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Sample records for antiproton radiotherapy peripheral

  1. Antiproton radiotherapy: peripheral dose from secondary neutrons

    DEFF Research Database (Denmark)

    Fahimian, Benjamin P.; DeMarco, John J.; Keyes, Roy

    2009-01-01

    is the normal tissue dose resulting from secondary neutrons produced in the annihilation of antiprotons on the nucleons of the target atoms. Here we present the first organ specific Monte Carlo calculations of normal tissue equivalent neutron dose in antiproton therapy through the use of a segmented CT......-based human phantom. The MCNPX Monte Carlo code was employed to quantify the peripheral dose for a cylindrical spread out Bragg peak representing a treatment volume of 1 cm diameter and 1 cm length in the frontal lobe of a segmented whole-body phantom of a 38 year old male. The secondary neutron organ dose...

  2. Antiproton Radiotherapy Peripheral Dose from Secondary Neutrons produced in the Annihilation of Antiprotons in the Target

    CERN Document Server

    Fahimian, Benjamin P; Keyes, Roy; Bassler, Niels; Iwamoto, Keisuke S; Zankl, Maria; Holzscheiter, Michael H

    2009-01-01

    The AD-4/ACE collaboration studies the biological effects of antiprotons with respect to a possible use of antiprotons in cancer therapy. In vitro experiments performed by the collaboration have shown an enhanced biological effectiveness for antiprotons relative to protons. One concern is the normal tissue dose resulting from secondary neutrons produced in the annihilation of antiprotons on the nucleons of the target atoms. Here we present the first organ specific Monte Carlo calculations of normal tissue equivalent neutron dose in antiproton therapy through the use of a segmented CT-based human phantom. The MCNPX Monte Carlo code was employed to quantify the peripheral dose for a cylindrical spread out Bragg peak representing a treatment volume of 1 cm diameter and 1 cm length in the frontal lobe of a segmented whole-body phantom of a 38 year old male. The secondary neutron organ dose was tallied as a function of energy and organ.

  3. Antiproton radiotherapy

    CERN Document Server

    Bassler, Niels; Beyer, Gerd; DeMarco, John J.; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Iwamoto, Keisuke S.; Jakel, Oliver; Knudsen, Helge V.; Kovacevic, Sandra; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen B.à; Solberg, Timothy D.; Sørensen, Brita S.; Vranjes, Sanja; Wouters, Bradly G.; Holzscheiter, Michael H.

    2008-01-01

    Antiprotons are interesting as a possible future modality in radiation therapy for the following reasons: When fast antiprotons penetrate matter, protons and antiprotons have near identical stopping powers and exhibit equal radiobiology well before the Bragg-peak. But when the antiprotons come to rest at the Bragg-peak, they annihilate, releasing almost 2 GeV per antiproton–proton annihilation. Most of this energy is carried away by energetic pions, but the Bragg-peak of the antiprotons is still locally augmented with ∼20–30 MeV per antiproton. Apart from the gain in physical dose, an increased relative biological effect also has been observed, which can be explained by the fact that some of the secondary particles from the antiproton annihilation exhibit high-LET properties. Finally, the weakly interacting energetic pions, which are leaving the target volume, may provide a real time feedback on the exact location of the annihilation peak. We have performed dosimetry experiments and investigated the rad...

  4. A systematic review of antiproton radiotherapy

    Directory of Open Access Journals (Sweden)

    Martin-Immanuel eBittner

    2014-01-01

    Full Text Available Antiprotons have been proposed as possible particles for radiotherapy; over the past years, the renewed interest in the potential biomedical relevance led to an increased research activity. It is the aim of this review to deliver a comprehensive overview regarding the evidence accumulated so far, analysing the background and depicting the current status of antiprotons in radiotherapy. A literature search has been conducted, including major scientific and commercial databases. All articles and a number of relevant conference abstracts published in the respective field have been included in this systematic review. The physical basis of antiproton radiotherapy is complex; however, the characterisation of the energy deposition profile supports its potential use in radiotherapy. Also the dosimetry improved considerably over the past few years. Regarding the biological properties, data on the effects on cells are presented; however, definite conclusions regarding the relative biological effectiveness cannot be made at the moment and radiobiological evidence of enhanced effectiveness remains scarce. In addition, there is new evidence supporting the potential imaging properties, for example for online dose verification. Clinical settings which might profit from the use of antiprotons have been further tracked. Judging from the evidence available so far, clinical constellations requiring optimal sparing in the entrance region of the beam and re-irradiations might profit most from antiproton radiotherapy. While several open questions remain to be answered, first steps towards a thorough characterisation of this interesting modality have been made.

  5. Neutron fluence in antiproton radiotherapy, measurements and simulations

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael H.; Petersen, Jørgen B.B.

    2010-01-01

    A significant part of the secondary particle spectrum from antiproton annihilation consists of fast neutrons, which may contribute to a significant dose background found outside the primary beam. Using a polystyrene phantom as a moderator, we have performed absolute measurements of the thermalized...... part of the fast neutron spectrum using Lithium-6 and -7 Fluoride TLD pairs. The experimental results are found to be in good agreement with simulations using the Monte Carlo particle transport code FLUKA. The thermal neutron kerma resulting from the measured thermal neutron fluence is insignificant...

  6. Relative Biological Effectiveness and Peripheral Damage of Antiproton Annihilation

    CERN Multimedia

    Kavanagh, J N; Kaiser, F; Tegami, S; Schettino, G; Kovacevic, S; Hajdukovic, D; Welsch, C P; Currell, F J; Toelli, H T; Doser, M; Holzscheiter, M; Herrmann, R; Timson, D J; Alsner, J; Landua, R; Knudsen, H; Comor, J; Moller, S P; Beyer, G

    2002-01-01

    The use of ions to deliver radiation to a body for therapeutic purposes has the potential to be significant improvement over the use of low linear energy transfer (LET) radiation because of the improved energy deposition profile and the enhanced biological effects of ions relative to photons. Proton therapy centers exist and are being used to treat patients. In addition, the initial use of heavy ions such as carbon is promising to the point that new treatment facilities are planned. Just as with protons or heavy ions, antiprotons can be used to deliver radiation to the body in a controlled way; however antiprotons will exhibit additional energy deposition due to annihilation of the antiprotons within the body. The slowing down of antiprotons in matter is similar to that of protons except at the very end of the range beyond the Bragg peak. Gray and Kalogeropoulos estimated the additional energy deposited by heavy nuclear fragments within a few millimeters of the annihilation vertex to be approximately 30 MeV (...

  7. Simulation of an antiprotons beam applied to the radiotherapy; Simulacao de um feixe de antiprotons aplicado a radioterapia

    Energy Technology Data Exchange (ETDEWEB)

    Prata, Leonardo de Almeida

    2006-07-15

    Results for the interaction of a antiproton beam with constituent nuclei of the organic matter are presented. This method regards of the application of an computational algorithm to determine quantitatively the differential cross sections for the scattered particles, starting from the interaction of these antiprotons with the nuclei, what will allow in the future to draw the isodose curve for antiproton therapy, once these beams are expected to be used in cancer treatment soon. The calculation will be done through the application of the concepts of the method of intranuclear cascade, providing yield and differential cross sections of the scattered particles, present in the software MCMC. Th algorithm was developed based on Monte Carlo's method, already taking into account a validate code. The following physical quantities are presented: the yield of secondary particles, their spectral and angular distributions for these interactions. For the energy range taken into account the more important emitted particles are protons, neutrons and pions. Results shown that emitted secondary particles can modify the isodose curves, because they present high yield and energy for transverse directions. (author)

  8. Antiproton therapy

    CERN Document Server

    Knudsen, Helge V; Bassler, Niels; Alsner, Jan; Beyer, Gerd-Jürgen; DeMarco, John J; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Iwamoto, Keisuke S; Jäkel, Oliver; Kovacevic, Sandra; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen B; Ratib, Osman; Solberg, Timothy D; Vranjes, Sanja; Wouters, Bradly G

    2008-01-01

    Radiotherapy is one of the most important means we have for the treatment of localised tumours. It is therefore essential to optimize the technique, and a lot of effort goes into this endeavour. Since the proposal by Wilson in 1946 [R.R. Wilson, Radiology use of fast protons, Radiology 47 (1946) 487.] that proton beams might be better than photon beams at inactivating cancer cells, hadron therapy has been developed in parallel with photon therapy and a substantial knowledge has been gained on the effects of pions, protons and heavy ions (mostly carbon ions). Here we discuss the recent measurements by the CERN ACE collaboration of the biological effects of antiprotons, and argue that these particles very likely are the optimal agents for radiotherapy.

  9. V-79 Chinese Hamster Cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation

    DEFF Research Database (Denmark)

    Kovacevic, Sandra; Bassler, Niels; Hartley, Oliver

    2009-01-01

    Purpose: Radiotherapy of cancer carries a perceived risk of inducing secondary cancer and other damage due to dose delivered to normal tissue. While expectedly small, this risk must be carefully analysed for all modalities. Especially in the use of exotic particles like pions and antiprotons, which...... annihilate and produce a mixed radiation field when interacting with normal matter nuclei, the biological effective dose far out of field needs to be considered in evaluating this approach. We describe first biological measurements to address the concern that medium and long range annihilation products may...

  10. Neutrons from Antiproton Irradiation

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael; Petersen, Jørgen B.B.

    Background: Radiotherapy with Antiprotons is currently investigated by the AD-4/ACE collaboration. The hypothesis is that the additional energy released from the antiprotons annihilating at the target nuclei can enable a reduced dose in the entry channel of the primary beam. Furthermore an enhanced...... relative biological effect (RBE) has already been beam measured in spread out Bragg peaks of antiprotons, relative to that found in the plateau region. However, the antiproton annihilation process is associated with a substantial release of secondary particles which contribute to the dose outside...... the neutron spectrum. Additionally, we used a cylindrical polystyrene loaded with several pairs of thermoluminescent detectors containing Lithium-6 and Lithium-7, which effectively detects thermalized neutrons. The obtained results are compared with FLUKA imulations. Results: The results obtained...

  11. Calculated LET-Spectrum of Antiprotons

    DEFF Research Database (Denmark)

    Bassler, Niels

    Introduction Antiprotons as a new beam modality in radiotherapy are being investigated by the AD-4/ACE collaboration since 2002. A beam of antiprotons hitting a water phantom exhibit a similar depth-dose curve as that known from protons, except that the Bragg-peak is significantly pronounced due...

  12. Antiprotonic helium

    CERN Multimedia

    Eades, John

    2005-01-01

    An exotic atom in w hich an electron and an antiproton orbit a helium nucleus could reveal if there are any differences between matter and antimatter. The author describes this unusual mirror on the antiworld (5 pages)

  13. Antiproton Target

    CERN Multimedia

    1980-01-01

    Antiproton target used for the AA (antiproton accumulator). The first type of antiproton production target used from 1980 to 1982 comprised a rod of copper 3mm diameter and 120mm long embedded in a graphite cylinder that was itself pressed into a finned aluminium container. This assembly was air-cooled and it was used in conjunction with the Van der Meer magnetic horn. In 1983 Fermilab provided us with lithium lenses to replace the horn with a view to increasing the antiproton yield by about 30%. These lenses needed a much shorter target made of heavy metal - iridium was chosen for this purpose. The 50 mm iridium rod was housed in an extension to the original finned target container so that it could be brought very close to the entrance to the lithium lens. Picture 1 shows this target assembly and Picture 2 shows it mounted together with the lithium lens. These target containers had a short lifetime due to a combination of beam heating and radiation damage. This led to the design of the water-cooled target in...

  14. The Antiproton Accumulator becomes Antiproton Decelerator

    CERN Multimedia

    1980-01-01

    The photos show the Antiproton Accumulator (AA) transformed into Antiproton Decelerator. The AA was used at CERN between 1981 and 1999 before being replaced by the Antiproton Decelerator (AD). The AA was used to collect and stochastically cool antiprotons used in proton-antiproton collisions in the SPS collider. This lead to the discovery of the W and Z bosons in 1983 and the Nobel Prize for Carlo Rubbia and Simon van der Meer in 1984.

  15. Radiotherapy

    Directory of Open Access Journals (Sweden)

    Rema Jyothirmayi

    1999-01-01

    Full Text Available Purpose. Conservative treatment in the form of limited surgery and post-operative radiotherapy is controversial in hand and foot sarcomas, both due to poor radiation tolerance of the palm and sole, and due to technical difficulties in achieving adequate margins.This paper describes the local control and survival of 41 patients with soft tissue sarcoma of the hand or foot treated with conservative surgery and radiotherapy. The acute and late toxicity of megavoltage radiotherapy to the hand and foot are described. The technical issues and details of treatment delivery are discussed. The factors influencing local control after radiotherapy are analysed.

  16. The biological effectiveness of antiproton irradiation

    DEFF Research Database (Denmark)

    Holzscheiter, Michael H.; Bassler, Niels; Agazaryan, Nzhde;

    2006-01-01

    Background and purpose: Antiprotons travel through tissue in a manner similar to that for protons until they reach the end of their range where they annihilate and deposit additional energy. This makes them potentially interesting for radiotherapy. The aim of this study was to conduct the first e...

  17. Evaluation of the peripheral dose to uterus in breast carcinoma radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Martin-Rincon, C.; Jerez Sainz, I.; Modelell Farre, I.; Espana Lopez, M.L.; Lopez Franco, P.; Muniz, J.L.; Romero, A.M.; Rodriguez, R

    2002-07-01

    The absorbed dose outside of the direct fields of radiotherapy treatment (or peripheral dose, PD) is responsible for radiation exposure of the fetus in pregnant women. Because the radiological protection of the unborn child is of particular concern in the early period of the pregnancy, the aim of this study is to estimate the PD in order to assess the absorbed dose in the uterus in a pregnant patient irradiated for breast carcinoma therapy. The treatment was simulated on an Alderson-Rando anthropomorphic phantom, and the radiation dose to the fetus was measured using an ionisation chamber and thermoluminescence dosemeters. Two similar treatments plans with and without wedges were delivered, using a 6 MV photon beam with two isocentric opposite tangential fields with a total dose of 50 Gy, in accordance with common established procedures. Average field parameters for more than 300 patients were studied. Measurements showed the fetal dose to be slightly lower than 50 mGy, a level at which the risk to the fetus is uncertain, although several authors consider this value as the dose threshold for deterministic effects. The planning system underestimated PD values and no significant influence was found with the use of wedge filters. (author)

  18. Physics using cold antiprotons

    Science.gov (United States)

    Hayano, Ryugo S.

    2004-10-01

    Recent progress of low-energy antiproton physics by atomic spectroscopy and collisions using slow antiprotons collaboration at CERN AD is presented. High-precision spectroscopy of antiprotonic helium-a neutral three-body system overlinepe-He2+(=overlinepHe+) produced when antiprotons (overlinep) are stopped in various phases of helium-has tested 3-body QED theories as well as proton-vs-antiproton CPT to within ∼10-8. This was achieved by using a newly-developed radiofrequency quadrupole decelerator. Other ongoing and future experiments using low-energy antiprotons are discussed.

  19. Physics using cold antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Hayano, R.S. E-mail: hayano@phys.s.u-tokyo.ac.jp

    2004-10-11

    Recent progress of low-energy antiproton physics by atomic spectroscopy and collisions using slow antiprotons collaboration at CERN AD is presented. High-precision spectroscopy of antiprotonic helium--a neutral three-body system pbare{sup -}He{sup 2+}(=pbarHe{sup +}) produced when antiprotons (pbar) are stopped in various phases of helium--has tested 3-body QED theories as well as proton-vs-antiproton CPT to within {approx}10{sup -8}. This was achieved by using a newly-developed radiofrequency quadrupole decelerator. Other ongoing and future experiments using low-energy antiprotons are discussed.

  20. SU-E-T-43: Analytical Model for Photon Peripheral Dose in Radiotherapy Treatments

    Energy Technology Data Exchange (ETDEWEB)

    Nieto, B Sanchez; El far, R [Instituto de Fisica, Pontificia Universidad Catolica de Chile, Santiago, Santiago De Chile (Chile); Romero-Exposito, M [Universitat Autonoma de Barcelona, Barcelona (Spain); Lagares, J [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Madrid (Spain); Mateo, JC [Hospital Duques del Infantado, Sevilla (Spain); Terron, JA [Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla (Spain); Irazola, L; Sanchez-Doblado, F [Servicio de Radiofisica, Hospital Universitario Virgen Macarena, Sevilla (Spain); Departamento de Fisiologia Medica y Biofisica, Universidad de Sevilla, Sevilla (Spain)

    2014-06-01

    Purpose: The higher survival rate of radiotherapy patients entails a growing concern on second cancers associated to peripheral doses. Currently, dosimetry of out-of field doses is still under development. Our group has developed a methodology to estimate neutron equivalent dose in organs (1,2). We aimed to propose a model to estimate out-of-field photon doses in isocentric treatments from basic clinical data. Methods: The proposed function models the dose as the sum of leakage and scatter terms. The latter is modeled as a virtual source at the collimator, which suffers from attenuation in air and tissue, corrected by the inverse-square-law. The model was parameterized using experimental measurements with TLD700 chips placed inside an anthropomorphic phantom (6–18MV) irradiated with conformal and modulated techniques in Elekta, Siemens and Varian linacs. This model provides photon dose at a point as a function of clinical parameters as prescription dose/UM, PTV volume, distance to the field edge, height of the MLC leaves and distance from the the MLC to the isocenter. Model was tested against independent measurements (TLD100) for a VMAT treatment on a Elekta. Dose to organs is modeled from dose to points along the head-to-feet axis of the organ of a “standard man” escalated by patient height. Results: Our semi-empirical model depends on 3 given parameters (leakage parameter can be individualized). A novelty of our model, over other models (e.g., PERIDOSE), arises from its applicability to any technique (independently of the number of MU needed to deliver a dose). Differences between predictions and measurements were < 0.005mSv/UM. Conclusion: We have proposed a unique model which successfully account for photon peripheral organ dose. This model can be applied in the day-to-day clinic as it only needs a few basic parameters which are readily accessible.1. Radiother. Oncol. 107:234–243, 2013. 2. Phys. Med. Biol. 57:6167–6191, 2012.

  1. Antiproton-Decelerator (AD)

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    When the Low-Energy Antiproton Ring (LEAR) was stopped in 1996, because of its costly operation, a cheaper way of continuing low-energy antiproton physics was sought. The Antiproton-Collector (AC), added in 1987 to the Antiproton Accumulator (AA) to provide a tenfold intensity increase, was converted into the Antiproton-Decelerator (AD). Antiprotons from the target at 3.5 GeV/c are decelerated to 100 MeV/c, and fast-ejected to the experiments. Major changes were necessary. Above all, the conversion from a constant-field machine to one with a magnetic cycle, modulating the field by an impressive factor 35. New systems for stochastic and electron cooling had to be added. Beam diagnostics at an intensity of only 2E7 antiprotons was a challenge. In 2000, the AD began delivery of antiprotons to the experiments.

  2. Antiproton Accumulator (AA)

    CERN Multimedia

    Photographic Service

    1980-01-01

    The AA in its final stage of construction, before it disappeared from view under concrete shielding. Antiprotons were first injected, stochastically cooled and accumulated in July 1980. From 1981 on, the AA provided antiprotons for collisions with protons, first in the ISR, then in the SPS Collider. From 1983 on, it also sent antiprotons, via the PS, to the Low-Energy Antiproton Ring (LEAR). The AA was dismantled in 1997 and shipped to Japan.

  3. Antiprotons get biological

    CERN Multimedia

    2003-01-01

    After its final run in September, the first results of the Antiproton Cell Experiment (ACE) look very promising. It was the first experiment to take data on the biological effects of antiproton beams to evaluate the potential of antiprotons in radiation therapy.

  4. Nuclear Excitations by Antiprotons and Antiprotonic Atoms

    CERN Multimedia

    2002-01-01

    The proposal aims at the investigation of nuclear excitations following the absorption and annihilation of stopped antiprotons in heavier nuclei and at the same time at the study of the properties of antiprotonic atoms. The experimental arrangement will consist of a scintillation counter telescope for the low momentum antiproton beam from LEAR, a beam degrader, a pion multiplicity counter, a monoisotopic target and Ge detectors for radiation and charged particles. The data are stored by an on-line computer.\\\\ \\\\ The Ge detectors register antiprotonic x-rays and nuclear @g-rays which are used to identify the residual nucleus and its excitation and spin state. Coincidences between the two detectors will indicate from which quantum state the antiprotons are absorbed and to which nuclear states the various reactions are leading. The measured pion multiplicity characterizes the annihilation process. Ge&hyphn. and Si-telescopes identify charged particles and determine their energies.\\\\ \\\\ The experiment will gi...

  5. antiproton focusing horn

    CERN Multimedia

    1980-01-01

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet. For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 - three hundred thousand million - antiprotons.

  6. Antiproton Focus Horn

    CERN Multimedia

    1974-01-01

    Was used for the AA (antiproton accumulator). Making an antiproton beam took a lot of time and effort. Firstly, protons were accelerated to an energy of 26 GeV in the PS and ejected onto a metal target. From the spray of emerging particles, a magnetic horn picked out 3.6 GeV antiprotons for injection into the AA through a wide-aperture focusing quadrupole magnet.For a million protons hitting the target, just one antiproton was captured, 'cooled' and accumulated. It took 3 days to make a beam of 3 x 10^11 -, three hundred thousand million - antiprotons.

  7. Physics with thermal antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Hynes, M.V.; Campbell, L.J.

    1988-01-01

    The same beam cooling techniques that have allowed for high luminosity antiproton experiments at high energy also provide the opportunity for experiments at ultra-low energy. Through a series of deceleration stages, antiprotons collected and cooled at the peak momentum for production can by made available at thermal or sub-thermal energies. In particular, the CERN, PS-200 collaboration is developing an RFO-plused ion trap beam line for the antiproton gravitational mass experiment at LEAR that will provide beams of antiprotons in the energy range 0.001--1000.0 eV. Antiprotons at these energies make these fundamentals particles available for experiments in condensed matter and atomic physics. The recent speculation that antiprotons may form metastable states in some forms of normal matter could open many new avenues of basic and applied research. 7 refs., 3 figs.

  8. ASACUSA hits antiproton jackpot

    CERN Multimedia

    2001-01-01

    The Japanese-European ASACUSA collaboration, which takes its name from the oldest district of Tokyo, approaches the antimatter enigma in a different way from the other two AD experiments, by inserting antiprotons into ordinary atoms. Last month the collaboration succeeded in trapping about a million antiprotons. The ASACUSA antiproton trap (lower cylinder), surmounted by its liquid helium reservoir. Looking on are Ken Yoshiki-Franzen, Zhigang Wang, Takahito Tasaki, Suzanne Reed, John Eades, Masaki Hori, Yasunori Yamazaki, Naofumi Kuroda, Jun Sakaguchi, Berti Juhasz, Eberhard Widmann and Ryu Hayano. A key element of the ASACUSA apparatus is its decelerating Radiofrequency Quadrupole magnet, RFQD. After tests with protons in Aarhus, this was installed in ASACUSA's antiproton beam last October (Bulletin 41/2000, 9 October 2000). Constructed by Werner Pirkl's group in PS Division, the RFQD works by applying an electric field to the AD antiproton pulse the opposite direction to its motion. As the antiprotons slo...

  9. Comparison of Optimized Single and Multifield Irradiation Plans of Antiproton, Proton and Carbon Ion Beams

    DEFF Research Database (Denmark)

    Bassler, Niels; Kantemiris, Ioannis; Karaiskos, Pantelis;

    2010-01-01

    Antiprotons have been suggested as a possibly superior modality for radiotherapy, due to the energy released when antiprotons annihilate, which enhances the Bragg peak and introduces a high-LET component to the dose. However, concerns are expressed about the inferior lateral dose distribution...

  10. LEAR: antiproton extraction lines

    CERN Multimedia

    Photographic Service

    1992-01-01

    Antiprotons, decelerated in LEAR to a momentum of 100 MeV/c (kinetic energy of 5.3 MeV), were delivered to the experiments in an "Ultra-Slow Extraction", dispensing some 1E9 antiprotons over times counted in hours. Beam-splitters and a multitude of beam-lines allowed several users to be supplied simultaneously.

  11. The Antiproton Decelerator

    CERN Multimedia

    Laurent Guiraud

    1998-01-01

    A technician works on the Antiproton Decelerator (AD) ring. This machine slows down antiprotons so that they can combine with anti-electrons (positrons) and produce anti-hydrogen. Experiments are set up on the AD to attempt to store antihydrogen and investigate properties of anti-hydrogen, such as its mass.

  12. Antiproton charge radius

    Science.gov (United States)

    Crivelli, P.; Cooke, D.; Heiss, M. W.

    2016-09-01

    The upcoming operation of the extra low energy antiprotons ring at CERN, the upgrade of the antiproton decelerator (AD), and the installation in the AD hall of an intense slow positron beam with an expected flux of 1 08 e+ /s will open the possibility for new experiments with antihydrogen (H ¯). Here we propose a scheme to measure the Lamb shift of H ¯. For four months of data taking, we anticipate an uncertainty of 100 ppm. This will provide a test of C P T and the first determination of the antiproton charge radius at the level of 10%.

  13. Evaluation of the peripheral dose in stereotactic radiotherapy and radiosurgery treatments

    Energy Technology Data Exchange (ETDEWEB)

    Di Betta, Erika; Fariselli, Laura; Bergantin, Achille; Locatelli, Federica; Del Vecchio, Antonella; Broggi, Sara; Fumagalli, Maria Luisa [Department of Neurosurgery, Division of Medical Physics, Fondazione IRCCS, Istituto Neurologico C. Besta, 20133 Milano (Italy); Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS, Istituto Neurologico C. Besta, 20133 Milano (Italy); CyberKnife Centre, Centro Diagnostico Italiano, 20147 Milano (Italy); Division of Medical Physics, Fondazione IRCCS, Istituto S. Raffaele, 20132 Milano (Italy); Department of Neurosurgery, Division of Medical Physics, Fondazione IRCCS, Istituto Neurologico C. Besta, 20133 Milano (Italy)

    2010-07-15

    Purpose: The main purpose of this work was to compare peripheral doses absorbed during stereotactic treatment of a brain lesion delivered using different devices. These data were used to estimate the risk of stochastic effects. Methods: Treatment plans were created for an anthropomorphic phantom and delivered using a LINAC with stereotactic cones and a multileaf collimator, a CyberKnife system (before and after a supplemental shielding was applied), a TomoTherapy system, and a Gamma Knife unit. For each treatment, 5 Gy were prescribed to the target. Measurements were performed with thermoluminescent dosimeters inserted roughly in the position of the thyroid, sternum, upper lung, lower lung, and gonads. Results: Mean doses ranged from of 4.1 (Gamma Knife) to 62.8 mGy (LINAC with cones) in the thyroid, from 2.3 (TomoTherapy) to 30 mGy (preshielding CyberKnife) in the sternum, from 1.7 (TomoTherapy) to 20 mGy (preshielding CyberKnife) in the upper part of the lungs, from 0.98 (Gamma Knife) to 15 mGy (preshielding CyberKnife) in the lower part of the lungs, and between 0.3 (Gamma Knife) and 10 mGy (preshielding CyberKnife) in the gonads. Conclusions: The peripheral dose absorbed in the sites of interest with a 5 Gy fraction is low. Although the risk of adverse side effects calculated for 20 Gy delivered in 5 Gy fractions is negligible, in the interest of optimum patient radioprotection, further studies are needed to determine the weight of each contributor to the peripheral dose.

  14. Radiobiological modeling analysis of the optimal fraction scheme in patients with peripheral non-small cell lung cancer undergoing stereotactic body radiotherapy

    OpenAIRE

    Bao-Tian Huang; Jia-Yang Lu; Pei-Xian Lin; Jian-Zhou Chen; De-Rui Li; Chuang-Zhen Chen

    2015-01-01

    This study aimed to determine the optimal fraction scheme (FS) in patients with small peripheral non-small cell lung cancer (NSCLC) undergoing stereotactic body radiotherapy (SBRT) with the 4 × 12 Gy scheme as the reference. CT simulation data for sixteen patients diagnosed with primary NSCLC or metastatic tumor with a single peripheral lesion ≤3 cm were used in this study. Volumetric modulated arc therapy (VMAT) plans were designed based on ten different FS of 1 × 25 Gy, 1 × 30 Gy, 1 × 34 Gy...

  15. Biological Effectiveness of Antiproton Annihilation

    DEFF Research Database (Denmark)

    Maggiore, C.; Agazaryan, N.; Bassler, N.;

    2004-01-01

    from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The background, description, and status...

  16. Biological effectiveness of antiproton annihilation

    CERN Document Server

    Holzscheiter, Michael H.; Bassler, Niels; Beyer, Gerd; De Marco, John J.; Doser, Michael; Ichioka, Toshiyasu; Iwamoto, Keisuke S.; Knudsen, Helge V.; Landua, Rolf; Maggiore, Carl; McBride, William H.; Møller, Søren Pape; Petersen, Jorgen; Smathers, James B.; Skarsgard, Lloyd D.; Solberg, Timothy D.; Uggerhøj, Ulrik I.; Withers, H.Rodney; Vranjes, Sanja; Wong, Michelle; Wouters, Bradly G.

    2004-01-01

    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in “biological dose” in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

  17. Biological effectiveness of antiproton annihilation

    DEFF Research Database (Denmark)

    Holzscheiter, M.H.; Agazaryan, N.; Bassler, Niels;

    2004-01-01

    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct...... measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current...

  18. Antiproton Annihilation Propulsion

    Science.gov (United States)

    1985-09-01

    propulsion system, a nuclear thermal hydrogen propulsion system, and an antiproton annihilation propulsion system. Since hauling chemical fuel into low...greater. Section 8.4 and Appendix B contain a comparative cost study of a storable chemical fuel propulsion system, a liquid oxygen/liquid hydrogen

  19. Antiproton Cancer Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels

    of the secondary particles from the antiproton annihilation exihibt high-LET properties. Additionally, the high energy pions are leaving the target with minimal interactions and can be detected external to the body providing a real time feedback on the exact location of the energy deposition. In recent years, we...

  20. Coincidence studies with antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    McGovern, M; Walters, H R J [Department of Applied Mathematics and Theoretical Physics, Queen' s University, Belfast BT7 1NN (United Kingdom); Assafrao, D; Mohallem, J R [Laboratorio de Atomos e Moleculas Especiais, Departamento de Fisica, ICEx, Universidade Federal de Minas Gerais, P.O Box 702, 30123-970 Belo Horizonte, MG (Brazil); Whelan, Colm T, E-mail: mmcgovern06@qub.ac.u [Department of Physics, Old Dominion University, Norfolk, VA 23529-0116 (United States)

    2010-02-01

    We present a short overview of a new method for calculating fully differential cross sections that is able to describe any aspect of coincidence measurements involving heavy projectiles. The method is based upon impact parameter close coupling with pseudostates. Examples from antiproton impact ionization are shown.

  1. Calculated LET spectrum from antiproton beams stopping in water

    CERN Document Server

    Bassler, Niels

    2009-01-01

    Antiprotons have been proposed as a potential modality for radiotherapy because the annihilation at the end of range leads to roughly a doubling of physical dose in the Bragg peak region. So far it has been anticipated that the radiobiology of antiproton beams is similar to that of protons in the entry region of the beam, but very different in the annihilation region, due to the expected high-LET components resulting from the annihilation. On closer inspection we find that calculations of dose averaged LET in the entry region may suggest that the RBE of antiprotons in the plateau region could significantly differ from unity, which seems to warrant closer inspection of the radiobiology in this region. Materials and Methods. Monte Carlo simulations using FLUKA were performed for calculating the entire particle spectrum of a beam of 126 MeV antiprotons hitting a water phantom. Results and Discussion. In the plateau region of the simulated antiproton beam we observe a dose-averaged unrestrict...

  2. Evaluation of the in vivo genotoxic effects of gamma radiation on the peripheral blood leukocytes of head and neck cancer patients undergoing radiotherapy.

    Science.gov (United States)

    Kadam, Samit B; Shyama, Soorambail K; Almeida, Valentine G

    2013-04-15

    The present study aimed to evaluate the genotoxic effects of ionizing radiation on non-target cells of Head and Neck Squamous Cell Carcinoma (HNSCC) patients exposed to various cumulative doses of gamma rays during radiotherapy. The ten patients (P1-P10) were treated with cobalt 60 gamma radiation (External Beam Radiotherapy) for a period of five to six weeks with a daily fraction of 2Gy for 5 days each week. The genotoxic effects of radiation (single strand breaks - SSBs) in these patients were analyzed using the alkaline single cell gel electrophoresis (SCGE) technique, with the Olive Tail Moment (OTM) as the critical parameter. A sample of each patient's peripheral blood before starting with radiotherapy (pre-therapy) served as the control, and blood collected at weekly time intervals during the course of the radiotherapy served as treated (10, 20, 30, 40, 50 and 60Gy) samples. In vivo radiosensitivity of these patients, as indicated by SSB's after the cumulative radiation doses at the various times, was assessed using Student's t-test. Significant DNA damage relative to the individual patient's pre-therapy baseline data was observed in all patients. Inter-individual variation of the genotoxic effects was analyzed using two-way ANOVA. The correlation between doses for the means of smoker and non-smoker patients was calculated using the Pearson test. The results of this study may indicate the need to reduce the daily radiotherapy dose further to prevent genotoxic effects on non-target cells, thus improving safety. Furthermore, these results may indicate that the estimation of DNA damage following exposure to a gamma radiation, as measured by the comet assay in whole blood leukocytes, can be used to screen human populations for radiation-induced genetic damage at the molecular level.

  3. The toxicity of radiotherapy following high-dose chemotherapy with peripheral blood serum cell support in high-risk breast cancer: a preliminary analysis

    Energy Technology Data Exchange (ETDEWEB)

    Wall, E. van der; Schaake-Koning, C.C.E.; Zandwijk, N. van [Nederlands Kanker Inst. `Antoni van Leeuwenhoekhuis`, Amsterdam (Netherlands)] [and others

    1996-08-01

    High-dose chemotherapy with autologous bone marrow and/or peripheral blood stem cell (PBSC) support is increasingly employed in the adjuvant treatment of high-risk breast cancer. Subsequent radiotherapy has been reported to be associated with morbidity and mortality resulting from pulmonary toxicity. In addition, the course of radiation therapy may be hampered by excess myelosuppression. The aim of this study was to investigate the contribution to radiation-induced toxicity of a high-dose chemotherapy regimen (CTC) that incorporates cyclophosphamide, thiotepa and carboplatin, in patients with high-risk breast cancer. (author).

  4. Antiproton Radiation Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael H.; Petersen, Jørgen B.B.

    2007-01-01

    the radiobiological properties using antiprotons at 50 and 125 MeV from the Antiproton Decelerator (AD) at CERN. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film. Radiobiological experiments were done with Chinese V79 WNRE hamster cells. Monte Carlo particle...... transport codes were investigated and compared with results obtained from the ionization chambers and alanine pellets. A track structure model have been applied on the calculated particle spectrum, and been used to predict the LET-dependent response of the alanine pellets. The particle transport program...... FLUKA produced data which were in excellent agreement with our ionization chamber measurements, and in good agreement with our alanine measurements. FLUKA is now being used to generate a wide range of depth dose data at several energies, including secondary particle–energy spectra, which will be used...

  5. Bubble chamber: antiproton annihilation

    CERN Multimedia

    1971-01-01

    These images show real particle tracks from the annihilation of an antiproton in the 80 cm Saclay liquid hydrogen bubble chamber. A negative kaon and a neutral kaon are produced in this process, as well as a positive pion. The invention of bubble chambers in 1952 revolutionized the field of particle physics, allowing real tracks left by particles to be seen and photographed by expanding liquid that had been heated to boiling point.

  6. Antiproton compression and radial measurements

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Funakoshi, R; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jenkins, M J; Jorgensen, L V; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Page R D; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; Van der Werf, D P; Wurtele, J S; Yamazaki, Y

    2008-01-01

    Control of the radial profile of trapped antiproton clouds is critical to trapping antihydrogen. We report detailed measurements of the radial manipulation of antiproton clouds, including areal density compressions by factors as large as ten, achieved by manipulating spatially overlapped electron plasmas. We show detailed measurements of the near-axis antiproton radial profile, and its relation to that of the electron plasma. We also measure the outer radial profile by ejecting antiprotons to the trap wall using an octupole magnet.

  7. ALPHA freezes antiprotons

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Laboratories like CERN can routinely produce many different types of antiparticles. In 1995, the PS210 experiment formed the first antihydrogen atoms and a few years later, in 2002, ATRAP and ATHENA were already able to produce several thousand of them. However, no experiment in the world has succeeded in ‘trapping’ these anti-atoms in order to study them. This is the goal of the ALPHA experiment, which has recently managed to cool down the antiprotons to just a few Kelvin. This represents a major step towards trapping the anti-atom, thus opening a new avenue into the investigation of antimatter properties.   Members of the ALPHA collaboration working on the apparatus in the Antiproton Decelerator experimental hall at CERN. Just like the atom, the anti-atom is neutral. Unlike the atom, the anti-atom is made up of antiprotons (as opposed to protons in the atom) and positrons (as opposed to electrons). In order to thoroughly study the properties of the anti-atoms, scien...

  8. Extra Low ENergy Antiproton

    CERN Multimedia

    To produce dense antiproton beams at very low energies (110 keV), it has been proposed to install a small decelerator ring between the existing AD ring and the experimental area. Phase-space blowup during deceleration is compensated by electron cooling such that the final emittances are comparable to the 5MeV beam presently delivered by the AD. An immediate consequence is a significant increase in the number of trapped antiprotons at the experiments as outlined in the proposal CERN/SPSC-2009-026; SPCS-P-338. This report describes the machine parameters and layout of the proposal ELENA (Extra Low ENergy Antiproton)ring also gives an approximate estimate of cost and manpower needs. Since the initial estimate, published in 2007 (CERN-AB-2007-079), the ELENA design has evolved considerably. This is due to a new location in the AD hall to acommodate for the possibility of another experimental zone, as suggested by the SPCS, and also due to improvements in the ring optics and layout. The cost estimate that is prese...

  9. Unstable chromosome aberrations on peripheral blood lymphocytes from patients with cervical uterine cancer following radiotherapy; Aberracoes cromossomicas instaveis em linfocitos de pacientes com cancer de colo de utero

    Energy Technology Data Exchange (ETDEWEB)

    Magnata, Simey de Souza Leao Pereira

    2002-09-01

    Absorbed dose determination is an important step for risk assessment related to an exposure to ionizing radiation. However, physical dosimetry cannot be always performed, principally in the case of retrospective estimates. In this context, the use of bioindicators (biological effects) has been proposed, which defines the so-called biological dosimetry. In particular, scoring of unstable chromosomes aberrations (dicentrics, centric rings and fragments) of peripheral blood lymphocytes, while is the most reliable biological method for estimating individual exposure to ionizing radiation. In this work, blood samples from 5 patients, with cervical uterine cancer, were evaluated after partial-body radiotherapy with a source of {sup 69} Co. For this, conventional cytogenetic method was employed, based on Giemsa coloration and fluorescence in situ hybridization, in order to correlate the frequency of unstable chromosome aberrations of blood lymphocytes with absorbed dose, as a result of the radiotherapy. A good agreement was observed between the frequency of chromosome aberrations scored and the values of dose previously calculated by physical dosimetry during patient's radiotherapy. The results presented in this work point out the importance of concerning analyses of unstable chromosome aberrations as biological dosimeter in the investigation of partial-body exposure to ionizing radiation. (author)

  10. Peripheral dose from neutrons and photons in the radiation treatment of pelvic tumors with conventional technique or VMAT. A review; Periphere Neutronen- und Photonendosis bei der Radiotherapie von Tumoren des Beckens mit konventioneller Technik oder VMAT. Eine Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, P. [Medizinische Univ. Graz (Austria). Comprehensive Cancer Center

    2015-07-01

    Peripheral neutron and photon doses from external beam radiation therapy are associated with the risk of carcinogenesis in organs distant to the treated volume. In the irradiation of tumors and target volumes in the pelvis with convention photon-radiotherapy beams with high nominal energies (above 15 MeV) are typically used. During the last years volumetric modulated arc therapy (VMAT) techniques have gained a wide-spread use for pelvic treatments. The beam-energies that are primarily used in VMAT are below 10 MeV. Therefore, a reduction in peripheral dose due to the absence of neutrons can be expected when VMAT is utilized. On the other hand the number of monitor units is increased in increased in VMAT, as compared to conventional unmodulated fields, by a factor of two to three. This leads to an increase in transmission dose from the machine's treatment head, such that the potential benefit might be outbalanced. The question, whether the increasing use of VMAT might lead to a reduction of peripheral dose, is the subject of several studies. Those studies use either measurements in phantom settings or Monte-Carlo simulations. A systematic review of the literature shows diverging, and sometimes even contradictory, findings. Therefore, the issue of peripheral dose and the risk for secondary malignancies requires further investigation. In our opinion, the focus should be put on measurements and simulations, but also on modelling of dose-response correlations.

  11. ANTIPROTONS PRODUCED IN SUPERNOVA REMNANTS

    Energy Technology Data Exchange (ETDEWEB)

    Berezhko, E. G.; Ksenofontov, L. T., E-mail: ksenofon@ikfia.sbras.ru [Yu. G. Shafer Institute of Cosmophysical Research and Aeronomy, 31 Lenin Avenue, 677891 Yakutsk (Russian Federation)

    2014-08-20

    We present the energy spectrum of an antiproton cosmic ray (CR) component calculated on the basis of the nonlinear kinetic model of CR production in supernova remnants (SNRs). The model includes the reacceleration of antiprotons already existing in the interstellar medium as well as the creation of antiprotons in nuclear collisions of accelerated protons with gas nuclei and their subsequent acceleration by SNR shocks. It is shown that the production of antiprotons in SNRs produces a considerable effect in their resultant energy spectrum, making it essentially flatter above 10 GeV so that the spectrum at TeV energies increases by a factor of 5. The calculated antiproton spectrum is consistent with the PAMELA data, which correspond to energies below 100 GeV. As a consistency check, we have also calculated within the same model the energy spectra of secondary nuclei and show that the measured boron-to-carbon ratio is consistent with the significant SNR contribution.

  12. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling. In this picture, the 26 GeV high-intensity beam from the PS enters from the right, where a scintillator screen, with circles every 5 mm in radius, permits precise aim at the target centre. See also 7903034 and 7905094.

  13. AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing of stainless steel. At the entrance to the target assembly was a scintillator screen, imprinted with circles every 5 mm in radius, which allowed to precisely aim the 26 GeV high-intensity proton beam from the PS onto the centre of the target rod. The scintillator screen was a 1 mm thick plate of Cr-doped alumina. See also 7903034 and 7905091.

  14. Autoresonant Excitation of Antiproton Plasmas

    CERN Document Server

    Andresen, Gorm B; Baquero-Ruiz, Marcelo; Bertsche, William; Bowe, Paul D; Butler, Eoin; Carpenter, P T; Cesar, Claudio L; Chapman, Steven; Charlton, Michael; Fajans, Joel; Friesen, Tim; Fujiwara, Makoto C; Gill, David R; Hangst, Jeffrey S; Hardy, Walter N; Hayden, Michael E; Humphries, Andrew J; Hurt, J L; Hydomako, Richard; Jonsell, Svante; Madsen, Niels; Menary, Scott; Nolan, Paul; Olchanski, Konstantin; Olin, Art; Povilus, Alexander; Pusa, Petteri; Robicheaux, Francis; Sarid, Eli; Silveira, Daniel M; So, Chukman; Storey, James W; Thompson, Robert I; van der Werf, Dirk P; Wurtele, Jonathan S; Yamazaki, Yasunori

    2011-01-01

    We demonstrate controllable excitation of the center-of-mass longitudinal motion of a thermal antiproton plasma using a swept-frequency autoresonant drive. When the plasma is cold, dense, and highly collective in nature, we observe that the entire system behaves as a single-particle nonlinear oscillator, as predicted by a recent theory. In contrast, only a fraction of the antiprotons in a warm plasma can be similarly excited. Antihydrogen was produced and trapped by using this technique to drive antiprotons into a positron plasma, thereby initiating atomic recombination.

  15. A reservoir trap for antiprotons

    CERN Document Server

    Smorra, Christian; Franke, Kurt; Nagahama, Hiroki; Schneider, Georg; Higuchi, Takashi; Van Gorp, Simon; Blaum, Klaus; Matsuda, Yasuyuki; Quint, Wolfgang; Walz, Jochen; Yamazaki, Yasunori; Ulmer, Stefan

    2015-01-01

    We have developed techniques to extract arbitrary fractions of antiprotons from an accumulated reservoir, and to inject them into a Penning-trap system for high-precision measurements. In our trap-system antiproton storage times > 1.08 years are estimated. The device is fail-safe against power-cuts of up to 10 hours. This makes our planned comparisons of the fundamental properties of protons and antiprotons independent from accelerator cycles, and will enable us to perform experiments during long accelerator shutdown periods when background magnetic noise is low. The demonstrated scheme has the potential to be applied in many other precision Penning trap experiments dealing with exotic particles.

  16. Experimental setup and first measurement of DNA damage induced along and around an antiproton beam

    DEFF Research Database (Denmark)

    Kavanagh, J. N.; Currell, F. J.; Timson, D. J.;

    2010-01-01

    Radiotherapy employs ionizing radiation to induce lethal DNA lesions in cancer cells while minimizing damage to healthy tissues. Due to their pattern of energy deposition, better therapeutic outcomes can, in theory, be achieved with ions compared to photons. Antiprotons have been proposed to offe...

  17. Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients.

    Science.gov (United States)

    Napolitano, Maria; D'Alterio, Crescenzo; Cardone, Eleonora; Trotta, Anna Maria; Pecori, Biagio; Rega, Daniela; Pace, Ugo; Scala, Dario; Scognamiglio, Giosuè; Tatangelo, Fabiana; Cacciapuoti, Carmela; Pacelli, Roberto; Delrio, Paolo; Scala, Stefania

    2015-04-10

    Short-course preoperative radiotherapy (SC-RT) followed by total mesorectal excision (TME) is one therapeutic option for locally advanced rectal cancer (LARC) patients. Since radio-induced DNA damage may affect tumor immunogenicity, Myeloid-derived suppressor cells (MDSCs) and T regulatory cells (Tregs) were evaluated in 13 patients undergoing SC-RT and TME for LARC. Peripheral Granulocytic-MDSCs (G-MDSC) [LIN-/HLA-DR-/CD11b+/CD14-/CD15+/CD33+], Monocytic (M-MDSC) [CD14+/HLA-DR-/lowCD11b+/CD33+] and Tregs [CD4+/CD25hi+/FOXP3+- CTLA-4/PD1] basal value was significantly higher in LARC patients compared to healthy donors (HD). Peripheral MDSC and Tregs were evaluated at time 0 (T0), after 2 and 5 weeks (T2-T5) from radiotherapy; before surgery (T8) and 6-12 months after surgery (T9, T10). G-MDSC decreased at T5 and further at T8 while M-MDSC cells decreased at T5; Tregs reached the lowest value at T5. LARC poor responder patients displayed a major decrease in M-MDSC after SC-RT and an increase of Treg-PD-1. In this pilot study MDSCs and Tregs decrease during the SC-RT treatment could represent a biomarker of response in LARC patients. Further studies are needed to confirm that the deepest M-MDSC reduction and increase in Treg-PD1 cells within 5-8 weeks from the beginning of treatment could discriminate LARC patients poor responding to SC-RT.

  18. The Antiproton Accumulator (AA)

    CERN Multimedia

    1980-01-01

    Section 06 - 08*) of the AA where the dispersion (and hence the horizontal beam size) is large. One can distinguish (left to right): A vacuum-tank, two bending magnets (BST06 and BST07 in blue) with a quadrupole (QDN07, in red) in between, another vacuum-tank, a wide quadrupole (QFW08) and a further tank . The tanks are covered with heating tape for bake-out. The tank left of BST06 contained the stack core pickup for stochastic cooling (see 7906193, 7906190, 8005051), the two other tanks served mainly as vacuum chambers in the region where the beam was large. Peter Zettwoch works on BST06. *) see: H. Koziol, Antiproton Accumulator Parameter List, PS/AA/Note 84-2 (1984)

  19. Comparison of electromagnetic and hadronic models generated using Geant 4 with antiproton dose measured in CERN.

    Science.gov (United States)

    Tavakoli, Mohammad Bagher; Reiazi, Reza; Mohammadi, Mohammad Mehdi; Jabbari, Keyvan

    2015-01-01

    After proposing the idea of antiproton cancer treatment in 1984 many experiments were launched to investigate different aspects of physical and radiobiological properties of antiproton, which came from its annihilation reactions. One of these experiments has been done at the European Organization for Nuclear Research known as CERN using the antiproton decelerator. The ultimate goal of this experiment was to assess the dosimetric and radiobiological properties of beams of antiprotons in order to estimate the suitability of antiprotons for radiotherapy. One difficulty on this way was the unavailability of antiproton beam in CERN for a long time, so the verification of Monte Carlo codes to simulate antiproton depth dose could be useful. Among available simulation codes, Geant4 provides acceptable flexibility and extensibility, which progressively lead to the development of novel Geant4 applications in research domains, especially modeling the biological effects of ionizing radiation at the sub-cellular scale. In this study, the depth dose corresponding to CERN antiproton beam energy by Geant4 recruiting all the standard physics lists currently available and benchmarked for other use cases were calculated. Overall, none of the standard physics lists was able to draw the antiproton percentage depth dose. Although, with some models our results were promising, the Bragg peak level remained as the point of concern for our study. It is concluded that the Bertini model with high precision neutron tracking (QGSP_BERT_HP) is the best to match the experimental data though it is also the slowest model to simulate events among the physics lists.

  20. Comparison of electromagnetic and hadronic models generated using Geant 4 with antiproton dose measured in CERN

    Directory of Open Access Journals (Sweden)

    Mohammad Bagher Tavakoli

    2015-01-01

    Full Text Available After proposing the idea of antiproton cancer treatment in 1984 many experiments were launched to investigate different aspects of physical and radiobiological properties of antiproton, which came from its annihilation reactions. One of these experiments has been done at the European Organization for Nuclear Research known as CERN using the antiproton decelerator. The ultimate goal of this experiment was to assess the dosimetric and radiobiological properties of beams of antiprotons in order to estimate the suitability of antiprotons for radiotherapy. One difficulty on this way was the unavailability of antiproton beam in CERN for a long time, so the verification of Monte Carlo codes to simulate antiproton depth dose could be useful. Among available simulation codes, Geant4 provides acceptable flexibility and extensibility, which progressively lead to the development of novel Geant4 applications in research domains, especially modeling the biological effects of ionizing radiation at the sub-cellular scale. In this study, the depth dose corresponding to CERN antiproton beam energy by Geant4 recruiting all the standard physics lists currently available and benchmarked for other use cases were calculated. Overall, none of the standard physics lists was able to draw the antiproton percentage depth dose. Although, with some models our results were promising, the Bragg peak level remained as the point of concern for our study. It is concluded that the Bertini model with high precision neutron tracking (QGSP_BERT_HP is the best to match the experimental data though it is also the slowest model to simulate events among the physics lists.

  1. Antiproton Cancer Therapy

    DEFF Research Database (Denmark)

    Bassler, Niels

    An essential part in cancer radiotherapy, is to direct a sufficiently high dose towards the tumour, without damaging the surrounding tissue. Different techniques such as intensity modulated radiation therapy and proton therapy have been developed, in order to reduce the dose to the normal tissue...

  2. Measurement of interaction between antiprotons

    Science.gov (United States)

    The Star Collaboration; Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Alford, J.; Aparin, A.; Arkhipkin, D.; Aschenauer, E. C.; Averichev, G. S.; Bairathi, V.; Banerjee, A.; Bellwied, R.; Bhasin, A.; Bhati, A. K.; Bhattarai, P.; Bielcik, J.; Bielcikova, J.; Bland, L. C.; Bordyuzhin, I. G.; Bouchet, J.; Brandenburg, J. D.; Brandin, A. V.; Bunzarov, I.; Butterworth, J.; Caines, H.; Calderón de La Barca Sánchez, M.; Campbell, J. M.; Cebra, D.; Cervantes, M. C.; Chakaberia, I.; Chaloupka, P.; Chang, Z.; Chattopadhyay, S.; Chen, J. H.; Chen, X.; Cheng, J.; Cherney, M.; Christie, W.; Contin, G.; Crawford, H. J.; Das, S.; de Silva, L. C.; Debbe, R. R.; Dedovich, T. G.; Deng, J.; Derevschikov, A. A.; di Ruzza, B.; Didenko, L.; Dilks, C.; Dong, X.; Drachenberg, J. L.; Draper, J. E.; Du, C. M.; Dunkelberger, L. E.; Dunlop, J. C.; Efimov, L. G.; Engelage, J.; Eppley, G.; Esha, R.; Evdokimov, O.; Eyser, O.; Fatemi, R.; Fazio, S.; Federic, P.; Fedorisin, J.; Feng, Z.; Filip, P.; Fisyak, Y.; Flores, C. E.; Fulek, L.; Gagliardi, C. A.; Garand, D.; Geurts, F.; Gibson, A.; Girard, M.; Greiner, L.; Grosnick, D.; Gunarathne, D. S.; Guo, Y.; Gupta, A.; Gupta, S.; Guryn, W.; Hamad, A.; Hamed, A.; Haque, R.; Harris, J. W.; He, L.; Heppelmann, S.; Heppelmann, S.; Hirsch, A.; Hoffmann, G. W.; Hofman, D. J.; Horvat, S.; Huang, B.; Huang, H. Z.; Huang, X.; Huck, P.; Humanic, T. J.; Igo, G.; Jacobs, W. W.; Jang, H.; Jiang, K.; Judd, E. G.; Kabana, S.; Kalinkin, D.; Kang, K.; Kauder, K.; Ke, H. W.; Keane, D.; Kechechyan, A.; Khan, Z. H.; Kikoła, D. P.; Kisel, I.; Kisiel, A.; Klein, S.; Kochenda, L.; Koetke, D. D.; Kollegger, T.; Kosarzewski, L. K.; Kraishan, A. F.; Kravtsov, P.; Krueger, K.; Kulakov, I.; Kumar, L.; Kycia, R. A.; Lamont, M. A. C.; Landgraf, J. M.; Landry, K. D.; Lauret, J.; Lebedev, A.; Lednicky, R.; Lee, J. H.; Li, X.; Li, Z. M.; Li, Y.; Li, W.; Li, X.; Li, C.; Lisa, M. A.; Liu, F.; Ljubicic, T.; Llope, W. J.; Lomnitz, M.; Longacre, R. S.; Luo, X.; Ma, G. L.; Ma, R.; Ma, Y. G.; Ma, L.; Magdy, N.; Majka, R.; Manion, A.; Margetis, S.; Markert, C.; Masui, H.; Matis, H. S.; McDonald, D.; Meehan, K.; Minaev, N. G.; Mioduszewski, S.; Mishra, D.; Mohanty, B.; Mondal, M. M.; Morozov, D. A.; Mustafa, M. K.; Nandi, B. K.; Nasim, Md.; Nayak, T. K.; Nigmatkulov, G.; Nogach, L. V.; Noh, S. Y.; Novak, J.; Nurushev, S. B.; Odyniec, G.; Ogawa, A.; Oh, K.; Okorokov, V.; Olvitt, D.; Page, B. S.; Pak, R.; Pan, Y. X.; Pandit, Y.; Panebratsev, Y.; Pawlik, B.; Pei, H.; Perkins, C.; Peterson, A.; Pile, P.; Planinic, M.; Pluta, J.; Poljak, N.; Poniatowska, K.; Porter, J.; Posik, M.; Poskanzer, A. M.; Putschke, J.; Qiu, H.; Quintero, A.; Ramachandran, S.; Raniwala, R.; Raniwala, S.; Ray, R. L.; Ritter, H. G.; Roberts, J. B.; Rogachevskiy, O. V.; Romero, J. L.; Roy, A.; Ruan, L.; Rusnak, J.; Rusnakova, O.; Sahoo, N. R.; Sahu, P. K.; Sakrejda, I.; Salur, S.; Sandweiss, J.; Sarkar, A.; Schambach, J.; Scharenberg, R. P.; Schmah, A. M.; Schmidke, W. B.; Schmitz, N.; Seger, J.; Seyboth, P.; Shah, N.; Shahaliev, E.; Shanmuganathan, P. V.; Shao, M.; Sharma, M. K.; Sharma, B.; Shen, W. Q.; Shi, S. S.; Shou, Q. Y.; Sichtermann, E. P.; Sikora, R.; Simko, M.; Skoby, M. J.; Smirnov, N.; Smirnov, D.; Song, L.; Sorensen, P.; Spinka, H. M.; Srivastava, B.; Stanislaus, T. D. S.; Stepanov, M.; Stock, R.; Strikhanov, M.; Stringfellow, B.; Sumbera, M.; Summa, B.; Sun, Z.; Sun, X. M.; Sun, Y.; Sun, X.; Surrow, B.; Svirida, N.; Szelezniak, M. A.; Tang, Z.; Tang, A. H.; Tarnowsky, T.; Tawfik, A.; Thomas, J. H.; Timmins, A. R.; Tlusty, D.; Tokarev, M.; Trentalange, S.; Tribble, R. E.; Tribedy, P.; Tripathy, S. K.; Trzeciak, B. A.; Tsai, O. D.; Ullrich, T.; Underwood, D. G.; Upsal, I.; van Buren, G.; van Nieuwenhuizen, G.; Vandenbroucke, M.; Varma, R.; Vasiliev, A. N.; Vertesi, R.; Videbæk, F.; Viyogi, Y. P.; Vokal, S.; Voloshin, S. A.; Vossen, A.; Wang, G.; Wang, H.; Wang, J. S.; Wang, Y.; Wang, Y.; Wang, F.; Webb, J. C.; Webb, G.; Wen, L.; Westfall, G. D.; Wieman, H.; Wissink, S. W.; Witt, R.; Wu, Y. F.; Xiao, Z. G.; Xie, W.; Xin, K.; Xu, Y. F.; Xu, Q. H.; Xu, H.; Xu, N.; Xu, Z.; Yang, Y.; Yang, C.; Yang, S.; Yang, Y.; Yang, Q.; Ye, Z.; Yepes, P.; Yi, L.; Yip, K.; Yoo, I.-K.; Yu, N.; Zbroszczyk, H.; Zha, W.; Zhang, J. B.; Zhang, Z.; Zhang, J.; Zhang, S.; Zhang, X. P.; Zhang, J.; Zhang, Y.; Zhao, J.; Zhong, C.; Zhou, L.; Zhu, X.; Zoulkarneeva, Y.; Zyzak, M.

    2015-11-01

    One of the primary goals of nuclear physics is to understand the force between nucleons, which is a necessary step for understanding the structure of nuclei and how nuclei interact with each other. Rutherford discovered the atomic nucleus in 1911, and the large body of knowledge about the nuclear force that has since been acquired was derived from studies made on nucleons or nuclei. Although antinuclei up to antihelium-4 have been discovered and their masses measured, little is known directly about the nuclear force between antinucleons. Here, we study antiproton pair correlations among data collected by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC), where gold ions are collided with a centre-of-mass energy of 200 gigaelectronvolts per nucleon pair. Antiprotons are abundantly produced in such collisions, thus making it feasible to study details of the antiproton-antiproton interaction. By applying a technique similar to Hanbury Brown and Twiss intensity interferometry, we show that the force between two antiprotons is attractive. In addition, we report two key parameters that characterize the corresponding strong interaction: the scattering length and the effective range of the interaction. Our measured parameters are consistent within errors with the corresponding values for proton-proton interactions. Our results provide direct information on the interaction between two antiprotons, one of the simplest systems of antinucleons, and so are fundamental to understanding the structure of more-complex antinuclei and their properties.

  3. ASACUSA Anti-protonic Helium_Final

    CERN Document Server

    CERN Audiovisual Production Service; CERN AD; Paola Catapano; Julien Ordan, Arzur Catel; Paola Catapano; ASACUSA COLLABORATION

    2016-01-01

    Latest precision measurement of the mass of the proton and the anti proton though the production of antiprotonic helium by the ASACUSA experiment at CERN's antimatter factory, with a beam from the Antiproton Decelerator

  4. The Antiproton Accumulator (AA)

    CERN Multimedia

    1980-01-01

    A section of the AA where the dispersion (and hence the horizontal beam size) is large. One can distinguish (left to right): A large vacuum-tank, a quadrupole (QDN09*), a bending magnet (BST08), another vacuum-tank, a wide quadrupole (QFW08) and (in the background) a further bending magnet (BST08). The tanks are covered with heating tape for bake-out. The tank left of QDN09 contained the kickers for stochastic pre-cooling (see 790621, 8002234, 8002637X), the other one served mainly as vacuum chamber in the region where the beam was large. Peter Zettwoch works on QFW08. * see: H. Koziol, Antiproton Accumulator Parameter List, PS/AA/Note 84-2 (1984) See under 7911303, 7911597X, 8004261 and 8202324. For photos of the AA in different phases of completion (between 1979 and 1982) see: 7911303, 7911597X, 8004261, 8004608X, 8005563X, 8005565X, 8006716X, 8006722X, 8010939X, 8010941X, 8202324, 8202658X, 8203628X .

  5. Experiments on Antiprotons: Antiproton-Nucleon Cross Sections

    Science.gov (United States)

    Chamberlain, Owen; Keller, Donald V.; Mermond, Ronald; Segre, Emilio; Steiner, Herbert M.; Ypsilantis, Tom

    1957-07-22

    In this paper experiments are reported on annihilation and scattering of antiprotons in H{sub 2}O , D{sub 2}O, and O{sub 2}. From the data measured it is possible to obtain an antiproton-proton and an antiproton-deuteron cross section at 457 Mev (lab). Further analysis gives the p-p and p-n cross sections as 104 mb for the p-p reaction cross section and 113 mb for the p-n reaction cross section. The respective annihilation cross sections are 89 and 74 mb. The Glauber correction necessary in order to pass from the p-d to the p-n cross section by subtraction of the p-p cross section is unfortunately large and somewhat uncertain. The data are compared with the p-p and p-n cross sections and with other results on p-p collisions.

  6. Compression of Antiproton Clouds for Antihydrogen Trapping

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Funakoshi, R; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Hydomako, R; Jenkins, M J; Jørgensen, L V; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; Van der Werf, D P; Wurtele, J S; Yamazaki, Y

    2008-01-01

    Control of the radial profile of trapped antiproton clouds is critical to trapping antihydrogen. We report the first detailed measurements of the radial manipulation of antiproton clouds, including areal density compressions by factors as large as ten, by manipulating spatially overlapped electron plasmas. We show detailed measurements of the near-axis antiproton radial profile and its relation to that of the electron plasma.

  7. Low Energy Antiproton Ring experimental area

    CERN Multimedia

    1991-01-01

    The experimental area at the Low Energy Antiproton Ring (LEAR) is seen. This set up was used to slow down antiprotons which had been produced by colliding a proton beam with a solid target. The experiments in the hall then took antiprotons from LEAR to perform antimatter studies. One such experiment, PS210, produced the world's first antihydrogen atoms.

  8. Testing Quantum Chromodynamics with Antiprotons

    CERN Document Server

    Brodsky, S J

    2004-01-01

    The antiproton storage ring HESR to be constructed at GSI will open up a new range of perturbative and nonperturbative tests of QCD in exclusive and inclusive reactions. I discuss 21 tests of QCD using antiproton beams which can illuminate novel features of QCD. The proposed experiments include the formation of exotic hadrons, measurements of timelike generalized parton distributions, the production of charm at threshold, transversity measurements in Drell-Yan reactions, and searches for single-spin asymmetries. The interactions of antiprotons in nuclear targets will allow tests of exotic nuclear phenomena such as color transparency, hidden color, reduced nuclear amplitudes, and the non-universality of nuclear antishadowing. The AdS/CFT correspondence of large $N_C$ supergravity theory in higher-dimensional anti-de Sitter space with supersymmetric QCD in 4-dimensional space-time has important implications for hadron phenomenology in the conformal limit, including the nonperturbative derivation of counting rul...

  9. Nuclear dynamics induced by antiprotons

    CERN Document Server

    Feng, Zhao-Qing

    2015-01-01

    Reaction dynamics in collisions of antiprotons on nuclei is investigated within the Lanzhou quantum molecular dynamics model. The reaction channels of elastic scattering, annihilation, charge exchange and inelastic collisions of antiprotons on nucleons have been included in the model. Dynamics on particle production, in particular pions, kaons, antikaons and hyperons, is investigated in collisions of $\\overline{p}$ on $^{12}$C, $^{20}$Ne, $^{40}$Ca and $^{181}$Ta from a low to high incident momenta. It is found that the annihilations of $\\overline{p}$ on nucleons are of importance on the dynamics of particle production in phase space. Hyperons are mainly produced via meson induced reactions on nucleons and strangeness exchange collisions, which lead to the delayed emission in antiproton-nucleus collisions.

  10. Comparison of pencil beam–based homogeneous vs inhomogeneous target dose planning for stereotactic body radiotherapy of peripheral lung tumors through Monte Carlo–based recalculation

    Energy Technology Data Exchange (ETDEWEB)

    Ohtakara, Kazuhiro, E-mail: ohtakara@murakami.asahi-u.ac.jp [Department of Radiation Oncology, Murakami Memorial Hospital, Asahi University, Gifu (Japan); Hoshi, Hiroaki [Department of Radiology, Gifu University Graduate School of Medicine, Gifu (Japan)

    2015-10-01

    This study was conducted to ascertain whether homogeneous target dose planning is suitable for stereotactic body radiotherapy (SBRT) of peripheral lung cancer under appropriate breath-holding. For 20 peripheral lung tumors, paired dynamic conformal arc plans were generated by only adjusting the leaf margin to the planning target volume (PTV) edge for fulfilling the conditions such that the prescription isodose surface (IDS) encompassing exactly 95% of the PTV (PTV D{sub 95}) corresponds to 95% and 80% IDS, normalized to 100% at the PTV isocenter under a pencil beam (PB) algorithm with radiologic path length correction. These plans were recalculated using the x-ray voxel Monte Carlo (XVMC) algorithm under otherwise identical conditions, and then compared. Lesions abutting the parietal pleura or not were defined as edge or island tumors, respectively, and the influences of the target volume and its location relative to the chest wall on the target dose were examined. The median (range) leaf margin required for the 95% and 80% plans was 3.9 mm (1.3 to 5.0) and −1.2 mm (−1.8 to 0.1), respectively. Notably, the latter was significantly correlated negatively with PTV. In the 80% plans, the PTV D{sub 95} was slightly higher under XVMC, whereas the PTV D{sub 98} was significantly lower, irrespective of the dose calculation algorithm used. Other PTV and all gross tumor volume doses were significantly higher, while the lung doses outside the PTV were slightly lower. The target doses increased as a function of PTV and were significantly lower for island tumors than for edge tumors. In conclusion, inhomogeneous target dose planning using smaller leaf margin for a larger tumor volume was deemed suitable in ensuring more sufficient target dose while slightly reducing lung dose. In addition, more inhomogeneous target dose planning using <80% IDS (e.g., 70%) for PTV covering would be preferable for island tumors.

  11. Antiproton collisions with molecular hydrogen

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2008-01-01

    Theoretical antiproton and proton cross sections for ionization and excitation of hydrogen molecules as well as energy spectra of the ionized electrons were calculated in the impact-energy range from 8  to  4000  keV. The cross sections were computed with the close-coupling formulation of the sem......Theoretical antiproton and proton cross sections for ionization and excitation of hydrogen molecules as well as energy spectra of the ionized electrons were calculated in the impact-energy range from 8  to  4000  keV. The cross sections were computed with the close-coupling formulation...

  12. LEAR (Low Energy Antiproton Ring), general view.

    CERN Multimedia

    1990-01-01

    When the Antiproton Project was launched in the late 1970s, it was recognized that in addition to the primary purpose of high-energy proton-antiproton collisions in the SPS, there was interesting physics to be done with low-energy antiprotons. In 1982, LEAR was ready to receive antiprotons from the Antiproton Accumulator (AA), via the PS. A year later, delivery of antiprotons to the experiments began, at momenta as low as 100 MeV/c (kinetic energy 5.3 MeV), in an "Ultra-Slow Extraction" mode, dispensing some E9 antiprotons over times counted in hours. For such an achievement, stochastic and electron cooling had to be brought to high levels of perfection.

  13. Physics at CERN's Antiproton Decelerator

    CERN Document Server

    Hori, M

    2013-01-01

    The Antiproton Decelerator of CERN began operation in 1999 to serve experiments for studies of CPT invariance by precision laser and microwave spectroscopy of antihydrogen ($\\bar{\\rm H}$) and antiprotonic helium ($\\bar{p}{\\rm He}^+$). The first 12 years of operation saw cold $\\bar{\\rm H}$ synthesized by overlapping clouds of positrons ($e^+$) and antiprotons ($\\bar{p}$) confined in magnetic Penning traps. Cold $\\bar{\\rm H}$ was also produced in collisions between Rydberg positronium atoms and $\\bar{p}$. Ground-state $\\bar{\\rm H}$ was later trapped for up to $\\sim 1000$ s in a magnetic bottle trap, and microwave transitions excited between its hyperfine levels. In the $\\bar{p}{\\rm He}^+$ atom, UV transitions were measured to a precision of (2.3-5) $\\times$ $10^{-9}$ by sub-Doppler two-photon laser spectroscopy. From this the antiproton-to-electron mass ratio was determined as $M_{\\bar{p}}/m_e=$1836.1526736(23), which agrees with the p value. Microwave spectroscopy of $\\bar{p}{\\rm He}^+$ yielded a measurement o...

  14. Antiproton annihilation physics annihilation physics in the Monte Carlo particle transport code particle transport code SHIELD-HIT12A

    DEFF Research Database (Denmark)

    Taasti, Vicki Trier; Knudsen, Helge; Holzscheiter, Michael

    2015-01-01

    The Monte Carlo particle transport code SHIELD-HIT12A is designed to simulate therapeutic beams for cancer radiotherapy with fast ions. SHIELD-HIT12A allows creation of antiproton beam kernels for the treatment planning system TRiP98, but first it must be benchmarked against experimental data...

  15. Preclinical evaluation of the combination of mTOR and proteasome inhibitors with radiotherapy in malignant peripheral nerve sheath tumors.

    Science.gov (United States)

    Yamashita, A S; Baia, G S; Ho, J S Y; Velarde, E; Wong, J; Gallia, G L; Belzberg, A J; Kimura, E T; Riggins, G J

    2014-05-01

    About one half of malignant peripheral nerve sheath tumors (MPNST) have Neurofibromin 1 (NF1) mutations. NF1 is a tumor suppressor gene essential for negative regulation of RAS signaling. Survival for MPNST patients is poor and we sought to identify an effective combination therapy. Starting with the mTOR inhibitors rapamycin and everolimus, we screened for synergy in 542 FDA approved compounds using MPNST cells with a native NF1 loss in both alleles. We further analyzed the cell cycle and signal transduction. In vivo growth effects of the drug combination with local radiation therapy (RT) were assessed in MPNST xenografts. The synergistic combination of mTOR inhibitors with bortezomib yielded a reduction in MPNST cell proliferation. The combination of mTOR inhibitors and bortezomib also enhanced the anti-proliferative effect of radiation in vitro. In vivo, the combination of mTOR inhibitor (everolimus) and bortezomib with RT decreased tumor growth and proliferation, and augmented apoptosis. The combination of approved mTOR and proteasome inhibitors with radiation showed a significant reduction of tumor growth in an animal model and should be investigated and optimized further for MPNST therapy.

  16. Cosmic ray antiprotons at high energies

    Science.gov (United States)

    Winkler, Martin Wolfgang

    2017-02-01

    Cosmic ray antiprotons provide a powerful tool to probe dark matter annihilations in our galaxy. The sensitivity of this important channel is, however, diluted by sizable uncertainties in the secondary antiproton background. In this work, we improve the calculation of secondary antiproton production with a particular focus on the high energy regime. We employ the most recent collider data and identify a substantial increase of antiproton cross sections with energy. This increase is driven by the violation of Feynman scaling as well as by an enhanced strange hyperon production. The updated antiproton production cross sections are made publicly available for independent use in cosmic ray studies. In addition, we provide the correlation matrix of cross section uncertainties for the AMS-02 experiment. At high energies, the new cross sections improve the compatibility of the AMS-02 data with a pure secondary origin of antiprotons in cosmic rays.

  17. PS, septum magnet for ejection of antiprotons

    CERN Multimedia

    1980-01-01

    Antiprotons circulated in the PS in the sense opposite to that of the so far normal protons (or positive ions). A new ejection system with a new septum magnet was installed in straight section 58 for antiproton ejection, first towards the ISR and then to the principal customer, the SPS p-pbar Collider. Later on, when the PS delivered leptons for LEP, the antiproton ejection system was use for the ejection of electrons.

  18. Search for polarization effects in the antiproton production process

    CERN Document Server

    Grzonka, D; Ritman, J.; Sefzick, T.; Oelert, W.; Diermaier, M.; Widmann, E.; Zmeskal, J.; Glowacz, B.; Moskal, P.; Zielinski, M.; Wolke, M.; Nadel-Turonski, P.; Carmignotto, M.; Horn, T.; Mkrtchyan, H.; Asaturyan, A.; Mkrtchyan, A.; Tadevosyan, V.; Zhamkochyan, S.; Malbrunot-Ettenauer, S.; Eyrich, W.; Hauenstein, F.; Zink, A.

    2015-01-01

    For the production of a polarized antiproton beam various methods have been suggested including the possibility that antiprotons may be produced polarized which will be checked experimentally. The polarization of antiprotons produced under typical conditions for antiproton beam preparation will be measured at the CERN/PS. If the production process creates some polarization a polarized antiproton beam could be prepared by a rather simple modification of the antiproton beam facility. The detection setup and the expected experimental conditions are described.

  19. Assessment of Monte Carlo algorithm for compliance with RTOG 0915 dosimetric criteria in peripheral lung cancer patients treated with stereotactic body radiotherapy.

    Science.gov (United States)

    Pokhrel, Damodar; Sood, Sumit; Badkul, Rajeev; Jiang, Hongyu; McClinton, Christopher; Lominska, Christopher; Kumar, Parvesh; Wang, Fen

    2016-05-08

    The purpose of the study was to evaluate Monte Carlo-generated dose distributions with the X-ray Voxel Monte Carlo (XVMC) algorithm in the treatment of peripheral lung cancer patients using stereotactic body radiotherapy (SBRT) with non-protocol dose-volume normalization and to assess plan outcomes utilizing RTOG 0915 dosimetric compliance criteria. The Radiation Therapy Oncology Group (RTOG) protocols for non-small cell lung cancer (NSCLC) currently require radiation dose to be calculated using tissue density heterogeneity corrections. Dosimetric criteria of RTOG 0915 were established based on superposition/convolution or heterogeneities corrected pencil beam (PB-hete) algorithms for dose calculations. Clinically, more accurate Monte Carlo (MC)-based algorithms are now routinely used for lung stereotactic body radiotherapy (SBRT) dose calculations. Hence, it is important to determine whether MC calculations in the delivery of lung SBRT can achieve RTOG standards. In this report, we evaluate iPlan generated MC plans for peripheral lung cancer patients treated with SBRT using dose-volume histogram (DVH) normalization to determine if the RTOG 0915 compliance criteria can be met. This study evaluated 20 Stage I-II NSCLC patients with peripherally located lung tumors, who underwent MC-based SBRT with heterogeneity correction using X-ray Voxel Monte Carlo (XVMC) algorithm (Brainlab iPlan version 4.1.2). Total dose of 50 to 54 Gy in 3 to 5 fractions was delivered to the planning target vol-ume (PTV) with at least 95% of the PTV receiving 100% of the prescription dose (V100% ≥ 95%). The internal target volume (ITV) was delineated on maximum intensity projection (MIP) images of 4D CT scans. The PTV included the ITV plus 5 mm uniform margin applied to the ITV. The PTV ranged from 11.1 to 163.0 cc (mean = 46.1 ± 38.7 cc). Organs at risk (OARs) including ribs were delineated on mean intensity projection (MeanIP) images of 4D CT scans. Optimal clinical MC SBRT plans were

  20. The low energy atmospheric antiproton albedo

    Science.gov (United States)

    Cole, J. B.; Ormes, J. F.

    1989-01-01

    The flux of albedo antiprotons in the 100-1000 MeV kinetic energy range produced by the cosmic ray primaries in the atmosphere is calculated. It is shown that this is not a significant background to measurements of the low energy anti-proton cosmic ray flux.

  1. Antiproton radiation found effective in cancer research

    CERN Multimedia

    2003-01-01

    "An international collaboration of scientists has completed the first ever antiproton beam experiments designed to reveal the biological effectiveness of antiproton radiation in terminating cells used for cancer research...PBar Labs assembled the collaboration at CERN (European Organization for Nuclear Research in Geneva) to perform the measurements" (1 page).

  2. Status Report on the Antiproton Decelerator (AD)

    CERN Document Server

    Erikson, T; Möhl, D

    2001-01-01

    CERN's new Antiproton Decelerator (AD) has been delivering a 100 MeV/c antiproton beam to three experiments (ASACUSA, AHENA and ATRAP) since July 10th, 2000. In this status report, we summarise the initial performance of the AD, draw provisional conclusions from the first month of operation and finally give some prospects for the future.

  3. Annihilation of Antiprotons in Light Nuclei

    Institute of Scientific and Technical Information of China (English)

    M. A. Rana; E. U. Khan; M. I. Shahzad; I. E. Qureshi; F. Malik; G. Sher; S. Manzoor; H. A. Khan

    2006-01-01

    @@ CR-39 detectors have been exposed to a 5.9-MeV antiproton beam using the low energy antiproton ring (LEAR) facility at CERN. At this energy, tracks of antiprotons appear in a CR-39 detector after 135 min of etching in 6 M NaOH at 70℃ . Fluence of the antiproton beam has been determined using track density. We have also found tracks in the etched CR-39 detector at different depths (250-500μm). These tracks have resulted from the annihilation of antiprotons with the constituents (H, C and O) of the CR-39 detector. The goal of the experiment is to develop a simple and low-cost method to study properties of antiparticles and those formed after annihilation of these particles with the target matter.

  4. That was LEAP 05! or Antiproton Physics in a Nutshell

    Science.gov (United States)

    Kienle, Paul

    2005-10-01

    A personally flavored review of selected topics of LEAP 05 is given, with focus on some recent interesting developments in low and medium energy antiproton physics, such as fundamental symmetries and antihydrogen, antihadron-hadron systems, antiproton-proton annihilation, nuclear structure studies with antiprotons, and the FAIR facility for antiproton and ion research.

  5. Antiproton--Proton Scattering Experiments with Polarization

    CERN Document Server

    Lenisa, P; Lenisa, Paolo; Rathmann, Frank

    2005-01-01

    The document describes the physics case of the PAX experiment using polarized antiprotons, which has recently been proposed for the new Facility for Antiprotons and Ions Research (FAIR) at GSI--Darmstadt. Polarized antiprotons provide access to a wealth of single-- and double--spin observables, thereby opening a new window to physics uniquely accessible at the HESR. The polarized antiprotons would be most efficiently produced by spin--filtering in a dedicated Antiproton Polarizer Ring (APR) using an internal polarized hydrogen gas target. In the proposed collider scenario of the PAX experiment, polarized protons stored in a COSY--like Cooler Storage Ring (CSR) up to momenta of 3.5 GeV/c are bombarded head--on with 15 GeV/c polarized antiprotons stored in the HESR. This asymmetric double--polarized antiproton--proton collider is ideally suited to map, e.g., the transversity distribution in the proton. The proposed detector consists of a large--angle apparatus optimized for the detection of Drell--Yan electron ...

  6. High-precision spectroscopy of antiprotonic helium

    CERN Document Server

    Widmann, E

    2001-01-01

    We present first results of laser and microwave spectroscopy experiments of antiprotonic helium performed at the new Antiproton Decelerator (AD) at CERN. Extending a series of previous measurements done at the Low Energy Antiproton Ring (LEAR) of CERN, several laser- induced transitions of the antiproton in the exotic three-body system He/sup 2+/-e/sup -/-p could be determined with a precision down to 1.3*10/sup -7/. This constitutes an improvement of a factor 3 over previous measurements, and allows to test accurate three-body calculations of this system that include QED corrections. The observed agreement on the same level can be used to infer CPT limits on the antiproton charge and mass. Furthermore, a first indication of a resonance signal of a two-laser microwave triple experiment to measure the hyperfine splitting of antiprotonic helium could been observed. Such a measurement has the potential to determine the antiproton magnetic moment to a higher precision that it is known today. (19 refs).

  7. The anti-proton charge radius

    CERN Document Server

    Crivelli, P; Heiss, M W

    2016-01-01

    The upcoming operation of the Extra Low ENergy Antiprotons (ELENA) ring at CERN, the upgrade of the anti-proton decelerator (AD), and the installation in the AD hall of an intense slow positron beam with an expected flux of $10^{8}$ e$^+$/s will open the possibility for new experiments with anti-hydrogen ($\\bar{\\text{H}}$). Here we propose a scheme to measure the Lamb shift of $\\bar{\\text{H}}$. For a month of data taking, we anticipate an uncertainty of 100 ppm. This will provide a test of CPT and the first determination of the anti-proton charge radius at the level of 10%.

  8. A detector to search for antiproton decay at the Fermilab antiproton accumulator

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, T. [Pennsylvania State Univ., University Park, PA (United States); Buchanan, C.; Corbin, B.; Lindgren, M.; Muller, T.; Scott, A. [University of California at Los Angeles, Los Angeles, CA 90024 (United States); Geer, S.; Marriner, J.; Martens, M.; Ray, R.; Streets, J.; Wester, W. [Fermi National Accelerator Laboratory, Batavia, IL 60510 (United States); Gustafson, R. [University of Michigan, Ann Arbor, MI 48109 (United States); Hu, M.; Snow, G.R. [University of Nebraska-Lincoln, Lincoln, NE (United States); APEX Collaboration

    1998-07-11

    We describe the experimental apparatus used by the APEX experiment (Experiment 868) at the Fermilab antiproton accumulator. The experiment is designed to search for decays of 8.9 GeV/c antiprotons as they traverse a 3.7 m long evacuated decay tank inserted in a straight section of the antiproton accumulator ring. The detector components in the experimental set-up are discussed individually, and the performance of the experiment during data-taking is described. (orig.)

  9. Prospects for Antiproton Experiments at Fermilab

    CERN Document Server

    Kaplan, Daniel M

    2011-01-01

    Fermilab operates the world's most intense antiproton source. Newly proposed experiments can use those antiprotons either parasitically during Tevatron Collider running or after the end of the Tevatron Collider program. For example, the annihilation of 5 to 8 GeV antiprotons is expected to yield world-leading sensitivities to hyperon rare decays and CP violation. It could also provide the world's most intense source of tagged D^0 mesons, and thus the best near-term opportunity to study charm mixing and, via CP violation, to search for new physics. Other measurements that could be made include properties of the X(3872) and the charmonium system. An experiment using a Penning trap and an atom interferometer could make the world's most precise measurement of the gravitational force on antimatter. These and other potential measurements using antiprotons offer a great opportunity for a broad and exciting physics program at Fermilab in the post-Tevatron era.

  10. Antiproton Induced Fission and Fragmentation of Nuclei

    CERN Multimedia

    2002-01-01

    The annihilation of slow antiprotons with nuclei results in a large highly localized energy deposition primarily on the nuclear surface. \\\\ \\\\ The study of antiproton induced fission and fragmentation processes is expected to yield new information on special nuclear matter states, unexplored fission modes, multifragmentation of nuclei, and intranuclear cascades.\\\\ \\\\ In order to investigate the antiproton-nucleus interaction and the processes following the antiproton annihilation at the nucleus, we propose the following experiments: \\item A)~Measurement of several fragments from fission and from multifragmentation in coincidence with particle spectra, especially neutrons and kaons. \\item B)~Precise spectra of $\\pi$, K, n, p, d and t with time-of-flight techniques. \\item C)~Installation of the Berlin 4$\\pi$ neutron detector with a 4$\\pi$ Si detector placed inside for fragments and charged particles. This yields neutron multiplicity distributions and consequently distributions of thermal excitation energies and...

  11. Towards an antiproton measurement with AMS-02

    Energy Technology Data Exchange (ETDEWEB)

    Bachlechner, Andreas [RWTH Aachen University (Germany)

    2015-07-01

    AMS-02 is a multi-purpose high-precision particle detector. It has been onboard the International Space Station since May 2011. The antiprotons measurement is an important part of the AMS-02 physics program. An excess above the expected spectrum due to interactions of cosmic rays with the interstellar matter can hint at exotic sources like dark matter annihilation. The antiproton-to-proton ratio and the antiproton flux itself may also improve the understanding of the origin and propagation of cosmic rays. Due to the very small fraction of antiprotons in the cosmic radiation of about 10{sup -5} compared to protons a very precise particle identification is needed. The main backgrounds are other singly charged particles like protons, electrons, and pions produced within the detector material itself. At lower energies the ring-imaging Cherenkov detector and the time-of-flight system help to separate light particles from protons. The electromagnetic calorimeter and the transition radiation detector redundantly suppress the electron background. The reconstruction of the charge sign by the magnetic spectrometer is limited by its resolution and has to be taken into account carefully. The strategies to identify antiprotons in the cosmic-ray measurement in different energy regions are presented. Methods to suppress and the effect of the backgrounds to the antiproton-to-proton ratio are discussed.

  12. Antiproton annihilation physics in the Monte Carlo particle transport code SHIELD-HIT12A

    Energy Technology Data Exchange (ETDEWEB)

    Taasti, Vicki Trier; Knudsen, Helge [Dept. of Physics and Astronomy, Aarhus University (Denmark); Holzscheiter, Michael H. [Dept. of Physics and Astronomy, Aarhus University (Denmark); Dept. of Physics and Astronomy, University of New Mexico (United States); Sobolevsky, Nikolai [Institute for Nuclear Research of the Russian Academy of Sciences (INR), Moscow (Russian Federation); Moscow Institute of Physics and Technology (MIPT), Dolgoprudny (Russian Federation); Thomsen, Bjarne [Dept. of Physics and Astronomy, Aarhus University (Denmark); Bassler, Niels, E-mail: bassler@phys.au.dk [Dept. of Physics and Astronomy, Aarhus University (Denmark)

    2015-03-15

    The Monte Carlo particle transport code SHIELD-HIT12A is designed to simulate therapeutic beams for cancer radiotherapy with fast ions. SHIELD-HIT12A allows creation of antiproton beam kernels for the treatment planning system TRiP98, but first it must be benchmarked against experimental data. An experimental depth dose curve obtained by the AD-4/ACE collaboration was compared with an earlier version of SHIELD-HIT, but since then inelastic annihilation cross sections for antiprotons have been updated and a more detailed geometric model of the AD-4/ACE experiment was applied. Furthermore, the Fermi–Teller Z-law, which is implemented by default in SHIELD-HIT12A has been shown not to be a good approximation for the capture probability of negative projectiles by nuclei. We investigate other theories which have been developed, and give a better agreement with experimental findings. The consequence of these updates is tested by comparing simulated data with the antiproton depth dose curve in water. It is found that the implementation of these new capture probabilities results in an overestimation of the depth dose curve in the Bragg peak. This can be mitigated by scaling the antiproton collision cross sections, which restores the agreement, but some small deviations still remain. Best agreement is achieved by using the most recent antiproton collision cross sections and the Fermi–Teller Z-law, even if experimental data conclude that the Z-law is inadequately describing annihilation on compounds. We conclude that more experimental cross section data are needed in the lower energy range in order to resolve this contradiction, ideally combined with more rigorous models for annihilation on compounds.

  13. The antiproton depth–dose curve in water

    CERN Document Server

    Bassler, N; Jäkel, O; Knudsen, H V; Kovacevic, S

    2008-01-01

    We have measured the depth–dose curve of 126 MeV antiprotons in a water phantom using ionization chambers. Since the antiproton beam provided by CERN has a pulsed structure and possibly carries a high-LET component from the antiproton annihilation, it is necessary to correct the acquired charge for ion recombination effects. The results are compared with Monte Carlo calculations and were found to be in good agreement. Based on this agreement we calculate the antiproton depth–dose curve for antiprotons and compare it with that for protons and find a doubling of the physical dose in the peak region for antiprotons.

  14. Antiprotons four times more effective than protons for cell irradiation

    CERN Multimedia

    2006-01-01

    "A pioneering experiment at CERN with potential future application in cancer therapy has produced its first results. Started in 2003, ACE (Antiproton Cell Experiment) is the first investigation of the biological effects of antiprotons." (1,5 page)

  15. Antiprotons four times more effective than protons for cell irradiation

    CERN Multimedia

    2007-01-01

    "A pioneering experiment at CERN with potential future application in cancer therapy has produced its first results. Started in 2003, ACE (Antiproton Cell Experiment) is the first investigation of the biological effects of antiprotons." (1,5 page)

  16. Constraining the Higgs portal with antiprotons

    CERN Document Server

    Urbano, Alfredo

    2014-01-01

    The scalar Higgs portal is a compelling model of dark matter (DM) in which a renormalizable coupling with the Higgs boson provides the connection between the visible world and the dark sector. In this paper we investigate the constraint placed on the parameter space of this model by the antiproton data. Due to the fact that the antiproton-to-proton ratio has relative less systematic uncertainties than the antiproton absolute flux, we propose and explore the possibility to combine all the available $\\bar{p}/p$ data. Following this approach, we are able to obtain stronger limits if compared with the existing literature. In particular, we show that most of the parameter space close to the Higgs resonance is ruled out by our analysis. Furthermore, by studying the reach of the future AMS-02 antiproton and antideuteron data, we argue that a DM mass of $\\mathcal{O}(150)$ GeV offers a promising discovery potential. The method of combining all the antiproton-to-proton ratio data proposed in this paper is quite general...

  17. The Antiproton Depth-Dose Curve in Water

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael; Jäkel, Oliver

    2008-01-01

    We have measured the depth-dose curve of 126 MeV antiprotons in a water phantom using ionization chambers. Since the antiproton beam provided by CERN has a pulsed structure and possibly carries a high-LET component from the antiproton annihilation, it is necessary to correct the acquired charge...

  18. Antiproton beam polarizer using a dense polarized target

    Energy Technology Data Exchange (ETDEWEB)

    Wojtsekhowski, Bogdan

    2011-05-01

    We describe considerations regarding the spin filtering method for the antiproton beam. The proposed investigation of the double polarization cross section for antiproton to nucleon interaction is outlined. It will use a single path of the antiproton beam through a dense polarized target, e.g. 3He or CH2, followed by a polarimeter.

  19. Evaporative Cooling of Antiprotons to Cryogenic Temperatures

    CERN Document Server

    Andresen, G B; Baquero-Ruiz, M; Bertsche, W; Bowe, P D; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Friesen, T; Fujiwara, M C; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A; Hydomako, R; Jonsell, S; Kurchaninov, L; Lambo, R; Madsen, N; Menary, S; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Silveira, D M; So, C; Storey, J W; Thompson, R I; van der Werf, D P; Wilding, D; Wurtele, J S; Yamazaki, Y

    2010-01-01

    We report the application of evaporative cooling to clouds of trapped antiprotons, resulting in plasmas with measured temperature as low as 9~K. We have modeled the evaporation process for charged particles using appropriate rate equations. Good agreement between experiment and theory is observed, permitting prediction of cooling efficiency in future experiments. The technique opens up new possibilities for cooling of trapped ions and is of particular interest in antiproton physics, where a precise CPT test on trapped antihydrogen is a long-standing goal.

  20. K-shell ionization by antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Mehler, G.; Mueller, B.; Greiner, W.; Soff, G.

    1987-08-01

    We present calculations for the impact-parameter dependence of K-shell ionization rates in p-bar-Cu and in p-bar-Ag collisions at various projectile energies. We show that the effect of the attractive Coulomb potential on the Rutherford trajectory and the antibinding effect caused by the negative charge of the antiproton result in a considerable increase of the ionization probability. Total ionization cross sections for proton and antiproton projectiles are compared with each other and with experimental ionization cross sections for protons.

  1. Treatment Plans for Antiproton Beams

    DEFF Research Database (Denmark)

    Holzscheiter, Michael; Bassler, Niels; Herrmann, Rochus;

    to determine the absolute dose deposited at each depth point we are now in the position to extract relative biological efficencies (RBE) vs. depth. Using Monte Carlo calculations and various biological assays we also have studied the effect of the peripheral dose deposited as a result of the isotropic...

  2. The ASACUSA experiment at CERN's AD antiproton decelerator catches antiprotons in helium, where the antiprotons replace electrons, giving exotics atoms.

    CERN Multimedia

    Loïez, P

    2000-01-01

    Photo 03: Laser beams are prepared for shooting at antiprotonic helium atoms. Left to right: Masaki Hori (Tokyo University) and John Eades (CERN). Photo 01: Dye laser triggered by "YAG" laser. Photo 02: Masaki Hori adjusting optical system of laser beams.

  3. Three dimensional biological dose distribution of antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Tegami, Sara; Boll, Rebecca; Sellner, Stefan [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Welsch, Carsten P. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); Cockcroft Institute, University of Liverpool (United Kingdom); Holzscheiter, Michael H. [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany); University of New Mexico, Albuquerque (United States)

    2010-07-01

    The goal of external beam cancer therapy is to destroy the tumour while sparing the healthy tissue around it. In hadron therapy, the dose profile of heavy charged particles satisfies this request, because most of the energy is deposited at the end of the particle path, in the Bragg peak. Antiprotons are even more promising, thanks to the extra energy released by annihilation when captured in a normal atom at the end of range. The aim of the AD-4/ACE experiment at CERN is to determine the increase in biological dose near the Bragg peak due to densely ionizing particles emanating from the annihilation of antiprotons. Initial experiments showed the damage to cells inflicted at the end of the beam for identical damage at the skin level to be four times higher for antiprotons than for protons. The radiation field in a spread-out Bragg peak produced with antiprotons is highly mixed and for proper dose planning knowledge of linear energy transfer (LET) and relative biological efficiency (RBE) at any point in the target is needed. We are studying a number of detection methods for their response to mixed radiation fields with the goal to obtain a direct measurement of the 3D LET distribution and report on first results.

  4. Collisions of antiprotons with hydrogen molecular ions

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2009-01-01

    Time-dependent close-coupling calculations of the ionization and excitation cross section for antiproton collisions with molecular hydrogen ions are performed in an impact energy range from 0.5 keV to 10 MeV. The Born-Oppenheimer and Franck-Condon approximations as well as the impact parameter...

  5. Conceptual Design of an Antiproton Generation and Storage Facility

    Energy Technology Data Exchange (ETDEWEB)

    Peggs, Stephen

    2006-10-24

    The Antiproton Generation and Storage Facility (AGSF) creates copious quantities of antiprotons, for bottling and transportation to remote cancer therapy centers. The first step in the generation and storage process is to accelerate an intense proton beam down the Main Linac for injection into the Main Ring, which is a Rapid Cycling Synchrotron that accelerates the protons to high energy. The beam is then extracted from the ring into a transfer line and into a Proton Target. Immediately downstream of the target is an Antiproton Collector that captures some of the antiprotons and focuses them into a beam that is transported sequentially into two antiproton rings. The Precooler ring rapidly manipulates antiproton bunches from short and broad (in momentum) to long and thin. It then performs some preliminary beam cooling, in the fraction of a second before the next proton bunch is extracted from the Main Ring. Pre-cooled antiprotons are passed on to the Accumulator ring before the next antiprotons arrive from the target. The Accumulator ring cools the antiprotons, compressing them into a dense state that is convenient for mass storage over many hours. Occasionally the Accumulator ring decelerates a large number of antiprotons, injecting them into a Deceleration Linac that passes them into a waiting Penning trap.

  6. Beam position pickup for antiprotons to the ISR

    CERN Multimedia

    CERN PhotoLab

    1981-01-01

    The Antiproton Project, launched for proton-antiproton collisions in the SPS (SPS collider), had a side-line for p-pbar collisions in the ISR. A new transfer line, TT6, was constructed to transport antiprotons from the 26 GeV PS to the injection line TT1 of ISR ring 2. Antiprotons were a scarce commodity. For setting up the lines, beam diagnostic devices in the antiproton path had to work reliably and precisely with just a few low-intensity pilot pules: single bunches of about 2x10**9 antiprotons every few hours. Electrostatic pickup electrodes were used to measure beam position. They could be mounted for measurement in the horizontal plane, as in this picture, or at 90 deg, for the vertical plane.

  7. Physics at CERN’s Antiproton Decelerator

    Science.gov (United States)

    Hori, M.; Walz, J.

    2013-09-01

    The Antiproton Decelerator (AD) facility of CERN began operation in 1999 to serve experiments for studies of CPT invariance by precision laser and microwave spectroscopy of antihydrogen (Hbar ) and antiprotonic helium (pbar He) atoms. The first 12 years of AD operation saw cold Hbar synthesized by overlapping clouds of positrons (e+) and antiprotons (pbar ) confined in magnetic Penning traps. Cold Hbar was also produced in collisions between Rydberg positronium (Ps) atoms and pbar . Ground-state Hbar was later trapped for up to ˜1000 s in a magnetic bottle trap, and microwave transitions excited between its hyperfine levels. In the pbar He atom, deep ultraviolet transitions were measured to a fractional precision of (2.3-5)×10-9 by sub-Doppler two-photon laser spectroscopy. From this the antiproton-to-electron mass ratio was determined as M/me=1836.1526736(23), which agrees with the p value known to a similar precision. Microwave spectroscopy of pbar He yielded a measurement of the pbar magnetic moment with a precision of 0.3%. More recently, the magnetic moment of a single pbar confined in a Penning trap was measured with a higher precision, as μ=-2.792845(12)μ in nuclear magnetons. Other results reviewed here include the first measurements of the energy loss (-dE/dx) of 1-100 keV pbar traversing conductor and insulator targets; the cross sections of low-energy (therapy. New experiments under preparation attempt to measure the gravitational acceleration of Hbar or synthesize H. Several other future experiments will also be briefly described.

  8. Magnetic horn of the Antiproton Accumulator (AA)

    CERN Multimedia

    Photographic Service

    1988-01-01

    In the 1960s, the invention of this "current sheet lens" has helped to greatly improve the flux of neutrino beams. It was used again at the AA, collecting antiprotons from the production target at angles too large to fit into the acceptance of the AA. It was machined from aluminium to a thickness of 1.4 mm and pulsed at 400 kA for 15 microseconds (half-sine).

  9. Precision measurement of antiprotonic hydrogen and deuterium X-rays

    Science.gov (United States)

    Heitlinger, K.; Bacher, R.; Badertscher, A.; Blüm, P.; Eades, J.; Egger, J.; Elsener, K.; Gotta, D.; Morenzoni, E.; Simons, L. M.

    1992-09-01

    X-rays from antiprotonic hydrogen and deuterium have been measured at low pressures. Using the cyclotron trap, a 105 MeV/c antiproton beam from LEAR was stopped with an efficiency of 86% in 30 mbar hydrogen gas in a volume of only 100 cm3. The X-rays were measured with Si(Li) detectors and a Xe-CH4 drift chamber. The strong interaction shift and broadening of the Lyman α transition and the spin-averaged 2p width in antiprotonic hydrogen was measured with unprecedented accuracy. The triplet component of the ground state in antiprotonic hydrogen was determined for the first time.

  10. Antiproton nucleus potentials from global fits to antiprotonic X-rays and radiochemical data

    Science.gov (United States)

    Friedman, E.; Gal, A.; Mareš, J.

    2005-11-01

    We report on global fits of optical-model parameters to 90 data points for p¯ X-rays and 17 data points of radiochemical data put together. By doing separate fits to the two kinds of data it is possible to determine phenomenologically the radial region where the absorption of antiprotons takes place and to obtain neutron densities which represent the average behaviour over the periodic table. A finite-range attractive and absorptive p¯-nuclear isoscalar potential fits the data well. Self-consistent dynamical calculations within the RMF model demonstrate that the polarization of the nucleus by the atomic antiproton is negligible.

  11. Sub-ppm laser spectroscopy of antiprotonic helium and a CPT-violation limit on the antiprotonic charge and mass.

    Science.gov (United States)

    Hori, M; Eades, J; Hayano, R S; Ishikawa, T; Sakaguchi, J; Widmann, E; Yamaguchi, H; Torii, H A; Juhász, B; Horváth, D; Yamazaki, T

    2001-08-27

    Six laser-resonant transitions have been detected in metastable antiprotonic helium atoms produced at the CERN Antiproton Decelerator. They include UV transitions from the last metastable states in the v = n-l-1 = 0 and 1 cascades. Zero-density frequencies were obtained from measured pressure shifts with fractional precisions between 1.3 x 10(-7) and 1.6 x 10(-6). By comparing these with QED calculations and the antiproton cyclotron frequency, we deduce that the antiproton and proton charges and masses agree to within 6 x 10(-8) with a confidence level of 90%.

  12. Measurement of strong interaction effects in antiprotonic helium atoms

    Energy Technology Data Exchange (ETDEWEB)

    Davies, J.D.; Gorringe, T.P.; Lowe, J.; Nelson, J.M.; Playfer, S.M.; Pyle, G.J.; Squier, G.T.A. (Birmingham Univ. (UK). Dept. of Physics); Baker, C.A.; Batty, C.J.; Clark, S.A.

    1984-09-27

    The strong interaction shift and width for the 2 p level and the width for the 3d level have been measured for antiprotonic helium atoms. The results are compared with optical model calculations. The possible existence of strongly bound antiproton states in nuclei is discussed.

  13. Serach for polarization effects in the antiproton production process

    CERN Multimedia

    It is proposed to study polarization effects in the production of antiprotons at the PS test beam line T11 at 3.5 GeV/c momentum. A polarization in the production process has never been studied but if existing it would allow for a rather simple and cheap way to generate a polarized antiproton beam with the existing facilities at CERN.

  14. Progress in Antiproton Production at the Fermilab Tevatron Collider

    Energy Technology Data Exchange (ETDEWEB)

    Pasquinelli, Ralph J.; Drendel, Brian; Gollwitzer, Keith; Johnson, Stan; Lebedev, Valeri; Leveling, Anthony; Morgan, James; Nagaslaev, Vladimir; Peterson, Dave; Sondgeroth, Alan; Werkema, Steve; /Fermilab

    2009-04-01

    Fermilab Collider Run II has been ongoing since 2001. During this time peak luminosities in the Tevatron have increased from approximately 10 x 10{sup 30} cm{sup -2}sec{sup -1} to 300 x 10{sup 30} cm{sup 02}sec{sup -1}. A major contributing factor in this remarkable performance is a greatly improved antiproton production capability. Since the beginning of Run II, the average antiproton accumulation rate has increased from 2 x 10{sup 10}{anti p}/hr to about 24 x 10{sup 10}{anti p}/hr. Peak antiproton stacking rates presently exceed 28 x 10{sup 10}{anti p}/hr. The antiproton stacking rate has nearly doubled since 2005. It is this recent progress that is the focus of this paper. The process of transferring antiprotons to the Recycler Ring for subsequent transfer to the collider has been significantly restructured and streamlined, yielding additional cycle time for antiproton production. Improvements to the target station have greatly increased the antiproton yield from the production target. The performance of the Antiproton Source stochastic cooling systems has been enhanced by upgrades to the cooling electronics, accelerator lattice optimization, and improved operating procedures. In this paper, we will briefly report on each of these modifications.

  15. Antiproton impact ionization of atomic hydrogen and helium

    Energy Technology Data Exchange (ETDEWEB)

    McGovern, M; Walters, H R J [Department of Applied Mathematics and Theoretical Physics, Queen' s University, Belfast BT7 INN (United Kingdom); Assafrao, D; Mohallem, J R [Laboratorio de Atomos e Moleculas Especiais, Departamento de Fisica, ICEx, Universidade Federal de Minas Gerais, P.O Box 702, 30123-970 Belo Horizonte, MG (Brazil); Whelan, Colm T, E-mail: mmcgovern06@qub.ac.u [Department of Physics, Old Dominion University, Norfolk, VA 23529-0116 (United States)

    2009-11-01

    We shall present results for antiproton ionization of H and He ranging from fully differential cross sections to total ionization. The calculations have been made in a coupled pseudostate impact parameter approximation. It will be shown that the interaction between the antiproton and the target nucleus is very important at low energies.

  16. Detailed analysis of observed antiprotons in cosmic rays

    Directory of Open Access Journals (Sweden)

    P Davoudifar

    2009-12-01

    Full Text Available In the present work, the origin of antiprotons observed in cosmic rays (above the atmosphere is analyzed in details. We have considered the origin of the primaries, (which their interactions with the interstellar medium is one of the most important sources of antiprotons is a supernova type II then used a diffusion model for their propagation. We have used the latest parameterization for antiproton production cross section in pp collisions (instead of well known parameterization introduced by Tan et al. as well as our calculated residence time for primaries. The resulted intensity shows the secondary antiprotons produced in pp collisions in the galaxy, have a high population as one can not consider an excess for extragalactic antiprotons. Also there is a high degree of uncertainty in different parameters.

  17. Antiproton cloud compression in the ALPHA apparatus at CERN

    Energy Technology Data Exchange (ETDEWEB)

    Gutierrez, A., E-mail: andrea.gutierrez@triumf.ca [University of British Columbia, Department of Physics and Astronomy (Canada); Ashkezari, M. D. [Simon Fraser University, Department of Physics (Canada); Baquero-Ruiz, M. [University of California at Berkeley, Department of Physics (United States); Bertsche, W. [University of Manchester, School of Physics and Astronomy (United Kingdom); Burrows, C. [Swansea University, Department of Physics, College of Science (United Kingdom); Butler, E. [Centre for Cold Matter, Imperial College (United Kingdom); Capra, A. [York University, Department of Physics and Astronomy (Canada); Cesar, C. L. [Universidade Federal do Rio de Janeiro, Instituto de Física (Brazil); Charlton, M. [Swansea University, Department of Physics, College of Science (United Kingdom); Dunlop, R. [Simon Fraser University, Department of Physics (Canada); Eriksson, S. [Swansea University, Department of Physics, College of Science (United Kingdom); Evetts, N. [University of British Columbia, Department of Physics and Astronomy (Canada); Fajans, J. [University of California at Berkeley, Department of Physics (United States); Friesen, T. [Aarhus University, Department of Physics and Astronomy (Denmark); Fujiwara, M. C.; Gill, D. R. [TRIUMF (Canada); Hangst, J. S. [Aarhus University, Department of Physics and Astronomy (Denmark); Hardy, W. N. [University of British Columbia, Department of Physics and Astronomy (Canada); Hayden, M. E. [Simon Fraser University, Department of Physics (Canada); Isaac, C. A. [Swansea University, Department of Physics, College of Science (United Kingdom); and others

    2015-11-15

    We have observed a new mechanism for compression of a non-neutral plasma, where antiprotons embedded in an electron plasma are compressed by a rotating wall drive at a frequency close to the sum of the axial bounce and rotation frequencies. The radius of the antiproton cloud is reduced by up to a factor of 20 and the smallest radius measured is ∼ 0.2 mm. When the rotating wall drive is applied to either a pure electron or pure antiproton plasma, no compression is observed in the frequency range of interest. The frequency range over which compression is evident is compared to the sum of the antiproton bounce frequency and the system’s rotation frequency. It is suggested that bounce resonant transport is a likely explanation for the compression of antiproton clouds in this regime.

  18. Intensity-Frontier Antiproton Physics with The Antiproton Annihilation Spectrometer (TAPAS) at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Apollinari, Giorgio; /Fermilab; Asner, David M.; /PNL, Richland; Baldini, Wander; /INFN, Ferrara; Bartoszek, Larry; Broemmelsiek, Daniel R.; Brown, Charles N.; /Fermilab; Chakravorty, Alak; /St. Xavier U., Chicago; Colas, Paul; /Saclay; Derwent, Paul; /Fermilab; Drutskoy, Alexey; /Moscow, ITEP; Fortner, Michael; /Northern Illinois U. /Saclay /Indian Inst. Tech., Hyderabad

    2011-11-01

    The Fermilab Antiproton Source is the world's most intense source of antimatter. With the Tevatron program now behind us, this unique facility can help make the case for Fermilab's continued accelerator operations. The Antiproton Source can be used for unique, dedicated antimatter studies, including medium-energy {bar p}-annihilation experiments. We propose to assemble a powerful, yet cost-effective, solenoidal magnetic spectrometer for antiproton-annihilation events, and to use it at the Fermilab Antiproton Accumulator to measure the charm production cross section, study rare hyperon decays, search for hyperon CP asymmetry, precisely measure the properties of several charmonium and nearby states, and make the first measurements of the Drell-Yan continuum in medium-energy antiproton annihilation. Should the charm production cross section be as large as some have proposed, we will also be able to measure D{sup 0}-{bar D}{sup 0} mixing with high precision and discover (or sensitively limit) charm CP violation. The observation of charm or hyperon CP violation would be evidence for physics beyond the Standard Model, with possible implications for the origin of the baryon asymmetry of the universe - the question of what happened to all the antimatter that must have been produced in the Big Bang. The experiment will be carried out by an international collaboration and will require some four years of running time. As possibly the sole hadron experiment in progress at Fermilab during that time, it will play an important role in maintaining a broad particle physics program at Fermilab and in the U.S. It will thus help us to continue attracting creative and capable young people into science and technology, and introducing them to the important technologies of accelerators, detectors, and data acquisition and analysis - key roles in society that accelerator-based particle physics has historically played.

  19. Strangeness production in antiproton nucleus interactions

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, S. [Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.; Bonner, B.E. [Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.; Buchanan, J.A. [Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.; Carter, P. [Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.; Chan, C.S.; Clement, J.M.; Eiseman, S.E.; Empl, A.; Etkin, A.; Foley, K.J.; Hackenburg, R.W.; Hallman, T.J.; Kramer, M.A.; Lindenbaum, S.J.; Longacre, R.S.; Love, W.A.; Madansky, L.; Mattingly, A.C.; Morris, T.W.; Mutchler, G.S.; Peaslee, D.C.; Platner, E.D.; Saulys, A.C.; Toshkov, S.

    1997-06-01

    Results on the measurement of inclusive K{sub S}{sup 0}, {Lambda} and {Lambda} production cross sections and rapidity distributions for antiproton interactions on lead, copper and carbon nuclear targets at beam momenta of 5.2, 7.0 and 8.8 GeV/c are reported. Simulations employing a conventional intra-nuclear cascade model were able to reproduce the experimental results. Hence, no compelling evidence for the formation of exotic quark-gluon states of matter was found. (orig.).

  20. Radiotherapy; Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Wannenmacher, M. [Heidelberg Univ., Mannheim (Germany). Abt. fuer Klinische Radiologie; Debus, J. [Univ. Heidelberg (Germany). Abt. Radioonkologie und Strahlentherapie; Wenz, F. (eds.) [Universitaetsklinikum Mannheim (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2006-07-01

    The book is focussed on the actual knowledge on the clinical radiotherapy and radio-oncology. Besides fundamental and general contributions specific organ systems are treated in detail. The book contains the following contributions: Basic principles, radiobiological fundamentals, physical background, radiation pathology, basics and technique of brachytherapy, methodology and technique of the stereotactic radiosurgery, whole-body irradiation, operative radiotherapy, hadron therapy, hpyerthermia, combined radio-chemo-therapy, biometric clinical studies, intensity modulated radiotherapy, side effects, oncological diagnostics; central nervous system and sense organs, head-neck carcinomas, breast cancer, thorax organs, esophagus carcinoma, stomach carcinoma, pancreas carcinoma, heptabiliary cancer and liver metastases, rectal carcinomas, kidney and urinary tract, prostate carcinoma, testicular carcinoma, female pelvis, lymphatic system carcinomas, soft tissue carcinoma, skin cancer, bone metastases, pediatric tumors, nonmalignant diseases, emergency in radio-oncology, supporting therapy, palliative therapy.

  1. Laser Spectroscopy of Antiprotonic Helium Atoms

    CERN Multimedia

    2002-01-01

    %PS205 %title\\\\ \\\\Following the discovery of metastable antiprotonic helium atoms ($\\overline{p}He^{+} $) at KEK in 1991, systematic studies of their properties were made at LEAR from 1991 to 1996. In the first two years the lifetime of $\\overline{p}He^{+}$ in liquid and gaseous helium at various temperatures and pressures was measured and the effect of foreign gases on the lifetime of these atoms was investigated. Effects were also discovered which gave the antiproton a 14\\% longer lifetime in $^4$He than in $^3$He, and resulted in important differences in the shape of the annihilation time spectra in the two isotopes.\\\\ \\\\Since 1993 laser spectroscopy of the metastable $\\overline{p}He^{+}$ atoms became the main focus of PS205. Transitions were stimulated between metastable and non-metastable states of the $\\overline{p}He^{+}$ atom by firing a pulsed dye laser beam into the helium target every time an identified metastable atom was present (Figure 1). If the laser frequency matched the transition energy, the...

  2. Concept for the Antiproton Production Target at FAIR

    CERN Document Server

    Knie, K; Franzke, B; Gostishchev, V; Steck, M; Sievers, P

    2012-01-01

    This report summarizes the status of the antiproton (pbar) production area at the future FAIR (Facility for Antiproton and Ion Research) complex at GSI, Darmstadt [1]. This area is composed of the pbar production target, a magnetic horn for the collection of the pbars, and the pbar separator between target and Collector Ring (CR). The emphasis is on the optimization of the accumulation rate of antiprotons to maximize the expected peak and average luminosity for the experiment. As the doses in the target area will be very high, also radiation protection issues will be addressed.

  3. 鼻咽癌外周血单个核细胞和血浆中EB病毒DNA水平变化及与放化疗疗效的关系%The Dynamic Change of Peripheral Blood Mononuclear Cell and Plasma Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma and Correlation with the Radiotherapy and Chemotherapy Curative Effect

    Institute of Scientific and Technical Information of China (English)

    陈岩松; 陈燕; 林莺莺; 郑瑜宏

    2016-01-01

    Objective To compare the levels of peripheral blood mononuclear cell and plasma Epstein-barr virus DNA in patients with nasopharyngeal carcinoma (NPC) before and after radiotherapy and chemotherapy, and to discuss the correla-tion between the levels of EBV DNA and the short-term curative effect of the radiochemotherapy. Methods Real-time fluo-rescent quantitative PCR method were determined in 2015 July to November in fujian province tumor hospital radiotherapy was treated 75 cases of nasopharyngeal carcinoma patients before and after the radiation and chemotherapy peripheral blood mononuclear cells and plasma EBV DNA level.Compare the concentrations before and after therapy in CR、PR、SD、PD groups. The relationship was analyzed between plasma and PBMCs EBV DNA. Results CR, PR of peripheral blood mononuclear cells and plasma EBV DNA before and after treatment decreased significantly, the difference was statistically significant (P0.05). Peripheral blood mononuclear cells and plasma EBV DNA overall detection rate of 78.7%, 53.3%, obvious difference (P0.05)。外周血单个核细胞和血浆EBV DNA总体检出率为78.7%、53.3%,差异有统计学意义(P<0.05);两种类型标本EBV DNA结果呈正相关(r=0.481,P=0.00)。结论外周血单个核细胞和血浆EBV DNA检测可作为评价鼻咽癌放化疗近期疗效的指标。

  4. Conceptual designs for antiproton space propulsion systems

    Energy Technology Data Exchange (ETDEWEB)

    Cassenti, B.N.

    1989-01-01

    Five conceptual designs for antimatter space propulsion systems were compared in terms of their performance characteristics. The systems examined included solid-core liquid-propellant rockets; magnetically confined gaseous-core rockets using liquid or solid propellants; plasma-core rockets; pion rockets, which are driven directly by the mass annihilation products; and ram-augmented rockets, in which antiproton annihilation is used to heat hydrogen collected in interstellar space. It was found that, in general, as the specific impulse of the propulsion system increases, the thrust decreases. The comparison between designs showed that only fusion rockets have the capability to compete in performance with mass annihilation rockets. For very-high-speed interstellar missions, pion rockets, which can have a specific impulse of 20 million sec (although with a thrust-to-engine mass ratios of only 0.01 G) will offer best performance. 36 refs.

  5. Particle production in antiproton induced nuclear reactions

    CERN Document Server

    Feng, Zhao-Qing

    2014-01-01

    The quantum molecular dynamics model has been improved to investigate the reaction dynamics induced by antiprotons. The reaction channels of elastic scattering, annihilation, charge exchange and inelastic collisions have been included in the model. Dynamics on particle production, in particular pions, kaons, antikaons and hyperons, is investigated in collisions of $\\overline{p}$ on $^{12}$C, $^{20}$Ne, $^{40}$Ca, $^{112}$Sn, $^{181}$Ta, $^{197}$Au and $^{238}$U from a low to high incident momentum. The rapidity and momentum distributions of $\\pi^{+}$ and protons from the LEAR measurements can be well reproduced. The impacts of system size and incident momentum on particle emissions are investigated from the inclusive spectra, transverse momentum and rapidity distributions. It is found that the annihilations of $\\overline{p}$ on nucleons are of importance on the particle production. Hyperons are mainly produced via meson induced reactions on nucleons and strangeness exchange collisions when the incident moment...

  6. Fragmentation of methane molecules by antiproton impact

    Science.gov (United States)

    Salehzadeh, Arash; Kirchner, Tom

    2016-09-01

    Extending previous work for proton impact, we have investigated the fragmentation of methane molecules due to collisions with antiprotons in the 25 keV to 5 MeV impact energy range. The multi-center nature of the problem is addressed by using a spectral representation of the molecular Hartree-Fock-level Hamiltonian and a single-center expansion of the initially populated molecular orbitals. The two-center basis generator method (TC-BGM) is used for orbital propagation. Electron-removal cross sections obtained from the TC-BGM solutions are complemented with a dynamical decay-route fragmentation model to calculate cross sections for the production of fragment ions. Good agreement with the available experimental data is observed for CH4+,CH3+,CH2+and CH+. Work supported by NSERC, Canada.

  7. Precision measurement of antiprotonic hydrogen and deuterium X-rays

    Energy Technology Data Exchange (ETDEWEB)

    Heitlinger, K.; Bluem, P. (Kernforschungszentrum Karlsruhe GmbH (Germany). Inst. fuer Kernphysik Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Experimentelle Kernphysik); Bacher, R.; Badertscher, A.; Egger, J.; Morenzoni, E.; Simons, L.M. (Paul Scherrer Inst. (PSI), Villigen (Switzerland)); Eades, J.; Elsener, K. (European Organization for Nuclear Research, Geneva (Switzerland)); Gotta, D. (Forschungszentrum Juelich GmbH (Germany). Inst. fuer Kernphysik)

    1992-05-01

    X-rays from antiprotonic hydrogen and deuterium have been measured at low pressures. Using the cylcotron trap, a 105 MeV/c antiproton beam from LEAR was stopped with an efficiency of 86% in 30 mbar hydrogen gas in a volume of only 100 cm{sup 3}. The X-rays were measured with Si(Li) detectors and a Xe-CH{sub 4} drift chamber. The strong interaction shift and broadening of the Lyman {alpha} transition and the spin-averaged 2p width in antiprotonic hydrogen was measured with unprecedented accuracy. The triplet component of the ground state in antiprotonic hydrogen was determined for the first time. (orig.).

  8. The CERN Low Energy Antiproton Ring (LEAR) project

    CERN Document Server

    Lefèvre, P; Plass, G

    1980-01-01

    The idea to add to the CERN Antiproton Accumulator (AA) a facility for experiments with dense and pure beams of low energy antiprotons has received enthusiastic support from many members of the physics community. After conceptual studies done since 1977 the following scheme was authorized in May 1980: Small batches of cooled antiprotons will be skimmed off from the AA at regular intervals, decelerated in the CERN PS and transferred into a small storage ring (LEAR). In its first stage LEAR will work as a beam stretcher providing a high duty cycle spill of 10/sup 6/ p/s into an experimental area. Future options (not yet authorized) foresee internal jet targets together with cooling, co-rotating beams of p and H, proton antiproton colliding beams, fast extraction with slowing down of p's to rest. A storage ring to fulfil this variety of tasks has to combine some unusual machine features which are summarized in the present report. (6 refs).

  9. Antiproton cell experiment: antimatter is a better killer

    CERN Multimedia

    2006-01-01

    "European Organization for Nuclear Research is reporting that results from a three year study of antiprotons for neoplasm irrdiation showed a better cellular killer with a smaller lethal dose." (1,5 page)

  10. A new antiproton beam transfer scheme without coalescing

    Energy Technology Data Exchange (ETDEWEB)

    Weiren Chou et al.

    2003-06-04

    An effective way to increase the luminosity in the Fermilab Tevatron collider program Run2 is to improve the overall antiproton transfer efficiency. During antiproton coalescing in the Main Injector (MI), about 10-15% particles get lost. This loss could be avoided in a new antiproton transfer scheme that removes coalescing from the process. Moreover, this scheme would also eliminate emittance dilution due to coalescing. This scheme uses a 2.5 MHz RF system to transfer antiprotons from the Accumulator to the Main Injector. It is then followed by a bunch rotation in the MI to shorten the bunch length so that it can be captured by a 53 MHz RF bucket. Calculations and ESME simulations show that this scheme works. No new hardware is needed to implement this scheme.

  11. Antiprotons from dark matter annihilation in the Galaxy: astrophysical uncertainties

    CERN Document Server

    Evoli, Carmelo; Grasso, Dario; Maccione, Luca; Ullio, Piero

    2011-01-01

    The latest years have seen steady progresses in WIMP dark matter (DM) searches, with hints of possible signals suggested by both direct and indirect detection experiments. Antiprotons can play a key role validating those interpretations since they are copiously produced by WIMP annihilations in the Galactic halo, and the secondary antiproton background produced by Cosmic Ray (CR) interactions is predicted with fair accuracy and matches the observed spectrum very well. Using the publicly available numerical DRAGON code, we reconsider antiprotons as a tool to constrain DM models discussing its power and limitations. We provide updated constraints on a wide class of annihilating DM models by comparing our predictions against the most up-to-date ap measurements, taking also into account the latest spectral information on the p, He and other CR nuclei fluxes. Doing that, we probe carefully the uncertainties associated to both secondary and DM originated antiprotons, by using a variety of distinctively different as...

  12. Centrality dependence of antiproton production in Au+Au collisions

    Energy Technology Data Exchange (ETDEWEB)

    Beavis, D.; Bennett, M.J.; Carroll, J.B.; Chiba, J.; Chikanian, A.; Crawford, H.; Cronqvist, M.; Dardenne, Y.; Debbe, R.; Doke, T.; Engelage, J.; Greiner, L.; Hallman, T.J.; Hayano, R.S.; Heckman, H.H.; Kashiwagi, T.; Kikuchi, J.; Kumar, S.; Kuo, C.; Lindstrom, P.J.; Mitchell, J.W.; Nagamiya, S.; Nagle, J.L.; Pope, J.K.; Stankus, P.; Tanaka, K.H.; Welsh, R.C.; Zhan, W. [Brookhaven National Laboratory, Upton, New York (United States)]|[A.W. Wright Nuclear Structure Laboratory, Yale University, New Haven, Connecticut (United States)]|[University of California at Los Angeles, Los Angeles California (United States)]|[National Laboratory for High Energy Physics (KEK), Tsukuba (Japan)]|[University of California Space Sciences Laboratory, Berkeley California (United States)]|[Waseda University, Tokyo (Japan)]|[University of Tokyo, Tokyo (Japan)]|[Lawrence Berkeley Laboratory, Berkeley California (United States)]|[Universities Space Sciences Research Association/Goddard Space Flight Center, Greenbelt, Maryland (United States)]|[Nevis Laboratory, Columbia University, Irvington, New York (United States)]|[Johns Hopkins University, Baltimore, Maryland (United States); (E878 Collaboration)

    1995-11-13

    We have measured the yields of antiprotons in Au+Au interactions in the rapidity range 1.2{lt}{ital y}{lt}2.8 as a function of centrality using a beam line spectrometer. The shapes of the invariant multiplicity distributions at {ital p}{sub {ital t}}=0 are used to explore the dynamics of antiproton production and annihilation. {copyright} {ital 1995} {ital The} {ital American} {ital Physical} {ital Society}.

  13. Density shift and broadening of transition lines in antiprotonic helium

    Science.gov (United States)

    Bakalov; Jeziorski; Korona; Szalewicz; Tchoukova

    2000-03-13

    The density shift and broadening of the transition lines of antiprotonic helium have been evaluated in the impact approximation using an interatomic potential calculated ab initio with the symmetry-adapted perturbation theory. The results help to remove an uncertainty of up to 10 ppm in the laser spectroscopy data on antiprotonic helium and are of importance in experimental tests of bound state QED and CPT invariance.

  14. Heating nuclei with 8 GeV/c antiprotons

    CERN Document Server

    Lefort, T; Hsi, W C; Beaulieu, L; Viola, V E; Pienkowski, L; Korteling, R G; Leforest, R; Martin, E; Ramakrishnan, E; Rowland, D; Ruangma, A; Winchester, E M; Yennello, S J; Gushue, S; Remsberg, L P; Back, B B; Breuer, H

    1999-01-01

    Studies of the heating effect of 8 GeV/c pi sup - and antiproton beams incident on a sup 1 sup 9 sup 7 Au nucleus have been conducted at Brookhaven AGS accelerator with the Indiana Silicon Sphere 4 pi detector array. Enhanced energy deposition for antiprotons relative to negative pions and protons in this energy regime is observed. The results are consistent with predictions of an intranuclear cascade code.

  15. Postmastectomy radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Shikama, Naoto; Koguchi, Masahiko; Sasaki, Shigeru; Kaneko, Tomoki; Shinoda, Atsunori; Nishikawa, Atsushi [Shinshu Univ., Matsumoto, Nagano (Japan). School of Medicine

    2000-10-01

    Since there have been few reports on postmastectomy radiotherapy having a high evidence level in Japan, the significance of postoperative radiotherapy and the irradiation techniques were reviewed based on reports from Western countries. Authors focused on the indications for postoperative irradiation, irradiation methods (irradiation sites, irradiation techniques; prosthetics, methods of irradiating the chest wall and lymph nodes, timing of irradiation), and complications, and discuss them. The factors thought to be adaptable to postmastectomy radiotherapy have been listed. Axillary lymph node metastasis and the size of the primary focus are thought to be important factors in locoregional recurrence. The chest wall and the supraclavicular lymph nodes are the usual sites of irradiation after mastectomy. The irradiation method consists of tangential irradiation of the chest wall and single-field irradiation of the supraclavicular lymph nodes, with 46-50 Gy in fractional doses of 1.8-2 Gy x 5/w is administered for 4.5-5.5 weeks. The timing of irradiation in the West is generally after chemotherapy. Adverse radiation effects include ischemic heart disease, pneumonitis, arm edema, rib fractures, and brachial plexus paralysis. The frequency of these complications is increased by the combined use of chemotherapy or surgery. The breast cancer cure rate in Japan is generally better than in the West. It remains to be determined whether the clinical data from Europe and America are applicable to the treatment of breast cancer in Japan. To address this issue, a clinical investigation should be performed in Japan with close cooperation between surgeons, physicians, pathologists, and radiotherapists. (K.H.)

  16. Atomic Spectroscopy and Collisions Using Slow Antiprotons \\\\ ASACUSA Collaboration

    CERN Multimedia

    Matsuda, Y; Lodi-rizzini, E; Kuroda, N; Schettino, G; Hori, M; Pirkl, W; Mascagna, V; Malbrunot, C L S; Yamazaki, Y; Eades, J; Simon, M; Massiczek, O; Sauerzopf, C; Nagata, Y; Uggerhoj, U I; Mc cullough, R W; Toekesi, K M; Venturelli, L; Widmann, E; Zmeskal, J; Kanai, Y; Hayano, R; Knudsen, H; Kristiansen, H; Todoroki, K; Bartel, M A; Moller, S P; Charlton, M; Leali, M; Diermaier, M; Kolbinger, B

    2002-01-01

    ASACUSA (\\underline{A}tomic \\underline{S}pectroscopy \\underline{A}nd \\underline{C}ollisions \\underline{U}sing \\underline{S}low \\underline{A}ntiprotons) is a collaboration between a number of Japanese and European research institutions, with the goal of studying bound and continuum states of antiprotons with simple atoms.\\\\ Three phases of experimentation are planned for ASACUSA. In the first phase, we use the direct $\\overline{p}$ beam from AD at 5.3 MeV and concentrate on the laser and microwave spectroscopy of the metastable antiprotonic helium atom, $\\overline{p}$He$^+$, consisting of an electron and antiproton bound by the Coulomb force to the helium nucleus. Samples of these are readily created by bringing AD antiproton beam bunches to rest in helium gas. With the help of techniques developed at LEAR for resonating high precision laser beams with antiproton transitions in these atoms, ASACUSA achieved several of these first-phase objectives during a few short months of AD operation in 2000. Six atomic tr...

  17. The Floor's the Limit (Antiproton energies to hit new low)

    CERN Multimedia

    2000-01-01

    Celebrating the success of the RFQ in Aarhus. Left to right: Alessanda Lombardi (CERN), Iouri Bylinskii (CERN), Alex Csete (Aarhus), Ulrik Uggerhøj (Aarhus), Ryu Hayano (Tokyo, spokesman ASACUSA), Helge Knudsen (Aarhus), Werner Pirkl (CERN), Ryan Thompson (Aarhus), Søren P. Møller (Aarhus). Although in particle physics we are accustomed to strive for higher and higher energies, this is not always the most interesting thing to do with antiprotons. Indeed, as recent issues of the Bulletin have suggested, the signpost on the road to a closer look at the antiproton points towards ever-lower energies. The CERN Antiproton Decelerator decelerates antipro-tons emerging from a target placed in the path of a 26 GeV/c proton beam from 90 % of to about 10 % of the speed of light. However, even this is far too fast for many of the most interesting experiments on antiprotons planned by Danish and Japanese members of the ASACUSA collaboration. Tokyo University has therefore financed the con...

  18. Many Facets of Strangeness Nuclear Physics with Stored Antiprotons

    CERN Document Server

    Pochodzalla, Josef; Lorente, Alicia Sanchez; Rojo, Marta Martinez; Steinen, Marcell; Gerl, Jürgen; Kojouharova, Jasmina; Kojouharova, Ivan

    2016-01-01

    Stored antiprotons beams in the GeV range represent a unparalleled factory for hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of strange hadronic systems with unprecedented precision. The behavior of hyperons and -- for the first time -- of antihyperons in nuclear systems can be studied under well controlled conditions. The exclusive production of $\\Lambda\\bar{\\Lambda}$ and $\\Sigma^-\\bar{\\Lambda}$ pairs in antiproton-nucleus interactions probe the neutron and proton distribution in the nuclear periphery and will help to sample the neutron skin. For the first time, high resolution $\\gamma$-spectroscopy of doubly strange nuclei will be performed, thus complementing measurements of ground state decays of double hypernuclei with mesons beams at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange $\\Xi$-atoms are feasible and even the pr...

  19. The PANDA Experiment at FAIR - Subatomic Physics with Antiprotons

    CERN Document Server

    Messchendorp, Johan

    2016-01-01

    The non-perturbative nature of the strong interaction leads to spectacular phenomena, such as the formation of hadronic matter, color confinement, and the generation of the mass of visible matter. To get deeper insight into the underlying mechanisms remains one of the most challenging tasks within the field of subatomic physics. The antiProton ANnihilations at DArmstadt (PANDA) collaboration has the ambition to address key questions in this field by exploiting a cooled beam of antiprotons at the High Energy Storage Ring (HESR) at the future Facility for Antiproton and Ion Research (FAIR) combined with a state-of-the-art and versatile detector. This contribution will address some of the unique features of PANDA that give rise to a promising physics program together with state-of-the-art technological developments.

  20. Production of fragments and hyperfragments in antiproton-nucleus collisions

    Science.gov (United States)

    Feng, Zhao-Qing

    2016-04-01

    The formation mechanism of fragments with strangeness in collisions of antiprotons on nuclei has been investigated within the Lanzhou quantum molecular dynamics (LQMD) transport model. Production of strange particles in the antiproton-induced nuclear reactions is modeled within the LQMD model, in which all possible reaction channels such as elastic scattering, annihilation, charge exchange, and inelastic scattering in antibaryon-baryon, baryon-baryon, and meson-baryon collisions have been included. A coalescence approach is developed for constructing hyperfragments in phase space. The hyperfragments are formed within the narrower rapidities. It has the advantage of producing heavier hyperfragments and hypernuclides with strangeness s =-2 (double-Λ fragments) and s =1 (Λ ¯ fragments) in antiproton-induced reactions.

  1. Strangeness production and hypernucleus formation in antiproton induced reactions

    CERN Document Server

    Feng, Zhao-Qing

    2015-01-01

    Formation mechanism of fragments with strangeness in collisions of antiprotons on nuclei has been investigated within the Lanzhou quantum molecular dynamics (LQMD) transport approach combined with a statistical model (GEMINI) for describing the decays of excited fragments. Production of strange particles in the antiproton induced nuclear reactions is modeled within the LQMD model, in which all possible reaction channels such as elastic scattering, annihilation, charge exchange and inelastic scattering in antibaryon-baryon, baryon-baryon and meson-baryon collisions have been included. A coalescence approach is developed for constructing hyperfragments in phase space after de-excitation of nucleonic fragments. The combined approach could describe the production of fragments in low-energy antiproton induced reactions. Hyperfragments are formed within the narrower rapidities and lower kinetic energies. It has advantage to produce heavier hyperfragments and hypernuclides with strangeness s=-2 (double-$\\Lambda$ fra...

  2. Perspectives for low energy antiproton physics at FAIR

    CERN Document Server

    Widmann, Eberhard

    2014-01-01

    The CRYRING accelerator, previously located at the Manne Siegbahn Laboratory of Stockholm University, has been chosen by the FLAIR collaboration as the central accelerator for the planned facility. It has been modified to allow for high-energy injection and extraction and is capable of providing fast and slow extracted beams of antiprotons and highly charged ions. It is currently being installed at the ESR of GSI Darmstadt where it can be used with highly charged ions. The future possibilities for its use with slow antiprotons will be discussed.

  3. Calculated LET Spectrum from Antiproton Beams Stopping in Water

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael

    2009-01-01

    significantly differ from unity, which seems to warrant closer inspection of the radiobiology in this region. Monte Carlo simulations using FLUKA were performed for calculating the entire particle spectrum of a beam of 126 MeV antiprotons hitting a water phantom. In the plateau region of the simulated...... antiproton beam we observe a dose-averaged unrestricted LET of about 4 keV/μm, which is very different from the expected 0.6 keV/μm of an equivalent primary proton beam. Even though the fluence of secondaries is a magnitude less than the fluence of primary particles, the increased stopping power...

  4. High-energy antiprotons from old supernova remnants

    CERN Document Server

    Blasi, Pasquale

    2009-01-01

    A recently proposed model (arXiv:0903.2794) explains the rise in energy of the positron fraction measured by the PAMELA satellite in terms of hadronic production of positrons in aged supernova remnants, and acceleration therein. Here we present a preliminary calculation of the anti-proton flux produced by the same mechanism. While the model is consistent with present data, a rise of the antiproton to proton ratio is predicted at high energy, which strikingly distinguishes this scenario from other astrophysical explanations of the positron fraction (like pulsars). We briefly discuss important implications for Dark Matter searches via antimatter.

  5. High-energy antiprotons from old supernova remnants.

    Science.gov (United States)

    Blasi, Pasquale; Serpico, Pasquale D

    2009-08-21

    A recently proposed model explains the rise in energy of the positron fraction measured by the PAMELA satellite in terms of hadronic production of positrons in aged supernova remnants, and acceleration therein. Here we present a preliminary calculation of the antiproton flux produced by the same mechanism. While the model is consistent with present data, a rise of the antiproton to proton ratio is predicted at high energy, which strikingly distinguishes this scenario from other astrophysical explanations of the positron fraction (such as pulsars). We briefly discuss important implications for dark matter searches via antimatter.

  6. Development of narrowband lasers for spectroscopy of antiprotonic atoms

    Directory of Open Access Journals (Sweden)

    Hori M.

    2014-03-01

    Full Text Available We review some lasers developed by the ASACUSA collaboration of CERN, to carry out spectroscopy of antiprotonic helium atoms. These lasers were based on the technique of continuous-wave injection seeding of pulsed lasers. The laser output covered the wavelength regions 264–1154 nm, with peak powers of ~ 1 MW and spectral resolutions of 6–40 MHz. The devices were recently used to measure the transition frequencies of antiprotonic helium atoms to a fractional precision of several parts in ~ 109.

  7. AMS-02 antiprotons from annihilating or decaying dark matter

    Directory of Open Access Journals (Sweden)

    Koichi Hamaguchi

    2015-07-01

    Full Text Available Recently the AMS-02 experiment reported an excess of cosmic ray antiprotons over the expected astrophysical background. We interpret the excess as a signal from annihilating or decaying dark matter and find that the observed spectrum is well fitted by adding contributions from the annihilation or decay of dark matter with mass of O(TeV or larger. Interestingly, Wino dark matter with mass of around 3 TeV, whose thermal relic abundance is consistent with present dark matter abundance, can explain the antiproton excess. We also discuss the implications for the decaying gravitino dark matter with R-parity violation.

  8. Measurement of cosmic-ray antiproton spectrum at solar minimum with a long-duration balloon flight in Antarctica

    CERN Document Server

    Abe, K; Haino, S; Hams, T; Hasegawa, M; Horikoshi, A; Kim, K C; Kusumoto, A; Lee, M H; Makida, Y; Matsuda, S; Matsukawa, Y; Mitchell, J W; Nishimura, J; Nozaki, M; Orito, R; Ormes, J F; Sakai, K; Sasaki, M; Seo, E S; Shinoda, R; Streitmatter, R E; Suzuki, J; Tanaka, K; Thakur, N; Yamagami, T; Yamamoto, A; Yoshida, T; Yoshimura, K

    2011-01-01

    The energy spectrum of cosmic-ray antiprotons has been measured in the range 0.17 to 3.5 GeV, based on 7886 antiprotons collected by the BESS-Polar II instrument during a long-duration flight over Antarctica in the solar minimum period of December 2007 through January 2008. The antiproton spectrum measured by BESS-Polar II shows good consistency with secondary antiproton calculations. Cosmologically primary antiprotons have been searched for by comparing the observed and calculated antiproton spectra. The BESS-Polar II result shows no evidence of primary antiprotons originating from the evaporation of PBH.

  9. Outer casing of the AA antiproton production target

    CERN Multimedia

    1979-01-01

    The first version of the antiproton production target was a tungsten rod, 11 cm long (actually a row of 11 rods, each 1 cm long) and 3 mm in diameter. The rod was embedded in graphite, pressure-seated into an outer casing made of stainless steel. The casing had fins for forced-air cooling.

  10. The Antiproton Depth Dose Curve Measured with Alanine Detectors

    DEFF Research Database (Denmark)

    Bassler, Niels; Hansen, Johnny Witterseh; Palmans, Hugo;

    2008-01-01

    In this paper we report on the measurement of the antiproton depth dose curve, with alanine detectors. The results are compared with simulations using the particle energy spectrum calculated by FLUKA, and using the track structure model of Hansen et Olsen for conversion of calculated dose...

  11. Enhancing trappable antiproton populations through deceleration and frictional cooling

    Energy Technology Data Exchange (ETDEWEB)

    Zolotorev, Max; Sessler, Andrew; Penn, Gregory; Wurtele, Jonathan S.; Charman, Andrew E.

    2012-03-20

    CERN currently delivers antiprotons for trapping experiments with the Antiproton Decelerator (AD), which slows the antiprotons down to about 5 MeV.This energy is currently too high for direct trapping, and thick foils are used to slow down the beam to energies which can be trapped.To allow further deceleration to $\\sim 100 \\;\\mbox{keV}$, CERN is initiating the construction of ELENA,consisting of a ring which will combine RF deceleration and electron cooling capabilities. We describe a simple frictionalcooling scheme that can serve to provide significantly improved trapping efficiency, either directly from the AD or first usinga standard deceleration mechanism (induction linac or RFQ). This scheme could be implemented in a short time.The device itself is short in length, uses accessible voltages, and at reasonable cost could serve in the interim beforeELENA becomes operational, or possibly in lieu of ELENA for some experiments. Simple theory and simulations provide a preliminary assessment of theconcept and its strengths and limitations, and highlight important areas for experimental studies, in particular to pin down the level of multiplescattering for low-energy antiprotons. We show that the frictional cooling scheme can provide a similar energy spectrum to that of ELENA,but with higher transverse emittances.

  12. Beam Measurement Systems for the CERN Antiproton Decelerator (AD)

    CERN Document Server

    Angoletta, Maria Elena; Ludwig, M; Marqversen, O; Odier, P; Pedersen, F; Raich, U; Søby, L; Tranquille, G; Spickermann, T

    2001-01-01

    The new, low-energy antiproton physics facility at CERN has been successfully commissioned and has been delivering decelerated antiprotons at 100 MeV/c since July 2000. The AD consists of one ring where the 3.5 GeV/c antiprotons produced from a production target are injected, rf manipulated, stochastically cooled, decelerated (with further stages involving additional stochastic and electron cooling and rf manipulation) and extracted at 100 MeV/c. While proton test beams of sufficient intensity could be used for certain procedures in AD commissioning, this was not possible for setting-up and routine operation. Hence, special diagnostics systems had to be developed to obtain the beam and accelerator characteristics using the weak antiproton beams of a few 10E7 particles at all momenta from 3.5 GeV/c down to 100 MeV/c. These include systems for position measurement, intensity, beam size measurements using transverse aperture limiters and scintillators and Schottky-based tools. This paper gives an overall view of...

  13. Radiotherapy for Hodgkin lymphoma

    Energy Technology Data Exchange (ETDEWEB)

    Specht, Lena [Rigshospitalet Copenhagen Univ. (Denmark). Depts. of Oncology and Haematology; Yahalom, Joachim (eds.) [Memorial Sloan-Kettering Cancer, New York, NY (United States). Dept. of Radiation Oncology

    2011-07-01

    This book deals in detail with all aspects of the best practice in modern radiotherapy for Hodgkin lymphoma. It provides the background and rationale for the inclusion of radiotherapy in today's combined-modality approach, including special clinical situations such as Hodgkin lymphoma in children, in the pregnant patient, and in the elderly. Radiotherapy planning using state-of-the-art imaging, target definition, planning software, and treatment equipment is expounded in detail. Acute and long-term side effects of radiotherapy are analyzed, and the implications for modern radiotherapy approaches in Hodgkin lymphomas are explained. (orig.)

  14. Peripheral Neuropathy

    Science.gov (United States)

    ... can be associated with peripheral neuropathy. Metabolic and endocrine disorders impair the body’s ability to transform nutrients into ... to neuropathies as a result of chemical imbalances. Endocrine disorders that lead to hormonal imbalances can disturb normal ...

  15. Laser spectroscopy of the antiprotonic helium atom – its energy levels and state lifetimes

    CERN Document Server

    Hidetoshi, Yamaguchi

    2003-01-01

    The antiprotonic atom is a three-body exotic system consisting of an antiproton, an electron and a helium nucleus. Its surprising longevity was found and has been studied for more than 10 years. In this work, transition energies and lifetimes of this exotic atom were systematically studied by using the antiproton beam of AD(Antiproton Decelerator) facility at CERN, with an RFQ antiproton decelerator, a narrow-bandwidth laser, Cerenkov counters with fast-response photomultiplier tubes, and cryogenic helium target systems. Thirteen transition energies were determined with precisions of better than 200 ppb by a laser spectroscopy method, together with the elimination of the shift effect caused by collisions with surrounding atoms. Fifteen lifetimes (decay rates) of short-lived states were determined from the time distributions of the antiproton-annihilation signals and the resonance widths of the atomic spectral lines. The relation between the magnitude of the decay rates and the transition multipolarity was inv...

  16. Spectroscopy of antiprotonic helium atoms and its contribution to the fundamental physical constants

    CERN Document Server

    Hayano, R S

    2010-01-01

    Proceedings of the Japan Academy, Series B Vol. 86 (2010) No. 1 P 1-10 Language: Next Article http://dx.doi.org/10.2183/pjab.86.1 JST.JSTAGE/pjab/86.1 Reviews Spectroscopy of antiprotonic helium atoms and its contribution to the fundamental physical constants Ryugo S. HAYANO1) 1) Department of Physics, The University of Tokyo Released 2010/01/14 Keywords: antiproton, CERN, fundamental physical constants, laser spectroscopy Full Text PDF [1604K] Abstracts References(25) Antiprotonic helium atom, a metastable neutral system consisting of an antiproton, an electron and a helium nucleus, was serendipitously discovered, and has been studied at CERN’s antiproton decelerator facility. Its transition frequencies have recently been measured to nine digits of precision by laser spectroscopy. By comparing these experimental results with three-body QED calculations, the antiproton-to-electron massratio was determined as 1836.152674(5). This result contributed to the CODATA recommended val...

  17. X-rays from antiprotonic3He and4He

    Science.gov (United States)

    Schneider, M.; Bacher, R.; Blüm, P.; Gotta, D.; Heitlinger, K.; Kunold, W.; Rohmann, D.; Egger, J.; Simons, L. M.; Elsener, K.

    1991-06-01

    Antiprotonic X-rays from the helium isotopes have been observed at pressures of 36, 72, 375 and 600 mbar. The antiproton beam from LEAR with momenta of 309 and 202 MeV/c has been stopped at these pressures using the cyclotron trap. The X-rays were detected with Si (Li) and intrinsic Ge semiconductor detectors. Absolute X-ray yields were determined and the strong-interaction 2p shifts and the 2p and 3d broadenings measured to be ɛ2p=(-17±4) eV, Γ2p=(25±9) eV and Γ3d=(2.14 ±0.18) meV for ¯p3He and ɛ2p=(-18±2) eV, Γ2p =(45±5) eV and Γ3d=(2.36±0.10) meV for ¯p4He.

  18. Secondary electron emission in antiproton-carbon foil collisions

    Energy Technology Data Exchange (ETDEWEB)

    Komaki, K.; Yamazaki, Y.; Kuroki, K. (Inst. of Physics, Coll. of Arts and Sciences, Univ. of Tokyo (Japan)); Andersen, L.H.; Horsdal-Pedersen, E.; Hvelplund, P.; Knudsen, H.; Moeller, S.P.; Uggerhoej, E. (Inst. of Physics, Univ. of Aarhus (Denmark)); Elsener, K. (CERN, Geneva (Switzerland))

    1991-04-01

    Energy spectra of electrons emitted in the forward direction by antiproton and proton bombardments on carbon foil targets were measured in the incident energy region from 500 to 750 keV. In the spectra for antiproton impact, no sharp anticusp, which is expected in place of the cusp in the case of the proton impact, is recognized and a small bump is found at 50 eV below the cusp energy. The spectral profile in the equivelocity region, including smearing out of the anticusp, together with the energy and intensity of the bump, is consistent with a theoretical prediction for wake-riding electrons based on the classical trajectory Monte Carlo method. (orig.).

  19. Dark matter for excess of AMS-02 positrons and antiprotons

    Directory of Open Access Journals (Sweden)

    Chuan-Hung Chen

    2015-07-01

    Full Text Available We propose a dark matter explanation to simultaneously account for the excess of antiproton-to-proton and positron power spectra observed in the AMS-02 experiment while having the right dark matter relic abundance and satisfying the current direct search bounds. We extend the Higgs triplet model with a hidden gauge symmetry of SU(2X that is broken to Z3 by a quadruplet scalar field, rendering the associated gauge bosons stable weakly-interacting massive particle dark matter candidates. By coupling the complex Higgs triplet and the SU(2X quadruplet, the dark matter candidates can annihilate into triplet Higgs bosons each of which in turn decays into lepton or gauge boson final states. Such a mechanism gives rise to correct excess of positrons and antiprotons with an appropriate choice of the triplet vacuum expectation value. Besides, the model provides a link between neutrino mass and dark matter phenomenology.

  20. Antiproton beam profile measurements using Gas Electron Multipliers

    CERN Document Server

    Pinto, Serge Duarte; Spanggaard, Jens; Tranquille, Gerard

    2011-01-01

    The new beam profile measurement for the Antiproton Decelerator (AD) at CERN is based on a single Gas Electron Multiplier (GEM) with a 2D readout structure. This detector is very light, ~0.4% X_0, as required by the low energy of the antiprotons, 5.3 MeV. This overcomes the problems previously encountered with multi-wire proportional chambers (MWPC) for the same purpose, where beam interactions with the detector severely affect the obtained profiles. A prototype was installed and successfully tested in late 2010, with another five detectors now installed in the ASACUSA and AEgIS beam lines. We will provide a detailed description of the detector and discuss the results obtained. The success of these detectors in the AD makes GEM-based detectors likely candidates for upgrade of the beam profile monitors in all experimental areas at CERN. The various types of MWPC currently in use are aging and becoming increasingly difficult to maintain.

  1. A Good Statistics Study of Antiproton Interactions with Nuclei

    CERN Multimedia

    2002-01-01

    This experiment extends the study of inclusive pion production and the correlation between pions which result from hadron-nucleus collisions at intermediate and high energies to the antiproton-nucleus system. It is part of a long term systematic search for exotic nuclear phenomena. The correlation data will be used to extract, via pion interferometry, the size and coherence of the annihilation source in nuclei. In addition, the reaction @* + A @A p + A* will be studied to look for structure in the proton spectra which antiproton-nucleus bound states.\\\\ \\\\ The experimental system is based on a flexible, broad range, large acceptance (1~steradian) spectrometer which consists of an 80~cm diameter dipole magnet surrounded with detector arrays. These detectors provide momentum, energy loss, Cerenkov and time of flight information for up to ten ejectiles per event. Momentum resolution varies from 1\\% to 3\\%, depending on energy.

  2. The CERN Antiproton Collider Programme Accelerators and Accumulation Rings

    CERN Document Server

    Koziol, Heribert

    2004-01-01

    One of CERN's most daring and successful undertakings was the quest for the intermediate bosons, W and Z. In this paper, we describe the accelerator part of the venture which relied on a number of innovations: an extension of the budding method of stochastic cooling by many orders of magnitude; the construction of the Antiproton Accumulator, depending on several novel accelerator methods and technologies; major modifications to the 26 GeV PS Complex; and the radical conversion of the 300 GeV SPS, which just had started up as an accelerator, to a protonâ€"antiproton collider. The SPS Collider had to master the beamâ€"beam effect far beyond limits reached ever before and had to function in a tight symbiosis with the huge detectors UA1 and UA2.

  3. Measurement method of the antiproton gravitational mass using the single electron transistor

    Energy Technology Data Exchange (ETDEWEB)

    Bouchiat, V.; Chardin, G.; Devoret, M.H.; Esteve, D.

    1996-12-31

    We propose a non destructive method to measure the trajectory of a single antiproton in a drift tube using position sensors based on the single electron transistor. We show that this recently developed device has sufficient sensitivity to detect the electric field of a moving charged particle. Comparing the trajectories of antiprotons and H{sup -} ions could allow a reliable determination of the gravitational mass of the antiproton. (authors). 24 refs.

  4. Bubble detector measurements of a mixed radiation field from antiproton annihilation

    CERN Document Server

    Bassler, Niels; Møller, Søren Pape; Petersen, Jørgen B.; Rahbek, Dennis; Uggerhøj, Ulrik I.

    2006-01-01

    In the light of recent progress in the study of the biological potential of antiproton tumour treatment it is important to be able to characterize the neutron intensity arising from antiproton annihilation using simple, compact and reliable detectors. The intensity of fast neutrons from antiproton annihilation on polystyrene has been measured with bubble detectors and a multiplicity has been derived as well as an estimated neutron equivalent dose. Additionally the sensitivity of bubble detectors towards protons was measured.

  5. X-rays from anti-protonic hydrogen and deuterium

    Energy Technology Data Exchange (ETDEWEB)

    Gorringe, T.P.; Davies, J.D.; Lowe, J.; Nelson, J.M.; Playfer, S.M.; Pyle, G.J.; Squier, G.T.A.; Baker, C.A.; Batty, C.J.; Clark, S.A.; Kilvington, A.I.; Moir, J.; Sakamoto, S.; Welsh, R.E.; Winter, R.G.; Lingeman, E.W.A.

    1985-11-07

    Antiprotons from the LEAR facility at CERN were stopped in targets of gaseous H/sub 2/ or D/sub 2/. Yields of L X-rays were measured. K-series from anti p-p atoms were observed. The measured shift and width for the 1s level are ..delta..Esub(1s)=-0.73+-0.15 keV and GAMMAsub(1s)=0.85+-0.39 keV. (orig.).

  6. Selected Papers on Low-Energy Antiprotons and Possible Applications

    Energy Technology Data Exchange (ETDEWEB)

    Noble, Robert [Fermilab

    1998-09-19

    The only realistic means by which to create a facility at Fermilab to produce large amounts of low energy antiprotons is to use resources which already exist. There is simply too little money and manpower at this point in time to generate new accelerators on a time scale before the turn of the century. Therefore, innovation is required to modify existing equipment to provide the services required by experimenters.

  7. Antiprotons from dark matter annihilation in the Galaxy. Astrophysical uncertainties

    Energy Technology Data Exchange (ETDEWEB)

    Evoli, Carmelo [Chinese Academy of Sciences, Beijing (China). National Astronomical Observatories; Cholis, Ilias; Ullio, Piero [SISSA, Sezione di Trieste (Italy); INFN, Sezione di Trieste (Italy); Grasso, Dario [INFN, Sezione di Pisa (Italy); Maccione, Luca [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2011-08-15

    The latest years have seen steady progresses in WIMP dark matter (DM) searches, with hints of possible signals suggested by both direct and indirect detection experiments. Antiprotons can play a key role validating those interpretations since they are copiously produced by WIMP annihilations in the Galactic halo, and the secondary antiproton background produced by Cosmic Ray (CR) interactions is predicted with fair accuracy and matches the observed spectrum very well. Using the publicly available numerical DRAGON code, we reconsider antiprotons as a tool to constrain DM models discussing its power and limitations. We provide updated constraints on a wide class of annihilating DM models by comparing our predictions against the most up-to-date anti p measurements, taking also into account the latest spectral information on the p, He and other CR nuclei fluxes. Doing that, we probe carefully the uncertainties associated to both secondary and DM originated antiprotons, by using a variety of distinctively different assumptions for the propagation of CRs and for the DM distribution in the Galaxy. We find that the impact of the astrophysical uncertainties on constraining the DM properties can be much stronger, up to a factor of {proportional_to}50, than the one due to uncertainties on the DM distribution ({proportional_to}2-6). Remarkably, even reducing the uncertainties on the propagation parameters derived by local observables, non-local effects can still change DM model constraints even by 50%. Nevertheless, current anti p data place tight constraints on DM models, excluding some of those suggested in connection with indirect and direct searches. Finally we discuss the power of upcoming CR spectral data from the AMS-02 observatory to drastically reduce the uncertainties discussed in this paper and estimate the expected sensitivity of this instrument to some sets of DM models. (orig.)

  8. The Production and Study of Cold Antiprotons and Antihydrogen

    Science.gov (United States)

    2015-08-03

    baryon system . A second goal is to compare the antiproton and proton charge-to-mass ratios to higher precision. All interesting comparisons of the...trap designs now being used in devices that analyze pharmaceuticals and chemical compounds. There are hundreds of scientific citations to the reports... theories (QFT) for which there is a CPT theorem if plausible assump- tions (like causality, locality and Lorentz invariance) are made. Of course

  9. Saturation of low-energy antiproton annihilation on nuclei

    Science.gov (United States)

    Gal, A.; Friedman, E.; Batty, C. J.

    2000-10-01

    Recent measurements of very low-energy (pL0, parallels the recent prediction, for /E<0, that the level widths of /p¯ atoms saturate and, hence, that /p¯ deeply bound atomic states are relatively narrow. Antiproton annihilation cross sections are calculated at pL=57 MeV//c across the periodic table, and their dependence on /Z and /A is classified and discussed with respect to the Coulomb focussing effect at very low energies.

  10. A novel antiproton radial diagnostic based on octupole induced ballistic loss

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Funakoshi, R; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jenkins, M J; Jørgensen, L V; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Page, R D; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; van der Werf, D P; Wurtele, J S; Yamazaki, Y

    2008-01-01

    We report results from a novel diagnostic that probes the outer radial profile of trapped antiproton clouds. The diagnostic allows us to determine the profile by monitoring the time-history of antiproton losses that occur as an octupole field in the antiproton confinement region is increased. We show several examples of how this diagnostic helps us to understand the radial dynamics of antiprotons in normal and nested Penning-Malmberg traps. Better understanding of these dynamics may aid current attempts to trap antihydrogen atoms.

  11. Single and double ionization of helium by fast antiproton and proton impact

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, L.H.; Hvelplund, P.; Knudsen, H.; Mo-dash-barller, S.P.; Elsener, K.; Rensfelt, K.H.; Uggerho-dash-barj, E.

    1986-10-27

    The first ion-atom--collision data obtained with antiprotons are presented. We measured the single- and double-ionization cross section for 0.5-5-MeV antiprotons and protons colliding with helium. For ion energies above --2 MeV, the single-ionization cross section is the same for protons and antiprotons. However, surprisingly, the double-ionization cross section for antiprotons is approximately a factor of 2 larger than that for protons. The present data constitute a challenge for future theoretical models of charged-particle--atom collisions.

  12. Design of 2-4 GHz Equalizers for the Antiproton Accumulator Stacktail System

    Energy Technology Data Exchange (ETDEWEB)

    Deibele, C.; /Wisconsin U., Madison

    1999-01-01

    The antiproton source at Fermilab requires storage of antiprotons during the production of antiprotons. A fundamental part of the storage process involves stochastic cooling, which requires that the frequency spectrum from the pickups has notches at the revolution frequency and harmonics of the revolution frequency of the antiprotons in the storage ring. A system has been developed for broadband notches but suffers from dispersion. The dispersion inhibits the cooling process and therefore an equalizer is required. The process for designing the equalizers is described and results shown.

  13. Time-dependent density functional calculation of the energy loss of antiprotons colliding with metallic nanoshells

    Energy Technology Data Exchange (ETDEWEB)

    Quijada, M. [Departamento de Fisica de Materiales, Facultad de Quimicas UPV/EHU, Apartado 1072, 20080 San Sebastian (Spain); Donostia International Physics Center DIPC, P. Manuel de Lardizabal 4, 20018 San Sebastian (Spain); Borisov, A.G. [Donostia International Physics Center DIPC, P. Manuel de Lardizabal 4, 20018 San Sebastian (Spain); Universite Paris-Sud, Laboratoire des Collisions Atomiques et Moleculaires (France); CNRS, UMR 8625, Laboratoire des Collisions Atomiques et Moleculaires, LCAM, Batiment 351, UPS-11, Orsay, 91405 Orsay Cedex (France); Muino, R.D. [Donostia International Physics Center DIPC, P. Manuel de Lardizabal 4, 20018 San Sebastian (Spain); Centro de Fisica de Materiales, Centro Mixto CSIC-UPV/EHU, Edificio Korta, Avenida de Tolosa 72, 20018 San Sebastian (Spain)

    2008-06-15

    Time-dependent density functional theory is used to study the interaction between antiprotons and metallic nanoshells. The ground state electronic properties of the nanoshell are obtained in the jellium approximation. The energy lost by the antiproton during the collision is calculated and compared to that suffered by antiprotons traveling in metal clusters. The resulting energy loss per unit path length of material in thin nanoshells is larger than the corresponding quantity for clusters. It is shown that the collision process can be interpreted as the antiproton crossing of two nearly bi-dimensional independent metallic systems. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  14. Interpretation of the cosmic ray positron and antiproton fluxes

    CERN Document Server

    Lipari, Paolo

    2016-01-01

    The spectral shape of cosmic ray positrons and antiprotons has been accurately measured in the broad kinetic energy range 1-350 GeV. In the higher part of this range (E > 30 GeV) the e+ and pbar are both well described by power laws with spectral indices gamma[e+] = 2.77 +-0.02 and gamma[pbar] = 2.78 +- 0.04 that are approximately equal to each other and to the spectral index of protons. In the same energy range the positron/antiproton flux ratio has the approximately constant value 2.04+-0.04, that is consistent with being equal to the ratio e_/pbar calculated for the conventional mechanism of production, where the antiparticles are created as secondaries in the inelastic interactions of primary cosmic rays with interstellar gas. The positron/antiproton ratio at lower energy is significantly higher (reaching the approximate value e+/pbar = 100 for E around 1 GeV), but in the entire energy range 1-350 GeV, the flux ratio is consistent with being equal to ratio of the production rates in the conventional mecha...

  15. Capture, Electron-Cooling and Compression of Antiprotons in a Large Penning-Trap for Physics Experiments with an Ultra-Low Energy Extracted Antiproton Beam

    CERN Multimedia

    2002-01-01

    % PS200 \\\\ \\\\The availability of ultra-low energy antiprotons is a crucial ingredient for the execution of the gravity measurements PS200. We have developed a method to provide such low energy antiprotons based on a large Penning trap (the PS200 catching trap). This system can accept a fast-extracted pulse from LEAR, reduce the energy of the antiprotons in the pulse from 5.9~MeV to several tens of kilovolts using a degrading foil, and then capture the antiprotons in a large Penning trap. These antiprotons are cooled by electrons previously admitted to the trap and are collected in a small region at the center of the trap. We have demonstrated our capability to capture up to 1~million antiprotons from LEAR in a single shot, electron cool these antiprotons, and transfer up to 95\\% of them into the inner, harmonic region. A storage time in excess of 1 hour was observed. These results have been obtained with the cryogenic trap vacuum coupled to a room temperature vacuum at about l0$ ^- ^{1} ^0 $ Torr, which is an...

  16. Modified Penning-Malmberg Trap for Storing Antiprotons

    Science.gov (United States)

    Sims, William H.; Martin, James; Lewis, Raymond

    2005-01-01

    A modified Penning-Malmberg trap that could store a small cloud of antiprotons for a relatively long time (weeks) has been developed. This trap is intended for use in research on the feasibility of contemplated future matter/antimatter-annihilation systems as propulsion sources for spacecraft on long missions. This trap is also of interest in its own right as a means of storing and manipulating antiprotons for terrestrial scientific experimentation. The use of Penning-Malmberg traps to store antiprotons is not new. What is new here is the modified trap design, which utilizes state-of-the-art radiofrequency (RF) techniques, including ones that, heretofore, have been used in radio-communication applications but not in iontrap applications. A basic Penning-Malmberg trap includes an evacuated round tube that contains or is surrounded by three or more collinear tube electrodes. A steady axial magnetic field that reaches a maximum at the geometric center of the tube is applied by an external source, and DC bias voltages that give rise to an electrostatic potential that reaches a minimum at the center are applied to the electrodes. The combination of electric and magnetic fields confines the charged particles (ions or electrons) for which it was designed to a prolate spheroidal central region. However, geometric misalignments and the diffusive cooling process prevent the steady fields of a basic Penning- Malmberg trap from confining the particles indefinitely. In the modified Penning-Malmberg trap, the loss of antiprotons is reduced or eliminated by use of a "rotating-wall" RF stabilization scheme that also heats the antiproton cloud to minimize loss by matter/antimatter annihilation. The scheme involves the superposition of a quadrupole electric field that rotates about the cylindrical axis at a suitably chosen radio frequency. The modified Penning-Malmberg trap (see Figure 1) includes several collinear sets of electrodes inside a tubular vacuum chamber. Each set

  17. View of the CERN Antiproton Decelerator (AD) and portrait of Prof. Tommy Eriksson, in charge of the AD machine.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    The Antiproton Decelerator (AD) is a storage ring at the CERN laboratory in Geneva. It started operation in 2000. It decelerates antiprotons before sending them to several experiments studying antimatter : ALPHA, ASACUSA, ATRAP and ACE.

  18. Radiotherapy of esthesioneuroblastoma. Radiotherapie beim Aesthesioneuroblastom

    Energy Technology Data Exchange (ETDEWEB)

    Strnad, V. (Erlangen-Nuernberg Univ., Erlangen (Germany). Strahlentherapeutische Klinik und Poliklinik); Grabenbauer, G.G. (Erlangen-Nuernberg Univ., Erlangen (Germany). Strahlentherapeutische Klinik und Poliklinik); Dunst, J. (Erlangen-Nuernberg Univ., Erlangen (Germany). Strahlentherapeutische Klinik und Poliklinik); Sauer, R. (Erlangen-Nuernberg Univ., Erlangen (Germany). Strahlentherapeutische Klinik und Poliklinik)

    1994-02-01

    From 1985 through 1990, twelve patients with estehesioneuroblastoma have been treated at the Department of Radiotherapy at the University of Erlangen. Two had Kadish stage A, one stage B, and nine stage C. There were seven males and five females with a mean age of 43 years. Eleven patients had combined trancranial-transbasal surgery prior to radiotherapy (five R0-, four R1-, and two patients R2-resections) and one received radiotherapy only. The dose was 12 to 60 Gy (mean 54 Gy) in 1.8 Gy to 2 Gy per fraction. 8/12 patients (67%) were locally controlled. One had progressive disease during radiotherapy after partial resection and died. Three had local recurrences, one in-field and two marginal. One patient with a local recurrence developed cervical lymph node metastases, and one locally controlled patient developed bone metastases but is alive eight years after chemotherapy plus radiotherapy for metastatic disease. The five-year-overall and recurrence-free survival was 72% and 55%, respectively. (orig./MG)

  19. Multiple collision effects on the antiproton production by high energy proton (100 GeV - 1000 GeV)

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Hiroshi; Powell, J.

    1987-01-01

    Antiproton production rates which take into account multiple collision are calculated using a simple model. Methods to reduce capture of the produced antiprotons by the target are discussed, including geometry of target and the use of a high intensity laser. Antiproton production increases substantially above 150 GeV proton incident energy. The yield increases almost linearly with incident energy, alleviating space charge problems in the high current accelerator that produces large amounts of antiprotons.

  20. Antiprotonic atom formation and spectroscopy-ASACUSA experiment at CERN-AD

    CERN Document Server

    Widmann, E

    1999-01-01

    This talk describes the experiments on atomic spectroscopy and atomic collisions as proposed by the ASACUSA collaboration for the forthcoming AD facility at CERN. They consist of high-precision spectroscopy of antiprotonic atoms, the study of anti-protonic atom formation processes, and stopping power and ionization measurements in low-pressure gases. (18 refs).

  1. Measurement of the antiproton stopping power of gold - the Barkas effect

    Science.gov (United States)

    Medenwaldt, R.; Møller, S. P.; Uggerhøj, E.; Worm, T.; Hvelplund, P.; Knudsen, H.; Elsener, K.; Morenzoni, E.

    1991-05-01

    The stopping power of gold has been measured for antiprotons in the energy range 0.2-3 MeV using a novel time-of-flight technique. The antiproton stopping power is found to be less than half the equivalent proton stopping power near the electronic stopping power maximum. In the high-energy limit the two stopping powers merge.

  2. Measurement of the antiproton stopping power of gold - the Barkas effect

    Energy Technology Data Exchange (ETDEWEB)

    Medenwaldt, R.; Moeller, S.P.; Uggerhoej, E.; Worm, T. (Inst. for Synchrotron Radiation, Aarhus Univ. (Denmark)); Hvelplund, P.; Knudsen, H. (Inst. of Physics, Univ. of Aarhus (Denmark)); Elsener, K. (CERN, Geneva (Switzerland)); Morenzoni, E. (Paul Scherrer Inst., Villigen (Switzerland))

    1991-05-06

    The stopping power of gold has been measured for antiprotons in the energy range 0.2-3 MeV using a novel time-of-flight technique. The antiproton stopping power is found to be less than half the equivalent proton stopping power near the electronic stopping power maximum. In the high-energy limit the two stopping powers merge. (orig.).

  3. Bubble detector measurements of a mixed radiation field from antiproton annihilation

    DEFF Research Database (Denmark)

    Bassler, Niels; Knudsen, Helge; Møller, Søren Pape;

    2006-01-01

    In the light of recent progress in the study of the biological potential of antiproton tumour treatment it is important to be able to characterize the neutron intensity arising from antiproton annihilation using simple, compact and reliable detectors. The intensity of fast neutrons from antiproto...

  4. Targeted tumor radiotherapy

    Directory of Open Access Journals (Sweden)

    Unak Perihan

    2002-01-01

    Full Text Available Targeted tumor radiotherapy is selectively delivery of curative doses of radiation to malignant sites. The aim of the targeted tumor radiotherapy is to use the radionuclides which have high LET particle emissions conjugated to appropriate carrier molecules. The radionuclides are selectively collected by tumor cells, depositing lethal doses to tumor cells while no admission occur to normal cells. In theory, targeted radiotherapy has several advantages over conventional radiotherapy since it allows a high radiation dose to be administered without causing normal tissue toxicity, although there are some limitations in the availability of appropriate targeting agents and in the calculations of administered doses. Therefore, for routine clinical applications more progress is still needed. In this article, the potential use of targeted tumor radiotherapy is briefly reviewed. More general aspects and considerations, such as potential radionuclides, mechanisms of tumor targeting was also outlined.

  5. Discriminating between antihydrogen and mirror-trapped antiprotons in a minimum-B trap

    CERN Document Server

    Amole, C; Ashkezari, M D; Baquero-Ruiz, M; Bertsche, W; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Deller, A; Eriksson, S; Fajans, J; Friesen, T; Fujiwara, M C; Gill, D R; Gutierrez, A; Hangst, J S; Hardy, W N; Hayden, M E; Humphries, A J; Hydomako, R; Kurchaninov, L; Jonsell, S; Madsen, N; Menary, S; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Robicheaux, F; Sarid, E; Silveira, D M; So, C; Storey, J W; Thompson, R I; van der Werf, D P; Wurtele, J S

    2012-01-01

    Recently, antihydrogen atoms were trapped at CERN in a magnetic minimum (minimum-B) trap formed by superconducting octupole and mirror magnet coils. The trapped antiatoms were detected by rapidly turning off these magnets, thereby eliminating the magnetic minimum and releasing any antiatoms contained in the trap. Once released, these antiatoms quickly hit the trap wall, whereupon the positrons and antiprotons in the antiatoms annihilated. The antiproton annihilations produce easily detected signals; we used these signals to prove that we trapped antihydrogen. However, our technique could be confounded by mirror-trapped antiprotons, which would produce seemingly-identical annihilation signals upon hitting the trap wall. In this paper, we discuss possible sources of mirror-trapped antiprotons and show that antihydrogen and antiprotons can be readily distinguished, often with the aid of applied electric fields, by analyzing the annihilation locations and times. We further discuss the general properties of antipr...

  6. Extra Low ENergy Antiproton (ELENA) ring and its Transfer Lines: Design Report

    CERN Document Server

    Alanzeau, C; Angoletta, M E; Baillie, J; Barna, D; Bartmann, W; Belochitskii, P; Borburgh, J; Breuker, H; Butin, F; Buzio, M; Capatina, O; Carli, C; Carlier, E; Cattin, M; Dobers, T; Chiggiato, P; Ducimetiere, L; Eriksson, T; Fedemann, S; Fowler, T; Froeschl, R; Gebel, R; Gilbert, N; Hancock, S; Harasimowicz, J; Hori, M; Jorgensen, L V; Kersevan, R; Kuchler, D; Lacroix, J M; LeGodec, G; Lelong, P; Lopez-Hernandez, L; Maury, S; Molendijk, J; Morand, B; Newborough, A; Nisbet, D; Nosych, A; Oelert, W; Paoluzzi, M; Pasinelli, S; Pedersen, F; Perini, D; Puccio, B; Sanchez-Quesada, J; Schoerling, D; Sermeus, L; Soby, L; Timmins, M; Tommasini, D; Tranquille, G; Vanbavinckhove, G; Vorozhtsov, A; Welsch, C; Zickler, T

    2014-01-01

    This Report gives a full description of the ELENA Ring to be built within the circumference of the Antiproton Decelarator (AD) Ring, in Building 193 at CERN. The ELENA ring will further decelerate the antiprotons coming from the AD at the momentum of 100 MeV/c down to 13.7 MeV/c, which corresponds to the kinetic energy of 100 keV before extracting to the physics experiments in the same building. The history of such an extra low energy antiproton ring at CERN goes a long way back, and even to the Decelerator’s previous incarnation, the Low Energy Antiproton Ring (LEAR), which came into operation in 1983. Already at that time, there were physics’ requests to further decelerate the antiprotons expected from LEAR by proposals for ELENA. Appendix I illustrates the cover pages of two such CERN documents from 1982.

  7. Segmented scintillation detectors with silicon photomultiplier readout for measuring antiproton annihilations

    CERN Document Server

    Sótér, A; Kobayashi, T; Barna, D; Horvath, D; Hori, M

    2014-01-01

    The Atomic Spectroscopy and Collisions Using Slow Antiprotons (ASACUSA) experiment at the Antiproton Decelerator (AD) facility of CERN constructed segmented scintillators to detect and track the charged pions which emerge from antiproton annihilations in a future superconducting radiofrequency Paul trap for antiprotons. A system of 541 cast and extruded scintillator bars were arranged in 11 detector modules which provided a spatial resolution of 17 mm. Green wavelength-shifting fibers were embedded in the scintillators, and read out by silicon photomultipliers which had a sensitive area of 1 x 1 mm^2. The photoelectron yields of various scintillator configurations were measured using a negative pion beam of momentum p ~ 1 GeV/c. Various fibers and silicon photomultipliers, fiber end terminations, and couplings between the fibers and scintillators were compared. The detectors were also tested using the antiproton beam of the AD. Nonlinear effects due to the saturation of the silicon photomultiplier were seen a...

  8. AMS results on positrons and antiprotons in cosmic rays

    Science.gov (United States)

    Kounine, Andrei; AMS Collaboration

    2017-01-01

    AMS-02 is a particle physics detector collecting data on the International Space Station since May 2011. Precision measurements of charged cosmic ray particles have been performed by AMS using a data sample of 85 billion cosmic ray events collected during the first five years of operations on the Station. The latest AMS results on the fluxes and flux ratios of the cosmic ray particles are presented with the emphasis on the measurements of positrons and antiprotons. They show unique features that require accurate theoretical interpretation as to their origin, be it from dark matter collisions or new astrophysical sources. On behalf of AMS.

  9. The antiproton depth–dose curve measured with alanine detectors

    CERN Document Server

    Bassler, Niels; Palmans, Hugo; Holzscheiter, Michael H; Kovacevic, Sandra

    2008-01-01

    n this paper we report on the measurement of the antiproton depth–dose curve, with alanine detectors. The results are compared with simulations using the particle energy spectrum calculated by FLUKA, and using the track structure model of Hansen and Olsen for conversion of calculated dose into response. A good agreement is observed between the measured and calculated relative effectiveness although an underestimation of the measured values beyond the Bragg-peak remains unexplained. The model prediction of response of alanine towards heavy charged particles encourages future use of the alanine detectors for dosimetry of mixed radiation fields.

  10. Proton-Proton and Proton-Antiproton Colliders

    Science.gov (United States)

    Scandale, Walter

    2015-02-01

    In the last five decades, proton-proton and proton-antiproton colliders have been the most powerful tools for high energy physics investigations. They have also deeply catalyzed innovation in accelerator physics and technology. Among the large number of proposed colliders, only four have really succeeded in becoming operational: the ISR, the SppbarS, the Tevatron and the LHC. Another hadron collider, RHIC, originally conceived for ion-ion collisions, has also been operated part-time with polarized protons. Although a vast literature documenting them is available, this paper is intended to provide a quick synthesis of their main features and key performance.

  11. Proton-Proton and Proton-Antiproton Colliders

    CERN Document Server

    Scandale, Walter

    2014-01-01

    In the last five decades, proton–proton and proton–antiproton colliders have been the most powerful tools for high energy physics investigations. They have also deeply catalyzed innovation in accelerator physics and technology. Among the large number of proposed colliders, only four have really succeeded in becoming operational: the ISR, the SppbarS, the Tevatron and the LHC. Another hadron collider, RHIC, originally conceived for ion–ion collisions, has also been operated part-time with polarized protons. Although a vast literature documenting them is available, this paper is intended to provide a quick synthesis of their main features and key performance.

  12. Understanding Possible Proton-Antiproton Enhancement Observed by BES Collaboration

    Institute of Scientific and Technical Information of China (English)

    GAO Chong-Shou; ZHU Shi-Lin

    2004-01-01

    We comment on the quantum numbers and decay channels of the proton-antiproton enhancement observed by BES Collaboration. Based on the general symmetry consideration and available experimental information, we suggest that the quantum number of this possible signal is very likely to be JPC = 0-+, IG = O+, which cannot decay into final states π+π-, 2π0, KK, 3π. Besides its dissociation into pp, the other important mesonic decay modes could be ηππ, η'ππ, ηηη, 4π, KKπ, ηKK, KKππ, 6π. Experimental search of this signal in these meson final states is strongly called for.

  13. FAIR: The accelerator facility for antiproton and ion research

    Energy Technology Data Exchange (ETDEWEB)

    Sharkov, Boris [FAIR JCR GSI, Darmstad (Germany)

    2010-07-01

    This presentation outlines the current status of the facility for antiproton and ion research (FAIR). It is expected that the actual construction of the facility will commence in 2010 as the project has raised more than one billion euro in funding. The sequence and scope of the construction of the accelerator modules in accordance with modularized start version are described. Outstanding research opportunities offered by the modularized start version for all scientific FAIR communities from early on will allow to bridge the time until FAIR's completion with a world-leading research program. The green paper outlining a realistic path to achieve this goal is discussed.

  14. Antiprotonic potentials from global fits to the PS209 data

    Science.gov (United States)

    Friedman, E.; Gal, A.

    2004-01-01

    The experimental results for strong interaction effects in antiprotonic atoms by the PS209 collaboration consist of high quality data for several sequences of isotopes along the periodic table. Global analysis of these data in terms of a p¯-nucleus optical potential achieves good description of the data using a s-wave finite-range p¯N interaction. Equally good fits are also obtained with a poorly-defined zero-range potential containing a p-wave term.

  15. SU-E-T-322: Dosimetric Evaluation of Rib Dose in Peripheral Lung Tumors Treated with X-Ray Voxel Monte Carlo (XVMC) Based Lung Stereotactic Body Radiotherapy (SBRT) Following RTOG 0915 Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Pokhrel, D; Sood, S; Badkul, R; Jiang, H; Kumar, P; Wang, F [University of Kansas Hospital, Kansas City, KS (United States)

    2015-06-15

    Purpose: To evaluate XVMC computed rib doses for peripherally located non-small-cell-lung tumors treated with SBRT following RTOG-0915 guidelines. Methods: Twenty patients with solitary peripherally located non-small-cell-lung tumors were treated using XVMC-based SBRT to 50–54Gy in 5−3 fractions, respectively, for PTV(V100%)=95%. Based on 4D-CT, ITV was delineated on MaximumIP images and organs-at-risk(OARs) including ribs were contoured on MeanIP images. Mean PTV(ITV+5mm uniform margin) was 46.1±38.7cc (range, 11.1–163.0cc). XVMC SBRT treatment plans were generated with a combination of non-coplanar 3D-conformal arcs/beams, and were delivered by Novalis-TX consisting of HD-MLCs and a 6MV-SRS(1000MU/min) beam, following RTOG-0915 criteria. XVMC rib maximum dose and dose to <1cc, <5cc, <10cc were evaluated as a function of PTV, prescription dose and 3D-distance from tumor isocenter to the most proximal rib contour. Plans were re-computed using heterogeneity-corrected pencil-beam (PB-hete) algorithm utilizing identical beam geometry/MLC positions and MUs and subsequently compared to XVMC. Results: XVMC average maximum rib dose was 50.9±6.4Gy (range, 35.1–59.3Gy). XVMC mean rib dose to <1cc was 41.6±5.6Gy (range, 27.9–47.9Gy), <5cc was 31.2±7.3Gy (range, 10.6–43.1Gy), and <10cc was 21.2±8.7Gy (range, 1.1–36Gy), respectively. For the given prescription, correlation between PTV and rib doses to <5cc (p=0.005) and <10cc (p=0.018) was observed. 3D-distance from the tumor isocenter to the proximal rib contour strongly correlated with maximum rib dose (p=0.0001). PB-hete algorithm overestimated maximum rib dose and dose to <1cc, <5cc, and <10cc of ribs by 5%, 3%, 3%, and 3%, respectively. Conclusion: PB-hete overestimates ribs dose relative to XVMC. Since all the clinical XVMC plans were generated without compromising the target coverage (per RTOG-0915), almost all patient’s ribs doses were higher than the protocol guidelines. As expected, larger tumor

  16. D¯ D meson pair production in antiproton-nucleus collisions

    Science.gov (United States)

    Shyam, R.; Tsushima, K.

    2016-10-01

    We study the D ¯D (D¯0D0 and D-D+) charm meson pair production in antiproton (p ¯) induced reactions on nuclei at beam energies ranging from threshold to several GeV. Our model is based on an effective Lagrangian approach that has only the baryon-meson degrees of freedom and involves the physical hadron masses. The reaction proceeds via the t -channel exchanges of Λc+, Σc+, and Σc++ baryons in the initial collision of the antiproton with one of the protons of the target nucleus. The medium effects on the exchanged baryons are included by incorporating in the corresponding propagators, the effective charm baryon masses calculated within a quark-meson coupling (QMC) model. The wave functions of the bound proton have been determined within the QMC model as well as in a phenomenological model where they are obtained by solving the Dirac equation with appropriate scalar and vector potentials. The initial- and final-state distortion effects have been approximated by using an eikonal approximation-based procedure. Detailed numerical results are presented for total and double differential cross sections for the D¯0D0 and D-D+ production reactions on 16O and 90Zr targets. It is noted that at p ¯ beam momenta of interest to the P ¯ ANDA experiment, medium effects lead to noticeable enhancements in the charm meson production cross sections.

  17. Light meson emission in (anti)proton induced reactions

    CERN Document Server

    Kuraev, E A; Tomasi-Gustafsson, E

    2015-01-01

    Reactions induced by high energy antiprotons on proton on nuclei are accompanied with large probability by the emission of a few mesons. Interesting phenomena can be observed and QCD tests can be performed, through the detection of one or more mesons. The collinear emission from high energy (anti)proton beams of a hard pion or vector meson, can be calculated similarly to the emission of a hard photon from an electron \\cite{Kuraev:2013izz}. This is a well known process in QED, and it is called the "Quasi-Real Electron method", where the incident particle is an electron and a hard photon is emitted leaving an 'almost on shell' electron impinging on the target \\cite{Baier:1973ms}. Such process is well known as Initial State Emission (ISR) method of scanning over incident energy, and can be used, in the hadron case, to produce different kind of particles in similar kinematical conditions. In case of emission of a charged light meson, $\\pi$ or $\\rho$-meson, in proton-proton(anti-proton) collisions, the meson can b...

  18. Study of doubly strange systems using stored antiprotons

    Science.gov (United States)

    Singh, B.; Erni, W.; Krusche, B.; Steinacher, M.; Walford, N.; Liu, B.; Liu, H.; Liu, Z.; Shen, X.; Wang, C.; Zhao, J.; Albrecht, M.; Erlen, T.; Fink, M.; Heinsius, F.; Held, T.; Holtmann, T.; Jasper, S.; Keshk, I.; Koch, H.; Kopf, B.; Kuhlmann, M.; Kümmel, M.; Leiber, S.; Mikirtychyants, M.; Musiol, P.; Mustafa, A.; Pelizäus, M.; Pychy, J.; Richter, M.; Schnier, C.; Schröder, T.; Sowa, C.; Steinke, M.; Triffterer, T.; Wiedner, U.; Ball, M.; Beck, R.; Hammann, C.; Ketzer, B.; Kube, M.; Mahlberg, P.; Rossbach, M.; Schmidt, C.; Schmitz, R.; Thoma, U.; Urban, M.; Walther, D.; Wendel, C.; Wilson, A.; Bianconi, A.; Bragadireanu, M.; Caprini, M.; Pantea, D.; Patel, B.; Czyzycki, W.; Domagala, M.; Filo, G.; Jaworowski, J.; Krawczyk, M.; Lisowski, E.; Lisowski, F.; Michałek, M.; Poznański, P.; Płażek, J.; Korcyl, K.; Kozela, A.; Kulessa, P.; Lebiedowicz, P.; Pysz, K.; Schäfer, W.; Szczurek, A.; Fiutowski, T.; Idzik, M.; Mindur, B.; Przyborowski, D.; Swientek, K.; Biernat, J.; Kamys, B.; Kistryn, S.; Korcyl, G.; Krzemien, W.; Magiera, A.; Moskal, P.; Psyzniak, A.; Rudy, Z.; Salabura, P.; Smyrski, J.; Strzempek, P.; Wronska, A.; Augustin, I.; Böhm, R.; Lehmann, I.; Nicmorus Marinescu, D.; Schmitt, L.; Varentsov, V.; Al-Turany, M.; Belias, A.; Deppe, H.; Dzhygadlo, R.; Ehret, A.; Flemming, H.; Gerhardt, A.; Götzen, K.; Gromliuk, A.; Gruber, L.; Karabowicz, R.; Kliemt, R.; Krebs, M.; Kurilla, U.; Lehmann, D.; Löchner, S.; Lühning, J.; Lynen, U.; Orth, H.; Patsyuk, M.; Peters, K.; Saito, T.; Schepers, G.; Schmidt, C. J.; Schwarz, C.; Schwiening, J.; Täschner, A.; Traxler, M.; Ugur, C.; Voss, B.; Wieczorek, P.; Wilms, A.; Zühlsdorf, M.; Abazov, V. M.; Alexeev, G.; Arefiev, A.; Astakhov, V. I.; Barabanov, M. Yu.; Batyunya, B. V.; Davydov, Yu. I.; Dodokhov, V. Kh.; Efremov, A. A.; Fechtchenko, A.; Fedunov, A. G.; Galoyan, A.; Grigoryan, S.; Koshurnikov, E. K.; Lobanov, V. I.; Lobanov, Y. Yu.; Makarov, A. F.; Malinina, L. V.; Malyshev, V. L.; Olshevskiy, A.; Perevalova, E.; Piskun, A. A.; Pocheptsov, T.; Pontecorvo, G.; Rodionov, V.; Rogov, Y.; Salmin, R.; Samartsev, A.; Sapozhnikov, M. G.; Shabratova, G.; Skachkov, N. B.; Skachkova, A. N.; Strokovsky, E. A.; Suleimanov, M.; Teshev, R.; Tokmenin, V.; Uzhinsky, V.; Vodopyanov, A.; Zaporozhets, S. A.; Zhuravlev, N. I.; Zorin, A. G.; Branford, D.; Glazier, D.; Watts, D.; Böhm, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Dobbs, S.; Seth, K.; Tomaradze, A.; Xiao, T.; Bettoni, D.; Carassiti, V.; Cotta Ramusino, A.; Dalpiaz, P.; Drago, A.; Fioravanti, E.; Garzia, I.; Savriè, M.; Akishina, V.; Kisel, I.; Kozlov, G.; Pugach, M.; Zyzak, M.; Gianotti, P.; Guaraldo, C.; Lucherini, V.; Bersani, A.; Bracco, G.; Macri, M.; Parodi, R. F.; Biguenko, K.; Brinkmann, K.; Di Pietro, V.; Diehl, S.; Dormenev, V.; Drexler, P.; Düren, M.; Etzelmüller, E.; Galuska, M.; Gutz, E.; Hahn, C.; Hayrapetyan, A.; Kesselkaul, M.; Kühn, W.; Kuske, T.; Lange, J. S.; Liang, Y.; Metag, V.; Nanova, M.; Nazarenko, S.; Novotny, R.; Quagli, T.; Reiter, S.; Rieke, J.; Rosenbaum, C.; Schmidt, M.; Schnell, R.; Stenzel, H.; Thöring, U.; Ullrich, M.; Wagner, M. N.; Wasem, T.; Wohlfarth, B.; Zaunick, H.; Ireland, D.; Rosner, G.; Seitz, B.; Deepak, P. N.; Kulkarni, A.; Apostolou, A.; Babai, M.; Kavatsyuk, M.; Lemmens, P.; Lindemulder, M.; Loehner, H.; Messchendorp, J.; Schakel, P.; Smit, H.; Tiemens, M.; van der Weele, J. C.; Veenstra, R.; Vejdani, S.; Dutta, K.; Kalita, K.; Kumar, A.; Roy, A.; Sohlbach, H.; Bai, M.; Bianchi, L.; Büscher, M.; Cao, L.; Cebulla, A.; Dosdall, R.; Gillitzer, A.; Goldenbaum, F.; Grunwald, D.; Herten, A.; Hu, Q.; Kemmerling, G.; Kleines, H.; Lehrach, A.; Nellen, R.; Ohm, H.; Orfanitski, S.; Prasuhn, D.; Prencipe, E.; Pütz, J.; Ritman, J.; Schadmand, S.; Sefzick, T.; Serdyuk, V.; Sterzenbach, G.; Stockmanns, T.; Wintz, P.; Wüstner, P.; Xu, H.; Zambanini, A.; Li, S.; Li, Z.; Sun, Z.; Xu, H.; Rigato, V.; Isaksson, L.; Achenbach, P.; Corell, O.; Denig, A.; Distler, M.; Hoek, M.; Karavdina, A.; Lauth, W.; Liu, Z.; Merkel, H.; Müller, U.; Pochodzalla, J.; Schlimme, S.; Sfienti, C.; Thiel, M.; Ahmadi, H.; Ahmed, S.; Bleser, S.; Capozza, L.; Cardinali, M.; Dbeyssi, A.; Deiseroth, M.; Feldbauer, F.; Fritsch, M.; Fröhlich, B.; Jasinski, P.; Kang, D.; Khaneft, D.; Klasen, R.; Leithoff, H. H.; Lin, D.; Maas, F.; Maldaner, S.; Martìnez Rojo, M.; Marta, M.; Michel, M.; Mora Espì, M. C.; Morales Morales, C.; Motzko, C.; Nerling, F.; Noll, O.; Pflüger, S.; Pitka, A.; Rodríguez Piñeiro, D.; Sanchez Lorente, A.; Steinen, M.; Valente, R.; Weber, T.; Zambrana, M.; Zimmermann, I.; Fedorov, A.; Korjik, M.; Missevitch, O.; Boukharov, A.; Malyshev, O.; Marishev, I.; Balanutsa, P.; Balanutsa, V.; Chernetsky, V.; Demekhin, A.; Dolgolenko, A.; Fedorets, P.; Gerasimov, A.

    2016-10-01

    Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an unparalleled factory for various hyperon-antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the P ‾ ANDA experiment at FAIR. For the first time, high resolution γ-spectroscopy of doubly strange ΛΛ-hypernuclei will be performed, thus complementing measurements of ground state decays of ΛΛ-hypernuclei at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange Ξ--atoms will be feasible and even the production of Ω--atoms will be within reach. The latter might open the door to the | S | = 3 world in strangeness nuclear physics, by the study of the hadronic Ω--nucleus interaction. For the first time it will be possible to study the behavior of Ξ‾+ in nuclear systems under well controlled conditions.

  19. Beam Dynamics Studies and Design Optimisation of New Low Energy Antiproton Facilities

    CERN Document Server

    Resta-Lopez, Javier; Welsch, Carsten P

    2016-01-01

    Antiprotons, stored and cooled at low energies in a storage ring or at rest in traps, are highly desirable for the investigation of a large number of basic questions on fundamental interactions. This includes the static structure of antiprotonic atomic systems and the time-dependent quantum dynamics of correlated systems. The Antiproton Decelerator (AD) at CERN is currently the worlds only low energy antiproton factory dedicated to antimatter experiments. New antiproton facilities, such as the Extra Low ENergy Antiproton ring (ELENA) at CERN and the Ultra-low energy Storage Ring (USR) at FLAIR, will open unique possibilities. They will provide cooled, high quality beams of extra-low energy antiprotons at intensities exceeding those achieved presently at the AD by factors of ten to one hundred. These facilities, operating in the energy regime between 100 keV down to 20 keV, face several design and beam dynamics challenges, for example nonlinearities, space charge and scattering effects limiting beam life time....

  20. Nanoparticle-guided radiotherapy

    DEFF Research Database (Denmark)

    2012-01-01

    The present invention relates to a method and nano-sized particles for image guided radiotherapy (IGRT) of a target tissue. More specifically, the invention relates to nano-sized particles comprising X-ray-imaging contrast agents in solid form with the ability to block x-rays, allowing for simult...... for simultaneous or integrated external beam radiotherapy and imaging, e.g., using computed tomography (CT)....

  1. Interobserver delineation variation in lung tumour stereotacticbody radiotherapy

    DEFF Research Database (Denmark)

    Persson, G. F.; Nygaard, D. E.; Hollensen, Christian;

    2012-01-01

    Objectives In radiotherapy, delineation uncertainties are important as they contribute to systematic errors and can lead to geographical miss of the target. For margin computation, standard deviations (SDs) of all uncertainties must be included as SDs. The aim of this study was to quantify...... the interobserver delineation variation for stereotactic body radiotherapy (SBRT) of peripheral lung tumours using a cross-sectional study design. Methods 22 consecutive patients with 26 tumours were included. Positron emission tomography/CT scans were acquired for planning of SBRT. Three oncologists and three...

  2. Possibility of resonant capture of antiprotons by highly charged hydrogenlike ions

    Science.gov (United States)

    Genkin, M.; Lindroth, E.

    2009-02-01

    Recently, an experimental setup was proposed by Lapierre et al. [ Physics with ultra slow antiproton beams, AIP Conference Proceedings (2005), Vol. 793, p. 361] which would allow antiprotons and highly charged ions to collide repeatedly in an electron beam ion trap (EBIT) due to a nested trap configuration. As mentioned by the authors, such a setup may open the possibility to study antiproton capture into well-defined states through a resonant process which involves simultaneous electron excitation. In the present work, we give some theoretical estimations of the feasibility of that process.

  3. Understanding Possible Proton-Antiproton Enhancement Observed by BES Collaboration

    Institute of Scientific and Technical Information of China (English)

    GAOChong-Shou; ZHUShi-Lin

    2004-01-01

    We comment on the quantum numbers and decay channels of the proton-antiproton enhancement observed by BES Collaboration. Based on the general symmetry consideration and available experimental information, we suggest that the quantum number of this possible signal is very likely to be JPC=0-+, IG=0+, which cannot decay into final states π+π-, 2π0, K/%-K,3π. Besides its dissociation into p-p, the other important mesonic decay modes could be ηππ,η'ππ,ηηη, 4π, K-Kπ,ηK-K,K-Kππ, 6π. Experimental search of this signal in these meson final states is strongly called for.

  4. Fermilab Antiproton Source, Recycler Ring, and Main Injector

    CERN Document Server

    Nagaitsev, Sergei

    2014-01-01

    At the end of its operations in 2011, the Fermilab antiproton production complex consisted of a sophisticated target system, three 8-GeV storage rings (namely the Debuncher, the Accumulator and the Recycler), 25 independent multi-GHz stochastic cooling systems, the world's only relativistic electron cooling system and a team of technical experts equal to none. The accelerator complex at Fermilab supported a broad physics program including the Tevatron Collider Run II, neutrino experiments using 8-GeV and 120-GeV proton beams, as well as a test beam facility and other fixed target experiments using 120-GeV primary proton beams. This paper provides a brief description of Fermilab accelerators as they operated at the end of the Collider Run II (2011).

  5. Antineutron and antiproton nuclear interactions at very low energies

    Science.gov (United States)

    Friedman, E.

    2014-05-01

    Experimental annihilation cross sections of antineutrons and antiprotons at very low energies are compared. Features of Coulomb focusing are observed for pbar annihilation on protons. Direct comparisons for heavier targets are not straightforward due to lack of overlap between targets and energies of experimental results for pbar and nbar. Nevertheless, the annihilation cross sections for nbar on nuclei cannot be described by an optical potential that fits well all the available data on pbar interactions with nuclei. Comparisons made with the help of this potential reveal in the nbar data features similar to Coulomb focusing. Direct comparisons between nbar and pbar annihilations at very low energies would be possible when pbar cross sections are measured on the same targets and at the same energies as the available cross sections for nbar. Such measurements may be possible in the foreseeable future.

  6. Symposium on Highlights from 14 years of LEAR Physics: "Light Antiprotonic Atoms" by R. Hayano

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years of LEAR Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  7. Experimental and computational study of the injection of antiprotons into a positron plasma for antihydrogen production

    Energy Technology Data Exchange (ETDEWEB)

    Amole, C.; Capra, A.; Menary, S. [Department of Physics and Astronomy, York University, Toronto, M3J 1P3 Ontario (Canada); Ashkezari, M. D.; Hayden, M. E. [Department of Physics, Simon Fraser University, Burnaby, V5A 1S6 British Columbia (Canada); Baquero-Ruiz, M.; Little, A.; So, C.; Zhmoginov, A. [Department of Physics, University of California, Berkeley, California 94720 (United States); Bertsche, W. [Department of Physics, College of Science, Swansea University, SA2 8PP Swansea (United Kingdom); School of Physics and Astronomy, University of Manchester, M13 9PL Manchester (United Kingdom); Daresbury Laboratory, Cockcroft Institute, WA4 4AD Warrington (United Kingdom); Butler, E. [Physics Department, CERN, CH-1211 Geneva 23 (Switzerland); Cesar, C. L.; Silveira, D. M. [Instituto de Fisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 (Brazil); Charlton, M.; Deller, A.; Eriksson, S.; Isaac, C. A.; Madsen, N.; Napoli, S. C.; Shields, C. R. [Department of Physics, College of Science, Swansea University, SA2 8PP Swansea (United Kingdom); Collaboration: ALPHA Collaboration; and others

    2013-04-15

    One of the goals of synthesizing and trapping antihydrogen is to study the validity of charge-parity-time symmetry through precision spectroscopy on the anti-atoms, but the trapping yield achieved in recent experiments must be significantly improved before this can be realized. Antihydrogen atoms are commonly produced by mixing antiprotons and positrons stored in a nested Penning-Malmberg trap, which was achieved in ALPHA by an autoresonant excitation of the antiprotons, injecting them into the positron plasma. In this work, a hybrid numerical model is developed to simulate antiproton and positron dynamics during the mixing process. The simulation is benchmarked against other numerical and analytic models, as well as experimental measurements. The autoresonant injection scheme and an alternative scheme are compared numerically over a range of plasma parameters which can be reached in current and upcoming antihydrogen experiments, and the latter scheme is seen to offer significant improvement in trapping yield as the number of available antiprotons increases.

  8. Symposium on Highlights from 14 years of LEAR Physics : "Antiproton Mass" by G. Gabrielse

    CERN Multimedia

    1998-01-01

    Symposium on Highlights from 14 years Physics hold at CERN, commemorating the closure of LEAR and giving a topical review of the impact of experiments with low energy antiprotons in their respective fields

  9. On the Utility of Antiprotons as Drivers for Inertial Confinement Fusion

    Energy Technology Data Exchange (ETDEWEB)

    Perkins, L J; Orth, C D; Tabak, M

    2003-10-20

    By contrast to the large mass, complexity and recirculating power of conventional drivers for inertial confinement fusion (ICF), antiproton annihilation offers a specific energy of 90MJ/{micro}g and thus a unique form of energy packaging and delivery. In principle, antiproton drivers could provide a profound reduction in system mass for advanced space propulsion by ICF. We examine the physics underlying the use of antiprotons ({bar p}) to drive various classes of high-yield ICF targets by the methods of volumetric ignition, hotspot ignition and fast ignition. The useable fraction of annihilation deposition energy is determined for both {bar p}-driven ablative compression and {bar p}-driven fast ignition, in association with 0-D and 1-D target burn models. Thereby, we deduce scaling laws for the number of injected antiprotons required per capsule, together with timing and focal spot requirements. The kinetic energy of the injected antiproton beam required to penetrate to the desired annihilation point is always small relative to the deposited annihilation energy. We show that heavy metal seeding of the fuel and/or ablator is required to optimize local deposition of annihilation energy and determine that a minimum of {approx}3x10{sup 15} injected antiprotons will be required to achieve high yield (several hundred megajoules) in any target configuration. Target gains - i.e., fusion yields divided by the available p - {bar p} annihilation energy from the injected antiprotons (1.88GeV/{bar p}) - range from {approx}3 for volumetric ignition targets to {approx}600 for fast ignition targets. Antiproton-driven ICF is a speculative concept, and the handling of antiprotons and their required injection precision - temporally and spatially - will present significant technical challenges. The storage and manipulation of low-energy antiprotons, particularly in the form of antihydrogen, is a science in its infancy and a large scale-up of antiproton production over present supply

  10. Antiproton, positron, and electron imaging with a microchannel plate/phosphor detector

    CERN Document Server

    Andresen, G B; Bowe, P D; Bray, C; Butler, E; Cesar, C L; Chapman, S; Charlton, M; Fajans, J; Fujiwara, M C; Gill, D R; Hangst, J S; Hardy, W N; Hayano, R S; Hayden, M E; Humphries, A J; Hydomako, R; Jørgensen, L V; Kerrigan, S J; Kurchaninov, L; Lambo, R; Madsen, N; Nolan, P; Olchanski, K; Olin, A; Povilus, A; Pusa, P; Sarid, E; Seif El Nasr, S; Silveira, D M; Storey, J W; Thompson, R I; van der Werf, D P; Yamazaki, Y

    2009-01-01

    A microchannel plate (MCP)/phosphor screen assembly has been used to destructively measure the radial profile of cold, confined antiprotons, electrons, and positrons in the ALPHA experiment, with the goal of using these trapped particles for antihydrogen creation and confinement. The response of the MCP to low energy (10-200 eV, <1 eV spread) antiproton extractions is compared to that of electrons and positrons.

  11. First measurement of the antiproton-nucleus annihilation cross section at 125 keV

    CERN Document Server

    Aghai-Khozani, H; Corradini, M; De Salvador, D; Hayano, R; Hori, M; Kobayashi, T; Leali, M; Lodi-Rizzini, E; Mascagna, V; Prest, M; Seiler, D; Soter, A; Todoroki, K; Vallazza, E; Venturelli, L

    2015-01-01

    The first observation of in-flight antiproton-nucleus annihilation at ∼130 keV obtained with the ASACUSA detector has demonstrated that the measurement of the cross section of the process is feasible at such extremely low energies Aghai-Khozani, H., et al., Eur. Phys. J. Plus 127, 55 (2012). Here we present the results of the data analysis with the evaluations of the antiproton annihilation cross sections on carbon, palladium and platinum targets at 125 keV.

  12. Primary populations of metastable antiprotonic $^{4}He$ and $^{3}He$ atoms

    CERN Document Server

    Hori, Masaki; Hayano, R S; Ishikawa, T; Sakuguchi, J; Tasaki, T; Widmann, E; Yamaguchi, H; Torii, H A; Juhász, B; Horváth, D; Yamazaki, T

    2002-01-01

    Initial population distributions of metastable antiprotonic **4He and **3He atoms over principal and angular momentum quantum numbers were investigated using laser spectroscopy. The total fractions of antiprotons captured into the metastable states of the atoms were deduced. Cascade calculations were performed using the measure populations to reproduce the delayed annihilation time spectrum. Results showed agreement between the simulated and measured spectra. (Edited abstract) 30 Refs.

  13. Study of X-Ray and $\\gamma$-Ray Spectra from Antiprotonic Atoms at the Slowly Extracted Antiproton Beam of LEAR

    CERN Multimedia

    2002-01-01

    This experiment will study the X-ray spectra of antiprotonic atoms and the $\\gamma$ spectra of residual nuclei after the antiproton absorption. We intend to begin with measurements on selected isotopically pure targets. Strong interaction effects, the antiproton absorption and the atomic cascade are analysed through the measurement of energies, lineshapes, relative and absolute intensities of all observable lines. The experiments are continued to determine st in resolved fine structure levels and in different isotopes of the same element. Coincidence techniques may be applied. All components of the experimental set-up are already existing from previous experiments and we could begin the measurements with any slowly extracted beam of low energy at LEAR.

  14. Technical design report for the PANDA (AntiProton Annihilations at Darmstadt) Straw Tube Tracker. Strong interaction studies with antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Erni, W.; Keshelashvili, I.; Krusche, B.; Steinacher, M. [Universitaet Basel, Basel (Switzerland); Heng, Y.; Liu, Z.; Liu, H.; Shen, X.; Wang, Q.; Xu, H. [Chinese Academy of Sciences, Institute of High Energy Physics, Beijing (China); Aab, A.; Albrecht, M.; Becker, J.; Csapo, A.; Feldbauer, F.; Fink, M.; Friedel, P.; Heinsius, F.H.; Held, T.; Klask, L.; Koch, H.; Kopf, B.; Leiber, S.; Leyhe, M.; Motzko, C.; Pelizaeus, M.; Pychy, J.; Roth, B.; Schroeder, T.; Schulze, J.; Sowa, C.; Steinke, M.; Trifterer, T.; Wiedner, U.; Zhong, J. [Universitaet Bochum I. Institut fuer Experimentalphysik, Bochum (Germany); Beck, R.; Bianco, S.; Brinkmann, K.T.; Hammann, C.; Hinterberger, F.; Kaiser, D.; Kliemt, R.; Kube, M.; Pitka, A.; Quagli, T.; Schmidt, C.; Schmitz, R.; Schnell, R.; Thoma, U.; Vlasov, P.; Walther, D.; Wendel, C.; Wuerschig, T.; Zaunick, H.G. [Rheinische Friedrich-Wilhelms-Universitaet Bonn, Bonn (Germany); Bianconi, A. [Universita di Brescia, Brescia (Italy); Bragadireanu, M.; Caprini, M.; Pantea, D.; Pantelica, D.; Pietreanu, D.; Serbina, L.; Tarta, P.D. [Institutul National de C and D pentru Fizica si Inginerie Nucleara ' ' Horia Hulubei' ' , Bukarest-Magurele (Romania); Kaplan, D. [IIT, Illinois Institute of Technology, Chicago (United States); Fiutowski, T.; Idzik, M.; Mindur, B.; Przyborowski, D.; Swientek, K. [AGH, University of Science and Technology, Cracow (Poland)] [and others

    2013-02-15

    This document describes the technical layout and the expected performance of the Straw Tube Tracker (STT), the main tracking detector of the PANDA target spectrometer. The STT encloses a Micro-Vertex-Detector (MVD) for the inner tracking and is followed in beam direction by a set of GEM stations. The tasks of the STT are the measurement of the particle momentum from the reconstructed trajectory and the measurement of the specific energy loss for a particle identification. Dedicated simulations with full analysis studies of certain proton-antiproton reactions, identified as being benchmark tests for the whole PANDA scientific program, have been performed to test the STT layout and performance. The results are presented, and the time lines to construct the STT are described. (orig.)

  15. Measurements of the Decays $B^0 \\to \\bar{D}^0\\proton\\antiproton$, $B^0 \\to \\bar{D}^{*0}\\proton\\antiproton$, $B^0 \\to D^{-}\\proton\\antiproton\\pi^+$, and $B^0 \\to D^{*-}\\proton\\antiproton\\pi^+$

    CERN Document Server

    Aubert, B; Bóna, M; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Pappagallo, M; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Morgan, S E; Watson, A T; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Y I; Solodov, E P; Todyshev, K Y; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Andreassen, R; Mancinelli, G; Meadows, B T; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Petzold, A; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Grenier, P; Latour, E; Thiebaux, C; Verderi, M; Bard, D J; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Gaillard, J R; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Brown, C L; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Kelly, M P; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Willocq, S Y; Cowan, R; Koeneke, K; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Patel, P M; Potter, C T; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Del Re, D; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Piccolo, D; Sciacca, C; Baak, M; Bulten, H; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Pulliam, T; Rahimi, A M; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Galeazzi, F; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Chauveau, J; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Behera, P K; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Mayer, B; Vasseur, G; Yéche, C; Zito, M; Park, W; Purohit, M V; Weidemann, A W; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Boyarski, A M; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dong, D; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Libby, J; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Vitale, L; Azzolini, V; Martínez-Vidal, F; Banerjee, S; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Eichenbaum, A M; Flood, K T; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Mellado, B; Mihályi, A; Mohapatra, A K; Pan, Y; Pierini, M; Prepost, R; Tan, P; Wu, S L; Yu, Z; Neal, H

    2006-01-01

    We present measurements of branching fractions of $B^0$ decays to multi-body final states containing protons, based on 232 million $\\Upsilon(4S)\\to B\\bar{B}$ decays collected with the BaBar detector at the SLAC PEP-II asymmetric-energy $B$ factory. We measure the branching fractions ${\\cal B}(B^0 \\to \\bar{D}^0\\proton\\antiproton)=(1.13\\pm0.06\\pm0.08)\\times 10^{-4}$, ${\\cal B}(B^0 \\to \\bar{D}^{*0}\\proton\\antiproton)=(1.01\\pm0.10\\pm0.09)\\times 10^{-4}$, ${\\cal B}(B^0 \\to D^{-}\\proton\\antiproton\\pi^+)=(3.38\\pm0.14\\pm0.29)\\times 10^{-4}$, and ${\\cal B}(B^0 \\to D^{*-}\\proton\\antiproton\\pi^+)=(4.81\\pm0.22\\pm0.44)\\times 10^{-4}$ where the first error is statistical and the second systematic. We present a search for the charmed pentaquark state, $\\Theta_c(3100)$ observed by H1 and put limits on the branching fraction ${\\cal B} (B^0 \\to \\Theta_c \\antiproton\\pi^+)\\times{\\cal B}(\\Theta_c \\to D^{*-}\\proton)<14\\times10^{-6}$ and ${\\cal B}(B^0 \\to \\Theta_c \\antiproton\\pi^+)\\times{\\cal B}(\\Theta_c\\to D^-\\proton)<9\\time...

  16. Energy and centrality dependence of antiproton and proton production in relativistic Pb+Pb collisions at the CERN SPS

    CERN Document Server

    Alt, C; Baatar, B.; Barna, D.; Bartke, J.; Betev, L.; Bialkowska, H.; Blume, C.; Boimska, B.; Botje, M.; Bracinik, J.; Bramm, R.; Buncic, P.; Cerny, V.; Christakoglou, P.; Chvala, O.; Cramer, J.G.; Csato, P.; Dinkelaker, P.; Eckardt, V.; Flierl, D.; Fodor, Z.; Foka, P.; Friese, V.; Gal, J.; Gazdzicki, M.; Genchev, V.; Georgopoulos, G.; Gladysz, E.; Grebieszkow, K.; Hegyi, S.; Hohne, C.; Kadija, K.; Karev, A.; Kliemant, M.; Kniege, S.; Kolesnikov, V.I.; Kornas, E.; Korus, R.; Kowalski, M.; Kraus, I.; Kreps, M.; Laslo, A.; van Leeuwen, M.; Levai, P.; Litov, L.; Lungwitz, B.; Makariev, M.; Malakhov, A.I.; Mateev, M.; Melkumov, G.L.; Mischke, A.; Mitrovski, M.; Molnar, J.; Mrowczynski, St.; Nicolic, V.; Palla, G.; Panagiotou, A.D.; Panayotov, D.; Petridis, A.; Pikna, M.; Prindle, D.; Puhlhofer, F.; Renfordt, R.; Roland, C.; Roland, G.; Rybczynski, M.; Rybicki, A.; Sandoval, A.; Schmitz, N.; Schuster, T.; Seyboth, P.; Sikler, F.; Sitar, B.; Skrzypczak, E.; Stefanek, G.; Stock, R.; Strabel, C.; Strobele, H.; Susa, T.; Szentpetery, I.; Sziklai, J.; Szymanski, P.; Trubnikov, V.; Varga, D.; Vassiliou, M.; Veres, G.I.; Vesztergombi, G.; Vranic, D.; Wetzler, A.; Wlodarczyk, Z.; Yoo, I.K.; Zimanyi, J.

    2005-01-01

    The transverse mass distributions for antiprotons are measured at midrapidity for minimum bias Pb+Pb collisions at 158A GeV and for central Pb+Pb collisions at 20, 30, 40 and 80 A GeV beam energies in the NA49 experiment at the CERN SPS. The rapidity density, inverse slope parameter and mean transverse mass derived from the transverse mass distributions are studied as a function of the incident energy and the collision centrality and compared to the relevant proton data. The shapes of the m_T distributions of antiprotons and protons are very similar. The ratios of the particle yields, antiproton/proton and antilambda/antiproton, are also analysed. The antiproton/proton ratio exhibits an increase with diminishing centrality and a steep rise with increasing beam energy. The antilambda/antiproton ratio increases beyond unity with decreasing beam energy.

  17. Interaction of antiprotons with Rb atoms and a comparison of antiproton stopping powers of the atoms H, Li, Na, K, and Rb

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Fischer, Nicolas; Saenz, Alejandro

    2009-01-01

    Ionization and excitation cross sections as well as electron-energy spectra and stopping powers of the alkali metal atoms Li, Na, K, and Rb colliding with antiprotons were calculated using a time-dependent channel-coupling approach. An impact-energy range from 0.25 to 4000 keV was considered....... The target atoms are treated as effective one-electron systems using a model potential. The results are compared with calculated cross sections for antiproton-hydrogen atom collisions....

  18. Radiotherapy for the medulloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Gose, Kyuhei; Imajo, Yoshinari; Imanaka, Kazufumi (Kobe Univ. (Japan). School of Medicine)

    1983-08-01

    Eighteen patients with medulloblastoma, treated between 1972 and 1981, at Kobe University School of Medicine, were retrospectively studied. Of those completing post operative irradiation, 50% have survived for 2 years, 15% for 5 years and mean survival periods was 22.2 months. 13 out of 18 patients developed local recurrence and spinal dissemination. The mean time from the initial radiotherapy to recurrence was 8.5 months. It was suggested that posterior fossa should recieve 5,000 rad, the spine should 2,000 rad and recurrences should be treated by the combination of radiotherapy and chemotherapy.

  19. Xerostomia induced by radiotherapy

    Directory of Open Access Journals (Sweden)

    Alimi D

    2015-08-01

    Full Text Available David Alimi Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USAWe read with great interest the excellent review on xerostomia induced by radiotherapy, by Pinna et al.1 The authors should be congratulated for a very detailed review of the physiopathology, clinical symptoms, and therapeutic management of an extremely difficult condition. Although we agree that the use of anticholinergic medication represents treatment, it requires the patient to have residual salivary gland function. Unfortunately, it is well established that in most cases radiotherapy destroys most of the salivary gland and associated salivary secretions.     

  20. Measurement of inclusive antiprotons from Au+Au collisions at square root of s(NN) = 130 GeV.

    Science.gov (United States)

    Adler, C; Ahammed, Z; Allgower, C; Amonett, J; Anderson, B D; Anderson, M; Averichev, G S; Balewski, J; Barannikova, O; Barnby, L S; Baudot, J; Bekele, S; Belaga, V V; Bellwied, R; Berger, J; Bichsel, H; Bland, L C; Blyth, C O; Bonner, B E; Boucham, A; Brandin, A; Cadman, R V; Caines, H; Calderón de la Barca Sánchez, M; Cardenas, A; Carroll, J; Castillo, J; Castro, M; Cebra, D; Chattopadhyay, S; Chen, M L; Chen, Y; Chernenko, S P; Cherney, M; Chikanian, A; Choi, B; Christie, W; Coffin, J P; Cormier, T M; Cramer, J G; Crawford, H J; DeMello, M; Deng, W S; Derevschikov, A A; Didenko, L; Draper, J E; Dunin, V B; Dunlop, J C; Eckardt, V; Efimov, L G; Emelianov, V; Engelage, J; Eppley, G; Erazmus, B; Fachini, P; Faine, V; Filimonov, K; Finch, E; Fisyak, Y; Flierl, D; Foley, K J; Fu, J; Gagliardi, C A; Gagunashvili, N; Gans, J; Gaudichet, L; Germain, M; Geurts, F; Ghazikhanian, V; Grabski, J; Grachov, O; Grigoriev, V; Guedon, M; Gushin, E; Hallman, T J; Hardtke, D; Harris, J W; Heffner, M; Heppelmann, S; Herston, T; Hippolyte, B; Hirsch, A; Hjort, E; Hoffmann, G W; Horsley, M; Huang, H Z; Humanic, T J; Hümmler, H; Igo, G; Ishihara, A; Ivanshin, Y I; Jacobs, P; Jacobs, W W; Janik, M; Johnson, I; Jones, P G; Judd, E; Kaneta, M; Kaplan, M; Keane, D; Kisiel, A; Klay, J; Klein, S R; Klyachko, A; Konstantinov, A S; Kotchenda, L; Kovalenko, A D; Kramer, M; Kravtsov, P; Krueger, K; Kuhn, C; Kulikov, A I; Kunde, G J; Kunz, C L; Kutuev, R K; Kuznetsov, A A; Lakehal-Ayat, L; Lamas-Valverde, J; Lamont, M A; Landgraf, J M; Lange, S; Lansdell, C P; Lasiuk, B; Laue, F; Lebedev, A; Lednický, R; Leontiev, V M; LeVine, M J; Li, Q; Lindenbaum, S J; Lisa, M A; Liu, F; Liu, L; Liu, Z; Liu, Q J; Ljubicic, T; Llope, W J; LoCurto, G; Long, H; Longacre, R S; Lopez-Noriega, M; Love, W A; Lynn, D; Majka, R; Margetis, S; Martin, L; Marx, J; Matis, H S; Matulenko, Y A; McShane, T S; Meissner, F; Melnick, Y; Meschanin, A; Messer, M; Miller, M L; Milosevich, Z; Minaev, N G; Mitchell, J; Moiseenko, V A; Moore, C F; Morozov, V; de Moura, M M; Munhoz, M G; Mutchler, G S; Nelson, J M; Nevski, P; Nikitin, V A; Nogach, L V; Norman, B; Nurushev, S B; Odyniec, G; Ogawa, A; Okorokov, V; Oldenburg, M; Olson, D; Paic, G; Pandey, S U; Panebratsev, Y; Panitkin, S Y; Pavlinov, A I; Pawlak, T; Perevoztchikov, V; Peryt, W; Petrov, V A; Platner, E; Pluta, J; Porile, N; Porter, J; Poskanzer, A M; Potrebenikova, E; Prindle, D; Pruneau, C; Radomski, S; Rai, G; Ravel, O; Ray, R L; Razin, S V; Reichhold, D; Reid, J G; Retiere, F; Ridiger, A; Ritter, H G; Roberts, J B; Rogachevski, O V; Romero, J L; Roy, C; Rykov, V; Sakrejda, I; Sandweiss, J; Saulys, A C; Savin, I; Schambach, J; Scharenberg, R P; Schmitz, N; Schroeder, L S; Schüttauf, A; Schweda, K; Seger, J; Seliverstov, D; Seyboth, P; Shahaliev, E; Shestermanov, K E; Shimanskii, S S; Shvetcov, V S; Skoro, G; Smirnov, N; Snellings, R; Sowinski, J; Spinka, H M; Srivastava, B; Stephenson, E J; Stock, R; Stolpovsky, A; Strikhanov, M; Stringfellow, B; Struck, C; Suaide, A A; Sugarbaker, E; Suire, C; Sumbera, M; Symons, T J; de Toledo, A S; Szarwas, P; Takahashi, J; Tang, A H; Thomas, J H; Thompson, M; Tikhomirov, V; Trainor, T A; Trentalange, S; Tribble, R E; Tokarev, M; Tonjes, M B; Trofimov, V; Tsai, O; Turner, K; Ullrich, T; Underwood, D G; Van Buren, G; VanderMolen, A M; Vanyashin, A; Vasilevski, I M; Vasiliev, A N; Vigdor, S E; Voloshin, S A; Wang, F; Ward, H; Watson, J W; Wells, R; Wenaus, T; Westfall, G D; Whitten, C; Wieman, H; Willson, R; Wissink, S W; Witt, R; Xu, N; Xu, Z; Yakutin, A E; Yamamoto, E; Yang, J; Yepes, P; Yurevich, V I; Zanevski, Y V; Zborovský, I; Zhang, H; Zhang, W M; Zoulkarneev, R; Zubarev, A N

    2001-12-24

    We report the first measurement of inclusive antiproton production at midrapidity in Au+Au collisions at square root of s(NN) = 130 GeV by the STAR experiment at RHIC. The antiproton transverse mass distributions in the measured transverse momentum range of 0.25antiproton rapidity density is found to scale approximately with the negative hadron multiplicity density.

  1. Measurement of the stopping power of silicon for antiprotons between 0. 2 and 3 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Medenwaldt, R.; Moeller, S.P.; Uggerhoej, E.; Worm, T. (Inst. for Synchrotron Radiation, Aarhus Univ. (Denmark)); Hvelplund, P.; Knudsen, H. (Inst. of Physics, Aarhus Univ. (Denmark)); Elsener, K. (CERN, Geneva (Switzerland)); Morenzoni, E. (Paul Scherrer Inst., Villigen (Switzerland))

    1991-05-01

    Our previous measurement of the stopping power of silicon power of silicon for antiprotons has been extended down to 200 keV. The antiproton stopping power is found to be more than 30% lower than that for equivelocity protons at 200 keV. The ''Z{sub 1}{sup 3} contribution'' to the stopping power (the Barkas effect) is deduced by comparing the stopping power for protons and antiprotons. Comparisons to theoretical estimates are made. (orig.).

  2. Measurement of the stopping power of silicon for antiprotons between 0.2 and 3 MeV

    Science.gov (United States)

    Medenwaldt, R.; Møller, S. P.; Uggerhøj, E.; Worm, T.; Hvelplund, P.; Knudsen, H.; Elsener, K.; Morenzoni, E.

    1991-05-01

    Our previous measurement of the stopping power of silicon for antiprotons has been extended down to 200 keV. The antiproton stopping power is found to be more than 30% lower than that for equivelocity protons at 200 keV. The " Z13 contribution" to the stopping power (the Barkas effect) is deduced by comparing the stopping power for protons and antiprotons. Comparisons to theoretical estimates are made.

  3. Measurement of the Z31 contribution to the stopping power using MeV protons and antiprotons: The Barkas effect

    Science.gov (United States)

    Andersen, L. H.; Hvelplund, P.; Knudsen, H.; Möller, S. P.; Pedersen, J. O. P.; Uggerhöj, E.; Elsener, K.; Morenzoni, E.

    1989-04-01

    The stopping power for antiprotons has been measured for the first time. The antiproton stopping power of silicon is found to be 3%-19% lower than for equivelocity protons over the energy range 3.01 to 0.538 MeV. The ``Z31 contribution'' to the stopping power (the Barkas effect) is deduced by comparing the stopping power for protons and antiprotons.

  4. Erythropoietin and radiotherapy; Erythropoietine et radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Le Fur, E.; Albarghach, M.N.; Pradier, O. [CHU de Morvan, Dept. de radiotherapie, 29 - Brest (France)

    2010-01-15

    Erythropoietin (E.P.O.) is a glycoprotein hormone. This hormone is a growth factor for red blood cells precursors in the bone marrow. The decrease of oxygen partial pressure, a reduced number of erythrocytes caused by bleeding or excessive destruction, or increased tissues oxygen requirements lead to increased secretion of E.P.O.. Its action takes place on bone marrow erythroblastic cells through specific receptors. E.P.O. stimulates the proliferation of red cell precursors stem cells in the bone marrow, thus increasing their production in one to two weeks. The effectiveness of E.P.O. at increasing haemoglobin and improving patients quality of life has been demonstrated by several studies. However, its use in radiotherapy remains controversial. While tumour hypoxia caused by anaemia is a factor of radio resistance and thus a source of local failure, tumour expression of E.P.O. receptors presents a significant risk for tumour progression and neo-angiogenesis, which would be increased during the administration of E.P.O.. The purpose of this article is to answer the question: is there a place for E.P.O. in combination with radiotherapy in the management of cancer?

  5. Radiotherapy for craniopharyngioma.

    Science.gov (United States)

    Aggarwal, Ajay; Fersht, Naomi; Brada, Michael

    2013-03-01

    Radiotherapy remains the mainstay of multidisciplinary management of patients with incompletely resected and recurrent craniopharyngioma. Advances in imaging and radiotherapy technology offer new alternatives with the principal aim of improving the accuracy of treatment and reducing the volume of normal brain receiving significant radiation doses. We review the available technologies, their technical advantages and disadvantages and the published clinical results. Fractionated high precision conformal radiotherapy with image guidance remains the gold standard; the results of single fraction treatment are disappointing and hypofractionation should be used with caution as long term results are not available. There is insufficient data on the use of protons to assess the comparative efficacy and toxicity. The precision of treatment delivery needs to be coupled with experienced infrastructure and more intensive quality assurance to ensure best treatment outcome and this should be carried out within multidisciplinary teams experienced in the management of craniopharyngioma. The advantages of the combined skills and expertise of the team members may outweigh the largely undefined clinical gain from novel radiotherapy technologies.

  6. [Radiotherapy for Graves' ophthalmopathy].

    Science.gov (United States)

    Kuhnt, T; Müller, A C; Janich, M; Gerlach, R; Hädecke, J; Duncker, G I W; Dunst, J

    2004-11-01

    Graves' ophthalmopathy (GO) is the most frequent extrathyroidal manifestation of Graves' disease, an autoimmune disorder of the thyroid, whereas the precise pathogenesis still remains unclear. In Hashimoto's thyroiditis the occurrence of proptosis is an extremely rare event. The therapy for middle and severe courses of GO shows in partly disappointing results, although several therapy modalities are possible (glucocorticoid therapy, radiotherapy, antithyroid drug treatment, surgery). All these therapies lead in only 40 - 70 % to an improvement of the pathogenic symptoms. An intensive interdisciplinary cooperation is necessary to satisfy the requirements for the treatment of Graves' ophthalmopathy. As a consequence of the very different results of the few of clinical studies that were accomplished with reference to this topic, treatment by radiotherapy in the management of the disease is presently controversially discussed. In the German-speaking countries the radiotherapy is, however, firmly established as a therapy option in the treatment of the moderate disease classes (class 2-5 according to NO SPECS), especially if diplopia is present. This article describes the sequences, dosages and fractionation schemes as well as the risks and side effects of the radiotherapy. Altogether, radiotherapy is assessed as an effective and sure method. The administration of glucocorticoids can take place before the beginning of or during the radiotherapy. For the success of treatment the correct selection of patients who may possibly profit from a radiotherapy is absolutely essential. By realising that GO proceeds normally over a period of 2-5 years, which is followed by a period of fibrotic alteration, the application of the radiotherapy in the early, active phase is indispensable. A precise explanation for the effects of radiotherapy in treatment of the GO does not exist at present. The determination of the most effective irradiation doses was made from retrospectively evaluated

  7. Antiproton Flux in Cosmic Ray Propagation Models with Anisotropic Diffusion

    CERN Document Server

    Grajek, Phillip

    2010-01-01

    Recently a cosmic ray propagation model has been introduced, where anisotropic diffusion is used as a mechanism to allow for $\\mathcal{O}(100)$ km/s galactic winds. This model predicts a reduced antiproton background flux, suggesting an excess is being observed. We implement this model in GALPROP v50.1 and perform a $\\chi^2$ analysis for B/C, $^{10}$Be/$^{9}$Be, and the recent PAMELA $\\bar{p}/p$ datasets. By introducing a power-index parameter $\\alpha$ that dictates the dependence of the diffusion coefficient $D_{xx}$ on height $|z|$ away from the galactic plane, we confirm that isotropic diffusion models with $\\alpha=0$ cannot accommodate high velocity convective winds suggested by ROSAT, while models with $\\alpha=1$ ($D_{xx}\\propto |z|$) can give a very good fit. A fit to B/C and $^{10}$Be/$^{9}$Be data predicts a lower $\\bar{p}/p$ flux ratio than the PAMELA measurement at energies between approximately 2 GeV to 20 GeV. A combined fit including in addition the $\\bar{p}/p$ data is marginal, suggesting only a...

  8. Cooling of ions and antiprotons with magnetized electrons

    CERN Document Server

    Mollers, B; Walter, M; Zwicknagel, G; Carli, Christian; Nersisyan, H

    2004-01-01

    Electron cooling is a well-established method to improve the phase space quality of ion beams in storage rings. More recently antiprotons have been cooled in traps, first by electrons and then by positrons in order to produce antihydrogen atoms as simplest form of antimatter for CPT-tests. During these cooling processes the light particles are guided by strong external magnetic fields which imposes a challenge to the theoretical description. Within the binary collision model we treat the Coulomb interaction as second-order perturbation to the helix motion of the light particles and also by numerical simulations. In the complementary dielectric theory we calculate the polarization of the light particles by solving the nonlinear Vlasov-Poisson equation as well as linear response. It turns out that the linearization becomes dubious at low ion velocities. In the presence of a strong magnetic field the numerically expensive solution of the Vlasov-Poisson equation is the method of choice, alternatively one may empl...

  9. Constraining pre big-bang-nucleosynthesis expansion using cosmic antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Schelke, M. [Istituto Nazionale di Fisica Nucleare, Torino (Italy); Catena, R. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Fornengo, N. [Torino Univ. (Italy). Dipt. di Fisica Teorica]|[Istituto Nazionale di Fisica Nucleare, Torino (Italy); Masiero, A. [Pavoa Univ. (Italy). Dipt. di Fisica]|[Istituto Nazionale di Fisica Nucleare, Padova (Italy); Pietroni, M. [Istituto Nazionale di Fisica Nucleare, Padova (Italy)

    2006-06-15

    A host of dark energy models and non-standard cosmologies predict an enhanced Hubble rate in the early Universe: perfectly viable models, which satisfy Big Bang Nucleosynthesis (BBN), cosmic microwave background and general relativity tests, may nevertheless lead to enhancements of the Hubble rate up to many orders of magnitude. In this paper we show that strong bounds on the pre-BBN evolution of the Universe may be derived, under the assumption that dark matter is a thermal relic, by combining the dark matter relic density bound with constraints coming from the production of cosmic-ray antiprotons by dark matter annihilation in the Galaxy. The limits we derive can be sizable and apply to the Hubble rate around the temperature of dark matter decoupling. For dark matter masses lighter than 100 GeV, the bound on the Hubble-rate enhancement ranges from a factor of a few to a factor of 30, depending on the actual cosmological model, while for a mass of 500 GeV the bound falls in the range 50-500. Uncertainties in the derivation of the bounds and situations where the bounds become looser are discussed. We finally discuss how these limits apply to some specific realizations of non-standard cosmologies: a scalar-tensor gravity model, kination models and a Randall-Sundrum D-brane model. (Orig.)

  10. Elastic scattering, polarization and absorption of relativistic antiprotons on nuclei

    CERN Document Server

    Larionov, A B

    2016-01-01

    We perform Glauber model calculations of the antiproton-nucleus elastic and quasielastic scattering and absorption in the beam momentum range $\\sim 0.5\\div10$ GeV/c. A good agreement of our calculations with available LEAR data and with earlier Glauber model studies of the $\\bar p A$ elastic scattering allows us to make predictions at the beam momenta of $\\sim 10$ GeV/c, i.e at the regime of the PANDA experiment at FAIR. The comparison with the proton-nucleus elastic scattering cross sections shows that the diffractive minima are much deeper in the $\\bar p A$ case due to smaller absolute value of the ratio of the real-to-imaginary part of the elementary elastic amplitude. Significant polarization signal for $\\bar p A$ elastic scattering at 10 GeV/c is expected. We have also revealed a strong dependence of the $\\bar p A$ absorption cross section on the slope parameter of the transverse momentum dependence of the elementary $\\bar pN$ amplitude. The $\\bar p A$ optical potential is discussed.

  11. Elastic scattering, polarization and absorption of relativistic antiprotons on nuclei

    Science.gov (United States)

    Larionov, A. B.; Lenske, H.

    2017-01-01

    We perform Glauber model calculations of the antiproton-nucleus elastic and quasielastic scattering and absorption in the beam momentum range ∼ 0.5 ÷ 10 GeV / c. A good agreement of our calculations with available LEAR data and with earlier Glauber model studies of the p bar A elastic scattering allows us to make predictions at the beam momenta of ∼10 GeV/c, i.e. at the regime of the PANDA experiment at FAIR. The comparison with the proton-nucleus elastic scattering cross sections shows that the diffractive minima are much deeper in the p bar A case due to smaller absolute value of the ratio of the real-to-imaginary part of the elementary elastic amplitude. Significant polarization signal for p bar A elastic scattering at 10 GeV/c is expected. We have also revealed a strong dependence of the p bar A absorption cross section on the slope parameter of the transverse momentum dependence of the elementary p bar N amplitude. The p bar A optical potential is discussed.

  12. Density functional theory investigation of antiproton-helium collisions

    CERN Document Server

    Henkel, N; Lüdde, H J; Kirchner, T; 10.1103/PhysRevA.80.032704

    2011-01-01

    We revisit recent developments in the theoretical foundations of time-dependent density functional theory (TDDFT). TDDFT is then applied to the calculation of total cross sections for ionization processes in the antiproton-Helium collision system. The Kohn-Sham potential is approximated as the sum of the Hartree-exchange potential and a correlation potential that was proposed in the context of laser-induced ionization. Furthermore, some approaches to the problem of calculating the ionization probabilities from the density are discussed. Small projectile energies below 5keV are considered as well as those in the range from 5 to 1000 keV. Results are compared with former calculations and with experimental data. We find that the correlation potential yields no obvious improvement of the results over the exchange-only approximation where the correlation potential is neglected. Furthermore, we find the problem of calculating the desired observables crucial, introducing errors of at least the same order of magnitud...

  13. Time purified/separated antiproton beam at the AGS

    Energy Technology Data Exchange (ETDEWEB)

    Bachman, M.; Barlett, M.L.; Bonner, B.; Borenstein, S.; Bridges, D.; Brown, H.; Buchanan, J.; Clement, J.C.; Daftari, I.; Debbe, R.

    1984-11-15

    A 1 km antiproton beam has been designed for construction at the AGS. The momentum band can be varied between +- 0.3% to +- 1.0%, and the resolution for tagged particles will be deltap/papprox.10/sup -4/ at beam rates as high as 10/sup 6/ p-bar/s. Separation by decay purification will be on the order of 1 p-bar/10(..pi../sup -/+..mu../sup -/). This beam will be used in a detailed investigation of Charmonium including a measurement of the chi widths. We will also search for expected but as yet unseen states, and search for possible I = 1 events which would imply the existence of four quark states. This facility will also lend itself to a wide variety of exciting physics such as the proton form factor including both e/sup +/e/sup -/ and ..gamma gamma.. final states, two-body hadron final states, antinucleus yields, and possibly tagged hadron beams (i.e., ..lambda.., ..gamma.., etc.). When heavy ions become available at the AGS, one can measure various long lived particle yields. Finally, with as many as 10/sup 7/ polarized muons in the beam, one has the possibility to use them for nuclear structure studies.

  14. Time purified/separated antiproton beam at the AGS

    Energy Technology Data Exchange (ETDEWEB)

    Bachman, M.; Barlett, M.L.; Bonner, B.; Borenstein, S.; Bridges, D.; Brown, H.; Buchanan, J.; Clement, J.C.; Daftari, I.; Debbe, R.

    1984-01-01

    A 1 km antiproton beam has been designed for construction at the AGS. The momentum band can be varied between +-0.3% to +-1.0%, and the resolution for tagged particles will be deltap/p approx. 10/sup -4/ at beam rates as high as 10/sup 6/ anti p/s. Separation by decay purification will be on the order of 1 anti p/10(..pi../sup -/+..mu../sup -/). This beam will be used in a detailed investigation of Charmonium including a measurement of the chi widths. We will also search for expected but as yet unseen states, and search for possible I=1 events which would imply the existence of four quark states. This facility will also lend itself to a wide variety of exciting physics such as the proton form factor including both e/sup +/e/sup -/ and ..gamma gamma.. final states, two-body hadron final states, anti-nucleus yields, and possibly tagged hadron beams (i.e., Lambda, E, etc.). When heavy ions become available at the AGS, one can measure various long lived particle yields. Finally, with as many as 10/sup 7/ polarized muons in the beam, one has the possibility to use them for nuclear structure studies.

  15. Radiotherapy of cutaneous lymphomas; Radiotherapie des lymphomes cutanes

    Energy Technology Data Exchange (ETDEWEB)

    Kirova, Y.M.; Piedbois, Y.; Pan, Q.; Guo, J.P.; Le Bourgeois, J.P. [Hopital Henri-Mondor, 94 - Creteil (France). Dept. de cancerologie

    1999-03-01

    Radiotherapy plays an important role in the treatment of cutaneous lymphomas. In the treatment of Mycosis fungoides, total skin electron beam radiation therapy is efficient for patients with limited and superficial forms of the disease. Radiotherapy is also efficient for the locally advanced forms of non-epidermo-tropic lymphomas. The palliative radiotherapy is indicated for advanced, nodular and treatment resistant forms of cutaneous lymphomas and for voluminous lymphadenopathies. (authors)

  16. Multiple ionization of He, Ne, and Ar by fast protons and antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, L.H.; Hvelplund, P.; Knudsen, H.; Moller, S.P.; Sorensen, A.H.; Elsener, K.; Rensfelt, K.; Uggerhoj, E.

    1987-10-15

    Single and multiple ionization of He, Ne, and Ar has been studied experimentally by impact of fast protons and antiprotons. The single-ionization cross sections obtained with protons and antiprotons are found to be the same. The double-ionization cross sections obtained with antiprotons, however, are much larger than those obtained with protons at equal velocity. This difference is found for all three gases but the effect is largest for He and Ne, where the difference is about a factor of 2 at 1 MeV/amu. The difference is discussed in terms of interference between two collision mechanisms which both result in double-electron escape. Experimental information on the magnitude of the interference term is obtained by inclusion of double-ionization data, partly obtained in this work, for fast electron and ..cap alpha..-particle impact. For triple ionization of Ne, we also find that antiprotons yield much larger cross sections than protons do. Identical cross sections, however, are found for triple ionization of Ar with protons and antiprotons. This is believed to be due to the fact that triple ionization of Ar is mainly a consequence of a single vacancy produced in an inner shell followed by electronic rearrangement. This observation supports the interpretation that the observed charge effect is due to an interference effect in the outermost shell.

  17. Evidence for the Stochastic Acceleration of Secondary Antiprotons by Supernova Remnants

    Energy Technology Data Exchange (ETDEWEB)

    Cholis, Ilias [Johns Hopkins U.; Hooper, Dan [Chicago U., KICP; Linden, Tim [Ohio State U.

    2017-01-16

    The antiproton-to-proton ratio in the cosmic-ray spectrum is a sensitive probe of new physics. Using recent measurements of the cosmic-ray antiproton and proton fluxes in the energy range of 1-1000 GeV, we study the contribution to the $\\bar{p}/p$ ratio from secondary antiprotons that are produced and subsequently accelerated within individual supernova remnants. We consider several well-motivated models for cosmic-ray propagation in the interstellar medium and marginalize our results over the uncertainties related to the antiproton production cross section and the time-, charge-, and energy-dependent effects of solar modulation. We find that the increase in the $\\bar{p}/p$ ratio observed at rigidities above $\\sim$ 100 GV cannot be accounted for within the context of conventional cosmic-ray propagation models, but is consistent with scenarios in which cosmic-ray antiprotons are produced and subsequently accelerated by shocks within a given supernova remnant. In light of this, the acceleration of secondary cosmic rays in supernova remnants is predicted to substantially contribute to the cosmic-ray positron spectrum, accounting for a significant fraction of the observed positron excess.

  18. Modeling of the Near-Earth Low-Energy Antiproton Fluxes

    Directory of Open Access Journals (Sweden)

    U. B. Jayanthi

    2011-01-01

    Full Text Available The local interstellar antiproton spectrum is simulated taking into account antineutron decay, (He,p interaction, secondary and tertiary antiproton production, and the solar modulation in the “force field” approximation. Inclusive invariant cross-sections were obtained through a Monte Carlo procedure using the Multistage Dynamical Model code simulating various processes of the particle production. The results of the simulations provided flux values of 4⋅10−3 to 10−2 and 10−2 to 1.7⋅10−2 antiprotons/(2 s sr GeV at energies of 0.2 and 1 GeV, respectively, for the solar maximum and minimum epochs. Simulated flux of the trapped antiprotons in the inner magnetosphere due to galactic cosmic ray (GCR interactions with the atmospheric constituents exceeds the galactic antiproton flux up to several orders. These simulation results considering the assumptions with the attendant limitations are in comprehensive agreement with the experimental data including the PAMELA ones.

  19. New calculation of antiproton production by cosmic ray protons and nuclei

    CERN Document Server

    Kachelriess, Michael; Ostapchenko, Sergey S

    2015-01-01

    A dramatic increase in the accuracy and statistics of space-borne cosmic ray (CR) measurements has yielded several breakthroughs over the last several years. The most puzzling is the rise in the positron fraction above ~10 GeV over the predictions of the propagation models assuming pure secondary production. The accuracy of the antiproton production cross section is critical for astrophysical applications and searches for new physics since antiprotons in CRs seem to hold the keys to many puzzles including the origin of those excess positrons. However, model calculations of antiproton production in CR interactions with interstellar gas are often employing parameterizations that are out of date or are using outdated physical concepts. That may lead to an incorrect interpretation of antiproton data which could have broad consequences for other areas of astrophysics. In this work, we calculate antiproton production in pp-, pA-, and AA-interactions using EPOS-LHC and QGSJET-II-04, two of the most advanced Monte Ca...

  20. Direct detection of antiprotons with the Timepix3 in a new electrostatic selection beamline

    Science.gov (United States)

    Pacifico, N.; Aghion, S.; Alozy, J.; Amsler, C.; Ariga, A.; Ariga, T.; Bonomi, G.; Bräunig, P.; Bremer, J.; Brusa, R. S.; Cabaret, L.; Caccia, M.; Campbell, M.; Caravita, R.; Castelli, F.; Cerchiari, G.; Chlouba, K.; Cialdi, S.; Comparat, D.; Consolati, G.; Demetrio, A.; Di Noto, L.; Doser, M.; Dudarev, A.; Ereditato, A.; Evans, C.; Ferragut, R.; Fesel, J.; Fontana, A.; Gerber, S.; Giammarchi, M.; Gligorova, A.; Guatieri, F.; Haider, S.; Holmestad, H.; Huse, T.; Jordan, E.; Kellerbauer, A.; Kimura, M.; Krasnický, D.; Lagomarsino, V.; Lansonneur, P.; Lawler, G.; Lebrun, P.; Llopart, X.; Malbrunot, C.; Mariazzi, S.; Marx, L.; Matveev, V.; Mazzotta, Z.; Nebbia, G.; Nedelec, P.; Oberthaler, M.; Pagano, D.; Penasa, L.; Petracek, V.; Pistillo, C.; Prelz, F.; Prevedelli, M.; Ravelli, L.; Resch, L.; Røhne, O. M.; Rotondi, A.; Sacerdoti, M.; Sandaker, H.; Santoro, R.; Scampoli, P.; Smestad, L.; Sorrentino, F.; Spacek, M.; Storey, J.; Strojek, I. M.; Testera, G.; Tietje, I.; Tlustos, L.; Widmann, E.; Yzombard, P.; Zavatarelli, S.; Zmeskal, J.; Zurlo, N.

    2016-09-01

    We present here the first results obtained employing the Timepix3 for the detection and tagging of annihilations of low energy antiprotons. The Timepix3 is a recently developed hybrid pixel detector with advanced Time-of-Arrival and Time-over-Threshold capabilities and has the potential of allowing precise kinetic energy measurements of low energy charged particles from their time of flight. The tagging of the characteristic antiproton annihilation signature, already studied by our group, is enabled by the high spatial and energy resolution of this detector. In this study we have used a new, dedicated, energy selection beamline (GRACE). The line is symbiotic to the AEgIS experiment at the CERN Antiproton Decelerator and is dedicated to detector tests and possibly antiproton physics experiments. We show how the high resolution of the Timepix3 on the Time-of-Arrival and Time-over-Threshold information allows for a precise 3D reconstruction of the annihilation prongs. The presented results point at the potential use of the Timepix3 in antimatter-research experiments where a precise and unambiguous tagging of antiproton annihilations is required.

  1. Direct detection of antiprotons with the Timepix3 in a new electrostatic selection beamline

    Energy Technology Data Exchange (ETDEWEB)

    Pacifico, N., E-mail: nicola.pacifico@cern.ch [Institute of Physics and Technology, University of Bergen, Allgaten 55, 5007 Bergen (Norway); Aghion, S. [Politecnico of Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); INFN Milano, via Celoria 16, 20133 Milano (Italy); Alozy, J. [Physics Department, CERN, 1211 Geneva 23 (Switzerland); Amsler, C.; Ariga, A.; Ariga, T. [Laboratory for High Energy Physics, Albert Einstein Center for Fundamental Physics, University of Bern, 3012 Bern (Switzerland); Bonomi, G. [Department of Mechanical and Industrial Engineering, University of Brescia, via Branze 38, 25123 Brescia (Italy); INFN Pavia, via Bassi 6, 27100 Pavia (Italy); Bräunig, P. [Kirchhoff-Institute for Physics, Heidelberg University, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [Physics Department, CERN, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Department of Physics, University of Trento, via Sommarive 14, 38123 Povo, Trento (Italy); TIFPA/INFN Trento, via Sommarive 14, 38123 Povo, Trento (Italy); Cabaret, L. [Laboratory Aimé Cotton, University of Paris-Sud, ENS Cachan, CNRS, University Paris-Saclay, 91405 Orsay Cedex (France); Caccia, M. [INFN Milano, via Celoria 16, 20133 Milano (Italy); Department of Science, University of Insubria, Via Valleggio 11, 22100 Como (Italy); Campbell, M. [Physics Department, CERN, 1211 Geneva 23 (Switzerland); Caravita, R. [Department of Physics, University of Genova, via Dodecaneso 33, 16146 Genova (Italy); INFN Genova, via Dodecaneso 33, 16146 Genova (Italy); Castelli, F. [INFN Milano, via Celoria 16, 20133 Milano (Italy); Department of Physics, University of Milano, via Celoria 16, 20133 Milano (Italy); Cerchiari, G. [Max Planck Institute for Nuclear Physics, Saupfercheckweg 1, 69117 Heidelberg (Germany); Chlouba, K. [Czech Technical University, Prague, Brehov 7, 11519 Prague 1 (Czech Republic); and others

    2016-09-21

    We present here the first results obtained employing the Timepix3 for the detection and tagging of annihilations of low energy antiprotons. The Timepix3 is a recently developed hybrid pixel detector with advanced Time-of-Arrival and Time-over-Threshold capabilities and has the potential of allowing precise kinetic energy measurements of low energy charged particles from their time of flight. The tagging of the characteristic antiproton annihilation signature, already studied by our group, is enabled by the high spatial and energy resolution of this detector. In this study we have used a new, dedicated, energy selection beamline (GRACE). The line is symbiotic to the AEgIS experiment at the CERN Antiproton Decelerator and is dedicated to detector tests and possibly antiproton physics experiments. We show how the high resolution of the Timepix3 on the Time-of-Arrival and Time-over-Threshold information allows for a precise 3D reconstruction of the annihilation prongs. The presented results point at the potential use of the Timepix3 in antimatter-research experiments where a precise and unambiguous tagging of antiproton annihilations is required.

  2. Melanoma: Last call for radiotherapy.

    Science.gov (United States)

    Espenel, Sophie; Vallard, Alexis; Rancoule, Chloé; Garcia, Max-Adrien; Guy, Jean-Baptiste; Chargari, Cyrus; Deutsch, Eric; Magné, Nicolas

    2017-02-01

    Melanoma is traditionally considered to be a radioresistant tumor. However, radiotherapy and immunotherapy latest developments might upset this radiobiological dogma. Stereotactic radiotherapy allows high dose per fraction delivery, with high dose rate. More DNA lethal damages, less sublethal damages reparation, endothelial cell apoptosis, and finally clonogenic cell dysfunction are produced, resulting in improved local control. Radiotherapy can also enhance immune responses, inducing neoantigens formation, tumor antigen presentation, and cytokines release. A synergic effect of radiotherapy with immunotherapy is expected, and might lead to abscopal effects. If hadrontherapy biological properties seem able to suppress hypoxia-induced radioresistance and increase biological efficacy, ballistic advantages over photon radiations might also improve radiotherapy outcomes on usually poor prognosis locations. The present review addresses biological and clinical effects of high fraction dose, bystander effect, abscopal effect, and hadrontherapy features in melanoma. Clinical trials results are warranted to establish indications of innovative radiotherapy in melanoma.

  3. Antiproton–to–electron mass ratio determined by two-photon laser spectroscopy of antiprotonic helium atoms

    Directory of Open Access Journals (Sweden)

    Sótér A.

    2014-03-01

    Full Text Available The ASACUSA collaboration of CERN has recently carried out two-photon laser spectroscopy of antiprotonic helium atoms. Three transition frequencies were determined with fractional precisions of 2.3–5 parts in 109. By comparing the results with three-body QED calculations, the antiproton-to-electron mass ratio was determined as 1836.1526736(23.

  4. Energy-dependent partial-wave analysis of all antiproton-proton scattering data below 925 MeV/c

    NARCIS (Netherlands)

    Zhou, Daren; Timmermans, Rob G. E.

    2012-01-01

    Background: There is a renewed experimental interest in antiproton-proton scattering with an intense, possibly polarized antiproton beam. On the theoretical side, significant progress has been made in the understanding of the nuclear force from chiral effective field theory. Purpose: We provide a hi

  5. A silicon multiplicity detector system for an experiment on the interaction of antiprotons with nuclei at BNL

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, S.; Bonner, B.E.; Buchanan, J.A.; Clement, J.M.; Empl, A.; Mutchler, G.S.; Toshkov, S. (Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.); Eiseman, S.E.; Etkin, A.; Foley, K.J.; Hackenburg, R.W.; Longacre, R.S.; Love, W.A.; Morris, T.W.; Platner, E.D.; Saulys, A.C. (Brookhaven National Lab., Upton, NY (United States)); Chan, C.S.; Kramer, M.A.; Lindenbaum, S.J. (City Coll., New York, NY (Unit

    1991-01-01

    A Large Angle Multiplicity Detector (LAMD) system has been developed and used at the BNL experiment E854: Antiproton Nucleus Interactions. This system performed well with an energetic antiproton beam. Charged particle multiplicity distributions from pbar annihilations were measured. We discuss the design and performance of the LAMD system in this paper. 6 refs., 10 figs.

  6. A silicon multiplicity detector system for an experiment on the interaction of antiprotons with nuclei at BNL

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, S.; Bonner, B.E.; Buchanan, J.A.; Clement, J.M.; Empl, A.; Mutchler, G.S.; Toshkov, S. [Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.; Eiseman, S.E.; Etkin, A.; Foley, K.J.; Hackenburg, R.W.; Longacre, R.S.; Love, W.A.; Morris, T.W.; Platner, E.D.; Saulys, A.C. [Brookhaven National Lab., Upton, NY (United States); Chan, C.S.; Kramer, M.A.; Lindenbaum, S.J. [City Coll., New York, NY (United States); Hallman, T.J.; Madansky, L. [Johns Hopkins Univ., Baltimore, MD (United States); Peaslee, D.C. [Maryland Univ., College Park, MD (United States)

    1991-12-31

    A Large Angle Multiplicity Detector (LAMD) system has been developed and used at the BNL experiment E854: Antiproton Nucleus Interactions. This system performed well with an energetic antiproton beam. Charged particle multiplicity distributions from pbar annihilations were measured. We discuss the design and performance of the LAMD system in this paper. 6 refs., 10 figs.

  7. A silicon multiplicity detector system for an experiment on the interaction of antiprotons with nuclei at BNL

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, S.; Bonner, B.E.; Buchanan, J.A.; Clement, J.M.; Empl, A.; Mutchler, G.S.; Toshkov, S. (Rice Univ., Houston, TX (United States). Bonner Nuclear Labs.); Eiseman, S.E.; Etkin, A.; Foley, K.J. (Brookhaven National Lab., Upton, NY (United States))

    1992-08-01

    A Large Angle Multiplicity Detector (LAMD) system has been developed and used at the BNL experiment E854: Antiproton Nucleus Interactions. This system performed well with an energetic antiproton beam. Charged particle multiplicity distributions from [bar p] annihilations were measured. The authors discuss the design and performance of the LAMD system in this paper.

  8. Radiotherapy of vertebral hemangiomas

    Energy Technology Data Exchange (ETDEWEB)

    Sakata, Kohichi; Hareyama, Masato; Oouchi, Atushi; Sido, Mitsuo; Nagakura, Hisayasu; Tamakawa, Mituharu; Akiba, Hidenari; Morita, Kazuo [Dept. of Radiology, Sapporo Medical Univ., School of Medicine (Japan)

    1997-12-31

    Between 1975 and 1996, 14 patients (11 females, 3 males) with vertebral hemangioma received treatment with radiotherapy. Thirteen patients had a history of back pain or lumbago and 2 patients had neurological symptoms such as sensory impairment or paraplegia. The standard dose administered was 36 Gy in 18 fractions (five treatments per week). In the 13 patients with pain, this was completely or partially relieved. The condition of a man with hypesthesia of the legs deteriorated and a woman with paraplegia who was treated with decompressive laminectomy followed by radiotherapy recovered completely after irradiation. CT scan before irradiation showed thickened trabeculae as small punctate areas of sclerosis in all patients. At MR imaging before irradiation, T2-weighted MR images showed areas of high intensity in all patients and MR images demonstrated lesion enhancement. However, none of the patients who were treated successfully with radiation demonstrated any changes of the affected vertebra in the conventional radiographic films, CT scan or MR imaging, even 5 years after irradiation. Radiological imaging is indispensable for the diagnosis of vertebral hemangiomas but does not appear to be useful for evaluating the effects of radiotherapy. (orig.).

  9. Antiproton production and antideuteron production limits in relativistic heavy ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Dover, C.B. [Brookhaven National Laboratory, Upton, New York 11973 (United States); Huang, H.Z.; Van Buren, G. [University of California at Los Angeles, Los Angeles, California 90095 (United States); Barish, K.N. [University of California at Riverside, Riverside, California 92521 (United States); Fadem, B.; Hill, J.C.; Hoversten, R.; Lajoie, J.G.; Libby, B.; Wohn, F.K. [Iowa State University, Ames, Iowa 50011 (United States); Rabin, M.S. [University of Massachusetts, Amherst, Massachusetts 01003 (United States); Haridas, P.; Pless, I.A. [Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Armstrong, T.A.; Smith, G.A.; Toothacker, W.S. [Pennsylvania State University, University Park, Pennsylvania 16802 (United States); Davies, R.; Hirsch, A.S.; Porile, N.T.; Rimai, A.; Scharenberg, R.P.; Tincknell, M.L. [Purdue University, West Lafayette, Indiana 47907 (United States); Lainis, T. [United States Military Academy, West Point, New York 10996 (United States); Greene, S.V.; Miller, T.E.; Reid, J.D.; Rose, A. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Bennett, S.J.; Cormier, T.M.; Fachini, P.; Li, Q.; Munhoz, M.G.; Pruneau, C.A. [Wayne State University, Detroit, Michigan 48201 (United States); Batsoulli, S.; Chikanian, A.; Coe, S.D.; Finch, L.E.; George, N.K.; Kumar, B.S.; Majka, R.D.; Nagle, J.L.; Pope, J.K.; Rotondo, F.S.; Sandweiss, J.; Slaughter, A.J.; Xu, Z. [Yale University, New Haven, Connecticut 06520 (United States)

    1999-05-01

    We present results from Experiment 864 for antiproton production and antideuteron limits in Au + Pb collisions at 11.5 GeV/c per nucleon. We have measured invariant multiplicities for antiprotons for rapidities 1.4{lt}y{lt}2.4 at low transverse momentum as a function of collision geometry. When compared with the results from Experiment 878 our measurements suggest a significant contribution to the measured antiproton yield from the decay of strange antibaryons. We have also searched for antideuterons and see no statistically significant signal. Thus, we set upper limits on the production at approximately 3{times}10{sup {minus}7} per 10{percent} highest multiplicity Au+Pb interaction. {copyright} {ital 1999} {ital The American Physical Society}

  10. Measurements of Electron Spectra in the Forward Direction in Slow-Antiproton Carbon-Foil Collisions

    Science.gov (United States)

    Yamazaki, Yasunori; Kuroki, Kenro; Komaki, Ken-Ichiro; Andersen, Lars H.; Horsdal-Pedersen, Erik; Hvelplund, Preben; Knudsen, Helge; M{ø}ller, S{ø}ren P.; Uggerh{ø}j, Erik; Elsener, Konrad

    1990-08-01

    The spectrta of electrons emitted in the forward direction from antiproton and proton bombardments on carbon foils have been studied for projectile energies from 500 to 750 keV. Our main observation is that at the electron energy where the well-known convoy peak is observed for proton impact, the spectrum for equivelocity antiprotons is smooth, showing no indication of a deep anticusp. However, around 50 eV below the electron energy where the cusp is observed for proton impact, we have observed a small peak for antiproton impact. The energy and the relative intensity of the bump are found to be consistent with those predicted for electrons released from a wake-riding state.

  11. Study of Anti-Hydrogen and Plasma Physics 4.Observation of Antiproton Beams and Nonneutral Plasmas

    CERN Document Server

    Hori, Masaki; Fujiwara, Makoto; Kuroda, Naofumi

    2004-01-01

    Diagnostics of antiproton beams and nonneutral plasmas are described in this chapter. Parallel plate secondary electron emission detectors are used to non-destructively observe the beam position and intensity without loss. Plastic scintillation tracking detectors are useful in determining the position of annihilations of antiprotons in the trap. Three-dimensional imaging of antiprotons in a Penning trap is discussed. The unique capability of antimatter particle imaging has allowed the observation of the spatial distribution of particle loss in a trap. Radial loss is localized to small spots, strongly breaking the azimuthal symmetry expected for an ideal trap. By observing electrostatic eigen-modes of nonneutral plasmas trapped in the Multi-ring electrode trap, the non-destructive measurement of plasma parameters is performed.

  12. A fussy revisitation of antiprotons as a tool for Dark Matter searches

    CERN Document Server

    Boudaud, Mathieu

    2015-01-01

    Antiprotons are regarded as a powerful probe for Dark Matter (DM) indirect detection and indeed current data from \\PAMELA\\ have been shown to lead to stringent constraints. However, in order to exploit their constraining/discovery power properly, great attention must be put into effects (linked to their propagation in the Galaxy) which may be perceived as subleading but actually prove to be quite relevant. We revisit the computation of the astrophysical background and of the DM antiproton fluxes fully including the effects of: diffusive reacceleration, energy losses including tertiary component and solar modulation (in a force field approximation). Using the updated proton and helium fluxes just released by the \\AMS\\ experiment we reevaluate the secondary astrophysical antiproton to proton ratio and its uncertainties, and compare it with the ratio preliminarly reported by \\AMS. We find no unambiguous evidence for a significant excess with respect to expectations. Yet, some preference for a flatter energy depe...

  13. Parallel plate chambers for monitoring the profiles of high-intensity pulsed antiproton beams

    CERN Document Server

    Hori, Masaki

    2004-01-01

    Two types of beam profile monitor with thin parallel-plate electrodes have been used in experiments carried out at the Low Energy Antiproton Ring (LEAR) and Antiproton Decelerator (AD) of CERN. The detectors were used to measure non-destructively the spatial profiles, absolute intensities, and time structures of 100-300-ns- long beam pulses containing between 10**7 and 10**9 antiprotons. The first of these monitors was a parallel plate ionization chamber operated at gas pressure P=65 mbar. The other was a secondary electron emission detector, and was operated in the ultra-high vacuum of the AD. Both designs may be useful in medical and commercial applications. The position-sensitive electrodes in these detectors were manufactured by a novel method in which a laser trimmer was used to cut strip patterns on metallized polyester foils.

  14. Non-Gaussian beam dynamics in low energy antiproton storage rings

    Science.gov (United States)

    Resta-López, J.; Hunt, J. R.; Welsch, C. P.

    2016-10-01

    In low energy antiproton facilities, where electron cooling is fundamental, the cooling forces together with heating phenomena causing emittance blow-up, such as Intra Beam Scattering (IBS), result in highly non-Gaussian beam distributions. In these cases, a precise simulation of IBS effects is essential to realistically evaluate the long term beam evolution, taking into account the non-Gaussian characteristics of the beam. Here, we analyse the beam dynamics in the Extra Low ENergy Antiproton ring (ELENA), which is a new small synchrotron currently being constructed at CERN to decelerate antiprotons to energies as low as 100 keV. Simulations are performed using the code BETACOOL, comparing different models of IBS.

  15. Classification of high-energy antiprotons on electrons background based on calorimeter data in PAMELA experiment

    Science.gov (United States)

    Dunaeva, O. A.; Alekseev, V. V.; Bogomolov, Yu V.; Lukyanov, A. D.; Malakhov, V. V.; Mayorov, A. G.; Rodenko, S. A.

    2017-01-01

    In modern experimental physics a heterogeneous coordinate-sensitive calorimeters are widely used due to their good characteristics and possibilities to obtain a three-dimensional information of particles interactions. Especially it is important at high-energies when electromagnetic or hadron showers are arise. We propose a quit efficient method to identify antiprotons (positrons) with energies more than 10 GeV on electron (proton) background by calorimeter of such kind. We construct the AdaBoost classifier and SVM to separate particles into two classes, different combinations of energy release along reconstructed particle trajectory were used as feature vector. We test a preliminary version of the method on a calorimeter of the PAMELA magnetic spectrometer. For high-energy particles we got a good quality of classification: it lost about 5 · 10‑2 of antiprotons, and less than 4 · 10‑4 of electrons were classified to antiproton class.

  16. Antiproton signatures from astrophysical and dark matter sources at the galactic center

    CERN Document Server

    Cembranos, J A R; Maroto, A L

    2015-01-01

    The center of our Galaxy is a complex region characterized by extreme phenomena. The presence of the supermassive Sagittarius A* black hole, a high Dark Matter density and an even higher baryonic density are able to produce very energetic processes. Indeed, high energetic gamma rays have been observed by different telescopes, although its origin is not clear. In this work, we constrain the possible antiproton flux component associated to this signal. The expected secondary astrophysical antiproton background already saturates the observed data. It implies that any other important astrophysical source leads to an inconsistent excess, since the theoretical uncertainties corresponding to the mentioned background are small. The constraints depend on the diffusion model and the spectral features of the source. In particular, we consider antiproton spectra described by a power-law, a monochromatic signal and a Standard Model particle-antiparticle channel production.

  17. Measurement of Balmer and Lyman X-rays in antiprotonic hydrogen isotopes at pressures below 300 hPa

    Energy Technology Data Exchange (ETDEWEB)

    Bacher, R.; Bluem, P.; Gotta, D.; Heitlinger, K.; Rohmann, D.; Schneider, M.; Egger, J.; Simons, L.M.; Elsener, K.

    1989-09-01

    X-rays of Balmer and Lyman transitions in antiprotonic hydrogen and of Balmer transitions in antiprotonic deuterium were observed at pressures below 300 hPa using Si(Li) semiconductor detectors. The measurement was performed at the LEAR-facility at a beam momentum of 202 MeV/c. In order to stop antiprotons in a low pressure gaseous target with high efficiency, a novel technique, the cyclotron trap has been used. Absolute yields were determined and compared with cascade calculations. A distinct difference in the cascade of antiprotonic hydrogen and deuterium is found. The parameters of strong interaction in antiprotonic hydrogen are determined to be /epsilon//sub 1s/=-(620+-100) eV, /Gamma//sub 1s/=(1130+-170) eV and /Gamma//sub 2p/=(32+-10) meV. (orig.).

  18. Advanced space propulsion study - antiproton and beamed-power propulsion. Final report, 1 May 1986-30 June 1987

    Energy Technology Data Exchange (ETDEWEB)

    Forward, R.L.

    1987-10-01

    The contract objective was to monitor the research at the forefront of physics and engineering to discover new spacecraft-propulsion concepts. The major topics covered were antiproton-annihilation propulsion, laser thermal propulsion, laser-pushed lightsails, tether transportation systems, solar sails, and metallic hydrogen. Five papers were prepared and are included as appendices. They covered 1) pellet, microwave, and laser-beamed power systems for interstellar transport; 2) a design for a near-relativistic laser-pushed lightsail using near-term laser technology; 3) a survey of laser thermal propulsion, tether transportation systems, antiproton annihilation propulsion, exotic applications of solar sails, and laser-pushed interstellar lightsails; 4) the status of antiproton annihilation propulsion as of 1986, and 5) the prospects for obtaining antimatter ions heavier than antiprotons. Two additional appendices contain the first seven issues of the Mirror Matter Newsletter concerning the science and technology of antimatter, and an annotated bibliography of antiproton science and technology.

  19. Mean dose to lymphocytes during radiotherapy treatments

    Energy Technology Data Exchange (ETDEWEB)

    Brandan, M.E.; Perez-Pastenes, M.A. [Instituto de Fisica (Mexico); Ostrosky-Wegman, P.; Gonsebatt, M.E. [Instituto de Investigaciones Biomedicas (Mexico); Diaz-Perches, R. [Hospital General de Mexico (Mexico)

    1994-10-01

    Using a probabilistic model with parameters from four radiotherapy protocols used in Mexican hospitals for the treatment of cervical cancer, the authors have calculated the distribution of dose to cells in peripheral blood of patients. Values of the mean dose to the lymphocytes during and after a {sup 60}Co treatment are compared to estimates from an in vivo chromosome aberration study performed on five patients. Calculations indicate that the mean dose to the circulating blood is about 2% of the tumor dose, while the mean dose to recirculating lymphocytes may reach up to 7% of the tumor dose. Differences up to a factor of two in the dose to the blood are predicted for different protocols delivering equal tumor doses. The data suggest mean doses higher than the predictions of the model. 10 refs., 3 figs., 2 tabs.

  20. The experiment PANDA: physics with antiprotons at FAIR

    Science.gov (United States)

    Boca, Gianluigi

    2015-05-01

    PANDA is an experiment that will run at the future facility FAIR, Darmstadt, Germany. A high intensity and cooled antiproton beam will collide on a fixed hydrogen or nuclear target covering center-of-mass energies between 2.2 and 5.5 GeV. PANDA addresses various physics aspects from the low energy non-perturbative region towards the perturbative regime of QCD. With the impressive theoretical developments in this field, e.g. lattice QCD, the predictions are becoming more accurate in the course of time. The data harvest with PANDA will, therefore, be an ideal test bench with the aim to provide a deeper understanding of hadronic phenomena such as confinement and the generation of hadron masses. A variety of physics topics will be covered with PANDA, for example: the formation or production of exotic non-qqbar charm meson states connected to the recently observed XYZ spectrum; the study of gluon-rich matter, such as glueballs and hybrids; the spectroscopy of the excited states of strange and charm baryons, their production cross section and their spin correlations; the behaviour of hadrons in nuclear matter; the hypernuclear physics; the electromagnetic proton form factors in the timelike region. The PANDA experiment is designed to achieve the above mentioned physics goals with a setup with the following characteristics: an almost full solid angle acceptance; excellent tracking capabilities with high resolution (1-2 % at 1 GeV/c in the central region); secondary vertex detection with resolution ≈ 100 microns or better; electromagnetic calorimetry for detections of gammas and electrons up to 10 GeV; good particle identification of charge tracks (electrons, muons, pions, kaons, protons); a dedicated interchangeable central apparatus for the hypernuclear physics; detector and data acquisition system capable of working at 20 MHz interaction rate with an intelligent software trigger that can provide maximum flexibility.

  1. First measurement of the antiproton-nucleus annihilation cross section at 125 keV

    Energy Technology Data Exchange (ETDEWEB)

    Aghai-Khozani, H. [Max-Planck-Institut fur Quantenoptik (Germany); Barna, D. [CERN (Switzerland); Corradini, M. [Università degli Studi di Brescia, Dipartimento di Ingegneria dell’Informazione (Italy); Salvador, D. De [Università di Padova, Dipartimento di Fisica e Astronomia (Italy); Hayano, R. [University of Tokyo, Department of Physics (Japan); Hori, M. [Max-Planck-Institut fur Quantenoptik (Germany); Kobayashi, T. [University of Tokyo, Department of Physics (Japan); Leali, M.; Lodi-Rizzini, E.; Mascagna, V. [Università degli Studi di Brescia, Dipartimento di Ingegneria dell’Informazione (Italy); Prest, M. [Università degli Studi dell’Insubria, Dipartimento di Scienza e Alta Tecnologia (Italy); Seiler, D. [TUM Department of Physics E12 (Germany); Soter, A. [Max-Planck-Institut fur Quantenoptik (Germany); Todoroki, K. [University of Tokyo, Department of Physics (Japan); Vallazza, E. [Istituto Nazionale di Fisica Nucleare, Sezione di Trieste (Italy); Venturelli, L., E-mail: venturelli@bs.infn.it [Università degli Studi di Brescia, Dipartimento di Ingegneria dell’Informazione (Italy)

    2015-08-15

    The first observation of in-flight antiproton-nucleus annihilation at ∼130 keV obtained with the ASACUSA detector has demonstrated that the measurement of the cross section of the process is feasible at such extremely low energies Aghai-Khozani, H., et al., Eur. Phys. J. Plus 127, 55 (2012). Here we present the results of the data analysis with the evaluations of the antiproton annihilation cross sections on carbon, palladium and platinum targets at ∼125 keV.

  2. Centrifugal separation and equilibration dynamics in an electron-antiproton plasma

    CERN Document Server

    Andresen, G B; Baquero-Ruiz, Marcelo; Bertsche, William; Bowe, Paul D; Butler, Eoin; Cesar, Claudio L; Chapman, Steven; Charlton, Michael; Deller, A; Eriksson, S; Fajans, Joel; Friesen, Tim; Fujiwara, Makoto C; Gill, David R; Gutierrez, A; Hangst, Jeffrey S; Hardy, Walter N; Hayden, Michael E; Humphries, Andrew J; Hydomako, Richard; Jonsell, Svante; Madsen, Niels; Menary, Scott; Nolan, Paul; Olin, Art; Povilus, Alexander; Pusa, Petteri; Robicheaux, Francis; Sarid, Eli; Silveira, Daniel M; So, Chukman; Storey, James W; Thompson, Robert I; van der Werf, Dirk P; Wurtele, Jonathan S; Yamazaki, Yasunori

    2011-01-01

    Charges in cold, multiple-species, non-neutral plasmas separate radially by mass, forming centrifugally-separated states. Here, we report the first detailed measurements of such states in an electron-antiproton plasma, and the first observations of the separation dynamics in any centrifugally-separated system. While the observed equilibrium states are expected and in agreement with theory, the equilibration time is approximately constant over a wide range of parameters, a surprising and as yet unexplained result. Electron-antiproton plasmas play a crucial role in antihydrogen trapping experiments.

  3. Antiproton and proton collisions with the alkali-metal atoms Li, Na, and K

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2008-01-01

    Single-electron ionization and excitation cross sections as well as cross sections for excitation into the first excited p state of the alkali-metal atoms Li(2s), Na(3s), and K(4s) colliding with antiprotons and protons were calculated using a time-dependent channel-coupling approach....... For antiprotons an impact-energy range from 0.25 to 1000 keV and for protons from 2 to 1000 keV was considered. The target atoms are treated as effective one-electron systems using a model potential. The results are compared with theoretical and experimental data from literature and calculated cross sections...

  4. Baryon fraction in the universe, antiproton lifetime, and the diffuse radiation

    Energy Technology Data Exchange (ETDEWEB)

    Stephens, S.A. [Tata Institute of Fundamental Research, Homi Bhabha Road, Bombay 400005 (India); Finetti, N. [Particle Astrophysics Laboratory, New Mexico State University, Las Cruces, New Mexico 88003 (United States)

    1995-07-01

    We have calculated the diffuse spectrum in the energy region between 0.1 keV and 500 MeV, which arises from the decay of antiprotons in the baryon Symmetric Universe. Comparing this with the observation, we derived a life time of {gt}2.3{times}10 {sup 24} sec for the antiproton, which is 17 orders better than the one determined from laboratory experiments. We predict a cut-off in the diffuse radiation beyond 460 MeV, and if seen, would provide evidence for the existence of antimatter domains in the universe. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  5. Single ionization of helium by 40--3000-keV antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, L.H.; Hvelplund, P.; Knudsen, H.; Moller, S.P.; Pedersen, J.O.P.; Tang-Petersen, S.; Uggerhoj, E. (Institute of Physics, University of Aarhus, DK-8000 Aarhus C (Denmark)); Elsener, K. (CERN, CH-1211 Geneva (Switzerland)); Morenzoni, E. (PSI, CH-5234 Villigen (Switzerland))

    1990-06-01

    Measurements of single-ionization cross sections for antiproton impact on helium atoms are reported for impact energies ranging from 40 keV to 3 MeV. It is found that the measured cross sections are in good agreement with recent theoretical estimates based on the continuum-distorted-wave approximation. From a comparison with similar proton data, the ratio between antiproton and proton results is obtained. The energy dependence of this ratio is compared with various theoretical estimates and explained as a result of polarization and binding effects.

  6. Single ionization of helium by 40-3000-keV antiprotons

    Science.gov (United States)

    Andersen, L. H.; Hvelplund, P.; Knudsen, H.; Møller, S. P.; Pedersen, J. O. P.; Tang-Petersen, S.; Uggerhøj, E.; Elsener, K.; Morenzoni, E.

    1990-06-01

    Measurements of single-ionization cross sections for antiproton impact on helium atoms are reported for impact energies ranging from 40 keV to 3 MeV. It is found that the measured cross sections are in good agreement with recent theoretical estimates based on the continuum-distorted-wave approximation. From a comparison with similar proton data, the ratio between antiproton and proton results is obtained. The energy dependence of this ratio is compared with various theoretical estimates and explained as a result of polarization and binding effects.

  7. Operating Procedure Changes to Improve Antiproton Production at the Fermilab Tevatron Collider

    Energy Technology Data Exchange (ETDEWEB)

    Drendel, B.; Morgan, J.P.; Vander Meulen, D.; /Fermilab

    2009-04-01

    Since the start of Fermilab Collider Run II in 2001, the maximum weekly antiproton accumulation rate has increased from 400 x 10{sup 10} Pbars/week to approximately 3,700 x 10{sup 10} Pbars/week. There are many factors contributing to this increase, one of which involves changes to operational procedures that have streamlined and automated Antiproton Source production. Automation has been added to the beam line orbit control, stochastic cooling power level management, and RF settings. In addition, daily tuning efforts have been streamlined by implementing sequencer driven tuning software.

  8. Depth-Dose and LET Distributions of Antiproton Beams in Various Target Materials

    DEFF Research Database (Denmark)

    Herrmann, Rochus; Olsen, Sune; Petersen, Jørgen B.B.;

    unrestricted LET is calculated for all configurations. Finally, we investigate which concentrations of gadolinium and boron are needed in a water target in order to observe a significant change in the antiproton depth-dose distribution.  Results Results indicate, that there is no significant change...... in the depth-dose distribution and average LET when substituting the materials. Adding boron and gadolinium up to concentrations of 1 per 1000 atoms to a water phantom, did not change the depth-dose profile nor the average LET. Conclusions  According to our FLUKA calculations, antiproton neutron capture...

  9. Pion, Kaon, Proton and Antiproton Production in Proton-Proton Collisions

    Science.gov (United States)

    Norbury, John W.; Blattnig, Steve R.

    2008-01-01

    Inclusive pion, kaon, proton, and antiproton production from proton-proton collisions is studied at a variety of proton energies. Various available parameterizations of Lorentz-invariant differential cross sections as a function of transverse momentum and rapidity are compared with experimental data. The Badhwar and Alper parameterizations are moderately satisfactory for charged pion production. The Badhwar parameterization provides the best fit for charged kaon production. For proton production, the Alper parameterization is best, and for antiproton production the Carey parameterization works best. However, no parameterization is able to fully account for all the data.

  10. Evidence for a Possible Proton-Antiproton Bound State from Lattice QCD

    CERN Document Server

    Loan, M

    2006-01-01

    We have used standard techniques of lattice quantum chromodynamics to look for evidence of the spin-zero six quark flavour singlet state ($J^{PC}=0^{-+}$) observed by BES Collaboration, and to determine the splitting between the mass of the possible proton-antiproton and the mass of two protons, its threshold. Ignoring quark loops and quark annihilation, we find indications that for sufficiently light quarks proton- antiproton is below the $2m_{p}$ threshold, making it a possible six-quark bound state.

  11. Proton-Antiproton Pair Production in Two-Photon Collisions at LEP

    CERN Document Server

    Achard, P; Aguilar-Benítez, M; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alviggi, M G; Anderhub, H; Andreev, V P; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Bajo, A; Baksay, G; Baksay, L; Baldew, S V; Banerjee, S; Banerjee, Sw; Barczyk, A; Barillère, R; Bartalini, P; Basile, M; Batalova, N; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Bellucci, L; Berbeco, R; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Biasini, M; Biglietti, M; Biland, A; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böhm, A; Boldizsar, L; Borgia, B; Bottai, S; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brochu, F; Burger, J D; Burger, W J; Cai, X D; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada, M; Chamizo-Llatas, M; Chang, Y H; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chiefari, G; Cifarelli, Luisa; Cindolo, F; Clare, I; Clare, R; Coignet, G; Colino, N; Costantini, S; de la Cruz, B; Cucciarelli, S; van Dalen, J A; De Asmundis, R; Déglon, P L; Debreczeni, J; Degré, A; Dehmelt, K; Deiters, K; Della Volpe, D; Delmeire, E; Denes, P; De Notaristefani, F; De Salvo, A; Diemoz, M; Dierckxsens, M; Dionisi, C; Dittmar, M; Doria, A; Dova, M T; Duchesneau, D; Duda, M; Echenard, B; Eline, A; El-Hage, A; El-Mamouni, H; Engler, A; Eppling, F J; Extermann, P; Falagán, M A; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, M; Ferguson, T; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisher, W; Fisk, I; Forconi, G; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gataullin, M; Gentile, S; Giagu, S; Gong, Z F; Grenier, G; Grimm, O; Grünewald, M W; Guida, M; van Gulik, R; Gupta, V K; Gurtu, A; Gutay, L J; Haas, D; Hakobyan, R S; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Hirschfelder, J; Hofer, H; Hohlmann, M; Holzner, G; Hou, S R; Hu, Y; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Käfer, D; Kaur, M; Kienzle-Focacci, M N; Kim, J K; Kirkby, Jasper; Kittel, E W; Klimentov, A; König, A C; Kopal, M; Koutsenko, V F; Kräber, M H; Krämer, R W; Krüger, A; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Le Goff, J M; Leiste, R; Levtchenko, M; Levchenko, P M; Li, C; Likhoded, S; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lü, Y S; Luci, C; Luminari, L; Lustermann, W; Ma Wen Gan; Malgeri, L; Malinin, A; Maña, C; Mans, J; Martin, J P; Marzano, F; Mazumdar, K; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Mihul, A; Milcent, H; Mirabelli, G; Mnich, J; Mohanty, G B; Muanza, G S; Muijs, A J M; Musicar, B; Musy, M; Nagy, S; Natale, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Nisati, A; Nowak, H; Ofierzynski, R A; Organtini, G; Pal, I; Palomares, C; Paolucci, P; Paramatti, R; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Pedace, M; Pensotti, S; Perret-Gallix, D; Petersen, B; Piccolo, D; Pierella, F; Pioppi, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Pothier, J; Prokofev, D; Prokofiev, D O; Quartieri, J; Rahal-Callot, G; Rahaman, M A; Raics, P; Raja, N; Ramelli, R; Rancoita, P G; Ranieri, R; Raspereza, A V; Razis, P A; Ren, D; Rescigno, M; Reucroft, S; Riemann, S; Riles, K; Roe, B P; Romero, L; Rosca, A; Rosier-Lees, S; Roth, S; Rosenbleck, C; Rubio, J A; Ruggiero, G; Rykaczewski, H; Sakharov, A; Saremi, S; Sarkar, S; Salicio, J; Sánchez, E; Schäfer, C; Shchegelskii, V; Schopper, Herwig Franz; Schotanus, D J; Sciacca, C; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shumilov, E; Shvorob, A V; Son, D; Souga, C; Spillantini, P; Steuer, M; Stickland, D P; Stoyanov, B; Strässner, A; Sudhakar, K; Sultanov, G G; Sun, L Z; Sushkov, S; Suter, H; Swain, J D; Szillási, Z; Tang, X W; Tarjan, P; Tauscher, Ludwig; Taylor, L; Tellili, B; Teyssier, D; Timmermans, C; Ting, Samuel C C; Ting, S M; Tonwar, S C; Tóth, J; Tully, C; Tung, K L; Ulbricht, J; Valente, E; Van de Walle, R T; Vásquez, R; Veszpremi, V; Vesztergombi, G; Vetlitskii, I; Vicinanza, D; Viertel, Gert M; Villa, S; Vivargent, M; Vlachos, S; Vodopyanov, I; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Wadhwa, M; Wang, Q; Wang, X L; Wang, Z M; Weber, M; Wienemann, P; Wilkens, H; Wynhoff, S; Xia, L; Xu, Z Z; Yamamoto, J; Yang, B Z; Yang, C G; Yang, H J; Yang, M; Yeh, S C; Zalite, A; Zalite, Yu; Zhang, Z P; Zhao, J; Zhu, G Y; Zhu, R Y; Zhuang, H L; Zichichi, A; Zimmermann, B; Zöller, M

    2003-01-01

    The reaction e+e- -> e+e- proton antiproton is studied with the L3 detector at LEP. The analysis is based on data collected at e+e- center-of-mass energies from 183 GeV to 209 GeV, corresponding to an integrated luminosity of 667 pb-1. The gamma gamma -> proton antiproton differential cross section is measured in the range of the two-photon center-of-mass energy from 2.1 GeV to 4.5 GeV. The results are compared to the predictions of the three-quark and quark-diquark models.

  12. Peripheral intravenous line (image)

    Science.gov (United States)

    A peripheral intravenous line is a small, short plastic catheter that is placed through the skin into a vein, ... or foot, but occasionally in the head. A peripheral intravenous line is used to give fluids and ...

  13. Peripheral arterial line (image)

    Science.gov (United States)

    A peripheral arterial line is a small, short plastic catheter placed through the skin into an artery of the arm or leg. The purpose of a peripheral arterial line is to allow continuous monitoring of ...

  14. Malignant Peripheral Nerve Sheath Tumour of the Maxilla

    Directory of Open Access Journals (Sweden)

    Puja Sahai

    2014-01-01

    Full Text Available A 38-year-old man was diagnosed with malignant peripheral nerve sheath tumour of the maxilla. He was treated with total maxillectomy. Histopathological examination of the resected specimen revealed a close resection margin. The tumour was of high grade with an MIB-1 labelling index of almost 60%. At six weeks following the surgery, he developed local tumour relapse. The patient succumbed to the disease at five months from the time of diagnosis. The present report underlines the locally aggressive nature of malignant peripheral nerve sheath tumour of the maxilla which necessitates an early therapeutic intervention. A complete resection with clear margins is the most important prognostic factor for malignant peripheral nerve sheath tumour in the head and neck region. Adjuvant radiotherapy may be considered to improve the local control. Future research may demarcate the role of targeted therapy for patients with malignant peripheral nerve sheath tumour.

  15. Plan optimization for stereotactic radiotherapy

    NARCIS (Netherlands)

    J.A. de Pooter (Jacobus Abraham)

    2008-01-01

    textabstractCancer is one of the leading causes of death in the world. Next to surgery and chemotherapy, radiotherapy is one of the most used treatment modalities for cancer. About 50% of the patients with cancer will be treated with radiotherapy during the management of their disease. In radiothera

  16. The Confluence of Radiotherapy & Immunotherapy

    Directory of Open Access Journals (Sweden)

    Ralph Robert Weichselbaum

    2012-10-01

    Full Text Available Radiotherapy has been considered a local modality and outcomes have emphasized local and regional control of tumors. Recent data suggests that radiotherapy may activate the immune system and the combination of radiation therapy and immune therapies may have the potential to improve both local and distant control of tumor deposits. Below we review principals underlying the concepts of combining both modalities.

  17. Propylthiouracil and peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    Valentina Van Boekel

    1992-06-01

    Full Text Available Peripheral neuropathy is a rare manifestation in hyperthyroidism. We describe the neurological manifestations of a 38 year old female with Graves' disease who developed peripheral neuropathy in the course of her treatment with propylthiouracil. After the drug was tapered off, the neurological signs disappeared. Therefore, we call attention for a possible toxic effect on peripheral nervous system caused by this drug.

  18. Radiotherapy of benign diseases

    Energy Technology Data Exchange (ETDEWEB)

    Haase, W.

    1982-10-11

    Still today radiotherapy is of decisive relevance for several benign diseases. The following ones are briefly described in this introductory article: 1. Certain inflammatory and degenerative diseases as furuncles in the face, acute thrombophlebitis, recurrent pseudoriparous abscesses, degenerative skeletal diseases, cervical syndrome and others; 2. rheumatic joint diseases; 3. Bechterew's disease; 4. primary presenile osteoporosis; 5. syringomyelia; 6. endocrine ophthalmopathy; 7. hypertrophic processes of the connective tissue; 8. hemangiomas. A detailed discussion and a profit-risk analysis is provided in the individual chapters of the magazine.

  19. Buffer-gas cooling of antiprotonic helium to 1.5 to 1.7 K, and antiproton-to–electron mass ratio

    CERN Document Server

    Hori, Masaki; Sótér, Anna; Barna, Daniel; Dax, Andreas; Hayano, Ryugo; Kobayashi, Takumi; Murakami, Yohei; Todoroki, Koichi; Yamada, Hiroyuki; Horváth, Dezső; Venturelli, Luca

    2016-01-01

    Charge, parity, and time reversal (CPT) symmetry implies that a particle and its antiparticle have the same mass. The antiproton-to-electron mass ratio Embedded Image can be precisely determined from the single-photon transition frequencies of antiprotonic helium. We measured 13 such frequencies with laser spectroscopy to a fractional precision of 2.5 × 10−9 to 16 × 10−9. About 2 × 109 antiprotonic helium atoms were cooled to temperatures between 1.5 and 1.7 kelvin by using buffer-gas cooling in cryogenic low-pressure helium gas; the narrow thermal distribution led to the observation of sharp spectral lines of small thermal Doppler width. The deviation between the experimental frequencies and the results of three-body quantum electrodynamics calculations was reduced by a factor of 1.4 to 10 compared with previous single-photon experiments. From this, Embedded Image was determined as 1836.1526734(15), which agrees with a recent proton-to-electron experimental value within 8 × 10−10.

  20. Measurement of 0.25-3.2 GeV antiprotons in the cosmic radiation

    DEFF Research Database (Denmark)

    Mitchell, J.W.; Barbier, L.M.; Christian, E.R.;

    1996-01-01

    The balloon-borne Isotope Matter-Antimatter Experiment (IMAX) was flown from Lynn Lake, Manitoba, Canada on 16-17 July 1992. Using velocity and magnetic rigidity to determine mass, we have directly measured the abundances of cosmic ray antiprotons and protons in the energy range from 0.25 to 3.2 ...

  1. Collisions of low-energy antiprotons with molecular hydrogen: ionization, excitation and stopping power

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2009-01-01

    A time-dependent coupled-channel approach was used to calculate ionization, excitation, and energy-loss cross sections as well as energy spectra for antiproton and proton collisions with molecular hydrogen for impact energies 8 < E < 4000 keV....

  2. Relative Biological Effect of Antiprotons

    DEFF Research Database (Denmark)

    Bassler, Niels; Holzscheiter, Michael

    nuclear research facility CERN. A beam of 126 MeV antiprotons, corresponding to about 12 cm range in water, was spread out to a SOBP with a width of 1 cm. Dosimetry experiments were carried out with ionization chambers, alanine pellets and radiochromic film, and the results were used for benchmarking...

  3. S142 set-up to detect X-ray from antiproton-proton atoms (protonium).

    CERN Multimedia

    1978-01-01

    This experiment was designed by the Daresbury-Mainz-TRIUMF Collaboration and was located in the m14 partially separated antiproton beam in the PS South Hall. It used a gaseous hydrogen target, 1 m long, surrounded by a ring of proportional counters, surrounded in turn by a ring of 36 scintillators strips to aid in the annihilation product identification. Ugo Gastaldi (centre)

  4. Closing in on mass-degenerate dark matter scenarios with antiprotons and direct detection

    Energy Technology Data Exchange (ETDEWEB)

    Garny, Mathias [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ibarra, Alejandro; Pato, Miguel; Vogl, Stefan [Technische Univ. Muenchen, Garching (Germany). Physik-Department

    2012-07-15

    Over the last years both cosmic-ray antiproton measurements and direct dark matter searches have proved particularly effective in constraining the nature of dark matter candidates. The present work focusses on these two types of constraints in a minimal framework which features a Majorana fermion as the dark matter particle and a scalar that mediates the coupling to quarks. Considering a wide range of coupling schemes, we derive antiproton and direct detection constraints using the latest data and paying close attention to astrophysical and nuclear uncertainties. Both signals are strongly enhanced in the presence of degenerate dark matter and scalar masses, but we show that the effect is especially dramatic in direct detection. Accordingly, the latest direct detection limits take the lead over antiprotons. We find that antiproton and direct detection data set stringent lower limits on the mass splitting, reaching 19% at a 300 GeV dark matter mass for a unity coupling. Interestingly, these limits are orthogonal to ongoing collider searches at the Large Hadron Collider, making it feasible to close in on degenerate dark matter scenarios within the next years.

  5. Antiproton-to-proton ratios for ALICE heavy-ion collisions

    Energy Technology Data Exchange (ETDEWEB)

    Tawfik, A., E-mail: atawfik@cern.ch [Egyptian Center for Theoretical Physics (ECTP), MTI University, Cairo (Egypt)

    2011-06-01

    Assuming that the final state of hadronization takes place along the freezeout line, which is defined by a constant entropy density, the antiproton-to-proton ratios produced in heavy-ion collisions are studied in framework of the hadron resonance gas (HRG) model. A phase transition from quark-gluon plasma to hadrons, a hadronization, has been conjectured in order to allow modifications in the phase-space volume and thus in the single-particle distribution function. Implementing both modifications in the grand-canonical partition function and taking into account the experimental acceptance in the heavy-ion collisions, the antiproton-to-proton ratios over center-of-mass energies {radical}(s) ranging from AGS to RHIC are very well reproduced by the HRG model. Comparing with the same particle ratios in pp collisions results in a gradually narrowing discrepancy with increasing {radical}(s). At LHC energy, the ALICE antiproton-to-proton ratios in the pp collisions turn to be very well described by the HRG model as well. It is likely that the ALICE AA-program will produce the same antiproton-to-proton ratios as the pp-one. Furthermore, the ratio gets very close to unity indicating that the matter-antimatter asymmetry nearly vanishes. The chemical potential calculated at this energy strengthens the assumption of almost fully matter-antimatter symmetry up to the LHC energy.

  6. Status Report for Experiment AD-4/ACE Biological Effectiveness of Antiproton Annihilation

    CERN Document Server

    Holzscheiter, M H; Angelopoulos, Angelo; Bassler, Niels; Beyer, Gerd; Currell, Fred; De Marco, John; Doser, Michael; Hajdukovic, Dragan; Hartley, Oliver; Kavanagh, Joy; Iwamoto, Kei; Jäkel, Oliver; Kantemiris, Ioannis; Knudsen, Helge; Kovacevic, Sandra; McBride, Bill; Møller, Søren Pape; Overgaard, Jens; Petersen, Jørgen; Ratib, Osman; Schettino, Giuseppe; Timson, David; Singers-Sørensen, Brita; Solberg, Timothy; Vranjes, Sanja; Wouters, Brad

    2009-01-01

    Status report for experiment AD-4/ACE showing recent progress in RBE measurements for V79 Chinese Hamster cells irradiated with antiprotons. Also discussed are initial test experiments using the H2AX assay to study DNA damage to cells and initial experiments using liquid ionization chambers.

  7. Antiproton-nucleus interactions at 5 to 9 GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Ahmad, S. (T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States)); Bonner, B.E. (T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States)); Buchanan, J.A. (T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States)); Chan, C.S. (City Coll. of New York, NY (United States)); Clement, J.M. (T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States)); Eiseman, S.E. (Brookhaven National Lab., Upton, NY (United States)); Empl, A. (T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States)); Etkin, A. (Brookhaven National Lab., Upton, NY (United States)); Foley, K.J. (Brookhaven National Lab., Upton, NY (United States)); Hackenburg, R.W. (Brookhaven National Lab., Upton, NY (United States)); Hallman, T.J. (Johns Hopkins Univ., Baltimore, MD (United States)); Kramer, M.A. (City Coll. of New York, NY (United States)); Kruk, J. (T.W. Bonner Nuclear Lab., Rice Univ., Houston, TX (United States)); Lindenbaum, S.J. (City Coll. of New York, NY (; E854 Collaboration

    1993-06-07

    Antiproton beams of 5, 7 and 9 GeV/c were used to interact with C, Al, Cu, Sn and Pb nuclear targets. Charged particle multiplicity distributions, strange particle production cross sections and rapidity distributions were measured. The charged particle multiplicities are reported in this paper. (orig.)

  8. Breast cancer radiotherapy: controversies and prospectives

    Institute of Scientific and Technical Information of China (English)

    YU Jin-ming; WANG Yong-sheng

    2008-01-01

    @@ Despite consensus on breast cancer radiotherapy, there are still some controversies over post-mastectomy radiotherapy (PMRT) in patients with 1-3 positive lymph nodes, accelerated partial breast irradiation (APBI), appropriate sequence of radiotherapy, chemotherapy and hormonal treatment, and radiotherapy after preoperative systemic therapy.

  9. Report of the Snowmass T4 working group on particle sources: Positron sources, anti-proton sources and secondary beams

    Energy Technology Data Exchange (ETDEWEB)

    N. Mokhov et al.

    2002-12-05

    This report documents the activities of the Snowmass 2001 T4 Particle Sources Working Group. T4 was charged with examining the most challenging aspects of positron sources for linear colliders and antiproton sources for proton-antiproton colliders, and the secondary beams of interest to the physics community that will be available from the next generation of high-energy particle accelerators. The leading issues, limiting technologies, and most important R and D efforts of positron production, antiproton production, and secondary beams are discussed in this paper. A listing of T4 Presentations is included.

  10. On Antiproton Production in 158 GeV/c Proton-Carbon Collisions and Nuclear Temperature of Interacting System

    Directory of Open Access Journals (Sweden)

    Fu-Hu Liu

    2013-01-01

    Full Text Available The multisource thermal model is used in this paper to analyze the antiproton (p¯ production process in high-energy proton-carbon (p-C collisions. The transverse momentum, Feynman variable, and rapidity distributions of antiprotons in the nucleon-nucleon center-of-mass system are calculated by using the model. The modeling results are compared and found to be in agreement with the experimental data measured by the NA49 Collaboration at 158 GeV/c beam momentum. As a parameter, the nuclear temperature of interacting system extracted from the antiproton spectrum is estimated to be about 150 MeV.

  11. Adaptive Motion Compensation in Radiotherapy

    CERN Document Server

    Murphy, Martin J

    2011-01-01

    External-beam radiotherapy has long been challenged by the simple fact that patients can (and do) move during the delivery of radiation. Recent advances in imaging and beam delivery technologies have made the solution--adapting delivery to natural movement--a practical reality. Adaptive Motion Compensation in Radiotherapy provides the first detailed treatment of online interventional techniques for motion compensation radiotherapy. This authoritative book discusses: Each of the contributing elements of a motion-adaptive system, including target detection and tracking, beam adaptation, and pati

  12. Experimental determination of the complete spin structure for anti-proton + proton -> anti-\\Lambda + \\Lambda at anti-proton beam momentum of 1.637 GeV/c

    CERN Document Server

    Paschke, K D; Berdoz, A; Franklin, G B; Khaustov, P; Meyer, C A; Bradtke, C; Gehring, R; Görtz, S; Harmsen, J; Meier, A; Meyer, W; Radtke, E; Reicherz, G; Dutz, H; Plückthun, M; Schoch, B; Dennert, H; Eyrich, W; Hauffe, J; Metzger, A; Moosburger, M; Stinzing, F; Wirth, S; Fischer, H; Franz, J; Heinsius, F H; Kriegler, E; Schmitt, H; Bunker, B; Hertzog, D; Jones, T; Tayloe, R; Bröders, R; Geyer, R; Kilian, K; Oelert, W; Röhrich, K; Sachs, K; Sefzick, T; Bassalleck, B; Eilerts, S; Fields, D E; Kingsberry, P; Lowe, J; Stotzer, R; Johansson, T; Pomp, S; Wirth, St.

    2006-01-01

    The reaction anti-proton + proton -> anti-\\Lambda + \\Lambda -> anti-proton + \\pi^+ + proton + \\pi^- has been measured with high statistics at anti-proton beam momentum of 1.637 GeV/c. The use of a transversely-polarized frozen-spin target combined with the self-analyzing property of \\Lambda/anti-\\Lambda decay allows access to unprecedented information on the spin structure of the interaction. The most general spin-scattering matrix can be written in terms of eleven real parameters for each bin of scattering angle, each of these parameters is determined with reasonable precision. From these results all conceivable spin-correlations are determined with inherent self-consistency. Good agreement is found with the few previously existing measurements of spin observables in anti-proton + proton -> anti-\\Lambda + \\Lambda near this energy. Existing theoretical models do not give good predictions for those spin-observables that had not been previously measured.

  13. Scientific calculating peripheral

    Energy Technology Data Exchange (ETDEWEB)

    Ethridge, C.D.; Nickell, J.D. Jr.; Hanna, W.H.

    1979-09-01

    A scientific calculating peripheral for small intelligent data acquisition and instrumentation systems and for distributed-task processing systems is established with a number-oriented microprocessor controlled by a single component universal peripheral interface microcontroller. A MOS/LSI number-oriented microprocessor provides the scientific calculating capability with Reverse Polish Notation data format. Master processor task definition storage, input data sequencing, computation processing, result reporting, and interface protocol is managed by a single component universal peripheral interface microcontroller.

  14. Stereotactic radiotherapy for vestibular schwannoma

    DEFF Research Database (Denmark)

    Muzevic, Dario; Legcevic, Jelena; Splavski, Bruno;

    2014-01-01

    ; Web of Science; CAB Abstracts; ISRCTN and additional sources for published and unpublished trials. The date of the search was 24 July 2014. SELECTION CRITERIA: Randomised controlled trials (RCTs) exploring the efficacy of stereotactic radiotherapy compared with observation alone, microsurgical...

  15. Instrumentation for measurement of in-flight annihilations of 130 keV antiprotons on thin target foils

    Science.gov (United States)

    Todoroki, K.; Barna, D.; Hayano, R. S.; Aghai-Khozani, H.; Sótér, A.; Corradini, M.; Leali, M.; Lodi-Rizzini, E.; Mascagna, V.; Venturelli, L.; Prest, V.; Vallazza, L.; De Salvador, D.; Hori, M.

    2016-11-01

    We describe the instrumentation for an experiment to measure the cross sections of antiprotons with kinetic energies of 130±10 keV annihilating on carbon, palladium, and platinum target foils of sub-100 nm thicknesses. A 120 ns long pulsed beam containing 105 -106 antiprotons was allowed to traverse the foils, and the signal annihilations that resulted from this were isolated using a time-of-flight method. Backgrounds arose from Rutherford scattering of the antiprotons off the target foils, their annihilations in the target chamber walls, and π → μ → e decay of the charged pions that emerged from the annihilations. Some antiprotons slowed down and annihilated in the contamination on the target surfaces. This reduced the signal-to-background ratio of the measurement.

  16. Determination of the antiproton-to-electron mass ratio by precision laser spectroscopy of $\\overline{p}He^{+}$

    CERN Document Server

    Hori, M; Eades, John; Gomikawa, K; Hayano, R S; Ono, N; Pirkl, Werner; Widmann, E; Torii, H A; Juhász, B; Barna, D; Horváth, D

    2006-01-01

    A femtosecond optical frequency comb and continuous-wave pulse- amplified laser were used to measure 12 transition frequencies of antiprotonic helium to fractional precisions of (9-16) 10/sup -9lifetimes hitherto unaccessible to our precision laser spectroscopy method. Comparisons with three-body QED calculations yielded an antiproton-to-electron mass ratio of M/sub pmacron//m/sub e/=1836.152 674(5).

  17. Radioprotectors in Radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Nair, C.K.K. [Bhabha Atomic Research Centre, Mumbai (India); Parida, D.K.; Nomura, Taisei

    2001-03-01

    This review article focuses on clinically relevant radioprotectors and their mechanisms of radioprotection. Radiotherapy is the most common modality of human cancer therapy. Obtaining optimal results requires a judicious balance between the total dose of radiotherapy delivered and the threshold limit of critical surrounding normal tissues, and the normal tissues need to be protected against radiation injury to obtain better tumor control by using a higher dose. For this reason, radiation-protective agents play an important role in clinical radiotherapy. Radiation-protective agents can be classified into three groups: radioprotectors, adaptogens, and absorbents. The first group generally consists of sulfhydryl compounds and other antioxidants. They include several myelo-, entero-, and cerebro-protectors. Adaptogens act as promotors of radioresistance. They are natural protectors that offer chemical protection against low levels of ionizing radiation. Absorbents protect organs from internal radiation and chemicals. They include drugs that prevent incorporation of radioiodine by the thyroid gland and absorption of radionuclides. This article thoroughly describes the properties, mechanisms of action, and perspectives on clinical application of the following categories of radioprotectors: sulfhydryl compounds (e.g., cysteine, cysteamine, glutathione, AET, WR 2127, and other WR-compounds), antioxidants (e.g., tempace, Hoechst 33342, vitamin A, E, and C, TMG, melatonin), angiotensin-converting enzyme (ACE) inhibitors (e.g., captopril, elanopril, penicillamine, pentoxifylline, L-158, 809), cytoprotective agents (mesna, dexrazoxane, and amifostin), metalloelements (e.g., manganese chloride, cadmium salts, bismuth subnitrate), immunomodulators (gamma-interferon, polysaccharides AM5, AM218, heat-killed lactobacillus cells, broncho-vaxom, trehalose dicorynomycolate, and AS101), lipopolysaccharides and prostaglandins, plant extracts and compounds isolated from plants (curcmin

  18. Peripheral Ossifying Fibroma

    Directory of Open Access Journals (Sweden)

    Sudhakar S

    2009-11-01

    Full Text Available Peripheral ossifying fibroma is a relatively uncommon gingival growth that is considered to be reactive in nature and postulated to appear secondary to irritation or trauma. They usually occur in young adults with a female predominance and are solitary in nature. We report a case of peripheral ossifying fibroma in a 55-year old female.

  19. Vasculitic peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    Mona Amini

    2014-02-01

    Full Text Available Primary systemic vasculitis in pre-capillary arteries is associated with peripheral neuropathy. In some types of systematic vasculitis about 60 % of patients have peripheral nervous system (PNS involvement. In vasculitic peripheral neuropathies (VPN a necrotizing and inflammatory process leads to narrowing of vasa nervorum lumen and eventually the appearance of ischemic lesions in peripheral nerves. Some features might be suggestive of VPN, like: axonal nerve degeneration, wallerian-like degeneration, and diameter irregularity of nerve. Peripheral nervous system (PNS destruction during systemic vasculitides should be considered, due to its frequency and early occurrence in vasculitis progression. The first line treatment of non systematic VPNs is corticosteroid agents, but these drugs might worsen the VPNs or systemic vasculitis.

  20. Antihyperon potentials in nuclei via exclusive antiproton-nucleus reactions at FAIR

    CERN Document Server

    Lorente, Alicia Sanchez; Steinen, Marcell; Pochodzalla, Josef

    2015-01-01

    The exclusive production of hyperon-antihyperon pairs close to their production threshold in antiproton - nucleus collisions offers a unique and hitherto unexplored opportunity to elucidate the behaviour of antihyperons in nuclei. For the first time we analyse these reactions in a microscopic transport model using the the Gie\\ss en Boltzmann-Uehling-Uhlenbeck transport model. The calculation take the delicate interplay between the strong absorption of antihyperons, their rescattering and refraction at the nuclear surface as well as the Fermi motion of the struck nucleon into account. We find a substantial sensitivity of transverse momentum correlations of coincident $\\Lambda\\overline{\\Lambda}$-pairs to the assumed depth of the $\\overline{\\Lambda}$-potential. Because of the high cross section for this process and the simplicity of the experimental method our results are highly relevant for future activities at the international Facility for Antiproton and Ion Research (FAIR).

  1. The antiproton interaction with an internal 12C target inside the HESR ring at FAIR

    Science.gov (United States)

    Introzzi, R.; Balestra, F.; Lavagno, A.; Scozzi, F.; Younis, H.

    2016-04-01

    In order to fulfill the goal of producing higher rates of doubly strange hyperons, the P¯ANDA collaboration will use the antiproton ring HESR at the future facility FAIR. The low energy hyperon production by an antiproton beam requires to insert a solid target inside the ring. Unwanted side effects of such an insertion are the overwhelming amount of annihilations, which would make the detectors blind, and the fast depletion of the bunch, which circulates inside the ring. The choice of the target material impacts the hyperon production yield: Carbon turned out to provide enough initial hyperon deceleration and keep secondary interactions below a tolerable level. The use of a very thin Diamond target, together with beam steering techniques, seems to be a satisfactory solution to the above problems and will be described hereafter.

  2. Antiproton-proton Annihilation Into Two Mesons: The Role Of Relativistic Distortion

    CERN Document Server

    El-Bennich, B O

    2004-01-01

    The more than a decade old data on differential cross sections and analyzing powers in antiproton-proton annihilation into two pions (or two kaons), measured at the Low Energy Antiproton Ring (LEAR) of CERN, have stimulated several theoretical investigations. A characteristic feature of the data are the large variations of the scattering observables as a function of the scattering angle and of the laboratory energy already below 100 MeV. Amplitude analyzes reproduce the data with few partial waves (J ≤ 4) and one concludes that the annihilation process is very short- ranged and of the order of the nucleon size. Nonetheless, early models, using either baryonic or quark degrees of freedom, give rise to an even shorter antibaryon-baryon interaction failing to produce substantial higher (J ≥ 2) partial wave amplitudes and consequently to adequately describe the LEAR data. In this thesis, we systematically consider improvements within the framework of quark-line diagrams. We first derive various quar...

  3. Secondary emission monitor for keV ion and antiproton beams

    CERN Document Server

    Sosa, Alejandro; Bravin, Enrico; Harasimowciz, Janusz; Welsch, C P

    2013-01-01

    Beam profile monitoring of low intensity keV ion and antiproton beams remains a challenging task. A Sec- ondary electron Emission Monitor (SEM) has been de- signed to measure profiles of beams with intensities below 107 and energies as low as 20 keV. The monitor is based on a two stage microchannel plate (MCP) and a phosphor screen facing a CCD camera. Its modular design allows two different operational setups. In this contribution we present the design of a prototype and discuss results from measurements with antiprotons at the AEgIS experiment at CERN. This is then used for a characterization of the monitor with regard to its possible future use at different facilities.

  4. Further studies of double ionization of He, Ne, and Ar by fast and slow antiprotons

    Science.gov (United States)

    Andersen, L. H.; Hvelplund, P.; Knudsen, H.; Møller, S. P.; Pedersen, J. O. P.; Tang-Petersen, S.; Uggerhøj, E.; Elsener, K.; Morenzoni, E.

    1989-12-01

    Measurements of the ratio R between double- and single-ionization cross sections for antiproton impact on He, Ne, and Ar targets are reported for impact energies ranging from 65 keV to 20 MeV. At high energies the results are found to merge with proton results at around 20 MeV, and the high-energy limit of the common ratio is in good agreement with recent first-Born-calculation results for the helium target. The large difference previously observed in the ratio R for protons and antiprotons at energies between 0.5 and 5 MeV is found to persist down to the lowest energies investigated here.

  5. Further studies of double ionization of He, Ne, and Ar by fast and slow antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, L.H.; Hvelplund, P.; Knudsen, H.; Moller, S.P.; Pedersen, J.O.P.; Tang-Petersen, S.; Uggerhoj, E. (Institute of Physics, University of Aarhus, DK-8000 Aarhus C, Denmark (Denmark)); Elsener, K. (CERN, CH-1211 Geneva 23, (Switzerland)); Morenzoni, E. (PSI, CH-5234 Villigen, (Switzerland))

    1989-12-15

    Measurements of the ratio {ital R} between double- and single-ionization cross sections for antiproton impact on He, Ne, and Ar targets are reported for impact energies ranging from 65 keV to 20 MeV. At high energies the results are found to merge with proton results at around 20 MeV, and the high-energy limit of the common ratio is in good agreement with recent first-Born-calculation results for the helium target. The large difference previously observed in the ratio {ital R} for protons and antiprotons at energies between 0.5 and 5 MeV is found to persist down to the lowest energies investigated here.

  6. A Cryogenic Current Comparator for the Low Energy Antiproton Facilities at CERN

    CERN Document Server

    Fernandes, M; Welsch, CP

    2014-01-01

    Several laboratories have shown the potential of using Superconducting QUantum Interference Device (SQUID) magnetometers together with superconductor magnetic shields to measure beam current intensities in the submicro-Ampere regime. CERN, in collaboration with GSI, Jena university and Helmholtz Institute Jena, is currently working on developing an improved version of such a current monitor for the Antiproton Decelerator (AD) and Extra Low ENergy Antiproton (ELENA) rings at CERN, aiming for better current resolution and overall system availability. This contribution will present the current design, including theoretical estimation of the current resolution; stability limits of SQUID systems and adaptation of the coupling circuit to the AD beam parameters; the analysis of thermal and mechanical cryostat modes.

  7. 10 GeV dark matter candidates and cosmic-ray antiprotons

    CERN Document Server

    Lavalle, Julien

    2010-01-01

    Recent measurements performed with some direct dark matter detection experiments, e.g. CDMS-II and CoGENT (after DAMA/LIBRA), have unveiled a few events compatible with WIMP-nuclei interactions. The preferred mass range is around 10 GeV, with a quite large spin-independent cross section of $10^{-43}-10^{-41}\\,{\\rm cm^2}$. In this letter, we recall that a light WIMP with dominant couplings to quarks should also generate cosmic-ray antiprotons. Taking advantage of recent works constraining the Galactic dark matter mass profile on the one hand and on cosmic-ray propagation on the other hand, we point out that considering a thermal annihilation cross section for such low mass candidates unavoidably results in an antiproton flux in tension with the current data, leading either to exclusion or to observable features. This should be taken into account for a consistent interpretation of direct detection signals.

  8. First experimental detection of antiproton in-flight annihilation on nuclei at 130 keV

    CERN Document Server

    Aghai-Khozani, H; Corradini, M; Hayano, R; Hori, M; Kobayashi, T; Leali, M; Lodi-Rizzini, E; Mascagna, V; Prest, M; Soter, A; Todoroki, K; Vallazza, E; Venturelli, L; Zurlo, N

    2012-01-01

    The existing data of antinucleon-nucleon and antinucleon-nuclei annihilation cross-sections are confined to energies above about 1MeV. Experimental limitations have prevented till now the lower energies data to be achieved in spite of the interest they represent for theoretical models. One of the unresolved question concerns the antiproton annihilation cross-section measured at LEAR on light nuclei in the MeV region, which show a saturation with the mass number of the target nucleus against any naive expectation. With regard to fundamental cosmology, the knowledge of the annihilation cross-sections at energies below 1MeV can contribute to understand the matter-antimatter asymmetry in the Universe. We present here the experimental demonstration of the feasibility of the measurement of antiproton-nuclei annihilation cross-sections in the 100 keV region.

  9. Spectral Intensities of Antiprotons and the lifetime of Cosmic Rays in the Galaxy

    CERN Document Server

    Cowsik, Ramanath

    2015-01-01

    In this paper we note that the spectral intensities of antiprotons observed in Galactic cosmic rays in the energy range ~ 1-100 GeV by BESS, PAMELA and AMS instruments display nearly the same spectral shape as that generated by primary cosmic rays through their interaction with matter in the interstellar medium, without any significant modifications. More importantly, a constant residence time of ~ 2.5 +/-0.7 million years in the Galactic volume, independent of the energy of cosmic rays, matches the observed intensities. A small additional component of secondary antiprotons in the energy below 10 GeV, generated in cocoon-like regions surrounding the cosmic-ray sources, seems to be present. We discuss this result in the context of observations of other secondary components like positrons and Boron, and conclude with general remarks about the origins and propagation of cosmic rays.

  10. Investigation of silicon sensors for their use as antiproton annihilation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Pacifico, N., E-mail: nicola.pacifico@cern.ch [University of Bergen, Institute of Physics and Technology, Allégaten 55, 5007 Bergen (Norway); Aghion, S. [Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Milano, Via Celoria 16, 20133 Milano (Italy); Ahlén, O. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Belov, A.S. [Institute for Nuclear Research of the Russian Academy of Sciences, Moscow 117312 (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering, Via Branze 38, 25133 Brescia (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Pavia, Via Agostino Bassi 6, 27100 Pavia (Italy); Bräunig, P. [Kirchhoff Institute for Physics, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Department of Physics, University of Trento, via Sommarive 14, 38123 Povo, Trento (Italy); INFN-TIFPA, via Sommarive 14, 38123 Povo, Trento (Italy); Burghart, G. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Cabaret, L. [Laboratoire Aimé Cotton, CNRS, Université Paris Sud, ENS Cachan, Bâtiment 505, Campus d' Orsay, 91405 Orsay Cedex (France); Caccia, M. [University of Insubria, Dipartimento di Scienza ed Alta Tecnologia, via Valleggio 11, Como (Italy); Canali, C. [University of Zurich, Physics Institute, Winterthurerstrasse 190, 8057 Zurich (Switzerland); Caravita, R. [Istituto Nazionale di Fisica Nucleare, Sez. di Genova, Via Dodecaneso 33, 16146 Genova (Italy); University of Genoa, Department of Physics, Via Dodecaneso 33, 16146 Genova (Italy); Castelli, F. [University of Milano, Department of Physics, Via Celoria 16, 20133 Milano (Italy); and others

    2014-11-21

    We present here a new application of silicon sensors aimed at the direct detection of antinucleons annihilations taking place inside the sensor's volume. Such detectors are interesting particularly for the measurement of antimatter properties and will be used as part of the gravity measurement module in the AEg{sup ¯}IS experiment at the CERN Antiproton Decelerator. One of the goals of the AEg{sup ¯}IS experiment is to measure the gravitational acceleration of antihydrogen with 1% precision. Three different silicon sensor geometries have been tested with an antiproton beam to investigate their properties as annihilation detection devices: strip planar, 3D pixels and monolithic pixel planar. In all cases we were successfully detecting annihilations taking place in the sensor and we were able to make a first characterization of the clusters and tracks.

  11. Scattered antiproton polarization in pp elastic scattering at 220 MeV in bubble chamber

    CERN Document Server

    Ohsugi, T

    1973-01-01

    The polarization of antiproton scattering in pp elastic collision has been measured in the four intervals of the CM scattering angle theta /sup */ less than 90 degrees by means of double scattering in a bubble chamber. The analysis has been performed on the basis of 999 double elastic events which have been found in about 100K pictures of the 81- cm Saclay hydrogen bubble chamber exposed to a 0.7 GeV/c antiproton beam from the CERN PS. The obtained values of polarization show the maximum value 0.52+or-0.19 at theta /sup */=56 degrees . The polarization for pp scattering seems to be larger than that for pp scattering. The results are also compared with the potential model by Bryan and Phillips (1968) and with the modified diffraction model by Frahn and Venter (1964). Possible systematic errors in the present experiment are discussed in detail. (17 refs).

  12. Probing Matter Radii of Neutron-Rich Nuclei by Antiproton Scattering

    OpenAIRE

    Lenske, H.; P. Kienle

    2005-01-01

    We propose to use antiprotons to investigate the sizes of stable and neutron-rich exotic nuclei by measurements of the $\\pbar A$ absorption cross section along isotopic chains in inverse kinematics. The expected effects are studied theoretically in a microscopic model. The $\\pbar U$ optical potentials are obtained by folding free space $\\pbar N$ scattering amplitudes with HFB ground state densities and solving the scattering equations by direct integration. The mass dependence of absorption c...

  13. Proceedings of the Antiproton Technology Workshop Held in Upton, New York on 10 May 1989

    Science.gov (United States)

    1989-05-01

    Edwards Air Force Base, California 93523-5000 mm~mmmmmmmml mmIl.• ml l iJ m NOTICE When U.S. Government drawings, specifications, or other data are...before at these meetings, ASTER, named after the wildflower . Since I am limited to about ten minutes, I will keep my talk simple. Here is the outline...CALLAS JET PROPULSION LABORATORY CALIFORNIA INSTITUTE OF TECHNOLOGY PASADENA, CA PRESENTED AT THE ANTIPROTON TECHNOLOGY WORKSHOP HELD AT BROOKHAVEN

  14. Slope analysis for elastic proton-proton and proton-antiproton scattering

    OpenAIRE

    Okorokov, V. A.

    2008-01-01

    The diffraction slope parameter is investigated for elastic proton-proton and proton-antiproton scattering based on the all available experimental data at intermediate square of momentum transfer in the main. Energy dependence of the elastic diffraction slope is approximated by various analytic functions in a model-independent fashion. The expanded standard logarithmic approximations allow to describe experimental slopes in all available energy range at qualitative level reasonably. Various f...

  15. Malignant peripheral nerve sheath tumour of penis.

    Science.gov (United States)

    Kaur, J; Madan, R; Singh, L; Sharma, D N; Julka, P K; Rath, G K; Roy, S

    2015-04-01

    Malignant peripheral nerve sheath tumour (MPNST) is a rare variety of soft tissue sarcoma that originates from Schwann cells or pluripotent cells of neural crest origin. They have historically been difficult tumours to diagnose and treat. Surgery is the mainstay of treatment with a goal to achieve negative margins. Despite aggressive surgery and adjuvant therapy, the prognosis of patients with MPNST remains poor. MPNST arising from penis is a very rare entity; thus, it presents a diagnostic and therapeutic challenge. We present a case of penile MPNST in a 38-year-old man in the absence of neurofibromatosis treated with surgery followed by post-operative radiotherapy to a dose of 60 Gray in 30 fractions and adjuvant chemotherapy with ifosfamide and adriamycin.

  16. Bayesian analysis of spatial-dependent cosmic-ray propagation: Astrophysical background of antiprotons and positrons

    Science.gov (United States)

    Feng, Jie; Tomassetti, Nicola; Oliva, Alberto

    2016-12-01

    The AMS-02 experiment has reported a new measurement of the antiproton/proton ratio in Galactic cosmic rays (CRs). In the energy range E ˜60 - 450 GeV , this ratio is found to be remarkably constant. Using recent data on CR proton, helium, and carbon fluxes, 10Be/9Be and B/C ratios, we have performed a global Bayesian analysis based on a Markov chain Monte Carlo sampling algorithm under a "two halo model" of CR propagation. In this model, CRs are allowed to experience a different type of diffusion when they propagate in the region close to the Galactic disk. We found that the vertical extent of this region is about 900 pc above and below the disk, and the corresponding diffusion coefficient scales with energy as D ∝E0.15 , describing well the observations on primary CR spectra, secondary/primary ratios, and anisotropy. Under this model, we have carried out improved calculations of antiparticle spectra arising from secondary CR production and their corresponding uncertainties. We made use of Monte Carlo generators and accelerator data to assess the antiproton production cross sections and their uncertainties. While the positron excess requires the contribution of additional unknown sources, we found that the new AMS-02 antiproton data are consistent, within the estimated uncertainties, with our calculations based on secondary production.

  17. Measurements of Wake-Riding Electrons in Antiproton-Carbon-Foil Collisions

    CERN Multimedia

    2002-01-01

    When a charged particle passes through dielectric media, e.g. a thin carbon foil, a ``wake'' is induced. The characteristic wake-potential shows an oscillatory behaviour, with a wavelength of about $ 2 \\pi v _{p} / \\omega _{p} _{l} $ where $ v _{p} $ is the projectile velocity and $ \\omega _{p} _{l} $ the plasmon energy of the target. This induced wake potential is superimposed on the Coulomb potential of the projectile, the latter leading to a pronounced ``cusp'' of electrons leaving the solid at $ v _{e} app v _{p} $ for positively charged projectiles in the MeV region. Correspondingly, an ``anti-cusp'' is expected for antiprotons. \\\\ \\\\ In the solid, the wake-potential leads to an attractive force on electrons, and a dynamic electronic state is predicted both for proton and antiproton projectiles. In the solid, the wake-riding electrons are travelling with the projectile speed $ v _{p} $ Upon exit of the foil, the electron released from the wake-riding state of an antiproton will suddenly find itself in th...

  18. Limits on the Dark Matter from AMS-02 antiproton and positron fraction data

    CERN Document Server

    Lu, Bo-Qiang; Zong, Hong-Shi

    2015-01-01

    We derive limits on the dark matter annihilation cross section and lifetime using measurements of the AMS-02 antiproton ratio and positron fraction data. In deriving the limits, we consider the scenario of secondary particles accelerated in supernova remnants (SNRs) which has been argued to be able to reasonably account for the AMS-02 high energy positron/antiproton fraction data. We parameterize the contribution of secondary particles accelerated in SNRs and then fit the observational data within the conventional cosmic ray propagation model by adopting the GALPROP code. We use the likelihood ratio test to determine the 95$\\%$ confidence level upper limits of the possible dark matter (DM) contribution to the antiproton/positron fractions measured by AMS-02. Our limits are stronger than that set by the Fermi-LAT gamma-ray Pass 8 data of the dwarf spheroidal satellite galaxies. We also show that the solar modulation (cosmic ray propagation) parameters can play a non-negligible role in modifying the constraints...

  19. Antiproton-to-Proton Ratios for ALICE Heavy-Ion Collisions

    CERN Document Server

    Tawfik, A

    2010-01-01

    Assuming that the final state of hadronization takes place along the freezeout line, which is defined by a constant entropy density, the antiproton-to-proton ratios produced in heavy-ion collisions are studied in framework of the hadron resonance gas (HRG) model. A phase transition from quark--gluon plasma to hadrons, a hadronization, has been conjectured in order to allow modifications in the phase space volume and thus in single--particle distribution function. Implementing both modifications in the grand--canonical partition function and taking into account the experimental acceptance in heavy-ion collisions, the antiproton-to-proton ratios over center-of-mass energies $\\sqrt{s}$ ranging from AGS to RHIC are very well reproduced by the HRG model. Comparing with the same particle ratios in $pp$ collisions results in a gradually narrowing discrepancy with increasing $\\sqrt{s}$. At LHC energy, the ALICE antiproton-to-proton ratios in $pp$ collisions turn to be very well described by HRG model as well. It is l...

  20. Radiotherapy and skin tumors; Radiotherapie et tumeurs curanees

    Energy Technology Data Exchange (ETDEWEB)

    Calitchi, E.; KIrova, Y.; Le bourgeois, J.P. [Hopital Henri-Mondor, 94 - Creteil (France)

    1998-09-01

    Radiotherapy plays an important role in treatment of skin tumours. For skin carcinomas, external irradiation (kilo-voltage X-rays or electrons according to clinical characteristics) is more valuable than interstitial brachytherapy, which is recommended for tumours of the lip and of the nasal vestibule. In mycosis fungoides, total cutaneous electron beam radiation therapy is efficient for patients with limited superficial plaques. In the classical form of Kaposi`s sarcoma, radiotherapy can achieve local control-whereas it obtains good palliative results in the epidemic form. (author)

  1. Technological advances in radiotherapy for esophageal cancer

    Institute of Scientific and Technical Information of China (English)

    Milan; Vosmik; Jiri; Petera; Igor; Sirak; Miroslav; Hodek; Petr; Paluska; Jiri; Dolezal; Marcela; Kopacova

    2010-01-01

    Radiotherapy with concurrent chemotherapy and surgery represent the main treatment modalities in esophageal cancer.The goal of modern radiotherapy approaches,based on recent technological advances,is to minimize post-treatment complications by improving the gross tumor volume definition (positron emission tomography-based planning),reducing interfraction motion (image-guided radiotherapy) and intrafraction motion (respiratory-gated radiotherapy),and by better dose delivery to the precisely defined planning ...

  2. [Peripheral ulcerative keratitis].

    Science.gov (United States)

    Stamate, Alina-cristina; Avram, Corina Ioana; Malciolu, R; Oprea, S; Zemba, M

    2014-01-01

    Ulcerative keratitis is frequently associated with collagen vascular diseases and presents a predilection for peripheral corneal localization, due to the distinct morphologic and immunologic features of the limbal conjunctiva, which provides access for the circulating immune complexes to the peripheral cornea via the capillary network. Deposition of immune complexes in the terminal ends of limbal vessels initiates an immune-mediated vasculitis process, with inflammatory cells and mediators involvement by alteration of the vascular permeability. Peripheral ulcerative keratitis generally correlates with exacerbations of the background autoimmune systemic disease. Associated sceritis, specially the necrotizing form, is usually observed in severe cases, which may evolve in corneal perforation and loss of vision. Although the first-line of treatment in acute phases is represented by systemic administration of corticosteroids, immunosuppressive and cytotoxic agents are necessary for the treatment of peripheral ulcerative keratitis associated with systemic diseases.

  3. Treatment planning system for carbon ion radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Koyama-Ito, Hiroko [National Inst. of Radiological Sciences, Chiba (Japan)

    2002-06-01

    This paper describes the treatment planning (TP) and its peripheral system for carbon ion therapy that has been developed and in clinical use in recent two years at our institution. A new treatment planning system which is FOCUS customized to our irradiation system will be launched in clinical use soon. A new DICOM based PACS has been developed and in use. Now MRI, PET images are ready to be utilized for patient definition with image fusion functionality of radiotherapy TP. We implemented the exchange functionality of TP data specified by RTOG 3D QA Center in FOCUS, Pinnacle3 and heavy ion TP. Target volume and normal structure contours and dose distributions are exchangeable. A database system of carbon ion therapy dedicated to analysis of therapy data has been designed and implemented. All accessible planning data and treatment records of more than 1000 patients treated for seven and half years have been archived. The system has a DICOM RT sever and a database for miscellaneous text data. Limited numbers of private attributes were introduced for ion therapy specific objects. On-line as well as manual registration along with edit functionalities is prepared. Standard web browser is used to search and retrieve information. A DICOM RT viewer has been developed to view and retrieve RT images, dose distributions and structure set. These system described above are all designed to conform to the up-to-date standards of radiation therapy so as to be bases of the future development of the therapy at our institution. (author)

  4. Electrodiagnosis of peripheral neuropathy.

    Science.gov (United States)

    Ross, Mark A

    2012-05-01

    Electrodiagnostic studies are an important component of the evaluation of patients with suspected peripheral nerve disorders. The pattern of findings and the features that are seen on the motor and sensory nerve conduction studies and needle electromyography can help to identify the type of neuropathy, define the underlying pathophysiology (axonal or demyelinating), and ultimately help to narrow the list of possible causes. This article reviews the electrodiagnostic approach to and interpretation of findings in patients with peripheral neuropathies.

  5. Mutant frequency of radiotherapy technicians appears to be associated with recent dose of ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Messing, K.; Ferraris, J.; Bradley, W.E.; Swartz, J.; Seifert, A.M. (Universite du Quebec a Montreal (Canada))

    1989-10-01

    The frequency of hypoxanthine phosphoribosyl transferase (HPRT) mutants among peripheral T-lymphocytes of radiotherapy technicians primarily exposed to 60Co was measured by the T-cell cloning method. Mutant frequencies of these technicians in 1984 and 1986 were significantly higher than those of physiotherapy technicians who worked in a neighboring service, and correlated significantly with thermoluminescence dosimeter readings recorded during the 6 mo preceding mutant frequency determination. Correlations decreased when related to dose recorded over longer time intervals. HPRT mutant frequency determination in peripheral lymphocytes is a good measure of recently received biologically effective radiation dose in an occupationally exposed population.

  6. Antiproton production in Au + Au collisions at 11.7 A{center_dot}GeV/c

    Energy Technology Data Exchange (ETDEWEB)

    Sako, Hiroyuki [Tokyo Univ. (Japan)

    1997-02-01

    We investigated the dependence of antiproton yields on the number of wounded projectile nucleons (N{sub proj}). The dN/dy/N{sub proj} of antiprotons with the beam energy correction is almost constant from p+A to Si+A collisions, while it decreases in Au+Au collisions to 30-60% of the constant. Next, we have compared dependence of ratios of dN/dy, p-bar/{pi}{sup -}, p/{pi}{sup -}, K{sup -}/{pi}{sup -}, K{sup +}/{pi}{sup -}, and {pi}{sup +}/{pi}{sup -} at 1.2antiprotons in Au+Au collisions is much stronger than in p+A and Si+A collisions. We have compared the antiproton data with the RQMD model. In RQMD, antiprotons are produced initially from multi-step excitation processes and some of them are absorbed by nucleons with free NN-bar annihilation cross sections. RQMD reproduces overall tendencies of antiproton yields from p+A to Au+Au collisions within 50%. Finally, we explored the relation between baryon densities and antiproton yields in A+A collisions. We used a model in a static participant volume with the RQMD initial production and the absorption length with the free NN-bar annihilation cross section. In the model, only the antiprotons produced around the surface of the participant volume can survive. The model reproduces the scaling of experimental antiproton yields with the 2/3 power of the number of participants. By comparing the model with the experimental data, it is found that the ratio of the mean baryon density to the surface baryon density is 3-4 independent of collision systems. (J.P.N.). 109 refs.

  7. Thalassaemic osteoarthropathy treated with radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Davies, A.N. (King' s Coll. Hospital, London (United Kingdom))

    1993-11-01

    Patients with beta thalassaemia may develop a specific osteoarthropathy involving the feet. A number of different treatments for this condition have been tried, including rest, analgesia and hypertransfusion. We report a case of a patient with thalassaemic osteoarthropathy who responded to radiotherapy after failing conventional treatment. (author).

  8. Antiproton Production in 11.5A GeV/c Au+Pb Nucleus-Nucleus Collisions

    Energy Technology Data Exchange (ETDEWEB)

    De Cataldo, G.; Giglietto, N.; Raino, A.; Spinelli, P. [University of Bari/INFN, Bari (Italy); Dover, C.B. [Brookhaven National Laboratory, Upton, New York 11973 (United States); Huang, H.Z. [University of California at Los Angeles, Los Angeles, California 90024 (United States); Hill, J.C.; Libby, B.; Wohn, F.K. [Iowa State University, Ames, Iowa 50011 (United States); Rabin, M.S. [University of Massachusetts, Amherst, Massachusetts 01003 (United States); Haridas, P.; Pless, I.A.; Van Buren, G. [Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States); Armstrong, T.A.; Lewis, R.A.; Reid, J.D.; Smith, G.A.; Toothacker, W.S. [Pennsylvania State University, University Park, Pennsylvania 16802 (United States); Davies, R.; Hirsch, A.S.; Porile, N.T.; Rimai, A.; Scharenberg, R.P.; Srivastava, B.K.; Tincknell, M.L. [Purdue University, West Lafayette, Indiana 47907 (United States); Greene, S.V. [Vanderbilt University, Nashville, Tennessee 37235 (United States); Bennett, S.J.; Cormier, T.M.; Dee, P.; Fachini, P.; Kim, B.; Li, Q.; Li, Y.; Munhoz, M.G.; Pruneau, C.A.; Wilson, W.K.; Zhao, K. [Wayne State University, Detroit, Michigan 48201 (United States); Barish, K.N.; Bennett, M.J.; Chikanian, A.; Coe, S.D.; Diebold, G.E.; Finch, L.E.; George, N.K.; Kumar, B.S.; Lajoie, J.G.; Majka, R.D.; Nagle, J.L.; Pope, J.K.; Rotondo, F.S.; Sandweiss, J.; Slaughter, A.J.; Wolin, E.J. [Yale University, New Haven, Connecticut 06520 (United States)

    1997-11-01

    We present the first results from the E864 Collaboration on the production of antiprotons in 10{percent} central 11.5A GeV /c Au+Pb nucleus collisions at the Brookhaven Alternating Gradient Synchrotron. We report invariant multiplicities for antiproton production in the kinematic region 1.4{lt}y{lt}2.2 and 50{lt} p{sub T}{lt} 300 MeV/c , and compare our data with a first collision scaling model and previously published results from the E878 Collaboration. The differences between the E864 and E878 antiproton measurements and the implications for antihyperon production are discussed. {copyright} {ital 1997} {ital The American Physical Society}

  9. What Does The PAMELA Antiproton Spectrum Tell Us About Dark Matter?

    Energy Technology Data Exchange (ETDEWEB)

    Hooper, Dan [Chicago U., Astron. Astrophys. Ctr.; Linden, Tim [Chicago U., KICP; Mertsch, Philipp [KIPAC, Menlo Park

    2015-03-11

    Measurements of the cosmic ray antiproton spectrum can be used to search for contributions from annihilating dark matter and to constrain the dark matter annihilation cross section. Depending on the assumptions made regarding cosmic ray propagation in the Galaxy, such constraints can be quite stringent. We revisit this topic, utilizing a set of propagation models fit to the cosmic ray boron, carbon, oxygen and beryllium data. We derive upper limits on the dark matter annihilation cross section and find that when the cosmic ray propagation parameters are treated as nuisance parameters (as we argue is appropriate), the resulting limits are significantly less stringent than have been previously reported. We also note (as have several previous groups) that simple GALPROP-like diffusion-reacceleration models predict a spectrum of cosmic ray antiprotons that is in good agreement with PAMELA's observations above ~ 5 GeV, but that significantly underpredict the flux at lower energies. Although the complexity of modeling cosmic ray propagation at GeV-scale energies makes it difficult to determine the origin of this discrepancy, we consider the possibility that the excess antiprotons are the result of annihilating dark matter. Suggestively, we find that this excess is best fit for mDM ~ 35 GeV and σ v ~ 10$-$26 cm3/s (to $b\\bar{_b}$), in good agreement with the mass and cross section previously shown to be required to generate the gamma-ray excess observed from the Galactic Center.

  10. High-precision comparison of the antiproton-to-proton charge-to-mass ratio

    Science.gov (United States)

    Ulmer, S.; Smorra, C.; Mooser, A.; Franke, K.; Nagahama, H.; Schneider, G.; Higuchi, T.; van Gorp, S.; Blaum, K.; Matsuda, Y.; Quint, W.; Walz, J.; Yamazaki, Y.

    2015-08-01

    Invariance under the charge, parity, time-reversal (CPT) transformation is one of the fundamental symmetries of the standard model of particle physics. This CPT invariance implies that the fundamental properties of antiparticles and their matter-conjugates are identical, apart from signs. There is a deep link between CPT invariance and Lorentz symmetry--that is, the laws of nature seem to be invariant under the symmetry transformation of spacetime--although it is model dependent. A number of high-precision CPT and Lorentz invariance tests--using a co-magnetometer, a torsion pendulum and a maser, among others--have been performed, but only a few direct high-precision CPT tests that compare the fundamental properties of matter and antimatter are available. Here we report high-precision cyclotron frequency comparisons of a single antiproton and a negatively charged hydrogen ion (H-) carried out in a Penning trap system. From 13,000 frequency measurements we compare the charge-to-mass ratio for the antiproton to that for the proton and obtain . The measurements were performed at cyclotron frequencies of 29.6 megahertz, so our result shows that the CPT theorem holds at the atto-electronvolt scale. Our precision of 69 parts per trillion exceeds the energy resolution of previous antiproton-to-proton mass comparisons as well as the respective figure of merit of the standard model extension by a factor of four. In addition, we give a limit on sidereal variations in the measured ratio of <720 parts per trillion. By following the arguments of ref. 11, our result can be interpreted as a stringent test of the weak equivalence principle of general relativity using baryonic antimatter, and it sets a new limit on the gravitational anomaly parameter of < 8.7 × 10-7.

  11. Rapidity distributions of antiprotons in Si+A and Au+A collisions

    Energy Technology Data Exchange (ETDEWEB)

    Shiva Kumar, B. [Yale Univ., New Haven, CT (United States); Beavis, D.; Bennett, M.; Carroll, J.B.; Chiba, J.; Crawford, H.J.; Debbe, R.; Doke, T.; Engelage, J.; Greiner, L.; Hayano, R.S.; Hallman, T.J.; Heckman, H.H.; Kashiwagi, T.; Kikuchi, J.; Kuo, C.; Lindstrom, P.J.; Mitchell, J.W.; Nagamiya, S.; Pope, K.; Stankus, P.; Tanaka, K.H.; Welsh, R.C.; Zhan, W.; E858/E878 Collaboration

    1994-01-03

    We have studied the production of {pi}{sup {+-}}, K{sup {+-}}, p, anti p, and light nuclei in relativistic Si+nucleus and Au+nucleus collisions using a zero degree focusing spectrometer. We find that for the antiprotons, the width of the rapidity distribution measured at p{sub t}=0 increases in going from Si+Al collisions to Au+Au collisions in spite of the lower center of mass energy of the latter measurement. We discuss our data, and the implications of our measurement. We also report sensitivity limits on the production of exotic particles. (orig.)

  12. Antiproton--proton annihilation into pion pairs within effective meson theory

    CERN Document Server

    Wang, Ying; Tomasi-Gustafsson, Egle

    2015-01-01

    Antiproton--proton annihilation into light mesons is revisited in the few GeV energy domain, in view of a global description of the existing data. An effective meson model is developed, with mesonic and baryonic degrees od freedom in $s$, $t$, and $u$ channels. Regge factors are added to reproduce the proper energy behavior and the forward and backward peaked behavior. A comparison with existing data and predictions for angular distributions and energy dependence are done for charged and neutral pion pair production.

  13. Antiproton stopping at low energies: confirmation of velocity-proportional stopping power.

    Science.gov (United States)

    Møller, S P; Csete, A; Ichioka, T; Knudsen, H; Uggerhøj, U I; Andersen, H H

    2002-05-13

    The stopping power for antiprotons in various solid targets has been measured in the low-energy range of 1-100 keV. In agreement with most models, in particular free-electron gas models, the stopping power is found to be proportional to the projectile velocity below the stopping-power maximum. Although a stopping power proportional to velocity has also been observed for protons, the interpretation of such measurements is difficult due to the presence of charge exchange processes. Hence, the present measurements constitute the first unambiguous support for a velocity-proportional stopping power due to target excitations by a pointlike projectile.

  14. Measurement of (anti)deuteron and (anti)proton production in DIS at HERA

    CERN Document Server

    Chekanov, S; Magill, S; Musgrave, B; Nicholass, D; Repond, J; Yoshida, R; Mattingly, M C K; Jechow, M; Pavel, N; Yagues-Molina, A G; Antonelli, S; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Bindi, M; Boscherini, D; Bruni, A; Bruni, G; Cifarelli, L; Cindolo, F; Contin, A; Corradi, M; De Pasquale, S; Iacobucci, G; Margotti, A; Nania, R; Polini, A; Sartorelli, G; Zichichi, A; Bartsch, D; Brock, I; Goers, S; Hartmann, H; Hilger, E; Jakob, H P; Jüngst, M; Kind, O M; Nuncio-Quiroz, A E; Paul, E; Renner, R; Samson, U; Schonberg, V; Shehzadi, R; Wlasenko, M; Brook, N H; Heath, G P; Morris, J D; Namsoo, T; Capua, M; Fazio, S; Mastroberardino, A; Schioppa, M; Susinno, G; Tassi, E; Kim, J Y; Ma, K J; Ibrahim, Z A; Kamaluddin, B; Wan-Abdullah, W A T; Ning, Y; Ren, Z; Sciulli, F; Chwastowski, J; Eskreys, A; Figiel, J; Galas, A; Gil, M; Olkiewicz, K; Stopa, P; Zawiejski, L; Adamczyk, L; Bold, T; Grabowska-Bold, I; Kisielewska, D; Lukasik, J; Przybycien, M; Suszycki, L; Kotanski, A; Slominski, W; Adler, V; Behrens, U; Bloch, I; Blohm, C; Bonato, A; Borras, K; Ciesielski, R; Coppola, N; Dossanov, A; Drugakov, V; Fourletova, J; Geiser, A; Gladkov, D; Göttlicher, P; Grebenyuk, J; Gregor, I; Haas, T; Hain, W; Horn, C; Huttmann, A; Kahle, B; Katkov, I I; Klein, U; Kötz, U; Kowalski, H; Lobodzinska, E; Löhr, B; Mankel, R; Melzer-Pellmann, I A; Miglioranzi, S; Montanari, A; Notz, D; Rinaldi, L; Roloff, P; Rubinsky, I; Santamarta, R; Schneekloth, U; Spiridonov, A; Stadie, H; Szuba, D; Szuba, J; Theedt, T; Wolf, G; Wrona, K; Youngman, C; Zeuner, W; Lohmann, W; Schlenstedt, S; Barbagli, G; Gallo, E; Pelfer, P G; Bamberger, A; Dobur, D; Karstens, F; Vlasov, N N; Bussey, P J; Doyle, A T; Dunne, W; Ferrando, J; Forrest, M; Saxon, D H; Skillicorn, I O; Gialas, I; Papageorgiu, K; Gosau, T; Holm, U; Klanner, R; Lohrmann, E; Salehi, H; Schleper, P; Schörner-Sadenius, T; Sztuk, J; Wichmann, K; Wick, K; Foudas, C; Fry, C; Long, K R; Tapper, A D; Kataoka, M; Matsumoto, T; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Barakbaev, A N; Boos, E G; Pokrovskiy, N S; Zhautykov, B O; Aushev, V; Son, D; De Favereau, J; Piotrzkowski, K; Barreiro, F; Glasman, C; Jiménez, M; Labarga, L; Del Peso, J; Ron, E; Soares, M; Terron, J; Zambrana, M; Corriveau, F; Liu, C; Walsh, R; Zhou, C; Tsurugai, T; Antonov, A; Dolgoshein, B A; Sosnovtsev, V; Stifutkin, A; Suchkov, S; Dementiev, R K; Ermolov, P F; Gladilin, L K; Khein, L A; Korzhavina, I A; Kuzmin, V A; Levchenko, B B; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Zotkin, D S; Zotkin, S A; Abt, I; Büttner, C; Caldwell, A; Kollar, D; Schmidke, W B; Sutiak, J; Grigorescu, G; Keramidas, A; Koffeman, E; Kooijman, P; Pellegrino, A; Tiecke, H; Vázquez, M; Wiggers, L; Brümmer, N; Bylsma, B; Durkin, L S; Lee, A; Ling, T Y; Allfrey, P D; Bell, M A; Cooper-Sarkar, A M; Cottrell, A; Devenish, R C E; Foster, B; Korcsak-Gorzo, K; Patel, S; Roberfroid, V; Robertson, A; Straub, P B; Uribe-, C; Estrada; Walczak, R; Bellan, P; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dusini, S; Garfagnini, A; Limentani, S; Longhin, A; Stanco, L; Turcato, M; Oh, B Y; Raval, A; Ukleja, J; Whitmore, J J; Iga, Y; D'Agostini, G; Marini, G; Nigro, A; Cole, J E; Hart, J C; Abramowicz, H; Gabareen, A; Ingbir, R; Kananov, S; Levy, A; Kuze, M; Maeda, J; Hori, R; Kagawa, S; Okazaki, N; Shimizu, S; Tawara, T; Hamatsu, R; Kaji, H; Kitamura, S; Ota, O; Ri, Y D; Ferrero, M I; Monaco, V; Sacchi, R; Solano, A; Arneodo, M; Ruspa, M; Fourletov, S; Martin, J F; Boutle, S K; Butterworth, J M; Gwenlan, C; Jones, T W; Loizides, J H; Sutton, M R; Wing, M; Brzozowska, B; Ciborowski, J; Grzelak, G; Kulinski, P; Luzniak, P; Malka, J; Nowak, R J; Pawlak, J M; Tymieniecka, T; Ukleja, A; Zarnecki, A F; Adamus, M; Plucinsky, P P; Eisenberg, Y; Giller, I; Hochman, D; Karshon, U; Rosin, M; Brownson, E; Danielson, T; Everett, A; Kcira, D; Reeder, D D; Ryan, P; Savin, A A; Smith, W H; Wolfe, H; Bhadra, S; Catterall, C D; Cui, Y; Hartner, G; Menary, S; Noor, U; Standage, J; Whyte, J

    2007-01-01

    The first observation of (anti)deuterons in deep inelastic scattering at HERA has been made with the ZEUS detector at a centre-of-mass energy of 300--318 GeV using an integrated luminosity of 120 pb-1. The measurement was performed in the central rapidity region for transverse momentum per unit of mass in the range 0.3anti)proton yield by approximately three orders of magnitude, consistent with the world measurements.

  15. The FLUKA study of the secondary particles fluence in the AD-Antiproton Decelerator target area

    CERN Document Server

    Calviani, M

    2014-01-01

    In this paper we present Monte Carlo FLUKA simulations [1, 2] carried out to investigate the secondary particles fluence emerging from the antiproton production target and their spatial distribution in the AD target area. The detailed quantitative analysis has been performed for different positions along the magnet dog-leg as well as after the main collimator. These results allow tuning the position of the new beam current transformers (BCT) in the target area, in order to have a precise pulse-by-pulse evaluation of the intensity of negative particles injected in the AD-ring before the deceleration phase.

  16. Colliding beam physics at Fermilab: interaction regions, beam storage, antiproton cooling, production, and colliding

    Energy Technology Data Exchange (ETDEWEB)

    Walker, J.K. (ed.)

    1977-01-01

    The purpose of the colliding beams experment department at Fermilab was to bring about collisions of the stored beams in the energy doubler/saver and main ring, and construct experimental areas with appropriate detectors. To explore the feasibility of using the main ring as a storage device, several studies were carried out to investigate beam growth, loss, and the backgrounds in detectors at possible intersection regions. This range of developments constituted the major topics at the 1977 Summer Study reported here. Emphasis in part one is on interaction regions, beam storage, antiproton cooling, production, and colliding. 40 papers from this part are included in the data base. (GHT)

  17. Highlights on gamma rays, neutrinos and antiprotons from TeV Dark Matter

    Directory of Open Access Journals (Sweden)

    Gammaldi Viviana

    2016-01-01

    Full Text Available It has been shown that the gamma-ray flux observed by HESS from the J1745-290 Galactic Center source is well fitted as the secondary gamma-rays photons generated from Dark Matter annihilating into Standard Model particles in combination with a simple power law background. The neutrino flux expected from such Dark Matter source has been also analyzed. The main results of such analyses for 50 TeV Dark Matter annihilating into W+W− gauge boson and preliminary results for antiprotons are presented.

  18. Study of antiproton annihilation on neutrons into $\\omega\\pi^{-} \\pi^{0}$

    CERN Document Server

    Amsler, Claude; Baker, C A; Barnett, B M; Batty, C J; Benayoun, M; Blüm, P; Braune, K; Case, A; Credé, V; Crowe, K M; Doser, Michael; Dünnweber, W; Engelhardt, D; Faessler, M A; Haddock, R P; Heinsius, F H; Hessey, N P; Hidas, P; Jamnik, D; Kalinowsky, H; Kammel, P; Kisiel, J; Klempt, E; Koch, H; Kunze, M; Kurilla, U; Landua, Rolf; Matthäy, H; Meyer, C A; Meyer-Wildhagen, F; Ouared, R; Peters, K; Pick, B; Ratajczak, M; Regenfus, C; Reinnarth, J; Sarantsev, A V; Strohbusch, U; Suffert, Martin; Suh, J S; Thoma, U; Uman, I; Wallis-Plachner, S; Walther, D; Wiedner, U; Wittmack, K

    2004-01-01

    Data are presented on antiproton neutron annihilation at rest into omega pi /sup -/ pi /sup 0/ taken with the Crystal Barrel detector at LEAR (CERN) using a liquid deuterium target. The partial wave analysis shows evidence for at least two omega pi vector resonances above the rho (770) ground-state. Possible evidence for a third rho ' state with a mass around 1180 MeV is discussed. The results are compared to model dependent predictions concerning the nature of the rho ' states. (35 refs).

  19. Search For Magnetic Monopoles Possibly Produced By Proton-antiproton Collisions At The Tevatron Collider

    CERN Document Server

    Luo, W

    2002-01-01

    Magnetic monopoles can be used to explain the quantization of electric charge, and are predicted by gauge field theory. If monopoles exist, they could have been produced by the proton-antiproton collisions at the Tevatron collider—the highest energy accelerator existing in the world, and trapped in the CDF and DØ detectors. We took Al, Be, and Pb samples from the Tevatron and used the induction technique with SQUIDs (Superconducting Quantum Interference Devices) to detect monopoles in the samples. We did not find monopoles, but we have set new limits for the monopole mass and the relavant cross section based on a Drell-Yan model and Monte Carlo calculation.

  20. [Peripheral facial nerve palsy].

    Science.gov (United States)

    Pons, Y; Ukkola-Pons, E; Ballivet de Régloix, S; Champagne, C; Raynal, M; Lepage, P; Kossowski, M

    2013-06-01

    Facial palsy can be defined as a decrease in function of the facial nerve, the primary motor nerve of the facial muscles. When the facial palsy is peripheral, it affects both the superior and inferior areas of the face as opposed to central palsies, which affect only the inferior portion. The main cause of peripheral facial palsies is Bell's palsy, which remains a diagnosis of exclusion. The prognosis is good in most cases. In cases with significant cosmetic sequelae, a variety of surgical procedures are available (such as hypoglossal-facial anastomosis, temporalis myoplasty and Tenzel external canthopexy) to rehabilitate facial aesthetics and function.

  1. Study of malignant peripheral nerve sheath tumor in cerebellopontine angle.

    Science.gov (United States)

    Hong, WenMing; Cheng, HongWei; Wang, XiaoJie; Hu, XiaoPeng; Feng, ChunGuo

    2014-01-01

    Malignant peripheral nerve sheath tumors (MPNSTs) are very rare soft tissue sarcomas, usually arising from somatic soft tissues or peripheral nerves. Primary MPNST of the cerebellopontine angle is extremely rare, with only a single case reported so far. Here, we report an unusual case of MPNST in cerebellopontine angle in a 25-year-old man presented with dizziness, left facial numbness, and tinnitus. After hospitalization, the tumor was treated with complete surgical excision followed by adjuvant chemotherapy and radiotherapy. Histologically, the tumor showed malignant spindle cells, which were with focal S-100 positivity on immunohistochemistry, and a diagnosis of the MPNST was made. This case is being reported for its rarity and presence in cerebellopontine and illustrated the difficulties in the diagnosis and treatment of MPNST, which to the best of our knowledge, has not been described before in the soft tissue sarcomas.

  2. [A peripheral osteoma].

    NARCIS (Netherlands)

    Mizbah, K.; Soehardi, A.; Maal, T.J.J.; Weijs, W.L.J.; Merkx, M.A.W.; Barkhuysen, R.

    2012-01-01

    A 43-year-old man appeared with a painless, asymptomatic swelling on the left side of his neck, which had existed for years and had slowly been progressing. After surgical removal, it became clear that it had to do with a peripheral osteoma. This is a benign lesion with a low incidence. Generally, c

  3. Backgrounded but not peripheral

    DEFF Research Database (Denmark)

    Hovmark, Henrik

    2013-01-01

    -cultural construction of identity, and, as a matter of fact, that their role might be quite important. I argue that the DDAs are backgrounded but not peripheral, i.e. marginal or insignificant. And I introduce the notion of “contextualization cue” in this argument (Levinson, 2003a, Gumperz, 1992)....

  4. Proton Radiotherapy for Pediatric Sarcoma

    Energy Technology Data Exchange (ETDEWEB)

    Ladra, Matthew M.; Yock, Torunn I., E-mail: tyock@partners.org [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114 (United States)

    2014-01-14

    Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by eliminating excess dose deposited beyond the target volume, thereby reducing both the dose of radiation delivered to non-target structures as well as the total radiation dose delivered to a patient. Dosimetric studies comparing proton plans to IMRT and 3D conformal radiation have demonstrated the superiority of protons in numerous pediatric malignancies and data on long-term clinical outcomes and toxicity is emerging. In this article, we review the existing clinical and dosimetric data regarding the use of proton beam radiation in malignant bone and soft tissue sarcomas.

  5. The new large-scale international facility for antiproton and ion research in Europe, FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Rosner, Guenther [Facility for Antiprotons and Ion Research (FAIR), Darmstadt (Germany)

    2012-07-01

    Full text: FAIR is currently the largest project in nuclear and particle physics worldwide, with investment costs of 1.6B euro in its first phase. It has been founded by Finland, France, Germany, India, Poland, Romania, Russia, Slovenia and Sweden in Oct. 2010. The facility will provide the international scientific community with a unique and technically innovative particle accelerator system to perform cutting-edge research in the sciences concerned with the basic structure of matter in: nuclear and particle physics, atomic and anti-matter physics, high density plasma physics, and applications in condensed matter physics, biology and the bio-medical sciences. The work horse of FAIR will be a 1.1 km circumference double ring of rapidly cycling 100 and 300 Tm synchrotrons, which will be used to produce high intensity secondary beams of anti-protons and very short-lived radioactive ions. A subsequent suite of cooler and storage rings will deliver anti-proton and heavy-ion beams of unprecedented quality regarding intensity and resolution. Large experimental facilities are presently being prototyped by the APPA, CBM, NuSTAR and PANDA Collaborations to be used by a global community of more than 3000 scientists from 2018. (author)

  6. The CERN antiproton target: hydrocode analysis of its core material dynamic response under proton beam impact

    CERN Document Server

    Martin, Claudio Torregrosa; Calviani, Marco; Muñoz-Cobo, José-Luis

    2016-01-01

    Antiprotons are produced at CERN by colliding a 26 GeV/c proton beam with a fixed target made of a 3 mm diameter, 55 mm length iridium core. The inherent characteristics of antiproton production involve extremely high energy depositions inside the target when impacted by each primary proton beam, making it one of the most dynamically demanding among high energy solid targets in the world, with a rise temperature above 2000 {\\deg}C after each pulse impact and successive dynamic pressure waves of the order of GPa's. An optimized redesign of the current target is foreseen for the next 20 years of operation. As a first step in the design procedure, this numerical study delves into the fundamental phenomena present in the target material core under proton pulse impact and subsequent pressure wave propagation by the use of hydrocodes. Three major phenomena have been identified, (i) the dominance of a high frequency radial wave which produces destructive compressive-to-tensile pressure response (ii) The existence of...

  7. The proton injector for the accelerator facility of antiproton and ion research (FAIR)

    Energy Technology Data Exchange (ETDEWEB)

    Ullmann, C., E-mail: c.ullmann@gsi.de; Kester, O. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstr. 1, 64291 Darmstadt (Germany); Institut für Angewandte Physik, Goethe-Universität Frankfurt, Max-von-Laue-Str. 1, 60438 Frankfurt/Main (Germany); Berezov, R.; Fils, J.; Hollinger, R.; Vinzenz, W. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstr. 1, 64291 Darmstadt (Germany); Chauvin, N.; Delferriere, O. [Commissariat à l’Energie Atomique et aux Energies Alternatives, IRFU, F-91191-Gif-sur-Yvette (France)

    2014-02-15

    The new international accelerator facility for antiproton and ion research (FAIR) at GSI in Darmstadt, Germany, is one of the largest research projects worldwide and will provide an antiproton production rate of 7 × 10{sup 10} cooled pbars per hour. This is equivalent to a primary proton beam current of 2 × 10{sup 16} protons per hour. For this request a high intensity proton linac (p-linac) will be built with an operating rf-frequency of 325 MHz to accelerate a 35 mA proton beam at 70 MeV, using conducting crossed-bar H-cavities. The repetition rate is 4 Hz with beam pulse length of 36 μs. The microwave ion source and low energy beam transport developed within a joint French-German collaboration GSI/CEA-SACLAY will serve as an injector of the compact proton linac. The 2.45 GHz ion source allows high brightness ion beams at an energy of 95 keV and will deliver a proton beam current of 100 mA at the entrance of the radio frequency quadrupole (RFQ) within an acceptance of 0.3π mm mrad (norm., rms)

  8. Search for Resonances in the Photoproduction of Proton-Antiproton Pairs

    Energy Technology Data Exchange (ETDEWEB)

    Stokes, Burnham [Florida State Univ., Tallahassee, FL (United States)

    2006-01-01

    Results are reported on the reaction γp → p$\\bar{p}$p with beam energy in the range 4.8-5.5 GeV. The data were collected at the Thomas Jefferson National Accelerator Facility in CLAS experiment E01-017(G6C). The focus of this study is an understanding of the mechanisms of photoproduction of proton-antiproton pairs, and to search for intermediate resonances, both narrow and broad, which decay to p$\\bar{p}$. The total measured cross section in the photon energy range 4.8-5.5 GeV is σ = 33 ± 2 nb. Measurement of the cross section as a function of energy is provided. An upper limit on the production of a narrow resonance state previously observed with a mass of 2.02 GeV/c2 is placed at 0.35 nb. No intermediate resonance states were observed. Meson exchange production appears to dominate the production of the proton-antiproton pairs.

  9. Monte-Carlo simulation of events for (un)polarized Drell-Yan with antiprotons

    CERN Document Server

    Bianconi, A

    2004-01-01

    The complete knowledge of the nucleon spin structure at leading twist requires also addressing the transverse spin distribution of quarks, or transversity, which is yet unexplored because of its chiral-odd nature. Transversity can be best extracted from single-spin asymmetries in fully polarized Drell-Yan processes with antiprotons, where valence contributions are involved anyway. Alternatively, in single-polarized Drell-Yan the transversity happens convoluted with another chiral-odd function, which is likely to be responsible for the well known (and yet unexplained) violation of the Lam-Tung sum rule in the corresponding unpolarized cross section. We present Monte-Carlo simulations for the unpolarized and single-polarized Drell-Yan $\\bar{p} p^{(\\uparrow)} \\to \\mu^+ \\mu^- X$ with antiproton beam energies of 40 and 15 GeV as a test case, in order to estimate the minimum number of events needed to extract the above chiral-odd distributions from future measurements at the HESR ring at GSI. It is important to stu...

  10. X-rays from antiprotonic sup 3 He and sup 4 He

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, M.; Bacher, R.; Bluem, P.; Gotta, D.; Heitlinger, K.; Kunold, W.; Rohmann, D. (Kernforschungszentrum Karlsruhe GmbH (Germany, F.R.). Inst. fuer Kernphysik Karlsruhe Univ. (T.H.) (Germany, F.R.). Inst. fuer Experimentelle Kernphysik); Egger, J.; Simons, L.M. (Paul Scherrer Inst. (PSI), Villigen (Switzerland)); Elsener, K. (European Organization for Nuclear Research, Geneva (Switzerland))

    1991-02-01

    Antiprotonic X-rays from the helium isotopes have been observed at pressures of 36, 72, 375 and 600 mbar. The antiproton beam from LEAR with momenta of 309 and 202 MeV/c has been stopped at these pressures using the cyclotron trap. The X-rays were detected with Si(Li) and intrinsic Ge semiconductor detectors. Absolute X-ray yields were determined and the strong-interaction 2p shifts and the 2p and 3d broadenings measured to be {epsilon}{sub 2p}=(-17{plus minus}4) eV, {Gamma}{sub 2p}=(25{plus minus}9) eV and {Gamma}{sub 3d}=(2.14{plus minus}0.18) meV for anti p{sup 3}He and {epsilon}{sub 2p}=(-18{plus minus}2) eV, {Gamma}{sub 2p}=(45{plus minus}5) eV and {Gamma}{sub 3d}=(2.36{plus minus}0.10) meV for anti p{sup 4}He. (orig.).

  11. GAPS - Dark matter search with low-energy cosmic-ray antideuterons and antiprotons

    CERN Document Server

    von Doetinchem, P; Boggs, S; Fuke, H; Hailey, C J; Mognet, S I; Ong, R A; Perez, K; Zweerink, J

    2015-01-01

    The GAPS experiment is foreseen to carry out a dark matter search by measuring low-energy cosmic-ray antideuterons and antiprotons with a novel detection approach. It will provide a new avenue to access a wide range of different dark matter models and masses from about 10GeV to 1TeV. The theoretically predicted antideuteron flux resulting from secondary interactions of primary cosmic rays is very low. Well-motivated theories beyond the Standard Model contain viable dark matter candidates, which could lead to a significant enhancement of the antideuteron flux due to annihilation or decay of dark matter particles. This flux contribution is believed to be especially large at low energies, which leads to a high discovery potential for GAPS. The GAPS low-energy antiproton search will provide some of the most stringent constraints on ~30GeV dark matter, will provide the best limits on primordial black hole evaporation on galactic length scales, and explore new discovery space in cosmic-ray physics. GAPS is designed...

  12. A possible dark matter annihilation signal in the AMS-02 antiproton data

    CERN Document Server

    Cui, Ming-Yang; Tsai, Yue-Lin Sming; Fan, Yi-Zhong

    2016-01-01

    A new approach has been adopted to probe the dark matter signal using the latest AMS-02 cosmic ray antiproton flux data. Different from previous studies, we do not assume specific propagation, injection, and solar modulation parameters when calculating the antiproton fluxes, but use the results inferred from the B/C ratio and proton data from the recent PAMELA/AMS-02 measurements instead. A joint likelihood method including the likelihood of these background parameters is established within the Bayesian framework. We find that a dark matter signal is favored with a high test statistic value of $\\sim 70$. The rest mass of the dark matter particles is $\\sim 30-70$ GeV and the velocity-averaged hadronic annihilation cross section is about $(1-6)\\times 10^{-26}$ cm$^{3}$s$^{-1}$, in agreement with that needed to account for the Galactic center GeV excess and/or the weak GeV emission from dwarf galaxies Reticulum 2 and Tucana III. Tight constraints on the dark matter annihilation models are also set in a wide mass...

  13. Measurement of the Antiproton-Proton Total Cross-Section at the CERN ISR

    CERN Multimedia

    2002-01-01

    This experiment is a measurement of small angle scattering of antiprotons on protons and of protons on protons at 15/15, 22/22, 26/26 and 31/31 GeV, with the aim of obtaining data on the total cross-section for the scattering of protons on protons, and of determining the ratio of the real to the imaginary scattering amplitude at zero momentum transfer for antiprotons on protons. The measurement is divided into two parts: \\item 1) The measurement of @s^t^o^t(@*p) and @s^t^o^t(pp), using hodoscopes placed at small angles, outside the vacuum pipe, at approximately 9 metres from the intersection point. \\item 2) The measurement of the region in !t!, the momentum transfer squared, around the value !t^c!, where Coulomb and nuclear scattering are equal, in order to deduce the quantity @r = Re f(t=0)/Im f(t=0). This latter measurement is done by employi in earlier @s^t(pp) and @r experiments at the ISR. \\end{enumerate} In both set-ups the measurements are made by recording coincidences between collinear counters in th...

  14. Meas.of the Ratio Between Double and Single Ionization of Helium for Antiprotons

    CERN Multimedia

    2002-01-01

    The aim of this experiment is to measure the ratio between double and single ionization of helium by antiprotons in the energy range $>$~3~MeV. Comparison with already existing proton data will yield information on the mechanisms for double ionization, which could not be extracted from previous comparisons between ratios measured for equivelocity electrons and protons. The most basic information to be obtained from an antiproton experiment will be the amount of correlation existing between the two electrons in the ground-state helium atom.\\\\ \\\\ The equipment consists of a gas cell, which employs slow-ion collection via the so-called condenser-plate method for the absolute sum of partial-ionization cross sections and determination of the relative contribution of multiple charged ions by TOF. The gas cell has movable entrance and exit slits and a grid system to account for secondary emission from the collection of slow ions. Together with a field of 800~V/cm in the collision region, the potentials of the TOF sp...

  15. Novel dark matter constraints from antiprotons in the light of AMS-02

    CERN Document Server

    Cuoco, Alessandro; Korsmeier, Michael

    2016-01-01

    We evaluate dark matter (DM) limits from cosmic-ray antiproton observations using the recent precise AMS-02 measurements. We properly take into account cosmic-ray propagation uncertainties fitting at the same time DM and propagation parameters, and marginalizing over the latter. We find a significant (~4.5 sigma) indication of a DM signal for DM masses near 80 GeV, with a hadronic annihilation cross-section close to the thermal value, sigma v ~3e-26 cm3s-1. Intriguingly, this signal is compatible with the DM interpretation of the Galactic center gamma-ray excess. Confirmation of the signal will require a more accurate study of the systematic uncertainties, i.e., the antiproton production cross-section, and modelling of the solar modulation effect. Interpreting the AMS-02 data in terms of upper limits on hadronic DM annihilation, we obtain strong constraints excluding a thermal annihilation cross-section for DM masses below about 50 GeV and in the range between approximately 150 and 500 GeV, even for conservat...

  16. Cryogenic Current Comparator as Low Intensity Beam Current Monitor in the CERN Antiproton Decelerators

    CERN Document Server

    Fernandes, M; Soby, L; Welsch, CP

    2013-01-01

    In the low-energy Antiproton Decelerator (AD) and the future Extra Low ENergy Antiproton (ELENA) rings at CERN, an absolute measurement of the beam intensity is essential to monitor any losses during the deceleration and cooling phases. However, existing DC current transformers can hardly reach the μA level, while at the AD and ELENA currents can be as low as 100 nA. A Cryogenic Current Comparator (CCC) based on a superconducting quantum interference device (SQUID) is currently being designed and shall be installed in the AD and ELENA machines. It should meet the following specifications: A current resolution smaller than 10 nA, a dynamic range covering currents between 100 nA and 1 mA, as well as a bandwidth from DC to 1 kHz. Different design options are being considered, including the use of low or high temperature superconductor materials, different CCC shapes and dimensions, different SQUID characteristics, as well as electromagnetic shielding requirements. In this contribution we present first results f...

  17. CERN antiproton target: Hydrocode analysis of its core material dynamic response under proton beam impact

    Science.gov (United States)

    Martin, Claudio Torregrosa; Perillo-Marcone, Antonio; Calviani, Marco; Muñoz-Cobo, José-Luis

    2016-07-01

    Antiprotons are produced at CERN by colliding a 26 GeV /c proton beam with a fixed target made of a 3 mm diameter, 55 mm length iridium core. The inherent characteristics of antiproton production involve extremely high energy depositions inside the target when impacted by each primary proton beam, making it one of the most dynamically demanding among high energy solid targets in the world, with a rise temperature above 2000 °C after each pulse impact and successive dynamic pressure waves of the order of GPa's. An optimized redesign of the current target is foreseen for the next 20 years of operation. As a first step in the design procedure, this numerical study delves into the fundamental phenomena present in the target material core under proton pulse impact and subsequent pressure wave propagation by the use of hydrocodes. Three major phenomena have been identified, (i) the dominance of a high frequency radial wave which produces destructive compressive-to-tensile pressure response (ii) The existence of end-of-pulse tensile waves and its relevance on the overall response (iii) A reduction of 44% in tensile pressure could be obtained by the use of a high density tantalum cladding.

  18. ${\\bar D}D$ meson pair production in antiproton-nucleus collisions

    CERN Document Server

    Shyam, R

    2016-01-01

    We study the $\\bar D D$ (${\\bar D}^0 D^0$ and $D^-D^+$) charm meson pair production in antiproton (${\\bar p}$) induced reactions on nuclei at beam energies ranging from threshold to several GeV. Our model is based on an effective Lagrangian approach that has only the baryon-meson degrees of freedom and involves the physical hadron masses. The reaction proceeds via the $t$-channel exchanges of $\\Lambda_c^+$, $\\Sigma_c^+$, and $\\Sigma_c^{++}$ baryons in the initial collision of the antiproton with one of the protons of the target nucleus. The medium effects on the exchanged baryons are included by incorporating in the corresponding propagators, the effective charm baryon masses calculated within a quark-meson coupling (QMC) model. The wave functions of the bound proton have been determined within the QMC model as well as in a phenomenological model where they are obtained by solving the Dirac equation with appropriate scalar and vector potentials. The initial- and final-state distortion effects have been approx...

  19. High precision spectroscopy of pionic and antiprotonic atoms; Spectroscopie de precision des atomes pioniques et antiprotoniques

    Energy Technology Data Exchange (ETDEWEB)

    El-Khoury, P

    1998-04-15

    The study of exotic atoms, in which an orbiting electron of a normal atom is replaced by a negatively charged particle ({pi}{sup -}, {mu}{sup -}, p, {kappa}{sup -}, {sigma}{sup -},...) may provide information on the orbiting particle and the atomic nucleus, as well as on their interaction. In this work, we were interested in pionic atoms ({pi}{sup -14} N) on the one hand in order to determine the pion mass with high accuracy (4 ppm), and on the other hand in antiprotonic atoms (pp-bar) in order to study the strong nucleon-antinucleon interaction at threshold. In this respect, a high-resolution crystal spectrometer was coupled to a cyclotron trap which provides a high stop density for particles in gas targets at low pressure. Using curved crystals, an extended X-ray source could be imaged onto the detector. Charge-Coupled Devices were used as position sensitive detectors in order to measure the Bragg angle of the transition to a high precision. The use of gas targets resolved the ambiguity owing to the number of K electrons for the value of the pion mass, and, for the first time, strong interaction shift and broadening of the 2p level in antiprotonic hydrogen were measured directly. (author)

  20. Technological advances in radiotherapy of rectal cancer

    DEFF Research Database (Denmark)

    Appelt, Ane L; Sebag-Montefiore, David

    2016-01-01

    PURPOSE OF REVIEW: This review summarizes the available evidence for the use of modern radiotherapy techniques for chemoradiotherapy for rectal cancer, with specific focus on intensity-modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) techniques. RECENT FINDINGS: The dosimetric....... Overall results are encouraging, as toxicity levels - although varying across reports - appear lower than for 3D conformal radiotherapy. Innovative treatment techniques and strategies which may be facilitated by the use of IMRT/VMAT include simultaneously integrated tumour boost, adaptive treatment...

  1. Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station

    Science.gov (United States)

    Aguilar, M.; Ali Cavasonza, L.; Alpat, B.; Ambrosi, G.; Arruda, L.; Attig, N.; Aupetit, S.; Azzarello, P.; Bachlechner, A.; Barao, F.; Barrau, A.; Barrin, L.; Bartoloni, A.; Basara, L.; Başeǧmez-du Pree, S.; Battarbee, M.; Battiston, R.; Bazo, J.; Becker, U.; Behlmann, M.; Beischer, B.; Berdugo, J.; Bertucci, B.; Bindi, V.; Boella, G.; de Boer, W.; Bollweg, K.; Bonnivard, V.; Borgia, B.; Boschini, M. J.; Bourquin, M.; Bueno, E. F.; Burger, J.; Cadoux, F.; Cai, X. D.; Capell, M.; Caroff, S.; Casaus, J.; Castellini, G.; Cernuda, I.; Cervelli, F.; Chae, M. J.; Chang, Y. H.; Chen, A. I.; Chen, G. M.; Chen, H. S.; Cheng, L.; Chou, H. Y.; Choumilov, E.; Choutko, V.; Chung, C. H.; Clark, C.; Clavero, R.; Coignet, G.; Consolandi, C.; Contin, A.; Corti, C.; Coste, B.; Creus, W.; Crispoltoni, M.; Cui, Z.; Dai, Y. M.; Delgado, C.; Della Torre, S.; Demirköz, M. B.; Derome, L.; Di Falco, S.; Dimiccoli, F.; Díaz, C.; von Doetinchem, P.; Dong, F.; Donnini, F.; Duranti, M.; D'Urso, D.; Egorov, A.; Eline, A.; Eronen, T.; Feng, J.; Fiandrini, E.; Finch, E.; Fisher, P.; Formato, V.; Galaktionov, Y.; Gallucci, G.; García, B.; García-López, R. J.; Gargiulo, C.; Gast, H.; Gebauer, I.; Gervasi, M.; Ghelfi, A.; Giovacchini, F.; Goglov, P.; Gómez-Coral, D. M.; Gong, J.; Goy, C.; Grabski, V.; Grandi, D.; Graziani, M.; Guerri, I.; Guo, K. H.; Habiby, M.; Haino, S.; Han, K. C.; He, Z. H.; Heil, M.; Hoffman, J.; Hsieh, T. H.; Huang, H.; Huang, Z. C.; Huh, C.; Incagli, M.; Ionica, M.; Jang, W. Y.; Jinchi, H.; Kang, S. C.; Kanishev, K.; Kim, G. N.; Kim, K. S.; Kirn, Th.; Konak, C.; Kounina, O.; Kounine, A.; Koutsenko, V.; Krafczyk, M. S.; La Vacca, G.; Laudi, E.; Laurenti, G.; Lazzizzera, I.; Lebedev, A.; Lee, H. T.; Lee, S. C.; Leluc, C.; Li, H. S.; Li, J. Q.; Li, J. Q.; Li, Q.; Li, T. X.; Li, W.; Li, Z. H.; Li, Z. Y.; Lim, S.; Lin, C. H.; Lipari, P.; Lippert, T.; Liu, D.; Liu, Hu; Lu, S. Q.; Lu, Y. S.; Luebelsmeyer, K.; Luo, F.; Luo, J. Z.; Lv, S. S.; Majka, R.; Mañá, C.; Marín, J.; Martin, T.; Martínez, G.; Masi, N.; Maurin, D.; Menchaca-Rocha, A.; Meng, Q.; Mo, D. C.; Morescalchi, L.; Mott, P.; Nelson, T.; Ni, J. Q.; Nikonov, N.; Nozzoli, F.; Nunes, P.; Oliva, A.; Orcinha, M.; Palmonari, F.; Palomares, C.; Paniccia, M.; Pauluzzi, M.; Pensotti, S.; Pereira, R.; Picot-Clemente, N.; Pilo, F.; Pizzolotto, C.; Plyaskin, V.; Pohl, M.; Poireau, V.; Putze, A.; Quadrani, L.; Qi, X. M.; Qin, X.; Qu, Z. Y.; Räihä, T.; Rancoita, P. G.; Rapin, D.; Ricol, J. S.; Rodríguez, I.; Rosier-Lees, S.; Rozhkov, A.; Rozza, D.; Sagdeev, R.; Sandweiss, J.; Saouter, P.; Schael, S.; Schmidt, S. M.; Schulz von Dratzig, A.; Schwering, G.; Seo, E. S.; Shan, B. S.; Shi, J. Y.; Siedenburg, T.; Son, D.; Song, J. W.; Sun, W. H.; Tacconi, M.; Tang, X. W.; Tang, Z. C.; Tao, L.; Tescaro, D.; Ting, Samuel C. C.; Ting, S. M.; Tomassetti, N.; Torsti, J.; Türkoǧlu, C.; Urban, T.; Vagelli, V.; Valente, E.; Vannini, C.; Valtonen, E.; Vázquez Acosta, M.; Vecchi, M.; Velasco, M.; Vialle, J. P.; Vitale, V.; Vitillo, S.; Wang, L. Q.; Wang, N. H.; Wang, Q. L.; Wang, X.; Wang, X. Q.; Wang, Z. X.; Wei, C. C.; Weng, Z. L.; Whitman, K.; Wienkenhöver, J.; Willenbrock, M.; Wu, H.; Wu, X.; Xia, X.; Xiong, R. Q.; Xu, W.; Yan, Q.; Yang, J.; Yang, M.; Yang, Y.; Yi, H.; Yu, Y. J.; Yu, Z. Q.; Zeissler, S.; Zhang, C.; Zhang, J.; Zhang, J. H.; Zhang, S. D.; Zhang, S. W.; Zhang, Z.; Zheng, Z. M.; Zhu, Z. Q.; Zhuang, H. L.; Zhukov, V.; Zichichi, A.; Zimmermann, N.; Zuccon, P.; AMS Collaboration

    2016-08-01

    A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49 ×1 05 antiproton events and 2.42 ×1 09 proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ˜60 to ˜500 GV , the antiproton p ¯, proton p , and positron e+ fluxes are found to have nearly identical rigidity dependence and the electron e- flux exhibits a different rigidity dependence. Below 60 GV, the (p ¯/p ), (p ¯/e+), and (p /e+) flux ratios each reaches a maximum. From ˜60 to ˜500 GV , the (p ¯/p ), (p ¯/e+), and (p /e+) flux ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.

  2. Antiproton Flux, Antiproton-to-Proton Flux Ratio, and Properties of Elementary Particle Fluxes in Primary Cosmic Rays Measured with the Alpha Magnetic Spectrometer on the International Space Station.

    Science.gov (United States)

    Aguilar, M; Ali Cavasonza, L; Alpat, B; Ambrosi, G; Arruda, L; Attig, N; Aupetit, S; Azzarello, P; Bachlechner, A; Barao, F; Barrau, A; Barrin, L; Bartoloni, A; Basara, L; Başeǧmez-du Pree, S; Battarbee, M; Battiston, R; Bazo, J; Becker, U; Behlmann, M; Beischer, B; Berdugo, J; Bertucci, B; Bindi, V; Boella, G; de Boer, W; Bollweg, K; Bonnivard, V; Borgia, B; Boschini, M J; Bourquin, M; Bueno, E F; Burger, J; Cadoux, F; Cai, X D; Capell, M; Caroff, S; Casaus, J; Castellini, G; Cernuda, I; Cervelli, F; Chae, M J; Chang, Y H; Chen, A I; Chen, G M; Chen, H S; Cheng, L; Chou, H Y; Choumilov, E; Choutko, V; Chung, C H; Clark, C; Clavero, R; Coignet, G; Consolandi, C; Contin, A; Corti, C; Coste, B; Creus, W; Crispoltoni, M; Cui, Z; Dai, Y M; Delgado, C; Della Torre, S; Demirköz, M B; Derome, L; Di Falco, S; Dimiccoli, F; Díaz, C; von Doetinchem, P; Dong, F; Donnini, F; Duranti, M; D'Urso, D; Egorov, A; Eline, A; Eronen, T; Feng, J; Fiandrini, E; Finch, E; Fisher, P; Formato, V; Galaktionov, Y; Gallucci, G; García, B; García-López, R J; Gargiulo, C; Gast, H; Gebauer, I; Gervasi, M; Ghelfi, A; Giovacchini, F; Goglov, P; Gómez-Coral, D M; Gong, J; Goy, C; Grabski, V; Grandi, D; Graziani, M; Guerri, I; Guo, K H; Habiby, M; Haino, S; Han, K C; He, Z H; Heil, M; Hoffman, J; Hsieh, T H; Huang, H; Huang, Z C; Huh, C; Incagli, M; Ionica, M; Jang, W Y; Jinchi, H; Kang, S C; Kanishev, K; Kim, G N; Kim, K S; Kirn, Th; Konak, C; Kounina, O; Kounine, A; Koutsenko, V; Krafczyk, M S; La Vacca, G; Laudi, E; Laurenti, G; Lazzizzera, I; Lebedev, A; Lee, H T; Lee, S C; Leluc, C; Li, H S; Li, J Q; Li, J Q; Li, Q; Li, T X; Li, W; Li, Z H; Li, Z Y; Lim, S; Lin, C H; Lipari, P; Lippert, T; Liu, D; Liu, Hu; Lu, S Q; Lu, Y S; Luebelsmeyer, K; Luo, F; Luo, J Z; Lv, S S; Majka, R; Mañá, C; Marín, J; Martin, T; Martínez, G; Masi, N; Maurin, D; Menchaca-Rocha, A; Meng, Q; Mo, D C; Morescalchi, L; Mott, P; Nelson, T; Ni, J Q; Nikonov, N; Nozzoli, F; Nunes, P; Oliva, A; Orcinha, M; Palmonari, F; Palomares, C; Paniccia, M; Pauluzzi, M; Pensotti, S; Pereira, R; Picot-Clemente, N; Pilo, F; Pizzolotto, C; Plyaskin, V; Pohl, M; Poireau, V; Putze, A; Quadrani, L; Qi, X M; Qin, X; Qu, Z Y; Räihä, T; Rancoita, P G; Rapin, D; Ricol, J S; Rodríguez, I; Rosier-Lees, S; Rozhkov, A; Rozza, D; Sagdeev, R; Sandweiss, J; Saouter, P; Schael, S; Schmidt, S M; Schulz von Dratzig, A; Schwering, G; Seo, E S; Shan, B S; Shi, J Y; Siedenburg, T; Son, D; Song, J W; Sun, W H; Tacconi, M; Tang, X W; Tang, Z C; Tao, L; Tescaro, D; Ting, Samuel C C; Ting, S M; Tomassetti, N; Torsti, J; Türkoğlu, C; Urban, T; Vagelli, V; Valente, E; Vannini, C; Valtonen, E; Vázquez Acosta, M; Vecchi, M; Velasco, M; Vialle, J P; Vitale, V; Vitillo, S; Wang, L Q; Wang, N H; Wang, Q L; Wang, X; Wang, X Q; Wang, Z X; Wei, C C; Weng, Z L; Whitman, K; Wienkenhöver, J; Willenbrock, M; Wu, H; Wu, X; Xia, X; Xiong, R Q; Xu, W; Yan, Q; Yang, J; Yang, M; Yang, Y; Yi, H; Yu, Y J; Yu, Z Q; Zeissler, S; Zhang, C; Zhang, J; Zhang, J H; Zhang, S D; Zhang, S W; Zhang, Z; Zheng, Z M; Zhu, Z Q; Zhuang, H L; Zhukov, V; Zichichi, A; Zimmermann, N; Zuccon, P

    2016-08-26

    A precision measurement by AMS of the antiproton flux and the antiproton-to-proton flux ratio in primary cosmic rays in the absolute rigidity range from 1 to 450 GV is presented based on 3.49×10^{5} antiproton events and 2.42×10^{9} proton events. The fluxes and flux ratios of charged elementary particles in cosmic rays are also presented. In the absolute rigidity range ∼60 to ∼500  GV, the antiproton p[over ¯], proton p, and positron e^{+} fluxes are found to have nearly identical rigidity dependence and the electron e^{-} flux exhibits a different rigidity dependence. Below 60 GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios each reaches a maximum. From ∼60 to ∼500  GV, the (p[over ¯]/p), (p[over ¯]/e^{+}), and (p/e^{+}) flux ratios show no rigidity dependence. These are new observations of the properties of elementary particles in the cosmos.

  3. Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer

    DEFF Research Database (Denmark)

    Vaidya, Jayant S; Wenz, Frederik; Bulsara, Max;

    2014-01-01

    The TARGIT-A trial compared risk-adapted radiotherapy using single-dose targeted intraoperative radiotherapy (TARGIT) versus fractionated external beam radiotherapy (EBRT) for breast cancer. We report 5-year results for local recurrence and the first analysis of overall survival....

  4. Role of radiotherapy in hospice care

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, Tetsuo; Sugiyama, Akira; Shimizu, Teppei; Ichinohe, Kenji; Teshima, Takeshi; Kaneko, Masao; Hara, Yoshio; Chihara, Satoshi.

    1989-01-01

    The aim of palliative radiotherapy for the terminally ill is to improve the quality of the remaining span of life. From November 1982 to September 1987, 69 patients in the Seirei Hospice have been treated with such radiotherapy, and symptomatic relief was obtained in 64% of these patients. Radiotherapy also proved useful in achieving an improvement in their performance status. While the aim of hospice care is not directed towards treatment of the underlying disease, the use of radiotherapy is considered to have an important role in hospice care.

  5. Deceleration of MeV antiprotons and muons to keV energies — the anticyclotron A progress report

    Science.gov (United States)

    Horváth, D.; Aschenauer, E. C.; Cauz, D.; Chatellard, D.; DeCecco, P.; Eades, J.; Egger, J.-P.; Elsener, K.; Eugster, P.; Formisano, F.; Gorini, G.; Hauser, P.; Kottmann, F.; Krafcsik, I.; Lagomarsino, V.; Manuzio, G.; Missimer, J.; Poggiani, R.; Simons, L. M.; Testera, G.; Torelli, G.; Waldner, F.

    1994-03-01

    A progress report is presented on the development of the anticyclotron — deceleration of antiprotons and negative muons via collisions in a low-pressure gas or thin foils during revolutions in a cyclotron field. Beam tests performed at CERN and PSI are reported and future plans for applications outlined.

  6. Deceleration of MeV antiprotons and muons to keV energies - the anticyclotron. A progress report

    Energy Technology Data Exchange (ETDEWEB)

    Horvath, D.; Aschenauer, E.C.; Cauz, D.; Chatellard, D.; DeCecco, P.; Eades, J.; Egger, J.P.; Elsener, K.; Eugster, P.; Formisano, F.; Gorini, G.; Hauser, P.; Kottmann, F.; Krafcsik, I.; Lagomarsino, V.; Manuzio, G.; Missimer, J.; Poggiani, R.; Simons, L.M.; Testera, G.; Torelli, G.; Waldner, F. (KFKI Research Inst. for Particle and Nuclear Physics, Budapest (Hungary) Pisa Univ. (Italy) INFN, Pisa (Italy) Paul Scherrer Inst., Villigen (Switzerland) Univ. di Udine (Italy) Neuchatel Univ. (Switzerland) CERN, Geneva (Switzerland) ETH Zuerich, Villigen (Switzerland) KFKI Research Inst. for Materials Science, Budapest (Hungary) Genova Univ. (Italy) INFN, Genova (Italy))

    1994-03-01

    A progress report is presented on the development of the anticyclotron - deceleration of antiprotons and negative muons via collisions in a low-pressure gas or thin foils during revolutions in a cyclotron field. Beam tests performed at CERN and PSI are reported and future plans for applications outlined. (orig.)

  7. Non-dissociative and dissociative ionisation of H sub 2 by 50-2000 keV antiprotons

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, L.H.; Hvelplund, P.; Knudsen, H.; Moeller, S.P.; Pedersen, J.O.P.; Tang-Petersen, S.; Uggerhoej, E. (Aarhus Univ. (Denmark). Inst. of Physics); Elsener, K. (European Organization for Nuclear Research, Geneva (Switzerland)); Morenzoni, E. (Paul Scherrer Inst. (PSI), Villigen (Switzerland))

    1990-08-14

    A beam of antiprotons with energies between 50 keV and 2 MeV has been used for measurements of non-dissociative ionisation and dissociative ionisation cross sections of H{sub 2}. The results are compared with cross sections for equivelocity protons and electrons, and the role of interference effects in two-electron processes is discussed. (author).

  8. Measurement of small-angle antiproton-proton and proton-proton elastic scattering at the CERN intersecting storage rings

    NARCIS (Netherlands)

    Amos, N.; Block, M.M.; Bobbink, G.J.; Botje, M.A.J.; Favart, D.; Leroy, C.; Linde, F.; Lipnik, P.; Matheys, J-P.; Miller, D.

    1985-01-01

    Antiproton-proton and proton-proton small-angle elastic scattering was measured for centre-of-mass energies at the CERN Intersectung Storage Rings. In addition, proton-proton elastic scattering was measured at . Using the optical theorem, total cross sections are obtained with an accuracy of about

  9. Peripheral giant cell granuloma

    Directory of Open Access Journals (Sweden)

    Padam Narayan Tandon

    2012-01-01

    Full Text Available Peripheral giant cell granuloma or the so-called "giant cell epulis" is the most common oral giant cell lesion. It normally presents as a soft tissue purplish-red nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This lesion probably does not represent a true neoplasm, but rather may be reactive in nature, believed to be stimulated by local irritation or trauma, but the cause is not certainly known. This article reports a case of peripheral giant cell granuloma arising at the maxillary anterior region in a 22-year-old female patient. The lesion was completely excised to the periosteum level and there is no residual or recurrent swelling or bony defect apparent in the area of biopsy after a follow-up period of 6 months.

  10. Direct measurement of transition frequencies in isolated pHe+ atoms, and new CPT-violation limits on the antiproton charge and mass.

    Science.gov (United States)

    Hori, M; Eades, J; Hayano, R S; Ishikawa, T; Pirkl, W; Widmann, E; Yamaguchi, H; Torii, H A; Juhász, B; Horváth, D; Yamazaki, T

    2003-09-19

    A radio frequency quadrupole decelerator and achromatic momentum analyzer were used to decelerate antiprotons and produce p4He+ and p3He+ atoms in ultra-low-density targets, where collision-induced shifts of the atomic transition frequencies were negligible. The frequencies at near-vacuo conditions were measured by laser spectroscopy to fractional precisions of (6-19) x 10(-8). By comparing these with QED calculations and the antiproton cyclotron frequency, we set a new limit of 1 x 10(-8) on possible differences between the antiproton and proton charges and masses.

  11. Painful peripheral neuropathy

    Directory of Open Access Journals (Sweden)

    SUN Bo

    2013-09-01

    Full Text Available Painful peripheral neuropathy (PPN is characterized by neuropathic pain (NP, which is accompanied by dysfunction of motor, sensory and autonomic nervous system. It always involves small nerve fibers, including A δ and C fibers. PPN can be classified into two types according to etiology: hereditary and acquired. Pain of PPN can manifest as spontaneous pain and stimulus-evoked pain (allodynia, hyperalgesia and hyperpathia. The manifestation of typical cases is length-dependent, which firstly involves the feet, and then progresses proximally and to the hands, presenting a glove-stock pattern. PPN can be either an isolated disease entity or part of other diseases. The former indicates idiopathic small fiber neuropathy (SFN, while the latter contains various diseases involving peripheral nerve fibers, including systemic diseases such as diabetes mellitus and peripheral neuropathy with other causes. The accessory examinations of PPN include quantitative sensory testing (QST, intraepidermal nerve fiber density (IENFD, sympathetic skin response (SSR, etc. Among them, IENFD is the "golden standard" for SFN. The major therapeutic methods are to control primary diseases and relieve pain. Medications alleviating neuropathic pain consist of carbamazepine, pregabalin, gabapentin and amitriptyline, etc.

  12. Treatment outcome in patients with vulvar cancer: comparison of concurrent radiotherapy to postoperative radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ja Young; Kim, Sung Hwan; Kim, Ki Won; Park, Dong Choon; Yoon, Joo Hee; Yoon, Sei Chul [St. Vincent' s Hospital, The Catholic University of Korea School of Medicine, Seoul (Korea, Republic of); Yu, Mina [St. Mary' s Hospital, The Catholic University of Korea School of Medicine, Seoul (Korea, Republic of)

    2012-03-15

    To evaluate outcome and morbidity in patients with vulvar cancer treated with radiotherapy, concurrent chemoradiotherapy or postoperative radiotherapy. The records of 24 patients treated with radiotherapy for vulvar cancer between July 1993 and September 2009 were retrospectively reviewed. All patients received once daily 1.8-4 Gy fractions external beam radiotherapy to median 51.2 Gy (range, 19.8 to 81.6 Gy) on pelvis and inguinal nodes. Seven patients were treated with primary concurrent chemoradiotherapy, one patient was treated with primary radiotherapy alone, four patients received palliative radiotherapy, and twelve patients were treated with postoperative radiotherapy. Twenty patients were eligible for response evaluation. Response rate was 55% (11/20). The 5-year disease free survival was 42.2% and 5-year overall survival was 46.2%, respectively. Fifty percent (12/24) experienced with acute skin complications of grade III or more during radiotherapy. Late complications were found in 8 patients. 50% (6/12) of patients treated with lymph node dissection experienced severe late complications. One patient died of sepsis from lymphedema. However, only 16.6% (2/12) of patients treated with primary radiotherapy developed late complications. Outcome of patients with vulvar cancer treated with radiotherapy showed relatively good local control and low recurrence. Severe late toxicities remained higher in patients treated with both node dissection and radiotherapy.

  13. Radiotherapy and Brachytherapy : Proceedings of the NATO Advanced Study Institute on Physics of Modern Radiotherapy & Brachytherapy

    CERN Document Server

    Lemoigne, Yves

    2009-01-01

    This volume collects a series of lectures presented at the tenth ESI School held at Archamps (FR) in November 2007 and dedicated to radiotherapy and brachytherapy. The lectures focus on the multiple facets of radiotherapy in general, including external radiotherapy (often called teletherapy) as well as internal radiotherapy (called brachytherapy). Radiotherapy strategy and dose management as well as the decisive role of digital imaging in the associated clinical practice are developed in several articles. Grouped under the discipline of Conformal Radiotherapy (CRT), numerous modern techniques, from Multi-Leaf Collimators (MLC) to Intensity Modulated RadioTherapy (IMRT), are explained in detail. The importance of treatment planning based upon patient data from digital imaging (Computed Tomography) is also underlined. Finally, despite the quasi- totality of patients being presently treated with gamma and X-rays, novel powerful tools are emerging using proton and light ions (like carbon ions) beams, bound to bec...

  14. Radiotherapy versus combined modality in early stages

    DEFF Research Database (Denmark)

    Specht, L.; Carde, P.; Mauch, P.;

    1992-01-01

    In early stage Hodgkin's disease the optimal choice of treatment for the individual patient is still an unresolved issue. So far, twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out worldwide. The preliminary results of a glob...

  15. [Radiotherapy promises: focus on lung cancer].

    Science.gov (United States)

    Jouin, Anaïs; Durand-Labrunie, Jérôme; Leroy, Thomas; Pannier, Diane; Wagner, Antoine; Rault, Erwan; Lartigau, Eric

    2013-06-01

    Radiotherapy is a key cancer treatment, which greatly modified its practice in recent years thanks to medical imaging and technical improvements. The systematic use of computed tomography (CT) for treatment planning, the imaging fusion/co-registration between CT/magnetic resonance imaging (MRI) or CT/positron emission tomography (PET) improve target identification/selection and delineation. New irradiation techniques such as image-guided radiotherapy (IGRT), stereotactic radiotherapy or hadron therapy offer a more diverse therapeutic armamentarium to patients together with lower toxicity. Radiotherapy, as well as medical oncology, tends to offer a personalized treatment to patients thanks to the IGRT, which takes into account the inter- or intra-fraction anatomic variations. IGRT leads to adaptive radiotherapy (ART) with a new planification in the treatment course in order to decrease toxicity and improve tumor control. The use of systemic therapies with radiations needs to be studied in order to improve efficiency without increasing toxicities from these multimodal approaches. Finally, radiotherapy advances were impacted by radiotherapy accidents like Epinal. They led to an increased quality control with the intensification of identity control, the emergence of in vivo dosimetry or the experience feedback committee in radiotherapy. We will illustrate through the example of lung cancer.

  16. Quality and safety in radiotherapy

    CERN Document Server

    Pawlicki, Todd

    2010-01-01

    The first text to focus solely on quality and safety in radiotherapy, this work encompasses not only traditional, more technically oriented, quality assurance activities, but also general approaches of quality and safety. It includes contributions from experts both inside and outside the field to present a global view. The task of assuring quality is no longer viewed solely as a technical, equipment-dependent endeavor. Instead, it is now recognized as depending on both the processes and the people delivering the service. Divided into seven broad categories, the text covers: Quality Management

  17. Radiobiology of human cancer radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Andrews, J.R.

    1978-01-01

    The author has systematically collected and collated the scientific literature correlating the basic and clinical sciences in this field in order to produce a definitive treatise. The book thoroughly reviews the biology and biochemistry relevant to radiobiology and describes the critical locus for the extinction of cell reproductive capacity. Extensive coverage is given to oxygen effect, hyperthermia, high linear energy transfer, cell populations, and similar topics. Separate sections cover time, dose, and fractionation; radiation hematology; cancer chemotherapy; and cancer immunology. The book also contains invaluable discussions of techniques for optimizing radiotherapy alone and in combination with other therapies.

  18. Basic radiotherapy physics and biology

    CERN Document Server

    Chang, David S; Das, Indra J; Mendonca, Marc S; Dynlacht, Joseph R

    2014-01-01

    This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation oncology residents, radiation therapists, dosimetrists, and physicists. It presents topics that are included on the Radiation Therapy Physics and Biology examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. Basic Radiotherapy Physics and Biology is a

  19. Radiotherapy in patients with connective tissue diseases.

    Science.gov (United States)

    Giaj-Levra, Niccolò; Sciascia, Savino; Fiorentino, Alba; Fersino, Sergio; Mazzola, Rosario; Ricchetti, Francesco; Roccatello, Dario; Alongi, Filippo

    2016-03-01

    The decision to offer radiotherapy in patients with connective tissue diseases continues to be challenging. Radiotherapy might trigger the onset of connective tissue diseases by increasing the expression of self-antigens, diminishing regulatory T-cell activity, and activating effectors of innate immunity (dendritic cells) through Toll-like receptor-dependent mechanisms, all of which could potentially lead to breaks of immune tolerance. This potential risk has raised some debate among radiation oncologists about whether patients with connective tissue diseases can tolerate radiation as well as people without connective tissue diseases. Because the number of patients with cancer and connective tissue diseases needing radiotherapy will probably increase due to improvements in medical treatment and longer life expectancy, the issue of interactions between radiotherapy and connective tissue diseases needs to be clearer. In this Review, we discuss available data and evidence for patients with connective tissue diseases treated with radiotherapy.

  20. Sixfold improved single particle measurement of the magnetic moment of the antiproton

    CERN Document Server

    Nagahama, H; Sellner, S; Harrington, J; Higuchi, T; Borchert, M J; Tanaka, T; Besirli, M; Mooser, A; Schneider, G; Blaum, K; Matsuda, Y; Ospelkaus, C; Quint, W; Walz, J; Yamazaki, Y; Ulmer, S

    2017-01-01

    Our current understanding of the Universe comes, among others, from particle physics and cosmology. In particle physics an almost perfect symmetry between matter and antimatter exists. On cosmological scales, however, a striking matter/antimatter imbalance is observed. This contradiction inspires comparisons of the fundamental properties of particles and antiparticles with high precision. Here we report on a measurement of the g-factor of the antiproton with a fractional precision of 0.8 parts per million at 95% confidence level. Our value /2=2.7928465(23) outperforms the previous best measurement by a factor of 6. The result is consistent with our proton g-factor measurement gp/2=2.792847350(9), and therefore agrees with the fundamental charge, parity, time (CPT) invariance of the Standard Model of particle physics. Additionally, our result improves coefficients of the standard model extension which discusses the sensitivity of experiments with respect to CPT violation by up to a factor of 20.

  1. Measurement of (anti)deuteron and (anti)proton production in DIS at HERA

    Energy Technology Data Exchange (ETDEWEB)

    Chekanov, S.; Derrick, M.; Magill, S. [Argonne National Laboratory, Argonne, IL (US)] (and others)

    2007-05-15

    The first observation of (anti)deuterons in deep inelastic scattering at HERA has been made with the ZEUS detector at a centre-of-mass energy of 300-318 GeV using an integrated luminosity of 120 pb{sup -1}. The measurement was performed in the central rapidity region for transverse momentum per unit of mass in the range 0.3anti)proton yield by approximately three orders of magnitude, consistent with the world measurements. (orig.)

  2. Stopping power of antiprotons in H, H2, and He targets

    DEFF Research Database (Denmark)

    Lühr, Armin Christian; Saenz, Alejandro

    2009-01-01

    The stopping power of antiprotons in atomic and molecular hydrogen as well as helium was calculated in an impact-energy range from 1 keV to 6.4 MeV. In the case of H2 and He the targets were described with a single-active electron model centered on the target. The collision process was treated...... of the corrections to the first-order stopping number, the average energy transferred to the target electrons, and the relative importance of the excitation and the ionization process for the energy loss of the projectile was determined. Finally, the stopping powers of the H, H2, and He targets were directly...

  3. Caloric curve of 8 GeV/c negative pion and antiproton + Au reactions

    CERN Document Server

    Ruangma, A; Martin, E; Ramakrishnan, E; Rowland, D J; Veselsky, M; Winchester, E M; Yennello, S J; Beaulieu, L; Hsi, W C; Kwiatkowski, K K; Lefort, T; Viola, V E; Botvina, A; Korteling, R G; Pienkowski, L; Breuer, H; Gushue, S; Remsberg, L P

    2002-01-01

    The relationship between nuclear temperature and excitation energy of hot nuclei formed by 8 GeV/c negative pion and antiproton beams incident on 197Au has been investigated with the ISiS 4-pidetector array at the BNL AGS accelerator. The double-isotope-ratio technique was used to calculate the temperature of the hot system. The two thermometers used (p/d-3He/4He) and (d/t-3He/4He) are in agreement below E*/A ~ 7 MeV when corrected for secondary decay. Comparison of these caloric curves to those from other experiments shows some differences that may be attributable to instrumentation and analysis procedures. The caloric curves from this experiment are also compared with the predictions from the SMM multifragmentation model.

  4. Nuclear fragmentation induced by low-energy antiprotons within a microscopic transport approach

    CERN Document Server

    Feng, Zhao-Qing

    2016-01-01

    Within the framework of the Lanzhou quantum molecular dynamics (LQMD) transport model, the nuclear fragmentation induced by low-energy antiprotons has been investigated thoroughly. A coalescence approach is developed for constructing the primary fragments in phase space. The secondary decay process of the fragments is described by the well-known statistical code. It is found that the localized energy released in antibaryon-baryon annihilation is deposited in a nucleus mainly via pion-nucleon collisions, which leads to the emissions of pre-equilibrium particles, fission, evaporation of nucleons and light fragments etc. The strangeness exchange reactions dominate the hyperon production. The averaged mass loss increases with the mass number of target nucleus. A bump structure in the domain of intermediate mass for heavy targets appears owing to the contribution of fission fragments.

  5. Theoretical motivation for gravitation experiments on ultra-low energy antiprotons and antihydrogen

    CERN Document Server

    Nieto, Michael Martin; Anderson, J D; Lau, E L; Pérez-Mercader, J; Nieto, Michael Martin; Goldman, T; Anderson, John D; Lau, Eunice L; Perez-Mercader, J

    1994-01-01

    We know that the generally accepted theories of gravity and quantum mechanics are fundamentally incompatible. Thus, when we try to combine these theories, we must beware of physical pitfalls. Modern theories of quantum gravity are trying to overcome these problems. Any ideas must confront the present agreement with general relativity, but yet be free to wonder about not understood phenomena, such as the dark matter problem and the anomalous spacecraft data which we announce here. This all has led some ``intrepid" theorists to consider a new gravitational regime, that of antimatter. Even more ``daring" experimentalists are attempting, or considering attempting, the measurement of the gravitational force on antimatter, including low-energy antiprotons and, perhaps most enticing, antihydrogen.

  6. Decay of Hot Nuclei at Low Spins Produced by Antiproton-Annihilation in Heavy Nuclei

    CERN Multimedia

    2002-01-01

    % PS208 \\\\ \\\\ The objective of the experiment is to study (i) the thermal excitation energy distribution of antiproton-induced reactions in heavy nuclei and (ii) the decay properties of hot nuclei at low spins via evaporation, multifragmentation and fission as a function of excitation energy. The experimental set-up consists of 4-$\\pi$ detectors: the Berlin Neutron Ball~(BNB) which is a spherical shell of gadolinium-loaded scintillator liquid with an inner and outer diameter of 40 and 160~cm, respectively. This detector counts the number of evaporated neutrons in each reaction. Inside BNB there is a 4-$\\pi$ silicon ball~(BSIB) with a diameter of 20~cm consisting of 162 detectors which measure energy and multiplicity of all emitted charged nuclear particles. The particles are identified via time of flight, energy and pulse shape correlations.

  7. Nuclear fragmentation induced by low-energy antiprotons within a microscopic transport approach

    Science.gov (United States)

    Feng, Zhao-Qing

    2016-12-01

    Within the framework of the Lanzhou quantum molecular-dynamics transport model, the nuclear fragmentation induced by low-energy antiprotons has been investigated thoroughly. A coalescence approach is developed for constructing the primary fragments in phase space. The secondary decay process of the fragments is described by a well-known statistical code. It is found that the localized energy released in antibaryon-baryon annihilation is deposited in a nucleus mainly via pion-nucleon collisions, which leads to the emissions of pre-equilibrium particles, fission, evaporation of nucleons, light fragments, etc. The strangeness exchange reactions dominate the hyperon production. The averaged mass loss increases with the mass number of target nucleus. A bump structure in the domain of intermediate mass for heavy targets appears owing to the contribution of fission fragments.

  8. Toward polarized antiprotons: Machine development for spin-filtering experiments at COSY

    CERN Document Server

    Weidemann, C; Stein, H J; Lorentz, B; Bagdasarian, Z; Barion, L; Barsov, S; Bechstedt, U; Bertelli, S; Chiladze, D; Ciullo, G; Contalbrigo, M; Dymov, S; Engels, R; Gaisser, M; Gebel, R; Goslawski, P; Grigoriev, K; Guidoboni, G; Kacharava, A; Kamerdzhiev, V; Khoukaz, A; Kulikov, A; Lehrach, A; Lenisa, P; Lomidze, N; Macharashvili, G; Maier, R; Martin, S; Mchedlishvili, D; Meyer, H O; Merzliakov, S; Mielke, M; Mikirtychiants, M; Mikirtychiants, S; Nass, A; Nikolaev, N N; Oellers, D; Papenbrock, M; Pesce, A; Prasuhn, D; Retzlaff, M; Schleichert, R; Schröer, D; Seyfarth, H; Soltner, H; Statera, M; Steffens, E; Stockhorst, H; Ströher, H; Tabidze, M; Tagliente, G; Engblom, P Thörngren; Trusov, S; Valdau, Yu; Vasiliev, A; Wüstner, P

    2014-01-01

    The paper describes the commissioning of the experimental equipment and the machine studies required for the first spin-filtering experiment with protons at a beam kinetic energy of $49.3\\,$MeV in COSY. The implementation of a low-$\\beta$ insertion made it possible to achieve beam lifetimes of $\\tau_{\\rm{b}}=8000\\,$s in the presence of a dense polarized hydrogen storage-cell target of areal density $d_{\\rm t}=(5.5\\pm 0.2)\\times 10^{13}\\,\\mathrm{atoms/cm^{2}}$. The developed techniques can be directly applied to antiproton machines and allow for the determination of the spin-dependent $\\bar{p}p$ cross sections via spin filtering.

  9. An explanation of the elliptic flow difference between proton and anti-proton from the UrQMD model with hadron potentials

    CERN Document Server

    Li, Qingfeng; Wang, Xiaobao; Shen, Caiwan

    2016-01-01

    The time evolution of both proton and anti-proton $v_2$ flows from Au+Au collisions at $\\sqrt{s_{NN}}$=7.7 GeV are examined by using both pure cascade and mean-field potential versions of the UrQMD model. Due to a stronger repulsion at the early stage introduced by the repulsive potentials and hence much less annihilation probabilities, anti-protons are frozen out earlier with smaller $v_2$ values. Therefore, the experimental data of anti-proton $v_2$ as well as the flow difference between proton and anti-proton can be reasonably described with the potential version of UrQMD.

  10. Peripheral ossifying fibroma

    Directory of Open Access Journals (Sweden)

    Ameet Mani

    2010-01-01

    Full Text Available The peripheral ossifying fibroma (POF is an exophytic gingival mass of fibrous connective tissue covered with a surface epithelium associated with the formation of randomly dispersed foci of a mineralized product consisting of bone, cementum-like tissue, or dystrophic calcifications having a recurrent rate of nearly 20%. It is one of the most common reactive gingival lesions, which have often been called by the generic term "epulis." This case report describes the clinical and histopathological findings of POF, its differential diagnosis, and treatment.

  11. Optimization of human cancer radiotherapy

    CERN Document Server

    Swan, George W

    1981-01-01

    The mathematical models in this book are concerned with a variety of approaches to the manner in which the clinical radiologic treatment of human neoplasms can be improved. These improvements comprise ways of delivering radiation to the malignan­ cies so as to create considerable damage to tumor cells while sparing neighboring normal tissues. There is no unique way of dealing with these improvements. Accord­ ingly, in this book a number of different presentations are given. Each presentation has as its goal some aspect of the improvement, or optimization, of radiotherapy. This book is a collection of current ideas concerned with the optimization of human cancer radiotherapy. It is hoped that readers will build on this collection and develop superior approaches for the understanding of the ways to improve therapy. The author owes a special debt of thanks to Kathy Prindle who breezed through the typing of this book with considerable dexterity. TABLE OF CONTENTS Chapter GENERAL INTRODUCTION 1. 1 Introduction 1...

  12. [Autonomic peripheral neuropathy].

    Science.gov (United States)

    Adams, David; Cauquil, Cecile; Lozeron, Pierre

    2012-11-01

    The mechanisms of dysautonomic disturbances are varied and mostly acquired. They can result from lesions of sympathetic or parasympathetic vegetative fibers located in the peripheral contingent, or in the somatic contingent by demyelination or axonal loss; or more rarely by cellular bodies in the sympathetic or parasympathetic ganglia. Several chronic peripheral neuropathies can be associated with dysautonomia. Only some causes need to be known because they can be clinically significant. Dysautonomia may be seen during chronic acquired neuropathies but also acute or subacute ones. The most frequent cause in the world is the dysautonomia of the diabetes; it affects all the systems; the cardiovascular dysfunction has an impact on the prognosis for survival when it is severe. Hereditary autonomic neuropathies are rare; they can declare themselves very early during the Riley-Day syndrome or very late during amyloid polyneuropathies due to transthyretin gene mutation. The diagnosis can be confirmed by molecular biology. The dysautonomia is frequent and often severe. These neuropathies justify symptomatic treatment to improve quality of life. For some of them, a specific treatment can be proposed to treat the causal affection to try to stop the progression of the disease.

  13. Psychological and physical distress of cancer patients during radiotherapy

    CERN Document Server

    König, A

    2001-01-01

    Purpose: patients undergoing radiotherapy have physical and psychological symptoms related to the underlying disease and the treatment. In order to give the best possible support to the patients, more knowledge about the amount and the changing of distress in the course of radiotherapy is of essentially importance. Methods: The distress was measured in a consecutive sample of cancer patients (n=82) undergoing radiotherapy. Each patient was given the EORTC-QLQ-C30, the HADS and a special questionnaire which ascertain radiotherapy-specific items before starting the radiotherapy, at the onset of radiotherapy, in the third week of radiotherapy and 3 weeks after the end of radiotherapy. Results: within the first week of treatment the psychological distress of the patients is increasing; 98.8 % of the patients are 'moderate distressed', 46 % 'severe distressed'. General physical symptoms seem not to be affected by the radiotherapy, there is no changing. The distress caused by the organization of the radiotherapy is...

  14. Measurement of the Antiprotonic Lyman- and Balmer X-rays of $\\overline{p}H$ and $\\overline{p}D$ Atoms at Very Low Target Pressures

    CERN Multimedia

    2002-01-01

    The aim of this experiment is to measure the energies and intensities of the n @A 1 (Lyman) and n @A 2 (Balmer) tansitions with high accuracy in both @*H and @*D, from which the strong interaction effects of the 1s- and 2p-level can be extracted. These observables may be related to the antiproton-proton and antiproton-neutron scattering length. \\\\ \\\\ Since in these targets collisional Stark effect occurs, we will stop the antiprotons in extreme thin gaseous targets (pressure as low as 10 Torr), where no Stark effect occurs and the 2-1 transition is favoured. In order to use antiprotons with high efficiency despite of the low target density, we will trap antiprotons of a momentum of 100 MeV/c in a magnetic field of cyclotron characteristics. The antiprotons are decelerated by their energy loss in the target gas. The focusing properties of the magnetic field serve to compensate the multiple scattering and we will end up with a concentrated stopping distribution at the centre. Due to the long orbiting time, back...

  15. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

    Directory of Open Access Journals (Sweden)

    Kang Ki-Mun

    2011-06-01

    Full Text Available Abstract Background Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL. Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy. Methods A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM. The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. Results The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. Conclusions Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects.

  16. Adjuvant radiotherapy for gallbladder cancer: A dosimetric comparison of conformal radiotherapy and intensity-modulated radiotherapy

    Institute of Scientific and Technical Information of China (English)

    Xiao-Nan Sun; Qi Wang; Ben-Xing Gu; Yan-Hong Zhu; Jian-Bin Hu; Guo-Zhi Shi; Shu Zheng

    2011-01-01

    AIM: To assess the efficacy and toxicity of conformal radiotherapy (CRT) and compare with intensity-modulated radiotherapy (IMRT) in the treatment of gallbladder cancer.METHODS: Between November 2003 and January 2010, 20 patients with gallbladder cancer were treated with CRT with or without chemotherapy after surgical resection. Preliminary survival data were collected and examined using both Kaplan-Meier and actuarial analysis. Demographic and treatment parameters were collected. All patients were planned to receive 46-56 Gy in 1.8 or 2.0 Gy per fraction. CRT planning was compared with IMRT.RESULTS: The most common reported acute toxicities requiring medication (Radiation Therapy Oncology Group, Radiation Therapy Oncology Group Grade2) were nausea (10/20 patients) and diarrhea (3/20).There were no treatment-related deaths. Compared with CRT planning, IMRT significantly reduced the volume of right kidney receiving > 20 Gy and the volume of liver receiving > 30 Gy. IMRT has a negligible impact on the volume of left kidney receiving > 20 Gy. The 95% of prescribed dose for a planning tumor volume using either 3D CRT or IMRT planning were 84.0% ±6.7%, 82.9% ± 6.1%, respectively (P > 0.05).CONCLUSION: IMRT achieves similar excellent target coverage as compared with CRT planning, while reducingthe mean liver dose and volume above threshold dose. IMRT offers better sparing of the right kidney compared with CRT planning, with a significantly lower mean dose and volume above threshold dose.

  17. [Current status and perspectives of radiotherapy for esophageal cancer].

    Science.gov (United States)

    Wu, S X; Wang, L H

    2016-09-23

    Esophageal cancer is one of the most common cancers in China. More than 80% of esophageal cancer patients are diagnosed at a late stage and are not eligible for surgery. Radiotherapy is one of the most important modalities in esophageal cancer treatment. Here we reviewed the advances in esophageal cancer radiotherapy and radiotherapy-based combined-modality therapy, such as optimization of radiation dose and target volume, application of precise radiotherapy technique and the integration of radiotherapy with chemotherapy and targeted therapy.

  18. Radiotherapy for MTRA/RT; Strahlentherapie fuer MTRA/RT

    Energy Technology Data Exchange (ETDEWEB)

    Luetter, Christiana [Bonn Univ. (Germany). Radiologische Klinik

    2012-07-01

    The radiological practice textbook covers the following issues: tumor diseases, tumor diagnostics, fundamentals of radiotherapy, DIN, irradiation planning, documentation and quality assurance, strategies of tumor therapy, basic physics of radiotherapy and dosimetry, radiation protection - regulations and guidelines, radiobiology, biological radiation effects, special organ toxicity, psychological and medical attendance of patients, special oncology of the most important organ carcinomas, palliative radiotherapy, radiotherapy of benign diseases, other indications of radiotherapy, supportive therapy.

  19. Drug-induced peripheral neuropathy

    DEFF Research Database (Denmark)

    Vilholm, Ole Jakob; Christensen, Alex Alban; Zedan, Ahmed;

    2014-01-01

    Peripheral neuropathy can be caused by medication, and various descriptions have been applied for this condition. In this MiniReview, the term 'drug-induced peripheral neuropathy' (DIPN) is used with the suggested definition: Damage to nerves of the peripheral nervous system caused by a chemical...... substance used in the treatment, cure, prevention or diagnosis of a disease. Optic neuropathy is included in this definition. A distinction between DIPN and other aetiologies of peripheral neuropathy is often quite difficult and thus, the aim of this MiniReview is to discuss the major agents associated...

  20. Thermal excitation of heavy nuclei with 5-15 GeV/c antiproton, proton and pion beams

    CERN Document Server

    Beaulieu, L; Hsi, W C; Lefort, T; Pienkowski, L; Korteling, R G; Wang, G; Back, B B; Bracken, D S; Breuer, H; Cornell, E A; Gimeno-Nogues, F; Ginger, D S; Gushue, S; Huang, M J; Laforest, R; Lynch, W G; Martin, E; Morley, K B; Ramakrishnan, E; Remsberg, L P; Rowland, D; Ruangma, A; Tsang, M B; Viola, V E; Winchester, E M; Xi, H; Yennello, S J

    1999-01-01

    Excitation-energy distributions have been derived from measurements of 5.0-14.6 GeV/c antiproton, proton and pion reactions with $^{197}$Au target nuclei, using the ISiS 4$\\pi$ detector array. The maximum probability for producing high excitation-energy events is found for the antiproton beam relative to other hadrons, $^3$He and $\\bar{p}$ beams from LEAR. For protons and pions, the excitation-energy distributions are nearly independent of hadron type and beam momentum above about 8 GeV/c. The excitation energy enhancement for $\\bar{p}$ beams and the saturation effect are qualitatively consistent with intranuclear cascade code predictions. For all systems studied, maximum cluster sizes are observed for residues with E*/A $\\sim$ 6 MeV.

  1. Liquid helium-free cryostat and hermetically sealed cryogenic microwave cavity for hyperfine spectroscopy of antiprotonic helium.

    Science.gov (United States)

    Massiczek, O; Friedreich, S; Juhász, B; Widmann, E; Zmeskal, J

    2011-12-11

    The design and properties of a new cryogenic set-up for laser-microwave-laser hyperfine structure spectroscopy of antiprotonic helium - an experiment performed at the CERN-Antiproton Decelerator (AD), Geneva, Switzerland - are described. Similar experiments for (4)He have been performed at the AD for several years. Due to the usage of a liquid helium operated cryostat and therefore necessary refilling of coolants, a loss of up to 10% beamtime occurred. The decision was made to change the cooling system to a closed-circuit cryocooler. New hermetically sealed target cells with minimised (3)He gas volume and different dimensions of the microwave resonator for measuring the (3)He transitions were needed. A new set-up has been designed and tested at Stefan Meyer Institute in Vienna before being used for the 2009 and 2010 beamtimes at the AD.

  2. Liquid helium-free cryostat and hermetically sealed cryogenic microwave cavity for hyperfine spectroscopy of antiprotonic helium

    Energy Technology Data Exchange (ETDEWEB)

    Massiczek, O., E-mail: oswald.massiczek@cern.ch [Stefan Meyer Institute for Subatomic Physics, Austrian Academy of Sciences, Boltzmanngasse 3, 1090 Vienna (Austria); Friedreich, S.; Juhasz, B.; Widmann, E.; Zmeskal, J. [Stefan Meyer Institute for Subatomic Physics, Austrian Academy of Sciences, Boltzmanngasse 3, 1090 Vienna (Austria)

    2011-12-11

    The design and properties of a new cryogenic set-up for laser-microwave-laser hyperfine structure spectroscopy of antiprotonic helium - an experiment performed at the CERN-Antiproton Decelerator (AD), Geneva, Switzerland - are described. Similar experiments for {sup 4}He have been performed at the AD for several years. Due to the usage of a liquid helium operated cryostat and therefore necessary refilling of coolants, a loss of up to 10% beamtime occurred. The decision was made to change the cooling system to a closed-circuit cryocooler. New hermetically sealed target cells with minimised {sup 3}He gas volume and different dimensions of the microwave resonator for measuring the {sup 3}He transitions were needed. A new set-up has been designed and tested at Stefan Meyer Institute in Vienna before being used for the 2009 and 2010 beamtimes at the AD.

  3. Factors influencing conformity index in radiotherapy for non-small cell lung cancer.

    LENUS (Irish Health Repository)

    Brennan, Sinead M

    2010-01-01

    The radiotherapy conformity index (CI) is a useful tool to quantitatively assess the quality of radiotherapy treatment plans, and represents the relationship between isodose distributions and target volume. A conformity index of unity implies high planning target volume (PTV) coverage and minimal unnecessary irradiation of surrounding tissues. We performed this analysis to describe the CI for lung cancer 3-dimensional conformal radiotherapy (3DCRT) and to identify clinical and technical determinants of CI, as it is not known which factors are associated with good quality 3D conformal radiotherapy treatment planning. Radiotherapy treatment plans from a database of 52 patients with inoperable Stage 1 to 3b lung cancer, on a hypofractionated 3DCRT trial were evaluated. A CI was calculated for all plans using the definition of the ICRU 62:CI = (TV\\/PTV), which is the quotient of the treated volume (TV) and the PTV. Data on patient, tumor, and planning variables, which could influence CI, were recorded and analyzed. Mean CI was 2.01 (range = 1.06-3.8). On univariate analysis, PTV (p = 0.023), number of beams (p = 0.036), medial vs. lateral tumor location (p = 0.016), and increasing tumor stage (p = 0.041) were associated with improved conformity. On multiple regression analysis, factors found to be associated with CI included central vs. peripheral tumor location (p = 0.041) and PTV size (p = 0.058). The term 3DCRT is used routinely in the literature, without any indication of the degree of conformality. We recommend routine reporting of conformity indices. Conformity indices may be affected by both planning variables and tumor factors.

  4. Factors influencing conformity index in radiotherapy for non-small cell lung cancer.

    Science.gov (United States)

    Brennan, Sinead M; Thirion, Pierre; Buckney, Steve; Shea, Carmel O; Armstrong, John

    2010-01-01

    The radiotherapy conformity index (CI) is a useful tool to quantitatively assess the quality of radiotherapy treatment plans, and represents the relationship between isodose distributions and target volume. A conformity index of unity implies high planning target volume (PTV) coverage and minimal unnecessary irradiation of surrounding tissues. We performed this analysis to describe the CI for lung cancer 3-dimensional conformal radiotherapy (3DCRT) and to identify clinical and technical determinants of CI, as it is not known which factors are associated with good quality 3D conformal radiotherapy treatment planning. Radiotherapy treatment plans from a database of 52 patients with inoperable Stage 1 to 3b lung cancer, on a hypofractionated 3DCRT trial were evaluated. A CI was calculated for all plans using the definition of the ICRU 62:CI = (TV/PTV), which is the quotient of the treated volume (TV) and the PTV. Data on patient, tumor, and planning variables, which could influence CI, were recorded and analyzed. Mean CI was 2.01 (range = 1.06-3.8). On univariate analysis, PTV (p = 0.023), number of beams (p = 0.036), medial vs. lateral tumor location (p = 0.016), and increasing tumor stage (p = 0.041) were associated with improved conformity. On multiple regression analysis, factors found to be associated with CI included central vs. peripheral tumor location (p = 0.041) and PTV size (p = 0.058). The term 3DCRT is used routinely in the literature, without any indication of the degree of conformality. We recommend routine reporting of conformity indices. Conformity indices may be affected by both planning variables and tumor factors.

  5. Radiotherapy. 2. rev. ed.; Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Wannenmacher, Michael; Debus, Juergen [Radiologische Klinik, Heidelberg (Germany). Abteilung fuer Radioonkologie und Strahlentherapie; Wenz, Frederik (ed.) [Universitaetsmedizin Mannheim (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2013-07-01

    The purpose of this medical specialty book, besides presenting the state of the art in clinical radiotherapy and radiooncology, is to explain the basic principles of medical physics and radiobiology. Following a number of chapters on general topics and theory it provides detailed coverage of the individual organ systems, briefly addressing future aspects in the process. The authors relate their view that radiooncology as a medical specialty will continue to be under pressure to change and that it will take continuous innovation to secure its status within the interdisciplinary context around the treatment of cancer patients. The authors of this, the textbook's second edition, have dedicated much space to modern methods and techniques in order to do justice to these developments.

  6. Tomodensitometry images: integration in radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Dessy, F.; Hoornaert, M.T. [Jolimont Hospital, Haine Saint Paul (France). Cancer and Nuclear Medicine Dept.; Malchair, F. [Biomed Engineering, Boncelles (France)

    1995-12-01

    With a view to utilization of CT scan images in radiotherapy, the effective energy and the linearity of four different scanners (Siemens somatom CR, HiQS, Plus and Picker PQ 2000) and two non standard scanners, simulators with CT option (Webb 1990) (Varian Ximatron and Oldelft Simulx CT) has been measured using the method described by White and Speller in 1980. When the linearity relation in presented using the density or the electron density as the abscissa, a blurred area where two different components of equal density or electron density can have two different Hounsfield`s numbers. Using the linearity relation, the density of Rando`s lung heterogeneity is determined. We calculated a treatment planning (TP) using this value and made a comparison between the TP and the real absorbed dose with was measured using diodes. The comparison between the TP and the relative Absorbed doses showed a difference of up to 4.5%.

  7. Peripheral arylation of subporphyrazines.

    Science.gov (United States)

    Higashino, Tomohiro; Rodríguez-Morgade, M Salomé; Osuka, Atsuhiro; Torres, Tomás

    2013-07-29

    Peripherally hexaarylated subporphyrazines (SubPzs) have been prepared through a Pd-catalyzed, CuTC-mediated coupling of a hexaethylsulfanylated subporphyrazine with arylboronic acids. The introduced aryl substituents strongly influence the electronic properties of the subporphyrazine through effective conjugative interaction. Aryl rings endowed with π-electron-donating groups at the para positions produce a remarkable perturbation of the electron density of the SubPz macrocycle. This is reflected through significant redshifts of the SubPz CT and Q-bands, together with increase of the molar absorptivity of the former, with respect to those exhibited by the hexaphenyl-SubPz 2 a. Moreover, the trend in the first SubPz reduction potentials correlates with the Hammett constants (σp ) corresponding to the para substituents of the aryl. The domed, extended SubPz π-system self-assembles in the solid state to form a dimeric capsule that houses a solvent molecule.

  8. Precision Measurement of Low-Energy Antiprotons with GAPS for Dark Matter and Primordial Black Hole Physics

    CERN Document Server

    Aramaki, T; von Doetinchem, P; Fuke, H; Hailey, C J; Mognet, S A I; Ong, R A; Perez, K M; Zweerink, J

    2014-01-01

    The general antiparticle spectrometer (GAPS) experiment is an indirect dark matter search focusing on antiparticles produced by WIMP annihilation and decay in the Galactic halo. In addition to the very powerful search channel provided by antideuterons, GAPS has a strong capability to measure low-energy antiprotons (0.07 $\\le$ E $\\le$ 0.25 GeV) as dark matter signatures. This is an especially effective means for probing light dark matter, whose existence has been hinted at in the direct dark matter searches, including the recent result from the CDMS-II experiment. While severely constrained by LUX and other direct dark matter searches, light dark matter candidates are still viable in an isospin- violating dark matter scenario and halo-independent analysis. Along with the excellent antideuteron sensitivity, GAPS will be able to detect an order of magnitude more low-energy antiprotons, compared to BESS and PAMELA, providing a precision measurement of low-energy antiproton flux and a unique channel for probing li...

  9. Precision Measurement of the Energies and Line Shapes of Antiprotonic Lyman and Balmer Transitions From Hydrogen and Helium Isotopes

    CERN Multimedia

    2002-01-01

    % PS207 \\\\ \\\\ For the study of the antiproton-proton and antiproton-nuclear spin-spin and spin-orbital interaction at threshold a high resolution measurement is proposed of the line shapes and energy shifts of antiprotonic K$\\alpha$ and L$\\alpha$ transitions of hydrogen and helium isotopes. The intense LEAR beam, stopped in the cyclotron trap at low gas pressure, provides a unique~X-ray~source with sufficient brightness. Charge coupled devices with their excellent background rejection and energy resolution allow a precise determination of the strong shifts and widths of the 1s hyperfine states of protonium, in addition the detection of the $\\bar{p}$D K$\\alpha$ transition should be possible. A focussing crystal spectrometer with a resolution $\\Delta$E/E of about l0$ ^- ^{4} $, which is superior in the accuracy of the energy determination by two orders of magnitude as compared to the present detection methods, will be used to measure the energies of the L$\\alpha$ transitions. This permits a first direct measure...

  10. Measurement of Cosmic Ray antiproton/proton flux ratio at TeV energies with ARGO-YBJ

    CERN Document Server

    Di Sciascio, G

    2011-01-01

    Cosmic ray antiprotons provide an important probe for the study of cosmic-ray propagation in the interstellar space and to investigate the existence of Galactic dark matter. The ARGO-YBJ experiment, located at the Yangbajing Cosmic Ray Laboratory (Tibet, P.R. China, 4300 m a.s.l., 606 g/cm$^2$), is the only experiment exploiting the full coverage approach at very high altitude presently at work. The ARGO-YBJ experiment is particularly effective in measuring the cosmic ray antimatter content via the observation of the cosmic rays Moon shadowing effect. Based on all the data recorded during the period from July 2006 through November 2009 and a full Monte Carlo simulation, we searched for the existence of the shadow produced by antiprotons at the few-TeV energy region. No evidence of the existence of antiprotons was found in this energy region. Upper limits to the antip/p flux ratio are set to 5 % at a median energy of 2 TeV and 6 % at 5 TeV with a confidence level of 90 %. In the few-TeV energy range this resul...

  11. Heavy particle radiotherapy: prospects and pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Faju, M.R.

    1980-01-01

    The use of heavy particles in radiotherapy of tumor volumes is examined. Particles considered are protons, helium ions, heavy ions, negative pions, and fast neutrons. Advantages and disadvantages are discussed. (ACR)

  12. Historical aspects of heavy ion radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Raju, M.R.

    1995-03-01

    This paper presents historical developments of heavy-ion radiotherapy including discussion of HILAC and HIMAC and discussion of cooperation between Japan and the United States, along with personal reflections.

  13. Peripheral T-Cell Lymphoma

    Science.gov (United States)

    Getting the Facts Peripheral T-Cell Lymphoma Overview Lymphoma is the most common blood cancer. The two main forms of lymphoma are Hodgkin lymphoma and ... develop into lymphomas: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Peripheral T-cell lymphoma (PTCL) ...

  14. Progress of peripheral nerve repair

    Institute of Scientific and Technical Information of China (English)

    陈峥嵘

    2002-01-01

    Study on repair of peripheral nerve injury has been proceeding over a long period of time. With the use of microsurgery technique since 1960s,the quality of nerve repair has been greatly improved. In the past 40 years, with the continuous increase of surgical repair methods, more progress has been made on the basic research of peripheral nerve repair.

  15. Progesterone and peripheral nerve regeneration

    Institute of Scientific and Technical Information of China (English)

    Fei Fan; Haichao Li; Yuwei Wang; Yanglin Zheng; Lianjun Jia; Zhihui Wang

    2006-01-01

    OBJECTIVE: To explore the effect of progesterone on peripheral nerve regeneration.DATA SOURCES: An online search of Medline and OVID databases was under taken to identify articles about progesterone and peripheral nerve regeneration published in English between January 1990 and June 2004 by using the keywords of "peripheral nerve, injury, progesterone, regeneration".STUDY SELECTION: The data were primarily screened, those correlated with progesterone and peripheral nerve regeneration were involved, and their original articles were further searched, the repetitive studies or reviews were excluded.DATA EXTRACTION: Totally 59 articles about progesterone and peripheral nerve regeneration were collected, and 26 of them were involved, the other 33 excluded ones were the repetitive studies or reviews.DATA SYNTHESIS: Recent researches found that certain amount of progesterone could be synthetized in peripheral nervous system, and the expression of progesterone receptor could be found in sensory neurons and Schwann cells. After combined with the receptor, endogenous and exogenous progesterone can accelerate the formation of peripheral nerve myelin sheath, also promote the axonal regeneration.CONCLUSION: Progesterone plays a role in protecting neurons, increasing the sensitivity of nerve tissue to nerve growth factor, and accelerating regeneration of nerve in peripheral nerve regeneration, which provides theoretical references for the treatment of demyelinated disease and nerve injury, as well as the prevention of neuroma, especially that the in vivo level of progesterone should be considered for the elderly people accompanied by neuropathy and patients with congenital luteal phase defect, which is of positive significance in guiding the treatment.

  16. Contrast-enhanced peripheral MRA

    DEFF Research Database (Denmark)

    Nielsen, Yousef W; Thomsen, Henrik S

    2012-01-01

    In the last decade contrast-enhanced magnetic resonance angiography (CE-MRA) has gained wide acceptance as a valuable tool in the diagnostic work-up of patients with peripheral arterial disease. This review presents current concepts in peripheral CE-MRA with emphasis on MRI technique and contrast...

  17. Blisters - an unusual effect during radiotherapy.

    Science.gov (United States)

    Höller, U; Schubert, T; Budach, V; Trefzer, U; Beyer, M

    2013-11-01

    The skin reaction to radiation is regularly monitored in order to detect enhanced radiosensitivity of the patient, unexpected interactions (e.g. with drugs) or any inadvertent overdosage. It is important to distinguish secondary disease from radiation reaction to provide adequate treatment and to avoid unnecessary discontinuation of radiotherapy. A case of bullous eruption or blisters during radiotherapy of the breast is presented. Differential diagnoses bullous pemphigoid, pemphigus vulgaris, and bullous impetigo are discussed and treatment described.

  18. Breast cancer radiotherapy and cardiac risk

    OpenAIRE

    Anusheel Munshi; Kaustav Talapatra; Debanarayan Dutta

    2011-01-01

    Breast cancer is the leading cause of morbidity and mortality in women in the developed world and its incidence in the developing world is on the rise. Management of breast cancer requires a multimodality approach and an integration of the services of surgery, radiation, and medical oncology. Radiotherapy after mastectomy or breast conservation leads to reduction in local recurrence by two-thirds. Recent trials and metaanalyses have also demonstrated overall survival benefit with radiotherapy...

  19. Radiotherapy in Dupuytren's contracture

    Energy Technology Data Exchange (ETDEWEB)

    Koehler, A.H. (Bezirkskrankenhaus Cottbus (German Democratic Republic))

    1984-01-01

    In Dupuytren's contracture grade I by Iselin radiotherapy is indicated. With X-ray half-depth therapy and a total dose of 20.0 Gy the disease could be treated successfully in 82 % of the cases in a sense of inhibition of progression, whereas in 18 % radiotherapy failed. Possibly the results can be improved by increase of the radiation dose and/or modified fractionating.

  20. Peripheral dentinogenic ghost cell tumor

    Directory of Open Access Journals (Sweden)

    Sushant S Kamat

    2013-01-01

    Full Text Available Dentinogenic ghost cell tumors (DGCT are uncommon lesions mainly with rare peripheral types. This report presents a case of peripheral DGCT on the left side of the mandibular alveolar ridge of a heavy smoker, a 68-year-old man, with main presenting feature as a mild pain. Submandibular lymphadenopathy and radiological "saucerization" were evident. Differential diagnosis included fibroma, neurofibroma, peripheral ameloblastoma, peripheral odontogenic fibroma, and peripheral giant cell granuloma. Histologically, ameloblastoma-like epithelial elements were seen in association with grouped ghost cells. Proliferating polyhedral cells and stellate reticulum-like cells with various densities were spread over a wide range of the field. The lesion was curetted and after 2 years of follow up, it did not recur.

  1. Paravaginal peripheral primitive neuroectodermal tumor: A rare tumor

    Directory of Open Access Journals (Sweden)

    Samrat Dutta

    2011-01-01

    Full Text Available Peripheral primitive neuroectodermal tumor (PNET of the female genital tract, particularly those in the vaginal and paravaginal region, are extremely rare. A 36-year-old woman presented with clinical features similar to that of a case of cervical fibroid. It was only after surgery that the histopathology suggested it to be a malignant round cell tumour and was CD99 positive. She underwent adjuvant chemotherapy with the Ifosfamide and Etoposide alternating with Vincristine, Doxorubicin, and Cyclophosphamide regime and radical radiotherapy. She is disease free at 12 months of follow-up. The importance of immunostaining and adequate histopathology report lies in the fact that the correct diagnosis thus achieved enabled us to manage a rare case of paravaginal PNET with a multimodality approach.

  2. Primary malignant peripheral nerve sheath tumor at unusual location

    Directory of Open Access Journals (Sweden)

    Souvagya Panigrahi

    2013-01-01

    Full Text Available Malignant peripheral nerve sheath tumor (MPNST is a rare soft tissue sarcoma. Most arise in association with major nerve trunks. Their most common anatomical sites are the proximal portions of the upper and lower extremities and the trunk. MPNSTs have rarely been reported in literature to occur in other unusual body parts. We review all such cases reported till now in terms of site of origin, surgical treatment, adjuvant therapy and outcome and shortly describe our experience with two of these cases. Both of our case presented with lump at unusual sites resembling neurofibroma, one at orbitotemporal area and other in the paraspinal region with characteristic feature of neurofibroma with the exception that both had very short history of progression. They underwent gross total removal of the tumor with adjuvant radiotherapy postoperatively. At 6-month follow-up both are doing well with no evidence of recurrence.

  3. Radiotherapy for pain management of bone metastases

    Energy Technology Data Exchange (ETDEWEB)

    Rezende Junior, Ismar de; Mattos, Marcos Duarte de; Nakamura, Ricardo; Lemes Junior, Joaquim; Vanzelli, Talita Lozano, E-mail: rezende.med@terra.com.br [Radioterapia do Hospital de Cancer de Barretos, SP (Brazil)

    2011-07-01

    Purpose: This is the first Brazilian study intended to evaluate the response of pain relief with radiotherapy in three different fractionation and the clinical differences in managing pain in patients with painful bone metastases. Methods: Prospective study of patients with painful bone metastases referred to the Radiotherapy Sector of the Hospital de Cancer de Barretos for pain-relieving radiotherapy between March and December 2010. It is known that radiotherapy seems to alter the activation of osteoclast-mediated bone resorption, relieving pain in cases of painful bone metastases. Patients were assessed in relation to the status of pain intensity before and after the initiation of radiotherapy. Either a single fraction of 8Gy, five fractions of 4Gy or ten fractions of 3Gy were given. A visual analog scale (VAS) was applied by doctors, nurses and nursing technicians to assess pain intensity at each session of radiotherapy, and follow-up at 8, 30 and 90 days from the end of treatment. Results: We evaluated 92 consecutive patients, 48 male and 44 female, with a median age of 58 years. We found that 14% of patients referred from the Palliative Care or Clinical Oncology sectors need better pharmacological analgesia due to severe pain, compared with 40.5% of patients from the other sectors (p = 0.004). We also found that the onset of pain relief to patients receiving 10 fractions of 300cGy analgesia without changing the pre-radiotherapy analgesia occurred with significance after the fifth fraction. Improvement in pain experienced within 90 days of follow-up was found in eighty percent of patients, independent of fractionated radiotherapy, site of metastases and the clinical condition of the patient. Discussion/Conclusion: The Palliative Care and Clinical Oncology sectors expressed greater concern in regards to analgesia for the patient with painful bone metastases. Radiotherapy is an effective pain-relieving treatment in different fractionation studied, even though the

  4. Current peripheral bypass surgery: various clinical studies

    NARCIS (Netherlands)

    Slaa, Alexander te

    2011-01-01

    Substantial post-operative edema occurs in the majority of patients who undergo peripheral bypass surgery due to severe peripheral arterial disease (PAD). The pathophysiological mechanisms that underlay edema formation following peripheral bypass surgery include hyperemia, an increased capillary per

  5. Peripheral Auditory Mechanisms

    CERN Document Server

    Hall, J; Hubbard, A; Neely, S; Tubis, A

    1986-01-01

    How weIl can we model experimental observations of the peripheral auditory system'? What theoretical predictions can we make that might be tested'? It was with these questions in mind that we organized the 1985 Mechanics of Hearing Workshop, to bring together auditory researchers to compare models with experimental observations. Tbe workshop forum was inspired by the very successful 1983 Mechanics of Hearing Workshop in Delft [1]. Boston University was chosen as the site of our meeting because of the Boston area's role as a center for hearing research in this country. We made a special effort at this meeting to attract students from around the world, because without students this field will not progress. Financial support for the workshop was provided in part by grant BNS- 8412878 from the National Science Foundation. Modeling is a traditional strategy in science and plays an important role in the scientific method. Models are the bridge between theory and experiment. Tbey test the assumptions made in experim...

  6. Epigenetics and Peripheral Artery Disease.

    Science.gov (United States)

    Golledge, Jonathan; Biros, Erik; Bingley, John; Iyer, Vikram; Krishna, Smriti M

    2016-04-01

    The term epigenetics is usually used to describe inheritable changes in gene function which do not involve changes in the DNA sequence. These typically include non-coding RNAs, DNA methylation and histone modifications. Smoking and older age are recognised risk factors for peripheral artery diseases, such as occlusive lower limb artery disease and abdominal aortic aneurysm, and have been implicated in promoting epigenetic changes. This brief review describes studies that have associated epigenetic factors with peripheral artery diseases and investigations which have examined the effect of epigenetic modifications on the outcome of peripheral artery diseases in mouse models. Investigations have largely focused on microRNAs and have identified a number of circulating microRNAs associated with human peripheral artery diseases. Upregulating or antagonising a number of microRNAs has also been reported to limit aortic aneurysm development and hind limb ischemia in mouse models. The importance of DNA methylation and histone modifications in peripheral artery disease has been relatively little studied. Whether circulating microRNAs can be used to assist identification of patients with peripheral artery diseases and be modified in order to improve the outcome of peripheral artery disease will require further investigation.

  7. How to irradiate bone metastases?; Radiotherapie des metastases osseuses: quel est le meilleur schema de radiotherapie?

    Energy Technology Data Exchange (ETDEWEB)

    Pradier, O.; Bouchekoua, M.; Albargach, N.; Muller, M.; Malhaire, J.P. [Centre Hospitalier Universitaire, Service de Radiotherapie, Institut de Cancerologie et d' Hematologie, 29 - Brest (France)

    2008-12-15

    Radiotherapy for bone metastases represents an important part of daily practice in our departments of radiotherapy. Majority of treatments deliver either one fraction (6 to 10 Gy) or multi-fractions mainly using 30 Gy in ten fractions. In the past decade, several randomized trials aimed to determine the optimal scheme of radiotherapy in this setting. In the present review, the efficacy of radiotherapy on bone metastases will be evaluated using the following parameters: the partial or complete responses on pain, the reduction of antalgic intake, bone re-calcification, and need for reirradiation. Other parameters must also be considered, such as the primary site, number of metastasis, performance status, overall prognosis and side effects of radiotherapy. (authors)

  8. A Study of the Energy Dependence of the Underlying Event in Proton-Antiproton Collisions

    CERN Document Server

    Aaltonen, Timo Antero; Amerio, Silvia; Amidei, Dante E; Anastassov, Anton Iankov; Annovi, Alberto; Antos, Jaroslav; Apollinari, Giorgio; Appel, Jeffrey A; Arisawa, Tetsuo; Artikov, Akram Muzafarovich; Asaadi, Jonathan A; Ashmanskas, William Joseph; Auerbach, Benjamin; Aurisano, Adam J; Azfar, Farrukh A; Badgett, William Farris; Bae, Taegil; Barbaro-Galtieri, Angela; Barnes, Virgil E; Barnett, Bruce Arnold; Barria, Patrizia; Bartos, Pavol; Bauce, Matteo; Bedeschi, Franco; Behari, Satyajit; Bellettini, Giorgio; Bellinger, James Nugent; Benjamin, Douglas P; Beretvas, Andrew F; Bhatti, Anwar Ahmad; Bland, Karen Renee; Blumenfeld, Barry J; Bocci, Andrea; Bodek, Arie; Bortoletto, Daniela; Boudreau, Joseph Francis; Boveia, Antonio; Brigliadori, Luca; Bromberg, Carl Michael; Brucken, Erik; Budagov, Ioulian A; Budd, Howard Scott; Burkett, Kevin Alan; Busetto, Giovanni; Bussey, Peter John; Butti, Pierfrancesco; Buzatu, Adrian; Calamba, Aristotle; Camarda, Stefano; Campanelli, Mario; Canelli, Florencia; Carls, Benjamin; Carlsmith, Duncan L; Carosi, Roberto; Carrillo Moreno, Salvador; Casal Larana, Bruno; Casarsa, Massimo; Castro, Andrea; Catastini, Pierluigi; Cauz, Diego; Cavaliere, Viviana; Cerri, Alessandro; Cerrito, Lucio; Chen, Yen-Chu; Chertok, Maxwell Benjamin; Chiarelli, Giorgio; Chlachidze, Gouram; Cho, Kihyeon; Chokheli, Davit; Clark, Allan Geoffrey; Clarke, Christopher Joseph; Convery, Mary Elizabeth; Conway, John Stephen; Corbo, Matteo; Cordelli, Marco; Cox, Charles Alexander; Cox, David Jeremy; Cremonesi, Matteo; Cruz Alonso, Daniel; Cuevas Maestro, Javier; Culbertson, Raymond Lloyd; D'Ascenzo, Nicola; Datta, Mousumi; de Barbaro, Pawel; Demortier, Luc M; Marchese, Luigi Marchese; Deninno, Maria Maddalena; Devoto, Francesco; D'Errico, Maria; Di Canto, Angelo; Di Ruzza, Benedetto; Dittmann, Jay Richard; D'Onofrio, Monica; Donati, Simone; Dorigo, Mirco; Driutti, Anna; Ebina, Koji; Edgar, Ryan Christopher; Erbacher, Robin D; Errede, Steven Michael; Esham, Benjamin; Farrington, Sinead Marie; Fernández Ramos, Juan Pablo; Field, Richard D; Flanagan, Gene U; Forrest, Robert David; Franklin, Melissa EB; Freeman, John Christian; Frisch, Henry J; Funakoshi, Yujiro; Galloni, Camilla; Garfinkel, Arthur F; Garosi, Paola; Gerberich, Heather Kay; Gerchtein, Elena A; Giagu, Stefano; Giakoumopoulou, Viktoria Athina; Gibson, Karen Ruth; Ginsburg, Camille Marie; Giokaris, Nikos D; Giromini, Paolo; Glagolev, Vladimir; Glenzinski, Douglas Andrew; Gold, Michael S; Goldin, Daniel; Golossanov, Alexander; Gomez, Gervasio; Gomez-Ceballos, Guillelmo; Goncharov, Maxim T; González López, Oscar; Gorelov, Igor V; Goshaw, Alfred T; Goulianos, Konstantin A; Gramellini, Elena; Grosso-Pilcher, Carla; Guimaraes da Costa, Joao; Hahn, Stephen R; Han, Ji-Yeon; Happacher, Fabio; Hara, Kazuhiko; Hare, Matthew Frederick; Harr, Robert Francis; Harrington-Taber, Timothy; Hatakeyama, Kenichi; Hays, Christopher Paul; Heinrich, Joel G; Herndon, Matthew Fairbanks; Hocker, James Andrew; Hong, Ziqing; Hopkins, Walter Howard; Hou, Suen Ray; Hughes, Richard Edward; Husemann, Ulrich; Hussein, Mohammad; Huston, Joey Walter; Introzzi, Gianluca; Iori, Maurizio; Ivanov, Andrew Gennadievich; James, Eric B; Jang, Dongwook; Jayatilaka, Bodhitha Anjalike; Jeon, Eun-Ju; Jindariani, Sergo Robert; Jones, Matthew T; Joo, Kyung Kwang; Jun, Soon Yung; Junk, Thomas R; Kambeitz, Manuel; Kamon, Teruki; Karchin, Paul Edmund; Kasmi, Azeddine; Kato, Yukihiro; Ketchum, Wesley Robert; Keung, Justin Kien; Kilminster, Benjamin John; Kim, DongHee; Kim, Hyunsoo; Kim, Jieun; Kim, Min Jeong; Kim, Soo Bong; Kim, Shin-Hong; Kim, Young-Kee; Kim, Young-Jin; Kimura, Naoki; Kirby, Michael H; Knoepfel, Kyle James; Kondo, Kunitaka; Kong, Dae Jung; Konigsberg, Jacobo; Kotwal, Ashutosh Vijay; Kreps, Michal; Kroll, IJoseph; Kruse, Mark Charles; Kuhr, Thomas; Kurata, Masakazu; Laasanen, Alvin Toivo; Lammel, Stephan; Lancaster, Mark; Lannon, Kevin Patrick; Latino, Giuseppe; Lee, Hyun Su; Lee, Jaison; Leo, Sabato; Leone, Sandra; Lewis, Jonathan D; Limosani, Antonio; Lipeles, Elliot David; Lister, Alison; Liu, Qiuguang; Liu, Tiehui Ted; Lockwitz, Sarah E; Loginov, Andrey Borisovich; Lucà, Alessandra; Lucchesi, Donatella; Lueck, Jan; Lujan, Paul Joseph; Lukens, Patrick Thomas; Lungu, Gheorghe; Lys, Jeremy E; Lysak, Roman; Madrak, Robyn Leigh; Maestro, Paolo; Malik, Sarah Alam; Manca, Giulia; Manousakis-Katsikakis, Arkadios; Margaroli, Fabrizio; Marino, Christopher Phillip; Matera, Keith; Mattson, Mark Edward; Mazzacane, Anna; Mazzanti, Paolo; McNulty, Ronan; Mehta, Andrew; Mehtala, Petteri; Mesropian, Christina; Miao, Ting; Mietlicki, David John; Mitra, Ankush; Miyake, Hideki; Moed, Shulamit; Moggi, Niccolo; Moon, Chang-Seong; Moore, Ronald Scott; Morello, Michael Joseph; Mukherjee, Aseet; Muller, Thomas; Murat, Pavel A; Mussini, Manuel; Nachtman, Jane Marie; Nagai, Yoshikazu; Naganoma, Junji; Nakano, Itsuo; Napier, Austin; Nett, Jason Michael; Nigmanov, Turgun S; Nodulman, Lawrence J; Noh, Seoyoung; Norniella Francisco, Olga; Oakes, Louise Beth; Oh, Seog Hwan; Oh, Young-do; Okusawa, Toru; Orava, Risto Olavi; Ortolan, Lorenzo; Pagliarone, Carmine Elvezio; Palencia, Jose Enrique; Palni, Prabhakar; Papadimitriou, Vaia; Parker, William Chesluk; Pauletta, Giovanni; Paulini, Manfred; Paus, Christoph Maria Ernst; Phillips, Thomas J; Piacentino, Giovanni M; Pianori, Elisabetta; Pilot, Justin Robert; Pitts, Kevin T; Plager, Charles; Pondrom, Lee G; Poprocki, Stephen; Potamianos, Karolos Jozef; Prokoshin, Fedor; Pranko, Aliaksandr Pavlovich; Ptohos, Fotios K; Punzi, Giovanni; Redondo Fernández, Ignacio; Renton, Peter B; Rescigno, Marco; Rimondi, Franco; Ristori, Luciano; Robson, Aidan; Rodriguez, Tatiana Isabel; Rolli, Simona; Ronzani, Manfredi; Roser, Robert Martin; Rosner, Jonathan L; Ruffini, Fabrizio; Ruiz Jimeno, Alberto; Russ, James S; Rusu, Vadim Liviu; Sakumoto, Willis Kazuo; Sakurai, Yuki; Santi, Lorenzo; Sato, Koji; Saveliev, Valeri; Savoy-Navarro, Aurore; Schlabach, Philip; Schmidt, Eugene E; Schwarz, Thomas A; Scodellaro, Luca; Scuri, Fabrizio; Seidel, Sally C; Seiya, Yoshihiro; Semenov, Alexei; Sforza, Federico; Shalhout, Shalhout Zaki; Shears, Tara G; Shepard, Paul F; Shimojima, Makoto; Shochet, Melvyn J; Shreyber-Tecker, Irina; Simonenko, Alexander V; Sliwa, Krzysztof Jan; Smith, John Rodgers; Snider, Frederick Douglas; Sorin, Maria Veronica; Song, Hao; Stancari, Michelle Dawn; St Denis, Richard Dante; Stentz, Dale James; Strologas, John; Sudo, Yuji; Sukhanov, Alexander I; Suslov, Igor M; Takemasa, Ken-ichi; Takeuchi, Yuji; Tang, Jian; Tecchio, Monica; Teng, Ping-Kun; Thom, Julia; Thomson, Evelyn Jean; Thukral, Vaikunth; Toback, David A; Tokar, Stanislav; Tollefson, Kirsten Anne; Tomura, Tomonobu; Tonelli, Diego; Torre, Stefano; Torretta, Donatella; Totaro, Pierluigi; Trovato, Marco; Ukegawa, Fumihiko; Uozumi, Satoru; Vázquez-Valencia, Elsa Fabiola; Velev, Gueorgui; Vellidis, Konstantinos; Vernieri, Caterina; Vidal Marono, Miguel; Vilar Cortabitarte, Rocio; Vizán Garcia, Jesus Manuel; Vogel, Marcelo; Volpi, Guido; Wagner, Peter; Wallny, Rainer S; Wang, Song-Ming; Waters, David S; Wester, William Carl; Whiteson, Daniel O; Wicklund, Arthur Barry; Wilbur, Scott; Williams, Hugh H; Wilson, Jonathan Samuel; Wilson, Peter James; Winer, Brian L; Wittich, Peter; Wolbers, Stephen A; Wolfe, Homer; Wright, Thomas Roland; Wu, Xin; Wu, Zhenbin; Yamamoto, Kazuhiro; Yamato, Daisuke; Yang, Tingjun; Yang, Un-Ki; Yang, Yu Chul; Yao, Wei-Ming; Yeh, Gong Ping; Yi, Kai; Yoh, John; Yorita, Kohei; Yoshida, Takuo; Yu, Geum Bong; Yu, Intae; Zanetti, Anna Maria; Zeng, Yu; Zhou, Chen; Zucchelli, Stefano

    2015-01-01

    We study charged particle production in proton-antiproton collisions at 300 GeV, 900 GeV, and 1.96 TeV. We use the direction of the charged particle with the largest transverse momentum in each event to define three regions of eta-phi space; toward, away, and transverse. The average number and the average scalar pT sum of charged particles in the transverse region are sensitive to the modeling of the underlying event. The transverse region is divided into a MAX and MIN transverse region, which helps separate the hard component (initial and final-state radiation) from the beam-beam remnant and multiple parton interaction components of the scattering. The center-of-mass energy dependence of the various components of the event are studied in detail. The data presented here can be used to constrain and improve QCD Monte Carlo models, resulting in more precise predictions at the LHC energies of 13 and 14 TeV.

  9. Study of the energy dependence of the underlying event in proton-antiproton collisions

    Science.gov (United States)

    Aaltonen, T.; Albrow, M.; Amerio, S.; Amidei, D.; Anastassov, A.; Annovi, A.; Antos, J.; Apollinari, G.; Appel, J. A.; Arisawa, T.; Artikov, A.; Asaadi, J.; Ashmanskas, W.; Auerbach, B.; Aurisano, A.; Azfar, F.; Badgett, W.; Bae, T.; Barbaro-Galtieri, A.; Barnes, V. E.; Barnett, B. A.; Barria, P.; Bartos, P.; Bauce, M.; Bedeschi, F.; Behari, S.; Bellettini, G.; Bellinger, J.; Benjamin, D.; Beretvas, A.; Bhatti, A.; Bland, K. R.; Blumenfeld, B.; Bocci, A.; Bodek, A.; Bortoletto, D.; Boudreau, J.; Boveia, A.; Brigliadori, L.; Bromberg, C.; Brucken, E.; Budagov, J.; Budd, H. S.; Burkett, K.; Busetto, G.; Bussey, P.; Butti, P.; Buzatu, A.; Calamba, A.; Camarda, S.; Campanelli, M.; Canelli, F.; Carls, B.; Carlsmith, D.; Carosi, R.; Carrillo, S.; Casal, B.; Casarsa, M.; Castro, A.; Catastini, P.; Cauz, D.; Cavaliere, V.; Cerri, A.; Cerrito, L.; Chen, Y. C.; Chertok, M.; Chiarelli, G.; Chlachidze, G.; Cho, K.; Chokheli, D.; Clark, A.; Clarke, C.; Convery, M. E.; Conway, J.; Corbo, M.; Cordelli, M.; Cox, C. A.; Cox, D. J.; Cremonesi, M.; Cruz, D.; Cuevas, J.; Culbertson, R.; d'Ascenzo, N.; Datta, M.; de Barbaro, P.; Demortier, L.; Deninno, M.; D'Errico, M.; Devoto, F.; Di Canto, A.; Di Ruzza, B.; Dittmann, J. R.; Donati, S.; D'Onofrio, M.; Dorigo, M.; Driutti, A.; Ebina, K.; Edgar, R.; Elagin, A.; Erbacher, R.; Errede, S.; Esham, B.; Farrington, S.; Fernández Ramos, J. P.; Field, R.; Flanagan, G.; Forrest, R.; Franklin, M.; Freeman, J. C.; Frisch, H.; Funakoshi, Y.; Galloni, C.; Garfinkel, A. F.; Garosi, P.; Gerberich, H.; Gerchtein, E.; Giagu, S.; Giakoumopoulou, V.; Gibson, K.; Ginsburg, C. M.; Giokaris, N.; Giromini, P.; Glagolev, V.; Glenzinski, D.; Gold, M.; Goldin, D.; Golossanov, A.; Gomez, G.; Gomez-Ceballos, G.; Goncharov, M.; González López, O.; Gorelov, I.; Goshaw, A. T.; Goulianos, K.; Gramellini, E.; Grosso-Pilcher, C.; Group, R. C.; Guimaraes da Costa, J.; Hahn, S. R.; Han, J. Y.; Happacher, F.; Hara, K.; Hare, M.; Harr, R. F.; Harrington-Taber, T.; Hatakeyama, K.; Hays, C.; Heinrich, J.; Herndon, M.; Hocker, A.; Hong, Z.; Hopkins, W.; Hou, S.; Hughes, R. E.; Husemann, U.; Hussein, M.; Huston, J.; Introzzi, G.; Iori, M.; Ivanov, A.; James, E.; Jang, D.; Jayatilaka, B.; Jeon, E. J.; Jindariani, S.; Jones, M.; Joo, K. K.; Jun, S. Y.; Junk, T. R.; Kambeitz, M.; Kamon, T.; Karchin, P. E.; Kasmi, A.; Kato, Y.; Ketchum, W.; Keung, J.; Kilminster, B.; Kim, D. H.; Kim, H. S.; Kim, J. E.; Kim, M. J.; Kim, S. H.; Kim, S. B.; Kim, Y. J.; Kim, Y. K.; Kimura, N.; Kirby, M.; Knoepfel, K.; Kondo, K.; Kong, D. J.; Konigsberg, J.; Kotwal, A. V.; Kreps, M.; Kroll, J.; Kruse, M.; Kuhr, T.; Kurata, M.; Laasanen, A. T.; Lammel, S.; Lancaster, M.; Lannon, K.; Latino, G.; Lee, H. S.; Lee, J. S.; Leo, S.; Leone, S.; Lewis, J. D.; Limosani, A.; Lipeles, E.; Lister, A.; Liu, H.; Liu, Q.; Liu, T.; Lockwitz, S.; Loginov, A.; Lucchesi, D.; Lucá, A.; Lueck, J.; Lujan, P.; Lukens, P.; Lungu, G.; Lys, J.; Lysak, R.; Madrak, R.; Maestro, P.; Malik, S.; Manca, G.; Manousakis-Katsikakis, A.; Marchese, L.; Margaroli, F.; Marino, P.; Matera, K.; Mattson, M. E.; Mazzacane, A.; Mazzanti, P.; McNulty, R.; Mehta, A.; Mehtala, P.; Mesropian, C.; Miao, T.; Mietlicki, D.; Mitra, A.; Miyake, H.; Moed, S.; Moggi, N.; Moon, C. S.; Moore, R.; Morello, M. J.; Mukherjee, A.; Muller, Th.; Murat, P.; Mussini, M.; Nachtman, J.; Nagai, Y.; Naganoma, J.; Nakano, I.; Napier, A.; Nett, J.; Neu, C.; Nigmanov, T.; Nodulman, L.; Noh, S. Y.; Norniella, O.; Oakes, L.; Oh, S. H.; Oh, Y. D.; Oksuzian, I.; Okusawa, T.; Orava, R.; Ortolan, L.; Pagliarone, C.; Palencia, E.; Palni, P.; Papadimitriou, V.; Parker, W.; Pauletta, G.; Paulini, M.; Paus, C.; Phillips, T. J.; Piacentino, G.; Pianori, E.; Pilot, J.; Pitts, K.; Plager, C.; Pondrom, L.; Poprocki, S.; Potamianos, K.; Pranko, A.; Prokoshin, F.; Ptohos, F.; Punzi, G.; Redondo Fernández, I.; Renton, P.; Rescigno, M.; Rimondi, F.; Ristori, L.; Robson, A.; Rodriguez, T.; Rolli, S.; Ronzani, M.; Roser, R.; Rosner, J. L.; Ruffini, F.; Ruiz, A.; Russ, J.; Rusu, V.; Sakumoto, W. K.; Sakurai, Y.; Santi, L.; Sato, K.; Saveliev, V.; Savoy-Navarro, A.; Schlabach, P.; Schmidt, E. E.; Schwarz, T.; Scodellaro, L.; Scuri, F.; Seidel, S.; Seiya, Y.; Semenov, A.; Sforza, F.; Shalhout, S. Z.; Shears, T.; Shepard, P. F.; Shimojima, M.; Shochet, M.; Shreyber-Tecker, I.; Simonenko, A.; Sliwa, K.; Smith, J. R.; Snider, F. D.; Song, H.; Sorin, V.; St. Denis, R.; Stancari, M.; Stentz, D.; Strologas, J.; Sudo, Y.; Sukhanov, A.; Suslov, I.; Takemasa, K.; Takeuchi, Y.; Tang, J.; Tecchio, M.; Teng, P. K.; Thom, J.; Thomson, E.; Thukral, V.; Toback, D.; Tokar, S.; Tollefson, K.; Tomura, T.; Tonelli, D.; Torre, S.; Torretta, D.; Totaro, P.; Trovato, M.; Ukegawa, F.; Uozumi, S.; Vázquez, F.; Velev, G.; Vellidis, C.; Vernieri, C.; Vidal, M.; Vilar, R.; Vizán, J.; Vogel, M.; Volpi, G.; Wagner, P.; Wallny, R.; Wang, S. M.; Waters, D.; Wester, W. C.; Whiteson, D.; Wicklund, A. B.; Wilbur, S.; Williams, H. H.; Wilson, J. S.; Wilson, P.; Winer, B. L.; Wittich, P.; Wolbers, S.; Wolfe, H.; Wright, T.; Wu, X.; Wu, Z.; Yamamoto, K.; Yamato, D.; Yang, T.; Yang, U. K.; Yang, Y. C.; Yao, W.-M.; Yeh, G. P.; Yi, K.; Yoh, J.; Yorita, K.; Yoshida, T.; Yu, G. B.; Yu, I.; Zanetti, A. M.; Zeng, Y.; Zhou, C.; Zucchelli, S.; CDF Collaboration

    2015-11-01

    We study charged particle production (pT>0.5 GeV /c , |η |<0.8 ) in proton-antiproton collisions at total center-of-mass energies √{s }=300 GeV , 900 GeV, and 1.96 TeV. We use the direction of the charged particle with the largest transverse momentum in each event to define three regions of η -ϕ space: "toward", "away", and "transverse." The average number and the average scalar pT sum of charged particles in the transverse region are sensitive to the modeling of the "underlying event." The transverse region is divided into a MAX and MIN transverse region, which helps separate the "hard component" (initial and final-state radiation) from the "beam-beam remnant" and multiple parton interaction components of the scattering. The center-of-mass energy dependence of the various components of the event is studied in detail. The data presented here can be used to constrain and improve QCD Monte Carlo models, resulting in more precise predictions at the LHC energies of 13 and 14 TeV.

  10. Bottom Quark-antiquark Production And Mixing In Proton- Antiproton Collisions

    CERN Document Server

    Yu, Z

    2003-01-01

    The studies of bottom quark-antiquark production in proton-antiproton collisions play an important role in testing perturbative QCD. Measuring the mixing parameter of B mesons imposes constraints on the quark mixing (CKM) matrix and enhances the understanding of the Standard Model. Multi-GeV pp¯ colliders produce a significant amount of bb¯ pairs and thus enable studies in both of these fields. This thesis presents results of the bb¯ production cross section from pp¯ collisions at s = 1.8 TeV and the time-integrated average BB¯ mixing parameter &parl0;c&parr0; using high- mass dimuon data collected by CDF during its Run IB. There is a high concentration of muon pairs from inclusive semileptonic B decays in this data set. We take advantage of the long lifetime property of B hadrons and isolate the muons from B decays by studying the displacement of the muon pair trajectories. We use an Unbinned Maximum Likelihood Fitting method to fit the two dimensi...

  11. Antihyperon-hyperon production in antiproton-proton annihilations with PANDA at FAIR

    Energy Technology Data Exchange (ETDEWEB)

    Papenbrock, Michael [Department of Nuclear Physics and Astronomy, Uppsala University, Uppsala (Sweden); Collaboration: PANDA-Collaboration

    2015-07-01

    The production of antihyperon-hyperon pairs in antiproton-proton annihilations involves the annihilation of at least one light (u,d) quark-antiquark pair and the creation of a heavier (s,c,b) pair. Production of strange hyperons occur in an energy region in which QCD is difficult to predict. By studying hyperon production we learn about the strong interaction in this energy region, i.e. the confinement domain. It is an open question what the relevant degrees of freedom are: quarks and gluons, or hadrons. Spin observables is an excellent tool in order to better understand the physical processes. These are accessible via the weak, parity violating decay of the hyperon which results in an angular asymmetry of the decay products. The future PANDA experiment at FAIR is going to be ideally suited to study spin physics on hyperons with both high precision and high statistics. Since hyperons decay weakly and thus have long life-times, their decay vertices are displaced with respect to the production point. This sets high demands on precise track reconstruction. A pattern recognition algorithm is currently under development, with the ability to reconstruct tracks originating in displaced vertices. Simulation studies done by the Uppsala group as well as the status of the development will be presented and discussed.

  12. Formation spectra of charmed meson--nucleus systems using an antiproton beam

    CERN Document Server

    Yamagata-Sekihara, J; Nieves, J; Salcedo, L L; Tolos, L

    2015-01-01

    We investigate the structure and formation of charmed meson--nucleus systems, with the aim of understanding the charmed meson--nucleon interactions and the properties of the charmed mesons in the nuclear medium. The $\\bar{D}$ mesic nuclei are of special interest, since they have tiny decay widths due to the absence of strong decays for the $\\bar{D} N$ pair. Employing an effective model for the $\\bar{D} N$ and $D N$ interactions and solving the Klein--Gordon equation for $\\bar{D}$ and $D$ in finite nuclei, we find that the $D^{-}$-${}^{11}\\rm{B}$ system has $1 s$ and $2p$ mesic nuclear states and that the $D^{0}$-${}^{11}\\rm{B}$ system binds in a $1s$ state. In view of the forthcoming experiments by the PANDA and CBM Collaborations at the future FAIR facility and the J-PARC upgrade, we calculate the formation spectra of the $[D^{-}$-${}^{11}\\rm{B}]$ and $[D^{0}$-${}^{11}\\rm{B}]$ mesic nuclei for an antiproton beam on a ${}^{12} \\rm{C}$ target. Our results suggest that it is possible to observe the $2 p$ $D^{-}...

  13. Exclusive Central $\\pi^{+}\\pi^{-}$ Production in Proton Antiproton Collisions at the CDF

    Energy Technology Data Exchange (ETDEWEB)

    Zurek, Maria [Julich, Forschungszentrum

    2015-01-01

    Exclusive $\\pi^{=}\\pi^{-}$ production in proton-antiproton collisions at $\\sqrt{s}$ = 0.9 and 1.96 TeV in the Collider Detector at Fermilab has been measured. We select events with two particles with opposite charge in pseudorapidity region -1.3 < $\\eta$ < 1.3 with no other particles detected in -5.9 < $\\eta$ < 5.9. Particles are assumed to be pions. The $\\pi^{+}\\pi^{-}$system is required to have rapidity -1.0 < $y$ < 1.0. The data are expected to be dominated by the double pomeron exchange mechanism. Therefore, the quantum numbers of the central state are constrained. The data extend up to dipion mass M($\\pi^{+}\\pi^{-}$) = 5000 MeV/$c^2$. Resonance structures consistent with $f_0$ and $f_2$(1270) mesons are visible. The results are valuable for light hadron spectroscopy and for providing information about the nature of the pomeron in a region between non-perturbative and perturbative quantum chromodynamics

  14. Ultrahigh Energy Cosmic Rays, The Diffuse High Energy Gamma Ray Background and Anti-protons

    CERN Document Server

    Eichler, David; Gavish, Eyal

    2016-01-01

    Theories for the origin of ultrahigh energy cosmic rays (UHECR) may imply a significant diffuse background in secondary $\\gamma$-rays from the pair cascads the UHECR initiate when interacting with background light. It is shown that, because the spectrum of these secondary $\\gamma$-rays is softer than the measured diffuse $\\gamma$-ray background in the 10-1000 GeV range, the addition of a hard component from the decay of TeV dark matter particles, subject to the implied constraints on its parameters, improves the fit. It is further argued that any compact astrophysical source of $\\bar p$s is unlikely to be as strong as decay of TeV dark matter particles, given bounds set by neutrino observations. The diffuse $\\gamma$-ray background presently sets the strongest lower bound on the lifetime of TeV dark matter particles, and hence on attendant anti-proton production, and further identification of other contributors to this background will further tighten these constraints.

  15. Antiproton constraints on the GeV gamma-ray excess: a comprehensive analysis

    CERN Document Server

    Cirelli, Marco; Giesen, Gaëlle; Taoso, Marco; Urbano, Alfredo

    2014-01-01

    A GeV gamma-ray excess has possibly been individuated in Fermi-LAT data from the Galactic Center and interpreted in terms of Dark Matter (DM) annihilations, either in hadronic (essentially $b\\bar{b}$) or leptonic channels. In order to test this tantalizing interpretation, we address two issues: (i) we improve the computation of secondary emission from DM (Inverse Compton and Bremsstrahlung) with respect to previous works, confirming it to be very relevant for determining the DM spectrum in the leptonic channels, so that any conclusion on the DM nature of the signal critically depends on this contribution; (ii) we consider the constraints from antiprotons on the DM hadronic channel, finding that the uncertainties on the propagation model, and in particular on the halo height, play a major role. Moreover, we discuss the role of solar modulation, taking into account possible charge dependent effects whose importance is estimated exploiting detailed numerical tools. The limits that we obtain severely constrain th...

  16. Antiproton constraints on the GeV gamma-ray excess: a comprehensive analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cirelli, Marco; Giesen, Gaëlle; Taoso, Marco [Institut de Physique Théorique, CNRS URA2306 and CEA-Saclay, 91191 Gif-sur-Yvette (France); Gaggero, Daniele; Urbano, Alfredo, E-mail: marco.cirelli@cea.fr, E-mail: daniele.gaggero@sissa.it, E-mail: gaelle.giesen@cea.fr, E-mail: marco.taoso@cea.fr, E-mail: alfredo.urbano@sissa.it [SISSA, via Bonomea 265, 34136 Trieste (Italy)

    2014-12-01

    A GeV gamma-ray excess has possibly been individuated in Fermi-LAT data from the Galactic Center and interpreted in terms of Dark Matter (DM) annihilations, either in hadronic (essentially b b-bar ) or leptonic channels. In order to test this tantalizing interpretation, we address two issues: (i) we improve the computation of secondary emission from DM (Inverse Compton and Bremsstrahlung) with respect to previous works, confirming it to be very relevant for determining the DM spectrum in the leptonic channels, so that any conclusion on the DM nature of the signal critically depends on this contribution; (ii) we consider the constraints from antiprotons on the DM hadronic channel, finding that the uncertainties on the propagation model, and in particular on the halo height, play a major role. Moreover, we discuss the role of solar modulation, taking into account possible charge dependent effects whose importance is estimated exploiting detailed numerical tools. The limits that we obtain severely constrain the DM interpretation of the excess in the hadronic channel, for standard assumptions on the Galactic propagation parameters and solar modulation. However, they considerably relax if more conservative choices are adopted.

  17. Fibre Optic Notch Filter For The Antiproton Decelerator Stochastic Cooling System

    CERN Document Server

    Simmonds, Max Vincent John

    2016-01-01

    The project scope included reverse engineering, upgrading, and recovering the operational conditions of an existing fibre optic notch filter. Once operational, tests were to be preformed to confirm the performance of the temperature stabilisation. The end goal is to use said notch filter in the Antiproton Decelerator (AD) facility at CERN to help aid antimatter research. The notch filter was successfully reverse engineered and then documented. Changes were made in order to increase performance and reliability, and also allow easy integration into the AD. An additional phase was added whereby the notch filter was to be controller via a touchscreen computer, situated next to the filter, allowing engineers to set-up each of the electronic devices used. While one of the devices (Motorised Delay Line) can be controlled by the touchscreen computer, the other two cannot.Due to time constraints and difficulties with the Beckhoff TwincatII programming language, the USB devices were not able to be controlled via the To...

  18. High-precision comparison of the antiproton-to-proton charge-to-mass ratio

    CERN Document Server

    Ulmer, S; Mooser, A; Franke, K; Nagahama, H; Schneider, G; Higuchi, T; Van Gorp, S; Blaum, K; Matsuda, Y; Quint, W; Walz, J; Yamazaki, Y

    2015-01-01

    Invariance under the charge, parity, time-reversal (CPT) transformation$^{1}$ is one of the fundamental symmetries of the standard model of particle physics. This CPT invariance implies that the fundamental properties of antiparticles and their matter-conjugates are identical, apart from signs. There is a deep link between CPT invariance and Lorentz symmetry—that is, the laws of nature seem to be invariant under the symmetry transformation of spacetime—although it is model dependent$^{2}$. A number of high-precision CPT and Lorentz invariance tests—using a co-magnetometer, a torsion pendulum and a maser, among others—have been performed$^{3}$, but only a few direct high-precision CPT tests that compare the fundamental properties of matter and antimatter are available$^{4, 5, 6, 7, 8}$. Here we report high-precision cyclotron frequency comparisons of a single antiproton and a negatively charged hydrogen ion (H$^−$) carried out in a Penning trap system. From 13,000 frequency measurements we compare th...

  19. Search For Electroweak Single Top Quark Production In 1.96 Tev Proton-antiproton Collisions

    CERN Document Server

    Stelzer, B

    2005-01-01

    This thesis describes the first search for electroweak single top quark production in proton-antiproton collisions at a center of mass energy of 1.96 TeV. The data sample used for this analysis corresponds to 162 pb -1 recorded by the upgraded Collider Detector at Fermilab. The search is performed by doing a classic maximum likelihood fit to the H T distribution in data. The kinematic variable H T is the scalar sum of transverse energies of all final state particles in the event. This variable has the advantage that its distribution looks very similar for both contributing (s- channel and t-channel) single top processes, but is different for background processes. The combination of both channels to one signal improves the sensitivity of the search. No significant evidence for electroweak single top quark production is found and we set an upper limit at the 95% confidence level on the combined single top quark production cross section of 17.8 pb.

  20. Bayesian analysis of spatial-dependent cosmic-ray propagation: astrophysical background of antiprotons and positrons

    CERN Document Server

    Feng, Jie; Oliva, Alberto

    2016-01-01

    The AMS-02 experiment has reported a new measurement of the antiproton/proton ratio in Galactic cosmic rays (CRs). In the energy range $E\\sim\\,$60-450 GeV, this ratio is found to be remarkably constant. Using recent data on CR proton, helium, carbon, 10Be/9Be, and B/C ratio, we have performed a global Bayesian analysis based on a Markov-Chain Monte-Carlo sampling algorithm under a "two halo model" of CR propagation. In this model, CRs are allowed to experience a different type of diffusion when they propagate in the region close of the Galactic disk. We found that the vertical extent of this region is about 900 pc above and below the disk, and the corresponding diffusion coefficient scales with energy as $D\\sim\\,E^{0.15}$, describing well the observations on primary CR spectra, secondary/primary ratios and anisotropy. Under this model we have carried out improved calculations of antiparticle spectra arising from secondary CR production and their corresponding uncertainties. We made use of Monte-Carlo generato...

  1. Study of the energy dependence of the underlying event in proton-antiproton collisions

    Energy Technology Data Exchange (ETDEWEB)

    Nodulman, L.; Aaltonen, T; Albrow, M; Amerio, S.; Amidei, D; Anastassov, A.; Annovi, A; Antos, J; Apollinari, G.; Appel, J A; Arisawa, T

    2015-11-23

    We study charged particle production (p(T) > 0.5 GeV/c, vertical bar eta vertical bar < 0.8) in proton-antiproton collisions at total center-of-mass energies root s = 300 GeV, 900 GeV, and 1.96 TeV. We use the direction of the charged particle with the largest transverse momentum in each event to define three regions of eta - phi space: "toward", "away", and "transverse." The average number and the average scalar pT sum of charged particles in the transverse region are sensitive to the modeling of the "underlying event." The transverse region is divided into a MAX and MIN transverse region, which helps separate the "hard component" (initial and final-state radiation) from the "beam-beam remnant" and multiple parton interaction components of the scattering. The center-of-mass energy dependence of the various components of the event is studied in detail. The data presented here can be used to constrain and improve QCD Monte Carlo models, resulting in more precise predictions at the LHC energies of 13 and 14 TeV.

  2. Malaria-associated peripheral gangrene

    Directory of Open Access Journals (Sweden)

    Deborah B. Martins

    2014-09-01

    Full Text Available Malaria is a common parasitic disease endemic in tropical and subtropical areas, including Mozambique. Symmetrical peripheral gangrene is a rare complication of malaria. The purpose of this study was to review cases of malaria-associated peripheral gangrene that were evaluated by the pediatric surgical service at Hospital Central. Four patients ranging in age from 11 months to 7 years with documented Plasmodium falciparum infection and peripheral gangrene were identified. Amputation was required in cases of wet-gangrene. The majority of cases were allowed to self-demarcate, and one was allowed to auto-amputate.

  3. Radiotherapy Treatment Planning for Testicular Seminoma

    Energy Technology Data Exchange (ETDEWEB)

    Wilder, Richard B., E-mail: richardbwilder@yahoo.com [Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL (United States); Buyyounouski, Mark K. [Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Efstathiou, Jason A. [Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States); Beard, Clair J. [Department of Radiation Oncology, Dana-Farber/Brigham and Women' s Cancer Center, Boston, MA (United States)

    2012-07-15

    Virtually all patients with Stage I testicular seminoma are cured regardless of postorchiectomy management. For patients treated with adjuvant radiotherapy, late toxicity is a major concern. However, toxicity may be limited by radiotherapy techniques that minimize radiation exposure of healthy normal tissues. This article is an evidence-based review that provides radiotherapy treatment planning recommendations for testicular seminoma. The minority of Stage I patients who choose adjuvant treatment over surveillance may be considered for (1) para-aortic irradiation to 20 Gy in 10 fractions, or (2) carboplatin chemotherapy consisting of area under the curve, AUC = 7 Multiplication-Sign 1-2 cycles. Two-dimensional radiotherapy based on bony anatomy is a simple and effective treatment for Stage IIA or IIB testicular seminoma. Centers with expertise in vascular and nodal anatomy may consider use of anteroposterior-posteroanterior fields based on three-dimensional conformal radiotherapy instead. For modified dog-leg fields delivering 20 Gy in 10 fractions, clinical studies support placement of the inferior border at the top of the acetabulum. Clinical and nodal mapping studies support placement of the superior border of all radiotherapy fields at the top of the T12 vertebral body. For Stage IIA and IIB patients, an anteroposterior-posteroanterior boost is then delivered to the adenopathy with a 2-cm margin to the block edge. The boost dose consists of 10 Gy in 5 fractions for Stage IIA and 16 Gy in 8 fractions for Stage IIB. Alternatively, bleomycin, etoposide, and cisplatin chemotherapy for 3 cycles or etoposide and cisplatin chemotherapy for 4 cycles may be delivered to Stage IIA or IIB patients (e.g., if they have a horseshoe kidney, inflammatory bowel disease, or a history of radiotherapy).

  4. Post Pelvic Radiotherapy Bony Changes

    Energy Technology Data Exchange (ETDEWEB)

    Huh, Seung Jae [Samsung Medical Center, Seoul (Korea, Republic of)

    2009-03-15

    There has been recent interest in radiation-induced bone injury in clinical conditions, especially for pelvic insufficiency fracture (PIF). A PIF is caused by the effect of normal or physiological stress on bone with demineralization and decreased elastic resistance. Pelvic radiotherapy (RT) can also contribute to the development of a PIF. A PIF has been regarded as a rare complication with the use of megavoltage equipment. However, recent studies have reported the incidence of PIFs as 8.2{approx}20% after pelvic RT in gynecological patients, an incidence that was higher than previously believed. The importance of understanding a PIF lies in the potential for misdiagnosis as a bony metastasis. If patients complain of pelvic pain after whole-pelvis radiation therapy, the presence of a PIF must be considered in the differential diagnosis. The use of multibeam arrangements and conformal RT to reduce the volume and dose of irradiated pelvic bone can be helpful to minimize the risk of fracture. In addition to a PIF, osteonecrosis and avascular necrosis of the femoral head can develop after radiation therapy. Osteoradionecrosis of the pelvic bone is a clinical diagnostic challenge that must be differentiated from an osseous metastasis. A post-radiation bone sarcoma can result as a long-term sequela of pelvic irradiation for uterine cervical cancer.

  5. Peripheral neuropathy in mitochondrial disorders.

    Science.gov (United States)

    Pareyson, Davide; Piscosquito, Giuseppe; Moroni, Isabella; Salsano, Ettore; Zeviani, Massimo

    2013-10-01

    Why is peripheral neuropathy common but mild in many mitochondrial disorders, and why is it, in some cases, the predominant or only manifestation? Although this question remains largely unanswered, recent advances in cellular and molecular biology have begun to clarify the importance of mitochondrial functioning and distribution in the peripheral nerve. Mutations in proteins involved in mitochondrial dynamics (ie, fusion and fission) frequently result in a Charcot-Marie-Tooth phenotype. Peripheral neuropathies with different phenotypic presentations occur in mitochondrial diseases associated with abnormalities in mitochondrial DNA replication and maintenance, or associated with defects in mitochondrial respiratory chain complex V. Our knowledge of mitochondrial disorders is rapidly growing as new nuclear genes are identified and new phenotypes described. Early diagnosis of mitochondrial disorders, essential to provide appropriate genetic counselling, has become crucial in a few treatable conditions. Recognising and diagnosing an underlying mitochondrial defect in patients presenting with peripheral neuropathy is therefore of paramount importance.

  6. Mitochondrial dynamics and peripheral neuropathy.

    Science.gov (United States)

    Baloh, Robert H

    2008-02-01

    Peripheral neuropathy is perhaps the archetypal disease of axonal degeneration, characteristically involving degeneration of the longest axons in the body. Evidence from both inherited and acquired forms of peripheral neuropathy strongly supports that the primary pathology is in the axons themselves and points to disruption of axonal transport as an important disease mechanism. Recent studies in human genetics have further identified abnormalities in mitochondrial dynamics--the fusion, fission, and movement of mitochondria--as a player in the pathogenesis of inherited peripheral neuropathy. This review provides an update on the mechanisms of mitochondrial trafficking in axons and the emerging relationship between the disruption of mitochondrial dynamics and axonal degeneration. Evidence suggests mitochondria are a "critical cargo" whose transport is necessary for proper axonal and synaptic function. Importantly, understanding the regulation of mitochondrial movement and the consequences of decreased axonal mitochondrial function may define new paths for therapeutic agents in peripheral neuropathy and other neurodegenerative diseases.

  7. Peripheral Artery Disease and Diabetes

    Science.gov (United States)

    ... Venous Thromboembolism Aortic Aneurysm More Peripheral Artery Disease & Diabetes Updated:Jan 26,2016 People with diabetes are ... life. This content was last reviewed January 2016. Diabetes • Home • About Diabetes • Why Diabetes Matters Introduction Cardiovascular ...

  8. Multiplicity dependence of charged pion, kaon, and (antiproton production at large transverse momentum in p–Pb collisions at sNN=5.02 TeV

    Directory of Open Access Journals (Sweden)

    J. Adam

    2016-09-01

    At intermediate pT the (antiproton RpPb shows a Cronin-like enhancement, while pions and kaons show little or no nuclear modification. At high pT the charged pion, kaon and (antiproton RpPb are consistent with unity within statistical and systematic uncertainties.

  9. Track structure modelling for ion radiotherapy

    CERN Document Server

    Korcyl, Marta

    2014-01-01

    In its broadest terms, doctoral dissertation entitled "Track structure modelling for ion radiotherapy" is part of the supporting research background in the development of the ambitious proton radiotherapy project currently under way at the Institute of Nuclear Physics PAN in Krak\\'ow. Another broad motivation was the desire to become directly involved in research on a topical and challenging subject of possibly developing a therapy planning system for carbon beam radiotherapy, based in its radiobiological part on the Track Structure model developed by prof. Robert Katz over 50 years ago. Thus, the general aim of this work was, firstly, to recapitulate the Track Structure model and to propose an updated and complete formulation of this model by incorporating advances made by several authors who had contributed to its development in the past. Secondly, the updated and amended (if necessary) formulation of the model was presented in a form applicable for use in computer codes which would constitute the "radiobio...

  10. Growth Laws in Cancer: Implications for Radiotherapy

    CERN Document Server

    Castorina, P; Gabriele, P; Guiot, C

    2006-01-01

    Comparing both, the more conventional Gompertz tumor growth law (GL) and the ``Universal'' law (UL), recently proposed and applied to cancer,we have investigated the growth law's implications on various radiotherapy regimen. According to GL, the surviving tumor cell fraction could be reduced 'ad libidum', independently of the initial tumor mass,simply by increasing the number of treatments. On the contrary, if tumor growth dynamics would indeed follow the Universal scaling law, there is a lower limit of the survival fraction that cannot be reduced any further regardless of the total number of treatments. This finding can explain the so called ``tumor size effect'' and re-emphasizes the importance of early diagnosis as it implies that radiotherapy may be successful provided the tumor mass at treatment onset is rather small. Taken together with our previous works, implications of these findings include revisiting standard radiotherapy regimen and overall treatment protocols.

  11. [Radiotherapy of choroid metastases in breast carcinoma].

    Science.gov (United States)

    Dobrowsky, W; Schmid, A P; Dobrowsky, E

    1987-06-01

    From 1975 to 1984, thirteen patients were submitted to radiotherapy for choroid metastases of mammary carcinoma. Bilateral manifestation was found in three cases, thus sixteen eyes have been treated. All irradiations were performed with high voltage equipment. The posterior section of the eye was irradiated with 25 to 50 Gy over 2.5 to 5 weeks. Complete regression was achieved in nine out of sixteen cases, five patients showed an improvement of at least 50%, no considerable effect was found in two cases. The survival is 4 to 48 months (median survival 20 months) from the beginning of radiotherapy. Radiotherapy is a quick, efficient, and sparing treatment in choroid metastases. If applied in due time, it can prevent a visual disorder or amaurosis, thus improving the patients' quality of life.

  12. Radiotherapy-induced hypopituitarism: a review.

    Science.gov (United States)

    Sathyapalan, Thozhukat; Dixit, Sanjay

    2012-05-01

    Hypopituitarism is a disorder caused by impaired hormonal secretions from the hypothalamic-pituitary axis. Radiotherapy is the most common cause of iatrogenic hypopituitarism. The hypothalamic-pituitary axis inadvertently gets irradiated in patients receiving prophylactic cranial radiotherapy for leukemia, total body irradiation and radiotherapy for intracranial, base skull, sinonasal and nasopharyngeal tumors. Radiation-induced hypopituitarism (RIH) is insidious, progressive and largely nonreversible. Mostly, RIH involves one hypothalamic-pituitary axis; however, multiple hormonal axes deficiency starts developing at higher doses. Although the clinical effects of the hypopituitarism are more profound in children and young adults, its implications in older adults are being increasingly recognized. The risk continues to persist or increase up to 10 years following radiation exposure. The clinical management of hypopituitarism is challenging both for the patients and healthcare providers. Here we have reviewed the scale of the problem, the risk factors and the management of RIH.

  13. Pelvic radiotherapy and sexual dysfunction in women

    DEFF Research Database (Denmark)

    Jensen, Pernille Tine; Froeding, Ligita Paskeviciute

    2015-01-01

    of life (QOL) issues; sexual functioning has proved to be one of the most important aspects of concern in long-term survivors. METHODS: An updated literature search in PubMed was performed on pelvic radiotherapy and female sexual functioning/dysfunction. Studies on gynaecological, urological...... and gastrointestinal cancers were included. The focus was on the period from 2010 to 2014, on studies using PROs, on potential randomized controlled trials (RCTs) where female sexual dysfunction (FSD) at least constituted a secondary outcome, and on studies reporting from modern radiotherapy modalities. RESULTS...... during the next five years. Several newer studies confirm that health care professionals are still reluctant to discuss treatment induced sexual dysfunction with patients. CONCLUSIONS: Pelvic radiotherapy has a persistent deteriorating effect on the vaginal mucosa impacting negatively on the sexual...

  14. Prevention and treatment of the orofacial complications of radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Rothwell, B.R.

    1987-03-01

    Radiotherapy of malignant head and neck tumors often causes extensive, permanent changes in salivary glands, peridental alveolar bone, and mucosal structures. Dental neglect and inappropriate dental management can cause complications. The potential orofacial side effects of radiotherapy are reviewed, as are preventive strategies for the dental treatment of patients scheduled to undergo radiotherapy.

  15. Conformal radiotherapy of prostate carcinoma: Procedure description

    Directory of Open Access Journals (Sweden)

    Erak Marko

    2011-01-01

    Full Text Available Introduction. Today, three-dimensional conformal radiotherapy is a standard way in the radical treatment of localized prostate cancer, and it is an alternative to the radical prostatectomy. This method of radiotherapy treatment is widely accepted in the treatment of prostate cancer patients, and provides irradiation of targeted volume (prostate, seminal vesicles with dose escalation sparing the surrounding healthy tissues (rectum, bladder at the same time. That is not possible with the conventional twodimension technique. Procedure description. Three-dimensional conformal radiotherapy is a volumetric, visual simulation according to the computed tomography slices; it defines the tumour and organ at risk individually in each patient. Results of several studies have shown that there is a significant decrease in the development of acute toxicity when prostate cancer patients are treated with conformal radiotherapy. High dose irradiation gives excellent results in treatment of localized prostate carcinoma and improves treatment results in the patients with locally advanced carcinoma of prostate. Discussion. Prostate carcinoma irradiation techniques have been changed dramatically during recent years. Data obtained by computed tomography are important since the size and shapes of the prostate as well as its anatomic relations towards the rectum and bladder are considerably different in individual patients. The three-dimension plan of irradiation can be designed for each patient individually by performing computed tomography technique when planning radiotherapy. Conclusion. The advanced planning systems for conformal radiotherapy can reconstruct the anatomic structures of pelvis in three-dimension technique on the basis of computed tomography scans, which provides better conformality between the irradiation beam and geometrical shape of the tumour with minimal irradiation of the surrounding healthy tissue.

  16. Radiotherapy in the management of Graves` ophthalmopathy

    Energy Technology Data Exchange (ETDEWEB)

    Sakata, Koh-ichi; Hareyama, Masato; Oouchi, Atsushi; Shidou, Mitsuo; Nagakura, Hisayasu; Morita, Kazuo; Osanai, Hajime; Ohtsuka, Kenji; Hinoda, Yuji [Sapporo Medical Univ. (Japan). School of Medicine

    1998-06-01

    To report the results of radiotherapy for patients with failure, adverse reactions or relative contraindications to the use of steroids or immunosuppressants, by using newly developed quantitative indexes. Fourteen female and six male patients with Graves` ophthalmopathy were treated with radiotherapy between 1989 and 1996. Prior to radiotherapy, eight patients received treatment with prednisone, four received immunosuppressants and four received a combination of both. Four patients with contraindications to steroids were initially managed with radiotherapy. Most of the patients received a dose of 24-28 Gy in 2 Gy fractions. We used the newly developed motility limitation index to assess extraocular motility. Treatment was well tolerated. There have been no late complications. All 12 patients with soft tissue signs such as edema, irritation, tearing and pain were improved. Proptosis did not improve or improved only slightly, 3 mm at best. However, proptosis in all but two has been stabilized and has not deteriorated in the follow-up period. Most of the patients have experienced an improvement of eye-muscle motility. Extraocular muscles that work for elevation were impaired more severely than the other muscles and this tended to remain. Of the 16 patients using steroids before or when radiotherapy was initiated, 15 were tapered off and only one patient required additional steroids, thus sparing the majority from steroid adverse reactions. Radiotherapy was effective in preventing exacerbations of active inflammatory ophthalmopathy in patients with Graves` disease with minimal morbidity and thus eliminated the adverse reactions associated with protracted corticosteroid use. The newly developed motility limitation index was useful in detecting delicate changes in motility of individual extraocular muscles. (author)

  17. Inter-observer delineation uncertainty in radiotherapy of peripheral lung tumours

    DEFF Research Database (Denmark)

    Persson, Gitte Fredberg; Nygaard, Ditte Eklund; Roed, Anders Peter

    was included in the study. In our clinical protocol the contrast enhanced PET/CT scan is primarily analysed by a specialist in nuclear medicine and a radiologists together. The PET positive volume is delineated by the specialist in nuclear medicine and only the CT scan and this contour is imported to Eclipse...

  18. Radiotherapy versus combined modality in early stages

    DEFF Research Database (Denmark)

    Specht, L; Carde, P; Mauch, P;

    1992-01-01

    In early stage Hodgkin's disease the optimal choice of treatment for the individual patient is still an unresolved issue. So far, twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out worldwide. The preliminary results of a global...... be kept at a minimum. Recently, trials have been carried out testing chemotherapy alone. The results of these trials are however conflicting. In order not to jeopardize the good results achieved with the standard treatments developed over the last three decades, newer treatment approaches should...... be carefully tested in large randomized trials before being implemented for general clinical use....

  19. Second Study of Hyper-Fractionated Radiotherapy

    Directory of Open Access Journals (Sweden)

    R. Jacob

    1999-01-01

    Full Text Available Purpose and Method. Hyper-fractionated radiotherapy for treatment of soft tissue sarcomas is designed to deliver a higher total dose of radiation without an increase in late normal tissue damage. In a previous study at the Royal Marsden Hospital, a total dose of 75 Gy using twice daily 1.25 Gy fractions resulted in a higher incidence of late damage than conventional radiotherapy using 2 Gy daily fractions treating to a total of 60 Gy. The current trial therefore used a lower dose per fraction of 1.2 Gy and lower total dose of 72 Gy, with 60 fractions given over a period of 6 weeks.

  20. Late effects on human bone marrow after extended field radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Parmentier, C.; Morardet, N.; Tubiana, M.

    1983-09-01

    Thirty-two patients with lymphoma were treated by extended radiotherapy (RT) at a dose of 40 Gy and were studied by ferrokinetic studies and surface counting at various times following irradiation. Loss of hematopoietic activity in the irradiated areas is compensated by increased activity in the non-irradiated areas. Despite the return of peripheral blood counts to normal, the hyperactivity of the non-irradiated bone marrow persists over up to 13 years after RT, while the hematopoietic activity of the irradiated areas remains depressed and is only slightly higher than immediately after RT. The hypoactivity persisted even when the hemopoietic tissues had been subjected to the intense stimulation provoked by an aplasia caused by chemotherapy. However, a recovery was observed for dose of 20 Gy or lower. The hemopoietic activity of the irradiated bone marrow appears to be related to the volume of the marrow irradiated and is higher after a mantle + inverted Y field than after a mantle field. Bone marrow scintigraphies with /sup 59/Fe in 7 out of 9 patients studied revealed an extension of hematopoiesis into a normally dormant area of the marrow, such as the femora. In 2 patients an erythropoietic activity was observed in spleens which had received a dose of 40 Gy, and extra medullary erythropoiesis was found in approximately two-thirds of the patients.

  1. Thermalization of dense hadronic matter in Au + Au collisions at energies available at the Facility for Antiproton and Ion Research

    Science.gov (United States)

    De, Somnath; De, Sudipan; Chattopadhyay, Subhasis

    2016-11-01

    The conditions of local thermodynamic equilibrium of baryons (nonstrange, strange) and mesons (strange) are presented for central Au + Au collisions at Facility for Antiproton and Ion Research (FAIR) energies using the microscopic transport model UrQMD. The net particle density, longitudinal-to-transverse pressure anisotropy, and inverse slope parameters of the energy spectra of nonstrange and strange hadrons are calculated inside a cell in the central region within rapidity window |y |evolution of the entropy densities at FAIR energies are found to be very similar to the ideal hydrodynamic behavior at top Relativistic Heavy Ion Collider (RHIC) energy.

  2. Measurement of the Cosmic-Ray Antiproton Spectrum at Solar Minimum with a Long-Duration Balloon Flight over Antarctica

    Science.gov (United States)

    Abe, K.; Fuke, H.; Haino, S.; Hams, T.; Hasegawa, M.; Horikoshi, A.; Kim, K. C.; Kusumoto, A.; Lee, M. H.; Makida, Y.; Matsuda, S.; Matsukawa, Y.; Mitchell, J. W.; Nishimura, J.; Nozaki, M.; Orito, R.; Ormes, J. F.; Sakai, K.; Sasaki, M.; Seo, E. S.; Shinoda, R.; Streitmatter, R. E.; Suzuki, J.; Tanaka, K.; Thakur, N.

    2012-01-01

    The energy spectrum of cosmic-ray antiprotons (p-bar's) from 0.17 to 3.5 GeV has been measured using 7886 p-bar's detected by BESS-Polar II during a long-duration flight over Antarctica near solar minimum in December 2007 and January 2008. This shows good consistency with secondary p-bar calculations. Cosmologically primary p-bar's have been investigated by comparing measured and calculated p-bar spectra. BESS-Polar II data.show no evidence of primary p-bar's from the evaporation of primordial black holes.

  3. Measurement of Cosmic-Ray Antiproton Spectrum at Solar Minimum with a Long-Duration Balloon Flight in Antarctica

    Science.gov (United States)

    Abe, K.; Fuke, H.; Haino, S.; Hams, T.; Hasegawa, M.; Horikoshi, A.; Kim, K. C.; Kusumoto, A.; Lee, M. H.; Makida, Y.; Matsuda, S.; Matsukawa, Y.; Mitchell, J. W.; Nishimura, J.; Nozaki, M.; Orito, R.; Ormes, J. F.; Sakai, K.; Sasaki, M.; Seo, E. S.; Shinoda, R.; Streitmatter, R. E.; Suzuki, J.; Tanaka, K.; Thakur, N.

    2011-01-01

    The energy spectrum of cosmic-ray antiprotons (p(raised bar)'s) collected by the BESS-Polar II instrument during a long-duration flight over Antarctica in the solar minimum period of December 2007 through January 2008. The p(raised bar) spectrum measured by BESS-Polar II shows good consistency with secondary p(raised bar) calculations. Cosmologically primary p(raised bar)'s have been searched for by comparing the observed and calculated p(raised bar) spectra. The BESSPolar II result shows no evidence of primary p(raised bar)'s originating from the evaporation of PBH.

  4. The W boson transverse momentum spectrum in proton-antiproton collisions at radical s = 1. 8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Winer, B.L.

    1991-02-01

    The Collider Detector at Fermilab (CDF) was used to measure the transverse momentum distribution of W boson produced in proton-antiproton collisions at the Tevatron collider. The W bosons were identified by the decay W {yields} e{nu}. The results are in good agreement with a next-to-leading order calculation. The cross section for W production with P{sub T} > 50 GeV/c is 423 {plus minus} 58 (stat.) {plus minus} 108 (sys.) pb. 58 refs., 53 figs., 16 tabs.

  5. Proceedings of the Antiproton Science and Technology Workshop Held in Santa Monica, California on 6-9 October 1987

    Science.gov (United States)

    1988-07-01

    from 135 to 300 K", J. Chem. Phys. 65(4), 1539-41 (1976). 433 1975 66. Carsky, Petr; Zahradnik, Rudolf ;-Hobza, Pavel, "Semiempirical Estimates of the...280 (1979). [22’ D. L. Morgan and V. W. Hughes, Phys. Rev. A7, 1811 (1973). [23] H. M. Rosenstock, K. Draxl, B. W. Steiner , and. J. T. Herron, J...ANTIPROTON ANNIHILATION PROCESSES 1960 L.E. Agnew, Jr., T. Elioff, W.B. Fowler, R.L. Lander, W.M.Powell, E. Sergi, H.M. Steiner , H.S. White, C. Wiegand

  6. Peripheral facial nerve palsy after therapeutic endoscopy.

    Science.gov (United States)

    Kim, Eun Jeong; Lee, Jun; Lee, Ji Woon; Lee, Jun Hyung; Park, Chol Jin; Kim, Young Dae; Lee, Hyun Jin

    2015-03-01

    Peripheral facial nerve palsy (FNP) is a mononeuropathy that affects the peripheral part of the facial nerve. Primary causes of peripheral FNP remain largely unknown, but detectable causes include systemic infections (viral and others), trauma, ischemia, tumor, and extrinsic compression. Peripheral FNP in relation to extrinsic compression has rarely been described in case reports. Here, we report a case of a 71-year-old man who was diagnosed with peripheral FNP following endoscopic submucosal dissection. This case is the first report of the development of peripheral FNP in a patient undergoing therapeutic endoscopy. We emphasize the fact that physicians should be attentive to the development of peripheral FNP following therapeutic endoscopy.

  7. Three-dimensional parton distribution functions $g_{1T}$ and $h_{1L}^\\perp$ in the polarized proton-antiproton Drell-Yan process

    CERN Document Server

    Zhu, Jiacai

    2011-01-01

    We present predictions of the unweighted and weighted double spin asymmetries related to the transversal helicity distribution $g_{1T}$ and the longitudinal transversity distribution $h_{1L}^\\perp$, two of eight leading-twist transverse momentum dependent parton distributions (TMDs) or 3-dimensional parton distribution functions (3dPDFs), in the polarized proton-antiproton Drell-Yan process at typical kinematics on the Facility for Antiproton and Ion Research (FAIR). We conclude that FAIR is ideal to access the new 3dPDFs towards a detailed picture of the nucleon structure.

  8. Radiotherapy-induced emesis. An overview

    Energy Technology Data Exchange (ETDEWEB)

    Feyer, P.; Buchali, A.; Hinkelbein, M.; Budach, V. [Department Radiotherapy, Humboldt-University Berlin (Germany); Zimmermann, J.S. [Department Radiotherapy, Christian Albrechts-University Kiel (Germany); Titlbach, O.J. [Department of Medicine I, Hospital Friedrichshain, Berlin (Germany)

    1998-11-01

    Background: A significant number of patients receiving radiotherapy experience the distressing side effects of emesis and nausea. These symptoms are some of the most distressing problems for the patients influencing their quality of life. Methods: International study results concerning radiotherapy-induced emesis are demonstrated. A German multicenter questionnaire examining the strategies to prevent or to treat radiotherapy-induced nausea and emesis is presented. An international analysis concerning incidence of emesis and nausea in fractionated radiotherapy patients is discussed. Finally the consensus of the consensus conference on antiemetic therapy from the Perugia International Cancer Conference V is introduced. Results: Untreated emesis can lead to complications like electrolyte disorders, dehydration, metabolic disturbances and nutrition problems with weight loss. Prophylactic antiemetics are often given to patients receiving single high-dose radiotherapy to the abdomen. A survey has revealed that antiemetic prophylaxis is not routinely offered to the patients receiving fractionated radiotherapy. However, there is a need for an effective treatment of emesis for use in this group of patients, too. In 20% of patients nausea and emesis can cause a treatment interruption because of an inadequate control of symptoms. Like in chemotherapy strategies there exist high, moderate, and low emetogenic treatment regimens in radiotherapy as well. The most emetogenic potential has the total body irradiation followed by radiotherapy to the abdomen. Radiotherapy induced emesis can be treated effectively with conventional antiemetics up to 50%. Conclusions: Studies with total body irradiation, fractionated treatment and high-dose single exposures have cleary demonstrated the value of 5-HT3-receptor antagonist antiemetics. There is a response between 60 and 97%. There is no difference in the efficacy of the different 5-HT3-antagonists. High-risk patients should be prophylactic

  9. Differential imaging diagnosis of a swelling after extraction in a breast cancer patient with radiotherapy and chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Huh, Kyung Hoe; Huh, Min Suk [Seoul National Univ., Seoul (Korea, Republic of); An, Byung Mo; Kim, Mi Ja [Hallym Univ., Chuncheon (Korea, Republic of); Park, Kwan Soo [Inje Univ. Sanggye Paik Hospital, Seoul (Korea, Republic of)

    2006-09-15

    A 60-year-old female, who complained of delayed healing and swelling after extraction of left lower second molar during chemotherapy, visited our department. She had a history of a resection surgery of breast cancer and postoperative radiotherapy. The conventional radiographs showed diffuse primitive bone destruction in posterior mandibular body, which gave the first radiologic impression of osteonecrosis associated with radiotherapy or chemotherapy. And bone metastasis from the breast cancer was also considered in the differential diagnosis. On the enhanced computed tomography (ECT) the posterior mandibular body was occupied by a large expansible lesion showing central low attenuation with peripheral rim enhancement. Magnetic resonance images revealed that the low attenuated area on ECT did not show as high signal intensity as water on T2 weighted image and indicated solid component of a tumor. The final diagnosis was central squamous cell carcinoma. We present the diagnostic imaging features of the patient with special emphasis on the differential diagnosis.

  10. Advancements in radiotherapy for lung cancer in China

    Institute of Scientific and Technical Information of China (English)

    Lujun Zhao; Luhua Wang

    2015-01-01

    Lung cancer is the leading cause of death due to cancer in China. In recent years, great progress has been made in radiotherapy for lung cancer patients in China. The main advance-ments include the fol owing aspects:(1) stereotactic ablative radiotherapy for early stage non-smal cel lung cancer (NSCLC), (2) post-operative radiotherapy for NSCLC, (3) combined chemotherapy and radiotherapy for local y advanced NSCLC, (4) improved radiotherapy for advanced NSCLC, and 5) prediction of radiation-induced lung toxicity.

  11. Grounded theory for radiotherapy practitioners: Informing clinical practice

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, N.A., E-mail: Nadia.Walsh@gstt.nhs.u [Medical Physics Department, Guy' s and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London SE1 7EH (United Kingdom)

    2010-08-15

    Radiotherapy practitioners may be best placed to undertake qualitative research within the context of cancer, due to specialist knowledge of radiation treatment and sensitivity to radiotherapy patient's needs. The grounded theory approach to data collection and analysis is a unique method of identifying a theory directly based on data collected within a clinical context. Research for radiotherapy practitioners is integral to role expansion within the government's directive for evidence-based practice. Due to the paucity of information on qualitative research undertaken by radiotherapy radiographers, this article aims to assess the potential impact of qualitative research on radiotherapy patient and service outcomes.

  12. Radiotherapy in the management of early breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Wei [Westmead Breast Cancer Institute, Westmead Hospital, Westmead, New South Wales (Australia); Department of Radiation Oncology, Westmead Hospital, New South Wales (Australia)

    2013-03-15

    Radiotherapy is an indispensible part of the management of all stages of breast cancer. In this article, the common indications for radiotherapy in the management of early breast cancer (stages 0, I, and II) are reviewed, including whole-breast radiotherapy as part of breast-conserving treatment for early invasive breast cancer and pre-invasive disease of ductal carcinoma in situ, post-mastectomy radiotherapy, locoregional radiotherapy, and partial breast irradiation. Key clinical studies that underpin our current practice are discussed briefly.

  13. Film dosimetry in conformal radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Danciu, C.; Proimos, B.S. [Patras Univ. (Greece). Dept. of Medical Physics

    1995-12-01

    Dosimetry, through a film sandwiched in a transverse cross-section of a solid phantom, is a method of choice in Conformal Radiotherapy because: (a) the blackness (density) of the film at each point offers a measure of the total dose received at that point, and (b) the film is easily calibrated by exposing a film strip in the same cross-section, through a stationary field. The film must therefore have the following properties: (a) it must be slow, in order not to be overexposed, even at a therapeutic dose of 200 cGy, and (b) the response of the film (density versus dose curve) must be independent of the photon energy spectrum. A few slow films were compared. It was found that the Kodak X-Omat V for therapy verification was the best choice. To investigate whether the film response was independent of the photon energy, response curves for six depths, starting from the depth of maximum dose to the depth of 25 cm, in solid phantom were derived. The vertical beam was perpendicular to the anterior surface of the phantom, which was at the distance of 100 cm from the source and the field was 15x15 cm at that distance. This procedure was repeated for photon beams emitted by a Cobalt-60 unit, two 6 MV and 15 MV Linear Accelerators, as well as a 45 MV Betatron. For each of those four different beams the film response was the same for all six depths. The results, as shown in the diagrams, are very satisfactory. The response curve under a geometry similar to that actually applied, when the film is irradiated in a transverse cross-section of the phantom, was derived. The horizontal beam was almost parallel (angle of 85) to the plane of the film. The same was repeated with the central ray parallel to the film (angle 90) and at a distance of 1.5 cm from the horizontal film. The field size was again 15x15 at the lateral entrance surface of the beam. The response curves remained the same, as when the beam was perpendicular to the films.

  14. Treatment results of radical radiotherapy of carcinoma uterine cervix using external beam radiotherapy and high dose rate intracavitary radiotherapy

    Directory of Open Access Journals (Sweden)

    Azad S

    2010-01-01

    Full Text Available Aim: To report the outcome of carcinoma cervix patients treated radically by external beam radiotherapy and high dose rate intracavitary radiotherapy. Material and Methods: From January 2005 to December 2006, a total of 709 newly diagnosed cases of carcinoma cervix were reported in our department. All cases were staged according to the International Federation of Gynecologist and Oncologist staging system. Out of 709 cases, 342 completed radical radiotherapy and were retrospectively analyzed for the presence of local residual disease, local recurrence, distant metastases, radiation reaction, and disease free survival. Results: There were 11(3.22%, 82(23.98%, 232(67.83%, and 17(4.97% patients in stages I, II, III, and IV, respectively. The median follow up time for all patients was 36 months (range 3 -54 months. The overall treatment time (OTT ranged from 52 to 69 days (median 58 days. The 3 year disease free survival rate was 81.8%, 70.7%, 40.08%, and 11.76% for stages I, II, III, and IV, respectively. There were 91 (26.6% cases with local residual diseases, 27(7.9% developed distant metastasis, and 18(5.26% pts had local recurrence. Discussion: The results of this study suggest that radical radiotherapy with HDR brachytherapy was appropriate for the treatment of early staged cancer of uterine cervix. For locally advanced cancer of cervix addition of concurrent chemotherapy, higher radiation doses, reduction of overall treatment time to less than 8 weeks, and use of latest radiotherapy techniques such as IMRT is recommended to improve the results.

  15. Prostate cancer radiotherapy in elderly person; Radiotherapie du cancer de la prostate chez la personne agee

    Energy Technology Data Exchange (ETDEWEB)

    Serre, A. [Centre Alexis-Vautrin, Nancy (France)

    2011-10-15

    The author discusses the issue of prostate cancer radiotherapy in the case of elderly persons. The choice of the therapeutic strategy (local, hormonotherapy, simple monitoring) is complex. Different aspects must be considered: the carcinologic situation assessment, the patient health condition, the patient life expectancy, and the possible side effects of treatment. Radiotherapy appears to be a major therapeutic asset, but dose levels, toxicity effects must then be considered. Short communication

  16. Barriers to palliative radiotherapy referral: A Canadian perspective

    Energy Technology Data Exchange (ETDEWEB)

    Samant, Rajiv S.; Fitzgibbon, Edward; Meng, Joanne; Graham, Ian D. [Univ. of Ottawa. Ottawa, ON (Canada)

    2007-07-15

    Radiotherapy is an effective but underutilized treatment modality for cancer patients. We decided to investigate the factors influencing radiotherapy referral among family physicians in our region. A 30-item survey was developed to determine palliative radiotherapy knowledge and factors influencing referral. It was sent to 400 physicians in eastern Ontario (Canada) and the completed surveys were evaluated. The overall response rate was 50% with almost all physicians seeing cancer patients recently (97%) and the majority (80%) providing palliative care. Approximately 56% had referred patients for radiotherapy previously and 59% were aware of the regional community oncology program. Factors influencing radiotherapy referral included the following: waiting times for radiotherapy consultation and treatment, uncertainty about the benefits of radiotherapy, patient age, and perceived patient inconvenience. Physicians who referred patients for radiotherapy were more than likely to provide palliative care, work outside of urban centres, have hospital privileges and had sought advice from a radiation oncologist in the past. A variety of factors influence the referral of cancer patients for radiotherapy by family physicians and addressing issues such as long waiting times, lack of palliative radiotherapy knowledge and awareness of Cancer Centre services could increase the rate of appropriate radiotherapy patient referral.

  17. Ultrasonographic Evaluation of Peripheral Nerves.

    Science.gov (United States)

    Ali, Zarina S; Pisapia, Jared M; Ma, Tracy S; Zager, Eric L; Heuer, Gregory G; Khoury, Viviane

    2016-01-01

    There are a variety of imaging modalities for evaluation of peripheral nerves. Of these, ultrasonography (US) is often underused. There are several advantages of this imaging modality, including its cost-effectiveness, time-efficient assessment of long segments of peripheral nerves, ability to perform dynamic maneuvers, lack of contraindications, portability, and noninvasiveness. It can provide diagnostic information that cannot be obtained by electrophysiologic or, in some cases, magnetic resonance imaging studies. Ideally, the neurosurgeon can use US as a diagnostic adjunct in the preoperative assessment of a patient with traumatic, neoplastic, infective, or compressive nerve injury. Perhaps its most unique use is in intraoperative surgical planning. In this article, a brief description of normal US nerve anatomy is presented followed by a description of the US appearance of peripheral nerve disease caused by trauma, tumor, infection, and entrapment.

  18. Sorafenib and radiotherapy association for hepatocellular carcinoma; Sorafenib et radiotherapie dans le carcinome hepatocellulaire

    Energy Technology Data Exchange (ETDEWEB)

    Girard, N. [Service de pneumologie, hopital Louis-Pradel, hospices Civils de Lyon, 28, avenue du Doyen-Jean-Lepine, 69500 Bron (France); UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Mornex, F. [UMR 754, universite Claude-Bernard Lyon 1, 43, boulevard du 11-novembre-1918, 69622 Villeurbanne cedex (France); Departement de radiotherapie-oncologie, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France)

    2011-02-15

    Conformal radiotherapy is a promising therapeutic strategy for hepatocellular carcinoma (HCC), producing local control rates above 90% within the radiation beam. However, survival after radiotherapy remains limited by the high frequency of intra- and extra-hepatic recurrences, which occurs in 40-50 and 20-30% of cases, respectively. Sorafenib (BAY43-9006, Nexavar; Bayer, West Haven, CT) is a small molecule inhibitor that demonstrated potent activity to target v-raf murine sarcoma oncogene homologue B1 (BRAF) and VEGFR tyrosine kinases. Sorafenib is the only drug that demonstrated effectiveness to increase overall survival in advanced or metastatic hepatocellular carcinoma. The rationale to combine radiotherapy with sorafenib is the following: (1) targeting RAS-RAF-MAPK and VEGFR signaling pathways, which are specifically activated after exposure to radiation, and responsible for radio-resistance phenomenon; (2) enhancing the oxygen effect through normalization of the surviving tumor vasculature; and (3) synchronization of the cell cycle. Sorafenib and radiotherapy represent complementary strategies, as radiotherapy may be useful to prolong the effect of sorafenib through control of the macroscopic disease, when sorafenib may target latent microscopic disease. Sorafenib and radiotherapy associations are thus based on a relevant biological and clinical rationale and are being evaluated in ongoing phase I-II trials. (authors)

  19. Radiotherapy for inverted papilloma: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Levendag, P.C.; Annyas, A.A.; Escajadillo, J.R.; Elema, J.D. (Rijksuniversiteit Groningen (Netherlands). Academisch Ziekenhuis)

    1984-06-01

    Inverted papilloma is an infrequent tumour of the nasal cavity and paranasal sinuses associated with controversy. The incidence of carcinoma in situ associated with inverted papilloma, has not been very well documented until now. Therefore the authors present a case report characterized by an aggressive clinical behaviour, treated by extensive surgery and ultimately controlled by radiotherapy.

  20. Radiotherapy for inverted papilloma: a case report.

    Science.gov (United States)

    Levendag, P C; Annyas, A A; Escajadillo, J R; Elema, J D

    1984-06-01

    Inverted papilloma is an infrequent tumour of the nasal cavity and paranasal sinuses associated with controversy. The incidence of carcinoma in situ associated with inverted papilloma, has not been very well documented until now. Therefore, we present a case report characterized by an aggressive clinical behaviour, treated by extensive surgery and ultimately controlled by radiotherapy.

  1. Magnetic resonance imaging in radiotherapy treatment planning

    NARCIS (Netherlands)

    Moerland, Marinus Adriaan

    2001-01-01

    From its inception in the early 1970's up to the present, magnetic resonance imaging (MRI) has evolved into a sophisticated technique, which has aroused considerable interest in var- ious subelds of medicine including radiotherapy. MRI is capable of imaging in any plane and does not use ionizing rad

  2. Tumour-host dynamics under radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Placeres Jimenez, Rolando, E-mail: rpjcu@yahoo.com [Departamento de Fi' sica, Universidade Federal de Sao Carlos, Sao Carlos - SP (Brazil); Ortiz Hernandez, Eloy [Centre of Medicine and Complexity, Medical University Carlos J. Finlay, Carretera Central s/n, Camagueey (Cuba)

    2011-09-15

    Highlight: > Tumour-host interaction is modelled by Lotka-Volterra equations. > A brief review of the motion integral and analysis of linear stability is presented. > Radiotherapy is introduced into the model, using a periodic Dirac delta function. > A two-dimensional logistic map is derived from the modified Lotka-Volterra model. > It is shown that tumour can be controlled by a correct selection of therapy strategy. - Abstract: Tumour-host interaction is modelled by the Lotka-Volterra equations. Qualitative analysis and simulations show that this model reproduces all known states of development for tumours. Radiotherapy effect is introduced into the model by means of the linear-quadratic model and the periodic Dirac delta function. The evolution of the system under the action of radiotherapy is simulated and parameter space is obtained, from which certain threshold of effectiveness values for the frequency and applied doses are derived. A two-dimensional logistic map is derived from the modified Lotka-Volterra model and used to simulate the effectiveness of radiotherapy in different regimens of tumour development. The results show the possibility of achieving a successful treatment in each individual case by employing the correct therapeutic strategy.

  3. Towards online MRI-guided radiotherapy

    NARCIS (Netherlands)

    Bol, G.H.

    2015-01-01

    First, we present two offline position verification methods which can be used in radiotherapy for detecting the position of the bony anatomy of a patient automatically with portal imaging, even if every single portal image of each segment of an (IMRT) treatment beam contains insufficient matching in

  4. The Role of Radiotherapy in Acromegaly.

    Science.gov (United States)

    Hannon, Mark J; Barkan, Ariel L; Drake, William M

    2016-01-01

    Radiotherapy has, historically, played a central role in the management of acromegaly, and the last 30 years have seen substantial improvements in the technology used in the delivery of radiation therapy. More recently, the introduction of highly targeted radiotherapy, or 'radiosurgery', has further increased the therapeutic options available in the management of secretory pituitary tumors. Despite these developments, improvements in primary surgical outcomes, an increase in the range and effectiveness of medical therapy options, and long-term safety concerns have combined to dictate that, although still deployed in selected cases, the use of radiotherapy in the management of acromegaly has declined steadily over the past 2 decades. In this article, we review some of the main studies that have documented the efficacy of pituitary radiotherapy on growth hormone hypersecretion and summarize the data around its potential deleterious effects, including hypopituitarism, cranial nerve damage, and the development of radiation-related intracerebral tumors. We also give practical recommendations to guide its future use in patients with acromegaly, generally, as a third-line intervention after neurosurgical intervention in combination with various medical therapy options.

  5. Radical radiotherapy for urinary bladder cancer

    DEFF Research Database (Denmark)

    Fokdal, Lars; von der Maase, Hans; Høyer, Morten

    2006-01-01

    The exact value of radiotherapy in the treatment of muscle-invasive       bladder cancer is difficult to establish, as most studies exploring this       issue are retrospective with different procedures for selecting patients       for treatment, as well as varying treatment strategies. An estima...

  6. Peripheral ameloblastoma: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ju Seop; Kim, Kyoung A; Koh, Kwang Joon [Chonbuk National Univ., Chonju (Korea, Republic of)

    2006-06-15

    Peripheral ameloblastoma is an extremely rate odontogenic soft tissue tumor with histologic characteristics similar to those of the intraosseous ameloblastoma. It appears in the gingiva and oral mucosa. And it usually does not show any bone involvement on radiographs, except for saucer shaped erosion of underlying alveolar bone. Recurrence is considered uncommon. We report a case of peripheral ameloblastoma with bone involvement. Histologically it presented with follicles and nest of tumor cells with palisading pattern. And radiographs showed the typical saucer shaped alveolar bone erosion at the distal area of right mandibular third molar. At 6-mouth follow-up after operation, no local recurrence was noted.

  7. Bias in Peripheral Depression Biomarkers

    DEFF Research Database (Denmark)

    Carvalho, André F; Köhler, Cristiano A; Brunoni, André R

    2016-01-01

    BACKGROUND: To aid in the differentiation of individuals with major depressive disorder (MDD) from healthy controls, numerous peripheral biomarkers have been proposed. To date, no comprehensive evaluation of the existence of bias favoring the publication of significant results or inflating effect...... sizes has been conducted. METHODS: Here, we performed a comprehensive review of meta-analyses of peripheral nongenetic biomarkers that could discriminate individuals with MDD from nondepressed controls. PubMed/MEDLINE, EMBASE, and PsycINFO databases were searched through April 10, 2015. RESULTS: From 15...

  8. Galactic cosmic-ray propagation in the light of AMS-02: Analysis of protons, helium, and antiprotons

    Science.gov (United States)

    Korsmeier, Michael; Cuoco, Alessandro

    2016-12-01

    We present novel constraints on cosmic-ray propagation in the Galaxy using the recent precise measurements of proton and helium spectra from AMS-02, together with preliminary AMS-02 data on the antiproton over proton ratio. To explore efficiently the large (up to 11-dimensional) parameter space we employ the nested-sampling algorithm as implemented in the MultiNest package, interfaced with the Galprop code to compute the model-predicted spectra. We use VOYAGER proton and helium data, sampling the local interstellar spectra, to constrain the solar modulation potential. We find that the turbulence of the Galactic magnetic field is well constrained, i.e., δ =0.3 0-0.02+0.03(stat )-0.04+0.10(sys ) , with uncertainties dominated by systematic effects. Systematic uncertainties are determined checking the robustness of the results to the minimum rigidity cut used to fit the data (from 1 GV to 5 GV), to the propagation scenario (convection vs no convection), and to the uncertainties in the knowledge of the antiproton production cross section. Convection and reacceleration are found to be degenerate and not well constrained singularly when using data above 5 GV. Using data above 1 GV reacceleration is required, vA=25 ±2 km /s , although this value might be significantly affected by the low-energy systematic uncertainty in the solar modulation. In a forthcoming companion paper, we investigate the constraints imposed by AMS-02 measurements on lithium, boron, and carbon.

  9. Effect of the coupling channel on the excitation of hydrogenic atoms by the impact of protons and antiprotons

    Science.gov (United States)

    Tantawi, Reda S.

    2014-02-01

    Excitation of hydrogenic atoms H, He+ and Li++ initially in the 2p excited state to the n = 3 states by impact of protons and antiprotons is studied using the single-center atomic orbital close-coupling formalism in its impact parameter approach. The calculations cover the incident energy range from 1 to 1000 keV, in which the straight-line trajectory description of nuclear motion is applicable and the inertial confinement plasma research is of main interest. The influences of couplings between the n = 2 states, as well as the back coupling to the 2p initial state, on the excitation processes are investigated. Including the back couplings is found to be more important in the case of proton scattering than in the case of antiproton, and neglecting couplings between the n = 2 states is found to increase the effect of the sign of the projectile's charge. The calculated cross sections for the H atom are compared with those obtained by previous theoretical calculations.

  10. Antiprotons from dark matter annihilation through light mediators and a possible excess in AMS-02 $\\pbar/p$ data

    CERN Document Server

    Huang, Xian-Jun; Wu, Yue-Liang; Zhang, Wei-Hong; Zhou, Yu-Feng

    2016-01-01

    We show that in the scenario where dark matter (DM) particles annihilate through light mediators, the energy spectra of the final state cosmic-ray particles depend strongly on the mediator mass. For final state antiprotons, a spectrum with relatively narrow peak occurs when the mediator mass is comparable to the $\\pbar p$ production threshold. Of interest, the latest AMS-02 data on the $\\pbar/p$ flux ratio hint at a bump-like excess over the expected background in the energy range $\\sim100-450$ GeV. We show that such a light mediator scenario is favoured by the latest AMS-02 data over the scenarios of DM direct annihilation into the standard model particles and that of antiprotons produced from inside supernova remnants (SNRs), and is consistent with the upper limits derived from the Fermi-LAT data on the gamma rays towards the dwarf spheroidal galaxies. The $\\pbar/p$ flux ratio with energy above 450 GeV is predicted to fall with energy quickly, which can be easily distinguished from the other two scenarios a...

  11. The Results of Radiotherapy in Locally Advanced

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Hyun Soo; Kang, Seung Hee; Kim, Sang Won; Jun, Mi Seon; Jo, Seon Mi; Lim, Jun Cheol; Oh, Young Taek; Kang, Seock Yoon [Ajou University School of Medicine, Suwon (Korea, Republic of)

    2009-09-15

    We retrospectively studied the outcomes and prognostic factors of patients with locally advanced, unresectable pancreatic cancer who were treated with concurrent chemoradiotherapy (CCRT) or radiotherapy only. Fifty-one patients with locally advanced, unresectable pancreatic cancer (stage IIA{approx}III) who received radiotherapy ({>=}30 Gy) between January 1994 and August 2008 were reviewed retrospectively. The median radiation dose was 39 Gy. Chemotherapy consisted of gemcitabine, cisplatin, or 5-FU alone or in various combinations, and was administered concurrently with radiotherapy in 38 patients. The follow-up period ranged from 2{approx}40 months (median, 8 months). The median survival, and the 1-and 2-year overall survival (OS) rates were 7 months, 15.7%, and 5.9%, respectively. Based on univariate analysis, the baseline CA19-9, performance status, and chemotherapy regimen were significant prognostic factors. The median survival was 8 months for CCRT, and 6 months for radiotherapy alone. The patients treated with gemcitabine-containing regimens had longer survival (median, 10 months) than the patients treated with radiotherapy alone (p=0.027). Twenty-three patients were available to evaluate the patterns of failure. Distant metastases (DM) occurred in 18 patients and regional recurrences were demonstrated in 4 patients. Local progression developed in 14 patients. We analyzed the association between the time-to-DM and the baseline CA19-9 levels for 18 evaluable patients. The median time-to-DM was 20 months for patients with normal baseline CA19-9 levels and 2 months for patients with baseline CA19-9 levels {>=}200 U/ml. CCRT with gemcitabine-based regimens was effective in improving OS in patients with locally advanced, unresectable pancreatic cancer. We suggest that the baseline CA19-9 level is valuable in determining the treatment strategy for patients with locally advanced, unresectable pancreatic cancer.

  12. Evaluation on Geant4 Hadronic Models for Pion Minus, Pion Plus and Neutron Particles as Major Antiproton Annihilation Products

    Science.gov (United States)

    Tavakoli, Mohammad Bagher; Mohammadi, Mohammad Mehdi; Reiazi, Reza; Jabbari, Keyvan

    2015-01-01

    Geant4 is an open source simulation toolkit based on C++, which its advantages progressively lead to applications in research domains especially modeling the biological effects of ionizing radiation at the sub-cellular scale. However, it was shown that Geant4 does not give a reasonable result in the prediction of antiproton dose especially in Bragg peak. One of the reasons could be lack of reliable physic model to predict the final states of annihilation products like pions. Considering the fact that most of the antiproton deposited dose is resulted from high-LET nuclear fragments following pion interaction in surrounding nucleons, we reproduced depth dose curves of most probable energy range of pions and neutron particle using Geant4. We consider this work one of the steps to understand the origin of the error and finally verification of Geant4 for antiproton tracking. Geant4 toolkit version 9.4.6.p01 and Fluka version 2006.3 were used to reproduce the depth dose curves of 220 MeV pions (both negative and positive) and 70 MeV neutrons. The geometry applied in the simulations consist a 20 × 20 × 20 cm3 water tank, similar to that used in CERN for antiproton relative dose measurements. Different physic lists including Quark-Gluon String Precompound (QGSP)_Binary Cascade (BIC)_HP, the recommended setting for hadron therapy, were used. In the case of pions, Geant4 resulted in at least 5% dose discrepancy between different physic lists at depth close to the entrance point. Even up to 15% discrepancy was found in some cases like QBBC compared to QGSP_BIC_HP. A significant difference was observed in dose profiles of different Geant4 physic list at small depths for a beam of pions. In the case of neutrons, large dose discrepancy was observed when LHEP or LHEP_EMV lists were applied. The magnitude of this dose discrepancy could be even 50% greater than the dose calculated by LHEP (or LHEP_EMV) at larger depths. We found that effect different Geant4 physic list in

  13. Evaluation on Geant4 Hadronic Models for Pion Minus, Pion Plus and Neutron Particles as Major Antiproton Annihilation Products.

    Science.gov (United States)

    Tavakoli, Mohammad Bagher; Mohammadi, Mohammad Mehdi; Reiazi, Reza; Jabbari, Keyvan

    2015-01-01

    Geant4 is an open source simulation toolkit based on C++, which its advantages progressively lead to applications in research domains especially modeling the biological effects of ionizing radiation at the sub-cellular scale. However, it was shown that Geant4 does not give a reasonable result in the prediction of antiproton dose especially in Bragg peak. One of the reasons could be lack of reliable physic model to predict the final states of annihilation products like pions. Considering the fact that most of the antiproton deposited dose is resulted from high-LET nuclear fragments following pion interaction in surrounding nucleons, we reproduced depth dose curves of most probable energy range of pions and neutron particle using Geant4. We consider this work one of the steps to understand the origin of the error and finally verification of Geant4 for antiproton tracking. Geant4 toolkit version 9.4.6.p01 and Fluka version 2006.3 were used to reproduce the depth dose curves of 220 MeV pions (both negative and positive) and 70 MeV neutrons. The geometry applied in the simulations consist a 20 × 20 × 20 cm(3) water tank, similar to that used in CERN for antiproton relative dose measurements. Different physic lists including Quark-Gluon String Precompound (QGSP)_Binary Cascade (BIC)_HP, the recommended setting for hadron therapy, were used. In the case of pions, Geant4 resulted in at least 5% dose discrepancy between different physic lists at depth close to the entrance point. Even up to 15% discrepancy was found in some cases like QBBC compared to QGSP_BIC_HP. A significant difference was observed in dose profiles of different Geant4 physic list at small depths for a beam of pions. In the case of neutrons, large dose discrepancy was observed when LHEP or LHEP_EMV lists were applied. The magnitude of this dose discrepancy could be even 50% greater than the dose calculated by LHEP (or LHEP_EMV) at larger depths. We found that effect different Geant4 physic list in

  14. Peripheral neuroblastoma in an adult: Rare disease at a rare site

    Directory of Open Access Journals (Sweden)

    Kadabur Nagendrappa Lokesh

    2015-01-01

    Full Text Available Adult peripheral neuroblastoma represents less than 1% of all malignant primary tumors of peripheral nerves. We report a young adult who presented with swelling over the left wrist with left epitrochlear and axillary lymph nodes. Incision biopsy of the swelling was suggestive of malignant small round cell tumor. On immunohistochemistry, cells were positive for synaptophysin, chromogranin and nonspecific enolase and negative for leucocyte common antigen, cytokeratin, CD99 and myogenin. Urinary vanillyl mandelic acid and homovanillic acid levels were elevated. The patient received 8 cycles of chemotherapy (OJEC. Reassessment positron emission tomography-computed tomography scan showed a complete metabolic response at the primary site and partial response at left axillary lymph nodes. The patient underwent axillary lymph node clearance followed by radiotherapy to the tumor bed and lymph node regions. The patient could not afford autologous haematopoetic stem cell transplant and was started on isotretinoin maintenance. He is on follow-up for 12 months and disease free.

  15. About the creation of proton–antiproton pair at electron–positron collider in the energy range of ψ(3770 mass

    Directory of Open Access Journals (Sweden)

    A.I. Ahmadov

    2014-11-01

    Full Text Available The process of electron–positron annihilation into proton–antiproton pair is considered within the vicinity of ψ(3770 resonance. The interference between the pure electromagnetic intermediate state and the ψ(3770 state is evaluated. It is shown that this interference is destructive and the relative phase between these two contributions is large (ϕ0≈250°.

  16. Search for Wh Production Using High-PT Isolated Like-Sign Dilepton Events in 1.96-TeV Proton-Antiproton Collisions

    Energy Technology Data Exchange (ETDEWEB)

    Wakisaka, Takayuki [Osaka City Univ. (Japan)

    2009-04-01

    The thesis describes search for the neutral Higgs production associated with the W boson using high-PT isolated like-sign (LS) dilepton events in proton-antiproton collisions at a center-of-mass energy of 1.96 TeV.

  17. Peripheral facial weakness (Bell's palsy).

    Science.gov (United States)

    Basić-Kes, Vanja; Dobrota, Vesna Dermanović; Cesarik, Marijan; Matovina, Lucija Zadro; Madzar, Zrinko; Zavoreo, Iris; Demarin, Vida

    2013-06-01

    Peripheral facial weakness is a facial nerve damage that results in muscle weakness on one side of the face. It may be idiopathic (Bell's palsy) or may have a detectable cause. Almost 80% of peripheral facial weakness cases are primary and the rest of them are secondary. The most frequent causes of secondary peripheral facial weakness are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immune disorders, drugs, degenerative diseases of the central nervous system, etc. The diagnosis relies upon the presence of typical signs and symptoms, blood chemistry tests, cerebrospinal fluid investigations, nerve conduction studies and neuroimaging methods (cerebral MRI, x-ray of the skull and mastoid). Treatment of secondary peripheral facial weakness is based on therapy for the underlying disorder, unlike the treatment of Bell's palsy that is controversial due to the lack of large, randomized, controlled, prospective studies. There are some indications that steroids or antiviral agents are beneficial but there are also studies that show no beneficial effect. Additional treatments include eye protection, physiotherapy, acupuncture, botulinum toxin, or surgery. Bell's palsy has a benign prognosis with complete recovery in about 80% of patients, 15% experience some mode of permanent nerve damage and severe consequences remain in 5% of patients.

  18. Peripheral markers of thyroid function

    DEFF Research Database (Denmark)

    Schmidt, Ulla; Nygaard, Birte; Winther Jensen, Ebbe;

    2013-01-01

    the combination therapy. HYPOTHESIS: Peripheral tissue might also be stimulated during T4/T3 combination therapy compared with T4 monotherapy. METHODS: Serum levels of sex hormone-binding globulin (SHBG), pro-collagen-1-N-terminal peptide (PINP), and N-terminal pro-brain natriuretic peptide (NT...

  19. Multiplicity dependence of charged pion, kaon, and (anti)proton production at large transverse momentum in p-Pb collisions at $\\sqrt{s_{\\rm NN}}$= 5.02 TeV

    CERN Document Server

    Adam, Jaroslav; Aggarwal, Madan Mohan; Aglieri Rinella, Gianluca; Agnello, Michelangelo; Agrawal, Neelima; Ahammed, Zubayer; Ahmad, Shakeel; Ahn, Sang Un; Aiola, Salvatore; Akindinov, Alexander; Alam, Sk Noor; Aleksandrov, Dmitry; Alessandro, Bruno; Alexandre, Didier; Alfaro Molina, Jose Ruben; Alici, Andrea; Alkin, Anton; Millan Almaraz, Jesus Roberto; Alme, Johan; Alt, Torsten; Altinpinar, Sedat; Altsybeev, Igor; Alves Garcia Prado, Caio; Andrei, Cristian; Andronic, Anton; Anguelov, Venelin; Anticic, Tome; Antinori, Federico; Antonioli, Pietro; Aphecetche, Laurent Bernard; Appelshaeuser, Harald; Arcelli, Silvia; Arnaldi, Roberta; Arnold, Oliver Werner; Arsene, Ionut Cristian; Arslandok, Mesut; Audurier, Benjamin; Augustinus, Andre; Averbeck, Ralf Peter; Azmi, Mohd Danish; Badala, Angela; Baek, Yong Wook; Bagnasco, Stefano; Bailhache, Raphaelle Marie; Bala, Renu; Balasubramanian, Supraja; Baldisseri, Alberto; Baral, Rama Chandra; Barbano, Anastasia Maria; Barbera, Roberto; Barile, Francesco; Barnafoldi, Gergely Gabor; Barnby, Lee Stuart; Ramillien Barret, Valerie; Bartalini, Paolo; Barth, Klaus; Bartke, Jerzy Gustaw; Bartsch, Esther; Basile, Maurizio; Bastid, Nicole; Basu, Sumit; Bathen, Bastian; Batigne, Guillaume; Batista Camejo, Arianna; Batyunya, Boris; Batzing, Paul Christoph; Bearden, Ian Gardner; Beck, Hans; Bedda, Cristina; Behera, Nirbhay Kumar; Belikov, Iouri; Bellini, Francesca; Bello Martinez, Hector; Bellwied, Rene; Belmont Iii, Ronald John; Belmont Moreno, Ernesto; Belyaev, Vladimir; Benacek, Pavel; Bencedi, Gyula; Beole, Stefania; Berceanu, Ionela; Bercuci, Alexandru; Berdnikov, Yaroslav; Berenyi, Daniel; Bertens, Redmer Alexander; Berzano, Dario; Betev, Latchezar; Bhasin, Anju; Bhat, Inayat Rasool; Bhati, Ashok Kumar; Bhattacharjee, Buddhadeb; Bhom, Jihyun; Bianchi, Livio; Bianchi, Nicola; Bianchin, Chiara; Bielcik, Jaroslav; Bielcikova, Jana; Bilandzic, Ante; Biro, Gabor; Biswas, Rathijit; Biswas, Saikat; Bjelogrlic, Sandro; Blair, Justin Thomas; Blau, Dmitry; Blume, Christoph; Bock, Friederike; Bogdanov, Alexey; Boggild, Hans; Boldizsar, Laszlo; Bombara, Marek; Book, Julian Heinz; Borel, Herve; Borissov, Alexander; Borri, Marcello; Bossu, Francesco; Botta, Elena; Bourjau, Christian; Braun-Munzinger, Peter; Bregant, Marco; Breitner, Timo Gunther; Broker, Theo Alexander; Browning, Tyler Allen; Broz, Michal; Brucken, Erik Jens; Bruna, Elena; Bruno, Giuseppe Eugenio; Budnikov, Dmitry; Buesching, Henner; Bufalino, Stefania; Buncic, Predrag; Busch, Oliver; Buthelezi, Edith Zinhle; Bashir Butt, Jamila; Buxton, Jesse Thomas; Caffarri, Davide; Cai, Xu; Caines, Helen Louise; Calero Diaz, Liliet; Caliva, Alberto; Calvo Villar, Ernesto; Camerini, Paolo; Carena, Francesco; Carena, Wisla; Carnesecchi, Francesca; Castillo Castellanos, Javier Ernesto; Castro, Andrew John; Casula, Ester Anna Rita; Ceballos Sanchez, Cesar; Cerello, Piergiorgio; Cerkala, Jakub; Chang, Beomsu; Chapeland, Sylvain; Chartier, Marielle; Charvet, Jean-Luc Fernand; Chattopadhyay, Subhasis; Chattopadhyay, Sukalyan; Chauvin, Alex; Chelnokov, Volodymyr; Cherney, Michael Gerard; Cheshkov, Cvetan Valeriev; Cheynis, Brigitte; Chibante Barroso, Vasco Miguel; Dobrigkeit Chinellato, David; Cho, Soyeon; Chochula, Peter; Choi, Kyungeon; Chojnacki, Marek; Choudhury, Subikash; Christakoglou, Panagiotis; Christensen, Christian Holm; Christiansen, Peter; Chujo, Tatsuya; Chung, Suh-Urk; Cicalo, Corrado; Cifarelli, Luisa; Cindolo, Federico; Cleymans, Jean Willy Andre; Colamaria, Fabio Filippo; Colella, Domenico; Collu, Alberto; Colocci, Manuel; Conesa Balbastre, Gustavo; Conesa Del Valle, Zaida; Connors, Megan Elizabeth; Contreras Nuno, Jesus Guillermo; Cormier, Thomas Michael; Corrales Morales, Yasser; Cortes Maldonado, Ismael; Cortese, Pietro; Cosentino, Mauro Rogerio; Costa, Filippo; Crochet, Philippe; Cruz Albino, Rigoberto; Cuautle Flores, Eleazar; Cunqueiro Mendez, Leticia; Dahms, Torsten; Dainese, Andrea; Danisch, Meike Charlotte; Danu, Andrea; Das, Debasish; Das, Indranil; Das, Supriya; Dash, Ajay Kumar; Dash, Sadhana; De, Sudipan; De Caro, Annalisa; De Cataldo, Giacinto; De Conti, Camila; De Cuveland, Jan; De Falco, Alessandro; De Gruttola, Daniele; De Marco, Nora; De Pasquale, Salvatore; Deisting, Alexander; Deloff, Andrzej; Denes, Ervin Sandor; Deplano, Caterina; Dhankher, Preeti; Di Bari, Domenico; Di Mauro, Antonio; Di Nezza, Pasquale; Diaz Corchero, Miguel Angel; Dietel, Thomas; Dillenseger, Pascal; Divia, Roberto; Djuvsland, Oeystein; Dobrin, Alexandru Florin; Domenicis Gimenez, Diogenes; Donigus, Benjamin; Dordic, Olja; Drozhzhova, Tatiana; Dubey, Anand Kumar; Dubla, Andrea; Ducroux, Laurent; Dupieux, Pascal; Ehlers Iii, Raymond James; Elia, Domenico; Endress, Eric; Engel, Heiko; Epple, Eliane; Erazmus, Barbara Ewa; Erdemir, Irem; Erhardt, Filip; Espagnon, Bruno; Estienne, Magali Danielle; Esumi, Shinichi; Eum, Jongsik; Evans, David; Evdokimov, Sergey; Eyyubova, Gyulnara; Fabbietti, Laura; Fabris, Daniela; Faivre, Julien; Fantoni, Alessandra; Fasel, Markus; Feldkamp, Linus; Feliciello, Alessandro; Feofilov, Grigorii; Ferencei, Jozef; Fernandez Tellez, Arturo; Gonzalez Ferreiro, Elena; Ferretti, Alessandro; Festanti, Andrea; Feuillard, Victor Jose Gaston; Figiel, Jan; Araujo Silva Figueredo, Marcel; Filchagin, Sergey; Finogeev, Dmitry; Fionda, Fiorella; Fiore, Enrichetta Maria; Fleck, Martin Gabriel; Floris, Michele; Foertsch, Siegfried Valentin; Foka, Panagiota; Fokin, Sergey; Fragiacomo, Enrico; Francescon, Andrea; Frankenfeld, Ulrich Michael; Fronze, Gabriele Gaetano; Fuchs, Ulrich; Furget, Christophe; Furs, Artur; Fusco Girard, Mario; Gaardhoeje, Jens Joergen; Gagliardi, Martino; Gago Medina, Alberto Martin; Gallio, Mauro; Gangadharan, Dhevan Raja; Ganoti, Paraskevi; Gao, Chaosong; Garabatos Cuadrado, Jose; Garcia-Solis, Edmundo Javier; Gargiulo, Corrado; Gasik, Piotr Jan; Gauger, Erin Frances; Germain, Marie; Gheata, Andrei George; Gheata, Mihaela; Ghosh, Premomoy; Ghosh, Sanjay Kumar; Gianotti, Paola; Giubellino, Paolo; Giubilato, Piero; Gladysz-Dziadus, Ewa; Glassel, Peter; Gomez Coral, Diego Mauricio; Gomez Ramirez, Andres; Gonzalez, Victor; Gonzalez Zamora, Pedro; Gorbunov, Sergey; Gorlich, Lidia Maria; Gotovac, Sven; Grabski, Varlen; Grachov, Oleg Anatolievich; Graczykowski, Lukasz Kamil; Graham, Katie Leanne; Grelli, Alessandro; Grigoras, Alina Gabriela; Grigoras, Costin; Grigoryev, Vladislav; Grigoryan, Ara; Grigoryan, Smbat; Grynyov, Borys; Grion, Nevio; Gronefeld, Julius Maximilian; Grosse-Oetringhaus, Jan Fiete; Grossiord, Jean-Yves; Grosso, Raffaele; Guber, Fedor; Guernane, Rachid; Guerzoni, Barbara; Gulbrandsen, Kristjan Herlache; Gunji, Taku; Gupta, Anik; Gupta, Ramni; Haake, Rudiger; Haaland, Oystein Senneset; Hadjidakis, Cynthia Marie; Haiduc, Maria; Hamagaki, Hideki; Hamar, Gergoe; Hamon, Julien Charles; Harris, John William; Harton, Austin Vincent; Hatzifotiadou, Despina; Hayashi, Shinichi; Heckel, Stefan Thomas; Helstrup, Haavard; Herghelegiu, Andrei Ionut; Herrera Corral, Gerardo Antonio; Hess, Benjamin Andreas; Hetland, Kristin Fanebust; Hillemanns, Hartmut; Hippolyte, Boris; Horak, David; Hosokawa, Ritsuya; Hristov, Peter Zahariev; Huang, Meidana; Humanic, Thomas; Hussain, Nur; Hussain, Tahir; Hutter, Dirk; Hwang, Dae Sung; Ilkaev, Radiy; Inaba, Motoi; Incani, Elisa; Ippolitov, Mikhail; Irfan, Muhammad; Ivanov, Marian; Ivanov, Vladimir; Izucheev, Vladimir; Jacazio, Nicolo; Jacobs, Peter Martin; Jadhav, Manoj Bhanudas; Jadlovska, Slavka; Jadlovsky, Jan; Jahnke, Cristiane; Jakubowska, Monika Joanna; Jang, Haeng Jin; Janik, Malgorzata Anna; Pahula Hewage, Sandun; Jena, Chitrasen; Jena, Satyajit; Jimenez Bustamante, Raul Tonatiuh; Jones, Peter Graham; Jusko, Anton; Kalinak, Peter; Kalweit, Alexander Philipp; Kamin, Jason Adrian; Kang, Ju Hwan; Kaplin, Vladimir; Kar, Somnath; Karasu Uysal, Ayben; Karavichev, Oleg; Karavicheva, Tatiana; Karayan, Lilit; Karpechev, Evgeny; Kebschull, Udo Wolfgang; Keidel, Ralf; Keijdener, Darius Laurens; Keil, Markus; Khan, Mohammed Mohisin; Khan, Palash; Khan, Shuaib Ahmad; Khanzadeev, Alexei; Kharlov, Yury; Kileng, Bjarte; Kim, Do Won; Kim, Dong Jo; Kim, Daehyeok; Kim, Hyeonjoong; Kim, Jinsook; Kim, Minwoo; Kim, Se Yong; Kim, Taesoo; Kirsch, Stefan; Kisel, Ivan; Kiselev, Sergey; Kisiel, Adam Ryszard; Kiss, Gabor; Klay, Jennifer Lynn; Klein, Carsten; Klein, Jochen; Klein-Boesing, Christian; Klewin, Sebastian; Kluge, Alexander; Knichel, Michael Linus; Knospe, Anders Garritt; Kobdaj, Chinorat; Kofarago, Monika; Kollegger, Thorsten; Kolozhvari, Anatoly; Kondratev, Valerii; Kondratyeva, Natalia; Kondratyuk, Evgeny; Konevskikh, Artem; Kopcik, Michal; Kostarakis, Panagiotis; Kour, Mandeep; Kouzinopoulos, Charalampos; Kovalenko, Oleksandr; Kovalenko, Vladimir; Kowalski, Marek; Koyithatta Meethaleveedu, Greeshma; Kralik, Ivan; Kravcakova, Adela; Kretz, Matthias; Krivda, Marian; Krizek, Filip; Kryshen, Evgeny; Krzewicki, Mikolaj; Kubera, Andrew Michael; Kucera, Vit; Kuhn, Christian Claude; Kuijer, Paulus Gerardus; Kumar, Ajay; Kumar, Jitendra; Lokesh, Kumar; Kumar, Shyam; Kurashvili, Podist; Kurepin, Alexander; Kurepin, Alexey; Kuryakin, Alexey; Kweon, Min Jung; Kwon, Youngil; La Pointe, Sarah Louise; La Rocca, Paola; Ladron De Guevara, Pedro; Lagana Fernandes, Caio; Lakomov, Igor; Langoy, Rune; Lara Martinez, Camilo Ernesto; Lardeux, Antoine Xavier; Lattuca, Alessandra; Laudi, Elisa; Lea, Ramona; Leardini, Lucia; Lee, Graham Richard; Lee, Seongjoo; Lehas, Fatiha; Lemmon, Roy Crawford; Lenti, Vito; Leogrande, Emilia; Leon Monzon, Ildefonso; Leon Vargas, Hermes; Leoncino, Marco; Levai, Peter; Li, Shuang; Li, Xiaomei; Lien, Jorgen Andre; Lietava, Roman; Lindal, Svein; Lindenstruth, Volker; Lippmann, Christian; Lisa, Michael Annan; Ljunggren, Hans Martin; Lodato, Davide Francesco; Lonne, Per-Ivar; Loginov, Vitaly; Loizides, Constantinos; Lopez, Xavier Bernard; Lopez Torres, Ernesto; Lowe, Andrew John; Luettig, Philipp Johannes; Lunardon, Marcello; Luparello, Grazia; Lutz, Tyler Harrison; Maevskaya, Alla; Mager, Magnus; Mahajan, Sanjay; Mahmood, Sohail Musa; Maire, Antonin; Majka, Richard Daniel; Malaev, Mikhail; Maldonado Cervantes, Ivonne Alicia; Malinina, Liudmila; Mal'Kevich, Dmitry; Malzacher, Peter; Mamonov, Alexander; Manko, Vladislav; Manso, Franck; Manzari, Vito; Marchisone, Massimiliano; Mares, Jiri; Margagliotti, Giacomo Vito; Margotti, Anselmo; Margutti, Jacopo; Marin, Ana Maria; Markert, Christina; Marquard, Marco; Martin, Nicole Alice; Martin Blanco, Javier; Martinengo, Paolo; Martinez Hernandez, Mario Ivan; Martinez-Garcia, Gines; Martinez Pedreira, Miguel; Mas, Alexis Jean-Michel; Masciocchi, Silvia; Masera, Massimo; Masoni, Alberto; Massacrier, Laure Marie; Mastroserio, Annalisa; Matyja, Adam Tomasz; Mayer, Christoph; Mazer, Joel Anthony; Mazzoni, Alessandra Maria; Mcdonald, Daniel; Meddi, Franco; Melikyan, Yuri; Menchaca-Rocha, Arturo Alejandro; Meninno, Elisa; Mercado-Perez, Jorge; Meres, Michal; Miake, Yasuo; Mieskolainen, Matti Mikael; Mikhaylov, Konstantin; Milano, Leonardo; Milosevic, Jovan; Minervini, Lazzaro Manlio; Mischke, Andre; Mishra, Aditya Nath; Miskowiec, Dariusz Czeslaw; Mitra, Jubin; Mitu, Ciprian Mihai; Mohammadi, Naghmeh; Mohanty, Bedangadas; Molnar, Levente; Montano Zetina, Luis Manuel; Montes Prado, Esther; Moreira De Godoy, Denise Aparecida; Perez Moreno, Luis Alberto; Moretto, Sandra; Morreale, Astrid; Morsch, Andreas; Muccifora, Valeria; Mudnic, Eugen; Muhlheim, Daniel Michael; Muhuri, Sanjib; Mukherjee, Maitreyee; Mulligan, James Declan; Gameiro Munhoz, Marcelo; Munzer, Robert Helmut; Murakami, Hikari; Murray, Sean; Musa, Luciano; Musinsky, Jan; Naik, Bharati; Nair, Rahul; Nandi, Basanta Kumar; Nania, Rosario; Nappi, Eugenio; Naru, Muhammad Umair; Ferreira Natal Da Luz, Pedro Hugo; Nattrass, Christine; Rosado Navarro, Sebastian; Nayak, Kishora; Nayak, Ranjit; Nayak, Tapan Kumar; Nazarenko, Sergey; Nedosekin, Alexander; Nellen, Lukas; Ng, Fabian; Nicassio, Maria; Niculescu, Mihai; Niedziela, Jeremi; Nielsen, Borge Svane; Nikolaev, Sergey; Nikulin, Sergey; Nikulin, Vladimir; Noferini, Francesco; Nomokonov, Petr; Nooren, Gerardus; Cabanillas Noris, Juan Carlos; Norman, Jaime; Nyanin, Alexander; Nystrand, Joakim Ingemar; Oeschler, Helmut Oskar; Oh, Saehanseul; Oh, Sun Kun; Ohlson, Alice Elisabeth; Okatan, Ali; Okubo, Tsubasa; Olah, Laszlo; Oleniacz, Janusz; Oliveira Da Silva, Antonio Carlos; Oliver, Michael Henry; Onderwaater, Jacobus; Oppedisano, Chiara; Orava, Risto; Ortiz Velasquez, Antonio; Oskarsson, Anders Nils Erik; Otwinowski, Jacek Tomasz; Oyama, Ken; Ozdemir, Mahmut; Pachmayer, Yvonne Chiara; Pagano, Paola; Paic, Guy; Pal, Susanta Kumar; Pan, Jinjin; Pandey, Ashutosh Kumar; Papikyan, Vardanush; Pappalardo, Giuseppe; Pareek, Pooja; Park, Woojin; Parmar, Sonia; Passfeld, Annika; Paticchio, Vincenzo; Patra, Rajendra Nath; Paul, Biswarup; Pei, Hua; Peitzmann, Thomas; Pereira Da Costa, Hugo Denis Antonio; Peresunko, Dmitry Yurevich; Perez Lara, Carlos Eugenio; Perez Lezama, Edgar; Peskov, Vladimir; Pestov, Yury; Petracek, Vojtech; Petrov, Viacheslav; Petrovici, Mihai; Petta, Catia; Piano, Stefano; Pikna, Miroslav; Pillot, Philippe; Ozelin De Lima Pimentel, Lais; Pinazza, Ombretta; Pinsky, Lawrence; Piyarathna, Danthasinghe; Ploskon, Mateusz Andrzej; Planinic, Mirko; Pluta, Jan Marian; Pochybova, Sona; Podesta Lerma, Pedro Luis Manuel; Poghosyan, Martin; Polishchuk, Boris; Poljak, Nikola; Poonsawat, Wanchaloem; Pop, Amalia; Porteboeuf, Sarah Julie; Porter, R Jefferson; Pospisil, Jan; Prasad, Sidharth Kumar; Preghenella, Roberto; Prino, Francesco; Pruneau, Claude Andre; Pshenichnov, Igor; Puccio, Maximiliano; Puddu, Giovanna; Pujahari, Prabhat Ranjan; Punin, Valery; Putschke, Jorn Henning; Qvigstad, Henrik; Rachevski, Alexandre; Raha, Sibaji; Rajput, Sonia; Rak, Jan; Rakotozafindrabe, Andry Malala; Ramello, Luciano; Rami, Fouad; Raniwala, Rashmi; Raniwala, Sudhir; Rasanen, Sami Sakari; Rascanu, Bogdan Theodor; Rathee, Deepika; Read, Kenneth Francis; Redlich, Krzysztof; Reed, Rosi Jan; Rehman, Attiq Ur; Reichelt, Patrick Simon; Reidt, Felix; Ren, Xiaowen; Renfordt, Rainer Arno Ernst; Reolon, Anna Rita; Reshetin, Andrey; Revol, Jean-Pierre; Reygers, Klaus Johannes; Riabov, Viktor; Ricci, Renato Angelo; Richert, Tuva Ora Herenui; Richter, Matthias Rudolph; Riedler, Petra; Riegler, Werner; Riggi, Francesco; Ristea, Catalin-Lucian; Rocco, Elena; Rodriguez Cahuantzi, Mario; Rodriguez Manso, Alis; Roeed, Ketil; Rogochaya, Elena; Rohr, David Michael; Roehrich, Dieter; Romita, Rosa; Ronchetti, Federico; Ronflette, Lucile; Rosnet, Philippe; Rossi, Andrea; Roukoutakis, Filimon; Roy, Ankhi; Roy, Christelle Sophie; Roy, Pradip Kumar; Rubio Montero, Antonio Juan; Rui, Rinaldo; Russo, Riccardo; Ryabinkin, Evgeny; Ryabov, Yury; Rybicki, Andrzej; Sadovskiy, Sergey; Safarik, Karel; Sahlmuller, Baldo; Sahoo, Pragati; Sahoo, Raghunath; Sahoo, Sarita; Sahu, Pradip Kumar; Saini, Jogender; Sakai, Shingo; Saleh, Mohammad Ahmad; Salzwedel, Jai Samuel Nielsen; Sambyal, Sanjeev Singh; Samsonov, Vladimir; Sandor, Ladislav; Sandoval, Andres; Sano, Masato; Sarkar, Debojit; Sarma, Pranjal; Scapparone, Eugenio; Scarlassara, Fernando; Schiaua, Claudiu Cornel; Schicker, Rainer Martin; Schmidt, Christian Joachim; Schmidt, Hans Rudolf; Schuchmann, Simone; Schukraft, Jurgen; Schulc, Martin; Schuster, Tim Robin; Schutz, Yves Roland; Schwarz, Kilian Eberhard; Schweda, Kai Oliver; Scioli, Gilda; Scomparin, Enrico; Scott, Rebecca Michelle; Sefcik, Michal; Seger, Janet Elizabeth; Sekiguchi, Yuko; Sekihata, Daiki; Selyuzhenkov, Ilya; Senosi, Kgotlaesele; Senyukov, Serhiy; Serradilla Rodriguez, Eulogio; Sevcenco, Adrian; Shabanov, Arseniy; Shabetai, Alexandre; Shadura, Oksana; Shahoyan, Ruben; Shahzad, Muhammed Ikram; Shangaraev, Artem; Sharma, Ankita; Sharma, Mona; Sharma, Monika; Sharma, Natasha; Shigaki, Kenta; Shtejer Diaz, Katherin; Sibiryak, Yury; Siddhanta, Sabyasachi; Sielewicz, Krzysztof Marek; Siemiarczuk, Teodor; Silvermyr, David Olle Rickard; Silvestre, Catherine Micaela; Simatovic, Goran; Simonetti, Giuseppe; Singaraju, Rama Narayana; Singh, Ranbir; Singha, Subhash; Singhal, Vikas; Sinha, Bikash; Sarkar - Sinha, Tinku; Sitar, Branislav; Sitta, Mario; Skaali, Bernhard; Slupecki, Maciej; Smirnov, Nikolai; Snellings, Raimond; Snellman, Tomas Wilhelm; Soegaard, Carsten; Song, Jihye; Song, Myunggeun; Song, Zixuan; Soramel, Francesca; Sorensen, Soren Pontoppidan; Derradi De Souza, Rafael; Sozzi, Federica; Spacek, Michal; Spiriti, Eleuterio; Sputowska, Iwona Anna; Spyropoulou-Stassinaki, Martha; Stachel, Johanna; Stan, Ionel; Stankus, Paul; Stefanek, Grzegorz; Stenlund, Evert Anders; Steyn, Gideon Francois; Stiller, Johannes Hendrik; Stocco, Diego; Strmen, Peter; Alarcon Do Passo Suaide, Alexandre; Sugitate, Toru; Suire, Christophe Pierre; Suleymanov, Mais Kazim Oglu; Suljic, Miljenko; Sultanov, Rishat; Sumbera, Michal; Szabo, Alexander; Szanto De Toledo, Alejandro; Szarka, Imrich; Szczepankiewicz, Adam; Szymanski, Maciej Pawel; Tabassam, Uzma; Takahashi, Jun; Tambave, Ganesh Jagannath; Tanaka, Naoto; Tangaro, Marco-Antonio; Tarhini, Mohamad; Tariq, Mohammad; Tarzila, Madalina-Gabriela; Tauro, Arturo; Tejeda Munoz, Guillermo; Telesca, Adriana; Terasaki, Kohei; Terrevoli, Cristina; Teyssier, Boris; Thaeder, Jochen Mathias; Thomas, Deepa; Tieulent, Raphael Noel; Timmins, Anthony Robert; Toia, Alberica; Trogolo, Stefano; Trombetta, Giuseppe; Trubnikov, Victor; Trzaska, Wladyslaw Henryk; Tsuji, Tomoya; Tumkin, Alexandr; Turrisi, Rosario; Tveter, Trine Spedstad; Ullaland, Kjetil; Uras, Antonio; Usai, Gianluca; Utrobicic, Antonija; Vajzer, Michal; Vala, Martin; Valencia Palomo, Lizardo; Vallero, Sara; Van Der Maarel, Jasper; Van Hoorne, Jacobus Willem; Van Leeuwen, Marco; Vanat, Tomas; Vande Vyvre, Pierre; Varga, Dezso; Diozcora Vargas Trevino, Aurora; Vargyas, Marton; Varma, Raghava; Vasileiou, Maria; Vasiliev, Andrey; Vauthier, Astrid; Vechernin, Vladimir; Veen, Annelies Marianne; Veldhoen, Misha; Velure, Arild; Venaruzzo, Massimo; Vercellin, Ermanno; Vergara Limon, Sergio; Vernet, Renaud; Verweij, Marta; Vickovic, Linda; Viesti, Giuseppe; Viinikainen, Jussi Samuli; Vilakazi, Zabulon; Villalobos Baillie, Orlando; Villatoro Tello, Abraham; Vinogradov, Alexander; Vinogradov, Leonid; Vinogradov, Yury; Virgili, Tiziano; Vislavicius, Vytautas; Viyogi, Yogendra; Vodopyanov, Alexander; Volkl, Martin Andreas; Voloshin, Kirill; Voloshin, Sergey; Volpe, Giacomo; Von Haller, Barthelemy; Vorobyev, Ivan; Vranic, Danilo; Vrlakova, Janka; Vulpescu, Bogdan; Wagner, Boris; Wagner, Jan; Wang, Hongkai; Wang, Mengliang; Watanabe, Daisuke; Watanabe, Yosuke; Weber, Michael; Weber, Steffen Georg; Weiser, Dennis Franz; Wessels, Johannes Peter; Westerhoff, Uwe; Whitehead, Andile Mothegi; Wiechula, Jens; Wikne, Jon; Wilk, Grzegorz Andrzej; Wilkinson, Jeremy John; Williams, Crispin; Windelband, Bernd Stefan; Winn, Michael Andreas; Yang, Hongyan; Yang, Ping; Yano, Satoshi; Yasin, Zafar; Yin, Zhongbao; Yokoyama, Hiroki; Yoo, In-Kwon; Yoon, Jin Hee; Yurchenko, Volodymyr; Yushmanov, Igor; Zaborowska, Anna; Zaccolo, Valentina; Zaman, Ali; Zampolli, Chiara; Correia Zanoli, Henrique Jose; Zaporozhets, Sergey; Zardoshti, Nima; Zarochentsev, Andrey; Zavada, Petr; Zavyalov, Nikolay; Zbroszczyk, Hanna Paulina; Zgura, Sorin Ion; Zhalov, Mikhail; Zhang, Haitao; Zhang, Xiaoming; Zhang, Yonghong; Chunhui, Zhang; Zhang, Zuman; Zhao, Chengxin; Zhigareva, Natalia; Zhou, Daicui; Zhou, You; Zhou, Zhuo; Zhu, Hongsheng; Zhu, Jianhui; Zichichi, Antonino; Zimmermann, Alice; Zimmermann, Markus Bernhard; Zinovjev, Gennady; Zyzak, Maksym

    2016-01-01

    The production of charged pions, kaons and (anti)protons has been measured at mid-rapidity ($-0.5 10$ GeV/$c$), the particle ratios are consistent with those reported for pp and Pb-Pb collisions at the LHC energies. At intermediate $p_{\\rm T}$ the (anti)proton $R_{\\rm pPb}$ shows a Cronin-like enhancement, while pions and kaons show little or no nuclear modification. At high $p_{\\rm T}$ the charged pion, kaon and (anti)proton $R_{\\rm pPb}$ are consistent with unity within statistical and systematic uncertainties.

  20. A peripheral primitive neuroectodermal tumor in the larynx: A case report and literature review.

    Science.gov (United States)

    Ijichi, Kei; Tsuzuki, Toyonori; Adachi, Makoto; Murakami, Shingo

    2016-02-01

    Primitive neuroectodermal tumors (PNETs) are malignant tumors comprised of small round cells of neuroectodermal origin. Current evidence indicates that peripheral PNETs (pPNETs), which arise in the non-central nervous system, possess histological similarity to Ewing's sarcoma. Though the occurrence of pPNETs in the head and neck region is rare, these are aggressive malignant tumors, and long-term survival rates following diagnosis remain poor. The current report presents a case of pPNET and evaluates its significance with regard to previous studies. In the present case, a tumor was located in the larynx of the patient, and was diagnosed as pPNET. Immunohistochemical analysis indicated that tumor cells were positive for cluster of differentiation 99. The patient was treated with surgery, multiagent chemotherapy and radiotherapy. Five years subsequent to treatment, the patient had survived and demonstrated no evidence of disease recurrence. In existing literature concerning pPNET located outside the head and neck region, it is recommended that patients are treated with a combination of resection with a wide surgical margin, multiagent chemotherapy and radiotherapy. The present case report concluded that the combination of surgery, systematic chemotherapy and radiotherapy, offers an improved outcome for pPNET localized to the head and neck region, compared with any of these therapies alone.