WorldWideScience

Sample records for antimicrobial utilization program

  1. Entrez Programming Utilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Entrez Programming Utilities (E-utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at...

  2. Danish Integrated Antimicrobial Resistance Monitoring and Research Program

    Science.gov (United States)

    Heuer, Ole E.; Emborg, Hanne-Dorthe; Bagger-Skjøt, Line; Jensen, Vibeke F.; Rogues, Anne-Marie; Skov, Robert L.; Agersø, Yvonne; Brandt, Christian T.; Seyfarth, Anne Mette; Muller, Arno; Hovgaard, Karin; Ajufo, Justin; Bager, Flemming; Aarestrup, Frank M.; Frimodt-Møller, Niels; Wegener, Henrik C.; Monnet, Dominique L.

    2007-01-01

    Resistance to antimicrobial agents is an emerging problem worldwide. Awareness of the undesirable consequences of its widespread occurrence has led to the initiation of antimicrobial agent resistance monitoring programs in several countries. In 1995, Denmark was the first country to establish a systematic and continuous monitoring program of antimicrobial drug consumption and antimicrobial agent resistance in animals, food, and humans, the Danish Integrated Antimicrobial Resistance Monitoring and Research Program (DANMAP). Monitoring of antimicrobial drug resistance and a range of research activities related to DANMAP have contributed to restrictions or bans of use of several antimicrobial agents in food animals in Denmark and other European Union countries. PMID:18217544

  3. An antimicrobial stewardship program reduces antimicrobial therapy duration and hospital stay in surgical wards.

    Science.gov (United States)

    Güerri-Fernández, R; Villar-García, J; Herrera-Fernández, S; Trenchs-Rodríguez, M; Fernández-Morato, J; Moro, L; Sancho, J; Grande, L; Clará, A; Grau, S; Horcajada, J P

    2016-06-01

    We report a quasi-experimental study of the implementation of an antimicrobial stewardship program in two surgical wards, with a pre-intervention period with just assessment of prescription and an intervention period with a prospective audit on antibiotic prescription model. There was a significant reduction of length of stay and the total days of antimicrobial administration. There were no differences in mortality between groups. The antimicrobial stewardship program led to the early detection of inappropriate empirical antibiotic treatment and was associated with a significant reduction in length of stay and the total duration of antimicrobial therapy. PMID:27167764

  4. Trends in Utility Green Pricing Programs (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Brown, E.

    2006-10-01

    This report presents year-end 2005 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  5. Equity implications of utility energy conservation programs

    Energy Technology Data Exchange (ETDEWEB)

    Sutherland, R.J.

    1994-03-15

    This paper uses the Residential Energy Consumption Survey undertaken by the Energy Information Administration in 1990 to estimate the statistical association between household income and participation in electric utility energy conservation programs and the association between participation and the electricity consumption. The results indicate that utility rebates, energy audits, load management programs and other conservation measures tend to be undertaken at greater frequency by high income households than by low income households. Participants in conservation programs tend to occupy relatively new and energy efficient residences and undertake conservation measures other than utility programs, which suggests that utility sponsored programs are substitutes for other conservation investments. Electricity consumption during 1990 is not significantly less for households participating in utility programs than for nonparticipants, which also implies that utility conservation programs are displacing other conservation investments. Apparently, utility programs are not avoiding costs of new construction and instead are transferring wealth, particularly to high income participating households.

  6. Antimicrobial stewardship program in a Malaysian district hospital: First year experience

    Science.gov (United States)

    Sing, Diana Yap Fui; Boo, Yang Liang; Mukhlis, Roshalina; Chin, Pek Woon; Hoo, Fan Kee

    2016-01-01

    Backgrounds & Objective: Antimicrobial resistance is an alarming public health threat that requires urgent global solution. Implementation of antimicrobial stewardship program (ASP) is an essential practice element for healthcare institutions in gate-keeping judicious antimicrobial use. This study highlighted the development, first year experience, and result of the implementation of ASP utilizing persuasive and restrictive approaches in a Malaysian district hospital. Methods: An observational study was conducted between January 2015 to December 2015 on implementation of ASP among hospitalized inpatients age 12 years old and above. Results: Recommendations were provided for 60% of cases (110 patients) with the average acceptance rate of 83.33%. Majority of the interventions were to stop the antimicrobial therapy (30.3%), and the most common audited antimicrobials was Piperacillin/Tazobactam (25.5%), followed by Meropenem (11.82%), Amoxicillin/Clavulanate and Vancomycin (8.18%) respectively. The concordance rate towards authorization policy was increased in 2015 (71.59% of cases) as compared before the implementation of ASP in 2014 (60.6% of cases). Restrictive enforcement under ASP had been shown to improve significantly adherence rate towards antimicrobials authorization policy (p-value: 0.004). Conclusion: ASP was successfully implemented in a district hospital. Future studies on its clinical outcomes are important to evaluate its effectiveness as well as focus on the improvement to the pre-existing strategies and measures.

  7. Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery

    OpenAIRE

    Bourne, Christina R

    2014-01-01

    The need for new antimicrobials is great in face of a growing pool of resistant pathogenic organisms. This review will address the potential for antimicrobial therapy based on polypharmacological activities within the currently utilized bacterial biosynthetic folate pathway. The folate metabolic pathway leads to synthesis of required precursors for cellular function and contains a critical node, dihydrofolate reductase (DHFR), which is shared between prokaryotes and eukaryotes. The DHFR enz...

  8. Trends in Utility Green Pricing Programs (2006)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Kaiser, M.

    2007-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, more than 750 utilities--or about 25% of all utilities nationally--provide their customers a "green power" option. Through these programs, more than 70 million customers have the ability to purchase renewable energy to meet some portion or all of their electricity needs--or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2006 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  9. The Activity of Antimicrobial Surfaces Varies by Testing Protocol Utilized

    Science.gov (United States)

    Campos, Matias D.; Zucchi, Paola C.; Phung, Ann; Leonard, Steven N.; Hirsch, Elizabeth B.

    2016-01-01

    Background Contaminated hospital surfaces are an important source of nosocomial infections. A major obstacle in marketing antimicrobial surfaces is a lack of efficacy data based on standardized testing protocols. Aim We compared the efficacy of multiple testing protocols against several “antimicrobial” film surfaces. Methods Four clinical isolates were used: one Escherichia coli, one Klebsiella pneumoniae, and two Staphylococcus aureus strains. Two industry methods (modified ISO 22196 and ASTM E2149), a “dried droplet”, and a “transfer” method were tested against two commercially available antimicrobial films, one film in development, an untreated control, and a positive (silver) control film. At 2 (only ISO) and 24 hours following inoculation, bacteria were collected from film surfaces and enumerated. Results Compared to untreated films in all protocols, there were no significant differences in recovery on either commercial brand at 2 or 24 hours after inoculation. The silver surface demonstrated significant microbicidal activity (mean loss 4.9 Log10 CFU/ml) in all methods and time points with the exception of 2 hours in the ISO protocol and the transfer method. Using our novel droplet method, no differences between placebo and active surfaces were detected. The surface in development demonstrated variable activity depending on method, organism, and time point. The ISO demonstrated minimal activity at 2 hours but significant activity at 24 hours (mean 4.5 Log10 CFU/ml difference versus placebo). The ASTEM protocol exhibited significant differences in recovery of staphylococci (mean 5 Log10 CFU/ml) but not Gram-negative isolates (10 fold decrease). Minimal activity was observed with this film in the transfer method. Conclusions Varying results between protocols suggested that efficacy of antimicrobial surfaces cannot be easily and reproducibly compared. Clinical use should be considered and further development of representative methods is needed. PMID

  10. Trends in Utility Green Pricing Programs (2006)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kaiser, Marshall [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2007-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, more than 750 utilities—or about 25% of all utilities nationally—provide their customers a “green power” option. Through these programs, more than 70 million customers have the ability to purchase renewable energy to meet some portion or all of their electricity needs—or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2006 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  11. Trends in Utility Green Pricing Programs (2004)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L.; Brown, E.

    2005-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, nearly 600 utilities in regulated electricity markets--or almost 20% of all utilities nationally--provide their customers a "green power" option. Because some utilities offer programs in conjunction with cooperative associations or other publicly owned power entities, the number of distinct programs totals about 125. Through these programs, more than 40 million customers spanning 34 states have the ability to purchase renewable energy to meet some portion or all of their electricity needs--or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2004 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities as benchmarks by which to gauge the success of their green power programs.

  12. A Multidisciplinary Hospital-based Antimicrobial Use Program: Impact on Hospital Pharmacy Expenditures and Drug Use

    Directory of Open Access Journals (Sweden)

    Suzette Salama

    1996-01-01

    Full Text Available The authors’ hospital embarked on a three-component, multidisciplinary, hospital-based antimicrobial use program to cut costs and reduce inappropriate antimicrobial use. Initially, antimicrobial use patterns and costs were monitored for 12 months. For the next two years, an antimicrobial use program was implemented consisting of three strategies: automatic therapeutic interchanges; antimicrobial restriction policies; and parenteral to oral conversion. The program resulted in a reduction in the antimicrobial portion of the total pharmacy drug budget from 41.6% to 28.2%. Simultaneously, the average cost per dose per patient day dropped from $11.88 in 1991 to $10.16 in 1994. Overall, mean monthly acquisition cost savings rose from $6,810 in 1992 to $27,590 in 1994. This study demonstrates that a multidisciplinary antimicrobial use program in a Canadian hospital can effect dramatic cost savings and serve as a quality assurance activity of physician antimicrobial prescribing behaviour.

  13. Trends in Utility Green Pricing Programs (2005)

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brown, Elizabeth [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2006-10-01

    In the early 1990s, only a handful of utilities offered their customers a choice of purchasing electricity generated from renewable energy sources. Today, more than 600 utilities—or about 20% of all utilities nationally—provide their customers a “green power” option. Because some utilities offer programs in conjunction with cooperative associations or other publicly owned power entities, the number of distinct programs totals more than 130. Through these programs, more than 50 million customers have the ability to purchase renewable energy to meet some portion or all of their electricity needs—or make contributions to support the development of renewable energy resources. Typically, customers pay a premium above standard electricity rates for this service. This report presents year-end 2005 data on utility green pricing programs, and examines trends in consumer response and program implementation over time. The data in this report, which were obtained via a questionnaire distributed to utility green pricing program managers, can be used by utilities to benchmark the success of their green power programs.

  14. Handbook of evaluation of utility DSM programs

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.; Reed, J. [eds.; Bronfman, B.; Fitzpatrick, G.; Hicks, E.; Hirst, E.; Hoffman, M.; Keating, K.; Michaels, H.; Nadel, S.; Peters, J.; Reed, J.; Saxonis, W.; Schoen, A.; Violette, D.

    1991-12-01

    Program evaluation has become a central issue in the world of utility integrated resource planning. The DSM programs that utilities were operating to meet federal requirements or to improve customer relations are now becoming big business. DSM is being considered an important resource in a utility`s portfolio of options. In the last five years, the amount of money that utilities have invested in DSM has grown exponentially in most regulatory jurisdictions. Market analysts are now talking about DSM being a $30 billion industry by the end of the decade. If the large volume of DSM-program investments was not enough to highlight the importance of evaluation, then the introduction of regulatory incentives has really focused the spotlight. This handbook was developed through a process that involved many of those people who represent the diverse constituencies of DSM-program evaluation. We have come to recognize the many technical disciplines that must be employed to evaluate DSM programs. An analysis might start out based on the principles of utility load research to find out what happened, but a combination of engineering and statistical methods must be used to ``triangulate`` an estimate of what would have happened without the program. The difference, of course, is that elusive but prized result of evaluation: what happened as the direct result of the DSM program. Technical performance of DSM measures is not the sole determinant of the answer, either. We also recognize the importance of such behavioral attributes of DSM as persistence and free ridership. Finally, DSM evaluation is meaningless without attention to planning an approach, communicating results to relevant decision-makers, and focusing as much on the process as the impacts of the program. These topics are all covered in this handbook.

  15. Effects of utility DSM programs on risk

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.

    1992-05-01

    Electric utilities face a variety of uncertainties that complicate their long-term resource planning and acquisition. These uncertainties include future economic and load growths, fuel prices, environmental regulations, economic regulations, performance and construction cost of existing power plants, cost and availability of purchased power, and the costs and performance of new demand and supply resources. As utilities increasingly turn to demand-side management (DSM) programs to provide energy and capacity resources, it becomes more important to analyze the interactions between these programs and the uncertainties facing utilities. This report uses a new planning model (DIAMOND, developed at Oak Ridge National Laboratory) to explore quantitatively the uncertainty implications of supply-only vs DSM + supply resource portfolios. The analysis focuses on risks to society, with only limited attention to the allocation of risks among customers, shareholders, and others. Four sets of uncertainties are considered in these analyses: economic growth, fuel prices, the costs to build new power plants, and the costs to operate DSM programs. These four types of uncertainties serve as proxies for the many others that face utilities, including delays in completing power plants (proxied by cost of completing plants) and the energy and load reductions caused by DSM programs (proxied by cost of DSM programs). The two types of resource portfolios are tested against these four sets of uncertainties for the period 1990 to 2010. Sensitivity, scenario, and worst-case analysis methods are used. Results show that it is feasible to analyze the effects on uncertainty of including DSM programs in a utility`s resource mix. In light of these results, utilities, which to date have done very little such analysis, should conduct such studies as part of their integrated-resource planning activities.

  16. Effects of utility DSM programs on risk

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.

    1992-05-01

    Electric utilities face a variety of uncertainties that complicate their long-term resource planning and acquisition. These uncertainties include future economic and load growths, fuel prices, environmental regulations, economic regulations, performance and construction cost of existing power plants, cost and availability of purchased power, and the costs and performance of new demand and supply resources. As utilities increasingly turn to demand-side management (DSM) programs to provide energy and capacity resources, it becomes more important to analyze the interactions between these programs and the uncertainties facing utilities. This report uses a new planning model (DIAMOND, developed at Oak Ridge National Laboratory) to explore quantitatively the uncertainty implications of supply-only vs DSM + supply resource portfolios. The analysis focuses on risks to society, with only limited attention to the allocation of risks among customers, shareholders, and others. Four sets of uncertainties are considered in these analyses: economic growth, fuel prices, the costs to build new power plants, and the costs to operate DSM programs. These four types of uncertainties serve as proxies for the many others that face utilities, including delays in completing power plants (proxied by cost of completing plants) and the energy and load reductions caused by DSM programs (proxied by cost of DSM programs). The two types of resource portfolios are tested against these four sets of uncertainties for the period 1990 to 2010. Sensitivity, scenario, and worst-case analysis methods are used. Results show that it is feasible to analyze the effects on uncertainty of including DSM programs in a utility's resource mix. In light of these results, utilities, which to date have done very little such analysis, should conduct such studies as part of their integrated-resource planning activities.

  17. Transformation of antimicrobial stewardship programs through technology and informatics.

    Science.gov (United States)

    Kullar, Ravina; Goff, Debra A

    2014-06-01

    The successful integration of technology in antimicrobial stewardship programs has made it possible for clinicians to function more efficiently. With government endorsement of electronic health records (EHRs), EHRs and clinical decision support systems (CDSSs) are being used as decision support tools to aid clinicians in efforts to improve antibiotic use. Likewise, medical applications (apps) have provided educational tools easily accessible to clinicians through their mobile devices. In this article, the impact that informatics and technology have had on promoting antibiotic stewardship is described, focusing on EHRs and CDSSs, apps, electronic resources, and social media.

  18. Utility green pricing programs: A statistical analysis of program effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan; Olson, Scott; Bird, Lori; Swezey, Blair

    2004-02-01

    Development of renewable energy. Such programs have grown in number in recent years. The design features and effectiveness of these programs varies considerably, however, leading a variety of stakeholders to suggest specific marketing and program design features that might improve customer response and renewable energy sales. This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs. Statistical analysis is performed on both the residential and non-residential customer segments. Data comes from information gathered through a questionnaire completed for 66 utility green pricing programs in early 2003. The questionnaire specifically gathered data on residential and non-residential participation, amount of renewable energy sold, program length, the type of renewable supply used, program price/cost premiums, types of consumer research and program evaluation performed, different sign-up options available, program marketing efforts, and ancillary benefits offered to participants.

  19. Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery

    Directory of Open Access Journals (Sweden)

    Christina R. Bourne

    2014-01-01

    Full Text Available The need for new antimicrobials is great in face of a growing pool of resistant pathogenic organisms. This review will address the potential for antimicrobial therapy based on polypharmacological activities within the currently utilized bacterial biosynthetic folate pathway. The folate metabolic pathway leads to synthesis of required precursors for cellular function and contains a critical node, dihydrofolate reductase (DHFR, which is shared between prokaryotes and eukaryotes. The DHFR enzyme is currently targeted by methotrexate in anti-cancer therapies, by trimethoprim for antibacterial uses, and by pyrimethamine for anti-protozoal applications. An additional anti-folate target is dihyropteroate synthase (DHPS, which is unique to prokaryotes as they cannot acquire folate through dietary means. It has been demonstrated as a primary target for the longest standing antibiotic class, the sulfonamides, which act synergistically with DHFR inhibitors. Investigations have revealed most DHPS enzymes possess the ability to utilize sulfa drugs metabolically, producing alternate products that presumably inhibit downstream enzymes requiring the produced dihydropteroate. Recent work has established an off-target effect of sulfonamide antibiotics on a eukaryotic enzyme, sepiapterin reductase, causing alterations in neurotransmitter synthesis. Given that inhibitors of both DHFR and DHPS are designed to mimic their cognate substrate, which contain shared substructures, it is reasonable to expect such “off-target” effects. These inhibitors are also likely to interact with the enzymatic neighbors in the folate pathway that bind products of the DHFR or DHPS enzymes and/or substrates of similar substructure. Computational studies designed to assess polypharmacology reiterate these conclusions. This leads to hypotheses exploring the vast utility of multiple members of the folate pathway for modulating cellular metabolism, and includes an appealing capacity for

  20. Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.

    Science.gov (United States)

    Bourne, Christina R

    2014-01-01

    The need for new antimicrobials is great in face of a growing pool of resistant pathogenic organisms. This review will address the potential for antimicrobial therapy based on polypharmacological activities within the currently utilized bacterial biosynthetic folate pathway. The folate metabolic pathway leads to synthesis of required precursors for cellular function and contains a critical node, dihydrofolate reductase (DHFR), which is shared between prokaryotes and eukaryotes. The DHFR enzyme is currently targeted by methotrexate in anti-cancer therapies, by trimethoprim for antibacterial uses, and by pyrimethamine for anti-protozoal applications. An additional anti-folate target is dihyropteroate synthase (DHPS), which is unique to prokaryotes as they cannot acquire folate through dietary means. It has been demonstrated as a primary target for the longest standing antibiotic class, the sulfonamides, which act synergistically with DHFR inhibitors. Investigations have revealed most DHPS enzymes possess the ability to utilize sulfa drugs metabolically, producing alternate products that presumably inhibit downstream enzymes requiring the produced dihydropteroate. Recent work has established an off-target effect of sulfonamide antibiotics on a eukaryotic enzyme, sepiapterin reductase, causing alterations in neurotransmitter synthesis. Given that inhibitors of both DHFR and DHPS are designed to mimic their cognate substrate, which contain shared substructures, it is reasonable to expect such "off-target" effects. These inhibitors are also likely to interact with the enzymatic neighbors in the folate pathway that bind products of the DHFR or DHPS enzymes and/or substrates of similar substructure. Computational studies designed to assess polypharmacology reiterate these conclusions. This leads to hypotheses exploring the vast utility of multiple members of the folate pathway for modulating cellular metabolism, and includes an appealing capacity for prokaryotic

  1. A unique in vivo approach for investigating antimicrobial materials utilizing fistulated animals

    Science.gov (United States)

    Berean, Kyle J.; Adetutu, Eric M.; Zhen Ou, Jian; Nour, Majid; Nguyen, Emily P.; Paull, David; Mcleod, Jess; Ramanathan, Rajesh; Bansal, Vipul; Latham, Kay; Bishop-Hurley, Greg J.; McSweeney, Chris; Ball, Andrew S.; Kalantar-zadeh, Kourosh

    2015-01-01

    Unique in vivo tests were conducted through the use of a fistulated ruminant, providing an ideal environment with a diverse and vibrant microbial community. Utilizing such a procedure can be especially invaluable for investigating the performance of antimicrobial materials related to human and animal related infections. In this pilot study, it is shown that the rumen of a fistulated animal provides an excellent live laboratory for assessing the properties of antimicrobial materials. We investigate microbial colonization onto model nanocomposites based on silver (Ag) nanoparticles at different concentrations into polydimethylsiloxane (PDMS). With implantable devices posing a major risk for hospital-acquired infections, the present study provides a viable solution to understand microbial colonization with the potential to reduce the incidence of infection through the introduction of Ag nanoparticles at the optimum concentrations. In vitro measurements were also conducted to show the validity of the approach. An optimal loading of 0.25 wt% Ag is found to show the greatest antimicrobial activity and observed through the in vivo tests to reduce the microbial diversity colonizing the surface. PMID:26098413

  2. A unique in vivo approach for investigating antimicrobial materials utilizing fistulated animals

    Science.gov (United States)

    Berean, Kyle J.; Adetutu, Eric M.; Zhen Ou, Jian; Nour, Majid; Nguyen, Emily P.; Paull, David; McLeod, Jess; Ramanathan, Rajesh; Bansal, Vipul; Latham, Kay; Bishop-Hurley, Greg J.; McSweeney, Chris; Ball, Andrew S.; Kalantar-Zadeh, Kourosh

    2015-06-01

    Unique in vivo tests were conducted through the use of a fistulated ruminant, providing an ideal environment with a diverse and vibrant microbial community. Utilizing such a procedure can be especially invaluable for investigating the performance of antimicrobial materials related to human and animal related infections. In this pilot study, it is shown that the rumen of a fistulated animal provides an excellent live laboratory for assessing the properties of antimicrobial materials. We investigate microbial colonization onto model nanocomposites based on silver (Ag) nanoparticles at different concentrations into polydimethylsiloxane (PDMS). With implantable devices posing a major risk for hospital-acquired infections, the present study provides a viable solution to understand microbial colonization with the potential to reduce the incidence of infection through the introduction of Ag nanoparticles at the optimum concentrations. In vitro measurements were also conducted to show the validity of the approach. An optimal loading of 0.25 wt% Ag is found to show the greatest antimicrobial activity and observed through the in vivo tests to reduce the microbial diversity colonizing the surface.

  3. Characteristics of Antimicrobial Stewardship Programs at Veterans Affairs Hospitals: Results of a Nationwide Survey.

    Science.gov (United States)

    Chou, Ann F; Graber, Christopher J; Jones, Makoto; Zhang, Yue; Goetz, Matthew Bidwell; Madaras-Kelly, Karl; Samore, Matthew; Kelly, Allison; Glassman, Peter A

    2016-06-01

    BACKGROUND Antimicrobial stewardship programs (ASPs) are variably implemented. OBJECTIVE To characterize variations of antimicrobial stewardship structure and practices across all inpatient Veterans Affairs facilities in 2012 and correlate key characteristics with antimicrobial usage. DESIGN A web-based survey regarding stewardship activities was administered to each facility's designated contact. Bivariate associations between facility characteristics and inpatient antimicrobial use during 2012 were determined. SETTING Total of 130 Veterans Affairs facilities with inpatient services. RESULTS Of 130 responding facilities, 29 (22%) had a formal policy establishing an ASP, and 12 (9%) had an approved ASP business plan. Antimicrobial stewardship teams were present in 49 facilities (38%); 34 teams included a clinical pharmacist with formal infectious diseases (ID) training. Stewardship activities varied across facilities, including development of yearly antibiograms (122 [94%]), formulary restrictions (120 [92%]), stop orders for antimicrobial duration (98 [75%]), and written clinical pathways for specific conditions (96 [74%]). Decreased antimicrobial usage was associated with having at least 1 full-time ID physician (P=.03), an ID fellowship program (P=.003), and a clinical pharmacist with formal ID training (P=.006) as well as frequency of systematic patient-level reviews of antimicrobial use (P=.01) and having a policy to address antimicrobial use in the context of Clostridium difficile infection (P=.01). Stop orders for antimicrobial duration were associated with increased use (P=.03). CONCLUSIONS ASP-related activities varied considerably. Decreased antibiotic use appeared related to ID presence and certain select practices. Further statistical assessments may help optimize antimicrobial practices. Infect Control Hosp Epidemiol 2016;37:647-654. PMID:26905338

  4. Antimicrobial resistance programs in canada 1995-2010: a critical evaluation

    Directory of Open Access Journals (Sweden)

    Conly John M

    2012-02-01

    Full Text Available Abstract Background In Canada, systematic efforts for controlling antibiotic resistance began in 1997 following a national Consensus Conference. The Canadian strategy produced 27 recommendations, one of which was the formation of the Canadian Committee on Antibiotic Resistance (CCAR. In addition several other organizations began working on a national or provincial basis over the ensuing years on one or more of the 3 identified core areas of the strategy. Critical evaluation of the major programs within Canada which focused on antimicrobial resistance and the identified core components has not been previously conducted. Findings Data was collected from multiple sources to determine the components of four major AMR programs that were considered national based on their scope or in the delivery of their mandates. Assessment of program components was adapted from the report from the International Forum on Antibiotic Resistance colloquium. Most of the programs used similar tools but only the Do Bugs Need Drugs Program (DBND had components directed towards day cares and schools. Surveillance programs for antimicrobial resistant pathogens have limitations and/or significant sources of bias. Overall, there has been a 25.3% decrease in oral antimicrobial prescriptions in Canada since 1995, mainly due to decreases in β lactams, sulphonamides and tetracyclines in temporal association with multiple programs with the most comprehensive and sustained national programs being CCAR and DBND. Conclusions Although there has been a substantial decrease in oral antimicrobial prescriptions in Canada since 1995, there remains a lack of leadership and co-ordination of antimicrobial resistance activities.

  5. A Review of Quality Measures for Assessing the Impact of Antimicrobial Stewardship Programs in Hospitals.

    Science.gov (United States)

    Akpan, Mary Richard; Ahmad, Raheelah; Shebl, Nada Atef; Ashiru-Oredope, Diane

    2016-01-01

    The growing problem of antimicrobial resistance (AMR) has led to calls for antimicrobial stewardship programs (ASP) to control antibiotic use in healthcare settings. Key strategies include prospective audit with feedback and intervention, and formulary restriction and preauthorization. Education, guidelines, clinical pathways, de-escalation, and intravenous to oral conversion are also part of some programs. Impact and quality of ASP can be assessed using process or outcome measures. Outcome measures are categorized as microbiological, patient or financial outcomes. The objective of this review was to provide an overview of quality measures for assessing ASP and the reported impact of ASP in peer-reviewed studies, focusing particularly on patient outcomes. A literature search of papers published in English between 1990 and June 2015 was conducted in five databases using a combination of search terms. Primary studies of any design were included. A total of 63 studies were included in this review. Four studies defined quality metrics for evaluating ASP. Twenty-one studies assessed the impact of ASP on antimicrobial utilization and cost, 25 studies evaluated impact on resistance patterns and/or rate of Clostridium difficile infection (CDI). Thirteen studies assessed impact on patient outcomes including mortality, length of stay (LOS) and readmission rates. Six of these 13 studies reported non-significant difference in mortality between pre- and post-ASP intervention, and five reported reductions in mortality rate. On LOS, six studies reported shorter LOS post intervention; a significant reduction was reported in one of these studies. Of note, this latter study reported significantly (p < 0.001) higher unplanned readmissions related to infections post-ASP. Patient outcomes need to be a key component of ASP evaluation. The choice of metrics is influenced by data and resource availability. Controlling for confounders must be considered in the design of evaluation studies

  6. A Review of Quality Measures for Assessing the Impact of Antimicrobial Stewardship Programs in Hospitals

    Directory of Open Access Journals (Sweden)

    Mary Richard Akpan

    2016-01-01

    Full Text Available The growing problem of antimicrobial resistance (AMR has led to calls for antimicrobial stewardship programs (ASP to control antibiotic use in healthcare settings. Key strategies include prospective audit with feedback and intervention, and formulary restriction and preauthorization. Education, guidelines, clinical pathways, de-escalation, and intravenous to oral conversion are also part of some programs. Impact and quality of ASP can be assessed using process or outcome measures. Outcome measures are categorized as microbiological, patient or financial outcomes. The objective of this review was to provide an overview of quality measures for assessing ASP and the reported impact of ASP in peer-reviewed studies, focusing particularly on patient outcomes. A literature search of papers published in English between 1990 and June 2015 was conducted in five databases using a combination of search terms. Primary studies of any design were included. A total of 63 studies were included in this review. Four studies defined quality metrics for evaluating ASP. Twenty-one studies assessed the impact of ASP on antimicrobial utilization and cost, 25 studies evaluated impact on resistance patterns and/or rate of Clostridium difficile infection (CDI. Thirteen studies assessed impact on patient outcomes including mortality, length of stay (LOS and readmission rates. Six of these 13 studies reported non-significant difference in mortality between pre- and post-ASP intervention, and five reported reductions in mortality rate. On LOS, six studies reported shorter LOS post intervention; a significant reduction was reported in one of these studies. Of note, this latter study reported significantly (p < 0.001 higher unplanned readmissions related to infections post-ASP. Patient outcomes need to be a key component of ASP evaluation. The choice of metrics is influenced by data and resource availability. Controlling for confounders must be considered in the design of

  7. A cost-effectiveness analysis of two different antimicrobial stewardship programs.

    Science.gov (United States)

    Okumura, Lucas Miyake; Riveros, Bruno Salgado; Gomes-da-Silva, Monica Maria; Veroneze, Izelandia

    2016-01-01

    There is a lack of formal economic analysis to assess the efficiency of antimicrobial stewardship programs. Herein, we conducted a cost-effectiveness study to assess two different strategies of Antimicrobial Stewardship Programs. A 30-day Markov model was developed to analyze how cost-effective was a Bundled Antimicrobial Stewardship implemented in a university hospital in Brazil. Clinical data derived from a historical cohort that compared two different strategies of antimicrobial stewardship programs and had 30-day mortality as main outcome. Selected costs included: workload, cost of defined daily doses, length of stay, laboratory and imaging resources used to diagnose infections. Data were analyzed by deterministic and probabilistic sensitivity analysis to assess model's robustness, tornado diagram and Cost-Effectiveness Acceptability Curve. Bundled Strategy was more expensive (Cost difference US$ 2119.70), however, it was more efficient (US$ 27,549.15 vs 29,011.46). Deterministic and probabilistic sensitivity analysis suggested that critical variables did not alter final Incremental Cost-Effectiveness Ratio. Bundled Strategy had higher probabilities of being cost-effective, which was endorsed by cost-effectiveness acceptability curve. As health systems claim for efficient technologies, this study conclude that Bundled Antimicrobial Stewardship Program was more cost-effective, which means that stewardship strategies with such characteristics would be of special interest in a societal and clinical perspective.

  8. Implementation of an antimicrobial stewardship program on the medical-surgical service of a 100-bed community hospital

    OpenAIRE

    Storey Donald F; Pate Perry G; Nguyen Autumn TT; Chang Fung

    2012-01-01

    Abstract Background Antimicrobial stewardship has been promoted as a key strategy for coping with the problems of antimicrobial resistance and Clostridium difficile. Despite the current call for stewardship in community hospitals, including smaller community hospitals, practical examples of stewardship programs are scarce in the reported literature. The purpose of the current report is to describe the implementation of an antimicrobial stewardship program on the medical-surgical service of a ...

  9. Utility battery storage systems program report for FY 94

    Energy Technology Data Exchange (ETDEWEB)

    Butler, P.C.

    1995-03-01

    Sandia National Laboratories, New Mexico, conducts the Utility Battery Storage Systems Program, which is sponsored by the US Department of Energy`s Office of Energy Management. The goal of this program is to assist industry in developing cost-effective battery systems as a utility resource option by 2000. Sandia is responsible for the engineering analyses, contracted development, and testing of rechargeable batteries and systems for utility energy storage applications. This report details the technical achievements realized during fiscal year 1994.

  10. Review of evaluations of utility home-energy-audit programs

    Science.gov (United States)

    Berry, L.; Soderstrom, J.; Hirst, E.; Newman, B.; Weaver, R.

    1981-03-01

    Evaluation efforts of utilities with active home energy audit programs are reviewed to suggest methodologies, issues, and data that can contribute to the development of a comprehensive Residential Conservation Service evaluation plan. On the basis mainly of written reports received from the utilities, findings about customer response to programs are summarized. The topics discussed include: correlates of program penetration rates; use of financing; attitudes toward programs; actions taken; characteristics of participants; and energy savings due to programs. Particular attention is given to three studies (Tennessee Valley Authority, Seattle City Light, and Pacific Gas and Electric) that analyze fuel consumption records as part of the evaluation.

  11. Nuclear Education and Training Programs of Potential Interest to Utilities.

    Science.gov (United States)

    Atomic Energy Commission, Washington, DC.

    This compilation of education and training programs related to nuclear applications in electric power generation covers programs conducted by nuclear reactor vendors, public utilities, universities, technical institutes, and community colleges, which were available in December 1968. Several training-program consultant services are also included.…

  12. Utility battery storage systems. Program report for FY95

    Energy Technology Data Exchange (ETDEWEB)

    Butler, P.C.

    1996-03-01

    Sandia National Laboratories, New Mexico, conducts the Utility Battery Storage Systems Program, which is sponsored by the U.S. Department of Energy`s Office of Utility Technologies. The goal of this program is to assist industry in developing cost-effective battery systems as a utility resource option by 2000. Sandia is responsible for the engineering analyses, contracted development, and testing of rechargeable batteries and systems for utility energy storage applications. This report details the technical achievements realized during fiscal year 1995.

  13. Musical Ability Utilization Program. Final Report.

    Science.gov (United States)

    Olanoff, Martin; Kirschner, Louise

    This research undertook to determine the nature and extent of academic and motivational change in low-achieving junior high school students with some talent in music who participated in a special music training program. About 100 students in each of five schools were selected by a screening instrument and assigned randomly to experimental or…

  14. Utility investments in low-income-energy-efficiency programs

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.A. [Oak Ridge National Lab., TN (United States); Beyer, M.A. [Aspen Systems Corp., Oak Ridge, TN (United States); Eisenberg, J.; Power, M. [Economic Opportunity Research Institute, Washington, DC (United States); Lapsa, E.J. [Manhattan Data Systems, Knoxville, TN (United States)

    1994-09-01

    The objective of this study is to describe the energy-efficiency programs being operated by utilities for low-income customers. The study focuses, in particular, on programs that install major residential weatherization measures free-of-charge to low-income households. A survey was mailed to a targeted list of 600 utility program managers. Follow-up telephone calls were made to key non- respondents, and a random sample of other non-respondents also was contacted. Completed surveys were received from 180 utilities, 95 of which provided information on one or more of their 1992 low-income energy-efficiency programs for a total of 132 individual programs. These 132 utility programs spent a total of $140.6 million in 1992. This represents 27% of the total program resources available to weatherize the dwellings of low-income households in that year. Both the total funding and the number of programs has grown by 29% since 1989. A majority of the 132 programs are concentrated in a few regions of the country (California, the Pacific Northwest, the Upper Midwest, and the Northeast). Although a majority of the programs are funded by electric utilities, gas utilities have a significantly greater average expenditure per participant ($864 vs. $307 per participant). The most common primary goal of low-income energy-efficiency programs operating in 1992 was {open_quotes}to make energy services more affordable to low-income customers{close_quotes}. Only 44% of the programs were operated primarily to provide a cost-effective energy resource. Based on a review of household and measure selection criteria, equity and not the efficiency of resource acquisition appears to dominate the design of these programs.

  15. Electric-utility DSM programs in a competitive market

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.

    1994-04-01

    During the past few years, the costs and effects of utility demand-side management (DSM) programs have grown sharply. In 1989, US electric utilities spent 0.5% of revenues on such programs and cut total electricity consumption by 0.6%. By 1992, these numbers had increased to 1.3% and 1.2%, respectively. Utility projections, as of early 1993, of DSM expenditures and energy savings for 1997 were 1.7% and 2.5%, respectively. Whether this projected growth comes to pass may depend on current debates about deregulation of, and increased competition in, the electric-utility industry. This report examines the factors likely to affect utility DSM programs in a more competitive environment. The electric-utility industry faces two forces that may conflict with each other. One is the pressure to open up both wholesale and retail markets for competition. The net effect of such competition, especially at the retail level, would have much greater emphasis on electricity prices and less emphasis on energy services. Such an outcome would force a sharp reduction in the scale of DSM programs that are funded by customers in general. The second force is increased concern about environmental quality and global warming. Because utilities are major contributors to US carbon dioxide emissions, the Administration`s Climate Change Action Plan calls on utilities to reduce such emissions. DSM programs are one key way to do that and, in the process, to cut customer electric bills and improve economic productivity. This report discusses the forms of competition and how they might affect DSM programs. It examines the important roles that state regulatory commissions could play to affect retail competition and utility DSM programs. The report also considers the effects of DSM programs on retail electricity prices.

  16. Antimicrobial agents' utilization and cost pattern in an Intensive Care Unit of a Teaching Hospital in South India

    Directory of Open Access Journals (Sweden)

    Nikhilesh Anand

    2016-01-01

    Full Text Available Background and Aims: High utilization and inappropriate usage of antimicrobial agents (AMAs in an Intensive Care Unit (ICU increases resistant organisms, morbidity, mortality, and treatment cost. Prescription audit and active feedback are a proven method to check the irrational prescription. Measuring drug utilization in DDD/100 bed-days is proposed by the WHO to analyze and compare the utilization of drugs. Data of AMAs utilization are required for planning an antibiotic policy and for follow-up of intervention strategies. Hence, in this study, we proposed to evaluate the utilization pattern and cost analysis of AMA used in the ICU. Methodology: A prospective observational study was conducted for 1 year from January 1, 2014, to December 31, 2014, and the data were obtained from the ICU of a tertiary care hospital. The demographic data, disease data, relevant investigation, the utilization of different classes of AMAs (WHO-ATC classification as well as individual drugs and their costs were recorded. Results: One thousand eight hundred and sixty-two prescriptions of AMAs were recorded during the study period with an average of 1.73 ± 0.04 prescriptions/patient. About 80.4% patients were prescribed AMAs during admission. Ceftriaxone (22.77% was the most commonly prescribed AMA followed by piperacillin/tazobactam (15.79%, metronidazole (12%, amoxicillin/clavulanic acid (6.44%, and azithromycin (4.34%. Ceftriaxone, piperacillin/tazobactam, metronidazole, and linezolid were the five maximally utilized AMAs with 38.52, 19.22, 14.34, 8.76, and 8.16 DDD/100 bed-days respectively. An average cost of AMAs used per patient was 2213 Indian rupees (INR. Conclusion: A high utilization of AMAs and a high cost of treatment were noticed which was comparable to other published data, though an increased use of newer AMAs such as linezolid, clindamycin, meropenem, colistin was noticed.

  17. NASA's Space Launch System (SLS) Program: Mars Program Utilization

    Science.gov (United States)

    May, Todd A.; Creech, Stephen D.

    2012-01-01

    NASA's Space Launch System is being designed for safe, affordable, and sustainable human and scientific exploration missions beyond Earth's orbit (BEO), as directed by the NASA Authorization Act of 2010 and NASA's 2011 Strategic Plan. This paper describes how the SLS can dramatically change the Mars program's science and human exploration capabilities and objectives. Specifically, through its high-velocity change (delta V) and payload capabilities, SLS enables Mars science missions of unprecedented size and scope. By providing direct trajectories to Mars, SLS eliminates the need for complicated gravity-assist missions around other bodies in the solar system, reducing mission time, complexity, and cost. SLS's large payload capacity also allows for larger, more capable spacecraft or landers with more instruments, which can eliminate the need for complex packaging or "folding" mechanisms. By offering this capability, SLS can enable more science to be done more quickly than would be possible through other delivery mechanisms using longer mission times.

  18. SSL Pricing and Efficacy Trend Analysis for Utility Program Planning

    Energy Technology Data Exchange (ETDEWEB)

    Tuenge, J. R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-10-01

    Report to help utilities and energy efficiency organizations forecast the order in which important SSL applications will become cost-effective and estimate when each "tipping point" will be reached. Includes performance trend analysis from DOE's LED Lighting Facts® and CALiPER programs plus cost analysis from various sources.

  19. Implementation of an antimicrobial stewardship program on the medical-surgical service of a 100-bed community hospital

    Directory of Open Access Journals (Sweden)

    Storey Donald F

    2012-10-01

    Full Text Available Abstract Background Antimicrobial stewardship has been promoted as a key strategy for coping with the problems of antimicrobial resistance and Clostridium difficile. Despite the current call for stewardship in community hospitals, including smaller community hospitals, practical examples of stewardship programs are scarce in the reported literature. The purpose of the current report is to describe the implementation of an antimicrobial stewardship program on the medical-surgical service of a 100-bed community hospital employing a core strategy of post-prescriptive audit with intervention and feedback. Methods For one hour twice weekly, an infectious diseases physician and a clinical pharmacist audited medical records of inpatients receiving systemic antimicrobial therapy and made non-binding, written recommendations that were subsequently scored for implementation. Defined daily doses (DDDs; World Health Organization Center for Drug Statistics Methodology and acquisition costs per admission and per patient-day were calculated monthly for all administered antimicrobial agents. Results The antimicrobial stewardship team (AST made one or more recommendations for 313 of 367 audits during a 16-month intervention period (September 2009 – December 2010. Physicians implemented recommendation(s from each of 234 (75% audits, including from 85 of 115 for which discontinuation of all antimicrobial therapy was recommended. In comparison to an 8-month baseline period (January 2009 – August 2009, there was a 22% decrease in defined daily doses per 100 admissions (P = .006 and a 16% reduction per 1000 patient-days (P = .013. There was a 32% reduction in antimicrobial acquisition cost per admission (P = .013 and a 25% acquisition cost reduction per patient-day (P = .022. Conclusions An effective antimicrobial stewardship program was implemented with limited resources on the medical-surgical service of a 100-bed community hospital.

  20. Current activities handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-02-27

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the activities each of the thirteen state legislatures potentially affected by the Formerly Utilized Sites Remedial Action Program. It contains a description of the state legislative procedural rules and a schedule of each legislative session; a summary of pending relevant legislation; the name and telephone number of legislative and state agency contacts; and the full text of all bills identified.

  1. Current activities handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the activities each of the thirteen state legislatures potentially affected by the Formerly Utilized Sites Remedial Action Program. It contains a description of the state legislative procedural rules and a schedule of each legislative session; a summary of pending relevant legislation; the name and telephone number of legislative and state agency contacts; and the full text of all bills identified

  2. The Daniel K. Inouye College of Pharmacy Scripts: The Development of Antimicrobial Stewardship Programs in Hawai'i.

    Science.gov (United States)

    Goo, Roy Alan Sh; Chu, Cherie Hl; Yoneda, Melissa K; Ma, Carolyn Sj

    2016-07-01

    In recent years the misuse of antimicrobials has contributed to the growing problem of antimicrobial resistance. Antimicrobial Stewardship Programs (ASP) decrease the misuse of antimicrobials by supporting a rational, systematic approach. ASP strategies vary from broad-ranging policies and other decision support tools to prospective audit review of patients on antimicrobials. Many healthcare facilities, however, have been slow to adopt stewardship attributable to the fact that early ASP models required individuals with specialized training, and a significant amount of time and infrastructural investment from facilities. In response to the increasing need for ASPs in Hawai'i, the Hawai'i Department of Health (HDOH) partnered with the Daniel K. Inouye College of Pharmacy (DKICP) to develop the Hawai'i Antimicrobial Stewardship Collaborative (HASC), a voluntary collaboration whose main objective is to assist hospital institutions in the implementation of a simplified model of the Centers for Disease Control and Prevention's Core Elements of Hospital Antimicrobial Stewardship Programs. The work of HASC places Hawai'i's health care institutions in an advantageous position to be able to comply with impending accreditation standards relating to antibiotics and infections. PMID:27437167

  3. Utility of Greater Wax Moth Larva (Galleria mellonella) for Evaluating the Toxicity and Efficacy of New Antimicrobial Agents.

    Science.gov (United States)

    Desbois, Andrew P; Coote, Peter J

    2012-01-01

    There is an urgent need for new antimicrobial agents to combat infections caused by drug-resistant pathogens. Once a compound is shown to be effective in vitro, it is necessary to evaluate its efficacy in an animal infection model. Typically, this is achieved using a mammalian model, but such experiments are costly, time consuming, and require full ethical consideration. Hence, cheaper and ethically more acceptable invertebrate models of infection have been introduced, including the larvae of the greater wax moth Galleria mellonella. Invertebrates have an immune system that is functionally similar to the innate immune system of mammals, and often identical virulence and pathogenicity factors are used by human pathogenic microbes to infect wax moth larvae and mammals. Moreover, the virulence of many human pathogens is comparable in wax moth larvae and mammals. Using key examples from the literature, this chapter highlights the benefits of using the wax moth larva model to provide a rapid, inexpensive, and reliable evaluation of the toxicity and efficacy of new antimicrobial agents in vivo and prior to the use of more expensive mammalian models. This simple insect model can bridge the gap between in vitro studies and mammalian experimentation by screening out compounds with a low likelihood of success, while providing greater justification for further studies in mammalian systems. Thus, broader implementation of the wax moth larva model into anti-infective drug discovery and development programs could reduce the use of mammals during preclinical assessments and the overall cost of drug development. PMID:22305092

  4. Cost-Utility Analysis of a Cardiac Telerehabilitation Program

    DEFF Research Database (Denmark)

    Kidholm, Kristian; Rasmussen, Maja Kjær; Andreasen, Jan Jesper;

    2016-01-01

    BACKGROUND: Cardiac rehabilitation can reduce mortality of patients with cardiovascular disease, but a frequently low participation rate in rehabilitation programs has been found globally. The objective of the Teledialog study was to assess the cost-utility (CU) of a cardiac telerehabilitation (CTR......) program. The aim of the intervention was to increase the patients' participation in the CTR program. At discharge, an individualized 3-month rehabilitation plan was formulated for each patient. At home, the patients measured their own blood pressure, pulse, weight, and steps taken for 3 months. MATERIALS...... was higher in the intervention group, but the difference was not statistically significant. The incremental CU ratio was more than €400,000 per QALY gained. CONCLUSIONS: Even though the rehabilitation activities increased, the program does not appear to be cost-effective. The intervention itself...

  5. Approaches to Modifying the Behavior of Clinicians Who Are Noncompliant With Antimicrobial Stewardship Program Guidelines.

    Science.gov (United States)

    Goldstein, Ellie J C; Goff, Debra A; Reeve, William; Naumovski, Snezana; Epson, Erin; Zenilman, Jonathan; Kaye, Keith S; File, Thomas M

    2016-08-15

    Antimicrobial stewardship programs (ASPs) are a key national initiative to promote appropriate use of antibiotics and to reduce the burden of resistance. The dilemma of managing the outlier physician is especially complex. We outline strategies to establish a successful ASP that reviews appropriate efforts to achieve the goal of modifying outlier physicians' behavior. One must try to differentiate deviation from ASP norms from all other issues of outliers. Essential elements include identifying and understanding the local problems, planning, and achieving hospital administration and medical staff support. A successful ASP includes effective communication and acceptance of evidence-based recommendations, so that patient clinical outcomes will be optimized. PMID:27098167

  6. NASA technology utilization program: The small business market

    Science.gov (United States)

    Vannoy, J. K.; Garcia-Otero, F.; Johnson, F. D.; Staskin, E.

    1980-01-01

    Technology transfer programs were studied to determine how they might be more useful to the small business community. The status, needs, and technology use patterns of small firms are reported. Small business problems and failures are considered. Innovation, capitalization, R and D, and market share problems are discussed. Pocket, captive, and new markets are summarized. Small manufacturers and technology acquisition are discussed, covering external and internal sources, and NASA technology. Small business and the technology utilization program are discussed, covering publications and industrial applications centers. Observations and recommendations include small business market development and contracting, and NASA management technology.

  7. Formerly Utilized Sites Remedial Action Program environmental compliance assessment checklists

    International Nuclear Information System (INIS)

    The purpose of the Environmental Compliance Assessment Program is to assess the compliance of Formerly Utilized Site Remedial Action Program (FUSRAP) sites with applicable environmental regulations and Department of Energy (DOE) Orders. The mission is to identify, assess, and decontaminate sites utilized during the 1940s, 1950s, and 1960s to process and store uranium and thorium ores in support of the Manhattan Engineer District and the Atomic Energy Commission. To conduct the FUSRAP environmental compliance assessment, checklists were developed that outline audit procedures to determine the compliance status of the site. The checklists are divided in four groups to correspond to these regulatory areas: Hazardous Waste Management, PCB Management, Air Emissions, and Water Discharges

  8. Drug utilization pattern of antimicrobial agents in an outpatient department of otorhinolaryngology in a tertiary care hospital: a prospective, cross-sectional study

    Directory of Open Access Journals (Sweden)

    Sanket B. Sathiya

    2016-02-01

    Conclusions: Our study shows some rational prescription patterns like less utilization of antimicrobials in ENT infections and were according to standard treatment guideline. The results of this study will be useful in future for making standard treatment guidelines. It also promotes the rational prescription and rational use of drugs. [Int J Basic Clin Pharmacol 2016; 5(1.000: 65-69

  9. Electric Utility Transmission and Distribution Line Engineering Program

    Energy Technology Data Exchange (ETDEWEB)

    Peter McKenny

    2010-08-31

    Economic development in the United States depends on a reliable and affordable power supply. The nation will need well educated engineers to design a modern, safe, secure, and reliable power grid for our future needs. An anticipated shortage of qualified engineers has caused considerable concern in many professional circles, and various steps are being taken nationwide to alleviate the potential shortage and ensure the North American power system's reliability, and our world-wide economic competitiveness. To help provide a well-educated and trained workforce which can sustain and modernize the nation's power grid, Gonzaga University's School of Engineering and Applied Science has established a five-course (15-credit hour) Certificate Program in Transmission and Distribution (T&D) Engineering. The program has been specifically designed to provide working utility engineering professionals with on-line access to advanced engineering courses which cover modern design practice with an industry-focused theoretical foundation. A total of twelve courses have been developed to-date and students may select any five in their area of interest for the T&D Certificate. As each course is developed and taught by a team of experienced engineers (from public and private utilities, consultants, and industry suppliers), students are provided a unique opportunity to interact directly with different industry experts over the eight weeks of each course. Course material incorporates advanced aspects of civil, electrical, and mechanical engineering disciplines that apply to power system design and are appropriate for graduate engineers. As such, target students for the certificate program include: (1) recent graduates with a Bachelor of Science Degree in an engineering field (civil, mechanical, electrical, etc.); (2) senior engineers moving from other fields to the utility industry (i.e. paper industry to utility engineering or project management positions); and (3) regular

  10. Evaluation of an antimicrobial resistance monitoring program for campylobacter in poultry by simulation

    DEFF Research Database (Denmark)

    Regula, G.; Wong, Danilo Lo Fo; Ledergerber, U.;

    2005-01-01

    An ideal national resistance monitoring program should deliver a precise estimate of the resistance situation for a given combination of bacteria and antimicrobial at a low cost. To achieve this, decisions need to be made on the number of samples to be collected at each of different possible...... sampling points. Existing methods of sample size calculation can not be used to solve this problem, because sampling decisions do not only depend on the prevalence of resistance and sensitivity and specificity of resistance testing, but also on the prevalence of the bacteria, and test characteristics...... of isolation of these bacteria. Our aim was to develop a stochastic simulation model that optimized a national resistance monitoring program, taking multi-stage sampling, imperfect sensitivity and specificity of diagnostic tests, and cost-effectiveness considerations into account. The process of resistance...

  11. Utility-based optimization of phase II/III programs.

    Science.gov (United States)

    Kirchner, Marietta; Kieser, Meinhard; Götte, Heiko; Schüler, Armin

    2016-01-30

    Phase II and phase III trials play a crucial role in drug development programs. They are costly and time consuming and, because of high failure rates in late development stages, at the same time risky investments. Commonly, sample size calculation of phase III is based on the treatment effect observed in phase II. Therefore, planning of phases II and III can be linked. The performance of the phase II/III program crucially depends on the allocation of the resources to phases II and III by appropriate choice of the sample size and the rule applied to decide whether to stop the program after phase II or to proceed. We present methods for a program-wise phase II/III planning that aim at determining optimal phase II sample sizes and go/no-go decisions in a time-to-event setting. Optimization is based on a utility function that takes into account (fixed and variable) costs of the drug development program and potential gains after successful launch. The proposed methods are illustrated by application to a variety of scenarios typically met in oncology drug development.

  12. Utilization review of psychiatric care: building a program that works.

    Science.gov (United States)

    Wilson, P A

    1988-01-01

    Since the early 1970s the federal government, private insurers, and employers have searched for ways to control health care costs. In 1972, Congress, dissatisfied with hospitals' utilization review efforts under the Medicare program created Professional Standards Review Organizations (PSROs). Ten years later when the Medicare reimbursement system underwent radical changes, the utilization review system remained more or less intact but had its name changed to Professional Review Organizations (PROs). The insurance industry has developed and employed, with varying levels of success, several cost-saving tactics, including deductibles and copayments for specialized care, limitation of benefits by diagnosis or facility type, exclusion of specific disorders, inclusion of dollar limits, pre-payment claims review for specific types of service, and post-payment review with retroactive denial of claims. Case management is the latest development in the ever-widening search to put a lid on health care costs. These attempts to measure the effectiveness of care vis a vis the dollar spent for it have been especially difficult for psychiatry, a less measurable science than other fields of medicine. Because psychiatry straddles the disciplines of sociology, psychology, and medicine, it is not easily understood. Inadequate documentation of care, a paucity of outcome studies, and confidentiality issues all combine to make utilization review particularly difficult in psychiatry. This paper will describe a collaboration between Blue Cross and Blue Shield of Maryland and four private psychiatric hospitals in the state that resulted in a workable, effective utilization review program acceptable to providers, payers, and patients. PMID:10318292

  13. Patron perception and utilization of an embedded librarian program

    Science.gov (United States)

    Blake, Lindsay; Ballance, Darra; Davies, Kathy; Gaines, Julie K.; Mears, Kim; Shipman, Peter; Connolly-Brown, Maryska; Burchfield, Vicki

    2016-01-01

    Objective The study measured the perceived value of an academic library's embedded librarian service model. Setting The study took place at the health sciences campuses of a research institution. Methods A web-based survey was distributed that asked respondents a series of questions about their utilization of and satisfaction with embedded librarians and services. Results Over 58% of respondents reported being aware of their embedded librarians, and 95% of these were satisfied with provided services. Conclusions The overall satisfaction with services was encouraging, but awareness of the embedded program was low, suggesting an overall need for marketing of services. PMID:27366124

  14. Pennsylvania state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and State levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  15. Maryland state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and State levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Maryland. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  16. Massachusetts state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Massachusetts. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.

  17. Illinois State information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Illinois. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  18. Pennsylvania state information handbook formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  19. Oregon state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  20. California state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of California. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations

  1. Massachusetts state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Massachusetts. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations

  2. Maryland State information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Handbook Series Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Maryland. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  3. California state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of California. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations.

  4. Iowa state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-02-09

    This volume is one of a series produced under contract with the DOE, By Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Iowa. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.

  5. Oregon state information handbook formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administater, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  6. Iowa state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, By Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Iowa. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations

  7. Illinois state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Illinois. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full text of relevant statutes and regulations

  8. Maryland State information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Handbook Series Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Maryland. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  9. Pennsylvania state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and State levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Pennsylvania. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  10. Oregon state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  11. Oregon state information handbook formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administater, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Oregon. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  12. Ohio state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    1981-02-09

    This volume is one of a series produced under contract with the DOE, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of Ohio. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; the full test of relevant statutes and regulations.

  13. Description of the Formerly Utilized Sites Remedial Action Program

    International Nuclear Information System (INIS)

    The background and the results to date of the Department of Energy program to identify and evaluate the radiological conditions at sites formerly utilized by the Corps of Engineers' Manhattan Engineer District (MED) and the US Atomic Energy Commission (AEC) are summarized. The sites of concern were federally, privately, and institutionally owned and were used primarily for research, processing, and storage of uranium and thorium ores, concentrates, or residues. Some sites were subsequently released for other purposes without radiological restriction. Surveys have been conducted since 1974 to document radiological conditions at such sites. Based on radiological surveys, sites are identified in this document that require, or are projected to require, remedial action to remove potential restrictions on the use of the property due to the presence of residual low-level radioactive contamination. Specific recommendations for each site will result from more detailed environmental and engineering surveys to be conducted at those sites and, if necessary, an environmental impact assessment or environmental impact statement will be prepared. Section 3.0 describes the current standards and guidelines now being used to conduct remedial actions. Current authority of the US Department of Energy (DOE) to proceed with remedial actions and the new authority required are summarized. A plan to implement the Formerly Utilized Sites Remedial Action Program (FUSRAP) in accordance with the new authority is presented, including the objectives, scope, general approach, and a summary schedule. Key issues affecting schedule and cost are discussed

  14. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... More in Antimicrobial Resistance National Antimicrobial Resistance Monitoring System About NARMS Bacteria (NARMS) NARMS at Work Reports ... Emergency Preparedness International Programs News & Events Training & Continuing Education Inspections & Compliance Federal, State & Local Officials Consumers Health ...

  15. Federal government information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations

  16. Federal government information handbook formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains: a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant Federal statutes and regulations

  17. Federal government information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the Federal Government. It contains a summary of the organization and responsibilities of agencies within the executive branch of the Federal government which may be relevant to FUSRAP activities; a brief summary of relevant Federal statutes and regulations; a description of the structure of the US Congress, identification of the officers, relevant committees and committee chairmen; a description of the Federal legislative process; a summary of legislation enacted and considered in the recently-adjourned 96th Congress; a description of the Federal budgetary process; a summary of the Carter Administration's comprehensive radioactive waste management program; and excerpts from the text of relevant federal statutes and regulations.

  18. Perfil da utilização de antimicrobianos em um hospital privado The profile of antimicrobial utilization in a private hospital

    Directory of Open Access Journals (Sweden)

    Fernanda d'Athayde Rodrigues

    2010-06-01

    Full Text Available Os antimicrobianos são um dos grupos de medicamentos mais prescritos nos hospitais e que causam uma grande preocupação quanto à adequação do seu uso. Descreveu-se o perfil dos antimicrobianos utilizados num hospital privado do interior do Rio Grande do Sul, analisando a quantidade consumida de cada antimicrobiano. Foram analisadas todas as prescrições de pacientes que utilizaram antimicrobianos enquanto internados no período de março a junho de 2006. O consumo dos antimicrobianos foi expresso em dose diária definida (DDD por 100 leitos-dia. As análises de utilização de antimicrobianos foram feitas em geral e estratificadas por grupos de idade e por clínicas médicas. Durante o período em estudo, a prevalência do uso de antimicrobianos foi de 52,4% (IC95% 49,2-55,7. As cefalosporinas foram as mais utilizadas (43,4%, seguidas das penicilinas (16,3%, fluorquinolonas (13,0% e aminoglicosídeos (9,7%. O alto consumo de antimicrobianos durante o período em estudo é resultado da ausência de uma política de controle dos medicamentos prescritos no hospital e da falta de protocolos de uso de antimicrobianos. Para que haja um controle do consumo de antimicrobianos, os hospitais devem assumir uma política de vigilância sobre as prescrições deste grupo de medicamentos.The antimicrobials are one of the groups of the most prescribed drugs in hospitals and which cause a great concern for the suitability of their use. The profile of the antimicrobials utilized in a private hospital in the countryside of Rio Grande do Sul State was described and the quantity of each antimicrobial consumed was analyzed. All the prescriptions of patients who utilized antimicrobials while they were hospitalized in the period from March to June 2006 were analyzed. The antimicrobial consumption was expressed in Defined Daily Dose (DDD in 100 day-beds. The antimicrobial utilization analysis were done generally speaking and divided by age groups and by medical

  19. The Program Administrator Cost of Saved Energy for Utility Customer-Funded Energy Efficiency Programs

    Energy Technology Data Exchange (ETDEWEB)

    Billingsley, Megan A.; Hoffman, Ian M.; Stuart, Elizabeth; Schiller, Steven R.; Goldman, Charles A.; LaCommare, Kristina

    2014-03-19

    End-use energy efficiency is increasingly being relied upon as a resource for meeting electricity and natural gas utility system needs within the United States. There is a direct connection between the maturation of energy efficiency as a resource and the need for consistent, high-quality data and reporting of efficiency program costs and impacts. To support this effort, LBNL initiated the Cost of Saved Energy Project (CSE Project) and created a Demand-Side Management (DSM) Program Impacts Database to provide a resource for policy makers, regulators, and the efficiency industry as a whole. This study is the first technical report of the LBNL CSE Project and provides an overview of the project scope, approach, and initial findings, including: • Providing a proof of concept that the program-level cost and savings data can be collected, organized, and analyzed in a systematic fashion; • Presenting initial program, sector, and portfolio level results for the program administrator CSE for a recent time period (2009-2011); and • Encouraging state and regional entities to establish common reporting definitions and formats that would make the collection and comparison of CSE data more reliable. The LBNL DSM Program Impacts Database includes the program results reported to state regulators by more than 100 program administrators in 31 states, primarily for the years 2009–2011. In total, we have compiled cost and energy savings data on more than 1,700 programs over one or more program-years for a total of more than 4,000 program-years’ worth of data, providing a rich dataset for analyses. We use the information to report costs-per-unit of electricity and natural gas savings for utility customer-funded, end-use energy efficiency programs. The program administrator CSE values are presented at national, state, and regional levels by market sector (e.g., commercial, industrial, residential) and by program type (e.g., residential whole home programs, commercial new

  20. Renewable Energy Price-Stability Benefits in Utility Green Power Programs. 36 pp

    Energy Technology Data Exchange (ETDEWEB)

    Bird, Lori A. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cory, Karlynn S. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Swezey, Blair G. [Applied Materials, Santa Clara, CA (United States)

    2008-08-01

    This paper examines utility experiences when offering the fixed-price benefits of renewable energy in green pricing programs, including the methods utilized and the impact on program participation. It focuses primarily on utility green pricing programs in states that have not undergone electric industry restructuring.

  1. Renewable Energy Price-Stability Benefits in Utility Green Power Programs

    Energy Technology Data Exchange (ETDEWEB)

    Bird, L. A.; Cory, K. S.; Swezey, B. G.

    2008-08-01

    This paper examines utility experiences when offering the fixed-price benefits of renewable energy in green pricing programs, including the methods utilized and the impact on program participation. It focuses primarily on utility green pricing programs in states that have not undergone electric industry restructuring.

  2. Missouri State information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Missouri. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature chairmen, and a summary of recent relevant legislative action; a description of the organization and structure of local governments affected by remedial action at the St. Louis area sites; a summary of relevant local ordinances and regulations; an identification of relevant public interest groups; a list of radio stations, television stations, and newspapers that provide public information to the St. Louis area or to Jefferson City; and the full text of relevant statutes and regulations.

  3. Missouri state information handbook formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and rgulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Missouri. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; a description of the organization and structure of local governments affected by remedial action at the St. Louis area sites; a summary of relevant local ordinances and regulations; an identification of relevant public interest groups; a list of radio stations, television stations and newspapers that provide public information to the St. Louis area or to Jefferson City; and the full text of relevant statutes and regulations

  4. Embossed radiography utilizing an image-shifting subtraction program

    Science.gov (United States)

    Sato, Eiichi; Osawa, Akihiro; Matsukiyo, Hiroshi; Enomoto, Toshiyuki; Watanabe, Manabu; Takahashi, Kiyomi; Sato, Shigehiro; Ogawa, Akira; Onagawa, Jun

    2010-07-01

    We developed an image-shifting subtraction program and carried out embossed radiography (ER) utilizing single- and dual-energy subtractions. In particular, dual-energy subtraction was carried out to decrease the absorption contrast of unnecessary regions. The contrast resolution of a target region was increased using the subtraction program and a linear-contrast system in a flat panel detector (FPD). The X-ray generator had a 100 μm-focus tube, and the subtractions were performed at tube voltages of 40 and 70 kV, a tube current of 0.50 mA, and an X-ray exposure time of 5.0 s. ER was achieved with cohesion imaging using the FPD with pixel sizes of 48×48 μm 2, and the shifting dimension of an object in the horizontal and vertical directions ranged from 48 to 96 μm. At a shifting distance of 96 μm, the spatial resolutions in the horizontal and vertical directions measured with a lead test chart were both 83 μm. In ER of animal phantoms, we obtained high-contrast embossed images of fine bones, gadolinium oxide particles in blood vessels, iodine-based microspheres in coronary arteries approximately 100 μm in diameter.

  5. Missouri State information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Missouri. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature chairmen, and a summary of recent relevant legislative action; a description of the organization and structure of local governments affected by remedial action at the St. Louis area sites; a summary of relevant local ordinances and regulations; an identification of relevant public interest groups; a list of radio stations, television stations, and newspapers that provide public information to the St. Louis area or to Jefferson City; and the full text of relevant statutes and regulations

  6. 42 CFR 456.4 - Responsibility for monitoring the utilization control program.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Responsibility for monitoring the utilization... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL General Provisions § 456.4 Responsibility for monitoring the utilization control program. (a) The agency must— (1)...

  7. 42 CFR 456.652 - Requirements for an effective utilization control program.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Requirements for an effective utilization control... HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Penalty for Failure To Make a Satisfactory Showing of an Effective Institutional Utilization Control Program §...

  8. 42 CFR 456.3 - Statewide surveillance and utilization control program.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Statewide surveillance and utilization control... AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL General Provisions § 456.3 Statewide surveillance and utilization control program. The Medicaid agency must implement...

  9. Magnification Embossed Radiography Utilizing Image-Shifting Subtraction Program

    Science.gov (United States)

    Osawa, Akihiro; Watanabe, Manabu; Sato, Eiichi; Matsukiyo, Hiroshi; Enomoto, Toshiyuki; Nagao, Jiro; Abderyim, Purkhet; Aizawa, Katsuo; Tanaka, Etsuro; Mori, Hidezo; Kawai, Toshiaki; Ogawa, Akira; Takahashi, Kiyomi; Sato, Shigehiro; Onagawa, Jun

    2010-03-01

    We developed an image-shifting subtraction program and carried out magnification embossed radiography (MER) utilizing single- and dual-energy subtractions. In particular, dual-energy subtraction was carried out to decrease the absorption contrast of unnecessary regions. The contrast resolution of the target region was increased by the use of subtraction software and a linear-contrast system in a flat-panel detector (FPD). The X-ray generator had a 100-µm-focus tube, and the subtractions were performed at tube voltages of 40 and 70 kV, a tube current of 0.50 mA, and an X-ray exposure time of 5.0 s. MER images with threefold magnification were obtained using the FPD with a pixel size of 48×48 µm2, and the shifting dimensions of the imaged object in the horizontal and vertical directions ranged from 48 to 192 µm. At a shifting distance ranging from 48 to 144 µm, the spatial resolutions in the horizontal and vertical directions measured with a lead test chart were both 50 µm. In the MER of nonliving animals, we obtained high-contrast embossed images of fine bones, gadolinium oxide particles in blood vessels, and iodine-based microspheres in coronary arteries of approximately 100 µm diameter.

  10. Magnification embossed radiography utilizing image-shifting subtraction program

    International Nuclear Information System (INIS)

    We developed an image-shifting subtraction program and carried out magnification embossed radiography (MER) utilizing single-and dual-energy subtractions. In particular, dual-energy subtraction was carried out to decrease the absorption contrast of unnecessary regions. The contrast resolution of the target region was increased by the use of subtraction software and a linear-contrast system in a flat-panel detector (FPD). The X-ray generator had a 100-μm-focus tube, and the subtractions were performed at tube voltages of 40 and 70 kV, a tube current of 0.50 mA, and an X-ray exposure time of 5.0 s. MER images with threefold magnification were obtained using the FPD with a pixel size of 48 x 48 μm2, and the shifting dimensions of the imaged object in the horizontal and vertical directions ranged from 48 to 192 μm. At a shifting distance ranging from 48 to 144 μm, the spatial resolutions in the horizontal and vertical directions measured with a lead test chart were both 50 μm. In the MER of nonliving animals, we obtained high-contrast embossed Images of fine bones, gadolinium oxide particles in blood vessels, and iodine-based microspheres in coronary arteries of approximately 100 μm diameter. (author)

  11. ECUT (Energy Conversion and Utilization Technologies Program). Biocatalysis Project

    Science.gov (United States)

    1986-07-01

    Presented are the FY 1985 accomplishments, activities, and planned research efforts of the Biocatalysis Project of the U.S. Department of Energy, Energy Conversion and Utilization Technologies (ECUT) Program. The Project's technical activities were organized as follows: In the Molecular Modeling and Applied Genetics work element, research focused on (1) modeling and simulation studies to establish the physiological basis of high temperature tolerance in a selected enzyme and the catalytic mechanisms of three species of another enzyme, and (2) determining the degree of plasmid amplification and stability of several DNA bacterial strains. In the Bioprocess Engineering work element, research focused on (1) studies of plasmid propagation and the generation of models, (2) developing methods for preparing immobilized biocatalyst beads, and (3) developing an enzyme encapsulation method. In the Process Design and Analysis work element, research focused on (1) further refinement of a test case simulation of the economics and energy efficiency of alternative biocatalyzed production processes, (2) developing a candidate bioprocess to determine the potential for reduced energy consumption and facility/operating costs, and (3) a techno-economic assessment of potential advancements in microbial ammonia production.

  12. Implementation of solar-reflective surfaces: Materials and utility programs

    Energy Technology Data Exchange (ETDEWEB)

    Bretz, S.; Akbari, H.; Rosenfeld, A.; Taha, H.

    1992-06-01

    This report focuses on implementation issues for using solar-reflective surfaces to cool urban heat islands, with specific examples for Sacramento, California. Advantages of solar-reflective surfaces for reducing energy use are: (1) they are cost-effective if albedo is increased during routine maintenance; (2) the energy savings coincide with peak demand for power; (3) there are positive effects on environmental quality; and (4) the white materials have a long service life. Important considerations when choosing materials for mitigating heat islands are identified as albedo, emissivity, durability, cost, pollution and appearance. There is a potential for increasing urban albedo in Sacramento by an additional 18%. Of residential roofs, we estimate that asphalt shingle and modified bitumen cover the largest area, and that built-up roofing and modified bitumen cover the largest area of commercial buildings. For all of these roof types, albedo may be increased at the time of re-roofing without any additional cost. When a roof is repaired, a solar-reflective roof coating may be applied to significantly increase albedo and extend the life of the root Although a coating may be cost-effective if applied to a new roof following installation or to an older roof following repair, it is not cost-effective if the coating is applied only to save energy. Solar-reflective pavement may be cost-effective if the albedo change is included in the routine resurfacing schedule. Cost-effective options for producing light-colored pavement may include: (1) asphalt concrete, if white aggregate is locally available; (2) concrete overlays; and (3) newly developed white binders and aggregate. Another option may be hot-rolled asphalt, with white chippings. Utilities could promote solar-reflective surfaces through advertisement, educational programs and cost-sharing of road resurfacing.

  13. Drug utilization pattern of antimicrobial drugs in intensive care unit of a tertiary care hospital attached with a medical college

    Directory of Open Access Journals (Sweden)

    Rutvij Hedamba

    2016-02-01

    Conclusions: Despite of limitations of present study it gives important conclusion about how antimicrobial drugs are used in GGGH ICU. This information can be used for improvement of current treatment strategies. [Int J Basic Clin Pharmacol 2016; 5(1.000: 169-172

  14. Utilization of Low-Cost Ellagitannins for Ellagic Acid Production and Antimicrobial Phenolics Enhancing By Aspergillus awamorii and Aspergillus oryzae

    International Nuclear Information System (INIS)

    Three fungal strains, Aspergillus awamorii A9, Aspergillus awamorii A23 and Aspergillus oryzae O2, were selected out of ten fungal strains for their activeness in converting pomegranate peel ellagitannins into ellagic acid. When pomegranate peel was fermented by Aspergillus awamorii A9, the highest yields of ellagic acid (7.93±0.23 mg/g solid substrate) and total soluble phenolics (14.61±0.36 mg/g solid substrate) were produced at 5 and 10 days of incubation, respectively. Also, blue berry pomace, red grape pomace, strawberry pomace were evaluated as low cost ellagitannin sources for ellagic acid and soluble phenolics production. The antimicrobial activity of soluble phenolics extracted from fermented pomegranate peel and strawberry pomace was tested against two food-borne pathogens (Escherichia coli and Salmonella typhimurium). This study also revealed that 3 kGy enhanced the activity of antimicrobial phenolics

  15. Time series analysis as a tool to predict the impact of antimicrobial restriction in antibiotic stewardship programs using the example of multidrug-resistant Pseudomonas aeruginosa.

    Science.gov (United States)

    Willmann, Matthias; Marschal, Matthias; Hölzl, Florian; Schröppel, Klaus; Autenrieth, Ingo B; Peter, Silke

    2013-04-01

    The association between antimicrobial consumption and resistance in nonfermentative Gram-negative bacteria is well-known. Antimicrobial restriction, implemented in clinical routines by antibiotic stewardship programs (ASPs), is considered a means to reduce resistance rates. Whether and how antimicrobial restriction can accomplish this goal is still unknown though. This leads to an element of uncertainty when designing strategies for ASPs. From January 2002 until December 2011, an observational study was performed at the University Hospital Tübingen, Tübingen, Germany, to investigate the association between antimicrobial use and resistance rates in Pseudomonas aeruginosa. Transfer function models were used to determine such associations and to simulate antimicrobial restriction strategies. Various positive associations between antimicrobial consumption and resistance were observed in our setting. Surprisingly, impact estimations of different antimicrobial restriction strategies revealed relatively low intervention expenses to effectively attenuate the observed increase in resistance. For example, a simulated intervention of an annual 4% reduction in the use of meropenem over 3 years from 2009 until 2011 yielded a 62.5% attenuation (95% confidence interval, 15% to 110%) in the rising trend of multidrug-resistant Pseudomonas aeruginosa (three- and four-class-resistant P. aeruginosa [34MRGN-PA]). Time series analysis models derived from past data may be a tool to predict the outcome of antimicrobial restriction strategies, and could be used to design ASPs.

  16. Putting a utility's design change program in TOPFORM

    International Nuclear Information System (INIS)

    Duke Power Co. is unique among investor-owned electric utilities in that it designs and builds its generating stations. It has used this do-it-yourself approach in the completion of seven nuclear units, which provide over half of the company's net generation. Design changes to these operating nuclear units are handled in house, and the utility recently implemented a set of enhancements called TOPFORM. This paper describes the design change process enhancements made by Duke's design engineering department

  17. Monte Carlo programs and other utilities for high energy physics

    International Nuclear Information System (INIS)

    The Software Standards and Documentation Group of the Workshop on Physics and Detector Simulation for SSC Experiments has compiled a list of physics generators, detector simulations, and related programs. This is not meant to be an exhaustive compilation, nor is any judgment made about program quality; it is a starting point or a more complete bibliography. Where possible we have included an author and source for the code. References for most programs are in the final section

  18. The effects of utility DSM programs on electricity costs and prices

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.

    1991-11-01

    More and more US utilities are running more and larger demand-side management (DSM) programs. Assessing the cost-effectiveness of these programs raises difficult questions for utilities and their regulators. Should these programs aim to minimize the total cost of providing electric-energy services or should they minimize the price of electricity This study offers quantitative estimates on the tradeoffs between total costs and electricity prices. This study uses a dynamic model to assess the effects of energy-efficiency programs on utility revenues, total resource costs, electricity prices, and electricity consumption for the period 1990 to 2010. These DSM programs are assessed under alternative scenarios. In these cases, fossil-fuel prices, load growth, the amount of excess capacity the utility has in 1990, planned retirements of power plants, the financial treatment of DSM programs, and the costs of energy- efficient programs vary. These analyses are conducted for three utilities: a base'' that is typical of US utilities; a surplus'' utility that has excess capacity, few planned retirements, and slow growth in fossil-fuel prices and incomes; and a deficit'' utility that has little excess capacity, many planned retirements, and rapid growth in fossil-fuel prices and incomes. 28 refs.

  19. The effects of utility DSM programs on electricity costs and prices

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.

    1991-11-01

    More and more US utilities are running more and larger demand-side management (DSM) programs. Assessing the cost-effectiveness of these programs raises difficult questions for utilities and their regulators. Should these programs aim to minimize the total cost of providing electric-energy services or should they minimize the price of electricity? This study offers quantitative estimates on the tradeoffs between total costs and electricity prices. This study uses a dynamic model to assess the effects of energy-efficiency programs on utility revenues, total resource costs, electricity prices, and electricity consumption for the period 1990 to 2010. These DSM programs are assessed under alternative scenarios. In these cases, fossil-fuel prices, load growth, the amount of excess capacity the utility has in 1990, planned retirements of power plants, the financial treatment of DSM programs, and the costs of energy- efficient programs vary. These analyses are conducted for three utilities: a ``base`` that is typical of US utilities; a ``surplus`` utility that has excess capacity, few planned retirements, and slow growth in fossil-fuel prices and incomes; and a ``deficit`` utility that has little excess capacity, many planned retirements, and rapid growth in fossil-fuel prices and incomes. 28 refs.

  20. General utility computer programs for nuclear structure experiments

    International Nuclear Information System (INIS)

    The Nuclear codes package contains several theory programs which allow the calculation of many quantities needed in nuclear structure experiments. These codes were initially created to be run on Vax Machines. Therefore, many errors result at their compilation on Linux Machines. We fixed these errors and verified the result with input parameters that generate known output quantities. The following programs are available on the Linux network at the Department of Nuclear Physics: 1. BASS -Program to calculate fusion barriers and the limiting angular momentum for complete fusion of heavy ions, using the Bass model; 2. BM1BE2 -Program to calculate the ratio of the reduced transition probabilities: B(M1;I→I-1)/B(E2;I→I-2) = 2/2 and the mixing ratio of ΔI = 1 transitions: δ = 0.799· Eγ(MeV)· /. The Program uses the semi-classical formalism of Doenau and Frauendorf. The extension to multi-quasiparticle structures follows Radford's prescription; 3. CLEBSCH -Program to calculate the Clebsch-Gordan coefficients: ; 4. CLEB - Calculates only the following Clebsch-Gordan coefficients: and ; 5. DEDX - Based on an old Oak Ridge code, this program calculates stopping powers and ranges. It works with all chemical elements, plus the compounds ISOBUTANE and MYLAR; 6. EPSBET - The program makes conversion between Nilsson epsilon deformations and Warsaw betas, i.e. shape defined in terms of epsilons will be expanded in terms of betas. Originally written by W. Nazarewicz; 7. GOSTOP - This program allows the calculation of electronic and nuclear stopping powers. Data for the stopper material density are taken from the American Institute of Physics handbook; 8. QUAD - Program which extracts β2 and ε2 values from a given quadrupole moment Q0; 9. STIME Program to calculate stopping times for ions in materials; 10. WU - Program to calculate the reduced electromagnetic transition rates B(EL), B(ML) and the ratios B(EL)/B(EL)W and B(ML)/B(ML)W (in Weiskopf units). (authors)

  1. Line Program Environmental Management Audit: Formerly Utilized Sites Remedial Action Program

    International Nuclear Information System (INIS)

    This report documents the results of the Line Program Environmental Management Audit completed for the Formerly Utilized Sites Remedial Action Program (FUSRAP). During this Audit, activities and records were reviewed and personnel interviewed at Oak Ridge, Tennessee. Additionally, since FUSRAP falls under the responsibility of the Office of the Assistant Secretary for Environmental Restoration and Waste Management, selected individuals from this office were interviewed in Washington, DC and Germantown, Maryland. The onsite portion of the FUSRAP Audit was conducted from March 16 through 27, 1992, by the US Department of Energy's Office of Environmental Audit (EH-24) located within the Office of the Assistant Secretary for Environment, Safety and Health (EH-1). The scope of the FUSRAP Line Program Environmental Management Audit was comprehensive and included all areas of environmental management with the exception of the National Environmental Policy Act (NEPA). Since the subject of compliance with and implementation of the requirements of NEPA is the responsibility of the DOE Headquarters Office of NEPA Oversight, management issues pertaining to NEPA were not investigated as part of this Audit

  2. Electric-utility DSM-program costs and effects, 1991 to 2001

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.

    1993-05-01

    For the past three years (1989, 1990, and 1991), all US electric utilities that sell more than 120 GWh/year have been required to report to the Energy Information Administration data on their demand-side management (DSM) programs. These data provide a rich and uniquely comprehensive picture of electric-utility DSM programs in the United States. Altogether, 890 utilities (of about 3250 in the United States) ran DSM programs in 1991; of these, 439 sold more than 120 GWh and reported details on their DSM programs. These 439 utilities represent more than 80% of total US electricity sales and revenues. Altogether, these utilities spent almost $1.8 billion on DSM programs in 1991, equal to 1.0% of total utility revenues that year. In return for these (and prior-year) expenditures, utility DSM programs cut potential peak demand by 26,700 MW (4.8% of the national total) and cut annual electricity use by 23,300 GWh (0.9% of the national total). These 1991 numbers represent substantial increases over the 1989 and 1990 numbers on utility DSM programs. Specifically, utility DSM expenditures doubled, energy savings increased by almost 50%, and demand reductions increased by one-third between 1989 and 1991. Utilities differed enormously in their DSM-program expenditures and effects. Almost 12% of the reporting utilities spent more than 2% of total revenues on DSM programs in 1991, while almost 60% spent less than 0.5% of revenues on DSM. Utility estimates of future DSM-program expenditures and benefits show continuing growth. By the year 2001, US utilities expect to spend 1.2% of revenues on DSM and to cut demand by 8.8% and annual sales by 2.7%. Here, too, expectations vary by region. Utilities in the West and Northwest plan to spend more than 2% of revenues on DSM that year, while utilities in the Mid-Atlantic, Midwest, Southwest, Central, and North Central regions plan to spend less than 1% of revenues on DSM.

  3. The cost and performance of utility commercial lighting programs. A report from the Database on Energy Efficiency Programs (DEEP) project

    Energy Technology Data Exchange (ETDEWEB)

    Eto, J.; Vine, E.; Shown, L.; Sonnenblick, R.; Payne, C. [Lawrence Berkeley Lab., CA (United States). Energy and Environment Div.

    1994-05-01

    The objective of the Database on Energy Efficiency Programs (DEEP) is to document the measured cost and performance of utility-sponsored, energy-efficiency, demand-side management (DSM) programs. Consistent documentation of DSM programs is a challenging goal because of problems with data consistency, evaluation methodologies, and data reporting formats that continue to limit the usefulness and comparability of individual program results. This first DEEP report investigates the results of 20 recent commercial lighting DSM programs. The report, unlike previous reports of its kind, compares the DSM definitions and methodologies that each utility uses to compute costs and energy savings and then makes adjustments to standardize reported program results. All 20 programs were judged cost-effective when compared to avoided costs in their local areas. At an average cost of 3.9{cents}/kWh, however, utility-sponsored energy efficiency programs are not ``too cheap to meter.`` While it is generally agreed upon that utilities must take active measures to minimize the costs and rate impacts of DSM programs, the authors believe that these activities will be facilitated by industry adoption of standard definitions and reporting formats, so that the best program designs can be readily identified and adopted.

  4. Florida state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the federal and state levels, the pertinent programs they administer, each affected state legislature, and current federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Florida. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  5. Florida state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-02-27

    This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the federal and state levels, the pertinent programs they administer, each affected state legislature, and current federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of Florida. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  6. Interactions between Energy Efficiency Programs funded under the Recovery Act and Utility Customer-Funded Energy Efficiency Programs

    Energy Technology Data Exchange (ETDEWEB)

    Goldman, Charles A.; Stuart, Elizabeth; Hoffman, Ian; Fuller, Merrian C.; Billingsley, Megan A.

    2011-02-25

    Since the spring of 2009, billions of federal dollars have been allocated to state and local governments as grants for energy efficiency and renewable energy projects and programs. The scale of this American Reinvestment and Recovery Act (ARRA) funding, focused on 'shovel-ready' projects to create and retain jobs, is unprecedented. Thousands of newly funded players - cities, counties, states, and tribes - and thousands of programs and projects are entering the existing landscape of energy efficiency programs for the first time or expanding their reach. The nation's experience base with energy efficiency is growing enormously, fed by federal dollars and driven by broader objectives than saving energy alone. State and local officials made countless choices in developing portfolios of ARRA-funded energy efficiency programs and deciding how their programs would relate to existing efficiency programs funded by utility customers. Those choices are worth examining as bellwethers of a future world where there may be multiple program administrators and funding sources in many states. What are the opportunities and challenges of this new environment? What short- and long-term impacts will this large, infusion of funds have on utility customer-funded programs; for example, on infrastructure for delivering energy efficiency services or on customer willingness to invest in energy efficiency? To what extent has the attribution of energy savings been a critical issue, especially where administrators of utility customer-funded energy efficiency programs have performance or shareholder incentives? Do the new ARRA-funded energy efficiency programs provide insights on roles or activities that are particularly well-suited to state and local program administrators vs. administrators or implementers of utility customer-funded programs? The answers could have important implications for the future of U.S. energy efficiency. This report focuses on a selected set of ARRA

  7. Economics and utility energy-efficiency programs: Energy-efficient manufactured housing

    Energy Technology Data Exchange (ETDEWEB)

    Lee, A.D.; Onisko, S.A.

    1992-10-01

    As utilities investigate ways to implement conservation programs, the differences between customer and utility economic perspectives become more important. Because utilities bear the cost of new energy sources, energy efficiency investments that are cost-effective to them may not be cost-effective to their customers who pay average energy prices and have different economic parameters. The Bonneville Power Administration (BPA) and other parties in the Pacific Northwest have initiated an innovative manufactured (mobile) home energy conservation program. Because manufactured homes are regulated by the Department of Housing and Urban Development (HUD), are exempt from local regulations, and comprise up to 50% of new housing starts in some parts of the United States, utilities and energy planners need to find creative ways to make the economics of manufactured housing energy-efficiency investments more attractive. Differences between the economic criteria and perspectives of consumers and utilities can be used to design energy-efficiency programs. This paper discusses life-cycle cost (LCC) analysis as a framework for highlighting these differences and examines other economic criteria. It then presents information from the Pacific Northwest manufactured housing program to illustrate the application of this framework to a real-world program. Findings from this program should,be of interest to utility and government planners who are designing innovative energy-efficiency programs.

  8. ECUT (Energy Conversion and Utilization Technologies) program: Biocatalysis Project

    Science.gov (United States)

    1988-03-01

    Fiscal year 1987 research activities and accomplishments for the Biocatalysis Project of the U.S. Department of Energy, Energy Conversion and Utilization Technologies (ECUT) Division are presented. The project's technical activities were organized into three work elements. The Molecular Modeling and Applied Genetics work element includes modeling and simulation studies to verify a dynamic model of the enzyme carboxypeptidase; plasmid stabilization by chromosomal integration; growth and stability characteristics of plasmid-containing cells; and determination of optional production parameters for hyper-production of polyphenol oxidase. The Bioprocess Engineering work element supports efforts in novel bioreactor concepts that are likely to lead to substantially higher levels of reactor productivity, product yields, and lower separation energetics. The Bioprocess Design and Assessment work element attempts to develop procedures (via user-friendly computer software) for assessing the economics and energetics of a given biocatalyst process.

  9. ECUT (Energy Conversion and Utilization Technologies) program: Biocatalysis Project

    Science.gov (United States)

    1988-01-01

    Fiscal year 1987 research activities and accomplishments for the Biocatalysis Project of the U.S. Department of Energy, Energy Conversion and Utilization Technologies (ECUT) Division are presented. The project's technical activities were organized into three work elements. The Molecular Modeling and Applied Genetics work element includes modeling and simulation studies to verify a dynamic model of the enzyme carboxypeptidase; plasmid stabilization by chromosomal integration; growth and stability characteristics of plasmid-containing cells; and determination of optional production parameters for hyper-production of polyphenol oxidase. The Bioprocess Engineering work element supports efforts in novel bioreactor concepts that are likely to lead to substantially higher levels of reactor productivity, product yields, and lower separation energetics. The Bioprocess Design and Assessment work element attempts to develop procedures (via user-friendly computer software) for assessing the economics and energetics of a given biocatalyst process.

  10. [The role of antimicrobial stewardship programs in the control of bacterial resistance].

    Science.gov (United States)

    Pasquau, J; Sadyrbaeva, S; De Jesús, S E; Hidalgo-Tenorio, C

    2016-09-01

    In order to improve infection prognosis and reduce the existing microbial resistance problem (a challenge similar to that of climate change), a higher implication of the Administration, an increased level of social awareness and the development of specific corporate networks, including the pharmaceutical industry, is needed. However, we must first consolidate Antimicrobial Stewardship Programmes with experts who seek to improve antibiotic therapy effectivity in severe infections and to reduce global antibiotic exposure. PMID:27608314

  11. NJOY-UTILITIES-EIR, Utility Program EPLOTR, CPLOTR, SEPR, COMBR, DECAYR for NJOY

    International Nuclear Information System (INIS)

    1 - Description of program or function: EPLOTR is designed to plot evaluated cross sections in the ENDF/B format. The program plots cross sections, angular distributions, energy distributions and other parameters. CPLOTR compares ENDF/B formatted data from two separate input files. The program produces a series of comparative plots containing the standard cross section and second cross section and/or the ratio of the second cross section to the first cross section. SEPR: Select data for one or more temperatures from a file. COMBR: - Combine optionally ENDF, PENDF or GENDF Binary Cross Section files given in ENDF/B-IV or ENDF/B-V format and select the format of the output file - Copy optionally ENDF, PENDF or GENDF Binary Cross Section files or change their format from ENDF/B-IV to ENDF/B-V format or from ENDF/B-V to ENDF/B-IV. DECAYR: Prints radioactive Decay and fission yield data from MF=8. 2 - Method of solution: In plotting cross sections, EPLOTR reads all sections of File 3 and divides them into five categories: - total, elastic, capture, fission, and total inelastic; - total inelastic, discrete levels, and continuum; - (n,2n), (n,3n), (n,n' charged particle); - (n, charged particle); - nu(total and delayed), mu, and xi. Each category is plotted separately. If a cross section is given for one or more reactions in any given category, all cross sections of that category are plotted on a single frame, spanning the energy range from 0.01 eV or the minimum threshold up to the maximum energy tabulated. More detailed plots can be obtained by using the zoom commands. For CPLOTR, reactions are considered to be comparable if they have the same (ZA,MT) combination. The reactions compared will be plotted if they differ by a user-specified allowable difference. 3 - Restrictions on the complexity of the problem: EPLOTR uses only the ENDF/B BCD format and skips all sections except nu(E) (total and delayed) as well as Files 4 and 5. Thus the program may be used to plot cross

  12. Validation of the MCNP-ORIGEN coupled utility program (MOCUP)

    International Nuclear Information System (INIS)

    The purpose of this work was to validate the MOCUP program for burn-up analysis. Two well-documented benchmarking problems were used to validate MOCUP itself and the application way. One benchmark consists of three PWR pin-cell burn-up cases. The other benchmark is a fast reactor (burner) burn-up problem. From the comparisons of our MOCUP results by using appropriate program parameters with those obtained from measurement and/or other computer codes, it has been concluded that: (a) with few exceptions, the MOCUP results of isotopic compositions fall within the range of those calculated by different codes; (b) MOCUP results for the actinide concentration are in agreement with the measurement values to within 11% (for most of the actinides, the deviations are less than 5%) and for all fission products studied, the deviations are less than 10%, except for 149Sm; and (c) the MOCUP predictions of reactivity change with burn-up are in good agreement with the reported values

  13. Do Subsidized Health Programs in Armenia Increase Utilization among the Poor?

    OpenAIRE

    Angel-Urdinola, Diego; Jain, Shweta

    2008-01-01

    This article analyzes the extent to which the Basic Benefit Package (BBP), a subsidized health program in Armenia, increases utilization and affordability of outpatient health care among the poor. We find that beneficiaries of the BBP pay approximately 45 % less in fees for doctor visits (and display 36 % higher outpatient utilization rates) than eligible users not receiving the BBP. However, even among BBP beneficiaries the level of outpatient health care utilization remains low. This occurs...

  14. 76 FR 30904 - Rural Utilities Service Telecommunications Loan and Loan Guarantee Program

    Science.gov (United States)

    2011-05-27

    ... Rural Utilities Service Rural Utilities Service Telecommunications Loan and Loan Guarantee Program... telecommunications systems, equipment and services. The List of Materials historically has been a very useful tool in... to advancing state-of-the-art telecommunications technologies, consistent with our commitment to...

  15. The demand-side management program development process: A utility perspective

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, A.K. [Oak Ridge National Lab., TN (United States); Yourstone, N.E. [Yourstone (Evelin), Albuquerque, NM (United States)

    1992-03-01

    This report describes an aspect of DSM that has received little attention, namely, how utilities develop DSM programs. The selection of utilities to study purposely was biased in favor of those with reputations for being experienced DSM program developers so as to optimize the chances to obtain detailed information. The DSM planning process is affected by organizational factors and external influences: (1) the location of the demand-side planning department within the utility; (2) the demand-side planning group`s functional responsibilities; (3) upper management participation in the DSM program development process; and (4) the organizational relationship between (or, separation of) supply-side and demand-side planning. Organizational factors reflect utilities` views of DSM programs and thus can affect the adoption of a technology- or customer-oriented approach. Despite repeated claims of the uniqueness of the demand- side planning process and its resistance to standardization, two general approaches to program development were discerned, namely technology- or customer-orientation. Although utilities consider customer related and technological factors in their DSM program development process, utilities can be differentiated by their emphasis on one or the other approach. 25 refs.

  16. The demand-side management program development process: A utility perspective

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, A.K. (Oak Ridge National Lab., TN (United States)); Yourstone, N.E. (Yourstone (Evelin), Albuquerque, NM (United States))

    1992-03-01

    This report describes an aspect of DSM that has received little attention, namely, how utilities develop DSM programs. The selection of utilities to study purposely was biased in favor of those with reputations for being experienced DSM program developers so as to optimize the chances to obtain detailed information. The DSM planning process is affected by organizational factors and external influences: (1) the location of the demand-side planning department within the utility; (2) the demand-side planning group's functional responsibilities; (3) upper management participation in the DSM program development process; and (4) the organizational relationship between (or, separation of) supply-side and demand-side planning. Organizational factors reflect utilities' views of DSM programs and thus can affect the adoption of a technology- or customer-oriented approach. Despite repeated claims of the uniqueness of the demand- side planning process and its resistance to standardization, two general approaches to program development were discerned, namely technology- or customer-orientation. Although utilities consider customer related and technological factors in their DSM program development process, utilities can be differentiated by their emphasis on one or the other approach. 25 refs.

  17. Improvements in Hanford TRU Program Utilizing Systems Modeling and Analyses

    International Nuclear Information System (INIS)

    Hanford's Transuranic (TRU) Program is responsible for certifying contact-handled (CH) TRU waste and shipping the certified waste to the Waste Isolation Pilot Plant (WIPP). Hanford's CH TRU waste includes material that is in retrievable storage as well as above ground storage, and newly generated waste. Certifying a typical container entails retrieving and then characterizing it (Non-Destructive Examination [NDE], Non-Destructive Assay [NDA], and Head Space Gas Sampling [HSG]), validating records (data review and reconciliation), and designating the container for a payload. The certified payload is then shipped to WIPP. Systems modeling and analysis techniques were applied to Hanford's TRU Program to help streamline the certification process and increase shipping rates. The modeling and analysis yields several benefits: - Maintains visibility on system performance and predicts downstream consequences of production issues. - Predicts future system performance with higher confidence, based on tracking past performance. - Applies speculation analyses to determine the impact of proposed changes (e.g., apparent shortage of feed should not be used as basis to reassign personnel if more feed is coming in the queue). - Positively identifies the appropriate queue for all containers (e.g., discovered several containers that were not actively being worked because they were in the wrong 'physical' location - method used previously for queuing up containers). - Identifies anomalies with the various data systems used to track inventory (e.g., dimensional differences for Standard Waste Boxes). A model of the TRU Program certification process was created using custom queries of the multiple databases for managing waste containers. The model was developed using a simplified process chart based on the expected path for a typical container. The process chart was augmented with the remediation path for containers that do not meet acceptance criteria for WIPP. Containers are sorted

  18. Utilization of Z Plant for Plowshare Program: Study 4

    Energy Technology Data Exchange (ETDEWEB)

    Bruns, L.E.

    1972-08-23

    The conversion of plutonium nitrate to metal, the fabrication and assembly of plutonium devices and the recovery of scrap by Atlantic Richfield Hanford Company (ARHCO) has been studied previously in support of the Plowshare Program. Previous studies and Plowshare Task Force meetings along with a teletype directive form the bases for Study 4. The major changes and additions in Study 4 as compared to Study 3 are: a complete new building is considered as an alternate to the use of existing facilities, waste storage tankage is added to capital costs, operating costs are divided into labor, material and overheads, and are based on 1976 dollars, depreciation on capital costing is excluded from unit costs, and features of the existing ARHCO plant coupled with comments on actual operating experience and further explanation of the flowsheets are added to the appendix.

  19. SSL Pricing and Efficacy Trend Analysis for Utility Program Planning

    Energy Technology Data Exchange (ETDEWEB)

    Tuenge, Jason R.

    2013-10-01

    An LED lamp or luminaire can generally be found that matches or exceeds the efficacy of benchmark technologies in a given product category, and LED products continue to expand into ever-higher lumen output niches. However, the price premium for LED continues to pose a barrier to adoption in many applications, in spite of expected savings from reduced energy use and maintenance. Other factors—such as dimmability and quality of light—can also present challenges. The appropriate type, timing, and magnitude of energy efficiency activities will vary from organization to organization based on local variables and the method of evaluation. A number of factors merit consideration when prioritizing activities for development. Category-specific projections for pricing and efficacy are provided herein to assist in efficiency program planning efforts.

  20. ECUT (Energy Conversion and Utilization Technologies) program: Biocatalysis project

    Science.gov (United States)

    Baresi, Larry

    1989-03-01

    The Annual Report presents the fiscal year (FY) 1988 research activities and accomplishments, for the Biocatalysis Project of the U.S. Department of Energy, Energy Conversion and Utilization Technologies (ECUT) Division. The ECUT Biocatalysis Project is managed by the Jet Propulsion Laboratory, California Institute of Technology. The Biocatalysis Project is a mission-oriented, applied research and exploratory development activity directed toward resolution of the major generic technical barriers that impede the development of biologically catalyzed commercial chemical production. The approach toward achieving project objectives involves an integrated participation of universities, industrial companies and government research laboratories. The Project's technical activities were organized into three work elements: (1) The Molecular Modeling and Applied Genetics work element includes research on modeling of biological systems, developing rigorous methods for the prediction of three-dimensional (tertiary) protein structure from the amino acid sequence (primary structure) for designing new biocatalysis, defining kinetic models of biocatalyst reactivity, and developing genetically engineered solutions to the generic technical barriers that preclude widespread application of biocatalysis. (2) The Bioprocess Engineering work element supports efforts in novel bioreactor concepts that are likely to lead to substantially higher levels of reactor productivity, product yields and lower separation energetics. Results of work within this work element will be used to establish the technical feasibility of critical bioprocess monitoring and control subsystems. (3) The Bioprocess Design and Assessment work element attempts to develop procedures (via user-friendly computer software) for assessing the energy-economics of biocatalyzed chemical production processes, and initiation of technology transfer for advanced bioprocesses.

  1. The community-based Health Extension Program significantly improved contraceptive utilization in West Gojjam Zone, Ethiopia

    Directory of Open Access Journals (Sweden)

    Yitayal M

    2014-05-01

    Full Text Available Mezgebu Yitayal,1 Yemane Berhane,2 Alemayehu Worku,3 Yigzaw Kebede11University of Gondar, Gondar, Ethiopia; 2Addis Continental Institute of Public Health, Addis Ababa, Ethiopia; 3Addis Ababa University, Addis Ababa, EthiopiaBackground: Ethiopia has implemented a nationwide primary health program at grassroots level (known as the Health Extension Program since 2003 to increase public access to basic health services. This study was conducted to assess whether households that fully implemented the Health Extension Program have improved current contraceptive use.Methods: A cross-sectional community-based survey was conducted to collect data from 1,320 mothers using a structured questionnaire. A multivariate logistic regression was used to identify the predictors of current contraceptive utilization. A propensity score analysis was used to determine the contribution of the Health Extension Program “model households” on current contraceptive utilization.Result: Mothers from households which fully benefited from the Health Extension Program (“model households” were 3.97 (adjusted odds ratio, 3.97; 95% confidence interval, 3.01–5.23 times more likely to use contraceptives compared with mothers from non-model households. Model household status contributed to 29.3% (t=7.08 of the increase in current contraceptive utilization.Conclusion: The Health Extension Program when implemented fully could help to increase the utilization of contraceptives in the rural community and improve family planning.Keywords: Health Extension Program, current contraceptive utilization

  2. Prediction of Antimicrobial Peptides Based on Sequence Alignment and Support Vector Machine-Pairwise Algorithm Utilizing LZ-Complexity

    Directory of Open Access Journals (Sweden)

    Xin Yi Ng

    2015-01-01

    Full Text Available This study concerns an attempt to establish a new method for predicting antimicrobial peptides (AMPs which are important to the immune system. Recently, researchers are interested in designing alternative drugs based on AMPs because they have found that a large number of bacterial strains have become resistant to available antibiotics. However, researchers have encountered obstacles in the AMPs designing process as experiments to extract AMPs from protein sequences are costly and require a long set-up time. Therefore, a computational tool for AMPs prediction is needed to resolve this problem. In this study, an integrated algorithm is newly introduced to predict AMPs by integrating sequence alignment and support vector machine- (SVM- LZ complexity pairwise algorithm. It was observed that, when all sequences in the training set are used, the sensitivity of the proposed algorithm is 95.28% in jackknife test and 87.59% in independent test, while the sensitivity obtained for jackknife test and independent test is 88.74% and 78.70%, respectively, when only the sequences that has less than 70% similarity are used. Applying the proposed algorithm may allow researchers to effectively predict AMPs from unknown protein peptide sequences with higher sensitivity.

  3. The Identification of Scientific Programs to Utilize the Space Environment

    Science.gov (United States)

    Kulacki, F. A.; Nerem, R. M.

    1976-01-01

    A program to identify and develop ideas for scientific experimentation on the long duration exposure facility (LDEF) was completed. Four research proposals were developed: (1) Ultra pure germanium gamma ray radiation detectors in the space environment, intended to develop and demonstrate an X-ray and gamma-ray spectroscopy system incorporating a temperature cyclable high-purity germanium detector and diode heat pipe cryogenic system for cooling, (2) growth, morphogenesis and metabolism of plant embryos in the zero-gravity environment, to investigate if the space environment induces mutations in the embryogenic cells so that mutants of commercial significance with desirable attributes may be obtained, (3) effect of zero gravity on the growth and pathogenicity of selected zoopathic fungi. It is possible that new kinds of treatment for candidiasis, and tichophytosis could eventuate from the results of the proposed studies, and (4) importance of gravity to survival strategies of small animals. Gravitational effects may be direct or mediate the selection of genetic variants that are preadapted to weightlessness.

  4. Cost-utility of a disease management program for patients with asthma

    NARCIS (Netherlands)

    Steuten, Lotte; Palmer, Stephen; Vrijhoef, Bert; Merode, van Frits; Spreeuwenberg, Cor; Severens, Hans

    2007-01-01

    Objectives: The long-term cost-utility of a disease management program (DMP) for adults with asthma was assessed compared to usual care. Methods: A DMP for patients with asthma has been developed and implemented in the region of Maastricht (The Netherlands). By integrating care, the program aims to

  5. The past, present, and future of U.S. utility demand-side management programs

    International Nuclear Information System (INIS)

    Demand-side management or DSM refers to active efforts by electric and gas utilities to modify customers' energy use patterns. The experience in the US shows that utilities, when provided with appropriate incentives, can provide a powerful stimulus to energy efficiency in the private sector. This paper describes the range and history of DSM programs offered by US electric utilities, with a focus on the political, economic, and regulatory events that have shaped their evolution. It also describes the changes these programs are undergoing as a result of US electricity industry restructuring. DSM programs began modestly in the 1970s in response to growing concerns about dependence on foreign sources of oil and environmental consequences of electricity generation, especially nuclear power. The foundation for the unique US partnership between government and utility interests can be traced first to the private-ownership structure of the vertically integrated electricity industry and second to the monopoly franchise granted by state regulators. Electricity industry restructuring calls into question both of these basic conditions, and thus the future of utility DSM programs for the public interest. Future policies guiding ratepayer-funded energy-efficiency DSM programs will need to pay close attention to the specific market objectives of the programs and to the balance between public and private interests

  6. The past, present, and future of U.S. utility demand-side management programs

    Energy Technology Data Exchange (ETDEWEB)

    Eto, J. [Lawrence Berkeley National Lab., CA (United States). Environmental Energy Technologies Div.

    1996-12-01

    Demand-side management or DSM refers to active efforts by electric and gas utilities to modify customers` energy use patterns. The experience in the US shows that utilities, when provided with appropriate incentives, can provide a powerful stimulus to energy efficiency in the private sector. This paper describes the range and history of DSM programs offered by US electric utilities, with a focus on the political, economic, and regulatory events that have shaped their evolution. It also describes the changes these programs are undergoing as a result of US electricity industry restructuring. DSM programs began modestly in the 1970s in response to growing concerns about dependence on foreign sources of oil and environmental consequences of electricity generation, especially nuclear power. The foundation for the unique US partnership between government and utility interests can be traced first to the private-ownership structure of the vertically integrated electricity industry and second to the monopoly franchise granted by state regulators. Electricity industry restructuring calls into question both of these basic conditions, and thus the future of utility DSM programs for the public interest. Future policies guiding ratepayer-funded energy-efficiency DSM programs will need to pay close attention to the specific market objectives of the programs and to the balance between public and private interests.

  7. Impact of Large Scale Energy Efficiency Programs On Consumer Tariffs and Utility Finances in India

    Energy Technology Data Exchange (ETDEWEB)

    Abhyankar, Nikit; Phadke, Amol

    2011-01-20

    Large-scale EE programs would modestly increase tariffs but reduce consumers' electricity bills significantly. However, the primary benefit of EE programs is a significant reduction in power shortages, which might make these programs politically acceptable even if tariffs increase. To increase political support, utilities could pursue programs that would result in minimal tariff increases. This can be achieved in four ways: (a) focus only on low-cost programs (such as replacing electric water heaters with gas water heaters); (b) sell power conserved through the EE program to the market at a price higher than the cost of peak power purchase; (c) focus on programs where a partial utility subsidy of incremental capital cost might work and (d) increase the number of participant consumers by offering a basket of EE programs to fit all consumer subcategories and tariff tiers. Large scale EE programs can result in consistently negative cash flows and significantly erode the utility's overall profitability. In case the utility is facing shortages, the cash flow is very sensitive to the marginal tariff of the unmet demand. This will have an important bearing on the choice of EE programs in Indian states where low-paying rural and agricultural consumers form the majority of the unmet demand. These findings clearly call for a flexible, sustainable solution to the cash-flow management issue. One option is to include a mechanism like FAC in the utility incentive mechanism. Another sustainable solution might be to have the net program cost and revenue loss built into utility's revenue requirement and thus into consumer tariffs up front. However, the latter approach requires institutionalization of EE as a resource. The utility incentive mechanisms would be able to address the utility disincentive of forgone long-run return but have a minor impact on consumer benefits. Fundamentally, providing incentives for EE programs to make them comparable to supply

  8. A scoping study on energy-efficiency market transformation by California Utility DSM Programs

    Energy Technology Data Exchange (ETDEWEB)

    Eto, J.; Prahl, R.; Schlegel, J.

    1996-07-01

    Market transformation has emerged as a central policy objective for future publicly-funded energy-efficiency programs in California. California Public Utilities Commission (CPUC) Decision 95-12-063 calls for public funding to shift to activities designed to transform the energy-efficiency market. The CPUC envisions that funding {open_quotes}would only be needed for specific and limited periods of time to cause the market to be transformed{close_quotes}. At the same time, the CPUC also acknowledges that {open_quotes}there are many definitions of market transformation{close_quotes} ... and does {open_quotes}not attempt to refine those definitions today{close_quotes}. We argue that a definition of market transformation is essential. The literature is now replete with definitions, and an operational definition is needed for the CPUC to decide on which programs should be supported with public funds. The CPUC decision initially indicated a preference for programs that do not provide financial assistance 4-efficiency programs that rely on financial assistance to customers. However, energy customers have traditionally accounted for a substantial portion of California utility`s DSM programs, so the CPUC`s direction to use ratepayer funds to support programs that will transform the market raises critical questions about how to analyze what has happened in order to plan effectively for the future: Which utility energy-efficiency programs, including those that provide financial assistance to customers, have had market transforming effects? To what extent do current regulatory rules and practices encourage or discourage utilities from running programs that are designed to transform the market? Should the rules and programs be modified, and, if so, how, to promote market transformation?

  9. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... use of antimicrobial drugs will result in the development of resistant strains of bacteria, complicating clinician's efforts ... Emergency Preparedness International Programs News & Events Training & Continuing Education Inspections & Compliance Federal, State & Local Officials Consumers Health ...

  10. Handbook of evaluation of utility DSM programs. [Demand-Side Management (DSM)

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.; Reed, J. (eds.); Bronfman, B.; Fitzpatrick, G.; Hicks, E.; Hirst, E.; Hoffman, M.; Keating, K.; Michaels, H.; Nadel, S.; Peters, J.; Reed, J.; Saxonis, W.; Schoen, A.; Violette, D.

    1991-12-01

    Program evaluation has become a central issue in the world of utility integrated resource planning. The DSM programs that utilities were operating to meet federal requirements or to improve customer relations are now becoming big business. DSM is being considered an important resource in a utility's portfolio of options. In the last five years, the amount of money that utilities have invested in DSM has grown exponentially in most regulatory jurisdictions. Market analysts are now talking about DSM being a $30 billion industry by the end of the decade. If the large volume of DSM-program investments was not enough to highlight the importance of evaluation, then the introduction of regulatory incentives has really focused the spotlight. This handbook was developed through a process that involved many of those people who represent the diverse constituencies of DSM-program evaluation. We have come to recognize the many technical disciplines that must be employed to evaluate DSM programs. An analysis might start out based on the principles of utility load research to find out what happened, but a combination of engineering and statistical methods must be used to triangulate'' an estimate of what would have happened without the program. The difference, of course, is that elusive but prized result of evaluation: what happened as the direct result of the DSM program. Technical performance of DSM measures is not the sole determinant of the answer, either. We also recognize the importance of such behavioral attributes of DSM as persistence and free ridership. Finally, DSM evaluation is meaningless without attention to planning an approach, communicating results to relevant decision-makers, and focusing as much on the process as the impacts of the program. These topics are all covered in this handbook.

  11. Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program.

    Science.gov (United States)

    Zhang, Yawei; Zhang, Feifei; Wang, Hui; Zhao, Chunjiang; Wang, Zhanwei; Cao, Bin; Du, Yan; Feng, Xianju; Hu, Yunjian; Hu, Bijie; Ji, Ping; Liu, Zhiyong; Liu, Yong; Liao, Wanzhen; Lu, Juan; Sun, Hongli; Wang, Zhongxin; Xu, Xiuli; Xu, Xuesong; Yang, Qing; Yu, Yunsong; Zhang, Rong; Zhuo, Chao

    2016-06-01

    This study investigated the antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolates causing adult community-acquired respiratory tract infections (CARTIs) in China. A multicentre resistance surveillance study (CARTIPS) investigating 1046 clinical isolates from 19 hospitals in China was conducted from 2013 to 2014. Based on the minimum inhibitory concentration (MIC) breakpoints of oral penicillin, the percentages of penicillin-resistant, penicillin-intermediate and penicillin-susceptible S. pneumoniae were 44.1%, 13.7%, and 42.2%, respectively. The rates of penicillin-non-susceptible S. pneumoniae ranged from 27.9% to 72.2% in different cities, with the highest rate in Nanchang. Macrolides, including azithromycin, clarithromycin and erythromycin, showed the lowest activities against S. pneumoniae isolates, with resistance rates of 90.5%, 92.2% and 93.0%, respectively. However, 98% of these strains were susceptible to levofloxacin and moxifloxacin. For H. influenzae isolates, most of the antimicrobials agents exhibited good activities. However, ampicillin and trimethoprim/sulfamethoxazole showed relatively lower activity against H. influenzae, with resistance rates of 35.0% and 54.4%, respectively. β-lactamase production rates amongst H. influenzae and M. catarrhalis were 31.0% and 87.1%, respectively. In addition, a total of 15 β-lactamase-negative ampicillin-resistant (BLNAR) strains identified in this study were resistant to ampicillin, amoxicillin/clavulanic acid, cefaclor and cefuroxime. Most of the antimicrobial agents showed excellent activity against M. catarrhalis, with susceptibility rates of >90%. The results from the current study confirmed the regional variations in antimicrobial susceptibility of major CARTI pathogens and provided some choices for the treatment of these organisms. Continuous national surveillance of the epidemiology of CARTIs is strongly warranted in China.

  12. Modeling the hydrologic and economic efficacy of stormwater utility credit programs for US single family residences

    Science.gov (United States)

    As regulatory pressure to reduce the environmental impact of urban stormwater intensifies, U.S. municipalities increasingly seek a dedicated source of funding for stormwater programs, such as a stormwater utility. In rare instances, single family residences are eligible for utili...

  13. 42 CFR 441.61 - Utilization of providers and coordination with related programs.

    Science.gov (United States)

    2010-10-01

    ... rehabilitation agencies, and Title V grantees (Maternal and Child Health/Crippled Children's Services). Further, the agency should make use of other public health, mental health, and education programs and related... 42 Public Health 4 2010-10-01 2010-10-01 false Utilization of providers and coordination...

  14. Demonstrating a small utility approach to demand-side program implementation

    International Nuclear Information System (INIS)

    The US DOE awarded a grant to the Burlington Electric Department (B.E.D.) to test a demand-side management (DSM) demonstration program designed to quickly save a significant amount of power with little disruption to the utility's customers or its normal operations. B.E.D. is a small municipal utility located in northern Vermont, with a lengthy history of successful DSM involvement. In our grant application, we proposed to develop a replicable program and approach to DSM that might be useful to other small utilities and to write a report to enable such replication. We believe that this DSM program and/or individual program components are replicable. This report is designed to allow other utilities interested in DSM to replicate this program or specific program design features to meet their DSM goals. We also wanted to use the opportunity of this grant to test the waters of residential heating fuel-switching. We hoped to test the application of one fuel-switching technology, and to benefit from the lessons learned in developing a full-scale DSM program for this end- use. To this end the pilot effort has been very successful. In the pilot pressure we installed direct-vent gas fired space heaters sized as supplemental heating units in 44 residences heated solely by electric resistance heat. We installed the gas space heating units at no cost to the owners or residents. We surveyed participating customers. The results of those surveys are included in this report and preliminary estimates of winter peak capacity load reductions are also noted in this report

  15. Demonstrating a small utility approach to demand-side program implementation

    Energy Technology Data Exchange (ETDEWEB)

    1991-10-01

    The US DOE awarded a grant to the Burlington Electric Department (B.E.D.) to test a demand-side management (DSM) demonstration program designed to quickly save a significant amount of power with little disruption to the utility's customers or its normal operations. B.E.D. is a small municipal utility located in northern Vermont, with a lengthy history of successful DSM involvement. In our grant application, we proposed to develop a replicable program and approach to DSM that might be useful to other small utilities and to write a report to enable such replication. We believe that this DSM program and/or individual program components are replicable. This report is designed to allow other utilities interested in DSM to replicate this program or specific program design features to meet their DSM goals. We also wanted to use the opportunity of this grant to test the waters of residential heating fuel-switching. We hoped to test the application of one fuel-switching technology, and to benefit from the lessons learned in developing a full-scale DSM program for this end- use. To this end the pilot effort has been very successful. In the pilot pressure we installed direct-vent gas fired space heaters sized as supplemental heating units in 44 residences heated solely by electric resistance heat. We installed the gas space heating units at no cost to the owners or residents. We surveyed participating customers. The results of those surveys are included in this report and preliminary estimates of winter peak capacity load reductions are also noted in this report.

  16. Financial Incentives, Workplace Wellness Program Participation, and Utilization of Health Care Services and Spending.

    Science.gov (United States)

    Fronstin, Paul; Roebuck, M Christopher

    2015-08-01

    This paper analyzes data from a large employer that enhanced financial incentives to encourage participation in its workplace wellness programs. It examines, first, the effect of financial incentives on wellness program participation, and second, it estimates the impact of wellness program participation on utilization of health care services and spending. The Patient Protection and Affordable Care Act of 2010 (PPACA) allows employers to provide financial incentives of as much as 30 percent of the total cost of coverage when tied to participation in a wellness program. Participation in health risk assessments (HRAs) increased by 50 percentage points among members of unions that bargained in the incentive, and increased 22 percentage points among non-union employees. Participation in the biometric screening program increased 55 percentage points when financial incentives were provided. Biometric screenings led to an average increase of 0.31 annual prescription drug fills, with related spending higher by $56 per member per year. Otherwise, no significant effects of participation in HRAs or biometric screenings on utilization of health care services and spending were found. The largest increase in medication utilization as a result of biometric screening was for statins, which are widely used to treat high cholesterol. This therapeutic class accounted for one-sixth of the overall increase in prescription drug utilization. Second were antidepressants, followed by ACE inhibitors (for hypertension), and thyroid hormones (for hypothyroidism). Biometric screening also led to significantly higher utilization of biologic response modifiers and immunosuppressants. These specialty medications are used to treat autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, and are relatively expensive compared with non-specialty medications. The added spending associated with the combined increase in fills of 0.02 was $27 per member per year--about one-half of the

  17. Improving enrollment and utilization of the Oportunidades program in Mexico could increase its effectiveness.

    Science.gov (United States)

    Leroy, Jef L; Vermandere, Heleen; Neufeld, Lynnette M; Bertozzi, Stefano M

    2008-03-01

    Oportunidades, Mexico's most important antipoverty program, currently with 5 million enrolled households in all regions of the country, has been shown to significantly contribute to improving the nutrition, health, and education of the poor. Because the program has used different enrollment strategies in rural and urban areas and has both obligatory (e.g., health and nutrition education) and nonobligatory components (e.g., nutrition supplements for children younger than 2 y of age), it provides an excellent opportunity to study program enrollment and utilization of different program components. In urban areas enrollment was more complex, and hence enrollment was much lower then in rural areas where the process was quasiautomatic, and nearly all eligible households enrolled. Enrollment in urban areas was not associated with having a child younger than 2 y of age. Utilization was notably higher with the obligatory than with the nonobligatory program components, illustrated by the inadequate consumption of the nutrition program's supplement as compared with near-universal compliance with well-baby visits. Innovative approaches, some of which are currently being tested, are needed to further increase the program's impact. PMID:18287380

  18. Utility DSM Programs from 1989 Through 1998: Continuation or Cross-Roads?

    Energy Technology Data Exchange (ETDEWEB)

    Hadley, S.

    1995-01-01

    Over the past five years, the Energy Information Administration (EIA) has been collecting data annually from US electric utilities on their demand-side management (DSM) programs, both current and projected. The latest data cover activities for 1993 and projections for 1994 and 1998. In 1993, 991 utilities operated DSM programs. That year, they spent $2.8 billion, a 13% increase over 1992 expenditures. These and earlier DSM programs saved 44,000 GWh of energy and reduced potential peak demand by 40,000 MW, 30% and 22% increases over the 1992 values, respectively. While some people predict the demise of electric-utility DSM programs, the data do not paint so bleak a picture. In most parts of the country, DSM programs grew in 1993 and utilities (as of Spring 1994) projected continued growth through 1998. Expenditures grew from 1.3% of revenues in 1992 to 1.5% in 1993, and are expected to grow 2.5% per year faster than inflation, which is equivalent to revenue growth. Thus, DSM spending is expected to stay constant at 1.5% of revenues through 1998. Because of the cumulative effect of DSM programs, energy savings are expected to grow from 1.2% of sales in 1992 to 1.6% in 1993 and 3.0% in 1998. Potential-peak reductions are expected to increase from 5.9% of peak demand in 1992 to 6.8% in 1993 and 8.9% in 1998. However, the growth in spending is not as rapid as the 8% annual real growth projected a year earlier. Actual expenditures in 1993 were 6.5% lower than projected early that year. Energy savings, on the other hand, were the same as projected earlier. Potential peak reductions were actually 9% higher than previously projected.

  19. State Clean Energy Policies Analysis: State, Utility, and Municipal Loan Programs

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, E.

    2010-05-01

    High initial costs can impede the deployment of clean energy technologies. Financing can reduce these costs. And, state, municipal, and utility-sponsored loan programs have emerged to fill the gap between clean energy technology financing needs and private sector lending. In general, public loan programs are more favorable to clean energy technologies than are those offered by traditional lending institutions; however, public loan programs address only the high up-front costs of clean energy systems, and the technology installed under these loan programs rarely supports clean energy production at levels that have a notable impact on the broader energy sector. This report discusses ways to increase the impact of these loan programs and suggests related policy design considerations.

  20. Antimicrobial Pesticides

    Science.gov (United States)

    ... US EPA US Environmental Protection Agency Search Search Pesticides Share Facebook Twitter Google+ Pinterest Contact Us You are here: EPA Home » Pesticides » Antimicrobial Pesticides Antimicrobial Pesticides News and Highlights Disinfection Hierarchy Workshop - October 7 ...

  1. Virginia Solar Pathways Project. Economic Study of Utility-Administered Solar Programs: Soft Costs, Community Solar, and Tax Normalization Considerations

    Energy Technology Data Exchange (ETDEWEB)

    Reiter, Emerson; Lowder, Travis; Mathur, Shivani; Mercer, Megan

    2016-06-23

    This report is an economic study of utility-administered solar programs in Virginia and the Southeast region at large. It includes an assessment of soft cost reduction opportunities, community solar programs, and the investment tax credit.

  2. RTMPL: A structured programming and documentation utility for real-time multiprocessor simulations

    Science.gov (United States)

    Arpasi, D. J.

    1984-01-01

    The NASA Lewis Research Center is developing and evaluating experimental hardware and software systems to help meet future needs for real time simulations of air-breathing propulsion systems. The Real Time Multiprocessor Simulator (RTMPS) project is aimed at developing a prototype simulator system that uses multiple microprocessors to achieve the desired computing speed and accuracy at relatively low cost. Software utilities are being developed to provide engineering-level programming and interactive operation of the simulator. Two major software development efforts were undertaken in the RTMPS project. A real time multiprocessor operating system was developed to provide for interactive operation of the simulator. The second effort was aimed at developing a structured, high-level, engineering-oriented programming language and translator that would facilitate the programming of the simulator. The Real Time Multiprocessor Programming Language (RTMPL) allows the user to describe simulation tasks for each processor in a straight-forward, structured manner. The RTMPL utility acts as an assembly language programmer, translating the high-level simulation description into time-efficient assembly language code for the processors. The utility sets up all of the interfaces between the simulator hardware, firmware, and operating system.

  3. Thorium utilization program. Quarterly progress report for the period ending May 31, 1977

    Energy Technology Data Exchange (ETDEWEB)

    1977-06-01

    Results of work performed under the National HTGR Fuel Recycle Program (also known as the Thorium Utilization Program) at General Atomic Company are presented. Results of work on this program prior to June 1974 were included in a quarterly series on the HTGR Base Program. The work reported includes the development of unit processes and equipment for reprocessing of High-Temperature Gas-Cooled Reactor (HTGR) fuel, the design and development of an integrated pilot line to demonstrate the head end of HTGR reprocessing using unirradiated fuel materials, and design work in support of Hot Engineering Tests (HET). Work is also described on trade-off studies concerning the required design of facilities and equipment for the large-scale recycle of HTGR fuels in order to guide the development activities for HTGR fuel recycle.

  4. Thorium utilization program quarterly progress report for the period ending February 29, 1976. [HTGR Fuel Recycle

    Energy Technology Data Exchange (ETDEWEB)

    1976-03-31

    This publication presents results of work performed under the National HTGR Fuel Recycle Program Thorium Utilization Program. The work reported includes the development of unit processes and equipment for reprocessing of HTGR fuel and the design and development of an integrated line to demonstrate the head end of HTGR reprocessing using unirradiated fuel materials. Work is also described on the development of the conceptual design of recycle facilities to identify the requirements of large-scale recycle of HTGR fuels and to incorporate the results of these studies in guidance of development activities for HTGR fuel recycle.

  5. Commercialization of PV-powered pumping systems for use in utility PV service programs. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    The project described in this report was a commercialization effort focused on cost-effective remote water pumping systems for use in utility-based photovoltaic (PV) service programs. The project combined a commercialization strategy tailored specifically for electric utilities with the development of a PV-powered pumping system that operates conventional ac pumps rather than relying on the more expensive and less reliable PV pumps on the market. By combining these two attributes, a project goal was established of creating sustained utility purchases of 250 PV-powered water pumping systems per year. The results of each of these tasks are presented in two parts contained in this Final Summary Report. The first part summarizes the results of the Photovoltaic Services Network (PSN) as a new business venture, while the second part summarizes the results of the Golden Photon system installations. Specifically, results and photographs from each of the system installations are presented in this latter part.

  6. Drug and alcohol abuse: the bases for employee assistance programs in the nuclear-utility industry

    Energy Technology Data Exchange (ETDEWEB)

    Radford, L.R.; Rankin, W.L.; Barnes, V.; McGuire, M.V.; Hope, A.M.

    1983-07-01

    This report describes the nature, prevalence, and trends of drug and alcohol abuse among members of the US adult population and among personnel in non-nuclear industries. Analogous data specific to the nuclear utility industry are not available, so these data were gathered in order to provide a basis for regulatory planning. The nature, prevalence, and trend inforamtion was gathered using a computerized literature, telephone discussions with experts, and interviews with employee assistance program representatives from the Seattle area. This report also evaluates the possible impacts that drugs and alcohol might have on nuclear-related job performance, based on currently available nuclear utility job descriptions and on the scientific literature regarding the impairing effects of drugs and alcohol on human performance. Employee assistance programs, which can be used to minimize or eliminate job performance decrements resulting from drug or alcohol abuse, are also discussed.

  7. Progress report Waste Resources Utilization Program period ending March 31, 1976

    International Nuclear Information System (INIS)

    This report describes the work on the Waste Resources Utilization Program for the quarter ending March 31, 1976. The purpose of this program is to develop technologies to utilize a 137Cs γ source to modify sewage sludge for safe application as a fertilizer or an animal feed supplement. Results are reported from studies in microbiology, virology, and physical-chemical studies. Determinations were made of inactivation rates for Salmonella species, coliforms, and fecal strep in sewage sludge when radiation and thermoradiation were applied while bubbling oxygen through the sludge. Virology studies were continued investigating virucidal characteristics of anaerobically digested sludge. Another area of study was the dewatering of sewage sludge to reduce the drying time of the sewage sludge in the drying beds. A centrifuge was also installed to dewater treated sludge to approximately 30 percent solids

  8. Recommended methods for evaluating the benefits of ECUT Program outputs. [Energy Conversion and Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Levine, L.O.; Winter, C.

    1986-03-01

    This study was conducted to define and develop techniques that could be used to assess the complete spectrum of positive effects resulting from the Energy Conversion and Utilization Technologies (ECUT) Program activities. These techniques could then be applied to measure the benefits from past ECUT outputs. In addition, the impact of future ECUT outputs could be assessed as part of an ongoing monitoring process, after sufficient time has elapsed to allow their impacts to develop.

  9. Dynamic Power Management for Portable Hybrid Power-Supply Systems Utilizing Approximate Dynamic Programming

    OpenAIRE

    Jooyoung Park; Gyo-Bum Chung; Jungdong Lim; Dongsu Yang

    2015-01-01

    Recently, the optimization of power flows in portable hybrid power-supply systems (HPSSs) has become an important issue with the advent of a variety of mobile systems and hybrid energy technologies. In this paper, a control strategy is considered for dynamically managing power flows in portable HPSSs employing batteries and supercapacitors. Our dynamic power management strategy utilizes the concept of approximate dynamic programming (ADP). ADP methods are important tools in the fields of stoc...

  10. In71, an Enterobacter cloacae blaVIM-1-carrying integron related to In70.2 from Italian Pseudomonas aeruginosa isolates: a SENTRY Antimicrobial Surveillance Program report.

    Science.gov (United States)

    Castanheira, Mariana; Sader, Hélio S; Jones, Ronald N; Debbia, Eugenio; Picão, Renata C; Gales, Ana C

    2007-01-01

    An Enterobacter cloacae strain showing decreased susceptibility to carbapenems was isolated from a blood culture of a patient hospitalized in Genoa, Italy, and screened for the presence of metallo-beta-lactamase (MBL) genes as part of the SENTRY Antimicrobial Surveillance Program. A bla(VIM-1)-carrying integron named In71 nearly identical to In70.2 reported in Pseudomonas aeruginosa strains isolated from various Italian cities since 2001 was identified in this strain. Interestingly, the In71 did not carry aadA1 nor possess the ISPa7 usually found in the P. aeruginosa integron In70.2. Mobilization of MBL genes from P. aeruginosa to members of the Enterobacteriaceae family is very worrisome because the rapid and wide dissemination of these potent antimicrobial resistance mechanisms could jeopardize the clinical use of carbapenems for the treatment of multidrug-resistant Enterobacteriaceae infections. PMID:17650966

  11. Radiological guidelines for application to DOE's Formerly Utilized Sites Remedial Action Program

    International Nuclear Information System (INIS)

    The US Department of Energy has implemented a program to evaluate and, where necessary, take action to protect the public from contamination at sites that were used in the past to process and/or store radioactive materials for the former US Army Corps of Engineers Manhattan Engineer District or the US Atomic Energy Commission. The program is identified as the Formerly Utilized Sites Remedial Action Program (FUSRAP). This document describes methods considered appropriate for the evaluation of health effects that might possible be caused by radioactive contamination at FUSRAP sites. This assessment methodology is applied to a typical site for the purposeof deriving guidelines for the cleanup of contaminated soil. Additional guidance is provided for planning site-specific remedial action that is consistent with the overall objectives of FUSRAP

  12. Effectiveness of a transitional home care program in reducing acute hospital utilization: a quasi-experimental study

    OpenAIRE

    Low, Lian Leng; Vasanwala, Farhad Fakhrudin; Ng, Lee Beng; Chen, Cynthia; Lee, Kheng Hock; Tan, Shu Yun

    2015-01-01

    Background Improving healthcare utilization is essential as health systems around the world grapple with the escalating demands for acute hospital resources. Evidence suggests that transitional care programs are effective to improve utilization of healthcare. However, the evidence for transitional care programs that enhance the home medical care model and provide multi-disciplinary patient-centered care is not well established. We evaluated if a transitional home care program operated by the ...

  13. Residential energy-consumption analysis utilizing the DOE-1 computer program

    Energy Technology Data Exchange (ETDEWEB)

    Arentsen, S K

    1979-04-01

    The DOE-1 computer program is used to examine energy consumption in a typical middle-class household in Cincinnati, Ohio. The program is used to compare energy consumption under different structural and environmental conditions, including various levels of insulation in the walls and ceiling, double and single glazing of windows, and thermostat setback schedules. In addition, the DOE-1 program is used to model the house under three energy distribution systems: a unit heater, a single-zone fan system with optional subzone reheat; and a unitary heat pump. A plant equipment simulation is performed to model the heating and cooling plant currently installed in the house. A simple economic analysis of life-cycle costs for the house is done utilizing the economic simulation portion of DOE-1. Utility bills over the past six years are analyzed to gain an actual energy-use profile for the house to compare with computer results. Results indicate that a 35% savings in heating load may be obtained with addition of proper amounts of insulation as compared with the house with no insulation. The installation of double glazing on windows may save close to 6% on heating load. Thermostat setbacks may result in savings of around 25% on energy consumed for heating. Similar results are achieved with regard to cooling load. Comparison of actual energy consumed by the household (from utility bills) with the computer results shows a 4.25% difference in values between the two. This small percent difference certainly strengthens the case for future use of computer programs in comparing construction alternatives and predicting building energy consumption.

  14. A LINEAR PROGRAMMING METHOD TO ENHANCE RESOURCE UTILIZATION CASE OF ETHIOPIAN APPAREL SECTOR

    Directory of Open Access Journals (Sweden)

    Gezahegn Tesfaye

    2016-06-01

    Full Text Available The Ethiopian industrial development strategy is characterized by export-led and labor intensive industrialization. The country is emerging as the most important investment destination in its apparel sector. Thought this sector is expected to generate more income from the export market, its export earnings remain trivial mainly due to the inefficient organizational resource utilization. One of the competent techniques that help companies to efficiently improve the use of their resources to increase their profit is linear programming. In apparel manufacturing firms, efficient use of materials such as fabrics and sewing threads and processing time at different stages of production as well as minimization of labor and materials cost are necessary to enhance their profitability. Cutting, sewing, and finishing operations deserve more attention for apparel process optimization. However, the issue of proper resource allocation remains an unsolved problem within the Ethiopian apparel industry. The aim of this research is to devise efficient resource utilization mechanism for Ethiopian apparel sector to improve their resource utilization and profitability, taking one of the garment factories engaged in the export market as a case study. Five types of products the company is currently producing, the amount of resources employed to produce each unit of the products, and the value of profit per unit from the sale of each products have been collected from the case company. The monthly availability of resources utilized and the monthly production volume of the five products have also been collected from the company. The data gathered was mathematically modeled using a linear programming technique, and solved using MS-Excel solver. The findings of the study depicts that all of the organizational resources are severely underutilized. This research proved that the resource utilization of the case company can be improved from 46.41% of the current resource

  15. Environmental assessment of a program to reduce oil and gas consumption by electric utilities

    Energy Technology Data Exchange (ETDEWEB)

    1980-03-01

    An environmental assessment is presented of a program aimed at reducing oil and gas consumption in electric utility power plants by the equivalent of approximately 10/sup 6/ barrels per day by 1990. The program would mandate the conversion of 45 power plants (approximately 21 GW) to coal and would provide financial incentives for the accelerated replacement of other existing oil- and gas-fired plants (estimated to be 30 GW) by new coal-fired plants or other acceptable alternatives. The report analyzes the air quality impacts of potential increases in sulfur dioxide, nitrogen oxides, and particulate matter emissions associated with the program. The assessment also considers potential solid waste, coal production and transportation, and public health and welfare impacts. The Coal and Electric Utilities Model (CEUM) of ICF, Incorporated, was used to generate the numerical data on which the assessment is based. Impacts are presented at the national and regional levels, with some discussion of possible local air quality effects of conversion of specific plants.

  16. Improving Secondary Practical Computer Skills: Logo Test Scores through Graphically Designed Computer Programs and Utilization of Multimedia and Technology.

    Science.gov (United States)

    Miller, Douglas S.

    The intent of this project was to improve test and programming scores of 9th through 12th grade students enrolled in the Practical Computer Skills: Logo course in a north central Florida high school. An implementation program that demonstrated teacher-designed graphical computer language Logo programs, utilized multimedia techniques, and used…

  17. Results from utility wind resource assessment programs in Nebraska, Colorado, and Arizona

    Energy Technology Data Exchange (ETDEWEB)

    Drapeau, C.L. [Global Energy Concepts, Inc., Bothell, WA (United States)

    1997-12-31

    Global Energy Concepts (GEC) has been retained by utilities in Colorado, Nebraska, and Arizona to site, install, and operate 21 wind monitoring stations as part of the Utility Wind Resource Assessment Program (U*WRAP). Preliminary results indicate wind speed averages at 40 meters (132 ft) of 6.5 - 7.4 m/s (14.5-16.5 mph) in Nebraska and 7.6 - 8.9 m/s (17.0-19.9 mph) in Colorado. The Arizona stations are not yet operational. This paper presents the history and current status of the 21 monitoring stations as well as preliminary data results. Information on wind speeds, wind direction, turbulence intensity, wind shear, frequency distribution, and data recovery rates are provided.

  18. New York state information handbook formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying our the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New York. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  19. New Mexico state information handbook formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Informaion Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  20. New Mexico state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  1. New Mexico state information handbook formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Informaion Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  2. New Mexico state information handbook: formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New Mexico. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  3. The ERDA thermionic program. [for nuclear propulsion and utility power plants

    Science.gov (United States)

    Newby, G. A.

    1975-01-01

    A rationale for increased Federal support of thermionic research is considered and the objectives and milestones of the thermionic program of the U.S. Energy Research and Development Administration (ERDA) are examined. The ERDA program is to provide very high specific power systems needed for planned future NASA nuclear electric propulsion missions. Another objective is the enhancement of the overall thermal conversion efficiency of the present utility power plants from approximately 35% to 50% or more. Attention is given to key problem areas, taking into account inadequate analytical tools, the reduction of the plasma arc-drop losses, aspects of hot shell materials development, and the coordination of the participating groups programmatic activities.

  4. New York state information handbook: formerly utilized sites remedial action program

    International Nuclear Information System (INIS)

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New York. It contains a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations

  5. New York state information handbook formerly utilized sites remedial action program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-12-31

    This volume is one of a series produced under contract with the DOE, by Politech Corporation to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying our the Formerly Utilized Sites Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the State of New York. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations.

  6. Antimicrobial stewardship in small animal veterinary practice

    DEFF Research Database (Denmark)

    Guardabassi, Luca; Prescott, John F

    2015-01-01

    Despite the increasing recognition of the critical role for antimicrobial stewardship in preventing the spread of multidrug-resistant bacteria, examples of effective antimicrobial stewardship programs are rare in small animal veterinary practice. This article highlights the basic requirements...... for establishing stewardship programs at the clinic level. The authors provide suggestions and approaches to overcome constraints and to move from theoretic concepts toward implementation of effective antimicrobial stewardship programs in small animal clinics....

  7. Tigecycline antimicrobial activity tested against clinical bacteria from Latin American medical centres: results from SENTRY Antimicrobial Surveillance Program (2011-2014).

    Science.gov (United States)

    Sader, Helio S; Castanheira, Mariana; Farrell, David J; Flamm, Robert K; Mendes, Rodrigo E; Jones, Ronald N

    2016-08-01

    Bacterial organisms (n = 13,494) were consecutively collected in 2011-2014 from 21 Latin American medical centres (11 nations). Antimicrobial susceptibility was determined by broth microdilution at a central laboratory. Tigecycline was very active against Gram-positive organisms, with MIC50/90 values of 0.06/0.06 µg/mL for Staphylococcus aureus (n = 2878), 0.06/0.12 µg/mL for coagulase-negative staphylococci (n = 880), 0.06/0.06 µg/mL for enterococci (n = 708) and ≤0.03/≤0.03-0.06 µg/mL for streptococci (n = 1352). All Gram-positive species exhibited 100.0% susceptibility (FDA and/or EUCAST criteria), except for Streptococcus pneumoniae (99.8% susceptible). The S. aureus oxacillin resistance rate varied from 28.0% (Brazil) to 55.0% (Argentina), and the overall vancomycin resistance rate was 15.5% (Enterococcus faecium, 50.3%; and Enterococcus faecalis, 2.3%). The E. faecium vancomycin resistance rate varied from a low (26.3%) in Argentina to a high (71.7%) in Brazil. Against Enterobacteriaceae (n = 4543), tigecycline MIC50/90 values were 0.25/1 µg/mL; 98.3% and 94.2% of strains were considered susceptible according to FDA and EUCAST breakpoints, respectively. Overall, 37.7% and 57.3% of Escherichia coli and Klebsiella pneumoniae exhibited the CLSI ESBL screening phenotype. The highest CLSI ESBL screening phenotype rates among E. coli and Klebsiella spp. strains were observed for isolates collected from Mexico (69.9%) and Chile (69.9%), respectively. Occurrence of carbapenem-resistant Enterobacteriaceae was substantially higher in Brazil (9.0%) and Argentina (6.3%) compared with Chile and Mexico (0.4-0.7%). Tigecycline was also active against Acinetobacter spp. (MIC50/90, 1/2 µg/mL; 92.3/72.1% inhibited at ≤2/≤1 µg/mL) and Stenotrophomonas maltophilia (MIC50/90, 0.5/2 µg/mL; 91.5/83.0% inhibited at ≤2/≤1 µg/mL). PMID:27291285

  8. A python-based docking program utilizing a receptor bound ligand shape: PythDock.

    Science.gov (United States)

    Chung, Jae Yoon; Cho, Seung Joo; Hah, Jung-Mi

    2011-09-01

    PythDock is a heuristic docking program that uses Python programming language with a simple scoring function and a population based search engine. The scoring function considers electrostatic and dispersion/repulsion terms. The search engine utilizes a particle swarm optimization algorithm. A grid potential map is generated using the shape information of a bound ligand within the active site. Therefore, the searching area is more relevant to the ligand binding. To evaluate the docking performance of PythDock, two well-known docking programs (AutoDock and DOCK) were also used with the same data. The accuracy of docked results were measured by the difference of the ligand structure between x-ray structure, and docked pose, i.e., average root mean squared deviation values of the bound ligand were compared for fourteen protein-ligand complexes. Since the number of ligands' rotational flexibility is an important factor affecting the accuracy of a docking, the data set was chosen to have various degrees of flexibility. Although PythDock has a scoring function simpler than those of other programs (AutoDock and DOCK), our results showed that PythDock predicted more accurate poses than both AutoDock4.2 and DOCK6.2. This indicates that PythDock could be a useful tool to study ligand-receptor interactions and could also be beneficial in structure based drug design.

  9. Methodological comparisons for antimicrobial resistance surveillance in feedlot cattle

    OpenAIRE

    Katharine M Benedict; Gow, Sheryl P.; Checkley, Sylvia; Booker, Calvin W.; McAllister, Tim A; Morley, Paul S.

    2013-01-01

    Background The purpose of this study was to objectively compare methodological approaches that might be utilized in designing an antimicrobial resistance (AMR) surveillance program in beef feedlot cattle. Specifically, four separate comparisons were made to investigate their potential impact on estimates for prevalence of AMR. These included investigating potential differences between 2 different susceptibility testing methods (broth microdilution and disc diffusion), between 2 different targ...

  10. Re-utilization by '' Stud Welding'' of capsules charpy-V belonged to surveillance programs

    International Nuclear Information System (INIS)

    The perspectives of nuclear plants life extension that are approximating to their end of design life compels to make new surveillance programs. The re-utilization of specimens belonging to surveillance capsules already tested in these new surveillance programs seems be a solution worldwide accepted. The two possible re-utilization processes of this irradiated material are: Subsized specimens and Reconstitution. While the first alternative (Subsized specimens) outlines serious problems for apply the results, the reconstitution eliminates this problem, since the resulting specimens after of the reconstruction procedure would be of the same dimensions that the original. The reconstruction process involves welds, and therefore it has associated the specific problems of this type of joints. Furthermore, by be tried to material irradiated with certain degree of internal damage, that is the variable to evaluate, requires that the heat contribution to the piece not originate local thermal treatments that alter its mechanical qualities. In this work has been followed the evolution by the variables of the weld process and their influence on the quality by the union from metallographic al point of view as well as mechanical for a weld procedure by Stud Welding. The principal objective is to optimize said parameters to assure a good mechanical continuity, without detriment of the microstructural characteristics of the original material. To verify this last have been accomplished with metallographical tests, temperature profile, hardness and will be carried out also Charpy tests. (Author)

  11. Utility of N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides as precursors for synthesis of new functionalized 1,3,4-thiadiazoles with potential antimicrobial activity

    Directory of Open Access Journals (Sweden)

    Abdou O. Abdelhamid

    2015-11-01

    Full Text Available Starting from N-aryl 2-aroylhydrazono-propanehydrazonoyl chlorides, a series of new functionalized 1,3,4-thiadiazoles were prepared. The structures of the compounds prepared were confirmed by both elemental and spectral analyses as well as by alternate synthesis. The mechanisms of the studied reactions are outlined. The antimicrobial activities of the compounds prepared were screened and the results showed that most of such compounds exhibit considerable activities.

  12. A Method of Determination of an Acquisition Program in Order to Maximize the Total Utility Using Linear Programming in Integer Numbers

    Directory of Open Access Journals (Sweden)

    Alin Cristian Ioan

    2010-03-01

    Full Text Available This paper solves in a different way the problem of maximization of the total utility using the linear programming in integer numbers. The author uses the diofantic equations (equations in integers numbers and after a decomposing in different cases, he obtains the maximal utility.

  13. Lessons Learned: A review of utility experience with conservation and load management programs for commercial and industrial customers

    Energy Technology Data Exchange (ETDEWEB)

    Nadel, S.

    1990-10-01

    This report examines utility experience with conservation and load management (C LM) programs of commercial and industrial (C I) customers in order to summarize the lessons learned from program experiences to date and what these teach us about how to operate successful programs in the future. This analysis was motivated by a desire to learn about programs which achieve high participation rates and high electricity savings while remaining cost effective. Also, we wanted to review the very latest experiences with innovative program approaches -- approaches that might prove useful to utilities as they scale up their C LM activities. Specific objectives of this phase of the study are threefold: (1) To disseminate information on utility C LM experience to a nationwide audience. (2) To review current New York State utility programs and make suggestions on how these programs can be improved. (3) To collect data for the final phase of the American Council for an Energy-Efficient Economy/New York State Energy Research and Development Authority project, which will examine the savings that are achievable if C LM programs are pushed to the limit'' of current knowledge on how to structure and run cost-effective C LM programs. 19 tabs.

  14. Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA.

    Directory of Open Access Journals (Sweden)

    Alejandro Dorado-García

    Full Text Available With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA. Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07 and animals (p = 0.12 in first cycle. These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend.

  15. Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA.

    Science.gov (United States)

    Dorado-García, Alejandro; Graveland, Haitske; Bos, Marian E H; Verstappen, Koen M; Van Cleef, Brigitte A G L; Kluytmans, Jan A J W; Wagenaar, Jaap A; Heederik, Dick J J

    2015-01-01

    With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU) in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA). Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C)) was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07) and animals (p = 0.12 in first cycle)). These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend. PMID:26305895

  16. Development of beam utilization and application technology - Development of KOMAC user program

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Kang Ok; Heo, Jin Young [Korea Accelerator and Plasma Association, Seoul (Korea); Chung, Kie Hyung; Nam, Yong Un [Seoul National University, Seoul (Korea); Noh, Seung Jung [Dankook University, Seoul (Korea)

    1999-04-01

    To develop cooperations for the construction of the KOMAC (Korea Multi-purpose Accelerator Complex) and to maximize the operation efficiency and rate, foreign user programs for large accelerator facilities, which are well organized and already settled down as a result of many year's or decades' operation experience, were surveyed and the user related status of the KOMAC class accelerators under construction was also surveyed. The survey was conducted through conference attendances, visits, interviews, seminar openings, or internet searches. In addition, the utilization as well as application areas of the KOMAC are categorized and four surveys of user's requests and markets were conducted via e-mails, mails, telephones, or visits. An internet home page and seminars for the KOMAC user program were provided. As results, lots of accelerator relate person and even publics could join or get acquainted with the KOMAC program. The research potential area for the KOMAC of near future was suggested and provided through the analysis of collected data and informations. (author). 38 figs., 19 tabs.

  17. Dynamics of a Successful Planned Giving Program Utilizing Shared Leadership at Historically Black Colleges and Universities (HBCUs)

    Science.gov (United States)

    Baldwin, Robin Lynn Brunty

    2013-01-01

    The purpose of this study was to evaluate the dynamics of a successful planned giving program utilizing shared leadership at Historically Black Colleges and Universities (HBCUs). This information will assist the leadership in determining if and how a successful planned giving program can be established for HBCUs. It is possible for planned gifts…

  18. Variables Influencing the Return on Investment in Management Training Programs: A Utility Analysis of 10 Swiss Cases

    Science.gov (United States)

    Chochard, Yves; Davoine, Eric

    2011-01-01

    In this article, we present the utility analysis approach as an alternative and promising approach to measure the return on investment in managerial training programs. This approach, linking economic value with competencies developed by trainees, enables researchers and decision-makers to compare the return on investment from different programs in…

  19. Background report for the formerly utilized Manhattan Engineer District/Atomic Energy Commission sites program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    The Department of Energy is conducting a program to determine radiological conditions at sites formerly used by the Army Corps of Engineers' Manhattan Engineer District and the Atomic Energy Commission in the early years of nuclear energy development. Also included in the program are sites used in the Los Alamos plutonium development program and the Trinity atomic bomb test site. Materials, equipment, buildings, and land became contaminated, primarily with naturally occurring radioactive nuclides. They were later decontaminated in accordance with the standards and survey methods in use at that time. Since then, however, radiological criteria, and proposed guidelines for release of such sites for unrestricted use have become more stringent as research on the effects of low-level radiation has progressed. In addition, records documenting some of these decontamination efforts cannot be found, and the final radiological conditions of the sites could not be adequately determined from the records. As a result, the Formerly Utilized Sites Program was initiated in 1974 to identify these formerly used sites and to reevaluate their radiological status. This report covers efforts through June 1980 to determine the radiological status of sites for which the existing conditions could not be clearly defined. Principal contractor facilities and associated properties have already been identified and activities are continuing to identify additional sites. Any new sites located will probably be subcontractor facilities and areas used for disposal of contractor waste or equipment; however, only limited information regarding this equipment and material has been collected to date. As additional information becomes available, supplemental reports will be published.

  20. Th-utilization in PWRs: status of work in the cooperative Brazilian/German program

    International Nuclear Information System (INIS)

    The major results of the program 'Th-Utilization in PWR's' are presented and discussed. The investigations show that the standard KWU-PWR can accomodate (Th,U)O2 and (Th,Pu)O2 fuels without changes in the fuel element design, in 3 and 4-batch operation scheme, without penalties in the reactor performance. An advanced fuel fabrication scheme using direct pelletizing methods out of ex-gel microspheres has been developed on laboratory scale. The (Th,U)O2 test fuel produced satisfies PWR-specification and is currently undergoing irradiation testing. Thermal and mechanical design of fuel pins with thorium based fuel is validated by the current instrumented single rod irradiation test. Cold laboratory investigations indicate that the (Th,UO2 PWR-fuel can be reprocessed using presently known technology, including the chopleach technique and modified THOREX extraction process. (Author)

  1. Development of utility program in ANSYS for evaluation of modal damping ratio

    International Nuclear Information System (INIS)

    In this report, an effective utility program to calculate the modal damping ratio required for dynamic analysis based on the method of mode-superposition is developed to enhance the dynamic analysis capability of the commercial code ANSYS. Though ANSYS is adopted as the major code for the structure analysis of the Korea Next Generation Reactor project, the needs to calculate the modal damping ratio directly in the ANSYS may raise the introduction of surplus codes of conservative numbers on the application of damping ratio. An effective method using intermediate data with inherent modules in ANSYS is developed to calculate the modal damping ration without intervention of other codes. (author). 5 refs., 2 tabs., 3 figs

  2. Antimicrobial Polymer

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, William F. (Utica, OH); Wright, Stacy C. (Flint, MI); Taylor, Andrew C. (Ann Arbor, MI)

    2004-09-28

    A polymeric composition having antimicrobial properties and a process for rendering the surface of a substrate antimicrobial are disclosed. The polymeric composition comprises a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, (ii) an antimicrobial agent selected from metals, metal alloys, metal salts, metal complexes and mixtures thereof, and (iii) a crosslinking agent containing functional groups capable of reacting with the amino groups. In one example embodiment, the polymer is a polyamide formed from a maleic anhydride or maleic acid ester monomer and alkylamines thereby producing a polyamide having amino substituted alkyl chains on one side of the polyamide backbone; the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl; and the metallic antimicrobial agent is selected from chelated silver ions, silver metal, chelated copper ions, copper metal, chelated zinc ions, zinc metal and mixtures thereof.

  3. The neutron utilization and promotion program of TRR-II research reactor project in Taiwan

    International Nuclear Information System (INIS)

    The objective of the Taiwan research reactor system improvement and utilization promotion project is to reconstruct the old Taiwan research reactor (TRR), which was operated by the Institute of Nuclear Energy Research (INER) between 1973 and 1988, into a multi-purpose medium flux research reactor (TRR-II). The project started in 1998, and the new reactor is scheduled to have its first critical in June of 2006. The estimated maximum unperturbed thermal neutron flux (E14 n/cm2sec, and it is about one order of magnitude higher than other operating research reactors in Taiwan. The new reactor will equip with secondary neutron sources to provide neutrons with different energies, which will be an essential tool for advanced material researches in Taiwan. One of the major tasks of TRR-II project is to promote domestic utilization of neutrons generated at TRR-II. The traditional uses of neutrons in fuel/material research, trace element analysis, and isotope production has been carried out at INER for many years. On the other hand, it is obvious that promotions of neutron spectrometric technique will be a major challenge for the project team. The limited neutron flux from operating research reactors had discouraged domestic users in developing neutron spectrometric technique for many years, and only few researchers in Taiwan are experienced in using spectrometers. It is important for the project team to encourage domestic researchers to use neutron spectrometers provided by TRR-II as a tool for their future researches in various fields. This paper describes the current status of TRR-II neutron utilization and promotion program. The current status and future plans for important issues such as staff recruiting, personnel training, international collaboration, and promotion strategy will be described. (orig.)

  4. U.S. Department of Energy Program of International Technical Cooperation for Research Reactor Utilization

    Energy Technology Data Exchange (ETDEWEB)

    Chong, D.; Manning, M.; Ellis, R.; Apt, K.; Flaim, S.; Sylvester, K.

    2004-10-03

    The U.S. Department of Energy, National Nuclear Security Administration (DOE/NNSA) has initiated collaborations with the national nuclear authorities of Egypt, Peru, and Romania for the purpose of advancing the commercial potential and utilization of their respective research reactors. Under its Office of International Safeguards ''Sister Laboratory'' program, DOE/NNSA has undertaken numerous technical collaborations over the past decade intended to promote peaceful applications of nuclear technology. Among these has been technical assistance in research reactor applications, such as neutron activation analysis, nuclear analysis, reactor physics, and medical radioisotope production. The current collaborations are intended to provide the subject countries with a methodology for greater commercialization of research reactor products and services. Our primary goal is the transfer of knowledge, both in administrative and technical issues, needed for the establishment of an effective business plan and utilization strategy for the continued operation of the countries' research reactors. Technical consultation, cooperation, and the information transfer provided are related to: identification, evaluation, and assessment of current research reactor capabilities for products and services; identification of opportunities for technical upgrades for new or expanded products and services; advice and consultation on research reactor upgrades and technical modifications; characterization of markets for reactor products and services; identification of competition and estimation of potential for market penetration; integration of technical constraints; estimation of cash flow streams; and case studies.

  5. A.G.A. program gives utilities a leg up on benchmarking

    International Nuclear Information System (INIS)

    In this era of downsizing, distribution companies are banding together under the aegis of the American Gas Association to improve their performance, ultimately saving money and jobs. The Best Practice Benchmarking program began in 1990 when New Orleans Public Service coordinated an effort by several utilities wanting to compare practices and data. It is not benchmarking in the traditional sense. Best Practices stresses functional rather than competitive or numerical benchmarking by focusing on what utilities have done to improve their operations. In a report on Best Practices, John Bayko, Director of System Operations for Consumers Gas in Toronto, noted these success stories: Building odorant storage and transport facilities were found to save one company $17,500 annually because it could buy odorant in bulk as opposed to 55-gallon drums. Upgrading its cathodic protection system helped a company realize a 40 percent reduction in corrosion leaks over a two-year period, saving $200,000 a year. Another company began studying partnering with contractors which would eliminate the need of a pipeline inspector in each crew. Those potential savings are over $2 million. This paper describes three other Best Practices related to worker safety, system mapping, and activity-based accounting. A.G.A.'s role is briefly discussed

  6. U.S. Department of Energy Program of International Technical Cooperation for Research Reactor Utilization

    International Nuclear Information System (INIS)

    The U.S. Department of Energy, National Nuclear Security Administration (DOE/NNSA) has initiated collaborations with the national nuclear authorities of Egypt, Peru, and Romania for the purpose of advancing the commercial potential and utilization of their respective research reactors. Under its Office of International Safeguards ''Sister Laboratory'' program, DOE/NNSA has undertaken numerous technical collaborations over the past decade intended to promote peaceful applications of nuclear technology. Among these has been technical assistance in research reactor applications, such as neutron activation analysis, nuclear analysis, reactor physics, and medical radioisotope production. The current collaborations are intended to provide the subject countries with a methodology for greater commercialization of research reactor products and services. Our primary goal is the transfer of knowledge, both in administrative and technical issues, needed for the establishment of an effective business plan and utilization strategy for the continued operation of the countries' research reactors. Technical consultation, cooperation, and the information transfer provided are related to: identification, evaluation, and assessment of current research reactor capabilities for products and services; identification of opportunities for technical upgrades for new or expanded products and services; advice and consultation on research reactor upgrades and technical modifications; characterization of markets for reactor products and services; identification of competition and estimation of potential for market penetration; integration of technical constraints; estimation of cash flow streams; and case studies

  7. Dynamic Power Management for Portable Hybrid Power-Supply Systems Utilizing Approximate Dynamic Programming

    Directory of Open Access Journals (Sweden)

    Jooyoung Park

    2015-05-01

    Full Text Available Recently, the optimization of power flows in portable hybrid power-supply systems (HPSSs has become an important issue with the advent of a variety of mobile systems and hybrid energy technologies. In this paper, a control strategy is considered for dynamically managing power flows in portable HPSSs employing batteries and supercapacitors. Our dynamic power management strategy utilizes the concept of approximate dynamic programming (ADP. ADP methods are important tools in the fields of stochastic control and machine learning, and the utilization of these tools for practical engineering problems is now an active and promising research field. We propose an ADP-based procedure based on optimization under constraints including the iterated Bellman inequalities, which can be solved by convex optimization carried out offline, to find the optimal power management rules for portable HPSSs. The effectiveness of the proposed procedure is tested through dynamic simulations for smartphone workload scenarios, and simulation results show that the proposed strategy can successfully cope with uncertain workload demands.

  8. Antimicrobial Stewardship: The Need to Cover All Bases

    OpenAIRE

    N Deborah Friedman

    2013-01-01

    Increasing antimicrobial resistance has necessitated an approach to guide the use of antibiotics. The necessity to guide antimicrobial use via stewardship has never been more urgent. The decline in anti-infective innovation and the failure of currently available antimicrobials to treat some serious infections forces clinicians to change those behaviors that drive antimicrobial resistance. The majority of antimicrobial stewardship (AMS) programs function in acute-care hospitals, however, hospi...

  9. Evaluating needle exchange: a description of client characteristics, health status, program utilization, and HIV risk behavior.

    Science.gov (United States)

    Guydish, J; Bucardo, J; Clark, G; Bernheim, S

    1998-04-01

    This study was designed to describe demographic and drug use characteristics, health status, and HIV-related risk behavior among clients attending the San Francisco needle exchange program (NEP), and to assess the relationship between NEP utilization and risk behavior. Randomly selected clients were interviewed when they visited the NEP. Participants were of diverse ethnicity, had a mean age of 38.2, and 72% were male. Many reported being homeless (25%), unemployed (34%), uninsured (52%), and having an episode of infectious disease in the past 2 years (36%). Clients who received a higher proportion of their needles from the exchange were less likely to report sharing of needles or rinse water. Clients who attended the exchange more frequently were more likely to clean their skin prior to injecting and less likely to use the same needle repeatedly. Frequency of visiting the NEP was not associated with the likelihood of sharing needles or rinse water. Efforts to evaluate needle exchange in the United States will benefit from descriptive reports from other NEP programs, and the use of nonexchange comparison groups.

  10. The Urban Ecology Institute's field studies program: utilizing urban areas for experiential learning and ecological research

    Science.gov (United States)

    Starry, O.

    2005-05-01

    The Urban Ecology Institute (UEI) promotes the stewardship of healthy urban ecosystems by improving science and civic education for middle and high school youth and by working with urban communities to protect and transform natural resources. Established in 1999, UEI's field studies program engages over 1000 youth in the greater Boston area. A substantial component of this program involves water quality monitoring. We have recently adapted protocols from published leaf breakdown studies for incorporation into the UEI water quality curriculum. A 2004 pilot study of these leaf breakdown activities, conducted at four sites, compared rates of red maple breakdown to those of Norway maple, a potentially invasive urban street tree. Preliminary data from this successful pilot study suggest that leaf litter inputs from the two different tree species have varying effects on stream ecosystem function. We present this study as an example of how urban areas can be utilized for both ecological research and inclusive experiential learning through which science and mathematic knowledge can be effectively communicated.

  11. The handwriting on the wall: program transformations utilizing effective change management strategies.

    Science.gov (United States)

    Amos, Anita; Johns, Colleen; Hines, Nordia; Skov, Tracey; Kloosterman, Linda

    2012-01-01

    Historically, there have been indications that we need to change the way we work and think about our health care processes. Yet, with the urgency to keep abreast of the changing needs of our patients, have we seen these signs? Moreover, how do we respond to the inevitable change processes that must occur? In 2010, St. Michael's entered into a five-year partnership with Baxter Canada. The overall goal is to improve the quality of care and life for people living with chronic kidney disease. This initiative was undertaken in response to concerns identified internally related to existing health care delivery processes within the renal program. As in any work environment, the depth and breadth of inevitable changes evoke a variety of responses that are based on the individual's attitudes regarding change. As we embarked on this journey, the nursing leadership team and staff within the program were encouraged to review their usual responses toward change utilizing the book, Who Moved My Cheese? (Johnson, 1998). It is imperative to identify the attitudes of those people involved in change processes. This awareness facilitates the use of specific strategies to enhance the effectiveness of their engagement in the process and the outcome of the initiative. Reading the writing on the wall prepares people to participate in and embrace changes that promise to benefit those for whom we provide professional care.

  12. Conceptual design report: below-grade bulk waste disposal facility. Formerly Utilized Sites Remedial Action Program

    International Nuclear Information System (INIS)

    This report presents two conceptual designs for below-grade land disposal facilities in the Northeastern United States for wastes managed under the Formerly Utilized Sites Remedial Action Program (FUSRAP). The wastes are low specific activity radioactive wastes generated by programs of the Manhattan Engineer District/Atomic Energy Commission (MED/AEC). One design presented is for a hypothetical disposal facility for the state of New York and one for the state of New Jersey. Each design is based on the estimated volume of FUSRAP waste in each state. Since no specific sites have been identified for the disposal facilities, the geologic, hydrologic, topographic, and meteorologic conditions chosen for the conceptual design are only representative of conditions in New York and New Jersey. The principal difference in the two sites is the assumed soil permeability which requires an engineered clay liner surrounding the waste for the New York facility, but not for the New Jersey facility. The conceptual designs are intended to be conservative and were developed to be compatible with proposed 10 CFR 61 and proposed 40 CFR 192. The designs are developed in sufficient detail to verify the feasibility of the design concepts and to provide a basis for developing capital cost estimates for below-grade land disposal facilities

  13. Utility Advanced Turbine Systems Program (ATS) Technical Readiness Testing and Pre-Commercial Demonstration

    Energy Technology Data Exchange (ETDEWEB)

    Siemens Westinghouse

    2001-09-30

    The objective of the ATS program is to develop ultra-high efficiency, environmentally superior and cost competitive gas turbine systems for base load application in utility, independent power producer and industrial markets. Specific performance targets have been set using natural gas as the primary fuel: (1) System efficiency that will exceed 60% (lower heating value basis) on natural gas for large scale utility turbine systems; for industrial applications, systems that will result in a 15% improvement in heat rate compared to currently available gas turbine systems. (2) An environmentally superior system that will not require the use of post combustion emissions controls under full load operating conditions. (3) Busbar energy costs that are 10% less than current state-of-the-art turbine systems, while meeting the same environmental requirements. (4) Fuel-flexible designs that will operate on natural gas but are capable of being adapted to operate on coal-derived or biomass fuels. (5) Reliability-Availability-Maintainability (RAM) that is equivalent to the current turbine systems. (6) Water consumption minimized to levels consistent with cost and efficiency goals. (7) Commercial systems that will enter the market in the year 2000. In Phase I of the ATS program, Siemens Westinghouse found that efficiency significantly increases when the traditional combined-cycle power plant is reconfigured with closed-loop steam cooling of the hot gas path. Phase II activities involved the development of a 318MW natural gas fired turbine conceptual design with the flexibility to burn coal-derived and biomass fuels. Phases I and II of the ATS program have been completed. Phase III, the current phase, completes the research and development activities and develops hardware specifications from the Phase II conceptual design. This report summarizes Phase III Extension activities for a three month period. Additional details may be found in monthly technical progress reports covering the

  14. Space biology initiative program definition review. Trade study 1: Automation costs versus crew utilization

    Science.gov (United States)

    Jackson, L. Neal; Crenshaw, John, Sr.; Hambright, R. N.; Nedungadi, A.; Mcfayden, G. M.; Tsuchida, M. S.

    1989-01-01

    A significant emphasis upon automation within the Space Biology Initiative hardware appears justified in order to conserve crew labor and crew training effort. Two generic forms of automation were identified: automation of data and information handling and decision making, and the automation of material handling, transfer, and processing. The use of automatic data acquisition, expert systems, robots, and machine vision will increase the volume of experiments and quality of results. The automation described may also influence efforts to miniaturize and modularize the large array of SBI hardware identified to date. The cost and benefit model developed appears to be a useful guideline for SBI equipment specifiers and designers. Additional refinements would enhance the validity of the model. Two NASA automation pilot programs, 'The Principal Investigator in a Box' and 'Rack Mounted Robots' were investigated and found to be quite appropriate for adaptation to the SBI program. There are other in-house NASA efforts that provide technology that may be appropriate for the SBI program. Important data is believed to exist in advanced medical labs throughout the U.S., Japan, and Europe. The information and data processing in medical analysis equipment is highly automated and future trends reveal continued progress in this area. However, automation of material handling and processing has progressed in a limited manner because the medical labs are not affected by the power and space constraints that Space Station medical equipment is faced with. Therefore, NASA's major emphasis in automation will require a lead effort in the automation of material handling to achieve optimal crew utilization.

  15. Evaluation of Orange and Rockland Utilities, Inc.`s competitive bidding program for demand-side resources. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Peters, J.S.; Stucky, L.; Seratt, P.; Darden-Butler, D. [Barakat and Chamberlin, Inc., Portland, OR (United States)

    1993-02-01

    The process evaluation reports on the implementation of Orange and Rockland Utilities demand-side bidding program in New York State during 1991 and 1992. The program is implemented by two energy service companies in Orange and rockland`s New York State service territory. The process evaluation methodology included interviews with utility staff (3), energy service company staff (2), and participating (6) and nonparticipating (7) utility customers. The two energy service companies had enrolled 14 customers in the program by summer 1992. One company had achieved 90% of their 2.75 MW bid and the other had achieved less than 90% of their 6.9 MW bid. Critical factors in success were determination of a reasonable bid amount for the market and marketing to the appropriate customers. Customers most interested in the program included those with limited access to capital and medium-sized firms with poor cash flows, particularly schools and hospitals. The findings also show that due to the incentive structure and associated need for substantial customer contributions, lighting measures dominate all installations. Customers, however, were interested in the potential savings and six of the nonparticipants chose to either install measures on their own or enroll in the utility`s rebate program.

  16. Antimicrobial technology in orthopedic and spinal implants

    Science.gov (United States)

    Eltorai, Adam EM; Haglin, Jack; Perera, Sudheesha; Brea, Bielinsky A; Ruttiman, Roy; Garcia, Dioscaris R; Born, Christopher T; Daniels, Alan H

    2016-01-01

    Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines orthopedic implant antimicrobial technology, its current applications and supporting evidence, and clinically promising future directions. PMID:27335811

  17. Effects of Breakpoint Changes on Carbapenem Susceptibility Rates ofEnterobacteriaceae: Results from the SENTRY Antimicrobial Surveillance Program, United States, 2008 to 2012

    Directory of Open Access Journals (Sweden)

    Robert P Rennie

    2014-01-01

    Full Text Available In the absence of clinical resistance, breakpoints for many antimicrobial agents are often set high. Clinical failures following use of the agents over time requires re-evaluation of breakpoints. This is based on patient response, pharmacokinetic/pharmacodynamic information and in vitro minimal inhibitory concentration data. Data from the SENTRY Antimicrobial Surveillance Program has shown that Clinical and Laboratory Standards Institute breakpoint changes for carbapenems that occurred between 2008 and 2012 in North America have resulted in decreased levels of susceptibility for some species. In particular, reduced susceptibility to imipenem was observed for Proteus mirabilis (35% and Morganella morganii (80%. Minor decreases in susceptibility were also noted for Enterobacter species with ertapenem (5% and imipenem (4.3%, and Serratia species with imipenem (6.4%. No significant decreases in susceptibility were observed for meropenem following the breakpoint changes. There were no earlier breakpoints established for doripenem. Very few of these Enterobacteriaceae produce carbapenamase enzymes; therefore, the clinical significance of these changes has not yet been clearly determined. In conclusion, ongoing surveillance studies with in vitro minimum inhibitory concentration data are essential in predicting the need for breakpoint changes and in identifying the impact of such changes on the percent susceptibility of different species.

  18. How physicians perceive and utilize information from a teratogen information service: The Motherisk Program

    Directory of Open Access Journals (Sweden)

    Park Andrew

    2004-04-01

    Full Text Available Abstract Background Teratogen information services have been developed around the world to disseminate information regarding the safety of maternal exposures during pregnancy. The Motherisk Program in Toronto, Canada, fields thousands of these inquiries per year. Our primary objective was to evaluate the perception and utilization of information received from us by physicians. Our secondary objective was to examine their information seeking behavior, in particular regarding teratogen information. Methods A one page survey was sent to physicians who had called Motherisk for information concerning pregnancy exposures in the previous 30 days for three months. Among the questions that were asked were demographics, which included gender, years in practice, specialty, information resources, and how they utilized the information received from Motherisk. Results We received 118/200 completed questionnaires (59% response rate. The mean age of the respondents was: 42 ± 9 years, mean years of practice was: 14 ± 8 years, males: 46(38% and females 72(62% and 95(80% were family physicians. 56(48% researched their question prior to calling Motherisk, 106(91% and passed on the information received to their patient verbatim. The top four resources for information were: 1 The CPS (PDR, 2 textbooks, 3 journals and 4 colleagues. Only 8% used the Medline for gathering information. Conclusions Physicians feel that a teratogen information service is an important component in the management of women exposed to drugs, chemicals, radiation and infections diseases etc. during pregnancy. Despite the advent of the electronic age, a minority of the physicians in our survey elected to use electronic means to seek information.

  19. User's guide to SERICPAC: A computer program for calculating electric-utility avoided costs rates

    Energy Technology Data Exchange (ETDEWEB)

    Wirtshafter, R.; Abrash, M.; Koved, M.; Feldman, S.

    1982-05-01

    SERICPAC is a computer program developed to calculate average avoided cost rates for decentralized power producers and cogenerators that sell electricity to electric utilities. SERICPAC works in tandem with SERICOST, a program to calculate avoided costs, and determines the appropriate rates for buying and selling of electricity from electric utilities to qualifying facilities (QF) as stipulated under Section 210 of PURA. SERICPAC contains simulation models for eight technologies including wind, hydro, biogas, and cogeneration. The simulations are converted in a diversified utility production which can be either gross production or net production, which accounts for an internal electricity usage by the QF. The program allows for adjustments to the production to be made for scheduled and forced outages. The final output of the model is a technology-specific average annual rate. The report contains a description of the technologies and the simulations as well as complete user's guide to SERICPAC.

  20. Tendências na utilização de antimicrobianos em um hospital universitário, 1990-1996 Trends in antimicrobial utilization in a university hospital, 1990-1996

    Directory of Open Access Journals (Sweden)

    Mauro Silveira de Castro

    2002-10-01

    specifically related to antimicrobial utilization. In developing countries, few resources are intended for monitoring on rational drug use. Moreover, there are limited data on the use of antimicrobial agents in hospitals. A study was carried out to describe patterns of use of antimicrobial agents over a 7-year period (1990 to 1996. METHODS: The study was conducted in a 690-bed tertiary care university hospital in Porto Alegre, Brazil. Hospital records were reviewed to identify inpatient antibiotics use. Results were expressed in defined daily dose per 100-beds/day. Cluster analysis was performed to determine the trends in use of individual agents. RESULTS: Antimicrobials use increased year after year, from 83.8 DDD per 100 beds-day in 1990 to 124.58 DDD per 100 beds-day in 1996. Penicillins were the drug group mostly used (39.6%, followed by cephalosporins (15.0%, aminoglycosides (14.4%, sulfonamides (12.8%, glycopeptides (3.6%, and lincosamides (3.1%. These groups were responsible for around 90% of all agents used. The use of antimicrobial agents was divided into thirteen groups based on cluster analysis. CONCLUSIONS: Antimicrobial use increased dramatically in the study period, and this increase was significantly higher when compared to other studies. When newer alternative agents became available in the hospital, the use of already existing drugs decreased and in some cases remained relatively stable. After implementing specific interventions, such as an effort for the correct use of cefoxitin, the expected changes in use were observed.

  1. LFTR: in search of the ideal pathway to thorium utilization-development program and current status

    International Nuclear Information System (INIS)

    Thorium has gained substantial attention as a potential energy source that could rival and eventually replace fossil fuels as humanity's primary energy source. This could not have come at a more opportune time as concerns about global climate change from CO2 emissions and the approaching spectre of finite fossil fuel resources create serious challenges for the continuation of our advanced industrial societies, which are reliant on readily available and affordable energy. Thorium also potentially represents the catalyst with which the nuclear industry could reinvent itself and finally gain widespread public acceptance. There are many opinions on how to utilize thorium as a fuel, but the question of what constitutes an 'ideal' pathway has mostly been under-emphasized. Many specific characteristics of the thorium fuel cycle can differ significantly depending on the conditions and methodologies of utilization; characteristics such as safety, efficiency, waste profile and volume, and fissile protection can vary greatly according to reactor design and utilization philosophy. With thorium, we have been given an opportunity to start over, a blank slate. Therefore, in imagining the 'Thorium Economy' to come, it behoves the scientific and engineering communities to consider the most 'elegant' solution physically possible-what constitutes the 'ideal' and is it possible to reconcile it with what is both economically and technically practical? The characteristics desired of an 'ideal' nuclear reactor, in the areas of safety, efficiency, economy, and sustainability, and the 5 key design choices that could enable such a reactor will be discussed. This will be followed by an overview of the Liquid Fluoride Thorium Reactor, a 2-fluid Molten Salt Reactor currently under development by Flibe Energy in the United States. LFTR is a direct descendant of the MSRE, which was developed at Oak Ridge National Laboratory (ORNL) in the

  2. Project selection problem under uncertainty: An application of utility theory and chance constrained programming to a real case

    Directory of Open Access Journals (Sweden)

    Reza Hosnavi Atashgah

    2013-06-01

    Full Text Available Selecting from a pool of interdependent projects under certainty, when faced with resource constraints, has been studied well in the literature of project selection problem. After briefly reviewing and discussing popular modeling approaches for dealing with uncertainty, this paper proposes an approach based on chance constrained programming and utility theory for a certain range of problems and under some practical assumptions. Expected Utility Programming, as the proposed modeling approach, will be compared with other well-known methods and its meaningfulness and usefulness will be illustrated via two numerical examples and one real case.

  3. Synthesis and antimicrobial activity of squalamine analogue.

    Science.gov (United States)

    Kim, H S; Choi, B S; Kwon, K C; Lee, S O; Kwak, H J; Lee, C H

    2000-08-01

    Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine. PMID:11003150

  4. Utility of the Living (Well Through) Intergenerational Fitness and Exercise Program as a County-Delivered Extension Program

    Science.gov (United States)

    Sowle, Ashleigh J.; Francis, Sarah L.; Margrett, Jennifer A.; Franke, Warren D.

    2016-01-01

    Rural-residing older adults are not participating in regular physical activity. Extension is in an excellent position to fill this programming void through transdisciplinary programming such as the Living (well through) Intergenerational Fitness and Exercise (LIFE) program. Qualitative evaluation was conducted to assess the LIFE program's utility…

  5. Electrical utility generating system reliability analysis code, SYSREL. Social cost studies program

    Energy Technology Data Exchange (ETDEWEB)

    Hub, K.; Conley, L.; Buehring, W.; Rowland, B.; Stephenson, M.

    1975-09-01

    The system reliability code, SYSREL, is a system planning tool that can be used to assess the reliability and economic performance of alternative expansion patterns of electric utility generation systems. Given input information such as capacity, forced-outage rate, number of weeks of annual scheduled maintenance, and economic data for individual units along with the expected load characteristics, the code produces estimates of the mean time between system failures, required reserve capacity to meet a specified system-failure-frequency criterion, expected energy generation from each unit, and system energy cost. The categories of calculations performed by the code are maintenance scheduling, reliability, capacity requirement, energy production allocation, and energy cost. The code is designed to examine alternative generating units and system expansion patterns based on the constraints and general economic conditions imposed by the investigator. The computer running time to execute a study is short and many system alternatives can be examined at a relatively low cost. The report contains a technical description of the code, list of input data requirements, program listing, sample execution, and parameter studies. (auth)

  6. Determination of ecologically vital groundwaters at selected sites in the Formerly Utilized Sites Remedial Action Program

    Energy Technology Data Exchange (ETDEWEB)

    Vinikour, W.S.; Yin, S.C.L.

    1989-08-01

    The US Department of Energy is classifying groundwaters at sites in its Formerly Utilized Sites Remedial Action Program (FUSRAP). Of particular concern is the potential presence of groundwaters that are highly vulnerable to contamination and that are either (1) irreplaceable sources of drinking water or (2) ecologically vital. Conditions at nine FUSRAP sites were evaluated to determine if ecologically vital groundwaters are present. The sites evaluated were Wayne Interim Storage Site, Maywood Interim Storage Site, and Middlesex Sampling Plant in New Jersey; Ashland 2 Site, Seaway Industrial Park, Colonie Interim storage Site, and Niagara Falls Storage Site in New York; and the St. Louis Airport Site and Hazelwood Interim Storage Site in Missouri. The analyses indicated that groundwaters are vulnerable to contamination at all but two of the sites -- the Ashland 2 and Seaway Industrial Park sites in New York. Groundwater discharge points were identified within a 2-mile radius (i.e., the classification review area) of all of the sites. No ecologically vital groundwater areas exist in the vicinities of any of the nine FUSRAP sites evaluated. 35 refs., 17 figs.

  7. E-FUSRAP: AUTOMATING THE CASE FILE FOR THE FORMERLY UTILIZED SITES REMEDIAL ACTION PROGRAM

    Energy Technology Data Exchange (ETDEWEB)

    Mackenzie, D.; Marshall, K.

    2003-02-27

    The Department of Energy's (DOE) Office of Site Closure, EM-30, houses the document library pertaining to sites that are related to the Formerly Utilized Sites Remedial Action Program (FUSRAP) and regularly addresses ongoing information demands, primarily from Freedom of Information Act (FOIA) requests, interested members of the public, the DOE, and other Federal Agencies. To address these demands more efficiently, DOE has begun to implement a new multi-phase, information management process known as e-FUSRAP. The first phase of e-FUSRAP, the development of the Considered Sites Database, summarizes and allows public access to complex information on over 600 sites considered as candidates for FUSRAP. The second phase of e-FUSRAP, the development of the Document Indexing Database, will create an internal index of more than 10,000 documents in the FUSRAP library's case file, allowing more effective management and retrieval of case file documents. Together, the phases of e-FUSRAP will allow EM-30 to become an innovative leader in enhancing public information sources.

  8. Overview of the U.S. Department of Energy Formerly Utilized Sites Remedial Action Program - 12189

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Christopher [U.S. Department of Energy Office of Legacy Management, Washington, DC; Kothari, Vijendra [U.S. Department of Energy Office of Legacy Management, Morgantown, West Virginia; Starr, Ken [U.S. Department of Energy Office of Legacy Management, Westminster, Colorado; Gillespie, Joey [S.M. Stoller Corporation, Contractor for the U.S. Department of Energy Office of Legacy Management, Grand Junction, Colorado; Widdop, Michael [S.M. Stoller Corporation, Contractor for the U.S. Department of Energy Office of Legacy Management, Grand Junction, Colorado; none,

    2012-02-26

    The U.S. Department of Energy (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP) was established in 1974 to address residual radiological contamination at sites where work was performed for the Manhattan Engineer District and U.S. Atomic Energy Commission. Initially, FUSRAP activities began with a records search for sites that had the potential to contain residual radiological contamination; 46 sites were identified that were eligible for and required remediation. Remedial action began in 1979. In 1997, Congress assigned responsibility for the remediation of FUSRAP sites to the U.S. Army Corps of Engineers (USACE). DOE retains responsibility for determining if sites are eligible for FUSRAP remediation and for providing long-term surveillance and maintenance (LTS&M) of remediated FUSRAP sites. DOE LTS&M activities are designed to ensure that FUSRAP sites remain protective of human health and the environment and to preserve knowledge regarding FUSRAP sites. Additional elements include eligibility determinations, transition of remediated sites from USACE to DOE, LTS&M operations such as inspections and institutional controls management, stakeholder support, preservation of records, and real property and reuse. DOE maintains close coordination with USACE and regulators to ensure there is no loss of protectiveness when sites transition to DOE for LTS&M.

  9. Site study plan for utilities and solid waste, Deaf Smith County Site, Texas: Environmental Field Program: Preliminary draft

    Energy Technology Data Exchange (ETDEWEB)

    1987-06-01

    This site plan describes utilities and solid waste studies to be conducted during the characterization of the Deaf Smith County, Texas, site for the US Department of Energy's Salt Repository Project. After utilities and solid waste information needs derived from Federal, State, and local statutes and regulations and the project specifications are briefly described, the site study plan describes the study design and rationale, the field data collection procedures and equipment, and data analysis methods and application of results, the data management strategy, the schedule of field activities, the management of the study, and the study's quality assurance program. The field data collection activities are organized into programs to characterize electrical power, natural gas, communication, water, wastewater sludge, nonradiological solid waste, nonradiological hazardous waste, and low-level radiological waste. These programs include details for the collection of project needs, identification of utilities and solid waste disposal contractor capabilities, and verification of the obtained data. Utilities and solid waste field activities will begin approximately at the time of site access. Utilities and solid waste characterization will be completed within the first year of activity. 29 refs., 6 figs., 2 tabs.

  10. Site study plan for utilities and solid waste, Deaf Smith County Site, Texas: Environmental Field Program: Preliminary draft

    International Nuclear Information System (INIS)

    This site plan describes utilities and solid waste studies to be conducted during the characterization of the Deaf Smith County, Texas, site for the US Department of Energy's Salt Repository Project. After utilities and solid waste information needs derived from Federal, State, and local statutes and regulations and the project specifications are briefly described, the site study plan describes the study design and rationale, the field data collection procedures and equipment, and data analysis methods and application of results, the data management strategy, the schedule of field activities, the management of the study, and the study's quality assurance program. The field data collection activities are organized into programs to characterize electrical power, natural gas, communication, water, wastewater sludge, nonradiological solid waste, nonradiological hazardous waste, and low-level radiological waste. These programs include details for the collection of project needs, identification of utilities and solid waste disposal contractor capabilities, and verification of the obtained data. Utilities and solid waste field activities will begin approximately at the time of site access. Utilities and solid waste characterization will be completed within the first year of activity. 29 refs., 6 figs., 2 tabs

  11. Central Wind Forecasting Programs in North America by Regional Transmission Organizations and Electric Utilities: Revised Edition

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, J.; Porter, K.

    2011-03-01

    The report and accompanying table addresses the implementation of central wind power forecasting by electric utilities and regional transmission organizations in North America. The first part of the table focuses on electric utilities and regional transmission organizations that have central wind power forecasting in place; the second part focuses on electric utilities and regional transmission organizations that plan to adopt central wind power forecasting in 2010. This is an update of the December 2009 report, NREL/SR-550-46763.

  12. State Clean Energy Policies Analysis. State, Utility, and Municipal Loan Programs

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, Eric [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2010-05-01

    This report relies on six in-depth interviews with loan program administrators to provide descriptions of existing programs. Findings from the interviews are combined with a review of relevant literature to elicit best practices and lessons learned from existing loan programs. Data collected from each of the loan programs profiled are used to quantify the impacts of these specific loan programs on the commonly cited, overarching state clean energy goals of energy security, economic development, and environmental protection.

  13. Transportable educational programs for scientific and technical professionals: More effective utilization of automated scientific and technical data base systems

    Science.gov (United States)

    Dominick, Wayne D.

    1987-01-01

    This grant final report executive summary documents a major, long-term program addressing innovative educational issues associated with the development, administration, evaluation, and widespread distribution of transportable educational programs for scientists and engineers to increase their knowledge of, and facilitate their utilization of automated scientific and technical information storage and retrieval systems. This educational program is of very broad scope, being targeted at Colleges of Engineering and Colleges of Physical sciences at a large number of colleges and universities throughout the United States. The educational program is designed to incorporate extensive hands-on, interactive usage of the NASA RECON system and is supported by a number of microcomputer-based software systems to facilitate the delivery and usage of the educational course materials developed as part of the program.

  14. Low-level airborne monitoring techniques utilized in a field measurement program at operating pressurized water reactors

    International Nuclear Information System (INIS)

    An in-plant measurement program, sponsored by the Nuclear Regulatory Commission's Office of Nuclear Regulatory Research is underway at commercial nuclear power stations. The objective of this program, the in-plant source term measurement program, is to provide the Nuclear Regulatory Commission with experimental data that can be used in the evaluation of plant desgns for liquid and gaseous effluent treatment systems. As a part of this program, measurements have been made of low-level airborne radioactivity concentrations and release rates. A discussion of these measurement methods, which have been either utilized or developed specifically in support of this measurement program, is given. The monitoring methods discussed include several types of radioiodine species samplers in addition to an atmospheric 14C and tritium sampler. Each method is individually evaluated with emphasis upon: system description, observed detection limits, sample preparation, analysis, problems encountered in field use, and appropriate usage in a nuclear power plant ventilation system

  15. Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming : Experiences from an Intervention Study to Control Livestock-Associated MRSA

    OpenAIRE

    Dorado-García, Alejandro; Graveland, Haitske; Marian E H Bos; Verstappen, Koen M; Van Cleef, Brigitte A. G. L.; Kluytmans, Jan A. J. W.; Wagenaar, Jaap A.; Heederik, Dick J.J.

    2015-01-01

    With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU) in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA). Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cle...

  16. Technical procedures for utilities and solid waste: Environmental Field Program, Deaf Smith County site, Texas: Final draft

    Energy Technology Data Exchange (ETDEWEB)

    1987-08-01

    The evaluation of environmental issues and concerns and the addressing of statutory requirements are fundamental parts in the characterization of the site in Deaf Smith County, Texas for the US Department of Energy's Salt Repository Project (SRP). To ensure that the environmental field program comprehensively addresses the issues and requirements of the project, a site study plan (SSP) has been prepared for Utilities and Solid Waste considerations. This technical procedure (TP) has been developed to implement the field program described in the Utilities and Solid Waste Site Study Plan. The purpose and scope of the Utilities and Solid Waste Technical Procedure is to develop and implement a data collection procedure to fulfill the data base needs of the Utilities and Solid Waste SSP. The procedure describes a method of obtaining, assessing and verifying the capabilities of the regional service utilities and disposal contractors. This data base can be used to identify a preferred service source for the engineering contractor. The technical procedure was produced under the guidelines established in Technical Administrative Procedure No. 1.0, Preparation, Review and Approval of Technical Procedures.

  17. Antimicrobial resistance

    DEFF Research Database (Denmark)

    Llor, Carl; Bjerrum, Lars

    2014-01-01

    Antimicrobial resistance is a global public health challenge, which has accelerated by the overuse of antibiotics worldwide. Increased antimicrobial resistance is the cause of severe infections, complications, longer hospital stays and increased mortality. Overprescribing of antibiotics...... is associated with an increased risk of adverse effects, more frequent re-attendance and increased medicalization of self-limiting conditions. Antibiotic overprescribing is a particular problem in primary care, where viruses cause most infections. About 90% of all antibiotic prescriptions are issued by general...... practitioners, and respiratory tract infections are the leading reason for prescribing. Multifaceted interventions to reduce overuse of antibiotics have been found to be effective and better than single initiatives. Interventions should encompass the enforcement of the policy of prohibiting the over...

  18. Antimicrobial Peptides

    Directory of Open Access Journals (Sweden)

    Ali Adem Bahar

    2013-11-01

    Full Text Available The rapid increase in drug-resistant infections has presented a serious challenge to antimicrobial therapies. The failure of the most potent antibiotics to kill “superbugs” emphasizes the urgent need to develop other control agents. Here we review the history and new development of antimicrobial peptides (AMPs, a growing class of natural and synthetic peptides with a wide spectrum of targets including viruses, bacteria, fungi, and parasites. We summarize the major types of AMPs, their modes of action, and the common mechanisms of AMP resistance. In addition, we discuss the principles for designing effective AMPs and the potential of using AMPs to control biofilms (multicellular structures of bacteria embedded in extracellular matrixes and persister cells (dormant phenotypic variants of bacterial cells that are highly tolerant to antibiotics.

  19. Antimicrobial Agents

    Directory of Open Access Journals (Sweden)

    Sigrid Mayrhofer

    2011-01-01

    Full Text Available Strains of the genus Bifidobacterium are frequently used as probiotics, for which the absence of acquired antimicrobial resistance has become an important safety criterion. This clarifies the need for antibiotic susceptibility data for bifidobacteria. Based on a recently published standard for antimicrobial susceptibility testing of bifidobacteria with broth microdilution method, the range of susceptibility to selected antibiotics in 117 animal bifidobacterial strains was examined. Narrow unimodal MIC distributions either situated at the low-end (chloramphenicol, linezolid, and quinupristin/dalfopristin or high-end (kanamycin, neomycin concentration range could be detected. In contrast, the MIC distribution of trimethoprim was multimodal. Data derived from this study can be used as a basis for reviewing or verifying present microbiological breakpoints suggested by regulatory agencies to assess the safety of these micro-organisms intended for the use in probiotics.

  20. The impact of a conditional cash transfer program on the utilization of non-targeted services: Evidence from Afghanistan.

    Science.gov (United States)

    Witvorapong, Nopphol; Foshanji, Abo Ismael

    2016-03-01

    While existing research suggests that health-related conditional cash transfer (CCT) programs have positive impacts on the utilization of CCT-targeted health services, little is known as to whether they also influence the utilization of non-targeted health services-defined as general health services for which program participants are not financially motivated. Based on a sample of 6649 households in a CCT program that took place in May 2009-June 2011 in Afghanistan, we evaluate the impact of the receipt of CCTs on the utilization of non-targeted health services both by women, who were direct beneficiaries of the program, and by members of their households. We estimate the outcomes of interest through four probit models, accounting for potential endogeneity of the CCT receipt and dealing with lack of credible exclusion restrictions in different ways. In comparison with the control group, the receipt of CCTs is found to be associated with an increase in the probability of utilizing non-targeted services among household members across regression models. The results are mixed, with regard to the utilization by women, suggesting that there exist non-economic barriers to health care, unique to women, that are not captured by the data. The results confirm the importance of accounting for direct as well as indirect effects in policy evaluation and suggest that future studies investigate more deeply the role of community health workers in removing non-economic barriers for Afghan women and the possibility of introducing an incentive structure to motivate them to contribute more actively to population health in Afghanistan. PMID:26851407

  1. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... how antimicrobial resistance both emerges and proliferates among bacteria. Over time, the use of antimicrobial drugs will result in the development of resistant strains of bacteria, complicating clinician's efforts to select the appropriate antimicrobial ...

  2. Animation of Antimicrobial Resistance

    Science.gov (United States)

    ... Veterinary Home Animal & Veterinary Safety & Health Antimicrobial Resistance Animation of Antimicrobial Resistance Share Tweet Linkedin Pin it ... Veterinary Medicine is cited as the corporate author. Animation Animation of Antimicrobial Resistance (WMV - 19.2MB) 9: ...

  3. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... 08 Animation of Antimicrobial Resistance (text version) Arabic Translation - Animation of Antimicrobial Resistance (WMV - 19.2MB) Chinese Translation - Animation of Antimicrobial Resistance (WMV - 19.2MB) French ...

  4. Analysis on the utilization of antimicrobials and bacterial drug resistance in our hospital in 2010%我院2010年抗菌药物应用与细菌耐药性分析

    Institute of Scientific and Technical Information of China (English)

    王霞

    2012-01-01

    目的 总结首都医科大学附属北京佑安医院抗菌药物应用及细菌耐药情况.方法 采用回顾性调查方法,对2010年住院药房抗菌药物的消耗量、用药频度(DDDs)及病原菌耐药情况进行统计分析.结果 头孢菌素类、喹诺酮类和头霉素类抗菌药物的DDDs排在前3位,分别为33 508.2、32 630.5及27 135.3.临床分离的常见病原菌是大肠埃希菌、葡萄球菌、肺炎克雷伯菌、铜绿假单胞菌和屎肠球菌.除铜绿假单胞菌对亚胺培南、美罗培南耐药率达30%外.大肠埃希菌、肺炎克雷伯菌和阴沟肠杆菌对阿米卡星、亚胺培南和美罗培南耐药率最低,革兰阳性球菌对万古霉素和利奈唑胺耐药率最低.结论 应加强抗菌药物分级管理和细菌耐药监测工作,根据病原菌种类及细菌药敏试验结果选择抗菌药物.%Objective To investigate the utilization of antimicrobials and the situations of drug- resistance bacteria in Beijing You'an hospital and to provide reference for use of drugs in the clinic. Methods The consumption of antimicrobials, defined daily doses (DDDs) and drug-resistance bacteria for inpatients in the hospital 2010 were analyzed statistically. Results The top three categories of antimicrobials in the list of DDDs were cephalosporins (33 508.2), quinolones (32 630.5) and cephalomycin (27 135.3). The general bacteria were Escherichia coli, Klebsiella pneumoniae, Pseudomonsa aeruginosa. The resistance rates of Escherichia coli, Klebsiella pneumaniae, and Enterobacter cloacae were the lowest to amikacin, imipenem and meropenem. For gram -positive bacteria, the vancomycin -resistance and linezolid-resistance were minimum. Conclusions Great importance should be attached to classification management of antimicrobials and bacterial drug resistance monitoring. Rational use of antibacterials should base on the kinds of pathogenic bacteria and results of drug susceptibility.

  5. 77 FR 19288 - Medicare Program; Renewal of Deeming Authority of the Utilization Review Accreditation Commission...

    Science.gov (United States)

    2012-03-30

    ... of the Utilization Review Accreditation Commission for Medicare Advantage Health Maintenance... covered services through a Medicare Advantage (MA) organization that contracts with CMS. The regulations specifying the Medicare requirements that must be met for a Medicare Advantage Organization (MAO) to...

  6. 77 FR 31364 - Medicare Program; Approved Renewal of Deeming Authority of the Utilization Review Accreditation...

    Science.gov (United States)

    2012-05-25

    ... Authority of the Utilization Review Accreditation Commission for Medicare Advantage Health Maintenance...), HHS. ACTION: Final notice. SUMMARY: This notice announces our decision to renew the Medicare Advantage... receive covered services through a Medicare Advantage (MA) organization that contracts with CMS....

  7. Goal-Programming Model Based on the Utility Function of the Decision-maker

    Institute of Scientific and Technical Information of China (English)

    WANG Zhi-jiang

    2001-01-01

    Based on the analysis of the problems in traditional GP model, this paper provides the model with the utility function of the decision-maker and compares this model with the one presented in reference article [1].

  8. Evaluation of utility residential energy conservation programs: A Pacific Northwest example

    Energy Technology Data Exchange (ETDEWEB)

    Hirst, E.; Bronfman, B.; Goeltz, R.; Keating, K.; Lerman, D.; Timble, J.

    1984-03-01

    This paper describes a detailed quantitative evaluation of the Residential Weatherization Pilot Program, operated by the Bonneville Power Administration from 1980 through 1982. The program provided free energy audits to more than 6000 electrically-heated homes and gave zero-interest loans to weatherize almost 4000 of these audited homes. The total cost of the program was almost $8 million. Using actual electricity consumption records for program participants and nonparticipants, we calculated the energy-saving effect of the pilot program in several ways and always reached the same conclusion. Households that received an audit and weatherization loan reduced their annual electricity consumption by about 3500 kWh relative to what they would have done without the program; this 3500 kWh is the saving that can be directly attributed to the program. Using a simple net present worth approach, the authors computed program benefits and costs for participating households, the BPA power system, and the Pacific Northwest region as a whole. Under a wide range of assumptions concerning discount rate, years until the weatherization loan is repaid, program energy saving, and BPA's marginal cost of power, the program is economically attractive from all three perspectives.

  9. 国家动物源细菌耐药性监测工作的探讨和建议%Discussion and Suggestion on the National Antimicrobial Resistance Monitoring and Surveillance Program in Animals

    Institute of Scientific and Technical Information of China (English)

    顾欣; 金凌艳; 蔡金华; 刘雅妮; 王蓓

    2009-01-01

    The foreign profile of antimicrobial resistance monitoring and surveillance program in animal, and the purpose of resistance monitoring and surveillance program were described. A variety of factors to be considered for resistance monitoring and surveillance program were introduced and discussed, including the animal species, food products, Sampling strategies, specimens collecting, bacterial species, antimicrobials, standardized susceptibility testing, quality control, database design and recording, report and analysis of result. Suggestion was pointed out about antimicrobial resistance monitoring and surveillance program in the future.%介绍了国外动物源细菌耐药性监测工作的情况及目标,对我国的动物源细菌耐药性监测工作需考虑的许多因素进行了介绍和讨论,包括动物品种、食品、采样方法、样本的收集、细菌品种、抗菌药物、标准药敏试验法、质控、结果记录和数据库设计、报告和结果分析等,并对今后的动物源细菌耐药性监测工作提出了建议.

  10. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... More in Antimicrobial Resistance National Antimicrobial Resistance Monitoring System ... Note: If you need help accessing information in different file formats, see Instructions for Downloading ...

  11. An Integer Programming Approach and Implementation for an Electric Utility Capacity Planning Problem with Renewable Energy Sources

    OpenAIRE

    Hanif D. Sherali; Konstantin Staschus; Jorge M. Huacuz

    1987-01-01

    This paper presents an integer programming model and algorithm for an electric utility capacity expansion problem which considers the option of investing in nondispatchable or renewable energy sources. A branch-and-bound algorithm is proposed for this problem in which the continuous relaxation of the subproblem associated with each node in the enumeration tree is solved via an efficient two-phase procedure. This procedure solves a deterministic approximation of the problem in the first phase ...

  12. Study on utilization status of internet and needs assessment for developing nutrition education programs among elementary school children

    OpenAIRE

    Ahn, Yun; Kim, Kyung-Won

    2007-01-01

    This study was to investigate utilization status of internet, health/nutrition websites among children, and to assess the needs for developing nutrition websites and education programs for children. The survey questionnaire was administered to 5-6th grade students (n=434) at two elementary schools. About 32% used the internet every day while 19.5% used it whenever they needed, showing significant differences in internet usage by gender (p

  13. Data gathering in support of phase O program for waste heat utilization from nuclear enrichment facilities, Ohio

    International Nuclear Information System (INIS)

    The gathering of demographic, community development, and economic data for the region impacted by the Pikeville (Ohio) Nuclear Enrichment Facility is described. These data are to be used for establishing possible community uses, e.g., space heating, domestic water heating, and industrial uses, of waste heat from the facility. It was concluded that although the economic feasibility of such waste heat utilization remains to be proven, the community would cooperate in a feasibility demonstration program

  14. Fuel utilization potential in light water reactors with once-through fuel irradiation (AWBA Development Program)

    International Nuclear Information System (INIS)

    Current commercial light water reactor cores operate without recylce of fuel, on a once-through fuel cycle. To help conserve the limited nuclear fuel resources, there is interest in increasing the energy yield and, hence, fuel utilization from once-through fuel irradiation. This report evaluates the potential increase in fuel utilization of light water reactor cores operating on a once-through cycle assuming 0.2% enrichment plant tails assay. This evaluation is based on a large number of survey calculations using techniques which were verified by more detailed calculations of several core concepts. It is concluded that the maximum fuel utilization which could be achieved by practical once-through pressurized light water reactor cores with either uranium or thorium is about 17 MWYth/ST U3O8 (Megawatt Years Thermal per Short Ton of U3O8). This is about 50% higher than that of current commercial light water reactor cores. Achievement of this increased fuel utilization would require average fuel burnup beyond 50,000 MWD/MT and incorporation of the following design features to reduce parasitic losses of neutrons: reflector blankets to utilize neutrons that would otherwise leak out of the core; fuel management practices in which a smaller fraction of the core is replaced at each refueling; and neutron economic reactivity control, such as movable fuel control rather than soluble boron control. For a hypothetical situation in which all neutron leakage and parasitic losses are eliminated and fuel depletion is not limited by design considerations, a maximum fuel utilization of about 20 MWYth/ST U3O8 is calculated for either uranium or thorium. It is concluded that fuel utilization for comparable reactor designs is better with uranium fuel than with thorium fuel for average fuel depletions of 30,000 to 35,000 MWD/MT which are characteristic of present light water reactor cores

  15. A Survey of Simulation Utilization in Anesthesiology Residency Programs in the United States.

    Science.gov (United States)

    Rochlen, Lauryn R; Housey, Michelle; Gannon, Ian; Tait, Alan R; Naughton, Norah; Kheterpal, Sachin

    2016-06-01

    Given the evolution of competency-based education and evidence supporting the benefits of incorporating simulation into anesthesiology residency training, simulation will likely play an important role in the training and assessment of anesthesiology residents. Currently, there are little data available regarding the current status of simulation-based curricula across US residency programs. In this study, we assessed simulation-based training and assessment in US anesthesiology programs using a survey designed to elicit information regarding the type, frequency, and content of the simulation courses offered at the 132 Accreditation Council of Graduate Medical Education-certified anesthesiology training programs. The response rate for the survey was 66%. Although most of the responding programs offered simulation-based courses for interns and residents and during CA-1 orientation, the curriculum varied greatly among programs. Approximately 40% of responding programs use simulation for resident assessment and remediation. The majority of responding programs favored standard simulation-based training as part of residency training (89%), and the most common perceived obstacles to doing so were time, money, and human resources. The results from this survey highlight that there are currently large variations in simulation-based training and assessment among training programs. It also confirms that many program directors feel that standardizing some components of simulation-based education and assessment would be beneficial. Given the positive impact simulation has on skill retention and operating room preparedness, it may be worthwhile to consider developing a standard curriculum. PMID:26934609

  16. A Survey of Simulation Utilization in Anesthesiology Residency Programs in the United States.

    Science.gov (United States)

    Rochlen, Lauryn R; Housey, Michelle; Gannon, Ian; Tait, Alan R; Naughton, Norah; Kheterpal, Sachin

    2016-06-01

    Given the evolution of competency-based education and evidence supporting the benefits of incorporating simulation into anesthesiology residency training, simulation will likely play an important role in the training and assessment of anesthesiology residents. Currently, there are little data available regarding the current status of simulation-based curricula across US residency programs. In this study, we assessed simulation-based training and assessment in US anesthesiology programs using a survey designed to elicit information regarding the type, frequency, and content of the simulation courses offered at the 132 Accreditation Council of Graduate Medical Education-certified anesthesiology training programs. The response rate for the survey was 66%. Although most of the responding programs offered simulation-based courses for interns and residents and during CA-1 orientation, the curriculum varied greatly among programs. Approximately 40% of responding programs use simulation for resident assessment and remediation. The majority of responding programs favored standard simulation-based training as part of residency training (89%), and the most common perceived obstacles to doing so were time, money, and human resources. The results from this survey highlight that there are currently large variations in simulation-based training and assessment among training programs. It also confirms that many program directors feel that standardizing some components of simulation-based education and assessment would be beneficial. Given the positive impact simulation has on skill retention and operating room preparedness, it may be worthwhile to consider developing a standard curriculum.

  17. Continuing education program evaluation for course improvement, participant effect and utilization in clinical practice.

    Science.gov (United States)

    Faulk, L G

    1984-04-01

    An evaluation of a single continuing education (CE) program was conducted by the presenter to assess impact of the offering and gather information for course improvement. The purpose of this evaluation was to document if and to what extent the learners attained the program's objectives and also to systematically examine the program to see how it might be improved. The third purpose was to document if participants' interest was stimulated by the program and if they actually used the information in clinical practice or at least found it helpful. Fifty-five nurses participated in completing a pretest and posttest, reactionnaire at the conclusion of the program and follow-up questionnaire. Participants made significantly (p less than .05) better scores on the posttests as compared to the pretest. On the evaluation form, 98% of the nurses responded that they had learned new facts, and 75% indicated that information was moderately new. In addition, a slight majority (58%) responded that they changed their beliefs about assertiveness. Of returned follow-up questionnaires, 95% told others about the program, and 59% read articles. All nurses indicated they had found the information useful, and 87% had actually used the information in clinical practice. This study documents a method for CE administrators and educators to evaluate the impact of CE and provide information for course improvement. The evaluation supports the program's worth. Participants benefited in terms of knowledge and interest. In addition, program strengths/weaknesses were identified. PMID:6325622

  18. Evaluation of Access, a Primary Care Program for Indigent Patients: Inpatient and Emergency Room Utilization.

    Science.gov (United States)

    Davidson, Richard A.; Giancola, Angela; Gast, Andrea; Ho, Janice; Waddell, Rhondda

    2003-01-01

    Evaluated the impact of Accessing Community Care through Eastside Social Services (ACCESS), a program that provided indigent patients with free primary care, on inpatient admissions, emergency room (ER) visits, and subsequent charges. Data on 19 people before and after program enrollment showed significant decreases in ER visits following…

  19. Utilizing Technology to Improve the Administration of Instructional Physical Activity Programs in Higher Education

    Science.gov (United States)

    Melton, Bridget; Burdette, Trey

    2011-01-01

    The purpose of this article is to provide examples of how technology is being used in one university to increase the organization and effectiveness of instructional physical activity programs (IPAPs). The article outlines ways in which technology can organize materials for students, instructors, and programs. Additionally, the article describes…

  20. Empowering Teachers to Create Educational Software: A Constructivist Approach Utilizing Etoys, Pair Programming and Cognitive Apprenticeship

    Science.gov (United States)

    Lee, Young-Jin

    2011-01-01

    This study investigates whether a visual programming environment called Etoys could enable teachers to create software applications meeting their own instructional needs. Twenty-four teachers who participated in the study successfully developed their own educational computer programs in the educational technology course employing cognitive…

  1. 42 CFR 423.153 - Drug utilization management, quality assurance, and medication therapy management programs (MTMPs).

    Science.gov (United States)

    2010-10-01

    ... medication therapy management programs (MTMPs). 423.153 Section 423.153 Public Health CENTERS FOR MEDICARE... management, quality assurance, and medication therapy management programs (MTMPs). (a) General rule. Each...) Must offer a minimum level of medication therapy management services for each beneficiary enrolled...

  2. Utilizing the Theoretical Framework of Collective Identity to Understand Processes in Youth Programs

    Science.gov (United States)

    Futch, Valerie A.

    2016-01-01

    This article explores collective identity as a useful theoretical framework for understanding social and developmental processes that occur in youth programs. Through narrative analysis of past participant interviews (n = 21) from an after-school theater program, known as "The SOURCE", it was found that participants very clearly describe…

  3. Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources

    Energy Technology Data Exchange (ETDEWEB)

    1980-07-01

    Progress is reported in this multidisciplinary research program. Genetic selection of superior trees, physiological basis of vigor, tissue culture systems leading to cloning of diploid and haploid cell lines are discussed in the Program A report. The physiological basis of enhanced oleoresin formation in southern pines when treated with sublethal concentrations of the herbicide paraquat was investigated in Program B. In Program C, metabolic changes in the stems of slash pine, in vivo, after application with paraquat were determined. The use of phdoem and xylem tissue slices as a laboratory model for studying paraquat associated- and normal-terpene synthesis in pines is discussed. The biochemistry and physiology of methane formation from cellulose during anaerobic fermentation are discussed in the Program D report. (DMC)

  4. DOE Voluntary Partnership Program with Utilities and Local Governments Supports the Design of New Data Access Solutions

    Energy Technology Data Exchange (ETDEWEB)

    Shah, Monisha; Burr, Andrew; Schulte, Andrew; Field-Macumber, Kristin; Cochran-Hameen, Erica; Marion, Flore

    2016-08-26

    The Better Buildings Energy Data Accelerator (BBEDA) is a unique effort that has supported 22 pairs of local governments and their utility companies to help building owners gain access to their whole-building energy data. Municipal and Utility BBEDA Partners committed to develop streamlined and easy-to-use solutions to provide whole-building energy data, especially for multitenant commercial buildings, by the end of 2015. As a result, building owners would be able to make data-driven decisions about their buildings by utilizing readily available energy consumption data for entire buildings. Traditionally, data access was difficult to implement due to technical barriers and the lack of clear value propositions for the utilities. During the past two years, BBEDA has taken a hands-on approach to overcome these barriers by offering a platform for the partners to discuss their challenges and solutions. Customized support was also provided to Partners building their local strategies. Based on the lessons learned from the partners, BBEDA developed a final toolkit with guiding documents that addressed key barriers and served as a resource for the other cities and utilities attempting to establish whole-building data access, including an exploration of opportunities to apply the whole-building data to various aspects of utility demand-side management (DSM) programs. BBEDA has been a catalyst for market transformation by addressing the upstream (to efficiency implementation) barrier of data access, demonstrated through the success of the BBEDA partners to address policy, engagement, and technical hurdles and arrive at replicable solutions to make data access a standard practice nationwide. As a result of best practices identified by the BBEDA, 18 utilities serving more than 2.6 million commercial customers nationwide will provide whole-building energy data access to building owners by 2017. This historic expansion of data accessibility will increase building energy

  5. Northeast Utilities' participation in the Kaman/NASA wind power program

    Science.gov (United States)

    Lotker, M.

    1975-01-01

    The role of Northeast Utilities in the Kaman/NASA large wind generator study is reviewed. The participation falls into four principal areas: (1) technical assistance; (2) economic analysis; (3) applications; and (4) institutional and legal. A model for the economic viability of wind power is presented.

  6. 77 FR 10718 - Request for Proposals: 2012 Hazardous Fuels Woody Biomass Utilization Grant Program

    Science.gov (United States)

    2012-02-23

    ... above or contact Susan LeVan-Green, Program Manager of the Technology Marketing Unit, Madison, WI (608..., including holidays. ] Correction In the Federal Register of February 6, 2012, in FR DOC 2012-2545 on...

  7. Thorium utilization program progress report, July 1, 1975--September 30, 1976

    Energy Technology Data Exchange (ETDEWEB)

    Lotts, A.L.; Kasten, P.R.

    1977-07-01

    Status of the following tasks is reported: program management and analysis; reprocessing development; refabrication development; waste treatment; fuels irradiation and examination; HTGR fuel recycle demonstration facility; hot engineering test project; and cold prototype refabrication development. (LK)

  8. Benefit-cost analysis of DOE's Current Federal Program to increase hydrothermal resource utilization. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-12-10

    The impact of DOE's Current Federal Program on the commercialization of hydrothermal resources between 1980 and 2000 is analyzed. The hydrothermal resources of the United States and the types of DOE activities used to stimulate the development of these resources for both electric power and direct heat use are described briefly. The No Federal Program and the Current Federal Program are then described in terms of funding levels and the resultant market penetration estimates through 2000. These market penetration estimates are also compared to other geothermal utilization forecasts. The direct benefits of the Current Federal Program are next presented for electric power and direct heat use applications. An analysis of the external impacts associated with the additional hydrothermal resource development resulting from the Current Federal Program is also provided. Included are environmental effects, national security/balance-of-payments improvements, socioeconomic impacts and materials requirements. A summary of the analysis integrating the direct benefits, external impacts and DOE program costs concludes the report.

  9. Multidisciplinary research program directed toward utilization of solar energy through bioconversion of renewable resources. Progress report

    Energy Technology Data Exchange (ETDEWEB)

    Finnerty, W. R.

    1976-07-01

    Progress is reported in four research areas of solar bioconversion. The first program deals with the genetic selection of superior trees, physiological basis of vigor, tissue culture, haploid cell lines, and somatic hybridization. The second deals with the physiology of paraquat-induced oleoresin biogenesis. Separate abstracts were prepared for the other two program areas: biochemical basis of paraquat-induced oleoresin production in pines and biochemistry of methanogenesis. (JSR)

  10. NASA's Management and Utilization of the Small Business Innovative Research (SBIR) Program

    Science.gov (United States)

    Mexcur, Winfield Paul

    2003-01-01

    The United Space Congress established the SBIR program in 1982 for the following purposes: ( 1) Stimulate technological innovation (2) Increase private-sector commercialization derived from federal R&D (3) Use small business to meet federal R&D needs (4) Foster and encourage participation by disadvantaged persons and women in technological innovation The STTR program was established in 1992 with the additional requirement of having a small business partner with a research institution (usually a university) for the purpose of transferring intellectual property from the research institution to the small business concern for enabling a government technical need and furthering the technological development for the purpose of developing commercial products. The government of Japan has established a program that models portions of the U.S. SBIR and STTR programs. They are very interested in how NASA has been so successful in fulfilling the Congressional objectives of these programs. In particular, they want to understand the management practices and incentives that are provided to enable partnerships between business enterprises, academia and government. The speech will also focus on some of the many successful technologies (on a conceptual level) that have been developed through NASA s SBIR and STTR programs and mechanisms used to promote cooperation between small businesses, large businesses, academia and government agencies within the United States. The speech is on a conceptual level, focusing on U.S. and NASA policies and management implementation practices. No enabling technical discussion will be held.

  11. The German R&D Program for CO2 Utilization-Innovations for a Green Economy.

    Science.gov (United States)

    Mennicken, Lothar; Janz, Alexander; Roth, Stefanie

    2016-06-01

    Carbon capture and utilization (CCU) is a field of key emerging technologies. CCU can support the economy to decrease the dependency on fossil carbon raw materials, to stabilize electricity grids and markets with respect to a growing share of fluctuating renewable energy. Furthermore, it can contribute to mitigate anthropogenic CO2 emissions. The German Federal Ministry of Education and Research has provided substantial financial support for research and development projects, stimulating research, development, and innovations in the field of CO2 utilization. This review provides an overview over the most relevant funding measures in this field. Examples of successful projects demonstrate that CCU technologies are already economically viable or technologically ready for industrial application. CCU technologies as elements of a future "green economy" can contribute to reach the ambitious German sustainability targets with regard to climate protection as well as raw material productivity. PMID:27094264

  12. The German R&D Program for CO2 Utilization-Innovations for a Green Economy.

    Science.gov (United States)

    Mennicken, Lothar; Janz, Alexander; Roth, Stefanie

    2016-06-01

    Carbon capture and utilization (CCU) is a field of key emerging technologies. CCU can support the economy to decrease the dependency on fossil carbon raw materials, to stabilize electricity grids and markets with respect to a growing share of fluctuating renewable energy. Furthermore, it can contribute to mitigate anthropogenic CO2 emissions. The German Federal Ministry of Education and Research has provided substantial financial support for research and development projects, stimulating research, development, and innovations in the field of CO2 utilization. This review provides an overview over the most relevant funding measures in this field. Examples of successful projects demonstrate that CCU technologies are already economically viable or technologically ready for industrial application. CCU technologies as elements of a future "green economy" can contribute to reach the ambitious German sustainability targets with regard to climate protection as well as raw material productivity.

  13. The potential cost savings of implementing an inter-utility NOx trading program

    International Nuclear Information System (INIS)

    Technology based standards such as RACT, which require the installation of a (R)easonably (A)vailable (C)ontrol (T)echnology on a boiler by boiler basis have been the dominant factor driving electric utility NOx compliance plans. In this paper, the authors examine the cost savings of implementing NOx trading, an alternative market based strategy for reducing the emissions of nitrogen oxides (NOx) to achieve NOx reduction goals set under Title IV of the 1990 Clean Air Act. In order to estimate the potential cost savings of inter-utility NOx trading, they use a combinatorial optimization approach to identify boiler retrofits and operating parameters which yield efficient (i.e., the most cost effective) NOx abatement strategies. In their formulation, annual emissions at individual boilers which are expensive to abate may exceed RACT levels by up to a factor of two thus allowing for trades with boilers which can abate in a more cost effective manner. They constrain total emissions in a trading region to be at or below the level obtained had all the boilers adopted RACT. Increasing the flexibility with which trades can occur has two main effects: (1) the cost effectiveness of meeting an aggregate reduction goal increases and (2) the spatial distribution of emissions shift relative to what it would have been under a strict RACT based compliance strategy. They estimate the magnitude of these effects for two Eastern electric utilities making intra- and inter-utility NOx trades. Results indicate that the cost effectiveness of meeting RACT level reduction can be increased by as much as 38% under certain trading regimes

  14. Impact of a new reimbursement program on hepatitis B antiviral medication cost and utilization in Beijing, China.

    Directory of Open Access Journals (Sweden)

    Qian Qiu

    Full Text Available BACKGROUND: Hepatitis B virus (HBV infection is a significant clinical and financial burden for chronic hepatitis B (CHB patients. In Beijing, China, partial reimbursement on antiviral agents was first implemented for the treatment of CHB patients in July 1, 2011. AIMS: In this study, we describe the medical cost and utilization rates of antiviral therapy for CHB patients to explore the impact of the new partial reimbursement policy on the medical care cost, the composition, and antivirals utilization. METHODS: Clinical and claims data of a retrospective cohort of 92,776 outpatients and 2,774 inpatients with non-cirrhotic CHB were retrieved and analyzed from You'an Hospital, Beijing between February 14, 2008 and December 31, 2012. The propensity score matching was used to adjust factors associated with the annual total cost, including age, gender, medical insurance type and treatment indicator. RESULTS: Compared to patients who paid out-of-pocket, medical cost, especially antiviral costs increased greater among patients with medical insurance after July 1, 2011, the start date of reimbursement policy. Outpatients with medical insurance had 16% more antiviral utilization; usage increased 3% among those who paid out-of-pocket after the new partial reimbursement policy was implemented. CONCLUSIONS: Direct medical costs and antiviral utilization rates of CHB patients with medical insurance were higher than those from paid out-of-pocket payments, even after adjusting for inflation and other factors. Thus, a new partial reimbursement program may positively optimize the cost and standardization of antiviral treatment.

  15. Optimizing antimicrobial therapy in critically ill patients

    Directory of Open Access Journals (Sweden)

    Vitrat V

    2014-10-01

    Full Text Available Virginie Vitrat,1 Serge Hautefeuille,2 Cécile Janssen,1 David Bougon,2 Michel Sirodot,2 Leonardo Pagani1,3 1Antimicrobial Stewardship Program, Infectious Diseases Unit, 2Intensive Care Unit, Annecy-Genevois Hospital Center (CHANGE, Annecy, France; 3Infectious Diseases Unit, Bolzano Central Hospital, Bolzano, Italy Abstract: Critically ill patients with infection in the intensive care unit (ICU would certainly benefit from timely bacterial identification and effective antimicrobial treatment. Diagnostic techniques have clearly improved in the last years and allow earlier identification of bacterial strains in some cases, but these techniques are still quite expensive and not readily available in all institutions. Moreover, the ever increasing rates of resistance to antimicrobials, especially in Gram-negative pathogens, are threatening the outcome for such patients because of the lack of effective medical treatment; ICU physicians are therefore resorting to combination therapies to overcome resistance, with the direct consequence of promoting further resistance. A more appropriate use of available antimicrobials in the ICU should be pursued, and adjustments in doses and dosing through pharmacokinetics and pharmacodynamics have recently shown promising results in improving outcomes and reducing antimicrobial resistance. The aim of multidisciplinary antimicrobial stewardship programs is to improve antimicrobial prescription, and in this review we analyze the available experiences of such programs carried out in ICUs, with emphasis on results, challenges, and pitfalls. Any effective intervention aimed at improving antibiotic usage in ICUs must be brought about at the present time; otherwise, we will face the challenge of intractable infections in critically ill patients in the near future. Keywords: ICU, antimicrobial therapies, antimicrobial stewardship, pharmacokinetics, pharmacodynamics, antimicrobial resistance, early diagnosis

  16. Reverse Programmed SONOS Memory Technique for 0.18μm Embedded Utilization

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A 4 Mb embedded silicon-oxide-nitride-oxide-silicon (SONOS) memory was developed with a 0.18 μm CMOS logic compatible technology. A reverse programming array architecture was proposed to reduce the chip area, enhance the operating window, and increase the read speed. The charge distribution was analyzed to optimize the programming and erase conditions considering both the operating speed and the endurance performance. The final test chip has a good endurance of 105 cycles and a data retention time of at least 10 years.

  17. Implementation of the utilization program for the fuel elements of the Atucha I nuclear power plant

    International Nuclear Information System (INIS)

    The programming operation for the use of the fuel elements in the Atucha-1 nuclear power plant was initially under the responsibility of the KWU Company, as part of the services rendered due for the manufacturing of said elements. This job was done with the help of the TRISIC program, developed in the early seventies by CNEA and SIEMENS staff. From april 21, 1979 on, CNEA took over the responsibility and strategy of the interchange of fuel elements. The several stages carried out for the implementation of this service are detailed. (M.E.L.)

  18. Antimicrobial peptides.

    Science.gov (United States)

    Zhang, Ling-Juan; Gallo, Richard L

    2016-01-11

    Antimicrobial peptides and proteins (AMPs) are a diverse class of naturally occurring molecules that are produced as a first line of defense by all multicellular organisms. These proteins can have broad activity to directly kill bacteria, yeasts, fungi, viruses and even cancer cells. Insects and plants primarily deploy AMPs as an antibiotic to protect against potential pathogenic microbes, but microbes also produce AMPs to defend their environmental niche. In higher eukaryotic organisms, AMPs can also be referred to as 'host defense peptides', emphasizing their additional immunomodulatory activities. These activities are diverse, specific to the type of AMP, and include a variety of cytokine and growth factor-like effects that are relevant to normal immune homeostasis. In some instances, the inappropriate expression of AMPs can also induce autoimmune diseases, thus further highlighting the importance of understanding these molecules and their complex activities. This Primer will provide an update of our current understanding of AMPs. PMID:26766224

  19. Utility spent-fuel management reaction to DOE [U.S. Department of Energy] waste program reassessment

    International Nuclear Information System (INIS)

    Citing in general a concern over the nuclear waste program's lack of progress and, more specifically, program schedule slippages, management structure problems, and lack of integrated contractor efforts, the U.S. Department of Energy (DOE) was directed by Congress to report on how it plans to resolve these concerns and put the program back on track. In response to this request, DOE's Report to Congress on Reassessment of the Civilian Radioactive Waste Management Program was published on November 29, 1989. This report proposed a three-point action plan, which included rescheduling of the repository operation to a more realistic 2010, use of a monitored retrievable storage (MRS) to meet DOE's 1998 fuel receipt commitment, and management restructuring. While Duke Power Company applauds DOE's dual effort to establish a realistic repository schedule and carry out their 1998 fuel receipt obligation, it would appear that the only hope for the utility industry to avoid another 20 yr or more of continued on-site spent-fuel storage is for DOE or the nuclear waste negotiator to find a willing MRS host state. This paper examines the current status of Duke's spent-fuel storage program and discusses some major changes to long-term spent-fuel storage strategies that will likely be necessary should no off-site storage relief be available until 2010

  20. Antimicrobial activity of amazonian medicinal plants

    OpenAIRE

    Oliveira, Amanda A; Segovia, Jorge FO; Sousa, Vespasiano YK; Mata, Elida CG; Gonçalves, Magda CA; Bezerra, Roberto M; Junior, Paulo OM; Kanzaki, Luís IB

    2013-01-01

    Objectives The aqueous extracts of currently utilized Amazonian medicinal plants were assayed in vitro searching for antimicrobial activity against human and animal pathogenic microorganisms. Methods Medium resuspended lyophilized aqueous extracts of different organs of Amazonian medicinal plants were assayed by in vitro screening for antimicrobial activity. ATCC and standardized microorganisms obtained from Oswaldo Cruz Foundation/Brazil were individually and homogeneously grown in agar plat...

  1. The Danish large wind turbine program. [feasibility of wind power in a utility grid

    Science.gov (United States)

    Pederson, B. M.

    1979-01-01

    A brief description of the Danish wind energy program and its present status is given. Results and experiences from tests on the Gedser windmill (200 kW) are presented. The key results are presented from the preliminary design study and detailed design of two new WECS (630 kW each) is described.

  2. 32 CFR 199.15 - Quality and utilization review peer review organization program.

    Science.gov (United States)

    2010-07-01

    ... program where required by statute, such as inpatient mental health services in excess of 30 days in any... hospital shall provide to the PRO the records required for the review by the close of business of the day... hospital continues to fail to provide the records shall not be counted for purposes of the two-day...

  3. Strategic plan for the utilization of remote sensing technologies in the Environmental Restoration Program

    International Nuclear Information System (INIS)

    The objectives of the Environmental Restoration (ER) Remote Sensing and Special Surveys Program are to apply state-of-the-art remote sensing and geophysical technologies and to manage routine and remotely-sensed examinations of the Oak Ridge Reservation (ORR), the Paducah Gaseous Diffusion Plant (PGDP), the Portsmouth Gaseous Diffusion Plant (PORTS), and their adjacent off-site areas. Repeated multispectral scanner (MSS) imagery, gamma, and photographic surveys will allow monitoring of the degradation that might occur in waste containment vessels and monitoring (at a later stage in the remediation life cycle) of improvements from restoration efforts and cleanup. These technologies, in combination with geophysical surveys, will provide an effective means for identifying unknown waste sites and contaminant transport pathways. All of the data will be maintained in a data base that will be accessible to site managers in the ER Program. The complete analysis of collected data will provide site-specific data to the ER Program for characterizing and monitoring ER Program hazardous waste sites

  4. Strategic plan for the utilization of remote sensing technologies in the environmental restoration program

    International Nuclear Information System (INIS)

    The objectives of the Environmental Restoration (ER) Remote Sensing and Special Surveys Program are to apply state-of-the-art remote sensing and geophysical technologies and to manage routine and remotely-sensed examinations of the Oak Ridge Reservation (ORR), the Paducah Gaseous Diffusion Plant (PGDP), the Portsmouth Gaseous Diffusion Plant (PORTS), and their adjacent off-site areas. Repeated multispectral scanner (MSS) imagery, gamma, and photographic surveys will allow monitoring of the degradation that might occur in waste containment vessels and monitoring (at a later stage in the remediation life cycle) of improvements from restoration efforts and cleanup. These technologies, in combination with geophysical surveys, will provide an effective means for identifying unknown waste sites and contaminant transport pathways. All of the data will be maintained in a data base that will be accessible to site managers in the ER Program. The complete analysis of collected data will provide site-specific data to the ER Program for characterizing and monitoring ER Program hazardous waste sites

  5. Strategic plan for the utilization of remote sensing technologies in the environmental restoration program

    Energy Technology Data Exchange (ETDEWEB)

    King, A.D.; Doll, W.E.; Durfee, R.C.; Luxmoore, R.J.; Conder, S.R.; Nyquist, J.E.

    1993-12-01

    The objectives of the Environmental Restoration (ER) Remote Sensing and Special Surveys Program are to apply state-of-the-art remote sensing and geophysical technologies and to manage routine and remotely-sensed examinations of the Oak Ridge Reservation (ORR), the Paducah Gaseous Diffusion Plant (PGDP), the Portsmouth Gaseous Diffusion Plant (PORTS), and their adjacent off-site areas. Repeated multispectral scanner (MSS) imagery, gamma, and photographic surveys will allow monitoring of the degradation that might occur in waste containment vessels and monitoring (at a later stage in the remediation life cycle) of improvements from restoration efforts and cleanup. These technologies, in combination with geophysical surveys, will provide an effective means for identifying unknown waste sites and contaminant transport pathways. All of the data will be maintained in a data base that will be accessible to site managers in the ER Program. The complete analysis of collected data will provide site-specific data to the ER Program for characterizing and monitoring ER Program hazardous waste sites.

  6. Strategic plan for the utilization of remote sensing technologies in the Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    King, A.D.; Doll, W.E.; Durfee, R.C.; Luxmoore, R.J.; Conder, S.R.; Nyquist, J.E.

    1994-03-01

    The objectives of the Environmental Restoration (ER) Remote Sensing and Special Surveys Program are to apply state-of-the-art remote sensing and geophysical technologies and to manage routine and remotely-sensed examinations of the Oak Ridge Reservation (ORR), the Paducah Gaseous Diffusion Plant (PGDP), the Portsmouth Gaseous Diffusion Plant (PORTS), and their adjacent off-site areas. Repeated multispectral scanner (MSS) imagery, gamma, and photographic surveys will allow monitoring of the degradation that might occur in waste containment vessels and monitoring (at a later stage in the remediation life cycle) of improvements from restoration efforts and cleanup. These technologies, in combination with geophysical surveys, will provide an effective means for identifying unknown waste sites and contaminant transport pathways. All of the data will be maintained in a data base that will be accessible to site managers in the ER Program. The complete analysis of collected data will provide site-specific data to the ER Program for characterizing and monitoring ER Program hazardous waste sites.

  7. A Perspective for Developing Strategies for Utilizing New Communication Technologies in Public Relations Programs.

    Science.gov (United States)

    Ledingham, John A.; Masel-Walters, Lynne

    Based on a definition of public relations that recognizes the field as a purposeful management function, this paper provides a perspective on public relations to help practitioners develop strategies for the use of new media forms in public relations programs. The paper begins with a historical review of mass media effects research and proceeds…

  8. Organizing a Special Education Program Utilizing the Theory Z Model of Management.

    Science.gov (United States)

    Lindeman, David P.; And Others

    An alternative management model was implemented to increase teacher productivity in an institutional school for 185 mildly to severely mentally retarded children. The model included three components: a management structure that allowed for problem solving while still motivating staff; an inservice program for staff; and an evaluation system to…

  9. Nursing Student Retention in Associate Degree Nursing Programs Utilizing a Retention Specialist

    Science.gov (United States)

    Schrum, Ronna A.

    2014-01-01

    The purpose of this study was to examine specific variables associated with nursing student retention in Associate Degree Nursing (ADN) Programs. Jeffreys (2004) Nursing Undergraduate Retention and Success (NURS) conceptual model provided the framework for this descriptive correlational study. One hundred sixty eight pre-licensure associate degree…

  10. Green power programs in Canada : 2002 : Overview of Government green power policies, utility green power development programs, green power and certificate marketing initiatives, and their benefits

    International Nuclear Information System (INIS)

    Green power is generally defined as electricity produced from renewable sources, and whose production has low adverse impacts on the environment, human health and communities. Green power has near-zero greenhouse gas (GHG) emissions and includes sources such as wind, hydro, and solar power. Green power offers several environmental benefits, as well as the enhancement of energy security, regional development, economic diversification and the creation of skilled jobs. There are four categories of programs related to green power development in Canada: government green power policies, utility green power development programs, green power marketing initiatives, and green power certificate marketing initiatives. Most of the activities associated with these four categories in 2002 were discussed in this report. However, difficulties with quantification prevented the inclusion of some green power activities in the report, such as (1) the generation of green power not certified or identified by the generator as green power, (2) industry or residential self-generation, (3) net metering, and (4) small government programs. Each category was presented in detail. The information included in the report was based on surveys sent to each program proponent. Follow-up communications and other publicly available information was also included. New programs operating in 2003 or currently under development were listed. refs., 8 tabs

  11. Pilot study investigating the utility of a specialized online symptom management program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome as compared to an online meditation program

    Directory of Open Access Journals (Sweden)

    Arroll MA

    2014-09-01

    Full Text Available Megan A Arroll, Elizabeth A Attree, Claire L Marshall, Christine P DanceyChronic Illness Research Team, School of Psychology, University of East London, London, UKBackground: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS is a long-term, debilitating condition that impacts numerous areas of individuals' lives. The two predominant treatment options for ME/CFS are cognitive behavioral therapy and graded exercise therapy; however, many people have found these techniques unacceptable or even damaging. This pilot study aimed to evaluate the utility of a specialized online symptom management program for ME/CFS in comparison to an online meditation program in an effort to ascertain whether this tool could be a further option for those with ME/CFS.Methods: This experimental design consisted of two interventions: a specialized online symptoms management program (N=19 and a control intervention based on an online meditation website (N=9. A battery of questionnaires, including measures of multidimensional fatigue, illness-specific symptoms, perceived control, and mindful awareness, were completed before the participants commenced use of the programs and following 8 weeks' use.Results: Significant differences were found in the areas of chance and powerful others' locus of control, and sleeping difficulties, but not in ME/CFS symptomatology overall.Conclusion: The specialized online program described in this study warrants further investigation, as it appears to influence perceived control and key ME/CFS symptoms over time.Keywords: ME/CFS, perceived control, sleep, outcomes, online intervention

  12. A case study in technology utilization: Industrial products and practices. [summary of benefits to national economy resulting from space programs

    Science.gov (United States)

    1973-01-01

    In pursuit of such missions as Apollo, the National Aeronautics and Space Administration has called into being unique equipment that obviously has little direct application beyond the achievement of mission objectives. Yet, to assume that further direct application of space program hardware is somehow a measure of the industrial benefits accruing to the nation is to misunderstand how the creation of new technology affects modern industrial capability. This document presents a profile of the significant ways in which technological developments in response to aerospace mission requirements have been coupled into industrial practice, with the result being that improved products and processes are now being utilized to benefit the nation.

  13. Current status of nuclear research reactor management and utilization program in Thailand

    Energy Technology Data Exchange (ETDEWEB)

    Aramrattana, M. [Deputy Secretary General, Office of Atomic Energy for Peace, Chatuchak, Bangkok (Thailand); Busamongkol, Y.

    1999-08-01

    The TRR1/M1 is the first research reactor and has been in operational for more than 20 years. During the three decades of research reactor operation in Thailand the utilization of research reactor have been broadened in different fields such as agriculture, medicine and industry. Limitation on utilization of the existing reactor in various fields has led to establishing of a new nuclear research center, Ongkharak Nuclear Research Center (ONRC). The ONRC comprises three major facilities, namely Reactor Island, Isotope Production Facility and Waste Processing and Storage Facility. The reactor itself is a 10 MW TRIGA-type fuels, moderated and cooled by light water with beryllium and heavy water as the reflectors. It is a multi-purpose reactor consisting of different facilities inside and around the core for radioisotope production, medical and industrial uses; and for beam experiments such as High Resolution Powder Diffractometry (HRPD), Neutron Radiography (NR), Prompt Gamma Neutron Activation Analysis (PGNAA), and Boron Neutron Capture Therapy (BNCT). The center is expected to be operational by year 2001. (author)

  14. IMPROVEMENTS IN HANFORD TRANSURANIC (TRU) PROGRAM UTILIZING SYSTEMS MODELING AND ANALYSES

    Energy Technology Data Exchange (ETDEWEB)

    UYTIOCO EM

    2007-11-12

    Hanford's Transuranic (TRU) Program is responsible for certifying contact-handled (CH) TRU waste and shipping the certified waste to the Waste Isolation Pilot Plant (WIPP). Hanford's CH TRU waste includes material that is in retrievable storage as well as above ground storage, and newly generated waste. Certifying a typical container entails retrieving and then characterizing it (Real-Time Radiography, Non-Destructive Assay, and Head Space Gas Sampling), validating records (data review and reconciliation), and designating the container for a payload. The certified payload is then shipped to WIPP. Systems modeling and analysis techniques were applied to Hanford's TRU Program to help streamline the certification process and increase shipping rates.

  15. New Jersey state information handbook: Formerly Utilized Sites Remedial Action Program

    International Nuclear Information System (INIS)

    Under the implied authority of the Atomic Energy Act of 1954, as amended, radiological surveys and research work has been conducted to determine radiological conditions at former MED/AEC sites. As of this time, 31 sites in 13 states have been identified that require or may require remedial action. This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of New Jersey. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations. The loose-leaf format used in these volumes will allow the material to be updated periodically as the Remedial Action Program progresses

  16. New Jersey state information handbook: Formerly Utilized Sites Remedial Action Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-31

    Under the implied authority of the Atomic Energy Act of 1954, as amended, radiological surveys and research work has been conducted to determine radiological conditions at former MED/AEC sites. As of this time, 31 sites in 13 states have been identified that require or may require remedial action. This volume is one of a series produced under contract with DOE, Office of Nuclear Waste Management, by POLITECH CORPORATION to develop a legislative and regulatory data base to assist the FUSRAP management in addressing the institutional and socioeconomic issues involved in carrying out the Remedial Action Program. This Information Handbook series contains information about all relevant government agencies at the Federal and state levels, the pertinent programs they administer, each affected state legislature, and current Federal and state legislative and regulatory initiatives. This volume is a compilation of information about the state of New Jersey. It contains: a description of the state executive branch structure; a summary of relevant state statutes and regulations; a description of the structure of the state legislature, identification of the officers and committee chairmen, and a summary of recent relevant legislative action; and the full text of relevant statutes and regulations. The loose-leaf format used in these volumes will allow the material to be updated periodically as the Remedial Action Program progresses.

  17. Assessing the effectiveness of a place-based conservation education program by applying utilization-focused evaluation

    Science.gov (United States)

    Flowers, Alice Blood

    Lack of personal connection to the natural world by most American youth builds reason for assessing effectiveness of conservation education programs. Place-based learning is important in helping youth understand how their personal and societal well-being are linked and dependent upon their local habitats. Across Montana 2277 students in grades 3--10 participate in an interactive year long fishing education program with their teachers called Hooked on Fishing (HOF). The purpose of my study was to assess the effectiveness of HOF, a place-based conservation education program established in 1996, and modeled after the national Hooked on Fishing, Not on Drugs program. Using a quasi-experimental nonequivalent group study design, students received a pre-survey during the beginning of the program, a post-survey after the program, and an extended post-survey 12 to 14 weeks later. Teachers voluntarily participated in an Internet survey during May 2006, and program instructors voluntarily participated in a structured open-ended telephone interview in June 2006. A key component of my study was the decision to conduct the evaluation process using an approach which included stakeholders in the development of the instruments to measure student outcomes. This approach is called utilization-focused evaluation and was developed by Michael Q. Patton. The motive of this approach is to promote the usability of the evaluation results. The results are considered to have a better chance to be applied by the program stakeholders to not only gauge program effectiveness, but to be used to improve the program. Two research questions were: (1) does the frequency of outdoor experiences have significant affects on students' knowledge, skills, attitudes, and intended stewardship behaviors; and (2) does improved knowledge of local natural resources have significant affects on students' skills, attitudes and intended stewardship behavior. Nonparametric statistical analyses calculated statistical

  18. Antimicrobial Stewardship in Acute Care Centres: A Survey of 68 Hospitals in Quebec

    Directory of Open Access Journals (Sweden)

    Vincent Nault

    2008-01-01

    Full Text Available BACKGROUND: Antimicrobial stewardship programs (ASPs and quantitative monitoring of antimicrobial use are required to ensure that antimicrobials are used appropriately in the acute care setting, and have the potential to reduce costs and limit the spread of antimicrobial-resistant organisms and Clostridium difficile. Currently, it is not known what proportion of Quebec hospitals have an ASP and/or monitor antimicrobial use.

  19. Utilizing the Scientist as Teacher Through the Initiating New Science Partnerships in Rural Education (INSPIRE) Program

    Science.gov (United States)

    Pierce, D.; McNeal, K. S.; Radencic, S.

    2011-12-01

    The presence of a scientist or other STEM expert in secondary school science classroom can provide fresh new ideas for student learning. Through the Initiating New Science Partnerships in Rural Education (INSPIRE) program sponsored by NSF Graduate STEM Fellows in K-12 Education (GK-12), scientists and engineers at Mississippi State University work together with graduate students and area teachers to provide hands-on inquiry-based learning to middle school and high school students. Competitively selected graduate fellows from geosciences, physics, chemistry, and engineering spend ten hours per week in participating classrooms for an entire school year, working as a team with their assigned teacher to provide outstanding instruction in science and mathematics and to serve as positive role models for the students. We are currently in the second year of our five-year program, and we have already made significant achievements in science and mathematics instruction. We successfully hosted GIS Day on the Mississippi State University campus, allowing participating students to design an emergency response to a simulated flooding of the Mississippi Delta. We have also developed new laboratory exercises for high school physics classrooms, including a 3-D electric field mapping exercise, and the complete development of a robotics design course. Many of the activities developed by the fellows and teachers are written into formal lesson plans that are made publicly available as free downloads through our project website. All participants in this program channel aspects of their research interests and methods into classroom learning, thus providing students with the real-world applications of STEM principles. In return, participants enhance their own communication and scientific inquiry skills by employing lesson design techniques that are similar to defining their own research questions.

  20. Space biology initiative program definition review. Trade study 2: Prototype utilization in the development of space biology hardware

    Science.gov (United States)

    Jackson, L. Neal; Crenshaw, John, Sr.; Schulze, Arthur E.; Wood, H. J., Jr.

    1989-01-01

    The objective was to define the factors which space flight hardware developers and planners should consider when determining: (1) the number of hardware units required to support program; (2) design level of the units; and (3) most efficient means of utilization of the units. The analysis considered technology risk, maintainability, reliability, and safety design requirements for achieving the delivery of highest quality flight hardware. Relative cost impacts of the utilization of prototyping were identified. The development of Space Biology Initiative research hardware will involve intertwined hardware/software activities. Experience has shown that software development can be an expensive portion of a system design program. While software prototyping could imply the development of a significantly different end item, an operational system prototype must be considered to be a combination of software and hardware. Hundreds of factors were identified that could be considered in determining the quantity and types of prototypes that should be constructed. In developing the decision models, these factors were combined and reduced by approximately ten-to-one in order to develop a manageable structure based on the major determining factors. The Baseline SBI hardware list of Appendix D was examined and reviewed in detail; however, from the facts available it was impossible to identify the exact types and quantities of prototypes required for each of these items. Although the factors that must be considered could be enumerated for each of these pieces of equipment, the exact status and state of development of the equipment is variable and uncertain at this time.

  1. Raw material utilization in slaughterhouses – optimizing expected profit using mixed-integer programming

    DEFF Research Database (Denmark)

    Jensen, Toke Koldborg; Kjærsgaard, Niels Christian

    Slaughterhouses are major players in the pork supply chain, and supply and demand must be matched in order to generate the highest profit. In particular, carcasses must be sorted in order to produce the “right” final products from the “right” carcasses. We develop a mixed-integer programming (MIP) ...... at slaughterhouses. Finally, we comment on the expected effect of variations in the raw material supply and the demand as well as future research concerning joint modelling of supply chain aspects....

  2. Interactive statistical-distribution-analysis program utilizing numerical and graphical methods

    Energy Technology Data Exchange (ETDEWEB)

    Glandon, S. R.; Fields, D. E.

    1982-04-01

    The TERPED/P program is designed to facilitate the quantitative analysis of experimental data, determine the distribution function that best describes the data, and provide graphical representations of the data. This code differs from its predecessors, TEDPED and TERPED, in that a printer-plotter has been added for graphical output flexibility. The addition of the printer-plotter provides TERPED/P with a method of generating graphs that is not dependent on DISSPLA, Integrated Software Systems Corporation's confidential proprietary graphics package. This makes it possible to use TERPED/P on systems not equipped with DISSPLA. In addition, the printer plot is usually produced more rapidly than a high-resolution plot can be generated. Graphical and numerical tests are performed on the data in accordance with the user's assumption of normality or lognormality. Statistical analysis options include computation of the chi-squared statistic and its significance level and the Kolmogorov-Smirnov one-sample test confidence level for data sets of more than 80 points. Plots can be produced on a Calcomp paper plotter, a FR80 film plotter, or a graphics terminal using the high-resolution, DISSPLA-dependent plotter or on a character-type output device by the printer-plotter. The plots are of cumulative probability (abscissa) versus user-defined units (ordinate). The program was developed on a Digital Equipment Corporation (DEC) PDP-10 and consists of 1500 statements. The language used is FORTRAN-10, DEC's extended version of FORTRAN-IV.

  3. An aging management program focused on the full utilization of existing licenses

    International Nuclear Information System (INIS)

    An Aging Management Enhancement Program has been developed to identify and mitigate the risk and uncertainties that unusual, accelerated, or previously unanticipated aging of Systems, Structures, and Components pose to the continued long term safe, economic, and reliable operation of nuclear facilities. This paper defines a process intended to enhance the understanding and control of the aging of systems, structures, and components (SSCs). The program is selective and proactive. It largely employs the experience and knowledge of personnel that have hands-on responsibility for engineering, maintaining, and operating the facility. The identification of SSCs and associated age related degradation mechanisms (ARDMs) that present future vulnerabilities to a plant allow focused actions to be implemented to remedy or abate the risk prior to the aging degradation adversely impacting plant operation. Selection of structures and components susceptible to accelerated aging degradation and appropriate remedial corrective and/or preventive actions are based on a recognized need to achieve a balance between plant safety, plant economics, and plant reliability. (author)

  4. Antimicrobial Stewardship for the Infection Control Practitioner.

    Science.gov (United States)

    Nagel, Jerod L; Kaye, Keith S; LaPlante, Kerry L; Pogue, Jason M

    2016-09-01

    Antibiotic misuse is a serious patient safety concern and a national public health priority. Years of indiscriminant antibiotic use has promoted selection for antibiotic resistant bacteria and Clostridium difficile This crisis has led to clinicians being faced with managing untreatable infections, often in the most vulnerable patient populations. This review summarizes the goals of antimicrobial stewardship programs, the essential members needed to initiate a program, various antimicrobial stewardship strategies, the role of the infection control practitioner in stewardship, barriers to its implementation and maintenance, approaches to measure the impact of a program, and the steps needed to initiate a program. PMID:27515147

  5. Selection methodology for LWR safety R and D programs and proposals. Volume III. User's manual for the multi-attribute utility package (MAUP)

    International Nuclear Information System (INIS)

    The computer program which was developed to apply the multi-attribute utility (MAU) methodology to the selection of LWR safety R and D programs and proposals is described. An overview of the MAU method is presented, followed by a description of the steps incorporated in developing individual modules for use in the multi-attribute utility package (MAUP). Each module is described complete with usage information and an example of computer output

  6. Antimicrobial Drugs in Fighting against Antimicrobial Resistance.

    Science.gov (United States)

    Cheng, Guyue; Dai, Menghong; Ahmed, Saeed; Hao, Haihong; Wang, Xu; Yuan, Zonghui

    2016-01-01

    The outbreak of antimicrobial resistance, together with the lack of newly developed antimicrobial drugs, represents an alarming signal for both human and animal healthcare worldwide. Selection of rational dosage regimens for traditional antimicrobial drugs based on pharmacokinetic/pharmacodynamic principles as well as development of novel antimicrobials targeting new bacterial targets or resistance mechanisms are key approaches in tackling AMR. In addition to the cellular level resistance (i.e., mutation and horizontal gene transfer of resistance determinants), the community level resistance (i.e., bilofilms and persisters) is also an issue causing antimicrobial therapy difficulties. Therefore, anti-resistance and antibiofilm strategies have currently become research hotspot to combat antimicrobial resistance. Although metallic nanoparticles can both kill bacteria and inhibit biofilm formation, the toxicity is still a big challenge for their clinical applications. In conclusion, rational use of the existing antimicrobials and combinational use of new strategies fighting against antimicrobial resistance are powerful warranties to preserve potent antimicrobial drugs for both humans and animals. PMID:27092125

  7. Antimicrobial Drugs in Fighting against Antimicrobial Resistance

    Directory of Open Access Journals (Sweden)

    Guyue eCheng

    2016-04-01

    Full Text Available The outbreak of antimicrobial resistance, together with the lack of newly developed antimicrobial drugs, represents an alarming signal for both human and animal healthcare worldwide. Selection of rational dosage regimens for traditional antimicrobial drugs based on pharmacokinetic/pharmacodynamic principles as well as development of novel antimicrobials targeting new bacterial targets or resistance mechanisms are key approaches in tackling AMR. In addition to the cellular level resistance (i.e., mutation and horizontal gene transfer of resistance determinants, the community level resistance (i.e., bilofilms and persisters is also an issue causing antimicrobial therapy difficulties. Therefore, anti-resistance and antibiofilm strategies have currently become research hotspot to combat antimicrobial resistance. Although metallic nanoparticles can both kill bacteria and inhibit biofilm formation, the toxicity is still a big challenge for their clinical applications. In conclusion, rational use of the existing antimicrobials and combinational use of new strategies fighting against antimicrobial resistance are powerful warranties to preserve potent antimicrobial drugs for both humans and animals.

  8. Utilizing Symbolic Programming in Analog Circuit Synthesis of Arbitrary Rational Transfer Functions

    Directory of Open Access Journals (Sweden)

    Amjad Fuad Hajjar

    2014-11-01

    Full Text Available The employment of symbolic programming in analog circuit design for system interfaces is proposed. Given a rational transfer function with a set of specifications and constraints, one may autonomously synthesize it into an analog circuit. First, a classification of the target transfer function polynomials into 14 classes is performed. The classes include both stable and unstable functions as required. A symbolic exhaustive search algorithm based on a circuit configuration under investigation is then conducted where a polynomial in hand is to be identified. For illustration purposes, a set of complete design equations for the primary rational transfer functions is obtained targeting all classes of second order polynomials based on a proposed general circuit configuration. The design consists of a single active element and four different circuit structures. Finally, an illustrative example with full analysis and simulation is presented.

  9. Program of research and development on the thorium utilization in PWRS

    International Nuclear Information System (INIS)

    Detailed investigations performed for a standard 1,300 MWe PWR show that (Th,U)O2 and (Th,Pu)O2 fuels can be inserted in 3 and 4 cycle operating schemes without modifications in the fuel assembly or core design. The most important aspects of the fuel cycle have been covered. Ex-gel pelletizing of (Th,U)O2 fuel making use of available LWR and HTR fuel manufacturing technology was demonstrated. The most promising application for Th-based fuels at present was proved to be the use of recycle plutonium in extended burnup once-through fuel cycle. The program was performed in a cooperative way between Brazilian and German partners. (orig.)

  10. Evaluation of utility home-energy-audit programs: A Wisconsin example

    Science.gov (United States)

    Grady, S.; Hirst, E.

    1982-03-01

    In February 1978, the Wisconsin Power & Light Company (WPL) offered its residential gas-space-heating customers free onsite energy audits. Between then and June 1980, WPL audited about 19 thousand homes, one-fourth of their gas customers. The audit program included an evaluation of natural gas consumption records, the need for specific weatherization measures (as determined during their energy audits), and customers reports of their demographic characteristics and recent energy conservation practices and measures. The two groups differed significantly only with respect to conservation measures; this difference was probably due, in part, to the 1978 audits. Regression equations were developd to explain natural gas use for the two heating seasons after the 1978 audit. The results showed the importance of floor area, age of house, household income, number of occupants, and temperature setting on gas use.

  11. COMET Program Training Offerings to Support S-NPP and JPSS Utilization

    Science.gov (United States)

    Abshire, W. E.; Dills, P. N.; Weingroff, M.

    2015-12-01

    Are you up to speed on how to exploit new S-NPP capabilities and products? If not, don't worry, because UCAR's COMET program has self-paced online educational materials that highlight the capabilities and applications of current and next-generation operational polar-orbiting and geostationary satellites. The COMET® Program (www.comet.ucar.edu) has long received funding from NOAA NESDIS as well as EUMETSAT and the Meteorological Service of Canada to support education and training in satellite meteorology. By partnering with experts from NOAA-NESDIS and its Cooperative Institutes, Meteorological Service of Canada, EUMETSAT, the Naval Research Laboratory and others, COMET's self-paced training stimulates greater use of current and future satellite observations and products. Right now, over 70 satellite-focused, self-paced, online materials are freely available in English via the MetEd Web site at http://meted.ucar.edu/topics/satellite. Additionally, quite a few lessons are also available in Spanish and French making training more easily accessible to an international audience. This presentation will focus on COMET's latest satellite training and education offerings that are directly applicable to data and products from the S-NPP and JPSS satellite series. A recommended set of lessons for users who wish to learn more will be highlighted, including excerpts from the newest materials on the Suomi NPP VIIRS imager and its applications, as well as advances in nighttime visible observation with the VIIRS Day-Night Band. We'll show how the lessons introduce users to the advances these systems bring to forecasting, numerical weather prediction, and environmental monitoring. Finally, new relevant training initiatives will also be presented.

  12. OPUS/PlotOPUS: An ORIGEN-S Post-Processing Utility and Plotting Program for SCALE

    International Nuclear Information System (INIS)

    The OPUS utility program produces an output file that can be used for making a variety of plots from output produced by the ORIGEN-S code that computes reactor fuel depletion, activation and fission- product buildup, and the corresponding photon and neutron source spectra. Tables containing individual and total nuclide or element concentrations, in 14 different units, may be generated as a function of time. Three classes of plot data may be produced by OPUS: (1) dominant or selected isotopes or elements, (2) photon and neutron source spectra, and (3) comparisons of selected quantities (totals or individual nuclides) between different ORIGEN-S cases. The input is designed for ease of use with self-explanatory parameter names, free-form input, and commonly used default values. The formatted output data produced by OPUS is designed to be used directly by the PlotOPUS graphics-plotting program. PlotOPUS is an interactive Visual Basic program designed for Windows 9x, 2000, and NT computers. PlotOPUS reads the formatted output data file produced by OPUS, plots the data, and will generate Windows metafile (WMF), JPEG bitmap (JPG), or Windows bitmap (BMP) files for saving the plot images. Even though it is designed to interface with PlotOPUS, the formatted OPUS output file can be easily read by other graphics packages for data visualization

  13. OPUS/PlotOPUS: An ORIGEN-S Post-Processing Utility and Plotting Program for SCALE

    Energy Technology Data Exchange (ETDEWEB)

    Gauld, I.C.

    2001-03-08

    The OPUS utility program produces an output file that can be used for making a variety of plots from output produced by the ORIGEN-S code that computes reactor fuel depletion, activation and fission- product buildup, and the corresponding photon and neutron source spectra. Tables containing individual and total nuclide or element concentrations, in 14 different units, may be generated as a function of time. Three classes of plot data may be produced by OPUS: (1) dominant or selected isotopes or elements, (2) photon and neutron source spectra, and (3) comparisons of selected quantities (totals or individual nuclides) between different ORIGEN-S cases. The input is designed for ease of use with self-explanatory parameter names, free-form input, and commonly used default values. The formatted output data produced by OPUS is designed to be used directly by the PlotOPUS graphics-plotting program. PlotOPUS is an interactive Visual Basic program designed for Windows 9x, 2000, and NT computers. PlotOPUS reads the formatted output data file produced by OPUS, plots the data, and will generate Windows metafile (WMF), JPEG bitmap (JPG), or Windows bitmap (BMP) files for saving the plot images. Even though it is designed to interface with PlotOPUS, the formatted OPUS output file can be easily read by other graphics packages for data visualization.

  14. Utilizing benchmark data from the ANL-ZPR diagnostic cores program

    International Nuclear Information System (INIS)

    The support of the criticality safety community is allowing the production of benchmark descriptions of several assemblies from the ZPR Diagnostic Cores Program. The assemblies have high sensitivities to nuclear data for a few isotopes. This can highlight limitations in nuclear data for selected nuclides or in standard methods used to treat these data. The present work extends the use of the simplified model of the U9 benchmark assembly beyond the validation of keff. Further simplifications have been made to produce a data testing benchmark in the style of the standard CSEWG benchmark specifications. Calculations for this data testing benchmark are compared to results obtained with more detailed models and methods to determine their biases. These biases or corrections factors can then be applied in the use of the less refined methods and models. Data testing results using Versions IV, V, and VI of the ENDF/B nuclear data are presented for keff, f28/f25, c28/f25, and βeff. These limited results demonstrate the importance of studying other integral parameters in addition to keff in trying to improve nuclear data and methods and the importance of accounting for methods and/or modeling biases when using data testing results to infer the quality of the nuclear data files

  15. Considerations in reviewing the waste volume reduction program in a large utility

    International Nuclear Information System (INIS)

    A program is underway at Ontario Hydro to establish a desirable future scheme for central processing/volume reduction of solid radioactive Low-Level Wastes (LLW) prior to their placement into the centralized storage, and in the future into a disposal facility. The approach being investigated is to furnish the current Waste Volume Reduction Facility (WVRF) with state-of-art processes, reclassify the waste categories and segregate the wastes such that each volume reduction (VR) process is then applied where it would be most effective. The ''optimized'' approach is then compared with other, specific schemes, which basically differ in that each scheme omits one of the major VR processes, thus allowing the next most effective process to take over its role. Each scheme is assessed quantitatively from the viewpoint of cost and VR effectiveness, and qualitatively from the viewpoint of resultant waste form. The economic assessments take into consideration the long term (20 year) impact of selected VR schemes on the overall waste management cost, including construction and operation of the storage facility. This paper highlights the overall study, includes the major results, and identifies aspects that need to be addressed in the selection of a desirable combination of VR processes in absence of knowledge of future waste disposal costs

  16. Utilizing job/task analysis to establish content validity in the design of training programs

    International Nuclear Information System (INIS)

    The decade of the 1980's has been a turbulent time for the Department of Energy. With concern mounting about the terrorist threat, a wave of congressional inquiries and internal inspections crossed the nation and engulfed many of the nuclear laboratories and facilities operated by DOE contractors. A typical finding was the need to improve, and increase, the training of the protective force. The immediate reaction resulted in a wide variety of responses, with most contractors feeling safer with too much, rather than not enough training. As soon as the initial pressures to upgrade subsided, a task force was established to evaluate the overall training needs. Representatives from the contractor facilities worked together to conduct a job analysis of the protective force. A generic task inventory was established, and validated at the different sites. This list has been invaluable for determining the tasks, conditions, and standards needed to develop well stated learning objectives. The enhanced training programs are being refined to ensure job content validity based on the data collected

  17. Defense by-products production and utilization program: noble metal recovery screening experiments

    International Nuclear Information System (INIS)

    Isotopes of the platinum metals (rutheium, rhodium, and palladium) are produced during uranium fuel fission in nuclear reactors. The strategic values of these noble metals warrant considering their recovery from spent fuel should the spent fuel be processed after reactor discharge. A program to evaluate methods for ruthenium, rhodium, and palladium recovery from spent fuel reprocessing liquids was conducted at Pacific Northwest Laboratory (PNL). The purpose of the work reported in this docuent was to evaluate several recovery processes revealed in the patent and technical literature. Beaker-scale screening tests were initiated for three potential recovery processes: precipitation during sugar denitration of nitric acid reprocessing solutions after plutonium-uranium solvent extraction, adsorption using nobe metal selective chelates on active carbon, and reduction forming solid noble metal deposits on an amine-borane reductive resin. Simulated reprocessing plant solutions representing typical nitric acid liquids from defense (PUREX) or commercial fuel reprocessing facilities were formulated and used for evaluation of the three processes. 9 refs., 3 figs., 9 tabs

  18. Optimizing antimicrobial therapy in critically ill patients

    OpenAIRE

    Pagani, Leonardo

    2014-01-01

    Virginie Vitrat,1 Serge Hautefeuille,2 Cécile Janssen,1 David Bougon,2 Michel Sirodot,2 Leonardo Pagani1,3 1Antimicrobial Stewardship Program, Infectious Diseases Unit, 2Intensive Care Unit, Annecy-Genevois Hospital Center (CHANGE), Annecy, France; 3Infectious Diseases Unit, Bolzano Central Hospital, Bolzano, Italy Abstract: Critically ill patients with infection in the intensive care unit (ICU) would certainly benefit from timely bacterial identification and effective antimicrobi...

  19. Optimizing antimicrobial therapy in critically ill patients

    OpenAIRE

    Vitrat V; Hautefeuille S; Janssen C; Bougon D; Sirodot M; Pagani L

    2014-01-01

    Virginie Vitrat,1 Serge Hautefeuille,2 Cécile Janssen,1 David Bougon,2 Michel Sirodot,2 Leonardo Pagani1,3 1Antimicrobial Stewardship Program, Infectious Diseases Unit, 2Intensive Care Unit, Annecy-Genevois Hospital Center (CHANGE), Annecy, France; 3Infectious Diseases Unit, Bolzano Central Hospital, Bolzano, Italy Abstract: Critically ill patients with infection in the intensive care unit (ICU) would certainly benefit from timely bacterial identification and effective antimicrobial t...

  20. Green power programs in Canada : 2003 : overview of Government green power policies, utility green power implementation initiatives, green power and certificate marketing programs, and their benefits

    International Nuclear Information System (INIS)

    Green power is defined as electricity produced from renewable sources, and whose production has low adverse impacts on the environment, human health and communities. Green power has near-zero greenhouse gas (GHG) emissions and includes sources such as wind, hydro, and solar power. It offers several environmental benefits, as well as the enhancement of energy security, regional development, economic diversification and the creation of skilled jobs. There are four categories of programs related to green power development in Canada: government green power policies, utility green power development programs, green power marketing initiatives, and green power certificate marketing initiatives. Most of the activities in Canada associated with these four categories in 2003 were discussed in this report. However, difficulties with quantification prevented the inclusion of some green power activities such as (1) the generation of green power not certified or identified by the generator as green power, (2) industry or residential self-generation, (3) net metering, and (4) small government programs. Green power generation facilities in 2003 totaled 775 MW of capacity compared to 539 MW in 2002. Hydro capacity represented 41 per cent, followed by wind capacity at 40 per cent and wood waste at 17 per cent. Most of the green power generation facilities in 2003 were located in Alberta, followed by British Columbia, Ontario and Quebec. 230 refs., 8 tabs., 1 fig

  1. A comparison of cognitive skills utilized in high school physical education, English, mathematics, and science programs

    Science.gov (United States)

    Schleyer, Claudia Janette

    The purpose of this study was two-fold. The first purpose was to identify cognitive skills and cognitive concepts perceived to be common among the high school physical education environment, and the science, math, and English classrooms. The second purpose was to identify various attitudes regarding physical education that influence the integration of the physical education curriculum with other academic subject areas, specifically, math, English, and science. Data for the study were accumulated over a six-month period using a survey instrument. Respondents included sixty-three teachers from fourteen different schools. The following findings were drawn from the analysis of data: (1) There is a significant difference (p $.05) among disciplines when teachers rank their attitudes regarding the value of physical education in the school; (4) there is no significant difference (p >.05) among disciplines when teachers rank their attitudes regarding the role of cognitive learning in physical education programs; and (5) there is no significant difference (p >$.05) among disciplines when teachers rank their attitudes regarding the integration of other academic disciplines in the school within the physical education curriculum. The following conclusions were made from the research findings: (1) English, math, and science share common cognitive skills; (2) physical education shares common cognitive concepts with math and science which provides a basis for linking these subjects together in the curriculum; (3) teachers in each of the four disciplines have a positive attitude toward the value of physical education; (4) teachers in each discipline possess a positive attitude toward the role of cognitive learning in physical education; and (5) teachers in each discipline have a positive attitude toward integration and a willingness to integrate physical education with the other subject areas.

  2. Discovering where the problem is hiding: Techniques from the formerly utilized sites remedial action program (FUSRAP)

    International Nuclear Information System (INIS)

    The identification of environmental problems resulting from past operations and practices at federal facilities is not only a good management practice but also a logical precursor to site wide cleanup. Current problems and associated data may date back fifty years, and relevant records and personnel familiar with old operations are difficult to locate. The principal sources for information pertaining to past practices is available in records holding areas at particular facilities and at the Federal Records Centers of the National Archives and Records Administration. The volume of Manhattan Engineer District (MED) and Atomic Energy Commission (AEC) records is on the order of 65 to 70 thousand cubic feet. The FUSRAP program reviewed documents in a systematic, ordered fashion. Reviews were focused on potential radiologic contamination of off-site facilities, and the effectiveness of this tailored procedure, necessitated by the volume of records, is well established. Sources of historical information in the public domain, such as libraries, assessor's offices and elsewhere also should be considered. The decision to use and pursue sources of information should be made by environmental managers rather than facility archivists or librarians. The manager must constantly weigh the potential records value and benefit against the expense of records search and collection. Likewise, environmental managers must realize that the records they collect, maintain and store are a vital legacy to future generations. Colleges and Universities also have an important role. Training in records management should be part of an environmental engineering curriculum, and partnerships/internships in reviewing records and implementing systems for the DOE should be pursued

  3. Polymeric Systems of Antimicrobial Peptides—Strategies and Potential Applications

    Directory of Open Access Journals (Sweden)

    Ewa Olędzka

    2013-11-01

    Full Text Available The past decade has seen growing interest in the investigation of peptides with antimicrobial activity (AMPs. One approach utilized in infection control is incorporation of antimicrobial agents conjugated with the polymers. This review presents the recent developments on polymeric AMP carriers and their potential applications in the biomedical and pharmaceutical fields.

  4. Maywood Interim Storage Site: Annual site environmental report, Maywood, New Jersey, Calendar year 1986: Formerly Utilized Sites Remedial Action Program

    International Nuclear Information System (INIS)

    During 1986, the environmental monitoring program was continued at the Maywood Interim Storage Site (MISS), a US Department of Energy (DOE) facility located in the Borough of Maywood and the Township of Rochelle Park, New Jersey. The MISS is presently used for the storage of low-level radioactively contaminated soils. The MISS is part of the Formerly Utilized Sites Remedial Action Program (FUSRAP). As part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Appropriations Act, remedial action and environmental monitoring programs are being conducted at this site and at vicinity properties by Bechtel National, Inc., Project Management Contractor for FUSRAP. The monitoring program at the MISS measures thoron and radon gas concentrations in air; external gamma radiation levels; and thorium, uranium, and radium concentrations in surface water, groundwater, and sediment. To verify that the site is in compliance with the DOE radiation protection standard (100 mrem/y) and to assess the potential effect on public health, the radiation dose was calculated for the maximally exposed individual. Based on the conservative scenario described in the report, the maximally exposed individual would receive an annual external exposure approximately equivalent to 1% of the DOE radiation protection standard of 100 mrem/y. This exposure is less than the exposure a person would receive during a round-trip flight from New York to Los Angeles (due to greater amounts of cosmic radiation at higher altitudes). The cumulative dose to the population within an 80-km (50-mi) radius of the MISS that would result from radioactive materials present at the site would be indistinguishable from the dose the same population would receive from naturally occurring radioactive sources. Results of the 1986 monitoring show that the MISS is in compliance with the DOE radiation protection standard. 16 refs., 8 figs., 15 tabs

  5. Establishment and utilization of radiological protection programs for the transport of radioactive material

    International Nuclear Information System (INIS)

    The present work has by objective to indicate rules for the establishment and the use of the Radiological Protection Programs (PPR) that are of application to the transport of radioactive materials according to that required by the Transport Regulation of the International Atomic Energy Agency (IAEA). The PPR are established and applied in systematic form for remittent, transport and addressees, to consider the measures of radiological protection and its appropriately control during the transport stages of radioactive material. In particular, in the work it is analyzed the PPR applied to the operative stage, in the one that can be considered as one of the more important documents to use since it summarizes the evaluations and the necessary controls of radiological protection. Also it is analyzed the importance that this document gets ready on the base that it converges in the the analyses, evaluations and data that have been kept in mind during the previous stages of design of bundles and production of packings, the types and quantities of involved bundles, as well as of considering the quantities of expeditions and its frequencies, the ways of transport, etc. It is included a brief description of the parts that the PPR conforms on the base of that suggested in the advanced draft of the TS-G-1.5 Guide 'Radiation Protection Programmes for Transport of Radioactive Material', of October, 2005, of the IAEA: objectives. necessity, scope, basic elements of a PPR in function of the occupational dose. assignment of functions and responsibilities for the establishment of a PPR, evaluation and dose optimization, surface contamination, segregation and other protection measures, responses in emergencies. training and administration systems for baled and transport of radioactive material. Next an example of PPR for the transport of bundles of the A Type by lorry with content of radiopharmaceuticals that are the bundles more used worldwide in the expeditions of radioactive

  6. First descriptions of blaKPC in Raoultella spp. (R. planticola and R. ornithinolytica): report from the SENTRY Antimicrobial Surveillance Program.

    Science.gov (United States)

    Castanheira, Mariana; Deshpande, Lalitagauri M; DiPersio, Joseph R; Kang, Julia; Weinstein, Melvin P; Jones, Ronald N

    2009-12-01

    Two strains of Raoultella planticola and one of Raoultella ornithinolytica showing carbapenem resistance were recovered from patients hospitalized in New Jersey and Ohio. All patients had received previous antimicrobial treatment, including carbapenems. These strains harbored bla(KPC-2) and bla(KPC-3). Carbapenemase genes were embedded in isoforms of Tn4401 and were plasmidic and chromosomal in location.

  7. Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains Isolated from Farm Animals from 1999 to 2002: Report from the Japanese Veterinary Antimicrobial Resistance Monitoring Program

    OpenAIRE

    Kojima, Akemi; Ishii, Yoshikazu; Ishihara, Kanako; Esaki, Hidetake; Asai, Tetsuo; Oda, Chitose; Tamura, Yutaka; Takahashi, Toshio; Yamaguchi, Keizo

    2005-01-01

    A nationwide surveillance for antimicrobial susceptibility in Escherichia coli strains isolated from food-producing animals in Japan was conducted from 1999 to 2002. Eighteen cefazolin-resistant E. coli strains were isolated from broilers. Six were CTX-M-type producing, and eight were CMY-2 producing, while eight had mutations at the ampC promoter region.

  8. Long-term impact of a chronic disease management program on hospital utilization and cost in an Australian population with heart disease or diabetes

    OpenAIRE

    Hamar, G Brent; Rula, Elizabeth Y.; Coberley, Carter; Pope, James E.; Larkin, Shaun

    2015-01-01

    Background To evaluate the longitudinal value of a chronic disease management program, My Health Guardian (MHG), in reducing hospital utilization and costs over 4 years. Methods The MHG program provides individualized support via telephonic nurse outreach and online tools for self-management, behavior change and well-being. In follow up to an initial 18-month analysis of MHG, the current study evaluated program impact over 4 years. A matched-cohort analysis retrospectively compared MHG partic...

  9. Utilization and spending trends for antiretroviral medications in the U.S. Medicaid program from 1991 to 2005

    Directory of Open Access Journals (Sweden)

    Li Xing

    2007-10-01

    Full Text Available Abstract Background HIV/AIDS incidence and mortality rates have decreased in the U.S. since 1996. Accompanying the longer life spans of those diagnosed with the disease, however, is a tremendous rise in expenditures on medication. The objective of this study is to describe the trends in utilization of, spending on, and market shares of antiretroviral medications in the U.S. Medicaid Program. Antiretroviral drugs include nucleoside reverse transcriptase inhibitors (NRTIs, protease inhibitors (PIs, nonnucleoside reverse transcriptase inhibitors (NNRTIs, and fusion inhibitors (FIs. Methods Utilization and payment data from 1991 to 2005 are provided by the Centers for Medicare & Medicaid Services. Descriptive summary analyses were used to assess quarterly prescription numbers and amounts of payment. Results The total number of prescriptions for antiretrovirals increased from 168,914 in 1991 to 2.0 million in 1998, and 3.0 million in 2005, a 16.7-fold increase over 15 years. The number of prescriptions for NRTIs reached 1.6 million in 2005. Prescriptions for PIs increased from 114 in 1995 to 932,176 in 2005, while the number of prescriptions for NNRTIs increased from 1,339 in 1996 to 401,272 in 2005. The total payment for antiretroviral drugs in the U.S. Medicaid Program increased from US$ 30.6 million in 1991 to US$ 1.6 billion in 2005, a 49.8-fold increase. In 2005, NRTIs as a class had the highest payment market share. These drugs alone accounted for US$ 787.9 million in Medicaid spending (50.8 percent of spending on antiretrovirals. Payment per prescription for each drug, with the exception of Agenerase®, increased, at least somewhat, over time. The relatively expensive drugs in 2005 included Trizivir® ($1040 and Combivir® ($640, as well as Reyataz® ($750, Lexiva® ($700, Sustiva® ($420, Viramune® ($370, and Fuzeon® ($1914. Conclusion The tremendous growth in antiretroviral spending is due primarily to rising utilization, secondarily to

  10. Vicinity Property Assessments at Formerly Utilized Sites Remedial Action Program Project Sites in the New York District - 13420

    International Nuclear Information System (INIS)

    The Formerly Utilized Sites Remedial Action Program (FUSRAP) has addressed sites across the nation for almost 4 decades. Multiple stake holder pressures, multiple regulations, and process changes occur over such long time periods. These result in many challenges to the FUSRAP project teams. Initial FUSRAP work was not performed under Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) Records of Decision (ROD). The ROD identifies the remedy decision and ultimately the criteria to be used to release a site. Early FUSRAP projects used DOE Orders or the Uranium Mill Tailings Radiation Control Act (UMTRCA) standards. Under current RODs, regulations may differ, resulting in different cleanup criteria than that used in prior Vicinity Property (VP) remediation. The USACE, in preparation for closeout of Sites, conducts reviews to evaluate whether prior actions were sufficient to meet the cleanup criteria specified in the current ROD. On the basis of these reviews, USACE has conducted additional sampling, determined that prior actions were sufficient, or conducted additional remediation consistent with the selected remedy in the ROD. As the public pressures, regulations, and processes that the FUSRAP encounters continue to change, the program itself continues to evolve. Assessment of VPs at FUSRAP sites is a necessary step in the life cycle of our site management. (authors)

  11. Prospect of the QTL-qSB-9Tq utilized in molecular breeding program of japonica rice against sheath blight

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The major QTL-qSB-9Tq conferring partial resistance to rice (Oryza sativa L.) sheath blight (Rhizoctonia solani Kühn) has been verified on chromosome 9 of the indica rice cultivar, Teqing. In this study, the prospect of this QTL utilized in molecular breeding program of japonica rice for sheath blight resistance was investigated. Most of the japonica rice cultivars showed lower level of sheath blight resistance than the indica rice cultivars. At the corresponding site of qSB-9Tq, nine typical japonica rice culfivars from different ecological regions or countries proved to possess the susceptible allele(s). Introgression of qSB-9Tq into these cultivars enhanced their resistance level by decreasing sheath blight score of 1.0 (0.5-1.3), which indicated that qSB-9Tq had a large potential in strengthening the resistance of japonica rice to sheath blight. The use of the three molecular markers, which were polymorphic between Teqing and many japonica rice cultivars, promotes the application of qSB-9Tq in a concrete molecular breeding program.

  12. Environmental audit of the Maywood Site: Formerly Utilized Sites Remedial Action Program, Maywood Interim Storage Site vicinity properties

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-01

    This report presents the results of the Environmental Audit of the Maywood Site managed by the Formerly Utilized Sites Remedial Action Program (FUSRAP). The Audit was carried out from November 7 through 16, 1990. The Audit Team found overall technical competence and knowledge of management and staff to be excellent. This applies to DOE as well as to Bechtel National, Incorporated (BNI). In particular, there was excellent knowledge of federal, state, and local environmental regulations, as well as analysis for applicability of these regulations to FUSRAP. Project management of the Maywood Site is also excellent. BNI and DOE project staff have made frequent contact with members of the community, and all removal actions and remedial investigation activities have been planned, scheduled, and accomplished with competence and attention to total quality principles. To date, all actions taken for the Maywood Site cleanup have been completed ahead of schedule and on or under budget. Weakness noted include self-assessment efforts by DOE, failure to fully implement DOE Order requirements throughout the program, and some discrepancies in formally documenting and reviewing procedures. 7 figs., 10 tabs.

  13. An Assessment Model for Energy Efficiency Program Planning in Electric Utilities: Case of the Pacific of Northwest U.S.A

    Science.gov (United States)

    Iskin, Ibrahim

    Energy efficiency stands out with its potential to address a number of challenges that today's electric utilities face, including increasing and changing electricity demand, shrinking operating capacity, and decreasing system reliability and flexibility. Being the least cost and least risky alternative, the share of energy efficiency programs in utilities' energy portfolios has been on the rise since the 1980s, and their increasing importance is expected to continue in the future. Despite holding great promise, the ability to determine and invest in only the most promising program alternatives plays a key role in the successful use of energy efficiency as a utility-wide resource. This issue becomes even more significant considering the availability of a vast number of potential energy efficiency programs, the rapidly changing business environment, and the existence of multiple stakeholders. This dissertation introduces hierarchical decision modeling as the framework for energy efficiency program planning in electric utilities. The model focuses on the assessment of emerging energy efficiency programs and proposes to bridge the gap between technology screening and cost/benefit evaluation practices. This approach is expected to identify emerging technology alternatives which have the highest potential to pass cost/benefit ratio testing procedures and contribute to the effectiveness of decision practices in energy efficiency program planning. The model also incorporates rank order analysis and sensitivity analysis for testing the robustness of results from different stakeholder perspectives and future uncertainties in an attempt to enable more informed decision-making practices. The model was applied to the case of 13 high priority emerging energy efficiency program alternatives identified in the Pacific Northwest, U.S.A. The results of this study reveal that energy savings potential is the most important program management consideration in selecting emerging energy

  14. A case study review of technical and technology issues for transition of a utility load management program to provide system reliability resources in restructured electricity markets

    Energy Technology Data Exchange (ETDEWEB)

    Weller, G.H.

    2001-07-15

    Utility load management programs--including direct load control and interruptible load programs--were employed by utilities in the past as system reliability resources. With electricity industry restructuring, the context for these programs has changed; the market that was once controlled by vertically integrated utilities has become competitive, raising the question: can existing load management programs be modified so that they can effectively participate in competitive energy markets? In the short run, modified and/or improved operation of load management programs may be the most effective form of demand-side response available to the electricity system today. However, in light of recent technological advances in metering, communication, and load control, utility load management programs must be carefully reviewed in order to determine appropriate investments to support this transition. This report investigates the feasibility of and options for modifying an existing utility load management system so that it might provide reliability services (i.e. ancillary services) in the competitive markets that have resulted from electricity industry restructuring. The report is a case study of Southern California Edison's (SCE) load management programs. SCE was chosen because it operates one of the largest load management programs in the country and it operates them within a competitive wholesale electricity market. The report describes a wide range of existing and soon-to-be-available communication, control, and metering technologies that could be used to facilitate the evolution of SCE's load management programs and systems to provision of reliability services. The fundamental finding of this report is that, with modifications, SCE's load management infrastructure could be transitioned to provide critical ancillary services in competitive electricity markets, employing currently or soon-to-be available load control technologies.

  15. Hospital-wide rollout of antimicrobial stewardship: a stepped-wedge randomized trial.

    Science.gov (United States)

    Palmay, Lesley; Elligsen, Marion; Walker, Sandra A N; Pinto, Ruxandra; Walker, Scott; Einarson, Thomas; Simor, Andrew; Rachlis, Anita; Mubareka, Samira; Daneman, Nick

    2014-09-15

    Our objective was to rigorously evaluate the impact of an antimicrobial stewardship audit-and-feedback intervention, via a stepped-wedge randomized trial. An effective intensive care unit (ICU) audit-and-feedback program was rolled out to 6 non-ICU services in a randomized sequence. The primary outcome was targeted antimicrobial utilization, using a negative binomial regression model to assess the impact of the intervention while accounting for secular and seasonal trends. The intervention was successfully transitioned, with high volumes of orders reviewed, suggestions made, and recommendations accepted. Among patients meeting stewardship review criteria, the intervention was associated with a large reduction in targeted antimicrobial utilization (-21%, P = .004); however, there was no significant change in targeted antibiotic use among all admitted patients (-1.2%, P = .9), and no reductions in overall costs and microbiologic outcomes. An ICU day 3 audit-and-feedback program can be successfully expanded hospital-wide, but broader benefits on non-ICU wards may require interventions earlier in the course of treatment.

  16. Hospital-wide rollout of antimicrobial stewardship: a stepped-wedge randomized trial.

    Science.gov (United States)

    Palmay, Lesley; Elligsen, Marion; Walker, Sandra A N; Pinto, Ruxandra; Walker, Scott; Einarson, Thomas; Simor, Andrew; Rachlis, Anita; Mubareka, Samira; Daneman, Nick

    2014-09-15

    Our objective was to rigorously evaluate the impact of an antimicrobial stewardship audit-and-feedback intervention, via a stepped-wedge randomized trial. An effective intensive care unit (ICU) audit-and-feedback program was rolled out to 6 non-ICU services in a randomized sequence. The primary outcome was targeted antimicrobial utilization, using a negative binomial regression model to assess the impact of the intervention while accounting for secular and seasonal trends. The intervention was successfully transitioned, with high volumes of orders reviewed, suggestions made, and recommendations accepted. Among patients meeting stewardship review criteria, the intervention was associated with a large reduction in targeted antimicrobial utilization (-21%, P = .004); however, there was no significant change in targeted antibiotic use among all admitted patients (-1.2%, P = .9), and no reductions in overall costs and microbiologic outcomes. An ICU day 3 audit-and-feedback program can be successfully expanded hospital-wide, but broader benefits on non-ICU wards may require interventions earlier in the course of treatment. PMID:24928294

  17. Optimizing antimicrobial therapy in critically ill patients.

    Science.gov (United States)

    Vitrat, Virginie; Hautefeuille, Serge; Janssen, Cécile; Bougon, David; Sirodot, Michel; Pagani, Leonardo

    2014-01-01

    Critically ill patients with infection in the intensive care unit (ICU) would certainly benefit from timely bacterial identification and effective antimicrobial treatment. Diagnostic techniques have clearly improved in the last years and allow earlier identification of bacterial strains in some cases, but these techniques are still quite expensive and not readily available in all institutions. Moreover, the ever increasing rates of resistance to antimicrobials, especially in Gram-negative pathogens, are threatening the outcome for such patients because of the lack of effective medical treatment; ICU physicians are therefore resorting to combination therapies to overcome resistance, with the direct consequence of promoting further resistance. A more appropriate use of available antimicrobials in the ICU should be pursued, and adjustments in doses and dosing through pharmacokinetics and pharmacodynamics have recently shown promising results in improving outcomes and reducing antimicrobial resistance. The aim of multidisciplinary antimicrobial stewardship programs is to improve antimicrobial prescription, and in this review we analyze the available experiences of such programs carried out in ICUs, with emphasis on results, challenges, and pitfalls. Any effective intervention aimed at improving antibiotic usage in ICUs must be brought about at the present time; otherwise, we will face the challenge of intractable infections in critically ill patients in the near future. PMID:25349478

  18. Antimicrobial commodities. part 2. Antimicrobial and odor-preventing fibers; Kokin seikatsu yohin ( 2 ). Kokin boshu sen`i

    Energy Technology Data Exchange (ETDEWEB)

    Yabe, N. [Toray Research Center Inc., Shiga (Japan)

    1998-05-01

    Demand for antimicrobial and order-preventing fibers is still expanding smoothly after a boom during a period from 1982 to 1985 owing to the great progress in its safety, manufacturing technology and evaluation of antimicrobial property. In this paper, the antimicrobial and odor-preventing fibers are described summarily. Main antimicrobial agents used in the antimicrobial and odor-preventing fibers hitherto are aromatic halogen compounds and organic silicon quaternary ammonium salts. In recent years, the kinds of antimicrobial agents are increased corresponding to the expansion of the demand for antimicrobial and odor-preventing fibers. Specifically, metals or inorganic particles containing metals; and quaternary ammonium salts or organic silicon quaternary ammonium salts are used frequently. Recently, the studies in respect to the utilization of chitin and chitosan are executed actively. Mainly employed processing method of the antimicrobial and odor-prevention fibers is a post processing by a working liquid containing kneaded fiber forming (mixed fiber forming) of antimicrobial inorganic particles such as metal powders or metal supporting zeolites; and an antimicrobial agent. 8 refs., 3 figs., 5 tabs.

  19. Antimicrobial resistance in Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and group A beta-haemolytic streptococci in 2002-2003. Results of the multinational GRASP Surveillance Program

    DEFF Research Database (Denmark)

    Beekmann, Susan E; Heilmann, Kris P; Richter, Sandra S;

    2005-01-01

    A multinational surveillance study, GRASP, was conducted between November 2002 and April 2003 with the aim of assessing rates of antimicrobial resistance among 2656 isolates of Streptococcus pneumoniae, 2486 isolates of group A beta-haemolytic streptococci, 1358 isolates of Haemophilus influenzae...... and 1047 of Moraxella catarrhalis from 20 countries in Europe, eastern Asia and southern Africa. Conspicuous differences between various countries were noted in the S. pneumoniae resistance rates observed for penicillin (0-79.2%) and erythromycin (4-66%), along with other antimicrobials. The percentage...... of MDR strains was above 25% in 8 of the 20 countries studied. Group A streptococcal macrolide resistance rates ranged from 0% to 35% by country, while rates of beta-lactamase production ranged from 0% to 39% for H. influenzae and 80-100% for M. catarrhalis. Antibiotic resistance in S. pneumoniae remains...

  20. Beyond the Price Effect in Time-of-Use Programs: Results from a Municipal Utility Pilot, 2007-2008

    Energy Technology Data Exchange (ETDEWEB)

    Lutzenhiser, Susan; Peters, Jane; Moezzi, Mithra; Woods, James

    2009-08-12

    This paper discusses results of a two-year collaborative research project between the authors and the Demand Response Research Center focused on behavioral response to a voluntary time-of-use pilot rate offered by the Sacramento Municipal Utilities District (SMUD) under the PowerChoice label. The project had two purposes: one was to assess the potential for increasing demand response through the introduction of enhanced information and real-time consumption feedback; the second was to better understand behavioral response to a TOU rate. Three successive waves of telephone surveys collected details about reasons for participation, actions taken, capacities and constraints to altering behavior, and a range of salient conditions, such as demographics and dwelling characteristics. Pre- and post-program interval meter data for participants and a comparison sample of households were also collected and analyzed to consider initial and season-change price effects of the rate and the effect of supplemental information treatments on response. Over half of surveyed participating households reported that they had made a great deal of effort to adjust their electricity consumption to the rate. Despite this, load data analysis revealed only minimal price effects; and, though households subjected to information treatments seemed to have learned from these treatments, load data analysis again detected only minimal effects on load. Given the currently high hopes for behavioral intervention and residential TOU rates, these unexpected results require explanation. We suggest a number of possibilities and discuss some implications for TOU programs, and for understanding demand response behavior and approaches to experiments with TOU rates.

  1. Engaging hospitalists in antimicrobial stewardship: Lessons from a multihospital collaborative.

    Science.gov (United States)

    Mack, Megan R; Rohde, Jeffrey M; Jacobsen, Diane; Barron, James R; Ko, Christin; Goonewardene, Michael; Rosenberg, David J; Srinivasan, Arjun; Flanders, Scott A

    2016-08-01

    Inappropriate antimicrobial use in hospitalized patients contributes to antimicrobial-resistant infections and complications. We sought to evaluate the impact, barriers, and facilitators of antimicrobial stewardship best practices in a diverse group of hospital medicine programs. This multihospital initiative included 1 community nonteaching hospital, 2 community teaching hospitals, and 2 academic medical centers participating in a collaborative with the Centers for Disease Control and Prevention and the Institute for Healthcare Improvement. We conducted multimodal physician education on best practices for antimicrobial use including: (1) enhanced antimicrobial documentation, (2) improved quality and accessibility of local clinical guidelines, and (3) a 72-hour antimicrobial "timeout." Implementation barriers included variability in physician practice styles, lack of awareness of stewardship importance, and overly broad interventions. Facilitators included engaging hospitalists, collecting real time data and providing performance feedback, and appropriately limiting the scope of interventions. In 2 hospitals, complete antimicrobial documentation in sampled medical records improved significantly (4% to 51% and 8% to 65%, P < 0.001 for each comparison). A total of 726 antimicrobial timeouts occurred at 4 hospitals, and 30% resulted in optimization or discontinuation of antimicrobials. With careful attention to key barriers and facilitators, hospitalists can successfully implement effective antimicrobial stewardship practices. Journal of Hospital Medicine 2016;11:576-580. © 2016 Society of Hospital Medicine. PMID:27130473

  2. Antimicrobial stewardship in small animal veterinary practice: from theory to practice.

    Science.gov (United States)

    Guardabassi, Luca; Prescott, John F

    2015-03-01

    Despite the increasing recognition of the critical role for antimicrobial stewardship in preventing the spread of multidrug-resistant bacteria, examples of effective antimicrobial stewardship programs are rare in small animal veterinary practice. This article highlights the basic requirements for establishing stewardship programs at the clinic level. The authors provide suggestions and approaches to overcome constraints and to move from theoretic concepts toward implementation of effective antimicrobial stewardship programs in small animal clinics.

  3. Risk factors in the management of antimicrobial agents in nursing

    Directory of Open Access Journals (Sweden)

    Regina Consolação dos Santos

    2016-06-01

    Full Text Available Current retrospective, descriptive, document-based study identified the risk factors in the administration of antimicrobial drugs by the nursing team. The hospital records at the Hematology and Oncology clinics of patients treated with antimicrobial agents in a hospital in the center-western region of the state of Minas Gerais, Brazil, between January 2008 and December 2011, were analyzed. Data were investigated with IBM program, Statistical Package of Social Sciences (SPSS 21.0 and inferential statistics. Chi-square and Fisher´s exact tests were employed to assess the differences between the categorical variables. Risk factors related to the administration of antimicrobial agents by the nursing team comprised lack of records of phlogistic infection signs; inadequate schedules for the administration of antimicrobial drugs; lack of precaution and isolation measures and of swab sampling. Continuous education programs for nurses, focusing on safe administration of antimicrobial agents, are highly relevant.

  4. Antimicrobial Peptides in 2014

    Directory of Open Access Journals (Sweden)

    Guangshun Wang

    2015-03-01

    Full Text Available This article highlights new members, novel mechanisms of action, new functions, and interesting applications of antimicrobial peptides reported in 2014. As of December 2014, over 100 new peptides were registered into the Antimicrobial Peptide Database, increasing the total number of entries to 2493. Unique antimicrobial peptides have been identified from marine bacteria, fungi, and plants. Environmental conditions clearly influence peptide activity or function. Human α-defensin HD-6 is only antimicrobial under reduced conditions. The pH-dependent oligomerization of human cathelicidin LL-37 is linked to double-stranded RNA delivery to endosomes, where the acidic pH triggers the dissociation of the peptide aggregate to release its cargo. Proline-rich peptides, previously known to bind to heat shock proteins, are shown to inhibit protein synthesis. A model antimicrobial peptide is demonstrated to have multiple hits on bacteria, including surface protein delocalization. While cell surface modification to decrease cationic peptide binding is a recognized resistance mechanism for pathogenic bacteria, it is also used as a survival strategy for commensal bacteria. The year 2014 also witnessed continued efforts in exploiting potential applications of antimicrobial peptides. We highlight 3D structure-based design of peptide antimicrobials and vaccines, surface coating, delivery systems, and microbial detection devices involving antimicrobial peptides. The 2014 results also support that combination therapy is preferred over monotherapy in treating biofilms.

  5. Descriptors for antimicrobial peptides

    DEFF Research Database (Denmark)

    Jenssen, Håvard

    2011-01-01

    Introduction: A frightening increase in the number of isolated multidrug resistant bacterial strains linked to the decline in novel antimicrobial drugs entering the market is a great cause for concern. Cationic antimicrobial peptides (AMPs) have lately been introduced as a potential new class of ...

  6. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... Translation - Animation of Antimicrobial Resistance (WMV - 19.2MB) Chinese Translation - Animation of Antimicrobial Resistance (WMV - 19.2MB) ... FEAR Act Site Map Transparency Website Policies U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver ...

  7. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... use of antimicrobial drugs will result in the development of resistant strains of bacteria, complicating clinician's efforts to select the appropriate antimicrobial for treatment. Accordingly, efforts are underway in both veterinary and human medicine to preserve the effectiveness of these drugs. ...

  8. Evaluation of the program 'Environmentally correct utilization of ashes'; Utvaerdering av programmet 'Miljoeriktig anvaendning av askor'

    Energy Technology Data Exchange (ETDEWEB)

    Herbert, Roger B. (Uppsala Univ., Inst. of Earth Sciences, Uppsala (Sweden))

    2008-04-15

    Vaermeforsk's program Environmentally-correct utilization of ashes ('Ash program') has financed research and development projects since 2002. The overall goal of the program is that knowledge and data for decision-making shall exist so that 90 percent of Swedish ash from energy production is utilized in an environmentally-correct application by the end of 2008. In this report, an evaluation of the Ash program is presented, with an overall goal of determining if the program is proceeding along the correct path to goal fulfillment. The following components of the program have been evaluated: Funded projects during the program period 2002-2008, with focus on project selection, goal fulfillment, and the need for addition studies; Selected projects that have particular significance for goal fulfillment; Communication and dissemination of results; Significance of the Ash program's network. Funded projects within each research area have been reviewed with respect to project prioritization and the relevance of projects for goal fulfillment. The projects have been compared with previously identified research and development needs. The primary emphasis in the areas of Engineering and Landfills lies in projects that, taken together, can lead to an increased confidence in our understanding of the geotechnical and environmental properties of ash. In the area Forest and soil, Vaermeforsk has funded new ash recycling and fertilization experiments and also continuation projects. Such a prioritization is warranted, since long-term experiments are necessary in order to indicate if the addition of ash has an effect. Large ventures within the areas of Engineering, Landfills and Forests arouse the greatest attention; these are the projects that will presumably make the greatest breakthroughs for ash utilization. It is my assessment that the Ash program is proceeding along the correct path toward goal fulfillment, and that the program has contributed to knowledge and

  9. Alternative Antimicrobial Approach: Nano-Antimicrobial Materials

    Directory of Open Access Journals (Sweden)

    Nurit Beyth

    2015-01-01

    Full Text Available Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

  10. Overview of the energy research and development program of the Federal Republic of Germany with special attention to coal utilization technology

    Energy Technology Data Exchange (ETDEWEB)

    Holighaus, R.

    1980-01-01

    The objectives, the content and the finding of the Energy Research and Development Program are outlined with special attention to coal utilization technology. The largest part of the program is borne by the Federal Ministry for Research and Technology. The distribution of pending program shows clearly the priority for 'Coal and other fossil sources' which in fact means coal, the only large domestic energy source. The development activities are divided into following sections (in the order of financial priority): electricity generation from coal, gas generation from coal, liquefaction of coal, coal production and direct combustion. The different development strategies which are applied in the individual fields of coal utilization are discussed in detail. Several newly developed technologies are now, or in the near future, ready for commercial application. From the developments the Federal Government also expects to increase the attractivity of German industries as partners of joint ventures with countries having large coal deposits.

  11. Cost-Utility Analysis of Three U.S. HIV Linkage and Re-engagement in Care Programs from Positive Charge.

    Science.gov (United States)

    Jain, Kriti M; Zulliger, Rose; Maulsby, Cathy; Kim, Jeeyon Janet; Charles, Vignetta; Riordan, Maura; Holtgrave, David

    2016-05-01

    Linking and retaining people living with HIV in ongoing, HIV medical care is vital for ending the U.S. HIV epidemic. Yet, 41-44 % of HIV+ individuals are out of care. In response, AIDS United initiated Positive Charge, a series of five HIV linkage and re-engagement projects around the U.S. This paper investigates whether three Positive Charge programs were cost effective and calculates a return on investment for each program. It uses standard methods of cost utility analysis and WHO-CHOICE thresholds. All three projects were found to be cost effective, and two were highly cost effective. Cost utility ratios ranged from $4439 to $137,271. These results suggest that HIV linkage to care programs are a productive and efficient use of public health funds. PMID:26563760

  12. Cost-Utility Analysis of Three U.S. HIV Linkage and Re-engagement in Care Programs from Positive Charge.

    Science.gov (United States)

    Jain, Kriti M; Zulliger, Rose; Maulsby, Cathy; Kim, Jeeyon Janet; Charles, Vignetta; Riordan, Maura; Holtgrave, David

    2016-05-01

    Linking and retaining people living with HIV in ongoing, HIV medical care is vital for ending the U.S. HIV epidemic. Yet, 41-44 % of HIV+ individuals are out of care. In response, AIDS United initiated Positive Charge, a series of five HIV linkage and re-engagement projects around the U.S. This paper investigates whether three Positive Charge programs were cost effective and calculates a return on investment for each program. It uses standard methods of cost utility analysis and WHO-CHOICE thresholds. All three projects were found to be cost effective, and two were highly cost effective. Cost utility ratios ranged from $4439 to $137,271. These results suggest that HIV linkage to care programs are a productive and efficient use of public health funds.

  13. Evaluation and demonstration of methods for improved fuel utilization. Fort Calhoun Poolside Inspection Programs: end-of-cycles 4 and 5

    Energy Technology Data Exchange (ETDEWEB)

    LaVake, J.C.; Smith, G.P.

    1980-08-01

    The purpose of this program is to demonstrate two techniques for improving fuel utilization in current Pressurized Water Reactors (PWR): (1) more efficient fuel management, and (2) high burnup. These improvements are being demonstrated in the Fort Calhoun reactor, a 1420 Mwt PWR. A more efficient fuel management scheme called SAVFUEL (Shimmed And Very Flexible Uranium Element Loading), will be demonstrated which reduces neutron leakage and is expected to reduce uranium requirements. Another part of the demonstration program will increase the fuel burnup of the current 14 x 14 fuel design to further reduce uranium requirements. The program is a joint Department of Energy (DOE), Omaha Public Power District (OPPD) and Combustion Engineering (C-E) endeavor and is part of a national effort to improve uranium utilization in light water reactors.

  14. Evaluation and demonstration of methods for improved fuel utilization. Fort Calhoun Poolside Inspection Programs: end-of-cycles 4 and 5

    International Nuclear Information System (INIS)

    The purpose of this program is to demonstrate two techniques for improving fuel utilization in current Pressurized Water Reactors (PWR): (1) more efficient fuel management, and (2) high burnup. These improvements are being demonstrated in the Fort Calhoun reactor, a 1420 Mwt PWR. A more efficient fuel management scheme called SAVFUEL (Shimmed And Very Flexible Uranium Element Loading), will be demonstrated which reduces neutron leakage and is expected to reduce uranium requirements. Another part of the demonstration program will increase the fuel burnup of the current 14 x 14 fuel design to further reduce uranium requirements. The program is a joint Department of Energy (DOE), Omaha Public Power District (OPPD) and Combustion Engineering (C-E) endeavor and is part of a national effort to improve uranium utilization in light water reactors

  15. Treatment Modalities and Antimicrobial Stewardship Initiatives in the Management of Intra-Abdominal Infections

    Directory of Open Access Journals (Sweden)

    Charles Hoffmann

    2016-02-01

    Full Text Available Antimicrobial stewardship programs (ASPs focus on improving the utilization of broad spectrum antibiotics to decrease the incidence of multidrug-resistant Gram positive and Gram negative pathogens. Hospital admission for both medical and surgical intra-abdominal infections (IAIs commonly results in the empiric use of broad spectrum antibiotics such as fluoroquinolones, beta-lactam beta-lactamase inhibitors, and carbapenems that can select for resistant organisms. This review will discuss the management of uncomplicated and complicated IAIs as well as highlight stewardship initiatives focusing on the proper use of broad spectrum antibiotics.

  16. NRC review of Electric Power Research Institute's Advanced Light Reactor Utility Requirements Document - Program summary, Project No. 669

    Energy Technology Data Exchange (ETDEWEB)

    1992-08-01

    The staff of the US Nuclear Regulatory Commission has prepared Volume 1 of a safety evaluation report (SER), NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document -- Program Summary,'' to document the results of its review of the Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document.'' This SER provides a discussion of the overall purpose and scope of the Requirements Document, the background of the staff's review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  17. UMCP-BG and E collaboration in nuclear power engineering in the framework of DOE-Utility Nuclear Power Engineering Education Matching Grant Program

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, Lothar PhD

    2000-03-01

    The DOE-Utility Nuclear Power Engineering Education Matching Grant Program has been established to support the education of students in Nuclear Engineering Programs to maintain a knowledgeable workforce in the United States in order to keep nuclear power as a viable component in a mix of energy sources for the country. The involvement of the utility industry ensures that this grant program satisfies the needs and requirements of local nuclear energy producers and at the same time establishes a strong linkage between education and day-to-day nuclear power generation. As of 1997, seventeen pairs of university-utility partners existed. UMCP was never a member of that group of universities, but applied for the first time with a proposal to Baltimore Gas and Electric Company in January 1999 [1]. This proposal was generously granted by BG&E [2,3] in the form of a gift in the amount of $25,000 from BG&E's Corporate Contribution Program. Upon the arrival of a newly appointed Director of Administration in the Department of Materials and Nuclear Engineering, the BG&E check was deposited into the University's Maryland Foundation Fund. The receipt of the letter and the check enabled UMCP to apply for DOE's matching funds in the same amount by a proposal.

  18. Ⅰ类切口预防性抗菌药物使用率的调查分析%Investigation and Analysis of Preventability Antimicrobial Drugs Utilization Ratio of Type I Incision

    Institute of Scientific and Technical Information of China (English)

    徐少银; 顾新; 张海霞; 孙蓉蓉

    2016-01-01

    Objective To analyze the reasons of antimicrobial drugs high prevention usage rate in Ⅰ incision surgery perioperative. Methods A general survey of type Ⅰ incision surgery perioperative preventive medications was taken in a grade 3 and first-class hospital in a quarter of 2014 and compared with the overall situation, and use of quality management tools to analyze possible cause of the prophylactic usage rate on the high side. Results In the past three years, the type Ⅰ incision operation preventive antimicrobial rate from 80.56% decreased to 48.53%, do not meet the indicators prescribed by the health planning commission. Research data show that antimicrobial drugs in principle usage rate is higher (47.55%), do not need to use 9.28% of the diseases is not rational drug use behavior. Drugs, the lack of professional knowledge, the lack of training, the index set of component ratio is high and no difference, disease prevention regulation does not reach the designated position, etc were the reasons for hospital type Ⅰ incision preventive antimicrobial agents usage. Conclusion Hospital should strengthen the knowledge training and examination for perioperative antimicrobial drugs for type Ⅰ incision; Combined with antibacterial drug monitoring and control system, strengthen the guidance of clinical pharmacists function; Recommend the health administrative department to differentiate setting parameter values of type Ⅰ incision prophylaxis.%目的 分析Ⅰ类切口手术围术期抗菌药物预防使用率偏高的原因.方法 通过普查某三甲医院2014 年某一季度Ⅰ类切口手术围术期预防用药情况,与医院 Ⅰ 类切口抗菌药物预防用药总体情况进行对比,同时利用质量管理工具分析导致预防用药率偏高的可能原因.结果 抗菌药物专项整治三年间,Ⅰ 类切口手术预防性抗菌药物比率由 80.56%降为 48.53%,未达到卫计委规定的指标.研究数据中原则上需要预防用

  19. Stimulating utilities to promote energy efficiency: Process evaluation of Madison Gas and Electric's Competition Pilot Program

    Energy Technology Data Exchange (ETDEWEB)

    Vine, E.; De Buen, O.; Goldfman, C.

    1990-12-01

    This report describes the process evaluation of the design and implementation of the Energy Conservation Competition Pilot (hereafter referred to as the Competition), ordered by the Public Service Commission of Wisconsin (PSCW) with a conceptual framework defined by PSCW staff for the Madison Gas and Electric (MGE) Company. This process evaluation documents the history of the Competition, describing the marketing strategies adopted by MGE and its competitors, customer service and satisfaction, administrative issues, the distribution of installed measures, free riders, and the impact of the Competition on MGE, its competitors, and other Wisconsin utilities. We also suggest recommendations for a future Competition, compare the Competition with other approaches that public utility commissions (PUCs) have used to motivate utilities to promote energy efficiency, and discuss its transferability to other utilities. 48 refs., 8 figs., 40 tabs.

  20. Utilization of research and training reactors in the study program of students at Slovak University of Technology

    International Nuclear Information System (INIS)

    Full text: Preparation of operating staff for nuclear industry is and also has to be one of the most serious education processes mainly in the Central-European countries like Slovakia, Hungary or Czech Republic, where about 40-50 % of electricity is produced in nuclear power plants (NPP). A possible impact of operator failure on safe an economically effective operation of NPP is very high. Despite the fact that the automation in NPP-control made a huge progress, the human activity on all levels of operation is the determining factor for safe and reliable operation of NPP. High level of the operating staff education is determined by: the expertise of the teachers, the motivation of the students; the practical exercises, the material conditions (textbooks, models, simulation programs), effectiveness of education and training process (realistic time table, linkage of knowledge etc.) and the high level of basic education, good relation to mathematics, physics, computers, technical orientation, theoretical knowledge and skills. Technical universities like Slovak University of Technology (STU) in Bratislava take responsibility for the level of technical education of graduates. Excellent students can surely find jobs in nuclear industry, but for the operating staff it is recommended to study Power Plant Engineering and Power electronics. There is a possibility (beside the obligatory subjects) to choose a batch of 12 optional subjects focused on peaceful use of nuclear energy. In general, there exists a very extensive and also effective international collaboration in nuclear industry. Similarly good situation is also on the level of universities and technical high schools. STU Bratislava established contacts with many universities abroad. Thanks to the support from Slovenske elektrarne Plc., student graduates in nuclear power engineering specialisation have had (hopefully will have also in the future) possibilities not only to visit and to get acquainted with VVER-440 NPP

  1. Evaluating the Effectiveness of an Antimicrobial Stewardship Program on Reducing the Incidence Rate of Healthcare-Associated Clostridium difficile Infection: A Non-Randomized, Stepped Wedge, Single-Site, Observational Study.

    Directory of Open Access Journals (Sweden)

    Giulio DiDiodato

    Full Text Available The incidence rate of healthcare-associated Clostridium difficile infection (HA-CDI is estimated at 1 in 100 patients. Antibiotic exposure is the most consistently reported risk factor for HA-CDI. Strategies to reduce the risk of HA-CDI have focused on reducing antibiotic utilization. Prospective audit and feedback is a commonly used antimicrobial stewardship intervention (ASi. The impact of this ASi on risk of HA-CDI is equivocal. This study examines the effectiveness of a prospective audit and feedback ASi on reducing the risk of HA-CDI.Single-site, 339 bed community-hospital in Barrie, Ontario, Canada. Primary outcome is HA-CDI incidence rate. Daily prospective and audit ASi is the exposure variable. ASi implemented across 6 wards in a non-randomized, stepped wedge design. Criteria for ASi; any intravenous antibiotic use for ≥ 48 hrs, any oral fluoroquinolone or oral second generation cephalosporin use for ≥ 48 hrs, or any antimicrobial use for ≥ 5 days. HA-CDI cases and model covariates were aggregated by ward, year and month starting September 2008 and ending February 2016. Multi-level mixed effect negative binomial regression analysis was used to model the primary outcome, with intercept and slope coefficients for ward-level random effects estimated. Other covariates tested for inclusion in the final model were derived from previously published risk factors. Deviance residuals were used to assess the model's goodness-of-fit.The dataset included 486 observation periods, of which 350 were control periods and 136 were intervention periods. After accounting for all other model covariates, the estimated overall ASi incidence rate ratio (IRR was 0.48 (95% 0.30, 0.79. The ASi effect was independent of antimicrobial utilization. The ASi did not seem to reduce the risk of Clostridium difficile infection on the surgery wards (IRR 0.87, 95% CI 0.45, 1.69 compared to the medicine wards (IRR 0.42, 95% CI 0.28, 0.63. The ward-level burden of

  2. Pharmacogenomics of antimicrobial agents.

    Science.gov (United States)

    Aung, Ar Kar; Haas, David W; Hulgan, Todd; Phillips, Elizabeth J

    2014-01-01

    Antimicrobial efficacy and toxicity varies between individuals owing to multiple factors. Genetic variants that affect drug-metabolizing enzymes may influence antimicrobial pharmacokinetics and pharmacodynamics, thereby determining efficacy and/or toxicity. In addition, many severe immune-mediated reactions have been associated with HLA class I and class II genes. In the last two decades, understanding of pharmacogenomic factors that influence antimicrobial efficacy and toxicity has rapidly evolved, leading to translational success such as the routine use of HLA-B*57:01 screening to prevent abacavir hypersensitivity reactions. This article examines recent advances in the field of antimicrobial pharmacogenomics that potentially affect treatment efficacy and toxicity, and challenges that exist between pharmacogenomic discovery and translation into clinical use.

  3. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... issue of antimicrobial resistance is that the subject material appears abstract and is complex. This video was ... can develop and spread. All FDA CVM produced material may be copied, reproduced, and distributed as long ...

  4. Antimicrobial resistance in wildlife

    OpenAIRE

    Vittecoq, M.; Godreuil, S.; Prugnolle, Franck; Durand, P.; Brazier, L; Renaud, N; Arnal, A.; Aberkane, S.; Jean-Pierre, H.; Gauthier-Clerc, M; Thomas, F.; Renaud, F.

    2016-01-01

    The spread of antimicrobial resistance is of major concern for human health and leads to growing economic costs. While it is increasingly hypothesized that wildlife could play an important role in antimicrobial-resistant bacteria dynamics, empirical data remain scarce. The present work builds on a systematic review of the available data in order to highlight the main information we have and to suggest research pathways that should be followed if we aim to fill the gaps in our current knowledg...

  5. Antimicrobial compounds in tears.

    Science.gov (United States)

    McDermott, Alison M

    2013-12-01

    The tear film coats the cornea and conjunctiva and serves several important functions. It provides lubrication, prevents drying of the ocular surface epithelia, helps provide a smooth surface for refracting light, supplies oxygen and is an important component of the innate defense system of the eye providing protection against a range of potential pathogens. This review describes both classic antimicrobial compounds found in tears such as lysozyme and some more recently identified such as members of the cationic antimicrobial peptide family and surfactant protein-D as well as potential new candidate molecules that may contribute to antimicrobial protection. As is readily evident from the literature review herein, tears, like all mucosal fluids, contain a plethora of molecules with known antimicrobial effects. That all of these are active in vivo is debatable as many are present in low concentrations, may be influenced by other tear components such as the ionic environment, and antimicrobial action may be only one of several activities ascribed to the molecule. However, there are many studies showing synergistic/additive interactions between several of the tear antimicrobials and it is highly likely that cooperativity between molecules is the primary way tears are able to afford significant antimicrobial protection to the ocular surface in vivo. In addition to effects on pathogen growth and survival some tear components prevent epithelial cell invasion and promote the epithelial expression of innate defense molecules. Given the protective role of tears a number of scenarios can be envisaged that may affect the amount and/or activity of tear antimicrobials and hence compromise tear immunity. Two such situations, dry eye disease and contact lens wear, are discussed here.

  6. New Brunswick Site annual environmental report for calendar year 1991, New Brunswick, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    Energy Technology Data Exchange (ETDEWEB)

    1992-09-01

    This document describes the environmental monitoring program at the New Brunswick Site (NBS) and surrounding area, implementation of the program, and monitoring results for 1991. The site, near New Brunswick,, New Jersey, is a 5.6-acre vacant, fenced, and grass-covered area. Environmental monitoring of NBS began in 1981 when the site was part of the US Department of Energy`s (DOE) Surplus Facilities Management Program. In 1990 responsibility for NBS was transferred to the Formerly Utilized Sites Remedial Action Program (FUSP.4P). FUSRAP is a DOE program to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the,early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental monitoring program at NBS includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-228, thorium-230, thorium-232, americium-241, cesium-137, plutonium-239, and total uranium in surface water, sediment, and groundwater. Several nonradiological parameters are also measured in groundwater, surface water, and sediments. Monitoring results are compared with applicable Environmental Protection Agency standards, DOE derived concentration guides, dose limits, and other requirements in DOE orders. Environmental standards are established to protect public health and the environment.

  7. Utilization of cervical cancer screening services and trends in screening positivity rates in a 'screen-and-treat' program integrated with HIV/AIDS care in Zambia.

    Directory of Open Access Journals (Sweden)

    Mulindi H Mwanahamuntu

    Full Text Available BACKGROUND: In the absence of stand-alone infrastructures for delivering cervical cancer screening services, efforts are underway in sub-Saharan Africa to dovetail screening with ongoing vertical health initiatives like HIV/AIDS care programs. Yet, evidence demonstrating the utilization of cervical cancer prevention services in such integrated programs by women of the general population is lacking. METHODS: We analyzed program operations data from the Cervical Cancer Prevention Program in Zambia (CCPPZ, the largest public sector programs of its kind in sub-Saharan Africa. We evaluated patterns of utilization of screening services by HIV serostatus, examined contemporaneous trends in screening outcomes, and used multivariable modeling to identify factors associated with screening test positivity. RESULTS: Between January 2006 and April 2011, CCPPZ services were utilized by 56,247 women who underwent cervical cancer screening with visual inspection with acetic acid (VIA, aided by digital cervicography. The proportion of women accessing these services who were HIV-seropositive declined from 54% to 23% between 2006-2010, which coincided with increasing proportions of HIV-seronegative women (from 22% to 38% and women whose HIV serostatus was unknown (from 24% to 39% (all p-for trend<0.001. The rates of VIA screening positivity declined from 47% to 17% during the same period (p-for trend <0.001, and this decline was consistent across all HIV serostatus categories. After adjusting for demographic and sexual/reproductive factors, HIV-seropositive women were more than twice as likely (Odds ratio 2.62, 95% CI 2.49, 2.76 to screen VIA-positive than HIV-seronegative women. CONCLUSIONS: This is the first 'real world' demonstration in a public sector implementation program in a sub-Saharan African setting that with successful program scale-up efforts, nurse-led cervical cancer screening programs targeting women with HIV can expand and serve all women

  8. Antimicrobial outcomes in plasma medicine

    Science.gov (United States)

    Ryan, Thomas P.; Stalder, Kenneth R.; Woloszko, Jean

    2015-03-01

    Plasma is referred to as the fourth state of matter and is frequently generated in the environment of a strong electric field. The result consists of highly reactive species--ions, electrons, reactive atoms and molecules, and UV radiation. Plasma Medicine unites a number of fields, including Physics, Plasma Chemistry, Cell Biology, Biochemistry, and Medicine. The treatment modality utilizes Cold Atmospheric Plasma (CAP), which is able to sterilize and treat microbes in a nonthermal manner. These gas-based plasma systems operate at close to room temperature and atmospheric pressure, making them very practical for a range of potential treatments and are highly portable for clinical use throughout the health care system. The hypothesis is that gas based plasma kills bacteria, fungus, and viruses but spares mammalian cells. This paper will review systematic work which shows examples of systems and performance in regards to antimicrobial effects and the sparing of mammalian cells. The mechanism of action will be discussed, as well as dosing for the treatment of microbial targets, including sterilization processes, another important healthcare need. In addition, commercial systems will be overviewed and compared, along with evidence-based, patient results. The range of treatments cover wound treatment and biofilms, as well as antimicrobial treatment, with little chance for resistance and tolerance, as in drug regimens. Current clinical studies include applications in dentistry, food treatment, cancer treatment, wound treatment for bacteria and biofilms, and systems to combat health care related infections.

  9. Evaluation of lead/carbon devices for utility applications : a study for the DOE Energy Storage Program.

    Energy Technology Data Exchange (ETDEWEB)

    Walmet, Paula S. (MeadWestvaco Corporation,North Charleston, SC)

    2009-06-01

    This report describes the results of a three-phase project that evaluated lead-based energy storage technologies for utility-scale applications and developed carbon materials to improve the performance of lead-based energy storage technologies. In Phase I, lead/carbon asymmetric capacitors were compared to other technologies that used the same or similar materials. At the end of Phase I (in 2005) it was found that lead/carbon asymmetric capacitors were not yet fully developed and optimized (cost/performance) to be a viable option for utility-scale applications. It was, however, determined that adding carbon to the negative electrode of a standard lead-acid battery showed promise for performance improvements that could be beneficial for use in utility-scale applications. In Phase II various carbon types were developed and evaluated in lead-acid batteries. Overall it was found that mesoporous activated carbon at low loadings and graphite at high loadings gave the best cycle performance in shallow PSoC cycling. Phase III studied cost/performance benefits for a specific utility application (frequency regulation) and the full details of this analysis are included as an appendix to this report.

  10. Children's tooth decay in a public health program to encourage low-income pregnant women to utilize dental care

    OpenAIRE

    Shirtcliff R Mike; Sutherland Marilynn; Milgrom Peter; Ludwig Sharity; Smolen Darlene

    2010-01-01

    Abstract Background A community-based public health program to provide a dental home for women covered by the Oregon Health Plan (Medicaid) in Klamath County, Oregon USA was instituted with the long-term goal to promote preventive oral care for both mothers and their new infants provided by dental managed care companies. Methods As part of the evaluation of the program, children in Klamath and comparable non-program counties were examined in their 2nd year of life to begin to determine if ben...

  11. When Antimicrobial Stewardship Isn't Watching: The Educational Impact of Critical Care Prospective Audit and Feedback.

    Science.gov (United States)

    Fleming, Dimitra; Ali, Karim F; Matelski, John; D'Sa, Ryan; Powis, Jeff

    2016-09-01

    Prospective audit and feedback (PAF) is an effective strategy to optimize antimicrobial use in the critical care setting, yet whether skills gained during PAF influence future antimicrobial prescribing is uncertain. This multisite study demonstrates that knowledge learned during PAF is translated and incorporated into the practice of critical care physicians even when not supported by an antimicrobial stewardship program. PMID:27382599

  12. Colonie Interim Storage Site: Annual site environmental report, Colonie, New York, Calendar year 1986: Formerly Utilized Sites Remedial Action Program (FUSRAP)

    International Nuclear Information System (INIS)

    During 1986, the environmental monitoring program continued at the Colonie Interim Storage Site (CISS), a US Department of Energy (DOE) facility located in Colonie, New York. The CISS is part of the Formerly Utilized Sites Remedial Action Program (FUSRAP), a DOE program to decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation's atomic energy program or from commercial operations causing conditions that Congress has mandated DOE to remedy. As part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Appropriations Act, remedial action is being conducted at the site and at vicinity properties by Bechtel National Inc. (BNI), Project Management Contractor for FUSRAP. The environmental monitoring program is also carried out by BNI. The monitoring program at the CISS measures external gamma radiation levels as well as uranium and radium-226 concentrations in surface water, groundwater, and sediment. To verify that the site is in compliance with the DOE radiation protection standard and to assess the potential effect of the site on public health, the radiation dose was calculated for the maximally exposed individual. Based on the conservative scenario described in the report, the maximally exposed individual would receive an annual external exposure approximately equivalent to 5% of the DOE radiation protection standard of 100 mrem/y. Results of 1986 monitoring show that the CISS is in compliance with the DOE radiation protection standard. 14 refs., 9 figs., 9 tabs

  13. Colonie Interim Storage Site environmental report for calendar year 1992, 1130 Central Avenue, Colonie, New York. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    This report describes the environmental surveillance program at the Colonie Interim Storage Site (CISS) and provides the results for 1992. The site is located in eastern New York State, approximately 6.4 km (4.0 mi) northwest of downtown Albany. From 1958 to 1984, National Lead (NL) Industries used the facility to manufacture various components from depleted and enriched uranium natural thorium. Environmental monitoring of CISS began in 1984 when Congress added, the site to the US Department of Energy`s (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP is a program established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental surveillance program at CISS includes sampling networks for external gamma radiation exposure and for thorium-232 and total uranium concentrations in surface water, sediment, and groundwater. Several chemical parameters are also measured in groundwater, including total metals, volatile organics, and water quality parameters. This surveillance program assists in fulfilling the DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses. Results are compared with applicable Environmental Protection Agency (EPA) and New York State Department of Environmental Conservation (NYSDEC) standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements.

  14. User's guide to the MESOI diffusion model and to the utility programs UPDATE and LOGRVU

    Energy Technology Data Exchange (ETDEWEB)

    Athey, G.F.; Allwine, K.J.; Ramsdell, J.V.

    1981-11-01

    MESOI is an interactive, Lagrangian puff trajectory diffusion model. The model is documented separately (Ramsdell and Athey, 1981); this report is intended to provide MESOI users with the information needed to successfully conduct model simulations. The user is also provided with guidance in the use of the data file maintenance and review programs; UPDATE and LOGRVU. Complete examples are given for the operaton of all three programs and an appendix documents UPDATE and LOGRVU.

  15. Two programs of utility in the performance of histograms and Dalitz plots by means of a CALCOMP-563 plotter

    International Nuclear Information System (INIS)

    Full description of the whole structure and of the operation of every routine is given for both programs, as well as the data setup in punched cards and binary tape. To help the users we present and comment several examples of data sets and the corresponding output plots. The list of instructions in FORTRAN IV language is included. The same version of both programs is operative in the series 7090-94-IBM and 1106-08-UNIVAC. (Author)

  16. Empowering immigrant youth in Chicago: Utilizing CBPR to document the impact of a Youth Health Service Corps program

    OpenAIRE

    Ferrera, MJ; Sacks, TK; M. Perez; Nixon, JP; Asis, D; Coleman, WL

    2015-01-01

    Community-based participatory research (CBPR) is an approach that engages community residents with a goal of influencing change in community health systems, programs, or policies. As such, CBPR is particularly relevant to historically marginalized communities that often have not directly benefited from the knowledge research produces. This article analyzes a youth empowerment program, Chicago's Youth Health Service Corps, from a CBPR perspective. The purpose of this work was (1) to discuss Yo...

  17. Variation in Outpatient Oral Antimicrobial Use Patterns among Canadian Provinces, 2000 to 2010

    Directory of Open Access Journals (Sweden)

    Shiona K Glass-Kaastra

    2014-01-01

    Full Text Available BACKGROUND: The volume and patterns of antimicrobial drug use are key variables to consider when developing guidelines for prescribing, and programs to address stewardship and combat the increasing prevalence of antimicrobial resistant pathogens. Because drug programs are regulated at the provincial level, there is an expectation that antibiotic use may vary among provinces.

  18. Antimicrobial Stewardship: The Need to Cover All Bases.

    Science.gov (United States)

    Friedman, N Deborah

    2013-01-01

    Increasing antimicrobial resistance has necessitated an approach to guide the use of antibiotics. The necessity to guide antimicrobial use via stewardship has never been more urgent. The decline in anti-infective innovation and the failure of currently available antimicrobials to treat some serious infections forces clinicians to change those behaviors that drive antimicrobial resistance. The majority of antimicrobial stewardship (AMS) programs function in acute-care hospitals, however, hospitals are only one setting where antibiotics are prescribed. Antimicrobial use is also high in residential aged care facilities and in the community. Prescribing in aged care is influenced by the fact that elderly residents have lowered immunity, are susceptible to infection and are frequently colonized with multi-resistant organisms. While in the community, prescribers are faced with public misconceptions about the effectiveness of antibiotics for many upper respiratory tract illnesses. AMS programs in all of these locations must be sustainable over a long period of time in order to be effective. A future with effective antimicrobials to treat bacterial infection will depend on AMS covering all of these bases. This review discusses AMS in acute care hospitals, aged care and the community and emphasizes that AMS is critical to patient safety and relies on government, clinician and community engagement.

  19. Antimicrobial Stewardship: The Need to Cover All Bases

    Directory of Open Access Journals (Sweden)

    N. Deborah Friedman

    2013-08-01

    Full Text Available Increasing antimicrobial resistance has necessitated an approach to guide the use of antibiotics. The necessity to guide antimicrobial use via stewardship has never been more urgent. The decline in anti-infective innovation and the failure of currently available antimicrobials to treat some serious infections forces clinicians to change those behaviors that drive antimicrobial resistance. The majority of antimicrobial stewardship (AMS programs function in acute-care hospitals, however, hospitals are only one setting where antibiotics are prescribed. Antimicrobial use is also high in residential aged care facilities and in the community. Prescribing in aged care is influenced by the fact that elderly residents have lowered immunity, are susceptible to infection and are frequently colonized with multi-resistant organisms. While in the community, prescribers are faced with public misconceptions about the effectiveness of antibiotics for many upper respiratory tract illnesses. AMS programs in all of these locations must be sustainable over a long period of time in order to be effective. A future with effective antimicrobials to treat bacterial infection will depend on AMS covering all of these bases. This review discusses AMS in acute care hospitals, aged care and the community and emphasizes that AMS is critical to patient safety and relies on government, clinician and community engagement.

  20. Geothermal direct-heat utilization assistance: Federal assistance program. Quarterly project progress report, October--December 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    The report summarizes geothermal technical assistance, R&D and technology transfer activities of the Geo-Heat Center at Oregon Institute of Technology for the first quarter of FY-96. It describes 90 contacts with parties during this period related to technical assistance with geothermal direct heat projects. Areas dealt with include geothermal heat pumps, space heating, greenhouses, aquaculture, equipment and resources. Research activities are summarized on low-temperature resource assessment, geothermal district heating system cost evaluation and silica waste utilization project. Outreach activities include the publication of a geothermal direct use Bulletin, dissemination of information, geothermal library, technical papers and seminars, development of a webpage, and progress monitor reports on geothermal resources and utilization.

  1. Sustainable Energy Production from Old Coal-fired Thermal Power Plants beyond 2016 Utilizing Major Rehabilitation Program

    OpenAIRE

    Cingoski, Vlatko; Tanurkov, Dimitar; Papsterevski, Kosta

    2014-01-01

    Due to its natural abundance and proven exploitation history, coal still represents an important fuel resource for electricity production worldwide. However, as a result of its unfavorable environmental impact and negative emission footprint, recently, a lot of efforts have been taken to provide more “environment friendly” energy producing burning coal, such as Carbon Capture Storage (CCS), utilization of low NOX burners, installation of desulphurization facilities, etc. These activities have...

  2. Antimicrobials, stress and mutagenesis.

    Directory of Open Access Journals (Sweden)

    Alexandro Rodríguez-Rojas

    2014-10-01

    Full Text Available Cationic antimicrobial peptides are ancient and ubiquitous immune effectors that multicellular organisms use to kill and police microbes whereas antibiotics are mostly employed by microorganisms. As antimicrobial peptides (AMPs mostly target the cell wall, a microbial 'Achilles heel', it has been proposed that bacterial resistance evolution is very unlikely and hence AMPs are ancient 'weapons' of multicellular organisms. Here we provide a new hypothesis to explain the widespread distribution of AMPs amongst multicellular organism. Studying five antimicrobial peptides from vertebrates and insects, we show, using a classic Luria-Delbrück fluctuation assay, that cationic antimicrobial peptides (AMPs do not increase bacterial mutation rates. Moreover, using rtPCR and disc diffusion assays we find that AMPs do not elicit SOS or rpoS bacterial stress pathways. This is in contrast to the main classes of antibiotics that elevate mutagenesis via eliciting the SOS and rpoS pathways. The notion of the 'Achilles heel' has been challenged by experimental selection for AMP-resistance, but our findings offer a new perspective on the evolutionary success of AMPs. Employing AMPs seems advantageous for multicellular organisms, as it does not fuel the adaptation of bacteria to their immune defenses. This has important consequences for our understanding of host-microbe interactions, the evolution of innate immune defenses, and also sheds new light on antimicrobial resistance evolution and the use of AMPs as drugs.

  3. Analysis of antimicrobial agents utilization and the main pathogenic bacteria resistance rate in our hospital during 2013%我院2013年抗菌药物使用量与主要病原菌耐药率分析

    Institute of Scientific and Technical Information of China (English)

    刘俊; 安益国; 刘建军

    2014-01-01

    分析我院抗菌药物使用情况和主要病原菌的耐药率,为临床合理使用和管理抗菌药物提供参考。方法采用回顾性调查方法,分别统计2013年住院患者抗菌药物用药频度(DDDs)和临床主要病原菌对常用抗菌药物的耐药率,采用SPSS 13.0软件对抗菌药物使用频度和主要病原菌耐药率进行相关性分析。结果2013年头孢菌素类药物使用最频繁,其中头孢硫脒DDDs排第一,其次为左氧氟沙星注射液;临床主要分离菌以革兰阴性菌为主,分离率最高的细菌是大肠埃希菌;大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌对头孢类药物的耐药率相对较高;金黄色葡萄球菌对青霉素的耐药率最高。结论抗菌药物DDDs与细菌耐药率有一定相关性。医院应加强细菌监测,提高病原送检率,规范抗菌药物的应用,减少细菌耐药性的产生。%Objective To analyze antimicrobial agents utilization and the main pathogenic bacteria resistance rate (MP-BRR) in our hospital,and to provide reference for the clinical rational use and the management of the antimicrobial agents. Methods The DDDs of inpatient and the drug-resistance rate of clinical main pathogenic to commonly used antimicrobial a-gents were analyzed statistically and respectively during 2013 by retrospective survey , and the correlation analysis between DDDs and MPBRR was performed simultaneously by SPSS 13.0 software. Results The most frequent consumption of antimi-crobial agents was cephalosporins in 2013, the DDDs ranked first, being followed by levofloxacin injection; the major clinical isolation was identified to the Gram-negative bacteria, E. Coli had the highest detection rate;the relatively high drug-resistance rate of cephalosporin were shared with E. Coli, P. aeruginosa, Klebsiella pneumoniae and Acinetobacter baumanni. The staphy-lococcus aureus was in a peak drug resistance rate for penicillin

  4. General principles of antimicrobial therapy.

    Science.gov (United States)

    Leekha, Surbhi; Terrell, Christine L; Edson, Randall S

    2011-02-01

    Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community.

  5. General principles of antimicrobial therapy.

    Science.gov (United States)

    Leekha, Surbhi; Terrell, Christine L; Edson, Randall S

    2011-02-01

    Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community. PMID:21282489

  6. Antimicrobial stewardship: Limits for implementation

    NARCIS (Netherlands)

    Sinha, Bhanu

    2014-01-01

    Antibiotic stewardship programme (ASP) is a multifaceted approach to improve patients' clinical outcomes, prevent the emergence of antimicrobial resistance, and reduce hospital costs by prudent and focused antimicrobial use. Development of local treatment guidelines according to local ecology, rapid

  7. Geothermal Program Review X: proceedings. Geothermal Energy and the Utility Market -- the Opportunities and Challenges for Expanding Geothermal Energy in a Competitive Supply Market

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    Each year the Geothermal Division of the US Department of Energy conducts an in-depth review of its entire geothermal R&D program. The conference serves several purposes: a status report on current R&D activities, an assessment of progress and problems, a review of management issues, and a technology transfer opportunity between DOE and the US geothermal city. This year`s conference, Program Review X, was held in San Francisco on March 24--26, 1992. The theme of the review, ``Geothermal Energy and the Utility Market -- The Opportunities and Challenges for Expanding Geothermal Energy in a Competitive Supply Market,`` focused on the needs of the electric utility sector. Geothermal energy, with its power capacity potential of 10 GWe by the year 2010, can provide reliable, enviromentally clean electricity which can help offset the projected increase in demand. Program Review X consisted of seven sessions including an opening session with presentations by Mr. Vikram Budhraja, Vice President of System Planning and Operations, Southern California Edison Company, and Mr. Richard Jaros, President and Chief Operating Officer, California Energy Company. The six technical sessions included presentations by the relevant field researchers covering DOE-sponsored R&D in hydrothermal, hot dry rock, and geopressured energy. Individual projects are processed separately for the data bases.

  8. Antimicrobial Peptides (AMPs

    Directory of Open Access Journals (Sweden)

    Mehrzad Sadredinamin

    2016-04-01

    Full Text Available Antimicrobial peptides (AMPs are extensive group of molecules that produced by variety tissues of invertebrate, plants, and animal species which play an important role in their immunity response. AMPs have different classifications such as; biosynthetic machines, biological sources, biological functions, molecular properties, covalent bonding patterns, three dimensional structures, and molecular targets.These molecules have multidimensional properties including antimicrobial activity, antiviral activity, antifungal activity, anti-parasite activity, biofilm control, antitumor activity, mitogens activity and linking innate to adaptive immunity that making them promising agents for therapeutic drugs. In spite of this advantage of AMPs, their clinical developments have some limitation for commercial development. But some of AMPs are under clinical trials for the therapeutic purpose such as diabetic foot ulcers, different bacterial infections and tissue damage. In this review, we emphasized on the source, structure, multidimensional properties, limitation and therapeutic applications of various antimicrobial peptides.

  9. Maywood Interim Storage Site environmental report for calendar year 1992, 100 West Hunter Avenue, Maywood, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    This report describes the environmental surveillance program at the Maywood Interim Storage Site (MISS) and provides the results for 1992. Environmental monitoring of MISS began in 1984, when the site was assigned to DOE by Congress through the Energy and Water Development Appropriations Act and was placed under DOE`s Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. MISS is part of a National Priorities List (NPL) site. The environmental surveillance program at MISS includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analysis includes metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling the DOE objective of measuring and monitoring effluents from DOE activities and calculating hypothetical doses to members of the general public. Monitoring results are compared with applicable Environmental Protection Agency (EPA) and state standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements. Environmental standards are established to protect public health and the environment. The radiological data for all media sampled support the conclusion that doses to the public are not distinguishable from natural background radiation.

  10. Evaluating the McDonald's business model for HIV prevention among truckers to improve program coverage and service utilization in India, 2004–2010

    Directory of Open Access Journals (Sweden)

    Tirumalasetti Rao V

    2013-02-01

    Full Text Available Vasudha Tirumalasetti Rao,1 Bidhubhusan Mahapatra,2 Sachin Juneja,1 Indra R Singh11Transport Corporation of India Foundation, Gurgaon, Haryana, India 2Population Council, New Delhi, IndiaBackground: This study describes the experiences and results of a large-scale human immunodeficiency virus (HIV prevention intervention for long-distance truck drivers operating on the national highways of India.Methods: The intervention for long-distance truckers started in 2004 across 34 trans-shipment locations. However, due to poor coverage and utilization of services by truckers in the initial 18-month period, the intervention was redesigned to focus on only 17 trans-shipment locations. The redesigned intervention model was based on the McDonald's business franchise model where the focus is on optimal placement of services, supported with branding and standardization of services offered, and a surround sound communication approach. Program output indicators were assessed using program monitoring data over 7 years (2004–2010 and two rounds of cross-sectional behavioral surveys conducted in January 2008 (n = 1402 and July 2009 (n = 1407.Results: The number of truckers contacted per month per site increased from 374 in 2004 to 4327 in 2010. Analysis of survey data showed a seven-fold increase in clinic visits in the past 12 months from 2008 to 2009 (21% versus 63%, P < 0.001. A significant increase was also observed in the percentage of truckers who watched street plays (10% to 56%, P < 0.001, and participated in health exhibitions (6% to 35%, P < 0.001. Furthermore, an increase from round 1 to round 2 was observed in the percentage who received condoms (13% to 22%, P < 0.001, and attended one-one counseling (15% to 21%, P < 0.01. Treatment-seeking from program clinics for symptoms related to sexually transmitted infections increased six-fold during this period (16% versus 50%, P < 0.001.Conclusion: Adoption of a business model for HIV prevention helped to

  11. Antimicrobial Graft Copolymer Gels.

    Science.gov (United States)

    Harvey, Amanda C; Madsen, Jeppe; Douglas, C W Ian; MacNeil, Sheila; Armes, Steven P

    2016-08-01

    In view of the growing worldwide rise in microbial resistance, there is considerable interest in designing new antimicrobial copolymers. The aim of the current study was to investigate the relationship between antimicrobial activity and copolymer composition/architecture to gain a better understanding of their mechanism of action. Specifically, the antibacterial activity of several copolymers based on 2-(methacryloyloxy)ethyl phosphorylcholine [MPC] and 2-hydroxypropyl methacrylate (HPMA) toward Staphylococcus aureus was examined. Both block and graft copolymers were synthesized using either atom transfer radical polymerization or reversible addition-fragmentation chain transfer polymerization and characterized via (1)H NMR, gel permeation chromatography, rheology, and surface tensiometry. Antimicrobial activity was assessed using a range of well-known assays, including direct contact, live/dead staining, and the release of lactate dehydrogenase (LDH), while transmission electron microscopy was used to study the morphology of the bacteria before and after the addition of various copolymers. As expected, PMPC homopolymer was biocompatible but possessed no discernible antimicrobial activity. PMPC-based graft copolymers comprising PHPMA side chains (i.e. PMPC-g-PHPMA) significantly reduced both bacterial growth and viability. In contrast, a PMPC-PHPMA diblock copolymer comprising a PMPC stabilizer block and a hydrophobic core-forming PHPMA block did not exhibit any antimicrobial activity, although it did form a biocompatible worm gel. Surface tensiometry studies and LDH release assays suggest that the PMPC-g-PHPMA graft copolymer exhibits surfactant-like activity. Thus, the observed antimicrobial activity is likely to be the result of the weakly hydrophobic PHPMA chains penetrating (and hence rupturing) the bacterial membrane. PMID:27409712

  12. Children's tooth decay in a public health program to encourage low-income pregnant women to utilize dental care

    Directory of Open Access Journals (Sweden)

    Shirtcliff R Mike

    2010-02-01

    Full Text Available Abstract Background A community-based public health program to provide a dental home for women covered by the Oregon Health Plan (Medicaid in Klamath County, Oregon USA was instituted with the long-term goal to promote preventive oral care for both mothers and their new infants provided by dental managed care companies. Methods As part of the evaluation of the program, children in Klamath and comparable non-program counties were examined in their 2nd year of life to begin to determine if benefits accrued to the offspring of the mothers in Klamath County. Results Eighty-five and 58.9% of the children were caries free in the Klamath and comparison county samples, respectively (RR = 1.48, 95% CI 1.13, 1.93. The mean (SD number of teeth with any decay was .75 (2.5 in the test population and 1.6 (2.5 in the comparison population (t = 2.08, p = .04. Conclusions The assessment showed that children of mothers in the Klamath County program were about one and a half times more likely to be caries free than children in the comparison counties. Additional controlled studies are being undertaken.

  13. From Theory to Practice: Utilizing Integrative Seminars as Bookends to the Master of Public Administration Program of Study

    Science.gov (United States)

    Stout, Margaret; Holmes, Maja Husar

    2013-01-01

    Integrative seminar style courses are most often used as an application-oriented capstone in place of a thesis or comprehensive exam requirement in Master of Public Administration (MPA) degree programs. This article describes and discusses the benefits of a unique approach of one National Association of Schools of Public Affairs and Administration…

  14. The Impact of Commercial Health Plan Prior Authorization Programs on the Utilization of Services for Low Back Pain

    Science.gov (United States)

    Goodman, Robert M.; Powell, Corey C.; Park, Paul

    2016-01-01

    Study Design. An observational study. Objective. The aim of this study was to evaluate the impact of a health plan's prior authorization (PA) programs for low back pain (LBP) in a non-Medicare population by assessing changes in pre-surgical nonoperative care; lumbar fusion trends; and overall back surgery rates compared with another health plan with a similar program and national benchmarks. The PA programs require mandatory physiatrist consultation before surgical evaluation, with subsequent additional LBP surgery PA. Summary of Background Data. LBP is prevalent and concern exists that spinal fusion is overutilized for LBP. Methods. Annual rates of lumbar fusion trended over 6 years, and analysis of changes in standardized costs for LBP-related services among a 501-member subset who underwent lumbar fusion before and after program implementations, during the period January 1, 2008, through December 31, 2013, among commercial members aged 18 and 65 years enrolled in a health maintenance organization with commercial membership averaging >500,000 annually. Results. After initiation of the physiatrist PA in December 2010, lumbar fusions decreased from 76.27/100,000 in 2010 to 62.63/100,000 in 2011 with subsequent increases to 64.24/100,000 and 73.84/100,000 in years 2012 and 2013. For members who had lumbar fusion, per-member, pre-surgical costs increased by $2,233 with the physiatrist PA and an additional $1,370 with implementation of the LBP surgery PA (March 2013). Spinal injections and inpatient admissions were the greatest contributors to the overall increase in costs. The physiatrist and LBP surgery PA programs were also associated with lengthening of LBP episodes ending in surgery by 309 and 198 days. Conclusion. Mandatory referral to a physiatrist before surgical evaluation did not result in persistent reduction in lumbar fusions. Instead, these programs were associated with the unintended consequence of increased costs from more nonoperative care for only a

  15. Virginia Solar Pathways Project: Economic Study of Utility-Administered Solar Programs: Soft Costs, Community Solar, and Tax Normalization Considerations

    Energy Technology Data Exchange (ETDEWEB)

    Reiter, Emerson [National Renewable Energy Lab. (NREL), Golden, CO (United States); Lowder, Travis [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mathur, Shivani [National Renewable Energy Lab. (NREL), Golden, CO (United States); Mercer, Megan [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-06-23

    This report presents economic considerations for solar development in support of the Virginia Solar Pathways Project (VSPP), an effort funded by the U.S. Department of Energy (DOE) SunShot Initiative that seeks to develop a collaborative utility-administered solar strategy for the Commonwealth of Virginia. The results presented are intended to be considered alongside the results of other studies conducted under the VSPP that evaluate the impacts of solar energy on the electric distribution, transmission, and generation systems in Virginia.

  16. Geothermal direct-heat utilization assistance. Quarterly project progress report, July 1996--September 1996. Federal Assistance Program

    Energy Technology Data Exchange (ETDEWEB)

    Lienau, P.

    1996-11-01

    This report summarizes geothermal technical assistance, R&D and technology transfer activities of the Geo-Heat Center at Oregon Institute of Technology for the fourth quarter of FY-96. It describes 152 contacts with parties during this period related to technical assistance with geothermal direct heat projects. Areas dealt with include geothermal heat pumps, space heating, greenhouses, aquaculture, equipment, economics and resources. Research activities are summarized on greenhouse peaking. Outreach activities include the publication of a geothermal direct use Bulletin, dissemination of information, geothermal library, technical papers and seminars, and progress monitor reports on geothermal resources and utilization.

  17. 21st Century Power Partnership Fellowship Program: Supporting Next-generation Planning Modeling Practices at South Africa's Power Utility Eskom

    Energy Technology Data Exchange (ETDEWEB)

    Zinaman, Owen

    2016-10-01

    This presentation details the 21st Century Power Partnership's fellowship program accomplishments from 2016. This fellowship brought two fellows from South Africa's power utility, Eskom, to the U.S. Department of Energy's National Renewable Energy Laboratory. The fellows spent two weeks working to improve the fidelity of Eskom's PLEXOS long-term and short-term models, which are used in long-term generation planning exercises and capacity adequacy assessments. The fellows returned to Eksom equipped with a new suite of tools and skills to enhance Eksom's PLEXOS modeling capabilities.

  18. Electric utility transmission and distribution upgrade deferral benefits from modular electricity storage : a study for the DOE Energy Storage Systems Program.

    Energy Technology Data Exchange (ETDEWEB)

    Eyer, James M. (Distributed Utility Associates, Inc., Livermore, CA)

    2009-06-01

    The work documented in this report was undertaken as part of an ongoing investigation of innovative and potentially attractive value propositions for electricity storage by the United States Department of Energy (DOE) and Sandia National Laboratories (SNL) Electricity Storage Systems (ESS) Program. This study characterizes one especially attractive value proposition for modular electricity storage (MES): electric utility transmission and distribution (T&D) upgrade deferral. The T&D deferral benefit is characterized in detail. Also presented is a generalized framework for estimating the benefit. Other important and complementary (to T&D deferral) elements of possible value propositions involving MES are also characterized.

  19. A program for calculating load coefficient matrices utilizing the force summation method, L218 (LOADS). Volume 2: Supplemental system design and maintenance document

    Science.gov (United States)

    Anderson, L. R.; Miller, R. D.

    1979-01-01

    The LOADS computer program L218 which calculates dynamic load coefficient matrices utilizing the force summation method is described. The load equations are derived for a flight vehicle in straight and level flight and excited by gusts and/or control motions. In addition, sensor equations are calculated for use with an active control system. The load coefficient matrices are calculated for the following types of loads: (1) translational and rotational accelerations, velocities, and displacements; (2) panel aerodynamic forces; (3) net panel forces; and (4) shears, bending moments, and torsions.

  20. Utilization of 3-Month Yoga Program for Adults at High Risk for Type 2 Diabetes: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Kyeongra Yang

    2011-01-01

    Full Text Available Various modes of physical activity, combined with dieting, have been widely recommended to prevent or delay type 2 diabetes. Among these, yoga holds promise for reducing risk factors for type 2 diabetes by promoting weight loss, improving glucose levels and reducing blood pressure and lipid levels. This pilot study aimed to assess the feasibility of implementing a 12-week yoga program among adults at high risk for type 2 diabetes. Twenty-three adults (19 Whites and 4 non-Whites were randomly assigned to the yoga intervention group or the educational group. The yoga group participated in a 3-month yoga intervention with sessions twice per week and the educational group received general health educational materials every 2 weeks. All participants completed questionnaires and had blood tests at baseline and at the end of 3 months. Effect sizes were reported to summarize the efficacy of the intervention. All participants assigned to the yoga intervention completed the yoga program without complication and expressed high satisfaction with the program (99.2%. Their yoga session attendance ranged from 58.3 to 100%. Compared with the education group, the yoga group experienced improvements in weight, blood pressure, insulin, triglycerides and exercise self-efficacy indicated by small to large effect sizes. This preliminary study indicates that a yoga program would be a possible risk reduction option for adults at high risk for type 2 diabetes. In addition, yoga holds promise as an approach to reducing cardiometabolic risk factors and increasing exercise self-efficacy for this group.

  1. Controversies in Antimicrobial Stewardship: Focus on New Rapid Diagnostic Technologies and Antimicrobials.

    Science.gov (United States)

    Wenzler, Eric; Wong, Jordan R; Goff, Debra A; Jankowski, Christopher A; Bauer, Karri A

    2016-01-01

    Antimicrobial stewardship programs (ASPs) are challenged with ensuring appropriate antimicrobial use while minimizing expenditures. ASPs have consistently demonstrated improved patient outcomes and significant cost reductions but are continually required to justify the costs of their existence and interventions due to the silo mentality often adopted by hospital administrators. As new technologies and antimicrobials emerge, ASPs are in a constant tug-of-war between providing optimal clinical outcomes and ensuring cost containment. Additionally, robust data on cost-effectiveness of new rapid diagnostic technologies and antimicrobials with subsequent ASP interventions to provide justification are lacking. As the implementation of an ASP will soon be mandatory for acute care hospitals in the United States, ASPs must find ways to justify novel interventions to align themselves with healthcare administrators. This review provides a framework for the justification of implementing a rapid diagnostic test or adding a new antimicrobial to formulary with ASP intervention, reviews approaches to demonstrating cost-effectiveness, and proposes methods for which ASPs may reduce healthcare expenditures via alternative tactics. PMID:27025521

  2. The quality of outpatient antimicrobial prescribing: A comparison between two areas of northern and southern Europe

    DEFF Research Database (Denmark)

    Malo, Sara; Bjerrum, Lars; Feja, Cristina;

    2014-01-01

    Institute for Health Data and Disease Control in Denmark, and from the Aragon Information System of Drug Consumption. The number of Defined Daily Doses (DDD) of the different substances were calculated, and the quality of the antimicrobial prescription was analysed using the 'Drug Utilization 90 %' method...... and the European Surveillance of Antimicrobial Consumption (ESAC) quality indicators for outpatient antimicrobial use. RESULTS: The majority of the prescriptions (90 % of total DDD) were comprised of 14 (of 39) different antimicrobials in Denmark, based mainly on narrow spectrum penicillin, and 11 (of 59...

  3. Wayne Interim Storage Site environmental report for calendar year 1992, 868 Black Oak Ridge Road, Wayne, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    This report describes the environmental surveillance program at the Wayne Interim Storage Site (WISS) and provides the results for 1992. The fenced, site, 32 km (20 mi) northwest of Newark, New Jersey, was used between 1948 and 1971 for commercial processing of monazite sand to separate natural radioisotopes - predominantly thorium. Environmental surveillance of WISS began in 1984 in accordance with Department of Energy (DOE) Order 5400.1 when Congress added the site to DOE`s Formerly Utilized Sites Remedial Action Program (FUSRAP). The environmental surveillance program at WISS includes sampling networks for radon and thoron in air; external gamma radiation exposure; radium-226, radium-228, thorium-230, thorium-232, total uranium, and several chemicals in surface water and sediment; and total uranium, radium-226, radium-228, thorium-230, thorium-232, and organic and inorganic chemicals in groundwater. Monitoring results are compared with applicable Environmental Protection Agency (EPA) and state standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements. This monitoring program assists in fulfilling the DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses. Results for environmental surveillance in 1992 show that the concentrations of all radioactive and most chemical contaminants were below applicable standards.

  4. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... En Español Search FDA Submit search Popular Content Home Food Drugs Medical Devices Radiation-Emitting Products Vaccines, ... Biologics Animal & Veterinary Cosmetics Tobacco Products Animal & Veterinary Home Animal & Veterinary Safety & Health Antimicrobial Resistance Animation of ...

  5. Antimicrobial properties of berries

    OpenAIRE

    Puupponen-Pimiä, Riitta

    2007-01-01

    Berries, especially their antimicrobial properties, have been studied intensively at VTT over the past ten years in several research projects. In these in vitro studies phenolic berry extracts of common Nordic berries selectively inhibited the growth of harmful bacteria and human intestinal pathogens, without affecting the growth of beneficial lactic acid bacteria.

  6. Triclosan antimicrobial polymers

    Science.gov (United States)

    Petersen, Richard C.

    2016-01-01

    Triclosan antimicrobial molecular fluctuating energies of nonbonding electron pairs for the oxygen atom by ether bond rotations are reviewed with conformational computational chemistry analyses. Subsequent understanding of triclosan alternating ether bond rotations is able to help explain several material properties in Polymer Science. Unique bond rotation entanglements between triclosan and the polymer chains increase both the mechanical properties of polymer toughness and strength that are enhanced even better through secondary bonding relationships. Further, polymer blend compatibilization is considered due to similar molecular relationships and polarities. With compatibilization of triclosan in polymers a more uniform stability for nonpolar triclosan in the polymer solid state is retained by the antimicrobial for extremely low release with minimum solubility into aqueous solution. As a result, triclosan is projected for long extended lifetimes as an antimicrobial polymer additive. Further, triclosan rapid alternating ether bond rotations disrupt secondary bonding between chain monomers in the resin state to reduce viscosity and enhance polymer blending. Thus, triclosan is considered for a polymer additive with multiple properties to be an antimicrobial with additional benefits as a nonpolar toughening agent and a hydrophobic wetting agent. The triclosan material relationships with alternating ether bond rotations are described through a complete different form of medium by comparisons with known antimicrobial properties that upset bacterial cell membranes through rapid fluctuating mechanomolecular energies. Also, triclosan bond entanglements with secondary bonding can produce structural defects in weak bacterial lipid membranes requiring pliability that can then interfere with cell division. Regarding applications with polymers, triclosan can be incorporated by mixing into a resin system before cure, melt mixed with thermoplastic polymers that set on cooling

  7. Ecological and environmental data as under-utilized national resources: results of the TIE/ACCESS program

    Energy Technology Data Exchange (ETDEWEB)

    Armentano, T.V.; Loucks, O.L.

    1979-06-01

    The goal of The Institute of Energy (TIE) 1977 to 1979 ACCESS program was to define the national need for ecological and environmental data and the extent to which present data documentation and archiving are meeting this need. The principal steps focussed on current data documentation and research in government, private and academic sectors of the natural science technical community, particularly as they bear on the accessibility of environmental data to secondary users. The extent to which existing data services are satisfying the needs of data users also was emphasized. The results indicate that the potential contributions which existing data and models could make are not being achieved because of inconsistencies in data documentation, inadequate communication between data suppliers and data users, and a lack of overall coordination of the data bases in national research and monitoring programs. A nationally coordinated network is proposed which focuses on regional data centers and ties together the hierarchy of data bases (national, state, and local) with the broad spectrum of potential users. The network concept includes immediate development of a comprehensive catalog of data resources in each region, with later production of a data abstract journal as one of two methods for communicating between regional and local data centers and the user community.

  8. Market research for electric utilities

    International Nuclear Information System (INIS)

    Marketing research is increasing in importance as utilities become more marketing oriented. Marketing research managers need to maintain autonomy from the marketing director or ad agency and make sure their work is relevant to the utility's operation. This article will outline a model marketing research program for an electric utility. While a utility may not conduct each and every type of research described, the programs presented offer a smorgasbord of activities which successful electric utility marketers often use or have access to

  9. Utilization of the equipment and program cine- and telerecording complex for the high-frequency steel pipe welding investigation

    Science.gov (United States)

    Konovalov, Nikolai A.; Veselovsky, Vladimir B.; Furmanov, Valeri B.; Kovalenko, Vladimir I.; Lakhno, Nikolay I.; Kovika, Nikolai D.; Novikov, Leonid V.; Scherbina, Vadim N.; Zlydennaya, Lyubov M.

    1995-08-01

    With the aim of technological process automatization and control for high-frequency welding of different diameter pipes, the machine-program complex (APC) was designed. APC gives the opportunity to create the cine- and telerecording of process in production conditions at the mill '159-529' of the Novomoskovsky Tube Rolling Mill, Ukraine). With the help of APC in real functioning mill conditions, the character of flashing zone length changing and the angle of convergence depending on pipe welding speed was investigated. Also the zone of jumpers is defined. The comparison of theoretical and experimental data gave an opportunity to define a welding rate which is optimal for the most qualitative values of welded joints in the range of pipe products of mill '159-529'.

  10. Antimicrobial stewardship: a matter of process or outcome?

    Science.gov (United States)

    Khadem, Tina M; Dodds Ashley, Elizabeth; Wrobel, Mark J; Brown, Jack

    2012-08-01

    The risk of antimicrobial resistance and superinfection is increasing alongside rates of hospital-acquired infection. Imprudent antibiotic use combined with few novel antimicrobials can speed resistance. Antimicrobial stewardship programs (ASPs) advocate for judicious use of available antimicrobials to preserve their usefulness. Decreased antibiotic expenditures was the backbone of early justification for ASPs, but the function of these programs has evolved into measuring the quality and appropriateness of antimicrobial use. Proper evaluation of an ASP helps to inform which methods work best for a particular institution and can help to define best practices at a more global level. Study design and duration limitations, however, can make it difficult to measure the impact of these programs. Process measures have been validated and can evaluate quality of care; however, they do not adequately describe the clinical impact of these programs at the patient level. Outcome measures also have limitations; they are not a direct measure of quality of care. Therefore, both process and outcome measures need to be defined and assessed when evaluating an ASP to confirm that goals of the intervention are attained and clinical objectives are met. Most available well-designed studies judging the effectiveness of ASPs use process measures alone. Adding improvements in clinical outcomes to process measures would theoretically attract the attention of a broader audience and provide additional support to expand current ASPs and develop novel ASPs.

  11. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in the United States. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.; Gallagher, K.C.; Hejna, D.; Rielley, K.J.

    1980-01-01

    This report is a summary of a series of preliminary reports describing the laws and regulatory programs of the United states and each of the 50 states affecting the siting and operation of energy generating facilities likely to be used in Integrated Community Energy Systems (ICES). A brief summary of public utility regulatory programs, energy facility siting programs, and municipal franchising authority is presented in this report to identify how such programs and authority may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES. Subsequent reports will (1) describe public utility rate regulatory procedures and practices as they might affect an ICES, (2) analyze each of the aforementioned regulatory programs to identify impediments to the development of ICES, and (3) recommend potential changes in legislation and regulatory practices and procedures to overcome such impediments.

  12. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in New Hampshire. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    Public utilities in New Hampshire are regulated by the Public Utilities Commission. The Commission is comprised of three members appointed for six-year terms by the Governor with the advice and consent of the council. Members of the Commission must be free from any employment or pecuniary interests in any public utility. The Commission is charged with the general regulation and supervision of public utilities. Within the purview of its powers, the authority of the Commission supercedes that of local government. The Commission may suspend the operation of local zoning laws. Local governments do retain the right to license the use of public ways by utilities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  13. Hazelwood Interim Storage Site, Hazelwood, Missouri: Annual site environmental report, Calendar year 1987: Formerly Utilized Sites Remedial Action Program (FUSRAP)

    International Nuclear Information System (INIS)

    The monitoring program at the HISS measures radon concentrations in air; external gamma radiation levels; and uranium, radium, and thorium concentrations in surface water, groundwater, and sediment. To verify that the site is in compliance with the DOE radiation protection standard (100 mrem/yr) and assess its potential effect on public health, the radiation dose was calculated for the maximally exposed individual. Based on the scenario described in this report, the maximally exposed individual at the HISS would receive an annual external exposure approximately equivalent to 1 percent of the DOE radiation protection standard of 100 mrem/yr. This exposure is less than the exposure a person would receive during a round-trip flight from New York to Los Angeles (because of the greater amounts of cosmic radiation at higher altitudes). The cumulative dose to the population within an 80-km (50-mi) radius of the HISS that would result from radioactive materials present at the site would be indistinguishable from the dose that the same population would receive from naturally occurring radioactive sources. The results of 1987 monitoring show that the HISS is in compliance with the DOE radiation protection standard. 12 refs., 6 figs., 11 tabs

  14. PRO/Mapper: a plotting program for the DEC PRO/300 personal computers utilizing the MAPPER graphics language

    International Nuclear Information System (INIS)

    PRO/Mapper is an application for the Digital Equipment Corporation PRO/300 series of personal computers that facilitates the preparation of visuals such as graphs, charts, and maps in color or black and white. The user prepares an input data file containing English-language commands and writes it into a file using standard editor. PRO/Mapper then reads these files and draws graphs, maps, boxes, and complex line segments onto the computer screen. Axes, curves, and error bars may be plotted in graphical presentations. The commands of PRO/Mapper are a subset of the commands of the more sophisticated MAPPER program written for mainframe computers. The PRO/Mapper commands were chosen primarily for the production of linear graphs. Command files written for the PRO/300 are upward compatible with the Martin Marietta Energy Systems version of MAPPER and can be used to produce publication-quality slides, drawings, and maps on the various output devices of the Oak Ridge National Laboratory mainframe computers

  15. Antimicrobial peptides in Echinoderms

    Directory of Open Access Journals (Sweden)

    C Li

    2010-05-01

    Full Text Available Antimicrobial peptides (AMPs are important immune effector molecules for invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system. Here we summarize the knowledge of such peptides in echinoderms. Strongylocins are a novel family of cysteine-rich AMPs, recently identified in the sea urchins, Strongylocentrotus droebachiensis and S. purpuratus. Although these molecules present diverse amino acid sequences, they share an identical cysteine arrangement pattern, dissimilar to other known AMPs. A family of heterodimeric AMPs, named centrocins, are also present in S. droebachiensis. Lysozymes and fragments of larger proteins, such as beta-thymocins, actin, histone 2A and filamin A have also been shown to display antimicrobial activities in echinoderms. Future studies on AMPs should be aimed in revealing how echinoderms use these AMPs in the immune response against microbial pathogens.

  16. [Neruda and antimicrobial resistance].

    Science.gov (United States)

    Cotera, Alejandro

    2011-07-01

    Antimicrobial resistance has been a problem in medicine, since their incorporation to clinical practice. Numerous papers have been written on the subject. The analysis of two poems by Pablo Neruda "How much does a man live" and "Larynx", included in the volume "Estravagario" and published for the first time in 1957 and 1958, give us an incredible revelation about the concept of resistance. In these poems aureomycin, the first antimicrobial of the family of tetracyclines, was included as a poetic figure and the therapeutic action of antimicrobials was described. "Never so much bugs died I tons of them fell I but the few that remained olive I manifested their perversity". These writings incorporated novel concepts, even for physicians of that time and described the closeness of death that a patient may perceive during the course of a given disease. The capacity of Pablo Neruda to extract the essence of situations and to anticipate to conditions that only years later became clinically relevant problems, is noteworthy.

  17. Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing.

    Science.gov (United States)

    Mi, Hongfei; Wang, Dai; Xue, Yunxin; Zhang, Zhi; Niu, Jianjun; Hong, Yuzhi; Drlica, Karl; Zhao, Xilin

    2016-08-01

    The contribution of reactive oxygen species (ROS) to antimicrobial lethality was examined by treating Escherichia coli with dimethyl sulfoxide (DMSO), an antioxidant solvent frequently used in antimicrobial studies. DMSO inhibited killing by ampicillin, kanamycin, and two quinolones and had little effect on MICs. DMSO-mediated protection correlated with decreased ROS accumulation and provided evidence for ROS-mediated programmed cell death. These data support the contribution of ROS to antimicrobial lethality and suggest caution when using DMSO-dissolved antimicrobials for short-time killing assays. PMID:27246776

  18. Middlesex Sampling Plant environmental report for calendar year 1992, 239 Mountain Avenue, Middlesex, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    This report describes the environmental surveillance program at the Middlesex Sampling Plant (MSP) and provides the results for 1992. The site, in the Borough of Middlesex, New Jersey, is a fenced area and includes four buildings and two storage piles that contain 50,800 m{sup 3} of radioactive and mixed hazardous waste. More than 70 percent of the MSP site is paved with asphalt. The MSP facility was established in 1943 by the Manhattan Engineer District (MED) to sample, store, and/or ship uranium, thorium, and beryllium ores. In 1955 the Atomic Energy Commission (AEC), successor to MED, terminated the operation and later used the site for storage and limited sampling of thorium residues. In 1967 AEC activities ceased, onsite structures were decontaminated, and the site was certified for unrestricted use under criteria applicable at that time. In 1980 the US Department of Energy (DOE) initiated a multiphase remedial action project to clean up several vicinity properties onto which contamination from the plant had migrated. Material from these properties was consolidated into the storage piles onsite. Environmental surveillance of MSP began in 1980 when Congress added the site to DOE`s Formerly Utilized Sites Remedial Action Program. The environmental surveillance program at MSP includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-230, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analyses are performed to detect metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling th DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses.

  19. NASA's Orbital Debris Optical and IR Ground-Based Observing Program Utilizing the MCAT, UKIRT, and Magellan Telescopes

    Science.gov (United States)

    Lederer, Susan; Cowardin, H. M.; Buckalew, B.; Frith, J.; Hickson, P.; Pace, L.; Matney, M.; Anz-Meador, P.; Seitzer, P.; Stansbery, E.; Glesne, T.

    2016-01-01

    Characterizing debris in Earth-orbit has become increasingly important as the population growth rises steadily, posing greater and greater threats to active satellites with each passing year. Currently, the Joint Space Operations is tracking over 23,000 pieces of debris, ranging in size from 1-meter and larger in geosychronous orbits (GEO) to 10-cm and larger at low-Earth orbits (LEO). Model estimates suggest that there may be more than 500,000 pieces of spacecraft debris larger than 1 cm currently in orbit around the Earth. With such a small fraction of the total population being tracked, and new break-ups occurring in LEO, GEO, and Geo Transfer Orbits, new assets, techniques, and approaches for characterizing this debris are needed. With this in mind, NASA's Orbital Debris Program Office has actively tasked a suite of telescopes around the world. In 2015, the newly-built 1.3m optical Meter Class Autonomous Telescope (MCAT) came on-line on Ascension Island in the South Atlantic Ocean and is currently in its commissioning phase. MCAT is designed to track Earth-orbiting objects above 200km, conduct surveys at GEO, and work in tandem with a newly-installed Raven-class commercial-off-the-shelf system, a 0.4-meter telescope co-located on Ascension with a field-of-view similar to MCAT's and research-grade instrumentation designed to complement MCAT for observations taken either simultaneously or in tandem. The 3.8m infrared UKIRT telescope on Mauna Kea, Hawaii, has been heavily tasked throughout 2015 and into 2016, collecting data on individual targets as well as in survey modes to study both the general GEO population as well as an individual break-up event of a BRIZ-M Rocket body that occurred in January 2016. Data collected include photometry and spectroscopy in the near-Infrared (0.85-2.5 m) and the mid-infrared (8-16 m). Finally, the 6.5-m Baade Magellan telescope at Las Campanas Observatory in Chile was used to collect optical photometric survey data in October

  20. Phytochemical and Antimicrobial Studies of Chlorophytum borivilianum

    Directory of Open Access Journals (Sweden)

    Guno Sindhu Chakraborthy

    2009-07-01

    Full Text Available Extracts of leaves and stems of Chlorophytum borivilianum were subjected to preliminary phytochemical screening and in-vitro antimicrobial studies. The results of the preliminary investigation revealed the presence of alkaloids, glycosides, steroidal nucleus, saponins and tannins in both parts. The methanolic extract of leaf and stems part were investigated for antimicrobial activity using agar disc diffusion method. Six clinical strains of human pathogenic microorganisms, comprising 3 Gram +ve, 1 Gram -ve and 2 fungi were utilized in the studies. The leaf extract of Chlorophytum borivilianum displayed overwhelming concentration dependent antimicrobial properties, inhibiting the growth of Staphylococcus aureus and Bacillus cereus, far above that of ampicillin used in a concentration of 1.0 g/ml. The extract was less sensitive to 2 Gram -ve bacteria in the assay. In antifungal assay, the growth of Aspergillus niger and Candida albicans, were inhibited in the same manner comparable to voriconazole the reference drug used in the study. The methanol extract of stem also displayed a concentration related antibacterial activity, inhibiting the growth of S. aureus comparable to ampicillin at 1.0 g/ml. The extract was least active against Escherichia coli with a mild activity at 1.0 g/ml. The extract exhibited weak activities against C. albicans as well as A. niger. Both plant parts seem to justify their ethno medical uses.

  1. Fall Protection Procedures for Sealing Bulk Waste Shipments by Rail Cars at Formerly Utilized Sites Remedial Action Program (FUSRAP) Sites - 13509

    International Nuclear Information System (INIS)

    Rail-cars loaded with radioactive materials must be closed and fastened to comply with United States Department of Transportation (DOT) requirements before they shipped. Securing waste shipments in a manner that meets these regulations typically results in the use of a sealable rail-car liner. Workers accessing the tops of the 2.74 m high rail-cars to seal and inspect liners for compliance prior to shipment may be exposed to a fall hazard. Relatively recent revisions to the Fall Protection requirements in the Safety and Health Requirements Manual (EM385-1-1, U.S. Army Corps of Engineers) have necessitated modifications to the fall protection systems previously employed for rail-car loading at Formerly Utilized Sites Remedial Action Program (FUSRAP) sites. In response these projects have developed site-specific procedures to protect workers and maintain compliance with the improved fall protection regulations. (authors)

  2. Antimicrobial Drugs in the Home

    Centers for Disease Control (CDC) Podcasts

    2006-10-19

    Survey participants in the United Kingdom admitted keeping leftover antimicrobial drugs for future use and taking them without medical advice. Dr. J. Todd Weber, director of CDC's Office of Antimicrobial Resistance, advises against the practice, which can be dangerous and can promote antimicrobial drug resistance.  Created: 10/19/2006 by Emerging Infectious Diseases.   Date Released: 10/26/2006.

  3. A database for the program 'Environmentally correct utilization of ashes'; Databas inom delprogrammet 'Miljoeriktig anvaendning av askor'

    Energy Technology Data Exchange (ETDEWEB)

    Bjurstroem, Henrik; Rydstrand, Camilla; Berg, Magnus; Wikman, Karin [AaF-Energi and Miljoe AB, Stockholm (Sweden)

    2004-01-01

    In the program 'Environmentally correct utilization of ashes' that is active 2002-2005 at the Swedish Thermal Research Institute (Vaermeforsk), R and D studies of the properties of ashes or combustion residues are being carried out and will be carried out. It may be difficult to obtain an overview of these data if these are dispersed in a large number of reports. These data are valuable as they may be used as references on the properties of ashes (these do vary widely, and knowledge of the range within which they vary as well of as the cause to effect chain is far from exhaustive). They also form a basis for continued work in this area. Furthermore, one of the aims of the R and D program is to define criteria for the use of ashes in various situations. Such criteria are generally formulated using quantitative requirements on technical as well as environmental properties. A flexible database has been created in Access in order to store these data on ashes as an easy-to-access reference. The goal was satisfaction of both a user of ashes and a producer of ashes. The information that can be stored stretches from the fuel, the design of the combustion plant to properties specific to a given utilization such as shear module or permeability. Attention has especially been paid to the facts that fuels are often mixed and that ashes are often mixed with other ashes or with other materials. In this first stage, data have been stored in the database for 22 ash samples that have been studied in eight R and D projects.

  4. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in the United States. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.; Gallagher, K.C.; Hejna, D.; Rielley, K.J.

    1980-01-01

    This report is one of a series of preliminary reports describing the laws and regulatory programs of the United States and each of the 50 states affecting the siting and operation of energy generating facilities likely to be used in Integrated Community Energy Systems (ICES). Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES. This report describes laws and regulatory programs in the United States. Subsequent reports will (1) describe public utility rate regulatory procedures and practices as they might affect an ICES, (2) analyze each of the aforementioned regulatory programs to identify impediments to the development of ICES, and (3) recommend potential changes in legislation and regulatory practices and procedures to overcome such impediments.

  5. The interactive web-based program MSmonitor for self-management and multidisciplinary care in multiple sclerosis: utilization and valuation by patients

    Directory of Open Access Journals (Sweden)

    Jongen PJ

    2016-03-01

    Full Text Available Peter Joseph Jongen,1,2 Ludovicus G Sinnige,3 Björn M van Geel,4 Freek Verheul,5 Wim I Verhagen,6 Ruud A van der Kruijk,7 Reinoud Haverkamp,8 Hans M Schrijver,9 Jacoba C Baart,10 Leo H Visser,11 Edo P Arnoldus,12 Herman Jacobus Gilhuis,13 Paul Pop,14 Monique Booy,15 Marco Heerings,16 Anton Kool,17 Esther van Noort17 1Department of Community and Occupational Medicine, University Medical Center Groningen, University of Groningen, Groningen, 2MS4 Research Institute, Nijmegen, 3Multiple Sclerosis Centre Leeuwarden, Medical Centre Leeuwarden, Leeuwarden, 4Department of Neurology, Medical Centre Alkmaar, Alkmaar, 5Department of Neurology, Groene Hart Hospital, Gouda, 6Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, 7Department of Neurology, Slingeland Hospital, Doetinchem, 8Department of Neurology, Zuwe Hofpoort Hospital, Woerden, 9Multiple Sclerosis Centre, Westfries Gasthuis, Hoorn, 10Department of Neurology, Ziekenhuisgroep Twente, Almelo-Hengelo, 11Multiple Sclerosis Centre Midden Brabant, St Elisabeth Hospital, Tilburg, 12Multiple Sclerosis Centre Midden Brabant, Tweesteden Hospital, 13Department of Neurology, Reinier de Graaf Gasthuis, Delft, 14Department of Neurology, Viecuri Medical Centre, Venlo-Venray, 15Multiple Sclerosis Centre, Amphia Hospital, Breda, 16MH Advies en organisatiebureau, Assen, 17Curavista bv, Geertruidenberg, the Netherlands Background: MSmonitor is an interactive web-based program for self-management and integrated, multidisciplinary care in multiple sclerosis.Methods: To assess the utilization and valuation by persons with multiple sclerosis, we held an online survey among those who had used the program for at least 1 year. We evaluated the utilization and meaningfulness of the program’s elements, perceived use of data by neurologists and nurses, and appreciation of care, self-management, and satisfaction.Results: Fifty-five persons completed the questionnaire (estimated response rate 40%. The

  6. Performance of the FilmArray® blood culture identification panel utilized by non-expert staff compared with conventional microbial identification and antimicrobial resistance gene detection from positive blood cultures.

    Science.gov (United States)

    McCoy, Morgan H; Relich, Ryan F; Davis, Thomas E; Schmitt, Bryan H

    2016-07-01

    Utilization of commercially available rapid platforms for microbial identification from positive blood cultures is useful during periods of, or in laboratories with, limited expert staffing. We compared the results of the FilmArray® BCID Panel performed by non-expert technologists to those of conventional methods for organism identification performed by skilled microbiologists. Within 8 h of signalling positive by a continuous monitoring blood culture system, positive bottles were analysed by the FilmArray BCID Panel. Data from these analyses were compared to standard-of-care testing, which included conventional and automated methods. To gauge the ease of use of the BCID Panel by non-expert staff, technologists unfamiliar with diagnostic bacteriology performed the testing without prior knowledge of the Gram stain results, or even whether organisms were detected. Identifications of 172/200 (86 %) positive blood cultures using the BCID Panel were consistent with identifications provided by standard-of-care methods. Standard-of-care testing identified organisms in 20 positive blood cultures, which were not represented on the BCID Panel. Seven (3.5 %) blood cultures demonstrated a discrepancy between the methods, which could not be attributed to either a lack of representation on the panel or unclear separate detection of organisms in a mixed blood culture of a shared genus or grouping of organisms, e.g. Staphylococcus or Enterobacteriaceae . One (0.5 %) blood culture yielded invalid results on two separate panels, so it was eliminated from the study. The easy-to-use FilmArray® technology shows good correlation with blood culture identification and antibiotic resistance detection performed by conventional methods. This technology may be particularly useful in laboratories with limited staffing or limited technical expertise. PMID:27170288

  7. Performance of the FilmArray® blood culture identification panel utilized by non-expert staff compared with conventional microbial identification and antimicrobial resistance gene detection from positive blood cultures.

    Science.gov (United States)

    McCoy, Morgan H; Relich, Ryan F; Davis, Thomas E; Schmitt, Bryan H

    2016-07-01

    Utilization of commercially available rapid platforms for microbial identification from positive blood cultures is useful during periods of, or in laboratories with, limited expert staffing. We compared the results of the FilmArray® BCID Panel performed by non-expert technologists to those of conventional methods for organism identification performed by skilled microbiologists. Within 8 h of signalling positive by a continuous monitoring blood culture system, positive bottles were analysed by the FilmArray BCID Panel. Data from these analyses were compared to standard-of-care testing, which included conventional and automated methods. To gauge the ease of use of the BCID Panel by non-expert staff, technologists unfamiliar with diagnostic bacteriology performed the testing without prior knowledge of the Gram stain results, or even whether organisms were detected. Identifications of 172/200 (86 %) positive blood cultures using the BCID Panel were consistent with identifications provided by standard-of-care methods. Standard-of-care testing identified organisms in 20 positive blood cultures, which were not represented on the BCID Panel. Seven (3.5 %) blood cultures demonstrated a discrepancy between the methods, which could not be attributed to either a lack of representation on the panel or unclear separate detection of organisms in a mixed blood culture of a shared genus or grouping of organisms, e.g. Staphylococcus or Enterobacteriaceae . One (0.5 %) blood culture yielded invalid results on two separate panels, so it was eliminated from the study. The easy-to-use FilmArray® technology shows good correlation with blood culture identification and antibiotic resistance detection performed by conventional methods. This technology may be particularly useful in laboratories with limited staffing or limited technical expertise.

  8. Does variation among provincial drug formulary antimicrobial listings in Canada influence prescribing rates?

    Directory of Open Access Journals (Sweden)

    Shiona K Glass-Kaastra

    Full Text Available BACKGROUND: The financial accessibility of antimicrobial drugs to the outpatient community in Canada is governed at the provincial level through formularies. Each province may choose to list particular drugs or impose restriction criteria on products in order to guide prescribing and/or curtail costs. Although changes to formularies have been shown to change patterns in the use of individual products and alter costs, no comparison has been made among the provincial antimicrobial formularies with regards to flexibility/stringency, or an assessment of how these formularies impact overall antimicrobial use in the provinces. OBJECTIVES: To summarize provincial antimicrobial formularies and assess whether their relative flexibility/stringency had a statistical impact upon provincial prescription volume during a one year period. METHODS: Provincial drug plan formularies were accessed and summarized for all prescribed antimicrobials in Canada during 2010. The number of general and restricted benefits for each plan was compiled by antimicrobial classification. Population-adjusted prescription rates for all individual antimicrobials and by antimicrobial class were obtained from the Canadian Integrated Program for Antimicrobial Resistance Surveillance. Correlations between the number of general benefits, restricted benefits, and total benefits with the prescription rate in the provinces were assessed by Spearman rank correlation coefficients. RESULTS: Formularies varied considerably among the Canadian provinces. Quebec had the most flexible formulary, offering the greatest number of general benefits and fewest restrictions. In contrast, Saskatchewan's formulary displayed the lowest number of general benefits and most restrictions. Correlation analyses detected a single significant result; macrolide prescription rates decreased as the number of general macrolide benefits increased. All other rates of provincial antimicrobial prescribing and measures of

  9. Programs.

    Science.gov (United States)

    Community College Journal, 1996

    1996-01-01

    Includes a collection of eight short articles describing model community college programs. Discusses a literacy program, a mobile computer classroom, a support program for at-risk students, a timber-harvesting program, a multimedia presentation on successful women graduates, a career center, a collaboration with NASA, and an Israeli engineering…

  10. Connecting Hispanic Women in Baltimore to the Mercy Medical Center Sexual Assault Forensic Examiners/Forensic Nurse Examiners Program: A Preliminary Assessment of Service Utilization and Community Awareness.

    Science.gov (United States)

    Adams, Margaret; Fitzgerald, Sheila; Holbrook, Debra

    2016-01-01

    Sexual violence and gender-based violence represent a major public health problem causing significant negative mental, physical, and social outcomes for victims. The rapidly growing population of Hispanic women in Baltimore are both more vulnerable to sexual assault and less able to access postassault services. In an effort to assess service utilization and community awareness of the Mercy Medical Center Sexual Assault Forensic Examiners/Forensic Nurse Examiners Program, we conducted a retrospective chart review of 2,322 women who were seen by the program between 2010 and 2013 and found that only 2.5% of the women were identified as Hispanic, about half of what Baltimore City demographic data would predict. This exploratory pilot project, augmented by key informant interviews, reveals that Hispanic women are underutilizing sexual assault services. Multiple barriers exist for Hispanic women in obtaining victim services, including lack of awareness within the community that the services exist, cultural factors, language barriers, lack of awareness of legal rights, and a fear of deportation. PMID:27428791

  11. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Oregon. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Public Utility Commissioner of Oregon. The Commissioner is appointed by the governor, subject to confirmation by the senate, for a term of four years. He must be free of any pecuniary or employment interest in any business subject to the jurisdiction of the Commissioner. While the Commissioner is primarily responsible for regulating public utilities, local governments do retain some control over utility operations within municipal boundaries. A local government may determine by contract or prescribe by ordinance the quality and character of service furnished by a public utility and may control the use of streets and other public property by public utilities. Municipalities may require public utilities to make any modifications, additions, or extensions to facilities as are necessary to the public interest. In addition, local governments may fix, by contract or ordinance, the rates to be charged by public utilities furnishing service within a municipality. The Commissioner, however, has the power to review any of the above-described local actions. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  12. Antimicrobial susceptibilities of Clostridium difficile.

    OpenAIRE

    Shuttleworth, R; Taylor, M.; Jones, D M

    1980-01-01

    The antimicrobial susceptibilities of 78 strains of Clostridium difficile isolated from patients with and without gastrointestinal symptoms were determined and compared. Strains from patients with symptoms were more likely to show resistance to antibiotics. The antimicrobial susceptibilities of toxigenic and non-toxigenic strains were found to be similar.

  13. Engineering Antimicrobials Refractory to Resistance

    Science.gov (United States)

    Multi-drug resistant superbugs are a persistent problem in modern health care, demonstrating the need for a new class of antimicrobials that can address this concern. Triple-acting peptidoglycan hydrolase fusions are a novel class of antimicrobials which have qualities well suited to avoiding resis...

  14. Flame Retardant and Antimicrobial Jute Textile Using Sodium Metasilicate Nonahydrate

    Directory of Open Access Journals (Sweden)

    Basak S.

    2014-06-01

    Full Text Available Flame retardant and antimicrobial functionalities were imparted in jute textile using sodium metasilicate nonahydrate (SMSN, commonly known as “water glass”. Sodium metasilicate nonahydrate (SMSN was applied in jute fabric in different concentration by padding method followed by drying. Flame retardancy of the fabric was evaluated by Limiting Oxygen Index (LOI and burning behaviour under vertical flammability tester including the char length. Burning rate was found to decrease by almost 10 times after an application of 2% SMSN compared to the control sample. Thermogravimetry (TG and differential scanning calorimetry (DSC analysis of both the control and treated jute fabrics were utilized to understand the mechanism of developed flame retardance in jute fabric. It was observed that the SMSN treated samples showed excellent antimicrobial property against both gram positive and gram negative bacteria. Antimicrobial properties of both the control and treated jute fabrics were also measured quantitatively.

  15. How to fight antimicrobial resistance.

    Science.gov (United States)

    Foucault, Cédric; Brouqui, Philippe

    2007-03-01

    Antimicrobial misuse results in the development of resistance and superbugs. Over recent decades, resistance has been increasing despite continuing efforts to control it, resulting in increased mortality and cost. Many authorities have proposed local, regional and national guidelines to fight against this phenomenon, and the usefulness of these programmes has been evaluated. Multifaceted intervention seems to be the most efficient method to control antimicrobial resistance. Monitoring of bacterial resistance and antibiotic use is essential, and the methodology has now been homogenized. The implementation of guidelines and infection control measures does not control antimicrobial resistance and needs to be reinforced by associated measures. Educational programmes and rotation policies have not been evaluated sufficiently in the literature. Combination antimicrobial therapy is inefficient in controlling antimicrobial resistance.

  16. Antimicrobial activity of antiproteinases.

    Science.gov (United States)

    Sallenave, J M

    2002-04-01

    Low-molecular-mass neutrophil elastase inhibitors have been shown to be important in the control of lung inflammation. In addition to inhibiting the enzyme neutrophil elastase, these low-molecular-mass compounds (10 kDa) have been shown to have other activities. For example, secretory leucocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor/SKALP (skin-derived antileucoproteinase)/elafin have also been shown to have "defensin"-like antimicrobial activities. Indeed, these inhibitors have antimicrobial properties in vitro against bacteria, fungi and, potentially, HIV. In addition, we have shown, using an adenovirus-mediated gene transfer overexpression strategy, that elafin is also active against Pseudomonas aeruginosa infection in mice in vivo. The mechanism of action is currently under investigation. In addition to these direct or indirect effects on microbes, it has been shown that lipopolysaccharide is able to up-regulate SPLI production in macrophages in vitro, and that the addition of recombinant SLPI to human monocytes or the transfection of macrophages with SPLI can down-regulate pro-inflammatory mediators such as tumour necrosis factor, presumably to limit self-damaging excessive inflammation. Using viral gene transfer vectors, we are currently investigating the potential of these inhibitors in various models of inflammation in vivo. PMID:12023836

  17. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in South Carolina. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    Pursuant to constitutional South Carolina mandate the General Assembly has created the Public Service Commission. The Commission is composed of seven members elected to four year terms by the General Assembly. One commissioner is elected from each of seven districts corresponding to the congressional districts as they existed as of January 1, 1930. The commissioners elect one of their members as chairman. The South Carolina statutes contain separate chapters dealing with the regulation of public utilities and electric utilities. Public utility includes the furnishing of gas or heat (other than by means of electricity) to the public. While the Commission is granted general supervisory and regulatory powers over public utilities and electric utilities, total governments retain some control over electrical utilities. All municipality's have the power to grant exclusive franchises to such utilities for the furnishing of light to the municipality and its inhabitants. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  18. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Rhode Island. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The Rhode Island statutes vest in the Public Utility Commission and the Division of Public Utilities the exclusive power and authority to regulate public utility companies in that state. Both bodies have been established within the Department of Business Regulation but are independent of the Department's director and are not under his jurisdiction. The jurisdiction to regulate utilities is shared by the Commission and the Division. The Commission serves as a quasi-judicial tribunal with jurisdiction, powers, and duties to hold investigations and hearings involving rates, sufficiency and resonableness of facilities, gas, electric, water, and pipeline public utilities. The administrator, who is chief executive officer of the Division, is responsible for exercising the jurisdiction, supervision, powers, and duties not specifically assigned to the Commission. By virtue of his office, the chairman of the Commission serves also as the administrator and he supervises and directs the execution of all laws relating to public utilities and carriers and all regulations and orders of the Commission governing the conduct and charges of public utilities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  19. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in North Carolina. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    Under the Public Utilities Act of 1965, utilities in North Carolina are regulated by the State's Utility Commission. The Commission consists of seven members who are appointed by the governor, subject to confirmation by the General Assembly sitting in joint session. The Commissioners serve eight year terms and the governor designates one of the commissioners as chairman. The Commission has an office of the executive director, who is appointed to a six year term by the governor subject to confirmaion by the General Assembly. The executive director heads the Commission's public staff. The public staff's duties include reviewing, investigating, and making recommendations on utility rates and services and intervention on behalf of the public in proceedings affecting consumer rates and generating plant certification. The Commission has the same power to regulate the operation of privately-owned public utilities within municipalities as it has to control those ouside. The only power over privately-owned utilities reserved to the municipalities is the power to grant franchises. A municipality may maintain its own utility systems, and such systems are not subject to the control and jurisdiction of the Commission. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  20. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Delaware. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D.A.; Weaver, C.L.; Gallagher, K.C.; Hejna, D.; Rielley, K.J.

    1980-01-01

    The regulation of public utilities in Delaware is the responsibility of the Public Service Commission (PSC). The PSC consists of five commissioners appointed by the governor and confirmed by a majority of the senate for terms of five years each. Not more than three members are to be from the same political party. One member is to be a resident of Kent County, one of Sussex County, one of the City of Wilmington, and two members are to be of New Castle County outside of Wilmington. Local governments retain control over the rates, property, equipment, facilities, and franchises of municipally owned utilities. Such utilities are expressly exempted from PSC regulation. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  1. Evaluation of Final Radiological Conditions at Areas of the Niagara Falls Storage Site Remediated under the Formerly Utilized Sites Remedial Action Program -12184

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Christopher [U.S Department of Energy Office of Legacy Management, Washington, DC; Kothari, Vijendra [U.S Department of Energy Office of Legacy Management, Morgantown, West Virginia; Starr, Ken [U.S Department of Energy Office of Legacy Management, Westminster, Colorado; Widdop, Michael; Gillespie, Joey [SM Stoller Corporation, Grand Junction, Colorado

    2012-02-26

    The U. S. Department of Energy (DOE) methods and protocols allow evaluation of remediation and final site conditions to determine if remediated sites remain protective. Two case studies are presented that involve the Niagara Falls Storage Site (NFSS) and associated vicinity properties (VPs), which are being remediated under the Formerly Utilized Sites Remedial Action Program (FUSRAP). These properties are a part of the former Lake Ontario Ordnance Works (LOOW). In response to stakeholders concerns about whether certain remediated NFSS VPs were putting them at risk, DOE met with stakeholders and agreed to evaluate protectiveness. Documentation in the DOE records collection adequately described assessed and final radiological conditions at the completed VPs. All FUSRAP wastes at the completed sites were cleaned up to meet DOE guidelines for unrestricted use. DOE compiled the results of the investigation in a report that was released for public comment. In conducting the review of site conditions, DOE found that stakeholders were also concerned about waste from the Separations Process Research Unit (SPRU) at the Knolls Atomic Power Laboratory (KAPL) that was handled at LOOW. DOE agreed to determine if SPRU waste remained at that needed to be remediated. DOE reviewed records of waste characterization, historical handling locations and methods, and assessment and remediation data. DOE concluded that the SPRU waste was remediated on the LOOW to levels that pose no unacceptable risk and allow unrestricted use and unlimited exposure. This work confirms the following points as tenets of an effective long-term surveillance and maintenance (LTS&M) program: Stakeholder interaction must be open and transparent, and DOE must respond promptly to stakeholder concerns. DOE, as the long-term custodian, must collect and preserve site records in order to demonstrate that remediated sites pose no unacceptable risk. DOE must continue to maintain constructive relationships with the U

  2. Antimicrobial resistance of zoonotic and commensal bacteria in Europe: the missing link between consumption and resistance in veterinary medicine.

    Science.gov (United States)

    Garcia-Migura, Lourdes; Hendriksen, Rene S; Fraile, Lorenzo; Aarestrup, Frank M

    2014-05-14

    The emergence of resistance in food animals has been associated to the consumption of antimicrobials in veterinary medicine. Consequently, monitoring programs have been designed to monitor the occurrence of antimicrobial resistant bacteria. This study analyses the amount of antimicrobial agents used in nine European countries from 2005 to 2011, and compares by univariate analysis the correlations between consumptions of each of the following antimicrobial classes; tetracycline, penicillins, cephalosporins, quinolones and macrolides. An overview of resistance in zoonotic and commensal bacteria in Europe focusing on Salmonella, Escherichia coli, Campylobacter sp. and Enterococcus sp., during the same period of time based on monitoring programs is also assessed. With the exception of cephalosporins, linear regressions showed strong positive associations between the consumption of the four different antimicrobial classes. Substantial differences between countries were observed in the amount of antimicrobials used to produce 1 kg of meat. Moreover, large variations in proportions of resistant bacteria were reported by the different countries, suggesting differences in veterinary practice. Despite the withdrawn of a specific antimicrobial from "on farm" use, persistence over the years of bacteria resistant to this particular antimicrobial agent, was still observed. There were also differences in trends of resistance associated to specific animal species. In order to correlate the use of antimicrobial agents to the presence of resistance, surveillance of antimicrobial consumption by animal species should be established. Subsequently, intervention strategies could be designed to minimize the occurrence of resistance.

  3. Novel Formulations for Antimicrobial Peptides

    Directory of Open Access Journals (Sweden)

    Ana Maria Carmona-Ribeiro

    2014-10-01

    Full Text Available Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy.

  4. [Antimicrobial susceptibility in Chile 2012].

    Science.gov (United States)

    Cifuentes-D, Marcela; Silva, Francisco; García, Patricia; Bello, Helia; Briceño, Isabel; Calvo-A, Mario; Labarca, Jaime

    2014-04-01

    Bacteria antimicrobial resistance is an uncontrolled public health problem that progressively increases its magnitude and complexity. The Grupo Colaborativo de Resistencia, formed by a join of experts that represent 39 Chilean health institutions has been concerned with bacteria antimicrobial susceptibility in our country since 2008. In this document we present in vitro bacterial susceptibility accumulated during year 2012 belonging to 28 national health institutions that represent about 36% of hospital discharges in Chile. We consider of major importance to report periodically bacteria susceptibility so to keep the medical community updated to achieve target the empirical antimicrobial therapies and the control measures and prevention of the dissemination of multiresistant strains.

  5. Antimicrobial properties of hemoglobin.

    Science.gov (United States)

    Sheshadri, Preethi; Abraham, Jayanthi

    2012-12-01

    Hemoglobin consists of a heme containing component and a globin unit. It exists as a tetramer with 2 α subunits and 2 β subunits in adults and with 2 α subunits and 2 γ chains in infants. On proteolytic cleavage, hemoglobin breaks down to produce many biologically active compounds, among which are hemocidins, those which exhibit antimicrobial property. The generation of these peptides does not depend on the blood group, Rhesus factor, age and sex of the healthy donors. The microbicidal activity has been observed against a variety of gram positive and Gram-negative bacteria, and against filamentous fungi, yeast and even certain parasites. The discovery of hemocidins opens a new field for research into the details of the peptides acting as second line of defence in boosting the innate immune system of the organisms.

  6. Drug Utilization Study on Antimicrobial Use in Urinary Tract Infection

    Directory of Open Access Journals (Sweden)

    Sunil S Gidamudi

    2015-09-01

    Conclusion: The DDD/1000inhabitant/day of ceftriaxone was the highest (12.9. Third generation cephalosporins were used as first line drug in most cases. This group should be reserved for complicated UTIs. [Natl J Med Res 2015; 5(3.000: 216-221

  7. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Michigan. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Michigan Public Service Commission. The Commission is composed of three members appointed by the Governor with the advice and consent of the senate. Commission members are appointed for six-year terms. They must be free from pecuniary and employment interests incompatible with the duties of the Commission. The Commission is vested with complete power and jurisdiction to regulate all public utilities in the state except any municipally-owned utility. The Commission may not change any rates fixed in or regulated by a franchise granted by a municipality. Upon submission to the Commission by the municipality and the public utility operating in the municipality, the Commission may investigate and fix rates and establish rules and conditions of service. The jurisdiction of the Commission extends to all public utilities except municipally-owned utilities. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  8. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Iowa. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Iowa State Commerce Commission. The Commission is comprised of three members appointed by the governor with the approval of two-thirds of the senate. Commissioners are appointed for six-year terms. They must be free from employment or pecuniary interests in any public utility. Although the right to grant franchises is specifically reserved for municipalities, local governments exercise no regulatory authority over the provision of utility services by public utilities. Municipally-owned utilities, however, are specifically excepted from rate regulation by the Commission. The regulation of rates charged by municipally-owned utilities is the responsibility of local governments. The Commission is given no authority to review decisions of local governments with respect to rates. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  9. Antimicrobial seafood packaging: a review.

    Science.gov (United States)

    Singh, Suman; Ho Lee, Myung; Park, Lnsik; Shin, Yangjai; Lee, Youn Suk

    2016-06-01

    Microorganisms are the major cause of spoilage in most seafood products; however, only few microbes, called the specific spoilage organisms (SSOs), contribute to the offensive off-flavors associated with seafood spoilage. In food, microbial degradation manifests itself as spoilage, or changes in the sensory properties of a food product, rendering it unsuitable for human consumption. The use of antimicrobial substances can control the general microflora as well as specific microorganisms related to spoilage to provide products with higher safety and better quality. Many antimicrobial compounds have been evaluated in film structures for use in seafood, especially organic acids and their salts, enzymes, bacteriocins; some studies have considered inorganic compounds such as AgSiO2, zinc oxide, silver zeolite, and titanium oxide. The characteristics of some organic antimicrobial packaging systems for seafood and their antimicrobial efficiency in film structures are reviewed in this article. PMID:27478206

  10. Automation of antimicrobial activity screening.

    Science.gov (United States)

    Forry, Samuel P; Madonna, Megan C; López-Pérez, Daneli; Lin, Nancy J; Pasco, Madeleine D

    2016-03-01

    Manual and automated methods were compared for routine screening of compounds for antimicrobial activity. Automation generally accelerated assays and required less user intervention while producing comparable results. Automated protocols were validated for planktonic, biofilm, and agar cultures of the oral microbe Streptococcus mutans that is commonly associated with tooth decay. Toxicity assays for the known antimicrobial compound cetylpyridinium chloride (CPC) were validated against planktonic, biofilm forming, and 24 h biofilm culture conditions, and several commonly reported toxicity/antimicrobial activity measures were evaluated: the 50 % inhibitory concentration (IC50), the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC). Using automated methods, three halide salts of cetylpyridinium (CPC, CPB, CPI) were rapidly screened with no detectable effect of the counter ion on antimicrobial activity. PMID:26970766

  11. Should policy-makers allocate funding to vehicle electrification or end-use energy efficiency as a strategy for climate change mitigation and energy reductions? Rethinking electric utilities efficiency programs

    International Nuclear Information System (INIS)

    In order to reduce greenhouse gas emissions in the United States by an order of magnitude, a portfolio of mitigation strategies is needed. Currently, many utilities pursue energy efficiency programs. We study a case where utilities could choose whether to allocate their energy efficiency budget to either end-use efficiency or vehicle electrification as a means to reduce CO2 emissions. We build a decision space that displays the conditions under which utilities should pursue either strategy. To build such decision space, assumptions are needed on how consumers respond to electric vehicle incentives, and what would be the baseline vehicle selected by consumers if no incentives were in place. Since these two aspects are highly uncertain, we treat them parametrically: if consumers are replacing a conventional vehicle with a PHEV, utility incentive programs to induce PHEV adoption appear to be cost-effective for a wide range of efficiency program costs and grid emissions factors. - Highlights: • We compare subsidies for CO2 cuts with electric efficiency and plug-in hybrid vehicles. • Our model focuses PHEVs with a 20 km range and residential electric efficiency. • The subsidy choice depends on technical, economic, and regulatory factors. • These include grid emissions factor, size of subsidy, and efficiency program costs. • PHEV grants of $800-1000/vehicle make sense in most U.S. states without decoupling

  12. Human Antimicrobial Peptides and Proteins

    OpenAIRE

    Guangshun Wang

    2014-01-01

    As the key components of innate immunity, human host defense antimicrobial peptides and proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition, AMPs can possess other biological functions such as apoptosis, wound healing, and immune modulation. This article provides an overview on the identification, activity, 3D structure, and mechanism of action of human AMPs selected from the antimicrobial peptide database. Over 100 such peptides have been identified ...

  13. Antimicrobials for bacterial bioterrorism agents.

    Science.gov (United States)

    Sarkar-Tyson, Mitali; Atkins, Helen S

    2011-06-01

    The limitations of current antimicrobials for highly virulent pathogens considered as potential bioterrorism agents drives the requirement for new antimicrobials that are suitable for use in populations in the event of a deliberate release. Strategies targeting bacterial virulence offer the potential for new countermeasures to combat bacterial bioterrorism agents, including those active against a broad spectrum of pathogens. Although early in the development of antivirulence approaches, inhibitors of bacterial type III secretion systems and cell division mechanisms show promise for the future.

  14. Antimicrobial drugs for treating cholera

    OpenAIRE

    Leibovici-Weissman, Ya'ara; Neuberger, Ami; Bitterman, Roni; Sinclair, David; Salam, Mohammed Abdus; Paul, Mical

    2014-01-01

    Background Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which if severe can cause rapid dehydration and death. Effective management requires early diagnosis and rehydration using oral rehydration salts or intravenous fluids. In this review, we evaluate the additional benefits of treating cholera with antimicrobial drugs. Objectives To quantify the benefit of antimicrobial treatment for patients with cholera, and determine whether there are diffe...

  15. Burr Utility

    NARCIS (Netherlands)

    Ikefuji, M.; Laeven, R.J.A.; Magnus, J.R.; Muris, C.H.M.

    2010-01-01

    This note proposes the Burr utility function. Burr utility is a flexible two-parameter family that behaves approximately power-like (CRRA) remote from the origin, while exhibiting exponential-like (CARA) features near the origin. It thus avoids the extreme behavior of the power family near the origi

  16. Collaborative Approaches to Increase the Utility of Spatial Data for the Wildfire Management Community Through NASA's Applied Remote Sensing Training Program

    Science.gov (United States)

    McCullum, A. J. K.; Schmidt, C.; Blevins, B.; Weber, K.; Schnase, J. L.; Carroll, M.; Prados, A. I.

    2015-12-01

    The utility of spatial data products and tools to assess risk and effectively manage wildfires has increased, highlighting the need for communicating information about these new capabilities to decision makers, resource managers, and community leaders. NASA's Applied Remote Sensing Training (ARSET) program works directly with agencies and policy makers to develop in-person and online training courses that teach end users how to access, visualize, and apply NASA Earth Science data in their profession. The expansion of ARSET into wildfire applications began in 2015 with a webinar and subsequent in-person training hosted in collaboration with Idaho State University's (ISU) GIS Training and Research Center (TReC). These trainings featured presentations from the USDA Forest Service's Remote Sensing Training and Applications Center, the Land Processes DAAC, Northwest Nazarene University, NASA Goddard Space Flight Center, and ISU's GIS TReC. The webinar focused on providing land managers, non-governmental organizations, and international management agencies with an overview of 1) remote sensing platforms for wildfire applications, 2) products for pre- and post-fire planning and assessment, 3) the use of terrain data, 4) new techniques and technologies such as Unmanned Aircraft Systems and the Soil Moisture Active Passive Mission (SMAP), and 5) the RECOVER Decision Support System. This training highlighted online tools that engage the wildfire community through collaborative monitoring and assessment efforts. Webinar attendance included 278 participants from 178 organizations in 42 countries and 33 US states. The majority of respondents (93%) from a post-webinar survey indicated they displayed improvement in their understanding of specific remote-sensing data products appropriate for their work needs. With collaborative efforts between federal, state, and local agencies and academic institutions, increased use of NASA Earth Observations may lead to improved near real

  17. Toward utilization of data for program management and evaluation: quality assessment of five years of health management information system data in Rwanda

    Science.gov (United States)

    Nisingizwe, Marie Paul; Iyer, Hari S.; Gashayija, Modeste; Hirschhorn, Lisa R.; Amoroso, Cheryl; Wilson, Randy; Rubyutsa, Eric; Gaju, Eric; Basinga, Paulin; Muhire, Andrew; Binagwaho, Agnès; Hedt-Gauthier, Bethany

    2014-01-01

    Background Health data can be useful for effective service delivery, decision making, and evaluating existing programs in order to maintain high quality of healthcare. Studies have shown variability in data quality from national health management information systems (HMISs) in sub-Saharan Africa which threatens utility of these data as a tool to improve health systems. The purpose of this study is to assess the quality of Rwanda's HMIS data over a 5-year period. Methods The World Health Organization (WHO) data quality report card framework was used to assess the quality of HMIS data captured from 2008 to 2012 and is a census of all 495 publicly funded health facilities in Rwanda. Factors assessed included completeness and internal consistency of 10 indicators selected based on WHO recommendations and priority areas for the Rwanda national health sector. Completeness was measured as percentage of non-missing reports. Consistency was measured as the absence of extreme outliers, internal consistency between related indicators, and consistency of indicators over time. These assessments were done at the district and national level. Results Nationally, the average monthly district reporting completeness rate was 98% across 10 key indicators from 2008 to 2012. Completeness of indicator data increased over time: 2008, 88%; 2009, 91%; 2010, 89%; 2011, 90%; and 2012, 95% (p<0.0001). Comparing 2011 and 2012 health events to the mean of the three preceding years, service output increased from 3% (2011) to 9% (2012). Eighty-three percent of districts reported ratios between related indicators (ANC/DTP1, DTP1/DTP3) consistent with HMIS national ratios. Conclusion and policy implications Our findings suggest that HMIS data quality in Rwanda has been improving over time. We recommend maintaining these assessments to identify remaining gaps in data quality and that results are shared publicly to support increased use of HMIS data. PMID:25413722

  18. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Florida. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Florida Public Service Commission. The Commission is comprised of five members appointed by the governor with the approval of the senate. The governor must choose his appointees from a list of persons recommended by the nine-person Florida Public Service Commission Nominating Council. Commissioners serve either three- or four-year terms. They must be free from any employment or pecuniary interests in any utility subject to the jurisdiction of the Commission. Within the purview of its powers, the authority of the Commission supersedes that of local governments. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  19. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Vermont. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities is vested generally in the Vermont Public Service Board (PSC). The PSB is comprised of three members appointed by the governor with the advice and consent of the senate. PSB members serve six year terms. Members must be free from any employment or pecuniary interests in any company subject to the supervision of the PSB. Local governments retain little regulatory authority over public utilities. Local governments are responsible for regulating the use of streets and other public property, but any person aggrieved by a local decision may appeal to the PSB within thirty days. The PSB is to review the local action at a public hearing and its decision is final. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  20. Cholesterol suppresses antimicrobial effect of statins

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Haeri

    2015-12-01

    Full Text Available Objective(s:Isoprenoid biosynthesis is a key metabolic pathway to produce a wide variety of biomolecules such as cholesterol and carotenoids, which target cell membranes. On the other hand, it has been reported that statins known as inhibitors of isoprenoid biosynthesis and cholesterol lowering agents, may have a direct antimicrobial effect on the some bacteria. The exact action of statins in microbial metabolism is not clearly understood. It is possible that statins inhibit synthesis or utilization of some sterol precursor necessary for bacterial membrane integrity. Accordingly, this study was designed in order to examine if statins inhibit the production of a compound, which can be used in the membrane, and whether cholesterol would replace it and rescue bacteria from toxic effects of statins. Materials and Methods: To examine the possibility we assessed antibacterial effect of statins with different classes; lovastatin, simvastatin, and atorvastatin, alone and in combination with cholesterol on two Gram-positive (Staphylococcus aureus and Enterococcus faecalis and two Gram-negative (Pseudomonas aeruginosa and Escherichia coli bacteria using gel diffusion assay. Results: Our results showed that all of the statins except for lovastatin had significant antibacterial property in S. aureus, E. coli, and Enter. faecalis. Surprisingly, cholesterol nullified the antimicrobial action of effective statins in statin-sensitive bacteria. Conclusion: It is concluded that statins may deprive bacteria from a metabolite responsible for membrane stability, which is effectively substituted by cholesterol.

  1. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Maine. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The Maine Supreme Court holds that the regulation of the operations of public utilities is an exercise of the police powers of the state. The legislature has delegated such regulatory authority to the Maine Public Utilities Commission (PUC). The statutes provide no role for local government in the regulation of public utilities. The PUC consists of three full time members, appointed by the Governor subject to review by the Joint Standing Committee on Public Utilities and to confirmation by the Legislature. They each serve seven year terms. One member is designated by the Governor as chairman. The Commission appoints a secretary, assistant secretary, director of transportation, and, with the approval of the Attorney General, a general counsel. A member of the PUC cannot have any official or professional connection or relation with or hold any stock or securities in any public utility. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  2. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... Emergency Preparedness International Programs News & Events Training & Continuing ... Content Home Latest Recalls Report an Adverse Event MedWatch Safety Alerts News Releases ...

  3. Editorial of the Special Issue Antimicrobial Polymers

    Directory of Open Access Journals (Sweden)

    Iolanda Francolini

    2013-09-01

    Full Text Available The special issue “Antimicrobial Polymers” includes research and review papers concerning the recent advances on preparation of antimicrobial polymers and their relevance to industrial settings and biomedical field. Antimicrobial polymers have recently emerged as promising candidates to fight microbial contamination onto surfaces thanks to their interesting properties. In this special issue, the main strategies pursued for developing antimicrobial polymers, including polymer impregnation with antimicrobial agents or synthesis of polymers bearing antimicrobial moieties, were discussed. The future application of these polymers either in industrial or healthcare settings could result in an extremely positive impact not only at the economic level but also for the improvement of quality of life.

  4. Estimating Utility

    DEFF Research Database (Denmark)

    Arndt, Channing; Simler, Kenneth R.

    2010-01-01

    A fundamental premise of absolute poverty lines is that they represent the same level of utility through time and space. Disturbingly, a series of recent studies in middle- and low-income economies show that even carefully derived poverty lines rarely satisfy this premise. This article proposes...... an information-theoretic approach to estimating cost-of-basic-needs (CBN) poverty lines that are utility consistent. Applications to date illustrate that utility-consistent poverty measurements derived from the proposed approach and those derived from current CBN best practices often differ substantially...

  5. Antimicrobial resistance in bacteria from horses: Epidemiology of antimicrobial resistance.

    Science.gov (United States)

    Maddox, T W; Clegg, P D; Williams, N J; Pinchbeck, G L

    2015-11-01

    Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections. While the epidemiology of antimicrobial resistance in bacteria from man has been studied extensively, less work has been undertaken in companion animals, particularly horses. Methicillin-resistant Staphylococcus aureus has been identified as a cause of infections, with a low prevalence of nasal carriage by horses in the community but higher for hospitalised horses. Molecular characterisation has shown methicillin-resistant Staphylococcus aureus strains either to be predominantly of types associated with horses or of sequence type ST398. Antimicrobial-resistant Escherichia coli (including multidrug-resistant and extended spectrum β-lactamase-producing isolates) have caused infections and been documented in faecal carriage by horses, with many significant resistance mechanisms identified. More sporadic reports and molecular characterisation exist for resistance in other bacteria such as enterococci, Salmonella, Acinetobacter and Pseudomonas species. Limited work has been undertaken evaluating risk factors and much of the epidemiology of antimicrobial resistance in bacteria from horses remains to be determined.

  6. Antimicrobial resistance in bacteria from horses: Epidemiology of antimicrobial resistance.

    Science.gov (United States)

    Maddox, T W; Clegg, P D; Williams, N J; Pinchbeck, G L

    2015-11-01

    Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections. While the epidemiology of antimicrobial resistance in bacteria from man has been studied extensively, less work has been undertaken in companion animals, particularly horses. Methicillin-resistant Staphylococcus aureus has been identified as a cause of infections, with a low prevalence of nasal carriage by horses in the community but higher for hospitalised horses. Molecular characterisation has shown methicillin-resistant Staphylococcus aureus strains either to be predominantly of types associated with horses or of sequence type ST398. Antimicrobial-resistant Escherichia coli (including multidrug-resistant and extended spectrum β-lactamase-producing isolates) have caused infections and been documented in faecal carriage by horses, with many significant resistance mechanisms identified. More sporadic reports and molecular characterisation exist for resistance in other bacteria such as enterococci, Salmonella, Acinetobacter and Pseudomonas species. Limited work has been undertaken evaluating risk factors and much of the epidemiology of antimicrobial resistance in bacteria from horses remains to be determined. PMID:26084443

  7. Antimicrobial Peptides from Plants

    Science.gov (United States)

    Tam, James P.; Wang, Shujing; Wong, Ka H.; Tan, Wei Liang

    2015-01-01

    Plant antimicrobial peptides (AMPs) have evolved differently from AMPs from other life forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the disulfides cross-braced plant AMPs as cystine-rich peptides to confer them with extraordinary high chemical, thermal and proteolytic stability. The cystine-rich or commonly known as cysteine-rich peptides (CRPs) of plant AMPs are classified into families based on their sequence similarity, cysteine motifs that determine their distinctive disulfide bond patterns and tertiary structure fold. Cystine-rich plant AMP families include thionins, defensins, hevein-like peptides, knottin-type peptides (linear and cyclic), lipid transfer proteins, α-hairpinin and snakins family. In addition, there are AMPs which are rich in other amino acids. The ability of plant AMPs to organize into specific families with conserved structural folds that enable sequence variation of non-Cys residues encased in the same scaffold within a particular family to play multiple functions. Furthermore, the ability of plant AMPs to tolerate hypervariable sequences using a conserved scaffold provides diversity to recognize different targets by varying the sequence of the non-cysteine residues. These properties bode well for developing plant AMPs as potential therapeutics and for protection of crops through transgenic methods. This review provides an overview of the major families of plant AMPs, including their structures, functions, and putative mechanisms. PMID:26580629

  8. Antimicrobial Peptides from Plants

    Directory of Open Access Journals (Sweden)

    James P. Tam

    2015-11-01

    Full Text Available Plant antimicrobial peptides (AMPs have evolved differently from AMPs from other life forms. They are generally rich in cysteine residues which form multiple disulfides. In turn, the disulfides cross-braced plant AMPs as cystine-rich peptides to confer them with extraordinary high chemical, thermal and proteolytic stability. The cystine-rich or commonly known as cysteine-rich peptides (CRPs of plant AMPs are classified into families based on their sequence similarity, cysteine motifs that determine their distinctive disulfide bond patterns and tertiary structure fold. Cystine-rich plant AMP families include thionins, defensins, hevein-like peptides, knottin-type peptides (linear and cyclic, lipid transfer proteins, α-hairpinin and snakins family. In addition, there are AMPs which are rich in other amino acids. The ability of plant AMPs to organize into specific families with conserved structural folds that enable sequence variation of non-Cys residues encased in the same scaffold within a particular family to play multiple functions. Furthermore, the ability of plant AMPs to tolerate hypervariable sequences using a conserved scaffold provides diversity to recognize different targets by varying the sequence of the non-cysteine residues. These properties bode well for developing plant AMPs as potential therapeutics and for protection of crops through transgenic methods. This review provides an overview of the major families of plant AMPs, including their structures, functions, and putative mechanisms.

  9. Antimicrobial peptides in annelids

    Directory of Open Access Journals (Sweden)

    A Tasiemski

    2008-06-01

    Full Text Available Gene encoded antimicrobial peptides (AMPs are widely distributed among living organisms including plants, invertebrates and vertebrates. They constitute important effectors of the innate immune response by exerting multiple roles as mediators of inflammation with impact on epithelial and inflammatory cells influencing diverse processes such as cytokine release, cell proliferation, angiogenesis, wound healing, chemotaxis and immune induction. In invertebrates, most of the data describe the characterization and/or the function of AMPs in the numerically and economically most representative group which are arthropods. Annelids are among the first coelomates and are therefore of special phylogenetic interest. Compared to other invertebrate groups, data on annelid’s immunity reveal heavier emphasis on the cellular than on the humoral response suggesting that immune defense of annelids seems to be principally developed as cellular immunity.This paper gives an overview of the variety of AMPs identified in the three classes of annelids, i.e. polychaetes, oligochaetes and achaetes. Their functions, when they have been studied, in the humoral or cellular response of annelids are also mentioned.

  10. Antimicrobial peptides in crustaceans

    Directory of Open Access Journals (Sweden)

    RD Rosa

    2010-11-01

    Full Text Available Crustaceans are a large and diverse invertebrate animal group that mounts a complex and efficient innate immune response against a variety of microorganisms. The crustacean immune system is primarily related to cellular responses and the production and release of important immune effectors into the hemolymph. Antimicrobial proteins and/or peptides (AMPs are key components of innate immunity and are widespread in nature, from bacteria to vertebrate animals. In crustaceans, 15 distinct AMP families are currently recognized, although the great majority (14 families comes from members of the order Decapoda. Crustacean AMPs are generally cationic, gene-encoded molecules that are mainly produced by circulating immune-competent cells (hemocytes or are derived from unrelated proteins primarily involved in other biological functions. In this review, we tentatively classified the crustacean AMPs into four main groups based on their amino acid composition, structural features and multi-functionality. We also attempted to summarize the current knowledge on their implication both in an efficient response to microbial infections and in crustacean survival.

  11. Enhancing US-Japan cooperation to combat antimicrobial resistance.

    Science.gov (United States)

    Gerbin, C Sachi

    2014-01-01

    The Global Health Security Agenda (GHSA) is aimed at preventing, detecting, and responding to infectious disease threats. To move toward these goals, the United States has committed to partner with at least 30 countries around the world. One of the objectives of the GHSA includes "[p]reventing the emergence and spread of antimicrobial drug resistant organisms." Antimicrobial resistance (AMR) has become a growing global health security problem, with inappropriate use of antimicrobial medications in humans and animals and a lack of new antimicrobial medications contributing to this problem. While AMR is a growing global concern, working on it regionally can make this multifaceted problem more manageable. The United States and Japan, both world leaders in the life sciences, are close allies that have established cooperative programs in medical research and global health that can be used to work on combating AMR and advance the GHSA. Although the United States and Japan have cooperated on health issues in the past, their cooperation on the growing problem of AMR has been limited. Their existing networks, cooperative programs, and close relationships can and should be used to work on combating this expanding problem.

  12. Subsurface Utility Engineering for Drinking Water and Wastewater Utilities

    Directory of Open Access Journals (Sweden)

    Berk Uslu,

    2015-11-01

    Full Text Available Buried utility locating practices are an integral part of condition assessment, renewal engineering, and damage prevention programs for drinking water and wastewater utilities. An extensive literature review was conducted to determine the underground utility practices, locating technologies, data management practice, as well as education and outreach programs. This literature review synthesized the practices form other industries. The practices from water and wastewater utilities were determined by the help of participation utilities to the WATERiD Database. Case studies in locating technology applications and locating practice application was written to capture these practices. These case studies were also supplemented by phone interviews with various utilities. Comparison between the literature and utility practice indicated various gaps in the utility practice. Recommendations are offered to fill these gaps for an effective use of underground utility practices by water and wastewater utilities. These recommendation include adaptation and implementation of specific best practices of transportation industry by the water and wastewater utilities. Specifically, adaptations of; standards, decision support tools for data quality levels and locating technologies, data standardization and integration, as well as participation on education and outreach programs are discussed.

  13. Antimicrobial resistance in Scandinavia after ban of antimicrobial growth promoters.

    Science.gov (United States)

    Bengtsson, Björn; Wierup, Martin

    2006-01-01

    The banned use of antimicrobial growth promoters resulted in a considerably decreased use of antimicrobials in food animal production in Sweden (65%), Denmark (47%), Norway (40%) and Finland (27%). The current prevalence of antimicrobial resistance in animal bacterial populations is also considerably lower than in some other countries in the EU. In the swine production, no or limited effect was found in the finisher production (>25 to 30 kg). Temporary negative effects occurred during the post weaning period (7-30 kg). In Denmark, the cost of production from birth to slaughter per pig produced increased by approximately 1.0 euro with a high variability between pig producers. In the broiler production the termination had no significant negative effect on animal health and welfare or on production economy.

  14. A Classroom Mathematics Utility.

    Science.gov (United States)

    Williams, Michael

    1984-01-01

    Reviews CATUSPLOT, a mathematics utility aimed at high school algebra through college-level calculus. Basic program capabilities include plotting, tabulating, integrating, and locating of intersections of functions composed of combinations of polynomial, trigonometric, and exponential functions. Rated excellent on all areas examined…

  15. Epithelial Antimicrobial Peptides: Guardian of the Oral Cavity

    Directory of Open Access Journals (Sweden)

    Mayank Hans

    2014-01-01

    Full Text Available Gingival epithelium provides first line of defence from the microorganisms present in dental plaque. It not only provides a mechanical barrier but also has an active immune function too. Gingival epithelial cells participate in innate immunity by producing a range of antimicrobial peptides to protect the host against oral pathogens. These epithelial antimicrobial peptides (EAPs include the β-defensin family, cathelicidin (LL-37, calprotectin, and adrenomedullin. While some are constitutively expressed in gingival epithelial cells, others are induced upon exposure to microbial insults. It is likely that these EAPs have a role in determining the initiation and progression of oral diseases. EAPs are broad spectrum antimicrobials with a different but overlapping range of activity. Apart from antimicrobial activity, they participate in several other crucial roles in host tissues. Some of these, for instance, β-defensins, are chemotactic to immune cells. Others, such as calprotectin are important for wound healing and cell proliferation. Adrenomedullin, a multifunctional peptide, has its biological action in a wide range of tissues. Not only is it a potent vasodilator but also it has several endocrine effects. Knowing in detail the various bioactions of these EAPs may provide us with useful information regarding their utility as therapeutic agents.

  16. Antimicrobial activities of squalamine mimics.

    Science.gov (United States)

    Kikuchi, K; Bernard, E M; Sadownik, A; Regen, S L; Armstrong, D

    1997-07-01

    We investigated the antimicrobial properties of compounds with structural features that were designed to mimic those of squalamine, an antibiotic isolated from the stomach of the dogfish shark. The mimics, like squalamine, are sterol-polyamine conjugates. Unlike squalamine, the mimics were simple to prepare, at high yield, from readily available starting materials. Several squalamine mimics showed activity against gram-negative rods, gram-positive cocci including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and fungi. Some had little or no hemolytic activity. The hydrophobicity of the sterol backbone and the length and the cationic charge of the side chains appeared to be critical determinants of activity. One of the squalamine mimics, SM-7, was bactericidal against Escherichia coli, Pseudomonas aeruginosa, and S. aureus; its activity was decreased by divalent or monovalent cations and by bovine serum albumin. Subinhibitory concentrations of SM-7 markedly enhanced the antimicrobial activity of rifampin against gram-negative rods. These results suggest that the compounds may disrupt an outer membrane of gram-negative rods. Squalamine mimics are a new class of broad-spectrum antimicrobial agents. The antagonism of their activity by serum and albumin and their hemolytic properties may limit their use as systemic agents. The squalamine mimics, because of their potencies, broad spectra of antimicrobial activity, and potential for systemic toxicity, appear to be good candidates for development as topical antimicrobial agents. PMID:9210661

  17. Animation of Antimicrobial Resistance

    Medline Plus

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    Full Text Available ... resistance more real and understandable to veterinarians, livestock producers, lawmakers, consumer representatives and other key audiences. We ... Regulatory Information Safety Emergency Preparedness International Programs News & ... Training & Continuing Education Inspections & Compliance Federal, State & Local ...

  19. Animation of Antimicrobial Resistance

    Medline Plus

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  20. Animation of Antimicrobial Resistance

    Medline Plus

    Full Text Available ... Emergency Preparedness International Programs News & Events Training & Continuing Education Inspections & Compliance Federal, State & Local Officials Consumers Health Professionals Science & Research Industry Scroll back to top Popular Content Home ...

  1. The utilization of accelerators in subcritical systems for energy generation and nuclear waste transmutation - the world status and a proposal of a national R and D program

    Energy Technology Data Exchange (ETDEWEB)

    Maiorino, Jose Rubens; Santos, Adimir dos; Pereira, Sergio Anefalos [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    2003-06-01

    A summary of the world status on R and D related to the utilization of Accelerator Driven System for energy generation and mainly for transmutation of long lived nuclear waste is presented. A proposal to start a Technical Working Group in Brazil to prepare a Road Map having as a final goal an experimental facility to utilize an accelerator in basic and applied research; products and services and R and D in energy generation and transmutation are presented. (author)

  2. Antimicrobial resistance of thermophilic Campylobacter

    DEFF Research Database (Denmark)

    Aarestrup, Frank Møller; Engberg, J.

    2001-01-01

    Campylobacter has become the leading cause of zoonotic enteric infections in developed and developing countries world-wide. Antimicrobial resistance has emerged among Campylobacter mainly as a consequence of the use of antimicrobial agents in food animal production. Resistance to drugs of choice...... for the treatment of infections, macrolides and fluoroquinolones has emerged as a clinical problem and interventions to reduce this are recommended. Resistance to fluoroquinolones and macrolides is mediated by chromosomal mutations. Resistance to other relevant antimicrobial agents, mediated by...... acquired resistance genes, has not become widespread so far. However, resistance genes originating from both Gram-positive and Gram-negative bacterial species have been found, showing the potential for acquired resistance to emerge in Campylobacter....

  3. Isolation and Characterization of Antimicrobial-Resistant Nontyphoidal Salmonella enterica Serovars from Imported Food Products.

    Science.gov (United States)

    Bae, Dongryeoul; Kweon, Ohgew; Khan, Ashraf A

    2016-08-01

    The objective of this study was to determine antimicrobial resistance and elucidate the resistance mechanism in nontyphoidal Salmonella enterica serovars isolated from food products imported into the United States from 2011 to 2013. Food products contaminated with antimicrobial-resistant nontyphoidal S. enterica were mainly imported from Taiwan, Indonesia, Vietnam, and China. PCR, DNA sequencing, and plasmid analyses were used to characterize antimicrobial resistance determinants. Twentythree of 110 S. enterica isolates were resistant to various antimicrobial classes, including β-lactam, aminoglycoside, phenicol, glycopeptide, sulfonamide, trimethoprim, and/or fluoroquinolone antimicrobial agents. Twelve of the isolates were multidrug resistant strains. Antimicrobial resistance determinants blaTEM-1, blaCTX-M-9, blaOXA-1, tetA, tetB, tetD, dfrA1, dfrV, dhfrI, dhfrXII, drf17, aadA1, aadA2, aadA5, orfC, qnrS, and mutations of gyrA and parC were detected in one or more antimicrobial-resistant nontyphoidal S. enterica strains. Plasmid profiles revealed that 12 of the 23 antimicrobial-resistant strains harbored plasmids with incompatibility groups IncFIB, IncHI1, IncI1, IncN, IncW, and IncX. Epidemiologic and antimicrobial resistance monitoring data combined with molecular characterization of antimicrobial resistance determinants in Salmonella strains isolated from imported food products may provide information that can be used to establish or implement food safety programs to improve public health.

  4. Isolation and Characterization of Antimicrobial-Resistant Nontyphoidal Salmonella enterica Serovars from Imported Food Products.

    Science.gov (United States)

    Bae, Dongryeoul; Kweon, Ohgew; Khan, Ashraf A

    2016-08-01

    The objective of this study was to determine antimicrobial resistance and elucidate the resistance mechanism in nontyphoidal Salmonella enterica serovars isolated from food products imported into the United States from 2011 to 2013. Food products contaminated with antimicrobial-resistant nontyphoidal S. enterica were mainly imported from Taiwan, Indonesia, Vietnam, and China. PCR, DNA sequencing, and plasmid analyses were used to characterize antimicrobial resistance determinants. Twentythree of 110 S. enterica isolates were resistant to various antimicrobial classes, including β-lactam, aminoglycoside, phenicol, glycopeptide, sulfonamide, trimethoprim, and/or fluoroquinolone antimicrobial agents. Twelve of the isolates were multidrug resistant strains. Antimicrobial resistance determinants blaTEM-1, blaCTX-M-9, blaOXA-1, tetA, tetB, tetD, dfrA1, dfrV, dhfrI, dhfrXII, drf17, aadA1, aadA2, aadA5, orfC, qnrS, and mutations of gyrA and parC were detected in one or more antimicrobial-resistant nontyphoidal S. enterica strains. Plasmid profiles revealed that 12 of the 23 antimicrobial-resistant strains harbored plasmids with incompatibility groups IncFIB, IncHI1, IncI1, IncN, IncW, and IncX. Epidemiologic and antimicrobial resistance monitoring data combined with molecular characterization of antimicrobial resistance determinants in Salmonella strains isolated from imported food products may provide information that can be used to establish or implement food safety programs to improve public health. PMID:27497122

  5. Uses of antimicrobial genes from microbial genome

    Science.gov (United States)

    Sorek, Rotem; Rubin, Edward M.

    2013-08-20

    We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.

  6. A study of language learning strategies that successful pre-service teachers utilize in English pedagogy programs at two universities in Concepción, Chile: a case study

    Directory of Open Access Journals (Sweden)

    Lea Hitt

    2015-01-01

    Full Text Available This study attempts to uncover the Language Learning Strategies (LLSs utilized by proficient language learners in English pedagogy programs at two universities. It was found that students employ indirect strategies frequently, which are of a metacognitive nature. Through a case study methodology, these students were asked to do a semi-structured interview and a think-aloud protocol. It was found that cognitive and metacognitive strategies were the most prevalent.

  7. Multiattribute Utility Theory without Expected Utility Foundations

    NARCIS (Netherlands)

    A.M. Stiggelbout; P.P. Wakker

    1995-01-01

    Methods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities, and simplifying decompositions of multiattribute utilities. Th

  8. Multiattribute utility theory without expected utility foundations

    NARCIS (Netherlands)

    P.P. Wakker; J. Miyamoto

    1996-01-01

    Methods for determining the form of utilities are needed for the implementation of utility theory in specific decisions. An important step forward was achieved when utility theorists characterized useful parametric families of utilities, and simplifying decompositions of multiattribute utilities. Th

  9. Evaluation of the Antimicrobial Triclocarban in a Short-term Reproduction Assay with the Fathead Minnow Pimephales promelas

    Science.gov (United States)

    Triclocarban, commercially known as TCC, is a trichlorinated pesticide used extensively as an antimicrobial additive in personal care products. TCC is characterized as a high production volume chemical and recent monitoring programs have shown it is prevalent in aquatic environme...

  10. Utility service entrance in boreholes

    International Nuclear Information System (INIS)

    This study evaluates alternatives for utility service entrances to the repository. We determined the requirements for a repository utility supply. These requirements were defined as safety, maintainability, flexibility, reliability, cost efficiency, voltage regulation, and simplicity of operation. The study showed that repository shafts can best satisfy all requirements for location of the utility supply without the use of borehole penetrations into the repository. It is recommended that the shafts be utilized for utility distribution to the repository, and that the current NWTS program position to minimize the number of boreholes penetrating the repository horizon be maintained. 42 refs., 2 figs., 3 tabs

  11. A Church-Based, Spanish-Language Community Education Breast Health Program Increases Awareness and Utilization of Breast Diagnostic Services among Hispanics

    Science.gov (United States)

    Colon-Otero, Gerardo; Albertie, Monica; Rodriguez, Judith; Nicholson, Garik; Kolomeyer, Irina; Moreno-Aspitia, Alvaro; Lesperance, Mary; Perez, Edith A.

    2014-01-01

    The Mayo Clinic Disparities Program and the University of North Florida Brooks College of Health partnered with representatives of the Hispanic community of Northeast Florida to develop an educational program aimed at raising awareness of the importance of diet in breast cancer prevention and availability of free breast cancer screening. An…

  12. Exploring Changes and Perceptions in Environmental Attitudes as a Result of Early Learning Experiences in the Outdoor World Utilizing Spark, an Innovative Family Learning Program

    Science.gov (United States)

    Satterlee, Donna Jean

    2010-01-01

    This dissertation explores the long-term influence of the SPARK Program (Shore People Advancing Readiness for Knowledge) on the environmental attitudes of some of its alumni. SPARK was designed for parents and their preschool children who live in a rural area on the Eastern Shore of Virginia. The main goal of this program is to provide…

  13. Effectiveness of the Surviving the Teens® Suicide Prevention and Depression Awareness Program: An Impact Evaluation Utilizing a Comparison Group

    Science.gov (United States)

    Strunk, Catherine M.; King, Keith A.; Vidourek, Rebecca A.; Sorter, Michael T.

    2014-01-01

    Youth suicide is a serious public health issue in the United States. It is currently the third leading cause of death for youth aged 10 to 19. School-based prevention programs may be an effective method of educating youth and enhancing their help-seeking. Most school-based suicide prevention programs have not been rigorously evaluated for their…

  14. The Utility of the Memorable Messages Framework as an Intermediary Evaluation Tool for Fruit and Vegetable Consumption in a Nutrition Education Program

    Science.gov (United States)

    Davis, LaShara A.; Morgan, Susan E.; Mobley, Amy R.

    2016-01-01

    Additional strategies to evaluate the impact of community nutrition education programs on low-income individuals are needed. The objective of this qualitative study was to examine the use of the Memorable Messages Framework as an intermediary nutrition education program evaluation tool to determine what fruit and vegetable messages were reported…

  15. Antimicrobial Polymers with Metal Nanoparticles

    Directory of Open Access Journals (Sweden)

    Humberto Palza

    2015-01-01

    Full Text Available Metals, such as copper and silver, can be extremely toxic to bacteria at exceptionally low concentrations. Because of this biocidal activity, metals have been widely used as antimicrobial agents in a multitude of applications related with agriculture, healthcare, and the industry in general. Unlike other antimicrobial agents, metals are stable under conditions currently found in the industry allowing their use as additives. Today these metal based additives are found as: particles, ions absorbed/exchanged in different carriers, salts, hybrid structures, etc. One recent route to further extend the antimicrobial applications of these metals is by their incorporation as nanoparticles into polymer matrices. These polymer/metal nanocomposites can be prepared by several routes such as in situ synthesis of the nanoparticle within a hydrogel or direct addition of the metal nanofiller into a thermoplastic matrix. The objective of the present review is to show examples of polymer/metal composites designed to have antimicrobial activities, with a special focus on copper and silver metal nanoparticles and their mechanisms.

  16. Antimicrobial activity of Securidaca longipedunculata.

    Science.gov (United States)

    Ajali, U; Chukwurah, B K C

    2004-11-01

    The folk herbal uses of Securidaca longipedunculata in the treatment of diarrhea, boils, gonorrhea, and cough prompted phytochemical analyses and antimicrobial activity screening of extracts of the root. Some flavonoids isolated showed activity against many micro-organisms. These flavonoids were isolated using chromatographic methods. PMID:15636189

  17. Helical Antimicrobial Sulfono- {gamma} -AApeptides

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yaqiong; Wu, Haifan; Teng, Peng; Bai, Ge; Lin, Xiaoyang; Zuo, Xiaobing; Cao, Chuanhai; Cai, Jianfeng

    2015-06-11

    Host-defense peptides (HDPs) such as magainin 2 have emerged as potential therapeutic agents combating antibiotic resistance. Inspired by their structures and mechanism of action, herein we report the fi rst example of antimicrobial helical sulfono- γ - AApeptide foldamers. The lead molecule displays broad-spectrum and potent antimicrobial activity against multi-drug-resistant Gram- positive and Gram-negative bacterial pathogens. Time-kill studies and fl uorescence microscopy suggest that sulfono- γ -AApeptides eradicate bacteria by taking a mode of action analogous to that of HDPs. Clear structure - function relationships exist in the studied sequences. Longer sequences, presumably adopting more-de fi ned helical structures, are more potent than shorter ones. Interestingly, the sequence with less helical propensity in solution could be more selective than the stronger helix-forming sequences. Moreover, this class of antimicrobial agents are resistant to proteolytic degradation. These results may lead to the development of a new class of antimicrobial foldamers combating emerging antibiotic-resistant pathogens.

  18. Antimicrobial Activity of Resveratrol Analogues

    Directory of Open Access Journals (Sweden)

    Malik Chalal

    2014-06-01

    Full Text Available Stilbenes, especially resveratrol and its derivatives, have become famous for their positive effects on a wide range of medical disorders, as indicated by a huge number of published studies. A less investigated area of research is their antimicrobial properties. A series of 13 trans-resveratrol analogues was synthesized via Wittig or Heck reactions, and their antimicrobial activity assessed on two different grapevine pathogens responsible for severe diseases in the vineyard. The entire series, together with resveratrol, was first evaluated on the zoospore mobility and sporulation level of Plasmopara viticola (the oomycete responsible for downy mildew. Stilbenes displayed a spectrum of activity ranging from low to high. Six of them, including the most active ones, were subsequently tested on the development of Botrytis cinerea (fungus responsible for grey mold. The results obtained allowed us to identify the most active stilbenes against both grapevine pathogens, to compare the antimicrobial activity of the evaluated series of stilbenes, and to discuss the relationship between their chemical structure (number and position of methoxy and hydroxy groups and antimicrobial activity.

  19. Evaluation of Final Radiological Conditions at Areas of the Niagara Falls Storage Site Remediated under the Formerly Utilized Sites Remedial Action Program - 12184

    Energy Technology Data Exchange (ETDEWEB)

    Clayton, Christopher [U.S Department of Energy Office of Legacy Management, Washington, DC (United States); Kothari, Vijendra [U.S Department of Energy Office of Legacy Management, Morgantown, West Virginia (United States); Starr, Ken [U.S Department of Energy Office of Legacy Management, Westminster, Colorado (United States); Widdop, Michael; Gillespie, Joey [SM Stoller Corporation, Grand Junction, Colorado (United States)

    2012-07-01

    The U.S. Department of Energy (DOE) methods and protocols allow evaluation of remediation and final site conditions to determine if remediated sites remain protective. Two case studies are presented that involve the Niagara Falls Storage Site (NFSS) and associated vicinity properties (VPs), which are being remediated under the Formerly Utilized Sites Remedial Action Program (FUSRAP). These properties are a part of the former Lake Ontario Ordnance Works (LOOW). In response to stakeholders concerns about whether certain remediated NFSS VPs were putting them at risk, DOE met with stakeholders and agreed to evaluate protectiveness. Documentation in the DOE records collection adequately described assessed and final radiological conditions at the completed VPs. All FUSRAP wastes at the completed sites were cleaned up to meet DOE guidelines for unrestricted use. DOE compiled the results of the investigation in a report that was released for public comment. In conducting the review of site conditions, DOE found that stakeholders were also concerned about waste from the Separations Process Research Unit (SPRU) at the Knolls Atomic Power Laboratory (KAPL) that was handled at LOOW. DOE agreed to determine if SPRU waste remained at that needed to be remediated. DOE reviewed records of waste characterization, historical handling locations and methods, and assessment and remediation data. DOE concluded that the SPRU waste was remediated on the LOOW to levels that pose no unacceptable risk and allow unrestricted use and unlimited exposure. This work confirms the following points as tenets of an effective long-term surveillance and maintenance (LTS and M) program: - Stakeholder interaction must be open and transparent, and DOE must respond promptly to stakeholder concerns. - DOE, as the long-term custodian, must collect and preserve site records in order to demonstrate that remediated sites pose no unacceptable risk. - DOE must continue to maintain constructive relationships with

  20. Combating Antimicrobial Resistance in Foodborne Microorganisms.

    Science.gov (United States)

    Lai, Edward P C; Iqbal, Zafar; Avis, Tyler J

    2016-02-01

    This review addresses an important public health hazard affecting food safety. Antimicrobial agents are used in foods to reduce or eliminate microorganisms that cause disease. Many traditional organic compounds, novel synthetic organic agents, natural products, peptides, and proteins have been extensively studied for their effectiveness as antimicrobial agents against foodborne Campylobacter spp., Escherichia coli, Listeria spp. and Salmonella. However, antimicrobial resistance can develop in microorganisms, enhancing their ability to withstand the inhibiting or killing action of antimicrobial agents. Knowledge gaps still exist with regard to the actual chemical and microbiological mechanisms that must be identified to facilitate the search for new antimicrobial agents. Technical implementation of antimicrobial active packing films and coatings against target microorganisms must also be improved for extended product shelf life. Recent advances in antimicrobial susceptibility testing can provide researchers with new momentum to pursue their quest for a resistance panacea.

  1. Does the Universal Health Insurance Program Affect Urban-Rural Differences in Health Service Utilization among the Elderly? Evidence from a Longitudinal Study in Taiwan

    Science.gov (United States)

    Liao, Pei-An; Chang, Hung-Hao; Yang, Fang-An

    2012-01-01

    Purpose: To assess the impact of the introduction of Taiwan's National Health Insurance (NHI) on urban-rural inequality in health service utilization among the elderly. Methods: A longitudinal data set of 1,504 individuals aged 65 and older was constructed from the Survey of Health and Living Status of the Elderly. A difference-in-differences…

  2. Cost-utility and cost-effectiveness analyses of a long-term, high-intensity exercise program compared with conventional physical therapy in patients with rheumatoid arthritis.

    NARCIS (Netherlands)

    Hout, W.B. van den; Jong, Z. de; Munneke, M.; Hazes, J.M.W.; Breedveld, F.C.; Vliet Vlieland, T.P.M.

    2005-01-01

    OBJECTIVE: To estimate the cost utility and cost effectiveness of long-term, high-intensity exercise classes compared with usual care in rheumatoid arthritis (RA) patients. METHODS: RA patients (n = 300) were randomly assigned to either exercise classes or UC; followup lasted for 2 years. Outcome me

  3. Bacterial distribution and antimicrobial resistance in urine specimens in China antibiotic resistance surveillance program CHINET 2010%2010年中国CHINET尿液标本中细菌的分布和耐药性监测

    Institute of Scientific and Technical Information of China (English)

    朱德妹; 徐元宏; 沈继录; 孙自镛; 陈中举; 徐英春; 张小江; 单斌; 杜艳; 卓超; 苏丹虹; 汪复; 胡云建; 艾效曼; 张朝霞; 季萍; 贾蓓; 黄文祥; 张泓; 孔菁; 魏莲花; 吴玲; 胡付品; 倪语星; 孙景勇; 王传清; 王爱敏; 俞云松; 杨青

    2012-01-01

    across 14 teaching hospitals in several regions of China. Methods Twelve general hospitals and two children's hospitals were involved in this program. Bacterial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method. Results were analyzed according to the breakpoints of CLSI 2010. Results A total of 9 301 clinical isolates were collected from urine specimens from January to December 2010, accounting for 19.4% of all the clinical isolates during the same period (9 301/47 850). Of the 9 301 isolates, 74. 2% (6 898/9 301) were gram negative organisms, 25. 8% (2 403/9 301) were gram-positive. E. coli was the most prevalent species, accounting for 49. 0% , followed by Enterococcus spp. (22. 1%). About 68% of the strains were isolated from hospitalized patients, 32% of the strains from outpatients and emergency patients. About 64% of the strains were isolated from female patients, 32% from male patients. The prevalence of ESBLs-producing strains in E. coli, Klebsiella spp, (K. pneumoniae and K. oxytoca ) and P. mirabilis w 58. 4 %, 59. 8% and 14. 4%, similar to the prevalence in other specimens during the same period. A small number of vancomycin-resistant strains were identified in E. faecalis and E, faecium . The prevalence of VRE was 0. 5% in- 5) in E. faecalis and 2. 4% in- 24) in E. faecium. Fewer than 10% of the E. faecalis isolates were resistant to nitro-furantoin, fosfomycin or ampicillin. The E. faecium isolates were mostly (40% to 94%) resistant to the antibiotics tested except glycopeptides, linezolid and fosfomycin. The percentage of the carbapenem-resistant E. coli strains was slightly lower than the corresponding data in other specimens during the same period. P. aeruginosa and Acinetobacter spp. strains showed lower resistance to carbapenems in comparison to the data in other specimens. A few pan-resistant strains were identified in some En-terobacteriaceae and non-fermentative species. Conclusions E. coli is the leading

  4. A Meta-Analysis of Health Status, Health Behaviors, and Health Care Utilization Outcomes of the Chronic Disease Self-Management Program

    OpenAIRE

    Brady, Teresa J; Murphy, Louise; O’Colmain, Benita J.; Beauchesne, Danielle; Daniels, Brandy; Greenberg, Michael; House, Marnie; Chervin, Doryn

    2013-01-01

    Introduction The Chronic Disease Self-Management Program (CDSMP) is a community-based self-management education program designed to help participants gain confidence (self-efficacy) and skills to better manage their chronic conditions; it has been implemented worldwide. The objective of this meta-analysis was to quantitatively synthesize the results of CDSMP studies conducted in English-speaking countries to determine the program’s effects on health behaviors, physical and psychological healt...

  5. Tribal Veterans Representative (TVR) training program: the effect of community outreach workers on American Indian and Alaska Native Veterans access to and utilization of the Veterans Health Administration.

    Science.gov (United States)

    Kaufmann, L Jeanne; Buck Richardson, W J; Floyd, James; Shore, Jay

    2014-10-01

    American Indians and Alaska Natives serve at the highest rate of any US race or ethnic group, yet are the most underserved population of Veterans and do not take advantage of the Department of Veterans Affairs (VA) benefits and services. Barriers to seeking care include stigma, especially for mental health issues; distance to care; and lack of awareness of benefits and services they are entitled to receive. In response to this underutilization of the VA, an innovative program--the Tribal Veterans Representative (TVR) program--was developed within the VA to work with American Indians and Alaska Natives in rural and remote areas. The TVR goes through extensive training every year; is a volunteer, a Veteran and tribal community member who seeks out unenrolled Native Veterans, provides them with information on VA health care services and benefits, and assists them with enrollment paperwork. Being from the community they serve, these outreach workers are able to develop relationships and build rapport and trust with fellow Veterans. In place for over a decade in Montana, this program has enrolled a countless number of Veterans, benefiting not only the individual, but their family and the community as well. Also resulting from this program, are the implementation of Telemental Health Clinics treating Veterans with PTSD, a transportation program helping Veterans get to and from distant VA facilities, a Veteran Resource Center, and a Veteran Tribal Clinic. This program has successfully trained over 800 TVRs, expanded to other parts of the country and into remote areas of Alaska.

  6. An assessment of antimicrobial consumption in food producing animals in Kenya

    DEFF Research Database (Denmark)

    Mitema, E.S.; Kikuvi, G.M.; Wegener, Henrik Caspar;

    2001-01-01

    that the tetracyclines, sulfonamides and trimethoprim, nitrofurans aminoglycosides, P-lactams and the quinolones are the most commonly used drugs in food-producing animals in Kenya. Tetracyclines contributed approximately 55% of the total consumption, and there was an increasing trend in the consumption of quinolones...... to evaluate antimicrobial usage patterns by animal species, route of administration, antimicrobial class and type of use from 1995 to 1999 in Kenya. Theses data are essential for risk analysis and planning and can be helpful in interpreting resistance surveillance data, and evaluating the effectiveness...... of prudent use efforts and antimicrobial resistance mitigation strategies. Data on quantities of active substance classes were collected from the official records of the Pharmacy and Poisons Board of the Ministry of Health and analysed in MS Excel 2000 program. The mean antimicrobial consumption for the 5...

  7. Self-assembly of cationic multidomain peptide hydrogels: supramolecular nanostructure and rheological properties dictate antimicrobial activity.

    Science.gov (United States)

    Jiang, Linhai; Xu, Dawei; Sellati, Timothy J; Dong, He

    2015-12-01

    Hydrogels are an important class of biomaterials that have been widely utilized for a variety of biomedical/medical applications. The biological performance of hydrogels, particularly those used as wound dressing could be greatly advanced if imbued with inherent antimicrobial activity capable of staving off colonization of the wound site by opportunistic bacterial pathogens. Possessing such antimicrobial properties would also protect the hydrogel itself from being adversely affected by microbial attachment to its surface. We have previously demonstrated the broad-spectrum antimicrobial activity of supramolecular assemblies of cationic multi-domain peptides (MDPs) in solution. Here, we extend the 1-D soluble supramolecular assembly to 3-D hydrogels to investigate the effect of the supramolecular nanostructure and its rheological properties on the antimicrobial activity of self-assembled hydrogels. Among designed MDPs, the bactericidal activity of peptide hydrogels was found to follow an opposite trend to that in solution. Improved antimicrobial activity of self-assembled peptide hydrogels is dictated by the combined effect of supramolecular surface chemistry and storage modulus of the bulk materials, rather than the ability of individual peptides/peptide assemblies to penetrate bacterial cell membrane as observed in solution. The structure-property-activity relationship developed through this study will provide important guidelines for designing biocompatible peptide hydrogels with built-in antimicrobial activity for various biomedical applications.

  8. Effects of hydrophobicity on the antifungal activity of alpha-helical antimicrobial peptides.

    NARCIS (Netherlands)

    Jiang, Z.; Kullberg, B.J.; Lee, H van der; Vasil, A.I.; Hale, J.D.; Mant, C.T.; Hancock, R.E.; Vasil, M.L.; Netea, M.G.; Hodges, R.S.

    2008-01-01

    We utilized a series of analogs of D-V13K (a 26-residue amphipathic alpha-helical antimicrobial peptide, denoted D1) to compare and contrast the role of hydrophobicity on antifungal and antibacterial activity to the results obtained previously with Pseudomonas aeruginosa strains. Antifungal activity

  9. Antidiarrheal and antimicrobial profiles extracts of the leaves from Trichilia emetica Vahl. (Meliaceae

    Directory of Open Access Journals (Sweden)

    Kiessoun Konaté

    2015-03-01

    Conclusions: The obtained results allow justifying the traditional uses of Trichilia emetica and possess good antidiarrhoeal and antimicrobial activities of EAF from Trichilia emetica. Results of the present study have clearly supported the utilization of Trichilia emetica in Burkina Faso traditional medicine.

  10. A systems biology approach to investigate the antimicrobial activity of oleuropein

    Science.gov (United States)

    Oleuropein and its hydrolysis products are olive phenolic compounds that have antimicrobial effects on a variety of pathogens, with the potential to be utilized in food and pharmaceutical products. While the existing research is mainly focused on individual genes or enzymes that are regulated by ole...

  11. Study of the impacts of regulations affecting the acceptance of Integrated Community Energy Systems: public utility, energy facility siting and municipal franchising regulatory programs in Maryland. Preliminary background report

    Energy Technology Data Exchange (ETDEWEB)

    Feurer, D A; Weaver, C L; Gallagher, K C; Hejna, D; Rielley, K J

    1980-01-01

    The authority to regulate public utilities in Maryland is vested in the Public Service Commission under the authority of the Public Service Commission Law. The Commission consists of five commissioners who are appointed by the governor with the advice and consent of the Senate. Commissioners must be or become citizens of Maryland, at least three are to serve full time, and one of the commissioners is to be nominated as chairman. The tenure of each commissioner is six years and their terms are on a staggered schedule. Commissioners are eligible for reappointment. The Public Service Commission Law provides that the Commission's powers an jurisdiction shall extend to the full extent permitted by the Constitution and laws of the United States. Local governments in Maryland are not given regulatory power over public service companies. The only power that local governments have over the operations of utilities is the power to grant franchises. Public utility regulatory statutes, energy facility siting programs, and municipal franchising authority are examined to identify how they may impact on the ability of an organization, whether or not it be a regulated utility, to construct and operate an ICES.

  12. Cholic acid derivatives: novel antimicrobials.

    Science.gov (United States)

    Savage, P B; Li, C

    2000-02-01

    Mimics of squalamine and polymyxin B (PMB) have been prepared from cholic acid in hope of finding new antimicrobial agents. The squalamine mimics include the polyamine and sulphate functionalities found in the parent antibiotic, however, the positions relative to the steroid nucleus have been exchanged. The PMB mimics include the conservation of functionality among the polymyxin family of antibiotics, the primary amine groups and a hydrophobic chain. Although the squalamine and PMB mimics are morphologically dissimilar, they display similar activities. Both are simple to prepare and demonstrate broad spectrum antimicrobial activity against Gram-negative and Gram-positive organisms. Specific examples may be inactive alone, yet effectively permeabilise the outer membranes of Gram-negative bacteria rendering them sensitive to hydrophobic antibiotics. Problems associated with some of the squalamine and PMB mimics stem from their haemolytic activity and interactions with serum proteins, however, examples exist without these side effects which can sensitise Gram-negative bacteria to hydrophobic antibiotics. PMID:11060676

  13. Antimicrobial peptides in the brain.

    Science.gov (United States)

    Su, Yanhua; Zhang, Kai; Schluesener, Hermann J

    2010-10-01

    Antimicrobial peptides (AMPs) are an evolutionarily conserved component of the innate immune system of many species. The brain is an immunologically privileged organ but can produce a robust immune response against pathogens and cell debris, promoting rapid and efficient clearance. AMPs may be critically involved in the innate immune system of the brain. Though the mechanisms of AMPs' action in the brain still need further elucidation, many studies have shown that AMPs are multifunctional molecules in the brain. In addition to antimicrobial action, they take part in congenital and adaptive immune reactions (immunoregulation), function as signaling molecules in tissue repair, inflammation and other important processes through different mechanisms, and they might, in addition, become diagnostic markers of brain disease.

  14. Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms.

    Science.gov (United States)

    Ahmad, Aqeel; Azmi, Sarfuddin; Srivastava, Saurabh; Kumar, Amit; Tripathi, Jitendra Kumar; Mishra, Nripendra N; Shukla, Praveen K; Ghosh, Jimut Kanti

    2014-11-01

    Design of antimicrobial peptides with selective activity towards microorganisms is an important step towards the development of new antimicrobial agents. Leucine zipper sequence has been implicated in cytotoxic activity of naturally occurring antimicrobial peptides; moreover, this motif has been utilized for the design of novel antimicrobial peptides with modulated cytotoxicity. To understand further the impact of substitution of amino acids at 'a' and/or 'd' position of a leucine zipper sequence of an antimicrobial peptides on its antimicrobial and cytotoxic properties four short peptides (14-residue) were designed on the basis of a leucine zipper sequence without or with replacement of leucine residues in its 'a' and 'd' positions with D-leucine or alanine or proline residue. The original short leucine zipper peptide (SLZP) and its D-leucine substituted analog, DLSA showed comparable activity against the tested Gram-positive and negative bacteria and the fungal strains. The alanine substituted analog (ASA) though showed appreciable activity against the tested bacteria, it showed to some extent lower activity against the tested fungi. However, the proline substituted analog (PSA) showed lower activity against the tested bacterial or fungal strains. Interestingly, DLSA, ASA and PSA showed significantly lower cytotoxicity than SLZP against both human red blood cells (hRBCs) and murine 3T3 cells. Cytotoxic and bactericidal properties of these peptides matched with peptide-induced damage/permeabilization of mammalian cells and bacteria or their mimetic lipid vesicles suggesting cell membrane could be the target of these peptides. As evidenced by tryptophan fluorescence and acrylamide quenching studies the peptides showed similarities either in interaction or in their localization within the bacterial membrane mimetic negatively charged lipid vesicles. Only SLZP showed localization inside the mammalian membrane mimetic zwitterionic lipid vesicles. The results show

  15. A European study on the relationship between antimicrobial use and antimicrobial resistance

    NARCIS (Netherlands)

    Bronzwaer, SLAM; Cars, O; Buchholz, U; Molstad, S; Goettsch, W; Veldhuijzen, IK; Kool, JL; Sprenger, MJW; Degener, JE

    2002-01-01

    In Europe, antimicrobial resistance has been monitored since 1998 by the European Antimicrobial Resistance Surveillance System (EARSS). We examined the relationship between penicillin nonsusceptibility of invasive isolates of Streptococcus pneumoniae and antibiotic sales. Information was collected o

  16. Antimicrobial activities of squalamine mimics.

    OpenAIRE

    Kikuchi, K.; Bernard, E M; Sadownik, A; Regen, S L; Armstrong, D

    1997-01-01

    We investigated the antimicrobial properties of compounds with structural features that were designed to mimic those of squalamine, an antibiotic isolated from the stomach of the dogfish shark. The mimics, like squalamine, are sterol-polyamine conjugates. Unlike squalamine, the mimics were simple to prepare, at high yield, from readily available starting materials. Several squalamine mimics showed activity against gram-negative rods, gram-positive cocci including methicillin-resistant Staphyl...

  17. Curriculum Evaluation and Revision in a Nascent Field: The Utility of the Retrospective Pretest-Posttest Model in a Homeland Security Program of Study

    Science.gov (United States)

    Pelfrey, William V., Sr.; Pelfrey, William V., Jr.

    2009-01-01

    Although most academic disciplines evolve at a measured pace, the emerging field of homeland security must, for reasons of safety and security, evolve rapidly. The Department of Homeland Security sponsored the establishment of a graduate educational program for key officials holding homeland security roles. Because homeland security is a nascent…

  18. Utilizing the RE-AIM Framework in formative evaluation and program planning for a healthy food choice intervention in the Lower Mississippi Delta

    Science.gov (United States)

    A robust approach to program planning is needed for the development and execution of effective and sustainable behavioral interventions with large public health impact. The purpose of this formative research was to apply dimensions of the RE-AIM (i.e., Reach, Effectiveness, Adoption, Implementation,...

  19. Antimicrobial hydrogels for the treatment of infection.

    Science.gov (United States)

    Veiga, Ana Salomé; Schneider, Joel P

    2013-11-01

    The increasing prevalence of microbial infections, especially those associated with impaired wound healing and biomedical implant failure has spurred the development of new materials having antimicrobial activity. Hydrogels are a class of highly hydrated material finding use in diverse medical applications such as drug delivery, tissue engineering, as wound fillers, and as implant coatings, to name a few. The biocompatible nature of many gels make them a convenient starting platform to develop selectively active antimicrobial materials. Hydrogels with antimicrobial properties can be obtained through the encapsulation or covalent immobilization of known antimicrobial agents, or the material itself can be designed to possess inherent antimicrobial activity. In this review we present an overview of antimicrobial hydrogels that have recently been developed and when possible provide a discussion relevant to their mechanism of action.

  20. Collagen-like antimicrobial peptides.

    Science.gov (United States)

    Masuda, Ryo; Kudo, Masakazu; Dazai, Yui; Mima, Takehiko; Koide, Takaki

    2016-11-01

    Combinatorial library composed of rigid rod-like peptides with a triple-helical scaffold was constructed. The component peptides were designed to have various combinations of basic and neutral (or hydrophobic) amino acid residues based on collagen-like (Gly-Pro-Yaa)-repeating sequences, inspired from the basic and amphiphilic nature of naturally occurring antimicrobial peptides. Screening of the peptide pools resulted in identification of antimicrobial peptides. A structure-activity relationship study revealed that the position of Arg-cluster at N-terminus and cystine knots at C-terminus in the triple helix significantly contributed to the antimicrobial activity. The most potent peptide RO-A showed activity against Gram-negative Escherichia coli and Gram-positive Bacillus subtilis. In addition, Escherichia coli exposed to RO-A resulted in abnormal elongation of the cells. RO-A was also shown to have remarkable stability in human serum and low cytotoxicity to mammalian cells. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 453-459, 2016. PMID:27271210