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Sample records for answers cancer nanotechnology

  1. Nanotechnology for cancer treatment

    OpenAIRE

    Gmeiner, William H.; Ghosh, Supratim

    2013-01-01

    Nanotechnology has the potential to increase the selectivity and potency of chemical, physical, and biological approaches for eliciting cancer cell death while minimizing collateral toxicity to nonmalignant cells. Materials on the nanoscale are increasingly being targeted to cancer cells with great specificity through both active and passive targeting. In this review, we summarize recent literature that has broken new ground in the use of nanotechnology for cancer treatment with an emphasis o...

  2. Strategic Workshops on Cancer Nanotechnology

    OpenAIRE

    Nagahara, Larry A.; Lee, Jerry S.H.; Molnar, Linda K.; Panaro, Nicholas J.; Farrell, Dorothy; Ptak, Krzysztof; Alper, Joseph; Grodzinski, Piotr

    2010-01-01

    Nanotechnology offers the potential for new approaches to detecting, treating and preventing cancer. To determine the current status of the cancer nanotechnology field and the optimal path forward, the National Cancer Institute’s Alliance for Nanotechnology in Cancer held three strategic workshops, covering the areas of in-vitro diagnostics and prevention, therapy and post-treatment, and in-vivo diagnosis and imaging. At each of these meetings, a wide range of experts from academia, industry,...

  3. Nanotechnology for breast cancer therapy.

    Science.gov (United States)

    Tanaka, Takemi; Decuzzi, Paolo; Cristofanilli, Massimo; Sakamoto, Jason H; Tasciotti, Ennio; Robertson, Fredika M; Ferrari, Mauro

    2009-02-01

    Breast cancer is the field of medicine with the greatest presence of nanotechnological therapeutic agents in the clinic. A pegylated form of liposomally encapsulated doxorubicin is routinely used for treatment against metastatic cancer, and albumin nanoparticulate chaperones of paclitaxel were approved for locally recurrent and metastatic disease in 2005. These drugs have yielded substantial clinical benefit, and are steadily gathering greater beneficial impact. Clinical trials currently employing these drugs in combination with chemo and biological therapeutics exceed 150 worldwide. Despite these advancements, breast cancer morbidity and mortality is unacceptably high. Nanotechnology offers potential solutions to the historical challenge that has rendered breast cancer so difficult to contain and eradicate: the extreme biological diversity of the disease presentation in the patient population and in the evolutionary changes of any individual disease, the multiple pathways that drive disease progression, the onset of 'resistance' to established therapeutic cocktails, and the gravity of the side effects to treatment, which result from generally very poor distribution of the injected therapeutic agents in the body. A fundamental requirement for success in the development of new therapeutic strategies is that breast cancer specialists-in the clinic, the pharmaceutical and the basic biological laboratory-and nanotechnologists-engineers, physicists, chemists and mathematicians-optimize their ability to work in close collaboration. This further requires a mutual openness across cultural and language barriers, academic reward systems, and many other 'environmental' divides. This paper is respectfully submitted to the community to help foster the mutual interactions of the breast cancer world with micro- and nano-technology, and in particular to encourage the latter community to direct ever increasing attention to breast cancer, where an extraordinary beneficial impact may

  4. Emerging nanotechnologies for cancer immunotherapy.

    Science.gov (United States)

    Shukla, Sourabh; Steinmetz, Nicole F

    2016-05-01

    Founded on the growing insight into the complex cancer-immune system interactions, adjuvant immunotherapies are rapidly emerging and being adapted for the treatment of various human malignancies. Immune checkpoint inhibitors, for example, have already shown clinical success. Nevertheless, many approaches are not optimized, require frequent administration, are associated with systemic toxicities and only show modest efficacy as monotherapies. Nanotechnology can potentially enhance the efficacy of such immunotherapies by improving the delivery, retention and release of immunostimulatory agents and biologicals in targeted cell populations and tissues. This review presents the current status and emerging trends in such nanotechnology-based cancer immunotherapies including the role of nanoparticles as carriers of immunomodulators, nanoparticles-based cancer vaccines, and depots for sustained immunostimulation. Also highlighted are key translational challenges and opportunities in this rapidly growing field.

  5. Nanotechnology for Early Cancer Detection

    Directory of Open Access Journals (Sweden)

    Joon Won Park

    2010-01-01

    Full Text Available Vast numbers of studies and developments in the nanotechnology area have been conducted and many nanomaterials have been utilized to detect cancers at early stages. Nanomaterials have unique physical, optical and electrical properties that have proven to be very useful in sensing. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon nanotubes, gold nanowires and many other materials have been developed over the years, alongside the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. Proteins, antibody fragments, DNA fragments, and RNA fragments are the base of cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future, we might be able to detect cancer at a very early stage, providing a much higher chance of treatment.

  6. Best practices in cancer nanotechnology: perspective from NCI nanotechnology alliance.

    Science.gov (United States)

    Zamboni, William C; Torchilin, Vladimir; Patri, Anil K; Hrkach, Jeff; Stern, Stephen; Lee, Robert; Nel, Andre; Panaro, Nicholas J; Grodzinski, Piotr

    2012-06-15

    Historically, treatment of patients with cancer using chemotherapeutic agents has been associated with debilitating and systemic toxicities, poor bioavailability, and unfavorable pharmacokinetics. Nanotechnology-based drug delivery systems, on the other hand, can specifically target cancer cells while avoiding their healthy neighbors, avoid rapid clearance from the body, and be administered without toxic solvents. They hold immense potential in addressing all of these issues, which has hampered further development of chemotherapeutics. Furthermore, such drug delivery systems will lead to cancer therapeutic modalities that are not only less toxic to the patient but also significantly more efficacious. In addition to established therapeutic modes of action, nanomaterials are opening up entirely new modalities of cancer therapy, such as photodynamic and hyperthermia treatments. Furthermore, nanoparticle carriers are also capable of addressing several drug delivery problems that could not be effectively solved in the past and include overcoming formulation issues, multidrug-resistance phenomenon, and penetrating cellular barriers that may limit device accessibility to intended targets, such as the blood-brain barrier. The challenges in optimizing design of nanoparticles tailored to specific tumor indications still remain; however, it is clear that nanoscale devices carry a significant promise toward new ways of diagnosing and treating cancer. This review focuses on future prospects of using nanotechnology in cancer applications and discusses practices and methodologies used in the development and translation of nanotechnology-based therapeutics. PMID:22669131

  7. DNA Nanotechnology for Cancer Therapy

    OpenAIRE

    Kumar, Vinit; Palazzolo, Stefano; Bayda, Samer; Corona, Giuseppe; Toffoli, Giuseppe; Rizzolio, Flavio

    2016-01-01

    DNA nanotechnology is an emerging and exciting field, and represents a forefront frontier for the biomedical field. The specificity of the interactions between complementary base pairs makes DNA an incredible building material for programmable and very versatile two- and three-dimensional nanostructures called DNA origami. Here, we analyze the DNA origami and DNA-based nanostructures as a drug delivery system. Besides their physical-chemical nature, we dissect the critical factors such as sta...

  8. Carbon nanotubes for in vivo cancer nanotechnology

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The latest progress of using carbon nanotubes(CNTs) for in vivo cancer nanotechnology is reviewed.CNTs can be functionalized by either covalent or non-covalent chemistry to produce functional bioconjugates for many in vivo applications.In vivo behaviors and toxicology studies of CNTs are summarized,suggesting no significant toxicity of well functionalized CNTs to the treated mice.Owing to their unique chemical and physical properties,CNTs,especially single-walled carbon nanotubes(SWNTs),have been widely used for various modalities of in vivo cancer treatment and imaging.Future development of CNT-based nanomedicine may bring novel opportunities to cancer diagnosis and therapy.

  9. Application of nanotechnology in cancers prevention, early detection and treatment

    Directory of Open Access Journals (Sweden)

    Shraddha P Patel

    2014-01-01

    Full Text Available Use of nanotechnology in medical science is a rapidly developing area. New opportunities of diagnosis, imaging and therapy have developed due to recent rapid advancement by nanotechnology. The most common areas to be affected are diagnostic, imaging and targeted drug delivery in gastroenterology, oncology, cardiovascular medicine, obstetrics and gynecology. Mass screening with inexpensive imaging might be possible in the near future with the help of nanotechnology. This review paper provides an overview of causes of cancer and the application of nanotechnology in cancer prevention, detection and treatment.

  10. NANOTECHNOLOGY IN THE TREATMENT AND DETECTION OF INTRAOCULAR CANCERS

    OpenAIRE

    Nair, Ashwin; Thevenot, Paul; Hu, Wenjing; Tang, Liping

    2008-01-01

    Tremendous progress in nanotechnology has lead to the development of nanometer-sized objects as medical implants or devices. Many of these nanodevices have recently been tested in many cancer diagnostic and therapeutic applications, such as leukemia, melanoma, breast tumor, prostate tumor, and brain cancer. Despite the increasing importance of nanotechnology in cancer, the potential of these nanodevices in diagnosing and treating intraocular cancers has not been systematically evaluated. This...

  11. Applications of gold nanoparticles in cancer nanotechnology

    Directory of Open Access Journals (Sweden)

    Weibo Cai

    2008-09-01

    Full Text Available Weibo Cai1,2, Ting Gao3, Hao Hong1, Jiangtao Sun11Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin – Madison, Madison, Wisconsin, USA; 2University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, USA; 3Tyco Electronics Corporation, 306 Constitution Drive, Menlo Park, California, USAAbstract: It has been almost 4 decades since the “war on cancer” was declared. It is now generally believed that personalized medicine is the future for cancer patient management. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of cancer, nanoparticles have been extensively studied over the last decade. In this review, we will summarize the current state-of-the-art of gold nanoparticles in biomedical applications targeting cancer. Gold nanospheres, nanorods, nanoshells, nanocages, and surface enhanced Raman scattering nanoparticles will be discussed in detail regarding their uses in in vitro assays, ex vivo and in vivo imaging, cancer therapy, and drug delivery. Multifunctionality is the key feature of nanoparticle-based agents. Targeting ligands, imaging labels, therapeutic drugs, and other functionalities can all be integrated to allow for targeted molecular imaging and molecular therapy of cancer. Big strides have been made and many proof-of-principle studies have been successfully performed. The future looks brighter than ever yet many hurdles remain to be conquered. A multifunctional platform based on gold nanoparticles, with multiple receptor targeting, multimodality imaging, and multiple therapeutic entities, holds the promise for a “magic gold bullet” against cancer.Keywords: gold nanoparticles, cancer, nanotechnology, optical imaging, nanomedicine, molecular therapy

  12. Diagnosis of prostate cancer via nanotechnological approach

    Directory of Open Access Journals (Sweden)

    Kang BJ

    2015-10-01

    Full Text Available Benedict J Kang,1,2,* Minhong Jeun,1,2,* Gun Hyuk Jang,1,2 Sang Hoon Song,3 In Gab Jeong,3 Choung-Soo Kim,3 Peter C Searson,4 Kwan Hyi Lee1,2 1KIST Biomedical Research Institute, 2Department of Biomedical Engineering, Korea University of Science and Technology (UST, 3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 4Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA *These authors contributed equally to this work Abstract: Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.Keywords: bioassay, nanomaterial, nanodevice, PSA, non-PSA biomarker, bodily fluid

  13. NCI Alliance for Nanotechnology in Cancer - Tutorials and Seminar Series

    Science.gov (United States)

    View details about tutorials and seminars hosted by Alliance members and members of the cancer research community. These events provide a forum for sharing innovative perspectives on research and development efforts in the field of nanotechnology and their application to cancer diagnosis, treatment, and prevention. Also visit the Event Listing section to find scientific meetings and events where NCI Alliance for Nanotechnology in Cancer leaders and members are participating.

  14. The role of nanotechnology in cancer treatment and diagnosis

    OpenAIRE

    Teixeira, Vanessa Micaela dos Santos; Silva, Ana Catarina; Lopes, Carla Martins

    2010-01-01

    Cancer treatment is one of the major challenges of modern medicine. Several attempts have been made, in order to find more successful treatments. Nanotechnology can be applied to target drugs to the surface or to the interior of specific cells. In addition, it can also be used in diagnosis and prognosis of diseases. Therefore, nanotechnology opened a new vast exploiting area for cancer treatment. The studies must go on to obtain tailor-made therapies, with low adverse side effe...

  15. Overcoming multidrug resistance(MDR) in cancer by nanotechnology

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) cancer.This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs,deliver chemotherapeutic drugs to target sites,control release of drugs,and reduce the systemic toxicity of drugs in MDR cancer.This review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer.

  16. Best Practices in Cancer Nanotechnology – Perspective from NCI Nanotechnology Alliance

    Science.gov (United States)

    Zamboni, William C.; Torchilin, Vladimir; Patri, Anil; Hrkach, Jeff; Stern, Stephen; Lee, Robert; Nel, Andre; Panaro, Nicholas J.; Grodzinski, Piotr

    2014-01-01

    Historically, treatment of patients with cancer using chemotherapeutic agents has been associated with debilitating and systemic toxicities, poor bioavailability, and unfavorable pharmacokinetics. Nanotechnology-based drug delivery systems, on the other hand, can specifically target cancer cells while avoiding their healthy neighbors, avoid rapid clearance from the body, and be administered without toxic solvents. They hold immense potential in addressing all of these issues which has hampered further development of chemotherapeutics. Furthermore, such drug delivery systems will lead to cancer therapeutic modalities which are not only less toxic to the patient but also significantly more efficacious. In addition to established therapeutic modes of action, nanomaterials are opening up entirely new modalities of cancer therapy, such as photodynamic and hyperthermia treatments. Furthermore, nanoparticle carriers are also capable of addressing several drug delivery problems which could not be effectively solved in the past and include overcoming formulation issues, multi-drug-resistance phenomenon and penetrating cellular barriers that may limit device accessibility to intended targets such as the blood-brain-barrier. The challenges in optimizing design of nanoparticles tailored to specific tumor indications still remain; however, it is clear that nanoscale devices carry a significant promise towards new ways of diagnosing and treating cancer. This review focuses on future prospects of using nanotechnology in cancer applications and discusses practices and methodologies used in the development and translation of nanotechnology-based therapeutics. PMID:22669131

  17. Convergence of nanotechnology and cancer prevention: are we there yet?

    Science.gov (United States)

    Menter, David G; Patterson, Sherri L; Logsdon, Craig D; Kopetz, Scott; Sood, Anil K; Hawk, Ernest T

    2014-10-01

    Nanotechnology is emerging as a promising modality for cancer treatment; however, in the realm of cancer prevention, its full utility has yet to be determined. Here, we discuss the potential of integrating nanotechnology in cancer prevention to augment early diagnosis, precision targeting, and controlled release of chemopreventive agents, reduced toxicity, risk/response assessment, and personalized point-of-care monitoring. Cancer is a multistep, progressive disease; the functional and acquired characteristics of the early precancer phenotype are intrinsically different from those of a more advanced anaplastic or invasive malignancy. Therefore, applying nanotechnology to precancers is likely to be far more challenging than applying it to established disease. Frank cancers are more readily identifiable through imaging and biomarker and histopathologic assessment than their precancerous precursors. In addition, prevention subjects routinely have more rigorous intervention criteria than therapy subjects. Any nanopreventive agent developed to prevent sporadic cancers found in the general population must exhibit a very low risk of serious side effects. In contrast, a greater risk of side effects might be more acceptable in subjects at high risk for cancer. Using nanotechnology to prevent cancer is an aspirational goal, but clearly identifying the intermediate objectives and potential barriers is an essential first step in this exciting journey.

  18. Cancer Nanotechnology Startup Challenge: a new way to realize the fruits of innovation

    OpenAIRE

    Currell, Fred; Bellringer, Mark

    2016-01-01

    A significant new innovation-development model is being launched in the field of cancer and nanotechnology. A significant new innovation-development model is being launched in the field of cancer and nanotechnology.

  19. Highlights of recent developments and trends in cancer nanotechnology research--view from NCI Alliance for Nanotechnology in Cancer.

    Science.gov (United States)

    Hull, L C; Farrell, D; Grodzinski, P

    2014-01-01

    Although the incidence of cancer and cancer related deaths in the United States has decreased over the past two decades due to improvements in early detection and treatment, cancer still is responsible for a quarter of the deaths in this country. There is much room for improvement on the standard treatments currently available and the National Cancer Institute (NCI) has recognized the potential for nanotechnology and nanomaterials in this area. The NCI Alliance for Nanotechnology in Cancer was formed in 2004 to support multidisciplinary researchers in the application of nanotechnology to cancer diagnosis and treatment. The researchers in the Alliance have been productive in generating innovative solutions to some of the central issues of cancer treatment including how to detect tumors earlier, how to target cancer cells specifically, and how to improve the therapeutic index of existing chemotherapies and radiotherapy treatments. Highly creative ideas are being pursued where novelty in nanomaterial development enables new modalities of detection or therapy. This review highlights some of the innovative materials approaches being pursued by researchers funded by the NCI Alliance. Their discoveries to improve the functionality of nanoparticles for medical applications includes the generation of new platforms, improvements in the manufacturing of nanoparticles and determining the underlying reasons for the movement of nanoparticles in the blood.

  20. Nanotechnology for the delivery of phytochemicals in cancer therapy.

    Science.gov (United States)

    Xie, Jing; Yang, Zhaogang; Zhou, Chenguang; Zhu, Jing; Lee, Robert J; Teng, Lesheng

    2016-01-01

    The aim of this review is to summarize advances that have been made in the delivery of phytochemicals for cancer therapy by the use of nanotechnology. Over recent decades, much research effort has been invested in developing phytochemicals as cancer therapeutic agents. However, several impediments to their wide spread use as drugs still have to be overcome. Among these are low solubility, poor penetration into cells, high hepatic disposition, and narrow therapeutic index. Rapid clearance or uptake by normal tissues and wide tissue distribution result in low drug accumulation in the target tumor sites can result in undesired drug exposure in normal tissues. Association with or encapsulation in nanoscale drug carriers is a potential strategy to address these problems. This review discussed lessons learned on the use of nanotechnology for delivery of phytochemicals that been tested in clinical trials or are moving towards the clinic. PMID:27071534

  1. DETECTION OF CANCER BIOMARKERS WITH NANOTECHNOLOGY

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2013-01-01

    Full Text Available Early detection of cancer biomarkers with high precision is critically important for cancer therapy. A variety of sensors based on different nanostructured materials have attracted intensive research interest due to their potential for highly sensitive and selective detection of cancer biomarkers. This review covers the use of a variety of nanostructured materials, including carbon nanotubes, silicon nanowires, gold nanoparticles and quantum dots, in the fabrication of sensors. Emphases are placed on how the detection systems work and what detection limits can be achieved. Some assays described in this review outperform established methods for cancer biomarker detection. It is highly promising that these sensors would soon move into commercial-scale production and find routine use in hospitals.

  2. Nanotechnology-based intelligent drug design for cancer metastasis treatment.

    Science.gov (United States)

    Gao, Yu; Xie, Jingjing; Chen, Haijun; Gu, Songen; Zhao, Rongli; Shao, Jingwei; Jia, Lee

    2014-01-01

    Traditional chemotherapy used today at clinics is mainly inherited from the thinking and designs made four decades ago when the Cancer War was declared. The potency of those chemotherapy drugs on in-vitro cancer cells is clearly demonstrated at even nanomolar levels. However, due to their non-specific effects in the body on normal tissues, these drugs cause toxicity, deteriorate patient's life quality, weaken the host immunosurveillance system, and result in an irreversible damage to human's own recovery power. Owing to their unique physical and biological properties, nanotechnology-based chemotherapies seem to have an ability to specifically and safely reach tumor foci with enhanced efficacy and low toxicity. Herein, we comprehensively examine the current nanotechnology-based pharmaceutical platforms and strategies for intelligent design of new nanomedicines based on targeted drug delivery system (TDDS) for cancer metastasis treatment, analyze the pros and cons of nanomedicines versus traditional chemotherapy, and evaluate the importance that nanomaterials can bring in to significantly improve cancer metastasis treatment.

  3. Biology of cancer: some questions to answer.

    Science.gov (United States)

    Chapekar, T

    2001-10-01

    Though great advances in cancer biology have taken place through these years, some fundamental questions are still to be explained. Some observations in this regard are discussed in the present paper. In the course of experimental studies on hormonal stimulation of target cells, it was observed that goat granulosa cells showed differential proliferative response to sustained stimulation by oLH and hCG in culture. oLH caused cells to proliferate whereas hCG failed to stimulate the cells though both the gonadotropins have common receptors on the target cell. Further studies might throw some light on the mechanism of signal transduction in cell biology and neoplasia. A question is also posed as to how to interpret thermodynamically the sustained growth of cancer vis-a-vis the host.

  4. Unique roles of nanotechnology in medicine and cancer-II

    Directory of Open Access Journals (Sweden)

    F Alam

    2015-01-01

    Full Text Available Applications of nanotechnology in medicine and cancer are becoming increasingly popular. Common nanomaterials and devices applicable in cancer medicine are classifiable as liposomes, polymeric-micelles, dendrimers, nano-cantilevers, carbon nanotubes, quantum dots, magnetic-nanoparticles, gold nanoparticles (AuNPs and certain miscellaneous nanoparticles. Here, we present review of the structure, function and utilities of the various approved, under trial and pretrial nanodevices applicable in the cancer care and medicine. The liposomes are phospholipid-vesicles made use in carrying drugs to the target site minimizing the bio-distribution toxicity and a number of such theranostics have been approved for clinical practice. Newly worked out liposomes and polymeric micelles are under the trail phases for nano-therapeutic utility. A multifunctional dendrimer conjugate with imaging, targeting and drug molecules of paclitaxel has been recently synthesized for cancer theranostic applications. Nano-cantilever based assays are likely going to replace the conventions methods of chemical pathological investigations. Carbon nanotubes are emerging for utility in regenerative and cancer medicine. Quantum dots hold great promise for the micro-metastasis and intra-operative tumor imaging. Important applications of magnetic nanoparticles are in the cardiac stents, photodynamic therapy and liver metastasis imaging. The AuNPs have been employed for cell imaging, computed tomography and cancer therapy. Besides these categories, miscellaneous other nanoparticles are being discovered for utility in the cancer diagnosis and disease management. However, the use of nanoparticles should be cautious since the toxic effects of nanoparticles are not well-known. The use of nanoparticles in the clinical practice and their toxicity profile require further extensive research.

  5. Nanotechnology; its significance in cancer and photodynamic therapy

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Gaeeni

    2015-07-01

    Full Text Available In the last decade, developments in nanotechnology have provided a new field in medicine called “Nanomedicine”. Nanomedicine has provided new tools for photodynamic therapy. Quantum dots (QDs are approximately spherical nanoparticles that have attracted broad attention and have been used in nanomedicine applications. QDs have high molar extinction coefficients and photoluminescence quantum yield, narrow emission spectra, broad absorption, large effective stokes shifts. QDs are more photostable and resistant to metabolic degradation. These photosensitizing properties can be used as photosensitizers for Photodynamic Therapy (PDT. PDT has been recommended for its unique characteristic, such as low side effect and more efficiency. Therefore, nanomedicine leads a promising future for targeted therapy in cancer tumor. Furthermore, QDs have recently been applied in PDT, which will be addressed in this review letter. Also this review letter evaluates key aspects of nano-particulate design and engineering, including the advantage of the nanometer scale size range, biological behavior, and safety profile.

  6. Gazelles, unicorns, and dragons battle cancer through the Nanotechnology Startup Challenge

    OpenAIRE

    Truman, Rosemarie; Locke, Cody J.

    2016-01-01

    On March 4th, 2016, Springer’s Cancer Nanotechnology office promoted the launch of the Nanotechnology Startup Challenge in Cancer (NSC 2 ). This innovation-development model is a partnership among our company, the Center for Advancing Innovation (CAI), MedImmune, the global biologics arm of AstraZeneca, and multiple institutes at the National Institutes of Health (NIH). NSC 2 “crowdsources” talent from around the world to launch startups with near-term, commercially viable cancer nanotechnolo...

  7. Review of "Cancer Nanotechnology: Methods and Protocols (Methods in Molecular Biology" by Stephen R. Grobmyer (Editor, Brij M. Moudgil (Editor

    Directory of Open Access Journals (Sweden)

    Steinmetz Nicole F

    2010-09-01

    Full Text Available Abstract Cancer remains one of the leading causes of death. Research and resulting technologies have contributed to rising numbers of cancer survivors. Cancer nanotechnology is a novel and burgeoning field with the promise to open the door for the development of improved cancer therapies and detection methods. Cancer nanotechnology has the potential to become clinical reality.

  8. Nanotechnological carriers for cancer chemotherapy: the state of the art.

    Science.gov (United States)

    Estanqueiro, Marilene; Amaral, Maria Helena; Conceição, Jaime; Sousa Lobo, José Manuel

    2015-02-01

    Cancer is a term used for a heterogeneous group of malignant diseases in which abnormal cells divide without control and are able to invade other tissues, resulting in metastasis. According to the last data of World Health Organization the incidence and mortality rates of cancer are high and tend to increase. Chemotherapy is usually used in cancer treatments, but due to the lack of specificity of drugs, is associated to various and damaging side effects that have a severe impact on patients quality of life. Nanotechnology is actually an important area of interest in science and technology, which has been extensively explored during the last decade, particularly in the development of carriers for cytotoxic drugs. These carriers include vesicular and particulate systems such as liposomes, niosomes, transfersomes, ethosomes, micelles, dendrimers, and polymeric, protein and lipid nanoparticles. Polymer-drug conjugates and antibody-drug conjugates have also been studied. The present review is an attempt to contemplate the studied nanocarriers in the field of anticancer drugs delivery, their advantages and disadvantages and future perspectives. PMID:25591851

  9. Application of nanotechnology in cancers prevention, early detection and treatment

    OpenAIRE

    Shraddha P Patel; Parshottambhai B Patel; Parekh, Bhavesh B.

    2014-01-01

    Use of nanotechnology in medical science is a rapidly developing area. New opportunities of diagnosis, imaging and therapy have developed due to recent rapid advancement by nanotechnology. The most common areas to be affected are diagnostic, imaging and targeted drug delivery in gastroenterology, oncology, cardiovascular medicine, obstetrics and gynecology. Mass screening with inexpensive imaging might be possible in the near future with the help of nanotechnology. This review paper provides ...

  10. Center of nanotechnology for cancer diagnosis and treatment launched in Tianjin

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ On 24 August, a center of nanotechnology for cancer diagnosis and treatment was officially inaugurated in Tianjin. The center was jointly established by the CAS Institute of High-energy Physics, the CAS affiliated National Center for Nanoscience and Technology, and the Tianjin Medical University Cancer Institute and Hospital.

  11. Application of nanotechnology in the treatment and diagnosis of gastrointestinal cancers: review of recent patents.

    Science.gov (United States)

    Prados, Jose; Melguizo, Consolacion; Perazzoli, Gloria; Cabeza, Laura; Carrasco, Esther; Oliver, Jaime; Jiménez-Luna, Cristina; Leiva, Maria C; Ortiz, Raúl; Álvarez, Pablo J; Aranega, Antonia

    2014-01-01

    Gastrointestinal cancers remain one of the main causes of death in developed countries. The main obstacles to combating these diseases are the limitations of current diagnostic techniques and the low stability, availability, and/or specificity of pharmacological treatment. In recent years, nanotechnology has revolutionized many fields of medicine, including oncology. The association of chemotherapeutic agents with nanoparticles offers improvement in the solubility and stability of antitumor agents, avoidance of drug degradation, and reductions in therapeutic dose and toxicity, increasing drug levels in tumor tissue and decreasing them in healthy tissue. The use of specific molecules that drive nanoparticles to the tumor tissue represents a major advance in therapeutic specificity. In addition, the use of nanotechnology in contrast agents has yielded improvements in the diagnosis and the follow-up of tumors. These nanotechnologies have all been applied in gastrointestinal cancer treatment, first in vitro, and subsequently in vivo, with promising results reported in some clinical trials. A large number of patents have been generated by nanotechnology research over recent years. The objective of this paper is to review patents on the clinical use of nanoparticles for gastrointestinal cancer diagnosis and therapy and to offer an overview of the impact of nanotechnology on the management of this disease.

  12. Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy.

    Science.gov (United States)

    Piktel, Ewelina; Niemirowicz, Katarzyna; Wątek, Marzena; Wollny, Tomasz; Deptuła, Piotr; Bucki, Robert

    2016-01-01

    The rapid development of nanotechnology provides alternative approaches to overcome several limitations of conventional anti-cancer therapy. Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site, became a new standard in novel anti-cancer methods. In effect, the employment of nanoparticles during design of antineoplastic drugs helps to improve pharmacokinetic properties, with subsequent development of high specific, non-toxic and biocompatible anti-cancer agents. However, the physicochemical and biological diversity of nanomaterials and a broad spectrum of unique features influencing their biological action requires continuous research to assess their activity. Among numerous nanosystems designed to eradicate cancer cells, only a limited number of them entered the clinical trials. It is anticipated that progress in development of nanotechnology-based anti-cancer materials will provide modern, individualized anti-cancer therapies assuring decrease in morbidity and mortality from cancer diseases. In this review we discussed the implication of nanomaterials in design of new drugs for effective antineoplastic therapy and describe a variety of mechanisms and challenges for selective tumor targeting. We emphasized the recent advantages in the field of nanotechnology-based strategies to fight cancer and discussed their part in effective anti-cancer therapy and successful drug delivery. PMID:27229857

  13. Potential Applications of Nanotechnology for the Diagnosis and Treatment of Pancreatic Cancer

    Directory of Open Access Journals (Sweden)

    Joshua eMcCarroll

    2014-01-01

    Full Text Available Despite improvements in our understanding of pancreatic cancer and the emerging concept of personalized medicine for the treatment of this disease, it is still the fourth most common cause of cancer death in the western world. It is established that pancreatic cancer is a highly heterogeneous disease with a complex tumor microenvironment. Indeed the extensive stroma surrounding the cancer cells has been shown to be important in promoting tumor growth and metastases, as well as sequestering chemotherapeutic agents consequently decreasing delivery to the tumor cells. Nanotechnology has come to the forefront in the areas of medical diagnostics, imaging, and therapeutic drug delivery. This review will focus on the potential applications of nanotechnology for diagnosis, imaging, and delivery of therapeutic agents for the treatment of pancreatic cancer.

  14. Recent insights in nanotechnology-based drugs and formulations designed for effective anti-cancer therapy

    OpenAIRE

    Piktel, Ewelina; Niemirowicz, Katarzyna; Wątek, Marzena; Wollny, Tomasz; Deptuła, Piotr; Bucki, Robert

    2016-01-01

    The rapid development of nanotechnology provides alternative approaches to overcome several limitations of conventional anti-cancer therapy. Drug targeting using functionalized nanoparticles to advance their transport to the dedicated site, became a new standard in novel anti-cancer methods. In effect, the employment of nanoparticles during design of antineoplastic drugs helps to improve pharmacokinetic properties, with subsequent development of high specific, non-toxic and biocompatible anti...

  15. The Extraordinary Progress in Very Early Cancer Diagnosis and Personalized Therapy: The Role of Oncomarkers and Nanotechnology

    OpenAIRE

    Marialuigina Fruscella; Antonio Ponzetto; Annalisa Crema; Guido Carloni

    2016-01-01

    The impact of nanotechnology on oncology is revolutionizing cancer diagnosis and therapy and largely improving prognosis. This is mainly due to clinical translation of the most recent findings in cancer research, that is, the application of bio- and nanotechnologies. Cancer genomics and early diagnostics are increasingly playing a key role in developing more precise targeted therapies for most human tumors. In the last decade, accumulation of basic knowledge has resulted in a tremendous break...

  16. From nanotechnology to nanomedicine: applications to cancer research.

    Science.gov (United States)

    Seigneuric, R; Markey, L; Nuyten, D S A; Dubernet, C; Evelo, C T A; Finot, E; Garrido, C

    2010-10-01

    Scientific advances have significantly improved the practice of medicine by providing objective and quantitative means for exploring the human body and disease states. These innovative technologies have already profoundly improved disease detection, imaging, treatment and patient follow-up. Today's analytical limits are at the nanoscale level (one-billionth of a meter) enabling a detailed exploration at the level of DNA, RNA, proteins and metabolites which are in fact nano-objects. This translational review aims at integrating some recent advances from micro- and nano-technologies with high potential for improving daily oncology practice.

  17. Nanotechnology in hyperthermia cancer therapy: From fundamental principles to advanced applications.

    Science.gov (United States)

    Beik, Jaber; Abed, Ziaeddin; Ghoreishi, Fatemeh S; Hosseini-Nami, Samira; Mehrzadi, Saeed; Shakeri-Zadeh, Ali; Kamrava, S Kamran

    2016-08-10

    In this work, we present an in-depth review of recent breakthroughs in nanotechnology for hyperthermia cancer therapy. Conventional hyperthermia methods do not thermally discriminate between the target and the surrounding normal tissues, and this non-selective tissue heating can lead to serious side effects. Nanotechnology is expected to have great potential to revolutionize current hyperthermia methods. To find an appropriate place in cancer treatment, all nanotechnology-based hyperthermia methods and their risks/benefits must be thoroughly understood. In this review paper, we extensively examine and compare four modern nanotechnology-based hyperthermia methods. For each method, the possible physical mechanisms of heat generation and enhancement due to the presence of nanoparticles are explained, and recent in vitro and in vivo studies are reviewed and discussed. Nano-Photo-Thermal Therapy (NPTT) and Nano-Magnetic Hyperthermia (NMH) are reviewed as the two first exciting approaches for targeted hyperthermia. The third novel hyperthermia method, Nano-Radio-Frequency Ablation (NaRFA) is discussed together with the thermal effects of novel nanoparticles in the presence of radiofrequency waves. Finally, Nano-Ultrasound Hyperthermia (NUH) is described as the fourth modern method for cancer hyperthermia. PMID:27264551

  18. Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

    Directory of Open Access Journals (Sweden)

    Calixto G

    2014-08-01

    Full Text Available Giovana Calixto, Jéssica Bernegossi, Bruno Fonseca-Santos, Marlus Chorilli School of Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, São Paulo State University (UNESP, São Paulo, Brazil Abstract: Oral cancer (oral cavity and oropharynx is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers. Keywords: targeted delivery, oral squamous cell carcinoma, oral cancer treatment

  19. Impact of nanotechnology on the delivery of natural products for cancer prevention and therapy.

    Science.gov (United States)

    Siddiqui, Imtiaz A; Sanna, Vanna

    2016-06-01

    Chemoprevention of human cancer by dietary products is a practical approach of cancer control, especially when chemoprevention is involved during the early stages of the carcinogenesis process. Research over the last few decades has clearly demonstrated the efficacy of dietary products for chemoprevention in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated to bedside for clinical use. Among many reasons, inefficient systemic delivery and bioavailability of promising chemopreventive agents are considered to significantly contribute to such a disconnection. Since its advent in the field of cancer, nanotechnology has provided researchers with expertise to explore new avenues for diagnosis, prevention, and therapy of the disease. In a similar trait, we introduced a novel concept in which nanotechnology was utilized for enhancing the outcome of chemoprevention (Cancer Res. 2009; 69:1712-1716). This idea, which we termed as 'nanochemoprevention', was exploited by several laboratories and has now become an advancing field in chemoprevention research. This review summarizes some of these applications of nanotechnology in medicine, particularly focused on controlled and sustained release of bioactive compounds with emphasis on current and future utilization of nanochemoprevention for prevention and therapy of cancer. PMID:26935239

  20. Prospects of Bacteriotherapy with Nanotechnology in Nanoparticledrug Conjugation Approach for Cancer Therapy.

    Science.gov (United States)

    Raj, Ritu; Das, Surajit

    2016-01-01

    Bacteriotherapy and nanotechnology have shown remarkable potential in diagnostic and therapeutic applications for various diseases. Individual impacts of these micro-nano systems over different aspects of human health are well studied; however, an integrated system of bacteria-nanoparticle (NP) conjugation is less explored. The untamed potential of bacteria-NP conjugation could be a new tool for diagnosis and treatment of invasive diseases like malaria, tuberculosis and cancer. Mammalian cells exhibit cytosis as their defense mechanism when they encounter foreign elements such as bacteria. In these mammalian cells, during phagocytosis, bacteria are ruptured and lysed by lysozymes. A bacterium carrying the drug-tagged NP would be engulfed in the same manner and ultimately reaches the target cells. Rapid and continuous cell divisions in the cancer tissues lead to defective vessels, underdeveloped cellcell interconnects, development of hypoxic areas and heterogeneous population of tumor cells. This unorganized and poorly developed angiogenesis in tumor cells makes it difficult for conventional chemotherapeutic drugs to localize the tumors selectively. In the present scenario of diagnosis and treatment of cancer/tumor cells, it could be expected that the existing bacteriotherapy with the advanced nanotechnology would be a way further in the targeted drug delivery for cancer therapy. This review emphasizes the potential applications of bacteriotherapy with nanotechnology for the diagnosis and treatment of cancer. PMID:27048378

  1. Nanotechnology: Future of Oncotherapy

    OpenAIRE

    Gharpure, Kshipra M.; Wu, Sherry Y.; Li, Chun; Lopez-Berestein, Gabriel; Sood, Anil K

    2015-01-01

    Recent advances in nanotechnology have established its importance in several areas including medicine. The myriad of applications in oncology range from detection and diagnosis to drug delivery and treatment. Although nanotechnology has attracted a lot of attention, the practical application of nanotechnology to clinical cancer care is still in its infancy. This review summarizes the role that nanotechnology has played in improving cancer therapy, its potential for affecting all aspects of ca...

  2. Nanotechnology-Based Detection and Targeted Therapy in Cancer: Nano-Bio Paradigms and Applications

    Energy Technology Data Exchange (ETDEWEB)

    Mousa, Shaker A., E-mail: shaker.mosua@acphs.edu [The Pharmaceutical Research Institute at Albany College of Pharmacy and Health Sciences, 1 Discovery Drive, Rensselaer, NY 12144 (United States); College of Medicine, King Saud University, Riyadh (Saudi Arabia); Bharali, Dhruba J. [The Pharmaceutical Research Institute at Albany College of Pharmacy and Health Sciences, 1 Discovery Drive, Rensselaer, NY 12144 (United States)

    2011-07-15

    The application of nanotechnology to biomedicine, particularly in cancer diagnosis and treatment, promises to have a profound impact on healthcare. The exploitation of the unique properties of nano-sized particles for cancer therapeutics is most popularly known as nanomedicine. The goals of this review are to discuss the current state of nanomedicine in the field of cancer detection and the subsequent application of nanotechnology to treatment. Current cancer detection methods rely on the patient contacting their provider when they feel ill, or relying on non-specific screening methods, which unfortunately often result in cancers being detected only after it is too late for effective treatment. Cancer treatment paradigms mainly rely on whole body treatment with chemotherapy agents, exposing the patient to medications that non-specifically kill rapidly dividing cells, leading to debilitating side effects. In addition, the use of toxic organic solvents/excipients can hamper the further effectiveness of the anticancer drug. Nanomedicine has the potential to increase the specificity of treatment of cancer cells while leaving healthy cells intact through the use of novel nanoparticles. This review discusses the use of nanoparticles such as quantum dots, nanoshells, nanocrystals, nanocells, and dendrimers for the detection and treatment of cancer. Future directions and perspectives of this cutting-edge technology are also discussed.

  3. Nanotechnology-Based Detection and Targeted Therapy in Cancer: Nano-Bio Paradigms and Applications

    International Nuclear Information System (INIS)

    The application of nanotechnology to biomedicine, particularly in cancer diagnosis and treatment, promises to have a profound impact on healthcare. The exploitation of the unique properties of nano-sized particles for cancer therapeutics is most popularly known as nanomedicine. The goals of this review are to discuss the current state of nanomedicine in the field of cancer detection and the subsequent application of nanotechnology to treatment. Current cancer detection methods rely on the patient contacting their provider when they feel ill, or relying on non-specific screening methods, which unfortunately often result in cancers being detected only after it is too late for effective treatment. Cancer treatment paradigms mainly rely on whole body treatment with chemotherapy agents, exposing the patient to medications that non-specifically kill rapidly dividing cells, leading to debilitating side effects. In addition, the use of toxic organic solvents/excipients can hamper the further effectiveness of the anticancer drug. Nanomedicine has the potential to increase the specificity of treatment of cancer cells while leaving healthy cells intact through the use of novel nanoparticles. This review discusses the use of nanoparticles such as quantum dots, nanoshells, nanocrystals, nanocells, and dendrimers for the detection and treatment of cancer. Future directions and perspectives of this cutting-edge technology are also discussed

  4. Perspectives of Nanotechnology in Minimally Invasive Therapy of Breast Cancer

    Directory of Open Access Journals (Sweden)

    Yamin Yang

    2013-01-01

    Full Text Available Breast cancer, the most common type of cancer among women in the western world, affects approximately one out of every eight women over their lifetime. In recognition of the high invasiveness of surgical excision and severe side effects of chemical and radiation therapies, increasing efforts are made to seek minimally invasive modalities with fewer side effects. Nanoparticles (<100 nm in size have shown promising capabilities for delivering targeted therapeutic drugs to cancer cells and confining the treatment mainly within tumors. Additionally, some nanoparticles exhibit distinct properties, such as conversion of photonic energy into heat, and these properties enable eradication of cancer cells. In this review, current utilization of nanostructures for cancer therapy, especially in minimally invasive therapy, is summarized with a particular interest in breast cancer.

  5. Cancer nanotechnology: a new commercialization pipeline for diagnostics, imaging agents, and therapies

    Science.gov (United States)

    Ptak, Krzysztof; Farrell, Dorothy; Hinkal, George; Panaro, Nicholas J.; Hook, Sara; Grodzinski, Piotr

    2011-06-01

    Nanotechnology - the science and engineering of manipulating matter at the molecular scale to create devices with novel chemical, physical and biological properties - has the potential to radically change oncology. Research sponsored by the NCI Alliance for Nanotechnology in Cancer has led to the development of nanomaterials as platforms of increasing complexity and devices of superior sensitivity, speed and multiplexing capability. Input from clinicians has guided researchers in the design of technologies to address specific needs in the areas of cancer therapy and therapeutic monitoring, in vivo imaging, and in vitro diagnostics. The promising output from the Alliance has led to many new companies being founded to commercialize their nanomedical product line. Furthermore, several of these technologies, which are discussed in this paper, have advanced to clinically testing.

  6. Recent insights into nanotechnology development for detection and treatment of colorectal cancer.

    Science.gov (United States)

    Viswanath, Buddolla; Kim, Sanghyo; Lee, Kiyoung

    2016-01-01

    The global incidence of colorectal cancer (CRC) is 1.3 million cases. It is the third most frequent cancer in males and females. Most CRCs are adenocarcinomas and often begin as a polyp on the inner wall of the rectum or colon. Some of these polyps become malignant, eventually. Detecting and removing these polyps in time can prevent CRC. Therefore, early diagnosis of CRC is advantageous for preventive and instant action interventions to decrease the mortality rates. Nanotechnology has been enhancing different methods for the detection and treatment of CRCs, and the research has provided hope within the scientific community for the development of new therapeutic strategies. This review presents the recent development of nanotechnology for the detection and treatment of CRC. PMID:27330292

  7. Therapeutic Potential of Delivering Arsenic Trioxide into HPV-Infected Cervical Cancer Cells Using Liposomal Nanotechnology

    OpenAIRE

    Wang, Xiaoyan; Li, Dong; Ghali, Lucy; Xia, Ruidong; Munoz, Leonardo P.; Garelick, Hemda; Bell, Celia M.; Wen, Xuesong

    2016-01-01

    Arsenic trioxide (ATO) has been used successfully to treat acute promyelocytic leukaemia, and since this discovery, it has also been researched as a possible treatment for other haematological and solid cancers. Even though many positive results have been found in the laboratory, wider clinical use of ATO has been compromised by its toxicity at higher concentrations. The aim of this study was to explore an improved method for delivering ATO using liposomal nanotechnology to evaluate whether t...

  8. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review.

    Science.gov (United States)

    Calixto, Giovana Maria Fioramonti; Bernegossi, Jéssica; de Freitas, Laura Marise; Fontana, Carla Raquel; Chorilli, Marlus

    2016-01-01

    Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer.

  9. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review.

    Science.gov (United States)

    Calixto, Giovana Maria Fioramonti; Bernegossi, Jéssica; de Freitas, Laura Marise; Fontana, Carla Raquel; Chorilli, Marlus

    2016-01-01

    Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer. PMID:26978341

  10. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

    Directory of Open Access Journals (Sweden)

    Giovana Maria Fioramonti Calixto

    2016-03-01

    Full Text Available Photodynamic therapy (PDT is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs, solid lipid nanoparticles (SLNs, nanostructured lipid carriers (NLCs, gold nanoparticles (AuNPs, hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer.

  11. Exploiting Nanotechnology for the Development of MicroRNA-Based Cancer Therapeutics.

    Science.gov (United States)

    Tyagi, Nikhil; Arora, Sumit; Deshmukh, Sachin K; Singh, Seema; Marimuthu, Saravanakumar; Singh, Ajay P

    2016-01-01

    MicroRNAs (miRNAs/miRs) represent a novel class of small non-coding RNAs that post-transcriptionally regulate gene expression by base pairing with complementary sequences in the 3' untranslated region (UTR) of target mRNAs. Functional studies suggest that miRNAs control almost every biological process, and their aberrant expression leads to a disease state, such as cancer. Differential expression of miRNAs in cancerous versus normal cells have generated enormous interest for the development of miRNA-based cancer cell-targeted therapeutics. Depending on the miRNA function and expression in cancer, two types of miRNA-based therapeutic strategies can be utilized that either restore or inhibit miRNA function through exogenous delivery of miRNAs mimics or inhibitors (anti-miRs). However, hydrophilic nature of miRNA mimics/anti-miRs, sensitivity to nuclease degradation in serum, poor penetration and reduced uptake by the tumor cells are chief hurdles in accomplishing their efficient in vivo delivery. To overcome these barriers, several nanotechnology-based systems are being developed and tested for delivery efficacy. This review summarizes the importance of miRNAs-based therapeutics in cancer, associated translational challenges and novel nanotechnology-assisted delivery systems that hold potential for next-generation miRNA-based cancer therapeutics. PMID:27301170

  12. Bridging cancer biology and the patients' needs with nanotechnology-based approaches.

    Science.gov (United States)

    Fonseca, Nuno A; Gregório, Ana C; Valério-Fernandes, Angela; Simões, Sérgio; Moreira, João N

    2014-06-01

    Cancer remains as stressful condition and a leading cause of death in the western world. Actual cornerstone treatments of cancer disease rest as an elusive alternative, offering limited efficacy with extensive secondary effects as a result of severe cytotoxic effects in healthy tissues. The advent of nanotechnology brought the promise to revolutionize many fields including oncology, proposing advanced systems for cancer treatment. Drug delivery systems rest among the most successful examples of nanotechnology. Throughout time they have been able to evolve as a function of an increased understanding from cancer biology and the tumor microenvironment. Marketing of Doxil® unleashed a remarkable impulse in the development of drug delivery systems. Since then, several nanocarriers have been introduced, with aspirations to overrule previous technologies, demonstrating increased therapeutic efficacy besides decreased toxicity. Spatial and temporal targeting to cancer cells has been explored, as well as the use of drug combinations co-encapsulated in the same particle as a mean to take advantage of synergistic interactions in vivo. Importantly, targeted delivery of siRNA for gene silencing therapy has made its way to the clinic for a "first in man" trial using lipid-polymeric-based particles. Focusing in state-of-the-art technology, this review will provide an insightful vision on nanotechnology-based strategies for cancer treatment, approaching them from a tumor biology-driven perspective, since their early EPR-based dawn to the ones that have truly the potential to address unmet medical needs in the field of oncology, upon targeting key cell subpopulations from the tumor microenvironment. PMID:24613464

  13. Ovarian Cancer: A Clinical Challenge That Needs Some Basic Answers

    OpenAIRE

    CRIJNS, ANNE P.G.; Fehrmann, Rudolf S. N.; Steven de Jong; Frans Gerbens; Gert Jan Meersma; Klip, Harry G.; Harry Hollema; Hofstra, Robert M. W.; te Meerman, Gerard J.; de Vries, Elisabeth G.E.; Ate G J van der Zee

    2009-01-01

    Editors' Summary Background. Ovarian cancer kills more than 100,000 women every year and is one of the most frequent causes of cancer death in women in Western countries. Most ovarian cancers develop when an epithelial cell in one of the ovaries (two small organs in the pelvis that produce eggs) acquires genetic changes that allow it to grow uncontrollably and to spread around the body (metastasize). In its early stages, ovarian cancer is confined to the ovaries and can often be treated succe...

  14. Colorectal cancer in the young, many questions, few answers

    OpenAIRE

    Deen, Kemal I; Silva, Hiroshi; Deen, Raeed; Chandrasinghe, Pramodh C

    2016-01-01

    At a time where the incidence of colorectal cancer, a disease predominantly of developed nations, is showing a decline in those 50 years of age and older, data from the West is showing a rising incidence of this cancer in young individuals. Central to this has been the 75% increase in rectal cancer incidence in the last four decades. Furthermore, predictive data based on mathematical modelling indicates a 124 percent rise in the incidence of rectal cancer by the year 2030 - a statistic that c...

  15. Nanotechnology-based treatment for chemotherapy-resistant breast cancer

    Science.gov (United States)

    Abouzeid, Abraham H.; Patel, Niravkumar R.; Rachman, Ilya M.; Senn, Sean; Torchilin, Vladimir P.

    2014-08-01

    Background: Treatment of metastatic cancer remains a formidable clinical challenge. Better therapeutic options with improved tissue penetration and tumor cell uptake are urgently needed. Targeted nanotherapy, for improved delivery, and combinatory drug administration aimed at inhibiting chemo-resistance may be the solution. Purpose: The study was performed to evaluate the therapeutic efficacy of polymeric PEG-PE micelles, co-loaded with curcumin (CUR) and doxorubicin (DOX), and targeted with anti-GLUT1 antibody (GLUT1) against MDA-MB-231 human breast adenocarcinoma cells both in vitro and in vivo. Methods: MDA-MB-231 DOX-resistant cells were treated with non-targeted and GLUT1-targeted CUR and DOX micelles as a single agent or in combination. Tumor cells were also inoculated in female nude mice. Established tumors were treated with the micellar formulations at a dose of 6 mg/kg CUR and 1 mg/kg DOX every 2 d for a total of 7 injections. Results: CUR+DOX-loaded micelles decorated with GLUT1 had a robust killing effect even at low doses of DOX in vitro. At the doses chosen, non-targeted CUR and CUR+DOX micelles did not exhibit significant tumor inhibition versus control. However, GLUT1-CUR and GLUT1-CUR+DOX micelles showed a significant tumor inhibition effect with an improvement in survival. Conclusion: We showed a dramatic improvement in efficacy between the non-targeted and GLUT1-targeted formulations both in vitro and in vivo. Also, importantly, the addition of CUR to the micelle, has restored sensitivity to DOX, with resultant tumor growth inhibition. Hence, we confirmed that GLUT1-CUR+DOX micelles are effective in vitro and in vivo and deserve further investigation.

  16. Nanotechnology: Future of Oncotherapy.

    Science.gov (United States)

    Gharpure, Kshipra M; Wu, Sherry Y; Li, Chun; Lopez-Berestein, Gabriel; Sood, Anil K

    2015-07-15

    Recent advances in nanotechnology have established its importance in several areas including medicine. The myriad of applications in oncology range from detection and diagnosis to drug delivery and treatment. Although nanotechnology has attracted a lot of attention, the practical application of nanotechnology to clinical cancer care is still in its infancy. This review summarizes the role that nanotechnology has played in improving cancer therapy, its potential for affecting all aspects of cancer care, and the challenges that must be overcome to realize its full promise.

  17. Nanotechnology-based inhalation treatments for lung cancer: state of the art

    Directory of Open Access Journals (Sweden)

    Ahmad J

    2015-11-01

    Full Text Available Javed Ahmad,1,* Sohail Akhter,2,3,* Md Rizwanullah,1 Saima Amin,1 Mahfoozur Rahman,4 Mohammad Zaki Ahmad,5 Moshahid Alam Rizvi,6 Mohammad A Kamal,7 Farhan Jalees Ahmad1,21Department of Pharmaceutics, 2Nanomedicine Research Lab, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India; 3Centre de Biophysique Moléculaire(CBM-CNRS UPR4301, University of Orléans, Orléans Cedex 2, France; 4Department of Pharmaceutics, Abhilashi College of Pharmacy, Mandi, HP, India; 5Department of Pharmaceutics, College of Pharmacy, Najran University, Saudi Arabia; 6Department of Biosciences, Jamia Millia Islamia, New Delhi, India; 7Metabolomics and Enzymology Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia*These authors contributed equally to this workAbstract: Considering the challenges associated with conventional chemotherapy, targeted and local delivery of chemotherapeutics via nanoparticle (NP carriers to the lungs is an emerging area of interest. Recent studies and growing clinical application in cancer nanotechnology showed the huge potential of NPs as drug carriers in cancer therapy, including in lung carcinoma for diagnosis, imaging, and theranostics. Researchers have confirmed that nanotechnology-based inhalation chemotherapy is viable and more effective than conventional chemotherapy, with lesser side effects. Recently, many nanocarriers have been investigated, including liposomes, polymeric micelles, polymeric NPs, solid lipid NPs, and inorganic NPs for inhalation treatments of lung cancer. Yet, the toxicity of such nanomaterials to the lungs tissues and further distribution to other organs due to systemic absorption on inhalation delivery is a debatable concern. Here, prospect of NPs-based local lung cancer targeting through inhalation route as well as its associated challenges are discussed.Keywords: nanoparticles, lung cancer, inhalational chemotherapy, drug targeting, nanotoxicity

  18. 纳米技术在肿瘤治疗中的应用%Nanotechnology applications in cancer therapy

    Institute of Scientific and Technical Information of China (English)

    于小丽; 徐维平; 马旖旎; 王艳萍; 张莉

    2011-01-01

    Nanotechnology, as a leading technology,is recently developed after the information and biotechnology. It has been widely ap plied in the area of cancer diagnosis and treatment. As nanotechnology has a lot of theoretical significance and broad application pros pects,this paper reviews and discusses the studies on the nano drug delivery systems and its application in cancer treatment.%纳米技术(nanotechnology)是继信息、生物技术后的主导技术之一,在肿瘤的诊断及治疗领域取得了大量具有理论意义和应用价值的成果,有着广阔的应用前景.该文将对纳米载药体系及其在肿瘤治疗方面的应用等内容作简要综述.

  19. A Comparative Study of Two Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications

    Energy Technology Data Exchange (ETDEWEB)

    Mansoori, G. Ali, E-mail: mansoori@uic.edu; Brandenburg, Kenneth S. [Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St. (MC 063), Chicago, IL 60607 (United States); Shakeri-Zadeh, Ali [Department of Medical Physics, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2010-11-18

    We report a comparative study of synthesis, characteristics and in vitro tests of two folate-conjugated gold nanoparticles (AuNP) differing in linkers and AuNP sizes for selective targeting of folate-receptor positive cancerous cells. The linkers chosen were 4-aminothiophenol (4Atp) and 6-mercapto-1-hexanol (MH) with nanoconjugate products named Folate-4Atp-AuNP and Folate-MH-AuNP. We report the folate-receptor tissue distribution and its endocytosis for targeted nanotechnology. Comparison of the two nanoconjugates’ syntheses and characterization is also reported, including materials and methods of synthesis, UV-visible absorption spectroscopic measurements, Fourier Transform Infra Red (FTIR) measurements, Transmission electron microscopy (TEM) images and size distributions, X-ray diffraction data, elemental analyses and chemical stability comparison. In addition to the analytical characterization of the nanoconjugates, the cell lethality was measured in HeLa (high level of folate receptor expression) and MCF-7 (low level of folate receptor expression) cells. The nanoconjugates themselves, as well as the intense pulsed light (IPL) were not harmful to cell viability. However, upon stimulation of the folate targeted nanoconjugates with the IPL, ~98% cell killing was found in HeLa cells and only ~9% in MCF-7 cells after four hours incubation with the nanoconjugate. This demonstrates that folate targeting is effective in selecting for specific cell populations. Considering the various comparisons made, we conclude that Folate-4Atp-AuNP is superior to Folate-MH-AuNP for cancer therapy.

  20. Microfluidics & nanotechnology: Towards fully integrated analytical devices for the detection of cancer biomarkers

    KAUST Repository

    Perozziello, Gerardo

    2014-01-01

    In this paper, we describe an innovative modular microfluidic platform allowing filtering, concentration and analysis of peptides from a complex mixture. The platform is composed of a microfluidic filtering device and a superhydrophobic surface integrating surface enhanced Raman scattering (SERS) sensors. The microfluidic device was used to filter specific peptides (MW 1553.73 D) derived from the BRCA1 protein, a tumor-suppressor molecule which plays a pivotal role in the development of breast cancers, from albumin (66.5 KD), the most represented protein in human plasma. The filtering process consisted of driving the complex mixture through a porous membrane having a cut-off of 12-14 kD by hydrodynamic flow. The filtered samples coming out of the microfluidic device were subsequently deposited on a superhydrophobic surface formed by micro pillars on top of which nanograins were fabricated. The nanograins coupled to a Raman spectroscopy instrument acted as a SERS sensor and allowed analysis of the filtered sample on top of the surface once it evaporated. By using the presented platform, we demonstrate being able to sort small peptides from bigger proteins and to detect them by using a label-free technique at a resolution down to 0.1 ng μL-1. The combination of microfluidics and nanotechnology to develop the presented microfluidic platform may give rise to a new generation of biosensors capable of detecting low concentration samples from complex mixtures without the need for any sample pretreatment or labelling. The developed devices could have future applications in the field of early diagnosis of severe illnesses, e.g. early cancer detection. This journal is

  1. Therapeutic Potential of Delivering Arsenic Trioxide into HPV-Infected Cervical Cancer Cells Using Liposomal Nanotechnology.

    Science.gov (United States)

    Wang, Xiaoyan; Li, Dong; Ghali, Lucy; Xia, Ruidong; Munoz, Leonardo P; Garelick, Hemda; Bell, Celia; Wen, Xuesong

    2016-12-01

    Arsenic trioxide (ATO) has been used successfully to treat acute promyelocytic leukaemia, and since this discovery, it has also been researched as a possible treatment for other haematological and solid cancers. Even though many positive results have been found in the laboratory, wider clinical use of ATO has been compromised by its toxicity at higher concentrations. The aim of this study was to explore an improved method for delivering ATO using liposomal nanotechnology to evaluate whether this could reduce drug toxicity and improve the efficacy of ATO in treating human papillomavirus (HPV)-associated cancers. HeLa, C33a, and human keratinocytes were exposed to 5 μm of ATO in both free and liposomal forms for 48 h. The stability of the prepared samples was tested using inductively coupled plasma optical emission spectrometer (ICP-OES) to measure the intracellular arsenic concentrations after treatment. Fluorescent double-immunocytochemical staining was carried out to evaluate the protein expression levels of HPV-E6 oncogene and caspase-3. Cell apoptosis was analysed by flow cytometry. Results showed that liposomal ATO was more effective than free ATO in reducing protein levels of HPV-E6 and inducing cell apoptosis in HeLa cells. Moreover, lower toxicity was observed when liposomal-delivered ATO was used. This could be explained by lower intracellular concentrations of arsenic. The slowly accumulated intracellular ATO through liposomal delivery might act as a reservoir which releases ATO gradually to maintain its anti-HPV effects. To conclude, liposome-delivered ATO could protect cells from the direct toxic effects induced by higher concentrations of intracellular ATO. Different pathways may be involved in this process, depending on local architecture of the tissues and HPV status. PMID:26887578

  2. Therapeutic Potential of Delivering Arsenic Trioxide into HPV-Infected Cervical Cancer Cells Using Liposomal Nanotechnology

    Science.gov (United States)

    Wang, Xiaoyan; Li, Dong; Ghali, Lucy; Xia, Ruidong; Munoz, Leonardo P.; Garelick, Hemda; Bell, Celia; Wen, Xuesong

    2016-02-01

    Arsenic trioxide (ATO) has been used successfully to treat acute promyelocytic leukaemia, and since this discovery, it has also been researched as a possible treatment for other haematological and solid cancers. Even though many positive results have been found in the laboratory, wider clinical use of ATO has been compromised by its toxicity at higher concentrations. The aim of this study was to explore an improved method for delivering ATO using liposomal nanotechnology to evaluate whether this could reduce drug toxicity and improve the efficacy of ATO in treating human papillomavirus (HPV)-associated cancers. HeLa, C33a, and human keratinocytes were exposed to 5 μm of ATO in both free and liposomal forms for 48 h. The stability of the prepared samples was tested using inductively coupled plasma optical emission spectrometer (ICP-OES) to measure the intracellular arsenic concentrations after treatment. Fluorescent double-immunocytochemical staining was carried out to evaluate the protein expression levels of HPV-E6 oncogene and caspase-3. Cell apoptosis was analysed by flow cytometry. Results showed that liposomal ATO was more effective than free ATO in reducing protein levels of HPV-E6 and inducing cell apoptosis in HeLa cells. Moreover, lower toxicity was observed when liposomal-delivered ATO was used. This could be explained by lower intracellular concentrations of arsenic. The slowly accumulated intracellular ATO through liposomal delivery might act as a reservoir which releases ATO gradually to maintain its anti-HPV effects. To conclude, liposome-delivered ATO could protect cells from the direct toxic effects induced by higher concentrations of intracellular ATO. Different pathways may be involved in this process, depending on local architecture of the tissues and HPV status.

  3. A Comparative Study of Two Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications

    Directory of Open Access Journals (Sweden)

    Ali Shakeri-Zadeh

    2010-11-01

    Full Text Available We report a comparative study of synthesis, characteristics and in vitro tests of two folate-conjugated gold nanoparticles (AuNP differing in linkers and AuNP sizes for selective targeting of folate-receptor positive cancerous cells. The linkers chosen were 4-aminothiophenol (4Atp and 6-mercapto-1-hexanol (MH with nanoconjugate products named Folate-4Atp-AuNP and Folate-MH-AuNP. We report the folate-receptor tissue distribution and its endocytosis for targeted nanotechnology. Comparison of the two nanoconjugates’ syntheses and characterization is also reported, including materials and methods of synthesis, UV-visible absorption spectroscopic measurements, Fourier Transform Infra Red (FTIR measurements, Transmission electron microscopy (TEM images and size distributions, X-ray diffraction data, elemental analyses and chemical stability comparison. In addition to the analytical characterization of the nanoconjugates, the cell lethality was measured in HeLa (high level of folate receptor expression and MCF-7 (low level of folate receptor expression cells. The nanoconjugates themselves, as well as the intense pulsed light (IPL were not harmful to cell viability. However, upon stimulation of the folate targeted nanoconjugates with the IPL, ~98% cell killing was found in HeLa cells and only ~9% in MCF-7 cells after four hours incubation with the nanoconjugate. This demonstrates that folate targeting is effective in selecting for specific cell populations. Considering the various comparisons made, we conclude that Folate-4Atp-AuNP is superior to Folate-MH-AuNP for cancer therapy.

  4. Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology.

    Science.gov (United States)

    Shu, Dan; Li, Hui; Shu, Yi; Xiong, Gaofeng; Carson, William E; Haque, Farzin; Xu, Ren; Guo, Peixuan

    2015-10-27

    MicroRNAs play important roles in regulating the gene expression and life cycle of cancer cells. In particular, miR-21, an oncogenic miRNA is a major player involved in tumor initiation, progression, invasion and metastasis in several cancers, including triple negative breast cancer (TNBC). However, delivery of therapeutic miRNA or anti-miRNA specifically into cancer cells in vivo without collateral damage to healthy cells remains challenging. We report here the application of RNA nanotechnology for specific and efficient delivery of anti-miR-21 to block the growth of TNBC in orthotopic mouse models. The 15 nm therapeutic RNA nanoparticles contains the 58-nucleotide (nt) phi29 pRNA-3WJ as a core, a 8-nt sequence complementary to the seed region of miR-21, and a 39-nt epidermal growth factor receptor (EGFR) targeting aptamer for internalizing RNA nanoparticles into cancer cells via receptor mediated endocytosis. The RNase resistant and thermodynamically stable RNA nanoparticles remained intact after systemic injection into mice and strongly bound to tumors with little or no accumulation in healthy organs 8 h postinjection, and subsequently repressed tumor growth at low doses. The observed specific cancer targeting and tumor regression is a result of several key attributes of RNA nanoparticles: anionic charge which disallows nonspecific passage across negatively charged cell membrane; "active" targeting using RNA aptamers which increases the homing of RNA nanoparticles to cancer cells; nanoscale size and shape which avoids rapid renal clearance and engulfment by lung macrophages and liver Kupffer cells; favorable biodistribution profiles with little accumulation in healthy organs, which minimizes nonspecific side effects; and favorable pharmacokinetic profiles with extended in vivo half-life. The results demonstrate the clinical potentials of RNA nanotechnology based platform to deliver miRNA based therapeutics for cancer treatment.

  5. Nanotechnology Innovations

    Science.gov (United States)

    Malroy, Eric

    2010-01-01

    Nanotechnology is rapidly affecting all engineering disciplines as new products and applications are being found and brought to market. This session will present an overview of nanotechnology and let you learn about the advances in the field and how it could impact you. Some of the areas touched upon will be nanomaterials with their multifunctional capabilities, nanotechnology impact on energy systems, nanobiotechnology including nanomedicine, and nanotechnology relevant to space systems with a focus on ECLSS. Also, some important advances related to thermal systems will be presented as well as future predictions on nanotechnology.

  6. Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy

    Directory of Open Access Journals (Sweden)

    Batra Surinder K

    2011-08-01

    Full Text Available Abstract Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities against various types of aggressive and recurrent cancers. These malignancies include leukemias, lymphomas, multiple myeloma, brain cancer, melanoma and skin, lung, prostate, breast, ovarian, liver, gastrointestinal, pancreatic and colorectal epithelial cancers. Curcumin mediates its anti-proliferative, anti-invasive and apoptotic effects on cancer cells, including cancer stem/progenitor cells and their progenies, through multiple molecular mechanisms. The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2, sonic hedgehog (SHH/GLIs and Wnt/β-catenin and downstream signaling elements such as Akt, nuclear factor-kappa B (NF-κB and signal transducers and activators of transcription (STATs. In counterbalance, the high metabolic instability and poor systemic bioavailability of curcumin limit its therapeutic efficacy in human. Of great therapeutic interest, the selective delivery of synthetic analogs or nanotechnology-based formulations of curcumin to tumors, alone or in combination with other anticancer drugs, may improve their chemopreventive and chemotherapeutic efficacies against cancer progression and relapse. Novel curcumin formulations may also be used to reverse drug resistance, eradicate the total cancer cell mass and improve the anticarcinogenic efficacy of the current anti-hormonal and chemotherapeutic treatments for patients with various aggressive and lethal cancers.

  7. Nanotechnology applications in thoracic surgery.

    Science.gov (United States)

    Hofferberth, Sophie C; Grinstaff, Mark W; Colson, Yolonda L

    2016-07-01

    Nanotechnology is an emerging, rapidly evolving field with the potential to significantly impact care across the full spectrum of cancer therapy. Of note, several recent nanotechnological advances show particular promise to improve outcomes for thoracic surgical patients. A variety of nanotechnologies are described that offer possible solutions to existing challenges encountered in the detection, diagnosis and treatment of lung cancer. Nanotechnology-based imaging platforms have the ability to improve the surgical care of patients with thoracic malignancies through technological advances in intraoperative tumour localization, lymph node mapping and accuracy of tumour resection. Moreover, nanotechnology is poised to revolutionize adjuvant lung cancer therapy. Common chemotherapeutic drugs, such as paclitaxel, docetaxel and doxorubicin, are being formulated using various nanotechnologies to improve drug delivery, whereas nanoparticle (NP)-based imaging technologies can monitor the tumour microenvironment and facilitate molecularly targeted lung cancer therapy. Although early nanotechnology-based delivery systems show promise, the next frontier in lung cancer therapy is the development of 'theranostic' multifunctional NPs capable of integrating diagnosis, drug monitoring, tumour targeting and controlled drug release into various unifying platforms. This article provides an overview of key existing and emerging nanotechnology platforms that may find clinical application in thoracic surgery in the near future. PMID:26843431

  8. Astronomy and Cancer Research: X-Rays and Nanotechnology from Black Holes to Cancer Therapy

    Science.gov (United States)

    Pradhan, Anil K.; Nahar, Sultana N.

    It seems highly unlikely that any connection is to be found between astronomy and medicine. But then it also appears to be obvious: X-rays. However, that is quite superficial because the nature of X-rays in the two disciplines is quite different. Nevertheless, we describe recent research on exactly that kind of link. Furthermore, the linkage lies in atomic physics, and via spectroscopy which is a vital tool in astronomy and may also be equally valuable in biomedical research. This review begins with the physics of black hole environments as viewed through X-ray spectroscopy. It is then shown that similar physics can be applied to spectroscopic imaging and therapeutics using heavy-element (high-Z) moieties designed to target cancerous tumors. X-ray irradiation of high-Z nanomaterials as radiosensitizing agents should be extremely efficient for therapy and diagnostics (theranostics). However, broadband radiation from conventional X-ray sources (such as CT scanners) results in vast and unnecessary radiation exposure. Monochromatic X-ray sources are expected to be considerably more efficient. We have developed a new and comprehensive methodology—Resonant Nano-Plasma Theranostics (RNPT)—that encompasses the use of monochromatic X-ray sources and high-Z nanoparticles. Ongoing research entails theoretical computations, numerical simulations, and in vitro and in vivo biomedical experiments. Stemming from basic theoretical studies of Kα resonant photoabsorption and fluorescence in all elements of the Periodic Table, we have established a comprehensive multi-disciplinary program involving researchers from physics, chemistry, astronomy, pathology, radiation oncology and radiology. Large-scale calculations necessary for theory and modeling are done at a variety of computational platforms at the Ohio Supercomputer Center. The final goal is the implementation of RNPT for clinical applications.

  9. EDITORIAL: Nanotechnological selection Nanotechnological selection

    Science.gov (United States)

    Demming, Anna

    2013-01-01

    across the channel. The aim of achieving selectivity encompasses a huge range of fields in nanotechnology research, from sensing and medicine to nanoelectronics and self-assembly. As our understanding of how nanosystems behave deepens, so too does the hunger to improve our capabilities, allowing greater precision and control in manipulating these systems. Selectivity is far from trivial when shrinking to systems of nanoscale dimensions, but the range of opportunities it brings just keeps on growing. References [1] Gong X, Li J, Guo C, Xu K and Hui Y 2012 Molecular switch for tuning ions across nanopores by an external electric field Nanotechnology 24 025502 [2] Brannon-Peppas L and Blanchette J O 2004 Nanoparticle and targeted systems for cancer therapy Adv. Drug Deliv. Rev 56 1649-59 [3] Lukianova-Hleb E Y, Hanna E Y, Hafner J H and Lapotko D O 2010 Tunable plasmonic nanobubbles for cell theranostics Nanotechnology 21 085102 [4] Zhang T, Mubeen S, Myung N V and Deshusses M A 2008 Recent progress in carbon nanotube-based gas sensors Nanotechnology 19 332001 [5] Mangu R, Rajaputra S and Singh V P 2011 MWCNT-polymer composites as highly sensitive and selective room temperature gas sensors Nanotechnology 22 215502 [6]Meller A, Nivon L, Brandin E, Golovchenko J and Branton D 2000 Rapid nanopore discrimination between single polynucleotide molecules Proc. Natl Acad. Sci. 97 1079-84 [7] Asghar W, Ilyas A, Deshmukh R R, Sumitsawan S, Timmons R B and Iqbal S M 2011 Pulsed plasma polymerization for controlling shrinkage and surface composition of nanopores Nanotechnology 22 285304

  10. Nanotechnology in health care

    CERN Document Server

    Sahoo, Sanjeeb K

    2012-01-01

    Nanomedicine: Emerging Field of Nanotechnology to Human HealthNanomedicines: Impacts in Ocular Delivery and TargetingImmuno-Nanosystems to CNS Pathologies: State of the Art PEGylated Zinc Protoporphyrin: A Micelle-Forming Polymeric Drug for Cancer TherapyORMOSIL Nanoparticles: Nanomedicine Approach for Drug/Gene Delivery to the BrainMagnetic Nanoparticles: A Versatile System for Therapeutic and Imaging SystemNanobiotechnology: A New Generation of Biomedicine Application of Nanotechnology-Based Drug Delivery and Targeting to LungsAptamers and Nanomedicine in C

  11. Lipid nanotechnology.

    Science.gov (United States)

    Mashaghi, Samaneh; Jadidi, Tayebeh; Koenderink, Gijsje; Mashaghi, Alireza

    2013-01-01

    Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices and machines derived from engineering, physics, materials science, chemistry and biology. These devices have found applications in biomedical sciences, such as targeted drug delivery, bio-imaging, sensing and diagnosis of pathologies at early stages. In these applications, nano-devices typically interface with the plasma membrane of cells. On the other hand, naturally occurring nanostructures in biology have been a source of inspiration for new nanotechnological designs and hybrid nanostructures made of biological and non-biological, organic and inorganic building blocks. Lipids, with their amphiphilicity, diversity of head and tail chemistry, and antifouling properties that block nonspecific binding to lipid-coated surfaces, provide a powerful toolbox for nanotechnology. This review discusses the progress in the emerging field of lipid nanotechnology. PMID:23429269

  12. Lipid Nanotechnology

    Directory of Open Access Journals (Sweden)

    Gijsje Koenderink

    2013-02-01

    Full Text Available Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices and machines derived from engineering, physics, materials science, chemistry and biology. These devices have found applications in biomedical sciences, such as targeted drug delivery, bio-imaging, sensing and diagnosis of pathologies at early stages. In these applications, nano-devices typically interface with the plasma membrane of cells. On the other hand, naturally occurring nanostructures in biology have been a source of inspiration for new nanotechnological designs and hybrid nanostructures made of biological and non-biological, organic and inorganic building blocks. Lipids, with their amphiphilicity, diversity of head and tail chemistry, and antifouling properties that block nonspecific binding to lipid-coated surfaces, provide a powerful toolbox for nanotechnology. This review discusses the progress in the emerging field of lipid nanotechnology.

  13. Annual Report to the Nation on the Status of Cancer, 1975-2010: Questions and Answers

    Science.gov (United States)

    ... pharynx, and larynx) and increased for four others (cancer of the pancreas, liver, melanoma, and soft tissue including heart) (see ... cavity and pharynx, and gallbladder) and increased for cancers of the pancreas, liver, and uterus. 9. If cancer death rates ...

  14. What Is the Role of Nanotechnology in Diagnosis and Treatment of Metastatic Breast Cancer? Promising Scenarios for the Near Future

    Directory of Open Access Journals (Sweden)

    Truffi Marta

    2016-01-01

    Full Text Available Metastatic breast cancer represents a diagnostic and therapeutic challenge due to tumor heterogeneity and to various physiological barriers that hinder drug delivery to the metastatic sites. To overcome these limitations, nanoformulated drugs have been developed and tested in preclinical studies, and few of them have been successfully translated into clinical practice. In particular, liposomal anthracyclines and nanoformulated albumin-bound paclitaxel have revealed an improved therapeutic index when compared to conventional chemotherapy, with significant reduction of drugs toxicity. Several strategies for nanoparticles engineering have more recently been explored to increase selectivity for tumor cells and to reach poorly accessible metastatic districts. Targeted nanoparticles, directed toward tumor markers and tissue-specific metastases, may provide effective devices in case of low-vascularized and small-sized metastases, thus paving the way for a real change in the natural history of metastatic disease. A number of targets have been identified and exploited for surface functionalization of different types of nanoparticles, which are currently undergoing preclinical studies. The aim of this review is to provide an overview of current nanotechnology applied to metastatic breast cancer diagnosis and treatment. Promising results encourage an upcoming translation of this research into clinical practice for an effective management of the disease in the near future.

  15. Toward automated classification of consumers' cancer-related questions with a new taxonomy of expected answer types.

    Science.gov (United States)

    McRoy, Susan; Jones, Sean; Kurmally, Adam

    2016-09-01

    This article examines methods for automated question classification applied to cancer-related questions that people have asked on the web. This work is part of a broader effort to provide automated question answering for health education. We created a new corpus of consumer-health questions related to cancer and a new taxonomy for those questions. We then compared the effectiveness of different statistical methods for developing classifiers, including weighted classification and resampling. Basic methods for building classifiers were limited by the high variability in the natural distribution of questions and typical refinement approaches of feature selection and merging categories achieved only small improvements to classifier accuracy. Best performance was achieved using weighted classification and resampling methods, the latter yielding an accuracy of F1 = 0.963. Thus, it would appear that statistical classifiers can be trained on natural data, but only if natural distributions of classes are smoothed. Such classifiers would be useful for automated question answering, for enriching web-based content, or assisting clinical professionals to answer questions. PMID:25759063

  16. Toward automated classification of consumers' cancer-related questions with a new taxonomy of expected answer types.

    Science.gov (United States)

    McRoy, Susan; Jones, Sean; Kurmally, Adam

    2016-09-01

    This article examines methods for automated question classification applied to cancer-related questions that people have asked on the web. This work is part of a broader effort to provide automated question answering for health education. We created a new corpus of consumer-health questions related to cancer and a new taxonomy for those questions. We then compared the effectiveness of different statistical methods for developing classifiers, including weighted classification and resampling. Basic methods for building classifiers were limited by the high variability in the natural distribution of questions and typical refinement approaches of feature selection and merging categories achieved only small improvements to classifier accuracy. Best performance was achieved using weighted classification and resampling methods, the latter yielding an accuracy of F1 = 0.963. Thus, it would appear that statistical classifiers can be trained on natural data, but only if natural distributions of classes are smoothed. Such classifiers would be useful for automated question answering, for enriching web-based content, or assisting clinical professionals to answer questions.

  17. Lipid Nanotechnology

    NARCIS (Netherlands)

    Mashaghi, Samaneh; Jadidi, Tayebeh; Koenderink, Gijsje; Mashaghi, Alireza

    2013-01-01

    Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices and machines derived from engineering, physics, materials science, chemistry and biology. These devices have found applications in biomedical sciences, such as targeted drug delivery, bio-imaging, sensing and

  18. Recent insights into nanotechnology development for detection and treatment of colorectal cancer

    OpenAIRE

    Viswanath B; Kim S.; Lee K

    2016-01-01

    Buddolla Viswanath,1 Sanghyo Kim,1 Kiyoung Lee2 1Department of Bionanotechnology, Gachon University, Gyeonggi-Do, 2Division of Endocrinology and Metabolism, Gachon University Gil Hospital, Incheon, Republic of Korea Abstract: The global incidence of colorectal cancer (CRC) is 1.3 million cases. It is the third most frequent cancer in males and females. Most CRCs are adenocarcinomas and often begin as a polyp on the inner wall of the rectum or colon. Some of these polyps become malignant, ev...

  19. Nanotechnology in respiratory medicine.

    Science.gov (United States)

    Omlor, Albert Joachim; Nguyen, Juliane; Bals, Robert; Dinh, Quoc Thai

    2015-01-01

    Like two sides of the same coin, nanotechnology can be both boon and bane for respiratory medicine. Nanomaterials open new ways in diagnostics and treatment of lung diseases. Nanoparticle based drug delivery systems can help against diseases such as lung cancer, tuberculosis, and pulmonary fibrosis. Moreover, nanoparticles can be loaded with DNA and act as vectors for gene therapy in diseases like cystic fibrosis. Even lung diagnostics with computer tomography (CT) or magnetic resonance imaging (MRI) profits from new nanoparticle based contrast agents. However, the risks of nanotechnology also have to be taken into consideration as engineered nanomaterials resemble natural fine dusts and fibers, which are known to be harmful for the respiratory system in many cases. Recent studies have shown that nanoparticles in the respiratory tract can influence the immune system, can create oxidative stress and even cause genotoxicity. Another important aspect to assess the safety of nanotechnology based products is the absorption of nanoparticles. It was demonstrated that the amount of pulmonary nanoparticle uptake not only depends on physical and chemical nanoparticle characteristics but also on the health status of the organism. The huge diversity in nanotechnology could revolutionize medicine but makes safety assessment a challenging task. PMID:26021823

  20. Nanotechnology in respiratory medicine.

    Science.gov (United States)

    Omlor, Albert Joachim; Nguyen, Juliane; Bals, Robert; Dinh, Quoc Thai

    2015-05-29

    Like two sides of the same coin, nanotechnology can be both boon and bane for respiratory medicine. Nanomaterials open new ways in diagnostics and treatment of lung diseases. Nanoparticle based drug delivery systems can help against diseases such as lung cancer, tuberculosis, and pulmonary fibrosis. Moreover, nanoparticles can be loaded with DNA and act as vectors for gene therapy in diseases like cystic fibrosis. Even lung diagnostics with computer tomography (CT) or magnetic resonance imaging (MRI) profits from new nanoparticle based contrast agents. However, the risks of nanotechnology also have to be taken into consideration as engineered nanomaterials resemble natural fine dusts and fibers, which are known to be harmful for the respiratory system in many cases. Recent studies have shown that nanoparticles in the respiratory tract can influence the immune system, can create oxidative stress and even cause genotoxicity. Another important aspect to assess the safety of nanotechnology based products is the absorption of nanoparticles. It was demonstrated that the amount of pulmonary nanoparticle uptake not only depends on physical and chemical nanoparticle characteristics but also on the health status of the organism. The huge diversity in nanotechnology could revolutionize medicine but makes safety assessment a challenging task.

  1. Review on early technology assessments of nanotechnologies in oncology

    NARCIS (Netherlands)

    Retèl, Valesca P.; Hummel, Marjan J.M.; Harten, van Wim

    2009-01-01

    Nanotechnology is expected to play an increasingly important role in the diagnostics, prognostics, and management of targeted cancer treatments. While papers have described promising results for nanotechnology in experimental settings, the translation of fundamental research into clinical applicatio

  2. Nanotechnology and cancer: improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles

    OpenAIRE

    Sweeney, Sean K; Luo, Yi; Michael A. O’Donnell; Assouline, Jose

    2016-01-01

    Background Despite being one of the most common cancers, bladder cancer is largely inefficiently and inaccurately staged and monitored. Current imaging methods detect cancer only when it has reached “visible” size and has significantly disrupted the structure of the organ. By that time, thousands of cells will have proliferated and perhaps metastasized. Repeated biopsies and scans are necessary to determine the effect of therapy on cancer growth. In this report, we describe a novel approach b...

  3. Complement-mediated tumour growth: implications for cancer nanotechnology and nanomedicines

    DEFF Research Database (Denmark)

    Moghimi, S. M.; Andresen, Thomas Lars

    2009-01-01

    The recent unexpected observation that complement activation helps turnout growth and progression has an important bearing on the future development of cancer nanomedicines for site-specific tumour targeting as these entities are capable of triggering complement. These issues are discussed and su...

  4. The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer

    Directory of Open Access Journals (Sweden)

    Andras G. Lacko

    2013-06-01

    Full Text Available Triple Negative Breast Cancer, TNBC, a highly aggressive and metastatic type of breast cancer, is characterized by loss of expression of the estrogen receptor (ER, progesterone receptor (PR, and a lack of overexpression of the human epidermal growth factor receptor 2 (HER2. It is a heterogeneous group of tumors with diverse histology, molecular uniqueness and response to treatment. Unfortunately, TNBC patients do not benefit from current anti-HER2 or hormone positive targeted breast cancer treatments; consequently, these patients rely primarily on chemotherapy. However, the 5-year survival rate for woman with metastatic TNBC is less than 30%. As a result of ineffective treatments, TNBC tumors often progress to metastatic lesions in the brain and lung. Brain metastases of invasive breast cancer are associated with 1 and 2 year survival rate of 20% and <2% respectively. Because the only current systemic treatment for TNBC is chemotherapy, alternative targeted therapies are urgently needed to improve the prognosis for TNBC patients. This review is focused on opportunities for developing new approaches for filling the current void in an effective treatment for TNBC patients.

  5. Lipid Nanotechnology

    OpenAIRE

    Gijsje Koenderink; Samaneh Mashaghi; Tayebeh Jadidi; Alireza Mashaghi

    2013-01-01

    Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices and machines derived from engineering, physics, materials science, chemistry and biology. These devices have found applications in biomedical sciences, such as targeted drug delivery, bio-imaging, sensing and diagnosis of pathologies at early stages. In these applications, nano-devices typically interface with the plasma membrane of cells. On the other hand, naturally occurring nanostructures in biolog...

  6. Evaluation of a nanotechnology based carrier for delivery of curcumin in prostate cancer cells

    OpenAIRE

    Thangapazham, Rajesh L.; Puri, Anu; Tele, Shrikant; Blumenthal, Robert; Maheshwari, Radha K.

    2008-01-01

    We have initiated studies to enhance targeted delivery of an anticancer agent, curcumin, for prostate cancer treatment by incorporating this agent into the liposomes (nanodelivery vehicles primarily composed of phospholipids) coated with prostate membrane specific antigen specific antibodies. We prepared curcumin-loaded liposomes of various lipid compositions by sonication at an average size of 100–150 nm. Un-entrapped curcumin was removed by size exclusion chromatography. Data show that curc...

  7. Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

    OpenAIRE

    Giovana Maria Fioramonti Calixto; Jéssica Bernegossi; Laura Marise de Freitas; Carla Raquel Fontana; Marlus Chorilli

    2016-01-01

    Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug deliver...

  8. Cancer in pregnancy: Motherisk on-line question and answer forum

    OpenAIRE

    Grupp, Sandy; Einarson, Adrienne; Koren, Gideon

    2007-01-01

    QUESTION It seems to me that cancer is occurring or being diagnosed more frequently among young women who are or might become pregnant. In the past year, I have seen several such women in my practice and I have had difficulty finding appropriate information in order to counsel them. Is there somewhere I can go for information about cancer during pregnancy so that I can better educate and inform these patients?

  9. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells.

    Science.gov (United States)

    Thangapazham, Rajesh L; Puri, Anu; Tele, Shrikant; Blumenthal, Robert; Maheshwari, Radha K

    2008-05-01

    We have initiated studies to enhance targeted delivery of an anticancer agent, curcumin, for prostate cancer treatment by incorporating this agent into the liposomes (nanodelivery vehicles primarily composed of phospholipids) coated with prostate membrane specific antigen specific antibodies. We prepared curcumin-loaded liposomes of various lipid compositions by sonication at an average size of 100-150 nm. Un-entrapped curcumin was removed by size exclusion chromatography. Data show that curcumin preferentially partitioned into liposomes prepared from dimyristoyl phosphatidyl choline (DMPC) and cholesterol among the various compositions tested. The anti-proliferative activity of liposomal curcumin was studied using two human prostate cancer cell lines (LNCaP and C4-2B) by a tetrazolium dye-based (MTT) assay. Treatment of cells with liposomal curcumin (5-10 microM) for 24-48 h at 37 degrees C resulted in at least 70-80% inhibition of cellular proliferation without affecting their viability. On the other hand, free curcumin exhibited similar inhibition only at 10-fold higher doses (>50 microM). We also observed that LNCaP cells were relatively more sensitive to liposomal curcumin mediated block of cellular proliferation than C4-2B cells. We are currently developing liposome formulations with targeting ability to further improve the efficacy of curcumin in vivo.

  10. Diverticular Disease and Colorectal Cancer: Incidental Diagnosis or Real Association? Final Answer.

    Science.gov (United States)

    Regula, Jaroslaw

    2016-10-01

    Associations between diverticular disease of the colon and the colorectal cancer has been studied for >60 years. Observational, cross-sectional, and case-control studies as well as large population-based studies gave conflicting results and association was not fully proven. Obtaining the proof was difficult because both diseases share similar clinical characteristics, both increase with age, and both involve similar dietary factors. Long-term observations are difficult as diagnostic methods changed over time from barium enema 50 to 60 years ago, through endoscopy, up to CT and MR in recent years. Cancer or adenomas may be missed within diverticular segment; diverticula may be underreported in patients with colon cancer diagnosis. Most recent 2 large cohort studies have solved the dilemma. These studies have clearly shown that diverticular disease does not increase the risk of colon cancer after the first year of diagnosis. Within the first year of diagnosis the association is strong, most probably due to difficulties with differential diagnosis and misclassifications and shared symptoms. Findings of these studies have led to the conclusion that colon cancer has to be excluded using modern techniques after the first episode of suspected diverticulitis. PMID:27622360

  11. Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology

    Institute of Scientific and Technical Information of China (English)

    Xue Xue; Xing-Jie Liang

    2012-01-01

    Multidrug resistance (MDR),which significantly decreases the efficacy of anticancer drugs and causes tumor recurrence,has been a major challenge in clinical cancer treatment with chemotherapeutic drugs for decades.Several mechanisms of overcoming drug resistance have been postulated.Well known Pglycoprotein (P-gp) and other drug efflux transporters are considered to be critical in pumping anticancer drugs out of cells and causing chemotherapy failure.Innovative theranostic (therapeutic and diagnostic)strategies with nanoparticles are rapidly evolving and are anticipated to offer opportunities to overcome these limits.In this review,we discuss the mechanisms of drug efflux-mediated resistance and the application of multiple nanoparticle-based platforms to overcome chemoresistance and improve therapeutic outcome.

  12. EDITORIAL: Terahertz nanotechnology Terahertz nanotechnology

    Science.gov (United States)

    Demming, Anna; Tonouchi, Masayoshi; Reno, John L.

    2013-05-01

    A useful synergy is being established between terahertz research and nanotechnology. High power sources [1-3] and detectors [4] in what was once considered the terahertz 'frequency gap' [5] in the electromagnetic spectrum have stimulated research with huge potential benefits in a range of industries including food, medicine and security, as well as fundamental physics and astrophysics. This special section, with guest editors Masayoshi Tonouchi and John Reno, gives a glimpse of the new horizons nanotechnology is broaching in terahertz research. While the wavelengths relevant to the terahertz domain range from hundreds of micrometres to millimetres, structures at the nanoscale reveal interesting low energy dynamics in this region. As a result terahertz spectroscopy techniques are becoming increasingly important in nanomaterial characterization, as demonstrated in this special section by colleagues at the University of Oxford in the UK and the Australian National University. They use terahertz spectroscopy to identify the best nanostructure parameters for specific applications [6]. The low energy dynamics in nanostructures also makes them valuable tools for terahertz detection [7]. In addition the much sought after terahertz detection over broadband frequency ranges has been demonstrated, providing versatility that has been greatly in demand, particularly in spectroscopy applications [8, 9]. Also in this special section, researchers in Germany and China tackle some of the coupling issues in terahertz time domain spectroscopy with an emitter specifically well suited for systems operated with an amplified fibre [3]. 'In medical imaging, the advantage of THz radiation is safety, because its energy is much lower than the ionization energy of biological molecules, in contrast to hazardous x-ray radiation,' explains Joo-Hiuk Son from the University of Seoul in Korea in his review [10]. As he also points out, the rotational and vibrational energies of water molecules are

  13. Nanotechnology-based approaches in anticancer research.

    Science.gov (United States)

    Jabir, Nasimudeen R; Tabrez, Shams; Ashraf, Ghulam Md; Shakil, Shazi; Damanhouri, Ghazi A; Kamal, Mohammad A

    2012-01-01

    Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor margins, identify residual tumor cells and micrometastases, and determine whether a tumor has been completely removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resistance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. The present review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

  14. Early phase Technology Assessment of nanotechnology in oncology

    NARCIS (Netherlands)

    Retèl, Valesca P.; Hummel, Marjan J.M.; Harten, van Willem H.

    2008-01-01

    To perform early Technology Assessment (TA) of nanotechnology in oncology. The possibilities of nanotechnology for detection (imaging), diagnosis and treatment of cancer are subject of different research programs where major investments are concerned. As a range of bio- nanotechnologies is expected

  15. EDITORIAL: Multitasking in nanotechnology Multitasking in nanotechnology

    Science.gov (United States)

    Demming, Anna

    2013-06-01

    of myocardial infarct: MR antibody imaging Radiology 182 381-5 [4] Kirui D K, Rey D A and Batt C A 2010 Gold hybrid nanoparticles for targeted phototherapy and cancer imaging Nanotechnology 21 105105 [5] Villanueva A, Cãete M, Roca A G, Calero M, Veintemillas-Verdaguer S, Serna C J, Del Puerto Morales M and Miranda R 2009 The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells Nanotechnology 20 115103 [6]Theil Hansen L, Kühle A, Sørensen A H, Bohr J and Lindelof P E 1998 A technique for positioning nanoparticles using an atomic force microscope Nanotechnology 9 337-42 [7] Lu X, Yu M, Huang H and Ruoff R S 1999 Tailoring graphite with the goal of achieving single sheets Nanotechnology 10 269-72 [8] Baur C et al 1998 Nanoparticle manipulation by mechanical pushing: underlying phenomena and real-time monitoring Nanotechnology 9 360-4 [9] Ando T 2012 High-speed atomic force microscopy coming of age Nanotechnology 23 062001 [10] Romano G, Mantini G, Carlo A D, D'Amico A, Falconi C and Wang Z L 2011 Piezoelectric potential in vertically aligned nanowires for high output nanogenerators Nanotechnology 22 465401 [11] Yu A, Zhao Y, Jiang P and Wang Z L 2013 A nanogenerator as a self-powered sensor for measuring the vibration spectrum of a drum membrane Nanotechnology 24 055501 [12] When Art Meets Science: Exhibition of Artwork by Frédérique Swist http://www.at-bristol.org.uk/159.html

  16. Computers, Nanotechnology and Mind

    Science.gov (United States)

    Ekdahl, Bertil

    2008-10-01

    In 1958, two years after the Dartmouth conference, where the term artificial intelligence was coined, Herbert Simon and Allen Newell asserted the existence of "machines that think, that learn and create." They were further prophesying that the machines' capacity would increase and be on par with the human mind. Now, 50 years later, computers perform many more tasks than one could imagine in the 1950s but, virtually, no computer can do more than could the first digital computer, developed by John von Neumann in the 1940s. Computers still follow algorithms, they do not create them. However, the development of nanotechnology seems to have given rise to new hopes. With nanotechnology two things are supposed to happen. Firstly, due to the small scale it will be possible to construct huge computer memories which are supposed to be the precondition for building an artificial brain, secondly, nanotechnology will make it possible to scan the brain which in turn will make reverse engineering possible; the mind will be decoded by studying the brain. The consequence of such a belief is that the brain is no more than a calculator, i.e., all that the mind can do is in principle the results of arithmetical operations. Computers are equivalent to formal systems which in turn was an answer to an idea by Hilbert that proofs should contain ideal statements for which operations cannot be applied in a contentual way. The advocates of artificial intelligence will place content in a machine that is developed not only to be free of content but also cannot contain content. In this paper I argue that the hope for artificial intelligence is in vain.

  17. Patent Landscape for Nanotechnology

    OpenAIRE

    Alexey Streletskiy; Vladimir Zabavnikov; Emil Aslanov; Dmitriy Kotlov

    2015-01-01

    A methodological approach to patent landscaping for nanotechnology is considered in this paper. In the opinion of the authors, nanotechnologies have precedence over other technology trends that are confirmed by evaluation of the present and future market size of nanotechnology productions. An analysis of patent activity in Russia and the world is performed using patent landscape for nanotechnology as well as for metallurgy in the field of nanotechnology. A new metho...

  18. EDITORIAL: Terahertz nanotechnology Terahertz nanotechnology

    Science.gov (United States)

    Demming, Anna; Tonouchi, Masayoshi; Reno, John L.

    2013-05-01

    A useful synergy is being established between terahertz research and nanotechnology. High power sources [1-3] and detectors [4] in what was once considered the terahertz 'frequency gap' [5] in the electromagnetic spectrum have stimulated research with huge potential benefits in a range of industries including food, medicine and security, as well as fundamental physics and astrophysics. This special section, with guest editors Masayoshi Tonouchi and John Reno, gives a glimpse of the new horizons nanotechnology is broaching in terahertz research. While the wavelengths relevant to the terahertz domain range from hundreds of micrometres to millimetres, structures at the nanoscale reveal interesting low energy dynamics in this region. As a result terahertz spectroscopy techniques are becoming increasingly important in nanomaterial characterization, as demonstrated in this special section by colleagues at the University of Oxford in the UK and the Australian National University. They use terahertz spectroscopy to identify the best nanostructure parameters for specific applications [6]. The low energy dynamics in nanostructures also makes them valuable tools for terahertz detection [7]. In addition the much sought after terahertz detection over broadband frequency ranges has been demonstrated, providing versatility that has been greatly in demand, particularly in spectroscopy applications [8, 9]. Also in this special section, researchers in Germany and China tackle some of the coupling issues in terahertz time domain spectroscopy with an emitter specifically well suited for systems operated with an amplified fibre [3]. 'In medical imaging, the advantage of THz radiation is safety, because its energy is much lower than the ionization energy of biological molecules, in contrast to hazardous x-ray radiation,' explains Joo-Hiuk Son from the University of Seoul in Korea in his review [10]. As he also points out, the rotational and vibrational energies of water molecules are

  19. Is the increasing cost of technology an answer to winning the war on cancer?

    International Nuclear Information System (INIS)

    Full text: Over the last decades, progress in radiation physics and technology has enormously increased the precision with which radiotherapy can be delivered. This allows conformity of the high dose volume around the (assumed) tumour volume, with complex shapes, thus providing a basis e.g. for dose escalation, hypofractionation and stereotactic treatment. However, further improvements in con formality by technological advances will only be minor. Therefore, additional strategies-biology based-must be considered in order to either increase the sensitivity of the tumours or the resistance of critical normal tissues. Tumour 'targeting' can aim at biological characteristics specific for tumours, such as hypoxia/micromilieu or particular signalling pathways. Inhibition of the receptor for the epidermal growth factor is one advanced example. Moreover, combining external beam irradiation with internal irradiation via receptor-linked radionuclides may be applied to increase tumour doses. Normal tissues always have to be included in the high dose volume of radiation therapy: Within the tumour, at the tumour margins where microscopic spread must be assumed, and also in the margins that have to be added due to physiological and treatment-induced movements of the target. Recently, a number of approaches to selectively modify side effects of radiotherapy by interventions in normal tissue radio-pathobiology have been successfully investigated in preclinical models and in first clinical studies. All these targeting approaches must be tested for their efficacy and also their selectivity in preclinical (animal) models, with relevant irradiation protocols and suitable endpoints. In conclusion, investments in radiation oncology should also focus on the promotion of these tumour and/or normal tissue targeting strategies, in order to more effectively fight cancer, in combination with optimal (physical) administration of radiotherapy.

  20. Application of Nanotechnology in Therapy of Prostate Cancer%纳米技术在前列腺癌诊疗中的应用

    Institute of Scientific and Technical Information of China (English)

    黄星华; 谭国斌; 李冠奕; 吴上超; 周建华

    2016-01-01

    The application of nanotechnology in medicine is offering many exciting possibilities in healthcare, partic-ularly by targeted delivery of anticancer drugs and imaging contrast agents. Prostate cancer is the cause of the most com-mon malignant tumours and is the second leading cause of cancer death among American and European men. The inci-dence of prostate cancer increases in our country,because of the change of diet structure and life style.The nanoparticles could overcome the lack of specificity of conventional chemotherapeutic agents and the low of sensitivity of the early detection of precancerous. In this paper, the Application of nanotechnology in therapy of prostate cancer will be reviewed.%纳米技术在医学上的应用具有较好的发展前景,特别是在抗肿瘤药物的靶向给药和影像增强剂方面。前列腺癌是欧美男性最常见的恶性肿瘤,位于男性肿瘤死亡率的第二位。随着人口寿命延长、饮食结构和生活方式改变,我国前列腺癌发病率不断升高。纳米技术的发展有利于克服传统化疗药物特异性低和癌前病变早期检测低灵敏度等难题。本文主要对纳米技术在前列腺癌治疗中的应用进行综述。

  1. Green nanotechnology

    Science.gov (United States)

    Smith, Geoff B.

    2011-10-01

    Nanotechnology, in particular nanophotonics, is proving essential to achieving green outcomes of sustainability and renewable energy at the scales needed. Coatings, composites and polymeric structures used in windows, roof and wall coatings, energy storage, insulation and other components in energy efficient buildings will increasingly involve nanostructure, as will solar cells. Nanostructures have the potential to revolutionize thermoelectric power and may one day provide efficient refrigerant free cooling. Nanomaterials enable optimization of optical, opto-electrical and thermal responses to this urgent task. Optical harmonization of material responses to environmental energy flows involves (i) large changes in spectral response over limited wavelength bands (ii) tailoring to environmental dynamics. The latter includes engineering angle of incidence dependencies and switchable (or chromogenic) responses. Nanomaterials can be made at sufficient scale and low enough cost to be both economic and to have a high impact on a short time scale. Issues to be addressed include human safety and property changes induced during manufacture, handling and outdoor use. Unexpected bonuses have arisen in this work, for example the savings and environmental benefits of cool roofs extend beyond the more obvious benefit of reduced heat flows from the roof into the building.

  2. 纳米技术在肿瘤诊断与治疗中的应用%Application of nanotechnology in cancer diagnosis and therapy

    Institute of Scientific and Technical Information of China (English)

    袁玫; 陈继营; 卢世璧

    2009-01-01

    纳米技术最近的发展为医学领域提供了新的有效手段,形成了纳米医学的新领域.在肿瘤的诊断与治疗方面,由于纳米颗粒的体积是肿瘤细胞的1/100~1/1000,它可从肿瘤区血管漏出,并通过与肿瘤细胞的靶位连接,进入肿瘤细胞的表面或胞质及核内,从而成为肿瘤细胞的特异载体而被应用于肿瘤的诊断和治疗.%Recent developments in nanotechnology have provided researchers with new tools for cancer diagnosis and therapy.Since these nanoparticals are 100-1000-fold smaller than cancer cells,they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells.Therefore,their application as cancer cell-specific delivery vehicles will be a significant addition to currently available armory for cancer diagnosis and therapy.

  3. Is cancer a disease that can be cured? An answer based on a new classification of diseases

    CERN Document Server

    Richmond, Peter

    2016-01-01

    Is cancer a disease that can be cured or a degenerative disease which comes predominantly with old age? We give an answer based on a two-dimensional representation of diseases. These two dimensions are defined as follows. In mortality curves there is an age, namely a_c = 10 years, which plays a crucial role in the sense that the mortality rate decreases in the interval I1=(aa_c). The respective trends in I1 and I2 are the two parameters used in our classification of diseases. Within the framework of reliability analysis, I1 and I2 would be referred to as the "burn-in" and "wear-out" phases. This leads to define three broad groups of diseases. (AS1) Asymmetry with prevalence of I1. (AS2) Asymmetry with prevalence of I2. (S) Symmetry, with I1 and I2 both playing roles of comparable importance. Not surprisingly, among AS1-cases one finds all diseases due to congenital malformations. In the AS2-class one finds degenerative diseases, e.g. Alzheimer's disease. Among S-cases one finds most diseases due to external p...

  4. Can nanotechnology potentiate photodynamic therapy?

    OpenAIRE

    Huang, Ying-Ying; Sharma, Sulbha K.; Dai, Tianhong; Chung, Hoon; Yaroslavsky, Anastasia; Garcia-Diaz, Maria; Chang, Julie; Long Y. Chiang; Hamblin, Michael R.

    2012-01-01

    Photodynamic therapy (PDT) uses the combination of non-toxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposom...

  5. Nanotechnology for armor: hype, facts, and future

    Science.gov (United States)

    Maher, Mick

    2012-06-01

    Over the past two decades, nanotechnology has offered the promise of revolutionary performance improvements over existing armor materials. During that time there was substantial effort and resources put into developing the material technology and supporting theories, with only limited emphasis placed on understanding the ballistic event, mechanisms that drive armor performance, and the dependent nature of the threat. As a result, this large investment in nanotechnology for armor has not produced improved performance on the ballistics testing range, and armor nanotechnologies have never been fielded. No matter what the platform, armor systems have several functions that they have to perform in order to function properly. In order to defeat a threat, armor systems are designed to: deform/deflect the threat; dissipate energy; and prevent residual debris penetration. To date there is no definitive answer as to what material properties drive the system behavior of these functions at high rates in response to a specific threat, making the adaptation of nanotechnology that much harder. However, these functions are now being considered with respect to the material system and armor mechanism being utilized, and nanotechnology is beginning to be shown as an effective means of improving performance. When looking at the materials being used today, there are examples of nanotechnology making inroads into today's latest systems. Nano-particles are being used to manipulate grain boundaries in both metals and ceramics to tailor performance. Composite materials are utilizing nanotechnology to enhance basic material properties and enhance the system level behaviors to high rate events. While the anticipated revolution never occurred, nanotechnology is beginning to be utilized as an enabler in the latest armor performance improvements.

  6. 纳米技术在乳腺癌治疗研究中的进展%Progress of nanotechnology on the treatment of breast cancer

    Institute of Scientific and Technical Information of China (English)

    李想; 周晓倩; 金慧; 郑淼; 刘俊

    2015-01-01

    近年来,纳米技术作为一项新的技术开拓了医学的新领域,为治疗很多疾病提供了新的方法。在乳腺癌治疗的研究中,发现纳米载体能很好地携带乳腺癌常用化疗药物,并能稳定释放药物。纳米材料在乳腺癌治疗方面有很好的靶向作用。在被动靶向方面,纳米载体能利用肿瘤微环境的改变提高增强渗透滞留效应,增加肿瘤局部药物浓度,进而提高抗乳腺癌效果;在主动靶向方面,乳腺癌分子靶向及磁性纳米微粒介导的靶向可提高乳腺癌细胞对抗癌药物的摄入。此外,纳米载体利用靶向效应部分逆转乳腺癌多药耐药,利用沉默相关耐药基因达到加强逆转的效果的作用。对于乳腺癌转移方面,纳米药物载体可以降低乳腺癌转移的风险,提高治疗乳腺癌骨转移的效果,对乳腺癌相关骨质疏松有一定的治疗效果。纳米技术在乳腺癌治疗中的应用前景越来越广阔。%In recent years, nanotechnology as a new technology expands the field of medicine, and provides a new method for the treatment of many diseases. For breast cancer, some studies found that nanoparticles used as carriers could well carry conventional chemotherapy drugs and release drugs stably. Targeted therapy is an important application of nanomaterials in the treatment of breast cancer, including active and passive targeting. On passive targeting, nanoparticles can improve the enhanced permeability and retention effect and increase local drug concentration in tumor cells by changing the tumor microenvironments, so as to improve the effect of anti-breast cancer therapy. On active targeting, molecular targeting and magnetic nanoparticles mediated targeting can increase the uptake of anticancer drugs in breast cancer cells. In addition, nanoparticles can reverse the multi-drug resistance of breast cancer based on targeting effect and silencing related resistant genes. For the

  7. Nanotechnology in dentistry: prevention, diagnosis, and therapy

    Science.gov (United States)

    Abou Neel, Ensanya Ali; Bozec, Laurent; Perez, Roman A; Kim, Hae-Won; Knowles, Jonathan C

    2015-01-01

    Nanotechnology has rapidly expanded into all areas of science; it offers significant alternative ways to solve scientific and medical questions and problems. In dentistry, nanotechnology has been exploited in the development of restorative materials with some significant success. This review discusses nanointerfaces that could compromise the longevity of dental restorations, and how nanotechnolgy has been employed to modify them for providing long-term successful restorations. It also focuses on some challenging areas in dentistry, eg, oral biofilm and cancers, and how nanotechnology overcomes these challenges. The recent advances in nanodentistry and innovations in oral health-related diagnostic, preventive, and therapeutic methods required to maintain and obtain perfect oral health, have been discussed. The recent advances in nanotechnology could hold promise in bringing a paradigm shift in dental field. Although there are numerous complex therapies being developed to treat many diseases, their clinical use requires careful consideration of the expense of synthesis and implementation. PMID:26504385

  8. Expansions of Nanotechnology

    OpenAIRE

    van Lente, Harro; Coenen, Christopher; Fleischer, Torsten [Hrsg.; Konrad, Kornelia; Krabbenborg, Lotte; Milburn, Colin; Thoreau, François; Zülsdorf, Torben

    2012-01-01

    Little by little, nanotechnology has emerged amid enormous anticipations and fantastic promises of new materials, aspiring to manipulate our world “atom by atom.” While these grand visions continue to capture the imaginations of various audiences—and continue to be contested, as well—nanotechnology has developed into more than that. During the last two decades, many research programs and industrial R&D expenditures have resulted in actual products and tangible innovations. Nanotechnology, it ...

  9. Nanotechnology, No Free Lunch

    OpenAIRE

    Paull, John

    2010-01-01

    Nanotechnology is the new science and technology of the super small. Particles at the nano-scale, from one to one hundred billionths of a metre, exhibit novel properties. Nanotechnology is an active area of research and rapid commercialization. The food industry has been targeted as a potential recipient of this new technology and engineered nanoparticles are reportedly already in some super-market products. Nanotechnology is currently unregulated, and there are no requirements for mandatory ...

  10. Nanotechnology: thinking small.

    OpenAIRE

    May, M.

    1999-01-01

    Nanotechnology--building devices on the atomic scale--may unleash some big scientific advances early in the new millennium. Last January in Arlington, Virginia, nearly 100 representatives from academia, industry, and government laid out the general goals for the next decade of nanotechnology research by U.S. government agencies. Some predict that the potentially rich opportunities in this field may trigger a nanotechnology initiative in the federal budget request for Fiscal Year 2001. In the ...

  11. Is basic research providing answers if adjuvant anti-estrogen treatment of breast cancer can induce cognitive impairment?

    NARCIS (Netherlands)

    Buwalda, Bauke; Schagen, Sanne B.

    2013-01-01

    Adjuvant treatment of cancer by chemotherapy is associated with cognitive impairment in some cancer survivors. Breast cancer patients are frequently also receiving endocrine therapy with selective estrogen receptor modulators (SERMs) and/or aromatase inhibitors (AIs) to suppress the growth of estrad

  12. Vectors for Inhaled Gene Therapy in Lung Cancer. Application for Nano Oncology and Safety of Bio Nanotechnology

    Directory of Open Access Journals (Sweden)

    Konstantinos Zarogoulidis

    2012-08-01

    Full Text Available Novel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.

  13. Vectors for Inhaled Gene Therapy in Lung Cancer. Application for Nano Oncology and Safety of Bio Nanotechnology

    OpenAIRE

    Konstantinos Zarogoulidis; Goldberg, Eugene P.; Wolfgang Hohenforst-Schimdt; Haidong Huang; Kalliopi Domvri; Konstantinos Porpodis; Karamanos, Nikos K.; Paul Zarogouldis

    2012-01-01

    Novel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano...

  14. 78 FR 60319 - Request for Information: NNI Nanotechnology for Sensors and Sensors for Nanotechnology Signature...

    Science.gov (United States)

    2013-10-01

    ... TECHNOLOGY POLICY NATIONAL NANOTECHNOLOGY COORDINATION OFFICE Request for Information: NNI Nanotechnology for Sensors and Sensors for Nanotechnology Signature Initiative ACTION: Notice of request for information... Nanotechnology Initiative (NNI) and of the Nanotechnology Signature Initiative (NSI) entitled Nanotechnology...

  15. Nanotechnology and Social Context

    Science.gov (United States)

    Sandler, Ronald

    2007-01-01

    The central claims defended in this article are the following: (a) The social and ethical challenges of nanotechnology can be fully identified only if both the characteristic features of nanotechnologies and the social contexts into which they are emerging are considered. (b) When this is done, a host of significant social context issues, or…

  16. Nanotechnology at KT

    DEFF Research Database (Denmark)

    Glarborg, Peter; Hassager, Ole; Jonsson, Gunnar Eigil;

    2002-01-01

    The objective of this report is to provide the reader an overview of the research activities at the Department of Chemical Engineering in the area of "nanotechnology"......The objective of this report is to provide the reader an overview of the research activities at the Department of Chemical Engineering in the area of "nanotechnology"...

  17. Nanotechnologies for sustainable construction

    DEFF Research Database (Denmark)

    Geiker, Mette Rica; Andersen, Maj Munch

    2009-01-01

    This chapter aims to highlight key aspects and recent trends in the development and application of nanotechnology to facilitate sustainable construction, use and demolition of buildings and infrastructure structures, ‘nanoconstruction’. Nanotechnology is not a technology but a very diverse...

  18. Nanotechnology in ophthalmology.

    Science.gov (United States)

    Zarbin, Marco A; Montemagno, Carlo; Leary, James F; Ritch, Robert

    2010-10-01

    Nanotechnology involves the creation and use of materials and devices at the size scale of intracellular structures and molecules, and involves systems and constructs in the order of nanotechnology as applied to nanomedicine (e.g., biomimicry and pseudointelligence). Some applications of nanotechnology to ophthalmology are described (including treatment of oxidative stress; measurement of intraocular pressure; theragnostics; use of nanoparticles to treat choroidal new vessels, prevent scarring after glaucoma surgery, and treat retinal degenerative disease with gene therapy; prosthetics; and regenerative nanomedicine). Nanotechnology will revolutionize our approach to current therapeutic challenges (e.g., drug delivery, postoperative scarring) and will enable us to address currently unsolvable problems (e.g., sight-restoring therapy for patients with retinal degenerative disease). Obstacles to the incorporation of nanotechnology remain, such as safe manufacturing techniques and unintended biological consequences of nanomaterial use. These obstacles are not insurmountable, and revolutionary treatments for ophthalmic diseases are expected to result from this burgeoning field.

  19. Ethical issues in nanotechnology.

    Science.gov (United States)

    Florczyk, Stephen J; Saha, Subrata

    2007-01-01

    Nanotechnology is a rapidly developing area in science involved with manipulating matter at the atomic or molecular level. Nanotechnology is typically defined at a scale on the order of less than approximately 100 nm. Matter possesses unique properties at these size levels that are neither Newtonian nor quantum, but between the two regimes.These unique properties have created significant interest and excitement, sparking numerous research investigations. Nanotechnology is a very broad field with many current and potential applications. Some important examples of applications include battlefield activated dynamic armor clothing for soldiers, additives to sunscreens, and diagnostic laboratories on a chip to monitor general personal health. Groundbreaking capabilities often raise new questions. Any new scientific or technological development has the usual concomitant associated ethical issues, specifically regarding containment and regulation. These ethical issues are more pronounced with nanotechnology due to the sharp divide between those who see its great potential and opponents who express fears. Nanotechnology supporters believe that it has the potential to transform our lives dramatically, while opponents of nanotechnology fear that self-replicating "nanobots" could escape from laboratories and reduce all life on earth to "gray goo. "These fears have swayed generally uninformed public opinions via the media and sensational entertainment. A critical discussion of ethical issues surrounding nanotechnology, including the interaction of nanotechnology with the body and the environment--nanobiotechnology--and regulation of nanotechnology, is presented. We advocate strong, uniform regulations for nanotechnology, but only the use of regulations as needed. The limited use of regulations prevents the regulations from becoming burdensome and inhibiting research in the field.

  20. EDITORIAL: Nanotechnology under the skin Nanotechnology under the skin

    Science.gov (United States)

    Demming, Anna

    2011-07-01

    Concerns over health and ecological implications as living organisms are increasingly exposed to nanoparticles are constantly raised. Yet the use of nanoscale structures in technology and medicine has already infiltrated daily life in countless ways. from cosmetics and sun cream to mobile phones. The potential of nanotechnology in medicine is particularly difficult to ignore and ranges from cancer treatment to immune system activation [1]. The reduced dimensions of nanostructures lend them to targeted diagnostic and therapeutic practices that enable treatment with greater accuracy and less discomfort. Striking a balance between over caution and recklessness can be tricky, and provides an additional drive to investigate and learn more about the science of the nanoscale. Alongside investigations to exploit nanoparticles in medicine and technology, there have been a substantial number of studies to investigate the possible effects on our health, as well as some studies on the environmental ramifications. Researchers in the US have investigated the effects on aquatic life of ZnO nanoparticles, which may pollute lakes and rivers through accidental release during fabrication or as wash out from consumer materials [2]. The study is focused on zebrafish during early development. Zhu et al observe that while there may be evidence that Zn2+ ions and ZnO nanoparticles have toxic effects on zebrafish embryos, these effects are apparently mitigated by a type of sediment formulated from the nanoparticles. The positive contribution of nanotechnology in cancer treatment is an area of particularly high research activity at present. Although traditional chemotherapeutic agents can be effective against the growth of cancerous cells, they can have a detrimental effect on the immune system, which is critical in combating cancer. Researchers in China studied the behaviour of C60(OH)20 nanoparticles in vivo and found that they play important roles in the anti-tumour process by activating

  1. Nanotechnology for missiles

    Science.gov (United States)

    Ruffin, Paul B.

    2004-07-01

    Nanotechnology development is progressing very rapidly. Several billions of dollars have been invested in nanoscience research since 2000. Pioneering nanotechnology research efforts have been primarily conducted at research institutions and centers. This paper identifies developments in nanoscience and technology that could provide significant advances in missile systems applications. Nanotechnology offers opportunities in the areas of advanced materials for coatings, including thin-film optical coatings, light-weight, strong armor and missile structural components, embedded computing, and "smart" structures; nano-particles for explosives, warheads, turbine engine systems, and propellants to enhance missile propulsion; nano-sensors for autonomous chemical detection; and nano-tube arrays for fuel storage and power generation. The Aviation and Missile Research, Development, and Engineering Center (AMRDEC) is actively collaborating with academia, industry, and other Government agencies to accelerate the development and transition of nanotechnology to favorably impact Army Transformation. Currently, we are identifying near-term applications and quantifying requirements for nanotechnology use in Army missile systems, as well as monitoring and screening research and developmental efforts in the industrial community for military applications. Combining MicroElectroMechanical Systems (MEMS) and nanotechnology is the next step toward providing technical solutions for the Army"s transformation. Several research and development projects that are currently underway at AMRDEC in this technology area are discussed. A top-level roadmap of MEMS/nanotechnology development projects for aviation and missile applications is presented at the end.

  2. What Is the Role of Nanotechnology in Diagnosis and Treatment of Metastatic Breast Cancer? Promising Scenarios for the Near Future

    OpenAIRE

    Marta, Truffi; Luca, Sorrentino; Serena, Mazzucchelli; Luisa, Fiandra; Fabio, Corsi

    2016-01-01

    Metastatic breast cancer represents a diagnostic and therapeutic challenge due to tumor heterogeneity and to various physiological barriers that hinder drug delivery to the metastatic sites. To overcome these limitations, nanoformulated drugs have been developed and tested in preclinical studies, and few of them have been successfully translated into clinical practice. In particular, liposomal anthracyclines and nanoformulated albumin-bound paclitaxel have revealed an improved therapeutic ind...

  3. 76 FR 66932 - The National Cancer Institute (NCI) Announces the Initiation of a Public Private Industry...

    Science.gov (United States)

    2011-10-28

    ... Initiation of a Public Private Industry Partnership on Translation of Nanotechnology in Cancer (TONIC) To Promote Translational Research and Development Opportunities of Nanotechnology-Based Cancer Solutions... industry partnership called TONIC (Translation Of Nanotechnology In Cancer) to promote...

  4. Nanotechnology - The New Frontier of Medicine.

    Science.gov (United States)

    Datta, R; Jaitawat, S S

    2006-07-01

    Molecular nanotechnology is destined to become the core technology in 21(st) century medicine. Nanotechnology mean, controlling biologically relevant structures with molecular precision. Nanomedicine is exploring how to use carbon buckyballs, dendrimers and other cleverly engineered nanoparticles in novel drugs to combat viruses, bacteria, cancer and delivery of drugs. Medical nanorobots will be of the size of a microbe, capable of self-replication, containing onboard sensors, computers, manipulators, pumps, pressure tanks and power supplies. Building such sophisticated molecular machine systems will require molecular manufacturing to using massively parallel assembly lines in nanofactories.

  5. Nanotechnology: The future medicine

    Directory of Open Access Journals (Sweden)

    Rajiv Saini

    2010-01-01

    Full Text Available Nanotechnology is an exciting new area in science, with many possible applications in medicine. This article seeks to outline the role of different areas such as diagnosis of diseases, drug delivery, imaging, and so on.

  6. Chiral Nanoscience and Nanotechnology

    OpenAIRE

    Dibyendu S. Bag; T.C. Shami; K.U. Bhasker Rao

    2008-01-01

    The paper reviews nanoscale science and technology of chiral molecules/macromolecules-under twosubtopics-chiral nanotechnology and nano-chiral technology. Chiral nanotechnology discusses thenanotechnology, where molecular chirality plays a role in the properties of materials, including molecularswitches, molecular motors, and other molecular devices; chiral supramolecules and self-assembled nanotubesand their functions are also highlighted. Nano-chiral technology  describes the nanoscale appr...

  7. Nanotechnology and Technomoral Change

    OpenAIRE

    Swierstra, Tsjalling

    2013-01-01

    If nanotechnology lives up to its revolutionary promises, do we then need a ‘new’ type of ethics to guide this technological development? After distinguishing different senses in which ethics could be ‘new’, I focus on the phenomenon of TechnoMoral Change. Emerging technologies like nanotechnology have the potential to destabilize established moral norms and values. This is relevant because those norms and values are needed to discuss whether technological developments are desirable or not. I...

  8. NANOTECHNOLOGY IN CONSTRUCTION

    OpenAIRE

    Saeli, .

    2011-01-01

    Nanotechnology, which has a vast number of possibilities in construction, ranging from energy conservation and coatings to structural enhancement and stress monitoring, has not yet made an important difference in construction compared to other major industries even when there has been a big progress in awareness and investigation in the last years. Nanotechnology has the potential to extend the limits of construction bringing new and enhanced products that can foster the construction activity...

  9. Taking nanotechnology to schools

    CERN Document Server

    Lakhtakia, A

    2006-01-01

    After a primer on nanotechnology and a review of current educational practices in secondary schools, the concept of just-in-time education is proposed to integrate technosciences and humanities so that both future technoscientists and non-technoscientists develop a common understanding, possibly even a common language, to deal with social, ethical, legal, and political issues that arise from the development of nanotechnology and its convergence with other technoscientific developments.

  10. Nanotechnology and dentistry

    OpenAIRE

    Ozak, Sule Tugba; Ozkan, Pelin

    2013-01-01

    Nanotechnology deals with the physical, chemical, and biological properties of structures and their components at nanoscale dimensions. Nanotechnology is based on the concept of creating functional structures by controlling atoms and molecules on a one-by-one basis. The use of this technology will allow many developments in the health sciences as well as in materials science, bio-technology, electronic and computer technology, aviation, and space exploration. With developments in materials sc...

  11. Effect of Nanotechnology

    OpenAIRE

    D. Baswaraj; Vasanthi; Sareddy Deepthi; Mohammad Zainuddin

    2012-01-01

    In this paper, we will put forward the vast effect on nanotechnology in various fields. A basic definition of Nanotechnology is the study manipulation and manufacture of extremely minute machines or devices. The future of technology at times becomes easier to predict. Computers will compute faster, materials will become stronger and medicine will cure more diseases .the technology that works at the nanometer scale of molecules and atoms will be a large part of this future, enabling great impr...

  12. Nanotechnology in dentistry.

    Science.gov (United States)

    Saravana, Kumar R; Vijayalakshmi, R

    2006-01-01

    Nanotechnology is manipulating matter at nanometer level and the application of the same to medicine is called nanomedicine. Nanotechnology holds promise for advanced diagnostics, targeted drug delivery, and biosensors. In the long-term, medical nanorobots will allow instant pathogen diagnosis and extermination, individual cell surgery in vivo, and improvement of natural physiological function. Current research is focusing on fabrication of nanostructures, nanoactuators, and nanomotors, along with means to assemble them into larger systems, economically and in great numbers.

  13. Nanotechnology in dentistry

    Directory of Open Access Journals (Sweden)

    Kumar Saravana

    2006-01-01

    Full Text Available Nanotechnology is manipulating matter at nanometer level and the application of the same to medicine is called nanomedicine. Nanotechnology holds promise for advanced diagnostics, targeted drug delivery, and biosensors. In the long-term, medical nanorobots will allow instant pathogen diagnosis and extermination, individual cell surgery in vivo, and improvement of natural physiological function. Current research is focusing on fabrication of nanostructures, nanoactuators, and nanomotors, along with means to assemble them into larger systems, economically and in great numbers.

  14. Future of Computing. Nanotechnology

    Directory of Open Access Journals (Sweden)

    Florin Frant

    2006-10-01

    Full Text Available Nanotechnology is a field of applied science and technology covering a broad range of topics. The impetus for nanotechnology has stemmed from a renewed interest in colloidal science, coupled with a new generation of analytical tools such as the atomic force microscope (AFM and the scanning tunneling microscope (STM. Combined with refined processes such as electron beam lithography, these instruments allow the deliberate manipulation of nanostructures, and in turn led to the observation of novel phenomena.

  15. Nanotechnology for telecommunications

    CERN Document Server

    Anwar, Sohail; Qazi, Salahuddin; Ilyas, Mohammad

    2010-01-01

    With its unique promise to revolutionize science, engineering, technology, and other fields, nanotechnology continues to profoundly impact associated materials, components, and systems, particularly those used in telecommunications. These developments are leading to easier convergence of related technologies, massive storage data, compact storage devices, and higher-performance computing. Nanotechnology for Telecommunications presents vital technical scientific information to help readers grasp issues and challenges associated with nanoscale telecommunication system development and commerciali

  16. Nanotechnology and medicine.

    Science.gov (United States)

    Emerich, Dwaine F; Thanos, Christopher G

    2003-07-01

    Nanotechnology, or systems/device manufacture at the molecular level, is a multidisciplinary scientific field undergoing explosive development. The genesis of nanotechnology can be traced to the promise of revolutionary advances across medicine, communications, genomics and robotics. On the surface, miniaturisation provides cost effective and more rapidly functioning mechanical, chemical and biological components. Less obvious though is the fact that nanometre sized objects also possess remarkable self-ordering and assembly behaviours under the control of forces quite different from macro objects. These unique behaviours are what make nanotechnology possible, and by increasing our understanding of these processes, new approaches to enhancing the quality of human life will surely be developed. A complete list of the potential applications of nanotechnology is too vast and diverse to discuss in detail, but without doubt one of the greatest values of nanotechnology will be in the development of new and effective medical treatments (i.e., nanomedicine). This review focuses on the potential of nanotechnology in medicine, including the development of nanoparticles for diagnostic and screening purposes, artificial receptors, DNA sequencing using nanopores, manufacture of unique drug delivery systems, gene therapy applications and the enablement of tissue engineering. PMID:12831370

  17. Nanotechnology in dentistry

    Directory of Open Access Journals (Sweden)

    Melanie Sadono Djamil

    2007-06-01

    Full Text Available Technology has continuously improved along with the complexity of devices. Nowadays, it is widely accepted that micro-technology, which is defined as a further reduction in the size of interconnections and components, is achieved by a conventional “top-down” method. We have now moved to a new concept and approach for fabrication from small to bigger building-block elements, which is called nanotechnology. Nanotechnology is the fabrication technology of tiny parts that is achieved by a “bottom-up” method. Nanotechnology has been developed in many areas of life sciences, such as in dentistry. This presentation provides some examples that illustrate the progress in technological growth, especially in the nanoscale. In the developments of nanotechnology, we are also concerned in many ways about its ethics and the laws of physics. The expansion in nanotechnology shows that much multidisciplinary research is being done in the nanoscale area. In dentistry, one of the examples is research in dental materials such as nanoleakage types in the use of various adhesives with resin composition. Nanodiagnostics are nanotechnology in applied molecular diagnostics. All these fields have applications in diagnostics and in point-of-care hand-held devices.

  18. Targeted anticancer therapy: overexpressed receptors and nanotechnology.

    Science.gov (United States)

    Akhtar, Mohd Javed; Ahamed, Maqusood; Alhadlaq, Hisham A; Alrokayan, Salman A; Kumar, Sudhir

    2014-09-25

    Targeted delivery of anticancer drugs to cancer cells and tissues is a promising field due to its potential to spare unaffected cells and tissues, but it has been a major challenge to achieve success in these therapeutic approaches. Several innovative approaches to targeted drug delivery have been devised based on available knowledge in cancer biology and on technological advancements. To achieve the desired selectivity of drug delivery, nanotechnology has enabled researchers to design nanoparticles (NPs) to incorporate anticancer drugs and act as nanocarriers. Recently, many receptor molecules known to be overexpressed in cancer have been explored as docking sites for the targeting of anticancer drugs. In principle, anticancer drugs can be concentrated specifically in cancer cells and tissues by conjugating drug-containing nanocarriers with ligands against these receptors. Several mechanisms can be employed to induce triggered drug release in response to either endogenous trigger or exogenous trigger so that the anticancer drug is only released upon reaching and preferentially accumulating in the tumor tissue. This review focuses on overexpressed receptors exploited in targeting drugs to cancerous tissues and the tumor microenvironment. We briefly evaluate the structure and function of these receptor molecules, emphasizing the elegant mechanisms by which certain characteristics of cancer can be exploited in cancer treatment. After this discussion of receptors, we review their respective ligands and then the anticancer drugs delivered by nanotechnology in preclinical models of cancer. Ligand-functionalized nanocarriers have delivered significantly higher amounts of anticancer drugs in many in vitro and in vivo models of cancer compared to cancer models lacking such receptors or drug carrying nanocarriers devoid of ligand. This increased concentration of anticancer drug in the tumor site enabled by nanotechnology could have a major impact on the efficiency of cancer

  19. 1979-1999 twenty research years and one answer. No relationship between child cancers and exposure to magnetic field

    International Nuclear Information System (INIS)

    The study provides no evidence that exposure to magnetic fields associated with the electricity supply in the UK increases risks for childhood leukaemia, cancers of the central nervous system, or any other childhood cancer. The british study is the most important study on this subject in the world because it has compared 2226 children with a cancer to the same number of good health children, with the same age, residence and sex. It has be made independently from electric power industry. It was also a complex study because it needed to collect blood samples near children and their family to determine their immunological and genetic characteristics, a precise dosimetry to register the exposure to ionizing radiations and to magnetic fields, and a validation of histological diagnosis of the different tumors. The end word is given to Sir Richard Doll (epidemiologist) ' It is now time to consider that the Kinlen hypothesis, attributing the acute childhood leukaemia to the populations mixing is established'. (N.C.)

  20. Can animal and in vitro studies give new, relevant answers to questions concerning mammographic screening for human breast cancer

    International Nuclear Information System (INIS)

    First, we recommend that no further animal population carcinogenesis studies aimed at quantifying the risk per rad be initiated at this time. This strong recommendation is based on: (1) the fact that human breast radiation-carcinogenesis data already exist from several studies, and quantitative estimates of risk that can be made from these data are directly relevant to the mammography situtation; (2) the serious questions about the validity of direct extrapolation from the current rodent models that have the necessary base-line data already established; and (3) the difficulty and expense involved in conducting a large rodent experiment with fractionated low-dose protocols comparable to X-ray mammography. Second, in contrast to the animal population studies, we do recommend that the Breast Cancer Task Force seriously consider funding new studies to evaluate the cellular and molecular events relating to carcinogenesis. These specifically should be focused on the intriguing evidence suggesting that (1) the risk per rad may actually be higher at fractionated low doses than at higher doses, and (2) women at higher risk from other factors (e.g., age, genetic, hormonal) may actually be at a higher risk for X-irradiation carcinogenesis than are women at low risk to the other factors. The studies recommended above are obviously aimed at the basic mechanism of X-ray carcinogenesis and cocarcinogenesis, and the results would most likely have direct application to X-ray carcinogenesis in general as well as radiation-induced breast cancer per se

  1. Nanotechnology in corneal neovascularization therapy--a review.

    Science.gov (United States)

    Gonzalez, Lilian; Loza, Raymond J; Han, Kyu-Yeon; Sunoqrot, Suhair; Cunningham, Christy; Purta, Patryk; Drake, James; Jain, Sandeep; Hong, Seungpyo; Chang, Jin-Hong

    2013-03-01

    Nanotechnology is an up-and-coming branch of science that studies and designs materials with at least one dimension sized from 1-100 nm. These nanomaterials have unique functions at the cellular, atomic, and molecular levels. The term "nanotechnology" was first coined in 1974. Since then, it has evolved dramatically and now consists of distinct and independent scientific fields. Nanotechnology is a highly studied topic of interest, as nanoparticles can be applied to various fields ranging from medicine and pharmacology, to chemistry and agriculture, to environmental science and consumer goods. The rapidly evolving field of nanomedicine incorporates nanotechnology with medical applications, seeking to give rise to new diagnostic means, treatments, and tools. Over the past two decades, numerous studies that underscore the successful fusion of nanotechnology with novel medical applications have emerged. This has given rise to promising new therapies for a variety of diseases, especially cancer. It is becoming abundantly clear that nanotechnology has found a place in the medical field by providing new and more efficient ways to deliver treatment. Ophthalmology can also stand to benefit significantly from the advances in nanotechnology research. As it relates to the eye, research in the nanomedicine field has been particularly focused on developing various treatments to prevent and/or reduce corneal neovascularization among other ophthalmologic disorders. This review article aims to provide an overview of corneal neovascularization, currently available treatments, and where nanotechnology comes into play.

  2. Nanotechnology in the Security

    CERN Document Server

    Kruchinin, Sergei

    2015-01-01

    The topics discussed at the NATO Advanced Research Workshop "Nanotechnology in the Security Systems" included nanophysics,   nanotechnology,  nanomaterials, sensors, biosensors security systems, explosive  detection . There have been many significant advances in the past two years and some entirely new directions of research are just opening up. Recent advances in nanoscience have demonstrated that fundamentally new physical phenomena  are found when systems are reduced in size with  dimensions, comparable to the fundamental microscopic  length scales of the investigated material. Recent developments in nanotechnology and measurement techniques now allow experimental investigation of transport properties of nanodevices. This work will be of interest to researchers working in spintronics, molecular electronics and quantum information processing.

  3. ACCELERATING NANO-TECHNOLOGICAL

    DEFF Research Database (Denmark)

    Jensen, Jens Stissing; Koch, Christian

    2007-01-01

    By viewing the construction industry as a technological innovation system (TIS) this paper discusses possible initiatives to accelerate nanotechnological innovations. The point of departure is a recent report on the application of nano-technology in the Danish construction industry, which concludes...... of the system are furthermore poorly equipped at identifying potentials within high-tech areas. In order to exploit the potentials of nano-technology it is thus argued that an alternative TIS needs to be established. Initiatives should identify and support “incubation rooms” or marked niches in order...... for the different elements of the TIS to evolve. This could involve nano-visioning including scenarios of future technological applications and industrial dynamics....

  4. The track nanotechnology

    International Nuclear Information System (INIS)

    The discipline now called Solid State Nuclear Track Detection (SSNTD) dates back to 1958 and has its roots in the United Kingdom. Its strength stems chiefly from factors such as its simplicity, small geometry, permanent maintenance of the nuclear record and other diversified applications. A very important field with exciting applications reported recently in conjuction with the nuclear track technique is nanotechnology, which has applications in biology, chemistry, industry, medicare and health, information technology, biotechnology, and metallurgical and chemical technologies. Nanotechnology requires material design followed by the study of the quantum effects for final produced applications in sensors, medical diagnosis, information technology to name a few. We, in this article, present a review of past and present applications of SSNTD suggesting ways to apply the technique in nanotechnology, with special reference to development of nanostructure for applications utilising nanowires, nanofilters and sensors.

  5. Artificial intelligence in nanotechnology.

    Science.gov (United States)

    Sacha, G M; Varona, P

    2013-11-15

    During the last decade there has been increasing use of artificial intelligence tools in nanotechnology research. In this paper we review some of these efforts in the context of interpreting scanning probe microscopy, the study of biological nanosystems, the classification of material properties at the nanoscale, theoretical approaches and simulations in nanoscience, and generally in the design of nanodevices. Current trends and future perspectives in the development of nanocomputing hardware that can boost artificial-intelligence-based applications are also discussed. Convergence between artificial intelligence and nanotechnology can shape the path for many technological developments in the field of information sciences that will rely on new computer architectures and data representations, hybrid technologies that use biological entities and nanotechnological devices, bioengineering, neuroscience and a large variety of related disciplines.

  6. Nanotechnology in radiation oncology.

    Science.gov (United States)

    Wang, Andrew Z; Tepper, Joel E

    2014-09-10

    Nanotechnology, the manipulation of matter on atomic and molecular scales, is a relatively new branch of science. It has already made a significant impact on clinical medicine, especially in oncology. Nanomaterial has several characteristics that are ideal for oncology applications, including preferential accumulation in tumors, low distribution in normal tissues, biodistribution, pharmacokinetics, and clearance, that differ from those of small molecules. Because these properties are also well suited for applications in radiation oncology, nanomaterials have been used in many different areas of radiation oncology for imaging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio. In this article, we review the unique properties of nanomaterials that are favorable for oncology applications and examine the various applications of nanotechnology in radiation oncology. We also discuss the future directions of nanotechnology within the context of radiation oncology.

  7. Artificial intelligence in nanotechnology

    International Nuclear Information System (INIS)

    During the last decade there has been increasing use of artificial intelligence tools in nanotechnology research. In this paper we review some of these efforts in the context of interpreting scanning probe microscopy, the study of biological nanosystems, the classification of material properties at the nanoscale, theoretical approaches and simulations in nanoscience, and generally in the design of nanodevices. Current trends and future perspectives in the development of nanocomputing hardware that can boost artificial-intelligence-based applications are also discussed. Convergence between artificial intelligence and nanotechnology can shape the path for many technological developments in the field of information sciences that will rely on new computer architectures and data representations, hybrid technologies that use biological entities and nanotechnological devices, bioengineering, neuroscience and a large variety of related disciplines. (topical review)

  8. Nanotechnology for chemical engineers

    CERN Document Server

    Salaheldeen Elnashaie, Said; Hashemipour Rafsanjani, Hassan

    2015-01-01

    The book describes the basic principles of transforming nano-technology into nano-engineering with a particular focus on chemical engineering fundamentals. This book provides vital information about differences between descriptive technology and quantitative engineering for students as well as working professionals in various fields of nanotechnology. Besides chemical engineering principles, the fundamentals of nanotechnology are also covered along with detailed explanation of several specific nanoscale processes from chemical engineering point of view. This information is presented in form of practical examples and case studies that help the engineers and researchers to integrate the processes which can meet the commercial production. It is worth mentioning here that, the main challenge in nanostructure and nanodevices production is nowadays related to the economic point of view. The uniqueness of this book is a balance between important insights into the synthetic methods of nano-structures and nanomaterial...

  9. The track nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Waheed, A. [British Institute of Technology and E-Commerce, London E7 9HZ (United Kingdom); Physics Department, University of Reading, Reading RG6 6AF (United Kingdom); Forsyth, D., E-mail: dforsyth@bite.ac.u [British Institute of Technology and E-Commerce, London E7 9HZ (United Kingdom); Watts, A. [Department of Physics, UCL, London Centre of Nanotechnology (LCN), 17-19 Gordon Street, London WC1H OAH (United Kingdom); Saad, A.F. [Physics Department, Faculty of Science, Garyounis University, Benghazi (Libyan Arab Jamahiriya); Mitchell, G.R. [British Institute of Technology and E-Commerce, London E7 9HZ (United Kingdom); Physics Department, University of Reading, Reading RG6 6AF (United Kingdom); Farmer, M. [British Institute of Technology and E-Commerce, London E7 9HZ (United Kingdom); Harris, P.J.F. [Physics Department, University of Reading, Reading RG6 6AF (United Kingdom)

    2009-10-15

    The discipline now called Solid State Nuclear Track Detection (SSNTD) dates back to 1958 and has its roots in the United Kingdom. Its strength stems chiefly from factors such as its simplicity, small geometry, permanent maintenance of the nuclear record and other diversified applications. A very important field with exciting applications reported recently in conjuction with the nuclear track technique is nanotechnology, which has applications in biology, chemistry, industry, medicare and health, information technology, biotechnology, and metallurgical and chemical technologies. Nanotechnology requires material design followed by the study of the quantum effects for final produced applications in sensors, medical diagnosis, information technology to name a few. We, in this article, present a review of past and present applications of SSNTD suggesting ways to apply the technique in nanotechnology, with special reference to development of nanostructure for applications utilising nanowires, nanofilters and sensors.

  10. Artificial intelligence in nanotechnology

    Science.gov (United States)

    Sacha, G. M.; Varona, P.

    2013-11-01

    During the last decade there has been increasing use of artificial intelligence tools in nanotechnology research. In this paper we review some of these efforts in the context of interpreting scanning probe microscopy, the study of biological nanosystems, the classification of material properties at the nanoscale, theoretical approaches and simulations in nanoscience, and generally in the design of nanodevices. Current trends and future perspectives in the development of nanocomputing hardware that can boost artificial-intelligence-based applications are also discussed. Convergence between artificial intelligence and nanotechnology can shape the path for many technological developments in the field of information sciences that will rely on new computer architectures and data representations, hybrid technologies that use biological entities and nanotechnological devices, bioengineering, neuroscience and a large variety of related disciplines.

  11. Nanotechnology in the marketplace: how the nanotechnology industry views risk

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Sean, E-mail: seanlouisbecker@gmail.com [University of Wisconsin-Madison (United States)

    2013-05-15

    Despite uncertainty about the potential human health and environmental risks of nanotechnology, major stakeholders such as regulatory agencies and the nanotechnology industry are already negotiating the emerging regulatory framework for nanotechnology. Because of a relative lack of nano-specific regulations, the future of nanotechnology development will depend greatly on the views held by the nanotechnology industry. This study fills the research gap in understanding how the nanotechnology industry perceives the risks of nanotechnology. This is the first interview-based study of the nanotechnology industry in the United States. Semi-structured, open-ended phone interviews were conducted with 17 individuals involved in the commercialization of nanotechnology in the United States. Results indicate that while the industry acknowledges uncertainty about the potential risks of nanotechnology and takes significant precaution in ensuring the safety of their products, they do not see nanotechnology as novel or risky. They do not believe that uncertainty over risk ought to delay the further development of nanotechnology. The industry sees itself as the primary agent in ensuring consumer safety and believes that consumers are adequately protected. They are also largely benefit-centric and view product labeling as inefficacious.

  12. Broadening nanotechnology's impact on development

    Science.gov (United States)

    Beumer, Koen

    2016-05-01

    Discussions about nanotechnology and development focus on applications that directly address the needs of the world's poor. Nanotechnology can certainly make an impact in the fight against global poverty, but we need to broaden our imagination.

  13. Understanding the nanotechnology revolution

    CERN Document Server

    Wolf, Edward L

    2012-01-01

    This is a unique introduction for general readers to the underlying concepts of nanotechnology, covering a wide spectrum ranging from biology to quantum computing. The material is presented in the simplest possible way, including a few mathematical equations, but not mathematical derivations. It also outlines as simply as possible the major contributions to modern technology of physics-based nanophysical devices, such as the atomic clock, global positioning systems, and magnetic resonance imaging. As a result, readers are able to establish a connection between nanotechnology and day-to-day

  14. Contextualising Nanotechnology in Chemistry Education

    OpenAIRE

    O'Connor, Christine; Hayden, Hugh

    2008-01-01

    This paper will give an example of a pedagogical approach taken in integrating nanotechnology into a chemistry degree course. In recent years nanotechnology has widely become part of the course content for undergraduate chemistry and physics degree curriculum. How contextualised the delivery of the subject matter may vary. The role of contextualisation of nanotechnology in the delivery of the content is the main focus of this paper, as to date in Ireland and many other countries nanotechnolog...

  15. The Nanotechnology R(evolution)

    OpenAIRE

    Tahan, Charles

    2006-01-01

    Nanotechnology as a social concept and investment focal point has drawn much attention. Here we consider the place of nanotechnology in the second great technological revolution of mankind that began some 200 years ago. The so-called nanotechnology revolution represents both a continuation of prior science and technology trends and a re-awakening to the benefits of significant investment in fundamental research. We consider the role the military might play in the development of nanotechnology...

  16. Contextualising Nanotechnology in Chemistry Education

    Science.gov (United States)

    O'Connor, Christine; Hayden, Hugh

    2008-01-01

    In recent years nanotechnology has become part of the content of many undergraduate chemistry and physics degree courses. This paper deals with the role of contextualisation of nanotechnology in the delivery of the content, as nanotechnology is only now being slowly integrated into many chemistry degree courses in Ireland and elsewhere. An…

  17. Nanotechnology: From Feynman to Funding

    Science.gov (United States)

    Drexler, K. Eric

    2004-01-01

    The revolutionary Feynman vision of a powerful and general nanotechnology, based on nanomachines that build with atom-by-atom control, promises great opportunities and, if abused, great dangers. This vision made nanotechnology a buzzword and launched the global nanotechnology race. Along the way, however, the meaning of the word has shifted. A…

  18. Exploiting developments in nanotechnology for the preferential delivery of platinum-based anti-cancer agents to tumours: targeting some of the hallmarks of cancer.

    Science.gov (United States)

    Parker, James P; Ude, Ziga; Marmion, Celine J

    2016-01-01

    Platinum drugs as anti-cancer therapeutics are held in extremely high regard. Despite their success, there are drawbacks associated with their use; their dose-limiting toxicity, their limited activity against an array of common cancers and patient resistance to Pt-based therapeutic regimes. Current investigations in medicinal inorganic chemistry strive to offset these shortcomings through selective targeting of Pt drugs and/or the development of Pt drugs with new or multiple modes of action. A comprehensive overview showcasing how liposomes, nanocapsules, polymers, dendrimers, nanoparticles and nanotubes may be employed as vehicles to selectively deliver cytotoxic Pt payloads to tumour cells is provided.

  19. Stromal response to prostate cancer: nanotechnology-based detection of thioredoxin-interacting protein partners distinguishes prostate cancer associated stroma from that of benign prostatic hyperplasia.

    Directory of Open Access Journals (Sweden)

    Elizabeth Singer

    Full Text Available Histological staining of reactive stroma has been shown to be a predictor of biochemical recurrence in prostate cancer, however, molecular markers of the stromal response to prostate cancer have not yet been fully delineated. The objective of this study was to determine whether or not the stromal biomarkers detected with a thioredoxin-targeted nanodevice could be used to distinguish the stroma associated with benign prostatic hyperplasia from that associated with PCA. In this regard, we recently demonstrated that a thioredoxin-targeted nanodevice selectively binds to reactive stroma in frozen prostate tumor tissue sections. To accomplish this, random frozen prostate tissue sections from each of 35 patients who underwent resection were incubated with the nanodevice and graded for fluorescent intensity. An adjacent section from each case was stained with Hematoxylin & Eosin to confirm the diagnosis. Select cases were stained with Masson's Trichrome or immunohistochemically using antibodies to thioredoxin reductase 1, thioredoxin reductase 2 or peroxiredoxin 1. Our results demonstrate that the graded intensity of nanodevice binding to the stroma associated with PCA was significantly higher (p = 0.0127 than that of benign prostatic hyperplasia using the t-test. Immunohistochemical staining of adjacent sections in representative cases showed that none of the two commonly studied thioredoxin interacting protein partners mirrored the fluorescence pattern seen with the nanodevice. However, thioredoxin reductase 2 protein was clearly shown to be a biomarker of prostate cancer-associated reactive stroma whose presence distinguishes the stroma associated with benign prostatic hyperplasia from that associated with prostate cancer. We conclude that the signal detected by the nanodevice, in contrast to individual targets detected with antibodies used in this study, originates from multiple thioredoxin interacting protein partners that distinguish the M2

  20. Materials and Nanotechnology

    International Nuclear Information System (INIS)

    The Materials and Nanotechnology Program is divided into subprograms in the following areas: Ceramic Materials, Composite Materials, Metallic Materials, Physical / Chemical Characterization and Nanomaterials. The subprograms are further divided in to broad topics in research, development and innovations. Within each topic, several R and D projects are carried out

  1. Nanotechnology - An emerging technology

    Science.gov (United States)

    Buckingham, D.

    2007-01-01

    The science of nanotechnology is still in its infancy. However, progress is being made in research and development of potential beneficial properties of nanomaterials that could play an integral part in the development of new and changing uses for mineral commodities. Nanotechnology is a kind of toolbox that allows industry to make nanomaterials and nanostructures with special properties. New nanotechnology applications of mineral commodities in their nanoscale form are being discovered, researched and developed. At the same time, there is continued research into environmental, human health and safety concerns that inherently arise from the development of a new technology. Except for a few nanomaterials (CNTs, copper, silver and zinc oxide), widespread applications are hampered by processing and suitable commercial-scale production techniques, high manufacturing costs, product price, and environmental, and human health and safety concerns. Whether nanotechnology causes a tidal wave of change or is a long-term evolutionary process of technology, new applications of familiar mineral commodities will be created. As research and development continues, the ability to manipulate matter at the nanoscale into increasingly sophisticated nanomaterials will improve and open up new possibilities for industry that will change the flow and use of mineral commodities and the materials and products that are used.

  2. Materials and Nanotechnology

    International Nuclear Information System (INIS)

    The focus of the Materials and Nanotechnology Program is technology development related to processing, analysis, testing and characterization of materials in general. The Program is divided into subprograms in broad areas such as ceramic, composite and metallic materials as well as characterization of physical and chemical properties of materials

  3. Nanotechnology in Agriculture

    Science.gov (United States)

    An overview is given of the application of nanotechnology to agriculture. This is an active field of R&D, where a large number of findings and innovations have been reported. For example, in soil management, applications reported include nanofertilizers, soil binders, water retention aids, and nut...

  4. Nanotechnology: Principles and Applications

    Science.gov (United States)

    Logothetidis, S.

    Nanotechnology is one of the leading scientific fields today since it combines knowledge from the fields of Physics, Chemistry, Biology, Medicine, Informatics, and Engineering. It is an emerging technological field with great potential to lead in great breakthroughs that can be applied in real life. Novel nano- and biomaterials, and nanodevices are fabricated and controlled by nanotechnology tools and techniques, which investigate and tune the properties, responses, and functions of living and non-living matter, at sizes below 100 nm. The application and use of nanomaterials in electronic and mechanical devices, in optical and magnetic components, quantum computing, tissue engineering, and other biotechnologies, with smallest features, widths well below 100 nm, are the economically most important parts of the nanotechnology nowadays and presumably in the near future. The number of nanoproducts is rapidly growing since more and more nanoengineered materials are reaching the global market The continuous revolution in nanotechnology will result in the fabrication of nanomaterials with properties and functionalities which are going to have positive changes in the lives of our citizens, be it in health, environment, electronics or any other field. In the energy generation challenge where the conventional fuel resources cannot remain the dominant energy source, taking into account the increasing consumption demand and the CO2 emissions alternative renewable energy sources based on new technologies have to be promoted. Innovative solar cell technologies that utilize nanostructured materials and composite systems such as organic photovoltaics offer great technological potential due to their attractive properties such as the potential of large-scale and low-cost roll-to-roll manufacturing processes The advances in nanomaterials necessitate parallel progress of the nanometrology tools and techniques to characterize and manipulate nanostructures. Revolutionary new approaches

  5. Nanotechnology for sustainable energy

    Energy Technology Data Exchange (ETDEWEB)

    Serrano, Elena [Molecular Nanotechnology Laboratory, University of Alicante, Carretera Alicante-San Vicente s/n, E-03690 Alicante (Spain); Rus, Guillermo; Garcia-Martinez, Javier [Dpt. Structural Mechanics, University of Granada, Politecnico de Fuentenueva, 18071 Granada (Spain)

    2009-12-15

    Nanotechnology is generating a lot of attention these days and therefore building great expectations not only in the academic community but also among investors, the governments, and industry. Its unique capability to fabricate new structures at atomic scale has already produced novel materials and devices with great potential applications in a wide number of fields. Among them, significant breakthroughs are especially required in the energy sector that will allow us to maintain our increasing appetite for energy, which increases both with the number of people that join the developed economies and with our demand per capita. This needs to be done in a way that includes the environment in the wealth production equation as we gather more evidences of the human impact on the climate, biodiversity and quality of the air, water and soil. This review article does not cover in detail all the specific contributions from nanotechnology to the various sustainable energies, but in a broader way, it collects the most recent advances of nanotechnology to sustainable energy production, storage and use. For this review paper, solar, hydrogen and new generation batteries and supercapacitors are described as the most significant examples of the contributions of nanotechnology in the energy sector. The aim of this review article is to present some significant contributions from many research groups who are mainly unconnected and are working from different viewpoints, to find solutions to one of the great challenges of our time, i.e., the production and use of energy, without compromising our environment, from one of the most exciting and multidisciplinary fields, nanotechnology. (author)

  6. Green Chemistry for Nanotechnology: Opportunities and Future Challenges

    International Nuclear Information System (INIS)

    Nanotechnology is a paradigm for emerging technologies and much talked about area of science. It is the technology of future and has revolutionized all fields of medicine, agriculture, environmental and electronics by providing abilities that would never have previously dreamt of. It is a unique platform of multidisciplinary approaches integrating diverse fields of engineering, biology, physics and chemistry. In recent years, nanotechnology has seen the fastest pace in its all aspects of synthesis methodologies and wide applications in all areas of medicine, agricultural, environmental, and electronics. It is the impact of nanotechnology approaches that new fields of nanomedicine, cancer nanotechnology, nanorobotics and nanoelectronics have been emerged and are flourishing with the advances in this expanding field. Nanotechnology holds the potential for pervasive and promising applications and getting significant attention and financial aids also. Although there are different definitions of nanotechnology, in broad prospective, nanotechnology can be described as designing or exploiting materials at nanometer dimensions (i.e., one dimension less than 100 nanometers). At nanoscale, substances have a larger surface area to volume ratio than conventional materials which is the prime reason behind their increased level of reactivity, improved and size tunable magnetic, optical and electrical properties and more toxicity also

  7. Green Chemistry for Nanotechnology: Opportunities and Future Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Preeti Nigam, Joshi, E-mail: ph.joshi@ncl.res.in [Combichem Bioresource Center, National Chemical Laboratory, Pune (India)

    2016-01-26

    Nanotechnology is a paradigm for emerging technologies and much talked about area of science. It is the technology of future and has revolutionized all fields of medicine, agriculture, environmental and electronics by providing abilities that would never have previously dreamt of. It is a unique platform of multidisciplinary approaches integrating diverse fields of engineering, biology, physics and chemistry. In recent years, nanotechnology has seen the fastest pace in its all aspects of synthesis methodologies and wide applications in all areas of medicine, agricultural, environmental, and electronics. It is the impact of nanotechnology approaches that new fields of nanomedicine, cancer nanotechnology, nanorobotics and nanoelectronics have been emerged and are flourishing with the advances in this expanding field. Nanotechnology holds the potential for pervasive and promising applications and getting significant attention and financial aids also. Although there are different definitions of nanotechnology, in broad prospective, nanotechnology can be described as designing or exploiting materials at nanometer dimensions (i.e., one dimension less than 100 nanometers). At nanoscale, substances have a larger surface area to volume ratio than conventional materials which is the prime reason behind their increased level of reactivity, improved and size tunable magnetic, optical and electrical properties and more toxicity also.

  8. Risk of nanotechnology

    Science.gov (United States)

    Louda, Petr; Bakalova, Totka

    2014-05-01

    Nano-this and nano-that. These days it seems you need the prefix "nano" for products or applications if you want to be either very trendy or incredibly scary. This "nano-trend" has assumed "mega" proportions. Vague promises of a better life are met by equally vague, generalized fears about a worse future. These debates have some aspects in common: the subject is complex and not easy to explain; there is no consensus on risks and benefits. - A particular problem with nanotechnology lies in the huge gap between the public perception of what the hype promises and the scientific and commercial reality of what the technology actually delivers today and in the near future. There is nanoscience, which is the study of phenomena and manipulation of material at the nanoscale, in essence an extension of existing sciences into the nanoscale. Then there is nanotechnology, which is the design, characterization, production and application of structures, devices and systems by controlling shape and size at the nanoscale. Nanotechnology should really be called nanotechnologies: There is no single field of nanotechnology. The term broadly refers to such fields as biology, physics or chemistry, any scientific field really, or a combination thereof, that deals with the deliberate and controlled manufacturing of nanostructures. In addressing the health and environmental impact of nanotechnology we need to differentiate two types of nanostructures: (1) Nanocomposites, nanostructured surfaces and nanocomponents (electronic, optical, sensors etc.), where nanoscale particles are incorporated into a substance, material or device ("fixed" nanoparticles); and (2) "free" nanoparticles, where at some stage in production or use individual nanoparticles of a substance are present. There are four entry routes for nanoparticles into the body: they can be inhaled, swallowed, absorbed through skin or be deliberately injected during medical procedures. Once within the body they are highly mobile and

  9. Nanotechnology Applications for Glaucoma.

    Science.gov (United States)

    Cetinel, Sibel; Montemagno, Carlo

    2016-01-01

    Glaucoma is the second leading cause of blindness worldwide, and the antiglaucoma treatments currently available suffer from various complications. Nanotechnology-based treatments show a great deal of promise in overcoming these complications and form the basis for next-generation glaucoma treatment strategies, with the help of applications such as controlled release, targeted delivery, increased bioavailability, diffusion limitations, and biocompatibility. Significant progress has been made in nanomedicine in the efficiency of antiglaucoma medications, nanofabrication systems such as microelectromechanical systems that remove the limitations of nanodevices, and tissue regeneration vesicles for developing glaucoma treatments not based on intraocular pressure. With the use of these advanced technologies, the prevention of glaucoma-induced blindness will be possible in the near future. Herein, we reviewed the recent advances in nanotechnology-based treatment strategies for glaucoma. PMID:26693592

  10. Nanotechnologies a general introduction

    CERN Document Server

    CERN. Geneva; Ferrari, M; Li Bassi, A

    2007-01-01

    After a brief description of what is nanotechnology (a triple definition will be attempted) and of its importance for the society, this first lecture manly aims at showing how nanoscience makes various nanotechnologies possible. The surprising story of direct imaging and manipulation of atoms (scanning probe microscopies will be the specific subject of the third lecture by prof. Andrea Li Bassi) is told to naturally introduce the crucial role of quantum confinement and surface defects. The electronic and vibrational properties of nanostructures are then discussed to understand the connection between the deeply modified (with respect to the bulk) quantum spectra and the physico-chemical properties of nanoscopic objects. In this context the concept of superatom (and its generalizations) is stressed. The essential role of both size and size control is finally emphasized discussing some significant applications in the fields of materials, devices and medicine. To this last argument (nanomedicine) the second lectu...

  11. Nanostructures and Nanotechnology

    Science.gov (United States)

    Natelson, Douglas

    2015-06-01

    Preface; 1. Introduction and overview; 2. Solid state physics in a nutshell; 3. Bulk materials; 4. Fabrication and characterization at the nanoscale; 5. Real solids: defects, interactions, confinement; 6. Charge transport and nanoelectronics; 7. Magnetism and magnetoelectronics; 8. Photonics; 9. Micro and nanomechanics; 10. Micro and nanofluidics; 11. Bionanotechnology: a very brief overview; 12. Nanotechnology and the future; Appendix: common quantum mechanics and statistical mechanics results; References; Index.

  12. Nanotechnology, nanotoxicology, and neuroscience

    OpenAIRE

    Suh, Won Hyuk; Suslick, Kenneth S.; Stucky, Galen D.; Suh, Yoo-hun

    2008-01-01

    Nanotechnology, which deals with features as small as a 1 billionth of a meter, began to enter into mainstream physical sciences and engineering some 20 years ago. Recent applications of nanoscience include the use of nanoscale materials in electronics, catalysis, and biomedical research. Among these applications, strong interest has been shown to biological processes such as blood coagulation control and multimodal bioimaging, which has brought about a new and exciting research field called ...

  13. Nanotechnology-Based Cosmeceuticals

    OpenAIRE

    Alka Lohani; Anurag Verma; Himanshi Joshi; Niti Yadav; Neha Karki

    2014-01-01

    Cosmeceuticals are the fastest growing segment of the personal care industry, and a number of topical cosmeceutical treatments for conditions such as photoaging, hyperpigmentation, wrinkles, and hair damage have come into widespread use. In the cosmeceutical arena nanotechnology has played an important role. Using new techniques to manipulate matter at an atomic or molecular level, they have been at the root of numerous innovations, opening up new perspectives for the future of cosmeceutical ...

  14. Nanomedicine, Nanotechnology in medicine

    OpenAIRE

    Boisseau, Patrick; Loubaton, Bertrand

    2011-01-01

    Nanomedicine is a relatively new field of science and technology. It looks sometimes ill defined and interpretations of that term may vary, especially between Europe and the United States. By interacting with biological molecules, therefore at nanoscale, nanotechnology opens up a vast field of research and application. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside the human cells. Operating at...

  15. Nanotechnology in dentistry: prevention, diagnosis, and therapy

    Directory of Open Access Journals (Sweden)

    Abou Neel EA

    2015-10-01

    Full Text Available Ensanya Ali Abou Neel,1–3 Laurent Bozec,3 Roman A Perez,4,5 Hae-Won Kim,4–6 Jonathan C Knowles3,5 1Division of Biomaterials, Operative Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia; 2Biomaterials Department, Faculty of Dentistry, Tanta University, Tanta, Egypt; 3UCL Eastman Dental Institute, Biomaterials and Tissue Engineering, London, UK; 4Institute of Tissue Regenerative Engineering (ITREN, 5Department of Nanobiomedical Science and BK21 Plus NBM Global Research Center for Regenerative Medicine, 6Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Republic of Korea Abstract: Nanotechnology has rapidly expanded into all areas of science; it offers significant alternative ways to solve scientific and medical questions and problems. In dentistry, nanotechnology has been exploited in the development of restorative materials with some significant success. This review discusses nanointerfaces that could compromise the longevity of dental restorations, and how nanotechnolgy has been employed to modify them for providing long-term successful restorations. It also focuses on some challenging areas in dentistry, eg, oral biofilm and cancers, and how nanotechnology overcomes these challenges. The recent advances in nanodentistry and innovations in oral health-related diagnostic, preventive, and therapeutic methods required to maintain and obtain perfect oral health, have been discussed. The recent advances in nanotechnology could hold promise in bringing a paradigm shift in dental field. Although there are numerous complex therapies being developed to treat many diseases, their clinical use requires careful consideration of the expense of synthesis and implementation. Keywords: nanotechnology, nanointerfaces, biofilm-related oral diseases, tissue engineering, drug delivery, toxicity

  16. Nanotechnology in Textiles.

    Science.gov (United States)

    Yetisen, Ali K; Qu, Hang; Manbachi, Amir; Butt, Haider; Dokmeci, Mehmet R; Hinestroza, Juan P; Skorobogatiy, Maksim; Khademhosseini, Ali; Yun, Seok Hyun

    2016-03-22

    Increasing customer demand for durable and functional apparel manufactured in a sustainable manner has created an opportunity for nanomaterials to be integrated into textile substrates. Nanomoieties can induce stain repellence, wrinkle-freeness, static elimination, and electrical conductivity to fibers without compromising their comfort and flexibility. Nanomaterials also offer a wider application potential to create connected garments that can sense and respond to external stimuli via electrical, color, or physiological signals. This review discusses electronic and photonic nanotechnologies that are integrated with textiles and shows their applications in displays, sensing, and drug release within the context of performance, durability, and connectivity. Risk factors including nanotoxicity, nanomaterial release during washing, and environmental impact of nanotextiles based on life cycle assessments have been evaluated. This review also provides an analysis of nanotechnology consolidation in the textiles market to evaluate global trends and patent coverage, supplemented by case studies of commercial products. Perceived limitations of nanotechnology in the textile industry and future directions are identified. PMID:26918485

  17. Nanotechnology and vaccine development

    Directory of Open Access Journals (Sweden)

    Mi-Gyeong Kim

    2014-10-01

    Full Text Available Despite the progress of conventional vaccines, improvements are clearly required due to concerns about the weak immunogenicity of these vaccines, intrinsic instability in vivo, toxicity, and the need for multiple administrations. To overcome such problems, nanotechnology platforms have recently been incorporated into vaccine development. Nanocarrier-based delivery systems offer an opportunity to enhance the humoral and cellular immune responses. This advantage is attributable to the nanoscale particle size, which facilitates uptake by phagocytic cells, the gut-associated lymphoid tissue, and the mucosa-associated lymphoid tissue, leading to efficient antigen recognition and presentation. Modifying the surfaces of nanocarriers with a variety of targeting moieties permits the delivery of antigens to specific cell surface receptors, thereby stimulating specific and selective immune responses. In this review, we introduce recent advances in nanocarrier-based vaccine delivery systems, with a focus on the types of carriers, including liposomes, emulsions, polymer-based particles, and carbon-based nanomaterials. We describe the remaining challenges and possible breakthroughs, including the development of needle-free nanotechnologies and a fundamental understanding of the in vivo behavior and stability of the nanocarriers in nanotechnology-based delivery systems.

  18. Nanotechnology based devices and applications in medicine: An overview

    Directory of Open Access Journals (Sweden)

    Elvis A Martis

    2012-01-01

    Full Text Available Nanotechnology has been the most explored and extensively studied area in recent times. Many devices which were earlier impossible to imagine, are being developed at a lightning speed with the application of nanotechnology. To overcome the challenges offered by the most dreaded diseases, such as cancer or any disease involving the central nervous system or other inaccessible areas of the human body, nanotechnology has been proved to be a boon in making the treatment more target specific and minimizing the toxicities. This review describes a handful of important devices and applications based on nanotechnology in medicine made in recent times. This article also describes in brief the regulatory concerns and the ethical issues pertaining to nanomedical devices.

  19. Nanomedicine, nanotechnology in medicine

    Science.gov (United States)

    Boisseau, Patrick; Loubaton, Bertrand

    2011-09-01

    Nanomedicine is a relatively new field of science and technology. It looks sometimes ill defined and interpretations of that term may vary, especially between Europe and the United States. By interacting with biological molecules, therefore at nanoscale, nanotechnology opens up a vast field of research and application. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside the human cells. Operating at nanoscale allows to exploit physical properties different from those observed at microscale such as the volume/surface ratio. The investigated diagnostic applications can be considered for in vitro as well as for in vivo diagnosis. In vitro, the synthesised particles and manipulation or detection devices allow for the recognition, capture, and concentration of biomolecules. In vivo, the synthetic molecular assemblies are mainly designed as a contrast agent for imaging. A second area exhibiting a strong development is "nanodrugs" where nanoparticles are designed for targeted drug delivery. The use of such carriers improves the drug biodistribution, targeting active molecules to diseased tissues while protecting healthy tissue. A third area of application is regenerative medicine where nanotechnology allows developing biocompatible materials which support growth of cells used in cell therapy. The application of nanotechnology to medicine raises new issues because of new uses they allow, for instance: Is the power of these new diagnostics manageable by the medical profession? What means treating a patient without any clinical signs? Nanomedicine can contribute to the development of a personalised medicine both for diagnosis and therapy. There exists in many countries existing regulatory frameworks addressing the basic rules of safety and effectiveness of nanotechnology based medicine, whether molecular assemblies or medical devices. However, there is a need to clarify or to

  20. Developing nanotechnology in Latin America

    OpenAIRE

    Kay, Luciano; Shapira, Philip

    2008-01-01

    This article investigates the development of nanotechnology in Latin America with a particular focus on Argentina, Brazil, Chile, and Uruguay. Based on data for nanotechnology research publications and patents and suggesting a framework for analyzing the development of R&D networks, we identify three potential strategies of nanotechnology research collaboration. Then, we seek to identify the balance of emphasis upon each of the three strategies by mapping the current research profile of those...

  1. Nanotechnologies in Latvia: Commercialisation Aspect

    OpenAIRE

    Geipele I.; Staube T.; Ciemleja G.; Ekmanis J.; Zeltins N.

    2014-01-01

    The authors consider the possibilities to apply the nanotechnology products of manufacturing industries in Latvia for further commercialisation. The purpose of the research is to find out the preliminary criteria for the system of engineering economic indicators for multifunctional nanocoating technologies. The article provides new findings and calculations for the local nanotechnology market research characterising the development of nanotechnology industry. The authors outline a scope of is...

  2. NANOTECHNOLOGY IN TEXTILE INDUSTRY [REVIEW

    OpenAIRE

    RATIU Mariana

    2015-01-01

    Nanoscience and nanotechnology are the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering. Nanotechnology overcomes the limitation of applying conventional methods to impart certain properties to textile materials. There is no doubt that in the next few years nanotechnology will penetrate into every area of the textile industry. Nanotextiles are nanoscale fibrous materials...

  3. The challenges of green nanotechnology

    OpenAIRE

    Miguel de la Guardia

    2014-01-01

    Nanomaterials have great impacts on life sciences; however, these advanced materials may induce inadvertant consequences. Thus, this editorial will highlight the futuristic challenges ingreen nanotechnology.

  4. Annotated Answer Set Programming

    OpenAIRE

    Straccia, Umberto

    2005-01-01

    We present Annotated Answer Set Programming, that extends the ex pressive power of disjunctive logic programming with annotation terms, taken from the generalized annotated logic programming framework.

  5. Nanotechnology in paper electronics

    Science.gov (United States)

    Demming, Anna; Österbacka, Professor Ronald; Han, Jin-Woo, Dr

    2014-03-01

    devices. If 'writing is thinking on paper' [15], it seems researchers are finding yet more powerful means of putting their ideas on paper. References [1] Barquinha P, Martins R, Pereira L and Fortunato E 2012 Transparent Oxide Electronics: From Materials to Devices (Chichester: Wiley) [2] Zocco A T, You H, Hagen J A and Steckl A J 2014 Pentacene organic thin film transistors on flexible paper and glass substrates Nanotechnology 25 094005 [3] Pereira L, Gaspar D, Guerin D, Delattre A, Fortunato E and Martins R 2014 The influence of fibril composition and dimension on the performance of paper gated oxide transistors Nanotechnology 25 094007 [4] Wu G, Wan C, Zhou J, Zhu L and Wan Q 2014 Low-voltage protonic/electronic hybrid indium-zinc-oxide synaptic transistors on paper substrates Nanotechnology 25 094001 [5] Shin H, Yoon B, Park I S and Kim J-M 2014 An electrothermochromic paper display based on colorimetrically reversible polydiacetylenes Nanotechnology 25 094011 [6] Ihalainen P, Pettersson F, Pesonen M, Viitala T, Määttänen A, Österbacka R and Peltonen J 2014 An impedimetric study of DNA hybridization on paper supported inkjet-printed gold electrodes Nanotechnology 25 094009 [7] Wang Y, Shi Y, Zhao C X, Wong J I, Sun X W and Yang H Y 2014 Printed all-solid flexible microsupercapacitors: towards the general route for high energy storage device Nanotechnology 25 094010 [8] Andersson H A, Manuilskiy A, Haller S, Hummelgård M, Sidén J, Hummelgård C, Olin H and Nilsson H-E 2014 Assembling surface mounted components on ink-jet printed double sided paper circuit board Nanotechnology 25 094002 [9] Gaspar D, Fernandes S N, de Oliveira A G, Fernandes J G, Grey P, Pontes R V, Pereira L, Martins R, Godinho M H and Fortunato E 2014 Nanocrystalline cellulose applied simultaneously as gate dielectric and substrate on flexible field effect transistors Nanotechnology 25 094008 [10] Männl U, van den Berg C, Magunje B, Härting M, Britton D T, Jones S, Mvan Staden M J and Scriba M

  6. Nanotechnology and society

    International Nuclear Information System (INIS)

    Past experience has shown that the successful introduction of a new technology requires careful attention to the interactions between the technology and society. These interactions are bi-directional: on the one hand, technology changes and challenges social patterns and, on the other hand, the governance structures and values of the society affect progress in developing the technology. Nanotechnology is likely to be particularly affected by these kinds of interactions because of its great promise and the unusually early public attention it has received. Moreover, it represents a new kind of experiment in packaging a rather wide range of fundamental research activities under a single 'mission-like' umbrella. Although this gives it more impetus as a field, it sets a higher bar for showing successful applications early on and because it links disparate fields, regulatory regimes reasonable for one kind of nanotechnology development may be inappropriately extended to others. There are a number of lessons to be gleaned from experience with the introduction of other technologies, which offer guidance with respect to what pitfalls to avoid and what issues to be sensitive to as we move forward with the development of nanotechnology applications. The problems encountered by nuclear power point out the dangers of over-promising and the role the need for the technology plays in ameliorating fears of risk. The public reaction to biomedical engineering and biotechnology highlights, in addition, the cultural factors that come into play when technologies raise questions about what is 'natural' and what is 'foreign' and what conceptions are involved in defining 'personhood'. In all cases, it has been clear that a main task for those introducing new technology is building public trust-in the safety of the technologies and the integrity of those introducing it. The advocates of nanotechnology have already shown that they are generally aware of the need to consider the public

  7. Responsible nanotechnology development

    Energy Technology Data Exchange (ETDEWEB)

    Forloni, Gianluigi, E-mail: forloni@marionegri.it [Istituto di Ricerche Farmacologiche ' Mario Negri' , Department of Neuroscience (Italy)

    2012-08-15

    Nanotechnologies have an increasing relevance in our life, numerous products already on the market are associated with this new technology. Although the chemical constituents of nanomaterials are often well known, the properties at the nano level are completely different from the bulk materials. Independently from the specific application the knowledge in this field involves different type of scientific competence. The accountability of the nanomaterial research imply the parallel development of innovative methodological approaches to assess and manage the risks associated to the exposure for humans and environmental to the nanomaterials for their entire life-cycle: production, application, use and waste discharge. The vast numbers of applications and the enormous amount of variables influencing the characteristics of the nanomaterials make particularly difficult the elaboration of appropriate nanotoxicological protocols. According to the official declarations exist an awareness of the public institutions in charge of the regulatory system, about the environmental, health and safety implications of nanotechnology, but the scientific information is insufficient to support appropriate mandatory rules. Public research programmers must play an important role in providing greater incentives and encouragement for nanotechnologies that support sustainable development to avoid endangering humanity's well being in the long-term. The existing imbalance in funds allocated to nanotech research needs to be corrected so that impact assessment and minimization and not only application come high in the agenda. Research funding should consider as a priority the elimination of knowledge gaps instead of promoting technological application only. With the creation of a public register collecting nanomaterials and new applications it is possible, starting from the information available, initiate a sustainable route, allowing the gradual development of a rational and informed

  8. Responsible nanotechnology development

    International Nuclear Information System (INIS)

    Nanotechnologies have an increasing relevance in our life, numerous products already on the market are associated with this new technology. Although the chemical constituents of nanomaterials are often well known, the properties at the nano level are completely different from the bulk materials. Independently from the specific application the knowledge in this field involves different type of scientific competence. The accountability of the nanomaterial research imply the parallel development of innovative methodological approaches to assess and manage the risks associated to the exposure for humans and environmental to the nanomaterials for their entire life-cycle: production, application, use and waste discharge. The vast numbers of applications and the enormous amount of variables influencing the characteristics of the nanomaterials make particularly difficult the elaboration of appropriate nanotoxicological protocols. According to the official declarations exist an awareness of the public institutions in charge of the regulatory system, about the environmental, health and safety implications of nanotechnology, but the scientific information is insufficient to support appropriate mandatory rules. Public research programmers must play an important role in providing greater incentives and encouragement for nanotechnologies that support sustainable development to avoid endangering humanity’s well being in the long-term. The existing imbalance in funds allocated to nanotech research needs to be corrected so that impact assessment and minimization and not only application come high in the agenda. Research funding should consider as a priority the elimination of knowledge gaps instead of promoting technological application only. With the creation of a public register collecting nanomaterials and new applications it is possible, starting from the information available, initiate a sustainable route, allowing the gradual development of a rational and informed approach

  9. Bioengineered riboflavin in nanotechnology.

    Science.gov (United States)

    Beztsinna, N; Solé, M; Taib, N; Bestel, I

    2016-02-01

    Riboflavin (RF) is an essential water-soluble vitamin with unique biological and physicochemical properties such as transporterspecific cell internalization, implication in redox reactions, fluorescence and photosensitizing. Due to these features RF attracted researchers in various fields from targeted drug delivery and tissue engineering to optoelectronics and biosensors. In this review we will give a brief reminder of RF chemistry, its optical, photosensitizing properties, RF transporter systems and its role in pathologies. We will point a special attention on the recent findings concerning RF applications in nanotechnologies such as RF functionalized nanoparticles, polymers, biomolecules, carbon nanotubes, hydrogels and implants for tissue engineering.

  10. Nanotechnology and human health

    CERN Document Server

    Malsch, Ineke

    2013-01-01

    Addressing medium- and long-term expectations for human health, this book reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while readers with a social science background will benefit from the discussion of realistic prospects of na

  11. Biomedical engineering and nanotechnology

    International Nuclear Information System (INIS)

    This book is predominantly a compilation of papers presented in the conference which is focused on the development in biomedical materials, biomedical devises and instrumentation, biomedical effects of electromagnetic radiation, electrotherapy, radiotherapy, biosensors, biotechnology, bioengineering, tissue engineering, clinical engineering and surgical planning, medical imaging, hospital system management, biomedical education, biomedical industry and society, bioinformatics, structured nanomaterial for biomedical application, nano-composites, nano-medicine, synthesis of nanomaterial, nano science and technology development. The papers presented herein contain the scientific substance to suffice the academic directivity of the researchers from the field of biomedicine, biomedical engineering, material science and nanotechnology. Papers relevant to INIS are indexed separately

  12. Bioengineered riboflavin in nanotechnology.

    Science.gov (United States)

    Beztsinna, N; Solé, M; Taib, N; Bestel, I

    2016-02-01

    Riboflavin (RF) is an essential water-soluble vitamin with unique biological and physicochemical properties such as transporterspecific cell internalization, implication in redox reactions, fluorescence and photosensitizing. Due to these features RF attracted researchers in various fields from targeted drug delivery and tissue engineering to optoelectronics and biosensors. In this review we will give a brief reminder of RF chemistry, its optical, photosensitizing properties, RF transporter systems and its role in pathologies. We will point a special attention on the recent findings concerning RF applications in nanotechnologies such as RF functionalized nanoparticles, polymers, biomolecules, carbon nanotubes, hydrogels and implants for tissue engineering. PMID:26708089

  13. Nanotechnology: The Incredible Invisible World

    Science.gov (United States)

    Roberts, Amanda S.

    2011-01-01

    The concept of nanotechnology was first introduced in 1959 by Richard Feynman at a meeting of the American Physical Society. Nanotechnology opens the door to an exciting new science/technology/engineering field. The possibilities for the uses of this technology should inspire the imagination to think big. Many are already pursuing such feats…

  14. Nanotechnology overview: Opportunities and challenges

    Science.gov (United States)

    Nanotechnology can be defined as the science of manipulating matter at the nanometer scale in order to discover new properties and possibly produce new products. For the past 30 years, a considerable amount of scientific interest and R&D funding devoted to nanotechnology has led to rapid developmen...

  15. How nanotechnology works in medicine

    OpenAIRE

    Arshpreet Kaur; Ms. Amandeep Kaur; Ms. Nitika Shahi

    2012-01-01

    Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. The National Nanotechnol...

  16. NANOTECHNOLOGY USE IN MEDICINE

    Directory of Open Access Journals (Sweden)

    Gopal Reddy

    2014-12-01

    Full Text Available Technology is shrinking quantity wise, increasing quality wise at a rather rapid rate. As a result, more and more advancements are taking place at the cellular, molecular and atomic level — at the nanoscale. NANOTECHNOLOGY: Is especially important to medicine because the medical field deals with things on the smallest of levels. Additionally, the small nano devices that are being developed right now can enter the body and treat and prevent diseases. NANOMEDICINE: Is the application of nanotechnology (the engineering of tiny machines for the prevention and treatment of disease in the human body. This evolving discipline has the potential to dramatically change medical science. NANOBOTS: Smallest of robots could be used to perform a number of functions inside the body and out. They could even be programmed to build other nanobots. NANOCOMPUTERS: To direct nanobots in their work, there are special computers. NANOTWEEZERS: devices are designed to manipulate nanostructures. Nanotweezers are usually constructed using nanotubes. NANOCHIP: Is an integrated circuit that is so small, in physical terms, that individual particles of matter play major roles

  17. Nanotechnologies in Latvia: Commercialisation Aspect

    Directory of Open Access Journals (Sweden)

    Geipele I.

    2014-12-01

    Full Text Available The authors consider the possibilities to apply the nanotechnology products of manufacturing industries in Latvia for further commercialisation. The purpose of the research is to find out the preliminary criteria for the system of engineering economic indicators for multifunctional nanocoating technologies. The article provides new findings and calculations for the local nanotechnology market research characterising the development of nanotechnology industry. The authors outline a scope of issues as to low activities rankings in Latvia on application of locally produced nanotechnologies towards efficiency of the resource use for nanocoating technologies. For the first time in Latvia, the authors make the case study research and summarise the latest performance indicators of the Latvian companies operating in the nanotechnology industry.

  18. Refining search terms for nanotechnology

    International Nuclear Information System (INIS)

    The ability to delineate the boundaries of an emerging technology is central to obtaining an understanding of the technology's research paths and commercialization prospects. Nowhere is this more relevant than in the case of nanotechnology (hereafter identified as 'nano') given its current rapid growth and multidisciplinary nature. (Under the rubric of nanotechnology, we also include nanoscience and nanoengineering.) Past efforts have utilized several strategies, including simple term search for the prefix nano, complex lexical and citation-based approaches, and bootstrapping techniques. This research introduces a modularized Boolean approach to defining nanotechnology which has been applied to several research and patenting databases. We explain our approach to downloading and cleaning data, and report initial results. Comparisons of this approach with other nanotechnology search formulations are presented. Implications for search strategy development and profiling of the nanotechnology field are discussed

  19. Nanotechnologies in Latvia: Commercialisation Aspect

    Science.gov (United States)

    Geipele, I.; Staube, T.; Ciemleja, G.; Ekmanis, J.; Zeltins, N.

    2014-12-01

    The authors consider the possibilities to apply the nanotechnology products of manufacturing industries in Latvia for further commercialisation. The purpose of the research is to find out the preliminary criteria for the system of engineering economic indicators for multifunctional nanocoating technologies. The article provides new findings and calculations for the local nanotechnology market research characterising the development of nanotechnology industry. The authors outline a scope of issues as to low activities rankings in Latvia on application of locally produced nanotechnologies towards efficiency of the resource use for nanocoating technologies. For the first time in Latvia, the authors make the case study research and summarise the latest performance indicators of the Latvian companies operating in the nanotechnology industry.

  20. EDITORIAL: Trends in Nanotechnology

    Science.gov (United States)

    Correia, Antonio; Serena, Pedro A.; Saenz, Juan Jose; Welland, Mark; Reifenberger, Ron

    2004-04-01

    With effect from August 2004 the journal Nanotechnology will discontinue the `Letters to the Editor' section. The increase in publication speed achieved for all articles now means that letters have no advantage. Fully electronic publication processes including electronic submission, refereeing and proofing, ensure that all papers are processed with minimum delay and are published as soon as they are ready. The journal will continue to publish high-quality original research papers, reviews and tutorials, as well as papers on the ethical and societal implications of nanotechnology at the discretion of the Editorial Board. All submitted papers will undergo a pre-selection procedure for suitability by the Editors of the journal. If a paper is accepted for consideration by the journal it will be sent to independent experts in the field for peer review. To speed up the publication process, we encourage authors to suggest five independent experts in their field as potential referees and supply their title, name, affiliation and e-mail address. The Editors of the journal may use these names at their discretion. Authors may also request that certain people are not to be used as referees. Papers of special interest will be given the utmost priority and on acceptance will be publicized further through worldwide press releases and reviews on the Institute of Physics website and on nanotechweb.org. As a service to authors and to the international physics community, and as part of our commitment to give authors' work as much visibility as possible, all papers are freely available online for 30 days from their electronic publication date. This means open access for citations to everyone in the world. We will also send an electronic offprint of your published paper to ten colleagues of your choice, giving your article an increased chance of being cited quickly. In the meantime, we are pleased to announce an increase in the Impact Factor of the journal in 2003 to 2.304, which means

  1. Nanotechnology-based drug delivery systems

    Directory of Open Access Journals (Sweden)

    Singh Baljit

    2007-12-01

    Full Text Available Abstract Nanoparticles hold tremendous potential as an effective drug delivery system. In this review we discussed recent developments in nanotechnology for drug delivery. To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. To achieve efficient drug delivery it is important to understand the interactions of nanomaterials with the biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signalling involved in pathobiology of the disease under consideration. Several anti-cancer drugs including paclitaxel, doxorubicin, 5-fluorouracil and dexamethasone have been successfully formulated using nanomaterials. Quantom dots, chitosan, Polylactic/glycolic acid (PLGA and PLGA-based nanoparticles have also been used for in vitro RNAi delivery. Brain cancer is one of the most difficult malignancies to detect and treat mainly because of the difficulty in getting imaging and therapeutic agents past the blood-brain barrier and into the brain. Anti-cancer drugs such as loperamide and doxorubicin bound to nanomaterials have been shown to cross the intact blood-brain barrier and released at therapeutic concentrations in the brain. The use of nanomaterials including peptide-based nanotubes to target the vascular endothelial growth factor (VEGF receptor and cell adhesion molecules like integrins, cadherins and selectins, is a new approach to control disease progression.

  2. Seasonal Influenza Questions & Answers

    Science.gov (United States)

    ... Medscape Podcasts Public Service Announcements (PSAs) Virus Images Influenza Types Seasonal Avian Swine Variant Pandemic Other Get ... Submit What's this? Submit Button Past Newsletters Seasonal Influenza, More Information Questions & Answers Language: English Español ...

  3. The Frontiers of Nanotechnology and Nanomedicine (SIG MED).

    Science.gov (United States)

    Lei, Polin P.

    2000-01-01

    This abstract of a planned session on the future of medicine explains the use of nanotechnology in medicine to manipulate biomolecules that regulate life and death processes and to help improve health care delivery. Topics include nanodevices for drug delivery, cancer detection and cure, and repairing genes. (LRW)

  4. Pharmacoresistant epilepsy and nanotechnology.

    Science.gov (United States)

    Rosillo-de la Torre, Argelia; Luna-Bárcenas, Gabriel; Orozco-Suárez, Sandra; Salgado-Ceballos, Hermelinda; García, Perla; Lazarowski, Alberto; Rocha, Luisa

    2014-06-01

    Epilepsy is one of the most common chronic neurological disorders. Furthermore, it is associated to diminished health-related quality of life and is thus considered a major public health problem. In spite of the large number of available and ongoing development of several new antiepileptic drugs (AEDs), a high percentage of patients with epilepsy (35-40%) are resistant to pharmacotherapy. A hypothesis to explain pharmacoresistance in epilepsy suggests that overexpression of multidrug resistance proteins, such as P-glycoprotein, on the endothelium of the blood brain barrier represents a challenge for effective AED delivery and concentration levels in the brain. Proven therapeutic strategies to control pharmacoresistant epilepsy include epilepsy surgery and neuromodulation. Unfortunately, not all patients are candidates for these therapies. Nanotechnology represents an attractive strategy to overcome the limited brain access of AEDs in patients with pharmacoresistant epilepsy. This manuscript presents a review of evidences supporting this idea.

  5. Nanotechnology applications in osteodistraction

    Directory of Open Access Journals (Sweden)

    Adam E Singleton

    2014-06-01

    Full Text Available Most current strategies for bone regeneration have relatively satisfactory results. However, there are drawbacks and limitations associated with their use and availability, and even controversial reports about their efficacy and cost-effectiveness. The induction of new bone formation through distraction osteogenesis (DO is widespread clinical application in the treatment of bone defects, limb deformities, and fracture nonunions. However, a lengthy period of external fixation is usually needed to allow the new bone to consolidate, and complications such as refracture at the distraction gap often occur. Although various biomaterials have been used as injectable delivery systems in DO models, little has been reported on the use of nanobiomaterials as carrier materials for the sustained release of growth factors in bone regeneration. One area of focus in nanotechnology is the delivery of osteogenic factors in an attempt to modulate the formation of bone. This review article seeks to demonstrate the potential of nanobiomaterials to improve biological applications pertinent to osteodistraction.

  6. Nanostructures and nanotechnology

    CERN Document Server

    Natelson, Douglas

    2015-01-01

    Focusing on the fundamental principles of nanoscience and nanotechnology, this carefully developed textbook will equip students with a deep understanding of the nanoscale. • Each new topic is introduced with a concise summary of the relevant physical principles, emphasising universal commonalities between seemingly disparate areas, and encouraging students to develop an intuitive understanding of this diverse area of study • Accessible introductions to condensed matter physics and materials systems provide students from a broad range of scientific disciplines with all the necessary background • Theoretical concepts are linked to real-world applications, allowing students to connect theory and practice • Chapters are packed with problems to help students develop and retain their understanding, as well as engaging colour illustrations, and are accompanied by suggestions for additional reading. Containing enough material for a one- or two-semester course, this is an excellent resource for senior undergra...

  7. Materials and nanotechnology

    International Nuclear Information System (INIS)

    The focus of the Materials and Nanotechnology Program is technology development related to processing, analysis, testing and characterization of materials in general. These are achieved through execution of R&D projects in engineering and materials science, cooperative projects with private and public sector companies, universities and other research institutes. Besides technology development, this Program also fosters training and human resource development in association with the University of São Paulo and many industrial sectors. This Program is divided into sub-programs in broad areas such as ceramic, composite and metallic materials as well as characterization of physical and chemical properties of materials. The sub-programs are further divided into general topics and within each topic, R&D projects. A brief description of progress in each topic during the last three years follows. (author)

  8. Nanoscience Nanotechnologies and Nanophysics

    CERN Document Server

    Dupas, Claire; Lahmani, Marcel

    2007-01-01

    Nanotechnologies and nanosciences are a fast-developing field of research, which sit at the point of convergence of several disciplines (physics, chemistry, biology, mechanics, etc.). This practically-oriented overview is designed to provide students and researchers with essential information on both the tools of manufacture and specific features of the nanometric scale, as well as applications within the most active fields (electronics, magnetism, information storage, biology). Specific applications and techniques covered include nanolithography, STM and AFM, nanowires and supramolecules, molecular electronics, optronics, and simulation. Each section of the book devotes considerable space to industrial applications and prospective developments. The carefully edited contributions are written by reserach workers and unirveisty instructors who are experts in their own fields and full up-to-date with the latest developments. Their uniform and self-contained nature permit users to access the most relevant chapter...

  9. Working with the NCL - Evaluation Criteria for Candidate Nanomaterials - Nanotechnology Characterization Laboratory

    Science.gov (United States)

    Nanostrategies proposed to the NCL for characterization will be ranked according to the measure of their projected impact on clinical cancer applications and/or furthering nanotechnology's compatibility with biological systems.

  10. NASA Applications of Molecular Nanotechnology

    Science.gov (United States)

    Globus, Al; Bailey, David; Han, Jie; Jaffe, Richard; Levit, Creon; Merkle, Ralph; Srivastava, Deepak

    1998-01-01

    Laboratories throughout the world are rapidly gaining atomically precise control over matter. As this control extends to an ever wider variety of materials, processes and devices, opportunities for applications relevant to NASA's missions will be created. This document surveys a number of future molecular nanotechnology capabilities of aerospace interest. Computer applications, launch vehicle improvements, and active materials appear to be of particular interest. We also list a number of applications for each of NASA's enterprises. If advanced molecular nanotechnology can be developed, almost all of NASA's endeavors will be radically improved. In particular, a sufficiently advanced molecular nanotechnology can arguably bring large scale space colonization within our grasp.

  11. Current situation and industrialization of Taiwan nanotechnology

    International Nuclear Information System (INIS)

    Nanotechnology is projected to be a very promising field, and the impact of nanotechnology on society is increasingly significant as the research funding and manufactured goods increase exponentially. A clearer picture of Taiwan's current and future nanotechnology industry is an essential component for future planning. Therefore, this investigation studies the progress of industrializing nanotechnology in Taiwan by surveying 150 companies. Along with understanding Taiwan's current nanotechnology industrialization, this paper also suggests ways to promote Taiwan's nanotechnology. The survey results are summarized and serve as the basis for planning a nanotechnology industrialization strategy

  12. PREFACE: Rusnanotech 2010 International Forum on Nanotechnology

    Science.gov (United States)

    Kazaryan, Konstantin

    2011-03-01

    Deputy Director, Institute of Semiconductor Physics, Siberian Branch of Russian Academy of Sciences, RussiaProf Vladimir Kvardakov, Corresponding Member of Russian Academy of SciencesExecutive Director, Kurchatov Center of Synchrotron Radiation and Nanotechnology, RussiaProf Edward Son, Corresponding member of Russian Academy of SciencesScientific Deputy Director, Joint Institute for High Temperatures, Russian Academy of Sciences, RussiaProf Andrey GudkovSenior Vice President, Basic Science Chairman, Department of Cell Stress Biology, Roswell Park Cancer Institute, USAProf Robert NemanichChair, Department of Physics, Arizona State University, USAProf Kandlikar SatishProfessor, Rochester Institute of Technology, USAProf Xiang ZhangUC Berkeley, Director of NSF Nano-scale Science and Engineering Center (NSEC), USAProf Andrei ZvyaginProfessor, Macquarie University, AustraliaProf Sergey KalyuzhnyDirector of the Scientific and Technological Expertise Department, RUSNANO, RussiaKonstantin Kazaryan, PhDExpert of the Scientific and Technological Expertise Department, RUSNANO, Russia, Program Committee SecretarySimeon ZhavoronkovHead of Nanotechnology Programs Development Office, Rusnanotech Forum Fund for the Nanotechnology Development, Russia Editors of the proceedings: Section "Nanoelectronics" - Corresponding Member of Russian Academy of Sciences, Professor Anatoly Dvurechenskii (Institute of Semiconductor Physics, RAS).Section "Nanophotonics" - Professor Vasily Klimov (Institute of Physics, RAS).Section "Nanodiagnostics" - Professor P Kashkarov (Russian Scientific Center, Kurchatov Institute).Section "Nanotechnology for power engineering" - Corresponding Member of Russian Academy of Sciences, Professor Eduard Son (Joint Institute for High Temperatures, RAS).Section "Catalysis and chemical industry" - Member of Russian Academy of Sciences, Professor Valentin Parmon (Institute of Catalysis SB RAS).Section "Nanomaterials" - E Obraztsova, PhD (Institute of Physics, RAS), Marat Gallamov Ph

  13. (Updated) Nanotechnology: Understanding the Tiny Particles That May Save a Life | Poster

    Science.gov (United States)

    By Nathalie Walker, Guest Writer Could nanotechnology—the study of tiny matter ranging in size from 1 to 200 nanometers—be the future of cancer treatment? Although it is a relatively new field in cancer research, nanotechnology is not new to everyday life. Have you ever thought about the tennis ball you’ve thrown with your dog at the park and wondered what it is made of? Nanotechnology is used to make the tennis ball stronger.

  14. EDITORIAL: Nanotechnology in vivo Nanotechnology in vivo

    Science.gov (United States)

    Demming, Anna

    2010-04-01

    Since the development of x-rays the ability to image inside our bodies has provided medicine with a potent diagnostic tool, as well as fascinating us with the eerie evidence of our mechanistic mortality. In December 2008 Osamu Shimomura, Martin Chalfie and Roger Y Tsien received a Nobel Prize for the discovery and development of the green fluorescent protein. The award recognised a new discovery that further facilitated our abilities to follow cellular activities and delve deeper into the workings of living organisms. Since the first observation of green fluorescent protein in jelly fish over thirty years ago, quantum dots have emerged as a potential alternative tool for imaging [1]. The advantages of quantum dots over organic dyes and fluorescent proteins include intense luminescence, high molar extinction coefficient, resistance to photobleaching, and broad excitation with narrow emission bands. However, one drawback for biological applications has been the layer of hydrophobic organic ligands often present at the surface as a result of the synthesis procedures. One solution to improve the solubility of quantum dots has been to conjugate them with a hydrophilic substance, as reported by Nie et al [2]. Chitosan is a hydrophilic, non-toxic, biocompatible and biodegradable substance and has been conjugated with quantum dots such as CdSe-ZnS [2] for bioassays and intracellular labelling. As well as luminescence, different nanoparticles present a variety of exceptional properties that render them useful in a range of bio applications, including MRI, drug delivery and cancer hyperthermia therapy. The ability to harness these various attributes in one system was reported by researchers in China, who incorporated magnetic nanoparticles, fluorescent quantum dots and pharmaceutical drugs into chitosan nanoparticles for multifunctional smart drug delivery systems [3]. More recently silicon quantum dots have emerged as a less cytotoxic alternative to CdSe for bio

  15. Think small: nanotechnology for plastic surgeons.

    Science.gov (United States)

    Nasir, Amir R; Brenner, Sara A

    2012-11-01

    The purpose of this article is to introduce the topic of nanotechnology to plastic surgeons and to discuss its relevance to medicine in general and plastic surgery in particular. Nanotechnology will be defined, and some important historical milestones discussed. Common applications of nanotechnology in various medical and surgical subspecialties will be reviewed. Future applications of nanotechnology to plastic surgery will be examined. Finally, the critical field of nanotoxicology and the safe use of nanotechnology in medicine and plastic surgery will be addressed.

  16. Technology Transfer: The Case of Nanotechnology

    OpenAIRE

    Lewin, Peter Marius Etienne

    2014-01-01

    The thesis provides an in-depth discussion of technology transfer of innovations utilizing nanotechnology. Innovations that use nanotechnology as a component are controversial among governments, international organizations, NGOs, laypeople and the multinational corporation. Commercial barriers linked to nanotechnology include market acceptance and very high development costs. Nanotechnology start-ups may differ from established firms with respect to commercial strategy. Nanotechnology start-u...

  17. Nanoethics: Ethics For, From, or With Nanotechnologies?

    OpenAIRE

    Vanessa Nurock

    2010-01-01

    The concern for ethics is a leitmotiv when dealing with nanotechnologies. However, the target of this concern is far from being obvious, and the word 'nanoethics' itself has no clear-cut definition. Indeed, nanoethics is usually said to be 'the ethics of nanotechnologies', but it is never specified whether this 'ethics of nanotechnologies' is 'an ethics for nanotechnologies' or 'an ethics from nanotechnologies'. This paper aims to show that these two characterizations of nanoethics (for/from)...

  18. How nanotechnology works in medicine

    Directory of Open Access Journals (Sweden)

    Arshpreet Kaur

    2012-09-01

    Full Text Available Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials. Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging. At present international hospitals are working on projects to develop new medical devices with the help of nanotechnology to better serve the world. Neuro-electronic interfaces and other nanoelectronics-based sensors are another active goal of research. Nanosensors are used mainly include various medicinal purposes and as gateways to building other nanoproducts, such as computer chips that work at the nanoscale and nanorobots

  19. The challenges of green nanotechnology

    Directory of Open Access Journals (Sweden)

    Miguel de la Guardia

    2014-03-01

    Full Text Available Nanomaterials have great impacts on life sciences; however,these advanced materials may induce inadvertant consequences.Thus, this editorial will highlight the futuristic challenges in green nanotechnology.

  20. NANOTECHNOLOGY: A BOON OR BANE

    Directory of Open Access Journals (Sweden)

    Priyanka Singh

    2011-12-01

    Full Text Available Nanotechnology deals with the physical and chemical attributes of molecular scale structures, and they can be combined to form larger structures for human use. Because of this dimensional range, nanoparticles and structure get some unusual and novel properties. Nanotechnology deals with the study and analysis of these properties also. Indeed it is an emerging area of applied science and technology whose theme is the control of matter on the atomic and molecular scale generally 100nm or smaller. The impact of nanotechnology is expanding and nothing will remain untouched. Applications are enormous and limitless. Nanotechnology enables doing things better than in the conventional technology viz.•Economic development•Improving food security•Health Diagnosis, Monitoring and Scanning•Safe Drinking Water•Environmental pollution•Agriculture•Energy Storage, Production and ConservationAs a coin has two sides, nanotechnology also has a flip side. No doubt, nanotechnology will be incorporated into every facet of our lives, making things easier, faster and longer lasting. Potential dangers of technology that are being discussed in various forms includes•Possible increased inflammatory response in the body due to small size•Potential terrorist use•Social disruption from new products/ lifestyles•Risks of a “Grey Goo” (hypothetical end of the worldNow there is a critical need to fund researchers and engineers across disciplines and institutional boundaries in order to advance in the arena of nanotechnologies. There must be innovative partnerships that integrate research and education, accelerate applications and fully explore the implications of nanotechnology on our health, wealth and lives.

  1. Food nanotechnology – an overview

    OpenAIRE

    Bhupinder S Sekhon

    2010-01-01

    Bhupinder S SekhonInstitute of Pharmacy and Department of Biotechnology, Punjab College of Technical Education, Jhande, Ludhiana, IndiaAbstract: Food nanotechnology is an area of emerging interest and opens up a whole universe of new possibilities for the food industry. The basic categories of nanotechnology applications and functionalities currently in the development of food packaging include: the improvement of plastic materials barriers, the incorporation of active components that can del...

  2. Food nanotechnology – an overview

    OpenAIRE

    Bhupinder S Sekhon

    2010-01-01

    Food nanotechnology is an area of emerging interest and opens up a whole universe of new possibilities for the food industry. The basic categories of nanotechnology applications and functionalities currently in the development of food packaging include: the improvement of plastic materials barriers, the incorporation of active components that can deliver functional attributes beyond those of conventional active packaging, and the sensing and signaling of relevant information. Nano food packag...

  3. Global Governmental Investment in Nanotechnologies

    OpenAIRE

    Jia, Lee

    2005-01-01

    Nanotechnologies seem to have huge potential to bring benefits in areas as diverse as drug development, water decontamination, information and communication infrastructures, and the production of stronger, lighter and perfect nanomaterials. This potential attracts global investment from governments and private sectors in nanotechnologies with the hopes that R&D and commercial applications of nanomaterials, nanodevices, nanoparticles and nanodrugs will provide new impetus, after the ebb-tides ...

  4. CAT questions and answers

    International Nuclear Information System (INIS)

    This document, prepared in February 1993, addresses the most common questions asked by APS Collaborative Access Teams (CATs). The answers represent the best judgment on the part of the APS at this time. In some cases, details are provided in separate documents to be supplied by the APS. Some of the answers are brief because details are not yet available. The questions are separated into five categories representing different aspects of CAT interactions with the APS: (1) Memorandum of Understanding (MOU), (2) CAT Beamline Review and Construction, (3) CAT Beamline Safety, (4) CAT Beamline Operations, and (5) Miscellaneous. The APS plans to generate similar documents as needed to both address new questions and clarify answers to present questions

  5. Information Quality on Yahoo! Answers

    OpenAIRE

    Fichman, Pnina

    2013-01-01

    Along with the proliferation of the social web, question and answer (QA) sites attract millions of users around the globe. On these sites, users ask questions while others provide answers. These QA sites vary by their scope, size, and quality of answers; the most popular QA site is Yahoo! Answers. This chapter aims to examine the quality of information produced by the crowd on Yahoo! Answers, assuming that given enough eyeballs all questions can get good answers. Findings illustrate a process...

  6. Mathematics year 5 answers

    CERN Document Server

    Alexander, Serena; Poggo, Tammy

    2014-01-01

    Features the complete set of answers to the exercises in Mathematics Year 5, to save you time marking work and enable you to identify areas requiring further attention. The book includes diagrams and workings where necessary, to ensure pupils understand how to present their answers. Also available from Galore Park www.galorepark.co.uk :. - Mathematics Year 5. - Mathematics Year 6. - 11+ Maths Practice Exercises. - 11+ Maths Revision Guide. - 10-Minute Maths Tests Workbook Age 8-10. - 10-Minute Maths Tests Workbook Age 9-11. - Mental Arithmetic Workbook Age 8-10. - Mental Arithmetic Workbook Ag

  7. Nanotechnology and medicine ? The upside and the downside

    Directory of Open Access Journals (Sweden)

    Kwatra Shubhika

    2013-03-01

    Full Text Available Nanotechnology is the use of technology at the nano (10-9 level. Nanoscale devices differ from the conventional methods of diagnosing and treating diseases, and present certain advantages over them. Nanomedicine is a branch of the newly emerging field of nanotechnology. It is a rapidly developing discipline. By gaining access to many areas of the body which were thought to be unreachable, the nano devices possess the potential to not only detect diseases but also deliver treatment in ways unimagined before. The various nano devices used are nanowires, cantilevers, nanoparticles, nanoshells, dendrimers, fullerenes, micelles and vesicles. Nanotechnology can even be used in the future to treat lifethreatening diseases like cancer. However, it does have some drawbacks, for example, toxicity, environmental harm and organ damage caused by nanoparticles. There are some ethical issues concerned with the use of nanotechnology too. The purpose of the article is to discuss briefly both sides of the field of nanomedicine: to study the applications of nanotechnology in medicine and, also, to discuss its limitations.

  8. Nanotechnologies and global survival

    Directory of Open Access Journals (Sweden)

    Mitrović Veselin

    2012-01-01

    Full Text Available The rapid development of science and technology from the mid-20th century, on one hand, and increasing world population as well as decreasing of natural resources on the other has raised the risk of escalating social conflicts. Regarding this facts, it is inevitable to admit that the future of mankind lies in acceptable moral and social implementation of this technologies. Having that in mind, many questions have been generated about responsible applications of nanotechnologies: about the positive and negative effects of their usage, about patterns of their socio-spatial distribution both at global and national level, about economic development of states who use those technologies, and their possible effect of individual health and biosphere preservation. Regarding those questions, it is necessary to use knowledge of nature science as well as knowledge of philosophy, sociology, etc., in order to analyze the level of development and life conditions in human communities and differentiate between “mere”, “miserable”, “idealistic“, “irresponsible“ and “acceptable“ survival. Starting from sociological context and following Potter’s concepts, this article argues for the concept of consurvivality that is durable, acceptable, sustainable, realistic and global.

  9. Transportation questions and answers

    International Nuclear Information System (INIS)

    This document summarizes the transport and handling of radioactive materials in a ''question'' and ''answer'' form. It explains what is radioactive material, how it is shipped, and in case there is a spill, who is responsible for it. It also provides safeguard measures for radioactive materials. (TC)

  10. Are classical process safety concepts relevant to nanotechnology applications?

    International Nuclear Information System (INIS)

    The answer to the question posed by the title of this paper is yes - with adaptation to the specific hazards and challenges found in the field of nanotechnology. The validity of this affirmative response is demonstrated by relating key process safety concepts to various aspects of the nanotechnology industry in which these concepts are either already practised or could be further applied. This is accomplished by drawing on the current author's experience in process safety practice and education as well as a review of the relevant literature on the safety of nanomaterials and their production. The process safety concepts selected for analysis include: (i) risk management, (ii) inherently safer design, (iii) human error and human factors, (iv) safety management systems, and (v) safety culture.

  11. NANOTECHNOLOGY IN TEXTILE INDUSTRY [REVIEW

    Directory of Open Access Journals (Sweden)

    RATIU Mariana

    2015-05-01

    Full Text Available Nanoscience and nanotechnology are the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering. Nanotechnology overcomes the limitation of applying conventional methods to impart certain properties to textile materials. There is no doubt that in the next few years nanotechnology will penetrate into every area of the textile industry. Nanotextiles are nanoscale fibrous materials that can be fictionalized with a vast array of novel properties, including antibiotic activity, self-cleaning and the ability to increase reaction rates by providing large surface areas to potential reactants. These materials are used not only as cloth fabric, but as filter materials, wound-healing gauzes and antibacterial food packaging agents in food industry. World demand for nano-materials will rise more than two-and-a-half times to $5.5 billion in 2016 driven by a combination of increased market penetration of existing materials, and ongoing development of new materials and applications. In recent years was demonstrated that nanotechnology can be used to enhance textile attributes, such as fabric softness, durability and breathability, water repellency, fire retardancy, antimicrobial properties in fibers, yarns and fabrics. The development of smart nanotextiles has the potential to revolutionize the production of fibers, fabrics or nonwovens and functionality of our clothing and all types of textile products and applications. Nanotechnology is considered one of the most promising technologies for the 21st century. Today is said that if the IT is the wave of the present, the nanotechnology is the wave of the present, the nanotechnology is the wave of the future.

  12. 纳米技术在胃癌诊断和治疗中的应用%Application of nanotechnology in the diagnosis and treatment of gastric cancer

    Institute of Scientific and Technical Information of China (English)

    王国斌

    2010-01-01

    @@ 纳米技术研究结构尺寸为0.1~100 nm范围内的材料的组成、性质和特殊功能.在这个范围的微粒具有高反应性、高表面积、高扩散性、奇特磁性和强荧光效应等,并且其光学、电学和磁性等特性均可调控[1-2].直径<50 nm的微粒很容易进入大部分细胞内,<20 nm的微粒能穿过血管壁进入组织间隙.磁性纳米微粒与肿瘤特异的抗体结合可构成肿瘤特异性对比剂.%Gastric cancer is the leading cause of cancer mortality. The determination of early diagnosis and treatment of gastric cancer is an important issue for medical researchers.Although there are many methods to help clinicians detect gastric cancer, the early diagnosis rate is still unsatisfactory. As a newlydeveloped field, nanomedicine provides the potential for the diagnosis and treatment of gastric cancer. Nanomaterials have functional and structural properties that are not available from either discrete or bulk materials. Nanoparticles can be modified to target cancer cells, and when carrying fluorescent agents,they can delineate the focus clearly. Nanoparticles can also kill tumor cells without injuring normal cells when they serve as the drug loader. Fluorescent nanoparticles can also guide surgeons to resect lesions completely and clear the metastatic lymph nodes completely.

  13. German innovation initiative for nanotechnology

    International Nuclear Information System (INIS)

    In many areas of nanotechnology, Germany can count on a good knowledge basis due to its diverse activities in nanosciences. This knowledge basis, when paired with the production and sales structures needed for implementation and the internationally renowned German talent for system integration, should consequently lead to success in the marketplace. And this is exactly the field of application for the innovation initiative 'Nanotechnologie erobert Maerkte' (nanotechnology conquers markets) and for the new BMBF strategy in support of nanotechnology. Until now, aspects of nanotechnology have been advanced within the confines of their respective technical subject areas. However, the primary aim of incorporating them into an overall national strategy is to build on Germany's well-developed and internationally competitive research in science and technology to tap the potential of Germany's important industrial sectors for the application of nanotechnology through joint research projects (leading-edge innovations) that strategically target the value-added chain. This development is to be supported by government education policy to remedy a threatening shortage of skilled professionals. To realize that goal, forward-looking political policymaking must become oriented to a uniform concept of innovation, one that takes into consideration all facets of new technological advances that can contribute to a new culture of innovation in Germany. And that includes education and research policy as well as a climate that encourages and supports innovation in science, business and society

  14. International strategy for Nanotechnology Research

    International Nuclear Information System (INIS)

    The worldwide nanotechnology research and development (R and D) investment reported by government organizations has increased by a factor of 3.5 between 1997 and 2001, and the highest rate of 90% is in 2001. At least 30 countries have initiated or are beginning national activities in this field. Scientists have opened a broad net of discoveries that does not leave any major research area untouched in physical, biological, and engineering sciences. Industry has gained confidence that nanotechnology will bring competitive advantages. The worldwide annual industrial production is estimated to exceed $1 trillion in 10-15 years from now, which would require about 2 million nanotechnology workers. U.S. has initiated a multidisciplinary strategy for development of science and engineering fundamentals through the National Nanotechnology Initiative. Japan and Europe have broad programs, and their current plans look ahead to four to five years. Other countries have encouraged their own areas of strength, several of them focusing on fields of the potential markets. Differences among countries are observed in the research domain they are aiming for, the level of program integration into various industrial sectors, and in the time scale of their R and D targets. Nanotechnology is growing in an environment where international interactions accelerate in science, education and industrial R and D. A global strategy of mutual interest is envisioned by connecting individual programs of contributing countries, professional communities, and international organizations

  15. Flexible Query Answering Systems

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 10th International Conference on Flexible Query Answering Systems, FQAS 2013, held in Granada, Spain, in September 2013. The 59 full papers included in this volume were carefully reviewed and selected from numerous submissions. The papers...... are organized in a general session train and a parallel special session track. The general session train covers the following topics: querying-answering systems; semantic technology; patterns and classification; personalization and recommender systems; searching and ranking; and Web and human......-computer interaction. The special track covers some some specific and, typically, newer fields, namely: environmental scanning for strategic early warning; generating linguistic descriptions of data; advances in fuzzy querying and fuzzy databases: theory and applications; fusion and ensemble techniques for on-line...

  16. Campylobacter Questions and Answers

    Science.gov (United States)

    ... Forms Skip Navigation Z7_0Q0619C0JGR010IFST1G5B10H1 Web Content Viewer (JSR 286) Actions ${title} Loading... / Topics / Food Safety Education / ... Q and Answers Z7_0Q0619C0JGR010IFST1G5B10H3 Web Content Viewer (JSR 286) Actions ${title} Loading... Z7_0Q0619C0JGR010IFST1G5B1090 Web Content ...

  17. Competition: the answers

    CERN Multimedia

    Staff Association

    2016-01-01

    The correct answers to the Staff Association Competition are: How many women delegates are there currently in the Staff Council? -14 Who is the current President of the Staff Association? - Alessandro Raimondo Which year was the Nursery School established by the Staff Association at CERN?  -1965 How many CERN clubs are supported by the Staff Association? -44 What is the supreme representative body of the Staff Association ? -The Staff Council   The winners will be informed by email.

  18. Nanotechnology: Role in dental biofilms

    Directory of Open Access Journals (Sweden)

    Bhardwaj Sonia

    2009-01-01

    Full Text Available Biofilms are surface- adherent populations of microorganisms consisting of cells, water and extracellular matrix material Nanotechnology is promising field of science which can guide our understanding of the role of interspecies interaction in the development of biofilm. Streptococcus mutans with other species of bacteria has been known to form dental biofilm. The correlation between genetically modified bacteria Streptococcus mutans and nanoscale morphology has been assessed using AFMi.e atomic force microscopy. Nanotechnology application includes 16 O/ 18 O reverse proteolytic labeling,use of quantum dots for labeling of bacterial cells, selective removal of cariogenic bacteria while preserving the normal oral flora and silver antimicrobial nanotechnology against pathogens associated with biofilms. The future comprises a mouthwash full of smart nanomachines which can allow the harmless flora of mouth to flourish in a healthy ecosystem

  19. Scope of nanotechnology in modern textiles

    Science.gov (United States)

    This review article demonstrates the scope and applications of nanotechnology towards modification and development of advanced textile fibers, yarns and fabrics and their processing techniques. Basically, it summarizes the recent advances made in nanotechnology and its applications to cotton textil...

  20. Nanotechnology in medicine emerging applications

    CERN Document Server

    Koprowski, Gene

    2012-01-01

    This book will describe some of the most recent breakthroughs and promising developments in the search for improved diagnostics and therapies at the very small scales of living biological systems. While still very much a technology in the research and development stage, nanotechnology is already transforming today's medicine. This book, written by a general science author, provides a general overview of medical treatment potentials of nanotechnology in new, more effective drug delivery systems, in less invasive, ultra-small scale medical tools, and in new materials that can mimic or enhance na

  1. DNA nanotechnology and fluorescence applications.

    Science.gov (United States)

    Schlichthaerle, Thomas; Strauss, Maximilian T; Schueder, Florian; Woehrstein, Johannes B; Jungmann, Ralf

    2016-06-01

    Structural DNA nanotechnology allow researchers to use the unique molecular recognition properties of DNA strands to construct nanoscale objects with almost arbitrary complexity in two and three dimensions. Abstracted as molecular breadboards, DNA nanostructures enable nanometer-precise placement of guest molecules such as proteins, fluorophores, or nanoparticles. These assemblies can be used to study biological phenomena with unprecedented control over number, spacing, and molecular identity. Here, we give a general introduction to structural DNA nanotechnology and more specifically discuss applications of DNA nanostructures in the field of fluorescence and plasmonics. PMID:26773303

  2. MULTIMODAL EVALUATIONS OF JAPAN'S NANOTECHNOLOGY COMPETITIVENESS

    OpenAIRE

    DAISUKE KANAMA

    2013-01-01

    In Japan, there are great expectations for nanotechnology because it is expected not only to renovate existing markets but also create new, large, and wide-ranging markets. Japan is generally believed to be strong in nanotechnology. However, how should the competitiveness of nanotechnology be measured?Based on publications, patents, venture business, and other survey results, this paper intends to discuss Japan's nanotechnology competitiveness and changes in the competition areas of nanotechn...

  3. Nanotechnology in dentistry: Current achievements and prospects

    OpenAIRE

    Ramandeep Singh Gambhir; G M Sogi; Ashutosh Nirola; Rajdeep Brar; Tegbir Sekhon; Heena Kakar

    2013-01-01

    Nanotechnology offers advances particularly in each and every field of human activity such as electronics, industry, telecommunications, environmental science, etc., The field of nanotechnology has got remarkable potential that can bring considerable improvements to the human health, enhanced use of natural resources, and reduced environmental pollution. Since 1990s, nanotechnology has been exploited for potential medical and dental applications. Nanotechnology holds promise for advanced diag...

  4. DEVELOPMENT OF NANOTECHNOLOGY: BLESSING OR A DANGER?

    OpenAIRE

    Yakovlev Anatoly Romanovich

    2012-01-01

    The paper deals with the negative aspects of nanotechnology development on the global and national scales. Possible economic, environmental and social risks and latent threats to the formation of nanoindustry and nanoproducts consumption are discussed. Based on the analysis of foreign and Russian researchers is made SWOT-analysis of nanotechnology, in which all the key features development of nanotechnology. Under article attempts to analyze the basic regulations in the field of nanotechnolog...

  5. General Account Of Nanotechnology and Nano Toxicology

    OpenAIRE

    Dr. K.B.Koteshwara

    2015-01-01

    Nanotechnology represents revolutionary changes in 21st century with its continuous advancements and progression with time and in knowledge. It has applications in each and every fields of science leaving any aspects untouched. Nanotechnology also embraces many advantages in medicines, diagnostics and drug delivery, thus can be termed as pharmaceutical nanotechnology. Whether, its established drug or new entity, from improving solubility to specific organ targeting, nanotechnology is a platfo...

  6. Overview of Nanotechnology in Road Engineering

    OpenAIRE

    Arpit Singh; Dr. Sangita; Arpan Singh

    2015-01-01

    Nanotechnology has changed our vision, expectations, and abilities to control the material world. This paper examines and document applicable nanotechnology based product that can be improve the overall competitiveness of the Road engineering industry. In this review, nanotechnology is applying in road sector.

  7. Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art.

    Science.gov (United States)

    Ahmad, Mohammad Zaki; Alkahtani, Saad Ahmed; Akhter, Sohail; Ahmad, Farhan Jalees; Ahmad, Javed; Akhtar, Mohammad Shabib; Mohsin, Nehal; Abdel-Wahab, Basel A

    2016-01-01

    Comprehensive pharmacological screening of curcumin (CUR) has given the evidence that it is an excellent naturally occurring therapeutic moiety for cancer. It is very well tolerated with insignificant toxicity even after high doses of oral administration. Irrespective of its better quality as an anticancer agent, therapeutic application of CUR is hampered by its extremely low-aqueous solubility and poor bioavailability, rapid clearance and low-cellular uptake. A simple means of breaking up the restrictive factor of CUR is to perk-up its aqueous solubility, improve its bioavailability, protect it from degradation, and metabolism and potentiate its targeting capacity towards the cancer cell. The development in the field of nanomedicine has made excellent progresses toward enhancing the bioavailability of lipophilic drugs like CUR. Nanoparticles (NPs) are capable to deliver the CUR at specific area and thereby prevent it from physiological degradation and systemic clearance. In recent year, an assortment of nanomedicine-based novel drug delivery system has been designed to potentiate the bioavailability of CUR towards anticancer therapy. In this review, we discuss the recent development in the field of nanoCUR (NanoCur), including polymeric micelles, liposome, polymeric NPs, nanoemulsion, nanosuspension, solid lipid NPs (SLNPs), polymer conjugates, nanogel, etc. in anticancer application. PMID:26066739

  8. Nanotechnology for the developing world

    Energy Technology Data Exchange (ETDEWEB)

    El Naschie, M. Saladin [Department of Physics, University of Alexandria (Egypt); Department of Astrophysics, Cairo University (Egypt); Department of Physics, Mansura University (Egypt)

    2006-11-15

    The letter discusses the indispensable importance of Nanotechnology for the scientific and economical revival of the developing world. Similar to the nuclear age, and maybe far more so, the nanoage will be something of a Hemingway line of demarcation between the have and the have nots.

  9. Soft nanotechnology: "structure" vs. "function".

    Science.gov (United States)

    Whitesides, George M; Lipomi, Darren J

    2009-01-01

    This paper offers a perspective on "soft nanotechnology"; that is, the branch of nanotechnology concerned with the synthesis and properties of organic and organometallic nanostructures, and with nanofabrication using techniques in which soft components play key roles. It begins with a brief history of soft nanotechnology. This history has followed a path involving a gradual shift from the promise of revolutionary electronics, nanorobotics, and other futuristic concepts, to the realization of evolutionary improvements in the technology for current challenges in information technology, medicine, and sustainability. Soft nanoscience is an area that is occupied principally by chemists, and is in many ways indistinguishable from "nanochemistry". The paper identifies the natural tendency of its practitioners--exemplified by the speakers at this Faraday Discussion--to focus on synthesis and structure, rather than on function and application, of nanostructures. Soft nanotechnology has the potential to apply to a wide variety of large-scale applied (information technology, healthcare cost reduction, sustainability, energy) and fundamental (molecular biochemistry, cell biology, charge transport in organic matter) problems.

  10. Food Nanotechnology - Food Packaging Applications

    Science.gov (United States)

    Astonishing growth in the market for nanofoods is predicted in the future, from the current market of $2.6 billion to $20.4 billion in 2010. The market for nanotechnology in food packaging alone is expected to reach $360 million in 2008. In large part, the impetus for this predicted growth is the ...

  11. Food Nanotechnology: Food Packaging Applications

    Science.gov (United States)

    Astonishing growth in the market for nanofoods is predicted in the future, from the current market of $2.6 billion to $20.4 billion in 2010. The market for nanotechnology in food packaging alone is expected to reach $360 million in 2008. In large part the impetus for this predicted growth is the e...

  12. Applications of nanotechnology in biomedicine

    Directory of Open Access Journals (Sweden)

    Andreia Chirilă

    2014-06-01

    Full Text Available Nanobiotechnology is a new field in research, constituting the interface between the life sciences and nanotechnology. In this field, the size of the working range is between 1 nm and 100 nm. This new domain it proposes the exploitation of quality biomolecules and processes involved in the development of materials or devices with definite activity in medicine. Therapeutic nanotechnology seeks to provide specific features that can reduce morbidity and mortality in humans and animals, of which the most important are: a minimal invasive therapy, high density functions and the concentration in very small volumes. The first origins of the concept of nano-medicine are from Feynman's, who had the visionary idea of the nanorobots and similar mechanisms that could be designed, constructed, and placed in the body to perform cellular repairs at the molecular level. With the priorities crystallization in the medicine domain of XX and especially of the XXI’s century, also nanomedicine gained the momentum. In this respect the review proposes to introduce the reader to this fascinating field. There are provided information about cancer’s nanotherapy, examples of systems, applications of DNA, magnetic separation and manipulation of cells and biomolecules, nanotechnology applications in tissue engineering and many more. Also there are presented applications of nanotechnology in tissue engineering and about nano-robots.

  13. Broader Societal Issues of Nanotechnology

    International Nuclear Information System (INIS)

    Nanoscale science and engineering are providing unprecedented understanding and control over the basic building blocks of matter, leading to increased coherence in knowledge, technology, and education. The main reason for developing nanotechnology is to advance broad societal goals such as improved comprehension of nature, increased productivity, better healthcare, and extending the limits of sustainable development and of human potential. This paper outlines societal implication activities in nanotechnology R and D programs. The US National Nanotechnology Initiative annual investment in research with educational and societal implications is estimated at about $30 million (of which National Science Foundation (NSF) awards about $23 million including contributions to student fellowships), and in nanoscale research with relevance to environment at about $50 million (of which NSF awards about $30 million and EPA about $6 million). An appeal is made to researchers and funding organizations worldwide to take timely and responsible advantage of the new technology for economic and sustainable development, to initiate societal implications studies from the beginning of the nanotechnology programs, and to communicate effectively the goals and potential risks with research users and the public

  14. EDITORIAL: Quantum phenomena in Nanotechnology Quantum phenomena in Nanotechnology

    Science.gov (United States)

    Loss, Daniel

    2009-10-01

    Twenty years ago the Institute of Physics launched the journal Nanotechnology from its publishing house based in the home town of Paul Dirac, a legendary figure in the development of quantum mechanics at the turn of the last century. At the beginning of the 20th century, the adoption of quantum mechanical descriptions of events transformed the existing deterministic world view. But in many ways it also revolutionised the progress of research itself. For the first time since the 17th century when Francis Bacon established inductive reasoning as the means of advancing science from fact to axiom to law, theory was progressing ahead of experiments instead of providing explanations for observations that had already been made. Dirac's postulation of antimatter through purely theoretical investigation before its observation is the archetypal example of theory leading the way for experiment. The progress of nanotechnology and the development of tools and techniques that enabled the investigation of systems at the nanoscale brought with them many fascinating observations of phenomena that could only be explained through quantum mechanics, first theoretically deduced decades previously. At the nanoscale, quantum confinement effects dominate the electrical and optical properties of systems. They also render new opportunities for manipulating the response of systems. For example, a better understanding of these systems has enabled the rapid development of quantum dots with precisely determined properties, which can be exploited in a range of applications from medical imaging and photovoltaic solar cells to quantum computation, a radically new information technology being currently developed in many labs worldwide. As the first ever academic journal in nanotechnology, {\\it Nanotechnology} has been the forum for papers detailing progress of the science through extremely exciting times. In the early years of the journal, the investigation of electron spin led to the formulation

  15. Cultures in Community Question Answering

    OpenAIRE

    Kayes, Imrul; Kourtellis, Nicolas; Quercia, Daniele; Iamnitchi, Adriana; Bonchi, Francesco

    2015-01-01

    CQA services are collaborative platforms where users ask and answer questions. We investigate the influence of national culture on people's online questioning and answering behavior. For this, we analyzed a sample of 200 thousand users in Yahoo Answers from 67 countries. We measure empirically a set of cultural metrics defined in Geert Hofstede's cultural dimensions and Robert Levine's Pace of Life and show that behavioral cultural differences exist in community question answering platforms. ...

  16. Answers to modernity

    DEFF Research Database (Denmark)

    Petersen, Karen Bjerg

    2008-01-01

    - teacher, learner or curriculum planner positions - result in different strategies or 'answers to modernity'. The research has taken place as a study of e-learning and virtual teachhing of Danish as a second language for adults. The fact that relations in virtual learning are established between physically......, locationally distant'. Based on a case study and interviews with e-learning teachers and learner participants in a virtual classroom setting and on extracts of the curriculum developed for the particular e-learning course, the aim of the paper is to discuss how different positions in an e-learning triangle...... by trying to build 'virtual communities of learning', learners however to experience these disembedded relations, while curriculum planners, on the other hand, seem to intend to take advantage of the conditions of dislocated social relations in e-learning....

  17. Application of Radiation in Nanotechnology

    International Nuclear Information System (INIS)

    The Nanotechnology is one of the fastest growing new areas in science and engineering. The subject arises from the convergence of electronics, physics, chemistry, biology and materials science to create new functional systems of nano-scale dimensions. Nanotechnology deals with science and technology associated with dimensions in the range of 0.1 to 100 nm. The ability to fabricate structures with nano-metric precision is of fundamental importance to any exploitation of nanotechnology. Nanotechnology is predicted to have a major impact on the manufacturing technology in 20 to 30 years from now. The ability to fabricate structures with nano-metric precision is of fundamental importance to any exploitation of nanotechnology. The potential of combining radiation effects with nano-materials has been recognized from the very early stages of nano-science research. In the many uses of nano- structures, and nano-particles in particular, from catalysis, bio-sensing, nano-electronics, magnetic applications including separations, mechano-chemical conversion, and to molecular computing, radiation can play a significant role. The use of radiation, UV beam, electron-beam, or focused ion-beam is clearly central to the fabrication of the nanostructured systems. The relative advantages and deficiencies of each of them are still to be clarified as the technology advances. Whether UV or electron beam will lead to the highest resolution is still debated but it is clear that these techniques offer unmatched reproducibility and very narrow size distribution. Other studies concern formation and synthesis of nano-particles and nano-composites. Radiation synthesis of copper, silver and other metals' nanoparticles is studied. Metal and salt-polymer composites are synthesized by this method. Metal sulphide semiconductors of nano-metric matrices are prepared using gamma irradiation of a suitable solution of monomer, sulphur and metal sources. These products find application in photoluminescent

  18. National Needs Drivers for Nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Yonas, G.; Picraux, S.T.

    2000-10-09

    Societal needs related to demographics, resources, and human behavior will drive technological advances over the next 20 years. Nanotechnology is anticipated to be an important enabler of these advances, and thus maybe anticipated to have significant influence on new systems approaches to solving societal problems as well as on extending current science and technology-based applications. To examine the potential implications of nanotechnology a societal needs-driven approach is taken. Thus the methodology is to present the definition of the problem, and then examine system concepts, technology issues, and promising future directions. We approach the problem definition from a national and global security perspective and identify three key areas involving the condition of the planet, the human condition, and global security. In anticipating societal issues in the context of revolutionary technologies, such as maybe enabled by nanoscience, the importance of working on the entire life cycle of any technological solution is stressed.

  19. Nanotechnological Basis for Advanced Sensors

    CERN Document Server

    Reithmaier, Johann Peter; Kulisch, Wilhelm; Popov, Cyril; Petkov, Plamen

    2011-01-01

    Bringing together experts from 15 countries, this book is based on the lectures and contributions of the NATO Advanced Study Institute on “Nanotechnological Basis for Advanced Sensors” held in Sozopol, Bulgaria, 30 May - 11 June, 2010. It gives a broad overview on this topic, and includes articles on: techniques for preparation and characterization of sensor materials; different types of nanoscaled materials for sensor applications, addressing both their structure (nanoparticles, nanocomposites, nanostructured films, etc.) and chemical nature (carbon-based, oxides, glasses, etc.); and on advanced sensors that exploit nanoscience and nanotechnology. In addition, the volume represents an interdisciplinary approach with authors coming from diverse fields such as physics, chemistry, engineering, materials science and biology. A particular strength of the book is its combination of longer papers, introducing the basic knowledge on a certain topic, and brief contributions highlighting special types of sensors a...

  20. Nanotechnology: a slightly different history

    CERN Document Server

    Schulz, Peter

    2015-01-01

    Many introductory articles and books about nanotechnology have been written to disseminate this apparently new technology, which investigate and manipulates matter at dimension of a billionth of a meter. However, these texts show in general a common feature: there is very little about the origins of this multidisciplinary field. If anything is mentioned at all, a few dates, facts and characters are reinforced, which under the scrutiny of a careful historical digging do not sustain as really founding landmarks of the field. Nevertheless, in spite of these flaws, such historical narratives bring up important elements to understand and contextualize this human endeavor, as well as the corresponding dissemination among the public: would nanotechnology be a cultural imperative?

  1. The effect of nanotechnology on education

    Science.gov (United States)

    Viriyavejakul, Chantana

    2008-04-01

    The research objective was to study 1) the situation and readiness of the Thai education for the integration of nanotechnology and 2) to propose the plans, the strategies and guidelines for educational reform to adapt nanotechnology to the system. The data collection was done by 4 methods: 1) documentary study, 2) observation, 3) informal interviews, and 4) group discussion. The findings revealed that: 1. William Wresch's Theory (1997) was used in this research to study of the situation and readiness of the Thai education for the integration of nanotechnology. 1) Getting connected to nanotechnology by search engine websites, libraries, magazines, books, and discussions with experts. 2) Curriculum integration: nanotechnology should be integrated in many branches of engineering, such as industrial, computer, civil, chemical, electrical, mechanical, etc. 3) Resources for educators: nanotechnology knowledge should be spread in academic circles by publications and the Internet websites. 4) Training and professional resources for teachers: Teachers should be trained by experts in nanotechnology and researchers from the National Nanotechnology Center. This will help trainees get correct knowledge, comprehension, and awareness in order to apply to their professions and businesses in the future. 2. As for the plans, the strategies, and guidelines for educational reform to adapt nanotechnology to the present system, I analyzed the world nanotechnology situation that might have an effect on Thai society. The study is based on the National Plan to Develop Nanotechnology. The goal of this plan is to develop nanotechnology to be the national strategy within 10 years (2004-2013) and have it integrated into the Thai system. There are 4 parts in this plan: 1) nanomaterials, 2) nanoelectronics, 3) nanobiotechnology, and 4) human resources development. Data for human resource development should be worked with the present technology and use the country's resources to produce many

  2. Nanotechnology Safety Self-Study

    Energy Technology Data Exchange (ETDEWEB)

    Grogin, Phillip W. [Los Alamos National Laboratory

    2016-03-29

    Nanoparticles are near-atomic scale structures between 1 and 100 nanometers (one billionth of a meter). Engineered nanoparticles are intentionally created and are used in research and development at Sandia National Laboratories (SNL) and Los Alamos National Laboratory (LANL). This course, Nanotechnology Safety Self-Study, presents an overview of the hazards, controls, and uncertainties associated with the use of unbound engineered nanoscale particles (UNP) in a laboratory environment.

  3. Nanotechnology and preventive arms control

    OpenAIRE

    Altmann, Jürgen

    2005-01-01

    "Nanotechnology (NT) is about analysis and engineering of structures with size between 0.1 and 100 nanometres (1 nm = 10 -9 m). At this scale, new effects occur and the boundaries between physics, chemistry and biology vanish. NT is predicted to lead to stronger but lighter materials, markedly smaller computers with immensely increased power, large and small autonomous robots, tools for manipulation of single molecules, targeted intervention within cells, connections between electronics and n...

  4. Improving Peptide Applications Using Nanotechnology.

    Science.gov (United States)

    Narayanaswamy, Radhika; Wang, Tao; Torchilin, Vladimir P

    2016-01-01

    Peptides are being successfully used in various fields including therapy and drug delivery. With advancement in nanotechnology and targeted delivery carrier systems, suitable modification of peptides has enabled achievement of many desirable goals over-riding some of the major disadvantages associated with the delivery of peptides in vivo. Conjugation or physical encapsulation of peptides to various nanocarriers, such as liposomes, micelles and solid-lipid nanoparticles, has improved their in vivo performance multi-fold. The amenability of peptides to modification in chemistry and functionalization with suitable nanocarriers are very relevant aspects in their use and have led to the use of 'smart' nanoparticles with suitable linker chemistries that favor peptide targeting or release at the desired sites, minimizing off-target effects. This review focuses on how nanotechnology has been used to improve the number of peptide applications. The paper also focuses on the chemistry behind peptide conjugation to nanocarriers, the commonly employed linker chemistries and the several improvements that have already been achieved in the areas of peptide use with the help of nanotechnology. PMID:26279082

  5. Improving Peptide Applications Using Nanotechnology.

    Science.gov (United States)

    Narayanaswamy, Radhika; Wang, Tao; Torchilin, Vladimir P

    2016-01-01

    Peptides are being successfully used in various fields including therapy and drug delivery. With advancement in nanotechnology and targeted delivery carrier systems, suitable modification of peptides has enabled achievement of many desirable goals over-riding some of the major disadvantages associated with the delivery of peptides in vivo. Conjugation or physical encapsulation of peptides to various nanocarriers, such as liposomes, micelles and solid-lipid nanoparticles, has improved their in vivo performance multi-fold. The amenability of peptides to modification in chemistry and functionalization with suitable nanocarriers are very relevant aspects in their use and have led to the use of 'smart' nanoparticles with suitable linker chemistries that favor peptide targeting or release at the desired sites, minimizing off-target effects. This review focuses on how nanotechnology has been used to improve the number of peptide applications. The paper also focuses on the chemistry behind peptide conjugation to nanocarriers, the commonly employed linker chemistries and the several improvements that have already been achieved in the areas of peptide use with the help of nanotechnology.

  6. Photonanomedicine: a convergence of photodynamic therapy and nanotechnology

    Science.gov (United States)

    Obaid, Girgis; Broekgaarden, Mans; Bulin, Anne-Laure; Huang, Huang-Chiao; Kuriakose, Jerrin; Liu, Joyce; Hasan, Tayyaba

    2016-06-01

    As clinical nanomedicine has emerged over the past two decades, phototherapeutic advancements using nanotechnology have also evolved and impacted disease management. Because of unique features attributable to the light activation process of molecules, photonanomedicine (PNM) holds significant promise as a personalized, image-guided therapeutic approach for cancer and non-cancer pathologies. The convergence of advanced photochemical therapies such as photodynamic therapy (PDT) and imaging modalities with sophisticated nanotechnologies is enabling the ongoing evolution of fundamental PNM formulations, such as Visudyne®, into progressive forward-looking platforms that integrate theranostics (therapeutics and diagnostics), molecular selectivity, the spatiotemporally controlled release of synergistic therapeutics, along with regulated, sustained drug dosing. Considering that the envisioned goal of these integrated platforms is proving to be realistic, this review will discuss how PNM has evolved over the years as a preclinical and clinical amalgamation of nanotechnology with PDT. The encouraging investigations that emphasize the potent synergy between photochemistry and nanotherapeutics, in addition to the growing realization of the value of these multi-faceted theranostic nanoplatforms, will assist in driving PNM formulations into mainstream oncological clinical practice as a necessary tool in the medical armamentarium.

  7. EDITORIAL: New developments for Nanotechnology

    Science.gov (United States)

    Welland, Mark

    2007-01-01

    In this first issue of Nanotechnology for 2007 the journal has taken another step forward in its extraordinary growth and development of the past 5 years. The reader will notice two important changes that have been introduced primarily in response to the exponential rise in submissions to the journal: the contents have been restructured into sections and publication will now be weekly. These latest changes, however, are not the only ones that have been made to the journal and its service to authors and readers. A modern journal has many tools at its disposal that journals of even 10 years ago simply did not. Electronic submission and refereeing, web-based publication, author services such as free electronic reprints and an email alerting service, to name but a few. Published by a learned society, Nanotechnology has constantly responded to the needs of authors and readers alike drawing upon the extensive experience and tools of IOP Publishing. Nanotechnology is of course an exploding field and it is therefore perhaps unsurprising to see a growth in the number of submissions to the journal. However, an inspection of the data surrounding submissions over the past 4 years reveals a disproportionate growth in the success of the journal itself. In 2002 there were 419 submitted papers of which 208 were accepted and published in 6 issues. In 2005 we received 75% more submissions over 2002, had a reduced acceptance rate of 44% and published 12 issues. 2006 showed, in just one year, a growth over 2005 of greater than 50% in the number of submissions. This growth of course does present challenges. The paper issues of the journal have been increasing in mass, hence a move to weekly publishing, and the sheer number of papers means that finding an article on a specific topic can be difficult for readers and authors, hence the move to sections. Sections will also help the Editorial Board in ensuring that the journal has a balanced portfolio of papers reflecting the broad

  8. A review of nanotechnology with an emphasis on Nanoplex

    Directory of Open Access Journals (Sweden)

    Rupali Nanasaheb Kadam

    2015-06-01

    Full Text Available The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. A nanoplex is a complex formed by a drug nanoparticle with an oppositely charged polyelectrolyte. Both cationic and anionic drugs form complexes with oppositely charged polyelectrolytes. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. Nanoplex are also easier to prepare. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene drug delivery, drug delivery to the brain and protein and peptide drug delivery.

  9. Potential applications of nanotechnology in bioenergy

    OpenAIRE

    Kramb, Jason

    2011-01-01

    Nanotechnology has an increasingly large impact on a wide range of industries, but its current use in the production of electricity and heat from biomass is limited. This thesis examined the potential impact of nanotechnology on bioenergy production through a literature review and interviews with industry members. Current technologies and methods in use were reviewed, with a focus on fuel handling and combustion systems. Areas in which problems existed were identified and nanotechnologies wit...

  10. Nanotechnology Risk Communication Past and Prologue

    OpenAIRE

    Bostrom, Ann; Löfstedt, Ragnar E.

    2010-01-01

    Nanotechnologies operate at atomic, molecular, and macromolecular scales, at scales where matter behaves differently than at larger scales and quantum effects can dominate. Nanotechnologies have captured the imagination of science fiction writers as science, engineering, and industry have leapt to the challenge of harnessing them. Applications are proliferating. In contrast, despite recent progress the regulatory landscape is not yet coherent, and public awareness of nanotechnology remains lo...

  11. Inventory of nanotechnology companies in Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Appelbaum, Richard, E-mail: rich@global.ucsb.edu [University of California at Santa Barbara, MacArthur Foundation Chair in Sociology and Global & International Studies Co-PI, Center for Nanotechnology and Society, Social Science and Media Studies 2103 (United States); Zayago Lau, Edgar [Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV, Zacatenco)., Multidisciplinary Graduate Programs (Mexico); Foladori, Guillermo [Universidad Autónoma de Zacatecas. Latin American Nanotechnology & Society Network (ReLANS), Unidad Académica en Estudios del Desarrollo (Mexico); Parker, Rachel [Canadian Institute for Advanced Research, Research Programs (Canada); Vazquez, Laura Liliana Villa [Universidad Autónoma de Zacatecas (Mexico); Belmont, Eduardo Robles [UNAM, Institute for Research in Applied Mathematics and Systems (IIMAS) (Mexico); Figueroa, Edgar Ramón Arteaga [Universidad Autónoma de Zacatecas. Latin American Nanotechnology & Society Network (ReLANS), Unidad Académica en Estudios del Desarrollo (Mexico)

    2016-02-15

    This study presents an inventory of 139 nanotechnology companies in Mexico, identifying their geographic distribution, economic sector classification, and position in the nanotechnology value chain. We find that the principal economic sector of nanotechnology-engaged firms involves the manufacture of chemical products, which largely serve as means of production (primary or intermediate materials; instruments and equipment) for industrial processes. The methodology used in this analysis could be replicated in other countries without major modifications.

  12. Importance of Nanotechnology in Civil Engineering

    OpenAIRE

    Kaizar Hossain; Shaik Rameeja

    2015-01-01

    Nanotechnology is an extremely wide term, the definition of which varies from field to field. Most commonly, nanotechnology is defined as “…the understanding, control, and restructuring of matter on the order of nanometers (i.e., less than 100 nm) to create materials with fundamentally new properties and functions” [1]. Nanotechnology refers to the manipulation of individual atoms and molecules, by engineering matter at the atomic level.  At the nanoscale, familiar materials can have dramatic...

  13. Nanotechnology: The Next Challenge for Organics

    OpenAIRE

    Paull, John; Lyons, Kristen

    2008-01-01

    Nanotechnology is the fast growing science of the ultra small; it is creating engineered particles in the size range 1 to 100 nanometres. At this size, materials exhibit novel behaviours. Nanotechnology is a rapidly expanding multibillion dollar industry, with research being heavily promoted by governments, and especially the US. Nanoscale materials are already incorporated into more than 580 consumer products, including food, packaging, cosmetics, clothing and paint. Nanotechnology has been ...

  14. Nanotechnology tools in pharmaceutical R&D

    OpenAIRE

    Kumar, Challa S. S. R.

    2010-01-01

    Nanotechnology is a new approach to problem solving and can be considered as a collection of tools and ideas which can be applied in pharmaceutical industry. Application of nanotechnology tools in pharmaceutical R&D is likely to result in moving the industry from ‘blockbuster drug’ model to ‘personalized medicine’. There are compelling applications in pharmaceutical industry where inexpensive nanotechnology tools can be utilized. The review explores the possibility of categorizing various nan...

  15. Inventory of nanotechnology companies in Mexico

    International Nuclear Information System (INIS)

    This study presents an inventory of 139 nanotechnology companies in Mexico, identifying their geographic distribution, economic sector classification, and position in the nanotechnology value chain. We find that the principal economic sector of nanotechnology-engaged firms involves the manufacture of chemical products, which largely serve as means of production (primary or intermediate materials; instruments and equipment) for industrial processes. The methodology used in this analysis could be replicated in other countries without major modifications

  16. Safety of Nanotechnology in Food Industries

    OpenAIRE

    Amini, Seyed Mohammad; Gilaki, Marzieh; Karchani, Mohsen

    2014-01-01

    The arrival of nanotechnology in various industries has been so rapid and widespread because of its wide-ranging applications in our daily lives. Nutrition and food service is one of the biggest industries to be affected by nanotechnology in all areas, changing even the nature of food itself. Whether it’s farming, food packaging, or the prevention of microbial contamination the major food industries have seen dramatic changes because of nanotechnology. Different nanomaterials such as nanopowd...

  17. EDITORIAL: Nanotechnology impact on sensors Nanotechnology impact on sensors

    Science.gov (United States)

    Brugger, Jürgen

    2009-10-01

    A sensor is a device that responds to a stimulus by generating a functional output induced by a change in some intrinsic properties. We are surrounded by sensors and sensing networks that monitor a multitude of parameters in view of enhancing our safety and quality of life. Sensors assist us in health care and diagnostics, they monitor our environment, our aeroplanes and automobiles, our mobile phones, game consoles and watches, and last but not least, many of our human body functions. Modern sensing systems have greatly benefited in recent decades from advances in microelectronics and microengineering, mainly in view of making sensors smaller, cheaper, more sensitive, more selective, and with a better signal-to-noise ratio, following classical scaling rules. So how about nanotechnology-enabled sensing? Nanoscale features have a great impact on many (though not all) sensing systems, in particular where the surface-to-volume ratio plays a fundamental role, such as in certain chemical and gas sensors. The high surface-to-volume ratios of nanoporous and nanostructured materials have led to their implementation in sensing systems since sensing research first began to engage with the nanotechnology. The surface plasmon resonances of nanostructures have also enriched the scope for developing novel sensing devices. On the other hand, sensors where bulk properties dominate, such as inertial sensors, are less likely to benefit from extreme scaling. Advances in thin film techniques and chemical synthesis have allowed material properties to be tailored to sensing requirements for enhanced performance. These bottom-up fabrication techniques enable parallel fabrication of ordered nanostructures, often in domain-like areas with molecular precision. At the same time the progress in top-down methods such as scanning probe lithography, nanoimprint lithography, soft-lithography and stencil lithography have also facilitated research into sensing and actuating nanotechnology. Although

  18. NANOTECHNOLOGY IN HERBAL MEDICINES AND COSMETICS

    Directory of Open Access Journals (Sweden)

    Alakh N Sahu

    2013-06-01

    Full Text Available Nanophytomedicines are prepared from active phytoconstituents or standardized extracts. The world market for nanomedicine is estimated to reach $130.9 billion by the fiscal year 2016. Liposome nanoparticle (NP with entrapped doxorubicin has been reported to be 300 fold more effective because of better pharmacokinetic ability in treatment of Kaposi sarcoma. NP of paclitaxel is used in the treatment of breast cancer. It has increased water solubility, reduced toxicity and improved therapeutic index. Nanotized herbal drug containing active principles of veteh root, seawort, cassia twig and liquorice root is found to be effective in pulmonary, liver, bone, brain and skin cancer. The in-vivo pharmacokinetic parameters of polymeric nanoparticles containing curcumin reveal at least 9 fold increase in oral bioavailability when compared to curcumin administered with piperine as absorption enhancer. The green nanotechnology utilizes plant based phytochemicals in the overall synthesis and architecture of NP. Cumin and gum arabic are used for synthesis of gold NP that has reduced toxicity to living organism and environment. Bhasma used in Ayurveda is ancient but ultra modern nanomedicine prepared from metal. Swarna bhasma has particle size of 56 nm. NP in cosmetics has been used safely and effectively. NP ingredients like Zno and TiO2 have properties that provide greater degree of protection from sun. Liposome containing Aloe vera extract in size range less than 200 nm diameter has shown higher rate of cell proliferation and increased synthesis of collagenase in in vitro test using human skin fibroblast and epidermal keratinocytes.

  19. Cooperative answers in database systems

    Science.gov (United States)

    Gaasterland, Terry; Godfrey, Parke; Minker, Jack; Novik, Lev

    1993-01-01

    A major concern of researchers who seek to improve human-computer communication involves how to move beyond literal interpretations of queries to a level of responsiveness that takes the user's misconceptions, expectations, desires, and interests into consideration. At Maryland, we are investigating how to better meet a user's needs within the framework of the cooperative answering system of Gal and Minker. We have been exploring how to use semantic information about the database to formulate coherent and informative answers. The work has two main thrusts: (1) the construction of a logic formula which embodies the content of a cooperative answer; and (2) the presentation of the logic formula to the user in a natural language form. The information that is available in a deductive database system for building cooperative answers includes integrity constraints, user constraints, the search tree for answers to the query, and false presuppositions that are present in the query. The basic cooperative answering theory of Gal and Minker forms the foundation of a cooperative answering system that integrates the new construction and presentation methods. This paper provides an overview of the cooperative answering strategies used in the CARMIN cooperative answering system, an ongoing research effort at Maryland. Section 2 gives some useful background definitions. Section 3 describes techniques for collecting cooperative logical formulae. Section 4 discusses which natural language generation techniques are useful for presenting the logic formula in natural language text. Section 5 presents a diagram of the system.

  20. NCL Objective #5 - Nanotechnology Characterization Lab (NCL)

    Science.gov (United States)

    Nanotechnology Characterization Lab (NCL) Objective #5: Engage and Facilitate Academic and Industrial-based Knowledge Sharing of Nanomaterial Performance Data and Behavior Resulting from Pre-Clinical Testing.

  1. Current status of nanotechnology in urology

    Directory of Open Access Journals (Sweden)

    Suresh K. Goyal

    2016-08-01

    Full Text Available Nanotechnology has been investigated for its applications in medicine. The objective of this review was to summarize the current applications of nanotechnology in Urology. A systematic search of literature was performed and relevant articles were analyzed with specific reference to applications in Urology. Nanotechnology has applications in diagnostic urology like in uroimaging using nanoparticles and nanosensors. It has therapeutic applications in infections, malignancies, genetic disease using targeted drug delivery, gene transfers, nano device-based manipulations etc. Nanotechnology has many applications in Urology. More efforts are required to make these applications practically feasible and affordable. [Int J Res Med Sci 2016; 4(8.000: 3114-3120

  2. The Formation of Data on Nanotechnological Processes

    Directory of Open Access Journals (Sweden)

    Oleynik Olga Stepanovna

    2015-05-01

    Full Text Available The article presents the statistical monitoring of the main trends of nanotechnology development in Russia, as well as the review of the modern programs and documents devoted to urgent issues of nanotechnology development. The formation of system of statistical monitoring of nanotechnologies development in the Russian Federation includes the development of methodology and tools of statistical supervision over creation, commercialization, the use of nanotechnologies, and also the nanotechnological production. The authors carry out the analysis of the main directions and structure of co-funding of “The Program of nanotech industry development in the Russian Federation till 2015”. The sources of official statistical data on nanotechnologies in Russia are considered. The purpose of forming this essentially new direction of statistics consists in the creation of system of collecting, processing and submission of the regular, systematized and complex data which are adequately reflecting the state, the level of development and the prospects of nanotechnological sphere capacity which provide informational support to state policy and adoption of reasonable administrative decisions. The authors describe the system of statistical observations in the sphere of nanotechnologies. Today the statistics of nanotechnologies in Russia remains at the stage of formation and modernization according to the international standards, being supplemented every year with the new indicators which allow investigating different sides and tendencies of nanotech industry development. Nowadays the following aspects of the activity connected with nanotechnologies have already being studied by means of statistical methods: scientific research and developments; creation and use of nanotechnologies; demand for staff; production, including the innovative one.

  3. Nanotechnology in electrocatalysis for energy

    CERN Document Server

    Lavacchi, Alessandro; Vizza, Francesco

    2014-01-01

    This book focuses on nanotechnology in electrocatalysis for energy applications. In particular the book covers nanostructured electrocatalysts for low temperature fuel cells, low temperature electrolyzers and electrochemical valorization. The function of this book is to provide an introduction to basic principles of electrocatalysis, together with a review of the main classes of materials and electrode architectures. This book will illustrate the basic ideas behind material design and provide an introductory sketch of current research focuses. The easy-to-follow three part book focuses on majo

  4. Question Answering for Collaborative Learning with Answer Quality Predictor

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2013-06-01

    Full Text Available The increasing advances of Internet Technologies in all application domains have changed life styles and interactions. With the rapid development of E-Learning, collaborative learning is an important for teaching, learning methods and strategies. Studies over the years shown that students had actively and more interactively involved in a classroom discussion to gain their knowledge. Students can ask their questions to the classroom discussion when they want to collaborate with others, asking one another for information, evaluating one another’s ideas. Therein, the activity allowing one question has many answer or information that should be selected. Every answer has a weighting and its very subjective to select it. In this paper, we introduce question answering for collaborative learning with answer quality predictor. By using answer quality predictor the quality of the information could be determined. Through the process of collaborative learning, the knowledge base will be enriched for future question answering. Further, not only the student could get answers form others but also provided by the system.

  5. Nanotechnology based diagnostics for neurological disorders

    International Nuclear Information System (INIS)

    Nanotechnology involves probing and manipulating matter at the molecular level. Nanotechnology based molecular diagnostics have the potential to alleviate the suffering caused by many diseases, including neurological disorders, due to the unique properties of nanomaterials. Most neurological illnesses are multifactorial conditions and many of these are also classified as neurobehavioral disorders. Alzheimer's disease, Parkinson's disease, Huntington disease, cerebral ischemia, epilepsy, schizophrenia and autism spectrum disorders like Rett syndrome are some examples of neurological disorders that could be better treated, diagnosed, prevented and possibly cured using nanotechnology. In order to improve the quality of life for disease afflicted people, a wide range of nanomaterials that include gold and silica nanoparticles, quantum dots and DNA along with countless other forms of nanotechnology have been investigated regarding their usefulness in advancing molecular diagnostics. Other small scaled materials like viruses and proteins also have potential for use as molecular diagnostic tools. Information obtained from nanotechnology based diagnostics can be stored and manipulated using bioinformatics software. More advanced nanotechnology based diagnostic procedures for the acquisition of even greater proteomic and genomic knowledge can then be developed along with better ways to fight various diseases. Nanotechnology also has numerous applications besides those related to biotechnology and medicine. In this article, we will discuss and analyze many novel nanotechnology based diagnostic techniques at our disposal today. (author)

  6. Engaging Undergraduates through Interdisciplinary Research in Nanotechnology

    Science.gov (United States)

    Goonewardene, Anura U.; Offutt, Christine; Whitling, Jacqueline; Woodhouse, Donald

    2012-01-01

    To recruit and retain more students in all science disciplines at our small (5,000 student) public university, we implemented an interdisciplinary strategy focusing on nanotechnology and enhanced undergraduate research. Inherently interdisciplinary, the novelty of nanotechnology and its growing career potential appeal to students. To engage…

  7. Engines of Second Creation: Stories about Nanotechnology

    Science.gov (United States)

    Shew, Ashley

    2013-01-01

    We are in a position today to appreciate the ambiguity of technologies: that they are good, and bad, and neutral and present challenges in different ways. Reading U.S. national nanotechnology documents and histories of nanotechnology, one finds that rhetoric idealizing progress without serious consideration of negative side-effects remains…

  8. Grand Challenges: Nanotechnology and the Social Studies

    Science.gov (United States)

    Manfra, Meghan McGlinn

    2013-01-01

    This article explores a multidisciplinary lesson on nanotechnology that can provide an effective means for teaching about both STEM and social studies topics. This approach encourages students to consider the "role that science and technology play in our lives and in our cultures." The extraordinary promise of nanotechnology, however, is…

  9. Nanotechnology Education: Contemporary Content and Approaches

    Science.gov (United States)

    Ernst, Jeremy V.

    2009-01-01

    Nanotechnology is a multidisciplinary field of research and development identified as a major priority in the United States. Progress in science and engineering at the nanoscale is critical for national security, prosperity of the economy, and enhancement of the quality of life. It is anticipated that nanotechnology will be a major transitional…

  10. Pharmaceutical nanotechnology : unmet needs in drug delivery

    NARCIS (Netherlands)

    Crommelin, D.J.A.; Park, K.; Florence, A.

    2010-01-01

    Nanotechnology has been gaining interest within and outside the scientific community. Conferences addressing different aspects of this rapidly growing field are organized at many different places. In May 2009 the LTS Academy organized a two-day workshop to discuss the relevance of nanotechnology to

  11. Nanotechnology based diagnostics for neurological disorders

    Energy Technology Data Exchange (ETDEWEB)

    Kurek, Nicholas S.; Chandra, Sathees B., E-mail: schandra@roosevelt.edu [Department of Biological, Chemical and Physical Sciences, Roosevelt University, Chicago, IL (United States)

    2012-07-01

    Nanotechnology involves probing and manipulating matter at the molecular level. Nanotechnology based molecular diagnostics have the potential to alleviate the suffering caused by many diseases, including neurological disorders, due to the unique properties of nanomaterials. Most neurological illnesses are multifactorial conditions and many of these are also classified as neurobehavioral disorders. Alzheimer's disease, Parkinson's disease, Huntington disease, cerebral ischemia, epilepsy, schizophrenia and autism spectrum disorders like Rett syndrome are some examples of neurological disorders that could be better treated, diagnosed, prevented and possibly cured using nanotechnology. In order to improve the quality of life for disease afflicted people, a wide range of nanomaterials that include gold and silica nanoparticles, quantum dots and DNA along with countless other forms of nanotechnology have been investigated regarding their usefulness in advancing molecular diagnostics. Other small scaled materials like viruses and proteins also have potential for use as molecular diagnostic tools. Information obtained from nanotechnology based diagnostics can be stored and manipulated using bioinformatics software. More advanced nanotechnology based diagnostic procedures for the acquisition of even greater proteomic and genomic knowledge can then be developed along with better ways to fight various diseases. Nanotechnology also has numerous applications besides those related to biotechnology and medicine. In this article, we will discuss and analyze many novel nanotechnology based diagnostic techniques at our disposal today. (author)

  12. Nanotechnologies in food and meat processing

    Directory of Open Access Journals (Sweden)

    Lech Ozimek

    2010-12-01

    Full Text Available This paper highlights the evolution of nanoscience and nanotechnologies from the global perspective and their potential application in food systems including meat processing. Nanotechnology has its roots in a talk delivered in 1959 by physicist Richard Feynman to the American Physical Society. Nanoscience refers to components properties at nanoscale and nanotechnology refers to process or processes used in the manufacture and/or biofabrication of new materials measured at nanoscale. Nanotechnology offers a wide range of opportunities for the development of innovative products and applications in food system. Functional foods, nutraceuticals, bioactives, farmafoods, etc. are very recent example of it. Nanotechnology and nanomaterials are a natural part of food processing and conventional foods, because the characteristic properties of many foods rely on nanometer sized components. Some of the areas where nanotechnologies are set to make a difference in meat processing in near future relate to intelligent packaging of meat and meat products, meat derived bioactive peptides, pro- and pre-biotics inclusion in processed meat products, fat based nanoemulsions for antioxidant delivery, nanosensors and nanotracers for meat biosecurity tracing and nanostructured meat products with defined functions. New horizons for nanotechnology in meat science may be achieved by further research on nanoscale structures and methods to control interactions between single molecules. However, it shall be mentioned that nanotechnologies and nanomaterials are calling for their regulations and safety assessment as some of the materials are new and their safety never tested before.

  13. What drives public acceptance of nanotechnology?

    Science.gov (United States)

    Currall, Steven C.; King, Eden B.; Lane, Neal; Madera, Juan; Turner, Stacey

    2006-12-01

    How do the risks and benefits of nanotechnology, as viewed by the public, compare with those associated with other technologies such as genetically modified organisms, stem cells, biotechnology and nuclear power? And when deciding to use a specific nanotechnology product, will consumers consider the risks, the benefits, or both? We report the first large-scale empirical analyses of these questions.

  14. Computational Nanotechnology Molecular Electronics, Materials and Machines

    Science.gov (United States)

    Srivastava, Deepak; Biegel, Bryan A. (Technical Monitor)

    2002-01-01

    This presentation covers research being performed on computational nanotechnology, carbon nanotubes and fullerenes at the NASA Ames Research Center. Topics cover include: nanomechanics of nanomaterials, nanotubes and composite materials, molecular electronics with nanotube junctions, kinky chemistry, and nanotechnology for solid-state quantum computers using fullerenes.

  15. Material Binding Peptides for Nanotechnology

    Directory of Open Access Journals (Sweden)

    Urartu Ozgur Safak Seker

    2011-02-01

    Full Text Available Remarkable progress has been made to date in the discovery of material binding peptides and their utilization in nanotechnology, which has brought new challenges and opportunities. Nowadays phage display is a versatile tool, important for the selection of ligands for proteins and peptides. This combinatorial approach has also been adapted over the past decade to select material-specific peptides. Screening and selection of such phage displayed material binding peptides has attracted great interest, in particular because of their use in nanotechnology. Phage display selected peptides are either synthesized independently or expressed on phage coat protein. Selected phage particles are subsequently utilized in the synthesis of nanoparticles, in the assembly of nanostructures on inorganic surfaces, and oriented protein immobilization as fusion partners of proteins. In this paper, we present an overview on the research conducted on this area. In this review we not only focus on the selection process, but also on molecular binding characterization and utilization of peptides as molecular linkers, molecular assemblers and material synthesizers.

  16. Nanotechnology research for aerospace applications

    Science.gov (United States)

    Agee, Forrest J.; Lozano, Karen; Gutierrez, Jose M.; Chipara, Mircea; Thapa, Ram; Chow, Alice

    2009-04-01

    Nanotechnology is impacting the future of the military and aerospace. The increasing demands for high performance and property-specific applications are forcing the scientific world to take novel approaches in developing programs and accelerating output. CONTACT or Consortium for Nanomaterials for Aerospace Commerce and Technology is a cooperative nanotechnology research program in Texas building on an infrastructure that promotes collaboration between universities and transitioning to industry. The participants of the program include the US Air Force Research Laboratory (AFRL), five campuses of the University of Texas (Brownsville, Pan American, Arlington, Austin, and Dallas), the University of Houston, and Rice University. Through the various partnerships between the intellectual centers and the interactions with AFRL and CONTACT's industrial associates, the program represents a model that addresses the needs of the changing and competitive technological world. Into the second year, CONTACT has expanded to twelve projects that cover four areas of research: Adaptive Coatings and Surface Engineering, Nano Energetics, Electromagnetic Sensors, and Power Generation and Storage. This paper provides an overview of the CONTACT program and its projects including the research and development of new electrorheological fluids with nanoladen suspensions and composites and the potential applications.

  17. Nanotechnology policy in Korea for sustainable growth

    International Nuclear Information System (INIS)

    Korea has become one of the leading countries in nanotechnology along with the U.S., Japan, and Germany. Since 2001, the Korean Government established the “Nanotechnology Development Plan.” Since then, the trend in nanotechnology is steadily changing from fundamental research to application-driven technologies. In this paper, we examine the nanotechnology development and policy during the past decade, which includes the investments in R and D, infrastructure, and education. The Third Phase (2011–2020) on clean nanotechnology convergence and integration in information, energy, and the environmental sector is also given. Furthermore, the program on long-term strategy dealing with sustainability in resolving future societal demand and plans for sustainable energy and environmental activities will be discussed in depth. The outcomes and national evaluations of research and education are also given.

  18. Taking a precautionary approach to nanotechnology

    Directory of Open Access Journals (Sweden)

    Dónal P. O’Mathúna

    2011-07-01

    Full Text Available Nanotechnology is developing at a rapid pace. Concerns have been raised about the risks nanotechnology may carry for human health and the environment. The precautionary principle has developed within environmental ethics as a way to reduce the risk of harm with emerging technologies. It has been incorporated into a number of documents addressing nanotechnology risks, including the European Commission’s Code of Conduct for Responsible Nanosciences and Nanotechnologies Research. The central features of the precautionary principle are reviewed here. These include addressing situations of scientific uncertainty and serious or irreversible harm, developing a proportionate response, and having reasonable grounds for concern. These factors will be applied to carbon nanotubes to demonstrate how the precautionary principle can lead to practical guidelines during the development of nanotechnology.

  19. Nanotechnology applications in medicine and dentistry.

    Science.gov (United States)

    Gupta, Jyoti

    2011-05-01

    Nanotechnology, or nanoscience, refers to the research and development of an applied science at the atomic, molecular, or macromolecular levels (i.e. molecular engineering, manufacturing). The prefix "nano" is defined as a unit of measurement in which the characteristic dimension is one billionth of a unit. Although the nanoscale is small in size, its potential is vast. As nanotechnology expands in other fields, clinicians, scientists, and manufacturers are working to discover the uses and advances in biomedical sciences. Applications of nanotechnology in medical and dental fields have only approached the horizon with opportunities and possibilities for the future that can only be limited by our imagination. This paper provides an early glimpse of nanotechnology applications in medicine and dentistry to illustrate their potentially far-reaching impacts on clinical practice. It also narrates the safety issues concerning nanotechnology applications.

  20. Food neophobia, nanotechnology and satisfaction with life

    DEFF Research Database (Denmark)

    Schnettler, Berta; Crisóstomo, Gloria; Sepúlveda, José;

    2013-01-01

    This study investigates the relationship between food neophobia, satisfaction with life and food-related life, and acceptance of the use of nanotechnology in food production. Questionnaire data was collected from a sample of 400 supermarket shoppers in southern Chile. The questionnaire measured...... knowledge of nanotechnology and willingness to purchase food products involving nanotechnology, and included the SWLS (Satisfaction with Life Scale), SWFL (Satisfaction with Foodrelated Life) and FNS (Food Neophobia Scale) scales. Using cluster analysis, four consumer types were distinguished...... with significant differences in their scores on the SWLS, SWFL and FNS. The types differed in their knowledge of nanotechnology, willingness to purchase foods involving nanotechnology, age, socioeconomic level and lifestyle. The least food-neophobic type had the highest levels of satisfaction with life...

  1. HPV Vaccine - Questions and Answers

    Science.gov (United States)

    ... and Media Resources News Newsletters Events Redirect for HPV Vaccine FAQ Recommend on Facebook Tweet Share Compartir ... to the address below. http://www.cdc.gov/hpv/parents/questions-answers.html File Formats Help: How ...

  2. Questions and Answers about Stroke

    Science.gov (United States)

    ... Find People About NINDS Questions and Answers About Stroke What is a stroke? A stroke occurs when blood flow to the ... need to function. What are the types of strokes? A stroke can occur in two ways. In ...

  3. Cryosurgery in Cancer Treatment: Questions and Answers

    Science.gov (United States)

    ... any complications or side effects? What are the advantages of cryosurgery? What are the disadvantages of cryosurgery? ... or to distant parts of the body. Some advantages of cryosurgery are that the procedure can be ...

  4. Nanotechnology for in vitro neuroscience

    Science.gov (United States)

    Cooper, Daniel R.; Nadeau, Jay L.

    2009-11-01

    Neurons in vitro are different from any other cell types in their sensitivity and complexity. Growing, differentiating, transfecting, and recording from single neurons and neuronal networks all present particular challenges. Some of the difficulties arise from the small scale of cellular structures, and have already seen substantial advances due to nanotechnology, particularly highly fluorescent semiconductor nanoparticles. Other issues have less obvious solutions, but the complex and often surprising way that novel nanomaterials react with cells have suggested some revolutionary approaches. We review some of the ways nanomaterials and nanostructures can contribute to in vitro neuroscience, with a particular focus on emphasizing techniques that are widely accessible to many laboratories and on providing references to protocols and methods. The issues of nanotoxicology of greatest interest to cultured neurons are discussed. Finally, we present some future trends and challenges in nano-neuroscience.

  5. Nanotechnology and Nanotoxicology in Retinopathy

    Directory of Open Access Journals (Sweden)

    Tae Geol Lee

    2011-11-01

    Full Text Available Nanoparticles are nanometer-scaled particles, and can be utilized in the form of nanocapsules, nanoconjugates, or nanoparticles themselves for the treatment of retinopathy, including angiogensis-related blindness, retinal degeneration, and uveitis. They are thought to improve the bioavailability in the retina and the permeability of therapeutic molecules across the barriers of the eye, such as the cornea, conjunctiva, and especially, blood-retinal barriers (BRBs. However, consisting of multiple neuronal cells, the retina can be the target of neuronal toxicity of nanoparticles, in common with the central and peripheral nervous system. Furthermore, the ability of nanoparticles to pass through the BRBs might increase the possibility of toxicity, simultaneously promoting distribution in the retinal layers. In this regard, we discussed nanotechnology and nanotoxicology in the treatment of retinopathy.

  6. Nanotechnology for the energy challenge

    CERN Document Server

    2013-01-01

    With the daunting energy challenges faced by Mankind in the 21st century, revolutionary new technologies will be the key to a clean, secure and sustainable energy future. Nanostructures often have surprising and very useful capabilities and are thus paving the way for new methodologies in almost every kind of industry. This exceptional monograph provides an overview of the subject, and presents the current state of the art with regard to different aspects of sustainable production, efficient storage and low-impact use of energy. Comprised of eighteen chapters, the book is divided in three thematic parts: Part I Sustainable Energy Production covers the main developments of nanotechnology in clean energy production and conversion, including photovoltaics, hydrogen production, thermal-electrical energy conversion and fuel cells. Part II Efficient Energy Storage is concerned with the potential use of nanomaterials in more efficient energy storage systems such as advanced batteries, supercapacitors and hydrogen st...

  7. Journal information flow in nanotechnology

    International Nuclear Information System (INIS)

    The nanotechnology development is accompanied by an intensive growth of information flow which is specially noticeable as applied to journal information flow. Now over the world there are the 69 nano-titled journals with the impact factor and/or a settled periodicity as well as the 70 those which lack stability periodicity and are in an organization stage. Only 49 nano-titled have the impact factor with the comparatively high mean value of about 3.44. The domestic nano-titled journals published in Russia, India, China, and other countries are also considered. The attention is taken that in the 2006–2010 period the 95 new nano-titled journals were organized and in 2011 this process is continuing and seems to be the most impressive. Many nano-related journals (including classical physical, chemical and materials science ones) are also described and discussed.

  8. Nanotechnologies applied to building sector.

    Directory of Open Access Journals (Sweden)

    Massimo Rossetti

    2009-06-01

    Full Text Available The article presents the state of the art and the most important tendencies of one of the most promising sectors within the scenario of technological innovation in constructions: the application to materials and components of the nanotechnologies, a kind of technologies that modify at infinitesimal scale the physical, chemical and mechanical characteristics of materials in a way which is not with the traditional technologies. A sector that has seen in the last years an exponential increase of technical solutions and brevets, most of them being born in other industrial sectors and then transferred and suited for the construction industry, to improve the performances of the materials used in terms of maintenance and conservation, performances, energy saving, aesthetics.

  9. Food neophobia, nanotechnology and satisfaction with life.

    Science.gov (United States)

    Schnettler, Berta; Crisóstomo, Gloria; Sepúlveda, José; Mora, Marcos; Lobos, Germán; Miranda, Horacio; Grunert, Klaus G

    2013-10-01

    This study investigates the relationship between food neophobia, satisfaction with life and food-related life, and acceptance of the use of nanotechnology in food production. Questionnaire data was collected from a sample of 400 supermarket shoppers in southern Chile. The questionnaire measured knowledge of nanotechnology and willingness to purchase food products involving nanotechnology, and included the SWLS (Satisfaction with Life Scale), SWFL (Satisfaction with Food-related Life) and FNS (Food Neophobia Scale) scales. Using cluster analysis, four consumer types were distinguished with significant differences in their scores on the SWLS, SWFL and FNS. The types differed in their knowledge of nanotechnology, willingness to purchase foods involving nanotechnology, age, socioeconomic level and lifestyle. The least food-neophobic type had the highest levels of satisfaction with life and with food-related life and also had the highest acceptance of packaging and foods produced with nanotechnology. The results suggest that the degree of food neophobia is associated with satisfaction with life and with food-related life, as well as with the acceptance of products with nanotechnological applications.

  10. Nanotechnology impact on the automotive industry.

    Science.gov (United States)

    Wong, Kaufui V; Paddon, Patrick A

    2014-01-01

    Nanotechnology has been implemented widely in the automotive industry. This technology is particularly useful in coatings, fabrics, structural materials, fluids, lubricants, tires, and preliminary applications in smart glass/windows and video display systems. A special sub-class of improved materials, alternative energy, has also seen a boost from advances in nanotechnology, and continues to be an active research area. A correlation exists in the automotive industry between the areas with increased nanotechnology incorporation and those with increased profit margins via improvements and customer demands. PMID:25360613

  11. A social shaping perspective on nanotechnologies

    DEFF Research Database (Denmark)

    Clausen, Christian; Jørgensen, Michael Søgaard

    2005-01-01

    in areas where visions are manifold and applications and markets are non-existing or unclear. The emerging idea of 'nanotechnologies' is an example of this kind, where techno-economic networks are unstable or under construction and consequences are difficult, if not impossible to evaluate. The paper...... explores the potential of a social shaping of technology approach in the area of emerging nano-technologies and debate the methodological aspects based on an ongoing Danish foresight project concerned with environmental risks and opportunities in nanotechnologies. The focus is on the identification...

  12. Nanotechnologies for biomedical science and translational medicine.

    Science.gov (United States)

    Heath, James R

    2015-11-24

    In 2000 the United States launched the National Nanotechnology Initiative and, along with it, a well-defined set of goals for nanomedicine. This Perspective looks back at the progress made toward those goals, within the context of the changing landscape in biomedicine that has occurred over the past 15 years, and considers advances that are likely to occur during the next decade. In particular, nanotechnologies for health-related genomics and single-cell biology, inorganic and organic nanoparticles for biomedicine, and wearable nanotechnologies for wellness monitoring are briefly covered.

  13. Colloid and interface chemistry for nanotechnology

    CERN Document Server

    Kralchevsky, Peter

    2013-01-01

    Colloid and interface science dealt with nanoscale objects for nearly a century before the term nanotechnology was coined. An interdisciplinary field, it bridges the macroscopic world and the small world of atoms and molecules. Colloid and Interface Chemistry for Nanotechnology is a collection of manuscripts reflecting the activities of research teams that have been involved in the networking project Colloid and Interface Chemistry for Nanotechnology (2006-2011), Action D43, the European Science Foundation. The project was a part of the intergovernmental framework for Cooperation in Science an

  14. Nanotechnology in biorobotics: opportunities and challenges

    Energy Technology Data Exchange (ETDEWEB)

    Ricotti, Leonardo, E-mail: l.ricotti@sssup.it; Menciassi, Arianna [Scuola Superiore Sant’Anna, The BioRobotics Institute (Italy)

    2015-02-15

    Nanotechnology recently opened a series of unexpected technological opportunities that drove the emergence of novel scientific and technological fields, which have the potential to dramatically change the lives of millions of citizens. Some of these opportunities have been already caught by researchers working in the different fields related to biorobotics, while other exciting possibilities still lie on the horizon. This article highlights how nanotechnology applications recently impacted the development of advanced solutions for actuation and sensing and the achievement of microrobots, nanorobots, and non-conventional larger robotic systems. The open challenges are described, together with the most promising research avenues involving nanotechnology.

  15. From Diagnosis to Treatment: Clinical Applications of Nanotechnology in Thoracic Surgery.

    Science.gov (United States)

    Digesu, Christopher S; Hofferberth, Sophie C; Grinstaff, Mark W; Colson, Yolonda L

    2016-05-01

    Nanotechnology is an emerging field with potential as an adjunct to cancer therapy, particularly thoracic surgery. Therapy can be delivered to tumors in a more targeted fashion, with less systemic toxicity. Nanoparticles may aid in diagnosis, preoperative characterization, and intraoperative localization of thoracic tumors and their lymphatics. Focused research into nanotechnology's ability to deliver both diagnostics and therapeutics has led to the development of nanotheranostics, which promises to improve the treatment of thoracic malignancies through enhanced tumor targeting, controlled drug delivery, and therapeutic monitoring. This article reviews nanoplatforms, their unique properties, and the potential for clinical application in thoracic surgery. PMID:27112260

  16. Nanotechnology and business opportunities: scenarios as awareness instrument

    OpenAIRE

    Knol, Erik

    2005-01-01

    For a few years now, nanotechnology has been recognised as a promising new growth innovator. This leads to a shift from the exploration of nanotechnology knowledge towards a phase of exploitation. The coming years this commercialisation of nanotechnology will be extended. Nanotechnology is a disruptive technology phenomenon, which leads to more difficulties in overseeing business opportunities. Additionally, the fact that high-tech small firms, especially those dealing with nanotechnology...

  17. Nanotechnology, Society, and Freshman, Oh My!

    Science.gov (United States)

    Tahan, Charles; Crone, Wendy; Ellison, Karin; Leung, Ricky; Miller, Clark; Zenner, Greta

    2005-03-01

    Nanotechnology has emerged as a broad and exciting, yet ill-defined, field of scientific research and technological innovation. Important questions have arisen about the technology's potential economic, social, and environmental implications by prominent technology leaders, nanotechnology boosters, science fiction authors, policy officials, and environmental organizations. We have developed a freshman-level seminar course that offers an opportunity for students from a wide range of disciplines, including the natural and social sciences, humanities, and engineering, to learn about nanoscience and nanotechnology and to explore these questions and reflect on the broader place of technology in modern societies. The course is built around active learning methods and seeks to develop the students' critical thinking and research skills, written and verbal communication abilities, and general knowledge of nanotech. Continuous assessment is used to gain information about how effective the class discussions are and how well the overall course enhances students' understanding of the interaction between nanotechnology and society.

  18. Microspheres and Nanotechnology for Drug Delivery.

    Science.gov (United States)

    Jóhannesson, Gauti; Stefánsson, Einar; Loftsson, Thorsteinn

    2016-01-01

    Ocular drug delivery to the posterior segment of the eye can be accomplished by invasive drug injections into different tissues of the eye and noninvasive topical treatment. Invasive treatment involves the risks of surgical trauma and infection, and conventional topical treatments are ineffective in delivering drugs to the posterior segment of the eye. In recent years, nanotechnology has become an ever-increasing part of ocular drug delivery. In the following, we briefly review microspheres and nanotechnology for drug delivery to the eye, including different forms of nanotechnology such as nanoparticles, microparticles, liposomes, microemulsions and micromachines. The permeation barriers and anatomical considerations linked to ocular drug delivery are discussed and a theoretical overview on drug delivery through biological membranes is given. Finally, in vitro, in vivo and human studies of x03B3;-cyclodextrin nanoparticle eyedrop suspensions are discussed as an example of nanotechnology used for drug delivery to the eye. PMID:26501994

  19. Microspheres and Nanotechnology for Drug Delivery.

    Science.gov (United States)

    Jóhannesson, Gauti; Stefánsson, Einar; Loftsson, Thorsteinn

    2016-01-01

    Ocular drug delivery to the posterior segment of the eye can be accomplished by invasive drug injections into different tissues of the eye and noninvasive topical treatment. Invasive treatment involves the risks of surgical trauma and infection, and conventional topical treatments are ineffective in delivering drugs to the posterior segment of the eye. In recent years, nanotechnology has become an ever-increasing part of ocular drug delivery. In the following, we briefly review microspheres and nanotechnology for drug delivery to the eye, including different forms of nanotechnology such as nanoparticles, microparticles, liposomes, microemulsions and micromachines. The permeation barriers and anatomical considerations linked to ocular drug delivery are discussed and a theoretical overview on drug delivery through biological membranes is given. Finally, in vitro, in vivo and human studies of x03B3;-cyclodextrin nanoparticle eyedrop suspensions are discussed as an example of nanotechnology used for drug delivery to the eye.

  20. Nanotechnology - A path forward for developing nations

    Science.gov (United States)

    Shah, S. Ismat; Powers, Thomas M.

    2015-10-01

    One of the major issues with technology in general, and nanotechnology in particular, is that it could exacerbate the divide between developed and developing nations. If the benefits of the research do not flow beyond the national and geographical borders of the traditional major bastions of R&D, these benefits will not be equally and globally available. The consequence is that the technological divide becomes wider at the expense of mutual reliance. As much as developed nations need to rethink the strategy and the policy to bring nanotechnology products to market with the goal of global prosperity, developing nations cannot afford to simply wait for the lead from the developed nations. In the spirit of collaboration and collegiality, we describe issues with the current practices in nanotechnology R&D in the developing world and suggest a path for nanotechnology research in energy, water and the environment that developing nations could follow in order to become contributors rather than simply consumers.

  1. Proximity and Collaboration in European Nanotechnology

    NARCIS (Netherlands)

    Cunningham, S.W.; Werker, C.

    2011-01-01

    Collaborations are particularly important for the development and deployment of technology. We analyze the influence of organizational, technological and geographical proximity on European nanotechnology collaborations with the help of a publication dataset and additional geographical information. W

  2. Engineers explore environmental concerns of nanotechnology

    OpenAIRE

    Nystrom, Lynn A.

    2010-01-01

    As researchers around the world hasten to employ nanotechnology to improve production methods for its various applications that range from manufacturing materials to creating new pharmaceutical drugs, a separate but equally compelling challenge exists.

  3. Advances in Nanotechnology for Restorative Dentistry

    Directory of Open Access Journals (Sweden)

    Zohaib Khurshid

    2015-02-01

    Full Text Available Rationalizing has become a new trend in the world of science and technology. Nanotechnology has ascended to become one of the most favorable technologies, and one which will change the application of materials in different fields. The quality of dental biomaterials has been improved by the emergence of nanotechnology. This technology manufactures materials with much better properties or by improving the properties of existing materials. The science of nanotechnology has become the most popular area of research, currently covering a broad range of applications in dentistry. This review describes the basic concept of nanomaterials, recent innovations in nanomaterials and their applications in restorative dentistry. Advances in nanotechnologies are paving the future of dentistry, and there are a plenty of hopes placed on nanomaterials in terms of improving the health care of dental patients.

  4. NCL Objective #3 - Nanotechnology Characterization Lab (NCL)

    Science.gov (United States)

    The Nanotechnology Characterization Lab (NCL) Objective #3: Identify and Characterize Critical Parameters Related to Nanomaterials' Absorption, Distribution, Metabolism, Excretion, and Acute Toxicity (ADME/Tox) Profile in Animal Models.

  5. NCL Objective #4 - Nanotechnology Characterization Lab (NCL)

    Science.gov (United States)

    The Nanotechnology Characterization Lab (NCL) Objective #4: Examine the Biological and Functional Characteristics of MultiComponent/Combinatorial Aspects of Nanoscaled Therapeutic, Molecular and Clinical Diagnostics, and Detection Platforms.

  6. Nanotechnology-based approaches for regenerative medicine and biosensing

    Science.gov (United States)

    Solanki, Aniruddh P.

    using insoluble cues. The cellular microenvironment, consisting for the extracellular matrix (ECM) was modified by the use of nanostructures, to deliver siRNA into NSCs to enhance neuronal differentiation. Nanotopography-mediated reverse uptake of only the siRNA molecules from the ECM was achieved by the NSCs. NSC differentiation was also controlled by the use of protein micropatterns, wherein the pattern geometry and size defined the fate of the NSCs. Lastly, graphene, in combination with nanoparticles was used as component of the ECM to not only enhance the differentiation of NSCs into neurons, but also align the axons of the differentiated NSCs, having significant implications for its use in regenerating injured spinal cords. The final portion of the thesis presents the applications of nanotechnology for developing highly sensitive and selective biosensors, for detecting biomarkers implicated in various diseases such as cancer and acute pancreatitis.

  7. PREFACE: IV Nanotechnology International Forum (RUSNANOTECH 2011)

    Science.gov (United States)

    Dvurechenskii, Anatoly; Alfimov, Mikhail; Suzdalev, Igor; Osiko, Vyacheslav; Khokhlov, Aleksey; Son, Eduard; Skryabin, Konstantin; Petrov, Rem; Deev, Sergey

    2012-02-01

    Logo The RUSNANOTECH 2011 International Forum on Nanotechnology was held from 26-28 October 2011, in Moscow, Russia. It was the fourth forum organized by RUSNANO (Russian Corporation of Nanotechnologies) since 2008. In March 2011 RUSNANO was established as an open joint-stock company through the reorganization of the state corporation Russian Corporation of Nanotechnologies. RUSNANO's mission is to develop the Russian nanotechnology industry through co-investment in nanotechnology projects with substantial economic potential or social benefit. Within the framework of the Forum Science and Technology Program, presentations on key trends of nanotechnology development were given by foreign and Russian scientists, R&D officers of leading international companies, universities and scientific centers. The science and technology program of the Forum was divided into four sections as follows (by following hyperlinks you may find each section's program including videos of all oral presentations): Nanoelectronics and Nanophotonics Nanomaterials Nanotechnology and Green Energy Nanotechnology in Healthcare and Pharma (United business and science & technology section on 'RUSNANOTECH 2011') The scientific program of the forum included more than 50 oral presentations by leading scientists from 15 countries. Among them were world-known specialists such as Professor S Bader (Argonne National Laboratory, USA), Professor O Farokzhad (Harvard Medical School, USA), Professor K Chien (Massachusetts General Hospital, USA), Professor L Liz-Marzan (University of Vigo), A Luque (Polytechnic University of Madrid) and many others. The poster session consisted of over 120 presentations, 90 of which were presented in the framework of the young scientists' nanotechnology papers competition. This volume of Journal of Physics: Conference Series includes a selection of 47 submissions. Section editors of the proceedings: Nanoelectronics and nanophotonics Corresponding Member of Russian Academy of

  8. Nano-technology and nano-toxicology

    OpenAIRE

    Maynard, Robert L.

    2012-01-01

    Rapid developments in nano-technology are likely to confer significant benefits on mankind. But, as with perhaps all new technologies, these benefits are likely to be accompanied by risks, perhaps by new risks. Nano-toxicology is developing in parallel with nano-technology and seeks to define the hazards and risks associated with nano-materials: only when risks have been identified they can be controlled. This article discusses the reasons for concern about the potential effects on health of ...

  9. Application of Nanotechnology in Civil Infrastructure

    OpenAIRE

    Syed Sabihuddin

    2014-01-01

    In this article, use of nanotechnology in building materials on behalf of a range of civil engineering mechanism is discussed. In view of the fact that the use of nanotechnology controls the topic at the minute level, the properties of matter are sincerely affected. Strength, durability and other properties of materials are dramatically affected under a scale of nano meter(10-9m).This article as well reveals how the use of nano technology makes concrete more stronger, durable a...

  10. Identifying nanotechnological linkages in the Finnish economy

    OpenAIRE

    Nikulainen, Tuomo

    2007-01-01

    Nanotechnology, as an emerging science-based technology, is seen to have great potential both in scientific as well as economic terms. In this paper the focus is on identifying the technological linkages between the Finnish nanotechnology community and the industrial incumbents. These technological link-ages are first observed at a broader level in comparison with the technological strengths of the Finnish industries, and then in greater detail at the level of companies. In addition, the abso...

  11. Scientometrics Analysis of Nanotechnology in MEDLINE

    OpenAIRE

    Ali Asgharzadeh; Fatemeh Eskandari; Mohammad-Hossein Biglu

    2011-01-01

    Introduction: Nanotechnology is the study and application of extremely small things and can be used across all the other science fields, such as chemistry, biology, physics, materials science, and engineering. An alternative method for considering the trend of research activities in countries is quantitative analysis of scientific output. The objective of current study is to analyze and visualize the trend of scientific output in the field of nanotechnology in MEDLINE during a period of 10 ye...

  12. Significance of nanotechnology in medical sciences

    OpenAIRE

    Gaur Ajay; Midha Anil; Bhatia Arvind

    2008-01-01

    Nanotechnology refers broadly to a field of applied science and technology whose unifying theme is the control of matter on the molecular level in scales smaller than 1 µm, normally 1-100 nm, and the fabrication of devices within that size range. Two main approaches are used in nanotechnology. In the "bottom-up" approach, materials and devices are built from molecular components, which assemble themselves chemically by principles of molecular recognition. In the "top-down" approach, na...

  13. Nanotechnology An Empty Signifier à venir?

    OpenAIRE

    Wullweber, Joscha

    2008-01-01

    The aim of this article is twofold: First, I would like to theoretically contribute to Science and Technology Studies, and to Science, Technology and Innovation Studies, respectively, by introducing a hegemony- and discourse-theoretical inspired political economy as an interdisciplinary approach. And second, I shall present some tentative empirical analyses of the policy field of nanotechnology. Nanotechnology is widely perceived as the key technology of the 21st century. As a result, it is b...

  14. Nanotechnology and the environment: A European perspective

    OpenAIRE

    D.G. Rickerby et al

    2007-01-01

    The potential positive and negative effects of nanotechnology on the environment are discussed. Advances in nanotechnology may be able to provide more sensitive detection systems for air and water quality monitoring, allowing the simultaneous measurement of multiple parameters and real time response capability. Metal oxide nanocatalysts are being developed for the prevention of pollution due to industrial emissions and the photocatalytic properties of titanium dioxide nanoparticles can be exp...

  15. APPROCHES FOR QUESTION ANSWERING SYSTEMS

    Directory of Open Access Journals (Sweden)

    VANITHA GUDA

    2011-02-01

    Full Text Available Question Answering (QA system is a man machine communication device. The basic idea of QA systems in Natural Language Processing (NLP is to provide correct responses to the questions in a human like manner giving short and accurate answers. This paper presents a survey of various types of QA systems. These QA systems are classified as WEBBASED QA system, Information Retrieval or Information Extraction(IR/IEBASED QA system, RESTRICTED DOMAIN QA (RDQA system and RULE BASED QA system. The paper further investigates a comparative study of these models for different type of questioners which led to a breakthrough for new directions of research in this area.

  16. The handy astronomy answer book

    CERN Document Server

    Liu, PhD, Charles

    2013-01-01

    From planetary movements and the exploration of our solar system to black holes and dark matter, this comprehensive reference simplifies all aspects of astronomy with an approachable question-and-answer format. With chapters broken into various astronomical studies—including the universe, galaxies, planets, and space exploration—this fully updated resource is an ideal companion for students, teachers, and amateur astronomers, answering more than 1,00 questions, such as Is the universe infinite? What would happen to you if you fell onto a black hole? What are the basic concepts of Einstein''s s

  17. Nanotechnology in dentistry: Current achievements and prospects

    Directory of Open Access Journals (Sweden)

    Ramandeep Singh Gambhir

    2013-01-01

    Full Text Available Nanotechnology offers advances particularly in each and every field of human activity such as electronics, industry, telecommunications, environmental science, etc., The field of nanotechnology has got remarkable potential that can bring considerable improvements to the human health, enhanced use of natural resources, and reduced environmental pollution. Since 1990s, nanotechnology has been exploited for potential medical and dental applications. Nanotechnology holds promise for advanced diagnostics, targeted drug delivery, and biosensors. Dentistry is undergoing yet another change to benefit mankind, this time by transforming itself to the nanodentistry. A variety of nanostructures such as nanorobots, nanospheres, nanofibers, nanorods, etc., have been studied for various applications in dentistry and medicine. Preventive dentistry has also utilized nanodentistry to develop the nanomaterials for inclusion in a variety of oral health-care products. However, due to insufficient evidence on potential hazards on human health and environment, nanotechnology has become a controversial issue. It is documented that nanomaterials can enter the human body through several routes and can pose a threat to human health by interacting with the DNA. The present article focuses on the current status and the future implications of nanotechnology in dentistry.

  18. DNA nanotechnology: a future perspective

    Science.gov (United States)

    Zahid, Muniza; Kim, Byeonghoon; Hussain, Rafaqat; Amin, Rashid; Park, Sung Ha

    2013-03-01

    In addition to its genetic function, DNA is one of the most distinct and smart self-assembling nanomaterials. DNA nanotechnology exploits the predictable self-assembly of DNA oligonucleotides to design and assemble innovative and highly discrete nanostructures. Highly ordered DNA motifs are capable of providing an ultra-fine framework for the next generation of nanofabrications. The majority of these applications are based upon the complementarity of DNA base pairing: adenine with thymine, and guanine with cytosine. DNA provides an intelligent route for the creation of nanoarchitectures with programmable and predictable patterns. DNA strands twist along one helix for a number of bases before switching to the other helix by passing through a crossover junction. The association of two crossovers keeps the helices parallel and holds them tightly together, allowing the assembly of bigger structures. Because of the DNA molecule's unique and novel characteristics, it can easily be applied in a vast variety of multidisciplinary research areas like biomedicine, computer science, nano/optoelectronics, and bionanotechnology.

  19. Nanotechnology inspired tools for mitochondrial dysfunction related diseases.

    Science.gov (United States)

    Wen, Ru; Banik, Bhabatosh; Pathak, Rakesh K; Kumar, Anil; Kolishetti, Nagesh; Dhar, Shanta

    2016-04-01

    Mitochondrial dysfunctions are recognized as major factors for various diseases including cancer, cardiovascular diseases, diabetes, neurological disorders, and a group of diseases so called "mitochondrial dysfunction related diseases". One of the major hurdles to gain therapeutic efficiency in diseases where the targets are located in the mitochondria is the accessibility of the targets in this compartmentalized organelle that imposes barriers toward internalization of ions and molecules. Over the time, different tools and techniques were developed to improve therapeutic index for mitochondria acting drugs. Nanotechnology has unfolded as one of the logical and encouraging tools for delivery of therapeutics in controlled and targeted manner simultaneously reducing side effects from drug overdose. Tailor-made nanomedicine based therapeutics can be an excellent tool in the toolbox for diseases associated with mitochondrial dysfunctions. In this review, we present an extensive coverage of possible therapeutic targets in different compartments of mitochondria for cancer, cardiovascular, and mitochondrial dysfunction related diseases. PMID:26776231

  20. 17 CFR 9.23 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 9.23 Section... Appeals § 9.23 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the appeal brief, the exchange must file with the Commission an answering brief. (b) Contents...

  1. Fundamental enabling issues in nanotechnology :

    Energy Technology Data Exchange (ETDEWEB)

    Floro, Jerrold Anthony; Foiles, Stephen Martin; Hearne, Sean Joseph; Hoyt, Jeffrey John; Seel, Steven Craig; Webb, Edmund Blackburn,; Morales, Alfredo Martin; Zimmerman, Jonathan A.

    2007-10-01

    To effectively integrate nanotechnology into functional devices, fundamental aspects of material behavior at the nanometer scale must be understood. Stresses generated during thin film growth strongly influence component lifetime and performance; stress has also been proposed as a mechanism for stabilizing supported nanoscale structures. Yet the intrinsic connections between the evolving morphology of supported nanostructures and stress generation are still a matter of debate. This report presents results from a combined experiment and modeling approach to study stress evolution during thin film growth. Fully atomistic simulations are presented predicting stress generation mechanisms and magnitudes during all growth stages, from island nucleation to coalescence and film thickening. Simulations are validated by electrodeposition growth experiments, which establish the dependence of microstructure and growth stresses on process conditions and deposition geometry. Sandia is one of the few facilities with the resources to combine experiments and modeling/theory in this close a fashion. Experiments predicted an ongoing coalescence process that generates signficant tensile stress. Data from deposition experiments also supports the existence of a kinetically limited compressive stress generation mechanism. Atomistic simulations explored island coalescence and deposition onto surfaces intersected by grain boundary structures to permit investigation of stress evolution during later growth stages, e.g. continual island coalescence and adatom incorporation into grain boundaries. The predictive capabilities of simulation permit direct determination of fundamental processes active in stress generation at the nanometer scale while connecting those processes, via new theory, to continuum models for much larger island and film structures. Our combined experiment and simulation results reveal the necessary materials science to tailor stress, and therefore performance, in

  2. Liposomes and nanotechnology in drug development: focus on oncotargets

    Directory of Open Access Journals (Sweden)

    Kozako T

    2012-09-01

    Full Text Available Tomohiro Kozako,1 Naomichi Arima,2 Makoto Yoshimitsu,3 Shin-Ichro Honda,1 Shinji Soeda11Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan; 2Division of Hematology and Immunology, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan; 3Department of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, JapanAbstract: Nanotechnology is the development of an engineered device at the atomic, molecular, and macromolecular level in the nanometer range. Advances in nanotechnology have proven beneficial in therapeutic fields such as drug-delivery and gene/protein delivery. Antigen delivery systems are important for inducing and modifying immune responses. In cellular immunity, cytotoxic T lymphocytes (CTLs are important in the host defense against tumors. Key to the development of CTL-inducible vaccines is the ability to deliver antigens to antigen-presenting cells efficiently and to induce the subsequent activation of T cell-mediated immunity without adjuvants, as they can induce excessive inflammation leading to systemic febrile disease. Since expression and cloning methods for tumor-associated antigens have been reported, cancer vaccines that induce effective cell immunity may be promising therapeutic candidates, but Th2 cells are undesirable for use in cancer immunotherapy. Peptide vaccines have immunological and economic advantages as cancer vaccines because CTL epitope peptides from tumor-associated antigens have high antigen-specificity. However, cancer vaccines have had limited effectiveness in clinical responses due to the ability of cancer cells to “escape” from cancer immunity and a low efficiency of antigen-specific CTL induction due to immunogenic-free synthetic peptides. In contrast, carbohydrate-decorated particles such as carbohydrate-coated liposomes with encapsulated antigens might be more suitable as

  3. Nanotechnology in the 21st century

    International Nuclear Information System (INIS)

    Nanotechnology is the manipulation structures in materials that are smaller than one billionth of a meter in size. Various successful advances in nanotechnology compelled an almost universal interest in the study of nanomaterials worldwide. The diminutive size of nanomaterials that are smaller than or comparable to a virus (20-450 nm), a protein (5-50 nm), or a gene (2nm wide and 10-100 nm long) pave the way to innumerable engineering and manipulations that triggered a multitude of applications in electronics, solar energy, optics, sports, security, food, agriculture, biology, construction, water, and medicine. The structural features and properties of nanomaterials that are in between those of single atoms/molecules and continuous bulk materials with at least one dimension in the nanometer range bring physical, chemical, electronic, and magnetic properties incomparable with any other materials. Various kinds of nanomaterials possess common as well as individual properties or group properties that allow their unique applications. The broad scope of nanotechnology can be thought of as a territory within which a range of disciplines converge, including chemistry, physics, materials science and engineering, medicine, biology, pharmacology, biotechnology, construction, automotive and aviation, microfabrication, systems architecture for computing, and many more. Nanotechnology holds promise to change the way most things have been designed and manufactured, including drugs, vaccines, fertilizers, TV screens, light fixtures, surgery, skin care products, tennis rackets, cars, paints, and objects unimaginable at this point. Advances in nanotechnology holds promise to repair the damage we have done to our environment, capturing carbon out of the air to return it back to the earth, or using it to build light, strong, diamond-like materials that nanotech-enabled human-scale technology will depend on. Nanotechnology is revolutionizing a wide array of consumer products and

  4. Nanotechnology and the environment: A European perspective

    Directory of Open Access Journals (Sweden)

    D.G. Rickerby et al

    2007-01-01

    Full Text Available The potential positive and negative effects of nanotechnology on the environment are discussed. Advances in nanotechnology may be able to provide more sensitive detection systems for air and water quality monitoring, allowing the simultaneous measurement of multiple parameters and real time response capability. Metal oxide nanocatalysts are being developed for the prevention of pollution due to industrial emissions and the photocatalytic properties of titanium dioxide nanoparticles can be exploited to create self-cleaning surfaces that reduce existing pollution. However, while nanotechnology might provide solutions for certain environmental problems, relatively little is known at present about the environmental impact of nanoparticles, though in some cases chemical composition, size and shape have been shown to contribute to toxicological effects. Nanotechnology can assist resource saving through the use of lightweight, high strength materials based on carbon nanotubes and metal oxide frameworks as hydrogen storage materials. Other energy related applications include nanostructured electrode materials for improving the performance of lithium ion batteries and nanoporous silicon and titanium dioxide in advanced photovoltaic cells. It is important to develop an efficient strategy for the recycling and recovery of nanomaterials and methods are needed to assess whether the potential benefits of nanotechnology outweigh the risks. Life cycle analysis will be a useful tool for assessing the true environmental impacts.

  5. Micro- and nanotechnologies in plankton research

    Science.gov (United States)

    Mohammed, Javeed Shaikh

    2015-05-01

    A better understanding of the vast range of plankton and their interactions with the marine environment would allow prediction of their large-scale impact on the marine ecosystem, and provide in-depth knowledge on pollution and climate change. Numerous technologies, especially lab-on-a-chip microsystems, are being used to this end. Marine biofouling is a global issue with significant economic consequences. Ecofriendly polymer nanotechnologies are being developed to combat marine biofouling. Furthermore, nanomaterials hold great potential for bioremediation and biofuel production. Excellent reviews covering focused topics in plankton research exist, with only a handful discussing both micro- and nanotechnologies. This work reviews both micro- and nanotechnologies applied to broad-ranging plankton research topics including flow cytometry, chemotaxis/toxicity assays, biofilm formation, marine antifouling/fouling-release surfaces and coatings, green energy, green nanomaterials, microalgae immobilization, and bioremediation. It is anticipated that developments in plankton research will see engineered exploitation of micro- and nanotechnologies. The current review is therefore intended to promote micro-/nanotechnology researchers to team up with limnologists/oceanographers, and develop novel strategies for understanding and green exploitation of the complex marine ecosystem.

  6. ANSWER: A tapping apex beat

    OpenAIRE

    Nazar LUQMAN

    2012-01-01

    (Refer to page 253)Answer: Mitral valve stenosis (Doming of mitral leaflets)The mitral valve is frequently involved in rheumatic heart disease, which is still prevalent in developing countries. Other valves may also be involved. The incidence of rheumatic heart disease is now less common in developed and developing nations. It is notinfrequently encountered in Brunei Darussalam. The mitral valve is usually affected decades following an episode of rheumatic carditis. With time, the rheumatic h...

  7. Integrating nanotechnology into school education: a review of the literature

    Science.gov (United States)

    Ghattas, Nadira I.; Carver, Jeffrey S.

    2012-11-01

    Background : In this era of rapid technical advancement, there are growing debates around the idea of nanotechnology, which are both timely and controversial. Nanotechnology materials are being utilized in our daily lives in many ways, often without consumer knowledge. Due to the explosion of nanotechnology applications, there is a necessity to update school science curricula by integrating nanotechnology-related concepts that are both relevant and meaningful to students. The integration of nanotechnology in school science curricula comes in response to nanoscientific development and our mission as educators to instill and arouse students' curiosity in learning about both what is and what will be more dominantly occupying the marketplace. Purpose : The purpose of this review was to set a baseline for the current work being conducted in moving nanotechnology-based activities into the school science setting. Design and methods: The review was implemented by searching LexisNexis Academic, EBSCOhost, Academic Search Complete, Education Search Complete as well as Google Scholar using search terms of nanotechnology, nanotechnology in schools, nanotechnology activities, history of nanotechnology, implications of nanotechnology, issues of nanotechnology and related combinations with nanotechnology as a consistent keyword. Returned articles were categorized by thematic content with primary and seminal work being given priority for inclusion. Conclusions : Current literature in the area of nanotechnology integration into school science curricula presented seven key categories of discussion: the origins of nanotechnology, challenges for educational implementation, currently available school activities, current consumer product applications, ethical issues, recommendations for educational policy, and implications of nanotechnology. There is limited availability of school-based activities. There are strong proponents for including nanotechnology in school science curricula

  8. Predicting attitudes toward nanotechnology: The influence of cultural and predispositional values

    Science.gov (United States)

    Shih, Tsung-Jen

    Past experience in dealing with biotechnology has suggested that public opinion plays an important role in determining the prosperity of emerging technologies. A great amount of money and energy, therefore, were invested to understand nanotechnology's impact on the society and the public, in addition to the technical advancement of the technology. However, most studies examining public opinion have focused on personal level factors and have ignored the potential influence of cultural factors. This study addresses this gap by analyzing public opinion in 21 countries, including the US and 20 European countries. Specifically, this study examines the impact of predispositional and cultural values on public support for nanotechnology, with the mediating roles of moral judgment and risk perception accounted for. This study also looks into the dynamics between cultural values and predispositional values; that is, how cultural values may moderate the effects of predispositional values in affecting attitudes toward nanotechnology. The results indicate that people rely on "information shortcuts," such as confidence and religious belief, for decision making. Individual-level factors still play an important role in shaping public attitudes even after country-level factors are controlled. Furthermore, aggregate cultural values provide people with important "mental programs" to interpret nanotechnology. They explain why people in different cultures have different moral and risk perceptions. However, most of the cultural values do not affect public support directly, suggesting that public support is contingent greatly on the core characteristics of nanotechnology, such as its usefulness, risk, and moral acceptability, which, in turn, is influenced by personal beliefs and cultural givens. The results also suggest that people in different cultures respond to survey questions in different manners. People living in cultures emphasizing uncertainty avoidance and individualism are more

  9. Ag nanoparticles sensitize IR-induced killing of cancer cells

    Institute of Scientific and Technical Information of China (English)

    Ruizhi Xu; Jun Ma; Xinchen Sun; Zhongping Chen; Xiaoli Jiang; Zhirui Guo; Lan Huang; Yang Li; Meng Wang; Changling Wang; Jiwei Liu; Xu Fan; Jiayu Gu; Xi Chen; Yu Zhang; Ning Gu

    2009-01-01

    @@ Dear Editor, Nanosized particulate systems combining better can-cer diagnosis with therapeutic effect are being designed based on the merging of nanotechnology with cellular and molecular techniques.

  10. Nutritional and Nanotechnological Modulators of Microglia

    Science.gov (United States)

    Maysinger, Dusica; Zhang, Issan

    2016-01-01

    Microglia are the essential responders to alimentary, pharmacological, and nanotechnological immunomodulators. These neural cells play multiple roles as surveyors, sculptors, and guardians of essential parts of complex neural circuitries. Microglia can play dual roles in the central nervous system; they can be deleterious and/or protective. The immunomodulatory effects of alimentary components, gut microbiota, and nanotechnological products have been investigated in microglia at the single-cell level and in vivo using intravital imaging approaches, and different biochemical assays. This review highlights some of the emerging questions and topics from studies involving alimentation, microbiota, nanotechnological products, and associated problems in this area of research. Some of the advantages and limitations of in vitro and in vivo models used to study the neuromodulatory effects of these factors, as well as the merits and pitfalls of intravital imaging modalities employed are presented. PMID:27471505

  11. Visual framing of nanotechnology in newspapers

    DEFF Research Database (Denmark)

    Nielsen, Kristian Hvidtfelt

    and understand the articles. It is the objective of this survey to find out if the images used in conjunction to articles that in the text body mention nanotechnology support the general message of the article or, in some way, convey other meanings about nanotechnology. Methods The study uses the newspaper...... database InfoMedia to construct a representative sample of newspaper articles referring to nanotechnology. The images found in the sample are coded using an existing analytical framework put forward by Greek science education scholars, Dimopoulos et al. (2003), in their study of visual images in school......Background Images are important in communicating science. Images are central to most scientists interpreting each others results and methods, and images convey meanings about science to the general public. Even as the importance of images is beginning to find appreciation in studies of multimodal...

  12. Corporate social responsibility for nanotechnology oversight.

    Science.gov (United States)

    Kuzma, Jennifer; Kuzhabekova, Aliya

    2011-11-01

    Growing public concern and uncertainties surrounding emerging technologies suggest the need for socially-responsible behavior of companies in the development and implementation of oversight systems for them. In this paper, we argue that corporate social responsibility (CSR) is an important aspect of nanotechnology oversight given the role of trust in shaping public attitudes about nanotechnology and the lack of data about the health and environmental risks of nanoproducts. We argue that CSR is strengthened by the adoption of stakeholder-driven models and attention to moral principles in policies and programs. In this context, we examine drivers of CSR, contextual and leadership factors that influence CSR, and strategies for CSR. To illustrate these concepts, we discuss existing cases of CSR-like behavior in nanotechnology companies, and then provide examples of how companies producing nanomedicines can exhibit morally-driven CSR behavior.

  13. Nanosprings, Another Piece of the Nanotechnology Puzzle

    Science.gov (United States)

    McIlroy, David

    2003-11-01

    Nanotechnology is being touted as the next significant advancement in science and technology. The proposed applications for nanotechnology range from biological sensors to nanorobotics, to name a few. In order to take nanotechnology from the realm of science fiction to reality we need determine what is possible, as dictated by the laws of physics, and what is not. Often times when approaching a new problem we have a tendency to over complicate the problem. Therefore, when developing nanomachines we should start simple. An excellent place to start is with toys. Toys are designed to perform complex functions using the simplest of designs. If we dictate that our toy performs a function or action then energy will be needed, as well as a means for storing energy. The simplest mechanism that satisfies these two requirements is a spring. In this presentation a summary of the efforts to develop nanosprings, springs that are on the order of tens of nanometers, will be presented.

  14. Nutritional and Nanotechnological Modulators of Microglia.

    Science.gov (United States)

    Maysinger, Dusica; Zhang, Issan

    2016-01-01

    Microglia are the essential responders to alimentary, pharmacological, and nanotechnological immunomodulators. These neural cells play multiple roles as surveyors, sculptors, and guardians of essential parts of complex neural circuitries. Microglia can play dual roles in the central nervous system; they can be deleterious and/or protective. The immunomodulatory effects of alimentary components, gut microbiota, and nanotechnological products have been investigated in microglia at the single-cell level and in vivo using intravital imaging approaches, and different biochemical assays. This review highlights some of the emerging questions and topics from studies involving alimentation, microbiota, nanotechnological products, and associated problems in this area of research. Some of the advantages and limitations of in vitro and in vivo models used to study the neuromodulatory effects of these factors, as well as the merits and pitfalls of intravital imaging modalities employed are presented. PMID:27471505

  15. Nano-technology and nano-toxicology

    Directory of Open Access Journals (Sweden)

    Robert L. Maynard

    2012-05-01

    Full Text Available Rapid developments in nano-technology are likely to confer significant benefits on mankind. But, as with perhaps all new technologies, these benefits are likely to be accompanied by risks, perhaps by new risks. Nano-toxicology is developing in parallel with nano-technology and seeks to define the hazards and risks associated with nano-materials: only when risks have been identified they can be controlled. This article discusses the reasons for concern about the potential effects on health of exposure to nano-materials and relates these to the evidence of the effects on health of the ambient aerosol. A number of hypotheses are proposed and the dangers of adopting unsubstantiated hypotheses are stressed. Nano-toxicology presents many challenges and will need substantial financial support if it is to develop at a rate sufficient to cope with developments in nano-technology.

  16. Corporate social responsibility for nanotechnology oversight.

    Science.gov (United States)

    Kuzma, Jennifer; Kuzhabekova, Aliya

    2011-11-01

    Growing public concern and uncertainties surrounding emerging technologies suggest the need for socially-responsible behavior of companies in the development and implementation of oversight systems for them. In this paper, we argue that corporate social responsibility (CSR) is an important aspect of nanotechnology oversight given the role of trust in shaping public attitudes about nanotechnology and the lack of data about the health and environmental risks of nanoproducts. We argue that CSR is strengthened by the adoption of stakeholder-driven models and attention to moral principles in policies and programs. In this context, we examine drivers of CSR, contextual and leadership factors that influence CSR, and strategies for CSR. To illustrate these concepts, we discuss existing cases of CSR-like behavior in nanotechnology companies, and then provide examples of how companies producing nanomedicines can exhibit morally-driven CSR behavior. PMID:21626458

  17. Nanotechnology in dentistry: reduction to practice.

    Science.gov (United States)

    Ure, David; Harris, Jonathan

    2003-01-01

    The speed at which advances are being made in science has catapulted nanotechnology from its theoretical foundations straight into the real world. There are now many examples of commercially available products demonstrating that, in given situations, the technology really does work and that its scope for further application is wide. Healthcare, along with society as a whole, is facing a major revolution in the wake of ongoing technological developments in the field of nanotechnology. Dentistry as an individual healthcare discipline is not exempt, having already been targeted directly with novel 'nano-materials' at the same time as indirectly enjoying the benefits of nano-related advances in the electronics industry through the ongoing computerization of the modern practice. This article examines current practical applications of nanotechnology alongside proposed applications in the future and aims to demonstrate that, as well as a good deal of science fiction, there is some tangible science fact emerging from this novel multi-disciplinary science.

  18. The industrial relevance of nanotechnology and nanomaterial

    International Nuclear Information System (INIS)

    The article consists of four parts: a brief summary of the EU policy for nanotechnology and for Key Enabling Technologies; a general information framework, including definitions, fields of application, on production and market data; a general examination of the actors and of the application areas in Italy; conclusions. Nanotechnology, along with five other Key Enabling Technologies (Kets), have been identified as the engine for industrial growth in Europe within the Horizon 2020 program and other EU initiatives. These technologies promise to have a growing impact on materials, tools and processes through a great variety of industries important to the Italian economy and the European one. Nanotechnology is still largely a phase of research and development and other challenges are still to be solved for their full value. The Innovation and Research Manager are among those challenges, and are critical to their success

  19. The changing face of dentistry: nanotechnology

    Directory of Open Access Journals (Sweden)

    Kanaparthy R

    2011-11-01

    Full Text Available Rosaiah Kanaparthy1, Aruna Kanaparthy2 1Department of Periodontics, 2Conservative Dentistry, Peoples Dental Academy, Bhopal, Madhya Pradesh, India Abstract: The human body comprises molecules; hence, the availability of molecular nanotechnology will permit dramatic progress to address medical problems and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine could develop devices that are able to work inside the human body in order to identify the early presence of a disease, and to identify and quantify toxic molecules and tumor cells, for example. Nanodentistry will make possible the maintenance of comprehensive oral health by employing nanomaterials, including tissue engineering and, ultimately, dental nanorobots. This review is an attempt to highlight the possible applications of nanotechnology and the use of nanomaterials in dentistry. Keywords: nanotechnology, molecule, nanomedicine, nanodentistry, nanorobots

  20. Nanotechnology in dentistry: Present and future.

    Science.gov (United States)

    Bhardwaj, Archana; Bhardwaj, Abhishek; Misuriya, Abhinav; Maroli, Sohani; Manjula, S; Singh, Arvind Kumar

    2014-02-01

    Nanotechnology is the manipulation of matter on the molecular and atomic levels. It has the potential to bring enormous changes into the fields of medicine and dentistry. A day may soon come when nanodentistry will succeed in maintaining near-perfect oral health through the aid of nanorobotics, nanomaterials and biotechnology. However, as with all developments, it may also pose a risk for misuse. Time, economical and technical resources, and human needs will determine the direction this revolutionizing development may take. This article reviews the current status and the potential clinical applications of nanotechnology, nanaomedicine and nanodentistry. How to cite the article: Bhardwaj A, Bhardwaj A, Misuriya A, Maroli S, Manjula S, Singh AK. Nanotechnology in dentistry: Present and future. J Int Oral Health 2013;6(1):121-6.

  1. Applied Nanotechnology for Human Space Exploration

    Science.gov (United States)

    Yowell, Leonard L.

    2007-01-01

    A viewgraph presentation describing nanotechnology for human space exploration is shown. The topics include: 1) NASA's Strategic Vision; 2) Exploration Architecture; 3) Future Exploration Mission Requirements Cannot be met with Conventional Materials; 4) Nanomaterials: Single Wall Carbon Nanotubes; 5) Applied Nanotechnology at JSC: Fundamentals to Applications; 6) Technology Readiness Levels (TRL); 7) Growth, Modeling, Diagnostics and Production; 8) Characterization: Purity, Dispersion and Consistency; 9) Processing; 10) Nanoelectronics: Enabling Technologies; 11) Applications for Human Space Exploration; 12) Exploration Life Support: Atmosphere Revitalization System; 13) Advanced and Exploration Life Support: Regenerable CO2 Removal; 14) Exploration Life Support: Water Recovery; 15) Advanced Life Support: Water Disinfection/Recovery; 16) Power and Energy: Supercapacitors and Fuel Cells; 17) Nanomaterials for EMI Shielding; 18) Active Radiation Dosimeter; 19) Advanced Thermal Protection System (TPS) Repair; 20) Thermal Radiation and Impact Protection (TRIPS); 21) Nanotechnology: Astronaut Health Management; 22) JSC Nanomaterials Group Collaborations.

  2. 2006-2007 Academic training programme: Nanotechnologies

    CERN Document Server

    2007-01-01

    LECTURE SERIES Monday 11 June from 11:00 to 12:00 - Main Auditorium, bldg. 500 Nanotechnologies: a general introduction (1/3) C. Bottani / Nuclear Engineering Department, Polytechnic of Milano, IT After a brief description of what is nanotechnology (a triple definition will be attempted) and of its importance for the society, this first lecture mainly aims at showing how nanoscience makes various nanotechnologies possible. The surprising story of direct imaging and manipulation of atoms (scanning probe microscopies will be the specific subject of the third lecture by Prof. Andrea Li Bassi) is told to naturally introduce the crucial role of quantum confinement and surface defects. The electronic and vibrational properties of nanostructures are then discussed to understand the connection between the deeply modified (with respect to the bulk) quantum spectra and the physico-chemical properties of nanoscopic objects. In this context the concept of superatom (and its generalizations) is stressed. The essential ro...

  3. Nanotechnology in neurology: Genesis, current status, and future prospects.

    Science.gov (United States)

    Ambesh, Paurush; Angeli, Daniel Gregory

    2015-01-01

    Nanotechnology is a promising, novel field of technological development. There is great potential in research and clinical applications for neurological diseases. Here we chronicle the inception of nanotechnology, discuss its integration with neurology, and highlight the challenges in current application. Some of the problems involving practical use of neuronanotechnology are direct biological toxicity, visualization of the nanodevice, and the short life expectancy of nanomachinery. Neuron cell therapy is an upcoming field for the treatment of challenging problems in neurology. Peptide nanofibers based on amphiphilic molecules have been developed that can autoregulate their structure depending on the conditions of the surrounding milieu. Such frameworks are promising for serving as drug delivery systems or communication bridges between damaged neurons. For common disabling diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), recent developments have seen revolutionary nanotech-based novelties, which are discussed here in detail. Bioimaging integrated with nanoneuromedicine has opened up new doors for cancer and infection therapeutics. PMID:26713006

  4. Nanotechnology in neurology: Genesis, current status, and future prospects

    Directory of Open Access Journals (Sweden)

    Paurush Ambesh

    2015-01-01

    Full Text Available Nanotechnology is a promising, novel field of technological development. There is great potential in research and clinical applications for neurological diseases. Here we chronicle the inception of nanotechnology, discuss its integration with neurology, and highlight the challenges in current application. Some of the problems involving practical use of neuronanotechnology are direct biological toxicity, visualization of the nanodevice, and the short life expectancy of nanomachinery. Neuron cell therapy is an upcoming field for the treatment of challenging problems in neurology. Peptide nanofibers based on amphiphilic molecules have been developed that can autoregulate their structure depending on the conditions of the surrounding milieu. Such frameworks are promising for serving as drug delivery systems or communication bridges between damaged neurons. For common disabling diseases such as Alzheimer′s disease (AD, Parkinson′s disease (PD, amyotrophic lateral sclerosis (ALS, and multiple sclerosis (MS, recent developments have seen revolutionary nanotech-based novelties, which are discussed here in detail. Bioimaging integrated with nanoneuromedicine has opened up new doors for cancer and infection therapeutics.

  5. NANOTECHNOLOGY APPLICATIONS IN AGRICULTURE: AN UPDATE

    Directory of Open Access Journals (Sweden)

    Tejpal Dhewa

    2015-06-01

    Full Text Available Although the scientific studies on the applications of nanotechnology in the agriculture are less than a decade old yet the prospects of nanotechnology in this field has been considerable. The rapid developments in the nanosciences have a great impact on agricultural practices and food manufacturing industries. Nanotechnology has an enormous potential to offer smarter, stronger, cost-effective packaging materials, biosensors for the rapid detection of the food pathogens, toxins and other contaminants or food adulterants. It is also plays an important role in developing a new generation of pesticides with the safest carriers, preservation and packaging of food and food additives, strengthening of natural fiber, removal of various contaminants from the soil and water bodies by using functionalized nanoparticles and improving the shelf-life of the vegetables, flowers and fruits. In spite of the above mentioned immense uses, the competency is being exhibited in some of success business models in developing nanotechnology based products. The safety and regulatory concerns of the application of nanotechnology for human beings, environments and ecosystems are required to be debated, particularly in the developing countries. There are few potential points of direct human exposure to nanomaterials along with the Agri-food chains (from the worker to the consumers, and the threat of the possibility of the nanoparticles reaching the non-targeted sites which can also pose health and environment problems. Keeping in mind all the above benefits and risks associated with nanotechnology, an effective risk management strategy should be followed in parallel to the technological developments or advancements. Moreover, a stable governance model system should be adopted during the entire process (from production to consumption of nanomaterials with continuous interactions and involvement of all the stakeholders.

  6. Connecting Acids and Bases with Encapsulation... and Chemistry with Nanotechnology

    Science.gov (United States)

    Criswell, Brett

    2007-01-01

    The features and the development of various new acids and bases activity sets that combines chemistry with nanotechnology are being described. These sets lead to the generation of many nanotechnology-based pharmaceuticals for the treatment of various diseases.

  7. NCL Instrumentation - Nanotechnology Characterization Laboratory

    Science.gov (United States)

    The activities within the NCL represent a formal scientific interaction of three Federal agencies: National Cancer Institute and U.S. Food and Drug Administration (FDA) of the Department of Health and Human Services, and National Institute of Standards and Technology (NIST) of the Department of Commerce.

  8. Assay Cascades - Nanotechnology Characterization Laboratory

    Science.gov (United States)

    The activities within the NCL represent a formal scientific interaction of three Federal agencies: National Cancer Institute and U.S. Food and Drug Administration (FDA) of the Department of Health and Human Services, and National Institute of Standards and Technology (NIST) of the Department of Commerce.

  9. The changing face of dentistry: nanotechnology.

    Science.gov (United States)

    Kanaparthy, Rosaiah; Kanaparthy, Aruna

    2011-01-01

    The human body comprises molecules; hence, the availability of molecular nanotechnology will permit dramatic progress to address medical problems and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine could develop devices that are able to work inside the human body in order to identify the early presence of a disease, and to identify and quantify toxic molecules and tumor cells, for example. Nanodentistry will make possible the maintenance of comprehensive oral health by employing nanomaterials, including tissue engineering and, ultimately, dental nanorobots. This review is an attempt to highlight the possible applications of nanotechnology and the use of nanomaterials in dentistry.

  10. Applied Nanotechnology and Nanoscience in Orthopedic Oncology.

    Science.gov (United States)

    Savvidou, Olga D; Bolia, Ioanna K; Chloros, George D; Goumenos, Stavros D; Sakellariou, Vasileios I; Galanis, Evanthia C; Papagelopoulos, Panayiotis J

    2016-09-01

    Nanomedicine is based on the fact that biological molecules behave similarly to nanomolecules, which have a size of less than 100 nm, and is now affecting most areas of orthopedics. In orthopedic oncology, most of the in vitro and in vivo studies have used osteosarcoma or Ewing sarcoma cell lineages. In this article, tumor imaging and treatment nanotechnology applications, including nanostructure delivery of chemotherapeutic agents, gene therapy, and the role of nano-selenium-coated implants, are outlined. Finally, the potential role of nanotechnology in addressing the challenges of drug and radiotherapy resistance is discussed. [Orthopedics. 2016; 39(5):280-286.]. PMID:27636683

  11. Nanotechnology in medicine and relevance to dermatology: Present concepts

    OpenAIRE

    Basavaraj, K. H.

    2012-01-01

    Nanotechnology and nanomedicine are complementary disciplines aimed at the betterment of human life. Nanotechnology is an emerging branch of science for designing tools and devices of size 1–100 nm, with unique functions at the cellular, atomic and molecular levels. The concept of using nanotechnology in medical research and clinical practice is known as nanomedicine. Today, nanotechnology and nanoscience approaches to particle design and formulations are beginning to expand the market for ma...

  12. NANOTECHNOLOGY IN OUR CENTURY AND ITS EFFECTS ON BUILDING MATERIALS

    OpenAIRE

    PERKER, Z. Sevgen

    2010-01-01

    Nanotechnology is the study and control of matter at dimensions nanometers. Nanotechnology is also design, fabrication and application of nanostructures and nanomaterials. The research on nanotechnology is evolving and expanding very rapidly every discipline of science. One of them is material science. Nanoscale science and technology gives us unique opportunities to develop revolutionary building materials. This study focuses primarily on nanotechnology and its effects on building materials.

  13. Extensions of Answer Set Programming

    OpenAIRE

    Brik, Alex

    2011-01-01

    This work discusses two new extensions of Answer Set Programming (ASP) and a new computational method for solving the following two problems : (1) given a finite propositional logic program P which has a stable model, find a stable model M of P, and (2) given a finite propositional logic program P which has no stable model, find a maximal program P' which is a subset of P which has a stable model and find a stable model M' of P'. The first extension called Preference Set Constraint (PSC) prog...

  14. Energy challenges. A European answer

    Energy Technology Data Exchange (ETDEWEB)

    Berge, Hans ten [EURELECTRIC, Brussels (Belgium)

    2013-02-01

    The European electricity sector is facing four main challenges: a very challenging investment climate, relatively low electricity demand, the continued expansion of electricity from subsidised renewable energy sources, and the unexpected weakness of the EU Emissions Trading System (ETS). EURELECTRIC's answers to these challenges revolve around a more consistent framework with the ETS as the key driver of decarbonisation, the integration of renewables into the market and a less distortive approach to their development, a renewed focus on energy infrastructure as a means of completing the internal energy market, and an improved strategy for RD and D.

  15. National 5 maths with answers

    CERN Document Server

    Alcorn, David

    2013-01-01

    Teach lessons that suit the individual needs of your classroom with this SQA endorsed and flexibly structured resource that provides a suggested approach through all three units. This 'with answers' version textbook completely covers the latest National 5 syllabus. Each chapter includes summaries of key points and worked examples with explanatory notes showing how skills are applied. Section Reviews presented in non-calculator and calculator formats provide students with the opportunity to consolidate skills acquired over a number of chapters. There are plenty of exercises and invaluable exam

  16. The social and economic challenges of nanotechnology

    International Nuclear Information System (INIS)

    Nanotechnology is being heralded as a new technological revolution, one so profound that it will touch all aspects of human society. Some believe that these influences will be overwhelmingly positive, while others see more sinister implications. This report assesses this debate in the light of our current knowledge of nanotechnology. Conceptions of nanotechnology are not always clear or indeed agreed upon. The domain of nanotechnology is defined in terms of a length scale - from one nanometre up to 100 nanometres, called the nanoscale - and by the appearance at these scales of novel physical properties. These derive from the importance at these scales of physical phenomena that are less obvious for larger objects, such as quantum mechanics, strong surface forces and Brownian motion. Nanotechnotogy will produce economic and social impacts on three broad timescales. Current applications are largely the result of incremental advances in already well-established branches of applied science, such as material science and colloid technology. Medium-term applications of nanotechnology will apply principles only now being established in the laboratory to overcome foreseeable barriers to continued technological progress. In the tong term, entirely new applications may emerge. Current applications for nanotechnology are dominated by tools for scientists, and by new materials that are structured on the nanoscale. Such materials are used in cosmetics, health and medicine and in a variety of manufactured goods. The electronics and information technology industries are also a prominent driver for these new technologies. Debate on the social implications of nanotechnotogy has largely focused not on the relatively mundane applications that have arrived so far, but on the longer-term possibilities of radical nanotechnology. This debate anticipates a degree of control over matter on the nanoscale that permits fabrication from a molecular level of virtually any material or structure

  17. The social and economic challenges of nanotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Wood, Stephen; Jones, Richard; Geldart, Alison

    2003-07-01

    Nanotechnology is being heralded as a new technological revolution, one so profound that it will touch all aspects of human society. Some believe that these influences will be overwhelmingly positive, while others see more sinister implications. This report assesses this debate in the light of our current knowledge of nanotechnology. Conceptions of nanotechnology are not always clear or indeed agreed upon. The domain of nanotechnology is defined in terms of a length scale - from one nanometre up to 100 nanometres, called the nanoscale - and by the appearance at these scales of novel physical properties. These derive from the importance at these scales of physical phenomena that are less obvious for larger objects, such as quantum mechanics, strong surface forces and Brownian motion. Nanotechnotogy will produce economic and social impacts on three broad timescales. Current applications are largely the result of incremental advances in already well-established branches of applied science, such as material science and colloid technology. Medium-term applications of nanotechnology will apply principles only now being established in the laboratory to overcome foreseeable barriers to continued technological progress. In the tong term, entirely new applications may emerge. Current applications for nanotechnology are dominated by tools for scientists, and by new materials that are structured on the nanoscale. Such materials are used in cosmetics, health and medicine and in a variety of manufactured goods. The electronics and information technology industries are also a prominent driver for these new technologies. Debate on the social implications of nanotechnotogy has largely focused not on the relatively mundane applications that have arrived so far, but on the longer-term possibilities of radical nanotechnology. This debate anticipates a degree of control over matter on the nanoscale that permits fabrication from a molecular level of virtually any material or structure

  18. Nanotechnology and Public Interest Dialogue: Some International Observations

    Science.gov (United States)

    Bowman, Diana M.; Hodge, Graeme A.

    2007-01-01

    This article examines nanotechnology within the context of the public interest. It notes that though nanotechnology research and development investment totalled US$9.6 billion in 2005, the public presently understands neither the implications nor how it might be best governed. The article maps a range of nanotechnology dialogue activities under…

  19. Russia's Policy and Standing in Nanotechnology

    Science.gov (United States)

    Terekhov, Alexander I.

    2013-01-01

    In this article, I consider the historical stages of development of nanotechnology in Russia as well as the political framework for this. It is shown that early federal nanotechnology programs in Russia date back to the 1990s and that since the mid-2000s, nanotechnology has attracted the increasing attention of government. I characterize the…

  20. Using a Deliberative Exercise to Foster Public Engagement in Nanotechnology

    Science.gov (United States)

    Jones, Angela R.; Anderson, Ashley A.; Yeo, Sara K.; Greenberg, Andrew E.; Brossard, Dominique; Moore, John W.

    2014-01-01

    Nanotechnology is an emerging technology poised to benefit society both technically and socially, but as with any new advance, there is potential risk. This paper describes a novel deliberative exercise involving nanotechnology that engages the public in debate regarding the funding of nanotechnology-related research while also discussing…

  1. Integrating Nanotechnology into School Education: A Review of the Literature

    Science.gov (United States)

    Ghattas, Nadira I.; Carver, Jeffrey S.

    2012-01-01

    Background: In this era of rapid technical advancement, there are growing debates around the idea of nanotechnology, which are both timely and controversial. Nanotechnology materials are being utilized in our daily lives in many ways, often without consumer knowledge. Due to the explosion of nanotechnology applications, there is a necessity to…

  2. Effect of Nanotechnology Instructions on Senior High School Students

    Science.gov (United States)

    Lu, Chow-Chin; Sung, Chia-Chi

    2011-01-01

    In this research, we cooperate with senior high school teachers to understand current nanotechnology model of senior high school nanotechnology curriculum in Taiwan. Then design senior high school nanotechnology (nano-tech) curriculum to teach 503 senior high school students. After teaching the nano-tech curriculum we use the "Nanotechnology…

  3. 5th International Symposium on Nanotechnology in Construction

    CERN Document Server

    Shah, Surendra

    2015-01-01

    Nanotechnology has already demonstrated surprising potential for improving the performance of construction materials, and many of these recent developments were facilitated by NICOM symposia. The NICOM5 proceedings will cover the emerging opportunities and future use of nanotechnology in construction, and will illustrate the broad potential for application of nanotechnology to challenging problems involving materials and infrastructure.

  4. Nanotechnology, Big things from a Tiny World: a Review

    Directory of Open Access Journals (Sweden)

    Debnath Bhattacharyya

    2009-09-01

    Full Text Available The purpose of this paper is to look into the present aspects of “Nanotechnology”. This paper gives a brief description of what Nanotechnology is?? And its application in various fields viz. computing, medicine, food technology, Robotics, Solar cells etc. It also deals with the future perspectives of Nanotechnology, risks in advanced nanotechnology.

  5. Nanotechnology, Big things from a Tiny World: a Review

    OpenAIRE

    Debnath Bhattacharyya; Shashank Singh; Niraj Satnalika; Ankesh Khandelwal; Seung-Hwan Jeon

    2009-01-01

    The purpose of this paper is to look into the present aspects of “Nanotechnology”. This paper gives a brief description of what Nanotechnology is?? And its application in various fields viz. computing, medicine, food technology, Robotics, Solar cells etc. It also deals with the future perspectives of Nanotechnology, risks in advanced nanotechnology.

  6. Military Applications of Nanotechnology: Implications for Strategic Cooperation & Conflict

    OpenAIRE

    Center on Contemporary Conflict

    2012-01-01

    FY 2012-2013. Project Leads: Kosal, Margaret E. The report will advance critical thinking on the potential role and impact of nanotechnology on defense policy. It will view nanotechnology through the prism of international cooperation and competition, examining whether emerging nanotechnology will exacerbate or mitigate regional security challenges. NA

  7. An intelligent approach to nanotechnology

    Science.gov (United States)

    Demming, Anna

    2013-11-01

    Control counts for little without a guiding principle. Whether manipulating atoms with a scanning probe or controlling carrier concentration in thin film deposition, intelligent intervention is required to steer the process from aimless precision towards a finely optimized design. In this issue G M Sacha and P Varona describe how artificial intelligence approaches can help towards modelling and simulating nanosystems, increasing our grasp of the nuances of these systems and how to optimize them for specific applications [1]. More than a labour-saving technique their review also suggests how genetic algorithms and artificial neural networks can supersede existing capabilities to tackle some of the challenges in moving a range of nanotechnologies forward. Research has made giant strides in determining not just what system parameters enhance performance but how. Nanoparticle synthesis is a typical example, where the field has shifted from simple synthesis and observation to unearthing insights as to dominating factors that can be identified and enlisted to control the morphological and chemical properties of synthesized products. One example is the neat study on reaction media viscosity for silver nanocrystal synthesis, where Park, Im and Park in Korea demonstrated a level of size control that had previously proved hard to achieve [2]. Silver nanoparticles have many potential applications including catalysis [3], sensing [4] and surface enhanced Raman scattering [5]. In their study, Park and colleagues obtain size-controlled 30 nm silver nanocrystals in a viscosity controlled medium of 1,5-pentanediol and demonstrate their use as sacrificial cores for the fabrication of a low-refractive filler. Another nanomaterial that has barely seen an ebb in research activity over the past two decades is ZnO, with a legion of reports detailing how to produce ZnO in different nanoscale forms from rods [6], belts [7] and flowers [8] to highly ordered arrays of vertically aligned

  8. Limits between molecular biology and nanotechnology: impact on medicine La frontera entre la Biología molecular y la Nanotecnología: impacto en la Medicina

    OpenAIRE

    Ciro Alfonso Casadiego Torrado; Ananías García Cardona; Astrid Ruiz; Ómar Mejía Mejía; Grégory Alfonso García Morán; Dianney Clavijo Grimaldi; Mario Vittorino Mejía

    2007-01-01

    With the advent of Nanotechnology, the prospects have rapidly improved for using nanomaterials in medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas. Nanomedicine is the application of nanotechnologies to the maintenance and improvement of human life. Nanosystems (nanoliposomes, quantum dots, nanoparticles, dendrimers) have a vast potential in these areas, and novel applications are being actively explored. Con el advenimiento de la Nanobiotecno...

  9. RHETORICAL STRUCTURE OF ARGUMENTATIVE ANSWER

    Directory of Open Access Journals (Sweden)

    Juliano Desiderato ANTONIO

    2014-12-01

    Full Text Available The aim of this paper is to describe the rhetorical structure of the argumentative answer genre in a corpus formed by 15 compositions of the winter vestibular of Universidade Estadual de Maringá. The instrument of analysis used in the investigation was RST (Rhetorical Structure Theory. The initial statement was considered the central unit of the argumentative answer. Most of the writers held evidence relation between the central unit (nucleus and the expansion (satellite. Evidence relation is interpersonal and the aim of the writers is to convince their addressees (in this case the compositions evaluation committee that their point is correct. Within the initial statement, the relation with higher frequency was contrast. Our hypothesis is that the selection of texts of the test influenced the applicants to present positive and negative aspects of the internet. In the higher level of the expansion text span, list is the most frequent relation because the applicants present various arguments with the same status. Contrast was the second relation with highest frequency in this same level. Our hypothesis is that the selection of texts of the test influenced the applicants to present positive and negative aspects of the internet as it happened in the initial statement. Within the 15 compositions, 12 had a conclusion. This part was considered a satellite of the span formed by the initial statement and its expansion. The relation held was homonymous.

  10. Influence of nanotechnology on herbal drugs: A Review

    Directory of Open Access Journals (Sweden)

    S H Ansari

    2012-01-01

    Full Text Available Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared with modern medicines. Phytotherapeutics need a scientific approach to deliver the components in a sustained manner to increase patient compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems (NDDS for herbal constituents. NDDSs not only reduce the repeated administration to overcome non-compliance, but also help to increase the therapeutic value by reducing toxicity and increasing the bioavailability. One such novel approach is nanotechnology. Nano-sized drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines . Hence, integration of the nanocarriers as a NDDS in the traditional medicine system is essential to conflict more chronic diseases like asthma, diabetes, cancer, and others.

  11. Evaluating Multilingual Question Answering Systems at CLEF

    OpenAIRE

    Forner, Pamela; Giampiccolo, Danilo; Magnini, Bernardo; Peñas, Anselmo; Rodrigo, Álvaro; Sutcliffe, Richard

    2010-01-01

    The paper offers an overview of the key issues raised during the seven years’ activity of the Multilingual Question Answering Track at the Cross Language Evaluation Forum (CLEF). The general aim of the Multilingual Question Answering Track has been to

  12. Climate Change Facts: Answers to Common Questions

    Science.gov (United States)

    ... Basics Climate Change Facts: Answers to Common Questions Climate Change Facts: Answers to Common Questions This page ... All Responses Is there a scientific consensus on climate change? The major scientific agencies of the United ...

  13. Importance of Nanotechnology in Civil Engineering

    Directory of Open Access Journals (Sweden)

    Kaizar Hossain

    2015-02-01

    Full Text Available Nanotechnology is an extremely wide term, the definition of which varies from field to field. Most commonly, nanotechnology is defined as “…the understanding, control, and restructuring of matter on the order of nanometers (i.e., less than 100 nm to create materials with fundamentally new properties and functions” [1]. Nanotechnology refers to the manipulation of individual atoms and molecules, by engineering matter at the atomic level.  At the nanoscale, familiar materials can have dramatically different properties: changes can affect color, elasticity, strength, conductivity, and other properties. Nanoparticles also have an increased surface area relative to their volume, making them especially reactive and useful in energy storage, for making composite materials, or as drug delivery devices. Nano materials are also able to be integrated with biological materials, producing new structures that have properties of both types of materials. There are two main types of approaches to nanotechnology: The “top-down” approach and the “bottom-up” approach. The “top-down” approach involves taking larger structures that are either reduced down in size until they reach the nano-scale, or are deconstructed into their composite parts. On the other hand, the “bottom-up” approach is where materials are constructed from the atomic or molecular components.Key Words: materials, structures, nanoparticles, Titanium dioxide,

  14. Nanotechnology for sustainable development: retrospective and outlook

    International Nuclear Information System (INIS)

    The world is facing great challenges in meeting rising demands for basic commodities (e.g., food, water and energy), finished goods (e.g., cell phones, cars and airplanes) and services (e.g., shelter, healthcare and employment) while reducing and minimizing the impact of human activities on Earth’s global environment and climate. Nanotechnology has emerged as a versatile platform that could provide efficient, cost-effective and environmentally acceptable solutions to the global sustainability challenges facing society. This special issue of the Journal of Nanoparticle Research is devoted to the utilization of nanotechnology to improve or achieve sustainable development. We highlight recent advances and discuss opportunities of utilizing nanotechnology to address global challenges in (1) water purification, (2) clean energy technologies, (3) greenhouse gases management, (4) materials supply and utilization, and (5) green manufacturing and chemistry. In addition to the technical challenges listed above, we also discuss societal perspectives and provide an outlook of the role of nanotechnology in the convergence of knowledge, technology and society for achieving sustainable development

  15. Pharmacogenomics and Nanotechnology Toward Advancing Personalized Medicine

    Science.gov (United States)

    Vizirianakis, Ioannis S.; Amanatiadou, Elsa P.

    The target of personalized medicine to achieve major benefits for all patients in terms of diagnosis and drug delivery can be facilitated by creating a sincere multidisciplinary information-based infrastructure in health care. To this end, nanotechnology, pharmacogenomics, and informatics can advance the utility of personalized medicine, enable clinical translation of genomic knowledge, empower healthcare environment, and finally improve clinical outcomes.

  16. Make Sense of Nanochemistry and Nanotechnology

    Science.gov (United States)

    Ambrogi, Paola; Caselli, Monica; Montalti, Marco; Venturi, Margherita

    2008-01-01

    A class in a Scientific-Technological Lyceum (age 17) decided to produce a PowerPoint presentation to introduce nanochemistry and nanotechnology to the students in lower grades. Because the subject is very new, there was nothing in the School textbooks and, therefore, the students had to cooperate in order to find materials, to use ICT sources and…

  17. Nanoscience and Nanotechnology for the Middle Years

    Science.gov (United States)

    Ng, Wan

    2009-01-01

    Capturing students' interest in science at the junior levels is crucial to not only improving the uptake of science at senior levels but to promoting science literacy in all students in order to prepare them for a society that is very science and technologically driven. This paper presents nanotechnology as an emerging science that is both factual…

  18. Surfaces in Precision Engineering, Microengineering and Nanotechnology

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo; Kunzmann, H.; Peggs, G. N.;

    2003-01-01

    with precision engineering, microengineering and nanotechnology are presented, encompassing surfaces in computers, MEMS, biomedical systems, light and X-ray optics, as well as in chemical systems. Surface properties at micro and nanoscale are considered, including geometry as well as physical and chemical...

  19. Nanotechnology in cosmetics: Opportunities and challenges.

    Science.gov (United States)

    Raj, Silpa; Jose, Shoma; Sumod, U S; Sabitha, M

    2012-07-01

    Nanotechnology is the science of manipulating atoms and molecules in the nanoscale - 80,000 times smaller than the width of a human hair. The world market for products that contain nanomaterials is expected to reach $2.6 trillion by 2015. The use of nanotechnology has stretched across various streams of science, from electronics to medicine and has now found applications in the field of cosmetics by taking the name of nanocosmetics. This widespread influence of nanotechnology in the cosmetic industries is due to the enhanced properties attained by the particles at the nano level including color, transparency, solubility etc. The different types of nanomaterials employed in cosmetics include nanosomes, liposomes, fullerenes, solid lipid nanoparticles etc. Recently, concerns over the safety of such nanocosmetics are raised and have forced the cosmetic industries to limit the use of nanotechnology in cosmetics and for enforcing laws to undergo a full-fledged safety assessment before they enter into the market. In this review, emphasis is made on the types of nanomaterials used in cosmetics by the various cosmetic brands, the potential risks caused by them both to human life and also to the environment and what all regulations have been undertaken or can be taken to overcome them.

  20. Nanotechnology in cosmetics: Opportunities and challenges

    Directory of Open Access Journals (Sweden)

    Silpa Raj

    2012-01-01

    Full Text Available Nanotechnology is the science of manipulating atoms and molecules in the nanoscale - 80,000 times smaller than the width of a human hair. The world market for products that contain nanomaterials is expected to reach $2.6 trillion by 2015. The use of nanotechnology has stretched across various streams of science, from electronics to medicine and has now found applications in the field of cosmetics by taking the name of nanocosmetics. This widespread influence of nanotechnology in the cosmetic industries is due to the enhanced properties attained by the particles at the nano level including color, transparency, solubility etc. The different types of nanomaterials employed in cosmetics include nanosomes, liposomes, fullerenes, solid lipid nanoparticles etc. Recently, concerns over the safety of such nanocosmetics are raised and have forced the cosmetic industries to limit the use of nanotechnology in cosmetics and for enforcing laws to undergo a full-fledged safety assessment before they enter into the market. In this review, emphasis is made on the types of nanomaterials used in cosmetics by the various cosmetic brands, the potential risks caused by them both to human life and also to the environment and what all regulations have been undertaken or can be taken to overcome them.

  1. Nanotechnology for sustainable development: retrospective and outlook

    Energy Technology Data Exchange (ETDEWEB)

    Diallo, Mamadou S., E-mail: mdiallo@kaist.ac.kr [Korea Advanced Institute of Science and Technology (KAIST), Graduate School of Energy, Environment, Water and Sustainability (EEWS) (Korea, Republic of); Fromer, Neil A. [California Institute of Technology, Resnick Sustainability Institute (United States); Jhon, Myung S. [Carnegie Mellon University, Department of Chemical Engineering (United States)

    2013-11-15

    The world is facing great challenges in meeting rising demands for basic commodities (e.g., food, water and energy), finished goods (e.g., cell phones, cars and airplanes) and services (e.g., shelter, healthcare and employment) while reducing and minimizing the impact of human activities on Earth’s global environment and climate. Nanotechnology has emerged as a versatile platform that could provide efficient, cost-effective and environmentally acceptable solutions to the global sustainability challenges facing society. This special issue of the Journal of Nanoparticle Research is devoted to the utilization of nanotechnology to improve or achieve sustainable development. We highlight recent advances and discuss opportunities of utilizing nanotechnology to address global challenges in (1) water purification, (2) clean energy technologies, (3) greenhouse gases management, (4) materials supply and utilization, and (5) green manufacturing and chemistry. In addition to the technical challenges listed above, we also discuss societal perspectives and provide an outlook of the role of nanotechnology in the convergence of knowledge, technology and society for achieving sustainable development.

  2. Innovations in nanotechnology for water treatment

    Directory of Open Access Journals (Sweden)

    Gehrke I

    2015-01-01

    Full Text Available Ilka Gehrke, Andreas Geiser, Annette Somborn-SchulzFraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT, Oberhausen, GermanyAbstract: Important challenges in the global water situation, mainly resulting from worldwide population growth and climate change, require novel innovative water technologies in order to ensure a supply of drinking water and reduce global water pollution. Against this background, the adaptation of highly advanced nanotechnology to traditional process engineering offers new opportunities in technological developments for advanced water and wastewater technology processes. Here, an overview of recent advances in nanotechnologies for water and wastewater treatment processes is provided, including nanobased materials, such as nanoadsorbents, nanometals, nanomembranes, and photocatalysts. The beneficial properties of these materials as well as technical barriers when compared with conventional processes are reported. The state of commercialization is presented and an outlook on further research opportunities is given for each type of nanobased material and process. In addition to the promising technological enhancements, the limitations of nanotechnology for water applications, such as laws and regulations as well as potential health risks, are summarized. The legal framework according to nanoengineered materials and processes that are used for water and wastewater treatment is considered for European countries and for the USA.Keywords: nanotechnology, water technology, nanoadsorbents, nanometals, nanomembranes, photocatalysis

  3. Interdisciplinarity in Biotechnology, Genomics and Nanotechnology

    NARCIS (Netherlands)

    Heimeriks, G.J.

    2013-01-01

    In this paper we study developments in biotechnology, genomics and nanotechnology in the period 1998–2008. The fields show changing interdisciplinary characteristics in relation to distinct co-evolutionary dynamics in research, science and society. Biotechnology emerged as a discipline in publicatio

  4. Articulation: how societal goals matter in nanotechnology

    NARCIS (Netherlands)

    Bos, C.

    2016-01-01

    Science policies try to steer scientists to conduct societally relevant research. This societal relevance is often expressed in large societal goals, such as addressing sustainability or helping with the problems that an ageing society might bring. Emerging technologies, like nanotechnology, are oft

  5. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  6. Enhancing nanopore sensing with DNA nanotechnology

    Science.gov (United States)

    Keyser, Ulrich F.

    2016-02-01

    Nanopores are on the brink of fundamentally changing DNA sequencing. At the same time, DNA origami provides unprecedented freedom in molecular design. Here, I suggest why a combination of solid-state nanopores and DNA nanotechnology will lead to exciting new experiments.

  7. Nanotechnology and Nanoscale Science: Educational challenges

    Science.gov (United States)

    Jones, M. Gail; Blonder, Ron; Gardner, Grant E.; Albe, Virginie; Falvo, Michael; Chevrier, Joel

    2013-06-01

    Nanotechnology has been touted as the next 'industrial revolution' of our modern age. In order for successful research, development, and social discourses to take place in this field, education research is needed to inform the development of standards, course development, and workforce preparation. In addition, there is a growing need to educate citizens and students about risks, benefits, and social and ethical issues related to nanotechnology. This position paper describes the advancements that have been made in nanoscale science and nanotechnology, and the challenges that exist to educate students and the public about critical nanoscience concepts. This paper reviews the current research on nanotechnology education including curricula, educational programs, informal education, and teacher education. Furthermore, the unique risks, benefits and ethics of these unusual technological applications are described in relation to nanoeducation goals. Finally, we outline needed future research in the areas of nanoscience content, standards and curricula, nanoscience pedagogy, teacher education, and the risks, benefits, and social and ethical dimensions for education in this emerging field.

  8. 24 CFR 1720.610 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Answering brief. 1720.610 Section... Proceedings Appeals § 1720.610 Answering brief. Within 20 days after service of an appeal brief upon a party, such party may file an answering brief conforming to the requirements of § 1720.620....

  9. 17 CFR 171.26 - Answering brief.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answering brief. 171.26... Denial and Registration Actions § 171.26 Answering brief. (a) Time for filing answering brief. Within thirty days after service of the apeal brief, the National Futures Association shall file with...

  10. 5 CFR 185.109 - Answer.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Answer. 185.109 Section 185.109 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.109 Answer. (a) The defendant may request a hearing in the answer filed with the...

  11. Cooperative answering and Inferential Erotetic Logic

    OpenAIRE

    Łupkowski, Paweł

    2010-01-01

    This paper addresses the issue of applicability of erotetic search scenarios, a tool developed within Inferential Erotetic Logic, in the area of cooperative answering for databases and information systems. Short descriptions of cooperative answering and Erotetic Search Scenarios are given. Some basic cooperative answering phenomena are modeled within the framework of Erotetic Search Scenarios.

  12. Nanotechnology for Data Storage Applications

    Science.gov (United States)

    Sarid, Dror; McCarthy, Brendan; Jabbour, Ghassan

    This chapter considers atomic force microscopy (AFM) as an enabling technology for data storage applications, considering already existing technologies such as hard disk drives (HDD), optical disk drives (ODD) and flash memories that currently dominate the nonvolatile data storage market, together with future devices based on magnetoresistive and phase change effects. The issue at hand is the question of whether the novel AFM-based storage, dubbed probe storage, can offer a competing approach to the currently available technologies by playing the role of a disruptive technology. Probe storage will be contrasted to HDD and ODD, which are purely mechanical as they are based on a rotating disk that uses just a single probe to address billions of bits of data, and nonvolatile random-access memory (RAM) that has no moving parts yet requires billions of interconnects. In particular, capacity, areal density, transfer rate, form factor and the cost of various data storage devices will be discussed and the unique opportunity offered by probe storage in employing massive parallelism will be outlined. It will be shown that probe storage bridges the gap between HDD, ODD and other nonvolatile RAM, drawing from the strength of each one of these and adding a significant attribute neither of these has; namely, the possibility of addressing a very large number of nanoscale bits of data in parallel. This chapter differs from the other chapters in this book in that it addresses the important issue of whether a given scientific effort, namely, probe storage, is mature enough to evolve into a commercially viable technology. The answer seems to indicate that there is indeed a huge niche in the data storage arena that such a technology is uniquely qualified to fill, which is large enough to justify a major investment in research and development. Indeed, as other chapters indicate, such an effort is developing at a rapid pace, with hopes of having a viable product within a few years.

  13. The structure and infrastructure of the global nanotechnology literature

    International Nuclear Information System (INIS)

    Text mining is the extraction of useful information from large volumes of text. A text mining analysis of the global open nanotechnology literature was performed. Records from the Science Citation Index (SCI)/Social SCI were analyzed to provide the infrastructure of the global nanotechnology literature (prolific authors/journals/institutions/countries, most cited authors/papers/journals) and the thematic structure (taxonomy) of the global nanotechnology literature, from a science perspective. Records from the Engineering Compendex (EC) were analyzed to provide a taxonomy from a technology perspective.The Far Eastern countries have expanded nanotechnology publication output dramatically in the past decade.The Peoples Republic of China ranks second to the USA (2004 results) in nanotechnology papers published in the SCI, and has increased its nanotechnology publication output by a factor of 21 in a decade.Of the six most prolific (publications) nanotechnology countries, the three from the Western group (USA, Germany, France) have about eight percent more nanotechnology publications (for 2004) than the three from the Far Eastern group (China, Japan, South Korea).While most of the high nanotechnology publication-producing countries are also high nanotechnology patent producers in the US Patent Office (as of 2003), China is a major exception. China ranks 20th as a nanotechnology patent-producing country in the US Patent Office

  14. The structure and infrastructure of the global nanotechnology literature

    Energy Technology Data Exchange (ETDEWEB)

    Kostoff, Ronald N., E-mail: kostofr@onr.navy.mil; Stump, Jesse A. [Office of Naval Research (United States); Johnson, Dustin [Northrop Grumman TASC (United States); Murday, James S. [Naval Research Laboratory, Chemistry Division, Code 6100 (United States); Lau, Clifford G.Y. [Institute for Defense Analyses (United States); Tolles, William M

    2006-08-15

    Text mining is the extraction of useful information from large volumes of text. A text mining analysis of the global open nanotechnology literature was performed. Records from the Science Citation Index (SCI)/Social SCI were analyzed to provide the infrastructure of the global nanotechnology literature (prolific authors/journals/institutions/countries, most cited authors/papers/journals) and the thematic structure (taxonomy) of the global nanotechnology literature, from a science perspective. Records from the Engineering Compendex (EC) were analyzed to provide a taxonomy from a technology perspective.The Far Eastern countries have expanded nanotechnology publication output dramatically in the past decade.The Peoples Republic of China ranks second to the USA (2004 results) in nanotechnology papers published in the SCI, and has increased its nanotechnology publication output by a factor of 21 in a decade.Of the six most prolific (publications) nanotechnology countries, the three from the Western group (USA, Germany, France) have about eight percent more nanotechnology publications (for 2004) than the three from the Far Eastern group (China, Japan, South Korea).While most of the high nanotechnology publication-producing countries are also high nanotechnology patent producers in the US Patent Office (as of 2003), China is a major exception. China ranks 20th as a nanotechnology patent-producing country in the US Patent Office.

  15. Factors affecting the perceptions of Iranian agricultural researchers towards nanotechnology.

    Science.gov (United States)

    Hosseini, Seyed Mahmood; Rezaei, Rohollah

    2011-07-01

    This descriptive survey research was undertaken to design appropriate programs for the creation of a positive perception of nanotechnology among their intended beneficiaries. In order to do that, the factors affecting positive perceptions were defined. A stratified random sample of 278 science board members was selected out of 984 researchers who were working in 22 National Agricultural Research Institutions (NARIs). Data were collected by using a mailed questionnaire. The descriptive results revealed that more than half of the respondents had "low" or "very low" familiarity with nanotechnology. Regression analysis indicated that the perceptions of Iranian NARI Science Board Members towards nanotechnology were explained by three variables: the level of their familiarity with emerging applications of nanotechnology in agriculture, the level of their familiarity with nanotechnology and their work experiences. The findings of this study can contribute to a better understanding of the present situation of the development of nanotechnology and the planning of appropriate programs for creating a positive perception of nanotechnology.

  16. Managing risk in nanotechnology topics in governance, assurance and transfer

    CERN Document Server

    McAlea, Eamonn; Mullins, Martin

    2016-01-01

    This book aims to address how nanotechnology risks are being addressed by scientists, particularly in the areas of human health and the environment and how these risks can be measured in financial terms for insurers and regulators. It provides a comprehensive overview of nanotechnology risk measurement and risk transfer methods, including a chapter outlining how Bayesian methods can be used. It also examines nanotechnology from a legal perspective, both current and potential future outcomes. The global market for nanotechnology products was valued at $22.9 billion in 2013 and increased to about $26 billion in 2014. This market is expected to reach about $64.2 billion by 2019, a compound annual growth rate (CAGR) of 19.8% from 2014 to 2019. Despite the increasing value of nanotechnologies and their widespread use, there is a significant gap between the enthusiasm of scientists and nanotechnology entrepreneurs working in the nanotechnology space and the insurance/regulatory sector. Scientists are scarcely aware...

  17. Control Banding and Nanotechnology Synergist

    Energy Technology Data Exchange (ETDEWEB)

    Zalk, D; Paik, S

    2009-12-15

    uncertainty, that attracted international NM experts to recommend this qualitative risk assessment approach for NM. However, since their CB recommendation was only in theory, we took on the challenge of developing a working toolkit, the CB Nanotool (see Zalk et al. 2009 and Paik et al. 2008), as a means to perform a risk assessment and protect researchers at the Lawrence Livermore National Laboratory. While it's been acknowledged that engineered NM have potentially endless benefits for society, it became clear to us that the very properties that make nanotechnology so useful to industry could also make them dangerous to humans and the environment. Among the uncertainties and unknowns with NM are: the contribution of their physical structure to their toxicity, significant differences in their deposition and clearance in the lungs when compared to their parent material (PM), a lack of agreement on the appropriate indices for exposure to NM, and very little background information on exposure scenarios or populations at risk. Part of this lack of background information can be traced to the lack of risk assessments historically performed in the industry, with a recent survey indicating that 65% of companies working with NM are not doing any kind of NM-specific risk assessment as they focus on traditional PM methods for IH (Helland et al. 2009). The good news is that the amount of peer-reviewed publications that address environmental, health and safety aspects of NM has been increasing over the last few years; however, the percentage of these that address practical methods to reduce exposure and protect workers is orders of magnitude lower. Our intent in developing the CB Nanotool was to create a simplified approach that would protect workers while unraveling the mysteries of NM for experts and non-experts alike. Since such a large part of the toxicological effects of both the physical and chemical properties of NM were unknown, not to mention changing logarithmically as new

  18. PREFACE: TNT 2004: Trends in Nanotechnology

    Science.gov (United States)

    Correia, Antonio; Serena, Pedro A.; Saenz, Juan Jose; Welland, Mark; Reifenberger, Ron

    2005-05-01

    This special issue of Nanotechnology presents representative contributions describing the main topics covered at the fifth `Trends in Nanotechnology' (TNT2004) international conference, held in Segovia, Spain, 13-17 September 2004. During the past few years many international or regional conferences have emerged in response to the growing awareness of the importance of nanotechnology as a key issue for the future of scientific and technological development. Among these, the conference series `Trends in Nanotechnology' (Toledo, Spain, 2000; Segovia, Spain, 2001; Santiago de Compostela, Spain, 2002; Salamanca, Spain, 2003; and Segovia, Spain, 2004) has become one of the most important meeting points in the nanotechnology field: it provides fresh ideas, brings together well-known speakers, and promotes a suitable environment for discussions, exchanging ideas, and enhancing scientific and personal relations among participants. TNT2004 was organized in a similar way to the four previous TNT conferences, with an impressive scientific programme, without parallel sessions, covering a wide spectrum of nanotechnology research. In 2004, more than 370 scientists worldwide attended this event and contributed more than 80 talks, 236 posters, and stimulating discussions about their most recent research. The aim of the conference was to focus on the applications of nanotechnology and to bring together, in a scientific forum, various worldwide groups belonging to industry, universities and government institutions. TNT2004 was particularly effective at transmitting information and establishing contacts among workers in this field. Graduate students attending such conferences understand the importance of interdisciplinary skills in facilitating their future lines of research. Sixty-four graduate students received a grant (from NASA, ONRIFO, IRC, iNANO, SME, NSERC/CRSNG, EU PHANTOMS Network or TNT) allowing them to present their work. During this event, 22 prizes for the best posters

  19. Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

    Directory of Open Access Journals (Sweden)

    Marina E. Vance

    2015-08-01

    Full Text Available To document the marketing and distribution of nano-enabled products into the commercial marketplace, the Woodrow Wilson International Center for Scholars and the Project on Emerging Nanotechnologies created the Nanotechnology Consumer Products Inventory (CPI in 2005. The objective of this present work is to redevelop the CPI by leading a research effort to increase the usefulness and reliability of this inventory. We created eight new descriptors for consumer products, including information pertaining to the nanomaterials contained in each product. The project was motivated by the recognition that a diverse group of stakeholders from academia, industry, and state/federal government had become highly dependent on the inventory as an important resource and bellweather of the pervasiveness of nanotechnology in society. We interviewed 68 nanotechnology experts to assess key information needs. Their answers guided inventory modifications by providing a clear conceptual framework best suited for user expectations. The revised inventory was released in October 2013. It currently lists 1814 consumer products from 622 companies in 32 countries. The Health and Fitness category contains the most products (762, or 42% of the total. Silver is the most frequently used nanomaterial (435 products, or 24%; however, 49% of the products (889 included in the CPI do not provide the composition of the nanomaterial used in them. About 29% of the CPI (528 products contain nanomaterials suspended in a variety of liquid media and dermal contact is the most likely exposure scenario from their use. The majority (1288 products, or 71% of the products do not present enough supporting information to corroborate the claim that nanomaterials are used. The modified CPI has enabled crowdsourcing capabilities, which allow users to suggest edits to any entry and permits researchers to upload new findings ranging from human and environmental exposure data to complete life cycle

  20. Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory.

    Science.gov (United States)

    Vance, Marina E; Kuiken, Todd; Vejerano, Eric P; McGinnis, Sean P; Hochella, Michael F; Rejeski, David; Hull, Matthew S

    2015-01-01

    To document the marketing and distribution of nano-enabled products into the commercial marketplace, the Woodrow Wilson International Center for Scholars and the Project on Emerging Nanotechnologies created the Nanotechnology Consumer Products Inventory (CPI) in 2005. The objective of this present work is to redevelop the CPI by leading a research effort to increase the usefulness and reliability of this inventory. We created eight new descriptors for consumer products, including information pertaining to the nanomaterials contained in each product. The project was motivated by the recognition that a diverse group of stakeholders from academia, industry, and state/federal government had become highly dependent on the inventory as an important resource and bellweather of the pervasiveness of nanotechnology in society. We interviewed 68 nanotechnology experts to assess key information needs. Their answers guided inventory modifications by providing a clear conceptual framework best suited for user expectations. The revised inventory was released in October 2013. It currently lists 1814 consumer products from 622 companies in 32 countries. The Health and Fitness category contains the most products (762, or 42% of the total). Silver is the most frequently used nanomaterial (435 products, or 24%); however, 49% of the products (889) included in the CPI do not provide the composition of the nanomaterial used in them. About 29% of the CPI (528 products) contain nanomaterials suspended in a variety of liquid media and dermal contact is the most likely exposure scenario from their use. The majority (1288 products, or 71%) of the products do not present enough supporting information to corroborate the claim that nanomaterials are used. The modified CPI has enabled crowdsourcing capabilities, which allow users to suggest edits to any entry and permits researchers to upload new findings ranging from human and environmental exposure data to complete life cycle assessments. There

  1. Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory.

    Science.gov (United States)

    Vance, Marina E; Kuiken, Todd; Vejerano, Eric P; McGinnis, Sean P; Hochella, Michael F; Rejeski, David; Hull, Matthew S

    2015-01-01

    To document the marketing and distribution of nano-enabled products into the commercial marketplace, the Woodrow Wilson International Center for Scholars and the Project on Emerging Nanotechnologies created the Nanotechnology Consumer Products Inventory (CPI) in 2005. The objective of this present work is to redevelop the CPI by leading a research effort to increase the usefulness and reliability of this inventory. We created eight new descriptors for consumer products, including information pertaining to the nanomaterials contained in each product. The project was motivated by the recognition that a diverse group of stakeholders from academia, industry, and state/federal government had become highly dependent on the inventory as an important resource and bellweather of the pervasiveness of nanotechnology in society. We interviewed 68 nanotechnology experts to assess key information needs. Their answers guided inventory modifications by providing a clear conceptual framework best suited for user expectations. The revised inventory was released in October 2013. It currently lists 1814 consumer products from 622 companies in 32 countries. The Health and Fitness category contains the most products (762, or 42% of the total). Silver is the most frequently used nanomaterial (435 products, or 24%); however, 49% of the products (889) included in the CPI do not provide the composition of the nanomaterial used in them. About 29% of the CPI (528 products) contain nanomaterials suspended in a variety of liquid media and dermal contact is the most likely exposure scenario from their use. The majority (1288 products, or 71%) of the products do not present enough supporting information to corroborate the claim that nanomaterials are used. The modified CPI has enabled crowdsourcing capabilities, which allow users to suggest edits to any entry and permits researchers to upload new findings ranging from human and environmental exposure data to complete life cycle assessments. There

  2. Functionalized surfaces and nanostructures for nanotechnological applications

    Science.gov (United States)

    2003-01-01

    1. Introduction Despite unprecedented government funding and public interest in nanotechnology, few can accurately define the scope, range or potential applications of this technology. One of the most pressing issues facing nanoscientists and technologists today is that of communicating with the non-scientific community. As a result of decades of speculation, a number of myths have grown up around the field, making it difficult for the general public, or indeed the business and financial communities, to understand what is a fundamental shift in the way we look at our interactions with the natural world. This article attempts to address some of these misconceptions, and explain why scientists, businesses and governments are spending large amounts of time and money on nanoscale research and development. 2. What is nanotechnology? Take a random selection of scientists, engineers, investors and the general public and ask them what nanotechnology is and you will receive a range of replies as broad as nanotechnology itself. For many scientists, it is nothing startlingly new; after all we have been working at the nanoscale for decades, through electron microscopy, scanning probe microscopies or simply growing and analysing thin films. For most other groups, however, nanotechnology means something far more ambitious, miniature submarines in the bloodstream, little cogs and gears made out of atoms, space elevators made of nanotubes, and the colonization of space. It is no wonder people often muddle up nanotechnology with science fiction. 3. What is the nanoscale? Although a metre is defined by the International Standards Organization as `the length of the path travelled by light in vacuum during a time interval of 1/299 792 458 of a second' and a nanometre is by definition 10- 9 of a metre, this does not help scientists to communicate the nanoscale to non-scientists. It is in human nature to relate sizes by reference to everyday objects, and the commonest definition of

  3. Multidisciplinary Cognitive Content of Nanoscience and Nanotechnology

    CERN Document Server

    Milojević, Staša

    2012-01-01

    This article examines the cognitive evolution and disciplinary diversity of nanotechnology as expressed through the terminology used in titles of nano journal articles. The analysis is based on the NanoBank bibliographic database of 287,106 nano articles published between 1981 and 2004. We perform multifaceted analyses of title words, focusing on 100 most frequent terms. Hierarchical clustering of title terms reveals three distinct time periods of cognitive development of nano research: formative (1981-1990), early (1991-1998), and current (after 1998). Early period is characterized by the introduction of thin film deposition techniques, while the current period is characterized by the increased focus on carbon nanotube and nanoparticle research. We introduce a method to identify disciplinary components of nanotechnology. It shows that the nano research is being carried out in a number of diverse parent disciplines. Currently only 5% of articles are published in dedicated nano-only journals. We find that some...

  4. Nanotechnology for water treatment and purification

    CERN Document Server

    Apblett, Allen

    2014-01-01

    This book describes the latest progress in the application of nanotechnology for water treatment and purification. Leaders in the field present both the fundamental science and a comprehensive overview of the diverse range of tools and technologies that have been developed in this critical area. Expert chapters present the unique physicochemical and surface properties of nanoparticles and the advantages that these provide for engineering applications that ensure a supply of safe drinking water for our growing population. Application areas include generating fresh water from seawater, preventing contamination of the environment, and creating effective and efficient methods for remediation of polluted waters. The chapter authors are leading world-wide experts in the field with either academic or industrial experience, ensuring that this comprehensive volume presents the state-of-the-art in the integration of nanotechnology with water treatment and purification. Covers both wastewater and drinking water treatmen...

  5. Potential roles for diatomists in nanotechnology.

    Science.gov (United States)

    Gordon, Richard; Parkinson, John

    2005-01-01

    Diatoms produce diverse three-dimensional structures that, due to their exponential rate of growth, may be of use in the manufacture of components for nanotechnology as an alternative to present linear lithographic techniques. Vapor replacement of the silicon permits the conversion of diatom silica valves and other structures to metal/ceramics, with no loss of structure. The literature on diatom nanotechnology is reviewed, along with suggestions on how diatomists might enhance this emerging technology. There is a need for a systematics based catalog of parts (via genomics technologies), improved diatom culture techniques, better understanding of the mechanisms of diatom morphogenesis and motility, and genetic manipulation, mutagenesis, and selection, as via the chemostat-like compustat. Given the self-motility of raphid diatoms, they could form the basis for industrially useful nanobots.

  6. Nanotechnology for treating osteoporotic vertebral fractures

    Science.gov (United States)

    Gao, Chunxia; Wei, Donglei; Yang, Huilin; Chen, Tao; Yang, Lei

    2015-01-01

    Osteoporosis is a serious public health problem affecting hundreds of millions of aged people worldwide, with severe consequences including vertebral fractures that are associated with significant morbidity and mortality. To augment or treat osteoporotic vertebral fractures, a number of surgical approaches including minimally invasive vertebroplasty and kyphoplasty have been developed. However, these approaches face problems and difficulties with efficacy and long-term stability. Recent advances and progress in nanotechnology are opening up new opportunities to improve the surgical procedures for treating osteoporotic vertebral fractures. This article reviews the improvements enabled by new nanomaterials and focuses on new injectable biomaterials like bone cements and surgical instruments for treating vertebral fractures. This article also provides an introduction to osteoporotic vertebral fractures and current clinical treatments, along with the rationale and efficacy of utilizing nanomaterials to modify and improve biomaterials or instruments. In addition, perspectives on future trends with injectable bone cements and surgical instruments enhanced by nanotechnology are provided. PMID:26316746

  7. Nanotechnology: “Revolutionary Developments in Future”

    CERN Document Server

    CERN. Geneva

    2014-01-01

    Introductory notes will be made on the definition, structures, phenomena, functions, synthesis, properties, and characterization at the nanoscale. Some indications on nanoMaterials research and markets in Europe will be given. The spectrum of structural and functional/smart nanomaterials: metallic and ceramic materials, coating, composites ….will be reviewed Key challenges for nanomaterials design and engineering will be highlighted. The range of applications for nanotechnologies will be sumarized: for nano-electronics (information and communication), health care, energy and transport, nuclear and accelerator technologies, security and safety etc NanoMaterials and Technologies are key in future accelerator engineering: construction, operation and experimentation. Nanotechnology in next generation industries is a must. Nanometrology and standardisation (materials and equipment) are also an important items. Environmental and health implications of nanomaterials science and technology: Some guidance and safe...

  8. Introductory quantum mechanics for applied nanotechnology

    CERN Document Server

    Kim, Dae Mann

    2015-01-01

    This introductory textbook covers fundamental quantum mechanics from an application perspective, considering optoelectronic devices, biological sensors and molecular imagers as well as solar cells and field effect transistors. The book provides a brief review of classical and statistical mechanics and electromagnetism, and then turns to the quantum treatment of atoms, molecules, and chemical bonds. Aiming at senior undergraduate and graduate students in nanotechnology related areas like physics, materials science, and engineering, the book could be used at schools that offer interdisciplinary but focused training for future workers in the semiconductor industry and for the increasing number of related nanotechnology firms, and even practicing people could use it when they need to learn related concepts. The author is Professor Dae Mann Kim from the Korea Institute for Advanced Study who has been teaching Quantum Mechanics to engineering, material science and physics students for over 25 years in USA and Asia.

  9. Integrative filtration research and sustainable nanotechnology

    Institute of Scientific and Technical Information of China (English)

    Jing Wang; Drew Thompson; David Y.H.Pui

    2013-01-01

    With the wide applications of nanomaterials in an array of industries,more concerns are being raised about the occupational health and safety of nanoparticles in the workplace,and implications of nanotechnology on the environment and living systems.Studies on environmental,health and safety (EHS) issues of nanomaterials play a significant role in public acceptance,and eventual sustainability,of nanotechnology.We present research results on three aspects of the EHS studies:characterization and measurement of nanoparticles,nanoparticle emission and exposure at workplaces,and control and abatement of nanoparticle release using filtration technology.Measurement of nanoparticle agglomerates using a newly developed instrument,the Universal Nanoparticle Analyzer,is discussed.Nanoparticle emission and exposure measurement results for carbon nanotubes in the manufacture of nanocomposites and for silicon nanoparticles in their production at a pilot scale facility are presented.Filtration of nanoparticles and nanoparticle agglomerates are also studied.

  10. 3rd International Conference Nanotechnology and Nanomaterials

    CERN Document Server

    Yatsenko, Leonid

    2016-01-01

    This book presents some of the latest achievements in nanotechnology and nanomaterials from leading researchers in Ukraine, Europe, and beyond. It features contributions from participants in the 3rd International Science and Practice Conference Nanotechnology and Nanomaterials (NANO2015) held in Lviv, Ukraine on August 26-30, 2015. The International Conference was organized jointly by the Institute of Physics of the National Academy of Sciences of Ukraine, University of Tartu (Estonia), Ivan Franko National University of Lviv (Ukraine), University of Turin (Italy), Pierre and Marie Curie University (France), and European Profiles A.E. (Greece). Internationally recognized experts from a wide range of universities and research institutions share their knowledge and key results on topics ranging from nanooptics, nanoplasmonics, and interface studies to energy storage and biomedical applications. Presents cutting-edge advances in nanocomposites and carbon and silicon-based nanomaterials for a wide range of engine...

  11. Atherosclerosis and Nanotechnology: Diagnostic and Therapeutic Applications.

    Science.gov (United States)

    Kratz, Jeremy D; Chaddha, Ashish; Bhattacharjee, Somnath; Goonewardena, Sascha N

    2016-02-01

    Over the past several decades, tremendous advances have been made in the understanding, diagnosis, and treatment of coronary artery disease (CAD). However, with shifting demographics and evolving risk factors we now face new challenges that must be met in order to further advance are management of patients with CAD. In parallel with advances in our mechanistic appreciation of CAD and atherosclerosis, nanotechnology approaches have greatly expanded, offering the potential for significant improvements in our diagnostic and therapeutic management of CAD. To realize this potential we must go beyond to recognize new frontiers including knowledge gaps between understanding atherosclerosis to the translation of targeted molecular tools. This review highlights nanotechnology applications for imaging and therapeutic advancements in CAD. PMID:26809711

  12. The Social Relevance of Nanotechnology in Mexico

    Directory of Open Access Journals (Sweden)

    Edgar Zayago Lau

    2013-07-01

    Full Text Available The author explores the institutional and policy changes that have shaped nanotechnology development in Mexico. It illustrates how the science and technology platform has changed from a science push strategy (based on the Sabato´s Triangle to a marked driven (Triple Helix approach. Mexican public policy in NT, while not explicitly stated, is based on the Triple Helix model, and it is in this milieu that businesses, government and universities interact to transform the potential of this technology into an increase in competitiveness. However, there are important aspects that are ignored in the confluence of the socioeconomic dynamic of the country that might obscure the positive social impacts of nanotechnology.

  13. Answer Ranking with Discourse Structure Feature

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    For the complex questions of Chinese question answering system, we propose an answer extraction method with discourse structure feature combination. This method uses the relevance of questions and answers to learn to rank the answers. Firstly, the method analyses questions to generate the query string, and then submits the query string to search engines to retrieve relevant documents. Sec- ondly, the method makes retrieved documents seg- mentation and identifies the most relevant candidate answers, in addition, it uses the rhetorical relations of rhetorical structure theory to analyze the relationship to determine the inherent relationship between para- graphs or sentences and generate the answer candi- date paragraphs or sentences. Thirdly, we construct the answer ranking model,, and extract five feature groups and adopt Ranking Support Vector Machine (SVM) algorithm to train ranking model. Finally, it re-ranks the answers with the training model and fred the optimal answers. Experiments show that the proposed method combined with discourse structure features can effectively improve the answer extrac- ting accuracy and the quality of non-factoid an- swers. The Mean Reciprocal Rank (MRR) of the an- swer extraction reaches 69.53%.

  14. Answering the endocrine test questions.

    OpenAIRE

    Schmidt, C W

    1999-01-01

    Evidence suggesting that certain chemicals may bind to endogenous hormone receptors and disturb normal endocrine functioning, thereby increasing the risk of reproductive problems and cancer in humans, has led to international efforts to screen chemicals for endocrine activity and potential health effects. The U.S. Environmental Protection Agency (EPA) has recommended that some 87,000 commercial chemicals for which there currently are inadequate toxicity data be evaluated. In December 1998, th...

  15. Nanotechnology Research: Applications in Nutritional Sciences12

    OpenAIRE

    Srinivas, Pothur R.; Philbert, Martin; Vu, Tania Q.; Huang, Qingrong; Kokini, Josef L.; Saos, Etta; Chen, Hongda; Peterson, Charles M.; Friedl, Karl E.; McDade-Ngutter, Crystal; Hubbard, Van; Starke-Reed, Pamela; Miller, Nancy; Betz, Joseph M.; Dwyer, Johanna

    2010-01-01

    The tantalizing potential of nanotechnology is to fabricate and combine nanoscale approaches and building blocks to make useful tools and, ultimately, interventions for medical science, including nutritional science, at the scale of ∼1–100 nm. In the past few years, tools and techniques that facilitate studies and interventions in the nanoscale range have become widely available and have drawn widespread attention. Recently, investigators in the food and nutrition sciences have been applying ...

  16. Targeting of antileishmanial drugs produced by nanotechnologies

    OpenAIRE

    Pujals Naranjo, Georgina

    2007-01-01

    The aim of this work is to develop an effective new MGA delivery system by means of nanotechnology for the treatment of leishmaniosis which could be administered by parenteral or oral route in a future. Moreover, for ensuring the effectiveness of the formulations developed, their in vitro activities will be assessed against L. infantum. The intention is to prepare a target drug delivery system by means of different technological strategies like micro-nanoparticles by spray drying. These formu...

  17. Agricultural Nanotechnologies: what are the current possibilities?

    OpenAIRE

    PARISI CLAUDIA; VIGANI MAURO; Rodriguez Cerezo, Emilio

    2014-01-01

    Innovation is at the centre of the EU's growth strategy for the coming decade (EU2020). New technologies and their adoption by EU farmers are essential in maintaining European agriculture competitive in a global world. Nanotechnology represents an innovative technology in many areas of applications and is showing a great potential in the agricultural sector, in particular for the development of more precise and effective methods for disease diagnosis and treatment in crop plants. The Insti...

  18. Knowledge transfer activities of scientists in nanotechnology

    OpenAIRE

    Zalewska-Kurek, Kasia; Egedova, Klaudia; Geurts, Peter A.Th.M.; Roosendaal, Hans E.

    2016-01-01

    In this paper, we present a theory of strategic positioning that explains scientists’ strategic behavior in knowledge transfer from university to industry. The theory is based on the drivers strategic interdependence and organizational autonomy and entails three modes of behavior of scientists: mode1, mode2, and mode3 (the research entrepreneur). The results of an empirical study conducted at a research institute for nanotechnology show that, to increase the likelihood of scientists engaging ...

  19. Multidisciplinary Cognitive Content of Nanoscience and Nanotechnology

    OpenAIRE

    Milojević, Staša

    2012-01-01

    This article examines the cognitive evolution and disciplinary diversity of nanotechnology as expressed through the terminology used in titles of nano journal articles. The analysis is based on the NanoBank bibliographic database of 287,106 nano articles published between 1981 and 2004. We perform multifaceted analyses of title words, focusing on 100 most frequent terms. Hierarchical clustering of title terms reveals three distinct time periods of cognitive development of nano research: forma...

  20. Nanotechnology in dentistry: Present and future

    OpenAIRE

    Bhardwaj, Archana; Bhardwaj, Abhishek; Misuriya, Abhinav; Maroli, Sohani; Manjula, S.; Singh, Arvind Kumar

    2014-01-01

    Nanotechnology is the manipulation of matter on the molecular and atomic levels. It has the potential to bring enormous changes into the fields of medicine and dentistry. A day may soon come when nanodentistry will succeed in maintaining near-perfect oral health through the aid of nanorobotics, nanomaterials and biotechnology. However, as with all developments, it may also pose a risk for misuse. Time, economical and technical resources, and human needs will determine the direction this revol...

  1. The changing face of dentistry: nanotechnology

    OpenAIRE

    Kanaparthy R; Kanaparthy A

    2011-01-01

    Rosaiah Kanaparthy1, Aruna Kanaparthy2 1Department of Periodontics, 2Conservative Dentistry, Peoples Dental Academy, Bhopal, Madhya Pradesh, India Abstract: The human body comprises molecules; hence, the availability of molecular nanotechnology will permit dramatic progress to address medical problems and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine could develop devices that are able to work inside the human body in order to identify...

  2. Innovations in nanotechnology for water treatment

    OpenAIRE

    Gehrke I; Geiser A.; Somborn-Schulz A

    2015-01-01

    Ilka Gehrke, Andreas Geiser, Annette Somborn-SchulzFraunhofer Institute for Environmental, Safety and Energy Technology UMSICHT, Oberhausen, GermanyAbstract: Important challenges in the global water situation, mainly resulting from worldwide population growth and climate change, require novel innovative water technologies in order to ensure a supply of drinking water and reduce global water pollution. Against this background, the adaptation of highly advanced nanotechnology to traditional pro...

  3. Antimicrobial applications of nanotechnology: methods and literature

    OpenAIRE

    Seil JT; Webster TJ

    2012-01-01

    Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, School of Engineering, Brown University, Providence, RI, USAAbstract: The need for novel antibiotics comes from the relatively high incidence of bacterial infection and the growing resistance of bacteria to conventional antibiotics. Consequently, new methods for reducing bacteria activity (and associated infections) are badly needed. Nanotechnology, the use of materials with dimensions on the atomic or molecular scale, has b...

  4. Nanotechnology, bionanotechnology and microbial cell factories

    OpenAIRE

    Villaverde Antonio

    2010-01-01

    Abstract Nanotechnology is increasingly using both materials and nano-objects synthesized by living beings, most of them produced by microbial cells. Emerging technologies and highly integrative approaches (such as 'omics and systems biology), that have been largely proven successful for the production of proteins and secondary metabolites are now expected to become fully adapted for the improved biological production of nanostructured materials with tailored properties. The so far underestim...

  5. New technical solutions in nanotechnology. Part 1

    OpenAIRE

    IVANOV Leonid Alexeevich; MUMINOVA Svetlana Rashidovna

    2016-01-01

    The new technical solutions including inventions in the area of nanotechnology and nanomaterials are efficiently applied in communal and housing services as well as in construction and other joint fields. The invention «The method to purify surface and underground water from titanium and compounds of it by means of carbon nanotubes and ultrasound (RU 2575029)» refers to absorptive treatment of surface and underground waters with rich content of titanium and its compounds and can be used to ob...

  6. Articulation: how societal goals matter in nanotechnology

    OpenAIRE

    Bos, C.

    2016-01-01

    Science policies try to steer scientists to conduct societally relevant research. This societal relevance is often expressed in large societal goals, such as addressing sustainability or helping with the problems that an ageing society might bring. Emerging technologies, like nanotechnology, are often surrounded by large expectation on how they might contribute to societal progress. It is however unclear how such broad and unarticulated ambitions relate to the actual development of new techno...

  7. New technical solutions in nanotechnology. Part 2

    OpenAIRE

    IVANOV Leonid Alexeevich; MUMINOVA Svetlana Rashidovna

    2016-01-01

    The new technical solutions including inventions in the area of nanotechnology and nanomaterials are efficiently applied in communal and housing services as well as in construction and other joint fields. The invention «The diagnostics method for defects on the metal surfaces (RU 2581441)» refers to the methods used to detect defects and cracks on the surface of metal equipment and pipe lines. The suspension of metal nanoparticles is consistently applied on the surface of controlled object fo...

  8. The Social Relevance of Nanotechnology in Mexico

    OpenAIRE

    Edgar Zayago Lau

    2013-01-01

    The author explores the institutional and policy changes that have shaped nanotechnology development in Mexico. It illustrates how the science and technology platform has changed from a science push strategy (based on the Sabato´s Triangle) to a marked driven (Triple Helix) approach. Mexican public policy in NT, while not explicitly stated, is based on the Triple Helix model, and it is in this milieu that businesses, government and universities interact to transform the potential of this tech...

  9. A review of water treatment membrane nanotechnologies

    KAUST Repository

    Pendergast, MaryTheresa M.

    2011-01-01

    Nanotechnology is being used to enhance conventional ceramic and polymeric water treatment membrane materials through various avenues. Among the numerous concepts proposed, the most promising to date include zeolitic and catalytic nanoparticle coated ceramic membranes, hybrid inorganic-organic nanocomposite membranes, and bio-inspired membranes such as hybrid protein-polymer biomimetic membranes, aligned nanotube membranes, and isoporous block copolymer membranes. A semi-quantitative ranking system was proposed considering projected performance enhancement (over state-of-the-art analogs) and state of commercial readiness. Performance enhancement was based on water permeability, solute selectivity, and operational robustness, while commercial readiness was based on known or anticipated material costs, scalability (for large scale water treatment applications), and compatibility with existing manufacturing infrastructure. Overall, bio-inspired membranes are farthest from commercial reality, but offer the most promise for performance enhancements; however, nanocomposite membranes offering significant performance enhancements are already commercially available. Zeolitic and catalytic membranes appear reasonably far from commercial reality and offer small to moderate performance enhancements. The ranking of each membrane nanotechnology is discussed along with the key commercialization hurdles for each membrane nanotechnology. © 2011 The Royal Society of Chemistry.

  10. Nanotechnological Strategies for Biofabrication of Human Organs

    Directory of Open Access Journals (Sweden)

    Rodrigo A. Rezende

    2012-01-01

    Full Text Available Nanotechnology is a rapidly emerging technology dealing with so-called nanomaterials which at least in one dimension have size smaller than 100 nm. One of the most potentially promising applications of nanotechnology is in the area of tissue engineering, including biofabrication of 3D human tissues and organs. This paper focused on demonstrating how nanomaterials with nanolevel size can contribute to development of 3D human tissues and organs which have macrolevel organization. Specific nanomaterials such as nanofibers and nanoparticles are discussed in the context of their application for biofabricating 3D human tissues and organs. Several examples of novel tissue and organ biofabrication technologies based on using novel nanomaterials are presented and their recent limitations are analyzed. A robotic device for fabrication of compliant composite electrospun vascular graft is described. The concept of self-assembling magnetic tissue spheroids as an intermediate structure between nano- and macrolevel organization and building blocks for biofabrication of complex 3D human tissues and organs is introduced. The design of in vivo robotic bioprinter based on this concept and magnetic levitation of tissue spheroids labeled with magnetic nanoparticles is presented. The challenges and future prospects of applying nanomaterials and nanotechnological strategies in organ biofabrication are outlined.

  11. Empowering citizens in international governance of nanotechnologies

    Energy Technology Data Exchange (ETDEWEB)

    Malsch, Ineke, E-mail: malschtechnovaluation@xs4all.nl, E-mail: postbus@malsch.demon.nl [Malsch TechnoValuation (Netherlands); Subramanian, Vrishali; Semenzin, Elena; Hristozov, Danail; Marcomini, Antonio [Ca’Foscari University of Venice, Department of Environmental Sciences, Informatics and Statistics (Italy); Mullins, Martin; Hester, Karena; McAlea, Eamonn; Murphy, Finbarr [University of Limerick, Department of Accounting and Finance, Kemmy Business School (Ireland); Tofail, Syed A. M. [University of Limerick, Department of Physics and Energy, and Materials and Surface Sciences Institute (MSSI) (Ireland)

    2015-05-15

    The international dialogue on responsible governance of nanotechnologies engages a wide range of actors with conflicting as well as common interests. It is also characterised by a lack of evidence-based data on uncertain risks of in particular engineered nanomaterials. The present paper aims at deepening understanding of the collective decision making context at international level using the grounded theory approach as proposed by Glaser and Strauss in “The Discovery of Grounded Theory” (1967). This starts by discussing relevant concepts from different fields including sociological and political studies of international relations as well as political philosophy and ethics. This analysis of current trends in international law making is taken as starting point for exploring the role that a software decision support tool could play in multi-stakeholder global governance of nanotechnologies. These theoretical ideas are then compared with the current design of the SUN Decision Support System (SUNDS) under development in the European project on Sustainable Nanotechnologies (SUN, www.sun-fp7.eu http://www.sun-fp7.eu ). Through constant comparison, the ideas are also compared with requirements of different stakeholders as expressed during a user workshop. This allows for highlighting discussion points for further consideration.

  12. Empowering citizens in international governance of nanotechnologies

    International Nuclear Information System (INIS)

    The international dialogue on responsible governance of nanotechnologies engages a wide range of actors with conflicting as well as common interests. It is also characterised by a lack of evidence-based data on uncertain risks of in particular engineered nanomaterials. The present paper aims at deepening understanding of the collective decision making context at international level using the grounded theory approach as proposed by Glaser and Strauss in “The Discovery of Grounded Theory” (1967). This starts by discussing relevant concepts from different fields including sociological and political studies of international relations as well as political philosophy and ethics. This analysis of current trends in international law making is taken as starting point for exploring the role that a software decision support tool could play in multi-stakeholder global governance of nanotechnologies. These theoretical ideas are then compared with the current design of the SUN Decision Support System (SUNDS) under development in the European project on Sustainable Nanotechnologies (SUN, www.sun-fp7.eu http://www.sun-fp7.eu ). Through constant comparison, the ideas are also compared with requirements of different stakeholders as expressed during a user workshop. This allows for highlighting discussion points for further consideration

  13. How helpful is nanotechnology in agriculture?

    International Nuclear Information System (INIS)

    Nanotechnology has great potential, as it can enhance the quality of life through its applications in various fields like agriculture and the food system. Around the world it has become the future of any nation. But we must be very careful with any new technology to be introduced regarding its possible unforeseen related risks that may come through its positive potential. However, it is also critical for the future of a nation to produce a trained future workforce in nanotechnology. In this process, to inform the public at large about its advantages is the first step; it will result in a tremendous increase in interest and new applications in all the domains will be discovered. With this idea, the present review has been written. There is great potential in nanoscience and technology in the provision of state-of-the-art solutions for various challenges faced by agriculture and society today and in the future. Climate change, urbanization, sustainable use of natural resources and environmental issues like runoff and accumulation of pesticides and fertilizers are the hot issues for today's agriculture. This paper reviews some of the potential applications of nanotechnology in the field of agriculture and recommends many strategies for the advancement of scientific and technological knowledge currently being examined. (review)

  14. Bioethical Issues of Nanotechnology at a Glance

    Directory of Open Access Journals (Sweden)

    M Aala

    2008-06-01

    Full Text Available Nanotechnology is considered as an industrial revolution of the third millennium. Advances have a remarkable impact on differ¬ent fields such as medicine, engineering, economy and even politics. However, a wide range of ethical issues has been raised by this innovative science. Many authorities believe that these advancements could lead to irreversible dis¬asters if not lim¬ited by ethical guidelines. Involvement of developing countries in new fields of science could be as¬sociated with substan¬tial advantages. In this paper, we intend to review main ethical issues of nanotechnology, taking into account the surge of interests in this field and the ever-increasing advances of nanotechnology in Iran. The issue of safety, considering envi¬ronmental and ecological impacts of nanoparticles (smart dust, and standards of customer aware¬ness are important de¬bates. The ‘Grey-goo' scenario and the concerns about ‘post-humanism' are also discussed by bioethicists. There are further con¬cerns about justice, intellectual property rights, accountability, and the probability of military and security misuse.

  15. Nanotechnology R and D Policy of Japan and Nanotechnology Support Project

    International Nuclear Information System (INIS)

    In the 2nd Science and Technology Basic Plan (2001-2005), the area of nanotechnology and materials is designated one of the four prioritized areas in funding. Following this plan, Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Ministry of Economy, Trade and Industries (METI), the main funding ministries, and their organizations, Japan Society for the Promotion of Science (JSPS), Japan Science and Technology Agency (JST), National Institute for Materials Science (NIMS), RIKEN, New Energy and Industrial Technology Organization (NEDO), and National Institute of Advanced Industrial Science and Technology (AIST) promotes their research programs. Besides, in order to promote interdisciplinary, interorganizational, and international collaboration of researchers, Nanotechnology Support Project (NSP) was started by MEXT in 2002. The project has two missions: informational support and common use facility support. Nanotechnology Researchers Network Center of Japan is responsible for informational support, and 14 universities and national research institutes are responsible for common use facility support

  16. FVQA: Fact-based Visual Question Answering

    OpenAIRE

    Wang, Peng; Wu, Qi; Shen, Chunhua; Hengel, Anton van den; Dick, Anthony

    2016-01-01

    Visual Question Answering (VQA) has attracted a lot of attention in both Computer Vision and Natural Language Processing communities, not least because it off?ers insight into the relationships between two important sources of information. Current datasets, and the models built upon them, have focused on questions which are answerable by direct analysis of the question and image alone. The set of such questions that require no external information to answer is interesting, but very limited. I...

  17. Nanotechnology in agriculture: prospects and constraints

    Directory of Open Access Journals (Sweden)

    Mukhopadhyay SS

    2014-08-01

    Full Text Available Siddhartha S Mukhopadhyay Electron Microscopy and Nanoscience Laboratory, Punjab Agricultural University, Ludhiana, India Abstract: Attempts to apply nanotechnology in agriculture began with the growing realization that conventional farming technologies would neither be able to increase productivity any further nor restore ecosystems damaged by existing technologies back to their pristine state; in particular because the long-term effects of farming with “miracle seeds”, in conjunction with irrigation, fertilizers, and pesticides, have been questioned both at the scientific and policy levels, and must be gradually phased out. Nanotechnology in agriculture has gained momentum in the last decade with an abundance of public funding, but the pace of development is modest, even though many disciplines come under the umbrella of agriculture. This could be attributed to: a unique nature of farm production, which functions as an open system whereby energy and matter are exchanged freely; the scale of demand of input materials always being gigantic in contrast with industrial nanoproducts; an absence of control over the input nanomaterials in contrast with industrial nanoproducts (eg, the cell phone and because their fate has to be conceived on the geosphere (pedosphere-biosphere-hydrosphere-atmosphere continuum; the time lag of emerging technologies reaching the farmers' field, especially given that many emerging economies are unwilling to spend on innovation; and the lack of foresight resulting from agricultural education not having attracted a sufficient number of brilliant minds the world over, while personnel from kindred disciplines might lack an understanding of agricultural production systems. If these issues are taken care of, nanotechnologic intervention in farming has bright prospects for improving the efficiency of nutrient use through nanoformulations of fertilizers, breaking yield barriers through bionanotechnology, surveillance and

  18. From Question Answering to Visual Exploration

    Energy Technology Data Exchange (ETDEWEB)

    McColgin, Dave W.; Gregory, Michelle L.; Hetzler, Elizabeth G.; Turner, Alan E.

    2006-08-11

    Research in Question Answering has focused on the quality of information retrieval or extraction using the metrics of precision and recall to judge success; these metrics drive toward finding the specific best answer(s) and are best supportive of a lookup type of search. These do not address the opportunity that users? natural language questions present for exploratory interactions. In this paper, we present an integrated Question Answering environment that combines a visual analytics tool for unstructured text and a state-of-the-art query expansion tool designed to compliment the cognitive processes associated with an information analysts work flow. Analysts are seldom looking for factoid answers to simple questions; their information needs are much more complex in that they may be interested in patterns of answers over time, conflicting information, and even related non-answer data may be critical to learning about a problem or reaching prudent conclusions. In our visual analytics tool, questions result in a comprehensive answer space that allows users to explore the variety within the answers and spot related information in the rest of the data. The exploratory nature of the dialog between the user and this system requires tailored evaluation methods that better address the evolving user goals and counter cognitive biases inherent to exploratory search tasks.

  19. Editorial: Trends in Nanotechnology (TNT2005)

    Science.gov (United States)

    Correia, Antonio; Serena, Pedro A.; José Saenz, Juan; Reifenberger, Ron; Ordejón, Pablo

    2006-05-01

    This special issue of physica status solidi (a) presents representative contributions describing the main topics covered at the sixth Trends in Nanotechnology (TNT2005) International Conference, held in Oviedo (Spain), 29 August-2 September 2005.During the last years many international or national conferences have emerged in response to the growing awareness of the importance of nanotechnology as key issue for the future scientific and technological development. Among these, the conference series Trends in Nanotechnology has become one of the most important meeting points in the nanotechnology field: it provides fresh organisation ideas, brings together well known speakers, and promotes a suitable environment for discussions, exchanging ideas, enhancing scientific and personal relations among participants. TNT2005 was organised in a similar way to the five prior TNT conferences, with an impressive scientific programme including 40 Keynote lectures and two Nobel prizes, without parallel sessions, covering a wide spectrum of Nanotechnology research. In 2005, more than 360 scientists worldwide attended this event and contributed with more than 60 oral contributions and 250 posters, stimulating discussions about their most recent research.The aim of the conference was to focus on the applications of Nanotechnology and to bring together, in a scientific forum, various worldwide groups belonging to industry, universities and government institutions. TNT2005 was particularly effective at transmitting information and establishing contacts among workers in this field. Graduate students attending such conferences have understood the importance of interdisciplinary skills to afford their future research lines. 76 graduate students received a grant allowing them to present their work. 28 prizes to the best posters were awarded during this event. We would like to thank all the participants for their assistance, as well as the authors for their written contributions.TNT2005 is

  20. Does anyone know the answer to that question? Individual differences in judging answerability

    Directory of Open Access Journals (Sweden)

    Bodil S. A. Karlsson

    2016-01-01

    Full Text Available Occasionally people may attempt to judge whether a question can be answered today, or if not, if it can be answered in the future. For example, a person may consider whether enough is known about the dangers of living close to a nuclear plant, or to a major electricity cable, for them to be willing to do so, and state-authorities may consider whether questions about the dangers of new technologies have been answered, or in a reasonable future can be, for them to be willing to invest money in research aiming develop such technologies. A total of 476 participants, for each of 22 knowledge questions, either judged whether it was answerable today (current answerability, or judged when it could be answered (future answerability. The knowledge questions varied with respect to the expected consensus concerning their answerability: consensus questions (high expected consensus, non-consensus questions (lower expected consensus and illusion questions (formulated to appear answerable, but with crucial information absent. The questions’ judged answerability level on the two scales was highly correlated. For both scales, consensus questions were rated more answerable than the non-consensus questions, with illusion questions falling in-between. The result for the illusion questions indicates that a feeling of answerability can be created even when it is unlikely that somebody can come up with an answer. The results also showed that individual difference variables influenced the answerability judgments. Higher levels of belief in certainty of knowledge, mankind’s knowledge, and mankind’s efficacy were related to judging the non-consensus questions as more answerable. Participants rating the illusion questions as answerable rated the other answerability questions as more, or equally, answerable compared to the other participants and showed tendencies to prefer a combination of more epistemic default processing and less intellectual processing.

  1. Nanotechnology-based strategies for the detection and quantification of microRNA.

    Science.gov (United States)

    Degliangeli, Federica; Pompa, Pier Paolo; Fiammengo, Roberto

    2014-07-28

    MicroRNAs (miRNAs) are important regulators of gene expression, and many pathological conditions, including cancer, are characterized by altered miRNA expression levels. Therefore, accurate and sensitive quantification of miRNAs may result in correct disease diagnosis establishing these small noncoding RNA transcripts as valuable biomarkers. Aiming at overcoming some limitations of conventional quantification strategies, nanotechnology is currently providing numerous significant alternatives to miRNA sensing. In this review an up-to-date account of nanotechnology-based strategies for miRNA detection and quantification is given. The topics covered are: nanoparticle-based approaches in solution, sensing based on nanostructured surfaces, combined nanoparticle/surface sensing approaches, and single-molecule approaches.

  2. Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy.

    Science.gov (United States)

    Brys, Adam K; Gowda, Raghavendra; Loriaux, Daniel B; Robertson, Gavin P; Mosca, Paul J

    2016-01-01

    Drug toxicity and resistance remain formidable challenges in cancer treatment and represent an area of increasing attention in the case of melanoma. Nanotechnology represents a paradigm-shifting field with the potential to mitigate drug resistance while improving drug delivery and minimizing toxicity. Recent clinical and pre-clinical studies have demonstrated how a diverse array of nanoparticles may be harnessed to circumvent known mechanisms of drug resistance in melanoma to improve therapeutic efficacy. In this review, we discuss known mechanisms of resistance to various melanoma therapies and possible nanotechnology-based strategies that could be used to overcome these barriers and improve the pharmacologic arsenal available to combat advanced stage melanoma. PMID:26826558

  3. Recent advances in nanotechnology-based detection and separation of circulating tumor cells.

    Science.gov (United States)

    Myung, Ja Hye; Tam, Kevin A; Park, Sin-jung; Cha, Ashley; Hong, Seungpyo

    2016-01-01

    Although circulating tumor cells (CTCs) in blood have been widely investigated as a potential biomarker for diagnosis and prognosis of metastatic cancer, their inherent rarity and heterogeneity bring tremendous challenges to develop a CTC detection method with clinically significant specificity and sensitivity. With advances in nanotechnology, a series of new methods that are highly promising have emerged to enable or enhance detection and separation of CTCs from blood. In this review, we systematically categorize nanomaterials, such as gold nanoparticles, magnetic nanoparticles, quantum dots, graphenes/graphene oxides, and dendrimers and stimuli-responsive polymers, used in the newly developed CTC detection methods. This will provide a comprehensive overview of recent advances in the CTC detection achieved through application of nanotechnology as well as the challenges that these existing technologies must overcome to be directly impactful on human health. PMID:26296639

  4. Nanotechnology Innovations and Commercialization – Opportunities, Challenges & Reasons for Delay

    OpenAIRE

    Aithal, Sreeramana; Aithal, Shubhrajyotsna

    2016-01-01

    Innovations in nanotechnology are making a revolution in manufacturing and production, creating new materials and products through novel processes for commercial applications. New products based on nanotechnology with novel characteristics are continued to grow and benefit the society. Being general purpose technology, nanotechnology is expected to support all fields of the society, but some fields like medicine, energy, environmental remediation, robotics, manufacturing, commerce, and space...

  5. A Study of VLSI Technology, Wafers and Impact on Nanotechnology

    OpenAIRE

    Gupta, Kiran; Nair, T. R. Gopalakrishnan

    2010-01-01

    This paper presents a detailed study of the present VLSI technological aspects, importance and their replacement or combination with the Nanotechnology in the VLSI world of silicon semiconductors. Here authors bring out the nanotechnology in Silicon world which invariably means shrinking geometry of CMOS devices to nano scale. This also refers to a new world of nanotechnology where chemists are working in manufacturing of carbon nanotubes , nano devices of varius materials of nano dimensions ...

  6. Nanotechnology applications in foods-packagings and importance for seafoods

    OpenAIRE

    Göknur Sürengil; Berna Kılınç

    2011-01-01

    Nanotechnology 100 nanometer scale in a small and rapidly developing science and technology field. Each area of nanotechnology to create advanced products with new techniques, medicine, health, food, packaging materials and systems, pharmaceutical, electronic industries, such as benefits. Utilization of nanotechnology in the food sector to a limited extent useful and impor¬tant, although still used. In recent years, studies worldwide food industry is seeking ways to exploit this technology th...

  7. Consumer perceptions of nanotechnology applications in Italian wine

    OpenAIRE

    E. Chiodo; N. Casolani; G.M. Greehy; Fantini, A.; M.B. McCarthy

    2015-01-01

    This paper examines Italian consumer acceptance of nanotechnology applications in wine production, surveying wine consumers from the Abruzzo Region. Conjoint and post-hoc segmentation analysis establishes how consumers value different wine product attributes and place them within the context of applications of nanotechnology. Consumers appear relatively unfamiliar with nanotechnology applications, both generally and specifically to food. Although, an overall rejection of the concept of “nano ...

  8. Not another GMO: explaining Europe's approach to nanotechnologies

    OpenAIRE

    Jaspers, Nico

    2012-01-01

    Despite early warnings about “knowledge-enabled mass destruction” and the ongoing battle over agricultural biotechnology, the development of nanotechnology in Europe has been remarkably quiet over the past decade: non-governmental organization (NGO) campaigns against “nano” were all but inexistent and the wider public appears largely uninterested in nanotechnology. Why has Europe’s experience with nanotechnologies been so fundamentally different from that with genetically modified organisms (...

  9. Nanotechnology in agri-food production: an overview

    OpenAIRE

    Sekhon BS

    2014-01-01

    Bhupinder Singh SekhonInstitute of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, IndiaAbstract: Nanotechnology is one of the most important tools in modern agriculture, and agri-food nanotechnology is anticipated to become a driving economic force in the near future. Agri-food themes focus on sustainability and protection of agriculturally produced foods, including crops for human consumption and animal feeding. Nanotechnology provides new agrochemical agents and new delivery m...

  10. A Boost for the Emerging Field of RNA Nanotechnology

    OpenAIRE

    Shukla, Girish C.; Haque, Farzin; Tor, Yitzhak; Wilhelmsson, L. Marcus; Toulmé, Jean-Jacques; Isambert, Hervé; Guo, Peixuan; John J. Rossi; Tenenbaum, Scott A.; Shapiro, Bruce A.

    2011-01-01

    This Nano Focus article highlights recent advances in RNA nanotechnology as presented at the First International Conference of RNA Nanotechnology and Therapeutics, which took place in Cleveland, OH, USA (October 23–25, 2010) (http://www.eng.uc.edu/nanomedicine/RNA2010/), chaired by Peixuan Guo and co-chaired by David Rueda and Scott Tenenbaum. The conference was the first of its kind to bring together more than 30 invited speakers in the frontier of RNA nanotechnology from France, Sweden, Sou...

  11. Research trends in nanotechnology studies across geo-economic areas

    OpenAIRE

    Mario Coccia; Ugo Finardi; Diego Margon

    2010-01-01

    The purpose of this paper is to analyze the current temporal and spatial research trajectories in nanoscience and nanotechnology studies in order to display the worldwide patterns of research fields across main economic players. The results show the leadership of Europe and North America in nanotechnology research, although the role of China has been growing over time. Current nanotechnology studies have been growing in chemistry and medicine because of applications of nanomaterials mainly in...

  12. NANOTECHNOLOGY: A PROMISING CARRIER FOR INTRACELLULAR DRUG DELIVERY SYSTEM

    OpenAIRE

    Malakar Jadupati; Ghosh Amitava; Basu Aalok; Nayak Amit Kumar

    2012-01-01

    Nanotechnology is on its way to make a big impact in Biotech, Pharmaceutical and Medical diagnostics sciences. Nanotechnology holds a tremendous potential when it applied in the fields of drug delivery. In this review it has been discussed how nanotechnology can implemented to design formulations which can effectively carry drug molecule to the targeted cell organelles. Introduction of certain functional groups or addition of surface active agents may alter the characteristics of the carrier ...

  13. Advances in Nanotechnology for the Management of Coronary Artery Disease

    OpenAIRE

    Rhee, June-Wha; Wu, Joseph C.

    2012-01-01

    Nanotechnology holds tremendous potential to advance the current treatment of coronary artery disease. Nanotechnology may assist medical therapies by providing a safe and efficacious delivery platform for a variety of drugs aimed at modulating lipid disorders, decreasing inflammation and angiogenesis within atherosclerotic plaques, and preventing plaque thrombosis. Nanotechnology may improve coronary stent applications by promoting endothelial recovery on a stent surface utilizing bio-mimetic...

  14. Nanotechnology and the Emergence of a General Purpose Technology

    OpenAIRE

    Stuart GRAHAM; Iacopetta, Maurizio

    2014-01-01

    This article examines how closely nanotechnology resembles a general purpose technology (GPT). Using patented nanotechnology inventions during 1975-2006, we test for characteristics of GPTs identified in the prior literature, and find evidence that nanotechnology shows both "pervasive" adoption and "spawning" of follow-on innovation. Offering a methodological contribution, we employ concentration indexes such as the Gini index and Lorenz curve to construct "knowledge dissemination curves" for...

  15. Micro and nanotechnology commercialization: balance between exploration and exploitation

    OpenAIRE

    WHC Knol

    2005-01-01

    Innovative materials, components, and systems based on micro and nanotechnologies are recognized as promising growth innovators. The coming years the commercialization of micro and nanotechnology will be extended, but in order to commercialize micro and nanotechnology successfully, besides exploration a parallel focus should be aimed at exploitation. This paper presents in a brief and non-exhaustive manor a theoretical introduction and two company introductions related to exploitation and exp...

  16. Applications of electrochemistry and nanotechnology in biology and medicine II

    CERN Document Server

    Eliaz, Noam

    2011-01-01

    The study of electrochemical nanotechnology has emerged as researchers apply electrochemistry to nanoscience and nanotechnology. These two related volumes in the Modern Aspects of Electrochemistry Series review recent developments and breakthroughs in the specific application of electrochemistry and nanotechnology to biology and medicine. Internationally renowned experts contribute chapters that address both fundamental and practical aspects of several key emerging technologies in biomedicine, such as the processing of new biomaterials, biofunctionalization of surfaces, characterization of bio

  17. Inequality gaps in nanotechnology development in Latin America

    Directory of Open Access Journals (Sweden)

    Guillermo Foladori

    2013-06-01

    Full Text Available Nanotechnology has been spurred by science, technology and innovation policies in most Latin American countries since the last decade. Public policies and funding have been accompanied by a common rhetoric, highlighting the potential of nanotechnology for increasing competitiveness and growth and providing the region with more efficient and innovative products. Based on an assessment of nanotechnology policies and capabilities in nine countries this article highlights three characteristics of nanotechnology in Latin America that might hinder its contribution to an equitable development within the region. The first characteristic is the conspicuous trend towards an intra-regional gap in capacity building as a result of the unequal historical development of science and technology among these countries and the large differences in equipment and financial resources devoted to nanotechnology.  The second characteristic is the strength of “international signals” vis-à-vis the national needs in the orientation of nanotechnology. On the one hand, nanotechnology is main and foremost oriented to achieve international competitiveness, which may lead its development to international market demands. On the other hand, nanotechnology research in Latin American countries has been configured within internationalized academic networks, which may influence local research agendas towards foreign research priorities. The third characteristic is the absence of research on potential impacts of nanotechnology on human health and the environment, as well as other societal implications, which may generate new forms of unequal distribution of benefits and risks.

  18. Advances in nanotechnology for the management of coronary artery disease.

    Science.gov (United States)

    Rhee, June-Wha; Wu, Joseph C

    2013-02-01

    Nanotechnology holds tremendous potential to advance the current treatment of coronary artery disease. Nanotechnology may assist medical therapies by providing a safe and efficacious delivery platform for a variety of drugs aimed at modulating lipid disorders, decreasing inflammation and angiogenesis within atherosclerotic plaques, and preventing plaque thrombosis. Nanotechnology may improve coronary stent applications by promoting endothelial recovery on a stent surface utilizing bio-mimetic nanofibrous scaffolds, and also by preventing in-stent restenosis using nanoparticle-based delivery of drugs that are decoupled from stents. Additionally, nanotechnology may enhance tissue-engineered graft materials for application in coronary artery bypass grafting by facilitating cellular infiltration and remodeling of a graft matrix.

  19. The Implementation of Innovation and Resource Allocation with Nanotechnology

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    All natural and living systems are governed by atomic and molecular behavior at the nanoscale. Research is now seeking systematic approaches to create revolutionary new products and technologies by control of matter at the same scale.Nanotechnology is expected to have a profound impact on our society.The vision,research and development strategy,and timeline of the nanotechnology initiative are presented by using several recent scientific discoveries, innovations and results from industry. This article demonstrates the implications of innovation for nanotechnology development. To deal with the innovation, a theory of nanotechnology development must come to terms with the developmental, organisational, and strategic dimensions of innovative resource allocation.

  20. EDITORIAL: Ensuring sustainability with green nanotechnology Ensuring sustainability with green nanotechnology

    Science.gov (United States)

    Wong, Stanislaus; Karn, Barbara

    2012-07-01

    Nanotechnology offers immense promise for developing new technologies that are more sustainable than current technologies. All major industrial sectors have felt nanotechnology's impact, mainly from the incorporation of nanomaterials into their products. For example, nanotechnology has improved the design and performance of products in areas as diverse as electronics, medicine and medical devices, food and agriculture, cosmetics, chemicals, materials, coatings, energy, as well as many others. Moreover, the revenues from nanotechnology-enabled products are not trivial. For instance, Lux Research maintains that commercial sales in both Europe and the USA will attain revenues of over 1 trillion from nano-enabled products by 2015. The manufacturing of the nanomaterials for these products uses many processes equivalent to chemical manufacturing processes. As a result, manufacturing nanomaterials can produce either harmful pollutants or adverse environmental impacts similar to those from chemical manufacturing. Unlike the chemical industry, however, those same processes are not ingrained in the manufacturing of nanomaterials, and the opportunity exists at the initial design stage to purposely account for and mitigate out potentially harmful environmental impacts. While prevention has not been a priority in current industries, it can become a main concern for the new and future industries that manufacture nanomaterials on a bulk commercial scale. This is where green nanotechnology comes in. Green nanotechnology involves deliberate efforts aimed at developing meaningful and reasonable protocols for generating products and their associated production processes in a benign fashion. The goal is a conscious minimization of risks associated with the products of nanoscience. The green products of nanotechnology are those that are used in either direct or indirect environmental applications. Direct environmental applications provide benefits such as monitoring using nano

  1. Questions and Answers About Nuclear Power Plants.

    Science.gov (United States)

    Environmental Protection Agency, Washington, DC.

    This pamphlet is designed to answer many of the questions that have arisen about nuclear power plants and the environment. It is organized into a question and answer format, with the questions taken from those most often asked by the public. Topics include regulation of nuclear power sources, potential dangers to people's health, whether nuclear…

  2. 7 CFR 1.164 - Answer.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Answer. 1.164 Section 1.164 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Rules of Practice Governing Cease and Desist Proceedings Under Section 2 of the Capper-Volstead Act § 1.164 Answer. (a) Filing and service. Within 20 days...

  3. Are All Wrong FCI Answers Equivalent?

    Science.gov (United States)

    Dedic, Helena; Rosenfield, Steven; Lasry, Nathaniel

    2010-10-01

    The Force Concept Inventory (FCI) has been efficiently used to assess conceptual learning in mechanics. Each FCI question has one Newtonian answer and four wrong answers (distracters). Researchers and practitioners most frequently use measures of total score to assess learning. Yet, are all wrong answers equivalent? We conducted Latent Markov Chain Modeling (LMCM) analyses of all choices (right and wrong) on a subset of four FCI questions. LMCM assesses whether there are groups of students sharing similar patterns of responses. We infer that students sharing similar patterns also share similar reasoning. Our results show seven reasoning-groups. LMCM also computes probabilities of transition from one reasoning-group to another after instruction. Examining transitions between groups, we note a clear hierarchy. Groups at the top of the hierarchy are comprised of students that use Newtonian thinking more consistently but also choose certain wrong answers more frequently; suggesting that not all wrong answers are equivalent.

  4. Importance of Nanotechnologies in Supply of Sustainable Social Economic Development in Russia

    Directory of Open Access Journals (Sweden)

    V.V. Kovarda

    2013-12-01

    Full Text Available The importance of nanotechnologies for social economic development in Russia is analyzed in the article. The main tendencies at the world nanotechnology market are marked. The main macroeconomic figures tied with nanotechnologies are examined and analyzed.

  5. 76 FR 62469 - National Science and Technology Council, Committee on Technology; 2011 National Nanotechnology...

    Science.gov (United States)

    2011-10-07

    ... Nanotechnology Initiative Environmental, Health, and Safety Strategy Webinar ACTION: Notice of webinar. SUMMARY: The National Nanotechnology Coordination Office (NNCO), on behalf of the Nanoscale Science...-7128, National Nanotechnology Coordination Office. E-mail: webinar@nnco.nano.gov . Ted Wackler,...

  6. Nanomedicine and cancer therapies

    CERN Document Server

    Sebastian, Mathew; Elias, Eldho

    2012-01-01

    Introduction Nanotechnological-Based Systems for CancerIn vivo Spectroscopy for Detection and Treatment of GBM with NPt® ImplantationNanobiotechnology for Antibacterial Therapy and DiagnosisChitosan NanoparticlesSynthesis and Biomedical Application of Silver NanoparticlesRecent Advances in Cancer Therapy Using PhytochemicalsMitochondrial Dysfunction and Cancer: Modulation by Palladium-Lipoic Acid ComplexUnity of Mind and Body: The Concept of Life Purpose DominantThuja Occidentalis and Breast Cancer ChemopreventionAntioxidants and Com

  7. Nanotechnologies in Cuba: Popularization and Training

    Science.gov (United States)

    Rodríguez Castellanos, Carlos

    In Cuba, as in other countries, activities in the field of nanotechnology emerged from the converging development of research in materials physics and chemistry, microelectronics, supramolecular physics, microbiology and molecular biology. During the 1990s, theoretical and experimental work on semiconductor nanostructures gained in importance. Cuban physicists organized the Red CYTED (Network CYTED) to "study fabrication and characterization of semiconductor nanostructures for micro and optoelectronics" which functioned between 1998 and 2003 with the participation of eight Spanish-American countries. The network organized various courses and scientific meetings, edited a book and supported the scientific collaboration among the participant institutions.

  8. Nanocoating : A Novel Drift in Nanotechnology

    Directory of Open Access Journals (Sweden)

    Ravi Shankar Mishra

    2013-04-01

    Full Text Available – In this paper the elementary inkling of nanocoating is deliberated along with its conceivable present and future applications. By using nanotechnology, materials can effectively be made to be stronger, lighter, more durable. Recent attention focuses on nano composite materials and coatings. The nano materials and their corresponding nanocoating usage are mentioned briefly. Some nanocoating techniques such as Waterproof nanocoating, Electrostatic layer-by-layer nanocoating, Anti-graffiti and Sol-gel nanocoating, Anti-mist nanocoating, UV and IR protection nanocoating, Anti-glare nanocoating, are pronounced with their promising applications.

  9. RNA self-assembly and RNA nanotechnology.

    Science.gov (United States)

    Grabow, Wade W; Jaeger, Luc

    2014-06-17

    CONSPECTUS: Nanotechnology's central goal involves the direct control of matter at the molecular nanometer scale to build nanofactories, nanomachines, and other devices for potential applications including electronics, alternative fuels, and medicine. In this regard, the nascent use of nucleic acids as a material to coordinate the precise arrangements of specific molecules marked an important milestone in the relatively recent history of nanotechnology. While DNA served as the pioneer building material in nucleic acid nanotechnology, RNA continues to emerge as viable alternative material with its own distinct advantages for nanoconstruction. Several complementary assembly strategies have been used to build a diverse set of RNA nanostructures having unique structural attributes and the ability to self-assemble in a highly programmable and controlled manner. Of the different strategies, the architectonics approach uniquely endeavors to understand integrated structural RNA architectures through the arrangement of their characteristic structural building blocks. Viewed through this lens, it becomes apparent that nature routinely uses thermodynamically stable, recurrent modular motifs from natural RNA molecules to generate unique and more complex programmable structures. With the design principles found in natural structures, a number of synthetic RNAs have been constructed. The synthetic nanostructures constructed to date have provided, in addition to affording essential insights into RNA design, important platforms to characterize and validate the structural self-folding and assembly properties of RNA modules or building blocks. Furthermore, RNA nanoparticles have shown great promise for applications in nanomedicine and RNA-based therapeutics. Nevertheless, the synthetic RNA architectures achieved thus far consist largely of static, rigid particles that are still far from matching the structural and functional complexity of natural responsive structural elements such

  10. Soft matter nanotechnology from structure to function

    CERN Document Server

    Chen, Xiaodong

    2015-01-01

    Using the well-honed tools of nanotechnology, this book presents breakthrough results in soft matter research, benefitting from the synergies between the chemistry, physics, biology, materials science, and engineering communities. The team of international authors delves beyond mere structure-making and places the emphasis firmly on imparting functionality to soft nanomaterials with a focus on devices and applications. Alongside reviewing the current level of knowledge, they also put forward novel ideas to foster research and development in such expanding fields as nanobiotechnology and nanom

  11. Cement and Concrete Nanoscience and Nanotechnology

    Directory of Open Access Journals (Sweden)

    Taijiro Sato

    2010-02-01

    Full Text Available Concrete science is a multidisciplinary area of research where nanotechnology potentially offers the opportunity to enhance the understanding of concrete behavior, to engineer its properties and to lower production and ecological cost of construction materials. Recent work at the National Research Council Canada in the area of concrete materials research has shown the potential of improving concrete properties by modifying the structure of cement hydrates, addition of nanoparticles and nanotubes and controlling the delivery of admixtures. This article will focus on a review of these innovative achievements.

  12. Nanosciences and nanotechnology evolution or revolution?

    CERN Document Server

    Lahmani, Marcel; Dupas-Haeberlin, Claire; Hesto, Patrice

    2016-01-01

    This book provides information to the state of art of research in nanotechnology and nano medicine and risks of nano technology. It covers an interdisciplinary and very wide scope of the latest fundamental research status and industrial applications of nano technologies ranging from nano physics, nano chemistry to biotechnology and toxicology. It provides information to last legislation of nano usage and potential social impact too. The book contains also a reference list of major European research centers and associated universities offering licences and master of nano matter. For clarity and attractivity, the book has many illustrations and specific inserts to complete the understanding of the scientific texts.

  13. Micro and Nanotechnologies Enhanced Biomolecular Sensing

    Directory of Open Access Journals (Sweden)

    Tza-Huei Wang

    2013-07-01

    Full Text Available This editorial summarizes some of the recent advances of micro and nanotechnology-based tools and devices for biomolecular detection. These include the incorporation of nanomaterials into a sensor surface or directly interfacing with molecular probes to enhance target detection via more rapid and sensitive responses, and the use of self-assembled organic/inorganic nanocomposites that inhibit exceptional spectroscopic properties to enable facile homogenous assays with efficient binding kinetics. Discussions also include some insight into microfluidic principles behind the development of an integrated sample preparation and biosensor platform toward a miniaturized and fully functional system for point of care applications.

  14. Micro- and nanotechnologies for optical neural interfaces

    Directory of Open Access Journals (Sweden)

    Ferruccio ePisanello

    2016-03-01

    Full Text Available In last decade, the possibility to optically interface with the mammalian brain in vivo has allowed unprecedented investigation of functional connectivity of neural circuitry. Together with new genetic and molecular techniques to optically trigger and monitor neural activity, a new generation of optical neural interfaces is being developed, mainly thanks to the exploitation of both bottom-up and top-down nanofabrication approaches. This review discusses the role of nanotechnologies for optical neural interfaces, with particular emphasis on new devices and methodologies for optogenetic control of neural activity and unconventional methods for detection and triggering of action potentials using optically-active colloidal nanoparticles.

  15. Nanotechnologies, engineered nanomaterials and occupational health and safety - A review

    NARCIS (Netherlands)

    Savolainen, K.; Pylkkänen, L.; Norppa, H.; Falck, G.; Lindberg, H.; Tuomi, T.; Vippola, M.; Alenius, H.; Hämeri, K.; Koivisto, J.; Brouwer, D.; Mark, D.; Bard, D.; Berges, M.; Jankowska, E.; Posniak, M.; Farmer, P.; Singh, R.; Krombach, F.; Bihari, P.; Kasper, G.; Seipenbusch, M.

    2010-01-01

    The significance of engineered nanomaterials (ENM) and nanotechnologies grows rapidly. Nanotechnology applications may have a positive marked impact on many aspects of on human every day life, for example by providing means for the production of clean energy and pure drinking water. Hundreds of cons

  16. Consumer attitudes towards nanotechnologies applied to food production

    NARCIS (Netherlands)

    Frewer, L.J.; Gupta, N.; George, S.; Fischer, A.R.H.; Giles, E.L.; Coles, D.G.

    2014-01-01

    The literature on public perceptions of, and attitudes towards, nanotechnology used in the agrifood sector is reviewed. Research into consumer perceptions and attitudes has focused on general applications of nanotechnology, rather than within the agrifood sector. Perceptions of risk and benefit asso

  17. Nanotechnology in Mexico: Key Findings Based on OECD Criteria

    Science.gov (United States)

    Foladori, Guillermo; Arteaga Figueroa, Edgar; Záyago Lau, Edgar; Appelbaum, Richard; Robles-Belmont, Eduardo; Villa, Liliana; Parker, Rachel; Leos, Vanessa

    2015-01-01

    This analysis of Mexico's nanotechnology policies utilizes indicators developed by the Organization for Economic Co-operation and Development, which in 2008 conducted a pilot survey comparing the nanotechnology policies of 24 countries. In this paper, we apply the same questionnaire to the Mexican case, adding business information derived from the…

  18. A Study of Engineering Freshmen Regarding Nanotechnology Understanding

    Science.gov (United States)

    Lu, Kathy

    2009-01-01

    This study was conducted under the grand scheme of nanotechnology education and was focused on examining the nanotechnology readiness of first-year engineering students. The study found that most students learned the term "nano" from popular science magazines or as a measurement unit; less than 5% of the students learned "nano" through…

  19. Review of decision analytic tools for sustainable nanotechnology

    NARCIS (Netherlands)

    Subramanian, V.; Semenzin, E.; Hristozov, D.; Zondervan-van den Beuken, E.; Linkov, I.; Marcomini, A.

    2015-01-01

    Nanotechnology innovation is hampered by data gaps and knowledge limitations in evaluating the risks and impacts of nano-enabled products. ‘‘Sustainable nanotechnology’’ is a growing concept in the literature, which calls for a comprehensive evaluation of the risks and impacts of nanotechnology at a

  20. Nanotechnology Awareness, Opinions and Risk Perceptions among Middle School Students

    Science.gov (United States)

    Sahin, Nurettin; Ekli, Emel

    2013-01-01

    The present study investigates awareness, factual knowledge, opinions, and risk perceptions of students from Turkish middle schools with regard to nanotechnology in a very general sense. The study was carried out among 1,396 middle school 6th, 7th, and 8th grade students. The students' perceptions of and opinions about nanotechnology were…