeV/c polarized antiprotons before entering the Fermilab accumulator ring is then discussed. 5 refs., 6 figs

  14. Effect of fractionated regional external beam radiotherapy on peripheral blood cell count

    International Nuclear Information System (INIS)

    Purpose: The purpose of this study was to assess the need for obtaining weekly complete blood count (CBC) values and to identify the pattern of changes in CBC during regional conventional fractionated radiotherapy. Methods and Materials: A retrospective analysis of CBC data on 299 adult cancer patients who received definitive conventional radiotherapy to head and neck (n=95), chest (n=96), and pelvis (n=108) was performed. Temporal patterns and magnitude of change in white blood cells, neutrophils, lymphocytes, and platelets during radiotherapy were examined. Results: There were statistically significant declines in all counts, albeit not clinically significant. Notable differences between disease sites were found. The greatest weekly interval change in counts occurred during the first week of radiotherapy for all groups of patients. The mean WBC nadir values during treatment were 5.8 for head and neck, 6.8 for chest, and 5.4 for pelvis. The nadirs for all counts occurred toward the middle-to-end of radiotherapy. Lymphocytes were found to be more sensitive to radiotherapy than other leukocyte subcomponents. Conclusion: Our study suggests that weekly CBC monitoring is not necessary for all patients undergoing standard fractionated radiotherapy. Baseline blood counts may be used to determine an optimal schedule for monitoring CBCs in patients receiving conventional radiation alone. Reduced monitoring of CBC may result in significant financial savings

  15. Nuclear Excitations by Antiprotons and Antiprotonic Atoms

    CERN Multimedia

    2002-01-01

    The proposal aims at the investigation of nuclear excitations following the absorption and annihilation of stopped antiprotons in heavier nuclei and at the same time at the study of the properties of antiprotonic atoms. The experimental arrangement will consist of a scintillation counter telescope for the low momentum antiproton beam from LEAR, a beam degrader, a pion multiplicity counter, a monoisotopic target and Ge detectors for radiation and charged particles. The data are stored by an on-line computer.\\\\ \\\\ The Ge detectors register antiprotonic x-rays and nuclear @g-rays which are used to identify the residual nucleus and its excitation and spin state. Coincidences between the two detectors will indicate from which quantum state the antiprotons are absorbed and to which nuclear states the various reactions are leading. The measured pion multiplicity characterizes the annihilation process. Ge&hyphn. and Si-telescopes identify charged particles and determine their energies.\\\\ \\\\ The experiment will gi...

  16. Calculated LET-Spectrum of Antiprotons

    DEFF Research Database (Denmark)

    Bassler, Niels

    Introduction Antiprotons as a new beam modality in radiotherapy are being investigated by the AD-4/ACE collaboration since 2002. A beam of antiprotons hitting a water phantom exhibit a similar depth-dose curve as that known from protons, except that the Bragg-peak is significantly pronounced due...... primary particles, the increased stopping power of the secondary causes an increase in the dose averaged LET. The maximum LET is recorded in the peak as 19 keV/µm. Discussion The dose-average LET in the plateau region may result in a RBE different from unity in the plateau region. RBE measurements of...

  17. Effect of image-guided hypofractionated stereotactic radiotherapy on peripheral non-small-cell lung cancer

    OpenAIRE

    Ren, Juan; Wang, Shuwen; Yan, Yanli; Xue, Chaofan; Tan, Li; Ma, Xiaowei

    2016-01-01

    Shu-wen Wang,1 Juan Ren,1 Yan-li Yan,2 Chao-fan Xue,2 Li Tan,2 Xiao-wei Ma2 1Department of Radiotherapy, First Affiliated Hospital of Xian Jiaotong University, 2Medical School of Xian Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Abstract: The objective of this study was to compare the effects of image-guided hypofractionated radiotherapy and conventional fractionated radiotherapy on non-small-cell lung cancer (NSCLC). Fifty stage- and age-matched cases...

  18. Antiproton Focus Horn

    CERN Multimedia

    1974-01-01

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet.For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  19. ASACUSA hits antiproton jackpot

    CERN Multimedia

    2001-01-01

    The Japanese-European ASACUSA collaboration, which takes its name from the oldest district of Tokyo, approaches the antimatter enigma in a different way from the other two AD experiments, by inserting antiprotons into ordinary atoms. Last month the collaboration succeeded in trapping about a million antiprotons. The ASACUSA antiproton trap (lower cylinder), surmounted by its liquid helium reservoir. Looking on are Ken Yoshiki-Franzen, Zhigang Wang, Takahito Tasaki, Suzanne Reed, John Eades, Masaki Hori, Yasunori Yamazaki, Naofumi Kuroda, Jun Sakaguchi, Berti Juhasz, Eberhard Widmann and Ryu Hayano. A key element of the ASACUSA apparatus is its decelerating Radiofrequency Quadrupole magnet, RFQD. After tests with protons in Aarhus, this was installed in ASACUSA's antiproton beam last October (Bulletin 41/2000, 9 October 2000). Constructed by Werner Pirkl's group in PS Division, the RFQD works by applying an electric field to the AD antiproton pulse the opposite direction to its motion. As the antiprotons slo...

  20. Antiprotonic Helium Atoms

    OpenAIRE

    Kartavtsev, O. I.

    1995-01-01

    Metastable antiprotonic helium atoms $^{3,4}\\! H\\! e\\bar pe$ have been discovered recently in experiments of the delayed annihilation of antiprotons in helium media. These exotic atoms survive for an enormous time (about tens of microseconds) and carry the extremely large total angular momentum $L\\sim 30-40$. The theoretical treatment of the intrinsic properties of antiprotonic helium atoms, their formation and collisions with atoms and molecules is discussed.

  1. Peripheral dose in ocular treatments with CyberKnife and Gamma Knife radiosurgery compared to proton radiotherapy

    International Nuclear Information System (INIS)

    Peripheral radiation can have deleterious effects on normal tissues throughout the body, including secondary cancer induction and cataractogenesis. The aim of this study is to evaluate the peripheral dose received by various regions of the body after ocular treatment delivered with the Model C Gamma Knife, proton radiotherapy with a dedicated ocular beam employing no passive-scattering system, or a CyberKnife unit before and after supplemental shielding was introduced. TLDs were used for stray gamma and x-ray dosimetry, whereas CR-39 dosimeters were used to measure neutron contamination in the proton experiments. Doses to the contralateral eye, neck, thorax and abdomen were measured on our anthropomorphic phantom for a 56 Gy treatment to a 588 mm3 posterior ocular lesion. Gamma Knife (without collimator blocking) delivered the highest dose in the contralateral eye, with 402-2380 mSv, as compared with 118-234 mSv for CyberKnife pre-shielding, 46-255 mSv for CyberKnife post-shielding and 9-12 mSv for proton radiotherapy. Gamma Knife and post-shielding CyberKnife delivered comparable doses proximal to the treatment site, with 190 versus 196 mSv at the thyroid, whereas protons doses at these locations were less than 10 mSv. Gamma Knife doses decreased dramatically with distance from the treatment site, delivering only 13 mSv at the lower pelvis, comparable to the proton result of 4 to 7 mSv in this region. In contrast, CyberKnife delivered between 117 and 132 mSv to the lower pelvis. In conclusion, for ocular melanoma treatments, a proton beam employing no double scattering system delivers the lowest peripheral doses proximally to the contralateral eye and thyroid when compared to radiosurgery with the Model C Gamma Knife or CyberKnife. At distal locations in the pelvis, peripheral doses delivered with proton and Gamma Knife are of an order of magnitude smaller than those delivered with CyberKnife

  2. Peripheral dose in ocular treatments with CyberKnife and Gamma Knife radiosurgery compared to proton radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Zytkovicz, A; Daftari, I; Phillips, T L; Chuang, C F; Verhey, L; Petti, P L [Department of Radiation Oncology, University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 (United States)

    2007-09-21

    Peripheral radiation can have deleterious effects on normal tissues throughout the body, including secondary cancer induction and cataractogenesis. The aim of this study is to evaluate the peripheral dose received by various regions of the body after ocular treatment delivered with the Model C Gamma Knife, proton radiotherapy with a dedicated ocular beam employing no passive-scattering system, or a CyberKnife unit before and after supplemental shielding was introduced. TLDs were used for stray gamma and x-ray dosimetry, whereas CR-39 dosimeters were used to measure neutron contamination in the proton experiments. Doses to the contralateral eye, neck, thorax and abdomen were measured on our anthropomorphic phantom for a 56 Gy treatment to a 588 mm{sup 3} posterior ocular lesion. Gamma Knife (without collimator blocking) delivered the highest dose in the contralateral eye, with 402-2380 mSv, as compared with 118-234 mSv for CyberKnife pre-shielding, 46-255 mSv for CyberKnife post-shielding and 9-12 mSv for proton radiotherapy. Gamma Knife and post-shielding CyberKnife delivered comparable doses proximal to the treatment site, with 190 versus 196 mSv at the thyroid, whereas protons doses at these locations were less than 10 mSv. Gamma Knife doses decreased dramatically with distance from the treatment site, delivering only 13 mSv at the lower pelvis, comparable to the proton result of 4 to 7 mSv in this region. In contrast, CyberKnife delivered between 117 and 132 mSv to the lower pelvis. In conclusion, for ocular melanoma treatments, a proton beam employing no double scattering system delivers the lowest peripheral doses proximally to the contralateral eye and thyroid when compared to radiosurgery with the Model C Gamma Knife or CyberKnife. At distal locations in the pelvis, peripheral doses delivered with proton and Gamma Knife are of an order of magnitude smaller than those delivered with CyberKnife.

  3. Peripheral dose in ocular treatments with CyberKnife and Gamma Knife radiosurgery compared to proton radiotherapy

    Science.gov (United States)

    Zytkovicz, A.; Daftari, I.; Phillips, T. L.; Chuang, C. F.; Verhey, L.; Petti, P. L.

    2007-09-01

    Peripheral radiation can have deleterious effects on normal tissues throughout the body, including secondary cancer induction and cataractogenesis. The aim of this study is to evaluate the peripheral dose received by various regions of the body after ocular treatment delivered with the Model C Gamma Knife, proton radiotherapy with a dedicated ocular beam employing no passive-scattering system, or a CyberKnife unit before and after supplemental shielding was introduced. TLDs were used for stray gamma and x-ray dosimetry, whereas CR-39 dosimeters were used to measure neutron contamination in the proton experiments. Doses to the contralateral eye, neck, thorax and abdomen were measured on our anthropomorphic phantom for a 56 Gy treatment to a 588 mm3 posterior ocular lesion. Gamma Knife (without collimator blocking) delivered the highest dose in the contralateral eye, with 402-2380 mSv, as compared with 118-234 mSv for CyberKnife pre-shielding, 46-255 mSv for CyberKnife post-shielding and 9-12 mSv for proton radiotherapy. Gamma Knife and post-shielding CyberKnife delivered comparable doses proximal to the treatment site, with 190 versus 196 mSv at the thyroid, whereas protons doses at these locations were less than 10 mSv. Gamma Knife doses decreased dramatically with distance from the treatment site, delivering only 13 mSv at the lower pelvis, comparable to the proton result of 4 to 7 mSv in this region. In contrast, CyberKnife delivered between 117 and 132 mSv to the lower pelvis. In conclusion, for ocular melanoma treatments, a proton beam employing no double scattering system delivers the lowest peripheral doses proximally to the contralateral eye and thyroid when compared to radiosurgery with the Model C Gamma Knife or CyberKnife. At distal locations in the pelvis, peripheral doses delivered with proton and Gamma Knife are of an order of magnitude smaller than those delivered with CyberKnife.

  4. The CERN antiproton collector

    International Nuclear Information System (INIS)

    The Antiproton Collector is a new ring of much larger acceptance than the present accumulator. It is designed to receive 108 antiprotons per PS cycle. In order to be compatible with the Antiproton Accumulator, the momentum spread and the emittances are reduced from 6% to 0.2% and from 200 π mm mrad to 25 π mm mrad respectively. In addition to the ring itself, the new target area and the modifications to the stochastic systems of the Antiproton Accumulator are described. (orig.)

  5. Comparison of Optimized Single and Multifield Irradiation Plans of Antiproton, Proton and Carbon Ion Beams

    DEFF Research Database (Denmark)

    Bassler, Niels; Kantemiris, Ioannis; Karaiskos, Pantelis;

    2010-01-01

    Antiprotons have been suggested as a possibly superior modality for radiotherapy, due to the energy released when antiprotons annihilate, which enhances the Bragg peak and introduces a high-LET component to the dose. However, concerns are expressed about the inferior lateral dose distribution cau...

  6. Radiotherapy

    International Nuclear Information System (INIS)

    The book is focussed on the actual knowledge on the clinical radiotherapy and radio-oncology. Besides fundamental and general contributions specific organ systems are treated in detail. The book contains the following contributions: Basic principles, radiobiological fundamentals, physical background, radiation pathology, basics and technique of brachytherapy, methodology and technique of the stereotactic radiosurgery, whole-body irradiation, operative radiotherapy, hadron therapy, hpyerthermia, combined radio-chemo-therapy, biometric clinical studies, intensity modulated radiotherapy, side effects, oncological diagnostics; central nervous system and sense organs, head-neck carcinomas, breast cancer, thorax organs, esophagus carcinoma, stomach carcinoma, pancreas carcinoma, heptabiliary cancer and liver metastases, rectal carcinomas, kidney and urinary tract, prostate carcinoma, testicular carcinoma, female pelvis, lymphatic system carcinomas, soft tissue carcinoma, skin cancer, bone metastases, pediatric tumors, nonmalignant diseases, emergency in radio-oncology, supporting therapy, palliative therapy

  7. Neutrons from Antiproton Irradiation

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael; Petersen, Jørgen B.B.

    relative biological effect (RBE) has already been beam measured in spread out Bragg peaks of antiprotons, relative to that found in the plateau region. However, the antiproton annihilation process is associated with a substantial release of secondary particles which contribute to the dose outside the...

  8. LEAR: antiproton extraction lines

    CERN Multimedia

    Photographic Service

    1992-01-01

    Antiprotons, decelerated in LEAR to a momentum of 100 MeV/c (kinetic energy of 5.3 MeV), were delivered to the experiments in an "Ultra-Slow Extraction", dispensing some 1E9 antiprotons over times counted in hours. Beam-splitters and a multitude of beam-lines allowed several users to be supplied simultaneously.

  9. Antiproton Radiation Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael H.; Petersen, Jørgen B.B.

    2007-01-01

    investigated the radiobiological properties using antiprotons at 50 and 125 MeV from the Antiproton Decelerator (AD) at CERN. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with Chinese V79 WNRE hamster cells. Monte...

  10. Antiprotons at Solar Maximum

    CERN Document Server

    Bieber, J W; Engel, R; Gaisser, T K; Roesler, S; Stanev, T; Bieber, John W.; Engel, Ralph; Gaisser, Thomas K.; Roesler, Stefan; Stanev, Todor

    1999-01-01

    New measurements with good statistics will make it possible to observe the time variation of cosmic antiprotons at 1 AU through the approaching peak of solar activity. We report a new computation of the interstellar antiproton spectrum expected from collisions between cosmic protons and the interstellar gas. This spectrum is then used as input to a steady-state drift model of solar modulation, in order to provide predictions for the antiproton spectrum as well as the antiproton/proton ratio at 1 AU. Our model predicts a surprisingly large, rapid increase in the antiproton/proton ratio through the next solar maximum, followed by a large excursion in the ratio during the following decade.

  11. Peripheral doses in radiotherapy: A comparison between IMRT, VMAT and Tomotherapy

    International Nuclear Information System (INIS)

    The goal of this intercomparison is to determine the peripheral doses during treatment of prostate and head and neck (H and N) cancers. In the case of prostate cancer, two different treatment techniques are compared: intensity-modulated radiation therapy (IMRT – 10 MV and 18 MV), on a Varian Clinac 2100 C/D and Tomotherapy. VMAT (also on a Varian Clinac 2100 C/D) was compared to Tomotherapy, for H and N cancer. The treatment devices are located at the university hospitals of Leuven and Brussels, respectively. A common treatment protocol was agreed between the two clinical centers and this same protocol was used by each partner. For the higher energy modalities (10 MV and 18 MV) we also assessed the neutron contribution to the total dose, by using bubble detectors. In this way, the performance (in terms of peripheral doses) of the different treatment techniques, when faced with the same dose distribution constraints, was evaluated. The doses were evaluated with an anthropomorphic phantom loaded with TLD detectors. Summarizing our results, we can conclude that low energy radiation techniques, namely VMAT and Tomotherapy, have more interesting performances when compared to IMRT at energies of 10 MV and 18 MV, with respect to peripheral dose. On the one hand the former are associated with lower photon doses and, on the other hand, there is no contribution from neutrons to the total dose. -- Highlights: •We measured peripheral doses in prostate and head and neck cancer. •We performed measurements on IMRT, tomotherapy and VMAT. •We measured photon and neutrons doses, using TLD and bubble detectors, respectively. •Results have shown a significant neutrons contribution at 18 MV

  12. Carbon Ion Radiotherapy for Peripheral Stage I Non-Small Cell Lung Cancer

    Science.gov (United States)

    Kamada, Tadashi; Yamamoto, Naoyoshi; Baba, Masayuki

    The National Institute of Radiological Sciences in Chiba, Japan (NIRS) has the highest number of patients with lung cancer treated with carbon ion beams in the world. This report describes the techniques and clinical trials that have been undertaken at NIRS and preliminary results of a current study on single-fraction irradiation. The data are compared to recent results for the treatment of peripheral stage I lung cancer from the literature.

  13. Evaluation of the peripheral dose in stereotactic radiotherapy and radiosurgery treatments

    Energy Technology Data Exchange (ETDEWEB)

    Di Betta, Erika; Fariselli, Laura; Bergantin, Achille; Locatelli, Federica; Del Vecchio, Antonella; Broggi, Sara; Fumagalli, Maria Luisa [Department of Neurosurgery, Division of Medical Physics, Fondazione IRCCS, Istituto Neurologico C. Besta, 20133 Milano (Italy); Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS, Istituto Neurologico C. Besta, 20133 Milano (Italy); CyberKnife Centre, Centro Diagnostico Italiano, 20147 Milano (Italy); Division of Medical Physics, Fondazione IRCCS, Istituto S. Raffaele, 20132 Milano (Italy); Department of Neurosurgery, Division of Medical Physics, Fondazione IRCCS, Istituto Neurologico C. Besta, 20133 Milano (Italy)

    2010-07-15

    Purpose: The main purpose of this work was to compare peripheral doses absorbed during stereotactic treatment of a brain lesion delivered using different devices. These data were used to estimate the risk of stochastic effects. Methods: Treatment plans were created for an anthropomorphic phantom and delivered using a LINAC with stereotactic cones and a multileaf collimator, a CyberKnife system (before and after a supplemental shielding was applied), a TomoTherapy system, and a Gamma Knife unit. For each treatment, 5 Gy were prescribed to the target. Measurements were performed with thermoluminescent dosimeters inserted roughly in the position of the thyroid, sternum, upper lung, lower lung, and gonads. Results: Mean doses ranged from of 4.1 (Gamma Knife) to 62.8 mGy (LINAC with cones) in the thyroid, from 2.3 (TomoTherapy) to 30 mGy (preshielding CyberKnife) in the sternum, from 1.7 (TomoTherapy) to 20 mGy (preshielding CyberKnife) in the upper part of the lungs, from 0.98 (Gamma Knife) to 15 mGy (preshielding CyberKnife) in the lower part of the lungs, and between 0.3 (Gamma Knife) and 10 mGy (preshielding CyberKnife) in the gonads. Conclusions: The peripheral dose absorbed in the sites of interest with a 5 Gy fraction is low. Although the risk of adverse side effects calculated for 20 Gy delivered in 5 Gy fractions is negligible, in the interest of optimum patient radioprotection, further studies are needed to determine the weight of each contributor to the peripheral dose.

  14. Evaluation of the peripheral dose in stereotactic radiotherapy and radiosurgery treatments

    International Nuclear Information System (INIS)

    Purpose: The main purpose of this work was to compare peripheral doses absorbed during stereotactic treatment of a brain lesion delivered using different devices. These data were used to estimate the risk of stochastic effects. Methods: Treatment plans were created for an anthropomorphic phantom and delivered using a LINAC with stereotactic cones and a multileaf collimator, a CyberKnife system (before and after a supplemental shielding was applied), a TomoTherapy system, and a Gamma Knife unit. For each treatment, 5 Gy were prescribed to the target. Measurements were performed with thermoluminescent dosimeters inserted roughly in the position of the thyroid, sternum, upper lung, lower lung, and gonads. Results: Mean doses ranged from of 4.1 (Gamma Knife) to 62.8 mGy (LINAC with cones) in the thyroid, from 2.3 (TomoTherapy) to 30 mGy (preshielding CyberKnife) in the sternum, from 1.7 (TomoTherapy) to 20 mGy (preshielding CyberKnife) in the upper part of the lungs, from 0.98 (Gamma Knife) to 15 mGy (preshielding CyberKnife) in the lower part of the lungs, and between 0.3 (Gamma Knife) and 10 mGy (preshielding CyberKnife) in the gonads. Conclusions: The peripheral dose absorbed in the sites of interest with a 5 Gy fraction is low. Although the risk of adverse side effects calculated for 20 Gy delivered in 5 Gy fractions is negligible, in the interest of optimum patient radioprotection, further studies are needed to determine the weight of each contributor to the peripheral dose.

  15. Evaluation of the peripheral dose in stereotactic radiotherapy and radiosurgery treatments1

    Science.gov (United States)

    Di Betta, Erika; Fariselli, Laura; Bergantin, Achille; Locatelli, Federica; Del Vecchio, Antonella; Broggi, Sara; Fumagalli, Maria Luisa

    2010-01-01

    Purpose: The main purpose of this work was to compare peripheral doses absorbed during stereotactic treatment of a brain lesion delivered using different devices. These data were used to estimate the risk of stochastic effects. Methods: Treatment plans were created for an anthropomorphic phantom and delivered using a LINAC with stereotactic cones and a multileaf collimator, a CyberKnife® system (before and after a supplemental shielding was applied), a TomoTherapy® system, and a Gamma Knife® unit. For each treatment, 5 Gy were prescribed to the target. Measurements were performed with thermoluminescent dosimeters inserted roughly in the position of the thyroid, sternum, upper lung, lower lung, and gonads. Results: Mean doses ranged from of 4.1 (Gamma Knife) to 62.8 mGy (LINAC with cones) in the thyroid, from 2.3 (TomoTherapy) to 30 mGy (preshielding CyberKnife) in the sternum, from 1.7 (TomoTherapy) to 20 mGy (preshielding CyberKnife) in the upper part of the lungs, from 0.98 (Gamma Knife) to 15 mGy (preshielding CyberKnife) in the lower part of the lungs, and between 0.3 (Gamma Knife) and 10 mGy (preshielding CyberKnife) in the gonads. Conclusions: The peripheral dose absorbed in the sites of interest with a 5 Gy fraction is low. Although the risk of adverse side effects calculated for 20 Gy delivered in 5 Gy fractions is negligible, in the interest of optimum patient radioprotection, further studies are needed to determine the weight of each contributor to the peripheral dose. PMID:20831066

  16. Radiotherapy

    International Nuclear Information System (INIS)

    The need for radiotherapy research is exemplified by the 100,000 cancer patients who will fail treatment locally and/or regionally annually for the next several years but who would benefit from better local treatment modalities. Theoretically, all of the areas of investigation discussed in this projection paper have the potential to significantly improve local-regional treatment of cancer by radiotherapy alone or in combination with other modalities. In many of the areas of investigation discussed in this paper encouraging results have been obtained in cellular and animal tumor studies and in limited studies in humans as well. In the not too distant future the number of patients who would benefit from better local control may increase by tens of thousands if developments in chemotherapy and/or immunotherapy provide a means to eradicate disseminated microscopic foci of cancer. Thus the efforts to improve local-regional control take on even greater significance

  17. Peripheral dose measurements in cervical cancer radiotherapy: a comparison of volumetric modulated arc therapy and step-and-shoot IMRT techniques

    International Nuclear Information System (INIS)

    The aim of this study was to investigate the peripheral doses resulting from volumetric modulated arc therapy (VMAT) and intensity modulated radiotherapy (IMRT) techniques in cervical cancer radiotherapy. Nine patients with cervical cancer had treatment planned with both VMAT and IMRT. A specially designed phantom was used for this study, with ion chambers placed at interest points approximating the position of the breast, thyroid, and lens. The peripheral doses at the phantom interest points were measured and compared between the VMAT and IMRT techniques. VMAT provides a potential dosimetric advantage compared with IMRT. The mean (± standard deviation) peripheral dose to the breast point for 1 fraction (2 Gy) during VMAT measured 5.13 ± 0.96 mGy, compared with 9.04 ± 1.50 mGy for IMRT. At the thyroid and lens interest points, the mean (± standard deviation) peripheral dose during VMAT was 2.19 ± 0.33 and 2.16 ± 0.28 mGy, compared with 7.07 ± 0.76 and 6.97 ± 0.91 mGy for IMRT, respectively. VMAT reduced the monitor units used by 28% and shortened the treatment delivery time by 54% compared with IMRT. While the dosimetric results are similar for both techniques, VMAT results in a lower peripheral dose to the patient and reduces the monitor-unit usage and treatment delivery time compared with IMRT

  18. Differences in pulmonary function before vs. 1 year after hypofractionated stereotactic radiotherapy for small peripheral lung tumors

    International Nuclear Information System (INIS)

    Purpose: To evaluate long-term pulmonary toxicity of stereotactic radiotherapy (SRT) by pulmonary function tests (PFTs) performed before and after SRT for small peripheral lung tumors. Methods and Materials: A total of 17 lesions in 15 patients with small peripheral lung tumors, who underwent SRT between February 2000 and April 2003, were included in this study. Twelve patients had primary lung cancer, and 3 patients had metastatic lung cancer. Primary lung cancer was T1-2N0M0 in all cases. Smoking history was assessed by the Brinkman index (number of cigarettes smoked per day multiplied by number of years of smoking). Prescribed radiation doses at the 80% isodose line were 40-60 Gy in 5-8 fractions. PFTs were performed immediately before SRT and 1 year after SRT. Test parameters included total lung capacity (TLC), vital capacity (VC), forced expiratory volume in 1 s (FEV1.0), and diffusing capacity of lung for carbon monoxide (DLCO). PFT changes were evaluated in relation to patient- and treatment-related factors, including age, the Brinkman index, internal target volume, the percentages of lung volume irradiated with >15, 20, 25, and 30 Gy (V15, V20, V25, and V30, respectively), and mean lung dose. Results: There were no significant changes in TLC, VC, or FEV1.0 before vs. after SRT. The mean percent change from baseline in DLCO was significantly increased by 128.2%. Univariate and multivariate analyses revealed a correlation between DLCO and the Brinkman index. Conclusions: One year after SRT as compared with before SRT, there were no declines in TLC, VC, and FEV1.0. DLCO improved in patients who had been heavy smokers before SRT, suggesting a correlation between DLCO and smoking cessation. SRT seems to be tolerable in view of long-term lung function

  19. Antiprotonic-hydrogen atoms

    International Nuclear Information System (INIS)

    Experimental studies of antiprotonic-hydrogen atoms have recently made great progress following the commissioning of the low energy antiproton facility (LEAR) at CERN in 1983. At the same time our understanding of the atomic cascade has increased considerably through measurements of the X-ray spectra. The life history of the p-bar-p atom is considered in some detail, from the initial capture of the antiproton when stopping in hydrogen, through the atomic cascade with the emission of X-rays, to the final antiproton annihilation and production of mesons. The experiments carried out at LEAR are described and the results compared with atomic cascade calculations and predictions of strong interaction effects. (author)

  20. Nuclear physics with antiprotons

    International Nuclear Information System (INIS)

    The use of antiproton beams in Nuclear Physics has been until now limited to a few total and reaction cross section measurements and to the study of antiprotonic atoms. This situation is presently about to change with the advent of the low Energy Antiproton Ring ''LEAR'' at CERN which started to deliver antiprotons for Physics experiments in July 1983. But what can we learn from Nuclear Physics with antiprotons. To answer this question I will first review basic and simple features of the low energy antiN-N interaction and their energy dependence. I will show that the antiproton is an interesting probe to explore the nucleus and bring informations complementary to that already provided by the other usual probe like e, p, π, α particles etc... I will in turn point out a few points that make a nucleus a very useful laboratory to study the antiN-N elementary interaction and get informations that are not available in the free antiN-N interaction

  1. Interaction of antiprotons with nuclei

    Czech Academy of Sciences Publication Activity Database

    Hrtánková, Jaroslava; Mareš, Jiří

    2016-01-01

    Roč. 945, JAN (2016), s. 197-215. ISSN 0375-9474 R&D Projects: GA ČR(CZ) GA15-04301S Institutional support: RVO:61389005 Keywords : antiproton-nucleus interaction * antiproton annihilation * antiproton nuclear bound states Subject RIV: BE - Theoretical Physics Impact factor: 2.202, year: 2014

  2. Cancer Therapy with Antiprotons

    Science.gov (United States)

    Bassler, Niels; Holzscheiter, Michael H.; Ad-4 Collaboration

    2005-10-01

    Starting in 2003 the AD-4/ACE collaboration has studied the biological effects of antiprotons annihilating in a human tissue like material on live V-79 Chinese Hamster cells. The main goal of the work is to prove the efficacy of antiprotons for cancer therapy. In this report we discuss a critical point to be considered carefully for all particle beam radiation therapies, namely the loss of primary particles from the beam on the way to a tumor seated some distance below the surface.

  3. Peripheral doses in modulated intensive radiotherapy (MIRT) and its implications in radiological protection; Dosis periferica en radioterapia de intensidad modulada (IMRT) y su implicancia en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Cobos, Agustin C.; Sanz, Dario E.; Alvarez, Guilhermo D., E-mail: cletocobos@hotmail.com, E-mail: dsanz@fuesmen.edu.ar, E-mail: galvarez@fuesmen.edu.ar [Fundacion Escuela de Medicina Nuclear (FUESMEN), Mendonza (Argentina)

    2013-07-01

    A calculation model based on the theory of photon transport, to estimate the peripheral energy fluence (fluence occurring outside the radiation beam) produced by the dispersions of photon compensating filters used was developed in IMRT mode, in a treatment room radiotherapy service of FUESMEN. In order to validate the model were experimentally determined fluences and peripheral dose for three different sizes of compensating filters. It was found that there is a slight systematic overestimation model with respect to experimental results. The experimental values also allowed the comparison of the peripheral doses with other modalities. Furthermore, a model was developed to estimate the annual dose that occurs at any point to be protected with a shield, from the theoretical values obtained from peripheral energy flow. Using the theoretical values automatically allowed to take a conservative approach because of the slight overestimation already mentioned, the couple have a calculation model for widespread use. It was found that the contribution of the peripheral dose to the annual dose is more than significant, thus suggesting that the same should be considered in the design calculations of secondary barriers.

  4. Biological effectiveness of antiproton annihilation

    CERN Document Server

    Holzscheiter, Michael H.; Bassler, Niels; Beyer, Gerd; De Marco, John J.; Doser, Michael; Ichioka, Toshiyasu; Iwamoto, Keisuke S.; Knudsen, Helge V.; Landua, Rolf; Maggiore, Carl; McBride, William H.; Møller, Søren Pape; Petersen, Jorgen; Smathers, James B.; Skarsgard, Lloyd D.; Solberg, Timothy D.; Uggerhøj, Ulrik I.; Withers, H.Rodney; Vranjes, Sanja; Wong, Michelle; Wouters, Bradly G.

    2004-01-01

    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in “biological dose” in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

  5. Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients

    OpenAIRE

    Napolitano, Maria; D'Alterio, Crescenzo; Cardone, Eleonora; Trotta, Anna Maria; Pecori, Biagio; Rega, Daniela; PACE, UGO; Scala, Dario; Scognamiglio, Giosuè; Tatangelo, Fabiana; Cacciapuoti, Carmela; Pacelli, Roberto; Delrio, Paolo; Scala, Stefania

    2015-01-01

    Short-course preoperative radiotherapy (SC-RT) followed by total mesorectal excision (TME) is one therapeutic option for locally advanced rectal cancer (LARC) patients. Since radio-induced DNA damage may affect tumor immunogenicity, Myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs) were evaluated in 13 patients undergoing SC-RT and TME for LARC. Peripheral Granulocytic-MDSCs (G-MDSC) [LIN−/HLA-DR−/CD11b+/CD14−/CD15+/CD33+], Monocytic (M-MDSC) [CD14+/HLA-DR−/lowCD11b+/CD3...

  6. Peripheral dose from neutrons and photons in the radiation treatment of pelvic tumors with conventional technique or VMAT. A review; Periphere Neutronen- und Photonendosis bei der Radiotherapie von Tumoren des Beckens mit konventioneller Technik oder VMAT. Eine Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, P. [Medizinische Univ. Graz (Austria). Comprehensive Cancer Center

    2015-07-01

    Peripheral neutron and photon doses from external beam radiation therapy are associated with the risk of carcinogenesis in organs distant to the treated volume. In the irradiation of tumors and target volumes in the pelvis with convention photon-radiotherapy beams with high nominal energies (above 15 MeV) are typically used. During the last years volumetric modulated arc therapy (VMAT) techniques have gained a wide-spread use for pelvic treatments. The beam-energies that are primarily used in VMAT are below 10 MeV. Therefore, a reduction in peripheral dose due to the absence of neutrons can be expected when VMAT is utilized. On the other hand the number of monitor units is increased in increased in VMAT, as compared to conventional unmodulated fields, by a factor of two to three. This leads to an increase in transmission dose from the machine's treatment head, such that the potential benefit might be outbalanced. The question, whether the increasing use of VMAT might lead to a reduction of peripheral dose, is the subject of several studies. Those studies use either measurements in phantom settings or Monte-Carlo simulations. A systematic review of the literature shows diverging, and sometimes even contradictory, findings. Therefore, the issue of peripheral dose and the risk for secondary malignancies requires further investigation. In our opinion, the focus should be put on measurements and simulations, but also on modelling of dose-response correlations.

  7. Antiprotons are another matter

    International Nuclear Information System (INIS)

    Theories of gravity abound, whereas experiments in gravity are few in number. An important experiment in gravity that has not been performed is the measurement of the gravitational acceleration of antimatter. Although there have been attempts to infer these properties from those of normal matter, none of these theoretical arguments are compelling. Modern theories of gravity that attempt to unify gravity with the other forces of nature predict that in principle antimatter can fall differently than normal matter in the Earth's field. Some of these supergravity theories predict that antimatter will fall faster, and that normal matter will fall with a small Baryon-number dependance in the earth's field. All of these predictions violate the Weak Equivalence Principle, a cornerstone of General Relativity, but are consistent with CPT conservation. In our approved experiment at LEAR (PS-200) we will test the Weak Equivalence Principle for antimatter by measuring the gravitational acceleration of the antiproton. Through a series of deceleration stages, antiprotons from LEAR will be lowered in energy to ∼4 Kelvin at which energy the gravitational effect will be measureable. The measurement will employ the time-of-flight technique wherein the antiprotons are released vertically in a drift tube. The spectrum of time-of-flight measurements can be used to extract the gravitational acceleration experienced by the particles. The system will be calibrated using H- ions which simulates the electromagnetic behavior of the antiproton, yet is a baryon to ∼0.1%. To extract the gravitational acceleration of the antiproton relative to the H- ion with a statistical precision of 1% will require the release of ∼106 to 107 particles

  8. Antiproton-nucleus interaction

    Science.gov (United States)

    Cugnon, J.; Vandermeulen, J.

    The antiproton-nucleus physics is reviewed. On the experimental side, the recent results obtained at the LEAR, BNL and KEK facilities are analyzed. A brief summary of the main pp and pn experimental data is also given. The antiproton-nucleus interaction can lead to elasic, inelastic and charge exchange scattering and to annihilation. The latter is very dominant. The scattering cross-sections are usually analyzed in terms of complex potential models. The relationship between potentials, charge conjugation and Dirac phenomenology is discussed. Much emphasis is put on the dynamics of the antiproton annihilation on nuclei. The energy transfer, pion absorption and target response are analyzed within the intranuclear cascade model. Special interest is devoted to strangeness production, hypernucleus formation and possible annihilation on two nucleons. Signatures for this new process are searched in experimental data. Finally, the highly debated question of quark-gluon formation is analyzed. Cet article constitue une revue de la physique antiproton-noyau. Du point de vue expérimental, cette revue porte particulièrement sur les récents résultats obtenus à LEAR, BNL et KEK. On y a aussi inclus une mise à jour des faits expérimentaux principaux pour pp et pn. L'interaction antiproton-noyau conduit à la diffusion élastique, inélastique et d'xA9change de charge et à des processus d'annihilation. Habituellement, les expériences de diffusion sont analysées en termes de potentiels complexes. La relation entre ces potentiels, la conjugaison de charge et la phénoménologie de Dirac est discutée. On s'est particulièrement intéressé à la dynamique de l'annihilation d'antiprotons sur des noyaux. Le transfert d'énergie, l'absorption de pions et la réponse de la cible sont analysés dans le cadre du modèle de cascade intranucléaire. Certains autres points sont discutés plus en détail: la production d'étrangeté, la formation d'hypernoyaux et l'annihilation sur

  9. Depth-Dose and LET Distributions of Antiproton Beams in Various Target Materials

    DEFF Research Database (Denmark)

    Herrmann, Rochus; Olsen, Sune; Petersen, Jørgen B.B.;

    Purpose  Radiotherapy with antiprotons is still being investigated as a possible new beam modality. Antiprotons behave much like protons until they come to rest, where they will annihilate with a target nucleus, thereby releasing additional energy. This can potentially lead to a favourable  depth...... change in the depth-dose distribution and average LET when substituting the materials. Adding boron and gadolinium up to concentrations of 1 per 1000 atoms to a water phantom, did not change the depth-dose profile nor the average LET. Conclusions  According to our FLUKA calculations, antiproton neutron...

  10. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy; Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero

    Energy Technology Data Exchange (ETDEWEB)

    Magnata, Simey de Souza Leao Pereira

    2002-09-01

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of {sup 69} Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  11. Calculated LET spectrum from antiproton beams stopping in water

    CERN Document Server

    Bassler, Niels

    2009-01-01

    Antiprotons have been proposed as a potential modality for radiotherapy because the annihilation at the end of range leads to roughly a doubling of physical dose in the Bragg peak region. So far it has been anticipated that the radiobiology of antiproton beams is similar to that of protons in the entry region of the beam, but very different in the annihilation region, due to the expected high-LET components resulting from the annihilation. On closer inspection we find that calculations of dose averaged LET in the entry region may suggest that the RBE of antiprotons in the plateau region could significantly differ from unity, which seems to warrant closer inspection of the radiobiology in this region. Materials and Methods. Monte Carlo simulations using FLUKA were performed for calculating the entire particle spectrum of a beam of 126 MeV antiprotons hitting a water phantom. Results and Discussion. In the plateau region of the simulated antiproton beam we observe a dose-averaged unrestrict...

  12. Primary population of antiprotonic helium states

    OpenAIRE

    Révai, J.; Shevchenko, N.V.(Nuclear Physics Institute, Řež, 25068, Czech Republic)

    2003-01-01

    A full quantum mechanical calculation of partial cross-sections leading to different final states of antiprotonic helium atom was performed. Calculations were carried out for a wide range of antiprotonic helium states and incident (lab) energies of the antiproton.

  13. Bubble chamber: antiproton annihilation

    CERN Multimedia

    1971-01-01

    These images show real particle tracks from the annihilation of an antiproton in the 80 cm Saclay liquid hydrogen bubble chamber. A negative kaon and a neutral kaon are produced in this process, as well as a positive pion. The invention of bubble chambers in 1952 revolutionized the field of particle physics, allowing real tracks left by particles to be seen and photographed by expanding liquid that had been heated to boiling point.

  14. Extra Low ENergy Antiproton

    CERN Multimedia

    To produce dense antiproton beams at very low energies (110 keV), it has been proposed to install a small decelerator ring between the existing AD ring and the experimental area. Phase-space blowup during deceleration is compensated by electron cooling such that the final emittances are comparable to the 5MeV beam presently delivered by the AD. An immediate consequence is a significant increase in the number of trapped antiprotons at the experiments as outlined in the proposal CERN/SPSC-2009-026; SPCS-P-338. This report describes the machine parameters and layout of the proposal ELENA (Extra Low ENergy Antiproton)ring also gives an approximate estimate of cost and manpower needs. Since the initial estimate, published in 2007 (CERN-AB-2007-079), the ELENA design has evolved considerably. This is due to a new location in the AD hall to acommodate for the possibility of another experimental zone, as suggested by the SPCS, and also due to improvements in the ring optics and layout. The cost estimate that is prese...

  15. ALPHA freezes antiprotons

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Laboratories like CERN can routinely produce many different types of antiparticles. In 1995, the PS210 experiment formed the first antihydrogen atoms and a few years later, in 2002, ATRAP and ATHENA were already able to produce several thousand of them. However, no experiment in the world has succeeded in ‘trapping’ these anti-atoms in order to study them. This is the goal of the ALPHA experiment, which has recently managed to cool down the antiprotons to just a few Kelvin. This represents a major step towards trapping the anti-atom, thus opening a new avenue into the investigation of antimatter properties.   Members of the ALPHA collaboration working on the apparatus in the Antiproton Decelerator experimental hall at CERN. Just like the atom, the anti-atom is neutral. Unlike the atom, the anti-atom is made up of antiprotons (as opposed to protons in the atom) and positrons (as opposed to electrons). In order to thoroughly study the properties of the anti-atoms, scien...

  16. Antiproton compression and radial measurements

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Funakoshi, R; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jenkins, M J; Jorgensen, L V; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Page R D; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; Van der Werf, D P; Wurtele, J S; Yamazaki, Y

    2008-01-01

    Control of the radial profile of trapped antiproton clouds is critical to trapping antihydrogen. We report detailed measurements of the radial manipulation of antiproton clouds, including areal density compressions by factors as large as ten, achieved by manipulating spatially overlapped electron plasmas. We show detailed measurements of the near-axis antiproton radial profile, and its relation to that of the electron plasma. We also measure the outer radial profile by ejecting antiprotons to the trap wall using an octupole magnet.

  17. Biological effectiveness of antiproton annihilation

    DEFF Research Database (Denmark)

    Holzscheiter, M.H.; Agazaryan, N.; Bassler, Niels;

    2004-01-01

    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct...

  18. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

  19. Low energy antiproton physics

    International Nuclear Information System (INIS)

    This paper summarizes the present experimental and theoretical status of antinucleon-nucleon (bar NN) interactions at low energy (below 2 GeV/c). The authors discuss elastic scattering, hyperon pair production, and annihilation into mesonic channels, including the search for exotic meson states in the annihilation debris. New results from the Low Energy Antiproton Ring (LEAR) at CERN, from KEK in Japan, and from Brookhaven National Laboratory (BNL) are now available. Some of the experiments and their comparison to theoretical predictions have been reviewed earlier. The authors extend these reviews to more recent data and theoretical calculations

  20. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling. In this picture, the 26 GeV high-intensity beam from the PS enters from the right, where a scintillator screen, with circles every 5 mm in radius, permits precise aim at the target centre. See also 7903034 and 7905094.

  1. Treatment Plans for Antiproton Beams

    DEFF Research Database (Denmark)

    Holzscheiter, Michael; Bassler, Niels; Herrmann, Rochus;

    Antiprotons have been proposed as potential modality for particle beam cancer therapy by Gray and Kalogeropoulos in 1985. This proposal was based on the enhancement of physical dose deposition near the end of range due to the annihilation of antiprotons when captured by a nucleus and the expectat......Antiprotons have been proposed as potential modality for particle beam cancer therapy by Gray and Kalogeropoulos in 1985. This proposal was based on the enhancement of physical dose deposition near the end of range due to the annihilation of antiprotons when captured by a nucleus and the...... expectation of an enhanced RBE of this additional dose. Starting in 2003 the AD-4 collaboration at CERN has studied biological effects of antiproton beams on V79 Chinese Hamster cells and human FaDu cells. The AD-4 collaboration has developed relative and absolute dosimetry for pulsed antiproton beams. Data...... from these measurements were used to benchmark the FLUKA Monte Carlo code, which then has been used for calculations of physical dose inside and outside of the primary antiproton beam. From clonogenic survival studies on the different cell lines mentioned above we have determined biological effective...

  2. A reservoir trap for antiprotons

    CERN Document Server

    Smorra, Christian; Franke, Kurt; Nagahama, Hiroki; Schneider, Georg; Higuchi, Takashi; Van Gorp, Simon; Blaum, Klaus; Matsuda, Yasuyuki; Quint, Wolfgang; Walz, Jochen; Yamazaki, Yasunori; Ulmer, Stefan

    2015-01-01

    We have developed techniques to extract arbitrary fractions of antiprotons from an accumulated reservoir, and to inject them into a Penning-trap system for high-precision measurements. In our trap-system antiproton storage times > 1.08 years are estimated. The device is fail-safe against power-cuts of up to 10 hours. This makes our planned comparisons of the fundamental properties of protons and antiprotons independent from accelerator cycles, and will enable us to perform experiments during long accelerator shutdown periods when background magnetic noise is low. The demonstrated scheme has the potential to be applied in many other precision Penning trap experiments dealing with exotic particles.

  3. Proton-antiproton collider physics

    CERN Document Server

    Altarelli, Guido

    1989-01-01

    This volume reviews the physics studied at the CERN proton-antiproton collider during its first phase of operation, from the first physics run in 1981 to the last one at the end of 1985. The volume consists of a series of review articles written by physicists who are actively involved with the collider research program. The first article describes the proton-antiproton collider facility itself, including the antiproton source and its principle of operation based on stochastic cooling. The subsequent six articles deal with the various physics subjects studied at the collider. Each article descr

  4. The Antiproton Accumulator (AA)

    CERN Multimedia

    1980-01-01

    Section 06 - 08*) of the AA where the dispersion (and hence the horizontal beam size) is large. One can distinguish (left to right): A vacuum-tank, two bending magnets (BST06 and BST07 in blue) with a quadrupole (QDN07, in red) in between, another vacuum-tank, a wide quadrupole (QFW08) and a further tank . The tanks are covered with heating tape for bake-out. The tank left of BST06 contained the stack core pickup for stochastic cooling (see 7906193, 7906190, 8005051), the two other tanks served mainly as vacuum chambers in the region where the beam was large. Peter Zettwoch works on BST06. *) see: H. Koziol, Antiproton Accumulator Parameter List, PS/AA/Note 84-2 (1984)

  5. Antiproton Star Observed in Emulsion

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlain, Owen; Chupp, Warren W.; Goldhaber, Gerson; Segre,Emilio; Wiegand, Clyde; Amaldi, E.; Baroni, G.; Castagnoli, C.; Franzinetti, C.; Manfredini, A.

    1955-12-01

    In connection with the antiproton investigation at the Bevatron we planned and carried out a photographic-emulsion exposure in a magnetically selected beam of negative particles. The magnetic system was identical to the first half (one deflecting magnet and one magnetic lens) of the system used in the antiproton experiment of Chamberlain, Segre, Wiegand, and Ypsilantis. The selected particles left the copper target in the forward direction with momentum 1.09 Bev/c.

  6. Comparison of electromagnetic and hadronic models generated using Geant 4 with antiproton dose measured in CERN

    Directory of Open Access Journals (Sweden)

    Mohammad Bagher Tavakoli

    2015-01-01

    Full Text Available After proposing the idea of antiproton cancer treatment in 1984 many experiments were launched to investigate different aspects of physical and radiobiological properties of antiproton, which came from its annihilation reactions. One of these experiments has been done at the European Organization for Nuclear Research known as CERN using the antiproton decelerator. The ultimate goal of this experiment was to assess the dosimetric and radiobiological properties of beams of antiprotons in order to estimate the suitability of antiprotons for radiotherapy. One difficulty on this way was the unavailability of antiproton beam in CERN for a long time, so the verification of Monte Carlo codes to simulate antiproton depth dose could be useful. Among available simulation codes, Geant4 provides acceptable flexibility and extensibility, which progressively lead to the development of novel Geant4 applications in research domains, especially modeling the biological effects of ionizing radiation at the sub-cellular scale. In this study, the depth dose corresponding to CERN antiproton beam energy by Geant4 recruiting all the standard physics lists currently available and benchmarked for other use cases were calculated. Overall, none of the standard physics lists was able to draw the antiproton percentage depth dose. Although, with some models our results were promising, the Bragg peak level remained as the point of concern for our study. It is concluded that the Bertini model with high precision neutron tracking (QGSP_BERT_HP is the best to match the experimental data though it is also the slowest model to simulate events among the physics lists.

  7. Antiproton Cancer Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels

    An essential part in cancer radiotherapy, is to direct a sufficiently high dose towards the tumour, without damaging the surrounding tissue. Different techniques such as intensity modulated radiation therapy and proton therapy have been developed, in order to reduce the dose to the normal tissue...

  8. Antiproton production at 0 degrees for Si + A and Au + A collisions at the AGS

    International Nuclear Information System (INIS)

    We present results on antiproton production obtained in the AGS experiments E858 and preliminary results of E878. The yields of antiprotons in Si + A collisions are shown to sale with number of first collisions. The rapidity distributions for all targets (Au, Cu and Al) and both beams (si at 14.6 GeV/c and A at 11. GeV/c) have gaussian shapes peaking at yNN and with similar standard deviations. From E878 we report a difference in the shape of the antiproton rapidity distributions obtained from two samples of the data populated with central and peripheral events respectively. In A induced reactions the A dependence of the antiproton yields is small

  9. Comparison of pencil beam–based homogeneous vs inhomogeneous target dose planning for stereotactic body radiotherapy of peripheral lung tumors through Monte Carlo–based recalculation

    Energy Technology Data Exchange (ETDEWEB)

    Ohtakara, Kazuhiro, E-mail: ohtakara@murakami.asahi-u.ac.jp [Department of Radiation Oncology, Murakami Memorial Hospital, Asahi University, Gifu (Japan); Hoshi, Hiroaki [Department of Radiology, Gifu University Graduate School of Medicine, Gifu (Japan)

    2015-10-01

    This study was conducted to ascertain whether homogeneous target dose planning is suitable for stereotactic body radiotherapy (SBRT) of peripheral lung cancer under appropriate breath-holding. For 20 peripheral lung tumors, paired dynamic conformal arc plans were generated by only adjusting the leaf margin to the planning target volume (PTV) edge for fulfilling the conditions such that the prescription isodose surface (IDS) encompassing exactly 95% of the PTV (PTV D{sub 95}) corresponds to 95% and 80% IDS, normalized to 100% at the PTV isocenter under a pencil beam (PB) algorithm with radiologic path length correction. These plans were recalculated using the x-ray voxel Monte Carlo (XVMC) algorithm under otherwise identical conditions, and then compared. Lesions abutting the parietal pleura or not were defined as edge or island tumors, respectively, and the influences of the target volume and its location relative to the chest wall on the target dose were examined. The median (range) leaf margin required for the 95% and 80% plans was 3.9 mm (1.3 to 5.0) and −1.2 mm (−1.8 to 0.1), respectively. Notably, the latter was significantly correlated negatively with PTV. In the 80% plans, the PTV D{sub 95} was slightly higher under XVMC, whereas the PTV D{sub 98} was significantly lower, irrespective of the dose calculation algorithm used. Other PTV and all gross tumor volume doses were significantly higher, while the lung doses outside the PTV were slightly lower. The target doses increased as a function of PTV and were significantly lower for island tumors than for edge tumors. In conclusion, inhomogeneous target dose planning using smaller leaf margin for a larger tumor volume was deemed suitable in ensuring more sufficient target dose while slightly reducing lung dose. In addition, more inhomogeneous target dose planning using <80% IDS (e.g., 70%) for PTV covering would be preferable for island tumors.

  10. The Antiproton Accumulator (AA)

    CERN Multimedia

    1980-01-01

    A section of the AA where the dispersion (and hence the horizontal beam size) is large. One can distinguish (left to right): A large vacuum-tank, a quadrupole (QDN09*), a bending magnet (BST08), another vacuum-tank, a wide quadrupole (QFW08) and (in the background) a further bending magnet (BST08). The tanks are covered with heating tape for bake-out. The tank left of QDN09 contained the kickers for stochastic pre-cooling (see 790621, 8002234, 8002637X), the other one served mainly as vacuum chamber in the region where the beam was large. Peter Zettwoch works on QFW08. * see: H. Koziol, Antiproton Accumulator Parameter List, PS/AA/Note 84-2 (1984) See under 7911303, 7911597X, 8004261 and 8202324. For photos of the AA in different phases of completion (between 1979 and 1982) see: 7911303, 7911597X, 8004261, 8004608X, 8005563X, 8005565X, 8006716X, 8006722X, 8010939X, 8010941X, 8202324, 8202658X, 8203628X .

  11. Antiprotonic helium atomcules

    Directory of Open Access Journals (Sweden)

    Sauge Sébastien

    2012-10-01

    Full Text Available About 3% of antiprotons ( stopped in helium are long-lived with microsecond lifetimes, against picoseconds in all other materials. This unusual longevity has been ascribed to the trapping of on metastable bound states in He+ helium atom-molecules thus named atomcules. Apart from their unique dual structure investigated by laser spectroscopy – a near-circular quasi-classical Rydberg atom with l ~ n – 1 ~ 37 or a special diatomic molecule with a negatively charged nucleus in high rotational state with J = l – the chemical physics aspects of their interaction with other atoms or molecules constitute an interesting topic for molecular physics. While atomcules may resist to million collisions in helium, molecular contaminants such as H2 are likely to destroy them in a single one, down to very low temperatures. In the Born-Oppenheimer framework, we interpret the molecular interaction obtained by ab initio quantum chemical calculations in terms of classical reactive channels, with activation barriers accounting for the experiments carried out in He and H2. From classical trajectory Monte Carlo simulations, we show that the thermalization stage strongly quenches initial populations, thus reduced to a recovered 3 % trapping fraction. This work illustrates the pertinence of chemical physics concepts to the study of exotic processes involving antimatter. New insights into the physico-chemistry of cold interstellar radicals are anticipated.

  12. Remote antiproton sources

    International Nuclear Information System (INIS)

    Antiprotons are well on their way to becoming a standard laboratory commodity. Heavy utilization of LEAR is ushering in a new era where p's achieve their logical potential, equal to that of e-,e+,H-, as controlled probes and experimental building blocks. The uniqueness and usefulness of - /SUB p/ 's for studies at low (table top) energies is well documented. The main stumbling block to universal pursuit of such studies is the overhead of - /SUB p/ production. The stability of the - /SUB p/ thus makes cogent an investigation of possibilities and limits to transporting - /SUB p/ 's in quantity. I base my discussion on LEAR as the source of - /SUB p/ 's for bottling, since it is the only concrete example to work with at present. Two other lines of contemporary research then, largely in atomic physics, pioneered by Dehmelt and collaborators, aimed at precision studies of clouds of, or single e /SUP +or-/ ,p /SUP +or-/ , or ions in large storage time traps. Second, there is work, experimental and theoretical, from the plasma physics tradition aimed at characterizing non neutral plasmas

  13. Capture of slow antiprotons by helium atoms

    OpenAIRE

    Revai, J.; Shevchenko, N.V.(Nuclear Physics Institute, Řež, 25068, Czech Republic)

    2004-01-01

    A consistent quantum mechanical calculation of partial cross-sections leading to different final states of antiprotonic helium atom was performed. For the four-body scattering wave function, corresponding to the initial state, as well as for the antiprotonic helium wave function, appearing in the final tate, adiabatic approximations was used. Calculations were carried out for a wide range of antiprotonic helium states and incident energies of the antiproton. Obtained energy dependances of som...

  14. Assessment of Monte Carlo algorithm for compliance with RTOG 0915 dosimetric criteria in peripheral lung cancer patients treated with stereotactic body radiotherapy.

    Science.gov (United States)

    Pokhrel, Damodar; Sood, Sumit; Badkul, Rajeev; Jiang, Hongyu; McClinton, Christopher; Lominska, Christopher; Kumar, Parvesh; Wang, Fen

    2016-01-01

    The purpose of the study was to evaluate Monte Carlo-generated dose distributions with the X-ray Voxel Monte Carlo (XVMC) algorithm in the treatment of peripheral lung cancer patients using stereotactic body radiotherapy (SBRT) with non-protocol dose-volume normalization and to assess plan outcomes utilizing RTOG 0915 dosimetric compliance criteria. The Radiation Therapy Oncology Group (RTOG) protocols for non-small cell lung cancer (NSCLC) currently require radiation dose to be calculated using tissue density heterogeneity corrections. Dosimetric criteria of RTOG 0915 were established based on superposition/convolution or heterogeneities corrected pencil beam (PB-hete) algorithms for dose calculations. Clinically, more accurate Monte Carlo (MC)-based algorithms are now routinely used for lung stereotactic body radiotherapy (SBRT) dose calculations. Hence, it is important to determine whether MC calculations in the delivery of lung SBRT can achieve RTOG standards. In this report, we evaluate iPlan generated MC plans for peripheral lung cancer patients treated with SBRT using dose-volume histogram (DVH) normalization to determine if the RTOG 0915 compliance criteria can be met. This study evaluated 20 Stage I-II NSCLC patients with peripherally located lung tumors, who underwent MC-based SBRT with heterogeneity correction using X-ray Voxel Monte Carlo (XVMC) algorithm (Brainlab iPlan version 4.1.2). Total dose of 50 to 54 Gy in 3 to 5 fractions was delivered to the planning target vol-ume (PTV) with at least 95% of the PTV receiving 100% of the prescription dose (V100% ≥ 95%). The internal target volume (ITV) was delineated on maximum intensity projection (MIP) images of 4D CT scans. The PTV included the ITV plus 5 mm uniform margin applied to the ITV. The PTV ranged from 11.1 to 163.0 cc (mean = 46.1 ± 38.7 cc). Organs at risk (OARs) including ribs were delineated on mean intensity projection (MeanIP) images of 4D CT scans. Optimal clinical MC SBRT plans were

  15. Antiprotons in the Cosmic Rays

    Science.gov (United States)

    Nutter, Scott

    1999-10-01

    The HEAT (High Energy Antimatter Telescope) collaboration flew in May 1999 a balloon-borne instrument to measure the relative abundance of antiprotons and protons in the cosmic rays to kinetic energies of 30 GeV. The instrument uses a multiple energy loss technique to measure the Lorentz factor of through-going cosmic rays, a magnet spectrometer to measure momentum, and several scintillation counters to determine particle charge and direction (up or down in the atmosphere). The antiproton/proton abundance ratio as a function of energy is a probe of the propagation environment of protons through the galaxy. Existing measurements indicate a higher than expected value at both high and low energies. A confirming measurement could indicate peculiar antiproton sources, such as WIMPs or supersymmetric darkmatter candidates. A description of the instrument, details of the flight and instrument performance, and status of the data analysis will be given.

  16. Nuclear dynamics induced by antiprotons

    CERN Document Server

    Feng, Zhao-Qing

    2015-01-01

    Reaction dynamics in collisions of antiprotons on nuclei is investigated within the Lanzhou quantum molecular dynamics model. The reaction channels of elastic scattering, annihilation, charge exchange and inelastic collisions of antiprotons on nucleons have been included in the model. Dynamics on particle production, in particular pions, kaons, antikaons and hyperons, is investigated in collisions of $\\overline{p}$ on $^{12}$C, $^{20}$Ne, $^{40}$Ca and $^{181}$Ta from a low to high incident momenta. It is found that the annihilations of $\\overline{p}$ on nucleons are of importance on the dynamics of particle production in phase space. Hyperons are mainly produced via meson induced reactions on nucleons and strangeness exchange collisions, which lead to the delayed emission in antiproton-nucleus collisions.

  17. Measurement of interaction between antiprotons

    CERN Document Server

    ,

    2015-01-01

    One of the primary goals of nuclear physics is to understand the force between nucleons, which is a necessary step for understanding the structure of nuclei and how nuclei interact with each other. Rutherford discovered the atomic nucleus in 1911, and the large body of knowledge about the nuclear force since acquired was derived from studies made on nucleons or nuclei. Although antinuclei up to antihelium-4 have been discovered and their masses measured, we have no direct knowledge of the nuclear force between antinucleons. Here, we study antiproton pair correlations among data taken by the STAR experiment at the Relativistic Heavy Ion Collider and show that the force between two antiprotons is attractive. In addition, we report two key parameters that characterize the corresponding strong interaction: namely, the scattering length (f0) and effective range (d0). As direct information on the interaction between two antiprotons, one of the simplest systems of antinucleons, our result provides a fundamental ingr...

  18. Antiproton annihilation in quantum chromodynamics

    International Nuclear Information System (INIS)

    Anti-proton annihilation has a number of important advantages as a probe of QCD in the low energy domain. Exclusive reaction in which complete annihilation of the valance quarks occur. There are a number of exclusive and inclusive /bar p/ reactions in the intermediate momentum transfer domain which provide useful constraints on hadron wavefunctions or test novel features of QCD involving both perturbative and nonperturbative dynamics. Inclusive reactions involving antiprotons have the advantage that the parton distributions are well understood. In these lectures, I will particularly focus on lepton pair production /bar p/A → /ell//bar /ell//X as a means to understand specific nuclear features in QCD, including collision broadening, breakdown of the QCD ''target length condition''. Thus studies of low to moderate energy antiproton reactions with laboratory energies under 10 GeV could give further insights into the full structure of QCD. 112 refs., 40 figs

  19. Integrated peripheral boost in preoperative radiotherapy for the locally most advanced non-resectable rectal cancer patients

    International Nuclear Information System (INIS)

    Background and Purpose: Few studies have explored the potential clinical advantages of dose escalation and integrated boosts for patients with non-resectable locally advanced rectal cancer. The possibility of escalating dose to non-resectable regions in these patients was the aim of this study. Patients and methods: Seven patients with locally very advanced rectal tumours (sacrum overgrowth or growth into pelvic side walls) were evaluated. Intensity modulated photon and pencil beam scanning proton plans with simultaneously integrated boosts (45 Gy to elective lymph nodes, 50 Gy to tumour and 62.5 Gy to boost area in 25 fractions) were compared. Results: Target coverage was achieved with both photon and proton plans. Estimated risks of acute side effects put the two patients with the largest tumours at unacceptable risk for intestinal toxicity, regardless of modality. The remaining five patients had beneficial sparing of dose to the small intestine with protons. Conclusions: Adding boost to areas where rectal tumours infiltrate adjacent non-resectable organs is an attractive option which appears possible using both photon and proton irradiation. Proton plans reduced dose to organs at risk. Integrated peripheral boosts should be considered more frequently in these very advanced tumours

  20. LEAR (Low Energy Antiproton Ring), general view.

    CERN Multimedia

    1990-01-01

    When the Antiproton Project was launched in the late 1970s, it was recognized that in addition to the primary purpose of high-energy proton-antiproton collisions in the SPS, there was interesting physics to be done with low-energy antiprotons. In 1982, LEAR was ready to receive antiprotons from the Antiproton Accumulator (AA), via the PS. A year later, delivery of antiprotons to the experiments began, at momenta as low as 100 MeV/c (kinetic energy 5.3 MeV), in an "Ultra-Slow Extraction" mode, dispensing some E9 antiprotons over times counted in hours. For such an achievement, stochastic and electron cooling had to be brought to high levels of perfection.

  1. Some prospects for antiproton physics

    International Nuclear Information System (INIS)

    Some of the possibilities for fruitful research with antiprotons are outlined below. Special emphasis is placed on the possibility of learning about quark spectroscopy and dynamics using highly precise and intense anti p beams such as LEAR. It is urged that any discussion of LAMPF II give very careful consideration to the construction of a facility competitive with LEAR

  2. Biological Effectiveness of Antiproton Annihilation

    DEFF Research Database (Denmark)

    Maggiore, C.; Agazaryan, N.; Bassler, N.;

    2004-01-01

    A new experiment, AD-4/ACE (antiproton cell experiment), has been approved by the CERN Research Board. The experiment is scheduled to begin taking data in June and continue through the 2003 run cycle. The experiment is designed to determine whether or not the densely ionizing particles emanating...

  3. Physics at CERN's Antiproton Decelerator

    CERN Document Server

    Hori, M

    2013-01-01

    The Antiproton Decelerator of CERN began operation in 1999 to serve experiments for studies of CPT invariance by precision laser and microwave spectroscopy of antihydrogen ($\\bar{\\rm H}$) and antiprotonic helium ($\\bar{p}{\\rm He}^+$). The first 12 years of operation saw cold $\\bar{\\rm H}$ synthesized by overlapping clouds of positrons ($e^+$) and antiprotons ($\\bar{p}$) confined in magnetic Penning traps. Cold $\\bar{\\rm H}$ was also produced in collisions between Rydberg positronium atoms and $\\bar{p}$. Ground-state $\\bar{\\rm H}$ was later trapped for up to $\\sim 1000$ s in a magnetic bottle trap, and microwave transitions excited between its hyperfine levels. In the $\\bar{p}{\\rm He}^+$ atom, UV transitions were measured to a precision of (2.3-5) $\\times$ $10^{-9}$ by sub-Doppler two-photon laser spectroscopy. From this the antiproton-to-electron mass ratio was determined as $M_{\\bar{p}}/m_e=$1836.1526736(23), which agrees with the p value. Microwave spectroscopy of $\\bar{p}{\\rm He}^+$ yielded a measurement o...

  4. Antiproton Stacking in the Recycler

    CERN Document Server

    Burov, A

    2003-01-01

    Possibilities to accumulate antiprotons in the Recycler are considered for three different cases: with current stochastic cooling, with upgraded stochastic cooling and with electron cooling. With stochastic cooling only, even upgraded, Recycler looks hardly useful. However, with electron cooling at its goal parameters and reasonably good vacuum in the Recycler, this machine would be efficient.

  5. Proton-Antiproton Collider Physics

    OpenAIRE

    Shochet, Melvyn J.

    1995-01-01

    Comment: Summary of the 10th Topical Workshop on Proton-Antiproton Collider Physics, Fermilab, May 9-13, 1995. Postscript file (34 pages with 82 embedded figures; 5.7 MB) available at http://www-cdf.fnal.gov/physics/conf95/cdf3225_pbarp_wkshp_summary.ps

  6. Measurement of interaction between antiprotons

    Czech Academy of Sciences Publication Activity Database

    Adamczyk, L.; Bielčík, J.; Bielčíková, Jana; Federič, Pavol; Chaloupka, P.; Rusňák, Jan; Rusňáková, O.; Šimko, Miroslav; Šumbera, Michal; Tlustý, David; Trzeciak, B. A.; Vértési, Robert

    2015-01-01

    Roč. 527, č. 7578 (2015), s. 345-348. ISSN 0028-0836 R&D Projects: GA ČR GA13-20841S Institutional support: RVO:61389005 Keywords : STAR collaboration * antiprotons * protons Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 41.456, year: 2014

  7. Example of an Antiproton-Nucleon Annihilation

    Energy Technology Data Exchange (ETDEWEB)

    Chamberlain, O.; Chupp, W.W.; Ekspong, A.G.; Goldhaber, G.; Goldhaber, S.; Lofgren, E.J.; Segre, E.; Wiegand, C.; Amaldi, E.; Baroni,G.; Castagnoli, C.; Franzinetti, C.; Manfredini, A.

    1956-02-27

    The existence of antiprotons has recently been demonstrated at the Berkeley Bevatron by a counter experiment. The antiprotons were found among the momentum-analyzed (1190 Mev/c) negative particles emitted by a copper target bombarded by 6.2-Bev protons. Concurrently with the counter experiment, stacks of nuclear emulsions were exposed in the beam adjusted to 1090 Mev/c negative particles in an experiment designed to observe the properties of antiprotons when coming to rest. This required a 132 g/cm2 copper absorber to slow down the antiprotons sufficiently to stop them in the emulsion stack. Only one antiproton was found in stacks in which seven were expected, assuming a geometric interaction cross section for antiprotons in copper. It has now been found that the cross section in copper is about twice geometric, which explains this low yield.

  8. Antiproton source beam position system

    International Nuclear Information System (INIS)

    The TeV I Beam Position Monitor (BPM) system is designed to provide a useful diagnostic tool during the commissioning and operational phases of the antiproton source. Simply stated the design goal is to provide single turn position information for intensities of > 1x109 particles, and multi-turn (clocked orbit) information for beam intensities of > 1x107 particles, both with sub-millimeter resolution. It is anticipated that the system will be used during commissioning for establishing the first turn through the Debuncher and Accumulator, for aligning injection orbits, for providing information necessary to correct closed orbits, and for measuring various machine parameters (e.g. tunes, dispersion, aperture, chromaticity). During normal antiproton operation the system will be used to monitor the beam position throughout the accumulation process

  9. Radiation studies in the antiproton source

    International Nuclear Information System (INIS)

    Experiment E760 has a lead glass (Pb-G) calorimeter situated in the antiproton source tunnel in the accumulator ring at location A50. This location is exposed to radiation from several sources during antiproton stacking operations. A series of radiation studies has been performed over the last two years to determine the sources of this radiation and as a result, some shielding has been installed in the antiproton source in order to protect the lead glass from radiation damage

  10. Interaction of antiproton with nuclei

    Czech Academy of Sciences Publication Activity Database

    Hrtánková, Jaroslava; Mareš, Jiří

    Vol. 234. Dordrecht: Springer, 2015, s. 93-98. ISSN 0304-3843. [5th International Conference on Exotic Atoms and Related Topics (EXA). Vienna (AT), 15.09.2014-19.09.2014] R&D Projects: GA ČR(CZ) GAP203/12/2126 Institutional support: RVO:61389005 Keywords : antiproton-nucleus interaction * RMF model * G-parity Subject RIV: BE - Theoretical Physics

  11. Search for Polarization Effects in the Antiproton Production Process

    International Nuclear Information System (INIS)

    For the production of a polarized antiproton beam, various methods have been suggested including the possibility that antiprotons may be produced polarized which will be checked experimentally. The polarization of antiprotons produced under typical conditions for antiproton beam preparation will be measured at the CERN/PS. If the production process creates some polarization, a polarized antiproton beam could be prepared by a rather simple modification of the antiproton beam facility. The detection setup and the expected experimental conditions are described

  12. Physics with Antiprotons at PANDA

    International Nuclear Information System (INIS)

    The PANDA experiment is part of the core project of the planned Facility for Antiproton and Ion Research (FAIR) at GSI in Darmstadt (Germany)[1]. One major component of the upgraded accelerator complex is the High Energy Storage Ring (HESR) which will provide a high quality antiproton beam in the momentum range between 1.5 and 15 GeV/c. PANDA, a fixed target experiment directly implemented in the HESR, will investigate antiproton annihilations with the aim to explore fundamental questions in the cross over region of the non perturbative and the strong QCD. Due to the planned extensive physics program a multipurpose detector with a nearly complete solid angle coverage, proper particle identification over a large momentum range, and high resolution calorimetry for neutral particles is required. After an overview about the goals and the detector design of the PANDA experiment major parts of the planned physics program will be discussed, namely the meson spectroscopy and the search for exotics in the charmonium and open charm region

  13. Ultra-low Energy Antiprotons at FLAIR

    OpenAIRE

    Welsch, C.; Grieser, M.; von Hahn, R; Orlov, D.; Wolf, A.; Ullrich, J.

    2004-01-01

    The Future Accelerator Facility for Beams of Ions and Antiprotons at Darmstadt will produce the highest flux of antiprotons in the world. So far it is foreseen to accelerate the antiprotons to high energies (3-15 GeV) for meson spectroscopy and other nuclear and particle physics experiments in the HESR (High Energy Storage Ring). Within the planned complex of storage rings, it is possible to decelerate the antiprotons to about 30 MeV kinetic energy, opening up the possibility to create low en...

  14. Peripheral dose measurements with diode and thermoluminescence dosimeters for intensity modulated radiotherapy delivered with conventional and un-conventional linear accelerator

    Directory of Open Access Journals (Sweden)

    Rajesh Kinhikar

    2013-01-01

    Full Text Available The objective of this paper was to measure the peripheral dose (PD with diode and thermoluminescence dosimeter (TLD for intensity modulated radiotherapy (IMRT with linear accelerator (conventional LINAC, and tomotherapy (novel LINAC. Ten patients each were selected from Trilogy dual-energy and from Hi-Art II tomotherapy. Two diodes were kept at 20 and 25 cm from treatment field edge. TLDs (LiF:MgTi were also kept at same distance. TLDs were also kept at 5, 10, and 15 cm from field edge. The TLDs were read with REXON reader. The readings at the respective distance were recorded for both diode and TLD. The PD was estimated by taking the ratio of measured dose at the particular distance to the prescription dose. PD was then compared with diode and TLD for LINAC and tomotherapy. Mean PD for LINAC with TLD and diode was 2.52 cGy (SD 0.69, 2.07 cGy (SD 0.88 at 20 cm, respectively, while at 25 cm, it was 1.94 cGy (SD 0.58 and 1.5 cGy (SD 0.75, respectively. Mean PD for tomotherapy with TLD and diode was 1.681 cGy SD 0.53 and 1.58 (SD 0.44 at 20 cm, respectively. The PD was 1.24 cGy (SD 0.42 and 1.088 cGy (SD 0.35 at 25 cm, respectively, for tomotherapy. Overall, PD from tomotherapy was found lower than LINAC by the factor of 1.2-1.5. PD measurement is essential to find out the potential of secondary cancer. PD for both (conventional LINAC and novel LINACs (tomotherapy were measured and compared with each other. The comparison of the values for PD presented in this work and those published in the literature is difficult because of the different experimental conditions. The diode and TLD readings were reproducible and both the detector readings were comparable.

  15. Design study of an Antiproton Collector for the Antiproton Accumulator (ACOL)

    International Nuclear Information System (INIS)

    The Report gives a full description of an Antiproton Collector Ring which, placed around the existing Antiproton Accumulator at CERN, would enhance the antiproton flux available to both the SPS and LEAR by a factor of ten. The new ring and the focusing devices which precede it are designed to accept a much larger fraction of the antiproton production cone from the target. Each pulse of particles will be pre-cooled before being fed to the Antiproton Accumulator, where improved stochastic cooling systems will build up the stack. A full list of parameters is included. (orig.)

  16. The Fermilab proton-antiproton collider upgrades

    International Nuclear Information System (INIS)

    The plans for increases in the Tevatron proton-antiproton collider luminosity in the near future (Run II) and the more distant future (TeV33) are described. While there are many important issues, the fundamental requirement is to produce more antiprotons and to use them more efficiently

  17. Antiproton radiation found effective in cancer research

    CERN Multimedia

    2003-01-01

    "An international collaboration of scientists has completed the first ever antiproton beam experiments designed to reveal the biological effectiveness of antiproton radiation in terminating cells used for cancer research...PBar Labs assembled the collaboration at CERN (European Organization for Nuclear Research in Geneva) to perform the measurements" (1 page).

  18. Physics with antiprotons at LEAR

    International Nuclear Information System (INIS)

    The low energy antiproton ring LEAR started to work at CERN in 1983. It provides clean anti p beams of much higher intensity and much better quality than available so far in the range from 0.1 to 2 GeV/c momentum. 16 of the 17 accepted experiments are installed and 14 of them took first data in 1983. After approx.= 240 hours of LEAR operation very first results are available. One can expect that exciting physics results be produced in many different domains provided LEAR gets enough anti p in the future. (orig.)

  19. Proceedings of the 10 May 1989 Antiproton Technology Workshop: Addendum

    Science.gov (United States)

    Nordley, Gerald D.

    1989-09-01

    Antiprotons are particles of antimatter which release highly penetrating radiation when they are stopped in normal matter. According to presentations at the Antiproton Technology Workshop this radiation can be used, in very small quantities, to image objects and determine their composition and density. In larger amounts, the radiation could be used to kill cancer tumors or produce highly localized heating and shock waves. Titles of presentations include: Stopping Power of MeV Proton and Antiproton Beams; Recent Simulation Results of ASTER; Pbar Testing of Hydrogen Effects in Sealed Carbon-Carbon Composites; Potential for Antiprotons in Radiation Oncology; Prospects for a Commercial Antiproton Source; Prospects for Exciting Extreme States in Nuclear Matter with Intense Antiproton Beams; Status of AL Studies Relating to condensed Antimatter; Electromagnetic Traps for Atomic Antihydrogen; Antihydrogen Production; Antiproton Catalyzed Fusion; Antiproton Induced Fusion Reaction; Modeling Antiproton-Plasma Interactions; Introduction to CP Violation Studies with Pbars; and Antiproton Production Calculation by the Multistring Model VENUS.

  20. Antiproton fast ignition for inertial confinement fusion

    International Nuclear Information System (INIS)

    With 180 MJ/microg, antiprotons offer the highest stored energy per unit mass of any known entity. The use of antiprotons to promote fast ignition in an inertial confinement fusion (ICF) capsule and produce high target gains with only modest compression of the main fuel is investigated. Unlike standard fast ignition where the ignition energy is supplied by energetic, short pulse laser, the energy here is supplied through the ionization energy deposited when antiprotons annihilate at the center of a compressed fuel capsule. This can be considered in-situ fast ignition as it obviates the need for the external injection of the ignition energy. In the first of two candidate schemes, the antiproton package is delivered by a low-energy ion beam. In the second, autocatalytic scheme, the antiprotons are preemplaced at the center of the capsule prior to compression. In both schemes, the author estimates that ∼1012 antiprotons are required to initiate fast ignition in a typical ICF capsule and show that incorporation of a thin, heavy metal shell is desirable to enhance energy deposition within the ignitor zone. In addition to eliminating the need for a second, energetic fast laser and vulnerable final optics, this scheme would achieve central ignition without reliance on laser channeling through halo plasma or Hohlraum debris. However, in addition to the practical difficulties of storage and manipulation of antiprotons at low energy, the other large uncertainty for the practicality of such a speculative scheme is the ultimate efficiency of antiproton production in an external, optimized facility. Estimates suggest that the electrical wall plug energy per pulse required for the separate production of the antiprotons is of the same order as that required for the conventional slow compression driver

  1. The anti-proton charge radius

    CERN Document Server

    Crivelli, P; Heiss, M W

    2016-01-01

    The upcoming operation of the Extra Low ENergy Antiprotons (ELENA) ring at CERN, the upgrade of the anti-proton decelerator (AD), and the installation in the AD hall of an intense slow positron beam with an expected flux of $10^{8}$ e$^+$/s will open the possibility for new experiments with anti-hydrogen ($\\bar{\\text{H}}$). Here we propose a scheme to measure the Lamb shift of $\\bar{\\text{H}}$. For a month of data taking, we anticipate an uncertainty of 100 ppm. This will provide a test of CPT and the first determination of the anti-proton charge radius at the level of 10%.

  2. Gold fragmentation induced by stopped antiprotons

    OpenAIRE

    Lubinski, P.; Grochulska, A.; von Egidy, T.; Gulda, K.; Hartmann, F. J.; Jastrzebski, J.; Kurcewicz, W.; Pienkowski, L.; Stolarz, A.; Trzcinska, A.

    2002-01-01

    A natural gold target was irradiated with the antiproton beam from the Low Energy Antiproton Ring at CERN. Antiprotons of 200 MeV/c momentum were stopped in a thick target, products of their annihilations on Au nuclei were detected using the off-line gamma-ray spectroscopy method. In total, yields for 114 residual nuclei were determined, providing a data set to deduce the complete mass and charge distribution of all products with A > 20 from a fitting procedure. The contribution of evaporatio...

  3. Information on antiprotonic atoms and the nuclear periphery from the PS209 experiment

    OpenAIRE

    Trzcinska, A.; Jastrzebski, J.; Czosnyka, T.; von Egidy, T.; Gulda, K.; Hartmann, F. J.; Iwanicki, J.; Ketzer, B.; Kisielinski, M.; Klos, B.; Kurcewicz, W.; Lubinski, P.; Napiorkowski, P. J.; Pienkowski, L.; Schmidt, R.

    2001-01-01

    In the PS209 experiments at CERN two kinds of measurements were performed: the in-beam measurement of X-rays from antiprotonic atoms and the radiochemical, off-line determination of the yield of annihilation products with mass number A_t -1 (less by 1 than the target mass). Both methods give observables which allows to study the peripheral matter density composition and distribution.

  4. Prospects for Antiproton Experiments at Fermilab

    CERN Document Server

    Kaplan, Daniel M

    2011-01-01

    Fermilab operates the world's most intense antiproton source. Newly proposed experiments can use those antiprotons either parasitically during Tevatron Collider running or after the end of the Tevatron Collider program. For example, the annihilation of 5 to 8 GeV antiprotons is expected to yield world-leading sensitivities to hyperon rare decays and CP violation. It could also provide the world's most intense source of tagged D^0 mesons, and thus the best near-term opportunity to study charm mixing and, via CP violation, to search for new physics. Other measurements that could be made include properties of the X(3872) and the charmonium system. An experiment using a Penning trap and an atom interferometer could make the world's most precise measurement of the gravitational force on antimatter. These and other potential measurements using antiprotons offer a great opportunity for a broad and exciting physics program at Fermilab in the post-Tevatron era.

  5. Antiproton Induced Fission and Fragmentation of Nuclei

    CERN Multimedia

    2002-01-01

    The annihilation of slow antiprotons with nuclei results in a large highly localized energy deposition primarily on the nuclear surface. \\\\ \\\\ The study of antiproton induced fission and fragmentation processes is expected to yield new information on special nuclear matter states, unexplored fission modes, multifragmentation of nuclei, and intranuclear cascades.\\\\ \\\\ In order to investigate the antiproton-nucleus interaction and the processes following the antiproton annihilation at the nucleus, we propose the following experiments: \\item A)~Measurement of several fragments from fission and from multifragmentation in coincidence with particle spectra, especially neutrons and kaons. \\item B)~Precise spectra of $\\pi$, K, n, p, d and t with time-of-flight techniques. \\item C)~Installation of the Berlin 4$\\pi$ neutron detector with a 4$\\pi$ Si detector placed inside for fragments and charged particles. This yields neutron multiplicity distributions and consequently distributions of thermal excitation energies and...

  6. Physics with ultra-low energy antiprotons

    International Nuclear Information System (INIS)

    The experimental observation that all forms of matter experience the same gravitational acceleration is embodied in the weak equivalence principle of gravitational physics. However no experiment has tested this principle for particles of antimatter such as the antiproton or the antihydrogen atom. Clearly the question of whether antimatter is in compliance with weak equivalence is a fundamental experimental issue, which can best be addressed at an ultra-low energy antiproton facility. This paper addresses the issue. 20 refs

  7. Low Energy Antiproton Experiments -- A Review

    OpenAIRE

    Jungmann, Klaus P.

    2005-01-01

    Low energy antiprotons offer excellent opportunities to study properties of fundamental forces and symmetries in nature. Experiments with them can contribute substantially to deepen our fundamental knowledge in atomic, nuclear and particle physics. Searches for new interactions can be carried out by studying discrete symmetries. Known interactions can be tested precisely and fundamental constants can be extracted from accurate measurements on free antiprotons ($\\bar{p}$'s) and bound two- and ...

  8. Peripheral neuropathy

    Science.gov (United States)

    Peripheral neuritis; Neuropathy - peripheral; Neuritis - peripheral; Nerve disease; Polyneuropathy ... Katirji B, Koontz D. Disorders of peripheral nerves. In: Daroff RB, ... Practice . 6th ed. Philadelphia, PA: Elsevier Saunders; 2012: ...

  9. Neutron fluence in antiproton radiotherapy, measurements and simulations

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael H.; Petersen, Jørgen B.B.

    2010-01-01

    part of the fast neutron spectrum using Lithium-6 and -7 Fluoride TLD pairs. The experimental results are found to be in good agreement with simulations using the Monte Carlo particle transport code FLUKA. The thermal neutron kerma resulting from the measured thermal neutron fluence is insignificant...... compared to the contribution from fast neutrons. The results are found to be similar to values calculated for pion treatment, however exact modeling under more realistic treatment scenarios is still required to quantitatively compare these treatment modalities....

  10. The antiproton depth–dose curve in water

    CERN Document Server

    Bassler, N; Jäkel, O; Knudsen, H V; Kovacevic, S

    2008-01-01

    We have measured the depth–dose curve of 126 MeV antiprotons in a water phantom using ionization chambers. Since the antiproton beam provided by CERN has a pulsed structure and possibly carries a high-LET component from the antiproton annihilation, it is necessary to correct the acquired charge for ion recombination effects. The results are compared with Monte Carlo calculations and were found to be in good agreement. Based on this agreement we calculate the antiproton depth–dose curve for antiprotons and compare it with that for protons and find a doubling of the physical dose in the peak region for antiprotons.

  11. Polarized antiproton beam at U-70 accelerator of IHEP

    Science.gov (United States)

    Nurushev, S. B.; Chetvertkov, M. A.; Chetvertkova, V. A.; Garkusha, V. I.; Meschanin, A. P.; Mochalov, V. V.; Nurusheva, M. B.; Rykov, V. L.; Semenov, P. A.; Strikhanov, M. N.; Vasiliev, A. N.; Zapolsky, V. N.

    2016-02-01

    The polarized proton and antiproton beam channel is currently under development at the U-70 accelerator of IHEP, Protvino, Russia. An availability of the both, polarized protons and antiprotons provides an exciting opportunity for the comparative studies of spin effects induced by polarized protons and antiprotons in a variety of hadronic reactions. While the proton and antiproton beams are formed by essentially the same method, there is the specific in the antiproton beam shaping and properties compared to protons. In this report, we address some technical details of forming the polarized antiproton beam and describe its main properties.

  12. Antiproton-nucleus potentials from global fits to antiprotonic X-rays and radiochemical data

    Czech Academy of Sciences Publication Activity Database

    Friedman, E.; Gal, A.; Mareš, Jiří

    2005-01-01

    Roč. 761, 3/4 (2005), s. 283-295. ISSN 0375-9474 R&D Projects: GA AV ČR IAA1048305 Institutional research plan: CEZ:AV0Z10480505 Keywords : antiproton-nuclear interaction * RMF calculations * antiproton X-rays Subject RIV: BE - Theoretical Physics Impact factor: 1.950, year: 2005

  13. Antiproton annihilation physics in the Monte Carlo particle transport code SHIELD-HIT12A

    International Nuclear Information System (INIS)

    The Monte Carlo particle transport code SHIELD-HIT12A is designed to simulate therapeutic beams for cancer radiotherapy with fast ions. SHIELD-HIT12A allows creation of antiproton beam kernels for the treatment planning system TRiP98, but first it must be benchmarked against experimental data. An experimental depth dose curve obtained by the AD-4/ACE collaboration was compared with an earlier version of SHIELD-HIT, but since then inelastic annihilation cross sections for antiprotons have been updated and a more detailed geometric model of the AD-4/ACE experiment was applied. Furthermore, the Fermi–Teller Z-law, which is implemented by default in SHIELD-HIT12A has been shown not to be a good approximation for the capture probability of negative projectiles by nuclei. We investigate other theories which have been developed, and give a better agreement with experimental findings. The consequence of these updates is tested by comparing simulated data with the antiproton depth dose curve in water. It is found that the implementation of these new capture probabilities results in an overestimation of the depth dose curve in the Bragg peak. This can be mitigated by scaling the antiproton collision cross sections, which restores the agreement, but some small deviations still remain. Best agreement is achieved by using the most recent antiproton collision cross sections and the Fermi–Teller Z-law, even if experimental data conclude that the Z-law is inadequately describing annihilation on compounds. We conclude that more experimental cross section data are needed in the lower energy range in order to resolve this contradiction, ideally combined with more rigorous models for annihilation on compounds

  14. Antiprotons four times more effective than protons for cell irradiation

    CERN Multimedia

    2006-01-01

    "A pioneering experiment at CERN with potential future application in cancer therapy has produced its first results. Started in 2003, ACE (Antiproton Cell Experiment) is the first investigation of the biological effects of antiprotons." (1,5 page)

  15. Antiprotons four times more effective than protons for cell irradiation

    CERN Multimedia

    2007-01-01

    "A pioneering experiment at CERN with potential future application in cancer therapy has produced its first results. Started in 2003, ACE (Antiproton Cell Experiment) is the first investigation of the biological effects of antiprotons." (1,5 page)

  16. Ultralow-energy antiprotons for antihydrogen spectroscopy and antimatter gravity

    International Nuclear Information System (INIS)

    Approximately one million antiprotons have been captured in a large-scale Penning trap at the Low Energy Antiproton Ring (LEAR) at CERN. Up to 65% of the captured antiprotons have subsequently been electron cooled to energies below 1 eV and have been stored up to one hour. This has opened new discussions of the possible use of ultralow-energy antiprotons for gravitational physics, as well as for precision spectroscopy of antihydrogen for CPT tests

  17. The Antiproton Depth-Dose Curve in Water

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael; Jäkel, Oliver; Knudsen, Helge; Kovacevic, Sandra; AD-4/ACE Collaboration

    2008-01-01

    We have measured the depth-dose curve of 126 MeV antiprotons in a water phantom using ionization chambers. Since the antiproton beam provided by CERN has a pulsed structure and possibly carries a high-LET component from the antiproton annihilation, it is necessary to correct the acquired charge for...

  18. Antiproton beam polarizer using a dense polarized target

    Energy Technology Data Exchange (ETDEWEB)

    Wojtsekhowski, Bogdan

    2011-05-01

    We describe considerations regarding the spin filtering method for the antiproton beam. The proposed investigation of the double polarization cross section for antiproton to nucleon interaction is outlined. It will use a single path of the antiproton beam through a dense polarized target, e.g. 3He or CH2, followed by a polarimeter.

  19. The HEAT Cosmic Ray Antiproton Experiment

    Science.gov (United States)

    Nutter, Scott

    1998-10-01

    The HEAT (High Energy Antimatter Telescope) collaboration is constructing a balloon-borne instrument to measure the relative abundance of antiprotons and protons in the cosmic rays to kinetic energies of 30 GeV. The instrument uses a multiple energy loss technique to measure the Lorentz factor of through-going cosmic rays, a magnet spectrometer to measure momentum, and several scintillation counters to determine particle charge and direction (up or down in the atmosphere). The antiproton to proton abundance ratio as a function of energy is a probe of the propagation environment of protons through the galaxy. Existing measurements indicate a higher than expected value at both high and low energies. A confirming measurement could indicate peculiar antiproton sources, such as WIMPs or supersymmetric darkmatter candidates.

  20. Cosmic ray antiprotons from nearby cosmic accelerators

    Science.gov (United States)

    Joshi, Jagdish C.; Gupta, Nayantara

    2015-05-01

    The antiproton flux measured by PAMELA experiment might have originated from Galactic sources of cosmic rays. These antiprotons are expected to be produced in the interactions of cosmic ray protons and nuclei with cold protons. Gamma rays are also produced in similar interactions inside some of the cosmic accelerators. We consider a few nearby supernova remnants observed by Fermi LAT. Many of them are associated with molecular clouds. Gamma rays have been detected from these sources which most likely originate in decay of neutral pions produced in hadronic interactions. The observed gamma ray fluxes from these SNRs are used to find out their contributions to the observed diffuse cosmic ray antiproton flux near the earth.

  1. Low energy antiproton possibilities at the AGS

    International Nuclear Information System (INIS)

    The technical feasibility of creating a pure antiproton beam at the AGS has been studied. The scheme involves an antiproton target station and transport back to the Booster synchrotron, which acts as both a purifier and accelerator/decelerator. This proposal would be very attractive to the user community since this operation could run parasitically (transparently) to the AGS operating modes. The energy range of antiprotons can be as low as 2 MeV to as high as 5 GeV. The intensity of the beam is estimated to be 7 x 107/sec above 2.5 GeV/c and 4 x 104/sec at 200 MeV/c

  2. K-shell ionization by antiprotons

    International Nuclear Information System (INIS)

    We present first calculations for the impact parameter dependence of K-shell ionization rates in anti pCu and in anti pAg collisions at various projectile energies. We show that the effect of the attractive Coulomb potential on the Rutherford trajectory and the anti-binding effect caused by the negative charge of the antiproton result in a considerable increase of the ionization probability. Total ionization cross-sections for proton and antiproton projectiles are compared with each other and with experimental ionization cross-sections for protons. (orig.)

  3. The ASACUSA experiment at CERN's AD antiproton decelerator catches antiprotons in helium, where the antiprotons replace electrons, giving exotics atoms.

    CERN Multimedia

    Loïez, P

    2000-01-01

    Photo 03: Laser beams are prepared for shooting at antiprotonic helium atoms. Left to right: Masaki Hori (Tokyo University) and John Eades (CERN). Photo 01: Dye laser triggered by "YAG" laser. Photo 02: Masaki Hori adjusting optical system of laser beams.

  4. Antiproton-proton resonant like channels in J/Psi decays into photon, proton and antiproton

    CERN Document Server

    Loiseau, B

    2005-01-01

    The BES collaboration has recently observed a strong enhancement close to the proton-antiproton threshold in the J/Psi decays into photon, proton and antiproton. Such a structure can be explained by a traditional nucleon-antinucleon model. The near threshold 1S0 bound state and/or the well-established 3P0 resonant state found in this nucleon-antinucleon interaction can adequately describe the BES data.

  5. Protective effects of adrenochrome monoaminoguanidine methanesulfonate (AMM) and cytochrome C (CCC) on natural killer cells in the peripheral blood of cancer patients during radiotherapy

    International Nuclear Information System (INIS)

    The purpose of this study was to examine radioprotective effects of adrenochrome monoaminoguanidine methanesulfonate (AMM) and cytochrome C (CCC) on lymphocyte subset during radiotherapy (RT). Sixty five patients received irradiation of 50 Gy or more to the chest field of 100 cm2 or larger. The patients were classified into four groups: those treated with RT alone (Group I, n=15), combined RT and OK-432 (Group II, n=15), combined RT and AMMM + CCC (Group III, n=17), and combined RT and AMM + CCC + OK-432 (Group IV, n=18). Lymphocytes decreased by 64% after RT in Group I and by 50% in Group III. AMM and CCC prevented a decrease in the absolute number of potent natural killer cells and activated T cells, with statistically significant differences. In Group III, the absolute number of activated T cells tended to increase even after RT. Cytotoxic T cells decreased by only 11% after RT in Group III, as compared with 58% in Group I. As found in Groups II and IV, the combination of OK-432 did not have so protective effects on lymphocytes associated with RT as AMM + CCC combined with RT in Groups III. In view of the selective protection for potent natural killer cells and activated T cells, AMM + CCC seemed to serve as biological response modifiers, as well as radioprotective agents. (N.K.)

  6. Three dimensional biological dose distribution of antiprotons

    International Nuclear Information System (INIS)

    The goal of external beam cancer therapy is to destroy the tumour while sparing the healthy tissue around it. In hadron therapy, the dose profile of heavy charged particles satisfies this request, because most of the energy is deposited at the end of the particle path, in the Bragg peak. Antiprotons are even more promising, thanks to the extra energy released by annihilation when captured in a normal atom at the end of range. The aim of the AD-4/ACE experiment at CERN is to determine the increase in biological dose near the Bragg peak due to densely ionizing particles emanating from the annihilation of antiprotons. Initial experiments showed the damage to cells inflicted at the end of the beam for identical damage at the skin level to be four times higher for antiprotons than for protons. The radiation field in a spread-out Bragg peak produced with antiprotons is highly mixed and for proper dose planning knowledge of linear energy transfer (LET) and relative biological efficiency (RBE) at any point in the target is needed. We are studying a number of detection methods for their response to mixed radiation fields with the goal to obtain a direct measurement of the 3D LET distribution and report on first results.

  7. A naturally occurring trap for antiprotons

    International Nuclear Information System (INIS)

    The phenomenon of delayed annihilation of antiprotons in helium is the first instance of a naturally occurring trap for antimatter in ordinary matter. Recent studies of this effect at CERN are summarized, and plans are described for laser excitation experiments to test its interpretation in terms of metastable exotic helium atom formation. (author)

  8. Ionization in antiproton-hydrogen collisions

    International Nuclear Information System (INIS)

    Employing the semiclassical approximation we calculate within the coupled-state formalism the ionization probability in antiproton-hydrogen (anti p+H) collisions. In particular we investigate the adiabatic ionization at the distance of closest approach in almost central collisions. Striking differences in the electron excitation probability compared with proton-hydrogen (p+H) collisions are predicted. (orig.)

  9. Conceptual Design of an Antiproton Generation and Storage Facility

    International Nuclear Information System (INIS)

    The Antiproton Generation and Storage Facility (AGSF) creates copious quantities of antiprotons, for bottling and transportation to remote cancer therapy centers. The first step in the generation and storage process is to accelerate an intense proton beam down the Main Linac for injection into the Main Ring, which is a Rapid Cycling Synchrotron that accelerates the protons to high energy. The beam is then extracted from the ring into a transfer line and into a Proton Target. Immediately downstream of the target is an Antiproton Collector that captures some of the antiprotons and focuses them into a beam that is transported sequentially into two antiproton rings. The Precooler ring rapidly manipulates antiproton bunches from short and broad (in momentum) to long and thin. It then performs some preliminary beam cooling, in the fraction of a second before the next proton bunch is extracted from the Main Ring. Pre-cooled antiprotons are passed on to the Accumulator ring before the next antiprotons arrive from the target. The Accumulator ring cools the antiprotons, compressing them into a dense state that is convenient for mass storage over many hours. Occasionally the Accumulator ring decelerates a large number of antiprotons, injecting them into a Deceleration Linac that passes them into a waiting Penning trap

  10. Conceptual Design of an Antiproton Generation and Storage Facility

    Energy Technology Data Exchange (ETDEWEB)

    Peggs, Stephen

    2006-10-24

    The Antiproton Generation and Storage Facility (AGSF) creates copious quantities of antiprotons, for bottling and transportation to remote cancer therapy centers. The first step in the generation and storage process is to accelerate an intense proton beam down the Main Linac for injection into the Main Ring, which is a Rapid Cycling Synchrotron that accelerates the protons to high energy. The beam is then extracted from the ring into a transfer line and into a Proton Target. Immediately downstream of the target is an Antiproton Collector that captures some of the antiprotons and focuses them into a beam that is transported sequentially into two antiproton rings. The Precooler ring rapidly manipulates antiproton bunches from short and broad (in momentum) to long and thin. It then performs some preliminary beam cooling, in the fraction of a second before the next proton bunch is extracted from the Main Ring. Pre-cooled antiprotons are passed on to the Accumulator ring before the next antiprotons arrive from the target. The Accumulator ring cools the antiprotons, compressing them into a dense state that is convenient for mass storage over many hours. Occasionally the Accumulator ring decelerates a large number of antiprotons, injecting them into a Deceleration Linac that passes them into a waiting Penning trap.

  11. The discovery of geomagnetically trapped cosmic ray antiprotons

    CERN Document Server

    Adriani, O; Bazilevskaya, G A; Bellotti, R; Boezio, M; Bogomolov, E A; Bongi, M; Bonvicini, V; Borisov, S; Bottai, S; Bruno, A; Cafagna, F; Campana, D; Carbone, R; Carlson, P; Casolino, M; Castellini, G; Consiglio, L; De Pascale, M P; De Santis, C; De Simone, N; Di Felice, V; Galper, A M; Gillard, W; Grishantseva, L; Jerse, G; Karelin, A V; Kheymits, M D; Koldashov, S V; Krutkov, S Y; Kvashnin, A N; Leonov, A; Malakhov, V; Marcelli, L; Mayorov, A G; Menn, W; Mikhailov, V V; Mocchiutti, E; Monaco, A; Mori, N; Nikonov, N; Osteria, G; Palma, F; Papini, P; Pearce, M; Picozza, P; Pizzolotto, C; Ricci, M; Ricciarini, S B; Rossetto, L; Sarkar, R; Simon, M; Sparvoli, R; Spillantini, P; Stozhkov, Y I; Vacchi, A; Vannuccini, E; Vasilyev, G; Voronov, S A; Yurkin, Y T; Wu, J; Zampa, G; Zampa, N; Zverev, V G; 10.1088/2041-8205/736/1/L1

    2011-01-01

    The existence of a significant flux of antiprotons confined to Earth's magnetosphere has been considered in several theoretical works. These antiparticles are produced in nuclear interactions of energetic cosmic rays with the terrestrial atmosphere and accumulate in the geomagnetic field at altitudes of several hundred kilometers. A contribution from the decay of albedo antineutrons has been hypothesized in analogy to proton production by neutron decay, which constitutes the main source of trapped protons at energies above some tens of MeV. This Letter reports the discovery of an antiproton radiation belt around the Earth. The trapped antiproton energy spectrum in the South Atlantic Anomaly (SAA) region has been measured by the PAMELA experiment for the kinetic energy range 60--750 MeV. A measurement of the atmospheric sub-cutoff antiproton spectrum outside the radiation belts is also reported. PAMELA data show that the magnetospheric antiproton flux in the SAA exceeds the cosmic-ray antiproton flux by three ...

  12. X-ray transitions from antiprotonic noble gases

    International Nuclear Information System (INIS)

    The onset of antiprotonic X-ray transitions at high principal quantum numbers and the occurrence of electronic X-ray in antiprotonic argon krypton, and xenon is analysed with Multiconfiguration Dirac-Fock calculations. The shell by shell ionisation by Auger electron emission, characterised by appearance and disappearance of X-ray lines, is followed through the antiprotonic cascade by considering transition and binding energies of both the antiproton and remaining electrons. A number of additional lines in the X-ray spectra have been tentatively assigned to electronic transitions caused by electronic de-excitation after Auger emission during the antiprotonic cascade. A few lines remain unexplained so far or are not unambiguously assigned. The complexity of the electronic states cannot be resolved with semiconductor detectors. Hopefully, in future high resolution devices like crystal spectrometers and Auger electron spectroscopy at antiproton at GSI will resolve this complexity

  13. CERN accelerator school: Antiprotons for colliding beam facilities

    International Nuclear Information System (INIS)

    This is a specialized course which addresses a wide spectrum of theoretical and technological problems confronting the designer of an antiproton facility for high-energy-physics research. A broad and profound basis is provided by the lecturers' substantial experience gained over many years with CERN's unique equipment. Topics include beam optics, special lattices for antiproton accumulation and storage rings, antiproton production, stochastic cooling, acceleration and storage, r.f. noise, r.f. beam manipulations, beam-beam interaction, beam stability due to ion accumulation, and diagnostics. The SPS (Super Proton Synchrotron) panti p collider, LEAR (the Low Energy Antiproton Ring at CERN), antiprotons in the ISR (Intersecting Storage Rings), the new antiproton collector (ACOL) and gas jet targets are also discussed. A table is included listing the parameters of all CERN's accelerators and storage rings. See hints under the relevant topics. (orig./HSI)

  14. The cosmic ray antiproton background for AMS-02

    International Nuclear Information System (INIS)

    The AMS-02 experiment is measuring the cosmic ray antiproton flux with high precision. The interpretation of the upcoming data requires a thorough understanding of the secondary antiproton background. In this work, we employ newly available data of the NA49 experiment at CERN, in order to recalculate the antiproton source term arising from cosmic ray spallations on the interstellar matter. We systematically account for the production of antiprotons via hyperon decay and discuss the possible impact of isospin effects on antineutron production. A detailed comparison of our calculation with the existing literature as well as with Monte Carlo based evaluations of the antiproton source term is provided. Our most important result is an updated prediction for the secondary antiproton flux which includes a realistic assessment of the particle physics uncertainties at all energies

  15. Beam position pickup for antiprotons to the ISR

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    The Antiproton Project, launched for proton-antiproton collisions in the SPS (SPS collider), had a side-line for p-pbar collisions in the ISR. A new transfer line, TT6, was constructed to transport antiprotons from the 26 GeV PS to the injection line TT1 of ISR ring 2. Antiprotons were a scarce commodity. For setting up the lines, beam diagnostic devices in the antiproton path had to work reliably and precisely with just a few low-intensity pilot pules: single bunches of about 2x10**9 antiprotons every few hours. Electrostatic pickup electrodes were used to measure beam position. They could be mounted for measurement in the horizontal plane, as in this picture, or at 90 deg, for the vertical plane.

  16. Collisions of antiprotons with hydrogen molecular ions

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2009-01-01

    method are applied in order to describe the target molecule and the collision process. It is shown that three perpendicular orientations of the molecular axis with respect to the trajectory are sufficient to accurately reproduce the ionization cross section calculated by Sakimoto [Phys. Rev. A 71, 062704......Time-dependent close-coupling calculations of the ionization and excitation cross section for antiproton collisions with molecular hydrogen ions are performed in an impact energy range from 0.5 keV to 10 MeV. The Born-Oppenheimer and Franck-Condon approximations as well as the impact parameter...... (2005)] reducing the numerical effort drastically. The independent-event model is employed to approximate the cross section for double ionization and H+ production in antiproton collisions with H2....

  17. A new approach to experiments with non-relativistic antiprotons

    International Nuclear Information System (INIS)

    Is low-energy antiproton physics phasing out with the present round of experiments or are there good reasons to continue at an improved slow antiproton facility which could be located at a high intensity hadron accelerator? We point out, that there are four frontiers where substantial advances could be made. In particular, we discuss the low-energy frontier and emphasize that experiments with no-relativistic antiprotons would increase drastically the sensitivity and would reveal new effects. (orig.)

  18. Antiproton production in relativistic Si-nucleus collisions

    International Nuclear Information System (INIS)

    We have measured antiproton production cross sections as functions of centrality in collisions of 14.6 GeV/c per nucleon 28Si ions with targets of Al, Cu, and Pb. For all targets, the antiproton yields increase linearly with the number of projectile nucleons that have interacted, and show little target dependence. We discuss the implications of this result on the production and absorption of antiprotons within the nuclear medium

  19. An antiproton catalyst for inertial confinement fusion propulsion

    Science.gov (United States)

    Lewis, Raymond A.; Newton, Richard; Smith, Gerald A.; Toothacker, William S.; Kanzleiter, Randall J.

    1990-01-01

    This paper discusses the concept of an inertial confinement fusion propulsion system involving an antiproton catalyst (for antiproton-induced fission). It is argued that, when the two processes, fusion and antimatter annihilation, are combined into one system, a viable candidate propulsion system for planetary exploration emerges. It is shown that as much as 7.6 GW of power, well within the requrements for interplanetary travel, can be achieved using existing driver technologies and available quantities of antiprotons.

  20. Kaons and antiproton-nucleus scattering

    CERN Document Server

    Haque, S; Rahman, S N

    2003-01-01

    The elastic scattering of Kaons and antiprotons from several nuclei is studied in the framework of the generalized diffraction model due to Frahn and Venter. The systematics of reaction cross section and the standard nuclear radius, as given by the model, are discussed. The parameters obtained from the elastic scattering analyses are used, without any adjustment, to reproduce some inelastic scattering angular distributions and the corresponding deformation parameters are determined.

  1. Magnetic horn of the Antiproton Accumulator (AA)

    CERN Multimedia

    Photographic Service

    1988-01-01

    In the 1960s, the invention of this "current sheet lens" has helped to greatly improve the flux of neutrino beams. It was used again at the AA, collecting antiprotons from the production target at angles too large to fit into the acceptance of the AA. It was machined from aluminium to a thickness of 1.4 mm and pulsed at 400 kA for 15 microseconds (half-sine).

  2. Antiproton Powered Gas Core Fission Rocket

    International Nuclear Information System (INIS)

    Extensive research in recent years has demonstrated that 'at rest' annihilation of antiprotons in the uranium isotope U238 leads to fission at nearly 100% efficiency. The resulting highly-ionizing, energetic fission fragments can heat a suitable medium to very high temperatures, making such a process particularly suitable for space propulsion applications. Such an ionized medium, which would serve as a propellant, can be confined by a magnetic field during the heating process, and subsequently ejected through a magnetic nozzle to generate thrust. The gasdynamic mirror (GDM) magnetic configuration is especially suited for this application since the underlying confinement principle is that the plasma be of such density and temperature as to make the ion-ion collision mean free path shorter than the plasma length. Under these conditions the plasma behaves like a fluid, and its escape from the system is analogous to the flow of a gas into vacuum from a vessel with a hole. For the system we propose we envisage radially injecting atomic or U238 plasma beam at a pre-determined position and axially pulsing an antiproton beam which upon interaction with the uranium target gives rise to near isotropic ejection of fission fragments with a total mass of 212 amu and total energy of about 160 MeV. These particles, along with the annihilation products (i.e. pions and muons) will heat the background U238 gas - inserted into the chamber just prior to the release of the antiproton - to one keV temperature. Preliminary analysis reveals that such a propulsion system can produce a specific impulse of about 3000 seconds at a thrust of about 50 kN. When applied to a round trip Mars mission, we find that such a journey can be accomplished in about 142 days with 2 days of thrusting and requiring only one gram of antiprotons to achieve it

  3. Antiproton Powered Gas Core Fission Rocket

    Science.gov (United States)

    Kammash, T.

    Extensive research in recent years has demonstrated that “at rest” annihilation of antiprotons in the uranium isotope U238 leads to fission at nearly 100% efficiency. The resulting highly-ionizing, energetic fission fragments can heat a suitable medium to very high temperatures, making such a process particularly suitable for space propulsion applications. Such an ionized medium, which would serve as a propellant, can be confined by a magnetic field during the heating process, and subsequently ejected through a magnetic nozzle to generate thrust. The gasdynamic mirror (GDM) magnetic configuration is especially suited for this application since the underlying confinement principle is that the plasma be of such density and temperature as to make the ion-ion collision mean free path shorter than the plasma length. Under these conditions the plasma behaves like a fluid, and its escape from the system is analogous to the flow of a gas into vacuum from a vessel with a hole. For the system we propose we envisage radially injecting atomic or U238 plasma beam at a pre-determined position and axially pulsing an antiproton beam which upon interaction with the uranium target gives rise to near isotropic ejection of fission fragments with a total mass of 212 amu and total energy of about 160 MeV. These particles, along with the annihilation products (i.e. pions and muons) will heat the background U238 gas - inserted into the chamber just prior to the release of the antiproton - to one keV temperature. Preliminary analysis reveals that such a propulsion system can produce a specific impulse of about 3000 seconds at a thrust of about 50 kN. When applied to a round trip Mars mission, we find that such a journey can be accomplished in about 142 days with 2 days of thrusting and requiring only one gram of antiprotons to achieve it.

  4. Shielding calculations for the antiproton target area

    International Nuclear Information System (INIS)

    Shielding calculations performed in conjunction with the design of the Fermilab antiproton target hall are summarized. The following radiological considerations were examined: soil activation, residual activity of components, and beam-on radiation. In addition, at the request of the designers, the energy deposition in the proposed graphite beam dump was examined for several targeting conditions in order to qualitatively determine its ability to survive

  5. Measurements of Cosmic Ray Antiprotons with PAMELA

    OpenAIRE

    Wu, Juan

    2010-01-01

    The PAMELA experiment is a satellite-borne apparatus designed to study charged particles, and especially antiparticles, in the cosmic radiation. The apparatus is mounted on the Resurs DK1 satellite which was launched on 15 June 2006. PAMELA has been traveling around the earth along an elliptical and semi-polar orbit for almost five years. It mainly consists of a permanent magnetic spectrometer, a time of flight system and an electromagnetic imaging calorimeter, which allows antiprotons to be ...

  6. Looking for new gravitational forces with antiprotons

    International Nuclear Information System (INIS)

    Quite general arguments based on the principle of equivalence and modern field theory show that it is possible for the gravitational acceleration of antimatter to be different than that for matter. Further, there is no experimental evidence to rule out the possibility. In fact, some evidence indicates there may be unexpected effects. Thus, the planned experiment to measure the gravitational acceleration of antiprotons is of fundamental importance. 20 refs., 3 figs

  7. Kaons and antiproton-nucleus scattering

    International Nuclear Information System (INIS)

    The elastic scattering of Kaons and antiprotons from several nuclei is studied in the framework of the generalized diffraction model due to Frahn and Venter. The systematics of reaction cross section and the standard nuclear radius, as given by the model, are discussed. The parameters obtained from the elastic scattering analyses are used, without any adjustment, to reproduce some inelastic scattering angular distributions and the corresponding deformation parameters are determined. (author)

  8. The Facility for Antiproton and Ion Research

    Science.gov (United States)

    Langanke, K.

    2015-11-01

    In the coming years the Facility for Antiproton and Ion Research FAIR will be constructed at the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. This new accelerator complex will allow for unprecedented and path-breaking research in hadronic, nuclear and atomic physics as well as applied sciences. This manuscript will discuss some of these research opportunities, with a focus on nuclear physics related to supernova dynamics and nucleosynthesis.

  9. Radiation-induced rib fracture after stereotactic body radiotherapy with a total dose of 54–56 Gy given in 9–7 fractions for patients with peripheral lung tumor: impact of maximum dose and fraction size

    International Nuclear Information System (INIS)

    Radiation-induced rib fracture after stereotactic body radiotherapy (SBRT) for lung cancer has been recently reported. However, incidence of radiation-induced rib fracture after SBRT using moderate fraction sizes with a long-term follow-up time are not clarified. We examined incidence and risk factors of radiation-induced rib fracture after SBRT using moderate fraction sizes for the patients with peripherally located lung tumor. During 2003–2008, 41 patients with 42 lung tumors were treated with SBRT to 54–56 Gy in 9–7 fractions. The endpoint in the study was radiation-induced rib fracture detected by CT scan after the treatment. All ribs where the irradiated doses were more than 80% of prescribed dose were selected and contoured to build the dose-volume histograms (DVHs). Comparisons of the several factors obtained from the DVHs and the probabilities of rib fracture calculated by Kaplan-Meier method were performed in the study. Median follow-up time was 68 months. Among 75 contoured ribs, 23 rib fractures were observed in 34% of the patients during 16–48 months after SBRT, however, no patients complained of chest wall pain. The 4-year probabilities of rib fracture for maximum dose of ribs (Dmax) more than and less than 54 Gy were 47.7% and 12.9% (p = 0.0184), and for fraction size of 6, 7 and 8 Gy were 19.5%, 31.2% and 55.7% (p = 0.0458), respectively. Other factors, such as D2cc, mean dose of ribs, V10–55, age, sex, and planning target volume were not significantly different. The doses and fractionations used in this study resulted in no clinically significant rib fractures for this population, but that higher Dmax and dose per fraction treatments resulted in an increase in asymptomatic grade 1 rib fractures

  10. Anti-protons in the primary cosmic radiation

    International Nuclear Information System (INIS)

    A knowledge of the flux of antiprotons is of value in examining the manner in which cosmic rays propagate, assuming, as is conventional, that the antiprotons arise from interactions in the I.S.M. A comparison of observed and expected anti p/p ratios is made. (Auth.)

  11. Experiment to measure the gravitational force on the antiproton

    International Nuclear Information System (INIS)

    A collaboration has been formed to measure the acceleration of antiprotons in the earth's gravitational field. The technique is to produce, decelerate, and trap quantities of antiprotons, to cool them to untralow energy, and to measure their acceleration in a time-of-flight experiment. Present plans and the results of initial efforts toward this end are presented

  12. A study of the reactions antiproton-d→antiproton-dπ+π- and antiproton-d→psub(s)antiproton-pπ- at 14.6 GeV/c and a study of charged multiplicity distributions

    International Nuclear Information System (INIS)

    An analysis of two reactions on deuterium has been performed with incident antiprotons of 14.6 GeV/c: antiproton-d→antiproton-dπ+π- and antiproton-d→psub(s)antiproton-pπ-. The final states are dominated by Δ(1236) resonance production and in the coherent reaction the d* effect is observed as at lower incident momenta. At 14.6 GeV/c, it seems that the diffraction dissociation process as well for the incident particle as for the target takes a large part of the production mechanism for the two reactions. A study of charged multiplicity distributions in antiproton-neutron interactions is presented at 5.5, 9.3 and 14.6 GeV/c. The topological cross sections as well as various statistical moments obtained from the charged multiplicities are studied as functions of the incident momentum. A comparison between our results and antiproton-proton and pp data shows, that in the range of incident momenta used, a scaling function which describes antiproton-N and proton-proton interactions does not exist as expected from the KNO model (Koba-Nielsen-Olesen model)

  13. Physics overview of the Fermilab Low Energy Antiproton Facility Workshop

    International Nuclear Information System (INIS)

    A physics overview is presented of the Fermilab workshop to consider a possible high flux, low energy antiproton facility that would use cooled antiprotons from the accumulator ring of the Tevatron collider. Two examples illustrate the power of each a facility to produce narrow states at high rates. Physics topics to which such a facility may be applied are reviewed

  14. Wave Packet Simulations of Antiproton Scattering on Molecular Hydrogen

    OpenAIRE

    Stegeby, Henrik; Kowalewski, Markus; Piszczatowski, Konrad; Karlsson, Hans O.

    2015-01-01

    The problem of antiproton scattering on the molecular Hydrogen is investigated by means of wave packet dynamics. The electronically potential energy surfaces of the antiproton H2 system are presented within this work. Excitation and dissociation probabilities of the molecular Hydrogen for collision energies in the ultra low energy regime below 10 eV are computed.

  15. Serach for polarization effects in the antiproton production process

    CERN Multimedia

    It is proposed to study polarization effects in the production of antiprotons at the PS test beam line T11 at 3.5 GeV/c momentum. A polarization in the production process has never been studied but if existing it would allow for a rather simple and cheap way to generate a polarized antiproton beam with the existing facilities at CERN.

  16. Antiproton cloud compression in the ALPHA apparatus at CERN

    International Nuclear Information System (INIS)

    We have observed a new mechanism for compression of a non-neutral plasma, where antiprotons embedded in an electron plasma are compressed by a rotating wall drive at a frequency close to the sum of the axial bounce and rotation frequencies. The radius of the antiproton cloud is reduced by up to a factor of 20 and the smallest radius measured is ∼ 0.2 mm. When the rotating wall drive is applied to either a pure electron or pure antiproton plasma, no compression is observed in the frequency range of interest. The frequency range over which compression is evident is compared to the sum of the antiproton bounce frequency and the system’s rotation frequency. It is suggested that bounce resonant transport is a likely explanation for the compression of antiproton clouds in this regime

  17. Detailed analysis of observed antiprotons in cosmic rays

    Directory of Open Access Journals (Sweden)

    P Davoudifar

    2009-12-01

    Full Text Available In the present work, the origin of antiprotons observed in cosmic rays (above the atmosphere is analyzed in details. We have considered the origin of the primaries, (which their interactions with the interstellar medium is one of the most important sources of antiprotons is a supernova type II then used a diffusion model for their propagation. We have used the latest parameterization for antiproton production cross section in pp collisions (instead of well known parameterization introduced by Tan et al. as well as our calculated residence time for primaries. The resulted intensity shows the secondary antiprotons produced in pp collisions in the galaxy, have a high population as one can not consider an excess for extragalactic antiprotons. Also there is a high degree of uncertainty in different parameters.

  18. Antiproton cloud compression in the ALPHA apparatus at CERN

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez, A., E-mail: andrea.gutierrez@triumf.ca [University of British Columbia, Department of Physics and Astronomy (Canada); Ashkezari, M. D. [Simon Fraser University, Department of Physics (Canada); Baquero-Ruiz, M. [University of California at Berkeley, Department of Physics (United States); Bertsche, W. [University of Manchester, School of Physics and Astronomy (United Kingdom); Burrows, C. [Swansea University, Department of Physics, College of Science (United Kingdom); Butler, E. [Centre for Cold Matter, Imperial College (United Kingdom); Capra, A. [York University, Department of Physics and Astronomy (Canada); Cesar, C. L. [Universidade Federal do Rio de Janeiro, Instituto de Física (Brazil); Charlton, M. [Swansea University, Department of Physics, College of Science (United Kingdom); Dunlop, R. [Simon Fraser University, Department of Physics (Canada); Eriksson, S. [Swansea University, Department of Physics, College of Science (United Kingdom); Evetts, N. [University of British Columbia, Department of Physics and Astronomy (Canada); Fajans, J. [University of California at Berkeley, Department of Physics (United States); Friesen, T. [Aarhus University, Department of Physics and Astronomy (Denmark); Fujiwara, M. C.; Gill, D. R. [TRIUMF (Canada); Hangst, J. S. [Aarhus University, Department of Physics and Astronomy (Denmark); Hardy, W. N. [University of British Columbia, Department of Physics and Astronomy (Canada); Hayden, M. E. [Simon Fraser University, Department of Physics (Canada); Isaac, C. A. [Swansea University, Department of Physics, College of Science (United Kingdom); and others

    2015-11-15

    We have observed a new mechanism for compression of a non-neutral plasma, where antiprotons embedded in an electron plasma are compressed by a rotating wall drive at a frequency close to the sum of the axial bounce and rotation frequencies. The radius of the antiproton cloud is reduced by up to a factor of 20 and the smallest radius measured is ∼ 0.2 mm. When the rotating wall drive is applied to either a pure electron or pure antiproton plasma, no compression is observed in the frequency range of interest. The frequency range over which compression is evident is compared to the sum of the antiproton bounce frequency and the system’s rotation frequency. It is suggested that bounce resonant transport is a likely explanation for the compression of antiproton clouds in this regime.

  19. Intensity-Frontier Antiproton Physics with The Antiproton Annihilation Spectrometer (TAPAS) at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Apollinari, Giorgio; /Fermilab; Asner, David M.; /PNL, Richland; Baldini, Wander; /INFN, Ferrara; Bartoszek, Larry; Broemmelsiek, Daniel R.; Brown, Charles N.; /Fermilab; Chakravorty, Alak; /St. Xavier U., Chicago; Colas, Paul; /Saclay; Derwent, Paul; /Fermilab; Drutskoy, Alexey; /Moscow, ITEP; Fortner, Michael; /Northern Illinois U. /Saclay /Indian Inst. Tech., Hyderabad

    2011-11-01

    The Fermilab Antiproton Source is the world's most intense source of antimatter. With the Tevatron program now behind us, this unique facility can help make the case for Fermilab's continued accelerator operations. The Antiproton Source can be used for unique, dedicated antimatter studies, including medium-energy {bar p}-annihilation experiments. We propose to assemble a powerful, yet cost-effective, solenoidal magnetic spectrometer for antiproton-annihilation events, and to use it at the Fermilab Antiproton Accumulator to measure the charm production cross section, study rare hyperon decays, search for hyperon CP asymmetry, precisely measure the properties of several charmonium and nearby states, and make the first measurements of the Drell-Yan continuum in medium-energy antiproton annihilation. Should the charm production cross section be as large as some have proposed, we will also be able to measure D{sup 0}-{bar D}{sup 0} mixing with high precision and discover (or sensitively limit) charm CP violation. The observation of charm or hyperon CP violation would be evidence for physics beyond the Standard Model, with possible implications for the origin of the baryon asymmetry of the universe - the question of what happened to all the antimatter that must have been produced in the Big Bang. The experiment will be carried out by an international collaboration and will require some four years of running time. As possibly the sole hadron experiment in progress at Fermilab during that time, it will play an important role in maintaining a broad particle physics program at Fermilab and in the U.S. It will thus help us to continue attracting creative and capable young people into science and technology, and introducing them to the important technologies of accelerators, detectors, and data acquisition and analysis - key roles in society that accelerator-based particle physics has historically played.

  20. Scaling properties of proton and antiproton production in sqrt[s(NN)]=200 GeV Au+Au collisions.

    Science.gov (United States)

    Adler, S S; Afanasiev, S; Aidala, C; Ajitanand, N N; Akiba, Y; Alexander, J; Amirikas, R; Aphecetche, L; Aronson, S H; Averbeck, R; Awes, T C; Azmoun, R; Babintsev, V; Baldisseri, A; Barish, K N; Barnes, P D; Bassalleck, B; Bathe, S; Batsouli, S; Baublis, V; Bazilevsky, A; Belikov, S; Berdnikov, Y; Bhagavatula, S; Boissevain, J G; Borel, H; Borenstein, S; Brooks, M L; Brown, D S; Bruner, N; Bucher, D; Buesching, H; Bumazhnov, V; Bunce, G; Burward-Hoy, J M; Butsyk, S; Camard, X; Chai, J-S; Chand, P; Chang, W C; Chernichenko, S; Chi, C Y; Chiba, J; Chiu, M; Choi, I J; Choi, J; Choudhury, R K; Chujo, T; Cianciolo, V; Cobigo, Y; Cole, B A; Constantin, P; d'Enterria, D G; David, G; Delagrange, H; Denisov, A; Deshpande, A; Desmond, E J; Dietzsch, O; Drapier, O; Drees, A; du Rietz, R; Durum, A; Dutta, D; Efremenko, Y V; El Chenawi, K; Enokizono, A; En'yo, H; Esumi, S; Ewell, L; Fields, D E; Fleuret, F; Fokin, S L; Fox, B D; Fraenkel, Z; Frantz, J E; Franz, A; Frawley, A D; Fung, S-Y; Garpman, S; Ghosh, T K; Glenn, A; Gogiberidze, G; Gonin, M; Gosset, J; Goto, Y; Granier de Cassagnac, R; Grau, N; Greene, S V; Grosse Perdekamp, G; Guryn, W; Gustafsson, H-A; Hachiya, T; Haggerty, J S; Hamagaki, H; Hansen, A G; Hartouni, E P; Harvey, M; Hayano, R; He, X; Heffner, M; Hemmick, T K; Heuser, J M; Hibino, M; Hill, J C; Holzmann, W; Homma, K; Hong, B; Hoover, A; Ichihara, T; Ikonnikov, V V; Imai, K; Isenhower, L D; Ishihara, M; Issah, M; Isupov, A; Jacak, B V; Jang, W Y; Jeong, Y; Jia, J; Jinnouchi, O; Johnson, B M; Johnson, S C; Joo, K S; Jouan, D; Kametani, S; Kamihara, N; Kang, J H; Kapoor, S S; Katou, K; Kelly, S; Khachaturov, B; Khanzadeev, A; Kikuchi, J; Kim, D H; Kim, D J; Kim, D W; Kim, E; Kim, G-B; Kim, H J; Kistenev, E; Kiyomichi, A; Kiyoyama, K; Klein-Boesing, C; Kobayashi, H; Kochenda, L; Kochetkov, V; Koehler, D; Kohama, T; Kopytine, M; Kotchetkov, D; Kozlov, A; Kroon, P J; Kuberg, C H; Kurita, K; Kuroki, Y; Kweon, M J; Kwon, Y; Kyle, G S; Lacey, R; Ladygin, V; Lajoie, J G; Lebedev, A; Leckey, S; Lee, D M; Lee, S; Leitch, M J; Li, X H; Lim, H; Litvinenko, A; Liu, M X; Liu, Y; Maguire, C F; Makdisi, Y I; Malakhov, A; Manko, V I; Mao, Y; Martinez, G; Marx, M D; Masui, H; Matathias, F; Matsumoto, T; McGaughey, P L; Melnikov, E; Messer, F; Miake, Y; Milan, J; Miller, T E; Milov, A; Mioduszewski, S; Mischke, R E; Mishra, G C; Mitchell, J T; Mohanty, A K; Morrison, D P; Moss, J M; Mühlbacher, F; Mukhopadhyay, D; Muniruzzaman, M; Murata, J; Nagamiya, S; Nagle, J L; Nakamura, T; Nandi, B K; Nara, M; Newby, J; Nilsson, P; Nyanin, A S; Nystrand, J; O'Brien, E; Ogilvie, C A; Ohnishi, H; Ojha, I D; Okada, K; Ono, M; Onuchin, V; Oskarsson, A; Otterlund, I; Oyama, K; Ozawa, K; Pal, D; Palounek, A P T; Pantuev, V S; Papavassiliou, V; Park, J; Parmar, A; Pate, S F; Peitzmann, T; Peng, J-C; Peresedov, V; Pinkenburg, C; Pisani, R P; Plasil, F; Purschke, M L; Purwar, A; Rak, J; Ravinovich, I; Read, K F; Reuter, M; Reygers, K; Riabov, V; Riabov, Y; Roche, G; Romana, A; Rosati, M; Rosnet, P; Ryu, S S; Sadler, M E; Saito, N; Sakaguchi, T; Sakai, M; Sakai, S; Samsonov, V; Sanfratello, L; Santo, R; Sato, H D; Sato, S; Sawada, S; Schutz, Y; Semenov, V; Seto, R; Shaw, M R; Shea, T K; Shibata, T-A; Shigaki, K; Shiina, T; Silva, C L; Silvermyr, D; Sim, K S; Singh, C P; Singh, V; Sivertz, M; Soldatov, A; Soltz, R A; Sondheim, W E; Sorensen, S P; Sourikova, I V; Staley, F; Stankus, P W; Stenlund, E; Stepanov, M; Ster, A; Stoll, S P; Sugitate, T; Sullivan, J P; Takagui, E M; Taketani, A; Tamai, M; Tanaka, K H; Tanaka, Y; Tanida, K; Tannenbaum, M J; Tarján, P; Tepe, J D; Thomas, T L; Tojo, J; Torii, H; Towell, R S; Tserruya, I; Tsuruoka, H; Tuli, S K; Tydesjö, H; Tyurin, N; Van Hecke, H W; Velkovska, J; Velkovsky, M; Villatte, L; Vinogradov, A A; Volkov, M A; Vznuzdaev, E; Wang, X R; Watanabe, Y; White, S N; Wohn, F K; Woody, C L; Xie, W; Yang, Y; Yanovich, A; Yokkaichi, S; Young, G R; Yushmanov, I E; Zajc, W A; Zhang, C; Zhou, S; Zolin, L

    2003-10-24

    We report on the yield of protons and antiprotons, as a function of centrality and transverse momentum, in Au+Au collisions at sqrt[s(NN)]=200 GeV measured at midrapidity by the PHENIX experiment at the BNL Relativistic Heavy Ion Collider. In central collisions at intermediate transverse momenta (1.5antiprotons. They show a centrality-scaling behavior different from that of pions. The pmacr;/pi and p/pi ratios are enhanced compared to peripheral Au+Au, p+p, and e(+)e(-) collisions. This enhancement is limited to p(T)<5 GeV/c as deduced from the ratio of charged hadrons to pi(0) measured in the range 1.5

  1. Study of hyperon-antihyperon production in antiproton-proton collision at 4 GeV/c

    International Nuclear Information System (INIS)

    We present the results on hyperon-antihyperon production by 4 GeV/c antiprotons in hydrogen. We used about 105 pictures taken in an antiproton beam from the CERN proton synchrotron with the 81 cm Saclay hydrogen bubble chamber. The aim of this work was the study, through the cross sections and the angular distributions, of production mechanism of hyperon antihyperon pairs and excited hyperons (or antihyperons). For most of the channels, these angular distributions show a strong forward peaking of the antihyperon in the center of mass of the interaction. This suggests that a peripheral-type mechanism is predominant in these processes. We compare the results of some cross sections, with theoretical predictions according to SU3 unitary symmetry. (author)

  2. LEAP [Low-Energy Antiproton]: A balloon-borne search for low-energy cosmic-ray antiprotons

    International Nuclear Information System (INIS)

    The LEAP (Low-Energy Antiproton) experiment is a search for cosmic-ray antiprotons in the 120 MeV to 1.2 GeV kinetic energy range. The motivation for this project was the result announced by Buffington et. al. (1981) that indicated an anomalously high antiproton flux below 300 MeV; this result has compelled theorists to propose sources of primary antiprotons above the small secondary antiproton flux produced by high energy cosmic-ray collisions with nuclei in the interstellar medium. LEAP consisted of the NMSU magnetic spectrometer, a time-of-flight system designed at Goddard Space Flight Center, two scintillation detectors, and a Cherenkov counter designed and built at the University of Arizona. Analysis of flight data performed by the high-energy astrophysics group at Goddard Space Flight Center revealed no antiproton candidates found in the 120 MeV to 360 MeV range; 3 possible antiproton candidate events were found in the 500 MeV to 1.2 GeV range in an analysis done here at the University of Arizona. However, since it will be necessary to sharpen the calibration on all of the LEAP systems in order to positively identify these events as antiprotons, only an upper limit has been determined at present. Thus, combining the analyses performed at the University of Arizona and Goddard Space Flight Center, 90% confidence upper limits of 3.5 x 10-5 in the 120 MeV to 360 MeV range and 2.3 x 10-4 in the 500 MeV to 1.2 GeV range for the antiproton/proton ratio is indicated by the LEAP results. LEAP disagrees sharply with the results of the Buffington group, indicating a low antiproton flux at these energies

  3. Laser Spectroscopy of Antiprotonic Helium Atoms

    CERN Multimedia

    2002-01-01

    %PS205 %title\\\\ \\\\Following the discovery of metastable antiprotonic helium atoms ($\\overline{p}He^{+} $) at KEK in 1991, systematic studies of their properties were made at LEAR from 1991 to 1996. In the first two years the lifetime of $\\overline{p}He^{+}$ in liquid and gaseous helium at various temperatures and pressures was measured and the effect of foreign gases on the lifetime of these atoms was investigated. Effects were also discovered which gave the antiproton a 14\\% longer lifetime in $^4$He than in $^3$He, and resulted in important differences in the shape of the annihilation time spectra in the two isotopes.\\\\ \\\\Since 1993 laser spectroscopy of the metastable $\\overline{p}He^{+}$ atoms became the main focus of PS205. Transitions were stimulated between metastable and non-metastable states of the $\\overline{p}He^{+}$ atom by firing a pulsed dye laser beam into the helium target every time an identified metastable atom was present (Figure 1). If the laser frequency matched the transition energy, the...

  4. Annihilation of low energy antiprotons in silicon

    CERN Document Server

    Aghion, S; Belov, A S; Bonomi, G; Bräunig, P; Bremer, J; Brusa, R S; Burghart, G; Cabaret, L; Caccia, M; Canali, C; Caravita, R; Castelli, F; Cerchiari, G; Cialdi, S; Comparat, D; Consolati, G; Derking, J H; Di Domizio, S; Di Noto, L; Doser, M; Dudarev, A; Ferragut, R; Fontana, A; Genova, P; Giammarchi, M; Gligorova, A; Gninenko, S N; Haider, S; Harasimovic, J; Huse, T; Jordan, E; Jørgensen, L V; Kaltenbacher, T; Kellerbauer, A; Knecht, A; Krasnický, D; Lagomarsino, V; Magnani, A; Mariazzi, S; Matveev, V A; Moia, F; Nebbia, G; Nédélec, P; Pacifico, N; Petrácek, V; Prelz, F; Prevedelli, M; Regenfus, C; Riccardi, C; Røhne, O; Rotondi, A; Sandaker, H; Susa, A; Vasquez, M A Subieta; Špacek, M; Testera, G; Welsch, C P; Zavatarelli, S

    2013-01-01

    The goal of the AE$\\mathrm{\\bar{g}}$IS experiment at the Antiproton Decelerator (AD) at CERN, is to measure directly the Earth's gravitational acceleration on antimatter. To achieve this goal, the AE$\\mathrm{\\bar{g}}$IS collaboration will produce a pulsed, cold (100 mK) antihydrogen beam with a velocity of a few 100 m/s and measure the magnitude of the vertical deflection of the beam from a straight path. The final position of the falling antihydrogen will be detected by a position sensitive detector. This detector will consist of an active silicon part, where the annihilations take place, followed by an emulsion part. Together, they allow to achieve 1$%$ precision on the measurement of $\\bar{g}$ with about 600 reconstructed and time tagged annihilations. We present here, to the best of our knowledge, the first direct measurement of antiproton annihilation in a segmented silicon sensor, the first step towards designing a position sensitive silicon detector for the AE$\\mathrm{\\bar{g}}$IS experiment. We also pr...

  5. Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study

    International Nuclear Information System (INIS)

    A phase III multi-centre randomised trial (ROSEL) has been initiated to establish the role of stereotactic radiotherapy in patients with operable stage IA lung cancer. Due to rapid changes in radiotherapy technology and evolving techniques for image-guided delivery, guidelines had to be developed in order to ensure uniformity in implementation of stereotactic radiotherapy in this multi-centre study. A Quality Assurance Working Party was formed by radiation oncologists and clinical physicists from both academic as well as non-academic hospitals that had already implemented stereotactic radiotherapy for lung cancer. A literature survey was conducted and consensus meetings were held in which both the knowledge from the literature and clinical experience were pooled. In addition, a planning study was performed in 26 stage I patients, of which 22 were stage 1A, in order to develop and evaluate the planning guidelines. Plans were optimised according to parameters adopted from RTOG trials using both an algorithm with a simple homogeneity correction (Type A) and a more advanced algorithm (Type B). Dose conformity requirements were then formulated based on these results. Based on current literature and expert experience, guidelines were formulated for this phase III study of stereotactic radiotherapy versus surgery. These guidelines can serve to facilitate the design of future multi-centre clinical trials of stereotactic radiotherapy in other patient groups and aid a more uniform implementation of this technique outside clinical trials

  6. Peripheral Neuropathy

    Science.gov (United States)

    ... can be associated with peripheral neuropathy. Metabolic and endocrine disorders impair the body’s ability to transform nutrients into ... to neuropathies as a result of chemical imbalances. Endocrine disorders that lead to hormonal imbalances can disturb normal ...

  7. Peripheral Neuropathy

    Science.gov (United States)

    ... injury (trauma) to a nerve, tumors, toxins, autoimmune responses, nutritional deficiencies, alcoholism, medical procedures, and vascular and metabolic disorders. Acquired peripheral neuropathies are caused by systemic disease, trauma from external agents, or infections or autoimmune disorders ...

  8. A new antiproton beam transfer scheme without coalescing

    Energy Technology Data Exchange (ETDEWEB)

    Weiren Chou et al.

    2003-06-04

    An effective way to increase the luminosity in the Fermilab Tevatron collider program Run2 is to improve the overall antiproton transfer efficiency. During antiproton coalescing in the Main Injector (MI), about 10-15% particles get lost. This loss could be avoided in a new antiproton transfer scheme that removes coalescing from the process. Moreover, this scheme would also eliminate emittance dilution due to coalescing. This scheme uses a 2.5 MHz RF system to transfer antiprotons from the Accumulator to the Main Injector. It is then followed by a bunch rotation in the MI to shorten the bunch length so that it can be captured by a 53 MHz RF bucket. Calculations and ESME simulations show that this scheme works. No new hardware is needed to implement this scheme.

  9. Antiproton cell experiment: antimatter is a better killer

    CERN Document Server

    2006-01-01

    "European Organization for Nuclear Research is reporting that results from a three year study of antiprotons for neoplasm irrdiation showed a better cellular killer with a smaller lethal dose." (1,5 page)

  10. Do positrons and antiprotons respect the weak equivalence principle?

    International Nuclear Information System (INIS)

    We resolve the difficulties which Morrison identified with energy conservation and the gravitational red-shift when particles of antimatter, such as the positron and antiproton, do not respect the weak equivalence principle. 13 refs

  11. Antiprotons from dark matter annihilation in the Galaxy: astrophysical uncertainties

    CERN Document Server

    Evoli, Carmelo; Grasso, Dario; Maccione, Luca; Ullio, Piero

    2011-01-01

    The latest years have seen steady progresses in WIMP dark matter (DM) searches, with hints of possible signals suggested by both direct and indirect detection experiments. Antiprotons can play a key role validating those interpretations since they are copiously produced by WIMP annihilations in the Galactic halo, and the secondary antiproton background produced by Cosmic Ray (CR) interactions is predicted with fair accuracy and matches the observed spectrum very well. Using the publicly available numerical DRAGON code, we reconsider antiprotons as a tool to constrain DM models discussing its power and limitations. We provide updated constraints on a wide class of annihilating DM models by comparing our predictions against the most up-to-date ap measurements, taking also into account the latest spectral information on the p, He and other CR nuclei fluxes. Doing that, we probe carefully the uncertainties associated to both secondary and DM originated antiprotons, by using a variety of distinctively different as...

  12. Proceedings of the Antiproton Technology Workshop held in Upton, New York on 10 May 1989

    Science.gov (United States)

    Nordley, Gerald D.

    1989-05-01

    Titles of presentations included: Stopping Power of MeV Proton and Antiproton Beams; Recent Simulation Results of ASTER; Pbar Testing of Hydrogen Effects in Sealed Carbon-Carbon Composites; Potential for Antiprotons in Radiation Oncology; Prospects for a Commercial Antiproton Source; Prospects for Exciting Extreme States in Nuclear Matter with Intense Antiproton Beams; Status of AL Studies Relating to Condensed Antimatter; Electromagnetic Traps for Atomic Antihydrogen; Antihydrogen Production; Headquarters DoE Antiproton Activities; Antiproton Catalyzed Fusion; Antiproton Induced Fusion Reaction; Options for a Laboratory Microfusion Facility; Modeling Antiproton-Plasma Interactions; Concepts for Experimental Determination of Radiation Shielding and Metal Clad Pellet Performance; Introduction to CP Violation Studies with Pbars; Search for CP Violation in Pbar-P to J/psi; Studies of Rare Models of Pbar-P Annihilation; and Antiproton Production Calculation by the Multistring Model VENUS Computer Code.

  13. Rescattering effects in antiproton deuteron annihilation at intermediate energies

    International Nuclear Information System (INIS)

    In this paper higher order corrections to the single scattering term for antiproton deuteron annihilation are evaluated. As dominant corrections the initial state interaction of the antiprotons and the rescattering of pions are considered. For low spectator momenta, these corrections cause a strong modulation of the distribution in the invariant mass of the annihilation pions, which could modify the parameters of the resonant baryonium states

  14. Antiproton-proton annihilation at rest into two mesons

    International Nuclear Information System (INIS)

    Branching ratios for antiproton-proton annihilations at rest into two mesons are given. The data were obtained at LEAR by stopping antiprotons in a liquid hydrogen target. Both charged and neutral annihilation products were detected in the Crystal Barrel detector. Representative data are presented, and their bearing on the general picture of annihilation dynamics is discussed. In addition, preliminary branching ratios for two-body radiative annihilations are given. (orig.)

  15. Cosmic Antiproton Constraints on Effective Interactions of the Dark Matter

    CERN Document Server

    Cheung, Kingman; Yuan, Tzu-Chiang

    2010-01-01

    Using an effective interaction approach to describe the interactions between the dark matter particle and the light degrees of freedom of the standard model, we calculate the antiproton flux due to the annihilation of the dark matter in the Galactic Halo and compare to the most recent antiproton spectrum of the PAMELA experiment. We obtain useful constraints on the size of the effective interactions that are comparable to those deduced from collider and gamma-ray experiments.

  16. Cosmic antiproton constraints on effective interactions of the dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Kingman [Division of Quantum Phases and Devices, School of Physics, Konkuk university, Seoul 143-701 (Korea, Republic of); Tseng, Po-Yan [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); Yuan, Tzu-Chiang, E-mail: cheung@phys.nthu.edu.tw, E-mail: tcyuan@phys.sinica.edu.tw, E-mail: d9722809@oz.nthu.edu.tw [Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan (China)

    2011-01-01

    Using an effective interaction approach to describe the interactions between the dark matter particle and the light degrees of freedom of the standard model, we calculate the antiproton flux due to the annihilation of the dark matter in the Galactic Halo and compare to the most recent antiproton spectrum of the PAMELA experiment. We obtain useful constraints on the size of the effective interactions that are comparable to those deduced from collider and gamma-ray experiments.

  17. Cosmic antiproton constraints on effective interactions of the dark matter

    International Nuclear Information System (INIS)

    Using an effective interaction approach to describe the interactions between the dark matter particle and the light degrees of freedom of the standard model, we calculate the antiproton flux due to the annihilation of the dark matter in the Galactic Halo and compare to the most recent antiproton spectrum of the PAMELA experiment. We obtain useful constraints on the size of the effective interactions that are comparable to those deduced from collider and gamma-ray experiments

  18. Low-energy collisions of antiprotons with atoms and molecules

    International Nuclear Information System (INIS)

    Time-dependent close-coupling calculations were performed using the impact parameter method for antiproton and proton collisions with alkali-metal atoms and hydrogen molecules. The targets are described as effective one-electron systems using appropriate model potentials. The proton data verify the employed method while the results for antiprotons improve the literature on these systems considerably. Cross sections for ionization and excitation as well as electron-energy spectra and stopping power will be presented.

  19. Electron cooling for low-energy antiprotons

    International Nuclear Information System (INIS)

    Divergence and size of stored ion beams can be reduced superimposing on them an intense, monoenergetic electron beam with little transverse motion ('electron cooling'). The present work first considers the theoretical foundations of the method and then describes the planning and construction of an electron beam device for cooling antiprotons with MeV energies in the storage ring LEAR and CERN. With respect to the quantitative description of the method, the microscopic processes during the damping of the ion motion, the effect of the damping on an ion in a storage ring, and the properties of the intense, magnetically guided electron beam are discussed. Special attention is paid to the improvement of ion beam cooling due to the magnetic field guiding the electron beam. The electron beam device, operated in ultra-high vacuum, and the experience gained during its construction are described; experiments performed during the test period are presented. The work further develops a numerical simulation of electron cooling on the basis of the theory discussed. Given realistic external parameters, the simulation yields cooling times and equilibrium states of the ion beam during electron cooling in a storage ring. Finally, non-destructive methods for measuring the velocity distribution in the electron beam are described, which may prove helpful for optimizing the beam cooling. (orig.)

  20. Antiproton-impact ionization of H2

    International Nuclear Information System (INIS)

    Ionization processes in antiproton collisions with H2 are studied by direct solution of the time-dependent Schroedinger equation. A time-dependent close-coupling method based on an expansion of a one-electron 3D wavefunction in the field of H+2 is used to calculate single-ionization cross sections at incident energies ranging from 50 keV to 1.5 MeV. Averaging over the molecular orientations, the single-ionization cross sections are in reasonable agreement with time-dependent basis set calculations and experiment. A time-dependent close-coupling method based on an expansion of a two-electron 6D wavefunction in the field of H2+2 is used to calculate single- and double-ionization cross sections at an incident energy of 100 keV. Initiatory 6D results for the H+2 production cross section range are somewhat lower than experiment, while the H+ production cross section range brackets experiment.

  1. Elastic and inelastic scattering of antiprotons

    International Nuclear Information System (INIS)

    During the last two years very interesting results have been collected at LEAR on both the elementary pantip and the antip nucleus interactions. A review of all the interesting experimental results already available is far beyond the scope of the present talk. Its topic will be essentially limited to report on the new experimental informations dealing with the knowledge of the fundamental properties of the antip p elementary interaction and the determination of the characteristics of the antip nucleus interaction. The results of the antip p cross sections measured at low momenta by the PS173 and PS172 experiments are discussed. The antip nucleus elastic scattering angular distributions collected by the PS184 experiment have significantly contributed to define the properties of the p nucleus optical potential and stimulated a lot of microscopic calculations. The results are reviewed. A comparison to the informations obtained from the measurements of X-rays in antiprotonic atoms done by the PS176 and PS186 experiments is given. The interpretation of the inelastic scattering data measured for the 12C(antip, antip)12C* system at 47 and 180 MeV for various discrete states is presented: special emphasis will be given to the study of spin-flip transitions to unnatural parity states which would provide significant constant on the isovector tensor component of the NantiN interaction. Status on the experimental study of the (antip, p) reaction is discussed

  2. Delayed annihilation of antiprotons in helium gas

    International Nuclear Information System (INIS)

    The delayed annihilation of antiprotons, which was recently discovered in liquid 4He at KEK, has been studied at CERN in gas-phase 4He and 3He. The annihilation time spectra in gas 4He at various pressures were found to be similar to that for liquid 4He. The observed average lifetime in the region t > 1μsec for 3 atm 4He was about 3.2μsec, while for 3 atm 3He gas it was 2.8μsec, i.e. shorter by 15 %. The time spectra show a growth-decay type function, which is indicative of the presence of a series of metastable states. For 4He and 3He they have nearly identical shapes, differing only in the time scale by 14 ± 3 %. These observations are qualitatively consistent with the atomic model of p-bare-He++ proposed by Condo. The time spectra were found to be sensitive to the presence of small amounts (as small as 20 ppm) of H2. No evidence was seen for delayed annihilation in gaseous Ne. 36.10. (author)

  3. Charm production in antiproton-proton annihilation

    CERN Document Server

    Haidenbauer, J

    2010-01-01

    We study the production of charmed mesons (D) and baryons (Lambda_c) in antiproton-proton (app) annihilation close to their respective production thresholds. The elementary charm production process is described by either baryon/meson exchange or by quark/gluon dynamics. Effects of the interactions in the initial and final states are taken into account rigorously. The calculations are performed in close analogy to our earlier study on app -> antiLambda-Lambda and app -> antiK-K by connecting the processes via SU(4) flavor symmetry. Our predictions for the antiLambda_c-Lambda_c production cross section are in the order of 1 to 7 mb, i.e. a factor of around 10-70 smaller than the corresponding cross sections for antiLambda-Lambda However, they are 100 to 1000 times larger than predictions of other model calculations in the literature. On the other hand, the resulting cross sections for antiD-D production are found to be in the order of 10^{-2} -- 10^{-1} microbarn and they turned out to be comparable to those ob...

  4. Antiproton trapping in various helium media: report of the HELIUMTRAP experiment at LEAR

    International Nuclear Information System (INIS)

    HELIUMTRAP (PS205) investigates the recently discovered anomalously long-lived states of antiprotons in various helium media. An overview is given of experiments stopping antiprotons in several phases of helium performed at LEAR in the last two years. (author)

  5. Spin Filtering of Stored (Anti)Protons: from FILTEX to COSY to AD to FAIR

    International Nuclear Information System (INIS)

    We review the theory of spin filtering of stored (anti)protons by multiple passage through the polarized internal target (PIT). Implications for the antiproton polarization buildup in the proposed PAX experiment at FAIR GSI are discussed

  6. Medium-Energy Antiproton Physics with the Antiproton Annihilation Spectrometer (TApAS*) at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Bartoszek, Larry; /Bartoszek Engineering, Aurora; Piacentino, Giovanni M.; /Cassino U.; Phillips, Thomas J.; /Duke U.; Apollinari, Giorgio; Broemmelsiek, Daniel R.; Brown, Charles N.; Christian, David C.; Derwent, Paul; Gollwitzer, Keith; Hahn, Alan; Papadimitriou, Vaia; /Fermilab /INFN, Pisa /Hbar Technologies, West Chicago /Houston U. /IIT, Chicago /IIT, Hyderabad /ITEP /KyungPook National U. /LPI

    2008-01-01

    We propose to assemble a cost-effective, yet powerful, solenoidal magnetic spectrometer for antiproton-annihilation events and use it at the Fermilab Antiproton Accumulator to measure the charm production cross section, study rare hyperon decays, search for hyperon CP asymmetry, and precisely measure the properties of several charmonium and nearby states. Should the charm production cross section be as large as some have proposed, we will also be able to measure D{sup 0}-{bar D}{sup 0} mixing with high precision and discover (or sensitively limit) charm CP violation. The experiment will be carried out by an international collaboration, with installation occurring during the accelerator downtime following the completion of the Tevatron run, and with funding largely from university research grants. The experiment will require some four years of running time. As possibly the sole hadron experiment in progress at Fermilab during that time, it will play an important role in maintaining a broad particle-physics program at Fermilab and in the U.S.

  7. Feasibility of an antiproton catalyzed fission fragment rocket

    Science.gov (United States)

    Hidinger, David S.

    1992-03-01

    The purpose of this project was to investigate the feasibility of an antiproton catalyzed fission fragment rocket (FFR). The FFR is characterized by the extraction of fission fragments from the fuel, and the utilization of their kinetic energy for thrust generation. A significant drawback to previous FFR designs was the required critical nuclear pile as the fission fragment source. The author examined the possibility of replacing the critical pile with a sub-critical pile driven by antiprotons. Recent experiments have revealed that antiprotons stimulate highly energetic fissions in 238U, with a neutron multiplicity of 13.7 neutrons per fissions. This interaction was used as a throttled neutron source. The pile consisted of layers of fissile coated fibers which are designed to allow fission fragments to escape them, where the fragments collide with a fluid. The heated fluid is then ejected from the rocket to provide thrust. The calculations performed indicate that each antiproton injected into the pile can stimulate 8 or more fissions while maintaining a neutron multiplication of less than 0.4. Based on the results, the specific design presented was inadequate. Despite this, the concept of using the antiproton-U interaction as a source of thrust warrants further study.

  8. Large amounts of antiproton production by heavy ion collision

    International Nuclear Information System (INIS)

    To produce large amounts of antiprotons, on the order of several grams/year, use of machines to produce nuclear collisions are studied. These can be of either proton-proton, proton-nucleus and nucleus-nucleus in nature. To achieve high luminosity colliding beams, on the order of 1041 m/cm2, a self-colliding machine is required, rather than a conventional circular colliding type. The self-colliding machine can produce additional antiprotons through successive collisions of secondary particles, such as spectator nucleons. A key problem is how to collect the produced antiprotons without capture by beam nuclei in the collision zone. Production costs for anti-matter are projected for various energy source options and technology levels. Dedicated facilities using heavy ion collisions could produce antiproton at substantially less than 1 million $/milligram. With co-production of other valuable products, e.g., nuclear fuel for power reactors, antiproton costs could be reduced to even lower values

  9. A low-energy antiproton detector prototype for AFIS

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Lingxin; Greenwald, Daniel; Hahn, Alexander; Hauptmann, Philipp; Konorov, Igor; Losekamm, Martin; Paul, Stephan; Poeschl, Thomas; Renker, Dieter [Technische Universitaet Muenchen (Germany)

    2014-07-01

    Antiprotons are produced in interactions of primary cosmic rays with earth's exosphere, where a fraction of them will be confined in the geomagnetic field in the inner van Allen Belt. The antiproton-to-proton flux ratio predicted by theory is in good agreement with recent results from the South Atlantic Anomaly (SAA) published by the PAMELA collaboration. We have designed the AFIS (Antiproton Flux in Space) project in order to extend the measurable range of antiprotons towards the low-energy region. In scope of this project a small antiproton detector consisting of scintillating fibers and silicon photomultipliers is being developed as payload for a CubeSat traversing the SAA in Low Earth Orbit. For the proof of concept we have built a prototype called ''CubeZero'' which completed its first test using pion and proton beams at PSI, Switzerland. Our primary goal was to investigate on the performance of tracking and Bragg peak identification in hardware and software. Analysis of detector performance based on data taken during this beam test is presented in this talk.

  10. Laser spectroscopy of antiprotonic helium and pionic helium

    International Nuclear Information System (INIS)

    ASACUSA (Atomic Spectroscopy and Collisions Using Slow Antiproton) experiment of CERN has observed two-photon spectroscopy by making non-linear transitions of the antiprotons which have occupied highly excited levels. The metastable antiproton helium atoms are studied by irradiating two laser light photons propagating in the counter direction. As the result, the spectrum of narrow line width was observed by making the Doppler width of the resonant transition to decrease. And the anti-proton helium transition frequency was measured with the accuracy of (2.3∼5) X10-9. The mass ratio of the antiproton and the electron has been decided to be Mp/me =1836.152674(23) from the comparison of quantum electrodynamics calculation and the present experimental result. The pion-Helium experiment instrument has been also constructed at the ring cyclotron of PSI (Paul Sherer Institute) toward the successful laser spectroscopy of this atom. When this atom is observed, the π- mass can be obtained with the accuracy higher than 6∼8 orders of magnitude which may contribute to the direct measurement of the upper limit value of muon neutrino mass in the Particle Data Book Mass although various difficulties may be encountered. This report describes briefly the laser spectroscopy at first and then the recent situation of the experiments. (S. Funahashi)

  11. Atomic Spectroscopy and Collisions Using Slow Antiprotons \\\\ ASACUSA Collaboration

    CERN Multimedia

    Matsuda, Y; Lodi-rizzini, E; Kuroda, N; Schettino, G; Hori, M; Soter, A; Pirkl, W; Mascagna, V; Malbrunot, C L S; Yamazaki, Y; Eades, J; Simon, M; Massiczek, O; Sauerzopf, C; Breuker, H; Nagata, Y; Uggerhoj, U I; Mc cullough, R W; Toekesi, K M; Venturelli, L; Widmann, E; Zmeskal, J; Kanai, Y; Hayano, R; Knudsen, H; Kristiansen, H; Todoroki, K; Bartel, M A; Moller, S P; Charlton, M; Leali, M; Diermaier, M; Kolbinger, B

    2002-01-01

    ASACUSA (\\underline{A}tomic \\underline{S}pectroscopy \\underline{A}nd \\underline{C}ollisions \\underline{U}sing \\underline{S}low \\underline{A}ntiprotons) is a collaboration between a number of Japanese and European research institutions, with the goal of studying bound and continuum states of antiprotons with simple atoms.\\\\ Three phases of experimentation are planned for ASACUSA. In the first phase, we use the direct $\\overline{p}$ beam from AD at 5.3 MeV and concentrate on the laser and microwave spectroscopy of the metastable antiprotonic helium atom, $\\overline{p}$He$^+$, consisting of an electron and antiproton bound by the Coulomb force to the helium nucleus. Samples of these are readily created by bringing AD antiproton beam bunches to rest in helium gas. With the help of techniques developed at LEAR for resonating high precision laser beams with antiproton transitions in these atoms, ASACUSA achieved several of these first-phase objectives during a few short months of AD operation in 2000. Six atomic tr...

  12. The Floor's the Limit (Antiproton energies to hit new low)

    CERN Multimedia

    2000-01-01

    Celebrating the success of the RFQ in Aarhus. Left to right: Alessanda Lombardi (CERN), Iouri Bylinskii (CERN), Alex Csete (Aarhus), Ulrik Uggerhøj (Aarhus), Ryu Hayano (Tokyo, spokesman ASACUSA), Helge Knudsen (Aarhus), Werner Pirkl (CERN), Ryan Thompson (Aarhus), Søren P. Møller (Aarhus). Although in particle physics we are accustomed to strive for higher and higher energies, this is not always the most interesting thing to do with antiprotons. Indeed, as recent issues of the Bulletin have suggested, the signpost on the road to a closer look at the antiproton points towards ever-lower energies. The CERN Antiproton Decelerator decelerates antipro-tons emerging from a target placed in the path of a 26 GeV/c proton beam from 90 % of to about 10 % of the speed of light. However, even this is far too fast for many of the most interesting experiments on antiprotons planned by Danish and Japanese members of the ASACUSA collaboration. Tokyo University has therefore financed the con...

  13. Radiotherapy; Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Wannenmacher, M. [Heidelberg Univ., Mannheim (Germany). Abt. fuer Klinische Radiologie; Debus, J. [Univ. Heidelberg (Germany). Abt. Radioonkologie und Strahlentherapie; Wenz, F. (eds.) [Universitaetsklinikum Mannheim (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2006-07-01

    The book is focussed on the actual knowledge on the clinical radiotherapy and radio-oncology. Besides fundamental and general contributions specific organ systems are treated in detail. The book contains the following contributions: Basic principles, radiobiological fundamentals, physical background, radiation pathology, basics and technique of brachytherapy, methodology and technique of the stereotactic radiosurgery, whole-body irradiation, operative radiotherapy, hadron therapy, hpyerthermia, combined radio-chemo-therapy, biometric clinical studies, intensity modulated radiotherapy, side effects, oncological diagnostics; central nervous system and sense organs, head-neck carcinomas, breast cancer, thorax organs, esophagus carcinoma, stomach carcinoma, pancreas carcinoma, heptabiliary cancer and liver metastases, rectal carcinomas, kidney and urinary tract, prostate carcinoma, testicular carcinoma, female pelvis, lymphatic system carcinomas, soft tissue carcinoma, skin cancer, bone metastases, pediatric tumors, nonmalignant diseases, emergency in radio-oncology, supporting therapy, palliative therapy.

  14. From LEAR to HESR: past, present and future of meson spectroscopy with antiprotons

    International Nuclear Information System (INIS)

    Meson spectroscopy experiments performed using antiproton beams have carried out a deep and systematic study of all the main open problems of strong interaction in the non-perturbative regime. In this review, I will sketch the major achievements obtained by experiments studying antiproton annihilations at the CERN LEAR machine and at the Fermilab antiproton accumulator. Finally I will illustrate which topics might be addressed, in the next future, by the new antiproton machine (HESR) that will be available at GSI

  15. Ultra-low energy antiprotons for anti hydrogen spectroscopy and antimatter gravity

    International Nuclear Information System (INIS)

    Approximately one million antiprotons have been captured in a large scale Penning trap at the Low Antiproton Ring (LEAR) at CERN. This has opened new discussions of the possible use of ultra-low energy antiprotons for gravitational physics as well as for precision spectroscopy of anti hydrogen for CPT tests

  16. Many Facets of Strangeness Nuclear Physics with Stored Antiprotons

    CERN Document Server

    Pochodzalla, Josef; Lorente, Alicia Sanchez; Rojo, Marta Martinez; Steinen, Marcell; Gerl, Jürgen; Kojouharova, Jasmina; Kojouharova, Ivan

    2016-01-01

    Stored antiprotons beams in the GeV range represent a unparalleled factory for hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of strange hadronic systems with unprecedented precision. The behavior of hyperons and -- for the first time -- of antihyperons in nuclear systems can be studied under well controlled conditions. The exclusive production of $\\Lambda\\bar{\\Lambda}$ and $\\Sigma^-\\bar{\\Lambda}$ pairs in antiproton-nucleus interactions probe the neutron and proton distribution in the nuclear periphery and will help to sample the neutron skin. For the first time, high resolution $\\gamma$-spectroscopy of doubly strange nuclei will be performed, thus complementing measurements of ground state decays of double hypernuclei with mesons beams at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange $\\Xi$-atoms are feasible and even the pr...

  17. Status of antiproton accumulation and cooling at Fermilab's Recycler

    International Nuclear Information System (INIS)

    The Recycler ring is an 8 GeV permanent magnet storage ring where antiprotons are accumulated and prepared for Fermilab's Tevatron Collider program. With the goal of maximizing the integrated luminosity delivered to the experiments, storing, cooling and extracting antiprotons with high efficiency has been pursued. Over the past two years, while the average accumulation rate doubled, the Recycler continued to operate at a constant level of performance thanks to changes made to the Recycler Electron Cooler (energy stability and regulation, electron beam optics), RF manipulations and operating procedures. In particular, we discuss the current accumulation cycle in which ∼ 400 x 1010 antiprotons are accumulated and extracted to the Tevatron every ∼15 hours

  18. Strangeness production and hypernucleus formation in antiproton induced reactions

    CERN Document Server

    Feng, Zhao-Qing

    2015-01-01

    Formation mechanism of fragments with strangeness in collisions of antiprotons on nuclei has been investigated within the Lanzhou quantum molecular dynamics (LQMD) transport approach combined with a statistical model (GEMINI) for describing the decays of excited fragments. Production of strange particles in the antiproton induced nuclear reactions is modeled within the LQMD model, in which all possible reaction channels such as elastic scattering, annihilation, charge exchange and inelastic scattering in antibaryon-baryon, baryon-baryon and meson-baryon collisions have been included. A coalescence approach is developed for constructing hyperfragments in phase space after de-excitation of nucleonic fragments. The combined approach could describe the production of fragments in low-energy antiproton induced reactions. Hyperfragments are formed within the narrower rapidities and lower kinetic energies. It has advantage to produce heavier hyperfragments and hypernuclides with strangeness s=-2 (double-$\\Lambda$ fra...

  19. Antiproton-Nucleus Interaction and Coulomb Effect at High Energies

    Institute of Scientific and Technical Information of China (English)

    ZHOU Li-Juan; WU Qing; GU Yun-Ting; MA Wei-Xing; TAN Zhen-Qiang; HU Zhao-Hui

    2005-01-01

    The Coulomb effect in high energy antiproton-nucleus elastic and inelastic scattering from 12C and 16O is studied in the framework of Glauber multiple scattering theory for five kinetic energies ranged from 0.23 to 1.83 GeV.A microscopic shell-model nuclear wave functions, Woods-Saxon single-particle wave functions, and experimental pN amplitudes are used in the calculations. The results show that the Coulomb effect is of paramount importance for filling up the dips of differential cross sections. We claim that the present result for inelastic scattering of antiproton-12C is sufficiently reliable to be a guide for measurements in the very near future. We also believe that antiproton nucleus elastic and inelastic scattering may produce new information on both the nuclear structure and the antinucleon-nucleon interaction, in particular the p-neutron interaction.

  20. Energy and energy width measurement in the FNAL antiproton accumulator

    Energy Technology Data Exchange (ETDEWEB)

    Church, M.; Hsueh, S.; Rapidis, P.; Werkema, S.

    1991-10-01

    The Fermilab Antiproton Accumulator has recently been used to produce Charmonium resonances (charm quark, anti-charm quark bound states) in proton-antiproton annihilations using an internal H{sub 2} gas jet target. A measurement of the resonance mass and width may be obtained from a precise knowledge of the antiproton beam energy and energy spread. The beam energy is measured to an accuracy of 1 part in 10{sup 4} in the range 6.3 Gev to 4.1 Gev by measuring the orbit length and revolution frequency of the beam. The beam momentum spread is measured to an accuracy of 10% by measuring the beam frequency spread and the parameter {eta} = (P{sub beam}/F{sub rev}){center dot}(dF{sub rev}/dP{sub beam}). These two measurement techniques are described in this report.

  1. Antiproton-induced fission for space power and propulsion applications

    International Nuclear Information System (INIS)

    The Gasdynamic Mirror[GDM] fusion reactor is investigated for use as a bi-modal propulsion device when driven by antiprotons.The deuterium-tritium[DT] fusion reactions in the device will be initiated by the heating provided by the fission fragments and annihilation products resulting from the 'at rest' annihilation of antiprotons in U-238 target nuclei.The energetic pions and muons of the proton-antiproton[or neutron]annihilation in the U-238 nucleus can heat a DT plasma to several keV during their relatively short lifetimes.The remaining heating to about 10 keV is provided by the fission fragments.Fissioning of U-238 by 'at rest' annihilation of antiprotons has been shown to be 100% efficient,and the process can thus be effectively used in heating a suitable plasma to thermonuclear temperatures.With GDM as a steady state fusion reactor,and assuming certain efficiencies for the various components of the system,we calculate the energy multiplication factor 'Q' needed to sustain the steady-state operation for either the 'propulsive' mode or the 'power-producing' mode.With the aid of a system and mission analyses,we find that approximately 3.5 micrograms of antiprotons are required to accomplish a round mission to Mars in about 59 days.A similar amount is required to initiate and sustain the power-producing mode where gigawatts of electric power may be generated.Although roughly nanograms of antiprotons are currently produced annually,it is expected that hundreds of milligrams or even several grams will be produced annually in the next decade or so when Mars missions may be contemplated

  2. High-energy antiprotons from old supernova remnants

    CERN Document Server

    Blasi, Pasquale

    2009-01-01

    A recently proposed model (arXiv:0903.2794) explains the rise in energy of the positron fraction measured by the PAMELA satellite in terms of hadronic production of positrons in aged supernova remnants, and acceleration therein. Here we present a preliminary calculation of the anti-proton flux produced by the same mechanism. While the model is consistent with present data, a rise of the antiproton to proton ratio is predicted at high energy, which strikingly distinguishes this scenario from other astrophysical explanations of the positron fraction (like pulsars). We briefly discuss important implications for Dark Matter searches via antimatter.

  3. Transverse instability of the antiproton beam in the Recycler Ring

    CERN Document Server

    Prost, L R; Burov, A; Crisp, J; Eddy, N; Hu, M; Shemyakin, A

    2012-01-01

    The brightness of the antiproton beam in Fermilab's 8 GeV Recycler ring is limited by a transverse instability. This instability has occurred during the extraction process to the Tevatron for large stacks of antiprotons even with dampers in operation. This paper describes observed features of the instability, introduces the threshold phase density to characterize the beam stability, and finds the results to be in agreement with a resistive wall instability model. Effective exclusion of the longitudinal tails from Landau damping by decreasing the depth of the RF potential well is observed to lower the threshold density by up to a factor of two.

  4. Transverse instability of the antiproton beam in the Recycler Ring

    Energy Technology Data Exchange (ETDEWEB)

    Prost, L.R.; Bhat, C.M.; Burov, A.; Crisp, J.; Eddy, N.; Hu, M.; Shemyakin, A.; /Fermilab

    2011-03-01

    The brightness of the antiproton beam in Fermilab's 8 GeV Recycler ring is limited by a transverse instability. This instability has occurred during the extraction process to the Tevatron for large stacks of antiprotons even with dampers in operation. This paper describes observed features of the instability, introduces the threshold phase density to characterize the beam stability, and finds the results to be in agreement with a resistive wall instability model. Effective exclusion of the longitudinal tails from Landau damping by decreasing the depth of the RF potential well is observed to lower the threshold density by up to a factor of two.

  5. Prospects of CPT tests using antiprotonic helium and antihydrogen

    International Nuclear Information System (INIS)

    Testing CPT to the highest possible precision using the laser spectroscopy of antiprotonic helium atoms (a neutral three-body system consisting of an antiproton, a helium nucleus and an electron) is the current goal of ASACUSA collaboration at CERN AD. The present status and future prospects are discussed in the first half of the talk. Our program will be extended in the future to include the microwave spectroscopy of ground-state hyperfine splitting of antihydrogen. The physics motivations and possible measurement schemes are presented in the second half

  6. Relativistic hydrodynamics, heavy ion reactions and antiproton annihilation

    International Nuclear Information System (INIS)

    The application of relativistic hydrodynamics to relativistic heavy ions and antiproton annihilation is summarized. Conditions for validity of hydrodynamics are presented. Theoretical results for inclusive particle spectra, pion production and flow analysis are given for medium energy heavy ions. The two-fluid model is introduced and results presented for reactions from 800 MeV per nucleon to 15 GeV on 15 GeV per nucleon. Temperatures and densities attained in antiproton annihilation are given. Finally, signals which might indicate the presence of a quark-gluon plasma are briefly surveyed

  7. Measurement of cosmic-ray antiproton spectrum at solar minimum with a long-duration balloon flight in Antarctica

    CERN Document Server

    Abe, K; Haino, S; Hams, T; Hasegawa, M; Horikoshi, A; Kim, K C; Kusumoto, A; Lee, M H; Makida, Y; Matsuda, S; Matsukawa, Y; Mitchell, J W; Nishimura, J; Nozaki, M; Orito, R; Ormes, J F; Sakai, K; Sasaki, M; Seo, E S; Shinoda, R; Streitmatter, R E; Suzuki, J; Tanaka, K; Thakur, N; Yamagami, T; Yamamoto, A; Yoshida, T; Yoshimura, K

    2011-01-01

    The energy spectrum of cosmic-ray antiprotons has been measured in the range 0.17 to 3.5 GeV, based on 7886 antiprotons collected by the BESS-Polar II instrument during a long-duration flight over Antarctica in the solar minimum period of December 2007 through January 2008. The antiproton spectrum measured by BESS-Polar II shows good consistency with secondary antiproton calculations. Cosmologically primary antiprotons have been searched for by comparing the observed and calculated antiproton spectra. The BESS-Polar II result shows no evidence of primary antiprotons originating from the evaporation of PBH.

  8. Beam Diagnostics for Measurements of Antiproton Annihilation Cross Sections at Ultra-low Energy

    Directory of Open Access Journals (Sweden)

    Todoroki K.

    2014-03-01

    Full Text Available The ASACUSA (Atomic Spectroscopy And Collisions Using Slow Antiprotons collaboration of CERN is currently attempting to measure the antiproton-nucleus in-flight annihilation cross sections on thin target foils of C, Pd, and Pt at 130 keV of kinetic energy. The low-energy antiprotons were supplied by the Antiproton Decelerator (AD and a radio-frequency quadrupole decelerator. For this measurement, a beam profile monitor based on secondary electron emission was developed. Data from this monitor was used to ensure that antiprotons were precisely tuned to the position of an 80-mm-diameter experimental target, by measuring the spatial profile of 200-ns-long beam pulses containing 105 − 106 antiprotons with an active area of 40 mm × 40 mm and a spatial resolution of 4 mm. By using this monitor, we succeeded in finely tuning antiproton beams on the target, and observed some annihilation events originating from the target.

  9. Secondary antiprotons as a Galactic Dark Matter probe

    CERN Document Server

    Evoli, Carmelo; Grasso, Dario

    2015-01-01

    We present a novel determination of the astrophysical uncertainties associated to the secondary antiproton flux originating from cosmic-ray spallation on the interstellar gas. We select a set of propagation models compatible with the recent B/C data from PAMELA, and find those providing minimal and maximal antiproton fluxes in different energy ranges. We use this result to determine the most conservative bounds on relevant Dark Matter (DM) annihilation channels: We find that the recent claim of a DM interpretation of a gamma-ray excess in the Galactic Center region cannot be ruled out by current antiproton data. Finally, we discuss the impact of the recently released preliminary data from AMS-02. In particular, we provide a reference model compatible with proton, helium and B/C spectra from this experiment. Remarkably, the main propagation parameters of this model are in perfect agreement with the best fit presented in our earlier statistical analyses. We also show that the antiproton-to-proton ratio does not...

  10. Enhancing trappable antiproton populations through deceleration and frictional cooling

    Energy Technology Data Exchange (ETDEWEB)

    Zolotorev, Max; Sessler, Andrew; Penn, Gregory; Wurtele, Jonathan S.; Charman, Andrew E.

    2012-03-20

    CERN currently delivers antiprotons for trapping experiments with the Antiproton Decelerator (AD), which slows the antiprotons down to about 5 MeV.This energy is currently too high for direct trapping, and thick foils are used to slow down the beam to energies which can be trapped.To allow further deceleration to $\\sim 100 \\;\\mbox{keV}$, CERN is initiating the construction of ELENA,consisting of a ring which will combine RF deceleration and electron cooling capabilities. We describe a simple frictionalcooling scheme that can serve to provide significantly improved trapping efficiency, either directly from the AD or first usinga standard deceleration mechanism (induction linac or RFQ). This scheme could be implemented in a short time.The device itself is short in length, uses accessible voltages, and at reasonable cost could serve in the interim beforeELENA becomes operational, or possibly in lieu of ELENA for some experiments. Simple theory and simulations provide a preliminary assessment of theconcept and its strengths and limitations, and highlight important areas for experimental studies, in particular to pin down the level of multiplescattering for low-energy antiprotons. We show that the frictional cooling scheme can provide a similar energy spectrum to that of ELENA,but with higher transverse emittances.

  11. An Advanced Hadron Facility: Prospects and applicability to antiproton production

    International Nuclear Information System (INIS)

    An Advanced Hadron Facility is designed to address physics problems within and beyond the Standard Model. High fluxes of secondary beams are needed for the requisite precision tests and searches for very rare decay modes of mesons and baryons. Such high fluxes at useful secondary energies are readily obtained from high intensity, intermediate energy proton beams, which are also well suited to antiproton production. If the AHF primary proton beam were merely dumped into a beam stop, it would produce on the order of 1019 to 1020 antiprotons per operating year. Current collection techniques are not likely to be capable of absorbing more than one part in 103 of this production. Thus, an AHF provides both the immediate possibility of collecting quantities of antiprotons substantially beyond those available from the LEF discussed at this meeting, and for significant increases in the available antiproton supply upon the development (at an AHF) of more efficient collection methods. The prospects are presently good for the completion of an AHF in the late 1990's

  12. ACOL, CERN'S upgrade of the antiproton accelerator complex

    International Nuclear Information System (INIS)

    At its present best the Antiproton Accumulator (AA) produces 6 x 10/sup 9/ p-bar's/hour. In routine operation this amounts to around 10/sup 11/ p-bar's/day including anadvertent stops of all the systems involved. Post ACOL performance aims at increasing these rates tenfold

  13. Outer casing of the AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling.

  14. Delta-Isobar Production in Antiproton Annihilation on the Deuteron

    OpenAIRE

    Lykasov, G. I.; Bussa, M. P.; Valacca, L.

    1997-01-01

    The annihilation of antiprotons on deuterons at rest are investigated for the case when pion-nucleon and pion-delta-isobar pairs are produced. The two-step mechanism is investigated by analysing these processes when either neutral particles and charged ones are produced. Some predictions for the branching ratios are presented.

  15. Palliative Radiotherapy

    International Nuclear Information System (INIS)

    Palliative care does not attempt to prolong survival but to the achieve the highest quality of life both for the patient and their family covering their physical, psychological, social and spiritual needs. Radiotherapy (RT), one of the most important therapeutic modalities, has a great significance in palliative medicine for cancer since it attempts to reduce as much as possible the acute reaction associated with the treatment for the patient. (Author)

  16. Constraints on particle dark matter from cosmic-ray antiprotons

    International Nuclear Information System (INIS)

    Cosmic-ray antiprotons represent an important channel for dark matter indirect-detection studies. Current measurements of the antiproton flux at the top of the atmosphere and theoretical determinations of the secondary antiproton production in the Galaxy are in good agreement, with no manifest deviation which could point to an exotic contribution in this channel. Therefore, antiprotons can be used as a powerful tool for constraining particle dark matter properties. By using the spectrum of PAMELA data from 50 MV to 180 GV in rigidity, we derive bounds on the dark matter annihilation cross section (or decay rate, for decaying dark matter) for the whole spectrum of dark matter annihilation (decay) channels and under different hypotheses of cosmic-rays transport in the Galaxy and in the heliosphere. For typical models of galactic propagation, the constraints are strong, setting a lower bound on the dark matter mass of a ''thermal'' relic at about 40–80 GeV for hadronic annihilation channels. These bounds are enhanced to about 150 GeV on the dark matter mass, when large cosmic-rays confinement volumes in the Galaxy are considered, and are reduced to 3–4 GeV for annihilation to light quarks (no bound for heavy-quark production) when the confinement volume is small. Bounds for dark matter lighter than few tens of GeV are due to the low energy part of the PAMELA spectrum, an energy region where solar modulation is relevant: to this aim, we have implemented a detailed solution of the transport equation in the heliosphere, which allowed us not only to extend bounds to light dark matter, but also to determine the uncertainty on the constraints arising from solar modulation modelling. Finally, we estimate the impact of soon-to-come AMS-02 data on the antiproton constraints

  17. Measurement of the antiproton magnetic moment and a determination of the LS-term for the antiproton-nucleus-interaction

    International Nuclear Information System (INIS)

    The subjects of this thesis are a measurement of the antiproton magnetic moment, a particle property, with the aim of testing the CPT-theorem for the strong interaction and the investigation of a possible spin-orbit-term of the anti p-nucleus-interaction. For both aspects the information is given in the finestructure-splitting of antiprotonic X-ray-transitions from heavy nuclei, since only for those the splitting is observable. From the finestructure-splitting of the transition 11→10 in 208Pb the magnetic moment of the antiproton can be calculated. The result of this best measurement up to now is μ sub anti p = (-2.8007±0.0091)μN. In between the error bars it confirms the CPT-Theorem and the new average value for the difference of the antiproton magnetic moment from the proton magnetic moment is (μp-anti μ sub anti p)/average = (-2.5±3).10-3. At the same time the limits of our detectors are described and other possibilities are discussed. In 174Yb one observes a splitting of the last observable transition 9→8, which is influenced by the strong interaction. From our measurement we find that the measured splitting is different from the calculated electromagnetic value and the Lorentz-widths of both line components are different as well. It is ΔEsw = 58±25±13 eV and ΔΓ = 195±58±20 eV. As result we find a sign for the existence of a spin-orbit-term of the antiproton-nucleus-interaction. Nevertheless is has to be confirmed in further experiments. (orig./HSI)

  18. Postmastectomy radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Shikama, Naoto; Koguchi, Masahiko; Sasaki, Shigeru; Kaneko, Tomoki; Shinoda, Atsunori; Nishikawa, Atsushi [Shinshu Univ., Matsumoto, Nagano (Japan). School of Medicine

    2000-10-01

    Since there have been few reports on postmastectomy radiotherapy having a high evidence level in Japan, the significance of postoperative radiotherapy and the irradiation techniques were reviewed based on reports from Western countries. Authors focused on the indications for postoperative irradiation, irradiation methods (irradiation sites, irradiation techniques; prosthetics, methods of irradiating the chest wall and lymph nodes, timing of irradiation), and complications, and discuss them. The factors thought to be adaptable to postmastectomy radiotherapy have been listed. Axillary lymph node metastasis and the size of the primary focus are thought to be important factors in locoregional recurrence. The chest wall and the supraclavicular lymph nodes are the usual sites of irradiation after mastectomy. The irradiation method consists of tangential irradiation of the chest wall and single-field irradiation of the supraclavicular lymph nodes, with 46-50 Gy in fractional doses of 1.8-2 Gy x 5/w is administered for 4.5-5.5 weeks. The timing of irradiation in the West is generally after chemotherapy. Adverse radiation effects include ischemic heart disease, pneumonitis, arm edema, rib fractures, and brachial plexus paralysis. The frequency of these complications is increased by the combined use of chemotherapy or surgery. The breast cancer cure rate in Japan is generally better than in the West. It remains to be determined whether the clinical data from Europe and America are applicable to the treatment of breast cancer in Japan. To address this issue, a clinical investigation should be performed in Japan with close cooperation between surgeons, physicians, pathologists, and radiotherapists. (K.H.)

  19. Intraoperative radiotherapy

    International Nuclear Information System (INIS)

    The potential benefit of intraoperative radiotherapy (IORT) was originally recognized years ago and has recently attracted renewed interest. Modern radiotherapeutic approaches may be more successful as a result of technical innovation, particularly in the use of electron beam accelerators. Preliminary studies, mainly uncontrolled and nonrandomized, have assessed the role of IORT for treatment of a variety of deep seated abdominal, retroperitoneal, and pelvic cancers. The results of some studies show much promise, but prospective trials are needed to scientifically validate these favorable initial observations. (Auth.)

  20. Laser spectroscopy of the antiprotonic helium atom – its energy levels and state lifetimes

    CERN Document Server

    Hidetoshi, Yamaguchi

    2003-01-01

    The antiprotonic atom is a three-body exotic system consisting of an antiproton, an electron and a helium nucleus. Its surprising longevity was found and has been studied for more than 10 years. In this work, transition energies and lifetimes of this exotic atom were systematically studied by using the antiproton beam of AD(Antiproton Decelerator) facility at CERN, with an RFQ antiproton decelerator, a narrow-bandwidth laser, Cerenkov counters with fast-response photomultiplier tubes, and cryogenic helium target systems. Thirteen transition energies were determined with precisions of better than 200 ppb by a laser spectroscopy method, together with the elimination of the shift effect caused by collisions with surrounding atoms. Fifteen lifetimes (decay rates) of short-lived states were determined from the time distributions of the antiproton-annihilation signals and the resonance widths of the atomic spectral lines. The relation between the magnitude of the decay rates and the transition multipolarity was inv...

  1. Radiotherapy of adult nodal non Hodgkin's lymphoma

    International Nuclear Information System (INIS)

    The role of radiotherapy in the treatment of nodal non-Hodgkin's lymphoma has been modified by the introduction of efficient chemotherapy and the development of different pathological classifications. The recommended treatment of early-stage aggressive lymphomas is primarily a combination chemotherapy. The interest of adjuvant radiotherapy remains unclear and has to be established through large prospective trials. If radiation therapy has to be delivered, the historical results of exclusive radiation therapy showed that involved-fields and a dose of 35-40 Gy (daily fraction of 1.8 Gy, 5 days a week) are the optimal schedule. The interest of radiotherapy in the treatment of advanced-stage aggressive lymphoma is yet to be proven. Further studies had to stratify localized stages according to the factors of the International Prognostic Index. For easy-stage low-grade lymphoma, radiotherapy remains the standard treatment. However, the appropriate technique to use is controversial. Involved-field irradiation at a dose of 35 Gy seems to be the optimal schedule, providing a 10 year disease-free survival rate of 50 % and no major toxicity. There is no standard indication of radiotherapy in the treatment advanced-stage low-grade lymphoma. For 'new' nodal lymphoma's types, the indication of radiotherapy cannot be established (mantle-zone lymphoma, marginal zone B-cell lymphoma) or must take into account the natural history (Burkitt's lymphoma, peripheral T-cell lymphoma) and the sensibility to others therapeutic methods. (authors)

  2. TH-C-12A-02: Comparison of Two RapidArc Delivery Strategies in Stereotactic Body Radiotherapy of Stage I and II Peripheral Lung Tumors with Unflattened Beams

    International Nuclear Information System (INIS)

    Purpose: The full arcs strategy used in SBRT with RapidArc and unflattened (FFF) beams in large and heterogeneous peripheral non-smallcell lung cancer (NSCLC) appears to be suboptimal as it increases the disadvantageous dose to the contralateral lung, which potentially increases the toxicity to surrounding tissues. In this study, we investigated, for the first time, the dose delivery strategies using partial arcs (PA) and the fully rotational arcs with avoidance sectors (FAAS) for SBRT with FFF beams in peripheral NSCLC patients. Methods: Eighteen patients with NSCLC (stage I and II) were selected for this study. Nine patients with a GTV <= 10cc were designated as the small tumor group. The remaining nine patients with a GTV between 10 cc and 44 cc were assigned to the large tumor group. The treatment plans were generated in eighteen patients using PA and FAAS, respectively, and delivered with a Varian TrueBeam Linac. Dosimetry of the target and organs at risk (OAR), total MU, out-of-field dose, and delivery time were analyzed. Delta4 and Portal dosimetry were employed to evaluate the delivery accuracy. Results: or the small tumor group, the FAAS plans significantly achieved a better conformity index, the lower total MU and out-of-field dose, a shorter treatment time, and the reduced doses to cord, heart, and lung (p < 0.05). But the target doses were slightly higher than that delivered by PA plans. For the large tumor group, the PA plans significantly attained a better conformity index and a shorter treatment time (p < 0.05). Furthermore, all plans achieved a high pass rate, with all the gamma indices greater than 97% at the Γ3mm, 3% threshold. Conclusion: This study suggests that FAAS strategy is more beneficial for small tumor patients undergoing lung SBRT with FFF beams. However, for large tumor patients, PA strategy is recommended. NIH/NIGMS grant U54 GM104944, Lincy Endowed Assistant Professorship

  3. Preparations for HFS spectroscopy of antiprotonic 3He

    International Nuclear Information System (INIS)

    Full text: Antiprotonic helium (pHe) is a neutral exotic atom, consisting of a helium nucleus, an electron and an antiproton. The interactions of the angular momenta and spins of its constituents cause splitting within the principle states. The measured transition frequencies between hyperfine levels can be compared with three-body QED calculations as a test of the theory. Previous measurements have been performed on p4He. The next two years will be dedicated to measuring a similar transition within p3He. Due to the additional coupling to the helion spin, it consists of an octuplet of states instead of a quadruplet. A new microwave cavity has been designed and is being constructed for the transition frequency of 11.14 GHz. This cavity has been simulated using the high frequency structure simulator HFSS to obtain the correct cavity dimensions. A new cryostat to cool the target is under construction. Numerical simulations are also in progress. (author)

  4. Testing quantum chromodynamics in anti-proton reactions

    Energy Technology Data Exchange (ETDEWEB)

    Brodsky, S.J.

    1987-10-01

    An experimental program with anti-protons at intermediate energy can serve as an important testing ground for QCD. Detailed predictions for exclusive cross sections at large momentum transfer based on perturbative QCD and the QCD sum rule form of the proton distribution amplitude are available for anti p p ..-->.. ..gamma gamma.. for both real and virtual photons. Meson-pair and lepton-pair final states also give sensitive tests of the theory. The production of charmed hadrons in exclusive anti p p channels may have a non-negligible cross section. Anti-proton interactions in a nucleus, particularly J/psi production, can play an important role in clarifying fundamental QCD issues, such as color transparency, critical length phenomena, and the validity of the reduced nuclear amplitude phenomenology.

  5. Dark matter for excess of AMS-02 positrons and antiprotons

    Directory of Open Access Journals (Sweden)

    Chuan-Hung Chen

    2015-07-01

    Full Text Available We propose a dark matter explanation to simultaneously account for the excess of antiproton-to-proton and positron power spectra observed in the AMS-02 experiment while having the right dark matter relic abundance and satisfying the current direct search bounds. We extend the Higgs triplet model with a hidden gauge symmetry of SU(2X that is broken to Z3 by a quadruplet scalar field, rendering the associated gauge bosons stable weakly-interacting massive particle dark matter candidates. By coupling the complex Higgs triplet and the SU(2X quadruplet, the dark matter candidates can annihilate into triplet Higgs bosons each of which in turn decays into lepton or gauge boson final states. Such a mechanism gives rise to correct excess of positrons and antiprotons with an appropriate choice of the triplet vacuum expectation value. Besides, the model provides a link between neutrino mass and dark matter phenomenology.

  6. A Good Statistics Study of Antiproton Interactions with Nuclei

    CERN Multimedia

    2002-01-01

    This experiment extends the study of inclusive pion production and the correlation between pions which result from hadron-nucleus collisions at intermediate and high energies to the antiproton-nucleus system. It is part of a long term systematic search for exotic nuclear phenomena. The correlation data will be used to extract, via pion interferometry, the size and coherence of the annihilation source in nuclei. In addition, the reaction @* + A @A p + A* will be studied to look for structure in the proton spectra which antiproton-nucleus bound states.\\\\ \\\\ The experimental system is based on a flexible, broad range, large acceptance (1~steradian) spectrometer which consists of an 80~cm diameter dipole magnet surrounded with detector arrays. These detectors provide momentum, energy loss, Cerenkov and time of flight information for up to ten ejectiles per event. Momentum resolution varies from 1\\% to 3\\%, depending on energy.

  7. Proton-antiproton annihilation into two photons at large s

    CERN Document Server

    Weiss, C

    2002-01-01

    Exclusive proton-antiproton annihilation into two photons can be viewed as the Compton process in the crossed channel. At large s (~10 GeV^2) and |t|,|u| s this process can be described by a generalized partonic picture, analogous to the 'soft mechanism' in wide-angle real Compton scattering. The two photons are emitted in the annihilation of a single fast quark and antiquark ('handbag graph'). The transition of the p-pbar system to a q-qbar pair through soft interactions is described by double distributions, which can be related to the timelike proton elastic form factors as well as, by crossing symmetry, to the usual quark--antiquark distributions in the nucleon. We estimate that this reaction should be observable with reasonable statistics at the proposed 1.5..15 GeV high-luminosity antiproton storage ring (HESR) at GSI.

  8. Testing quantum chromodynamics in anti-proton reactions

    International Nuclear Information System (INIS)

    An experimental program with anti-protons at intermediate energy can serve as an important testing ground for QCD. Detailed predictions for exclusive cross sections at large momentum transfer based on perturbative QCD and the QCD sum rule form of the proton distribution amplitude are available for anti p p → γγ for both real and virtual photons. Meson-pair and lepton-pair final states also give sensitive tests of the theory. The production of charmed hadrons in exclusive anti p p channels may have a non-negligible cross section. Anti-proton interactions in a nucleus, particularly J/psi production, can play an important role in clarifying fundamental QCD issues, such as color transparency, critical length phenomena, and the validity of the reduced nuclear amplitude phenomenology

  9. Bubble detector measurements of a mixed radiation field from antiproton annihilation

    DEFF Research Database (Denmark)

    Bassler, Niels; Knudsen, Helge; Møller, Søren Pape; Petersen, Jørgen B.B.; Rahbek, Dennis Bo; Uggerhøj, Ulrik Ingerslev

    2006-01-01

    In the light of recent progress in the study of the biological potential of antiproton tumour treatment it is important to be able to characterize the neutron intensity arising from antiproton annihilation using simple, compact and reliable detectors. The intensity of fast neutrons from antiproton...... annihilation on polystyrene has been measured with bubble detectors and a multiplicity has been derived as well as an estimated neutron equivalent dose. Additionally the sensitivity of bubble detectors towards protons was measured....

  10. Bubble detector measurements of a mixed radiation field from antiproton annihilation

    CERN Document Server

    Bassler, Niels; Møller, Søren Pape; Petersen, Jørgen B.; Rahbek, Dennis; Uggerhøj, Ulrik I.

    2006-01-01

    In the light of recent progress in the study of the biological potential of antiproton tumour treatment it is important to be able to characterize the neutron intensity arising from antiproton annihilation using simple, compact and reliable detectors. The intensity of fast neutrons from antiproton annihilation on polystyrene has been measured with bubble detectors and a multiplicity has been derived as well as an estimated neutron equivalent dose. Additionally the sensitivity of bubble detectors towards protons was measured.

  11. Commissioning of Fermilab's Electron Cooling System for 8-GeV Antiprotons

    CERN Document Server

    Nagaitsev, Sergei; Burov, Alexey; Carlson, Kermit; Gai, Wei; Gattuso, Consolato; Hu, Martin; Kazakevich, Grigory; Kramper, Brian J; Kroc, Thomas K; Leibfritz, Jerry; Prost, Lionel; Pruss, Stanley M; Saewert, Greg W; Schmidt, Chuck; Seletsky, Sergey; Shemyakin, Alexander V; Sutherland, Mary; Tupikov, Vitali; Warner, Arden

    2005-01-01

    A 4.3-MeV electron cooling system has been installed at Fermilab in the Recycler antiproton storage ring and is being currently commissioned. The cooling system is designed to assist accumulation of 8.9-GeV/c antiprotons for the Tevatron collider operations. This paper will report on the progress of the electron beam commissioning effort as well as on detailed plans of demonstrating the cooling of antiprotons.

  12. Current status of antiproton impact ionization of atoms and molecules: theoretical and experimental perspectives

    DEFF Research Database (Denmark)

    Kirchner, Tom; Knudsen, Helge

    2011-01-01

    Experimental and theoretical progress in the field of antiproton-impact-induced ionization of atoms and molecules is reviewed. We describe the techniques used to measure ionization cross sections and give an overview of the experimental results supplemented by tables of all existing data. An...... status of our understanding of antiproton impact ionization. The related issues of energy loss measurements and antiproton therapy are briefly described and directions for possible future work are pointed out as well....

  13. Production of ultra slow antiprotons, its application to atomic collisions and atomic spectroscopy - ASACUSA project

    International Nuclear Information System (INIS)

    The Atomic Spectroscopy And Collisions Using Slow Antiprotons (ASACUSA) project aims at studying collision dynamics with slow antiprotons and high precision spectroscopy of antiprotonic atoms. To realize these purposes, the production of high quality ultra slow antiproton beams is essential, which is achieved by the combination of antiproton decelerator (AD) from 3 GeV to 5 MeV, a radio frequency quadrupole (RFQ) decelerator from 5 MeV to 50 keV, and finally an electromagnetic trap from 50 keV to 10 eV. From the atomic physics point of view, an antiproton is an extremely heavy electron and/or a negatively charged proton, i.e., the antiproton is a unique tool to shed light on collision dynamics from the other side of the world. In addition to this fundamentally important feature, the antiproton has also a big practical advantage, i.e., it annihilates with the target nuclei emitting several energetic pions, which provides high detection efficiency with very good time resolution. Many-body effects which are of great importance to several branches of science will be studied through ionization and antiprotonic atom formation processes under single collision conditions. Various antiprotonic atoms including protonium (p anti-p) are expected to be meta-stable in vacuum, which is never true for those in dense media except for antiprotonic helium. High precision spectroscopy of protonium will for the first time become feasible benefited by this meta-stability. The present review reports briefly the production scheme of ultra slow antiproton beams and several topics proposed in the ASACUSA project

  14. Asymmetric antiproton debuncher: No bad mixing, more good mixing

    International Nuclear Information System (INIS)

    An asymmetric lattice for the Fermilab Antiproton Debuncher is designed. The lattice has zero mixing between the pickups and the kickers (bad mixing) while the mixing in the rest of the machine (good mixing) can be varied (even during the operation of the machine) in order to optimize the stochastic cooling. As an example, a lattice with zero bad mixing and twice the good mixing is presented. The betatron cooling rate in this lattice is twice its present value

  15. Heating of nuclear matter and multifragmentation: antiprotons vs. pions

    International Nuclear Information System (INIS)

    Heating of nuclear matter with 8 GeV/c bar p and π- beams has been investigated in an experiment conducted at BNL AGS accelerator. All charged particles from protons to Z ≅ 16 were detected using the Indiana Silicon Sphere 4π array. Significant enhancement of energy deposition in high multiplicity events is observed for antiprotons compared to other hadron beams. The experimental trends are qualitatively consistent with predictions from an intranuclear cascade code

  16. The discovery of geomagnetically trapped cosmic ray antiprotons

    OpenAIRE

    Adriani, O.; Barbarino, G. C.; Bazilevskaya, G. A.; Bellotti, R.; M. Boezio; Bogomolov, E.A.; M. Bongi; Bonvicini, V.; Borisov, S.; Bottai, S.; Bruno, A.; F. Cafagna; Campana, D.; Carbone, R.; Carlson, P.

    2011-01-01

    The existence of a significant flux of antiprotons confined to Earth's magnetosphere has been considered in several theoretical works. These antiparticles are produced in nuclear interactions of energetic cosmic rays with the terrestrial atmosphere and accumulate in the geomagnetic field at altitudes of several hundred kilometers. A contribution from the decay of albedo antineutrons has been hypothesized in analogy to proton production by neutron decay, which constitutes the main source of tr...

  17. Antiprotons from dark matter annihilation in the Galaxy. Astrophysical uncertainties

    Energy Technology Data Exchange (ETDEWEB)

    Evoli, Carmelo [Chinese Academy of Sciences, Beijing (China). National Astronomical Observatories; Cholis, Ilias; Ullio, Piero [SISSA, Sezione di Trieste (Italy); INFN, Sezione di Trieste (Italy); Grasso, Dario [INFN, Sezione di Pisa (Italy); Maccione, Luca [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-08-15

    The latest years have seen steady progresses in WIMP dark matter (DM) searches, with hints of possible signals suggested by both direct and indirect detection experiments. Antiprotons can play a key role validating those interpretations since they are copiously produced by WIMP annihilations in the Galactic halo, and the secondary antiproton background produced by Cosmic Ray (CR) interactions is predicted with fair accuracy and matches the observed spectrum very well. Using the publicly available numerical DRAGON code, we reconsider antiprotons as a tool to constrain DM models discussing its power and limitations. We provide updated constraints on a wide class of annihilating DM models by comparing our predictions against the most up-to-date anti p measurements, taking also into account the latest spectral information on the p, He and other CR nuclei fluxes. Doing that, we probe carefully the uncertainties associated to both secondary and DM originated antiprotons, by using a variety of distinctively different assumptions for the propagation of CRs and for the DM distribution in the Galaxy. We find that the impact of the astrophysical uncertainties on constraining the DM properties can be much stronger, up to a factor of {proportional_to}50, than the one due to uncertainties on the DM distribution ({proportional_to}2-6). Remarkably, even reducing the uncertainties on the propagation parameters derived by local observables, non-local effects can still change DM model constraints even by 50%. Nevertheless, current anti p data place tight constraints on DM models, excluding some of those suggested in connection with indirect and direct searches. Finally we discuss the power of upcoming CR spectral data from the AMS-02 observatory to drastically reduce the uncertainties discussed in this paper and estimate the expected sensitivity of this instrument to some sets of DM models. (orig.)

  18. Physics at the Fermilab Tevatron Proton-Antiproton Collider

    International Nuclear Information System (INIS)

    These lectures discuss a selection of QCD and Electroweak results from the CDF and D0 experiments at the Fermilab Tevatron Proton-Antiproton Collider. Results are presently based on data samples of about 20 pb-1 at a center-of-mass energy of 1.8 TeV. Results discussed include jet production, direct photon production, W mass and width measurements, the triboson coupling, and most exciting of all, evidence for top quark production

  19. Perspectives for low energy antiproton physics at FAIR

    OpenAIRE

    Widmann, Eberhard

    2014-01-01

    The CRYRING accelerator, previously located at the Manne Siegbahn Laboratory of Stockholm University, has been chosen by the FLAIR collaboration as the central accelerator for the planned facility. It has been modified to allow for high-energy injection and extraction and is capable of providing fast and slow extracted beams of antiprotons and highly charged ions. It is currently being installed at the ESR of GSI Darmstadt where it can be used with highly charged ions. The future possibilitie...

  20. Heating of nuclear matter and multifragmentation : antiprotons vs. pions.

    Energy Technology Data Exchange (ETDEWEB)

    Back, B.; Beaulieu, L.; Breuer, H.; Gushue, S.; Hsi, W.-C.; Korteling, R. G.; Kwiatkowski, K.; Laforest, R.; Lefort, T.; Martin, E.; Pienkowski, L.; Ramakrishnan, E.; Remsberg, L. P.; Rowland, D.; Ruangma, A.; Viola, V. E.; Winchester, E.; Yennello, S. J.

    1999-05-03

    Heating of nuclear matter with 8 GeV/c {bar p} and {pi}{sup {minus}} beams has been investigated in an experiment conducted at BNL AGS accelerator. All charged particles from protons to Z {approx_equal} 16 were detected using the Indiana Silicon Sphere 4{pi} array. Significant enhancement of energy deposition in high multiplicity events is observed for antiprotons compared to other hadron beams. The experimental trends are qualitatively consistent with predictions from an intranuclear cascade code.

  1. Peripheral dose measurement with a MOSFET detector

    Energy Technology Data Exchange (ETDEWEB)

    Butson, Martin J. [Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong (China) and Department of Medical Physics, Illawarra Cancer Care Centre, Crown St., Wollongong, NSW 2500 (Australia)]. E-mail: butsonm@iahs.nsw.gov.au; Cheung, Tsang [Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong (China); Yu, Peter K.N. [Department of Physics and Materials Science, City University of Hong Kong, Kowloon Tong, Hong Kong (China)

    2005-04-01

    The accuracy of a MOSFET dosimetry system with respect to peripheral therapeutic doses from high-energy X-rays has been evaluated . The results have been compared with ionisation chamber measurements in the same peripheral regions of the beam. For 6 MV and 18 MV X-ray beams, the MOSFET system in the high-sensitivity mode produces reproducibility of dose measurement with relative standard deviations within 1% of the maximal dose in the beam{sub ,} if the measurement is made upto 15 cm away from the beam edge. The results have shown that the MOSFET device can adequately measure peripheral doses, which would be beneficial for in vivo dose assessments in radiotherapy.

  2. Peripheral dose measurement with a MOSFET detector

    International Nuclear Information System (INIS)

    The accuracy of a MOSFET dosimetry system with respect to peripheral therapeutic doses from high-energy X-rays has been evaluated . The results have been compared with ionisation chamber measurements in the same peripheral regions of the beam. For 6 MV and 18 MV X-ray beams, the MOSFET system in the high-sensitivity mode produces reproducibility of dose measurement with relative standard deviations within 1% of the maximal dose in the beam, if the measurement is made upto 15 cm away from the beam edge. The results have shown that the MOSFET device can adequately measure peripheral doses, which would be beneficial for in vivo dose assessments in radiotherapy

  3. Measurement of antiproton-proton cross sections at low momenta

    International Nuclear Information System (INIS)

    The present thesis describes an experiment which serves for the study of the antiproton-proton interaction at laboratory momenta between 150 MeV/c and 600 MeV/c. The arrangement permits the measurement of differential cross sections of the elastic scattering and the charge-exchange reaction as well as the cross section of the annihilation into charged and neutral pions. By the availability of an intense beam with low momentum uncertainty from the LEAR storage ring for low energy antiprotons at CERN a clear improvement of the measurement accuracy compared to earlier experiments at separated antiproton beams can be reached. A prototype of the antineutron calorimeter used for the measurement of the angular distribution of the charge-exchange reaction was subjected to a careful test in a separated beam. The results were compared with the results of a Monte-Carlo simulation of the antineutron detection. The cross sections measured in two beam periods in November and December 1983 are consistent with the published data in the hitherto available momentum range above about 350 MeV/c. Especially in the cross section of the annihilation into charged pions a statistically significant signal at a mass of 1937 MeV/c2 appears. However further measurements are necessary to study all systematic causes of errors. (orig.)

  4. Interpretation of the cosmic ray positron and antiproton fluxes

    CERN Document Server

    Lipari, Paolo

    2016-01-01

    The spectral shape of cosmic ray positrons and antiprotons has been accurately measured in the broad kinetic energy range 1-350 GeV. In the higher part of this range (E > 30 GeV) the e+ and pbar are both well described by power laws with spectral indices gamma[e+] = 2.77 +-0.02 and gamma[pbar] = 2.78 +- 0.04 that are approximately equal to each other and to the spectral index of protons. In the same energy range the positron/antiproton flux ratio has the approximately constant value 2.04+-0.04, that is consistent with being equal to the ratio e_/pbar calculated for the conventional mechanism of production, where the antiparticles are created as secondaries in the inelastic interactions of primary cosmic rays with interstellar gas. The positron/antiproton ratio at lower energy is significantly higher (reaching the approximate value e+/pbar = 100 for E around 1 GeV), but in the entire energy range 1-350 GeV, the flux ratio is consistent with being equal to ratio of the production rates in the conventional mecha...

  5. Antihydrogen formation by autoresonant excitation of antiproton plasmas

    International Nuclear Information System (INIS)

    In efforts to trap antihydrogen, a key problem is the vast disparity between the neutral trap energy scale (∼ 50 μeV), and the energy scales associated with plasma confinement and space charge (∼1 eV). In order to merge charged particle species for direct recombination, the larger energy scale must be overcome in a manner that minimizes the initial antihydrogen kinetic energy. This issue motivated the development of a novel injection technique utilizing the inherent nonlinear nature of particle oscillations in our traps. We demonstrated controllable excitation of the center-of-mass longitudinal motion of a thermal antiproton plasma using a swept-frequency autoresonant drive. When the plasma is cold, dense and highly collective in nature, we observe that the entire system behaves as a single-particle nonlinear oscillator, as predicted by a recent theory. In contrast, only a fraction of the antiprotons in a warm or tenuous plasma can be similarly excited. Antihydrogen was produced and trapped by using this technique to drive antiprotons into a positron plasma, thereby initiating atomic recombination. The nature of this injection overcomes some of the difficulties associated with matching the energies of the charged species used to produce antihydrogen.

  6. Time-dependent density functional calculation of the energy loss of antiprotons colliding with metallic nanoshells

    Energy Technology Data Exchange (ETDEWEB)

    Quijada, M. [Departamento de Fisica de Materiales, Facultad de Quimicas UPV/EHU, Apartado 1072, 20080 San Sebastian (Spain); Donostia International Physics Center DIPC, P. Manuel de Lardizabal 4, 20018 San Sebastian (Spain); Borisov, A.G. [Donostia International Physics Center DIPC, P. Manuel de Lardizabal 4, 20018 San Sebastian (Spain); Universite Paris-Sud, Laboratoire des Collisions Atomiques et Moleculaires (France); CNRS, UMR 8625, Laboratoire des Collisions Atomiques et Moleculaires, LCAM, Batiment 351, UPS-11, Orsay, 91405 Orsay Cedex (France); Muino, R.D. [Donostia International Physics Center DIPC, P. Manuel de Lardizabal 4, 20018 San Sebastian (Spain); Centro de Fisica de Materiales, Centro Mixto CSIC-UPV/EHU, Edificio Korta, Avenida de Tolosa 72, 20018 San Sebastian (Spain)

    2008-06-15

    Time-dependent density functional theory is used to study the interaction between antiprotons and metallic nanoshells. The ground state electronic properties of the nanoshell are obtained in the jellium approximation. The energy lost by the antiproton during the collision is calculated and compared to that suffered by antiprotons traveling in metal clusters. The resulting energy loss per unit path length of material in thin nanoshells is larger than the corresponding quantity for clusters. It is shown that the collision process can be interpreted as the antiproton crossing of two nearly bi-dimensional independent metallic systems. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  7. Charged pion albedo induced by cosmic antiproton interactions with the lunar surface

    International Nuclear Information System (INIS)

    We report the calculations of the energy spectra and fluxes of single and double albedo charged pions generated by cosmic proton and antiproton interactions with the lunar surface. Properties of such spectra and related fluxes are investigated in order to clarify some important facets of the antiproton detection via charged pion albedo flux from the lunar surface. Pion albedo measurement may represent a novel approach for the identification of cosmic antiprotons using the lunar surface as a calorimeter. Future scientific programs on the Moon designed to measure antiproton flux may benefit from the results of these calculations. (author)

  8. Measurement of cosmic ray antiprotons from 3.7 to 19 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Hof, M.; Pfeifer, C.; Menn, W.; Simon, M. [Siegen Univ. (Germany); Golden, R.L.; Stochaj, S.J. [New Mexico State Univ., Las Cruces, NM (United States). Particle Astrophysics Laboratory; Stephens, S.A. [Tata Institute of Fundamental Research, Bombay (International Commission on Radiation Units and Measurements); Basini, G.; Ricci, M. [INFN, Laboratori Nazionali, Frascati, Rome (Italy)

    1996-02-01

    The antiproton to proton ratio in the cosmic rays has been measured in the energy range from 3.7 to 19 GeV. This measurement was carried out using a balloon-borne superconducting magnetic spectrometer along with a gas Cherenkov counter, an imaging calorimeter and a time of flight scintillator system. The measured antiproton to proton ratio was determined to be 1.24 (+0.68, -0.51)X 10{sup -4}. The present result along with other recent observations show that the observed abundances of antiprotons are consistent with models, in which antiprotons are produced as secondaries during the propagation of cosmic rays in the galaxy.

  9. Capture, Electron-Cooling and Compression of Antiprotons in a Large Penning-Trap for Physics Experiments with an Ultra-Low Energy Extracted Antiproton Beam

    CERN Multimedia

    2002-01-01

    % PS200 \\\\ \\\\The availability of ultra-low energy antiprotons is a crucial ingredient for the execution of the gravity measurements PS200. We have developed a method to provide such low energy antiprotons based on a large Penning trap (the PS200 catching trap). This system can accept a fast-extracted pulse from LEAR, reduce the energy of the antiprotons in the pulse from 5.9~MeV to several tens of kilovolts using a degrading foil, and then capture the antiprotons in a large Penning trap. These antiprotons are cooled by electrons previously admitted to the trap and are collected in a small region at the center of the trap. We have demonstrated our capability to capture up to 1~million antiprotons from LEAR in a single shot, electron cool these antiprotons, and transfer up to 95\\% of them into the inner, harmonic region. A storage time in excess of 1 hour was observed. These results have been obtained with the cryogenic trap vacuum coupled to a room temperature vacuum at about l0$ ^- ^{1} ^0 $ Torr, which is an...

  10. Multiple collision effects on the antiproton production by high energy proton (100 GeV - 1000 GeV)

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Hiroshi; Powell, J.

    1987-01-01

    Antiproton production rates which take into account multiple collision are calculated using a simple model. Methods to reduce capture of the produced antiprotons by the target are discussed, including geometry of target and the use of a high intensity laser. Antiproton production increases substantially above 150 GeV proton incident energy. The yield increases almost linearly with incident energy, alleviating space charge problems in the high current accelerator that produces large amounts of antiprotons.

  11. Multiple collision effects on the antiproton production by high energy proton (100 GeV - 1000 GeV)

    International Nuclear Information System (INIS)

    Antiproton production rates which take into account multiple collision are calculated using a simple model. Methods to reduce capture of the produced antiprotons by the target are discussed, including geometry of target and the use of a high intensity laser. Antiproton production increases substantially above 150 GeV proton incident energy. The yield increases almost linearly with incident energy, alleviating space charge problems in the high current accelerator that produces large amounts of antiprotons

  12. Ionization of atomic hydrogen by 30 1000 keV antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Knudsen, H.; Mikkelsen, U.; Paludan, K. [Institute of Physics and Astronomy, University of Aarhus, DK-8000 Aarhus C (Denmark); Kirsebom, K.; Moller, S.P.; Uggerhoj, E. [Institute for Synchrotron Radiation, University of Aarhus, DK-8000 Aarhus C (Denmark); Slevin, J. [Department of Experimental Physics, St. Patrick`s College, Maynooth (Ireland); Charlton, M. [Department of Physics and Astronomy, University College London, London WC1E 6BT (United Kingdom); Morenzoni, E. [Paul Scherrer Institut, Villigen, CH-4234 (Switzerland)

    1995-06-05

    Ionization in collisions between antiprotons and atomic hydrogen is perhaps the least complicated and most fundamental process that can be treated by atomic-collision theory. We present measurements of the ionization cross section for 30--1000 keV antiprotons colliding with atomic hydrogen.

  13. A new cryogenic target and microwave cavity for hyperfine structure spectroscopy of antiprotonic helium

    International Nuclear Information System (INIS)

    Full text: A new cryostat with pulse tube refrigeration and gas-tight microwave cavity with a laser and antiproton window has been designed and built to study the hyperfine structure of antiprotonic helium-3. The improvements between this and the old system will be explained. (author)

  14. Antiproton small momentum transfer charge exchange scattering on protons at 30 GeV/c

    International Nuclear Information System (INIS)

    Antiproton charge exchange scattering on protons anti pp→anti nn is investigated with 30 GeV/c antiprotons at the IHEP accelerator. The experiment confirms the existence of a structure at small angles in the angular distribution of this reaction at high energies, observed earlier

  15. The PS 200 catching trap: A new tool for ultra-low energy antiproton physics

    International Nuclear Information System (INIS)

    Approximately one million antiprotons have been trapped and electron cooled in the PS200 catching trap from a single fast extracted pulse from LEAR. The system is described in detail, different extraction schemes are discussed, and possible applications of this instrument to ultra-low energy atomic and nuclear physics with antiprotons are mentioned

  16. FAIR - the Facility for Antiproton and Ion Research: the Universe in the Lab

    Science.gov (United States)

    Weissbach, F.

    2015-11-01

    As of the year 2018 the Facility for Antiproton and Ion Research (FAIR) will offer access to exotic ion beams and beams of antiproton of unprecedented luminosity. The facility currently under construction in Darmstadt, Germany, adjacent to the existing accelerator at the GSI Helmholtz Centre for Heavy-Ion Research, will serve several collaborations and fields simultaneously: atomic, hadron, nuclear, and plasma physics.

  17. Trapping of antiprotons -- a first step on the way to antihydrogen

    International Nuclear Information System (INIS)

    A first step towards producing and effectively utilizing antihydrogen atoms consists of trapping antiprotons. The immediate next step must then be to control, i.e. trap the produced antihydrogen. The current state of the art in trapping antiprotons and positrons is reviewed, and the challenges in trapping the resulting neutral particles are discussed

  18. Illuminating dark matter and primordial black holes with an interstellar antiproton spectrometer

    International Nuclear Information System (INIS)

    Interstellar antiproton fluxes can arise from dark matter annihilating or decaying into quarks or gluons that subsequently fragment into antiprotons. Evaporation of primordial black holes also can produce a significant antiproton cosmic-ray flux. Since the background of secondary antiprotons from spallation has an interstellar energy spectrum that peaks at 2 GeV and falls rapidly for energies below this, low-energy measurements of cosmic antiprotons are useful in the search for exotic antiproton sources. However, measurement of the flux near the earth is challenged by significant uncertainties from the effects of the solar wind. We suggest evading this problem and more effectively probing dark-matter signals by placing an antiproton spectrometer aboard an interstellar probe currently under discussion. We address the experimental challenges of a light, low-power-consuming detector, and present an initial design of such an instrument. This experimental effort could significantly increase our ability to detect, and have confidence in, a signal of exotic, nonstandard antiproton sources. Furthermore, solar modulation effects in the heliosphere would be better quantified and understood by comparing results to inverse modulated data derived from existing balloon and space-based detectors near the earth

  19. Measurements of cosmic ray antiprotons with PAMELA and studies of propagation models

    CERN Document Server

    Wu, Juan

    2012-01-01

    Studying the acceleration and propagation mechanisms of Galactic cosmic rays can provide information regarding astrophysical sources, the properties of our Galaxy, and possible exotic sources such as dark matter. To understand cosmic ray acceleration and propagation mechanisms, accurate measurements of different cosmic ray elements over a wide energy range are needed. The PAMELA experiment is a satellite-borne apparatus which allows different cosmic ray species to be identified over background. Measurements of the cosmic ray antiproton flux and the antiproton-to-proton flux ratio from 1.5 GeV to 180 GeV are presented in this thesis. Compared to previous experiments, PAMELA extends the energy range of antiproton measurements and provides significantly higher statistics. The derived antiproton flux and antiproton-to-proton flux ratio are consistent with previous measurements and generally considered to be produced as secondary products when cosmic ray protons and helium nuclei interact with the interstellar med...

  20. Segmented scintillation detectors with silicon photomultiplier readout for measuring antiproton annihilations

    CERN Document Server

    Sótér, A; Kobayashi, T; Barna, D; Horvath, D; Hori, M

    2014-01-01

    The Atomic Spectroscopy and Collisions Using Slow Antiprotons (ASACUSA) experiment at the Antiproton Decelerator (AD) facility of CERN constructed segmented scintillators to detect and track the charged pions which emerge from antiproton annihilations in a future superconducting radiofrequency Paul trap for antiprotons. A system of 541 cast and extruded scintillator bars were arranged in 11 detector modules which provided a spatial resolution of 17 mm. Green wavelength-shifting fibers were embedded in the scintillators, and read out by silicon photomultipliers which had a sensitive area of 1 x 1 mm^2. The photoelectron yields of various scintillator configurations were measured using a negative pion beam of momentum p ~ 1 GeV/c. Various fibers and silicon photomultipliers, fiber end terminations, and couplings between the fibers and scintillators were compared. The detectors were also tested using the antiproton beam of the AD. Nonlinear effects due to the saturation of the silicon photomultiplier were seen a...

  1. Antihydrogen and mirror-trapped antiproton discrimination: Discriminating between antihydrogen and mirror-trapped antiprotons in a minimum-B trap

    OpenAIRE

    Amole, C.; Andresen, G. B.; Ashkezari, M. D.; Baquero-Ruiz, M.; Bertsche, W.; Butler, E.; Cesar, C. L.; S. Chapman; Charlton, M.; Deller, A.; Eriksson, S.; Fajans, J.; Friesen, T.; Fujiwara, M. C.; Gill, D. R.

    2012-01-01

    Recently, antihydrogen atoms were trapped at CERN in a magnetic minimum (minimum-B) trap formed by superconducting octupole and mirror magnet coils. The trapped antiatoms were detected by rapidly turning off these magnets, thereby eliminating the magnetic minimum and releasing any antiatoms contained in the trap. Once released, these antiatoms quickly hit the trap wall, whereupon the positrons and antiprotons in the antiatoms annihilated. The antiproton annihilations produce easily detected s...

  2. Top Production at the Tevatron: The Antiproton Awakens

    CERN Document Server

    ,

    2016-01-01

    A long time ago, at a laboratory far, far away, the Fermilab Tevatron collided protons and antiprotons at $\\sqrt{s} = 1.96$ TeV. The CDF and D0 experiments each recorded datasets of about 10 fb$^{-1}$. As such experiments may never be repeated, these are unique datasets that allow for unique measurements. This presentation describes recent results from the two experiments on top-quark production rates, spin orientations, and production asymmetries, which are all probes of the $p\\bar{p}$ initial state.

  3. The antiproton depth–dose curve measured with alanine detectors

    CERN Document Server

    Bassler, Niels; Palmans, Hugo; Holzscheiter, Michael H; Kovacevic, Sandra

    2008-01-01

    n this paper we report on the measurement of the antiproton depth–dose curve, with alanine detectors. The results are compared with simulations using the particle energy spectrum calculated by FLUKA, and using the track structure model of Hansen and Olsen for conversion of calculated dose into response. A good agreement is observed between the measured and calculated relative effectiveness although an underestimation of the measured values beyond the Bragg-peak remains unexplained. The model prediction of response of alanine towards heavy charged particles encourages future use of the alanine detectors for dosimetry of mixed radiation fields.

  4. Pion production on exotic nuclei by antiproton annihilation

    International Nuclear Information System (INIS)

    Pion production by antiproton annihilation on neutron- or proton-rich nuclei is studied in a fully quantum mechanical description of the reaction process in terms of a distorted wave approach. The elementary elastic N-bar N and the N-bar N → nπ annihilation vertices are obtained from a t-matrix accounting for coupled channels effects. The theoretical amplitudes are used to derive a microscopic N-bar A optical model potential and the meson production vertices. Nuclear structure effects are taken into account microscopically. Results for meson production cross sections are presented.

  5. Propylthiouracil and peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    Valentina Van Boekel

    1992-06-01

    Full Text Available Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared. Therefore, we call attention for a possible toxic effect on peripheral nervous system caused by this drug.

  6. Peripheral Artery Disease

    Science.gov (United States)

    ... or atherectomy may be used to help improve blood flow. What is peripheral artery disease (PAD)? How is peripheral artery disease evaluated? How ... PAD are diabetes, smoking, high cholesterol and high blood pressure. Most cases occur in ... is peripheral artery disease evaluated? Several imaging tests can be used to ...

  7. Measurement of 0.25 endash 3.2 GeV antiprotons in the cosmic radiation

    International Nuclear Information System (INIS)

    The balloon-borne isotope matter-antimatter experiment (IMAX) was flown from Lynn Lake, Manitoba Canada on 16 endash 17 July 1992. Using velocity and magnetic rigidity to determine mass, we have directly measured the abundances of cosmic ray antiprotons and protons in the energy range from 0.25 to 3.2 GeV. Both the absolute flux of antiprotons and the antiproton/proton ratio are consistent with recent theoretical work in which antiprotons are produced as secondary products of cosmic ray interactions with the interstellar medium. This consistency implies a lower limit to the antiproton lifetime of ∼107 yr. copyright 1996 The American Physical Society

  8. Radiotherapy for Hodgkin lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Specht, Lena [Rigshospitalet Copenhagen Univ. (Denmark). Depts. of Oncology and Haematology; Yahalom, Joachim (eds.) [Memorial Sloan-Kettering Cancer, New York, NY (United States). Dept. of Radiation Oncology

    2011-07-01

    This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the background and rationale for the inclusion of radiotherapy in today's combined-modality approach, including special clinical situations such as Hodgkin lymphoma in children, in the pregnant patient, and in the elderly. Radiotherapy planning using state-of-the-art imaging, target definition, planning software, and treatment equipment is expounded in detail. Acute and long-term side effects of radiotherapy are analyzed, and the implications for modern radiotherapy approaches in Hodgkin lymphomas are explained. (orig.)

  9. Radiotherapy for Hodgkin lymphoma

    International Nuclear Information System (INIS)

    This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the background and rationale for the inclusion of radiotherapy in today's combined-modality approach, including special clinical situations such as Hodgkin lymphoma in children, in the pregnant patient, and in the elderly. Radiotherapy planning using state-of-the-art imaging, target definition, planning software, and treatment equipment is expounded in detail. Acute and long-term side effects of radiotherapy are analyzed, and the implications for modern radiotherapy approaches in Hodgkin lymphomas are explained. (orig.)

  10. Efficient accumulation of antiprotons and positrons, production of slow mono-energetic beams, and their applications

    CERN Document Server

    Yamazaki, Yasunori

    2004-01-01

    Recent progress of ASACUSA (Atomic Spectroscopy And Collisions Using Slow Antiprotons) project, particularly the antiproton trapping and slow antiproton production, is discussed. An RFQD (Radio Frequency Quadrupole Decelerator) installed in the ASACUSA beam line has an excellent deceleration efficiency of 25% providing 10-130keV antiprotons, which improves the final accumulation efficiency at least one and half orders of magnitude. The decelerated antiprotons are then injected in a large volume multiring trap, stored, and electron-cooled. About 1 million antiprotons are successfully accumulated per one AD shot and 10-500eV antiprotons are extracted as a mono-energetic beam. A UHV compatible positron accumulation is newly developed combining electron plasma and an ion cloud, which yields an accumulation rate as high as 400e **+s/mCi, two and a half orders of magnitude higher than other UHV compatible schemes. A new scheme to synthesize a spin-polarized antihydrogen beam is also discussed, which will play a vit...

  11. Beam Dynamics Studies and Design Optimisation of New Low Energy Antiproton Facilities

    CERN Document Server

    Resta-Lopez, Javier; Welsch, Carsten P

    2016-01-01

    Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of a large number of basic questions on fundamental interactions. This includes the static structure of antiprotonic atomic systems and the time-dependent quantum dynamics of correlated systems. The Antiproton Decelerator (AD) at CERN is currently the worlds only low energy antiproton factory dedicated to antimatter experiments. New antiproton facilities, such as the Extra Low ENergy Antiproton ring (ELENA) at CERN and the Ultra-low energy Storage Ring (USR) at FLAIR, will open unique possibilities. They will provide cooled, high quality beams of extra-low energy antiprotons at intensities exceeding those achieved presently at the AD by factors of ten to one hundred. These facilities, operating in the energy regime between 100 keV down to 20 keV, face several design and beam dynamics challenges, for example nonlinearities, space charge and scattering effects limiting beam life time....

  12. Antiproton production in Au + Au collisions at 11.7 A·GeV/c

    International Nuclear Information System (INIS)

    We investigated the dependence of antiproton yields on the number of wounded projectile nucleons (Nproj). The dN/dy/Nproj of antiprotons with the beam energy correction is almost constant from p+A to Si+A collisions, while it decreases in Au+Au collisions to 30-60% of the constant. Next, we have compared dependence of ratios of dN/dy, p-bar/π-, p/π-, K-/π-, K+/π-, and π+/π- at 1.2proj in Au+Au collisions. Only the ratio of p-bar/π- decreases rapidly, while the ratios of p/π-, K+/π-, and K-/π- increase, and π+/π- stays constant. These observations suggest that in the AGS energy regime, the absorption effect of antiprotons in Au+Au collisions is much stronger than in p+A and Si+A collisions. We have compared the antiproton data with the RQMD model. In RQMD, antiprotons are produced initially from multi-step excitation processes and some of them are absorbed by nucleons with free NN-bar annihilation cross sections. RQMD reproduces overall tendencies of antiproton yields from p+A to Au+Au collisions within 50%. Finally, we explored the relation between baryon densities and antiproton yields in A+A collisions. We used a model in a static participant volume with the RQMD initial production and the absorption length with the free NN-bar annihilation cross section. In the model, only the antiprotons produced around the surface of the participant volume can survive. The model reproduces the scaling of experimental antiproton yields with the 2/3 power of the number of participants. By comparing the model with the experimental data, it is found that the ratio of the mean baryon density to the surface baryon density is 3-4 independent of collision systems. (J.P.N.). 109 refs

  13. Antiproton magnetic moment determined from the HFS of p-bar He+

    International Nuclear Information System (INIS)

    We report a determination of the antiproton magnetic moment, measured in a three-body system, independent of previous experiments. We present results from a systematic study of the hyperfine (HF) structure of antiprotonic helium where we have achieved a precision more than a factor of 10 better than our first measurement. A comparison between the experimental results and three-body quantum electrodynamic (QED) calculations leads to a new value for the antiproton magnetic moment μsp-bar=-2.7862(83)μN, which agrees with the magnetic moment of the proton within 2.9x10-3.

  14. Absolute calibration of the antiproton detection efficiency for BESS below 1 GeV

    CERN Document Server

    Asaoka, Y; Yoshida, T; Abe, K; Anraku, K; Fujikawa, M; Fuke, H; Haino, S; Izumi, K; Maeno, T; Makida, Y; Matsui, N; Matsumoto, H; Matsunaga, H; Motoki, M; Nozaki, M; Orito, S; Sanuki, T; Sasaki, M; Shikaze, Y; Sonoda, T; Suzuki, J; Tanaka, K; Toki, Y; Yamamoto, A

    2001-01-01

    An accelerator beam experiment was performed using a low-energy antiproton beam to measure the antiproton detection efficiency of the BESS detector. Measured and calculated efficiencies derived from the BESS Monte Carlo simulation based on GEANT/GHEISHA showed good agreement. With the detailed verification of the BESS simulation, results demonstrate that the relative systematic error of detection efficiency derived from the BESS simulation is within 5 %, being previously estimated as 15 % which was the dominant uncertainty for measurements of cosmic-ray antiproton flux.

  15. Measurement of low-energy antiproton detection efficiency in BESS below 1 GeV

    CERN Document Server

    Asaoka, Y; Yoshida, T; Abe, K; Anraku, K; Fujikawa, M; Fuke, H; Haino, S; Izumi, K; Maeno, T; Makida, Y; Matsui, N; Matsumoto, H; Matsunaga, H; Motoki, M; Nozaki, M; Orito, S; Sanuki, T; Sasaki, M; Shikaze, Y; Sonoda, T; Suzuki, J; Tanaka, K; Toki, Y; Yamamoto, A

    2002-01-01

    An accelerator experiment was performed using a low-energy antiproton beam to measure antiproton detection efficiency of BESS, a balloon-borne spectrometer with a superconducting solenoid. Measured efficiencies showed good agreement with calculated ones derived from the BESS Monte Carlo simulation based on GEANT/GHEISHA. With detailed verification of the BESS simulation, the relative systematic error of detection efficiency derived from the BESS simulation has been determined to be +-5%, compared with the previous estimation of +-15% which was the dominant uncertainty for measurements of cosmic-ray antiproton flux.

  16. Contribution of radiotherapy to the treatment of malignant tumors, 3. Combined drugs and radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Niibe, Hideo; Takahashi, Iku; Tamaki, Yoshio (Gunma Univ., Maebashi (Japan). School of Medicine)

    1984-09-01

    Effects of cytotoxic agent, hormone, hypoxic cell sensitizer, and radiation protector combined with radiation therapy in cancer management were analysed. The results were as follows: 1) An increase in response was seen in 25% or more of tumor nodules given radiotherapy combined with misonidazole, anoxic cell sensitizer, compared with radiotherpy alone. But the drug was also found to be neurotoxic and peripheral neuropathy. 2) Evidence has been given that Amifostine may protect the mucosal damage from radiation when Amifostine prior to irradiation was administrated to patients with tumor in the head and neck or in the pelvis. 3) There were no difference between five year survival of radiotherapy alone and with chemotherapy for patients with stage I Non-Hodgkin lymphoma. Chemotherapy following radiotherapy for patients with stage II was more effective treatment method than radiotherapy alone. 4) Radiotherapy for patients with prostate cancer was performed to control only primary site. The success rates of local control were over 80%. The near future holds extensive promise for a combination of radiation therapy, cytotoxic chemotherapy, hormone therapy, hypoxic cell sensitizer, and radiation protectors. All of these when used in the appropriate circumstances may yield significant improvements in the therapeutic ratio and in the long-tern control of tumors.

  17. Radiotherapy of anal carcinomas

    International Nuclear Information System (INIS)

    Report is given on radiotherapy of anal carcinomas. Own experiences and a review of the recent literature are presented. Prior to surgery radiotherapy with high energy electrons in combination with chemotherapy is in the foreground. Especially in cloacogenous carcinoma no residual tumor was found after preliminary irradiation. Our recommended conception of post-operative radiotherapy of the regional lymphatic draining vessels is outlined. (orig./MG)

  18. Fermilab Antiproton Source, Recycler Ring, and Main Injector

    CERN Document Server

    Nagaitsev, Sergei

    2014-01-01

    At the end of its operations in 2011, the Fermilab antiproton production complex consisted of a sophisticated target system, three 8-GeV storage rings (namely the Debuncher, the Accumulator and the Recycler), 25 independent multi-GHz stochastic cooling systems, the world's only relativistic electron cooling system and a team of technical experts equal to none. The accelerator complex at Fermilab supported a broad physics program including the Tevatron Collider Run II, neutrino experiments using 8-GeV and 120-GeV proton beams, as well as a test beam facility and other fixed target experiments using 120-GeV primary proton beams. This paper provides a brief description of Fermilab accelerators as they operated at the end of the Collider Run II (2011).

  19. Transport from the Recycler Ring to the Antiproton Source Beamlines

    CERN Document Server

    Xiao, M

    2013-01-01

    In the post-Nova era, the protons are directly transported from the Booster ring to the Recycler ring rather than the Main Injector. For Mu2e and g-2 project, the Debuncher ring will be modified into a Delivery ring to deliver the protons to both Mu2e and g-2 experiemnts. Therefore, It requires the transport of protons from the Recycler Ring to the Delivery ring. A new transfer line from the Recycler ring to the P1 beamline will be constructed to transport proton beam from the Recycler Ring to existing Antiproton Source beamlines. This new beamline provides a way to deliver 8 GeV kinetic energy protons from the Booster to the Delivery ring, via the Recycler, using existing beam transport lines, and without the need for new civil construction. This paper presents the Conceptual Design of this new beamline.

  20. Pulsed septum magnet for the Fermilab antiproton source

    International Nuclear Information System (INIS)

    A 2 meter curved pulsed septum magnet for use in the Fermilab Antiproton Source is described. The magnet produces a peak field of 6 kGauss at a current of 20,000 Amperes within a 0.4 msec long pulse. The field uniformity obtained is ΔB/B<0.2% out to 3.8 cm from the copper septum. Power enters the magnet from the center resulting in very simple ends and the magnet incorporates at 0.5 cm steel guard which reduces the field to <1.4 Gauss in the zero-field region. The total septum thickness is 1.3 cm. The vacuum enclosure doubles as the stacking fixture for the magnet laminations allowing easy assembly of a magnet with a 50 m radius of curvature

  1. Survey and alignment of the Fermilab recycler antiproton storage ring

    International Nuclear Information System (INIS)

    In June of 1999 Fermilab commissioned a newly constructed antiproton storage ring, the 'Recycler Ring', in the Main Injector tunnel directly above the Main Injector beamline. The Recycler Ring is a fixed 8 GeV kinetic energy storage ring and is constructed of strontium ferrite permanent magnets. The 3319.4-meter-circumference Recycler Ring consists of 344 gradient magnets and 100 quadrupoles all of which are permanent magnets. This paper discusses the methods employed to survey and align these permanent magnets within the Recycler Ring with the specified accuracy. The Laser Tracker was the major instrument used for the final magnet alignment. The magnets were aligned along the Recycler Ring with a relative accuracy of ±0.25 mm. (author)

  2. An Update on the Depth-Dose Curve of Antiprotons

    DEFF Research Database (Denmark)

    Taasti, Vicki Trier; Holzscheiter, Michael H.; Knudsen, Helge;

    improves the situation, in particular on the upstream side of the Bragg-peak. This is attributed to a different spectrum of annihilation products created in the entrance window of the ionization chamber in comparison to the case of simply simulating annihilation taking place on water. Yet, a large portion...... of dose still is missing in the Bragg-peak. This effect is also visible in the tail where the dose is underestimated in both types of simulations because of the missing annihilation energy/products. Conclusions: The shape of the Bragg-peak has some dependence on what material the antiprotons is...... simulated dose to dose-to-water formalism. Results: Generally, the experimental data are in good agreement with the simulated dose on an absolute scale in the plateau region. However some deviations are found near the annihilation peak. A full geometric description of the ionization chamber simulation...

  3. One-Particle Measurement of the Antiproton Magnetic Moment

    CERN Document Server

    DiSciacca, J; Marable, K; Gabrielse, G; Ettenauer, S; Tardiff, E; Kalra, R; Fitzakerley, D W; George, M C; Hessels, E A; Storry, C H; Weel, M; Grzonka, D; Oelert, W; Sefzick, T

    2013-01-01

    The antiproton $(\\bar{p})$ magnetic moment $\\mu \\bar{p} = \\mu_{\\bar{p}} S/(\\bar{h}/2)$ is proportional to its spin $S$. A single trapped $\\bar{p}$ is used for the first time to measure the $\\bar{p}$ magnetic moment in nuclear magnetons, giving $\\mu_\\bar{p}/\\mu N = -2.792 845 \\pm 0.000 012$. The 4.4 parts per million (ppm) uncertainty is 680 times smaller than previously realized. Comparing to the proton moment $\\mu_{p} = \\mu_{p} S/\\bar{h}/2)$ measured using the same method and trap electrodes gives $\\mu_{\\bar{p}}/\\mu_{p} = -1.000 000 \\pm 0.000 005$ to 5 ppm, consistent with the prediction of the CPT theorem.

  4. Decay of hot nuclei formed with energetic antiprotons (PS208)

    CERN Document Server

    Pienkowski, L; Eades, John; Egidy, T V; Figuera, P; Fuchs, H; Galin, J; Goldenbaum, F; Golubeva, Y S; Gulda, K; Hilscher, D; Iljinov, A S; Jahnke, U; Jastrzebski, J J; Kurcewicz, W; Lott, B; Morjean, M; Pausch, G; Peghaire, A; Polster, D; Proschitzki, S; Quednau, B; Rossner, H; Schmid, S; Schmid, W; Ziem, P

    1999-01-01

    Energetic antiproton-nucleus interactions allow to build up thermal excitation energies exceeding 800 MeV in nuclei of masses close to 200. We found that for these high excitation energies the fission process still remains a very significant exit channel. At excitation energies close to 800 MeV the fission process approaches 20-50% of the cross section for Ho, Au and U-like nuclei depending on the fission events selection criteria. The average intermediate mass fragment multiplicity at such high excitation energies is equal to about 1 and alpha particle multiplicity is equal to about 5 for all three reactions independently of the exit channel, including fission. A transition towards the multifragmentation is not observed.

  5. Quality Assurance in Radiotherapy

    Science.gov (United States)

    Mckenzie, Alan

    A common feature of the Radiotherapy Centres where there have been major accidents involving incorrect radiotherapy treatment is that they did not operate good Quality Assurance systems. A Quality Assurance system is sometimes called a Quality Management system, and it is designed to give assurance that quality standards are being met. One of the "spin offs" from operating a Quality Management system is that it reduces the likelihood of a radiotherapy accident. A detailed account of how to set up a quality system in radiotherapy has been given in an ESTRO booklet.2

  6. Radiotherapy of Cervical Cancer.

    Science.gov (United States)

    Vordermark, Dirk

    2016-01-01

    Curative-intent radical radiotherapy of cervical cancer consists of external-beam radiotherapy, brachytherapy, and concomitant chemotherapy with cisplatin. For each element, new developments aim to improve tumor control rates or treatment tolerance. Intensity-modulated radiotherapy (IMRT) has been shown to reduce gastrointestinal toxicity and can be used to selectively increase the radiotherapy dose. Individualized, image-guided brachytherapy enables better adaptation of high-dose volumes to the tumor extension. Intensification of concomitant or sequential systemic therapy is under evaluation. PMID:27614991

  7. Antiproton-nucleus interaction: review of the experimental situation

    International Nuclear Information System (INIS)

    This paper will review the experimental situation of a few well-defined channels of the anti-p-nucleus interaction where the antiproton does not annihilate. It will not mention any experiment which studies annihilation of antiporotons in nuclei. The anti-p-nucleus reactions that will be reviewed are the following: 1. A(anti-p,anti-p)A elastic scattering which deals with the anti-p-nucleus system in a positive energy state. 2. Anti-p-nucleus atoms where the anti-p-nucleus system is almost at zero energy and interacts mostly through the Coulomb interaction, the strong interaction being only a perturbation. 3. A(anti-p,p)X proton knock-out reaction used to produce possible bound states or resonances of the anti-p-nucleus system via strong interaction. The main reasons for studying these three channels are to provide information about the anti-p-nucleus optical potential and also, through microscopic calculations which use the elementary anti-NN amplitudes and the nuclear matter densities as inputs, to get information about these quantities. 4. A(anti-p,anti-p')A* inelastic scattering - inelastic in the sense that the nucleus is left in an excited state but the antiproton does not annihilate, that is it deals only with the elastic part of the elementary anti-NN amplitude. Inelastic scattering from collective states also sets constraints on the anti-p-nucleus potential when analysed in terms of coupled-channel calculations. When unnatural parity states are concerned, it provides a sensitive test of the spin and isospin components of these amplitudes. In addition, this paper will focus essentially on the recent experiments performed at LEAR

  8. Spin Filtering of Stored (Anti)Protons: from FILTEX to COSY to AD to FAIR

    International Nuclear Information System (INIS)

    We review the theory of spin filtering of stored (anti) protons by multiple passage through a polarized internal target (PIT). The implications for the antiproton polarization buildup in the proposed PAX experiment at FAIR are discussed

  9. On the Utility of Antiprotons as Drivers for Inertial Confinement Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, L J; Orth, C D; Tabak, M

    2003-10-20

    By contrast to the large mass, complexity and recirculating power of conventional drivers for inertial confinement fusion (ICF), antiproton annihilation offers a specific energy of 90MJ/{micro}g and thus a unique form of energy packaging and delivery. In principle, antiproton drivers could provide a profound reduction in system mass for advanced space propulsion by ICF. We examine the physics underlying the use of antiprotons ({bar p}) to drive various classes of high-yield ICF targets by the methods of volumetric ignition, hotspot ignition and fast ignition. The useable fraction of annihilation deposition energy is determined for both {bar p}-driven ablative compression and {bar p}-driven fast ignition, in association with 0-D and 1-D target burn models. Thereby, we deduce scaling laws for the number of injected antiprotons required per capsule, together with timing and focal spot requirements. The kinetic energy of the injected antiproton beam required to penetrate to the desired annihilation point is always small relative to the deposited annihilation energy. We show that heavy metal seeding of the fuel and/or ablator is required to optimize local deposition of annihilation energy and determine that a minimum of {approx}3x10{sup 15} injected antiprotons will be required to achieve high yield (several hundred megajoules) in any target configuration. Target gains - i.e., fusion yields divided by the available p - {bar p} annihilation energy from the injected antiprotons (1.88GeV/{bar p}) - range from {approx}3 for volumetric ignition targets to {approx}600 for fast ignition targets. Antiproton-driven ICF is a speculative concept, and the handling of antiprotons and their required injection precision - temporally and spatially - will present significant technical challenges. The storage and manipulation of low-energy antiprotons, particularly in the form of antihydrogen, is a science in its infancy and a large scale-up of antiproton production over present supply

  10. Proton and antiproton production in deep inelastic muon-nucleon scattering at 280 GeV

    International Nuclear Information System (INIS)

    New results on proton and antiproton production in the target and current fragmentation regions of high energy muonnucleon scattering are presented. Proton and antiproton production is investigated as a function of Feynman x and rapidity. No significant difference is observed between production on hydrogen and deuterium targets. Correlations between pp, panti p and anti panti p pairs are analysed and the results are compared with the predictions of the Lund fragmentation model. (orig.)

  11. Proton and antiproton production in deep inelastic muon-nucleon scattering at 280 GeV

    Science.gov (United States)

    Arneodo, M.; Arvidson, A.; Aubert, J. J.; Badelek, B.; Beaufays, J.; Bee, C. P.; Benchouk, C.; Berghoff, G.; Bird, I.; Blum, D.; Böhm, E.; de Bouard, X.; Brasse, F. W.; Braun, H.; Broll, C.; Brown, S.; Brück, H.; Calen, H.; Chima, J. S.; Ciborowski, J.; Clifft, R.; Coignet, G.; Combley, F.; Coughlan, J.; D'Agostini, G.; Dahlgren, S.; Dengler, F.; Derado, I.; Dreyer, T.; Drees, J.; Düren, M.; Eckardt, V.; Edwards, A.; Edwards, M.; Ernst, T.; Eszes, G.; Favier, J.; Ferrero, M. I.; Figiel, J.; Flauger, W.; Foster, J.; Gabathuler, E.; Gajewski, J.; Gamet, R.; Gayler, J.; Geddes, N.; Grafström, P.; Grard, F.; Haas, J.; Hagberg, E.; Hasert, F. J.; Hayman, P.; Heusse, P.; Jaffré, M.; Jacholkowska, A.; Janata, F.; Jansco, G.; Johnson, A. S.; Kabuss, E. M.; Kellner, G.; Korbel, V.; Krüger, A.; Krüger, J.; Kullander, S.; Landgraf, U.; Lanske, D.; Loken, J.; Long, K.; Maire, M.; Malecki, P.; Manz, A.; Maselli, S.; Mohr, W.; Montanet, F.; Montgomery, H. E.; Nagy, E.; Nassalski, J.; Norton, P. R.; Oakham, F. G.; Osborne, A. M.; Pascaud, C.; Pawlik, B.; Payre, P.; Peroni, C.; Peschel, H.; Pessard, H.; Pettingale, J.; Pietrzyk, B.; Poensgen, B.; Pötsch, M.; Renton, P.; Ribarics, P.; Rith, K.; Rondio, E.; Sandacz, A.; Scheer, M.; Schlagböhmer, A.; Schiemann, H.; Schmitz, N.; Schneegans, M.; Scholz, M.; Schouten, M.; Schröder, T.; Schultze, K.; Sloan, T.; Stier, H. E.; Studt, M.; Taylor, G. N.; Thénard, J. M.; Thompson, J. C.; de La Torre, A.; Toth, J.; Urban, L.; Wallucks, W.; Whalley, M.; Wheeler, S.; Williams, W. S. C.; Wimpenny, S. J.; Windmolders, R.; Wolf, G.

    1987-12-01

    New results on proton and antiproton production in the target and current fragmentation regions of high energy muon-nucleon scattering are presented. Proton and antiproton production is investigated as a function of Feynman x and rapidity. No significant difference is observed between production on hydrogen and deuterium targets. Correlations between pp,pbar p andbar pbar p pairs are analysed and the results are compared with the predictions of the Lund fragmentation model.

  12. Antiproton, positron, and electron imaging with a microchannel plate/phosphor detector

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jørgensen, L V; Kerrigan, S J; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; van der Werf, D P; Yamazaki, Y

    2009-01-01

    A microchannel plate (MCP)/phosphor screen assembly has been used to destructively measure the radial profile of cold, confined antiprotons, electrons, and positrons in the ALPHA experiment, with the goal of using these trapped particles for antihydrogen creation and confinement. The response of the MCP to low energy (10-200 eV, <1 eV spread) antiproton extractions is compared to that of electrons and positrons.

  13. First measurement of the antiproton-nucleus annihilation cross section at 125 keV

    CERN Document Server

    Aghai-Khozani, H; Corradini, M; De Salvador, D; Hayano, R; Hori, M; Kobayashi, T; Leali, M; Lodi-Rizzini, E; Mascagna, V; Prest, M; Seiler, D; Soter, A; Todoroki, K; Vallazza, E; Venturelli, L

    2015-01-01

    The first observation of in-flight antiproton-nucleus annihilation at ∼130 keV obtained with the ASACUSA detector has demonstrated that the measurement of the cross section of the process is feasible at such extremely low energies Aghai-Khozani, H., et al., Eur. Phys. J. Plus 127, 55 (2012). Here we present the results of the data analysis with the evaluations of the antiproton annihilation cross sections on carbon, palladium and platinum targets at 125 keV.

  14. Study of X-Ray and $\\gamma$-Ray Spectra from Antiprotonic Atoms at the Slowly Extracted Antiproton Beam of LEAR

    CERN Multimedia

    2002-01-01

    This experiment will study the X-ray spectra of antiprotonic atoms and the $\\gamma$ spectra of residual nuclei after the antiproton absorption. We intend to begin with measurements on selected isotopically pure targets. Strong interaction effects, the antiproton absorption and the atomic cascade are analysed through the measurement of energies, lineshapes, relative and absolute intensities of all observable lines. The experiments are continued to determine st in resolved fine structure levels and in different isotopes of the same element. Coincidence techniques may be applied. All components of the experimental set-up are already existing from previous experiments and we could begin the measurements with any slowly extracted beam of low energy at LEAR.

  15. Technical design report for the PANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker. Strong interaction studies with antiprotons

    International Nuclear Information System (INIS)

    This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described. (orig.)

  16. P-986 Letter of Intent: Medium-Energy Antiproton Physics at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Asner, David M.; /Carleton U.; Phillips, Thomas J.; /Duke U.; Apollinari, Giorgio; Broemmelsiek, Daniel R.; Brown, Charles N.; Christian, David C.; Derwent, Paul; Gollwitzer, Keith; Hahn, Alan; Papadimitriou, Vaia; Stefanski, Ray; /Fermilab /INFN, Ferrara /Hbar Technol., West Chicago /IIT, Chicago /CHEP, Taegu /Luther Coll. /Michigan U. /Northwestern U. /Notre Dame U. /St. Xavier U., Chicago

    2009-02-05

    Fermilab has long had the world's most intense antiproton source. Despite this, the opportunities for medium-energy antiproton physics at Fermilab have been limited in the past and - with the antiproton source now exclusively dedicated to serving the needs of the Tevatron Collider - are currently nonexistent. The anticipated shutdown of the Tevatron in 2010 presents the opportunity for a world-leading medium-energy antiproton program. We summarize the current status of the Fermilab antiproton facility and review some physics topics for which the experiment we propose could make the world's best measurements. Among these, the ones with the clearest potential for high impact and visibility are in the area of charm mixing and CP violation. Continued running of the Antiproton Source following the shutdown of the Tevatron is thus one of the simplest ways that Fermilab can restore a degree of breadth to its future research program. The impact on the rest of the program will be minor. We request a small amount of effort over the coming months in order to assess these issues in more detail.

  17. New Calculation of Antiproton Production by Cosmic Ray Protons and Nuclei

    Science.gov (United States)

    Kachelriess, Michael; Moskalenko, Igor V.; Ostapchenko, Sergey S.

    2015-04-01

    A dramatic increase in the accuracy and statistics of space-borne cosmic ray (CR) measurements has yielded several breakthroughs over the last several years. The most puzzling is the rise in the positron fraction above ∼10 GeV over the predictions of the propagation models assuming pure secondary production. The accuracy of the antiproton production cross section is critical for astrophysical applications and searches for new physics since antiprotons in CRs seem to hold the keys to many puzzles including the origin of those excess positrons. However, model calculations of antiproton production in CR interactions with interstellar gas are often employing parameterizations that are out of date or are using outdated physical concepts. This may lead to an incorrect interpretation of antiproton data which could have broad consequences for other areas of astrophysics. In this work, we calculate antiproton production in pp-, pA-, and AA-interactions using EPOS-LHC and QGSJET-II-04, two of the most advanced Monte Carlo (MC) generators tuned to numerous accelerator data including those from the Large Hadron Collider (LHC). We show that the antiproton yields obtained with these MC generators differ by up to an order of magnitude from yields of parameterizations commonly used in astrophysics.

  18. Interaction of antiprotons with Rb atoms and a comparison of antiproton stopping powers of the atoms H, Li, Na, K, and Rb

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Fischer, Nicolas; Saenz, Alejandro

    Ionization and excitation cross sections as well as electron-energy spectra and stopping powers of the alkali metal atoms Li, Na, K, and Rb colliding with antiprotons were calculated using a time-dependent channel-coupling approach. An impact-energy range from 0.25 to 4000 keV was considered. The...... target atoms are treated as effective one-electron systems using a model potential. The results are compared with calculated cross sections for antiproton-hydrogen atom collisions....

  19. 3.4 Radiotherapy

    Science.gov (United States)

    Kramer, H.-M.; Selbach, H.-J.; Vatnitsky, S.

    This document is part of Subvolume A 'Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and Medical Radiological Protection' of Volume 7 'Medical Radiological Physics' of Landolt-Börnstein - Group VIII 'Advanced Materials and Technologies'. It contains the Section '3.4 Radiotherapy' of the Chapter '3 Dosimetry in Diagnostic Radiology and Radiotherapy' with the contents:

  20. Training logbook for radiotherapy.

    NARCIS (Netherlands)

    Hunter, R.; Maciejewski, B.; Leer, J.W.H.; Kinay, M.; Heeren, G.

    2004-01-01

    AIM: To develop a structured logbook for trainees in the medical specialty of radiotherapy with Europe that records the increasing experience throughout their training period. MATERIAL AND METHODS: A working party appointed by the European Board of Radiotherapy developed a draft version of a Europea

  1. Antitumor radiotherapy in children

    International Nuclear Information System (INIS)

    The philosophy is outlined of the therapy of malignant tumors in children, including Hodgkin type lymphomas and non-Hodgkin tumors, such as Wilm's tumor. The role of radiotherapy is defined and discussed in the comprehensive management of children using a combined radiotherapy-chemotherapy system. (L.O.). 5 refs

  2. [Radiotherapy of skin cancers].

    Science.gov (United States)

    Hennequin, C; Rio, E; Mahé, M-A

    2016-09-01

    The indications of radiotherapy for skin cancers are not clearly defined because of the lack of randomised trials or prospective studies. For basal cell carcinomas, radiotherapy frequently offers a good local control, but a randomized trial showed that surgery is more efficient and less toxic. Indications of radiotherapy are contra-indications of surgery for patients older than 60, non-sclerodermiform histology and occurring in non-sensitive areas. Adjuvant radiotherapy could be proposed to squamous cell carcinomas, in case of poor prognostic factors. Dose of 60 to 70Gy are usually required, and must be modulated to the size of the lesions. Adjuvant radiotherapy seems beneficial for desmoplastic melanomas but not for the other histological types. Prophylactic nodal irradiation (45 to 50Gy), for locally advanced tumours (massive nodal involvement), decreases the locoregional failure rate but do not increase survival. Adjuvant radiotherapy (50 to 56Gy) for Merckel cell carcinomas increases also the local control rate, as demonstrated by meta-analysis and a large epidemiological study. Nodal areas must be included, if there is no surgical exploration (sentinel lymph node dissection). Kaposi sarcomas are radiosensitive and could be treated with relatively low doses (24 to 30Gy). Also, cutaneous lymphomas are good indications for radiotherapy: B lymphomas are electively treated with limited fields. The role of total skin electron therapy for T-lymphomas is still discussed; but palliative radiotherapy is very efficient in case of cutaneous nodules. PMID:27522189

  3. To understand radiotherapy

    International Nuclear Information System (INIS)

    Dealing with the use of radiotherapy for adults, this guide indicates when a radiotherapy is suggested, how it acts, how the treatment is chosen, which are the professionals involved. It describes how an external radiotherapy takes place and its various techniques, the different types of side effects (general, specific to the treated zone, late effects). It indicates which organs can be treated by curie-therapy, the different curie-therapy treatment modalities, how a curie-therapy takes place and which are its side effects. It outlines how to better cope with radiotherapy (how to be supported, the important role of relatives, everyday life questions, rights). It indicates and comments the different measures adopted for the safety and quality of radiotherapy

  4. Direct High-Precision Measurement of the g-Factor of a Single Antiproton Stored in a Cryogenic Penning Trap

    CERN Document Server

    Ulmer, S; Blaum, K; Quint, W; Walz, J

    2012-01-01

    We propose a direct high-precision measurement of the magnetic moment, or g-factor, of a single antiproton stored in a cryogenic Penning trap. Currently the most precise value of the magnetic moment of the antiproton is extracted from hyperfine spectroscopy of antiprotonic helium atoms, and known with a relative precision of $10^{-3}$, only . With the experiment proposed in this Letter of Intent we aim at a measurement with a relative precision of $10^{-9}$ or better.

  5. A high-intensity low-momentum separated antiproton beam for the study of annihilations at rest

    CERN Document Server

    Bassompierre, G; Dalpiaz, P; Dalpiaz, P F; Ferro-Luzzi, M; Gissinger, G; Jacquey, S; Peroni, C; Schmitt, F M; Schneegans, M; Tecchio, L B

    1977-01-01

    The main features of the low-momentum separated antiproton beam built at the CERN Proton Synchrotron to allow the stopping of a large number of antiprotons are described. An effective stopping rate of 1000 antiproton per 10/sup 12/ protons on the Ps internal target is obtained. Results of the measurement of the rate of reaction pp to h /sup +/h/sup -/ in a 50 cm long liquid hydrogen target are given to illustrate the stopping and monitoring techniques. (6 refs).

  6. Donating Peripheral Blood Stem Cells

    Science.gov (United States)

    ... this page Print this page Donating peripheral blood stem cells Peripheral blood stem cell (PBSC) donation is a nonsurgical procedure to collect ... Donating bone marrow Donor experiences videos Peripheral blood stem cell (PBSC) donation is one of two methods of ...

  7. Advances of Precise Radiotherapy for Lung Cancer

    OpenAIRE

    Xin WANG; Xu, Feng; Wei, Yuquan

    2011-01-01

    At present lung tumor radiation therapy has entered the accurate radiotherapy era. Precise radiotherapy includes intensity modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT) and stereotactic body radiotherapy (SBRT). During the process of implementing precise radiotherapy, these problems should be fully considered to ensure executing precise radiotherapy accurately: patient positioning, controlling of the lung tumor motion, selecting of image techniques, PTV margin, dose prescrip...

  8. Intensity-modulated stereotactic body radiotherapy for stage I non-small cell lung cancer

    OpenAIRE

    Kim, Min-Jeong; Yeo, Seung-Gu; KIM, EUN SEOK; MIN, CHUL KEE; SE AN, PYUNG

    2012-01-01

    This study aimed to investigate the clinical outcomes of intensity-modulated radiotherapy (IMRT)-based stereotactic body radiotherapy (SBRT) for patients with stage I non-small cell lung cancer (NSCLC). A prospective database of 16 consecutive patients receiving SBRT for pathologically-proven and peripherally-located stage I NSCLC was reviewed. Fifteen patients were medically inoperable and one patient refused to undergo surgery. The median age of the patients was 76 years (range, 69–86). Tre...

  9. Peripheral Arterial Disease

    Science.gov (United States)

    Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of ... smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, ...

  10. Peripheral Ulcerative Keratitis

    Science.gov (United States)

    ... 2 Diabetes, Heart Disease a Dangerous Combo Are 'Workaholics' Prone to OCD, Anxiety? ALL NEWS > Resources First ... unless they are treated. Rheumatoid arthritis is what causes peripheral ulcerative keratitis and death due to a ...

  11. Occlusive Peripheral Arterial Disease

    Science.gov (United States)

    ... erythrocyte sedimentation rate (ESR) and level of C-reactive protein, which is produced only when inflammation is present. ... people with occlusive peripheral arterial disease also have coronary artery disease. Amputation of a limb may be necessary if ...

  12. First observation of two hyperfine transitions in antiprotonic 3He

    International Nuclear Information System (INIS)

    We report on the first experimental results for microwave spectroscopy of the hyperfine structure of p-bar3He+. Due to the helium nuclear spin, p-bar3He+ has a more complex hyperfine structure than p-bar4He+, which has already been studied before. Thus a comparison between theoretical calculations and the experimental results will provide a more stringent test of the three-body quantum electrodynamics (QED) theory. Two out of four super-super-hyperfine (SSHF) transition lines of the (n,L)=(36,34) state were observed. The measured frequencies of the individual transitions are 11.12559(14) GHz and 11.15839(18) GHz, less than 1 MHz higher than the current theoretical values, but still within their estimated errors. Although the experimental uncertainty for the difference of these frequencies is still very large as compared to that of theory, its measured value agrees with theoretical calculations. This difference is crucial to be determined because it is proportional to the magnetic moment of the antiproton.

  13. Time purified/separated antiproton beam at the AGS

    International Nuclear Information System (INIS)

    A 1 km antiproton beam has been designed for construction at the AGS. The momentum band can be varied between +-0.3% to +-1.0%, and the resolution for tagged particles will be deltap/p approx. 10-4 at beam rates as high as 106 anti p/s. Separation by decay purification will be on the order of 1 anti p/10(π-+μ-). This beam will be used in a detailed investigation of Charmonium including a measurement of the chi widths. We will also search for expected but as yet unseen states, and search for possible I=1 events which would imply the existence of four quark states. This facility will also lend itself to a wide variety of exciting physics such as the proton form factor including both e+e- and γγ final states, two-body hadron final states, anti-nucleus yields, and possibly tagged hadron beams (i.e., Lambda, E, etc.). When heavy ions become available at the AGS, one can measure various long lived particle yields. Finally, with as many as 107 polarized muons in the beam, one has the possibility to use them for nuclear structure studies

  14. Constraining pre-big-bang nucleosynthesis expansion using cosmic antiprotons

    International Nuclear Information System (INIS)

    A host of dark energy models and nonstandard cosmologies predict an enhanced Hubble rate in the early Universe: perfectly viable models, which satisfy big bang nucleosynthesis (BBN), cosmic microwave background and general relativity tests, may nevertheless lead to enhancements of the Hubble rate up to many orders of magnitude. In this paper we show that strong bounds on the pre-BBN evolution of the Universe may be derived, under the assumption that dark matter is a thermal relic, by combining the dark matter relic density bound with constraints coming from the production of cosmic-ray antiprotons by dark matter annihilation in the Galaxy. The limits we derive apply to the Hubble rate around the temperature of dark matter decoupling. For dark matter masses lighter than 100 GeV, the bound on the Hubble rate enhancement ranges from a factor of a few to a factor of 30, depending on the actual cosmological model, while for a mass of 500 GeV the bound falls in the range 50-500. Uncertainties in the derivation of the bounds and situations where the bounds become looser are discussed. We finally discuss how these limits apply to some specific realizations of nonstandard cosmologies: a scalar-tensor gravity model, kination models and a Randall-Sundrum D-brane model

  15. Subthreshold antiproton and K- production in heavy ion collisions

    International Nuclear Information System (INIS)

    Subthreshold anti p and K- and energetic π- production was studied in Ne + NaF, Cu, Sn and Bi, and in Ni + Ni collisions with incident energies between 1.6 and 2 GeV/u. The measured cross sections indicate a dominant contribution of baryonic resonances. This is also consistent with a generalized scaling behaviour of the cross sections with the energy available in the collision and the energy necessary to produce particles as observed with Ne induced reactions. Deviations from scaling especially pronounced in the Ni-Ni system will be discussed in terms of absorption effects. The flat slope of the excitation function for anti p production is only understood with a reduced production threshold in the nuclear medium caused by a reduction of the antiproton mass in the dense and heated medium by about 100-150 MeV/c2. A similar in-medium mass reduction is also indicated for K- mesons. The dependence of the anti p yield on the system size is considerably weaker than expected from a simple fireball model, indicating increased reabsorption in Ni + Ni compared to Ne + NaF. (orig.)

  16. Studying the potential of antihyperons in nuclei with antiprotons

    International Nuclear Information System (INIS)

    The interaction between an antibaryon and a nucleus may shed light on the short range antibaryon-baryon force in a unique way. However, because of the deep imaginary part of the nuclear potential of antibaryons, the physics of antihyperons in nuclei is hitherto an uncharted territory. Recently it was proposed to use transverse momentum correlations of exclusively produced antihyperon-hyperon pairs in antiproton-nucleus collisions to obtain information on the antihyperon potentials relative to that of the corresponding hyperon. In the present study we use the Giessen Boltzmann-Uehling- Uhlenbeck Transportmodell (GiBUU) to explore the production of exclusive hyperon-antihyperon pairs close to threshold. Unlike the schematic calculation, these GiBBU simulations take e.g. important rescattering effects into account. In case of anti p + 20Ne → anti ΛΛ+X we confirm a significant sensitivity of transverse momentum correlations to the nuclear potential of Λs. We also explore the feasibility of such measurements at the PANDA experiment of the international facility FAIR.

  17. Near-threshold behavior of positronium-antiproton scattering

    Science.gov (United States)

    Fabrikant, I. I.; Bray, A. W.; Kadyrov, A. S.; Bray, I.

    2016-07-01

    Using the convergent close-coupling theory we study the threshold behavior of cross sections for positronium (Ps) of energy E scattering on antiprotons. In the case of Ps (1 s ) elastic scattering, simple power laws are observed for all partial waves studied. The partial-wave summed cross section is nearly constant, and dominates the antihydrogen formation cross section at all considered energies, even though the latter is exothermic and behaves as 1 /E1 /2 . For Ps (2 s ), oscillations spanning orders of magnitude on top of the 1 /E behavior are found in the elastic and quasielastic cross sections. The antihydrogen formation is influenced by dipole-supported resonances below the threshold of inelastic processes. Resonance energies form a geometric progression relative to the threshold. The exothermic antihydrogen formation cross sections behave as 1 /E at low energies, but are oscillation free. We demonstrate that all these rich features are reproduced by the threshold theory developed by Gailitis [J. Phys. B: At. Mol. Phys. 15, 3423 (1982), 10.1088/0022-3700/15/19/012].

  18. Constraining pre big-bang-nucleosynthesis expansion using cosmic antiprotons

    International Nuclear Information System (INIS)

    A host of dark energy models and non-standard cosmologies predict an enhanced Hubble rate in the early Universe: perfectly viable models, which satisfy Big Bang Nucleosynthesis (BBN), cosmic microwave background and general relativity tests, may nevertheless lead to enhancements of the Hubble rate up to many orders of magnitude. In this paper we show that strong bounds on the pre-BBN evolution of the Universe may be derived, under the assumption that dark matter is a thermal relic, by combining the dark matter relic density bound with constraints coming from the production of cosmic-ray antiprotons by dark matter annihilation in the Galaxy. The limits we derive can be sizable and apply to the Hubble rate around the temperature of dark matter decoupling. For dark matter masses lighter than 100 GeV, the bound on the Hubble-rate enhancement ranges from a factor of a few to a factor of 30, depending on the actual cosmological model, while for a mass of 500 GeV the bound falls in the range 50-500. Uncertainties in the derivation of the bounds and situations where the bounds become looser are discussed. We finally discuss how these limits apply to some specific realizations of non-standard cosmologies: a scalar-tensor gravity model, kination models and a Randall-Sundrum D-brane model. (Orig.)

  19. Elastic scattering, polarization and absorption of relativistic antiprotons on nuclei

    CERN Document Server

    Larionov, A B

    2016-01-01

    We perform Glauber model calculations of the antiproton-nucleus elastic and quasielastic scattering and absorption in the beam momentum range $\\sim 0.5\\div10$ GeV/c. A good agreement of our calculations with available LEAR data and with earlier Glauber model studies of the $\\bar p A$ elastic scattering allows us to make predictions at the beam momenta of $\\sim 10$ GeV/c, i.e at the regime of the PANDA experiment at FAIR. The comparison with the proton-nucleus elastic scattering cross sections shows that the diffractive minima are much deeper in the $\\bar p A$ case due to smaller absolute value of the ratio of the real-to-imaginary part of the elementary elastic amplitude. Significant polarization signal for $\\bar p A$ elastic scattering at 10 GeV/c is expected. We have also revealed a strong dependence of the $\\bar p A$ absorption cross section on the slope parameter of the transverse momentum dependence of the elementary $\\bar pN$ amplitude. The $\\bar p A$ optical potential is discussed.

  20. Antiproton constraints on dark matter annihilations from internal electroweak bremsstrahlung

    International Nuclear Information System (INIS)

    If the dark matter particle is a Majorana fermion, annihilations into two fermions and one gauge boson could have, for some choices of the parameters of the model, a non-negligible cross-section. Using a toy model of leptophilic dark matter, we calculate the constraints on the annihilation cross-section into two electrons and one weak gauge boson from the PAMELA measurements of the cosmic antiproton-to-proton flux ratio. Furthermore, we calculate the maximal astrophysical boost factor allowed in the Milky Way under the assumption that the leptophilic dark matter particle is the dominant component of dark matter in our Universe. These constraints constitute very conservative estimates on the boost factor for more realistic models where the dark matter particle also couples to quarks and weak gauge bosons, such as the lightest neutralino which we also analyze for some concrete benchmark points. The limits on the astrophysical boost factors presented here could be used to evaluate the prospects to detect a gamma-ray signal from dark matter annihilations at currently operating IACTs as well as in the projected CTA

  1. Spectroscopy of the hyperfine structure of antiprotonic 4He and 3He

    International Nuclear Information System (INIS)

    The spin magnetic moment μsp-bar of the antiproton can be determined by comparing the measured transition frequencies in p-bar4 He +  with three-body QED calculations. A comparison between the proton and antiproton can then be used as a test of CPT invariance. The highest measurement precision of the difference between the proton and the antiproton spin magnetic moments to date is 0.3%. A new experimental value of the spin magnetic moment of the antiproton was obtained as μsp-bar = -2.7862(83)/muN , slightly better than the previously best measurement. This agrees with μsp within 0.24%. In 2009, a new measurement with antiprotonic 3He has been started. A comparison between the theoretical calculations and experimental results would lead to a stronger test of the theory and address systematic errors therein. A measurement of this state will be the first HF measurement on p-bar3 He + . We report here on the new experimental setup and the first tests.

  2. Modeling of the Near-Earth Low-Energy Antiproton Fluxes

    Directory of Open Access Journals (Sweden)

    U. B. Jayanthi

    2011-01-01

    Full Text Available The local interstellar antiproton spectrum is simulated taking into account antineutron decay, (He,p interaction, secondary and tertiary antiproton production, and the solar modulation in the “force field” approximation. Inclusive invariant cross-sections were obtained through a Monte Carlo procedure using the Multistage Dynamical Model code simulating various processes of the particle production. The results of the simulations provided flux values of 4⋅10−3 to 10−2 and 10−2 to 1.7⋅10−2 antiprotons/(2 s sr GeV at energies of 0.2 and 1 GeV, respectively, for the solar maximum and minimum epochs. Simulated flux of the trapped antiprotons in the inner magnetosphere due to galactic cosmic ray (GCR interactions with the atmospheric constituents exceeds the galactic antiproton flux up to several orders. These simulation results considering the assumptions with the attendant limitations are in comprehensive agreement with the experimental data including the PAMELA ones.

  3. ELENA: the extra low energy anti-proton facility at CERN

    CERN Document Server

    Maury, Stephan; Bartmann, Wolfgang; Belochitskii, Pavel; Breuker, Horst; Butin, Francois; Carli, Christian; Eriksson, Tommy; Pasinelli, Sergio; Tranquille, Gerard

    2014-01-01

    At the last LEAP conference in Vancouver 2011 the authors stated that a project ”ELENA”, as an abbreviation for Extra Low ENergy Antiproton ring and as first discussed in 1982 for LEAR by H. Herr et al., was freshly proposed with a substantial new design and revised layout and that it was under consideration to be built at CERN. ELENA is an upgrade of the Anti-proton Decelerator (AD) at CERN and is devoted to special experiments with physics using low energy anti-protons. The main topics are the anti-hydrogen production and consecutive studies of the features of this anti-matter atom as well as the anti-proton nucleon interaction by testing the QED to high precision. During the last years the project underwent several steps in presentations at different committees at CERN and was finally approved such that the construction has started. ELENA will increase the number of useful anti-protons by about two orders of magnitude and will allow to serve up to four experiments simultaneously. Very first and convinc...

  4. Normal tissue tolerance to external beam radiation therapy: Peripheral nerves

    International Nuclear Information System (INIS)

    Plexopathies and peripheral neuropathies appear progressively and with several years delay after radiotherapy. These lesions are observed principally after three clinical situations: supraclavicular and axillar irradiations for breast cancer, pelvic irradiations for various pathologies and limb irradiations for soft tissue sarcomas. Peripheral nerves and plexus (brachial and lumbosacral) are described as serial structures and are supposed to receive less than a given maximum dose linked to the occurrence of late injury. Literature data, mostly ancient, define the maximum tolerable dose to a threshold of 60 Gy and highlight also a great influence of fractionation and high fraction doses. For peripheral nerves, most frequent late effects are pain with significant differences of occurrence between 50 and 60 Gy. At last, associated pathologies (diabetes, vascular pathology, neuropathy) and associated treatments have probably to be taken into account as additional factors, which may increase the risk of these late radiation complications. (authors)

  5. DICOM in Radiotherapy

    Directory of Open Access Journals (Sweden)

    A. Nikfarjam

    2007-08-01

    Full Text Available Noticeable development in achieving data from patients is acquired by means of designing a system that connects these systems: imaging, archive and monitoring systems. When several imaging devices work based on DICOM standard; they can connect to each other without any interface. There are many applications for DICOM standard in radiotherapy; however its main usage is in imaging. It has other applications such as RT Structure Set, RT Dose, RT Plan and RT Brachy Treatment. "nNow DICOM is a complete and widespread standard to use in radiotherapy. Most of the radiotherapy machines have ability to use DICOM. Before installing a new Linac, it is necessary to predict all aspects of DICOM standard in this device. Therefore, as regards to entrance of 12 Linac to Iran, it is important to have enough knowledge about it. This article is a review about development of DICOM in radiotherapy. We try to stress on DICOM applications and abstain from technological agenda.

  6. Radiotherapy cure: safety

    International Nuclear Information System (INIS)

    In radiotherapy, a precisely measured dose of ionising radiation is directed at a limited tumour area so as not to damage healthy tissues. The most important form of therapy is external radiation therapy given by means of radiotherapy equipment. The bigger the tumour, the more cancer cells it contains and the higher the radiation dose that is needed to destroy the tumour. Different cancer types respond differently to radiation. Healthy tissues also respond in different ways to radiotherapy, e.g. the reaction may come during the treatment or later. The growth of some cancer types accelerates in two to four weeks after the initiation of the therapy. This information has brought about a reduction in treatment times so as to avoid cell growth that might endanger the treatment result. The radiotherapy that is given today by specialist doctors is safe because the side effects of the treatment are well under control. (orig.)

  7. Antiproton Production in 11.5 A GeV/c Au+Pb Nucleus-Nucleus Collisions

    OpenAIRE

    E687 Collaboration; al, T. A. Armstrong et

    1997-01-01

    We present the first results from the E864 collaboration on the production of antiprotons in 10% central 11.5 A GeV/c Au+Pb nucleus collisions at the Brookhaven AGS. We report invariant multiplicities for antiproton production in the kinematic region 1.4

  8. Status of antiproton accumulation and cooling at Fermilab's Recycler

    Energy Technology Data Exchange (ETDEWEB)

    Prost, L.R.; Bhat, C.M.; Broemmelsiek, D.; Burov, A.; Carlson, K.; Crisp, J.; Derwent, P.; Eddy, N.; Gattuso, C.; Hu, M.; Pruss, S.; /Fermilab

    2009-08-01

    The Recycler ring is an 8 GeV permanent magnet storage ring where antiprotons are accumulated and prepared for Fermilab's Tevatron Collider program. With the goal of maximizing the integrated luminosity delivered to the experiments, storing, cooling and extracting antiprotons with high efficiency has been pursued. Over the past two years, while the average accumulation rate doubled, the Recycler continued to operate at a constant level of performance thanks to changes made to the Recycler Electron Cooler (energy stability and regulation, electron beam optics), RF manipulations and operating procedures. In particular, we discuss the current accumulation cycle in which {approx} 400 x 10{sup 10} antiprotons are accumulated and extracted to the Tevatron every {approx}15 hours.

  9. Secondary antiproton flux induced by cosmic ray interactions with the atmosphere

    International Nuclear Information System (INIS)

    The atmospheric secondary antiproton flux is studied for detection altitudes extending from sea level up to about three earth radii, by means of a three-dimensional Monte Carlo simulation, successfully applied previously to other satellite and balloon data. The calculated antiproton flux at mountain altitude is found to be in fair agreement with the recent BESS measurements. The flux obtained at balloon altitude is also in agreement with calculations performed in previous studies and used for the analysis of balloon data. The flux at sea level is found to be significant. The antineutron flux is also evaluated. The antiproton flux is prospectively explored up to around 2x104 km from the Earth. The results are discussed in the context of the forthcoming measurements by large acceptance experiments

  10. A fussy revisitation of antiprotons as a tool for Dark Matter searches

    CERN Document Server

    Boudaud, Mathieu

    2015-01-01

    Antiprotons are regarded as a powerful probe for Dark Matter (DM) indirect detection and indeed current data from \\PAMELA\\ have been shown to lead to stringent constraints. However, in order to exploit their constraining/discovery power properly, great attention must be put into effects (linked to their propagation in the Galaxy) which may be perceived as subleading but actually prove to be quite relevant. We revisit the computation of the astrophysical background and of the DM antiproton fluxes fully including the effects of: diffusive reacceleration, energy losses including tertiary component and solar modulation (in a force field approximation). Using the updated proton and helium fluxes just released by the \\AMS\\ experiment we reevaluate the secondary astrophysical antiproton to proton ratio and its uncertainties, and compare it with the ratio preliminarly reported by \\AMS. We find no unambiguous evidence for a significant excess with respect to expectations. Yet, some preference for a flatter energy depe...

  11. Parallel plate chambers for monitoring the profiles of high-intensity pulsed antiproton beams

    CERN Document Server

    Hori, Masaki

    2004-01-01

    Two types of beam profile monitor with thin parallel-plate electrodes have been used in experiments carried out at the Low Energy Antiproton Ring (LEAR) and Antiproton Decelerator (AD) of CERN. The detectors were used to measure non-destructively the spatial profiles, absolute intensities, and time structures of 100-300-ns- long beam pulses containing between 10**7 and 10**9 antiprotons. The first of these monitors was a parallel plate ionization chamber operated at gas pressure P=65 mbar. The other was a secondary electron emission detector, and was operated in the ultra-high vacuum of the AD. Both designs may be useful in medical and commercial applications. The position-sensitive electrodes in these detectors were manufactured by a novel method in which a laser trimmer was used to cut strip patterns on metallized polyester foils.

  12. The Concept of Antiproton Accumulation in the RESR Storage Ring of the FAIR Project

    CERN Document Server

    Steck, Markus; Dolinskyy, Oleksiy; Franzke, Bernhard; Katayama, Takeshi; Litvinov, Sergey; Nolden, Fritz; Peschke, Claudius; Mohl, Dieter; Thorndahl, Lars

    2010-01-01

    The RESR storage ring of the FAIR projectwas designed for use as an accumulator ring for antiprotons. Therefore its optical design offers a large momentum acceptance and large flexibility in the choice of the working point. This is crucial, if longitudinal stacking with a stochastic cooling system is planned. The accumulation system has been studied in simulations which include both the properties of the optical design and details of the stochastic cooling system. The simulations confirm that the stochastic cooling system can support the accumulation with a repetition rate of 10 s for the injection of pre-cooled batches of 108 antiprotons from the collector ring CR. A maximum of intensity of 1011 accumulated antiprotons can be achieved as required for high luminosity experiments

  13. Measurements of electron spectra in the forward direction in slow-antiproton carbon-foil collisions

    International Nuclear Information System (INIS)

    The spectra of electrons emitted in the forward direction from antiproton and proton bombardments on carbon foils have been studied for projectile energies from 500 to 750 keV. Our main observation is that at the electron energy where the well-known convoy peak is observed for proton impact, the spectrum for equivelocity antiprotons is smooth, showing no indication of a deep anticusp. However, around 50 eV below the electron energy where the cusp is observed for proton impact, we have observed a small peak for antiproton impact. The energy and the relative intensity of the bump are found to be consistent with those predicted for electrons released from a wakeriding state. (author)

  14. Peripheral neuroepithelioma of the kidney.

    OpenAIRE

    Kim, K W; Ha, D. H.; Jung, W. H.

    1995-01-01

    Peripheral neuroepithelioma is a rare tumor, comprising less than 1% of all soft tissue malignancies arising from the peripheral nonautonomic nervous system. Most peripheral neuroepitheliomas reported were located in the extremities, thoraco-pulmonary region, and pelvic areas, and as many as 30% of cases were associated with peripheral nerve. We report one case of peripheral neuroepithelioma arising in the kidney, mimicking renal cell carcinoma on the CT scan.

  15. Analysis of Subthreshold Antiproton Production in p-Nucleus and Nucleus-Nucleus Collisions in the RBUU Approach

    CERN Document Server

    Teis, S; Maruyama, T; Mosel, U; Teis, Stefan; Cassing, Wolfgang; Maruyama, Tomoyuki; Mosel, Ulrich

    1994-01-01

    We calculate the subthreshold production of antiprotons in the Lorentz-covariant RBUU approach employing a weighted testparticle method to treat the antiproton propagation and absorption nonperturbatively. We find that the pbar differential cross sections are highly sensitive to the baryon and antiproton selfenergies in the dense baryonic environment. Adopting the baryon scalar and vector selfenergies from the empirical optical potential for proton-nucleus elastic scattering and from Dirac-Brueckner calculations at higher density rho > rho_0 we examine the differential pbar spectra as a function of the antiproton selfenergy. A detailed comparison with the available experimental data for p-nucleus and nucleus-nucleus reactions shows that the antiproton feels a moderately attractive mean-field at normal nuclear matter density rho_0 which is in line with a dispersive potential extracted from the free annihilation cross section.

  16. The experiment PANDA: physics with antiprotons at FAIR

    Science.gov (United States)

    Boca, Gianluigi

    2015-05-01

    PANDA is an experiment that will run at the future facility FAIR, Darmstadt, Germany. A high intensity and cooled antiproton beam will collide on a fixed hydrogen or nuclear target covering center-of-mass energies between 2.2 and 5.5 GeV. PANDA addresses various physics aspects from the low energy non-perturbative region towards the perturbative regime of QCD. With the impressive theoretical developments in this field, e.g. lattice QCD, the predictions are becoming more accurate in the course of time. The data harvest with PANDA will, therefore, be an ideal test bench with the aim to provide a deeper understanding of hadronic phenomena such as confinement and the generation of hadron masses. A variety of physics topics will be covered with PANDA, for example: the formation or production of exotic non-qqbar charm meson states connected to the recently observed XYZ spectrum; the study of gluon-rich matter, such as glueballs and hybrids; the spectroscopy of the excited states of strange and charm baryons, their production cross section and their spin correlations; the behaviour of hadrons in nuclear matter; the hypernuclear physics; the electromagnetic proton form factors in the timelike region. The PANDA experiment is designed to achieve the above mentioned physics goals with a setup with the following characteristics: an almost full solid angle acceptance; excellent tracking capabilities with high resolution (1-2 % at 1 GeV/c in the central region); secondary vertex detection with resolution ≈ 100 microns or better; electromagnetic calorimetry for detections of gammas and electrons up to 10 GeV; good particle identification of charge tracks (electrons, muons, pions, kaons, protons); a dedicated interchangeable central apparatus for the hypernuclear physics; detector and data acquisition system capable of working at 20 MHz interaction rate with an intelligent software trigger that can provide maximum flexibility.

  17. Constructions of Peripherality

    DEFF Research Database (Denmark)

    Carter, Helen Frances Lindsay

    2013-01-01

    rural area of Northern Ireland, and the manner in which peripherality is constructed by a variety of different actors in this debate. In the case discussed in the article, peripherality is constructed in different ways by different actors, yet the debate becomes somewhat polarised into the environmental......In this paper I focus on the concept of peripheralisation. In particular, I consider how peripheries can be discursively constructed in the debates surrounding planning cases, and how this might serve to legitimate particular interests. This is related to the case of a proposed golf resort in a...... values of a periphery versus the ‘need’ for economic development in such a periphery. In this paper I will analyse these constructions of peripherality and discuss the manner in which different framings of the region affects planning, and perhaps legitimates certain developments. This offers a...

  18. Neutron density distributions from antiprotonic 208Pb and 209Bi atoms

    OpenAIRE

    Klos, B.; Trzcinska, A.; Jastrzebski, J.; Czosnyka, T.; Kisielinski, M.; Lubinski, P.; Napiorkowski, P.; Pienkowski, L.; Hartmann, F. J.; Ketzer, B.; Ring, P.; Schmidt, R.; von Egidy, T.; Smolanczuk, R.; S. Wycech

    2007-01-01

    The X-ray cascade from antiprotonic atoms was studied for 208Pb and 209Bi. Widths and shifts of the levels due to the strong interaction were determined. Using modern antiproton-nucleus optical potentials the neutron densities in the nuclear periphery were deduced. Assuming two parameter Fermi distributions (2pF) describing the proton and neutron densities the neutron rms radii were deduced for both nuclei. The difference of neutron and proton rms radii /\\r_np equal to 0.16 +-(0.02)_{stat} +-...

  19. Centrifugal separation and equilibration dynamics in an electron-antiproton plasma

    CERN Document Server

    Andresen, G B; Baquero-Ruiz, Marcelo; Bertsche, William; Bowe, Paul D; Butler, Eoin; Cesar, Claudio L; Chapman, Steven; Charlton, Michael; Deller, A; Eriksson, S; Fajans, Joel; Friesen, Tim; Fujiwara, Makoto C; Gill, David R; Gutierrez, A; Hangst, Jeffrey S; Hardy, Walter N; Hayden, Michael E; Humphries, Andrew J; Hydomako, Richard; Jonsell, Svante; Madsen, Niels; Menary, Scott; Nolan, Paul; Olin, Art; Povilus, Alexander; Pusa, Petteri; Robicheaux, Francis; Sarid, Eli; Silveira, Daniel M; So, Chukman; Storey, James W; Thompson, Robert I; van der Werf, Dirk P; Wurtele, Jonathan S; Yamazaki, Yasunori

    2011-01-01

    Charges in cold, multiple-species, non-neutral plasmas separate radially by mass, forming centrifugally-separated states. Here, we report the first detailed measurements of such states in an electron-antiproton plasma, and the first observations of the separation dynamics in any centrifugally-separated system. While the observed equilibrium states are expected and in agreement with theory, the equilibration time is approximately constant over a wide range of parameters, a surprising and as yet unexplained result. Electron-antiproton plasmas play a crucial role in antihydrogen trapping experiments.

  20. Longitudinal momentum mining of antiprotons at the Fermilab Recycler: past, present and future

    Energy Technology Data Exchange (ETDEWEB)

    Bhat, C.M.; Chase, B.E.; Gattuso, C.; Joireman, P.W.; /Fermilab

    2007-06-01

    The technique of longitudinal momentum mining (LMM)[1] in the Fermilab Recycler was adopted in early 2005 to extract thirty-six equal intensity and equal 6D-emittance antiproton bunches for proton-antiproton collider operation in the Tevatron. Since that time, several improvements have been made in the Recycler and the mining technique to handle higher intensity beams. Consequently, the Recycler has become a key contributor to the increased luminosity performance observed during Tevatron Run IIb. In this paper, we present an overview of the improvements and the current status of the momentum mining technique.

  1. Collisions of low-energy antiprotons with molecular hydrogen: ionization, excitation and stopping power

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2009-01-01

    A time-dependent coupled-channel approach was used to calculate ionization, excitation, and energy-loss cross sections as well as energy spectra for antiproton and proton collisions with molecular hydrogen for impact energies 8 < E < 4000 keV.......A time-dependent coupled-channel approach was used to calculate ionization, excitation, and energy-loss cross sections as well as energy spectra for antiproton and proton collisions with molecular hydrogen for impact energies 8 < E < 4000 keV....

  2. Experimental setup and first measurement of DNA damage induced along and around an antiproton beam

    DEFF Research Database (Denmark)

    Kavanagh, J. N.; Currell, F. J.; Timson, D. J.;

    2010-01-01

    directly and indirectly exposed human fibroblasts irradiated in both plateau and Bragg peak regions of a 126 MeV antiproton beam at CERN. Cells were stained post irradiation with an anti-γ-H2AX antibody. Quantification of the γ-H2AX foci-dose relationship is consistent with a linear increase in the Bragg...... peak region. A qualitative analysis of the foci detected in the Bragg peak and plateau region indicates significant differences highlighting the different severity of DNA lesions produced along the particle path. Irradiation of desalted plasmid DNA with 5 Gy antiprotons at the Bragg peak resulted in a...

  3. Small angle elastic scattering at the CERN proton-antiproton collider

    International Nuclear Information System (INIS)

    Proton-antiproton elastic scattering at a centre of mass energy √s=540 GeV has been studied at low momentum transfer. The measured value of the logarithmic slope of the differential elastic cross-section, b = 17.1 +- 0.9 GeV-2 for 0.04 2, b = 12.9 +- 0.3 GeV-2 for 0.19 2 confirms the previous evidence from the UA1 and UA4 collaborations for an increase at small t. A preliminary estimate of the proton-antiproton total cross-section shows an increase of about 50% from ISR to Collider energy. (orig.)

  4. Proton-Antiproton Pair Production in Two-Photon Collisions at LEP

    CERN Document Server

    Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; van Dalen, J A; De Asmundis, R; Déglon, P L; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Duda, M; Echenard, B; Eline, A; El-Hage, A; El-Mamouni, H; Engler, A; Eppling, F J; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisher, W; Fisk, I; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hakobyan, R S; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Hu, Y; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Käfer, D; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V F; Kräber, M H; Krämer, R W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Luci, C; Luminari, L; Lustermann, W; Ma Wen Gan; Malgeri, L; Malinin, A; Maña, C; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musicar, B; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nisati, A; Nowak, H; Ofierzynski, R A; Organtini, G; Pal, I; Palomares, C; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofev, D; Prokofiev, D O; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Roth, S; Rosenbleck, C; Rubio, J A; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Schäfer, C; Shchegelskii, V; Schopper, Herwig Franz; Schotanus, D J; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, Ludwig; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R; Veszpremi, V; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wang, Q; Wang, X L; Wang, Z M; Weber, M; Wienemann, P; Wilkens, H; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

    2003-01-01

    The reaction e+e- -> e+e- proton antiproton is studied with the L3 detector at LEP. The analysis is based on data collected at e+e- center-of-mass energies from 183 GeV to 209 GeV, corresponding to an integrated luminosity of 667 pb-1. The gamma gamma -> proton antiproton differential cross section is measured in the range of the two-photon center-of-mass energy from 2.1 GeV to 4.5 GeV. The results are compared to the predictions of the three-quark and quark-diquark models.

  5. Longitudinal momentum mining of antiprotons at the Fermilab Recycler: past, present and future

    International Nuclear Information System (INIS)

    The technique of longitudinal momentum mining (LMM)[1] in the Fermilab Recycler was adopted in early 2005 to extract thirty-six equal intensity and equal 6D-emittance antiproton bunches for proton-antiproton collider operation in the Tevatron. Since that time, several improvements have been made in the Recycler and the mining technique to handle higher intensity beams. Consequently, the Recycler has become a key contributor to the increased luminosity performance observed during Tevatron Run IIb. In this paper, we present an overview of the improvements and the current status of the momentum mining technique

  6. Anti-proton production and annihilation in nuclear collisions at 15-A/GeV

    OpenAIRE

    Jahns, André; Stöcker, Horst; Greiner, Walter; Sorge, Heinz

    2006-01-01

    We present a calculation of antiproton yields in Si+Al and Si+Au collisions at 14.5A GeV in the framework of the relativistic quantum molecular dynamics approach (RQMD). Multistep processes lead to the formation of high-mass flux tubes. Their decay dominates the initial antibaryon yield. However, the subsequent annihilation in the surrounding baryon-rich matter suppresses the antiproton yield considerably: Two-thirds of all antibaryons are annihilated even for the light Si+Al system. Comparis...

  7. The ratio Ri for nondissociative ionization of molecular hydrogen by antiproton/proton impact

    International Nuclear Information System (INIS)

    The theoretical ratio Ri of antiproton/proton cross sections for nondissociative ionization of hydrogen molecule has been obtained as a function of the impact energy E in the range 30 ≤ E ≤ 2500 keV lab. The required cross sections were computed in the close-coupling formulation of the semiclassical impact parameter theory using a simple one-active electron model for the molecular target. The ratio Ri is important for the analysis of the recent experimental data of Andersen et al. on antiproton scattering and the understanding of the collisional mechanisms in the keV range. (orig.)

  8. Antiproton Production in Au+Au Collisions at 11.7a GeV/c

    International Nuclear Information System (INIS)

    Antiproton production in 11.7A GeV/c Au+Au collisions over a wide transverse-mass coverage was studied using the AGS-E866 experimental apparatus. The mean transverse kinetic energy increases as a function of centrality and is similar to that of protons. The antiproton yields in Si+Al , Si+Au , and Au+Au collisions are consistent with scaling with the 0.7 power of the number of participant nucleons. Copyright 1998, The American Physical Society

  9. Pion, Kaon, Proton and Antiproton Production in Proton-Proton Collisions

    Science.gov (United States)

    Norbury, John W.; Blattnig, Steve R.

    2008-01-01

    Inclusive pion, kaon, proton, and antiproton production from proton-proton collisions is studied at a variety of proton energies. Various available parameterizations of Lorentz-invariant differential cross sections as a function of transverse momentum and rapidity are compared with experimental data. The Badhwar and Alper parameterizations are moderately satisfactory for charged pion production. The Badhwar parameterization provides the best fit for charged kaon production. For proton production, the Alper parameterization is best, and for antiproton production the Carey parameterization works best. However, no parameterization is able to fully account for all the data.

  10. Observation of antiproton annihilation in heavy nuclei at 100 GeV/c

    International Nuclear Information System (INIS)

    We report on the observation of antiproton annihilation in Mg, Ag, and Au nuclei at 100 GeV/c. The experiment was performed with the Fermilab 30'' bubble chamber spectrometer and associated Downstream Particle Identifiers. By identifying events without a leading anti p or anti n we have determined that (39+-6)% of the antiprotons annihilate in a heavy nucleus. We present this fraction as a function of atomic mass number and discuss the associated charged particle multiplicity. 5 refs., 3 figs

  11. Advice concerning radiotherapy

    International Nuclear Information System (INIS)

    Dutch National cancer incidence figures were calculated by using the reliable data on cancer incidence in the Eindhoven area and population forecasts and information obtained from the Central Bureau of Statistics. Several radiotherapy departments suffer from under capacity (a lack of resources and understaffing). Data have also shown that 35% of cancer patients receive radiotherapy, instead of 50%. Calculations have been made by the committee on the present and future needs with regard to equipment and staff. In 1983, the number of megavoltage therapy units amounted to 38, but should have been 65. It should be 80 in 1990 and 90 in 2000. Since building and installing such equipment is a lengthy process a considerable effort is needed to make up for the arrears. The committee advocates the extension of the system of regional cooperation in cancer care (comprehensive cancer centres), in which radiotherapy departments play a crucial role. Working parties from the committee provided a comprehensive description of current radiotherapy practice with reference to physical, technical, clinical and management aspects. Another working party assessed the results of cancer treatment with regard to many different tumour sites. Recent and expected developments were analysed or indicated. The Radiotherapy Committee commissioned an external team to conduct a project to achieve a picture of future developments using methods different to those of the committee's. An interim advice has been added on this subject. (Auth.)

  12. Incident contamination lepton doses measured using radiochromic film in radiotherapy

    International Nuclear Information System (INIS)

    Measurement of lepton contamination is achieved across a radiotherapy photon beam and peripheral doses using radiochromic film. An extrapolation technique is used where several layers are suspended in air to measure incident contamination without the effects of phantom scatter. Surface dose was measured as 11% of Dmax for 6 MV beams at central axis and 9% for 10 MV photons for a 10x10 cm field size. Peripheral lepton doses were found to decrease compared to central, however, were still measurable. Peripheral lepton dose was found to increase with field size and was 12% and 15%, 2 cm outside the geometric field edge of a 30x30 cm field size at 6 and 10 MV respectively. Radiochromic film is a suitable dosimeter for measurement of lepton contamination absorbed dose to surface layers of skin

  13. Chemical modifiers of radiotherapy

    International Nuclear Information System (INIS)

    Only two groups, anticancer drugs and radiosensitizers are discussed among many groups of chemical modifiers. In combined radiotherapy (RT) with chemotherapy (CT), sequential administration seems to be superior to concomitant administration, because simultaneous use enhances intensively normal tissue damage. In sequential administration, interruption of CT during RT causes growth of distant metastases. So, alternating scheme of RT and CT is proposed and evaluated clinically. Hypoxic cell sensitizers including well-known misonidazole and PLDR inhibitors (Ara-A etc.) are promising in radiotherapy. They should be used intermittently two or three times during RT in order to avoid neurotoxicity of misonidazole. (author) 70 refs

  14. Xerostomia induced by radiotherapy

    Directory of Open Access Journals (Sweden)

    Alimi D

    2015-08-01

    Full Text Available David Alimi Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USAWe read with great interest the excellent review on xerostomia induced by radiotherapy, by Pinna et al.1 The authors should be congratulated for a very detailed review of the physiopathology, clinical symptoms, and therapeutic management of an extremely difficult condition. Although we agree that the use of anticholinergic medication represents treatment, it requires the patient to have residual salivary gland function. Unfortunately, it is well established that in most cases radiotherapy destroys most of the salivary gland and associated salivary secretions.     

  15. Anti-proton tune measurements for the Fall 1995 accelerator studies

    Energy Technology Data Exchange (ETDEWEB)

    Marriner, john; /Fermilab

    1996-04-01

    A system to measure the tunes of a single antiproton (or proton) bunch was built and has been commissioned. The system achieved high sensitivity with a novel closed-orbit suppression system. The use of high bandwidth directional pickpus and kickers in conjunction with precise timing gates enabled the measurement of the tune of a single bunch.

  16. Closing in on mass-degenerate dark matter scenarios with antiprotons and direct detection

    International Nuclear Information System (INIS)

    Over the last years both cosmic-ray antiproton measurements and direct dark matter searches have proved particularly effective in constraining the nature of dark matter candidates. The present work focusses on these two types of constraints in a minimal framework which features a Majorana fermion as the dark matter particle and a scalar that mediates the coupling to quarks. Considering a wide range of coupling schemes, we derive antiproton and direct detection constraints using the latest data and paying close attention to astrophysical and nuclear uncertainties. Both signals are strongly enhanced in the presence of degenerate dark matter and scalar masses, but we show that the effect is especially dramatic in direct detection. Accordingly, the latest direct detection limits take the lead over antiprotons. We find that antiproton and direct detection data set stringent lower limits on the mass splitting, reaching 19% at a 300 GeV dark matter mass for a unity coupling. Interestingly, these limits are orthogonal to ongoing collider searches at the Large Hadron Collider, making it feasible to close in on degenerate dark matter scenarios within the next years

  17. Antiproton-nucleus interactions at 5 to 9 GeV/c

    International Nuclear Information System (INIS)

    Antiproton beams of 5, 7 and 9 GeV/c were used to interact with C, Al, Cu, Sn and Pb nuclear targets. Charged particle multiplicity distributions, strange particle production cross sections and rapidity distributions were measured. The charged particle multiplicities are reported in this paper. (orig.)

  18. Status Report for Experiment AD-4/ACE Biological Effectiveness of Antiproton Annihilation

    CERN Document Server

    Holzscheiter, M H; Angelopoulos, Angelo; Bassler, Niels; Beyer, Gerd; Currell, Fred; De Marco, John; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Kavanagh, Joy; Iwamoto, Kei; Jäkel, Oliver; Kantemiris, Ioannis; Knudsen, Helge; Kovacevic, Sandra; McBride, Bill; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen; Ratib, Osman; Schettino, Giuseppe; Timson, David; Singers-Sørensen, Brita; Solberg, Timothy; Vranjes, Sanja; Wouters, Brad

    2009-01-01

    Status report for experiment AD-4/ACE showing recent progress in RBE measurements for V79 Chinese Hamster cells irradiated with antiprotons. Also discussed are initial test experiments using the H2AX assay to study DNA damage to cells and initial experiments using liquid ionization chambers.

  19. Real time imaging of stopping distributions in biological targets for antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Sellner, Stefan; Boll, Rebecca; Tegami, Sara [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Welsch, Carsten P. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Cockcroft Institute, University of Liverpool (United Kingdom); Holzscheiter, Michael H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); University of New Mexico, Albuquerque (United States)

    2010-07-01

    Antiprotons are interesting particles that have special properties when used in possible cancer particle therapy. They behave almost the same as protons in the entrance channel but deposit additional annihilation energy when they come to rest in the Bragg peak region. Thus, the number of antiprotons can be reduced while still delivering the same target dose to the tumor. Healthy tissue in the entrance channel is finally less harmed compared to protons which is a ultimate goal for good cancer treatment. Additionally, annihilation energy partially goes into the creation of new particles, especially pions. They exit the body mostly non-interacting and can be detected with an external detector, enabling a real time supervision of the irradiation process. This is currently not possible in any particle treatment method. In our contribution we present model calculations for a low-cost real time detector setup and compare these to results from the recent experiment carried out with the Antiproton Cell Experiment (ACE) Collaboration at the Antiproton Decelerator (AD) at CERN as well as develop improved set-ups for future experiments.

  20. Measurement of 0.25-3.2 GeV antiprotons in the cosmic radiation

    DEFF Research Database (Denmark)

    Mitchell, J.W.; Barbier, L.M.; Christian, E.R.; Krizmanic, J.F.; Krombel, K.; Ormes, J.F.; Streitmatter, R.E.; Labrador, A.W.; Davis, A.J.; Mewaldt, R.A.; Schindler, S.M.; Golden, R.L.; Stochaj, S.J.; Webber, W.R.; Menn, W.; Hof, M.; Reimer, O.; Simon, M.; Rasmussen, Ib Lundgaard

    1996-01-01

    The balloon-borne Isotope Matter-Antimatter Experiment (IMAX) was flown from Lynn Lake, Manitoba, Canada on 16-17 July 1992. Using velocity and magnetic rigidity to determine mass, we have directly measured the abundances of cosmic ray antiprotons and protons in the energy range from 0.25 to 3.2 Ge...

  1. S142 set-up to detect X-ray from antiproton-proton atoms (protonium).

    CERN Multimedia

    1978-01-01

    This experiment was designed by the Daresbury-Mainz-TRIUMF Collaboration and was located in the m14 partially separated antiproton beam in the PS South Hall. It used a gaseous hydrogen target, 1 m long, surrounded by a ring of proportional counters, surrounded in turn by a ring of 36 scintillators strips to aid in the annihilation product identification. Ugo Gastaldi (centre)

  2. Can a Higgs portal Dark Matter be compatible with the anti-proton cosmic-ray?

    International Nuclear Information System (INIS)

    Recent direct detection experiments of Dark Matter (DM), CoGeNT and DAMA implicate a light DM of a few GeV. Such a light DM would generate a large amount of anti-proton since suppression for anti-proton flux from DM annihilation is ineffective. We discuss whether a light dark matter with mass of 5-15 GeV, which is especially in favor of the recent experiments reported by CoGeNT, is compatible with the anti-proton no excess in the cosmic-ray. In view of the direct detection of DM and no anti-proton excess in the cosmic-ray both, we show that a Dirac DM is favored than a scalar one since there is no s-wave of the annihilation cross section for the Dirac DM. A large elastic cross section for direct detection can be obtained through the additional light Higgs exchange. We show an allowed region that simultaneously satisfies the DM relic density, the elastic cross section favored by CoGeNT and also the constraint of HLZZ coupling of the light Higgs boson by LEP.

  3. Closing in on mass-degenerate dark matter scenarios with antiprotons and direct detection

    Energy Technology Data Exchange (ETDEWEB)

    Garny, Mathias [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan [Technische Univ. Muenchen, Garching (Germany). Physik-Department

    2012-07-15

    Over the last years both cosmic-ray antiproton measurements and direct dark matter searches have proved particularly effective in constraining the nature of dark matter candidates. The present work focusses on these two types of constraints in a minimal framework which features a Majorana fermion as the dark matter particle and a scalar that mediates the coupling to quarks. Considering a wide range of coupling schemes, we derive antiproton and direct detection constraints using the latest data and paying close attention to astrophysical and nuclear uncertainties. Both signals are strongly enhanced in the presence of degenerate dark matter and scalar masses, but we show that the effect is especially dramatic in direct detection. Accordingly, the latest direct detection limits take the lead over antiprotons. We find that antiproton and direct detection data set stringent lower limits on the mass splitting, reaching 19% at a 300 GeV dark matter mass for a unity coupling. Interestingly, these limits are orthogonal to ongoing collider searches at the Large Hadron Collider, making it feasible to close in on degenerate dark matter scenarios within the next years.

  4. A new method to measure the gravitational acceleration of the antiproton at very low energies

    International Nuclear Information System (INIS)

    A new possible method to measure in lab the gravitational acceleration ''g'' of the antiproton is presented assuming that very low energy particles can be used. A schematic lay-out is described and preliminary results on ''g'' obtained by a simple simulation are given. The features of the method and its possible experimental problems are discussed

  5. About Peripheral Artery Disease (PAD)

    Science.gov (United States)

    ... Tools & Resources Stroke More About Peripheral Artery Disease (PAD) Updated:Mar 23,2016 Peripheral artery disease (PAD) ... critical regions of the body. Quick Facts about PAD View an illustration of PAD The most common ...

  6. Peripheral Neuropathy and Agent Orange

    Science.gov (United States)

    ... Enter ZIP code here Peripheral Neuropathy and Agent Orange VA presumes Veterans' early-onset peripheral neuropathy is related to their exposure to Agent Orange or other herbicides during service when the disease ...

  7. Advances of Precise Radiotherapy for Lung Cancer

    Directory of Open Access Journals (Sweden)

    Xin WANG

    2011-11-01

    Full Text Available At present lung tumor radiation therapy has entered the accurate radiotherapy era. Precise radiotherapy includes intensity modulated radiotherapy (IMRT, image-guided radiotherapy (IGRT and stereotactic body radiotherapy (SBRT. During the process of implementing precise radiotherapy, these problems should be fully considered to ensure executing precise radiotherapy accurately: patient positioning, controlling of the lung tumor motion, selecting of image techniques, PTV margin, dose prescription and reporting, arrangement of beams, controlling of dose volume and treatment delivering.

  8. Peripheral neuropathy in Lyme borreliosis

    OpenAIRE

    Kindstrand, Eva

    1999-01-01

    Tick-transmitted Lyme borreliosis (LB) is frequently associated with manifestations from the peripheral nervous system. One aim of the thesis was to describe the relationship between peripheral neuropathy and LB by prospective studies of a) LB in some defined neurological conditions with peripheral nerve engagement and b) peripheral neuropathy in the late dermatological LB manifestation acrodermatitis chronica atrophicans (ACA). A second aim was to evaluate the effect of ant...

  9. Erythropoietin and radiotherapy; Erythropoietine et radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Le Fur, E.; Albarghach, M.N.; Pradier, O. [CHU de Morvan, Dept. de radiotherapie, 29 - Brest (France)

    2010-01-15

    Erythropoietin (E.P.O.) is a glycoprotein hormone. This hormone is a growth factor for red blood cells precursors in the bone marrow. The decrease of oxygen partial pressure, a reduced number of erythrocytes caused by bleeding or excessive destruction, or increased tissues oxygen requirements lead to increased secretion of E.P.O.. Its action takes place on bone marrow erythroblastic cells through specific receptors. E.P.O. stimulates the proliferation of red cell precursors stem cells in the bone marrow, thus increasing their production in one to two weeks. The effectiveness of E.P.O. at increasing haemoglobin and improving patients quality of life has been demonstrated by several studies. However, its use in radiotherapy remains controversial. While tumour hypoxia caused by anaemia is a factor of radio resistance and thus a source of local failure, tumour expression of E.P.O. receptors presents a significant risk for tumour progression and neo-angiogenesis, which would be increased during the administration of E.P.O.. The purpose of this article is to answer the question: is there a place for E.P.O. in combination with radiotherapy in the management of cancer?

  10. Can we explain AMS-02 antiproton and positron excesses simultaneously by nearby supernovae without pulsars nor dark matter?

    CERN Document Server

    Kohri, Kazunori; Fujita, Yutaka; Yamazaki, Ryo

    2015-01-01

    We explain the excess of the antiproton fraction recently reported by the AMS-02 experiment by considering collisions between cosmic-ray protons accelerated by a local supernova remnant (SNR) and the surrounding dense cloud. The same "pp collisions" provide the right branching ratio to fit the observed positron excess simultaneously without a fine tuning. The supernova happened in relatively lower metalicity than the major cosmic-ray sources. The cutoff energy of electrons marks the supernova age of ~10^{5} years, while the antiproton excess may extend to higher energy. Both antiproton and positron fluxes are completely consistent with our predictions in Fujita, Kohri, Yamazaki and Ioka (2009).

  11. Study of the anti-hydrogen atom and ion formation in the collisions antiproton-positronium

    International Nuclear Information System (INIS)

    The future CERN experiment called GBAR intends to measure the gravitational acceleration of antimatter on Earth using cold (neV) anti-hydrogen atoms undergoing a free fall. The experiment scheme first needs to cool anti-hydrogen positive ions, obtained thanks to two consecutive reactions occurring when an antiproton beam collides with a dense positronium cloud.The present thesis studies these two reactions in order to optimise the production of the anti-ions. The total cross sections of both reactions have been computed in the framework of a perturbation theory model (Continuum Distorted Wave - Final State), in the range 0 to 30 keV antiproton kinetic energy; several excited states of positronium have been investigated. These cross sections have then been integrated to a simulation of the interaction zone where antiprotons collide with positronium; the aim is to find the optimal experimental parameters for GBAR. The results suggest that the 2P, 3D or, to a lower extend, 1S states of positronium should be used, respectively with 2, less than 1 or 6 keV antiprotons. The importance of using short pulses of antiprotons has been underlined; the positronium will have to be confined in a tube of 20 mm length and 1 mm diameter. In the prospect of exciting the 1S-3D two-photon transition in positronium at 410 nm, a pulsed laser system had already been designed. It consists in the frequency doubling of an 820 nm pulsed titanium-sapphire laser. The last part of the thesis has been dedicated to the realisation of this laser system, which delivers short pulses (9 ns) of 4 mJ energy at 820 nm. (author)

  12. Quality indicators in radiotherapy

    International Nuclear Information System (INIS)

    Background and purpose: There is a widespread and increasing tendency to develop hospital performance indicators in the field of accreditation/certification systems and quality benchmarking. A study has been undertaken to develop a set of performance indicators for a typical radiotherapy Centre and to evaluate their ability to provide a continuous quality improvement. Materials and methods: A working group consisting of radiation oncologists, medical physicists and radiation technologists under the coordination of experts in health technology assessment has elaborated a set of general indicators able to monitor performances and the quality level of a typical radiotherapy Centre. The work has been carried out through four steps: a preliminary set of indicators was selected; data on these indicators were collected in a number of Italian radiotherapy Centres and medical physics Services; problems in collection and analysis of data were discussed; a final set of indicators was developed. Results: A final set of 13 indicators is here presented. They concern general structural and/or operational features, health physics activities and accuracy and technical complexity of the treatment. Conclusions: The indicators tested in a few Italian Centres of radiotherapy and medical physics Services are now ready to be utilized by a larger community

  13. Bowel disease after radiotherapy

    International Nuclear Information System (INIS)

    The clinical presentation, operative findings and outcome in 40 patients who required surgery for bowel disease after radiotherapy are presented. The type of presentation varied according to the time after radiotherapy. In the first month, many patients had a proctitis but none required surgery. Five patients were operated on within one month, 2 for radiation-induced acute ileitis and 3 for exacerbations of pre-existing disease (diverticular disease 2, ulcerative colitis 1). The commonest time of presentation was between 3 and 18 months after radiotherapy, when 20 patients needed surgery for bowel disease caused by radiation-induced local ischaemia. Twelve of these patients had chronic perforation, 6 had severe rectal bleeding and 2 had painful anorectal ulceration. Fifteen patients presented between 2 and 24 years after radiotherapy, usually with incomplete intestinal obstruction due to a fibrous stricture, but 2 patients had rectal carcinoma. Wide resection of the involved bowel was the principal method of treatment but any anastomosis was protected by a proximal defunctioning stoma. There was no operative mortality but 10 patients have died subsequently. The danger of dismissing these patients as having incurable malignancy is stressed because, although the condition is infrequent, it is usually amenable to adequate surgery. (author)

  14. Nanoparticle-guided radiotherapy

    DEFF Research Database (Denmark)

    2012-01-01

    The present invention relates to a method and nano-sized particles for image guided radiotherapy (IGRT) of a target tissue. More specifically, the invention relates to nano-sized particles comprising X-ray-imaging contrast agents in solid form with the ability to block x-rays, allowing for simult...

  15. Radiotherapy treatment planning

    International Nuclear Information System (INIS)

    A teaching text on external beam radiotherapy treatment planning is presented. Chapters are included on machines, radiation units, the physics of a single radiation field, the multiple-field isodose curve pattern, electron beam therapy, manual addition of isodose curves and dose calculation methods. (U.K.)

  16. [Ganglia of peripheral nerves].

    Science.gov (United States)

    Tatagiba, M; Penkert, G; Samii, M

    1993-01-01

    The authors present two different types of ganglion affecting the peripheral nerves: extraneural and intraneural ganglion. Compression of peripheral nerves by articular ganglions is well known. The surgical management involves the complete removal of the lesion with preservation of most nerve fascicles. Intraneural ganglion is an uncommon lesion which affects the nerve diffusely. The nerve fascicles are usually intimately involved between the cysts, making complete removal of all cysts impossible. There is no agreement about the best surgical management to be applied in these cases. Two possibilities are available: opening of the epineural sheath lengthwise and pressing out the lesion; or resection of the affected part of the nerve and performing a nerve reconstruction. While in case of extraneural ganglion the postoperative clinical evolution is very favourable, only long follow up studies will reveal in case of intraneural ganglion the best surgical approach. PMID:8128785

  17. An intraosseous malignant peripheral nerve sheath tumor of the lumbar spine without neurofibromatosis: Case report and review of the literature

    OpenAIRE

    SUZUKI, KAYO; YASUDA, TAKETOSHI; HORI, TAKESHI; Watanabe, Kenta; KANAMORI, MASAHIKO; Kimura, Tomoatsu

    2014-01-01

    A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a case of the lumbar spine in a patient without NF1 is reported in the present study, with a review of the intraosseous MPNST literature. A 45-year-old female presented with a 1-mo...

  18. Painful peripheral neuropathy

    OpenAIRE

    Sun, Bo; Xu-sheng HUANG

    2013-01-01

    Painful peripheral neuropathy (PPN) is characterized by neuropathic pain (NP), which is accompanied by dysfunction of motor, sensory and autonomic nervous system. It always involves small nerve fibers, including A δ and C fibers. PPN can be classified into two types according to etiology: hereditary and acquired. Pain of PPN can manifest as spontaneous pain and stimulus-evoked pain (allodynia, hyperalgesia and hyperpathia). The manifestation of typical cases is length-dependent, which firstly...

  19. Peripheral Realism Revisited

    Directory of Open Access Journals (Sweden)

    Luis Schenoni

    2016-01-01

    Full Text Available Abstract In this article we summarize the precepts of Peripheral Realism, its place in the intellectual history of International Relations Theory, its contributions to interpreting Latin American international politics and its insights for the future. After revising the intellectual merits and tenets of the theory in the four initial sections, we show how it predicted the behavior of Latin American states under unipolarity. Finally, we review its implications for a world where China may hold economic primacy.

  20. Peripheral Realism Revisited

    OpenAIRE

    Luis Schenoni; Carlos Escudé

    2016-01-01

    Abstract In this article we summarize the precepts of Peripheral Realism, its place in the intellectual history of International Relations Theory, its contributions to interpreting Latin American international politics and its insights for the future. After revising the intellectual merits and tenets of the theory in the four initial sections, we show how it predicted the behavior of Latin American states under unipolarity. Finally, we review its implications for a world where China may hold ...

  1. Quality assurance in radiotherapy

    International Nuclear Information System (INIS)

    Good radiotherapy results and safety of treatment require the radiation to be optimally applied to a specified target area and the correct dose. According to international recommendations, the average uncertainty in therapeutic dose should not exceed 5%. The need for high precision in therapeutic dose requires quality assurance covering the entire radiotherapy process. Besides the physical and technical characteristics of the therapy equipment, quality assurance must include all radiotherapy equipment and procedures that are significant for the correct magnitude and precision of application of the therapeutic dose. The duties and responsibilities pertaining to various stages of treatment must also be precisely defined. These requirements may be best implemented through a quality system. The general requirements for supervision and quality assurance of medical radiation apparatus are prescribed in section 40 of the Radiation Act (592/1991, amendment 1142/1998) and in sections 18 and 32 of the Decree of the Ministry of Social Affairs and Health on the medical use of radiation (423/2000). Guide ST 2.2 imposes requirements on structural radiation shielding of radiotherapy equipment and the premises in which it is used, and on warning and safety arrangements. Guide ST 1.1 sets out the general safety principles for radiation practices and regulatory control procedure for the use of radiation. Guide ST 1.6 provides general requirements for operational measures in the use of radiation. This Guide sets out the duties of responsible parties (the party running a radiation practice) in respect of arranging and maintaining radiotherapy quality assurance. The principles set out in this Guide and Guide ST 6.3 may be applied to radionuclide therapy

  2. Experimental determination of the complete spin structure for anti-proton + proton -> anti-\\Lambda + \\Lambda at anti-proton beam momentum of 1.637 GeV/c

    CERN Document Server

    Paschke, K D; Berdoz, A; Franklin, G B; Khaustov, P; Meyer, C A; Bradtke, C; Gehring, R; Görtz, S; Harmsen, J; Meier, A; Meyer, W; Radtke, E; Reicherz, G; Dutz, H; Plückthun, M; Schoch, B; Dennert, H; Eyrich, W; Hauffe, J; Metzger, A; Moosburger, M; Stinzing, F; Wirth, S; Fischer, H; Franz, J; Heinsius, F H; Kriegler, E; Schmitt, H; Bunker, B; Hertzog, D; Jones, T; Tayloe, R; Bröders, R; Geyer, R; Kilian, K; Oelert, W; Röhrich, K; Sachs, K; Sefzick, T; Bassalleck, B; Eilerts, S; Fields, D E; Kingsberry, P; Lowe, J; Stotzer, R; Johansson, T; Pomp, S; Wirth, St.

    2006-01-01

    The reaction anti-proton + proton -> anti-\\Lambda + \\Lambda -> anti-proton + \\pi^+ + proton + \\pi^- has been measured with high statistics at anti-proton beam momentum of 1.637 GeV/c. The use of a transversely-polarized frozen-spin target combined with the self-analyzing property of \\Lambda/anti-\\Lambda decay allows access to unprecedented information on the spin structure of the interaction. The most general spin-scattering matrix can be written in terms of eleven real parameters for each bin of scattering angle, each of these parameters is determined with reasonable precision. From these results all conceivable spin-correlations are determined with inherent self-consistency. Good agreement is found with the few previously existing measurements of spin observables in anti-proton + proton -> anti-\\Lambda + \\Lambda near this energy. Existing theoretical models do not give good predictions for those spin-observables that had not been previously measured.

  3. Malignant peripheral nerve sheeth tumors (MPNST) - case report

    International Nuclear Information System (INIS)

    Malignant peripheral nerve sheath tumours (MPNST) are a rare entity accounting for 5%-10% f soft-tissue sarcomas. They mostly arise de novo, especially in patients suffering from neurofibromatosis. MPNST mostly arise in the trunk (50%), followed by the extremities (30%) and the head and neck region (20%). Distant metastases are common (40%-80%) and they are most frequently found in the lung and liver. Less common locations are: bone, soft tissue, adrenal glands, brain, ovaries and kidneys. The main treatment is wide surgical excision, which is reported as paramount to local control with adjuvant radiotherapy and brachytherapy. (authors)

  4. The measurement of antiproton-proton total cross sections and small-angle elastic scattering at low momentum

    International Nuclear Information System (INIS)

    In this thesis two low-momentum antiproton-proton (anti pp) experiments are described. The first one is a set of 24 high statistics anti pp total cross section measurements as a function of the incoming antiproton momentum between p=388 MeV/c and p=599 MeV/c. These measurements simultaneously yield the charge exchange cross section (anti pp → anti nn). The second one comprises two high statistics anti pp small-angle elastic scattering measurements at p=233 MeV/c and p=272 MeV/c. The measurements were carried out using the high quality antiproton beam extracted from the Low Energy Antiproton Ring (LEAR) at CERN. The physics motivation for these experiments is a search for anti pp resonances or bound states on one hand, and a detailed study of the anti pp interaction on the other hand. (orig.)

  5. Branching ratios and correlations in antiproton-proton annihilations at 1.6GeV/c

    International Nuclear Information System (INIS)

    The preliminary results on branching ratios and correlations, obtained from the antiproton-proton annihilation experiment in Gargamelle at 1.6GeV/c, are compared with the predictions of two statistical models and of a thermodynamical model

  6. Radiotherapy of bronco-pulmonary cancer; Radiotherapie des cancers brochopulmonaires

    Energy Technology Data Exchange (ETDEWEB)

    Bourry, N.; Millardet, C.; Lapeyre, M.; Verrelle, P.; Gross, E.; Champeaux-Orange, E.; Lahbabi, K.; Galland, S.; Chomy, F.; Lagarde, P.; Blanchard, P

    2007-11-15

    Six oral communications as follow: tomography by positron emission with {sup 18}F-FDG and target volume determination in the non at small cells bronchi cancers: interest and limit; adjuvant radiotherapy in the non at small cells pulmonary cancers; pulmonary stereotaxic radiotherapy; the chemoradiotherapy of locally evolved bronco-pulmonary cancers; the mesothelioma: place of radiotherapy; predictive factors of the toxicity and the care of complications of thorax irradiation. (N.C.)

  7. Atomic approaches in metastable antiprotonic helium atoms. REPLY to 'analysis of the lifetimes and fractions of antiprotons trapped in metastable antiprotonic-helium states' by I. Shimamura and M. Kimura

    International Nuclear Information System (INIS)

    In the present note the authors clarify the purpose of YO and complement its essential points, thus showing that the criticisms of SK are inappropriate. The paper YO [1] was aimed at discussing some new aspects related to the metastability of hadronic helium atoms which had been discovered when negative kaons [2], negative pions [3] and antiprotons [4] were stopped in liquid helium. The delayed fraction, time spectrum shape and lifetimes were the observables. Further experimental studies are in progress [5], and as of today there is no successful explanation for these interesting phenomena. So, YO tried to give brief and rather qualitative estimates for the observations in an intuitive way, considering only the leading terms. The following problems are discussed in as simple a manner as possible, starting from the exotic-atom viewpoints of Condo [6] and Russell [7]: i)the atomic core polarization effect, ii)the structure and radiative lifetimes, iii)the non-statistical distribution of the angular momentum and an estimate of the delayed fraction, and iv)the isotope effect, though the title represents only i). To respond to the comments of SK, it is important to consider the correspondence between the atomic approach and the molecular approach for the metastable antiprotonic helium atom of Condo-Russell. We therefore begin this note with a discussion of this aspect. (author)

  8. [Chemotherapy induced peripheral neuropathy].

    Science.gov (United States)

    Kolak, Agnieszka; Starosławska, Elzbieta; Kubiatowski, Tomasz; Kieszko, Dariusz; Cisek, Paweł; Patyra, Krzysztof Ireneusz; Surdyka, Dariusz; Mocarska, Agnieszka; Burdan, Franciszek

    2013-11-01

    Modern cancer therapy prolongs patients life but commonly increases incidence of treatment-related complications. One of such adverse effect is a neurotoxicity, which usually manifestates as peripheral neuropathies (CIPN), characterised by various sensory (tingling, numbness, pain), motor (foot and hands drop, fastening buttons difficulties) and autonomic (constipation, arythmia) abnormalities as well as pain. Despite of intensive epidemiological and clinical studies, standardized diagnostic criteria and methods of the neuropathy prevention and treatment have not been fully established. The most commonly used form of treatment is symptomatic therapy, including anticonvulsant and antidepressant drugs. Proper education of patients and their families of symptoms and neuropathy consequences is desirable to reduce anxiety and stress. PMID:24575651

  9. External audit in radiotherapy dosimetry

    International Nuclear Information System (INIS)

    Quality audit forms an essential part of any comprehensive quality assurance programme. This is true in radiotherapy generally and in specific areas such as radiotherapy dosimetry. Quality audit can independently test the effectiveness of the quality system and in so doing can identify problem areas and minimize their possible consequences. Some general points concerning quality audit applied to radiotherapy are followed by specific discussion of its practical role in radiotherapy dosimetry, following its evolution from dosimetric intercomparison exercises to routine measurement-based on-going audit in the various developing audit networks both in the UK and internationally. Specific examples of methods and results are given from some of these, including the Scottish+ audit group. Quality audit in radiotherapy dosimetry is now well proven and participation by individual centres is strongly recommended. Similar audit approaches are to be encouraged in other areas of the radiotherapy process. (author)

  10. Radiotherapy of hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Gauwerky, F.

    1982-10-11

    The findings about the regular, spontaneous and complete regression of cavernous skin hemangiomas occurring in infants and those findings about the damaging effects due to ionising radiation - here particularly local growth disturbances - led to the development of very cautious diagnostic methods and to a considerate individual dosage and radiotherapy, which always takes into consideration the spontaneous regression tendency of the hemangiomas. However, a function-impairing localisation at the orifices, fulminant macrosomia, tendency to hemorrhages and poly-infection with superficial ulceration and even thrombopenic syndromes of the Kasabach-Merritt type may become necessary, urgent and also vital indications for a particular radiotherapy. For the sake of the patients, irradiation methods, which do not provoke any risk of radiation hazards, have to be preserved and applied in practice. Certainly further research and the nosologic nature of hemangiomas is required. A general non-treatment of hemangiomas is refused.

  11. Nutrition and radiotherapy

    International Nuclear Information System (INIS)

    Full text: Radiation is a common method of treating large tumours, however one of the major problems in radiation therapy is the severe side effects that may limit its efficacy. Utilising nutrients can assist in the control of these side effects which will greatly enhance the quality of life of the patient plus improve the effectiveness of the radiation. Another controversial point regarding radiation and nutrition is the concurrent use of antioxidants and radiotherapy. The science literature is in agreement that supplementing with antioxidants after radiation is essential. In addition, most studies now show that antioxidants do not interfere with the efficacy of radiotherapy. These issues and suggestions for nutrients to assist during and after radiation will be discussed

  12. Radiotherapy for aggressive fibromatosis

    International Nuclear Information System (INIS)

    Purpose/Objective: To evaluate local control with radiotherapy for aggressive fibromatosis. Materials and Methods: Fifty-three patients with histologically confirmed aggressive fibromatosis were treated with radiotherapy at the University of Florida between March 1975 and June 1992. The minimum length of follow-up was 2 years; 88% of patients had follow-up for at least 5 years. Thirty-nine patients had lesions in an extremity and 14 patients had lesions in the trunk. Twenty-nine patients were treated for gross disease. Patients were treated with total doses between 35 Gy and 70 Gy; 83% of patients received 50 Gy to 60 Gy. Results: Local control was achieved in 23 of 29 patients (79%) treated for postoperative microscopic residual disease. Local control was achieved in 21 of 24 patients (88%) treated for gross disease; gross disease was controlled in 8 of 8 patients with previously untreated lesions, and in 13 of 16 patients treated for postoperative gross residual and recurrent disease. Overall, aggressive fibromatosis was locally controlled in 83% of treated patients. All 9 treatment failures occurred with extremity lesions 4 to 68 months after initiation of treatment. Of the 9 recurrences, 4 were out-of-field, 3 were in-field, and 4 occurred at the margin of the irradiated field. Salvage was successful in 8 of 9 patients in whom salvage was attempted with surgery alone or combined with postoperative radiotherapy. A functional limb was maintained in 38 of 39 patients with extremity or limb girdle lesions. The most serious complication of treatment was pathologic fracture, which occurred in 3 of 53 treated patients; all 3 fractures healed with conservative management. Conclusion: Radiotherapy is a valuable adjunct to surgery in the management of aggressive fibromatosis and can be used alone in patients with unresectable or inoperable disease

  13. Conformal radiotherapy: a glossary

    International Nuclear Information System (INIS)

    Most of the concepts and terms related to conformal radiotherapy were produced by English-speaking authors and eventually validated by international groups of experts, whose working language was also English. Therefore, a significant part of this literature is poorly accessible to the French-speaking radiation oncology community. The present paper gathers the 'official' definitions already published in French, along with propositions for the remaining terms which should be submitted to a more formal and representative validation process. (author)

  14. DICOM in Radiotherapy

    OpenAIRE

    A. Nikfarjam; E Ganjalikhan Hakemi; E. Negahbani; MR. Khajeaminian

    2007-01-01

    Noticeable development in achieving data from patients is acquired by means of designing a system that connects these systems: imaging, archive and monitoring systems. When several imaging devices work based on DICOM standard; they can connect to each other without any interface. There are many applications for DICOM standard in radiotherapy; however its main usage is in imaging. It has other applications such as RT Structure Set, RT Dose, RT Plan and RT Brachy Treatment. "nNow DICOM is ...

  15. Xerostomia induced by radiotherapy

    OpenAIRE

    Alimi, David

    2015-01-01

    David Alimi Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USAWe read with great interest the excellent review on xerostomia induced by radiotherapy, by Pinna et al.1 The authors should be congratulated for a very detailed review of the physiopathology, clinical symptoms, and therapeutic management of an extremely difficult condition. Although we agree that the use of anticholinergic medication represents treatment, it requires the patient to have resi...

  16. Peripheral MR angiography

    International Nuclear Information System (INIS)

    Atherosclerotic disease of the lower extremities is a common disorder in western society. Its debilitating nature calls for accurate diagnosis and treatment. The gold standard for diagnosing this disease by depiction of vessel morphology is X-ray angiography (either conventional or digital subtraction angiography). However, the invasive nature of this technique and the possible harmful effects of iodinated contrast agents have led to the idea that non-invasive MR angiography might be a good alternative for acquiring information about vessel morphology. Most extensively studied was time-of-flight MR angiography. Although first results with this technique were encouraging, it is now apparent that time-of-flight MR angiography is hampered by the virtue of which it exists, since blood flow not only generates vessel-to-background contrast, but is also the cause of disturbing artifacts. However, with the introduction of minimally invasive contrast-enhanced MR angiography, using gadolinium chelates to reduce the T1 of blood, image quality has improved dramatically. Moreover, using contrast-enhanced MR angiography, high-resolution three-dimensional data about the entire peripheral vascular tree can be obtained within several minutes, which might make MR angiography a true competitor of X-ray angiography as a diagnostic tool in the clinical work-up of a patient with complaints of peripheral atherosclerosis. The purpose of this article is to explain working mechanisms and usefulness of both time-of-flight and contrast-enhanced MR angiography. (orig.)

  17. Peripheral MR angiography

    Energy Technology Data Exchange (ETDEWEB)

    Ho, K.Y.J.A.M.; Leiner, T.; Haan, M.W. de; Engelshoven, J.M.A. van [University Hospital Maastricht (AZM) (Netherlands). Dept. of Radiology

    1999-07-01

    Atherosclerotic disease of the lower extremities is a common disorder in western society. Its debilitating nature calls for accurate diagnosis and treatment. The gold standard for diagnosing this disease by depiction of vessel morphology is X-ray angiography (either conventional or digital subtraction angiography). However, the invasive nature of this technique and the possible harmful effects of iodinated contrast agents have led to the idea that non-invasive MR angiography might be a good alternative for acquiring information about vessel morphology. Most extensively studied was time-of-flight MR angiography. Although first results with this technique were encouraging, it is now apparent that time-of-flight MR angiography is hampered by the virtue of which it exists, since blood flow not only generates vessel-to-background contrast, but is also the cause of disturbing artifacts. However, with the introduction of minimally invasive contrast-enhanced MR angiography, using gadolinium chelates to reduce the T1 of blood, image quality has improved dramatically. Moreover, using contrast-enhanced MR angiography, high-resolution three-dimensional data about the entire peripheral vascular tree can be obtained within several minutes, which might make MR angiography a true competitor of X-ray angiography as a diagnostic tool in the clinical work-up of a patient with complaints of peripheral atherosclerosis. The purpose of this article is to explain working mechanisms and usefulness of both time-of-flight and contrast-enhanced MR angiography. (orig.)

  18. Antiproton-proton Annihilation Into Two Mesons: The Role Of Relativistic Distortion

    CERN Document Server

    El-Bennich, B O

    2004-01-01

    The more than a decade old data on differential cross sections and analyzing powers in antiproton-proton annihilation into two pions (or two kaons), measured at the Low Energy Antiproton Ring (LEAR) of CERN, have stimulated several theoretical investigations. A characteristic feature of the data are the large variations of the scattering observables as a function of the scattering angle and of the laboratory energy already below 100 MeV. Amplitude analyzes reproduce the data with few partial waves (J ≤ 4) and one concludes that the annihilation process is very short- ranged and of the order of the nucleon size. Nonetheless, early models, using either baryonic or quark degrees of freedom, give rise to an even shorter antibaryon-baryon interaction failing to produce substantial higher (J ≥ 2) partial wave amplitudes and consequently to adequately describe the LEAR data. In this thesis, we systematically consider improvements within the framework of quark-line diagrams. We first derive various quar...

  19. Double excitation of He and H- by fast proton and anti-proton impact

    International Nuclear Information System (INIS)

    Theoretical investigation has been made on double excitation processes of He and H- by fast proton and anti-proton impact in the MeV/u-energy region. The cross sections are calculated by use of both the close-coupling and the perturbation expansion methods, and the wave functions of target atoms are generated based on the hyperspherical coordinate method. The excitation to the 2p21De state of H- by anti-proton impact is dominant by about three times in comparison with that by proton impact at the incident energy of 0.1 MeV/u. The spectral shape of an ejected electron from the 2s2p 1po state of H- at the incident energy of 1.5 MeV/u is consistent with the line profile of the H- photodetachment observed by Bryant et al

  20. Suppression of propagating TE modes in the FNAL antiproton source stochastic beam cooling system

    International Nuclear Information System (INIS)

    A method of attenuating the propagation of waveguide modes in the stochastic cooling array beam pipes to be utilized in the accumulator and debuncher rings of the Fermilab antiproton source is described. The attenuation method treated involves lining the vertical walls of the beam pipes with a ferrimagnetic material. The general solution for propagation in a nonhomogeneously loaded waveguide is presented along with numerical results specific to the antiproton source beam cooling system. Also described is a broadband, automated technique for the simultaneous measurement of complex μ and epsilon developed to aid in the characterization of different ferrite materials. Permittivity and permeability data for a typical ferrite are presented along with a discussion of the effects of these parameters on waveguide mode attenuation in the ferrite lined beam pipes

  1. Suppression of propagating TE modes in the fnal antiproton source stochastic beam cooling system

    International Nuclear Information System (INIS)

    A method of attenuating the propagation of waveguide modes in the stochastic cooling array beam pipes to be utilized in the accumulator and debuncher rings of the Fermilab antiproton source is described. The attenuation method treated involves lining the vertical walls of the beam pipes with a ferrimagnetic material. The general solution for propagation in a nonhomogeneously loaded waveguide is presented along with numerical results specific to the antiproton source beam cooling system. Also described is a broadband, automated technique for the simultaneous measurement of complex μ and epsilon developed to aid in the characterization of different ferrite materials. Permittivity and permeability data for a typical ferrite is presented along with a discussion of the effects of these parameters on waveguide mode attenuation in the ferrite lined beam pipes

  2. Investigation of silicon sensors for their use as antiproton annihilation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Pacifico, N., E-mail: nicola.pacifico@cern.ch [University of Bergen, Institute of Physics and Technology, Allégaten 55, 5007 Bergen (Norway); Aghion, S. [Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Milano, Via Celoria 16, 20133 Milano (Italy); Ahlén, O. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Belov, A.S. [Institute for Nuclear Research of the Russian Academy of Sciences, Moscow 117312 (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering, Via Branze 38, 25133 Brescia (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Pavia, Via Agostino Bassi 6, 27100 Pavia (Italy); Bräunig, P. [Kirchhoff Institute for Physics, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Department of Physics, University of Trento, via Sommarive 14, 38123 Povo, Trento (Italy); INFN-TIFPA, via Sommarive 14, 38123 Povo, Trento (Italy); Burghart, G. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Cabaret, L. [Laboratoire Aimé Cotton, CNRS, Université Paris Sud, ENS Cachan, Bâtiment 505, Campus d' Orsay, 91405 Orsay Cedex (France); Caccia, M. [University of Insubria, Dipartimento di Scienza ed Alta Tecnologia, via Valleggio 11, Como (Italy); Canali, C. [University of Zurich, Physics Institute, Winterthurerstrasse 190, 8057 Zurich (Switzerland); Caravita, R. [Istituto Nazionale di Fisica Nucleare, Sez. di Genova, Via Dodecaneso 33, 16146 Genova (Italy); University of Genoa, Department of Physics, Via Dodecaneso 33, 16146 Genova (Italy); Castelli, F. [University of Milano, Department of Physics, Via Celoria 16, 20133 Milano (Italy); and others

    2014-11-21

    We present here a new application of silicon sensors aimed at the direct detection of antinucleons annihilations taking place inside the sensor's volume. Such detectors are interesting particularly for the measurement of antimatter properties and will be used as part of the gravity measurement module in the AEg{sup ¯}IS experiment at the CERN Antiproton Decelerator. One of the goals of the AEg{sup ¯}IS experiment is to measure the gravitational acceleration of antihydrogen with 1% precision. Three different silicon sensor geometries have been tested with an antiproton beam to investigate their properties as annihilation detection devices: strip planar, 3D pixels and monolithic pixel planar. In all cases we were successfully detecting annihilations taking place in the sensor and we were able to make a first characterization of the clusters and tracks.

  3. Anti- and Hypermatter Research at the Facility for Antiproton and Ion Research FAIR

    Science.gov (United States)

    Steinheimer, J.; Xu, Z.; Rau, P.; Sturm, C.; Stöcker, H.

    2013-07-01

    Within the next six years, the Facility for Antiproton and Ion Research (FAIR) is built adjacent to the existing accelerator complex of the GSI Helmholtz Center for Heavy Ion Research at Darmstadt, Germany. Thus, the current research goals and the technical possibilities are substantially expanded. With its worldwide unique accelerator and experimental facilities, FAIR will provide a wide range of unprecedented fore-front research in the fields of hadron, nuclear, atomic, plasma physics and applied sciences which are summarized in this article. As an example this article presents research efforts on strangeness at FAIR using heavy ion collisions, exotic nuclei from fragmentation and antiprotons to tackle various topics in this area. In particular, the creation of hypernuclei, metastable exotic multi-hypernuclear objects (MEMOs) and antimatter is investigated.

  4. A Cryogenic Current Comparator for the Low Energy Antiproton Facilities at CERN

    CERN Document Server

    Fernandes, M; Welsch, CP

    2014-01-01

    Several laboratories have shown the potential of using Superconducting QUantum Interference Device (SQUID) magnetometers together with superconductor magnetic shields to measure beam current intensities in the submicro-Ampere regime. CERN, in collaboration with GSI, Jena university and Helmholtz Institute Jena, is currently working on developing an improved version of such a current monitor for the Antiproton Decelerator (AD) and Extra Low ENergy Antiproton (ELENA) rings at CERN, aiming for better current resolution and overall system availability. This contribution will present the current design, including theoretical estimation of the current resolution; stability limits of SQUID systems and adaptation of the coupling circuit to the AD beam parameters; the analysis of thermal and mechanical cryostat modes.

  5. Ionization of helium by slow antiproton impact: total and differential cross sections

    CERN Document Server

    Borbély, S; Nagele, S; Tőkési, K; Nagy, L; Burgdörfer, J

    2014-01-01

    We theoretically investigate the single and double ionization of the He atom by antiproton impact for projectile energies ranging from $3$~keV up to $1000$~keV. We obtain accurate total cross sections by directly solving the fully correlated two-electron time-dependent Schr\\"odinger equation and by performing classical trajectory Monte-Carlo calculations. The obtained quantum-mechanical results are in excellent agreement with the available experimental data. Along with the total cross sections, we also present the first fully \\textit{ab initio} doubly differential data for single ionization at 10 and 100~keV impact energies. In these differential cross sections we identify the binary-encounter peak along with the anticusp minimum. Furthermore, we also point out the importance of the post-collisional electron-projectile interaction at low antiproton energies which significantly suppresses electron emission in the forward direction.

  6. Secondary emission monitor for keV ion and antiproton beams

    CERN Document Server

    Sosa, Alejandro; Bravin, Enrico; Harasimowciz, Janusz; Welsch, C P

    2013-01-01

    Beam profile monitoring of low intensity keV ion and antiproton beams remains a challenging task. A Sec- ondary electron Emission Monitor (SEM) has been de- signed to measure profiles of beams with intensities below 107 and energies as low as 20 keV. The monitor is based on a two stage microchannel plate (MCP) and a phosphor screen facing a CCD camera. Its modular design allows two different operational setups. In this contribution we present the design of a prototype and discuss results from measurements with antiprotons at the AEgIS experiment at CERN. This is then used for a characterization of the monitor with regard to its possible future use at different facilities.

  7. Cryogenic design of the stochastic cooling pick-ups for the CERN antiproton collector (ACOL)

    International Nuclear Information System (INIS)

    Stochastic cooling, a technique of prime importance for obtaining antiproton beams usable at high-energy colliders, requires wide-band and low-noise signal acquisition and processing. For this purpose, the CERN Antiproton Collector (ACOL), presently under construction, is equipped with six beam pick-up stations operating at cryogenic temperatures. Each station consists of a high-vacuum vessel housing two mobile arrays of pick-up electrodes, cooled to about 100 K by radiation to a surrounding thermal shield, and two preamplifiers kept below 20 K. Refrigeration is provided by a pair of two-stage Gifford-McMahon helium cryogenerators, thermally linked to the preamplifiers and to the thermal shield. The cryogenerators also cool activated charcoal cryopanels, in order to maintain a residual pressure in the vessel below 10-8 mbar. The choice of such cryogenic options is dictated by performance (steady-state and cool-down), simplicity of operation and maintenance, and high reliability

  8. Radiotherapy of adult nodal non Hodgkin`s lymphoma; Place de la radiotherapie dans le traitement des formes ganglionnaires des lymphomes non hodgkiniens de l`adulte

    Energy Technology Data Exchange (ETDEWEB)

    Gamen, G. [Centre Jean-Bernard, Clinique Victor-Hugo, 72 - Le Mans (France); Thirion, P. [Hopital Henri-Mondor, 94 - Creteil (France). Service de cancerologie

    1999-03-01

    The role of radiotherapy in the treatment of nodal non-Hodgkin`s lymphoma has been modified by the introduction of efficient chemotherapy and the development of different pathological classifications. The recommended treatment of early-stage aggressive lymphomas is primarily a combination chemotherapy. The interest of adjuvant radiotherapy remains unclear and has to be established through large prospective trials. If radiation therapy has to be delivered, the historical results of exclusive radiation therapy showed that involved-fields and a dose of 35-40 Gy (daily fraction of 1.8 Gy, 5 days a week) are the optimal schedule. The interest of radiotherapy in the treatment of advanced-stage aggressive lymphoma is yet to be proven. Further studies had to stratify localized stages according to the factors of the International Prognostic Index. For easy-stage low-grade lymphoma, radiotherapy remains the standard treatment. However, the appropriate technique to use is controversial. Involved-field irradiation at a dose of 35 Gy seems to be the optimal schedule, providing a 10 year disease-free survival rate of 50 % and no major toxicity. There is no standard indication of radiotherapy in the treatment advanced-stage low-grade lymphoma. For `new` nodal lymphoma`s types, the indication of radiotherapy cannot be established (mantle-zone lymphoma, marginal zone B-cell lymphoma) or must take into account the natural history (Burkitt`s lymphoma, peripheral T-cell lymphoma) and the sensibility to others therapeutic methods. (authors)

  9. Nucleon density in the nuclear periphery determined with antiprotonic x-rays: cadmium and tin isotopes

    OpenAIRE

    Schmidt, R.; Trzcinska, A.; Czosnyka, T.; von Egidy, T.; Gulda, K.; Hartmann, F. J.; Jastrzebski, J.; Ketzer, B.; Kisielinski, M.; Klos, B.; Kurcewicz, W.; Lubinski, P.; Napiorkowski, P.; Pienkowski, L.; Smolanczuk, R.

    2002-01-01

    The x-ray cascade from antiprotonic atoms was studied for 106Cd, 116Cd, 112Sn, 116Sn, 120Sn, and 124Sn. Widths and shifts of the levels due to strong interaction were deduced. Isotopic effects in the Cd and Sn isotopes are clearly seen. The results are used to investigate the nucleon density in the nuclear periphery. The deduced neutron distributions are compared with the results of the previously introduced radiochemical method and with HFB calculations.

  10. Strangeness production in antiproton-tantalum interactions at 4 GeV/c

    International Nuclear Information System (INIS)

    A general measure of strangeness production in antiproton-nucleus interactions is given which is unaffected by strangeness exchange reactions occurring after the initial annihilation. An intranuclear cascade model of anti p-nucleus interactions has also been developed. Both approaches are applied to data on strange particle yields and rapidity distributions obtained in 4 GeV/c anti p-Ta collisions. No evidence is seen for exotic phenomena. (orig.)

  11. Computer control of RF-manipulations in the CERN antiproton accumulator

    International Nuclear Information System (INIS)

    The CERN antiproton accumulator uses a conventional RF system for bunched beam manipulation within the ring. Several different manipulations are needed, often in close succession, so a fast, reliable and accurate method of switching between them is required. This has led to an unconventional computerized beam control system. For a desired set of beam manipulations, the computer calculates the needed voltage and frequency as functions of time, using a mathematical model of the beam and lattice. These are then loaded into function generators which subsequently operate independently of the computer. The RF system, a dual gap, ferrite loaded cavity driven by a 4CX25000 power tetrode, has three main uses: the stacking process to accumulate the antiprotons, the unstacking process to make the accumulated antiprotons available for extraction, and a variety of test and measurement purposes. Two digital function generators control voltage and frequency in the cavity. The voltage function is logarithmic and is fed into an AVC loop which contains a logarithmic detector and modulator to provide high voltage for stacking and low voltage for unstacking. The frequency function controls a 10 to 30 kHz quadrature VCO which is mixed with the output of a quadrature synthesizer producing an 1840 to 1860 kHz frequency range. RF phase and magnet noise were harmful while manipulating low emittance proton and antiproton bunches. A high-pass phase loop acquires beam cavity phase; adding AC corrections to the frequency program eliminated this problem. The cavity tune is maintained by a tuning loop acting on a DC ferrite base. Schematics are provided

  12. Neutral strange particle production in antiproton-nucleus annihilation at low energies

    International Nuclear Information System (INIS)

    The cross sections of the Λ- and KS0-meson production in antiproton annihilation on nuclei at low energies (Epbar- and K-meson rescattering, Λ production in reactions with π- and ω-mesons is also considered. It is shown that these processes ensure a significant Λ-production even in the low energy region well below the ΛΛ-bar-threshold. 18 refs.; 1 tab

  13. Shift and broadening of resonance lines of the antiprotonic helium atoms in liquid He-4

    OpenAIRE

    Adamczak, Andrzej; Bakalov, Dimitar

    2013-01-01

    The shift and broadening of the resonance lines in spectrum of the antiprotonic helium atoms $\\bar{p}\\mathrm{He}^{+}$ located in fluid and superfluid $^4$He have been calculated. The contributions to the shift and broadening from collective degrees of freedom in liquid $^4$He have been estimated using the phenomenological response function. Effects due to the interaction of $\\bar{p}\\mathrm{He}^{+}$ with a single $^4$He atom have been calculated in the quasistatic approximation using the exper...

  14. Slope analysis for elastic proton-proton and proton-antiproton scattering

    OpenAIRE

    Okorokov, V. A.

    2008-01-01

    The diffraction slope parameter is investigated for elastic proton-proton and proton-antiproton scattering based on the all available experimental data at intermediate square of momentum transfer in the main. Energy dependence of the elastic diffraction slope is approximated by various analytic functions in a model-independent fashion. The expanded standard logarithmic approximations allow to describe experimental slopes in all available energy range at qualitative level reasonably. Various f...

  15. Diffraction slopes for elastic proton-proton and proton-antiproton scattering

    OpenAIRE

    Okorokov, V. A.

    2008-01-01

    The diffraction slope parameter is investigated for elastic proton-proton and proton-antiproton scattering based on the all available experimental data at low momentum transfer values. Energy dependence of the elastic diffraction slopes is approximated by various analytic functions. The expanded "standard" logarithmic approximations allow to describe experimental slopes in all available energy range reasonably. Various approximations differ from each other both in the low energy and very high...

  16. Antiproton production in heavy-ion collisions at energies below the threshold

    International Nuclear Information System (INIS)

    In the framework of this thesis the antiproton production in heavy ion collisions at projectile energies far below the threshold for anti p production in nucleon-nucleon collisions (5.63 GeV/u) was studied. A suited detection apparature was developed and constructed at the fragment separator-magnet spectrometer at the Society for Heavy Ion Research (GSI). For the identification of the antiprotons the momentum of the particles emitted in beam direction was measured and their velocity multiple-redundantly determined by means of time-of-flight measurements and threshold Cherenkov detectors. By this way the antiprotons could be in spite of low anti p production cross sections and high production rates for lighter particles (R antip:RK--:Rπ--∼1:5*103:107) background-freely determined. By this experiment for Ne+NaF, Cu, Sn, and Bi as well ass Ni+Ni collisions at incident energies between 1.6 GeV/u and 2.0 GeV/u production cross sections for antiprotons in the momentum range between 1.0 GeV/c and 2.2 GeV/c and for kaons and pions between 0.5 GeV/c and 2.8 GeV/c were measured, in order to study the influence of collisional-system size, incident energy, and secondary-particle momentum on the production probabilities and to contribute in comparison with the prognoses of theoretical models to the explanation of the particle production mechanisms. (HSI)

  17. Transverse momentum spectra for charged particles at the CERN proton-antiproton collider

    International Nuclear Information System (INIS)

    We have measured transverse momentum spectra up to 10 GeV/c for charged particles produced centrally in proton-antiproton collisions at 540 GeV in the centre of mass at the CERN collider. Our results are compared with data at ISR energies and with the predictions of a QCD model. The charged particle spectrum shows a clear dependence on charged track multiplicity. (orig.)

  18. Drug-induced peripheral neuropathy

    DEFF Research Database (Denmark)

    Vilholm, Ole Jakob; Christensen, Alex Alban; Zedan, Ahmed;

    2014-01-01

    Peripheral neuropathy can be caused by medication, and various descriptions have been applied for this condition. In this MiniReview, the term 'drug-induced peripheral neuropathy' (DIPN) is used with the suggested definition: Damage to nerves of the peripheral nervous system caused by a chemical...... substance used in the treatment, cure, prevention or diagnosis of a disease. Optic neuropathy is included in this definition. A distinction between DIPN and other aetiologies of peripheral neuropathy is often quite difficult and thus, the aim of this MiniReview is to discuss the major agents associated with...

  19. Heavy flavour production and heavy flavour mixing at the CERN proton-antiproton collider

    International Nuclear Information System (INIS)

    In this thesis some results of the proton-antiproton-collision experiment UA1 with the CERN Super Proton-Antiproton Synchrotron are presented and interpreted. Ch. 1 contians a general introduction to the physics motivations behind the proton-antiproton-collider project, a brief description of the CERN facilities and a summary of collider and UA1 physics achievements. Furthermore the concept of studying heavy flavours via their weak decays into muons is introduced. Ch. 2 gives a brief overview of the UA1 experimental set-up, while those parts of the detector that are relevant for the analysis, presented in this thesis, is discussed in some more detail. Ch. 3 contains a short introduction to, and motivation for the use of Monte Carlo techniques in event simulations, while Ch. 4 describes the framework of the recently developed 'EUROJET' event generator. In Ch. 5 a treatment is given of the theoretical background and concepts like 'quark-mixing' and 'CP-violation' are explained, also other useful definitions and formulae are introduced on which the later analysis of the same-sign to opposite-sign dimuon ratio is built. Data collection and event reconstruction is the subject of Ch. 6, while a detailed comparison between the theoretical models and experimentally obtained distributions is given in Ch. 7. Finally, in Ch. 8 some concluding remarks are made. 182 refs.; 81 figs.; 9 tabs

  20. Unified interpretation of cosmic-ray nuclei and antiproton recent measurements

    International Nuclear Information System (INIS)

    We use our numerical code, DRAGON, to study the implications and the impact of recent CREAM and PAMELA data on our knowledge of the propagation properties of cosmic ray nuclei with energy >or similar 1 GeV/n in the Galaxy. We will show that B/C (as well as N/O and C/O) and anti p/p data (especially including recent PAMELA results) can consistently be matched within a unique diffusion-reacceleration model. The requirement that light nuclei and anti p data are both reproduced within experimental uncertainties places stringent limits on suitable propagation parameters. In particular, we find the allowed range of the diffusion coefficient spectral index to be 0.38A ≅15 kms-1) is allowed. Furthermore, we do not need to introduce any ad hoc break in the injection spectrum of primary cosmic rays. If antiproton data are not used to constrain the propagation parameters, a larger set of models is allowed. In this case, we determine which combinations of the relevant parameters maximize and minimize the antiproton flux under the condition of still fitting light nuclei data at 95% C.L. These models may then be used to constrain a possible extra antiproton component arising from astrophysical or exotic sources (e.g. dark matter annihilation or decay). (orig.)

  1. Application of high quality antiproton beam to study charmonium and exotics above DD-bar threshold

    International Nuclear Information System (INIS)

    The spectroscopy of charmonium and exotic states with hidden charm is discussed. It is a good testing tool for theories of strong interactions including QCD in both perturbative and non-perturbative regime, lattice QCD, potential models and phenomenological models. An elaborated analysis of charmonium and charmed hybrid spectrum is given, and attempts to interpret recent experimental data in the above DD-bar threshold region are considered. Experiments using antiproton beam take advantage of the intensive production of particle-antiparticle pairs in antiproton-proton annihilations. Experimental data from different collaboration are analyzed with special attention given to new states with hidden charm that were discovered recently. Some of these states can be interpreted as higher-laying S, P and D wave charmonium states. But much more data on different decay modes are needed before firmer conclusions can be made. These data can be derived directly from the experiments using high quality antiproton beam with momentum up to 15 GeV/c. (authors)

  2. Measurements of Wake-Riding Electrons in Antiproton-Carbon-Foil Collisions

    CERN Multimedia

    2002-01-01

    When a charged particle passes through dielectric media, e.g. a thin carbon foil, a ``wake'' is induced. The characteristic wake-potential shows an oscillatory behaviour, with a wavelength of about $ 2 \\pi v _{p} / \\omega _{p} _{l} $ where $ v _{p} $ is the projectile velocity and $ \\omega _{p} _{l} $ the plasmon energy of the target. This induced wake potential is superimposed on the Coulomb potential of the projectile, the latter leading to a pronounced ``cusp'' of electrons leaving the solid at $ v _{e} app v _{p} $ for positively charged projectiles in the MeV region. Correspondingly, an ``anti-cusp'' is expected for antiprotons. \\\\ \\\\ In the solid, the wake-potential leads to an attractive force on electrons, and a dynamic electronic state is predicted both for proton and antiproton projectiles. In the solid, the wake-riding electrons are travelling with the projectile speed $ v _{p} $ Upon exit of the foil, the electron released from the wake-riding state of an antiproton will suddenly find itself in th...

  3. Limits on dark matter from AMS-02 antiproton and positron fraction data

    Science.gov (United States)

    Lu, Bo-Qiang; Zong, Hong-Shi

    2016-05-01

    Herein we derive limits on dark matter annihilation cross section and lifetime using measurements of the AMS-02 antiproton ratio and positron fraction data. In deriving the limits, we consider the scenario of secondary particles accelerated in supernova remnants (SNRs), which has been argued to be able to reasonably account for the AMS-02 high-energy positron/antiproton fraction/ratio data. We parametrize the contribution of secondary particles accelerated in SNRs and then fit the observational data within the conventional cosmic ray propagation model by adopting the galprop code. We use the likelihood ratio test to determine the 95% confidence level upper limits of possible dark matter (DM) contribution to the antiproton/positron fractions measured by AMS-02. Under the assumption taken in this work, we find that our limits are stronger than that set by the Fermi-LAT gamma ray Pass 8 data observation on the dwarf spheroidal satellite galaxies. We show that the solar modulation (cosmic ray propagation) parameters can play a non-negligible role in modifying the constraints on dark matter annihilation cross section and lifetime for mχ100 GeV ), where mχ is the rest mass of dark matter particles. We also find that constrains on DM parameters from AMS-02 data would become more stringent when the solar modulation is weak. Using these results, we also put limits on the effective field theory of dark matter.

  4. Cosmic positron and antiproton constraints on the gauge-Higgs Dark Matter

    CERN Document Server

    Cheung, Kingman; Tseng, Po-Yan

    2010-01-01

    We calculate the cosmic ray positron and antiproton spectra of a gauge-Higgs dark matter candidate in a warped five-dimensional $SO(5) \\times U(1)$ gauge-Higgs unification model. The stability of the gauge-Higgs boson is guaranteed by the H parity under which only the Higgs boson is odd at low energy. The 4-point vertices of HHW^+W^- and HHZZ, allowed by H parity conservation, have the same magnitude as in the standard model, which yields efficient annihilation rate for $m_H > m_W$. The most dominant annihilation channel is $H H \\to W^+ W^-$ followed by the subsequent decays of the $W$ bosons into positrons or quarks, which undergo fragmentation into antiproton. Comparing with the observed positron and antiproton spectra with the PAMALA and Fermi/LAT, we found that the Higgs boson mass cannot be larger than 90 GeV, in order not to overrun the observations. Together with the constraint on not overclosing the Universe, the valid range of the dark matter mass is restricted to 70-90 GeV.

  5. Cosmic positron and antiproton constraints on the gauge-Higgs dark matter

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, Kingman; Song, Jeonghyeon [Division of Quantum Phases and Devices, School of Physics, Konkuk university, Seoul 143-701 (Korea, Republic of); Tseng, Po-Yan, E-mail: cheung@phys.nthu.edu.tw, E-mail: jeonghyeon.song@gmail.com, E-mail: d9722809@oz.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China)

    2010-09-01

    We calculate the cosmic ray positron and antiproton spectra of a gauge-Higgs dark matter candidate in a warped five-dimensional SO(5) × U(1) gauge-Higgs unification model. The stability of the gauge-Higgs boson is guaranteed by the H parity under which only the Higgs boson is odd at low energy. The 4-point vertices of HHW{sup +}W{sup −} and HHZZ, allowed by H parity conservation, have the same magnitude as in the standard model, which yields efficient annihilation rate for m{sub H} > m{sub W}. The most dominant annihilation channel is HH → W{sup +}W{sup −} followed by the subsequent decays of the W bosons into positrons or quarks, which undergo fragmentation into antiproton. Comparing with the observed positron and antiproton spectra with the PAMALA and Fermi/LAT, we found that the Higgs boson mass cannot be larger than 90 GeV, in order not to overrun the observations. Together with the constraint on not overclosing the Universe, the valid range of the dark matter mass is restricted to 70–90 GeV.

  6. Cosmic positron and antiproton constraints on the gauge-Higgs dark matter

    International Nuclear Information System (INIS)

    We calculate the cosmic ray positron and antiproton spectra of a gauge-Higgs dark matter candidate in a warped five-dimensional SO(5) × U(1) gauge-Higgs unification model. The stability of the gauge-Higgs boson is guaranteed by the H parity under which only the Higgs boson is odd at low energy. The 4-point vertices of HHW+W− and HHZZ, allowed by H parity conservation, have the same magnitude as in the standard model, which yields efficient annihilation rate for mH > mW. The most dominant annihilation channel is HH → W+W− followed by the subsequent decays of the W bosons into positrons or quarks, which undergo fragmentation into antiproton. Comparing with the observed positron and antiproton spectra with the PAMALA and Fermi/LAT, we found that the Higgs boson mass cannot be larger than 90 GeV, in order not to overrun the observations. Together with the constraint on not overclosing the Universe, the valid range of the dark matter mass is restricted to 70–90 GeV

  7. Measurement of asymmetries and differential cross sections in antiproton-proton elastic scattering at momenta between 497 and 1550 MeV/c

    International Nuclear Information System (INIS)

    An intermediate energy antiproton proton (anti pp) elastic scattering experiment is described. The data comprise a set of 15 measurements of the differential cross section and the asymmetry between 497 and 1550 MeV/c antiproton momentum. The measurements were carried out using the high quality antiproton beam provided by the Low Energy Antiproton Ring (LEAR) at CERN. A conventional polarized target was used, consisting of pentanol. The motivation for the measurements is the study of the anti pp interaction by providing data on the spin observable Aon in a momentum range where it has never been measured before. 56 refs.; 55 figs.; 40 tabs

  8. A new calculation of the cosmic-ray antiproton spectrum in the Galaxy and heliospheric modulation effects on this spectrum using a drift plus wavy current sheet model

    International Nuclear Information System (INIS)

    The expected interstellar antiproton spectrum arising from cosmic-ray interactions in the Galaxy is recalculated, and the modulation of both antiprotons and protons is calculated using a two-dimensional modulation model incorporating gradient and curvature drifts and a wavy current sheet as well as the usual diffusion, convection, and energy-loss effects. Significant differences in the antiproton/proton ratio for different solar magnetic field polarities are predicted as well as a 'low-energy' component for antiprotons below about 1 GeV. 28 refs

  9. A new calculation of the cosmic-ray antiproton spectrum in the Galaxy and heliospheric modulation effects on this spectrum using a drift plus wavy current sheet model

    Energy Technology Data Exchange (ETDEWEB)

    Webber, W.R.; Potgieter, M.S. (New Hampshire Univ., Durham (USA); Potchefstroom University for Christian Higher Education (South Africa))

    1989-09-01

    The expected interstellar antiproton spectrum arising from cosmic-ray interactions in the Galaxy is recalculated, and the modulation of both antiprotons and protons is calculated using a two-dimensional modulation model incorporating gradient and curvature drifts and a wavy current sheet as well as the usual diffusion, convection, and energy-loss effects. Significant differences in the antiproton/proton ratio for different solar magnetic field polarities are predicted as well as a 'low-energy' component for antiprotons below about 1 GeV. 28 refs.

  10. Radiotherapy of presenile spinal osteoporosis

    International Nuclear Information System (INIS)

    Painfull conditions of presenile spinal osteoporosis may no longer respond to medication or physical therapy. Analgesic radiotherapy coupled with mild physical therapy and if necessary supported by orthopedic measures frequently results in pain relief and physical stability. Fifty-two cases of osteoporosis and osteoporotic spinal fractures illustrate how better longterm results are achieved by increasing the customary dosage and speeding up radiotherapy. (orig.)

  11. Conceptual Design Report. Antiproton - Proton Collider Upgrade 20 GeV Rings. Technical Components and Civil Construction May, 1988

    Energy Technology Data Exchange (ETDEWEB)

    None

    1988-05-01

    This report contains a description of the design and cost estimate of two new 20 GeV rings which will be required to support the upgrade of the Fermilab Collider with a luminosity goal of 5x10 31 cm-2s-1. The new rings include an antiproton post-accumulator, denoted the Antiproton Super Booster (ASB), and a proton post-booster, denoted the Proton Super Booster (PSB). The siting of the rings is shown in Figure I-1. Both rings are capable of operation at 20 GeV, eliminating the need for ever again injecting beam into the Main Ring below transition, and significantly enhancing Main Ring performance. The Antiproton Super Booster is designed to accept and accumulate up to 4x1012 antiprotons from the existing Antiproton Accumulator, and deliver them to the Main Ring at 20 GeV for acceleration and injection into the Collider. It is also designed to accept diluted antiprotons from the Main Ring at 20 GeV for recooling. The PSB accepts 8.9 GeV protons from the existing Booster and accelerates them to 20 GeV for injection into the Main Ring. The PSB is designed to operate at 5 Hz. The siting shown in Figure I-1 has the attractive feature that it removes all Main Ring injection hardware from the AO straight section, opening the possibility of installing a third proton-antiproton interaction region in the Tevatron Collider.

  12. Radiotherapy for eyelid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Saika, Kazumi [Yokohama City Univ. (Japan). School of Medicine

    2001-05-01

    Some studies on radiotherapy for eyelid cancer have been reported, but the optimal radiation doses for different histological types and tumor sizes have not been detailed. So I studied the optimal radiation doses in radiotherapy for eyelid cancer. The patients were fourteen and histological diagnoses were made on the basis of biopsies or surgery before radiotherapy. Surgical cut margins were positive in 10 cases. In 5 of these cases, tumors were visible. There were 9 sebaceous adenocarcinomas (SAC), 4 squamous cell carcinomas (SCC), and 1 basal cell carcinoma (BCC). In 13 of 14 cases, radiation was applied to eyelids in which tumor-surgical cut margin distances were 3 mm or less. The eyeballs were covered with lead or tungsten shields, and the eyelids were irradiated with a total dose of 50 to 66.6 Gy. In 5 cases, radiation was applied prophylactically for ipsilateral pre-auricle lymph node areas. 11 of 13 cases were locally controlled. I gave greater radiation doses for SAC than for SCC or BCC. I also gave greater doses for in visible tumors than for invisible ones. In the acute phase dermatitis, inflammation of the cornea, conjunctivitis, etc. occurred but they were mild. Later reactions were decreased cilia, dry eye, inflammation of cornea, conjunctivitis, discomfort of the scar, etc. Cataracts were also seen, but they were of senile origen. Because 81.8% of the tumors were controlled, this radiation method was useful with salvage therapies to select an optimal radiation dose according to the differences among histological types and tumor sizes. 60% of visible tumors were also controlled so I think that radical therapy using radiation alone is possible. (author)

  13. Deriving stress from peripheral physiology

    NARCIS (Netherlands)

    De Vries, J.J.G.; Van Dooren, M.; Van Beek, W.H.M.; Dijk, E.O.; Ouwerkerk, M.; Westerink, J.H.D.

    2012-01-01

    Objectives We set up an experiment to explore whether peripheral physiological parameters are capable of reflecting human (short term) stress. Methods For 30 participants, we measured peripheral physiology (SCR, ECG, RSP, TEMP, EMG) during several tasks (3 relaxing, 3 physically stressful, 3 mental

  14. Progress of peripheral nerve repair

    Institute of Scientific and Technical Information of China (English)

    陈峥嵘

    2002-01-01

    Study on repair of peripheral nerve injury has been proceeding over a long period of time. With the use of microsurgery technique since 1960s,the quality of nerve repair has been greatly improved. In the past 40 years, with the continuous increase of surgical repair methods, more progress has been made on the basic research of peripheral nerve repair.

  15. Peripheral Polyneuropathy and Mefloquine Prophylaxis

    OpenAIRE

    Chester, Alexander C.; Sandroni, Paola

    2011-01-01

    We describe a case of a woman who developed a peripheral polyneuropathy shortly after completing 4 weekly doses of mefloquine hydrochloride (250 mg) malaria prophylaxis. Although mefloquine-related central nervous system neuropathy is well described in the literature, peripheral polyneuropathy similar to this case has been documented only once before, to our knowledge.

  16. Progesterone and peripheral nerve regeneration

    Institute of Scientific and Technical Information of China (English)

    Fei Fan; Haichao Li; Yuwei Wang; Yanglin Zheng; Lianjun Jia; Zhihui Wang

    2006-01-01

    OBJECTIVE: To explore the effect of progesterone on peripheral nerve regeneration.DATA SOURCES: An online search of Medline and OVID databases was under taken to identify articles about progesterone and peripheral nerve regeneration published in English between January 1990 and June 2004 by using the keywords of "peripheral nerve, injury, progesterone, regeneration".STUDY SELECTION: The data were primarily screened, those correlated with progesterone and peripheral nerve regeneration were involved, and their original articles were further searched, the repetitive studies or reviews were excluded.DATA EXTRACTION: Totally 59 articles about progesterone and peripheral nerve regeneration were collected, and 26 of them were involved, the other 33 excluded ones were the repetitive studies or reviews.DATA SYNTHESIS: Recent researches found that certain amount of progesterone could be synthetized in peripheral nervous system, and the expression of progesterone receptor could be found in sensory neurons and Schwann cells. After combined with the receptor, endogenous and exogenous progesterone can accelerate the formation of peripheral nerve myelin sheath, also promote the axonal regeneration.CONCLUSION: Progesterone plays a role in protecting neurons, increasing the sensitivity of nerve tissue to nerve growth factor, and accelerating regeneration of nerve in peripheral nerve regeneration, which provides theoretical references for the treatment of demyelinated disease and nerve injury, as well as the prevention of neuroma, especially that the in vivo level of progesterone should be considered for the elderly people accompanied by neuropathy and patients with congenital luteal phase defect, which is of positive significance in guiding the treatment.

  17. Radiotherapy of benign diseases

    International Nuclear Information System (INIS)

    Still today radiotherapy is of decisive relevance for several benign diseases. The following ones are briefly described in this introductory article: 1. Certain inflammatory and degenerative diseases as furuncles in the face, acute thrombophlebitis, recurrent sudoriparous abscesses, degenerative skeletal diseases, cervical syndrome and others; 2. rheumatic joint diseases; 3. Bechterew's disease; 4. primary presenile osteoporosis; 5. synringomyelia; 6. endocrine ophthalmopathy; 7. hypertrophic processes of the connective tissue; 8. hemangiomas. A detailed discussion and a profit-risk analysis is provided in the individual chapters of the magazine. (MG)

  18. Contrast-enhanced peripheral MRA

    DEFF Research Database (Denmark)

    Nielsen, Yousef W; Thomsen, Henrik S

    2012-01-01

    In the last decade contrast-enhanced magnetic resonance angiography (CE-MRA) has gained wide acceptance as a valuable tool in the diagnostic work-up of patients with peripheral arterial disease. This review presents current concepts in peripheral CE-MRA with emphasis on MRI technique and contrast......-state MRA. Gadolinium(Gd)-based contrast agents are used for CE-MRA of the peripheral arteries. Extracellular Gd agents have a pharmacokinetic profile similar to iodinated contrast media. Accordingly, these agents are employed for first-pass MRA. Blood-pool Gd-based agents are characterized by prolonged...... agents. Peripheral CE-MRA is defined as an MR angiogram of the arteries from the aortic bifurcation to the feet. Advantages of CE-MRA include minimal invasiveness and lack of ionizing radiation. The basic technique employed for peripheral CE-MRA is the bolus-chase method. With this method a paramagnetic...

  19. HIV peripheral neuropathy.

    Science.gov (United States)

    Gabbai, Alberto Alain; Castelo, Adauto; Oliveira, Acary Souza Bulle

    2013-01-01

    Peripheral neuropathies are the most common neurological manifestations occurring in HIV-infected individuals. Distal symmetrical sensory neuropathy is the most common form encountered today and is one of the few that are specific to HIV infection or its treatment. The wide variety of other neuropathies is akin to the neuropathies seen in the general population and should be managed accordingly. In the pre-ART era, neuropathies were categorized according to the CD4 count and HIV viral load. In the early stages of HIV infection when CD4 count is high, the inflammatory demyelinating neuropathies predominate and in the late stages with the decline of CD4 count opportunistic infection-related neuropathies prevail. That scenario has changed with the present almost universal use of ART (antiretroviral therapy). Hence, HIV-associated peripheral neuropathies are better classified according to their clinical presentations: distal symmetrical polyneuropathy, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), mononeuropathies, mononeuropathies multiplex and cranial neuropathies, autonomic neuropathy, lumbosacral polyradiculomyelopathy, and amyotrophic lateral sclerosis (ALS)-like motor neuropathy. Treated with ART, HIV-infected individuals are living longer and are at a higher risk of metabolic and age-related complications; moreover they are also prone to the potentially neurotoxic effects of ART. There are no epidemiological data regarding the incidence and prevalence of the peripheral neuropathies. In the pre-ART era, most data were from case reports, series of patients, and pooled autopsy data. At that time the histopathological evidence of neuropathies in autopsy series was almost 100%. In large prospective cohorts presently being evaluated, it has been found that 57% of HIV-infected individuals have distal symmetrical sensory neuropathy and 38% have neuropathic pain. It is now clear that

  20. Breast cancer radiotherapy: controversies and prospectives

    Institute of Scientific and Technical Information of China (English)

    YU Jin-ming; WANG Yong-sheng

    2008-01-01

    @@ Despite consensus on breast cancer radiotherapy, there are still some controversies over post-mastectomy radiotherapy (PMRT) in patients with 1-3 positive lymph nodes, accelerated partial breast irradiation (APBI), appropriate sequence of radiotherapy, chemotherapy and hormonal treatment, and radiotherapy after preoperative systemic therapy.

  1. Radiotherapy in Kimura's Disease

    International Nuclear Information System (INIS)

    Kimura's disease is a rare disorder which predominantly involves the head and neck region can cause eosinophilia in peripheral blood. It has been treated with steroids, surgical excision, irradiation, cryotherapy, and laser. The sessions have a tendency to recur after steroid and surgery. We reviewed 2 patients with Kimura's disease who recurred, because they were resistant steroid therapy and surgery, and treated successfully conventional radiation therapy

  2. Transverse tomography and radiotherapy

    International Nuclear Information System (INIS)

    This study was intended to delineate the indications for radiotherapy treatment-planning with the help of computerized axial tomography (C.T.) and transverse analog tomography (T.A.T.). Radiotherapy localisation procedures with the conventional method (simulator), with the CT-scanner and with the transverse analog tomograph (T.A.T., Simtomix, Oldelft) were compared. As criterium for evaluation differences in reconstruction drawing based on these methods were used. A certain method was judged ''superior'' to another if the delineation of the target volume was more accurate, if a better impression was gained of the site of (for irradiation) organs at risk, or if the localisation could only be performed with that method. The selected group of patients consisted of 120 patients for whom a reconstruction drawing in the transverse plane was made according to the treatment philosophy. In this group CT-assisted localisation was judged on 68 occasions superior to the conventional method. In a number of cases it was found that a ''standard'' change in a standard target volume, on the base of augmented anatomical knowledge, made the conventional method sufficient. The use of CT-scanner for treatment planning was estimated. For ca. 270/1000 new patients a CT-scan is helpful (diagnostic scan), for 140 of them the scan is necessary (planning scan). The quality of the anatomical information obtained with the T.A.T. does not yet fall within acceptable limits, but progress has been made. (Auth.)

  3. Imaging in radiotherapy

    International Nuclear Information System (INIS)

    The diagnostic methodologies used for the radiotherapy planning have undergone great developments in the last 30 years. Since the 1980s, after the introduction of the CT scanner, the modality for the planning moved beyond the planar 2D assessment to approach a real and more realistic volumetric 3D definition. Consequently the dose distribution, previously obtained by means of an overly simple approximation, became increasingly complex, better tailoring the true shape of the tumour. The final therapeutic improvement has been obtained by a parallel increase in the complexity of the irradiating units: the Linacs for therapy have, in fact, been equipped with a full accessory set capable to modulate the fluence (IMRT) and to check the correct target position continuously during the therapy session (IMRT-IGRT). The multimodal diagnostic approach, which integrates diagnostic information, from images of the patient taken with CT, NMR, PET and US, further improves the data for a biological and topological optimization of the radiotherapy plan and consequently of the dose distribution in the Planning Target Volume. Proteomic and genomic analysis will be the next step in tumour diagnosis. These methods will provide the planners with further information, for a true personalization of the treatment regimen and the assessment of the predictive essays for each tumour and each patient.

  4. Advances in radiotherapy

    International Nuclear Information System (INIS)

    Radiation therapy is in the midst of a rebirth largely driven by the use of computers for treatment planning and beam delivery. The first edge of this renaissance was the advent of three-dimensional conformal radiation therapy (3-D CRT). This was enabled by the widespread availability and utilization of three-dimensional imaging such as computed tomography and magnetic resonance scanning, themselves products of the computer revolution. For the first time this allowed radiation oncologists to segment and visualize the tumor in association with it neighboring sensitive soft-tissue structures. Software tools to visualize the beam paths through the body enabled the beam directions and beam shapes to be manually optimized. Simultaneously, improved dose calculations utilizing the CT images of the patient anatomy produced more accurate distributions of dose. The dose was delivered with custom-shaped blocks or recently collimators with multiple leaves that allow complex shaped fields to be delivered without the need for block fabrication. In the last couple of decades new treatment delivery methodologies have emerged. The first has been stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT) which is the purview of neurosurgeons (who call it SRS) as well as radiation oncologists (who usually call it SRT). SRS and SRT are premised on multiple beams focusing on one location typically with circular aperture collimators but increasingly with fields shaped by multi-leaved collimators. Often only a single treatment session (the usual for SRS) is used when the treatment volume is small, but for larger lesions several treatment sessions, or fractions, are used (most often for SRT) to allow for normal tissue repair. The new equipment market for SRS and SRT is about 10% of the total for radiation therapy. Intensity-modulated radiation therapy (IMRT) is the latest treatment methodology and its adoption has been extremely rapid, particularly in the United States. IMRT uses

  5. Clinical studies of effect of Jinshi Granule on reducing the toxic radiotherapy reaction in nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Objective: To study the effects of Jinshi Granule (JSG) on decreasing the toxic reaction of radiotherapy in nasopharyngeal carcinoma (NPC) patients in order to search for an effective method and medicines. Methods: Altogether 90 patients with NPC treated by radical radiotherapy were divided into three groups at random. Each group consisted of 30 patients who all received radiotherapy. Patients of the 1st treatment group were treated by JSG, the 2nd treatment group by Biyan Qingdu Ji (BQJ), and the control group by placebo. Results: (1) In JSG group, the effective rate, the rate of completing radiotherapy, the enhancing and stabilization rate of quality of life were 93.33%, 96.67% and 90.00%, respectively, which were all higher than those in other groups (P < 0.05, P < 0.01). (2) The degree of the toxic reaction syndromes in the JSG group was lower than that in other two groups and the stabilization of peripheral hemogram was much better (P < 0.05, P < 0.01). Conclusion: These data show that JSG has significant effects on reducing the toxic reaction of radiotherapy to NPC and combining it with radiotherapy is an effective method in treating NPC

  6. Influence of surgical treatment and radiotherapy of the advanced intraoral cancers on complete blood count, body mass index, liver enzymes and leukocyte CD64 expression:

    OpenAIRE

    Didanovič, Vojislav; Dovšak, Tadej; Ihan Hren, Nataša; Ihan, Alojz; Kansky, Andrej

    2009-01-01

    Background. The aim of our study was to evaluate the influence of the surgery and radiotherapy of the advanced oral squamous cell carcinoma on the complete blood count, body mass index (BMI), acute inflam-matory response, liver enzymes and expression of the CD64 index on leukocytes in the peripheral blood. Patients and method. Venous blood was obtained from 16 patients with advanced oral squamous cell carcinomas treated with radical surgery and external beam radiotherapy. Blood samples were c...

  7. Peripheral Auditory Mechanisms

    CERN Document Server

    Hall, J; Hubbard, A; Neely, S; Tubis, A

    1986-01-01

    How weIl can we model experimental observations of the peripheral auditory system'? What theoretical predictions can we make that might be tested'? It was with these questions in mind that we organized the 1985 Mechanics of Hearing Workshop, to bring together auditory researchers to compare models with experimental observations. Tbe workshop forum was inspired by the very successful 1983 Mechanics of Hearing Workshop in Delft [1]. Boston University was chosen as the site of our meeting because of the Boston area's role as a center for hearing research in this country. We made a special effort at this meeting to attract students from around the world, because without students this field will not progress. Financial support for the workshop was provided in part by grant BNS- 8412878 from the National Science Foundation. Modeling is a traditional strategy in science and plays an important role in the scientific method. Models are the bridge between theory and experiment. Tbey test the assumptions made in experim...

  8. Chest wall desmoid tumours treated with definitive radiotherapy: a plan comparison of 3D conformal radiotherapy, intensity-modulated radiotherapy and volumetric-modulated arc radiotherapy

    OpenAIRE

    Liu, Jia; Ng, Diana; Lee, James; Stalley, Paul; Hong, Angela

    2016-01-01

    Purpose Definitive radiotherapy is often used for chest wall desmoid tumours due to size or anatomical location. The delivery of radiotherapy is challenging due to the large size and constraints of normal surrounding structures. We compared the dosimetry of 3D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc radiotherapy (VMAT) to evaluate the best treatment option. Methods and materials Ten consecutive patients with inoperable chest wall de...

  9. Radiotherapy in a public health

    International Nuclear Information System (INIS)

    The aim of our publication is to evaluate the state of radiotherapy, its role and place in oncology and in the public health system, in order to plan necessities. The cost and economical effectiveness are objectives of the current evaluation. Radiotherapy is strongly dependant of introducing new technologies and the need of gross capital investments. However, their relative cost is reduced due to their long-term use. Because of the serious delay of Bulgaria from the world standards in radiotherapy, the analysis is based on the data published in the scientific literature. The main tendencies and ideas for development are based on the analysis of The Swedish Council on Technology Assessment in Health Care (SBU) and the ESTRO QUARTS project. We use Swedish model for estimating the expenses, having in mind the conditions in Bulgaria (salary, management, patient cares). The main conclusions are: 1) Radiotherapy is basic curative and palliative method in oncology; 2) Bulgarian radiotherapy is at one of the last places in Europe (therapeutic units are 30 years old average, despite their recommended exploitation of 12-20 years); 3) In contradiction to the world tendencies delay grows during the last 10 years; 4) In countries with low or average GDP radiotherapy should be prioritized, due to its low cost in comparison to the other treatment methods in oncology; 5) The need of radiotherapy will continue to grow, this necessitate not only replacement of the old machines but increasing their number 3 times during the next few years; 6) It is necessary to form a modern radiotherapy centers, equipped with at least two compatible units, based on the currently existing radiotherapy departments. (authors)

  10. Radiotherapy gel dosimetry

    International Nuclear Information System (INIS)

    In radiotherapy, the primary objective is to deliver a prescribed dose of radiation to a tumour or lesion within a patient while minimising the dose delivered to the surrounding healthy tissue. Traditional radiotherapy treatments usually involve simple external or internal irradiations of a tumour. External irradiations are normally achieved in the clinic with photon or electron beams produced by high energy linear accelerators. The photon or electron beams are collimated into regular shapes as they emerge from the treatment head of the unit which is supported by a gantry that can be rotated isocentrically to any position. A discrete number of photon or electron beams with different angles of incidence that intersect at the iso-centre are used to produce a region of high dose around the tumour volume (positioned at the iso-centre). Internal irradiations are normally achieved in the clinic by implanting radioactive sources in and around the tumour or lesion. Such irradiations are characterised by very high doses local to the tumour. Radioactive sources are also used to prevent post-angioplasty restenosis by inserting sources into arteries. Usually when treating a tumour, a compromise is made between tumour control and complications arising from normal tissue damage. One measure of this compromise, the therapeutic ratio, is defined as the radiation dose producing complications in 50% of patients divided by the dose providing tumour control in 50% of the patients. The therapeutic ratio depends on the radiobiological characteristics of the cancerous tissue and surrounding healthy tissues and on the radiation dose distribution achieved by the radiotherapy treatment. It is generally believed that the therapeutic ratio can be minimised by optimising the conformation of the radiation dose distribution to the target volume. This is difficult with traditional radiotherapy techniques since they do not produce dose distributions that adequately cover tumour volumes of complex

  11. Adaptive Motion Compensation in Radiotherapy

    CERN Document Server

    Murphy, Martin J

    2011-01-01

    External-beam radiotherapy has long been challenged by the simple fact that patients can (and do) move during the delivery of radiation. Recent advances in imaging and beam delivery technologies have made the solution--adapting delivery to natural movement--a practical reality. Adaptive Motion Compensation in Radiotherapy provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy. This authoritative book discusses: Each of the contributing elements of a motion-adaptive system, including target detection and tracking, beam adaptation, and pati

  12. Development of targeted radiotherapy systems

    International Nuclear Information System (INIS)

    Conventional or external beam radiotherapy, has been a viable alternative for cancer treatment. Although this technique is effective, its use is limited if the patient has multiple malignant lesions (metastases). An alternative approach is based on the design of radiopharmaceuticals that, to be administered in the patient, are directed specifically toward the target cell producing a selective radiation delivery. This treatment is known as targeted radiotherapy. We have summarized and discussed some results related to our investigations on the development of targeted radiotherapy systems, including aspects of internal dosimetry

  13. Mutant frequency of radiotherapy technicians appears to be associated with recent dose of ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Messing, K.; Ferraris, J.; Bradley, W.E.; Swartz, J.; Seifert, A.M. (Universite du Quebec a Montreal (Canada))

    1989-10-01

    The frequency of hypoxanthine phosphoribosyl transferase (HPRT) mutants among peripheral T-lymphocytes of radiotherapy technicians primarily exposed to 60Co was measured by the T-cell cloning method. Mutant frequencies of these technicians in 1984 and 1986 were significantly higher than those of physiotherapy technicians who worked in a neighboring service, and correlated significantly with thermoluminescence dosimeter readings recorded during the 6 mo preceding mutant frequency determination. Correlations decreased when related to dose recorded over longer time intervals. HPRT mutant frequency determination in peripheral lymphocytes is a good measure of recently received biologically effective radiation dose in an occupationally exposed population.

  14. Radiotherapy in paediatric oncology

    International Nuclear Information System (INIS)

    Full text: Radiation therapy has always been one of the most powerful tools in the fight against childhood cancer. Since the middle of the last century, we have known that most paediatric tumours are exquisitely sensitive to radiation. The early application of radiotherapy alone led to the first cures of retinoblastoma, Hodgkin lymphoma, as well as certain sarcomas and brain tumours. The generous application of radiation in conjunction with chemotherapy led to further extraordinary increases in survival rates for leukemias, Wilms tumour, sarcomas, and other paediatric malignancies. Over the past 40 years, the overall cure rate for childhood cancer has climbed from 25% to 75% in the USA. With this success, however, came the knowledge that radiation can be associated with significant late effects. We now have a much better understanding of both the benefits and risks of using radiation to treat children as we seek to optimize and refine its role in curative therapy. Leukemias constitute approximately one third of paediatric cancer diagnoses and most of these patients are successfully treated with chemotherapy alone. Central nervous system (CNS) radiation is still recommended for patients at highest risk of CNS failure and total body radiation is useful for the small percentage of patients who require bone marrow transplant. Brain tumours also make up almost one-third of paediatric neoplasms and children with most kinds of brain tumours will require high dose radiotherapy. Many of the other types of paediatric tumours (Wilms, neuroblastoma, sarcomas, etc.) also require radiotherapy as part of curative treatment. There have been considerable advances in radiation technology including three dimensional planning, intensity modulated radiation therapy, and protons. Individual paediatric patients may or may not benefit from advanced technologies based on numerous patient and disease related factors. Examples will be illustrated. We must also be mindful of economic and

  15. The Angular Distribution Of Electron-positron Pairs From Exclusive Charmonium Decays In Antiproton-proton Annihilations

    CERN Document Server

    McTaggart, R J

    1998-01-01

    The angular distributions of the charmonium resonances J/ Y (3097) and Y (3686) in their exclusive decay to an electron-positron pair are studied. Experiment 835 at the Fermi National Accelerator Laboratory produced charmonium resonances by annihilating protons with antiprotons in the Fixed Target Mode of the Antiproton Accumulator: A stochastically cooled antiproton beam collides with a hydrogen gas jet, which forms clusters under the right pressure and low temperature. The charmonium decay products are detected out of a large hadronic background with the help of a segmented lead glass sampling calorimeter, which is sensitive to the high mass electron-positron charmonium decay, and a set of Cerenkov threshold detectors that provide good electron/pion separation. Several factors influence the angular distribution parameter l taken from the angular distribution, including the energy scale of the resonance, the coupling strength of the charmonium atom, and how quarks and gluons interact in the dissolution...

  16. Can we explain AMS-02 antiproton and positron excesses simultaneously by nearby supernovae without pulsars or dark matter?

    Science.gov (United States)

    Kohri, Kazunori; Ioka, Kunihito; Fujita, Yutaka; Yamazaki, Ryo

    2016-02-01

    We explain the excess of the antiproton fraction recently reported by the AMS-02 experiment by considering collisions between cosmic-ray protons accelerated by a local supernova remnant and the surrounding dense cloud. The same "pp collisions" provide the right ratio of daughter particles to fit the observed positron excess simultaneously in the natural model parameters. The supernova happened in relatively lower metallicity than the major cosmic-ray sources. The cutoff energy of electrons marks the supernova age of {˜ }105 years, while the antiproton excess may extend to higher energy. Both antiproton and positron fluxes are completely consistent with our predictions in an earlier paper [Y. Fujita et al., Phys. Rev. D 80, 063003 (2009) [arXiv:0903.5298 [astro-ph.HE

  17. Simulation studies of the beam cooling process in presence of heating effects in the Extra Low ENergy Antiproton ring (ELENA)

    International Nuclear Information System (INIS)

    The Extra Low ENergy Antiproton ring (ELENA) is a small synchrotron equipped with an electron cooler, which is currently being constructed at CERN to further decelerate antiprotons from the Antiproton Decelerator (AD) from 5.3 MeV to energies as low as 100 keV. At such low energies it is very important to carefully take contributions from electron cooling and beam heating mechanisms (e.g. on the residual gas and intrabeam scattering) into account. Detailed investigations into the ion kinetics under consideration of effects from electron cooling and heating sources have been carried out, and the equilibrium phase space dimensions of the beam have been computed, based on numerical simulations using the code BETACOOL. The goal is to provide a consistent explanation of the different physical effects acting on the beam in ELENA

  18. [Hepatic tumors and radiotherapy].

    Science.gov (United States)

    Rio, E; Mornex, F; Peiffert, D; Huertas, A

    2016-09-01

    Recent technological developments led to develop the concept of focused liver radiation therapy. We must distinguish primary and secondary tumors as the indications are restricted and must be discussed as an alternative to surgical or medical treatments. For hepatocellular carcinoma 5 to 10cm (or more), a conformational radiation with or without intensity modulation is performed. Stereotactic body radiotherapy (SBRT) is being evaluated and is increasingly proposed as an alternative to radiofrequency ablative treatment for primary or secondary tumors (typically less than 5cm). Tumor (and liver) movements induced by respiratory motions must be taken into account. Strict dosimetric criteria must be met with particular attention to the dose-volume histograms to liver and the hollow organs, including cases of SBRT. PMID:27521035

  19. Radiotherapy for bone metastases

    International Nuclear Information System (INIS)

    Between December 1986 and January 1978, 68 patients with bone metastases were analyzed to evaluate the effect of radiation for the relief of pain. The 68 patients, who had a total of 97 lesions, complained of pain caused by their bone metastasis. The good, fair, and poor responses were found to be 18%, 60%, and 22%, respectively. With reference to the primary neoplasms, the effective response rate was 73% in lung cancer, 100% in breast cancer, 75% in gastric cancer, 100% in hepatic cancer, 100% in bladder cancer, 25% in epipharyngeal cancer, and 70% in the other neoplasms. Depending on the cell types of the lung cancer, the effective response rate was 80% for small cell carcinomas, 72% for adenocarcinomas and 40% for squamous cell carcinomas. Our results suggest that radiotherapy for bone metastases is to be recommended, since the effective response rate was 78% for the relief of pain. (author)

  20. Radiotherapy in pancreatic cancer

    International Nuclear Information System (INIS)

    Purpose and approach: to summarize the current knowledge on the role of radiotherapy in the treatment of pancreatic ductal adenocarcinoma (PDAC). The results of meta-analyses, phase III-studies, and phase II-studies using chemoradiation (CRT) and chemotherapy for resectable and non-resectable PDAC are reviewed. Results and conclusion: the role of CRT is undefined in the adjuvant setting but there may be a role as additive treatment after R1 resection. Locally advanced borderline resectable tumors may shrink down and be subject to potentially curative resections. In locally advanced clearly unresectable cancers the effect of CRT as well as chemotherapy is poorly defined and the sequence of chemotherapy and CRT should be re-evaluated. Patients with PDAC should always be treated within studies to identify optimal treatment results. (orig.)

  1. Tumours following retinoblastoma radiotherapy

    International Nuclear Information System (INIS)

    Radioinduced tumours in young patients irradiated in childhood for retinoblastoma take on a particularly deadly aspect. The onset of this true clinical entity characterized by a long post-irradiation latency period induced by a dose above 6000 rads is a real tragedy. The vast majority of patients then enter into a long martyrdom ending in death. The only cure is surgical, but seldom possible. Treatment is limited to palliative radiotherapy, effective for a while, and chemiotherapy as a last resort but often difficult to prescribe. Prevention alone is the answer. The quality and reliability of the radiotherapeutic treatment depend not only on the personal talent of the radiotherapist but above all on the standard of the equipment. A strong reduction in the doses employed as well as recent technological progress improving the material, its precision and reproducibility appear already to have lowered the frequency curve of these fatal radioinduced tumours

  2. Anatomical imaging for radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Evans, Philip M [Joint Physics Department, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey SM2 5PT (United Kingdom)], E-mail: phil.evans@icr.ac.uk

    2008-06-21

    The goal of radiation therapy is to achieve maximal therapeutic benefit expressed in terms of a high probability of local control of disease with minimal side effects. Physically this often equates to the delivery of a high dose of radiation to the tumour or target region whilst maintaining an acceptably low dose to other tissues, particularly those adjacent to the target. Techniques such as intensity modulated radiotherapy (IMRT), stereotactic radiosurgery and computer planned brachytherapy provide the means to calculate the radiation dose delivery to achieve the desired dose distribution. Imaging is an essential tool in all state of the art planning and delivery techniques: (i) to enable planning of the desired treatment, (ii) to verify the treatment is delivered as planned and (iii) to follow-up treatment outcome to monitor that the treatment has had the desired effect. Clinical imaging techniques can be loosely classified into anatomic methods which measure the basic physical characteristics of tissue such as their density and biological imaging techniques which measure functional characteristics such as metabolism. In this review we consider anatomical imaging techniques. Biological imaging is considered in another article. Anatomical imaging is generally used for goals (i) and (ii) above. Computed tomography (CT) has been the mainstay of anatomical treatment planning for many years, enabling some delineation of soft tissue as well as radiation attenuation estimation for dose prediction. Magnetic resonance imaging is fast becoming widespread alongside CT, enabling superior soft-tissue visualization. Traditionally scanning for treatment planning has relied on the use of a single snapshot scan. Recent years have seen the development of techniques such as 4D CT and adaptive radiotherapy (ART). In 4D CT raw data are encoded with phase information and reconstructed to yield a set of scans detailing motion through the breathing, or cardiac, cycle. In ART a set of

  3. MRI assisted radiotherapy planning

    International Nuclear Information System (INIS)

    To obtain the optimal radiation field, an MR simulation system (MRSS) has been developed. The system consists of an MR unit, a work station and a laser marking system. Phantom study concerned geographic distortion and the total accuracy of MRSS, the former revealed the result lesser than 1 mm within 90 mm-distance between MR slices and Center of magnetic field, the latter showed maximal errors 2 mm in the field size, and 3 mm in the iso-center. This system was applied to 15 patients with intracranial or head and neck lesions and all procedures were smoothly performed. To evaluate the usefulness of MRSS, 6 radiation oncologists compared the difference between MRSS and CT simulation system in setting radiation field. The results were satisfactory especially in cases with lesions the extent of which was unclear on CT images. It was considered that this system could support the radiotherapy planning for intracranial or head and neck lesions. (author)

  4. Image guided multibeam radiotherapy

    International Nuclear Information System (INIS)

    This paper provides an outlook of the status of the first development stages for an updated design of radiotherapy conformal system based on tumor 3D images obtained as an output the last generation imaging machines as PET, CT and MR which offer a very valuable output in cancer diagnosis. Prospective evaluation of current software codes and acquisition of useful experience in surgical planning involves a multidisciplinary process as an initial and unavoidable stage to develop an expert software and user skills which assures the delivery of the radiation dose is done correctly in geometry and value in each voxel as a radiation protection basic condition. The validation of the images obtained has been done by the production of anatomical models of interest regions by rapid prototyping of the 3D segmented images and its evaluation by contrasting with the real regions during surgical procedures. (author)

  5. Image guided multibeam radiotherapy

    International Nuclear Information System (INIS)

    This paper provides an outlook of the status of the first development stages for an updated design of radiotherapy conformal system based on tumor 3D images obtained as an output the last generation imaging machines as PET, CT and MR which offer a very valuable output in cancer diagnosis. Prospective evaluation of current software codes and acquisition of useful experience in surgical planning involves a multidisciplinary process as an initial and unavoidable stage to develop an expert software and user skills which assures the delivery of the radiation dose is done correctly in geometry and value in each voxel as a radiation protection basic condition. The validation of the images obtained has been done by the production of anatomical models of interest regions by rapid proto typing of the 3D segmented images and its evaluation by contrasting with the real regions during surgical procedures. (author)

  6. Anatomical imaging for radiotherapy

    International Nuclear Information System (INIS)

    The goal of radiation therapy is to achieve maximal therapeutic benefit expressed in terms of a high probability of local control of disease with minimal side effects. Physically this often equates to the delivery of a high dose of radiation to the tumour or target region whilst maintaining an acceptably low dose to other tissues, particularly those adjacent to the target. Techniques such as intensity modulated radiotherapy (IMRT), stereotactic radiosurgery and computer planned brachytherapy provide the means to calculate the radiation dose delivery to achieve the desired dose distribution. Imaging is an essential tool in all state of the art planning and delivery techniques: (i) to enable planning of the desired treatment, (ii) to verify the treatment is delivered as planned and (iii) to follow-up treatment outcome to monitor that the treatment has had the desired effect. Clinical imaging techniques can be loosely classified into anatomic methods which measure the basic physical characteristics of tissue such as their density and biological imaging techniques which measure functional characteristics such as metabolism. In this review we consider anatomical imaging techniques. Biological imaging is considered in another article. Anatomical imaging is generally used for goals (i) and (ii) above. Computed tomography (CT) has been the mainstay of anatomical treatment planning for many years, enabling some delineation of soft tissue as well as radiation attenuation estimation for dose prediction. Magnetic resonance imaging is fast becoming widespread alongside CT, enabling superior soft-tissue visualization. Traditionally scanning for treatment planning has relied on the use of a single snapshot scan. Recent years have seen the development of techniques such as 4D CT and adaptive radiotherapy (ART). In 4D CT raw data are encoded with phase information and reconstructed to yield a set of scans detailing motion through the breathing, or cardiac, cycle. In ART a set of

  7. Quark versus hadron degrees of freedom in antiproton-proton annihilation's

    International Nuclear Information System (INIS)

    Data on antiproton-proton annihilation at rest into two mesons are presented with special emphasis on the importance of dynamical selection rules. These selection rules reduce the frequency of some annihilation rates for otherwise allowed annihilation modes by one order of magnitude. It is shown that SU(3) breaking cannot be held responsible for such large effects. This fact motivates an analysis of anti-pp branching ratios by SU(3) amplitudes. Different SU(3) coupling schemes and their interpretation are presented. A coupling scheme tracing the quark flux from the initial to the final state gives the best interpretation of the data and of the dynamical selection rules. (author)

  8. Antiproton-proton annihilations into four prongs at 7.2 GeV/c

    International Nuclear Information System (INIS)

    Annihilation reactions are described in which four charged pions and also maybe uncharged particles are produced. Data was acquired in an antiproton-proton experiment at a beam momentum of 7.2 GeV/c and 220K pictures of the CERN 2m HBC were measured. Cross sections have been determined and angular distributions of the pions and of some resonances are given. Two models that describe annihilation reactions are treated, the so called CLA model and a simple quark model. (C.F./Auth.)

  9. Measurement of (anti)deuteron and (anti)proton production in DIS at HERA

    International Nuclear Information System (INIS)

    The first observation of (anti)deuterons in deep inelastic scattering at HERA has been made with the ZEUS detector at a centre-of-mass energy of 300-318 GeV using an integrated luminosity of 120 pb-1. The measurement was performed in the central rapidity region for transverse momentum per unit of mass in the range 0.3T/M<0.7. The particle rates have been extracted and interpreted in terms of the coalescence model. The (anti)deuteron production yield is smaller than the (anti)proton yield by approximately three orders of magnitude, consistent with the world measurements. (orig.)

  10. Ring imaging Cherenkov counter of HERMES for pion, kaon, proton and anti-proton identification

    Energy Technology Data Exchange (ETDEWEB)

    Shibata, Toshi-Aki

    2014-12-01

    RICH of HERMES was built for identification of pion, kaon, proton and anti-proton in the momentum range of 2–15 GeV/c. It was a dual-radiator RICH. The radiators were aerogel and C{sub 4}F{sub 10} gas. Produced hadrons in electron–nucleon deep inelastic scattering were identified by the RICH and spin structure of the nucleon was studied by correlation between the directions of the target spin, scattered electron and produced hadrons.

  11. The FLUKA study of the secondary particles fluence in the AD-Antiproton Decelerator target area

    CERN Document Server

    Calviani, M

    2014-01-01

    In this paper we present Monte Carlo FLUKA simulations [1, 2] carried out to investigate the secondary particles fluence emerging from the antiproton production target and their spatial distribution in the AD target area. The detailed quantitative analysis has been performed for different positions along the magnet dog-leg as well as after the main collimator. These results allow tuning the position of the new beam current transformers (BCT) in the target area, in order to have a precise pulse-by-pulse evaluation of the intensity of negative particles injected in the AD-ring before the deceleration phase.

  12. Search for a light Higgs boson at the Fermilab Tevatron proton-antiproton collider

    International Nuclear Information System (INIS)

    We have searched for a light standard-model Higgs boson produced in association with an intermediate vector boson at the Fermilab proton-antiproton collider operating at a center-of-mass energy of 1.8 TeV. The search was made by looking for an excess of isolated high-transverse-momentum charged-track pairs in W and Z events. A Higgs boson with a mass mH in the intervals 2mμH2 and 846 MeV/c2HK is excluded at 90% C.L

  13. GAPS - Dark matter search with low-energy cosmic-ray antideuterons and antiprotons

    OpenAIRE

    von Doetinchem, P.; Aramaki, T.; Boggs, S.; Fuke, H.; Hailey, C. J.; Mognet, S. I.; Ong, R. A.; K. Perez; Zweerink, J.

    2015-01-01

    The GAPS experiment is foreseen to carry out a dark matter search by measuring low-energy cosmic-ray antideuterons and antiprotons with a novel detection approach. It will provide a new avenue to access a wide range of different dark matter models and masses from about 10GeV to 1TeV. The theoretically predicted antideuteron flux resulting from secondary interactions of primary cosmic rays is very low. Well-motivated theories beyond the Standard Model contain viable dark matter candidates, whi...

  14. Kickers and power supplies for the Fermilab Tevatron I antiproton source

    International Nuclear Information System (INIS)

    The Fermilab Antiproton Source Accumulator and Debuncher rings require 5 kickers in total. These range in design from conventional ferrite delay line type magnets, with ceramic beam tubes to mechanically complex shuttered kickers situated entirely in the Accumulator Ring's 10-10 torr vacuum. Power supplies are thyratron switched pulse forming networks that produce microsecond width pulses of several kiloamps with less than 30 nanoseconds rise and fall times. Kicker and power supply design requirements for field strength, vacuum, rise and fall time, timing and magnetic shielding of the stacked beam in the accumulator by the eddy current shutter will be discussed. 8 refs., 3 figs., 2 tabs

  15. Basic physics program for a low energy antiproton source in North America

    International Nuclear Information System (INIS)

    We summarize much of the important science that could be learned at a North American low energy antiproton source. It is striking that there is such a diverse and multidisciplinary program that would be amenable to exploration. Spanning the range from high energy particle physics to nuclear physics, atomic physics, and condensed matter physics, the program promises to offer many new insights into these disparate branches of science. It is abundantly clear that the scientific case for rapidly proceeding towards such a capability in North America is both alluring and strong. 38 refs., 2 tabs

  16. What do we learn from proton-antiproton diffractive scattering at the CERN colliders

    International Nuclear Information System (INIS)

    We point out that the recent proton-antiproton collision experiments at the ISR allow for the first time a comparison with proton-proton collisions and make it possible to test very general predictions based on axiomatic field theory and also to confirm certain aspects of conventional models and to eliminate certain unorthodox possibilities . We also discuss what will be the output of the measurement of total cross-sections and elastic scattering at the SPS panti p collider, and describe what might happen in the ultra-high energy limit. (orig.)

  17. Effect of static electric field on cross sections in antiproton impact ionization of atomic helium

    International Nuclear Information System (INIS)

    We report the effect of static electric fields in different geometrical features on the collisional ionization of helium atoms by antiproton. The Classical Trajectory Monte Carlo (CTMC) method with a model interaction potential has been used to simulate the differential and total ionization cross sections in antiproton–helium atom collisions in the energy range of 10–500 keV with and without electric fields. The calculated ionization cross sections are in reasonable agreement with the recently reported experimental and theoretical results. The effects of the external electric fields are seen to be quite prominent.

  18. Highlights on gamma rays, neutrinos and antiprotons from TeV Dark Matter

    Directory of Open Access Journals (Sweden)

    Gammaldi Viviana

    2016-01-01

    Full Text Available It has been shown that the gamma-ray flux observed by HESS from the J1745-290 Galactic Center source is well fitted as the secondary gamma-rays photons generated from Dark Matter annihilating into Standard Model particles in combination with a simple power law background. The neutrino flux expected from such Dark Matter source has been also analyzed. The main results of such analyses for 50 TeV Dark Matter annihilating into W+W− gauge boson and preliminary results for antiprotons are presented.

  19. Measurement of (anti)deuteron and (anti)proton production in DIS at HERA

    CERN Document Server

    Chekanov, S; Magill, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, M C K; Jechow, M; Pavel, N; Yagues-Molina, A G; Antonelli, S; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Bindi, M; Boscherini, D; Bruni, A; Bruni, G; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Sartorelli, G; Zichichi, A; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Jakob, H P; Jüngst, M; Kind, O M; Nuncio-Quiroz, A E; Paul, E; Renner, R; Samson, U; Schonberg, V; Shehzadi, R; Wlasenko, M; Brook, N H; Heath, G P; Morris, J D; Namsoo, T; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, J Y; Ma, K J; Ibrahim, Z A; Kamaluddin, B; Wan-Abdullah, W A T; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Gil, M; Olkiewicz, K; Stopa, P; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M; Suszycki, L; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Blohm, C; Bonato, A; Borras, K; Ciesielski, R; Coppola, N; Dossanov, A; Drugakov, V; Fourletova, J; Geiser, A; Gladkov, D; Göttlicher, P; Grebenyuk, J; Gregor, I; Haas, T; Hain, W; Horn, C; Huttmann, A; Kahle, B; Katkov, I I; Klein, U; Kötz, U; Kowalski, H; Lobodzinska, E; Löhr, B; Mankel, R; Melzer-Pellmann, I A; Miglioranzi, S; Montanari, A; Notz, D; Rinaldi, L; Roloff, P; Rubinsky, I; Santamarta, R; Schneekloth, U; Spiridonov, A; Stadie, H; Szuba, D; Szuba, J; Theedt, T; Wolf, G; Wrona, K; Youngman, C; Zeuner, W; Lohmann, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, P G; Bamberger, A; Dobur, D; Karstens, F; Vlasov, N N; Bussey, P J; Doyle, A T; Dunne, W; Ferrando, J; Forrest, M; Saxon, D H; Skillicorn, I O; Gialas, I; Papageorgiu, K; Gosau, T; Holm, U; Klanner, R; Lohrmann, E; Salehi, H; Schleper, P; Schörner-Sadenius, T; Sztuk, J; Wichmann, K; Wick, K; Foudas, C; Fry, C; Long, K R; Tapper, A D; Kataoka, M; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, A N; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Aushev, V; Son, D; De Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jiménez, M; Labarga, L; Del Peso, J; Ron, E; Soares, M; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, B A; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, R K; Ermolov, P F; Gladilin, L K; Khein, L A; Korzhavina, I A; Kuzmin, V A; Levchenko, B B; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Zotkin, D S; Zotkin, S A; Abt, I; Büttner, C; Caldwell, A; Kollar, D; Schmidke, W B; Sutiak, J; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H; Vázquez, M; Wiggers, L; Brümmer, N; Bylsma, B; Durkin, L S; Lee, A; Ling, T Y; Allfrey, P D; Bell, M A; Cooper-Sarkar, A M; Cottrell, A; Devenish, R C E; Foster, B; Korcsak-Gorzo, K; Patel, S; Roberfroid, V; Robertson, A; Straub, P B; Uribe-, C; Estrada; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Oh, B Y; Raval, A; Ukleja, J; Whitmore, J J; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, J E; Hart, J C; Abramowicz, H; Gabareen, A; Ingbir, R; Kananov, S; Levy, A; Kuze, M; Maeda, J; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, Y D; Ferrero, M I; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, J F; Boutle, S K; Butterworth, J M; Gwenlan, C; Jones, T W; Loizides, J H; Sutton, M R; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, R J; Pawlak, J M; Tymieniecka, T; Ukleja, A; Zarnecki, A F; Adamus, M; Plucinsky, P P; Eisenberg, Y; Giller, I; Hochman, D; Karshon, U; Rosin, M; Brownson, E; Danielson, T; Everett, A; Kcira, D; Reeder, D D; Ryan, P; Savin, A A; Smith, W H; Wolfe, H; Bhadra, S; Catterall, C D; Cui, Y; Hartner, G; Menary, S; Noor, U; Standage, J; Whyte, J

    2007-01-01

    The first observation of (anti)deuterons in deep inelastic scattering at HERA has been made with the ZEUS detector at a centre-of-mass energy of 300--318 GeV using an integrated luminosity of 120 pb-1. The measurement was performed in the central rapidity region for transverse momentum per unit of mass in the range 0.3anti)proton yield by approximately three orders of magnitude, consistent with the world measurements.

  20. Expected Enhancement of the Primary Antiproton Flux at the Solar Minimum

    OpenAIRE

    Mitsui, T.; Maki, K.; Orito, S.

    1996-01-01

    We calculate the solar-modulated energy spectra of cosmic-ray antiprotons ($\\bar{p}$'s) from two candidate primary sources, i.e., evaporating primordial black holes and the annihilation of neutralino dark matter, as well as for the secondary $\\bar{p}$'s produced by cosmic-ray interactions with interstellar gas. A large enhancement toward the solar minimum phase emerges in the low-energy flux of $\\bar{p}$'s from the primary sources, whereas the flux of the secondary $\\bar{p}$'s, falling steepl...